locus-tag	class	description
C4K17_RS00010	COG0592	DNA-directed DNA polymerase activity
C4K17_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K17_RS00020	COG0187	DNA topoisomerase II activity
C4K17_RS00035	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS00040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4K17_RS00070	COG5002	protein histidine kinase activity
C4K17_RS00080	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4K17_RS00085	COG0751	glycine-tRNA ligase activity
C4K17_RS00090	COG0752	glycyl-tRNA synthetase alpha subunit
C4K17_RS00095	COG2818	Glycosylase
C4K17_RS00115	COG0569	domain protein
C4K17_RS00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4K17_RS00125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K17_RS00130	COG0242	peptide deformylase activity
C4K17_RS00140	COG0758	DNA mediated transformation
C4K17_RS00145	COG0009	L-threonylcarbamoyladenylate synthase
C4K17_RS00155	COG0408	coproporphyrinogen oxidase activity
C4K17_RS00160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K17_RS00175	COG3119	arylsulfatase activity
C4K17_RS00200	COG0159	tryptophan synthase activity
C4K17_RS00205	COG0133	tryptophan synthase activity
C4K17_RS00220	COG3360	Dodecin
C4K17_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS00235	COG1764	response to oxidative stress
C4K17_RS00265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4K17_RS00270	COG0339	signal peptide processing
C4K17_RS00275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4K17_RS00310	COG0659	secondary active sulfate transmembrane transporter activity
C4K17_RS00320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K17_RS00320	COG1565	acr, cog1565
C4K17_RS00325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K17_RS00330	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4K17_RS00360	COG0109	protoheme IX farnesyltransferase activity
C4K17_RS00375	COG2011	ABC-type metal ion transport system permease component
C4K17_RS00380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K17_RS00395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K17_RS00400	COG1121	(ABC) transporter
C4K17_RS00405	COG0735	belongs to the Fur family
C4K17_RS00410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4K17_RS00430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4K17_RS00435	COG3245	cytochrome
C4K17_RS00445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K17_RS00460	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K17_RS00465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K17_RS00470	COG5002	protein histidine kinase activity
C4K17_RS00475	COG2204	response regulator
C4K17_RS00485	COG5487	UPF0391 membrane protein
C4K17_RS00495	COG1301	dicarboxylic acid transport
C4K17_RS00500	COG0700	Nucleoside recognition
C4K17_RS00515	COG1127	ABC transporter
C4K17_RS00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K17_RS00530	COG0612	Peptidase, M16
C4K17_RS00535	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K17_RS00540	COG0861	Integral membrane protein TerC family
C4K17_RS00545	COG2851	Citrate transporter
C4K17_RS00585	COG0427	acetyl-CoA hydrolase
C4K17_RS00605	COG0583	DNA-binding transcription factor activity
C4K17_RS00610	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS00665	COG3712	iron ion homeostasis
C4K17_RS00670	COG1595	DNA-templated transcription, initiation
C4K17_RS00675	COG0840	transmembrane signaling receptor activity
C4K17_RS00685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K17_RS00705	COG1802	Transcriptional regulator
C4K17_RS00715	COG5001	Diguanylate cyclase
C4K17_RS00715	COG3300	MHYT domain
C4K17_RS00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS00750	COG2175	clavaminate synthase activity
C4K17_RS00760	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K17_RS00765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS00780	COG2814	Major facilitator Superfamily
C4K17_RS00855	COG0529	Catalyzes the synthesis of activated sulfate
C4K17_RS00870	COG0330	HflC and HflK could
C4K17_RS00905	COG1289	transmembrane transporter activity
C4K17_RS00915	COG1566	PFAM secretion protein HlyD family protein
C4K17_RS00930	COG5339	Protein conserved in bacteria
C4K17_RS00935	COG0457	Tetratricopeptide repeat
C4K17_RS00940	COG1649	PFAM Uncharacterised BCR, COG1649
C4K17_RS00940	COG0726	polysaccharide deacetylase
C4K17_RS00945	COG1215	transferase activity, transferring glycosyl groups
C4K17_RS00955	COG1881	PFAM PEBP family protein
C4K17_RS00960	COG2304	oxidoreductase activity
C4K17_RS00965	COG1595	DNA-templated transcription, initiation
C4K17_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS01040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K17_RS01045	COG0745	RESPONSE REGULATOR receiver
C4K17_RS01050	COG2199	diguanylate cyclase activity
C4K17_RS01070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4K17_RS01080	COG4208	sulfate ABC transporter
C4K17_RS01085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4K17_RS01120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS01125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS01150	COG4771	TonB-dependent receptor
C4K17_RS01245	COG2807	transmembrane transport
C4K17_RS01250	COG0590	tRNA wobble adenosine to inosine editing
C4K17_RS01260	COG0583	DNA-binding transcription factor activity
C4K17_RS01295	COG0765	amino acid transport
C4K17_RS01300	COG0765	amino acid transport
C4K17_RS01305	COG1126	abc transporter atp-binding protein
C4K17_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS01315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K17_RS01345	COG2011	ABC-type metal ion transport system permease component
C4K17_RS01350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K17_RS01380	COG1126	abc transporter atp-binding protein
C4K17_RS01385	COG0765	amino acid transport
C4K17_RS01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS01395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4K17_RS01400	COG1045	serine acetyltransferase
C4K17_RS01405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K17_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS01435	COG0583	DNA-binding transcription factor activity
C4K17_RS01450	COG1609	Transcriptional regulator
C4K17_RS01465	COG0667	Aldo Keto reductase
C4K17_RS01470	COG1487	ribonuclease activity
C4K17_RS01480	COG2175	clavaminate synthase activity
C4K17_RS01485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS01490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K17_RS01495	COG4521	taurine ABC transporter
C4K17_RS01500	COG2918	glutathione biosynthetic process
C4K17_RS01510	COG2183	response to ionizing radiation
C4K17_RS01520	COG2205	protein histidine kinase activity
C4K17_RS01525	COG0189	ligase activity
C4K17_RS01530	COG4067	protein conserved in archaea
C4K17_RS01530	COG0189	ligase activity
C4K17_RS01535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4K17_RS01545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4K17_RS01550	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4K17_RS01600	COG0514	ATP-dependent DNA helicase (RecQ)
C4K17_RS01605	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS01605	COG1024	Enoyl-CoA hydratase
C4K17_RS01610	COG0824	Thioesterase
C4K17_RS01620	COG0243	molybdopterin cofactor binding
C4K17_RS01625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4K17_RS01635	COG1652	LysM domain
C4K17_RS01640	COG1011	Hydrolase
C4K17_RS01645	COG0494	nUDIX hydrolase
C4K17_RS01680	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4K17_RS01690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K17_RS01700	COG2957	Belongs to the agmatine deiminase family
C4K17_RS01735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K17_RS01740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K17_RS01745	COG1845	cytochrome c oxidase, subunit III
C4K17_RS01750	COG1845	cytochrome c oxidase, subunit III
C4K17_RS01770	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4K17_RS01810	COG0529	Catalyzes the synthesis of activated sulfate
C4K17_RS01850	COG4215	(ABC) transporter
C4K17_RS01890	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4K17_RS01895	COG1194	a g-specific adenine glycosylase
C4K17_RS01910	COG2223	nitrite transmembrane transporter activity
C4K17_RS01915	COG0131	Imidazoleglycerol-phosphate dehydratase
C4K17_RS01920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K17_RS01930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4K17_RS01935	COG0107	imidazoleglycerol-phosphate synthase activity
C4K17_RS01945	COG2861	carbohydrate metabolic process
C4K17_RS01950	COG0793	Belongs to the peptidase S41A family
C4K17_RS01955	COG4942	peptidase
C4K17_RS01960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4K17_RS01975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4K17_RS01995	COG3852	Histidine kinase
C4K17_RS02035	COG0301	tRNA thio-modification
C4K17_RS02035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K17_RS02040	COG1217	gtp-binding protein TYPA
C4K17_RS02050	COG0058	SHG alpha-glucan phosphorylase activity
C4K17_RS02055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4K17_RS02090	COG0402	S-adenosylhomocysteine deaminase activity
C4K17_RS02110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K17_RS02120	COG4176	ABC-type proline glycine betaine transport system permease component
C4K17_RS02125	COG4175	Glycine betaine
C4K17_RS02125	COG0517	IMP dehydrogenase activity
C4K17_RS02130	COG2986	histidine ammonia-lyase
C4K17_RS02135	COG2986	histidine ammonia-lyase
C4K17_RS02140	COG1113	amino acid transport
C4K17_RS02145	COG1228	amidohydrolase
C4K17_RS02155	COG0596	Alpha beta hydrolase
C4K17_RS02160	COG1490	D-aminoacyl-tRNA deacylase activity
C4K17_RS02165	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K17_RS02170	COG2943	transferase activity, transferring hexosyl groups
C4K17_RS02175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS02180	COG0765	amino acid transport
C4K17_RS02190	COG0840	transmembrane signaling receptor activity
C4K17_RS02205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K17_RS02210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K17_RS02215	COG0140	phosphoribosyl-ATP diphosphatase activity
C4K17_RS02220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K17_RS02225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K17_RS02235	COG2226	methyltransferase
C4K17_RS02280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4K17_RS02285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4K17_RS02295	COG0018	arginyl-trna synthetase
C4K17_RS02300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4K17_RS02305	COG0254	rRNA binding
C4K17_RS02315	COG0281	malic enzyme
C4K17_RS02350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K17_RS02355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K17_RS02370	COG0069	glutamate synthase activity
C4K17_RS02370	COG0070	glutamate synthase
C4K17_RS02370	COG0067	glutamate synthase
C4K17_RS02375	COG0493	'glutamate synthase
C4K17_RS02380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4K17_RS02385	COG3111	PFAM Bacterial OB fold (BOF) protein
C4K17_RS02390	COG2814	Major facilitator Superfamily
C4K17_RS02395	COG0583	DNA-binding transcription factor activity
C4K17_RS02410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K17_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS02425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K17_RS02435	COG2226	methyltransferase
C4K17_RS02465	COG2986	histidine ammonia-lyase
C4K17_RS02490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K17_RS02510	COG1192	Involved in chromosome partitioning
C4K17_RS02515	COG3118	belongs to the thioredoxin family
C4K17_RS02520	COG4680	protein conserved in bacteria
C4K17_RS02530	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K17_RS02535	COG3264	Mechanosensitive ion channel
C4K17_RS02535	COG1196	nuclear chromosome segregation
C4K17_RS02540	COG3263	regulation of cellular component size
C4K17_RS02560	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS02565	COG0506	proline dehydrogenase activity
C4K17_RS02565	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K17_RS02565	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K17_RS02570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K17_RS02575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4K17_RS02580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K17_RS02600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4K17_RS02605	COG0859	PFAM glycosyl transferase family 9
C4K17_RS02610	COG0859	PFAM glycosyl transferase family 9
C4K17_RS02615	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS02640	COG2192	nodulation
C4K17_RS02645	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS02670	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS02685	COG1132	(ABC) transporter
C4K17_RS02705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4K17_RS02705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4K17_RS02715	COG0667	Aldo Keto reductase
C4K17_RS02735	COG1519	Transferase
C4K17_RS02740	COG1538	Outer membrane efflux protein
C4K17_RS02745	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4K17_RS02760	COG0494	nUDIX hydrolase
C4K17_RS02770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4K17_RS02775	COG3150	esterase
C4K17_RS02810	COG3830	Belongs to the UPF0237 family
C4K17_RS02810	COG0560	Phosphoserine phosphatase
C4K17_RS02815	COG0688	phosphatidylethanolamine metabolic process
C4K17_RS02840	COG1162	GTPase activity
C4K17_RS02845	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4K17_RS02850	COG2860	membrane
C4K17_RS02860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4K17_RS02860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4K17_RS02865	COG0802	atpase or kinase
C4K17_RS02870	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K17_RS02875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K17_RS02880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4K17_RS02885	COG1923	regulation of RNA biosynthetic process
C4K17_RS02890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4K17_RS02895	COG0330	HflC and HflK could
C4K17_RS02900	COG0330	HflC and HflK could
C4K17_RS02905	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4K17_RS02910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4K17_RS02915	COG0840	transmembrane signaling receptor activity
C4K17_RS02920	COG1178	ABC-type Fe3 transport system permease component
C4K17_RS02940	COG0557	exoribonuclease II activity
C4K17_RS02945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4K17_RS02950	COG0360	Binds together with S18 to 16S ribosomal RNA
C4K17_RS02955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4K17_RS02965	COG0359	binds to the 23S rRNA
C4K17_RS02970	COG0305	Participates in initiation and elongation during chromosome replication
C4K17_RS02975	COG1032	radical SAM domain protein
C4K17_RS02990	COG2308	Evidence 4 Homologs of previously reported genes of
C4K17_RS02990	COG2307	Protein conserved in bacteria
C4K17_RS03025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4K17_RS03030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4K17_RS03035	COG0583	DNA-binding transcription factor activity
C4K17_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS03045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS03055	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4K17_RS03080	COG4221	oxidoreductase activity
C4K17_RS03100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4K17_RS03105	COG0830	nickel cation binding
C4K17_RS03110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4K17_RS03125	COG2982	Protein involved in outer membrane biogenesis
C4K17_RS03130	COG0583	DNA-binding transcription factor activity
C4K17_RS03135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K17_RS03145	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4K17_RS03150	COG0697	spore germination
C4K17_RS03155	COG2207	Transcriptional regulator
C4K17_RS03170	COG0443	Heat shock 70 kDa protein
C4K17_RS03175	COG0484	heat shock protein binding
C4K17_RS03180	COG0789	Transcriptional regulator
C4K17_RS03190	COG0804	urea catabolic process
C4K17_RS03195	COG0832	Belongs to the urease beta subunit family
C4K17_RS03210	COG0831	urea catabolic process
C4K17_RS03215	COG0829	nickel cation binding
C4K17_RS03225	COG0411	ABC transporter
C4K17_RS03240	COG0683	leucine binding
C4K17_RS03245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K17_RS03255	COG1120	ATPase activity
C4K17_RS03295	COG3657	addiction module killer protein
C4K17_RS03305	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4K17_RS03315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K17_RS03340	COG2095	MarC family integral membrane protein
C4K17_RS03350	COG0151	Belongs to the GarS family
C4K17_RS03355	COG0138	bifunctional purine biosynthesis protein purh
C4K17_RS03365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K17_RS03375	COG2264	protein methyltransferase activity
C4K17_RS03390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K17_RS03420	COG0023	Translation Initiation Factor
C4K17_RS03425	COG1166	arginine decarboxylase activity
C4K17_RS03430	COG0534	Mate efflux family protein
C4K17_RS03435	COG2373	Large extracellular alpha-helical protein
C4K17_RS03445	COG4953	penicillin-binding protein 1C
C4K17_RS03455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K17_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS03565	COG0840	transmembrane signaling receptor activity
C4K17_RS03580	COG2217	Heavy metal translocating P-type atpase
C4K17_RS03610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4K17_RS03615	COG0583	DNA-binding transcription factor activity
C4K17_RS03620	COG0477	Major facilitator Superfamily
C4K17_RS03625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4K17_RS03640	COG0387	Pfam Sodium calcium exchanger
C4K17_RS03655	COG0789	Transcriptional regulator
C4K17_RS03675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K17_RS03695	COG0811	peptide transport
C4K17_RS03700	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4K17_RS03705	COG4603	Belongs to the binding-protein-dependent transport system permease family
C4K17_RS03710	COG3845	ABC transporter
C4K17_RS03720	COG1309	transcriptional regulator
C4K17_RS03725	COG2233	PERMEase
C4K17_RS03775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4K17_RS03780	COG1074	ATP-dependent DNA helicase activity
C4K17_RS03785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K17_RS03790	COG1126	abc transporter atp-binding protein
C4K17_RS03795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS03815	COG2199	diguanylate cyclase activity
C4K17_RS03865	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4K17_RS03870	COG3483	tryptophan 2,3-dioxygenase activity
C4K17_RS03875	COG1113	amino acid transport
C4K17_RS03880	COG0543	2 iron, 2 sulfur cluster binding
C4K17_RS03880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K17_RS03885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4K17_RS03890	COG4638	Rieske (2fe-2S)
C4K17_RS03900	COG1522	sequence-specific DNA binding
C4K17_RS03910	COG1113	amino acid transport
C4K17_RS03915	COG0583	DNA-binding transcription factor activity
C4K17_RS03930	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K17_RS03935	COG0583	DNA-binding transcription factor activity
C4K17_RS03950	COG2610	gluconate transmembrane transporter activity
C4K17_RS03960	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4K17_RS03985	COG0840	transmembrane signaling receptor activity
C4K17_RS04025	COG1309	transcriptional regulator
C4K17_RS04050	COG0583	DNA-binding transcription factor activity
C4K17_RS04085	COG0247	lactate metabolic process
C4K17_RS04090	COG1620	l-lactate permease
C4K17_RS04095	COG2186	Transcriptional regulator
C4K17_RS04100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4K17_RS04105	COG0733	neurotransmitter:sodium symporter activity
C4K17_RS04115	COG2914	Belongs to the UPF0125 (RnfH) family
C4K17_RS04120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4K17_RS04130	COG0497	DNA recombination
C4K17_RS04135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4K17_RS04140	COG0443	Heat shock 70 kDa protein
C4K17_RS04145	COG0484	heat shock protein binding
C4K17_RS04150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4K17_RS04155	COG0505	Belongs to the CarA family
C4K17_RS04160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4K17_RS04165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K17_RS04180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4K17_RS04190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4K17_RS04195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K17_RS04200	COG0149	triose-phosphate isomerase activity
C4K17_RS04205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4K17_RS04225	COG0195	Participates in both transcription termination and antitermination
C4K17_RS04230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4K17_RS04235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4K17_RS04240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4K17_RS04245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4K17_RS04250	COG1185	polyribonucleotide nucleotidyltransferase activity
C4K17_RS04280	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K17_RS04295	COG0084	hydrolase, TatD family'
C4K17_RS04300	COG1609	Transcriptional regulator
C4K17_RS04305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K17_RS04305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K17_RS04310	COG1105	Belongs to the carbohydrate kinase PfkB family
C4K17_RS04315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K17_RS04315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K17_RS04315	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4K17_RS04330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4K17_RS04335	COG4774	siderophore transport
C4K17_RS04340	COG3128	pkhd-type hydroxylase
C4K17_RS04350	COG0019	diaminopimelate decarboxylase activity
C4K17_RS04375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4K17_RS04385	COG4608	Belongs to the ABC transporter superfamily
C4K17_RS04390	COG0444	Belongs to the ABC transporter superfamily
C4K17_RS04395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K17_RS04400	COG0601	transmembrane transport
C4K17_RS04405	COG0747	negative chemotaxis
C4K17_RS04415	COG0747	negative chemotaxis
C4K17_RS04420	COG0747	negative chemotaxis
C4K17_RS04430	COG1396	sequence-specific DNA binding
C4K17_RS04430	COG1917	Cupin 2, conserved barrel domain protein
C4K17_RS04445	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4K17_RS04450	COG4178	(ABC) transporter
C4K17_RS04455	COG2186	Transcriptional regulator
C4K17_RS04470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K17_RS04480	COG2271	Major facilitator Superfamily
C4K17_RS04485	COG2721	sulfolactate sulfo-lyase activity
C4K17_RS04495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K17_RS04505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K17_RS04510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K17_RS04515	COG0154	amidase activity
C4K17_RS04520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K17_RS04525	COG1077	Cell shape determining protein MreB Mrl
C4K17_RS04530	COG1792	Involved in formation and maintenance of cell shape
C4K17_RS04540	COG0424	maF-like protein
C4K17_RS04545	COG1530	ribonuclease E activity
C4K17_RS04555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K17_RS04560	COG0312	modulator of DNA gyrase
C4K17_RS04565	COG3028	Belongs to the UPF0307 family
C4K17_RS04570	COG0312	modulator of DNA gyrase
C4K17_RS04605	COG1660	Displays ATPase and GTPase activities
C4K17_RS04620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4K17_RS04625	COG1137	ATPase activity
C4K17_RS04630	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4K17_RS04640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4K17_RS04650	COG1127	ABC transporter
C4K17_RS04655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K17_RS04660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4K17_RS04680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4K17_RS04685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4K17_RS04690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K17_RS04695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K17_RS04700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K17_RS04715	COG0175	sulfate reduction
C4K17_RS04725	COG0204	Acyl-transferase
C4K17_RS04730	COG0857	belongs to the CobB CobQ family
C4K17_RS04730	COG0280	phosphate acetyltransferase
C4K17_RS04745	COG0386	Belongs to the glutathione peroxidase family
C4K17_RS04760	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4K17_RS04770	COG0492	ferredoxin-NADP+ reductase activity
C4K17_RS04785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K17_RS04790	COG0302	gtp cyclohydrolase
C4K17_RS04805	COG0789	Transcriptional regulator
C4K17_RS04815	COG1366	Belongs to the anti-sigma-factor antagonist family
C4K17_RS04825	COG0583	DNA-binding transcription factor activity
C4K17_RS04830	COG1380	Effector of murein hydrolase LrgA
C4K17_RS04835	COG1346	cytolysis
C4K17_RS04845	COG0596	Alpha beta hydrolase
C4K17_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS04870	COG2909	trisaccharide binding
C4K17_RS04880	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4K17_RS04885	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K17_RS04895	COG2814	Major facilitator Superfamily
C4K17_RS04905	COG2226	methyltransferase
C4K17_RS04950	COG0814	amino acid
C4K17_RS04955	COG1760	l-serine dehydratase
C4K17_RS04960	COG0583	DNA-binding transcription factor activity
C4K17_RS04980	COG4772	TonB-dependent receptor
C4K17_RS04985	COG3712	iron ion homeostasis
C4K17_RS04990	COG1595	DNA-templated transcription, initiation
C4K17_RS05010	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K17_RS05020	COG0697	spore germination
C4K17_RS05030	COG0583	DNA-binding transcription factor activity
C4K17_RS05050	COG1566	PFAM secretion protein HlyD family protein
C4K17_RS05070	COG0300	oxidoreductase activity
C4K17_RS05110	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4K17_RS05110	COG0662	Cupin 2, conserved barrel domain protein
C4K17_RS05125	COG1696	Membrane protein involved in D-alanine export
C4K17_RS05140	COG3420	alginic acid biosynthetic process
C4K17_RS05150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4K17_RS05155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS05160	COG1215	transferase activity, transferring glycosyl groups
C4K17_RS05170	COG3022	response to hydroperoxide
C4K17_RS05180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4K17_RS05185	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K17_RS05190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K17_RS05200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS05220	COG0513	Belongs to the DEAD box helicase family
C4K17_RS05230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS05235	COG4597	amino acid ABC transporter
C4K17_RS05240	COG0765	amino acid transport
C4K17_RS05245	COG1126	abc transporter atp-binding protein
C4K17_RS05250	COG2944	sequence-specific DNA binding
C4K17_RS05260	COG2186	Transcriptional regulator
C4K17_RS05265	COG2807	transmembrane transport
C4K17_RS05275	COG2827	Endonuclease containing a URI domain
C4K17_RS05290	COG3081	Nucleoid-associated protein
C4K17_RS05300	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4K17_RS05305	COG0525	valine-tRNA ligase activity
C4K17_RS05320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4K17_RS05325	COG0795	lipopolysaccharide-transporting ATPase activity
C4K17_RS05330	COG0795	lipopolysaccharide-transporting ATPase activity
C4K17_RS05335	COG0481	GTPase activity
C4K17_RS05340	COG0681	Belongs to the peptidase S26 family
C4K17_RS05350	COG0571	ribonuclease III activity
C4K17_RS05355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4K17_RS05360	COG1381	Involved in DNA repair and RecF pathway recombination
C4K17_RS05365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4K17_RS05370	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K17_RS05375	COG0047	phosphoribosylformylglycinamidine synthase activity
C4K17_RS05375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4K17_RS05385	COG1263	PTS System
C4K17_RS05385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K17_RS05385	COG2190	(PTS) system
C4K17_RS05390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K17_RS05390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K17_RS05395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K17_RS05400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4K17_RS05405	COG2188	Transcriptional regulator
C4K17_RS05420	COG0494	nUDIX hydrolase
C4K17_RS05440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4K17_RS05445	COG0477	Major facilitator Superfamily
C4K17_RS05450	COG4536	flavin adenine dinucleotide binding
C4K17_RS05460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4K17_RS05465	COG0228	four-way junction DNA binding
C4K17_RS05470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4K17_RS05475	COG0336	Belongs to the RNA methyltransferase TrmD family
C4K17_RS05480	COG0335	large ribosomal subunit rRNA binding
C4K17_RS05485	COG1607	acyl-coa hydrolase
C4K17_RS05495	COG4974	Belongs to the 'phage' integrase family
C4K17_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS05515	COG2205	protein histidine kinase activity
C4K17_RS05525	COG2197	response regulator
C4K17_RS05545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K17_RS05560	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS05565	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K17_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS05600	COG1177	transmembrane transport
C4K17_RS05605	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K17_RS05610	COG3842	ATPase activity
C4K17_RS05615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K17_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS05625	COG0583	DNA-binding transcription factor activity
C4K17_RS05645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K17_RS05645	COG0457	Tetratricopeptide repeat
C4K17_RS05660	COG2201	protein-glutamate methylesterase activity
C4K17_RS05665	COG5001	Diguanylate cyclase
C4K17_RS05665	COG3706	GGDEF domain
C4K17_RS05665	COG4251	negative regulation of phosphorylation
C4K17_RS05665	COG2203	Gaf domain
C4K17_RS05675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4K17_RS05695	COG1073	alpha beta
C4K17_RS05720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4K17_RS05725	COG0563	adenylate kinase activity
C4K17_RS05730	COG1214	PFAM Peptidase M22, glycoprotease
C4K17_RS05740	COG1801	Protein of unknown function DUF72
C4K17_RS05755	COG0742	ribosomal rna small subunit methyltransferase
C4K17_RS05765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS05785	COG2937	Belongs to the GPAT DAPAT family
C4K17_RS05800	COG2226	methyltransferase
C4K17_RS05805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K17_RS05815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4K17_RS05825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K17_RS05830	COG2171	N-acyltransferase activity
C4K17_RS05835	COG1393	Belongs to the ArsC family
C4K17_RS05840	COG0025	NhaP-type Na H and K H
C4K17_RS05845	COG0436	Aminotransferase
C4K17_RS05850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4K17_RS05855	COG0024	Methionine aminopeptidase
C4K17_RS05860	COG0052	Belongs to the universal ribosomal protein uS2 family
C4K17_RS05865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4K17_RS05870	COG0528	UMP kinase activity
C4K17_RS05875	COG0233	cytoplasmic translational termination
C4K17_RS05880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4K17_RS05890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4K17_RS05910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K17_RS05915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K17_RS05920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K17_RS05925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K17_RS05930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4K17_RS05935	COG0587	DNA-directed DNA polymerase activity
C4K17_RS05940	COG0825	malonyl-CoA metabolic process
C4K17_RS05945	COG0037	tRNA processing
C4K17_RS05950	COG0504	CTP synthase activity
C4K17_RS05955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4K17_RS05960	COG0148	phosphopyruvate hydratase activity
C4K17_RS05970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4K17_RS05980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4K17_RS05985	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4K17_RS05990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4K17_RS05995	COG0585	pseudouridine synthase activity
C4K17_RS06000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K17_RS06005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4K17_RS06025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4K17_RS06050	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K17_RS06140	COG4386	tail sheath protein
C4K17_RS06175	COG4381	Mu-like prophage protein gp46
C4K17_RS06225	COG3179	chitinase
C4K17_RS06235	COG1546	Belongs to the CinA family
C4K17_RS06240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4K17_RS06245	COG2137	regulation of response to DNA damage stimulus
C4K17_RS06265	COG3148	PFAM DTW domain containing protein
C4K17_RS06280	COG0583	DNA-binding transcription factor activity
C4K17_RS06300	COG4807	Protein conserved in bacteria
C4K17_RS06305	COG1187	pseudouridine synthase activity
C4K17_RS06315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K17_RS06325	COG3158	transport of potassium into the cell
C4K17_RS06335	COG0392	lysyltransferase activity
C4K17_RS06335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4K17_RS06350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4K17_RS06360	COG0442	prolyl-tRNA aminoacylation
C4K17_RS06385	COG1278	Cold shock
C4K17_RS06390	COG0717	Belongs to the dCTP deaminase family
C4K17_RS06415	COG4215	(ABC) transporter
C4K17_RS06425	COG2366	antibiotic biosynthetic process
C4K17_RS06430	COG0625	glutathione transferase activity
C4K17_RS06440	COG0653	protein targeting
C4K17_RS06450	COG3012	SEC-C Motif Domain Protein
C4K17_RS06485	COG1199	ATP-dependent helicase activity
C4K17_RS06500	COG2885	chlorophyll binding
C4K17_RS06505	COG0259	pyridoxamine-phosphate oxidase activity
C4K17_RS06520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K17_RS06530	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4K17_RS06545	COG0583	DNA-binding transcription factor activity
C4K17_RS06560	COG3220	belongs to the UPF0276 family
C4K17_RS06605	COG2084	Dehydrogenase
C4K17_RS06615	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4K17_RS06620	COG2271	Major facilitator Superfamily
C4K17_RS06625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K17_RS06635	COG0306	phosphate transporter
C4K17_RS06650	COG1414	Transcriptional regulator
C4K17_RS06655	COG2814	Major facilitator Superfamily
C4K17_RS06660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K17_RS06665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4K17_RS06670	COG0183	Belongs to the thiolase family
C4K17_RS06675	COG3485	protocatechuate 3,4-dioxygenase
C4K17_RS06680	COG3485	protocatechuate 3,4-dioxygenase
C4K17_RS06685	COG0477	Major facilitator Superfamily
C4K17_RS06695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K17_RS06700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K17_RS06720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS06735	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS06740	COG2814	Major facilitator Superfamily
C4K17_RS06780	COG1473	amidohydrolase
C4K17_RS06790	COG0154	amidase activity
C4K17_RS06815	COG1704	LemA family
C4K17_RS06820	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4K17_RS06835	COG0697	spore germination
C4K17_RS06840	COG0693	protein deglycase activity
C4K17_RS06855	COG1629	transport
C4K17_RS06870	COG3422	double-strand break repair
C4K17_RS06875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K17_RS06880	COG0235	Class ii aldolase
C4K17_RS06885	COG1396	sequence-specific DNA binding
C4K17_RS06895	COG1454	alcohol dehydrogenase
C4K17_RS06900	COG1309	transcriptional regulator
C4K17_RS06910	COG3668	Plasmid stabilization system
C4K17_RS06985	COG3938	Belongs to the proline racemase family
C4K17_RS06990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K17_RS06995	COG0531	amino acid
C4K17_RS07005	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4K17_RS07025	COG0583	DNA-binding transcription factor activity
C4K17_RS07030	COG5001	Diguanylate cyclase
C4K17_RS07050	COG2267	carboxylic ester hydrolase activity
C4K17_RS07065	COG3706	GGDEF domain
C4K17_RS07080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4K17_RS07130	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4K17_RS07165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K17_RS07175	COG0425	Belongs to the sulfur carrier protein TusA family
C4K17_RS07185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4K17_RS07200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K17_RS07205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4K17_RS07210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K17_RS07215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4K17_RS07235	COG2197	response regulator
C4K17_RS07245	COG3121	Chaperone
C4K17_RS07250	COG3188	usher protein
C4K17_RS07255	COG3121	Chaperone
C4K17_RS07260	COG2831	hemolysin activation secretion protein
C4K17_RS07265	COG3210	domain, Protein
C4K17_RS07295	COG2807	transmembrane transport
C4K17_RS07300	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4K17_RS07310	COG0583	DNA-binding transcription factor activity
C4K17_RS07320	COG2194	sulfuric ester hydrolase activity
C4K17_RS07335	COG3100	YcgL domain-containing protein
C4K17_RS07340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K17_RS07350	COG2983	Belongs to the UPF0260 family
C4K17_RS07400	COG0121	glutamine amidotransferase
C4K17_RS07410	COG0583	DNA-binding transcription factor activity
C4K17_RS07415	COG2814	Major facilitator Superfamily
C4K17_RS07420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K17_RS07425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K17_RS07430	COG1984	allophanate hydrolase subunit 2
C4K17_RS07440	COG0542	response to heat
C4K17_RS07450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K17_RS07480	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4K17_RS07485	COG1643	Atp-dependent helicase
C4K17_RS07495	COG1595	DNA-templated transcription, initiation
C4K17_RS07510	COG0814	amino acid
C4K17_RS07530	COG4638	Rieske (2fe-2S)
C4K17_RS07545	COG0477	Major facilitator Superfamily
C4K17_RS07550	COG0583	DNA-binding transcription factor activity
C4K17_RS07560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4K17_RS07565	COG1132	(ABC) transporter
C4K17_RS07575	COG2267	carboxylic ester hydrolase activity
C4K17_RS07590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K17_RS07600	COG0668	transmembrane transport
C4K17_RS07605	COG0513	Belongs to the DEAD box helicase family
C4K17_RS07665	COG1953	Uracil, thiamine, allantoin
C4K17_RS07670	COG0697	spore germination
C4K17_RS07680	COG0583	DNA-binding transcription factor activity
C4K17_RS07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K17_RS07695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K17_RS07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS07750	COG5001	Diguanylate cyclase
C4K17_RS07750	COG3300	MHYT domain
C4K17_RS07760	COG2832	Protein of unknown function (DUF454)
C4K17_RS07785	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4K17_RS07800	COG2207	Transcriptional regulator
C4K17_RS07825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4K17_RS07845	COG0745	RESPONSE REGULATOR receiver
C4K17_RS07855	COG2350	Protein conserved in bacteria
C4K17_RS07860	COG2917	probably involved in intracellular septation
C4K17_RS07865	COG0613	PHP domain protein
C4K17_RS07870	COG0009	L-threonylcarbamoyladenylate synthase
C4K17_RS07880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4K17_RS07900	COG1113	amino acid transport
C4K17_RS07925	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4K17_RS07940	COG4786	Flagellar basal body rod
C4K17_RS07950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4K17_RS07955	COG1706	bacterial-type flagellum-dependent cell motility
C4K17_RS07965	COG1256	bacterial-type flagellum assembly
C4K17_RS07975	COG1216	Glycosyl transferase, family 2
C4K17_RS07975	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS07980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K17_RS07990	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4K17_RS08015	COG1216	Glycosyl transferase, family 2
C4K17_RS08015	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS08020	COG1086	Polysaccharide biosynthesis protein
C4K17_RS08025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K17_RS08030	COG1083	cytidylyl-transferase
C4K17_RS08040	COG2089	acid synthase
C4K17_RS08060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4K17_RS08070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4K17_RS08100	COG1677	Flagellar hook-basal body complex protein FliE
C4K17_RS08135	COG0745	RESPONSE REGULATOR receiver
C4K17_RS08215	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4K17_RS08220	COG0784	Response regulator, receiver
C4K17_RS08220	COG2198	Histidine kinase
C4K17_RS08220	COG0643	Histidine kinase
C4K17_RS08225	COG2201	protein-glutamate methylesterase activity
C4K17_RS08230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4K17_RS08240	COG1192	Involved in chromosome partitioning
C4K17_RS08250	COG0835	chemotaxis
C4K17_RS08260	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4K17_RS08270	COG4133	protoheme IX ABC transporter activity
C4K17_RS08290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4K17_RS08295	COG1138	Cytochrome C-type biogenesis protein
C4K17_RS08305	COG3088	subunit of a heme lyase
C4K17_RS08325	COG0583	DNA-binding transcription factor activity
C4K17_RS08330	COG2814	Major facilitator Superfamily
C4K17_RS08350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K17_RS08355	COG4413	Urea transporter
C4K17_RS08360	COG0469	pyruvate kinase activity
C4K17_RS08370	COG2084	Dehydrogenase
C4K17_RS08375	COG3622	Belongs to the hyi family
C4K17_RS08380	COG3960	tartronate-semialdehyde synthase activity
C4K17_RS08390	COG1309	transcriptional regulator
C4K17_RS08395	COG2354	Protein conserved in bacteria
C4K17_RS08400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K17_RS08415	COG1834	amidinotransferase
C4K17_RS08425	COG2192	nodulation
C4K17_RS08430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K17_RS08455	COG2853	Lipoprotein
C4K17_RS08475	COG2113	Glycine betaine
C4K17_RS08480	COG3162	membrane
C4K17_RS08485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K17_RS08495	COG2009	succinate dehydrogenase
C4K17_RS08500	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4K17_RS08505	COG1053	succinate dehydrogenase
C4K17_RS08525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K17_RS08530	COG0045	succinate-CoA ligase (ADP-forming) activity
C4K17_RS08570	COG0326	Molecular chaperone. Has ATPase activity
C4K17_RS08580	COG0626	cystathionine gamma-synthase activity
C4K17_RS08590	COG1741	Belongs to the pirin family
C4K17_RS08615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K17_RS08620	COG5002	protein histidine kinase activity
C4K17_RS08620	COG2205	protein histidine kinase activity
C4K17_RS08620	COG0784	Response regulator, receiver
C4K17_RS08630	COG4771	TonB-dependent receptor
C4K17_RS08635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4K17_RS08645	COG2062	phosphohistidine phosphatase, SixA
C4K17_RS08650	COG1022	Amp-dependent synthetase and ligase
C4K17_RS08670	COG0625	glutathione transferase activity
C4K17_RS08680	COG0628	permease
C4K17_RS08695	COG0284	orotidine-5'-phosphate decarboxylase activity
C4K17_RS08700	COG2130	NADP-dependent
C4K17_RS08705	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS08710	COG0840	transmembrane signaling receptor activity
C4K17_RS08740	COG2814	Major facilitator Superfamily
C4K17_RS08745	COG3210	domain, Protein
C4K17_RS08750	COG3121	Chaperone
C4K17_RS08760	COG2205	protein histidine kinase activity
C4K17_RS08760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS08780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K17_RS08795	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS08805	COG0625	glutathione transferase activity
C4K17_RS08810	COG1131	(ABC) transporter
C4K17_RS08815	COG0842	Transport permease protein
C4K17_RS08825	COG2333	competence protein COMEC
C4K17_RS08825	COG0658	competence protein
C4K17_RS08830	COG0811	peptide transport
C4K17_RS08835	COG0848	biopolymer transport protein
C4K17_RS08840	COG1663	tetraacyldisaccharide 4'-kinase activity
C4K17_RS08845	COG2835	tetraacyldisaccharide 4'-kinase activity
C4K17_RS08850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K17_RS08855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K17_RS08860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4K17_RS08870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K17_RS08875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4K17_RS08875	COG3608	succinylglutamate desuccinylase aspartoacylase
C4K17_RS08885	COG1530	ribonuclease E activity
C4K17_RS08895	COG0546	phosphoglycolate phosphatase activity
C4K17_RS08900	COG0616	signal peptide processing
C4K17_RS08900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K17_RS08905	COG0424	maF-like protein
C4K17_RS08915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4K17_RS08920	COG0416	fatty acid biosynthetic process
C4K17_RS08935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K17_RS08940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K17_RS08950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4K17_RS08955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4K17_RS08965	COG0084	hydrolase, TatD family'
C4K17_RS08980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K17_RS08995	COG2188	Transcriptional regulator
C4K17_RS09000	COG1397	ADP-ribosylglycohydrolase
C4K17_RS09010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K17_RS09040	COG1418	mRNA catabolic process
C4K17_RS09050	COG3734	2-keto-3-deoxy-galactonokinase
C4K17_RS09055	COG0800	Aldolase
C4K17_RS09060	COG4948	Mandelate Racemase Muconate Lactonizing
C4K17_RS09065	COG2271	Major facilitator Superfamily
C4K17_RS09070	COG1414	Transcriptional regulator
C4K17_RS09075	COG1064	alcohol dehydrogenase
C4K17_RS09080	COG2207	Transcriptional regulator
C4K17_RS09110	COG2885	chlorophyll binding
C4K17_RS09110	COG3047	cAMP biosynthetic process
C4K17_RS09150	COG0183	Belongs to the thiolase family
C4K17_RS09155	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS09155	COG1024	Enoyl-CoA hydratase
C4K17_RS09160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K17_RS09160	COG0519	Catalyzes the synthesis of GMP from XMP
C4K17_RS09165	COG0583	DNA-binding transcription factor activity
C4K17_RS09175	COG0598	Magnesium transport protein CorA
C4K17_RS09180	COG0204	Acyl-transferase
C4K17_RS09225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K17_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS09235	COG0583	DNA-binding transcription factor activity
C4K17_RS09245	COG1953	Uracil, thiamine, allantoin
C4K17_RS09255	COG0560	Phosphoserine phosphatase
C4K17_RS09275	COG4067	protein conserved in archaea
C4K17_RS09275	COG0189	ligase activity
C4K17_RS09280	COG1802	Transcriptional regulator
C4K17_RS09290	COG0372	Belongs to the citrate synthase family
C4K17_RS09305	COG2079	MmgE PrpD family protein
C4K17_RS09310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4K17_RS09325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K17_RS09340	COG0668	transmembrane transport
C4K17_RS09350	COG3047	cAMP biosynthetic process
C4K17_RS09350	COG2885	chlorophyll binding
C4K17_RS09355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K17_RS09360	COG0243	molybdopterin cofactor binding
C4K17_RS09365	COG2146	nitrite reductase [NAD(P)H] activity
C4K17_RS09370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K17_RS09375	COG2815	serine threonine protein kinase
C4K17_RS09375	COG0515	serine threonine protein kinase
C4K17_RS09380	COG2223	nitrite transmembrane transporter activity
C4K17_RS09385	COG3707	response regulator
C4K17_RS09390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS09395	COG0167	dihydroorotate dehydrogenase activity
C4K17_RS09400	COG3130	regulation of translation
C4K17_RS09405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K17_RS09405	COG0116	Belongs to the methyltransferase superfamily
C4K17_RS09415	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K17_RS09420	COG3171	Protein conserved in bacteria
C4K17_RS09425	COG3135	benzoate transporter
C4K17_RS09430	COG1802	Transcriptional regulator
C4K17_RS09435	COG0402	S-adenosylhomocysteine deaminase activity
C4K17_RS09460	COG1196	nuclear chromosome segregation
C4K17_RS09465	COG3115	cell septum assembly
C4K17_RS09470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K17_RS09525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4K17_RS09530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4K17_RS09535	COG2130	NADP-dependent
C4K17_RS09540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4K17_RS09545	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS09550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K17_RS09555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K17_RS09575	COG2217	Heavy metal translocating P-type atpase
C4K17_RS09585	COG0348	domain, Protein
C4K17_RS09600	COG2010	Cytochrome c
C4K17_RS09615	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K17_RS09620	COG2010	Cytochrome c
C4K17_RS09635	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K17_RS09645	COG0840	transmembrane signaling receptor activity
C4K17_RS09660	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4K17_RS09665	COG0425	Belongs to the sulfur carrier protein TusA family
C4K17_RS09675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K17_RS09685	COG1132	(ABC) transporter
C4K17_RS09690	COG0741	lytic transglycosylase activity
C4K17_RS09695	COG0488	(ABC) transporter
C4K17_RS09700	COG0589	response to stress
C4K17_RS09715	COG1024	Enoyl-CoA hydratase
C4K17_RS09715	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS09720	COG0183	Belongs to the thiolase family
C4K17_RS09765	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K17_RS09770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K17_RS09780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4K17_RS09795	COG1477	protein flavinylation
C4K17_RS09800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K17_RS09805	COG0584	glycerophosphoryl diester phosphodiesterase
C4K17_RS09815	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K17_RS09820	COG1136	(ABC) transporter
C4K17_RS09825	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K17_RS09845	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K17_RS09845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K17_RS09860	COG2853	Lipoprotein
C4K17_RS09875	COG2204	response regulator
C4K17_RS09885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4K17_RS09890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K17_RS09895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K17_RS09900	COG0583	DNA-binding transcription factor activity
C4K17_RS09910	COG2203	Gaf domain
C4K17_RS09910	COG3706	GGDEF domain
C4K17_RS09910	COG4251	negative regulation of phosphorylation
C4K17_RS09910	COG5001	Diguanylate cyclase
C4K17_RS09935	COG2233	PERMEase
C4K17_RS09965	COG0556	nucleotide-excision repair
C4K17_RS09980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K17_RS10010	COG0596	Alpha beta hydrolase
C4K17_RS10020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K17_RS10035	COG2214	Heat shock protein DnaJ domain protein
C4K17_RS10040	COG0443	Heat shock 70 kDa protein
C4K17_RS10055	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4K17_RS10060	COG0066	3-isopropylmalate dehydratase activity
C4K17_RS10065	COG0473	3-isopropylmalate dehydrogenase activity
C4K17_RS10095	COG0135	phosphoribosylanthranilate isomerase activity
C4K17_RS10100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4K17_RS10105	COG0285	dihydrofolate synthase activity
C4K17_RS10110	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K17_RS10115	COG1286	toxin biosynthetic process
C4K17_RS10150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS10180	COG3397	chitin binding
C4K17_RS10185	COG3469	chitinase activity
C4K17_RS10200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K17_RS10235	COG1129	ABC transporter
C4K17_RS10240	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K17_RS10245	COG1609	Transcriptional regulator
C4K17_RS10250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K17_RS10255	COG1869	D-ribose catabolic process
C4K17_RS10280	COG1278	Cold shock
C4K17_RS10290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K17_RS10295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4K17_RS10300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4K17_RS10305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4K17_RS10310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4K17_RS10315	COG0072	phenylalanine-tRNA ligase activity
C4K17_RS10320	COG0776	regulation of translation
C4K17_RS10385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K17_RS10420	COG1309	transcriptional regulator
C4K17_RS10425	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS10435	COG3284	Transcriptional regulator
C4K17_RS10440	COG3199	ATP-NAD kinase
C4K17_RS10445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K17_RS10450	COG0022	dehydrogenase e1 component
C4K17_RS10460	COG1063	alcohol dehydrogenase
C4K17_RS10475	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS10480	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS10485	COG4191	Histidine kinase
C4K17_RS10490	COG4566	intracellular signal transduction
C4K17_RS10505	COG1598	PFAM Uncharacterised protein family UPF0150
C4K17_RS10570	COG0450	alkyl hydroperoxide reductase
C4K17_RS10605	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K17_RS10610	COG3657	addiction module killer protein
C4K17_RS10615	COG5383	Protein conserved in bacteria
C4K17_RS10620	COG3706	GGDEF domain
C4K17_RS10645	COG0531	amino acid
C4K17_RS10655	COG0174	glutamine synthetase
C4K17_RS10660	COG1335	isochorismatase
C4K17_RS10670	COG0583	DNA-binding transcription factor activity
C4K17_RS10740	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4K17_RS10745	COG0247	lactate metabolic process
C4K17_RS10750	COG0277	FAD linked oxidase domain protein
C4K17_RS10755	COG0277	FAD linked oxidase domain protein
C4K17_RS10765	COG2186	Transcriptional regulator
C4K17_RS10795	COG1063	alcohol dehydrogenase
C4K17_RS10815	COG0709	Synthesizes selenophosphate from selenide and ATP
C4K17_RS10820	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4K17_RS10825	COG0701	Predicted permease
C4K17_RS10830	COG1414	Transcriptional regulator
C4K17_RS10835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS10840	COG0765	amino acid transport
C4K17_RS10845	COG1126	abc transporter atp-binding protein
C4K17_RS10850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS10860	COG0625	glutathione transferase activity
C4K17_RS10865	COG0384	phenazine biosynthesis protein PhzF
C4K17_RS10880	COG0248	Ppx GppA phosphatase
C4K17_RS10885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K17_RS10905	COG0019	diaminopimelate decarboxylase activity
C4K17_RS10920	COG0071	Belongs to the small heat shock protein (HSP20) family
C4K17_RS10925	COG0113	porphobilinogen synthase activity
C4K17_RS10960	COG4172	Belongs to the ABC transporter superfamily
C4K17_RS10965	COG4239	(ABC) transporter, permease
C4K17_RS10970	COG4174	ABC transporter (Permease)
C4K17_RS10975	COG4166	transmembrane transport
C4K17_RS11010	COG4650	regulator
C4K17_RS11020	COG1690	Belongs to the RtcB family
C4K17_RS11030	COG3541	Predicted nucleotidyltransferase
C4K17_RS11035	COG0430	RNA-3'-phosphate cyclase activity
C4K17_RS11060	COG0583	DNA-binding transcription factor activity
C4K17_RS11085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K17_RS11090	COG0583	DNA-binding transcription factor activity
C4K17_RS11095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K17_RS11105	COG3180	Ammonia monooxygenase
C4K17_RS11110	COG0583	DNA-binding transcription factor activity
C4K17_RS11115	COG0517	IMP dehydrogenase activity
C4K17_RS11135	COG1177	transmembrane transport
C4K17_RS11140	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K17_RS11145	COG3842	ATPase activity
C4K17_RS11150	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K17_RS11160	COG0174	glutamine synthetase
C4K17_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS11170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS11175	COG1396	sequence-specific DNA binding
C4K17_RS11175	COG1917	Cupin 2, conserved barrel domain protein
C4K17_RS11225	COG1595	DNA-templated transcription, initiation
C4K17_RS11230	COG3712	iron ion homeostasis
C4K17_RS11235	COG4772	TonB-dependent receptor
C4K17_RS11240	COG1944	ATP diphosphatase activity
C4K17_RS11310	COG2223	nitrite transmembrane transporter activity
C4K17_RS11330	COG0697	spore germination
C4K17_RS11335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K17_RS11345	COG0659	secondary active sulfate transmembrane transporter activity
C4K17_RS11355	COG1999	signal sequence binding
C4K17_RS11370	COG0583	DNA-binding transcription factor activity
C4K17_RS11375	COG3048	D-serine ammonia-lyase activity
C4K17_RS11380	COG2610	gluconate transmembrane transporter activity
C4K17_RS11385	COG0251	oxidation-reduction process
C4K17_RS11395	COG0688	phosphatidylethanolamine metabolic process
C4K17_RS11410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K17_RS11425	COG0477	Major facilitator Superfamily
C4K17_RS11430	COG0346	lactoylglutathione lyase activity
C4K17_RS11440	COG0826	peptidase U32
C4K17_RS11455	COG2205	protein histidine kinase activity
C4K17_RS11455	COG0784	Response regulator, receiver
C4K17_RS11470	COG2197	response regulator
C4K17_RS11480	COG1538	Outer membrane efflux protein
C4K17_RS11490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS11545	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K17_RS11555	COG1611	Belongs to the LOG family
C4K17_RS11570	COG2204	response regulator
C4K17_RS11575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4K17_RS11585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K17_RS11600	COG0494	nUDIX hydrolase
C4K17_RS11635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS11640	COG0174	glutamine synthetase
C4K17_RS11655	COG1335	isochorismatase
C4K17_RS11660	COG3224	Antibiotic biosynthesis monooxygenase
C4K17_RS11665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K17_RS11680	COG0417	DNA replication proofreading
C4K17_RS11690	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K17_RS11705	COG0477	Major facilitator Superfamily
C4K17_RS11725	COG4319	ketosteroid isomerase
C4K17_RS11730	COG4335	DNA alkylation repair
C4K17_RS11740	COG0583	DNA-binding transcription factor activity
C4K17_RS11745	COG2828	Protein conserved in bacteria
C4K17_RS11750	COG1301	dicarboxylic acid transport
C4K17_RS11755	COG2851	Citrate transporter
C4K17_RS11770	COG1704	LemA family
C4K17_RS11775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K17_RS11800	COG1230	cation diffusion facilitator family transporter
C4K17_RS11805	COG2267	carboxylic ester hydrolase activity
C4K17_RS11815	COG2124	cytochrome p450
C4K17_RS11820	COG0640	Transcriptional regulator
C4K17_RS11835	COG2308	Evidence 4 Homologs of previously reported genes of
C4K17_RS11845	COG1305	Transglutaminase-like
C4K17_RS11850	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K17_RS11855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4K17_RS11860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K17_RS11870	COG0022	dehydrogenase e1 component
C4K17_RS11875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K17_RS11880	COG1522	sequence-specific DNA binding
C4K17_RS11890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K17_RS11920	COG1309	transcriptional regulator
C4K17_RS11930	COG0493	'glutamate synthase
C4K17_RS11940	COG1953	Uracil, thiamine, allantoin
C4K17_RS11950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS11965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K17_RS11975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS11990	COG4804	nuclease activity
C4K17_RS12005	COG1595	DNA-templated transcription, initiation
C4K17_RS12015	COG1715	Restriction endonuclease
C4K17_RS12030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4K17_RS12070	COG2391	methyltransferase activity
C4K17_RS12125	COG3237	CsbD-like
C4K17_RS12140	COG0745	RESPONSE REGULATOR receiver
C4K17_RS12155	COG3383	formate dehydrogenase (NAD+) activity
C4K17_RS12160	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K17_RS12165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS12200	COG3718	enzyme involved in inositol metabolism
C4K17_RS12215	COG3962	Belongs to the TPP enzyme family
C4K17_RS12220	COG0673	inositol 2-dehydrogenase activity
C4K17_RS12225	COG1082	Xylose isomerase domain protein TIM barrel
C4K17_RS12230	COG0673	inositol 2-dehydrogenase activity
C4K17_RS12245	COG1129	ABC transporter
C4K17_RS12250	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4K17_RS12300	COG4774	siderophore transport
C4K17_RS12315	COG1320	monovalent cation:proton antiporter activity
C4K17_RS12320	COG2212	antiporter activity
C4K17_RS12330	COG0651	ATP synthesis coupled electron transport
C4K17_RS12335	COG1006	Multisubunit Na H antiporter MnhC subunit
C4K17_RS12340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4K17_RS12340	COG2111	Na H antiporter
C4K17_RS12405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K17_RS12410	COG0673	inositol 2-dehydrogenase activity
C4K17_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS12430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K17_RS12435	COG1335	isochorismatase
C4K17_RS12450	COG3383	formate dehydrogenase (NAD+) activity
C4K17_RS12460	COG0814	amino acid
C4K17_RS12490	COG0589	response to stress
C4K17_RS12500	COG0745	RESPONSE REGULATOR receiver
C4K17_RS12505	COG2205	protein histidine kinase activity
C4K17_RS12520	COG3791	Glutathione-dependent formaldehyde-activating
C4K17_RS12535	COG0583	DNA-binding transcription factor activity
C4K17_RS12540	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4K17_RS12545	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS12550	COG2079	MmgE PrpD family protein
C4K17_RS12605	COG0431	NADPH-dependent FMN reductase
C4K17_RS12665	COG2271	Major facilitator Superfamily
C4K17_RS12670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K17_RS12715	COG1073	alpha beta
C4K17_RS12775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K17_RS12790	COG0673	inositol 2-dehydrogenase activity
C4K17_RS12800	COG1609	Transcriptional regulator
C4K17_RS12860	COG0596	Alpha beta hydrolase
C4K17_RS12865	COG2384	SAM-dependent methyltransferase
C4K17_RS12870	COG0789	Transcriptional regulator
C4K17_RS12875	COG1090	epimerase
C4K17_RS12940	COG2080	2 iron, 2 sulfur cluster binding
C4K17_RS12945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4K17_RS12950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K17_RS12955	COG1280	lysine exporter protein (LysE YggA)
C4K17_RS12960	COG2205	protein histidine kinase activity
C4K17_RS12975	COG0540	Belongs to the ATCase OTCase family
C4K17_RS13005	COG1566	PFAM secretion protein HlyD family protein
C4K17_RS13015	COG2828	Protein conserved in bacteria
C4K17_RS13020	COG2207	Transcriptional regulator
C4K17_RS13040	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K17_RS13045	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4K17_RS13090	COG2084	Dehydrogenase
C4K17_RS13095	COG3395	kinase activity
C4K17_RS13100	COG0235	Class ii aldolase
C4K17_RS13105	COG2610	gluconate transmembrane transporter activity
C4K17_RS13110	COG3622	Belongs to the hyi family
C4K17_RS13120	COG1349	DNA-binding transcription factor activity
C4K17_RS13175	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS13180	COG4221	oxidoreductase activity
C4K17_RS13185	COG0596	Alpha beta hydrolase
C4K17_RS13185	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4K17_RS13190	COG0604	alcohol dehydrogenase
C4K17_RS13190	COG3321	synthase
C4K17_RS13195	COG2202	Pas domain
C4K17_RS13195	COG2200	EAL domain
C4K17_RS13195	COG2199	diguanylate cyclase activity
C4K17_RS13200	COG0833	amino acid
C4K17_RS13205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS13210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4K17_RS13225	COG0494	nUDIX hydrolase
C4K17_RS13235	COG3220	belongs to the UPF0276 family
C4K17_RS13245	COG2259	Doxx family
C4K17_RS13255	COG2205	protein histidine kinase activity
C4K17_RS13310	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K17_RS13330	COG0754	glutathionylspermidine amidase activity
C4K17_RS13340	COG3766	membrane
C4K17_RS13360	COG1842	Phage shock protein A
C4K17_RS13395	COG0583	DNA-binding transcription factor activity
C4K17_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS13425	COG4172	Belongs to the ABC transporter superfamily
C4K17_RS13430	COG4239	(ABC) transporter, permease
C4K17_RS13435	COG4174	ABC transporter (Permease)
C4K17_RS13440	COG4166	transmembrane transport
C4K17_RS13445	COG4166	transmembrane transport
C4K17_RS13450	COG0741	lytic transglycosylase activity
C4K17_RS13450	COG1388	LysM domain
C4K17_RS13455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K17_RS13465	COG0328	RNA-DNA hybrid ribonuclease activity
C4K17_RS13480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K17_RS13505	COG0431	NADPH-dependent FMN reductase
C4K17_RS13510	COG0640	Transcriptional regulator
C4K17_RS13525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4K17_RS13530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K17_RS13540	COG3139	Protein of unknown function (DUF1315)
C4K17_RS13550	COG0308	aminopeptidase N
C4K17_RS13555	COG0659	secondary active sulfate transmembrane transporter activity
C4K17_RS13575	COG2706	6-phosphogluconolactonase activity
C4K17_RS13605	COG0420	3'-5' exonuclease activity
C4K17_RS13620	COG0583	DNA-binding transcription factor activity
C4K17_RS13665	COG0714	Associated with various cellular activities
C4K17_RS13670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K17_RS13675	COG0477	Major facilitator Superfamily
C4K17_RS13680	COG0579	oxidoreductase
C4K17_RS13685	COG2186	Transcriptional regulator
C4K17_RS13715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K17_RS13870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K17_RS13890	COG1794	racemase activity, acting on amino acids and derivatives
C4K17_RS13925	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K17_RS13930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K17_RS13965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K17_RS13970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K17_RS13975	COG1538	Outer membrane efflux protein
C4K17_RS13985	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS13990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K17_RS13995	COG0348	domain, Protein
C4K17_RS14005	COG1285	pathogenesis
C4K17_RS14025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K17_RS14035	COG3568	Endonuclease Exonuclease Phosphatase
C4K17_RS14060	COG1640	4-alpha-glucanotransferase
C4K17_RS14065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K17_RS14070	COG0297	glycogen (starch) synthase activity
C4K17_RS14075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K17_RS14085	COG1238	metal cluster binding
C4K17_RS14125	COG0667	Aldo Keto reductase
C4K17_RS14130	COG0583	DNA-binding transcription factor activity
C4K17_RS14145	COG2366	antibiotic biosynthetic process
C4K17_RS14210	COG0583	DNA-binding transcription factor activity
C4K17_RS14220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K17_RS14220	COG1017	nitric oxide dioxygenase activity
C4K17_RS14225	COG0583	DNA-binding transcription factor activity
C4K17_RS14230	COG2066	Belongs to the glutaminase family
C4K17_RS14240	COG2233	PERMEase
C4K17_RS14250	COG0010	Belongs to the arginase family
C4K17_RS14265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K17_RS14300	COG2194	sulfuric ester hydrolase activity
C4K17_RS14305	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4K17_RS14310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4K17_RS14315	COG0561	phosphatase activity
C4K17_RS14320	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K17_RS14325	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS14325	COG2030	dehydratase
C4K17_RS14340	COG3162	membrane
C4K17_RS14345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K17_RS14350	COG2151	metal-sulfur cluster biosynthetic enzyme
C4K17_RS14355	COG3396	Phenylacetate-CoA oxygenase
C4K17_RS14360	COG3460	Phenylacetate-CoA oxygenase
C4K17_RS14365	COG3396	Phenylacetate-CoA oxygenase
C4K17_RS14375	COG0183	Belongs to the thiolase family
C4K17_RS14380	COG2050	protein possibly involved in aromatic compounds catabolism
C4K17_RS14385	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS14390	COG1024	Enoyl-CoA hydratase
C4K17_RS14395	COG1024	Enoyl-CoA hydratase
C4K17_RS14405	COG3327	negative regulation of DNA-templated transcription, initiation
C4K17_RS14425	COG2204	response regulator
C4K17_RS14470	COG0840	transmembrane signaling receptor activity
C4K17_RS14475	COG1968	undecaprenyl-diphosphatase activity
C4K17_RS14495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K17_RS14510	COG0488	(ABC) transporter
C4K17_RS14530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4K17_RS14540	COG2133	pyrroloquinoline quinone binding
C4K17_RS14550	COG0189	ligase activity
C4K17_RS14555	COG0598	Magnesium transport protein CorA
C4K17_RS14560	COG0024	Methionine aminopeptidase
C4K17_RS14575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K17_RS14580	COG4574	serine-type endopeptidase inhibitor activity
C4K17_RS14650	COG0726	polysaccharide deacetylase
C4K17_RS14660	COG0463	Glycosyl transferase, family 2
C4K17_RS14720	COG1070	Carbohydrate kinase
C4K17_RS14740	COG1175	transmembrane transport
C4K17_RS14750	COG4774	siderophore transport
C4K17_RS14755	COG2207	Transcriptional regulator
C4K17_RS14760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K17_RS14770	COG0183	Belongs to the thiolase family
C4K17_RS14775	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS14780	COG1024	Enoyl-CoA hydratase
C4K17_RS14785	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS14790	COG1024	Enoyl-CoA hydratase
C4K17_RS14805	COG2814	Major facilitator Superfamily
C4K17_RS14835	COG0765	amino acid transport
C4K17_RS14840	COG0165	Argininosuccinate lyase
C4K17_RS14865	COG2076	Multidrug Resistance protein
C4K17_RS14870	COG2076	Multidrug Resistance protein
C4K17_RS14875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K17_RS14880	COG0726	polysaccharide deacetylase
C4K17_RS14885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K17_RS14885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K17_RS14890	COG0463	Glycosyl transferase, family 2
C4K17_RS14895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K17_RS14900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K17_RS14905	COG0642	Histidine kinase
C4K17_RS14920	COG1131	(ABC) transporter
C4K17_RS14950	COG0747	negative chemotaxis
C4K17_RS14970	COG0667	Aldo Keto reductase
C4K17_RS14975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K17_RS14980	COG4172	Belongs to the ABC transporter superfamily
C4K17_RS14995	COG0477	Major facilitator Superfamily
C4K17_RS15015	COG0405	Gamma-glutamyltransferase
C4K17_RS15045	COG0589	response to stress
C4K17_RS15095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS15100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K17_RS15115	COG1024	Enoyl-CoA hydratase
C4K17_RS15115	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS15150	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS15160	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS15165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K17_RS15165	COG4221	oxidoreductase activity
C4K17_RS15165	COG3321	synthase
C4K17_RS15165	COG0300	oxidoreductase activity
C4K17_RS15170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS15175	COG1231	oxidoreductase activity
C4K17_RS15190	COG2863	cytochrome
C4K17_RS15210	COG0251	oxidation-reduction process
C4K17_RS15220	COG0745	RESPONSE REGULATOR receiver
C4K17_RS15235	COG0702	epimerase
C4K17_RS15250	COG1335	isochorismatase
C4K17_RS15300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K17_RS15305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K17_RS15340	COG4608	Belongs to the ABC transporter superfamily
C4K17_RS15345	COG0444	Belongs to the ABC transporter superfamily
C4K17_RS15350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K17_RS15355	COG0601	transmembrane transport
C4K17_RS15360	COG0747	negative chemotaxis
C4K17_RS15365	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4K17_RS15375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K17_RS15380	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4K17_RS15385	COG3540	Alkaline phosphatase
C4K17_RS15390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4K17_RS15410	COG0811	peptide transport
C4K17_RS15420	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K17_RS15435	COG2084	Dehydrogenase
C4K17_RS15465	COG1116	anion transmembrane transporter activity
C4K17_RS15470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS15475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS15480	COG0235	Class ii aldolase
C4K17_RS15485	COG0583	DNA-binding transcription factor activity
C4K17_RS15505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS15515	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS15520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K17_RS15560	COG2828	Protein conserved in bacteria
C4K17_RS15565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4K17_RS15570	COG2851	Citrate transporter
C4K17_RS15595	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C4K17_RS15620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K17_RS15625	COG0475	glutathione-regulated potassium exporter activity
C4K17_RS15655	COG1196	nuclear chromosome segregation
C4K17_RS15655	COG3264	Mechanosensitive ion channel
C4K17_RS15660	COG3204	pilus organization
C4K17_RS15665	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K17_RS15675	COG0463	Glycosyl transferase, family 2
C4K17_RS15685	COG3706	GGDEF domain
C4K17_RS15690	COG0583	DNA-binding transcription factor activity
C4K17_RS15695	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS15755	COG0277	FAD linked oxidase domain protein
C4K17_RS15755	COG0247	lactate metabolic process
C4K17_RS15760	COG0583	DNA-binding transcription factor activity
C4K17_RS15775	COG4104	PAAR repeat-containing protein
C4K17_RS15805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K17_RS15805	COG2146	nitrite reductase [NAD(P)H] activity
C4K17_RS15810	COG2146	nitrite reductase [NAD(P)H] activity
C4K17_RS15810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K17_RS15815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K17_RS15825	COG1120	ATPase activity
C4K17_RS15830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K17_RS15835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K17_RS15840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K17_RS15845	COG4264	IucA IucC family
C4K17_RS15855	COG4264	IucA IucC family
C4K17_RS15860	COG2814	Major facilitator Superfamily
C4K17_RS15865	COG0019	diaminopimelate decarboxylase activity
C4K17_RS15870	COG4264	IucA IucC family
C4K17_RS15875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K17_RS15880	COG4774	siderophore transport
C4K17_RS15885	COG3712	iron ion homeostasis
C4K17_RS15890	COG1595	DNA-templated transcription, initiation
C4K17_RS15910	COG0174	glutamine synthetase
C4K17_RS15920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS15930	COG2200	EAL domain
C4K17_RS15955	COG2205	protein histidine kinase activity
C4K17_RS15955	COG0784	Response regulator, receiver
C4K17_RS15985	COG1522	sequence-specific DNA binding
C4K17_RS15995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K17_RS16005	COG0473	3-isopropylmalate dehydrogenase activity
C4K17_RS16040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K17_RS16045	COG0601	transmembrane transport
C4K17_RS16050	COG0747	negative chemotaxis
C4K17_RS16055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS16095	COG0589	response to stress
C4K17_RS16100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS16105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS16110	COG1116	anion transmembrane transporter activity
C4K17_RS16125	COG1917	Cupin 2, conserved barrel domain protein
C4K17_RS16125	COG4977	sequence-specific DNA binding
C4K17_RS16180	COG0656	L-ascorbic acid biosynthetic process
C4K17_RS16185	COG0784	Response regulator, receiver
C4K17_RS16185	COG2205	protein histidine kinase activity
C4K17_RS16190	COG5001	Diguanylate cyclase
C4K17_RS16190	COG3300	MHYT domain
C4K17_RS16200	COG2197	response regulator
C4K17_RS16220	COG0513	Belongs to the DEAD box helicase family
C4K17_RS16240	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K17_RS16245	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K17_RS16290	COG1113	amino acid transport
C4K17_RS16310	COG0531	amino acid
C4K17_RS16325	COG2909	trisaccharide binding
C4K17_RS16335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K17_RS16340	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS16360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS16375	COG0210	DNA helicase
C4K17_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS16390	COG3321	synthase
C4K17_RS16390	COG0604	alcohol dehydrogenase
C4K17_RS16445	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS16460	COG3469	chitinase activity
C4K17_RS16465	COG3397	chitin binding
C4K17_RS16470	COG0583	DNA-binding transcription factor activity
C4K17_RS16490	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS16510	COG2072	flavoprotein involved in K transport
C4K17_RS16515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS16520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS16525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS16540	COG1566	PFAM secretion protein HlyD family protein
C4K17_RS16565	COG2205	protein histidine kinase activity
C4K17_RS16565	COG2198	Histidine kinase
C4K17_RS16565	COG0784	Response regulator, receiver
C4K17_RS16575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K17_RS16580	COG0784	Response regulator, receiver
C4K17_RS16580	COG2205	protein histidine kinase activity
C4K17_RS16580	COG2198	Histidine kinase
C4K17_RS16600	COG0672	)-iron permease
C4K17_RS16605	COG2822	iron ion transport
C4K17_RS16625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K17_RS16640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS16655	COG2816	NAD+ diphosphatase activity
C4K17_RS16660	COG1024	Enoyl-CoA hydratase
C4K17_RS16675	COG1335	isochorismatase
C4K17_RS16680	COG2205	protein histidine kinase activity
C4K17_RS16685	COG0745	RESPONSE REGULATOR receiver
C4K17_RS16690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS16730	COG1609	Transcriptional regulator
C4K17_RS16740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K17_RS16805	COG2814	Major facilitator Superfamily
C4K17_RS16810	COG1063	alcohol dehydrogenase
C4K17_RS16850	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS16855	COG3384	dioxygenase
C4K17_RS16865	COG2271	Major facilitator Superfamily
C4K17_RS16870	COG3971	2-oxopent-4-enoate hydratase activity
C4K17_RS16880	COG1929	Belongs to the glycerate kinase type-1 family
C4K17_RS16885	COG3835	regulator
C4K17_RS16890	COG2271	Major facilitator Superfamily
C4K17_RS16895	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS16905	COG0583	DNA-binding transcription factor activity
C4K17_RS16910	COG0667	Aldo Keto reductase
C4K17_RS16920	COG1846	Transcriptional regulator
C4K17_RS16930	COG0697	spore germination
C4K17_RS16935	COG0583	DNA-binding transcription factor activity
C4K17_RS16940	COG2200	EAL domain
C4K17_RS17005	COG3258	Cytochrome c
C4K17_RS17010	COG2863	cytochrome
C4K17_RS17030	COG3145	DNA-N1-methyladenine dioxygenase activity
C4K17_RS17035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K17_RS17035	COG2169	Transcriptional regulator
C4K17_RS17045	COG0604	alcohol dehydrogenase
C4K17_RS17070	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4K17_RS17080	COG0488	(ABC) transporter
C4K17_RS17090	COG0393	Putative heavy-metal-binding
C4K17_RS17200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K17_RS17205	COG0583	DNA-binding transcription factor activity
C4K17_RS17215	COG0475	glutathione-regulated potassium exporter activity
C4K17_RS17215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K17_RS17260	COG3121	Chaperone
C4K17_RS17265	COG3539	Fimbrial protein
C4K17_RS17270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS17270	COG2205	protein histidine kinase activity
C4K17_RS17275	COG2197	response regulator
C4K17_RS17280	COG2203	Gaf domain
C4K17_RS17280	COG3706	GGDEF domain
C4K17_RS17280	COG4251	negative regulation of phosphorylation
C4K17_RS17280	COG5001	Diguanylate cyclase
C4K17_RS17290	COG2197	response regulator
C4K17_RS17315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K17_RS17335	COG4638	Rieske (2fe-2S)
C4K17_RS17355	COG0154	amidase activity
C4K17_RS17370	COG0411	ABC transporter
C4K17_RS17385	COG0235	Class ii aldolase
C4K17_RS17400	COG1388	LysM domain
C4K17_RS17400	COG1470	cell adhesion involved in biofilm formation
C4K17_RS17410	COG3293	Transposase
C4K17_RS17425	COG3039	Transposase
C4K17_RS17435	COG2205	protein histidine kinase activity
C4K17_RS17435	COG0784	Response regulator, receiver
C4K17_RS17440	COG3706	GGDEF domain
C4K17_RS17440	COG5001	Diguanylate cyclase
C4K17_RS17440	COG2203	Gaf domain
C4K17_RS17440	COG4251	negative regulation of phosphorylation
C4K17_RS17450	COG2205	protein histidine kinase activity
C4K17_RS17450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS17455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS17455	COG2205	protein histidine kinase activity
C4K17_RS17465	COG2197	response regulator
C4K17_RS17505	COG2986	histidine ammonia-lyase
C4K17_RS17510	COG1304	FMN binding
C4K17_RS17515	COG0277	FAD linked oxidase domain protein
C4K17_RS17520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS17525	COG0765	amino acid transport
C4K17_RS17530	COG0765	amino acid transport
C4K17_RS17540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K17_RS17545	COG2188	Transcriptional regulator
C4K17_RS17555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS17565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K17_RS17570	COG1063	alcohol dehydrogenase
C4K17_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS17620	COG2894	cell division
C4K17_RS17660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4K17_RS17675	COG2003	Belongs to the UPF0758 family
C4K17_RS17720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS17725	COG1126	abc transporter atp-binding protein
C4K17_RS17730	COG0765	amino acid transport
C4K17_RS17740	COG4221	oxidoreductase activity
C4K17_RS17745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K17_RS17755	COG1984	allophanate hydrolase subunit 2
C4K17_RS17760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K17_RS17770	COG0511	ligase activity, forming carbon-carbon bonds
C4K17_RS17780	COG0436	Aminotransferase
C4K17_RS17920	COG0667	Aldo Keto reductase
C4K17_RS17975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K17_RS18000	COG0582	viral genome integration into host DNA
C4K17_RS18010	COG2135	peptidase activity
C4K17_RS18250	COG3617	BRO family, N-terminal domain
C4K17_RS18395	COG0270	DNA (cytosine-5-)-methyltransferase activity
C4K17_RS18470	COG3179	chitinase
C4K17_RS18490	COG0583	DNA-binding transcription factor activity
C4K17_RS18495	COG0583	DNA-binding transcription factor activity
C4K17_RS18500	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K17_RS18505	COG0300	oxidoreductase activity
C4K17_RS18515	COG0583	DNA-binding transcription factor activity
C4K17_RS18520	COG1309	transcriptional regulator
C4K17_RS18545	COG0475	glutathione-regulated potassium exporter activity
C4K17_RS18550	COG1024	Enoyl-CoA hydratase
C4K17_RS18555	COG0515	serine threonine protein kinase
C4K17_RS18560	COG1073	alpha beta
C4K17_RS18575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS18580	COG0789	Transcriptional regulator
C4K17_RS18595	COG3604	Transcriptional regulator
C4K17_RS18600	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C4K17_RS18625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K17_RS18630	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K17_RS18650	COG3712	iron ion homeostasis
C4K17_RS18655	COG1595	DNA-templated transcription, initiation
C4K17_RS18680	COG0601	transmembrane transport
C4K17_RS18685	COG0747	negative chemotaxis
C4K17_RS18695	COG3191	aminopeptidase activity
C4K17_RS18700	COG4206	TonB-dependent receptor
C4K17_RS18705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS18710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K17_RS18715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS18720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS18725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS18775	COG0583	DNA-binding transcription factor activity
C4K17_RS18780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS18790	COG0861	Integral membrane protein TerC family
C4K17_RS18810	COG2814	Major facilitator Superfamily
C4K17_RS18865	COG2207	Transcriptional regulator
C4K17_RS18870	COG1064	alcohol dehydrogenase
C4K17_RS18890	COG1733	regulation of RNA biosynthetic process
C4K17_RS18920	COG1022	Amp-dependent synthetase and ligase
C4K17_RS18925	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS18930	COG1024	Enoyl-CoA hydratase
C4K17_RS18945	COG2814	Major facilitator Superfamily
C4K17_RS18960	COG1136	(ABC) transporter
C4K17_RS18960	COG0577	efflux transmembrane transporter activity
C4K17_RS18965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS19025	COG3121	Chaperone
C4K17_RS19050	COG2197	response regulator
C4K17_RS19055	COG1538	Outer membrane efflux protein
C4K17_RS19085	COG3622	Belongs to the hyi family
C4K17_RS19105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K17_RS19115	COG1136	(ABC) transporter
C4K17_RS19120	COG2815	serine threonine protein kinase
C4K17_RS19120	COG0515	serine threonine protein kinase
C4K17_RS19260	COG4191	Histidine kinase
C4K17_RS19265	COG4566	intracellular signal transduction
C4K17_RS19270	COG4566	intracellular signal transduction
C4K17_RS19305	COG0583	DNA-binding transcription factor activity
C4K17_RS19315	COG1335	isochorismatase
C4K17_RS19320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K17_RS19340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4K17_RS19375	COG1741	Belongs to the pirin family
C4K17_RS19400	COG1335	isochorismatase
C4K17_RS19420	COG2814	Major facilitator Superfamily
C4K17_RS19425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K17_RS19425	COG2010	Cytochrome c
C4K17_RS19430	COG2080	2 iron, 2 sulfur cluster binding
C4K17_RS19435	COG2010	Cytochrome c
C4K17_RS19435	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K17_RS19440	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS19445	COG2205	protein histidine kinase activity
C4K17_RS19445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS19450	COG1301	dicarboxylic acid transport
C4K17_RS19460	COG2207	Transcriptional regulator
C4K17_RS19465	COG0300	oxidoreductase activity
C4K17_RS19485	COG0583	DNA-binding transcription factor activity
C4K17_RS19495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K17_RS19500	COG1733	regulation of RNA biosynthetic process
C4K17_RS19505	COG0583	DNA-binding transcription factor activity
C4K17_RS19520	COG0583	DNA-binding transcription factor activity
C4K17_RS19560	COG1126	abc transporter atp-binding protein
C4K17_RS19565	COG4597	amino acid ABC transporter
C4K17_RS19570	COG0765	amino acid transport
C4K17_RS19580	COG0583	DNA-binding transcription factor activity
C4K17_RS19600	COG4774	siderophore transport
C4K17_RS19625	COG2011	ABC-type metal ion transport system permease component
C4K17_RS19630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K17_RS19650	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS19655	COG1063	alcohol dehydrogenase
C4K17_RS19660	COG1024	Enoyl-CoA hydratase
C4K17_RS19665	COG4771	TonB-dependent receptor
C4K17_RS19685	COG2851	Citrate transporter
C4K17_RS19695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K17_RS19700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K17_RS19710	COG1414	Transcriptional regulator
C4K17_RS19715	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS19715	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K17_RS19735	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K17_RS19740	COG3971	2-oxopent-4-enoate hydratase activity
C4K17_RS19760	COG2721	sulfolactate sulfo-lyase activity
C4K17_RS19765	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS19770	COG0477	Major facilitator Superfamily
C4K17_RS19775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K17_RS19790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K17_RS19805	COG4608	Belongs to the ABC transporter superfamily
C4K17_RS19815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K17_RS19820	COG0601	transmembrane transport
C4K17_RS19825	COG0747	negative chemotaxis
C4K17_RS19835	COG3829	transcription factor binding
C4K17_RS19840	COG1454	alcohol dehydrogenase
C4K17_RS19855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K17_RS19860	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS19900	COG0322	excinuclease ABC activity
C4K17_RS19905	COG2197	response regulator
C4K17_RS19925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K17_RS19930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4K17_RS19935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K17_RS19940	COG4166	transmembrane transport
C4K17_RS19945	COG4174	ABC transporter (Permease)
C4K17_RS19950	COG4239	(ABC) transporter, permease
C4K17_RS19955	COG4172	Belongs to the ABC transporter superfamily
C4K17_RS19965	COG2610	gluconate transmembrane transporter activity
C4K17_RS19970	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS19975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K17_RS19985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K17_RS20025	COG1607	acyl-coa hydrolase
C4K17_RS20030	COG0069	glutamate synthase activity
C4K17_RS20035	COG2026	Addiction module toxin, RelE StbE family
C4K17_RS20065	COG2203	Gaf domain
C4K17_RS20065	COG2199	diguanylate cyclase activity
C4K17_RS20075	COG1253	flavin adenine dinucleotide binding
C4K17_RS20110	COG0583	DNA-binding transcription factor activity
C4K17_RS20170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4K17_RS20170	COG0316	Belongs to the HesB IscA family
C4K17_RS20205	COG0616	signal peptide processing
C4K17_RS20220	COG4172	Belongs to the ABC transporter superfamily
C4K17_RS20225	COG4239	(ABC) transporter, permease
C4K17_RS20230	COG4174	ABC transporter (Permease)
C4K17_RS20235	COG4166	transmembrane transport
C4K17_RS20240	COG4771	TonB-dependent receptor
C4K17_RS20245	COG4206	TonB-dependent receptor
C4K17_RS20255	COG1595	DNA-templated transcription, initiation
C4K17_RS20260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K17_RS20260	COG1024	Enoyl-CoA hydratase
C4K17_RS20285	COG2186	Transcriptional regulator
C4K17_RS20355	COG4191	Histidine kinase
C4K17_RS20355	COG0784	Response regulator, receiver
C4K17_RS20360	COG0587	DNA-directed DNA polymerase activity
C4K17_RS20375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K17_RS20395	COG2194	sulfuric ester hydrolase activity
C4K17_RS20400	COG0673	inositol 2-dehydrogenase activity
C4K17_RS20435	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS20445	COG0303	'Molybdopterin
C4K17_RS20450	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K17_RS20455	COG0746	molybdenum cofactor guanylyltransferase activity
C4K17_RS20460	COG0583	DNA-binding transcription factor activity
C4K17_RS20475	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K17_RS20480	COG3781	membrane
C4K17_RS20485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K17_RS20495	COG1271	oxidase subunit
C4K17_RS20500	COG1294	oxidase, subunit
C4K17_RS20515	COG0243	molybdopterin cofactor binding
C4K17_RS20520	COG0697	spore germination
C4K17_RS20525	COG1522	sequence-specific DNA binding
C4K17_RS20580	COG2989	Protein conserved in bacteria
C4K17_RS20595	COG3300	MHYT domain
C4K17_RS20595	COG5001	Diguanylate cyclase
C4K17_RS20605	COG1858	cytochrome C peroxidase
C4K17_RS20630	COG0579	oxidoreductase
C4K17_RS20680	COG2920	part of a sulfur-relay system
C4K17_RS20685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K17_RS20690	COG0435	Glutathione S-transferase
C4K17_RS20695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K17_RS20695	COG1648	precorrin-2 dehydrogenase activity
C4K17_RS20700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4K17_RS20705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4K17_RS20710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4K17_RS20715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4K17_RS20720	COG1674	ftsk spoiiie
C4K17_RS20725	COG0492	ferredoxin-NADP+ reductase activity
C4K17_RS20730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4K17_RS20735	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4K17_RS20740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4K17_RS20745	COG0542	response to heat
C4K17_RS20750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4K17_RS20755	COG1278	Cold shock
C4K17_RS20780	COG0482	sulfurtransferase activity
C4K17_RS20785	COG2915	High frequency lysogenization protein hflD homolog
C4K17_RS20795	COG2850	peptidyl-arginine hydroxylation
C4K17_RS20800	COG2153	protein acetylation
C4K17_RS20815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K17_RS20820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K17_RS20825	COG0649	NAD binding
C4K17_RS20825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K17_RS20840	COG1034	ATP synthesis coupled electron transport
C4K17_RS20845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4K17_RS20850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K17_RS20860	COG0713	ATP synthesis coupled electron transport
C4K17_RS20875	COG1007	ATP synthesis coupled electron transport
C4K17_RS20880	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4K17_RS20885	COG2944	sequence-specific DNA binding
C4K17_RS20900	COG0395	ABC-type sugar transport system, permease component
C4K17_RS20910	COG3842	ATPase activity
C4K17_RS20915	COG3842	ATPase activity
C4K17_RS20920	COG3284	Transcriptional regulator
C4K17_RS20935	COG0215	cysteine-tRNA ligase activity
C4K17_RS20940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K17_RS20950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K17_RS20955	COG2814	Major facilitator Superfamily
C4K17_RS20960	COG1566	PFAM secretion protein HlyD family protein
C4K17_RS20970	COG1846	Transcriptional regulator
C4K17_RS20975	COG2911	Protein conserved in bacteria
C4K17_RS20980	COG0729	surface antigen
C4K17_RS20990	COG0708	Exodeoxyribonuclease III
C4K17_RS21000	COG2885	chlorophyll binding
C4K17_RS21015	COG0789	Transcriptional regulator
C4K17_RS21030	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS21035	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS21040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K17_RS21055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K17_RS21065	COG2866	Carboxypeptidase
C4K17_RS21075	COG2814	Major facilitator Superfamily
C4K17_RS21080	COG3038	cytochrome b561
C4K17_RS21135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K17_RS21145	COG0217	transcriptional regulatory protein
C4K17_RS21150	COG0583	DNA-binding transcription factor activity
C4K17_RS21155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4K17_RS21160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K17_RS21165	COG3038	cytochrome b561
C4K17_RS21175	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS21175	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K17_RS21200	COG2814	Major facilitator Superfamily
C4K17_RS21205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K17_RS21215	COG0776	regulation of translation
C4K17_RS21220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K17_RS21225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4K17_RS21230	COG0740	serine-type endopeptidase activity
C4K17_RS21235	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4K17_RS21255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4K17_RS21260	COG1686	Belongs to the peptidase S11 family
C4K17_RS21270	COG1253	flavin adenine dinucleotide binding
C4K17_RS21280	COG0583	DNA-binding transcription factor activity
C4K17_RS21290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4K17_RS21300	COG3132	Protein of unknown function, DUF480
C4K17_RS21310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K17_RS21330	COG0628	permease
C4K17_RS21335	COG0826	peptidase U32
C4K17_RS21345	COG2056	Na+-H+ antiporter family
C4K17_RS21350	COG0840	transmembrane signaling receptor activity
C4K17_RS21380	COG0720	synthase
C4K17_RS21390	COG0596	Alpha beta hydrolase
C4K17_RS21400	COG1051	belongs to the nudix hydrolase family
C4K17_RS21415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K17_RS21420	COG0402	S-adenosylhomocysteine deaminase activity
C4K17_RS21425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K17_RS21440	COG1725	Transcriptional regulator
C4K17_RS21445	COG2207	Transcriptional regulator
C4K17_RS21455	COG0583	DNA-binding transcription factor activity
C4K17_RS21465	COG1522	sequence-specific DNA binding
C4K17_RS21475	COG2223	nitrite transmembrane transporter activity
C4K17_RS21480	COG4772	TonB-dependent receptor
C4K17_RS21490	COG1595	DNA-templated transcription, initiation
C4K17_RS21570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS21575	COG2274	protein secretion by the type I secretion system
C4K17_RS21580	COG1538	Outer membrane efflux protein
C4K17_RS21585	COG2080	2 iron, 2 sulfur cluster binding
C4K17_RS21590	COG2010	Cytochrome c
C4K17_RS21590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K17_RS21595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K17_RS21595	COG2010	Cytochrome c
C4K17_RS21610	COG0840	transmembrane signaling receptor activity
C4K17_RS21615	COG4774	siderophore transport
C4K17_RS21620	COG0583	DNA-binding transcription factor activity
C4K17_RS21630	COG3591	Belongs to the peptidase S1B family
C4K17_RS21630	COG1864	DNA RNA non-specific endonuclease
C4K17_RS21650	COG4106	trans-aconitate 2-methyltransferase activity
C4K17_RS21670	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4K17_RS21700	COG2814	Major facilitator Superfamily
C4K17_RS21730	COG3485	protocatechuate 3,4-dioxygenase
C4K17_RS21735	COG4829	muconolactone delta-isomerase
C4K17_RS21740	COG4948	Mandelate Racemase Muconate Lactonizing
C4K17_RS21835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4K17_RS21850	COG2814	Major facilitator Superfamily
C4K17_RS21880	COG0154	amidase activity
C4K17_RS21885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K17_RS21920	COG3012	SEC-C Motif Domain Protein
C4K17_RS21920	COG3318	Belongs to the UPF0149 family
C4K17_RS21925	COG0730	response to heat
C4K17_RS21950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K17_RS21960	COG1335	isochorismatase
C4K17_RS21965	COG1335	isochorismatase
C4K17_RS21975	COG0583	DNA-binding transcription factor activity
C4K17_RS21985	COG0656	L-ascorbic acid biosynthetic process
C4K17_RS22020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS22025	COG1136	(ABC) transporter
C4K17_RS22025	COG0577	efflux transmembrane transporter activity
C4K17_RS22030	COG1538	Outer membrane efflux protein
C4K17_RS22085	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4K17_RS22100	COG1309	transcriptional regulator
C4K17_RS22105	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS22110	COG3387	PFAM Glycoside hydrolase 15-related
C4K17_RS22125	COG0596	Alpha beta hydrolase
C4K17_RS22165	COG4977	sequence-specific DNA binding
C4K17_RS22175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K17_RS22180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4K17_RS22245	COG0840	transmembrane signaling receptor activity
C4K17_RS22280	COG1132	(ABC) transporter
C4K17_RS22285	COG3284	Transcriptional regulator
C4K17_RS22320	COG0583	DNA-binding transcription factor activity
C4K17_RS22325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K17_RS22330	COG0235	Class ii aldolase
C4K17_RS22335	COG0477	Major facilitator Superfamily
C4K17_RS22340	COG0583	DNA-binding transcription factor activity
C4K17_RS22345	COG0768	penicillin binding
C4K17_RS22355	COG1063	alcohol dehydrogenase
C4K17_RS22390	COG5006	permease, DMT superfamily
C4K17_RS22400	COG1309	transcriptional regulator
C4K17_RS22405	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS22430	COG0431	NADPH-dependent FMN reductase
C4K17_RS22435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS22445	COG3829	transcription factor binding
C4K17_RS22490	COG1121	(ABC) transporter
C4K17_RS22495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K17_RS22505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K17_RS22520	COG0642	Histidine kinase
C4K17_RS22530	COG4232	protein-disulfide reductase activity
C4K17_RS22535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4K17_RS22590	COG1309	transcriptional regulator
C4K17_RS22605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K17_RS22610	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS22630	COG3123	guanosine phosphorylase activity
C4K17_RS22635	COG0633	Ferredoxin
C4K17_RS22635	COG3217	Mosc domain protein beta barrel domain protein
C4K17_RS22650	COG3851	Histidine kinase
C4K17_RS22655	COG2197	response regulator
C4K17_RS22660	COG1597	lipid kinase activity
C4K17_RS22670	COG0303	'Molybdopterin
C4K17_RS22675	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K17_RS22680	COG0746	molybdenum cofactor guanylyltransferase activity
C4K17_RS22690	COG0564	pseudouridine synthase activity
C4K17_RS22715	COG0004	ammonium transporteR
C4K17_RS22735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K17_RS22755	COG2197	response regulator
C4K17_RS22760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS22760	COG2205	protein histidine kinase activity
C4K17_RS22765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4K17_RS22770	COG1956	GAF domain-containing protein
C4K17_RS22780	COG5002	protein histidine kinase activity
C4K17_RS22780	COG2205	protein histidine kinase activity
C4K17_RS22780	COG0784	Response regulator, receiver
C4K17_RS22785	COG1846	Transcriptional regulator
C4K17_RS22790	COG0386	Belongs to the glutathione peroxidase family
C4K17_RS22795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K17_RS22800	COG0436	Aminotransferase
C4K17_RS22805	COG0501	Belongs to the peptidase M48B family
C4K17_RS22815	COG3384	dioxygenase
C4K17_RS22830	COG1024	Enoyl-CoA hydratase
C4K17_RS22840	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4K17_RS22845	COG3214	Protein conserved in bacteria
C4K17_RS22855	COG0583	DNA-binding transcription factor activity
C4K17_RS22865	COG0583	DNA-binding transcription factor activity
C4K17_RS22870	COG1846	Transcriptional regulator
C4K17_RS22875	COG1764	response to oxidative stress
C4K17_RS22885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4K17_RS22900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K17_RS22920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K17_RS22950	COG1376	ErfK ybiS ycfS ynhG family protein
C4K17_RS22965	COG4181	ATPase activity
C4K17_RS22970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4K17_RS22975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K17_RS22990	COG2197	response regulator
C4K17_RS23000	COG2259	Doxx family
C4K17_RS23005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K17_RS23010	COG0084	hydrolase, TatD family'
C4K17_RS23045	COG0745	RESPONSE REGULATOR receiver
C4K17_RS23050	COG2205	protein histidine kinase activity
C4K17_RS23055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4K17_RS23065	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4K17_RS23100	COG4221	oxidoreductase activity
C4K17_RS23115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K17_RS23135	COG0776	regulation of translation
C4K17_RS23150	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4K17_RS23155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4K17_RS23160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K17_RS23170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4K17_RS23180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4K17_RS23185	COG0402	S-adenosylhomocysteine deaminase activity
C4K17_RS23190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K17_RS23195	COG0546	phosphoglycolate phosphatase activity
C4K17_RS23200	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS23215	COG5002	protein histidine kinase activity
C4K17_RS23215	COG5001	Diguanylate cyclase
C4K17_RS23230	COG1054	Belongs to the UPF0176 family
C4K17_RS23235	COG0271	Belongs to the BolA IbaG family
C4K17_RS23245	COG0114	fumarate hydratase activity
C4K17_RS23250	COG0697	spore germination
C4K17_RS23255	COG0183	Belongs to the thiolase family
C4K17_RS23260	COG2326	polyphosphate kinase activity
C4K17_RS23265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS23265	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4K17_RS23270	COG0367	asparagine synthase
C4K17_RS23275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K17_RS23275	COG0189	ligase activity
C4K17_RS23280	COG1363	Peptidase, m42
C4K17_RS23285	COG3089	Belongs to the UPF0270 family
C4K17_RS23290	COG1742	UPF0060 membrane protein
C4K17_RS23305	COG1368	sulfuric ester hydrolase activity
C4K17_RS23325	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS23335	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C4K17_RS23340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4K17_RS23345	COG0235	Class ii aldolase
C4K17_RS23355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4K17_RS23360	COG1073	alpha beta
C4K17_RS23385	COG2840	Smr protein MutS2
C4K17_RS23390	COG0302	gtp cyclohydrolase
C4K17_RS23400	COG0625	glutathione transferase activity
C4K17_RS23405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K17_RS23415	COG2252	PERMEase
C4K17_RS23440	COG4266	Belongs to the allantoicase family
C4K17_RS23445	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4K17_RS23455	COG2233	PERMEase
C4K17_RS23480	COG1560	Kdo2-lipid A biosynthetic process
C4K17_RS23485	COG0850	regulation of cytokinetic process
C4K17_RS23490	COG2894	cell division
C4K17_RS23495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4K17_RS23500	COG0564	pseudouridine synthase activity
C4K17_RS23510	COG1362	aminopeptidase activity
C4K17_RS23515	COG0668	transmembrane transport
C4K17_RS23520	COG1473	amidohydrolase
C4K17_RS23550	COG3842	ATPase activity
C4K17_RS23560	COG0604	alcohol dehydrogenase
C4K17_RS23560	COG4221	oxidoreductase activity
C4K17_RS23560	COG3321	synthase
C4K17_RS23560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K17_RS23570	COG2200	EAL domain
C4K17_RS23595	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K17_RS23600	COG2010	Cytochrome c
C4K17_RS23630	COG2974	May be involved in recombination
C4K17_RS23635	COG0385	Bile acid
C4K17_RS23640	COG2076	Multidrug Resistance protein
C4K17_RS23670	COG2205	protein histidine kinase activity
C4K17_RS23670	COG2202	Pas domain
C4K17_RS23720	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4K17_RS23725	COG0406	alpha-ribazole phosphatase activity
C4K17_RS23730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4K17_RS23740	COG1492	cobalamin metabolic process
C4K17_RS23755	COG0778	Nitroreductase
C4K17_RS23760	COG1797	cobyrinic acid a,c-diamide synthase activity
C4K17_RS23785	COG0791	NLP P60 protein
C4K17_RS23790	COG0791	NLP P60 protein
C4K17_RS23795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K17_RS23800	COG0628	permease
C4K17_RS23810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4K17_RS23815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4K17_RS23830	COG3122	Protein conserved in bacteria
C4K17_RS23835	COG3956	TIGRFAM MazG family protein
C4K17_RS23840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K17_RS23845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K17_RS23865	COG5002	protein histidine kinase activity
C4K17_RS23865	COG2205	protein histidine kinase activity
C4K17_RS23865	COG0784	Response regulator, receiver
C4K17_RS23870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K17_RS23890	COG1393	Belongs to the ArsC family
C4K17_RS23910	COG0037	tRNA processing
C4K17_RS23920	COG3091	SprT-like family
C4K17_RS23925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K17_RS23965	COG2205	protein histidine kinase activity
C4K17_RS23970	COG0745	RESPONSE REGULATOR receiver
C4K17_RS23975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K17_RS23975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K17_RS23990	COG1558	bacterial-type flagellum-dependent cell motility
C4K17_RS23995	COG1815	bacterial-type flagellum-dependent cell motility
C4K17_RS24000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K17_RS24005	COG0835	chemotaxis
C4K17_RS24005	COG0784	Response regulator, receiver
C4K17_RS24025	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4K17_RS24030	COG0477	Major facilitator Superfamily
C4K17_RS24040	COG2205	protein histidine kinase activity
C4K17_RS24070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K17_RS24100	COG2239	Acts as a magnesium transporter
C4K17_RS24120	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K17_RS24125	COG0527	aspartate kinase activity
C4K17_RS24130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K17_RS24135	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4K17_RS24140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K17_RS24145	COG2988	succinylglutamate desuccinylase activity
C4K17_RS24155	COG3724	N-succinylarginine dihydrolase activity
C4K17_RS24160	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS24175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K17_RS24205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS24210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K17_RS24220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K17_RS24255	COG0563	adenylate kinase activity
C4K17_RS24270	COG3706	GGDEF domain
C4K17_RS24290	COG0504	CTP synthase activity
C4K17_RS24295	COG2329	Antibiotic biosynthesis monooxygenase
C4K17_RS24305	COG0584	glycerophosphoryl diester phosphodiesterase
C4K17_RS24335	COG0306	phosphate transporter
C4K17_RS24345	COG3008	intermembrane lipid transfer
C4K17_RS24350	COG2995	paraquat-inducible protein a
C4K17_RS24355	COG2995	paraquat-inducible protein a
C4K17_RS24370	COG0583	DNA-binding transcription factor activity
C4K17_RS24375	COG4941	Belongs to the sigma-70 factor family
C4K17_RS24385	COG3795	YCII-related domain
C4K17_RS24430	COG0436	Aminotransferase
C4K17_RS24440	COG3265	gluconokinase activity
C4K17_RS24445	COG1609	Transcriptional regulator
C4K17_RS24450	COG0583	DNA-binding transcription factor activity
C4K17_RS24460	COG0625	glutathione transferase activity
C4K17_RS24465	COG0477	Major facilitator Superfamily
C4K17_RS24475	COG0583	DNA-binding transcription factor activity
C4K17_RS24485	COG2986	histidine ammonia-lyase
C4K17_RS24495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS24510	COG3712	iron ion homeostasis
C4K17_RS24515	COG1595	DNA-templated transcription, initiation
C4K17_RS24540	COG0242	peptide deformylase activity
C4K17_RS24545	COG1295	ribonuclease BN
C4K17_RS24560	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS24565	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS24570	COG2267	carboxylic ester hydrolase activity
C4K17_RS24575	COG2030	dehydratase
C4K17_RS24600	COG3530	Putative quorum-sensing-regulated virulence factor
C4K17_RS24605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K17_RS24610	COG0800	Aldolase
C4K17_RS24625	COG1737	Transcriptional regulator
C4K17_RS24630	COG0676	glucose-6-phosphate 1-epimerase activity
C4K17_RS24640	COG3842	ATPase activity
C4K17_RS24645	COG0395	ABC-type sugar transport system, permease component
C4K17_RS24650	COG1175	transmembrane transport
C4K17_RS24655	COG1653	transport
C4K17_RS24690	COG1803	Methylglyoxal synthase
C4K17_RS24700	COG3712	iron ion homeostasis
C4K17_RS24705	COG4771	TonB-dependent receptor
C4K17_RS24715	COG2832	Protein of unknown function (DUF454)
C4K17_RS24720	COG0840	transmembrane signaling receptor activity
C4K17_RS24725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K17_RS24750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K17_RS24770	COG0509	glycine decarboxylation via glycine cleavage system
C4K17_RS24775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K17_RS24775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K17_RS24780	COG1760	l-serine dehydratase
C4K17_RS24790	COG1278	Cold shock
C4K17_RS24800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4K17_RS24805	COG4964	Belongs to the GSP D family
C4K17_RS24895	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K17_RS24900	COG1129	ABC transporter
C4K17_RS24905	COG1879	ABC-type sugar transport system periplasmic component
C4K17_RS24915	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS24965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K17_RS24970	COG0602	queuosine metabolic process
C4K17_RS24975	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4K17_RS24980	COG2885	chlorophyll binding
C4K17_RS24985	COG0823	Involved in the tonB-independent uptake of proteins
C4K17_RS25005	COG0824	Thioesterase
C4K17_RS25010	COG2255	four-way junction helicase activity
C4K17_RS25015	COG0632	four-way junction helicase activity
C4K17_RS25020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4K17_RS25025	COG0217	transcriptional regulatory protein
C4K17_RS25030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4K17_RS25040	COG0783	Belongs to the Dps family
C4K17_RS25050	COG2900	Belongs to the SlyX family
C4K17_RS25070	COG0668	transmembrane transport
C4K17_RS25075	COG1666	GTP binding
C4K17_RS25085	COG4191	Histidine kinase
C4K17_RS25085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS25090	COG2096	Adenosyltransferase
C4K17_RS25095	COG0352	thiamine-phosphate diphosphorylase activity
C4K17_RS25105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4K17_RS25110	COG0653	protein targeting
C4K17_RS25120	COG0433	COG0433 Predicted ATPase
C4K17_RS25130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K17_RS25130	COG0438	transferase activity, transferring glycosyl groups
C4K17_RS25160	COG2925	Exonuclease
C4K17_RS25185	COG0714	Associated with various cellular activities
C4K17_RS25205	COG0469	pyruvate kinase activity
C4K17_RS25220	COG3706	GGDEF domain
C4K17_RS25235	COG4191	Histidine kinase
C4K17_RS25245	COG0477	Major facilitator Superfamily
C4K17_RS25275	COG2207	Transcriptional regulator
C4K17_RS25280	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS25290	COG0583	DNA-binding transcription factor activity
C4K17_RS25295	COG2910	NAD(P)H-binding
C4K17_RS25305	COG0583	DNA-binding transcription factor activity
C4K17_RS25335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K17_RS25340	COG0583	DNA-binding transcription factor activity
C4K17_RS25355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4K17_RS25385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS25390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K17_RS25400	COG3642	lipopolysaccharide core region biosynthetic process
C4K17_RS25410	COG0642	Histidine kinase
C4K17_RS25425	COG0459	protein refolding
C4K17_RS25430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4K17_RS25440	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4K17_RS25450	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS25455	COG0489	protein tyrosine kinase activity
C4K17_RS25460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K17_RS25460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K17_RS25465	COG4657	Part of a membrane complex involved in electron transport
C4K17_RS25470	COG2878	Part of a membrane complex involved in electron transport
C4K17_RS25475	COG4658	electron transport chain
C4K17_RS25485	COG4660	Part of a membrane complex involved in electron transport
C4K17_RS25490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4K17_RS25500	COG2197	response regulator
C4K17_RS25505	COG0137	argininosuccinate synthase activity
C4K17_RS25515	COG0418	dihydroorotase activity
C4K17_RS25520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K17_RS25525	COG0450	alkyl hydroperoxide reductase
C4K17_RS25540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4K17_RS25545	COG3383	formate dehydrogenase (NAD+) activity
C4K17_RS25555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K17_RS25560	COG3842	ATPase activity
C4K17_RS25570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4K17_RS25580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4K17_RS25605	COG0765	amino acid transport
C4K17_RS25610	COG0765	amino acid transport
C4K17_RS25615	COG1126	abc transporter atp-binding protein
C4K17_RS25645	COG2076	Multidrug Resistance protein
C4K17_RS25665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K17_RS25680	COG4191	Histidine kinase
C4K17_RS25685	COG2204	response regulator
C4K17_RS25690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K17_RS25695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4K17_RS25700	COG0583	DNA-binding transcription factor activity
C4K17_RS25705	COG0456	acetyltransferase
C4K17_RS25710	COG1280	lysine exporter protein (LysE YggA)
C4K17_RS25720	COG0254	rRNA binding
C4K17_RS25725	COG2197	response regulator
C4K17_RS25730	COG0069	glutamate synthase activity
C4K17_RS25755	COG2246	polysaccharide biosynthetic process
C4K17_RS25770	COG1113	amino acid transport
C4K17_RS25780	COG1695	Transcriptional regulator
C4K17_RS25785	COG2375	cellular response to nickel ion
C4K17_RS25795	COG4628	conserved protein (DUF2132)
C4K17_RS25800	COG4206	TonB-dependent receptor
C4K17_RS25835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K17_RS25850	COG2226	methyltransferase
C4K17_RS25855	COG0500	methyltransferase
C4K17_RS25860	COG0590	tRNA wobble adenosine to inosine editing
C4K17_RS25875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K17_RS25875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K17_RS25885	COG0366	Alpha amylase catalytic
C4K17_RS25890	COG1263	PTS System
C4K17_RS25890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K17_RS25895	COG2188	Transcriptional regulator
C4K17_RS25920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K17_RS25920	COG0519	Catalyzes the synthesis of GMP from XMP
C4K17_RS25945	COG1570	exodeoxyribonuclease VII activity
C4K17_RS25950	COG0739	heme binding
C4K17_RS25955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K17_RS25970	COG0436	Aminotransferase
C4K17_RS25975	COG1160	GTP binding
C4K17_RS25990	COG0124	histidyl-tRNA synthetase
C4K17_RS25995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4K17_RS26000	COG1426	Protein conserved in bacteria
C4K17_RS26010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4K17_RS26015	COG0105	UTP biosynthetic process
C4K17_RS26025	COG0633	Ferredoxin
C4K17_RS26030	COG0443	Heat shock 70 kDa protein
C4K17_RS26035	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K17_RS26050	COG1104	cysteine desulfurase activity
C4K17_RS26060	COG1045	serine acetyltransferase
C4K17_RS26075	COG3134	Outer membrane lipoprotein
C4K17_RS26090	COG1862	Preprotein translocase
C4K17_RS26095	COG0343	queuine tRNA-ribosyltransferase activity
C4K17_RS26100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4K17_RS26125	COG2853	Lipoprotein
C4K17_RS26235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K17_RS26250	COG5322	oxidoreductase activity
C4K17_RS26250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K17_RS26255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K17_RS26260	COG2771	luxR family
C4K17_RS26265	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS26285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K17_RS26300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K17_RS26305	COG0109	protoheme IX farnesyltransferase activity
C4K17_RS26315	COG1845	cytochrome c oxidase, subunit III
C4K17_RS26320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K17_RS26325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K17_RS26335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K17_RS26345	COG1017	nitric oxide dioxygenase activity
C4K17_RS26345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K17_RS26350	COG3604	Transcriptional regulator
C4K17_RS26355	COG0784	Response regulator, receiver
C4K17_RS26355	COG0835	chemotaxis
C4K17_RS26385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K17_RS26395	COG5002	protein histidine kinase activity
C4K17_RS26410	COG4251	negative regulation of phosphorylation
C4K17_RS26410	COG2203	Gaf domain
C4K17_RS26410	COG5001	Diguanylate cyclase
C4K17_RS26410	COG3706	GGDEF domain
C4K17_RS26415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4K17_RS26420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4K17_RS26435	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K17_RS26440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K17_RS26445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K17_RS26450	COG0772	Belongs to the SEDS family
C4K17_RS26455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4K17_RS26460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K17_RS26465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4K17_RS26470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K17_RS26485	COG0275	rRNA processing
C4K17_RS26490	COG2001	Belongs to the MraZ family
C4K17_RS26505	COG3107	peptidoglycan biosynthetic process
C4K17_RS26510	COG0792	nuclease activity
C4K17_RS26515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4K17_RS26520	COG2823	Periplasmic or secreted lipoprotein
C4K17_RS26525	COG2969	positive regulation of protein catabolic process
C4K17_RS26530	COG0625	glutathione transferase activity
C4K17_RS26535	COG2857	Cytochrome c1
C4K17_RS26540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4K17_RS26545	COG0723	plastoquinol--plastocyanin reductase activity
C4K17_RS26550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4K17_RS26555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4K17_RS26560	COG0667	Aldo Keto reductase
C4K17_RS26565	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS26575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K17_RS26580	COG0180	Tryptophanyl-tRNA synthetase
C4K17_RS26600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K17_RS26615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4K17_RS26625	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS26655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K17_RS26665	COG2771	luxR family
C4K17_RS26670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K17_RS26685	COG0745	RESPONSE REGULATOR receiver
C4K17_RS26690	COG0642	Histidine kinase
C4K17_RS26695	COG2909	trisaccharide binding
C4K17_RS26710	COG0318	PFAM AMP-dependent synthetase and ligase
C4K17_RS26715	COG2814	Major facilitator Superfamily
C4K17_RS26730	COG1280	lysine exporter protein (LysE YggA)
C4K17_RS26735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K17_RS26740	COG2813	Specifically methylates the guanine in position
C4K17_RS26745	COG2119	membrane
C4K17_RS26750	COG0501	Belongs to the peptidase M48B family
C4K17_RS26755	COG0840	transmembrane signaling receptor activity
C4K17_RS26760	COG2135	peptidase activity
C4K17_RS26820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4K17_RS26825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4K17_RS26835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4K17_RS26840	COG1090	epimerase
C4K17_RS26845	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4K17_RS26855	COG0789	Transcriptional regulator
C4K17_RS26860	COG0415	Belongs to the DNA photolyase family
C4K17_RS26875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4K17_RS26880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4K17_RS26890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4K17_RS26895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4K17_RS26905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4K17_RS26910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4K17_RS26920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4K17_RS26925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4K17_RS26930	COG0193	aminoacyl-tRNA hydrolase activity
C4K17_RS26945	COG0583	DNA-binding transcription factor activity
C4K17_RS26950	COG2197	response regulator
C4K17_RS26955	COG2205	protein histidine kinase activity
C4K17_RS26955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS26960	COG3397	chitin binding
C4K17_RS27025	COG2258	MOSC domain
C4K17_RS27030	COG2223	nitrite transmembrane transporter activity
C4K17_RS27035	COG0583	DNA-binding transcription factor activity
C4K17_RS27040	COG3842	ATPase activity
C4K17_RS27045	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K17_RS27050	COG1177	transmembrane transport
C4K17_RS27120	COG0405	Gamma-glutamyltransferase
C4K17_RS27135	COG4680	protein conserved in bacteria
C4K17_RS27150	COG0789	Transcriptional regulator
C4K17_RS27165	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K17_RS27180	COG3655	Transcriptional regulator
C4K17_RS27200	COG0662	Cupin 2, conserved barrel domain protein
C4K17_RS27210	COG0583	DNA-binding transcription factor activity
C4K17_RS27215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K17_RS27220	COG1028	Short-chain dehydrogenase reductase Sdr
C4K17_RS27225	COG0583	DNA-binding transcription factor activity
C4K17_RS27295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K17_RS27310	COG2031	fatty acid transporter
C4K17_RS27325	COG0288	reversible hydration of carbon dioxide
C4K17_RS27335	COG0456	acetyltransferase
C4K17_RS27360	COG3008	intermembrane lipid transfer
C4K17_RS27365	COG2995	paraquat-inducible protein a
C4K17_RS27370	COG2995	paraquat-inducible protein a
C4K17_RS27405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4K17_RS27410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4K17_RS27415	COG1183	phosphatidylcholine synthase activity
C4K17_RS27420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4K17_RS27430	COG0028	Belongs to the TPP enzyme family
C4K17_RS27450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K17_RS27480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4K17_RS27485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K17_RS27490	COG4558	Periplasmic binding protein
C4K17_RS27500	COG1489	DNA binding
C4K17_RS27505	COG0436	Aminotransferase
C4K17_RS27515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K17_RS27525	COG4191	Histidine kinase
C4K17_RS27550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K17_RS27555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4K17_RS27565	COG0166	Belongs to the GPI family
C4K17_RS27570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K17_RS27585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K17_RS27595	COG2823	Periplasmic or secreted lipoprotein
C4K17_RS27610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4K17_RS27615	COG0237	dephospho-CoA kinase activity
C4K17_RS27620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4K17_RS27640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K17_RS27695	COG0728	peptidoglycan biosynthetic process
C4K17_RS27710	COG1252	NADH dehydrogenase
C4K17_RS27720	COG3121	Chaperone
C4K17_RS27725	COG3188	usher protein
C4K17_RS27755	COG0542	response to heat
C4K17_RS27785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS27825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4K17_RS27830	COG1047	Peptidyl-prolyl cis-trans
C4K17_RS27835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4K17_RS27840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4K17_RS27845	COG0196	riboflavin kinase activity
C4K17_RS27860	COG0268	Binds directly to 16S ribosomal RNA
C4K17_RS27865	COG3045	CreA protein
C4K17_RS27870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4K17_RS27875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4K17_RS27880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4K17_RS27885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4K17_RS27890	COG0142	geranyltranstransferase activity
C4K17_RS27895	COG2824	Alkylphosphonate utilization operon protein PhnA
C4K17_RS27900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K17_RS27905	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K17_RS27915	COG2862	Uncharacterized protein family, UPF0114
C4K17_RS27930	COG1067	ATP-dependent peptidase activity
C4K17_RS27950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K17_RS27960	COG0488	(ABC) transporter
C4K17_RS27970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K17_RS27985	COG2186	Transcriptional regulator
C4K17_RS27995	COG0523	cobalamin synthesis protein
C4K17_RS28000	COG2879	small protein
C4K17_RS28005	COG1966	Carbon starvation protein
C4K17_RS28010	COG2020	methyltransferase activity
C4K17_RS28040	COG1970	mechanosensitive ion channel activity
C4K17_RS28050	COG2813	Specifically methylates the guanine in position
C4K17_RS28060	COG1294	oxidase, subunit
C4K17_RS28065	COG1271	oxidase subunit
C4K17_RS28090	COG2252	PERMEase
C4K17_RS28095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K17_RS28100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K17_RS28105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K17_RS28110	COG3135	benzoate transporter
C4K17_RS28120	COG1309	transcriptional regulator
C4K17_RS28125	COG1082	Xylose isomerase domain protein TIM barrel
C4K17_RS28125	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4K17_RS28145	COG0673	inositol 2-dehydrogenase activity
C4K17_RS28155	COG1053	succinate dehydrogenase
C4K17_RS28160	COG3485	protocatechuate 3,4-dioxygenase
C4K17_RS28165	COG3485	protocatechuate 3,4-dioxygenase
C4K17_RS28170	COG0583	DNA-binding transcription factor activity
C4K17_RS28175	COG2321	neutral zinc metallopeptidase
C4K17_RS28190	COG1946	Acyl-CoA thioesterase
C4K17_RS28200	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4K17_RS28210	COG0513	Belongs to the DEAD box helicase family
C4K17_RS28220	COG0697	spore germination
C4K17_RS28225	COG1522	sequence-specific DNA binding
C4K17_RS28230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K17_RS28230	COG1199	ATP-dependent helicase activity
C4K17_RS28240	COG3416	Protein conserved in bacteria
C4K17_RS28255	COG1643	Atp-dependent helicase
C4K17_RS28275	COG1522	sequence-specific DNA binding
C4K17_RS28290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K17_RS28295	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS28300	COG2205	protein histidine kinase activity
C4K17_RS28300	COG0784	Response regulator, receiver
C4K17_RS28300	COG2198	Histidine kinase
C4K17_RS28305	COG0351	phosphomethylpyrimidine kinase
C4K17_RS28310	COG0352	thiamine-phosphate diphosphorylase activity
C4K17_RS28315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K17_RS28330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K17_RS28335	COG1702	phosphate starvation-inducible protein PhoH
C4K17_RS28340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4K17_RS28345	COG4535	Mg2 and Co2 transporter CorC
C4K17_RS28355	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4K17_RS28370	COG0495	leucyl-tRNA aminoacylation
C4K17_RS28390	COG2951	lytic endotransglycosylase activity
C4K17_RS28395	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4K17_RS28400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4K17_RS28405	COG0321	lipoyl(octanoyl) transferase activity
C4K17_RS28410	COG2921	Belongs to the UPF0250 family
C4K17_RS28415	COG1686	Belongs to the peptidase S11 family
C4K17_RS28425	COG2951	lytic endotransglycosylase activity
C4K17_RS28430	COG0772	Belongs to the SEDS family
C4K17_RS28435	COG0768	penicillin binding
C4K17_RS28440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4K17_RS28450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4K17_RS28455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4K17_RS28460	COG2094	Belongs to the DNA glycosylase MPG family
C4K17_RS28465	COG0586	Pfam SNARE associated Golgi protein
C4K17_RS28475	COG1346	cytolysis
C4K17_RS28495	COG0702	epimerase
C4K17_RS28510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K17_RS28515	COG3284	Transcriptional regulator
C4K17_RS28530	COG4303	Ethanolamine ammonia lyase large subunit
C4K17_RS28535	COG4302	ethanolamine ammonia-lyase activity
C4K17_RS28540	COG0456	acetyltransferase
C4K17_RS28545	COG0586	Pfam SNARE associated Golgi protein
C4K17_RS28550	COG3228	Belongs to the MtfA family
C4K17_RS28555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4K17_RS28570	COG2070	2-Nitropropane dioxygenase
C4K17_RS28580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K17_RS28585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS28590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K17_RS28595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K17_RS28595	COG0473	3-isopropylmalate dehydrogenase activity
C4K17_RS28600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K17_RS28610	COG2814	Major facilitator Superfamily
C4K17_RS28625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS28640	COG0583	DNA-binding transcription factor activity
C4K17_RS28645	COG2207	Transcriptional regulator
C4K17_RS28655	COG3657	addiction module killer protein
C4K17_RS28665	COG3321	synthase
C4K17_RS28665	COG0604	alcohol dehydrogenase
C4K17_RS28670	COG0640	Transcriptional regulator
C4K17_RS28680	COG1722	exodeoxyribonuclease VII activity
C4K17_RS28685	COG0142	geranyltranstransferase activity
C4K17_RS28690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4K17_RS28695	COG4206	TonB-dependent receptor
C4K17_RS28700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K17_RS28710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4K17_RS28720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4K17_RS28730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4K17_RS28735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K17_RS28750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K17_RS28750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K17_RS28755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K17_RS28765	COG2264	protein methyltransferase activity
C4K17_RS28770	COG3118	belongs to the thioredoxin family
C4K17_RS28800	COG3047	cAMP biosynthetic process
C4K17_RS28815	COG1201	RNA secondary structure unwinding
C4K17_RS28820	COG2814	Major facilitator Superfamily
C4K17_RS28830	COG3568	Endonuclease Exonuclease Phosphatase
C4K17_RS28835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K17_RS28840	COG0392	lysyltransferase activity
C4K17_RS28860	COG1335	isochorismatase
C4K17_RS28865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K17_RS28910	COG0629	single-stranded DNA binding
C4K17_RS28915	COG2814	Major facilitator Superfamily
C4K17_RS28920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4K17_RS28925	COG2193	ferroxidase activity
C4K17_RS28935	COG0203	ribosomal protein L17
C4K17_RS28940	COG0202	RNA polymerase activity
C4K17_RS28945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4K17_RS28950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4K17_RS28955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4K17_RS28960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4K17_RS28970	COG0200	Binds to the 23S rRNA
C4K17_RS28975	COG1841	ribosomal large subunit assembly
C4K17_RS28980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4K17_RS28985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4K17_RS28990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4K17_RS28995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4K17_RS29000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4K17_RS29005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4K17_RS29010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4K17_RS29015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4K17_RS29020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4K17_RS29025	COG0255	Belongs to the universal ribosomal protein uL29 family
C4K17_RS29030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4K17_RS29035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4K17_RS29040	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4K17_RS29045	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4K17_RS29050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4K17_RS29055	COG0089	rRNA binding
C4K17_RS29060	COG0088	Forms part of the polypeptide exit tunnel
C4K17_RS29065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4K17_RS29070	COG0051	transcription antitermination factor activity, RNA binding
C4K17_RS29075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K17_RS29080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K17_RS29085	COG0049	tRNA binding
C4K17_RS29090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4K17_RS29095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4K17_RS29100	COG0085	RNA polymerase activity
C4K17_RS29105	COG0222	ribosome binding
C4K17_RS29110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4K17_RS29115	COG0081	regulation of translation
C4K17_RS29120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4K17_RS29140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K17_RS29205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4K17_RS29210	COG0739	heme binding
C4K17_RS29215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4K17_RS29220	COG0316	Belongs to the HesB IscA family
C4K17_RS29225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K17_RS29230	COG1981	membrane
C4K17_RS29245	COG4221	oxidoreductase activity
C4K17_RS29250	COG0537	adenosine 5'-monophosphoramidase activity
C4K17_RS29255	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4K17_RS29260	COG1765	OsmC-like protein
C4K17_RS29275	COG0134	indole-3-glycerol-phosphate synthase activity
C4K17_RS29280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K17_RS29285	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K17_RS29295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K17_RS29300	COG0546	phosphoglycolate phosphatase activity
C4K17_RS29305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4K17_RS29310	COG1454	alcohol dehydrogenase
C4K17_RS29320	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K17_RS29330	COG3842	ATPase activity
C4K17_RS29335	COG2197	response regulator
C4K17_RS29340	COG4585	Histidine kinase
C4K17_RS29350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K17_RS29355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K17_RS29360	COG3178	'Phosphotransferase
C4K17_RS29365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4K17_RS29370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K17_RS29375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4K17_RS29380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4K17_RS29385	COG2967	ApaG domain
C4K17_RS29390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K17_RS29395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K17_RS29400	COG2766	serine protein kinase
C4K17_RS29405	COG2718	Belongs to the UPF0229 family
C4K17_RS29410	COG2719	SpoVR family
C4K17_RS29415	COG0617	tRNA 3'-terminal CCA addition
C4K17_RS29425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K17_RS29430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4K17_RS29435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4K17_RS29440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4K17_RS29445	COG0358	DNA primase activity
C4K17_RS29450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4K17_RS29485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K17_RS29490	COG1025	Belongs to the peptidase M16 family
C4K17_RS29500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K17_RS29505	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4K17_RS29515	COG0535	radical SAM domain protein
C4K17_RS29540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K17_RS29545	COG2258	MOSC domain
C4K17_RS29550	COG0583	DNA-binding transcription factor activity
C4K17_RS29555	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS29560	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS29565	COG3706	GGDEF domain
C4K17_RS29570	COG1960	acyl-CoA dehydrogenase activity
C4K17_RS29590	COG2226	methyltransferase
C4K17_RS29590	COG1073	alpha beta
C4K17_RS29595	COG0156	8-amino-7-oxononanoate synthase activity
C4K17_RS29600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4K17_RS29610	COG3585	molybdate ion transport
C4K17_RS29610	COG2005	Transcriptional regulator
C4K17_RS29620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4K17_RS29635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4K17_RS29655	COG1595	DNA-templated transcription, initiation
C4K17_RS29660	COG3712	iron ion homeostasis
C4K17_RS29665	COG4774	siderophore transport
C4K17_RS29685	COG0625	glutathione transferase activity
C4K17_RS29690	COG4452	Inner membrane protein CreD
C4K17_RS29695	COG2205	protein histidine kinase activity
C4K17_RS29700	COG0745	RESPONSE REGULATOR receiver
C4K17_RS29705	COG0189	ligase activity
C4K17_RS29705	COG4067	protein conserved in archaea
C4K17_RS29710	COG0204	Acyl-transferase
C4K17_RS29740	COG1063	alcohol dehydrogenase
C4K17_RS29770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K17_RS29785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K17_RS29800	COG1017	nitric oxide dioxygenase activity
C4K17_RS29800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K17_RS29810	COG4638	Rieske (2fe-2S)
C4K17_RS29820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4K17_RS29825	COG0247	lactate metabolic process
C4K17_RS29825	COG2181	nitrate reductase activity
C4K17_RS29830	COG1902	pentaerythritol trinitrate reductase activity
C4K17_RS29830	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K17_RS29880	COG3246	L-lysine catabolic process to acetate
C4K17_RS29885	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K17_RS29915	COG1760	l-serine dehydratase
C4K17_RS29925	COG4176	ABC-type proline glycine betaine transport system permease component
C4K17_RS29930	COG4175	Glycine betaine
C4K17_RS29935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K17_RS29940	COG1309	transcriptional regulator
C4K17_RS29945	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS29950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K17_RS29965	COG0312	modulator of DNA gyrase
C4K17_RS29970	COG0477	Major facilitator Superfamily
C4K17_RS29975	COG0513	Belongs to the DEAD box helicase family
C4K17_RS29980	COG2081	HI0933 family
C4K17_RS29985	COG1289	transmembrane transporter activity
C4K17_RS29995	COG2153	protein acetylation
C4K17_RS30005	COG1451	nucleotide metabolic process
C4K17_RS30035	COG0126	phosphoglycerate kinase activity
C4K17_RS30040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4K17_RS30050	COG4106	trans-aconitate 2-methyltransferase activity
C4K17_RS30055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4K17_RS30065	COG1422	Protein of unknown function (DUF1090)
C4K17_RS30090	COG2814	Major facilitator Superfamily
C4K17_RS30100	COG2116	formate transmembrane transporter activity
C4K17_RS30110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4K17_RS30115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4K17_RS30130	COG0513	Belongs to the DEAD box helicase family
C4K17_RS30135	COG2353	YceI-like domain
C4K17_RS30140	COG3038	cytochrome b561
C4K17_RS30150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4K17_RS30175	COG1272	protein, Hemolysin III
C4K17_RS30195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K17_RS30215	COG3052	prosthetic group binding
C4K17_RS30220	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4K17_RS30245	COG2198	Histidine kinase
C4K17_RS30245	COG0784	Response regulator, receiver
C4K17_RS30245	COG0643	Histidine kinase
C4K17_RS30270	COG0189	ligase activity
C4K17_RS30280	COG1678	Uncharacterized ACR, COG1678
C4K17_RS30285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4K17_RS30290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4K17_RS30295	COG0540	Belongs to the ATCase OTCase family
C4K17_RS30300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K17_RS30310	COG0791	NLP P60 protein
C4K17_RS30335	COG1872	DUF167
C4K17_RS30340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K17_RS30345	COG2813	Specifically methylates the guanine in position
C4K17_RS30345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K17_RS30355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4K17_RS30360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4K17_RS30370	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C4K17_RS30375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4K17_RS30380	COG2022	thiamine diphosphate biosynthetic process
C4K17_RS30390	COG2363	Small membrane protein
C4K17_RS30395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K17_RS30405	COG2177	Part of the ABC transporter FtsEX involved in
C4K17_RS30410	COG2884	Cell division ATP-binding protein ftsE
C4K17_RS30415	COG0552	protein localization to endoplasmic reticulum
C4K17_RS30420	COG0612	Peptidase, M16
C4K17_RS30425	COG0612	Peptidase, M16
C4K17_RS30430	COG0742	ribosomal rna small subunit methyltransferase
C4K17_RS30465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K17_RS30470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4K17_RS30475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4K17_RS30480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4K17_RS30490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K17_RS30500	COG0129	dihydroxy-acid dehydratase activity
C4K17_RS30525	COG1823	symporter activity
C4K17_RS30540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K17_RS30555	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K17_RS30560	COG1178	ABC-type Fe3 transport system permease component
C4K17_RS30565	COG3842	ATPase activity
C4K17_RS30570	COG0583	DNA-binding transcription factor activity
C4K17_RS30580	COG0789	Transcriptional regulator
C4K17_RS30585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4K17_RS30590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4K17_RS30595	COG0730	response to heat
C4K17_RS30605	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C4K17_RS30610	COG0494	nUDIX hydrolase
C4K17_RS30625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K17_RS30630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4K17_RS30635	COG2234	aminopeptidase activity
C4K17_RS30640	COG3204	pilus organization
C4K17_RS30645	COG3204	pilus organization
C4K17_RS30650	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K17_RS30655	COG0277	FAD linked oxidase domain protein
C4K17_RS30660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K17_RS30670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS30675	COG1683	Conserved Protein
C4K17_RS30705	COG1177	transmembrane transport
C4K17_RS30710	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K17_RS30715	COG3842	ATPase activity
C4K17_RS30735	COG0174	glutamine synthetase
C4K17_RS30740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K17_RS30745	COG0174	glutamine synthetase
C4K17_RS30760	COG1116	anion transmembrane transporter activity
C4K17_RS30765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K17_RS30770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K17_RS30775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K17_RS30780	COG0431	NADPH-dependent FMN reductase
C4K17_RS30785	COG0450	alkyl hydroperoxide reductase
C4K17_RS30795	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4K17_RS30795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K17_RS30800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K17_RS30810	COG1522	sequence-specific DNA binding
C4K17_RS30820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4K17_RS30830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K17_RS30830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K17_RS30835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K17_RS30850	COG0509	glycine decarboxylation via glycine cleavage system
C4K17_RS30855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K17_RS30860	COG1178	ABC-type Fe3 transport system permease component
C4K17_RS30870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K17_RS30875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K17_RS30880	COG0006	proline dipeptidase activity
C4K17_RS30885	COG3079	Belongs to the UPF0149 family
C4K17_RS30905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4K17_RS30915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K17_RS30920	COG0842	Transport permease protein
C4K17_RS30920	COG1129	ABC transporter
C4K17_RS30925	COG0842	Transport permease protein
C4K17_RS30935	COG0604	alcohol dehydrogenase
C4K17_RS30940	COG2271	Major facilitator Superfamily
C4K17_RS30955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4K17_RS30970	COG2186	Transcriptional regulator
C4K17_RS30975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS30980	COG0765	amino acid transport
C4K17_RS30985	COG0765	amino acid transport
C4K17_RS30990	COG1126	abc transporter atp-binding protein
C4K17_RS30995	COG0248	Ppx GppA phosphatase
C4K17_RS31000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4K17_RS31010	COG0586	Pfam SNARE associated Golgi protein
C4K17_RS31020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4K17_RS31025	COG1671	Belongs to the UPF0178 family
C4K17_RS31030	COG0672	)-iron permease
C4K17_RS31035	COG1280	lysine exporter protein (LysE YggA)
C4K17_RS31045	COG0488	(ABC) transporter
C4K17_RS31070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K17_RS31090	COG0181	hydroxymethylbilane synthase activity
C4K17_RS31100	COG0165	Argininosuccinate lyase
C4K17_RS31105	COG0625	glutathione transferase activity
C4K17_RS31120	COG3072	Adenylate cyclase
C4K17_RS31125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K17_RS31135	COG1965	Belongs to the frataxin family
C4K17_RS31145	COG0019	diaminopimelate decarboxylase activity
C4K17_RS31150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K17_RS31160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K17_RS31165	COG1011	Hydrolase
C4K17_RS31175	COG0432	Pfam Uncharacterised protein family UPF0047
C4K17_RS31180	COG0004	ammonium transporteR
C4K17_RS31185	COG0347	Belongs to the P(II) protein family
C4K17_RS31200	COG0529	Catalyzes the synthesis of activated sulfate
C4K17_RS31210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K17_RS31215	COG0574	Belongs to the PEP-utilizing enzyme family
C4K17_RS31215	COG3848	Pyruvate phosphate dikinase
C4K17_RS31220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K17_RS31225	COG1213	nucleotidyl transferase
C4K17_RS31230	COG0606	chelatase, subunit chli
C4K17_RS31260	COG0583	DNA-binding transcription factor activity
C4K17_RS31265	COG0534	Mate efflux family protein
C4K17_RS31280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K17_RS31285	COG0427	acetyl-CoA hydrolase
C4K17_RS31300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4K17_RS31305	COG0251	oxidation-reduction process
C4K17_RS31310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS31325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K17_RS31335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K17_RS31340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K17_RS31350	COG1012	belongs to the aldehyde dehydrogenase family
C4K17_RS31360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4K17_RS31365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4K17_RS31370	COG0747	negative chemotaxis
C4K17_RS31375	COG2003	Belongs to the UPF0758 family
C4K17_RS31380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4K17_RS31385	COG0756	dUTP diphosphatase activity
C4K17_RS31395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K17_RS31400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K17_RS31405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4K17_RS31410	COG0708	Exodeoxyribonuclease III
C4K17_RS31420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4K17_RS31425	COG1561	YicC-like family, N-terminal region
C4K17_RS31430	COG0194	GDP metabolic process
C4K17_RS31435	COG1758	RNA polymerase activity
C4K17_RS31440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K17_RS31455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K17_RS31465	COG0848	biopolymer transport protein
C4K17_RS31475	COG0583	DNA-binding transcription factor activity
C4K17_RS31480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4K17_RS31535	COG0515	serine threonine protein kinase
C4K17_RS31660	COG3161	chorismate lyase activity
C4K17_RS31665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4K17_RS31685	COG1253	flavin adenine dinucleotide binding
C4K17_RS31690	COG0739	heme binding
C4K17_RS31710	COG0704	Plays a role in the regulation of phosphate uptake
C4K17_RS31715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4K17_RS31720	COG0573	inorganic phosphate transmembrane transporter activity
C4K17_RS31735	COG0477	Major facilitator Superfamily
C4K17_RS31740	COG1607	acyl-coa hydrolase
C4K17_RS31770	COG0583	DNA-binding transcription factor activity
C4K17_RS31775	COG1027	Aspartate ammonia-lyase
C4K17_RS31785	COG1115	amino acid carrier protein
C4K17_RS31790	COG0252	asparaginase activity
C4K17_RS31845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K17_RS31850	COG0765	amino acid transport
C4K17_RS31865	COG5016	pyruvate
C4K17_RS31865	COG0511	ligase activity, forming carbon-carbon bonds
C4K17_RS31870	COG0439	Biotin carboxylase
C4K17_RS31875	COG0583	DNA-binding transcription factor activity
C4K17_RS31900	COG0210	DNA helicase
C4K17_RS31920	COG4651	solute:proton antiporter activity
C4K17_RS31920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K17_RS31925	COG1607	acyl-coa hydrolase
C4K17_RS31930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4K17_RS31940	COG0523	cobalamin synthesis protein
C4K17_RS31965	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K17_RS31970	COG1469	GTP cyclohydrolase I activity
C4K17_RS31975	COG1121	(ABC) transporter
C4K17_RS31985	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4K17_RS31990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K17_RS32000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K17_RS32005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K17_RS32015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K17_RS32020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4K17_RS32045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4K17_RS32050	COG2267	carboxylic ester hydrolase activity
C4K17_RS32055	COG0671	phosphoesterase, PA-phosphatase related
C4K17_RS32055	COG2453	phosphatase
C4K17_RS32070	COG4589	Belongs to the CDS family
C4K17_RS32075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K17_RS32085	COG1280	lysine exporter protein (LysE YggA)
C4K17_RS32090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K17_RS32095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K17_RS32095	COG2755	lipolytic protein G-D-S-L family
C4K17_RS32100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K17_RS32160	COG0625	glutathione transferase activity
C4K17_RS32165	COG0583	DNA-binding transcription factor activity
C4K17_RS32170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K17_RS32185	COG0494	nUDIX hydrolase
C4K17_RS32190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K17_RS32205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K17_RS32210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K17_RS32215	COG0494	nUDIX hydrolase
C4K17_RS32230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K17_RS32235	COG1349	DNA-binding transcription factor activity
C4K17_RS32240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K17_RS32245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4K17_RS32250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4K17_RS32255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4K17_RS32260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4K17_RS32265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4K17_RS32270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4K17_RS32280	COG0356	it plays a direct role in the translocation of protons across the membrane
C4K17_RS32285	COG3312	ion transport
C4K17_RS32290	COG1475	DNA binding
C4K17_RS32295	COG1192	Involved in chromosome partitioning
C4K17_RS32300	COG0357	Ribosomal RNA small subunit methyltransferase G
C4K17_RS32305	COG0445	tRNA wobble uridine modification
C4K17_RS32310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K17_RS32315	COG0706	membrane insertase activity
C4K17_RS32320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4K17_RS32325	COG0594	ribonuclease P activity
C4K17_RS32330	COG0230	Belongs to the bacterial ribosomal protein bL34 family