locus-tag	class	description
C4K16_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K16_RS00010	COG0592	DNA-directed DNA polymerase activity
C4K16_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K16_RS00020	COG0187	DNA topoisomerase II activity
C4K16_RS00035	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS00040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4K16_RS00070	COG5002	protein histidine kinase activity
C4K16_RS00080	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4K16_RS00085	COG0751	glycine-tRNA ligase activity
C4K16_RS00090	COG0752	glycyl-tRNA synthetase alpha subunit
C4K16_RS00095	COG2818	Glycosylase
C4K16_RS00115	COG0569	domain protein
C4K16_RS00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4K16_RS00125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS00130	COG0242	peptide deformylase activity
C4K16_RS00140	COG0758	DNA mediated transformation
C4K16_RS00145	COG0009	L-threonylcarbamoyladenylate synthase
C4K16_RS00155	COG0408	coproporphyrinogen oxidase activity
C4K16_RS00160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K16_RS00175	COG3119	arylsulfatase activity
C4K16_RS00200	COG0159	tryptophan synthase activity
C4K16_RS00205	COG0133	tryptophan synthase activity
C4K16_RS00220	COG3360	Dodecin
C4K16_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS00235	COG1764	response to oxidative stress
C4K16_RS00265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4K16_RS00270	COG0339	signal peptide processing
C4K16_RS00275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4K16_RS00310	COG0659	secondary active sulfate transmembrane transporter activity
C4K16_RS00320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K16_RS00320	COG1565	acr, cog1565
C4K16_RS00325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K16_RS00330	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4K16_RS00360	COG0109	protoheme IX farnesyltransferase activity
C4K16_RS00375	COG2011	ABC-type metal ion transport system permease component
C4K16_RS00380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K16_RS00395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K16_RS00400	COG1121	(ABC) transporter
C4K16_RS00405	COG0735	belongs to the Fur family
C4K16_RS00410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4K16_RS00430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4K16_RS00435	COG3245	cytochrome
C4K16_RS00445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K16_RS00460	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K16_RS00465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K16_RS00470	COG5002	protein histidine kinase activity
C4K16_RS00475	COG2204	response regulator
C4K16_RS00485	COG5487	UPF0391 membrane protein
C4K16_RS00495	COG1301	dicarboxylic acid transport
C4K16_RS00500	COG0700	Nucleoside recognition
C4K16_RS00515	COG1127	ABC transporter
C4K16_RS00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K16_RS00530	COG0612	Peptidase, M16
C4K16_RS00535	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K16_RS00540	COG0861	Integral membrane protein TerC family
C4K16_RS00545	COG2851	Citrate transporter
C4K16_RS00585	COG0427	acetyl-CoA hydrolase
C4K16_RS00605	COG0583	DNA-binding transcription factor activity
C4K16_RS00610	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS00665	COG3712	iron ion homeostasis
C4K16_RS00670	COG1595	DNA-templated transcription, initiation
C4K16_RS00675	COG0840	transmembrane signaling receptor activity
C4K16_RS00685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K16_RS00705	COG1802	Transcriptional regulator
C4K16_RS00715	COG3300	MHYT domain
C4K16_RS00715	COG5001	Diguanylate cyclase
C4K16_RS00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS00750	COG2175	clavaminate synthase activity
C4K16_RS00760	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K16_RS00765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS00780	COG2814	Major facilitator Superfamily
C4K16_RS00855	COG0529	Catalyzes the synthesis of activated sulfate
C4K16_RS00870	COG0330	HflC and HflK could
C4K16_RS00895	COG2026	Addiction module toxin, RelE StbE family
C4K16_RS00905	COG1289	transmembrane transporter activity
C4K16_RS00915	COG1566	PFAM secretion protein HlyD family protein
C4K16_RS00930	COG5339	Protein conserved in bacteria
C4K16_RS00935	COG0457	Tetratricopeptide repeat
C4K16_RS00940	COG0726	polysaccharide deacetylase
C4K16_RS00940	COG1649	PFAM Uncharacterised BCR, COG1649
C4K16_RS00945	COG1215	transferase activity, transferring glycosyl groups
C4K16_RS00955	COG1881	PFAM PEBP family protein
C4K16_RS00960	COG2304	oxidoreductase activity
C4K16_RS00965	COG1595	DNA-templated transcription, initiation
C4K16_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS01040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K16_RS01045	COG0745	RESPONSE REGULATOR receiver
C4K16_RS01050	COG2199	diguanylate cyclase activity
C4K16_RS01070	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4K16_RS01080	COG4208	sulfate ABC transporter
C4K16_RS01085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4K16_RS01120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS01125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS01150	COG4771	TonB-dependent receptor
C4K16_RS01245	COG2807	transmembrane transport
C4K16_RS01250	COG0590	tRNA wobble adenosine to inosine editing
C4K16_RS01260	COG0583	DNA-binding transcription factor activity
C4K16_RS01295	COG0765	amino acid transport
C4K16_RS01300	COG0765	amino acid transport
C4K16_RS01305	COG1126	abc transporter atp-binding protein
C4K16_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS01315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K16_RS01340	COG2011	ABC-type metal ion transport system permease component
C4K16_RS01345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K16_RS01370	COG1126	abc transporter atp-binding protein
C4K16_RS01375	COG0765	amino acid transport
C4K16_RS01380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS01385	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4K16_RS01390	COG1045	serine acetyltransferase
C4K16_RS01395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K16_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS01425	COG0583	DNA-binding transcription factor activity
C4K16_RS01440	COG1609	Transcriptional regulator
C4K16_RS01455	COG0667	Aldo Keto reductase
C4K16_RS01460	COG1487	ribonuclease activity
C4K16_RS01470	COG2175	clavaminate synthase activity
C4K16_RS01475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS01480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K16_RS01485	COG4521	taurine ABC transporter
C4K16_RS01490	COG2918	glutathione biosynthetic process
C4K16_RS01500	COG2183	response to ionizing radiation
C4K16_RS01510	COG2205	protein histidine kinase activity
C4K16_RS01515	COG0189	ligase activity
C4K16_RS01520	COG0189	ligase activity
C4K16_RS01520	COG4067	protein conserved in archaea
C4K16_RS01525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4K16_RS01535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4K16_RS01540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4K16_RS01580	COG0514	ATP-dependent DNA helicase (RecQ)
C4K16_RS01585	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS01585	COG1024	Enoyl-CoA hydratase
C4K16_RS01590	COG0824	Thioesterase
C4K16_RS01600	COG0243	molybdopterin cofactor binding
C4K16_RS01605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4K16_RS01615	COG1652	LysM domain
C4K16_RS01620	COG1011	Hydrolase
C4K16_RS01625	COG0494	nUDIX hydrolase
C4K16_RS01650	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4K16_RS01660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4K16_RS01670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K16_RS01680	COG2957	Belongs to the agmatine deiminase family
C4K16_RS01715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K16_RS01720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K16_RS01730	COG1845	cytochrome c oxidase, subunit III
C4K16_RS01750	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4K16_RS01790	COG0529	Catalyzes the synthesis of activated sulfate
C4K16_RS01830	COG4215	(ABC) transporter
C4K16_RS01870	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4K16_RS01875	COG1194	a g-specific adenine glycosylase
C4K16_RS01890	COG2223	nitrite transmembrane transporter activity
C4K16_RS01895	COG0131	Imidazoleglycerol-phosphate dehydratase
C4K16_RS01900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K16_RS01910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4K16_RS01915	COG0107	imidazoleglycerol-phosphate synthase activity
C4K16_RS01925	COG2861	carbohydrate metabolic process
C4K16_RS01930	COG0793	Belongs to the peptidase S41A family
C4K16_RS01935	COG4942	peptidase
C4K16_RS01940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4K16_RS01955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4K16_RS01975	COG3852	Histidine kinase
C4K16_RS01980	COG0477	Major facilitator Superfamily
C4K16_RS01985	COG0583	DNA-binding transcription factor activity
C4K16_RS01990	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS01995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K16_RS02000	COG1024	Enoyl-CoA hydratase
C4K16_RS02005	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS02010	COG0183	Belongs to the thiolase family
C4K16_RS02045	COG0301	tRNA thio-modification
C4K16_RS02045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K16_RS02050	COG1217	gtp-binding protein TYPA
C4K16_RS02060	COG0058	SHG alpha-glucan phosphorylase activity
C4K16_RS02065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4K16_RS02100	COG0402	S-adenosylhomocysteine deaminase activity
C4K16_RS02105	COG2188	Transcriptional regulator
C4K16_RS02115	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4K16_RS02120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K16_RS02130	COG4176	ABC-type proline glycine betaine transport system permease component
C4K16_RS02135	COG0517	IMP dehydrogenase activity
C4K16_RS02135	COG4175	Glycine betaine
C4K16_RS02140	COG2986	histidine ammonia-lyase
C4K16_RS02145	COG2986	histidine ammonia-lyase
C4K16_RS02155	COG1228	amidohydrolase
C4K16_RS02165	COG0596	Alpha beta hydrolase
C4K16_RS02170	COG1490	D-aminoacyl-tRNA deacylase activity
C4K16_RS02175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K16_RS02180	COG2943	transferase activity, transferring hexosyl groups
C4K16_RS02185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS02190	COG0765	amino acid transport
C4K16_RS02195	COG1126	abc transporter atp-binding protein
C4K16_RS02200	COG0840	transmembrane signaling receptor activity
C4K16_RS02215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K16_RS02220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K16_RS02225	COG0140	phosphoribosyl-ATP diphosphatase activity
C4K16_RS02230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K16_RS02235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K16_RS02245	COG2226	methyltransferase
C4K16_RS02290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4K16_RS02295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4K16_RS02305	COG0018	arginyl-trna synthetase
C4K16_RS02310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4K16_RS02315	COG0254	rRNA binding
C4K16_RS02325	COG0281	malic enzyme
C4K16_RS02360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K16_RS02365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K16_RS02380	COG0069	glutamate synthase activity
C4K16_RS02380	COG0067	glutamate synthase
C4K16_RS02380	COG0070	glutamate synthase
C4K16_RS02385	COG0493	'glutamate synthase
C4K16_RS02390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4K16_RS02395	COG3111	PFAM Bacterial OB fold (BOF) protein
C4K16_RS02400	COG2814	Major facilitator Superfamily
C4K16_RS02405	COG0583	DNA-binding transcription factor activity
C4K16_RS02420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K16_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS02435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K16_RS02445	COG2226	methyltransferase
C4K16_RS02475	COG2986	histidine ammonia-lyase
C4K16_RS02500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K16_RS02520	COG1192	Involved in chromosome partitioning
C4K16_RS02525	COG3118	belongs to the thioredoxin family
C4K16_RS02530	COG4680	protein conserved in bacteria
C4K16_RS02540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K16_RS02545	COG1196	nuclear chromosome segregation
C4K16_RS02545	COG3264	Mechanosensitive ion channel
C4K16_RS02550	COG3263	regulation of cellular component size
C4K16_RS02570	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS02575	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K16_RS02575	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K16_RS02575	COG0506	proline dehydrogenase activity
C4K16_RS02580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K16_RS02585	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4K16_RS02590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K16_RS02610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4K16_RS02615	COG0859	PFAM glycosyl transferase family 9
C4K16_RS02620	COG0859	PFAM glycosyl transferase family 9
C4K16_RS02625	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS02650	COG2192	nodulation
C4K16_RS02655	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS02680	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS02695	COG1132	(ABC) transporter
C4K16_RS02715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4K16_RS02715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4K16_RS02725	COG0667	Aldo Keto reductase
C4K16_RS02745	COG1519	Transferase
C4K16_RS02750	COG1538	Outer membrane efflux protein
C4K16_RS02755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4K16_RS02770	COG0494	nUDIX hydrolase
C4K16_RS02780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4K16_RS02785	COG3150	esterase
C4K16_RS02820	COG0560	Phosphoserine phosphatase
C4K16_RS02820	COG3830	Belongs to the UPF0237 family
C4K16_RS02825	COG0688	phosphatidylethanolamine metabolic process
C4K16_RS02850	COG1162	GTPase activity
C4K16_RS02855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4K16_RS02860	COG2860	membrane
C4K16_RS02870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4K16_RS02870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4K16_RS02875	COG0802	atpase or kinase
C4K16_RS02880	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K16_RS02885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K16_RS02890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4K16_RS02895	COG1923	regulation of RNA biosynthetic process
C4K16_RS02900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4K16_RS02905	COG0330	HflC and HflK could
C4K16_RS02910	COG0330	HflC and HflK could
C4K16_RS02915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4K16_RS02920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4K16_RS02925	COG0840	transmembrane signaling receptor activity
C4K16_RS02930	COG1178	ABC-type Fe3 transport system permease component
C4K16_RS02935	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K16_RS02950	COG0557	exoribonuclease II activity
C4K16_RS02955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4K16_RS02960	COG0360	Binds together with S18 to 16S ribosomal RNA
C4K16_RS02965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4K16_RS02975	COG0359	binds to the 23S rRNA
C4K16_RS02980	COG0305	Participates in initiation and elongation during chromosome replication
C4K16_RS02985	COG1032	radical SAM domain protein
C4K16_RS03000	COG2307	Protein conserved in bacteria
C4K16_RS03000	COG2308	Evidence 4 Homologs of previously reported genes of
C4K16_RS03035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4K16_RS03040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4K16_RS03045	COG0583	DNA-binding transcription factor activity
C4K16_RS03050	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS03055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS03065	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4K16_RS03090	COG4221	oxidoreductase activity
C4K16_RS03110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4K16_RS03115	COG0830	nickel cation binding
C4K16_RS03120	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4K16_RS03135	COG2982	Protein involved in outer membrane biogenesis
C4K16_RS03140	COG0583	DNA-binding transcription factor activity
C4K16_RS03145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K16_RS03155	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4K16_RS03160	COG0697	spore germination
C4K16_RS03165	COG2207	Transcriptional regulator
C4K16_RS03180	COG0443	Heat shock 70 kDa protein
C4K16_RS03185	COG0484	heat shock protein binding
C4K16_RS03190	COG0789	Transcriptional regulator
C4K16_RS03200	COG0804	urea catabolic process
C4K16_RS03205	COG0832	Belongs to the urease beta subunit family
C4K16_RS03220	COG0831	urea catabolic process
C4K16_RS03225	COG0829	nickel cation binding
C4K16_RS03235	COG0411	ABC transporter
C4K16_RS03250	COG0683	leucine binding
C4K16_RS03255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K16_RS03265	COG1120	ATPase activity
C4K16_RS03315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4K16_RS03325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K16_RS03350	COG2095	MarC family integral membrane protein
C4K16_RS03360	COG0151	Belongs to the GarS family
C4K16_RS03365	COG0138	bifunctional purine biosynthesis protein purh
C4K16_RS03375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K16_RS03385	COG2264	protein methyltransferase activity
C4K16_RS03400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K16_RS03430	COG0023	Translation Initiation Factor
C4K16_RS03435	COG1166	arginine decarboxylase activity
C4K16_RS03440	COG0534	Mate efflux family protein
C4K16_RS03445	COG2373	Large extracellular alpha-helical protein
C4K16_RS03455	COG4953	penicillin-binding protein 1C
C4K16_RS03465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K16_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS03575	COG0840	transmembrane signaling receptor activity
C4K16_RS03590	COG2217	Heavy metal translocating P-type atpase
C4K16_RS03620	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4K16_RS03625	COG0583	DNA-binding transcription factor activity
C4K16_RS03630	COG0477	Major facilitator Superfamily
C4K16_RS03635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4K16_RS03650	COG0387	Pfam Sodium calcium exchanger
C4K16_RS03685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K16_RS03705	COG0811	peptide transport
C4K16_RS03710	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4K16_RS03715	COG4603	Belongs to the binding-protein-dependent transport system permease family
C4K16_RS03720	COG3845	ABC transporter
C4K16_RS03730	COG1309	transcriptional regulator
C4K16_RS03735	COG2233	PERMEase
C4K16_RS03785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4K16_RS03790	COG1074	ATP-dependent DNA helicase activity
C4K16_RS03795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K16_RS03800	COG1126	abc transporter atp-binding protein
C4K16_RS03805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS03825	COG2199	diguanylate cyclase activity
C4K16_RS03875	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4K16_RS03880	COG3483	tryptophan 2,3-dioxygenase activity
C4K16_RS03885	COG1113	amino acid transport
C4K16_RS03890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K16_RS03890	COG0543	2 iron, 2 sulfur cluster binding
C4K16_RS03895	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4K16_RS03900	COG4638	Rieske (2fe-2S)
C4K16_RS03910	COG1522	sequence-specific DNA binding
C4K16_RS03920	COG1113	amino acid transport
C4K16_RS03925	COG0583	DNA-binding transcription factor activity
C4K16_RS03940	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K16_RS03945	COG0583	DNA-binding transcription factor activity
C4K16_RS03960	COG2610	gluconate transmembrane transporter activity
C4K16_RS03970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4K16_RS03995	COG0840	transmembrane signaling receptor activity
C4K16_RS04035	COG1309	transcriptional regulator
C4K16_RS04060	COG0583	DNA-binding transcription factor activity
C4K16_RS04095	COG0247	lactate metabolic process
C4K16_RS04100	COG1620	l-lactate permease
C4K16_RS04110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4K16_RS04115	COG0733	neurotransmitter:sodium symporter activity
C4K16_RS04125	COG2914	Belongs to the UPF0125 (RnfH) family
C4K16_RS04130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4K16_RS04140	COG0497	DNA recombination
C4K16_RS04145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4K16_RS04150	COG0443	Heat shock 70 kDa protein
C4K16_RS04155	COG0484	heat shock protein binding
C4K16_RS04160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4K16_RS04165	COG0505	Belongs to the CarA family
C4K16_RS04170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4K16_RS04175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K16_RS04190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4K16_RS04200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4K16_RS04205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K16_RS04210	COG0149	triose-phosphate isomerase activity
C4K16_RS04215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4K16_RS04235	COG0195	Participates in both transcription termination and antitermination
C4K16_RS04240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4K16_RS04245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4K16_RS04250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4K16_RS04255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4K16_RS04260	COG1185	polyribonucleotide nucleotidyltransferase activity
C4K16_RS04290	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K16_RS04305	COG0084	hydrolase, TatD family'
C4K16_RS04310	COG1609	Transcriptional regulator
C4K16_RS04315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K16_RS04315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K16_RS04320	COG1105	Belongs to the carbohydrate kinase PfkB family
C4K16_RS04325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4K16_RS04325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K16_RS04325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K16_RS04340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4K16_RS04345	COG4774	siderophore transport
C4K16_RS04350	COG3128	pkhd-type hydroxylase
C4K16_RS04360	COG0019	diaminopimelate decarboxylase activity
C4K16_RS04390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4K16_RS04400	COG4608	Belongs to the ABC transporter superfamily
C4K16_RS04405	COG0444	Belongs to the ABC transporter superfamily
C4K16_RS04410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K16_RS04415	COG0601	transmembrane transport
C4K16_RS04420	COG0747	negative chemotaxis
C4K16_RS04430	COG0747	negative chemotaxis
C4K16_RS04435	COG0747	negative chemotaxis
C4K16_RS04445	COG1917	Cupin 2, conserved barrel domain protein
C4K16_RS04445	COG1396	sequence-specific DNA binding
C4K16_RS04460	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4K16_RS04465	COG4178	(ABC) transporter
C4K16_RS04470	COG2186	Transcriptional regulator
C4K16_RS04485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K16_RS04495	COG2271	Major facilitator Superfamily
C4K16_RS04500	COG2721	sulfolactate sulfo-lyase activity
C4K16_RS04510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K16_RS04520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K16_RS04525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K16_RS04530	COG0154	amidase activity
C4K16_RS04535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K16_RS04540	COG1077	Cell shape determining protein MreB Mrl
C4K16_RS04545	COG1792	Involved in formation and maintenance of cell shape
C4K16_RS04555	COG0424	maF-like protein
C4K16_RS04560	COG1530	ribonuclease E activity
C4K16_RS04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K16_RS04575	COG0312	modulator of DNA gyrase
C4K16_RS04580	COG3028	Belongs to the UPF0307 family
C4K16_RS04585	COG0312	modulator of DNA gyrase
C4K16_RS04620	COG1660	Displays ATPase and GTPase activities
C4K16_RS04635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4K16_RS04640	COG1137	ATPase activity
C4K16_RS04645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4K16_RS04655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4K16_RS04665	COG1127	ABC transporter
C4K16_RS04670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K16_RS04675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4K16_RS04695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4K16_RS04700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4K16_RS04705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K16_RS04710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K16_RS04715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K16_RS04730	COG0175	sulfate reduction
C4K16_RS04740	COG0204	Acyl-transferase
C4K16_RS04745	COG0857	belongs to the CobB CobQ family
C4K16_RS04745	COG0280	phosphate acetyltransferase
C4K16_RS04760	COG0386	Belongs to the glutathione peroxidase family
C4K16_RS04775	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4K16_RS04785	COG0492	ferredoxin-NADP+ reductase activity
C4K16_RS04800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K16_RS04805	COG0302	gtp cyclohydrolase
C4K16_RS04820	COG0789	Transcriptional regulator
C4K16_RS04830	COG1366	Belongs to the anti-sigma-factor antagonist family
C4K16_RS04840	COG0583	DNA-binding transcription factor activity
C4K16_RS04845	COG1380	Effector of murein hydrolase LrgA
C4K16_RS04850	COG1346	cytolysis
C4K16_RS04860	COG0596	Alpha beta hydrolase
C4K16_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS04885	COG2909	trisaccharide binding
C4K16_RS04895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4K16_RS04900	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K16_RS04920	COG2226	methyltransferase
C4K16_RS04965	COG0814	amino acid
C4K16_RS04970	COG1760	l-serine dehydratase
C4K16_RS04975	COG0583	DNA-binding transcription factor activity
C4K16_RS04995	COG4772	TonB-dependent receptor
C4K16_RS05000	COG3712	iron ion homeostasis
C4K16_RS05005	COG1595	DNA-templated transcription, initiation
C4K16_RS05025	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K16_RS05035	COG0697	spore germination
C4K16_RS05045	COG0583	DNA-binding transcription factor activity
C4K16_RS05065	COG1566	PFAM secretion protein HlyD family protein
C4K16_RS05085	COG0300	oxidoreductase activity
C4K16_RS05125	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4K16_RS05125	COG0662	Cupin 2, conserved barrel domain protein
C4K16_RS05140	COG1696	Membrane protein involved in D-alanine export
C4K16_RS05155	COG3420	alginic acid biosynthetic process
C4K16_RS05165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4K16_RS05170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS05175	COG1215	transferase activity, transferring glycosyl groups
C4K16_RS05185	COG3022	response to hydroperoxide
C4K16_RS05195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4K16_RS05200	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K16_RS05205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K16_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS05235	COG0513	Belongs to the DEAD box helicase family
C4K16_RS05245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS05250	COG4597	amino acid ABC transporter
C4K16_RS05255	COG0765	amino acid transport
C4K16_RS05260	COG1126	abc transporter atp-binding protein
C4K16_RS05265	COG2944	sequence-specific DNA binding
C4K16_RS05275	COG2186	Transcriptional regulator
C4K16_RS05280	COG2807	transmembrane transport
C4K16_RS05290	COG2827	Endonuclease containing a URI domain
C4K16_RS05310	COG3081	Nucleoid-associated protein
C4K16_RS05320	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4K16_RS05325	COG0525	valine-tRNA ligase activity
C4K16_RS05340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4K16_RS05345	COG0795	lipopolysaccharide-transporting ATPase activity
C4K16_RS05350	COG0795	lipopolysaccharide-transporting ATPase activity
C4K16_RS05355	COG0481	GTPase activity
C4K16_RS05360	COG0681	Belongs to the peptidase S26 family
C4K16_RS05370	COG0571	ribonuclease III activity
C4K16_RS05375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4K16_RS05380	COG1381	Involved in DNA repair and RecF pathway recombination
C4K16_RS05385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4K16_RS05390	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K16_RS05395	COG0047	phosphoribosylformylglycinamidine synthase activity
C4K16_RS05395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4K16_RS05405	COG1263	PTS System
C4K16_RS05405	COG2190	(PTS) system
C4K16_RS05405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K16_RS05410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K16_RS05410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K16_RS05415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K16_RS05420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4K16_RS05425	COG2188	Transcriptional regulator
C4K16_RS05440	COG0494	nUDIX hydrolase
C4K16_RS05460	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4K16_RS05465	COG0477	Major facilitator Superfamily
C4K16_RS05470	COG4536	flavin adenine dinucleotide binding
C4K16_RS05480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4K16_RS05485	COG0228	four-way junction DNA binding
C4K16_RS05490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4K16_RS05495	COG0336	Belongs to the RNA methyltransferase TrmD family
C4K16_RS05500	COG0335	large ribosomal subunit rRNA binding
C4K16_RS05505	COG1607	acyl-coa hydrolase
C4K16_RS05515	COG4974	Belongs to the 'phage' integrase family
C4K16_RS05535	COG2205	protein histidine kinase activity
C4K16_RS05535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS05545	COG2197	response regulator
C4K16_RS05565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K16_RS05580	COG1902	pentaerythritol trinitrate reductase activity
C4K16_RS05585	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K16_RS05615	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS05620	COG1177	transmembrane transport
C4K16_RS05625	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K16_RS05630	COG3842	ATPase activity
C4K16_RS05635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K16_RS05640	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS05645	COG0583	DNA-binding transcription factor activity
C4K16_RS05665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K16_RS05665	COG0457	Tetratricopeptide repeat
C4K16_RS05680	COG2201	protein-glutamate methylesterase activity
C4K16_RS05685	COG5001	Diguanylate cyclase
C4K16_RS05685	COG4251	negative regulation of phosphorylation
C4K16_RS05685	COG3706	GGDEF domain
C4K16_RS05685	COG2203	Gaf domain
C4K16_RS05695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4K16_RS05715	COG1073	alpha beta
C4K16_RS05740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4K16_RS05750	COG0563	adenylate kinase activity
C4K16_RS05755	COG1214	PFAM Peptidase M22, glycoprotease
C4K16_RS05765	COG1801	Protein of unknown function DUF72
C4K16_RS05780	COG0742	ribosomal rna small subunit methyltransferase
C4K16_RS05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS05810	COG2937	Belongs to the GPAT DAPAT family
C4K16_RS05825	COG2226	methyltransferase
C4K16_RS05830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K16_RS05840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4K16_RS05850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K16_RS05855	COG2171	N-acyltransferase activity
C4K16_RS05860	COG1393	Belongs to the ArsC family
C4K16_RS05865	COG0025	NhaP-type Na H and K H
C4K16_RS05870	COG0436	Aminotransferase
C4K16_RS05875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4K16_RS05880	COG0024	Methionine aminopeptidase
C4K16_RS05885	COG0052	Belongs to the universal ribosomal protein uS2 family
C4K16_RS05890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4K16_RS05895	COG0528	UMP kinase activity
C4K16_RS05900	COG0233	cytoplasmic translational termination
C4K16_RS05905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4K16_RS05915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4K16_RS05935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K16_RS05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K16_RS05945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K16_RS05950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K16_RS05955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4K16_RS05960	COG0587	DNA-directed DNA polymerase activity
C4K16_RS05965	COG0825	malonyl-CoA metabolic process
C4K16_RS05970	COG0037	tRNA processing
C4K16_RS05975	COG0504	CTP synthase activity
C4K16_RS05980	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4K16_RS05985	COG0148	phosphopyruvate hydratase activity
C4K16_RS05995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4K16_RS06005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4K16_RS06010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4K16_RS06015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4K16_RS06020	COG0585	pseudouridine synthase activity
C4K16_RS06025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K16_RS06030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4K16_RS06050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4K16_RS06075	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K16_RS06170	COG4386	tail sheath protein
C4K16_RS06205	COG4381	Mu-like prophage protein gp46
C4K16_RS06250	COG3179	chitinase
C4K16_RS06260	COG1546	Belongs to the CinA family
C4K16_RS06265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4K16_RS06270	COG2137	regulation of response to DNA damage stimulus
C4K16_RS06290	COG3148	PFAM DTW domain containing protein
C4K16_RS06305	COG0583	DNA-binding transcription factor activity
C4K16_RS06325	COG4807	Protein conserved in bacteria
C4K16_RS06330	COG1187	pseudouridine synthase activity
C4K16_RS06340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K16_RS06350	COG3158	transport of potassium into the cell
C4K16_RS06360	COG0392	lysyltransferase activity
C4K16_RS06360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4K16_RS06375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4K16_RS06385	COG0442	prolyl-tRNA aminoacylation
C4K16_RS06410	COG1278	Cold shock
C4K16_RS06415	COG0717	Belongs to the dCTP deaminase family
C4K16_RS06440	COG4215	(ABC) transporter
C4K16_RS06450	COG2366	antibiotic biosynthetic process
C4K16_RS06455	COG0625	glutathione transferase activity
C4K16_RS06465	COG0653	protein targeting
C4K16_RS06475	COG3012	SEC-C Motif Domain Protein
C4K16_RS06510	COG1199	ATP-dependent helicase activity
C4K16_RS06525	COG2885	chlorophyll binding
C4K16_RS06530	COG0259	pyridoxamine-phosphate oxidase activity
C4K16_RS06545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K16_RS06555	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4K16_RS06570	COG0583	DNA-binding transcription factor activity
C4K16_RS06585	COG3220	belongs to the UPF0276 family
C4K16_RS06630	COG2084	Dehydrogenase
C4K16_RS06640	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4K16_RS06645	COG2271	Major facilitator Superfamily
C4K16_RS06650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K16_RS06660	COG0306	phosphate transporter
C4K16_RS06675	COG1414	Transcriptional regulator
C4K16_RS06680	COG2814	Major facilitator Superfamily
C4K16_RS06685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K16_RS06690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4K16_RS06695	COG0183	Belongs to the thiolase family
C4K16_RS06700	COG3485	protocatechuate 3,4-dioxygenase
C4K16_RS06705	COG3485	protocatechuate 3,4-dioxygenase
C4K16_RS06710	COG0477	Major facilitator Superfamily
C4K16_RS06720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K16_RS06725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K16_RS06745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS06760	COG1902	pentaerythritol trinitrate reductase activity
C4K16_RS06765	COG2814	Major facilitator Superfamily
C4K16_RS06815	COG0154	amidase activity
C4K16_RS06840	COG1704	LemA family
C4K16_RS06845	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4K16_RS06860	COG0697	spore germination
C4K16_RS06865	COG0693	protein deglycase activity
C4K16_RS06880	COG1629	transport
C4K16_RS06890	COG1595	DNA-templated transcription, initiation
C4K16_RS06895	COG3422	double-strand break repair
C4K16_RS06900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K16_RS06905	COG0235	Class ii aldolase
C4K16_RS06910	COG1396	sequence-specific DNA binding
C4K16_RS06920	COG1454	alcohol dehydrogenase
C4K16_RS06925	COG1309	transcriptional regulator
C4K16_RS06935	COG3668	Plasmid stabilization system
C4K16_RS07010	COG3938	Belongs to the proline racemase family
C4K16_RS07015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K16_RS07020	COG0531	amino acid
C4K16_RS07030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4K16_RS07050	COG0583	DNA-binding transcription factor activity
C4K16_RS07055	COG5001	Diguanylate cyclase
C4K16_RS07065	COG3468	outer membrane autotransporter barrel domain protein
C4K16_RS07075	COG2267	carboxylic ester hydrolase activity
C4K16_RS07090	COG3706	GGDEF domain
C4K16_RS07105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4K16_RS07150	COG0354	folic acid binding
C4K16_RS07155	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4K16_RS07190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K16_RS07200	COG0425	Belongs to the sulfur carrier protein TusA family
C4K16_RS07210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4K16_RS07225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K16_RS07230	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4K16_RS07235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K16_RS07240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4K16_RS07260	COG2197	response regulator
C4K16_RS07270	COG3121	Chaperone
C4K16_RS07280	COG3121	Chaperone
C4K16_RS07285	COG2831	hemolysin activation secretion protein
C4K16_RS07290	COG3210	domain, Protein
C4K16_RS07320	COG2807	transmembrane transport
C4K16_RS07325	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4K16_RS07335	COG0583	DNA-binding transcription factor activity
C4K16_RS07345	COG2194	sulfuric ester hydrolase activity
C4K16_RS07360	COG3100	YcgL domain-containing protein
C4K16_RS07365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K16_RS07375	COG2983	Belongs to the UPF0260 family
C4K16_RS07425	COG0121	glutamine amidotransferase
C4K16_RS07435	COG0583	DNA-binding transcription factor activity
C4K16_RS07440	COG2814	Major facilitator Superfamily
C4K16_RS07445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K16_RS07450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K16_RS07455	COG1984	allophanate hydrolase subunit 2
C4K16_RS07465	COG0542	response to heat
C4K16_RS07475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K16_RS07505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4K16_RS07510	COG1643	Atp-dependent helicase
C4K16_RS07520	COG1595	DNA-templated transcription, initiation
C4K16_RS07560	COG0814	amino acid
C4K16_RS07580	COG4638	Rieske (2fe-2S)
C4K16_RS07595	COG0477	Major facilitator Superfamily
C4K16_RS07600	COG0583	DNA-binding transcription factor activity
C4K16_RS07610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4K16_RS07615	COG1132	(ABC) transporter
C4K16_RS07625	COG2267	carboxylic ester hydrolase activity
C4K16_RS07640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K16_RS07650	COG0668	transmembrane transport
C4K16_RS07655	COG0513	Belongs to the DEAD box helicase family
C4K16_RS07715	COG1953	Uracil, thiamine, allantoin
C4K16_RS07720	COG0697	spore germination
C4K16_RS07730	COG0583	DNA-binding transcription factor activity
C4K16_RS07740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K16_RS07745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K16_RS07775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS07795	COG5001	Diguanylate cyclase
C4K16_RS07795	COG3300	MHYT domain
C4K16_RS07805	COG2832	Protein of unknown function (DUF454)
C4K16_RS07830	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4K16_RS07845	COG2207	Transcriptional regulator
C4K16_RS07870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4K16_RS07890	COG0745	RESPONSE REGULATOR receiver
C4K16_RS07900	COG2350	Protein conserved in bacteria
C4K16_RS07905	COG2917	probably involved in intracellular septation
C4K16_RS07910	COG0613	PHP domain protein
C4K16_RS07915	COG0009	L-threonylcarbamoyladenylate synthase
C4K16_RS07925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4K16_RS07945	COG1113	amino acid transport
C4K16_RS07970	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4K16_RS07985	COG4786	Flagellar basal body rod
C4K16_RS07995	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4K16_RS08000	COG1706	bacterial-type flagellum-dependent cell motility
C4K16_RS08010	COG1256	bacterial-type flagellum assembly
C4K16_RS08020	COG1216	Glycosyl transferase, family 2
C4K16_RS08020	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS08025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K16_RS08035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4K16_RS08060	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS08060	COG1216	Glycosyl transferase, family 2
C4K16_RS08065	COG1086	Polysaccharide biosynthesis protein
C4K16_RS08070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K16_RS08075	COG1083	cytidylyl-transferase
C4K16_RS08085	COG2089	acid synthase
C4K16_RS08105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4K16_RS08115	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4K16_RS08145	COG1677	Flagellar hook-basal body complex protein FliE
C4K16_RS08180	COG0745	RESPONSE REGULATOR receiver
C4K16_RS08260	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4K16_RS08265	COG0643	Histidine kinase
C4K16_RS08265	COG2198	Histidine kinase
C4K16_RS08265	COG0784	Response regulator, receiver
C4K16_RS08270	COG2201	protein-glutamate methylesterase activity
C4K16_RS08275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4K16_RS08285	COG1192	Involved in chromosome partitioning
C4K16_RS08295	COG0835	chemotaxis
C4K16_RS08305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4K16_RS08315	COG4133	protoheme IX ABC transporter activity
C4K16_RS08335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4K16_RS08340	COG1138	Cytochrome C-type biogenesis protein
C4K16_RS08350	COG3088	subunit of a heme lyase
C4K16_RS08370	COG0583	DNA-binding transcription factor activity
C4K16_RS08375	COG2814	Major facilitator Superfamily
C4K16_RS08395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K16_RS08400	COG4413	Urea transporter
C4K16_RS08405	COG0469	pyruvate kinase activity
C4K16_RS08415	COG2084	Dehydrogenase
C4K16_RS08420	COG3622	Belongs to the hyi family
C4K16_RS08425	COG3960	tartronate-semialdehyde synthase activity
C4K16_RS08435	COG1309	transcriptional regulator
C4K16_RS08440	COG2354	Protein conserved in bacteria
C4K16_RS08445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS08460	COG1834	amidinotransferase
C4K16_RS08470	COG2192	nodulation
C4K16_RS08475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K16_RS08480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS08500	COG2853	Lipoprotein
C4K16_RS08520	COG2113	Glycine betaine
C4K16_RS08525	COG3162	membrane
C4K16_RS08530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K16_RS08540	COG2009	succinate dehydrogenase
C4K16_RS08545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4K16_RS08550	COG1053	succinate dehydrogenase
C4K16_RS08570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K16_RS08575	COG0045	succinate-CoA ligase (ADP-forming) activity
C4K16_RS08615	COG0326	Molecular chaperone. Has ATPase activity
C4K16_RS08625	COG0626	cystathionine gamma-synthase activity
C4K16_RS08635	COG1741	Belongs to the pirin family
C4K16_RS08660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K16_RS08665	COG5002	protein histidine kinase activity
C4K16_RS08665	COG2205	protein histidine kinase activity
C4K16_RS08665	COG0784	Response regulator, receiver
C4K16_RS08675	COG4771	TonB-dependent receptor
C4K16_RS08680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4K16_RS08690	COG2062	phosphohistidine phosphatase, SixA
C4K16_RS08695	COG1022	Amp-dependent synthetase and ligase
C4K16_RS08715	COG0625	glutathione transferase activity
C4K16_RS08725	COG0628	permease
C4K16_RS08740	COG0284	orotidine-5'-phosphate decarboxylase activity
C4K16_RS08745	COG2130	NADP-dependent
C4K16_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS08755	COG0840	transmembrane signaling receptor activity
C4K16_RS08785	COG2814	Major facilitator Superfamily
C4K16_RS08790	COG3210	domain, Protein
C4K16_RS08800	COG3121	Chaperone
C4K16_RS08815	COG2205	protein histidine kinase activity
C4K16_RS08815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS08835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K16_RS08850	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS08860	COG0625	glutathione transferase activity
C4K16_RS08865	COG1131	(ABC) transporter
C4K16_RS08870	COG0842	Transport permease protein
C4K16_RS08880	COG0658	competence protein
C4K16_RS08880	COG2333	competence protein COMEC
C4K16_RS08885	COG0811	peptide transport
C4K16_RS08890	COG0848	biopolymer transport protein
C4K16_RS08895	COG1663	tetraacyldisaccharide 4'-kinase activity
C4K16_RS08900	COG2835	tetraacyldisaccharide 4'-kinase activity
C4K16_RS08905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K16_RS08910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K16_RS08915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4K16_RS08925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K16_RS08930	COG3608	succinylglutamate desuccinylase aspartoacylase
C4K16_RS08930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4K16_RS08940	COG1530	ribonuclease E activity
C4K16_RS08950	COG0546	phosphoglycolate phosphatase activity
C4K16_RS08955	COG0616	signal peptide processing
C4K16_RS08955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K16_RS08960	COG0424	maF-like protein
C4K16_RS08970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4K16_RS08975	COG0416	fatty acid biosynthetic process
C4K16_RS08990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K16_RS08995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K16_RS09005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4K16_RS09010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4K16_RS09020	COG0084	hydrolase, TatD family'
C4K16_RS09035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K16_RS09050	COG2188	Transcriptional regulator
C4K16_RS09055	COG1397	ADP-ribosylglycohydrolase
C4K16_RS09065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K16_RS09095	COG1418	mRNA catabolic process
C4K16_RS09105	COG3734	2-keto-3-deoxy-galactonokinase
C4K16_RS09110	COG0800	Aldolase
C4K16_RS09115	COG4948	Mandelate Racemase Muconate Lactonizing
C4K16_RS09120	COG2271	Major facilitator Superfamily
C4K16_RS09125	COG1414	Transcriptional regulator
C4K16_RS09130	COG1064	alcohol dehydrogenase
C4K16_RS09135	COG2207	Transcriptional regulator
C4K16_RS09165	COG2885	chlorophyll binding
C4K16_RS09165	COG3047	cAMP biosynthetic process
C4K16_RS09170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS09205	COG0183	Belongs to the thiolase family
C4K16_RS09210	COG1024	Enoyl-CoA hydratase
C4K16_RS09210	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS09215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K16_RS09215	COG0519	Catalyzes the synthesis of GMP from XMP
C4K16_RS09220	COG0583	DNA-binding transcription factor activity
C4K16_RS09230	COG0598	Magnesium transport protein CorA
C4K16_RS09235	COG0204	Acyl-transferase
C4K16_RS09280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K16_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS09290	COG0583	DNA-binding transcription factor activity
C4K16_RS09300	COG1953	Uracil, thiamine, allantoin
C4K16_RS09310	COG0560	Phosphoserine phosphatase
C4K16_RS09330	COG4067	protein conserved in archaea
C4K16_RS09330	COG0189	ligase activity
C4K16_RS09335	COG1802	Transcriptional regulator
C4K16_RS09345	COG0372	Belongs to the citrate synthase family
C4K16_RS09360	COG2079	MmgE PrpD family protein
C4K16_RS09365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4K16_RS09380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K16_RS09395	COG0668	transmembrane transport
C4K16_RS09405	COG3047	cAMP biosynthetic process
C4K16_RS09405	COG2885	chlorophyll binding
C4K16_RS09410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K16_RS09415	COG0243	molybdopterin cofactor binding
C4K16_RS09420	COG2146	nitrite reductase [NAD(P)H] activity
C4K16_RS09425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K16_RS09430	COG2815	serine threonine protein kinase
C4K16_RS09430	COG0515	serine threonine protein kinase
C4K16_RS09435	COG2223	nitrite transmembrane transporter activity
C4K16_RS09440	COG3707	response regulator
C4K16_RS09445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS09450	COG0167	dihydroorotate dehydrogenase activity
C4K16_RS09455	COG3130	regulation of translation
C4K16_RS09460	COG0116	Belongs to the methyltransferase superfamily
C4K16_RS09460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K16_RS09470	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K16_RS09475	COG3171	Protein conserved in bacteria
C4K16_RS09480	COG3135	benzoate transporter
C4K16_RS09485	COG1802	Transcriptional regulator
C4K16_RS09490	COG0402	S-adenosylhomocysteine deaminase activity
C4K16_RS09515	COG1196	nuclear chromosome segregation
C4K16_RS09520	COG3115	cell septum assembly
C4K16_RS09525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K16_RS09580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4K16_RS09585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4K16_RS09590	COG2130	NADP-dependent
C4K16_RS09595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4K16_RS09600	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS09605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K16_RS09610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K16_RS09630	COG2217	Heavy metal translocating P-type atpase
C4K16_RS09640	COG0348	domain, Protein
C4K16_RS09655	COG2010	Cytochrome c
C4K16_RS09670	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K16_RS09675	COG2010	Cytochrome c
C4K16_RS09690	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K16_RS09700	COG0840	transmembrane signaling receptor activity
C4K16_RS09715	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4K16_RS09720	COG0425	Belongs to the sulfur carrier protein TusA family
C4K16_RS09730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K16_RS09740	COG1132	(ABC) transporter
C4K16_RS09745	COG0741	lytic transglycosylase activity
C4K16_RS09750	COG0488	(ABC) transporter
C4K16_RS09755	COG0589	response to stress
C4K16_RS09770	COG1024	Enoyl-CoA hydratase
C4K16_RS09770	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS09775	COG0183	Belongs to the thiolase family
C4K16_RS09820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K16_RS09825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K16_RS09835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4K16_RS09850	COG1477	protein flavinylation
C4K16_RS09855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K16_RS09860	COG0584	glycerophosphoryl diester phosphodiesterase
C4K16_RS09870	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K16_RS09875	COG1136	(ABC) transporter
C4K16_RS09880	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K16_RS09900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K16_RS09900	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K16_RS09915	COG2853	Lipoprotein
C4K16_RS09930	COG2204	response regulator
C4K16_RS09940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4K16_RS09945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K16_RS09950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K16_RS09955	COG0583	DNA-binding transcription factor activity
C4K16_RS09965	COG5001	Diguanylate cyclase
C4K16_RS09965	COG4251	negative regulation of phosphorylation
C4K16_RS09965	COG2203	Gaf domain
C4K16_RS09965	COG3706	GGDEF domain
C4K16_RS10020	COG0556	nucleotide-excision repair
C4K16_RS10035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K16_RS10065	COG0596	Alpha beta hydrolase
C4K16_RS10075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K16_RS10090	COG2214	Heat shock protein DnaJ domain protein
C4K16_RS10095	COG0443	Heat shock 70 kDa protein
C4K16_RS10110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4K16_RS10115	COG0066	3-isopropylmalate dehydratase activity
C4K16_RS10120	COG0473	3-isopropylmalate dehydrogenase activity
C4K16_RS10150	COG0135	phosphoribosylanthranilate isomerase activity
C4K16_RS10155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4K16_RS10160	COG0285	dihydrofolate synthase activity
C4K16_RS10165	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K16_RS10170	COG1286	toxin biosynthetic process
C4K16_RS10205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS10235	COG3397	chitin binding
C4K16_RS10240	COG3469	chitinase activity
C4K16_RS10255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K16_RS10290	COG1129	ABC transporter
C4K16_RS10295	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K16_RS10300	COG1609	Transcriptional regulator
C4K16_RS10305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K16_RS10310	COG1869	D-ribose catabolic process
C4K16_RS10335	COG1278	Cold shock
C4K16_RS10345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K16_RS10350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4K16_RS10355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4K16_RS10360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4K16_RS10365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4K16_RS10370	COG0072	phenylalanine-tRNA ligase activity
C4K16_RS10375	COG0776	regulation of translation
C4K16_RS10445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K16_RS10480	COG1309	transcriptional regulator
C4K16_RS10485	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS10495	COG3284	Transcriptional regulator
C4K16_RS10500	COG3199	ATP-NAD kinase
C4K16_RS10505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K16_RS10510	COG0022	dehydrogenase e1 component
C4K16_RS10520	COG1063	alcohol dehydrogenase
C4K16_RS10535	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS10545	COG4191	Histidine kinase
C4K16_RS10550	COG4566	intracellular signal transduction
C4K16_RS10565	COG1598	PFAM Uncharacterised protein family UPF0150
C4K16_RS10605	COG0450	alkyl hydroperoxide reductase
C4K16_RS10635	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K16_RS10640	COG3657	addiction module killer protein
C4K16_RS10645	COG5383	Protein conserved in bacteria
C4K16_RS10650	COG3706	GGDEF domain
C4K16_RS10675	COG0531	amino acid
C4K16_RS10685	COG0174	glutamine synthetase
C4K16_RS10690	COG1335	isochorismatase
C4K16_RS10700	COG0583	DNA-binding transcription factor activity
C4K16_RS10770	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4K16_RS10775	COG0247	lactate metabolic process
C4K16_RS10780	COG0277	FAD linked oxidase domain protein
C4K16_RS10785	COG0277	FAD linked oxidase domain protein
C4K16_RS10790	COG2186	Transcriptional regulator
C4K16_RS10820	COG1063	alcohol dehydrogenase
C4K16_RS10840	COG0709	Synthesizes selenophosphate from selenide and ATP
C4K16_RS10845	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4K16_RS10850	COG0701	Predicted permease
C4K16_RS10855	COG1414	Transcriptional regulator
C4K16_RS10860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS10865	COG0765	amino acid transport
C4K16_RS10870	COG1126	abc transporter atp-binding protein
C4K16_RS10875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS10885	COG0625	glutathione transferase activity
C4K16_RS10890	COG0384	phenazine biosynthesis protein PhzF
C4K16_RS10905	COG0248	Ppx GppA phosphatase
C4K16_RS10910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K16_RS10930	COG0019	diaminopimelate decarboxylase activity
C4K16_RS10945	COG0071	Belongs to the small heat shock protein (HSP20) family
C4K16_RS10950	COG0113	porphobilinogen synthase activity
C4K16_RS10980	COG4172	Belongs to the ABC transporter superfamily
C4K16_RS10985	COG4239	(ABC) transporter, permease
C4K16_RS10990	COG4174	ABC transporter (Permease)
C4K16_RS10995	COG4166	transmembrane transport
C4K16_RS11030	COG4650	regulator
C4K16_RS11040	COG1690	Belongs to the RtcB family
C4K16_RS11050	COG3541	Predicted nucleotidyltransferase
C4K16_RS11055	COG0430	RNA-3'-phosphate cyclase activity
C4K16_RS11085	COG0583	DNA-binding transcription factor activity
C4K16_RS11110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K16_RS11115	COG0583	DNA-binding transcription factor activity
C4K16_RS11120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K16_RS11130	COG3180	Ammonia monooxygenase
C4K16_RS11135	COG0583	DNA-binding transcription factor activity
C4K16_RS11140	COG0517	IMP dehydrogenase activity
C4K16_RS11160	COG1177	transmembrane transport
C4K16_RS11165	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K16_RS11170	COG3842	ATPase activity
C4K16_RS11175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K16_RS11185	COG0174	glutamine synthetase
C4K16_RS11190	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS11195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS11200	COG1917	Cupin 2, conserved barrel domain protein
C4K16_RS11200	COG1396	sequence-specific DNA binding
C4K16_RS11250	COG1595	DNA-templated transcription, initiation
C4K16_RS11255	COG3712	iron ion homeostasis
C4K16_RS11260	COG4772	TonB-dependent receptor
C4K16_RS11265	COG1944	ATP diphosphatase activity
C4K16_RS11335	COG2223	nitrite transmembrane transporter activity
C4K16_RS11355	COG0697	spore germination
C4K16_RS11360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS11370	COG0659	secondary active sulfate transmembrane transporter activity
C4K16_RS11380	COG1999	signal sequence binding
C4K16_RS11395	COG0583	DNA-binding transcription factor activity
C4K16_RS11400	COG3048	D-serine ammonia-lyase activity
C4K16_RS11405	COG2610	gluconate transmembrane transporter activity
C4K16_RS11410	COG0251	oxidation-reduction process
C4K16_RS11420	COG0688	phosphatidylethanolamine metabolic process
C4K16_RS11435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K16_RS11440	COG0477	Major facilitator Superfamily
C4K16_RS11445	COG0346	lactoylglutathione lyase activity
C4K16_RS11455	COG0826	peptidase U32
C4K16_RS11470	COG0784	Response regulator, receiver
C4K16_RS11470	COG2205	protein histidine kinase activity
C4K16_RS11485	COG2197	response regulator
C4K16_RS11495	COG1538	Outer membrane efflux protein
C4K16_RS11505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS11560	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K16_RS11570	COG1611	Belongs to the LOG family
C4K16_RS11585	COG2204	response regulator
C4K16_RS11590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4K16_RS11600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K16_RS11615	COG0494	nUDIX hydrolase
C4K16_RS11650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS11655	COG0174	glutamine synthetase
C4K16_RS11670	COG1335	isochorismatase
C4K16_RS11675	COG3224	Antibiotic biosynthesis monooxygenase
C4K16_RS11680	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K16_RS11695	COG0417	DNA replication proofreading
C4K16_RS11705	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K16_RS11720	COG0477	Major facilitator Superfamily
C4K16_RS11740	COG4319	ketosteroid isomerase
C4K16_RS11745	COG4335	DNA alkylation repair
C4K16_RS11755	COG0583	DNA-binding transcription factor activity
C4K16_RS11760	COG2828	Protein conserved in bacteria
C4K16_RS11765	COG1301	dicarboxylic acid transport
C4K16_RS11770	COG2851	Citrate transporter
C4K16_RS11785	COG1704	LemA family
C4K16_RS11790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K16_RS11815	COG1230	cation diffusion facilitator family transporter
C4K16_RS11820	COG2267	carboxylic ester hydrolase activity
C4K16_RS11830	COG2124	cytochrome p450
C4K16_RS11835	COG0640	Transcriptional regulator
C4K16_RS11850	COG2308	Evidence 4 Homologs of previously reported genes of
C4K16_RS11860	COG1305	Transglutaminase-like
C4K16_RS11865	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K16_RS11870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4K16_RS11875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K16_RS11885	COG0022	dehydrogenase e1 component
C4K16_RS11890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K16_RS11895	COG1522	sequence-specific DNA binding
C4K16_RS11905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K16_RS11935	COG1309	transcriptional regulator
C4K16_RS11945	COG0493	'glutamate synthase
C4K16_RS11955	COG1953	Uracil, thiamine, allantoin
C4K16_RS11965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS11970	COG4175	Glycine betaine
C4K16_RS11980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K16_RS11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS12005	COG4804	nuclease activity
C4K16_RS12030	COG1595	DNA-templated transcription, initiation
C4K16_RS12040	COG3177	Filamentation induced by cAMP protein fic
C4K16_RS12060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K16_RS12110	COG2391	methyltransferase activity
C4K16_RS12175	COG0745	RESPONSE REGULATOR receiver
C4K16_RS12190	COG3383	formate dehydrogenase (NAD+) activity
C4K16_RS12195	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K16_RS12200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS12235	COG3718	enzyme involved in inositol metabolism
C4K16_RS12250	COG3962	Belongs to the TPP enzyme family
C4K16_RS12255	COG0673	inositol 2-dehydrogenase activity
C4K16_RS12260	COG1082	Xylose isomerase domain protein TIM barrel
C4K16_RS12265	COG0673	inositol 2-dehydrogenase activity
C4K16_RS12280	COG1129	ABC transporter
C4K16_RS12285	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4K16_RS12335	COG4774	siderophore transport
C4K16_RS12350	COG1320	monovalent cation:proton antiporter activity
C4K16_RS12355	COG2212	antiporter activity
C4K16_RS12365	COG0651	ATP synthesis coupled electron transport
C4K16_RS12370	COG1006	Multisubunit Na H antiporter MnhC subunit
C4K16_RS12375	COG2111	Na H antiporter
C4K16_RS12375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4K16_RS12445	COG0673	inositol 2-dehydrogenase activity
C4K16_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS12465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K16_RS12470	COG1335	isochorismatase
C4K16_RS12485	COG3383	formate dehydrogenase (NAD+) activity
C4K16_RS12495	COG0814	amino acid
C4K16_RS12525	COG0589	response to stress
C4K16_RS12535	COG0745	RESPONSE REGULATOR receiver
C4K16_RS12540	COG2205	protein histidine kinase activity
C4K16_RS12555	COG3791	Glutathione-dependent formaldehyde-activating
C4K16_RS12570	COG0583	DNA-binding transcription factor activity
C4K16_RS12575	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4K16_RS12580	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS12585	COG2079	MmgE PrpD family protein
C4K16_RS12640	COG0431	NADPH-dependent FMN reductase
C4K16_RS12705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K16_RS12740	COG0583	DNA-binding transcription factor activity
C4K16_RS12750	COG1942	4-Oxalocrotonate Tautomerase
C4K16_RS12780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K16_RS12795	COG0673	inositol 2-dehydrogenase activity
C4K16_RS12805	COG1609	Transcriptional regulator
C4K16_RS12865	COG0596	Alpha beta hydrolase
C4K16_RS12870	COG2384	SAM-dependent methyltransferase
C4K16_RS12875	COG0789	Transcriptional regulator
C4K16_RS12945	COG2080	2 iron, 2 sulfur cluster binding
C4K16_RS12950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4K16_RS12955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K16_RS12960	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS12985	COG1733	regulation of RNA biosynthetic process
C4K16_RS13010	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS13020	COG1566	PFAM secretion protein HlyD family protein
C4K16_RS13030	COG2828	Protein conserved in bacteria
C4K16_RS13035	COG2207	Transcriptional regulator
C4K16_RS13055	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K16_RS13060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4K16_RS13105	COG2084	Dehydrogenase
C4K16_RS13110	COG3395	kinase activity
C4K16_RS13115	COG0235	Class ii aldolase
C4K16_RS13120	COG2610	gluconate transmembrane transporter activity
C4K16_RS13125	COG3622	Belongs to the hyi family
C4K16_RS13135	COG1349	DNA-binding transcription factor activity
C4K16_RS13230	COG1902	pentaerythritol trinitrate reductase activity
C4K16_RS13235	COG4221	oxidoreductase activity
C4K16_RS13240	COG0596	Alpha beta hydrolase
C4K16_RS13240	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4K16_RS13245	COG3321	synthase
C4K16_RS13245	COG0604	alcohol dehydrogenase
C4K16_RS13250	COG2199	diguanylate cyclase activity
C4K16_RS13250	COG2202	Pas domain
C4K16_RS13250	COG2200	EAL domain
C4K16_RS13260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS13265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4K16_RS13280	COG0494	nUDIX hydrolase
C4K16_RS13290	COG3220	belongs to the UPF0276 family
C4K16_RS13300	COG2259	Doxx family
C4K16_RS13310	COG2205	protein histidine kinase activity
C4K16_RS13355	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS13370	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K16_RS13390	COG0754	glutathionylspermidine amidase activity
C4K16_RS13400	COG3766	membrane
C4K16_RS13420	COG1842	Phage shock protein A
C4K16_RS13455	COG0583	DNA-binding transcription factor activity
C4K16_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS13485	COG4172	Belongs to the ABC transporter superfamily
C4K16_RS13490	COG4239	(ABC) transporter, permease
C4K16_RS13495	COG4174	ABC transporter (Permease)
C4K16_RS13500	COG4166	transmembrane transport
C4K16_RS13505	COG4166	transmembrane transport
C4K16_RS13510	COG1388	LysM domain
C4K16_RS13510	COG0741	lytic transglycosylase activity
C4K16_RS13515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K16_RS13525	COG0328	RNA-DNA hybrid ribonuclease activity
C4K16_RS13540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K16_RS13565	COG0431	NADPH-dependent FMN reductase
C4K16_RS13570	COG0640	Transcriptional regulator
C4K16_RS13585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4K16_RS13590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K16_RS13600	COG3139	Protein of unknown function (DUF1315)
C4K16_RS13610	COG0308	aminopeptidase N
C4K16_RS13615	COG0659	secondary active sulfate transmembrane transporter activity
C4K16_RS13635	COG2706	6-phosphogluconolactonase activity
C4K16_RS13665	COG0420	3'-5' exonuclease activity
C4K16_RS13725	COG0714	Associated with various cellular activities
C4K16_RS13730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS13735	COG0477	Major facilitator Superfamily
C4K16_RS13740	COG0579	oxidoreductase
C4K16_RS13745	COG2186	Transcriptional regulator
C4K16_RS13775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K16_RS13930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K16_RS13945	COG1794	racemase activity, acting on amino acids and derivatives
C4K16_RS13980	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K16_RS13985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K16_RS14020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K16_RS14025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K16_RS14030	COG1538	Outer membrane efflux protein
C4K16_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS14045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS14050	COG0348	domain, Protein
C4K16_RS14060	COG1285	pathogenesis
C4K16_RS14080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K16_RS14090	COG3568	Endonuclease Exonuclease Phosphatase
C4K16_RS14115	COG1640	4-alpha-glucanotransferase
C4K16_RS14120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K16_RS14125	COG0297	glycogen (starch) synthase activity
C4K16_RS14130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K16_RS14140	COG1238	metal cluster binding
C4K16_RS14180	COG0667	Aldo Keto reductase
C4K16_RS14185	COG0583	DNA-binding transcription factor activity
C4K16_RS14200	COG2366	antibiotic biosynthetic process
C4K16_RS14265	COG0583	DNA-binding transcription factor activity
C4K16_RS14275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K16_RS14275	COG1017	nitric oxide dioxygenase activity
C4K16_RS14285	COG2066	Belongs to the glutaminase family
C4K16_RS14295	COG2233	PERMEase
C4K16_RS14305	COG0010	Belongs to the arginase family
C4K16_RS14320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K16_RS14355	COG2194	sulfuric ester hydrolase activity
C4K16_RS14360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4K16_RS14365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4K16_RS14370	COG0561	phosphatase activity
C4K16_RS14375	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K16_RS14380	COG2030	dehydratase
C4K16_RS14380	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS14395	COG3162	membrane
C4K16_RS14400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K16_RS14405	COG2151	metal-sulfur cluster biosynthetic enzyme
C4K16_RS14410	COG3396	Phenylacetate-CoA oxygenase
C4K16_RS14415	COG3460	Phenylacetate-CoA oxygenase
C4K16_RS14420	COG3396	Phenylacetate-CoA oxygenase
C4K16_RS14430	COG0183	Belongs to the thiolase family
C4K16_RS14435	COG2050	protein possibly involved in aromatic compounds catabolism
C4K16_RS14440	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS14445	COG1024	Enoyl-CoA hydratase
C4K16_RS14450	COG1024	Enoyl-CoA hydratase
C4K16_RS14460	COG3327	negative regulation of DNA-templated transcription, initiation
C4K16_RS14470	COG2204	response regulator
C4K16_RS14515	COG0840	transmembrane signaling receptor activity
C4K16_RS14520	COG1968	undecaprenyl-diphosphatase activity
C4K16_RS14540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K16_RS14555	COG0488	(ABC) transporter
C4K16_RS14575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4K16_RS14585	COG2133	pyrroloquinoline quinone binding
C4K16_RS14595	COG0189	ligase activity
C4K16_RS14600	COG0598	Magnesium transport protein CorA
C4K16_RS14605	COG0024	Methionine aminopeptidase
C4K16_RS14620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K16_RS14625	COG4574	serine-type endopeptidase inhibitor activity
C4K16_RS14695	COG0726	polysaccharide deacetylase
C4K16_RS14705	COG0463	Glycosyl transferase, family 2
C4K16_RS14785	COG1175	transmembrane transport
C4K16_RS14795	COG4774	siderophore transport
C4K16_RS14800	COG2207	Transcriptional regulator
C4K16_RS14805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K16_RS14815	COG0183	Belongs to the thiolase family
C4K16_RS14820	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS14825	COG1024	Enoyl-CoA hydratase
C4K16_RS14830	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS14835	COG1024	Enoyl-CoA hydratase
C4K16_RS14850	COG2814	Major facilitator Superfamily
C4K16_RS14880	COG0765	amino acid transport
C4K16_RS14885	COG0165	Argininosuccinate lyase
C4K16_RS14910	COG2076	Multidrug Resistance protein
C4K16_RS14915	COG2076	Multidrug Resistance protein
C4K16_RS14920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K16_RS14925	COG0726	polysaccharide deacetylase
C4K16_RS14930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS14930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K16_RS14935	COG0463	Glycosyl transferase, family 2
C4K16_RS14940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K16_RS14945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K16_RS14950	COG0642	Histidine kinase
C4K16_RS14965	COG1131	(ABC) transporter
C4K16_RS15000	COG0747	negative chemotaxis
C4K16_RS15020	COG0667	Aldo Keto reductase
C4K16_RS15025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K16_RS15030	COG4172	Belongs to the ABC transporter superfamily
C4K16_RS15045	COG0477	Major facilitator Superfamily
C4K16_RS15065	COG0405	Gamma-glutamyltransferase
C4K16_RS15095	COG0589	response to stress
C4K16_RS15145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS15150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K16_RS15165	COG1024	Enoyl-CoA hydratase
C4K16_RS15165	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS15170	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS15200	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS15210	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS15215	COG0183	Belongs to the thiolase family
C4K16_RS15220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS15225	COG1231	oxidoreductase activity
C4K16_RS15240	COG2863	cytochrome
C4K16_RS15260	COG0251	oxidation-reduction process
C4K16_RS15270	COG0745	RESPONSE REGULATOR receiver
C4K16_RS15310	COG3209	COG3209 Rhs family protein
C4K16_RS15315	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
C4K16_RS15345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K16_RS15350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K16_RS15385	COG4608	Belongs to the ABC transporter superfamily
C4K16_RS15390	COG0444	Belongs to the ABC transporter superfamily
C4K16_RS15395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K16_RS15400	COG0601	transmembrane transport
C4K16_RS15405	COG0747	negative chemotaxis
C4K16_RS15410	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4K16_RS15420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K16_RS15425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4K16_RS15430	COG3540	Alkaline phosphatase
C4K16_RS15455	COG0811	peptide transport
C4K16_RS15465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K16_RS15495	COG2084	Dehydrogenase
C4K16_RS15520	COG1116	anion transmembrane transporter activity
C4K16_RS15525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS15530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS15535	COG0235	Class ii aldolase
C4K16_RS15540	COG0583	DNA-binding transcription factor activity
C4K16_RS15560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS15570	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS15575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K16_RS15595	COG4206	TonB-dependent receptor
C4K16_RS15615	COG2828	Protein conserved in bacteria
C4K16_RS15620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4K16_RS15625	COG2851	Citrate transporter
C4K16_RS15650	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C4K16_RS15675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K16_RS15680	COG0475	glutathione-regulated potassium exporter activity
C4K16_RS15710	COG3264	Mechanosensitive ion channel
C4K16_RS15710	COG1196	nuclear chromosome segregation
C4K16_RS15715	COG3204	pilus organization
C4K16_RS15720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K16_RS15730	COG0463	Glycosyl transferase, family 2
C4K16_RS15740	COG3706	GGDEF domain
C4K16_RS15745	COG0583	DNA-binding transcription factor activity
C4K16_RS15750	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS15760	COG2323	membrane
C4K16_RS15770	COG1058	Belongs to the CinA family
C4K16_RS15770	COG1546	Belongs to the CinA family
C4K16_RS15830	COG0247	lactate metabolic process
C4K16_RS15830	COG0277	FAD linked oxidase domain protein
C4K16_RS15835	COG0583	DNA-binding transcription factor activity
C4K16_RS15850	COG4104	PAAR repeat-containing protein
C4K16_RS15880	COG2146	nitrite reductase [NAD(P)H] activity
C4K16_RS15880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K16_RS15885	COG2146	nitrite reductase [NAD(P)H] activity
C4K16_RS15885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K16_RS15890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K16_RS15900	COG1120	ATPase activity
C4K16_RS15905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K16_RS15910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K16_RS15915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K16_RS15920	COG4264	IucA IucC family
C4K16_RS15930	COG4264	IucA IucC family
C4K16_RS15935	COG2814	Major facilitator Superfamily
C4K16_RS15940	COG0019	diaminopimelate decarboxylase activity
C4K16_RS15945	COG4264	IucA IucC family
C4K16_RS15950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K16_RS15955	COG4774	siderophore transport
C4K16_RS15960	COG3712	iron ion homeostasis
C4K16_RS15965	COG1595	DNA-templated transcription, initiation
C4K16_RS15985	COG0174	glutamine synthetase
C4K16_RS15995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS16040	COG0784	Response regulator, receiver
C4K16_RS16040	COG2205	protein histidine kinase activity
C4K16_RS16070	COG1522	sequence-specific DNA binding
C4K16_RS16080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K16_RS16090	COG0473	3-isopropylmalate dehydrogenase activity
C4K16_RS16125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K16_RS16130	COG0601	transmembrane transport
C4K16_RS16135	COG0747	negative chemotaxis
C4K16_RS16140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS16150	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS16180	COG0589	response to stress
C4K16_RS16185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS16190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS16195	COG1116	anion transmembrane transporter activity
C4K16_RS16210	COG1917	Cupin 2, conserved barrel domain protein
C4K16_RS16210	COG4977	sequence-specific DNA binding
C4K16_RS16265	COG0656	L-ascorbic acid biosynthetic process
C4K16_RS16270	COG0784	Response regulator, receiver
C4K16_RS16270	COG2205	protein histidine kinase activity
C4K16_RS16275	COG5001	Diguanylate cyclase
C4K16_RS16275	COG3300	MHYT domain
C4K16_RS16285	COG2197	response regulator
C4K16_RS16325	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K16_RS16330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K16_RS16375	COG1113	amino acid transport
C4K16_RS16395	COG0531	amino acid
C4K16_RS16420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K16_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS16445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS16460	COG0210	DNA helicase
C4K16_RS16475	COG3321	synthase
C4K16_RS16475	COG0604	alcohol dehydrogenase
C4K16_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS16490	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS16505	COG3469	chitinase activity
C4K16_RS16510	COG3397	chitin binding
C4K16_RS16515	COG0583	DNA-binding transcription factor activity
C4K16_RS16535	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS16555	COG2072	flavoprotein involved in K transport
C4K16_RS16560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS16565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS16570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS16585	COG1566	PFAM secretion protein HlyD family protein
C4K16_RS16610	COG2205	protein histidine kinase activity
C4K16_RS16610	COG2198	Histidine kinase
C4K16_RS16610	COG0784	Response regulator, receiver
C4K16_RS16620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K16_RS16625	COG2198	Histidine kinase
C4K16_RS16625	COG2205	protein histidine kinase activity
C4K16_RS16625	COG0784	Response regulator, receiver
C4K16_RS16645	COG0672	)-iron permease
C4K16_RS16650	COG2822	iron ion transport
C4K16_RS16665	COG2814	Major facilitator Superfamily
C4K16_RS16675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K16_RS16690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS16705	COG2816	NAD+ diphosphatase activity
C4K16_RS16710	COG1024	Enoyl-CoA hydratase
C4K16_RS16725	COG1335	isochorismatase
C4K16_RS16730	COG2205	protein histidine kinase activity
C4K16_RS16735	COG0745	RESPONSE REGULATOR receiver
C4K16_RS16740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS16775	COG1609	Transcriptional regulator
C4K16_RS16785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K16_RS16850	COG2814	Major facilitator Superfamily
C4K16_RS16855	COG1063	alcohol dehydrogenase
C4K16_RS16895	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS16900	COG3384	dioxygenase
C4K16_RS16910	COG2271	Major facilitator Superfamily
C4K16_RS16915	COG3971	2-oxopent-4-enoate hydratase activity
C4K16_RS16925	COG1929	Belongs to the glycerate kinase type-1 family
C4K16_RS16930	COG3835	regulator
C4K16_RS16935	COG2271	Major facilitator Superfamily
C4K16_RS16940	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS16950	COG0583	DNA-binding transcription factor activity
C4K16_RS16955	COG0667	Aldo Keto reductase
C4K16_RS16965	COG1846	Transcriptional regulator
C4K16_RS16975	COG0697	spore germination
C4K16_RS16980	COG0583	DNA-binding transcription factor activity
C4K16_RS16985	COG2200	EAL domain
C4K16_RS17050	COG3258	Cytochrome c
C4K16_RS17055	COG2863	cytochrome
C4K16_RS17075	COG3145	DNA-N1-methyladenine dioxygenase activity
C4K16_RS17080	COG2169	Transcriptional regulator
C4K16_RS17080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K16_RS17090	COG0604	alcohol dehydrogenase
C4K16_RS17115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4K16_RS17125	COG0488	(ABC) transporter
C4K16_RS17135	COG0393	Putative heavy-metal-binding
C4K16_RS17240	COG3179	chitinase
C4K16_RS17260	COG0583	DNA-binding transcription factor activity
C4K16_RS17265	COG0583	DNA-binding transcription factor activity
C4K16_RS17275	COG0300	oxidoreductase activity
C4K16_RS17285	COG0583	DNA-binding transcription factor activity
C4K16_RS17290	COG1309	transcriptional regulator
C4K16_RS17315	COG0475	glutathione-regulated potassium exporter activity
C4K16_RS17320	COG1024	Enoyl-CoA hydratase
C4K16_RS17325	COG0515	serine threonine protein kinase
C4K16_RS17330	COG1073	alpha beta
C4K16_RS17345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS17350	COG0789	Transcriptional regulator
C4K16_RS17365	COG3604	Transcriptional regulator
C4K16_RS17370	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C4K16_RS17395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K16_RS17400	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K16_RS17415	COG3712	iron ion homeostasis
C4K16_RS17420	COG1595	DNA-templated transcription, initiation
C4K16_RS17460	COG0583	DNA-binding transcription factor activity
C4K16_RS17465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS17480	COG0861	Integral membrane protein TerC family
C4K16_RS17490	COG0583	DNA-binding transcription factor activity
C4K16_RS17495	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS17500	COG2271	Major facilitator Superfamily
C4K16_RS17505	COG3959	Transketolase, thiamine diphosphate binding domain
C4K16_RS17510	COG3958	Transketolase
C4K16_RS17560	COG2207	Transcriptional regulator
C4K16_RS17565	COG1064	alcohol dehydrogenase
C4K16_RS17605	COG1022	Amp-dependent synthetase and ligase
C4K16_RS17610	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS17615	COG1024	Enoyl-CoA hydratase
C4K16_RS17630	COG2814	Major facilitator Superfamily
C4K16_RS17645	COG1136	(ABC) transporter
C4K16_RS17645	COG0577	efflux transmembrane transporter activity
C4K16_RS17650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS17695	COG3121	Chaperone
C4K16_RS17720	COG2197	response regulator
C4K16_RS17725	COG1538	Outer membrane efflux protein
C4K16_RS17750	COG1045	serine acetyltransferase
C4K16_RS17755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K16_RS17770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS17785	COG3622	Belongs to the hyi family
C4K16_RS17805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K16_RS17815	COG1136	(ABC) transporter
C4K16_RS17820	COG0515	serine threonine protein kinase
C4K16_RS17820	COG2815	serine threonine protein kinase
C4K16_RS17955	COG4191	Histidine kinase
C4K16_RS17960	COG4566	intracellular signal transduction
C4K16_RS17965	COG4566	intracellular signal transduction
C4K16_RS18000	COG0583	DNA-binding transcription factor activity
C4K16_RS18005	COG1335	isochorismatase
C4K16_RS18010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K16_RS18030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4K16_RS18065	COG1741	Belongs to the pirin family
C4K16_RS18090	COG1335	isochorismatase
C4K16_RS18110	COG2814	Major facilitator Superfamily
C4K16_RS18115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K16_RS18115	COG2010	Cytochrome c
C4K16_RS18120	COG2080	2 iron, 2 sulfur cluster binding
C4K16_RS18125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K16_RS18125	COG2010	Cytochrome c
C4K16_RS18130	COG1902	pentaerythritol trinitrate reductase activity
C4K16_RS18135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS18135	COG2205	protein histidine kinase activity
C4K16_RS18140	COG1301	dicarboxylic acid transport
C4K16_RS18150	COG2207	Transcriptional regulator
C4K16_RS18155	COG0300	oxidoreductase activity
C4K16_RS18160	COG0702	epimerase
C4K16_RS18165	COG0583	DNA-binding transcription factor activity
C4K16_RS18175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K16_RS18180	COG1733	regulation of RNA biosynthetic process
C4K16_RS18185	COG0583	DNA-binding transcription factor activity
C4K16_RS18200	COG0583	DNA-binding transcription factor activity
C4K16_RS18240	COG1126	abc transporter atp-binding protein
C4K16_RS18245	COG4597	amino acid ABC transporter
C4K16_RS18250	COG0765	amino acid transport
C4K16_RS18260	COG0583	DNA-binding transcription factor activity
C4K16_RS18280	COG4774	siderophore transport
C4K16_RS18305	COG2011	ABC-type metal ion transport system permease component
C4K16_RS18310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K16_RS18330	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS18335	COG1063	alcohol dehydrogenase
C4K16_RS18340	COG1024	Enoyl-CoA hydratase
C4K16_RS18345	COG4771	TonB-dependent receptor
C4K16_RS18360	COG2199	diguanylate cyclase activity
C4K16_RS18360	COG2203	Gaf domain
C4K16_RS18375	COG2851	Citrate transporter
C4K16_RS18385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K16_RS18390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K16_RS18400	COG1414	Transcriptional regulator
C4K16_RS18435	COG0322	excinuclease ABC activity
C4K16_RS18440	COG2197	response regulator
C4K16_RS18460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K16_RS18465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4K16_RS18470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K16_RS18475	COG4166	transmembrane transport
C4K16_RS18480	COG4174	ABC transporter (Permease)
C4K16_RS18485	COG4239	(ABC) transporter, permease
C4K16_RS18490	COG4172	Belongs to the ABC transporter superfamily
C4K16_RS18500	COG2610	gluconate transmembrane transporter activity
C4K16_RS18505	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS18510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K16_RS18520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K16_RS18525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K16_RS18560	COG1607	acyl-coa hydrolase
C4K16_RS18565	COG0069	glutamate synthase activity
C4K16_RS18570	COG2026	Addiction module toxin, RelE StbE family
C4K16_RS18620	COG1253	flavin adenine dinucleotide binding
C4K16_RS18655	COG0583	DNA-binding transcription factor activity
C4K16_RS18715	COG0316	Belongs to the HesB IscA family
C4K16_RS18715	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4K16_RS18750	COG0616	signal peptide processing
C4K16_RS18765	COG4172	Belongs to the ABC transporter superfamily
C4K16_RS18770	COG4239	(ABC) transporter, permease
C4K16_RS18775	COG4174	ABC transporter (Permease)
C4K16_RS18780	COG4166	transmembrane transport
C4K16_RS18790	COG4206	TonB-dependent receptor
C4K16_RS18800	COG1595	DNA-templated transcription, initiation
C4K16_RS18805	COG1024	Enoyl-CoA hydratase
C4K16_RS18805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS18825	COG3189	MarR family transcriptional regulator
C4K16_RS18830	COG2186	Transcriptional regulator
C4K16_RS18900	COG4191	Histidine kinase
C4K16_RS18900	COG0784	Response regulator, receiver
C4K16_RS18905	COG0587	DNA-directed DNA polymerase activity
C4K16_RS18920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K16_RS18940	COG2194	sulfuric ester hydrolase activity
C4K16_RS18960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS18975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4K16_RS18980	COG2188	Transcriptional regulator
C4K16_RS18985	COG0673	inositol 2-dehydrogenase activity
C4K16_RS19020	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS19030	COG0303	'Molybdopterin
C4K16_RS19035	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K16_RS19040	COG0746	molybdenum cofactor guanylyltransferase activity
C4K16_RS19045	COG0583	DNA-binding transcription factor activity
C4K16_RS19060	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K16_RS19065	COG3781	membrane
C4K16_RS19070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K16_RS19080	COG1271	oxidase subunit
C4K16_RS19085	COG1294	oxidase, subunit
C4K16_RS19100	COG0243	molybdopterin cofactor binding
C4K16_RS19105	COG0697	spore germination
C4K16_RS19110	COG1522	sequence-specific DNA binding
C4K16_RS19165	COG2989	Protein conserved in bacteria
C4K16_RS19180	COG5001	Diguanylate cyclase
C4K16_RS19180	COG3300	MHYT domain
C4K16_RS19190	COG1858	cytochrome C peroxidase
C4K16_RS19215	COG0579	oxidoreductase
C4K16_RS19265	COG2920	part of a sulfur-relay system
C4K16_RS19270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K16_RS19275	COG0435	Glutathione S-transferase
C4K16_RS19280	COG1648	precorrin-2 dehydrogenase activity
C4K16_RS19280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K16_RS19285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4K16_RS19290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4K16_RS19295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4K16_RS19300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4K16_RS19305	COG1674	ftsk spoiiie
C4K16_RS19310	COG0492	ferredoxin-NADP+ reductase activity
C4K16_RS19315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4K16_RS19320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4K16_RS19325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4K16_RS19330	COG0542	response to heat
C4K16_RS19335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4K16_RS19340	COG1278	Cold shock
C4K16_RS19365	COG0482	sulfurtransferase activity
C4K16_RS19370	COG2915	High frequency lysogenization protein hflD homolog
C4K16_RS19380	COG2850	peptidyl-arginine hydroxylation
C4K16_RS19385	COG2153	protein acetylation
C4K16_RS19400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K16_RS19405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K16_RS19410	COG0649	NAD binding
C4K16_RS19410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K16_RS19425	COG1034	ATP synthesis coupled electron transport
C4K16_RS19430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4K16_RS19435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K16_RS19445	COG0713	ATP synthesis coupled electron transport
C4K16_RS19460	COG1007	ATP synthesis coupled electron transport
C4K16_RS19465	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4K16_RS19470	COG2944	sequence-specific DNA binding
C4K16_RS19485	COG0395	ABC-type sugar transport system, permease component
C4K16_RS19495	COG3842	ATPase activity
C4K16_RS19500	COG3842	ATPase activity
C4K16_RS19505	COG3284	Transcriptional regulator
C4K16_RS19520	COG0215	cysteine-tRNA ligase activity
C4K16_RS19525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K16_RS19535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K16_RS19540	COG2814	Major facilitator Superfamily
C4K16_RS19545	COG1566	PFAM secretion protein HlyD family protein
C4K16_RS19555	COG1846	Transcriptional regulator
C4K16_RS19560	COG2911	Protein conserved in bacteria
C4K16_RS19565	COG0729	surface antigen
C4K16_RS19575	COG0708	Exodeoxyribonuclease III
C4K16_RS19585	COG2885	chlorophyll binding
C4K16_RS19600	COG0789	Transcriptional regulator
C4K16_RS19610	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS19615	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS19620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K16_RS19635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K16_RS19645	COG2866	Carboxypeptidase
C4K16_RS19655	COG2814	Major facilitator Superfamily
C4K16_RS19660	COG3038	cytochrome b561
C4K16_RS19715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K16_RS19725	COG0217	transcriptional regulatory protein
C4K16_RS19730	COG0583	DNA-binding transcription factor activity
C4K16_RS19735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4K16_RS19740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K16_RS19745	COG3038	cytochrome b561
C4K16_RS19755	COG1902	pentaerythritol trinitrate reductase activity
C4K16_RS19755	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K16_RS19780	COG2814	Major facilitator Superfamily
C4K16_RS19785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K16_RS19795	COG0776	regulation of translation
C4K16_RS19800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K16_RS19805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4K16_RS19810	COG0740	serine-type endopeptidase activity
C4K16_RS19815	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4K16_RS19835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4K16_RS19840	COG1686	Belongs to the peptidase S11 family
C4K16_RS19850	COG1253	flavin adenine dinucleotide binding
C4K16_RS19860	COG0583	DNA-binding transcription factor activity
C4K16_RS19870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4K16_RS19880	COG3132	Protein of unknown function, DUF480
C4K16_RS19890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K16_RS19910	COG0628	permease
C4K16_RS19915	COG0826	peptidase U32
C4K16_RS19925	COG2056	Na+-H+ antiporter family
C4K16_RS19930	COG0840	transmembrane signaling receptor activity
C4K16_RS19960	COG0720	synthase
C4K16_RS19970	COG0596	Alpha beta hydrolase
C4K16_RS19980	COG1051	belongs to the nudix hydrolase family
C4K16_RS19995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K16_RS20000	COG0402	S-adenosylhomocysteine deaminase activity
C4K16_RS20005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K16_RS20020	COG1725	Transcriptional regulator
C4K16_RS20025	COG2207	Transcriptional regulator
C4K16_RS20035	COG0583	DNA-binding transcription factor activity
C4K16_RS20045	COG1522	sequence-specific DNA binding
C4K16_RS20055	COG2223	nitrite transmembrane transporter activity
C4K16_RS20060	COG4772	TonB-dependent receptor
C4K16_RS20070	COG1595	DNA-templated transcription, initiation
C4K16_RS20075	COG1335	isochorismatase
C4K16_RS20110	COG1294	oxidase, subunit
C4K16_RS20115	COG1271	oxidase subunit
C4K16_RS20120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K16_RS20150	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K16_RS20160	COG2197	response regulator
C4K16_RS20165	COG0784	Response regulator, receiver
C4K16_RS20165	COG2205	protein histidine kinase activity
C4K16_RS20180	COG3121	Chaperone
C4K16_RS20185	COG3539	Fimbrial protein
C4K16_RS20235	COG2274	protein secretion by the type I secretion system
C4K16_RS20240	COG1538	Outer membrane efflux protein
C4K16_RS20245	COG2080	2 iron, 2 sulfur cluster binding
C4K16_RS20250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K16_RS20250	COG2010	Cytochrome c
C4K16_RS20255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K16_RS20255	COG2010	Cytochrome c
C4K16_RS20270	COG0840	transmembrane signaling receptor activity
C4K16_RS20275	COG4774	siderophore transport
C4K16_RS20280	COG0583	DNA-binding transcription factor activity
C4K16_RS20290	COG3591	Belongs to the peptidase S1B family
C4K16_RS20290	COG1864	DNA RNA non-specific endonuclease
C4K16_RS20310	COG4106	trans-aconitate 2-methyltransferase activity
C4K16_RS20330	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4K16_RS20360	COG2814	Major facilitator Superfamily
C4K16_RS20390	COG3485	protocatechuate 3,4-dioxygenase
C4K16_RS20395	COG4829	muconolactone delta-isomerase
C4K16_RS20400	COG4948	Mandelate Racemase Muconate Lactonizing
C4K16_RS20430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K16_RS20480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4K16_RS20495	COG2814	Major facilitator Superfamily
C4K16_RS20525	COG0154	amidase activity
C4K16_RS20530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K16_RS20565	COG3012	SEC-C Motif Domain Protein
C4K16_RS20565	COG3318	Belongs to the UPF0149 family
C4K16_RS20570	COG0730	response to heat
C4K16_RS20595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K16_RS20605	COG1335	isochorismatase
C4K16_RS20610	COG1335	isochorismatase
C4K16_RS20620	COG0583	DNA-binding transcription factor activity
C4K16_RS20630	COG0656	L-ascorbic acid biosynthetic process
C4K16_RS20665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS20670	COG1136	(ABC) transporter
C4K16_RS20670	COG0577	efflux transmembrane transporter activity
C4K16_RS20675	COG1538	Outer membrane efflux protein
C4K16_RS20730	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4K16_RS20745	COG1309	transcriptional regulator
C4K16_RS20750	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS20755	COG3387	PFAM Glycoside hydrolase 15-related
C4K16_RS20770	COG0596	Alpha beta hydrolase
C4K16_RS20810	COG4977	sequence-specific DNA binding
C4K16_RS20820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K16_RS20825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4K16_RS20890	COG0840	transmembrane signaling receptor activity
C4K16_RS20925	COG1132	(ABC) transporter
C4K16_RS20930	COG3284	Transcriptional regulator
C4K16_RS20960	COG0477	Major facilitator Superfamily
C4K16_RS20965	COG0583	DNA-binding transcription factor activity
C4K16_RS20970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K16_RS20975	COG0235	Class ii aldolase
C4K16_RS20980	COG0477	Major facilitator Superfamily
C4K16_RS20985	COG0583	DNA-binding transcription factor activity
C4K16_RS20990	COG0768	penicillin binding
C4K16_RS21000	COG1063	alcohol dehydrogenase
C4K16_RS21035	COG5006	permease, DMT superfamily
C4K16_RS21045	COG1309	transcriptional regulator
C4K16_RS21050	COG0300	oxidoreductase activity
C4K16_RS21075	COG0431	NADPH-dependent FMN reductase
C4K16_RS21080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS21090	COG3829	transcription factor binding
C4K16_RS21135	COG1121	(ABC) transporter
C4K16_RS21140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K16_RS21150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K16_RS21165	COG0642	Histidine kinase
C4K16_RS21175	COG4232	protein-disulfide reductase activity
C4K16_RS21180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4K16_RS21205	COG2267	carboxylic ester hydrolase activity
C4K16_RS21230	COG1309	transcriptional regulator
C4K16_RS21245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K16_RS21250	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS21270	COG3123	guanosine phosphorylase activity
C4K16_RS21275	COG0633	Ferredoxin
C4K16_RS21275	COG3217	Mosc domain protein beta barrel domain protein
C4K16_RS21290	COG3851	Histidine kinase
C4K16_RS21295	COG2197	response regulator
C4K16_RS21300	COG1597	lipid kinase activity
C4K16_RS21310	COG0303	'Molybdopterin
C4K16_RS21315	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K16_RS21320	COG0746	molybdenum cofactor guanylyltransferase activity
C4K16_RS21330	COG0564	pseudouridine synthase activity
C4K16_RS21355	COG0004	ammonium transporteR
C4K16_RS21375	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K16_RS21395	COG2197	response regulator
C4K16_RS21400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS21400	COG2205	protein histidine kinase activity
C4K16_RS21405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4K16_RS21410	COG1956	GAF domain-containing protein
C4K16_RS21420	COG0784	Response regulator, receiver
C4K16_RS21420	COG5002	protein histidine kinase activity
C4K16_RS21420	COG2205	protein histidine kinase activity
C4K16_RS21425	COG1846	Transcriptional regulator
C4K16_RS21430	COG0386	Belongs to the glutathione peroxidase family
C4K16_RS21435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K16_RS21440	COG0436	Aminotransferase
C4K16_RS21445	COG0501	Belongs to the peptidase M48B family
C4K16_RS21450	COG0500	methyltransferase
C4K16_RS21455	COG3384	dioxygenase
C4K16_RS21470	COG1024	Enoyl-CoA hydratase
C4K16_RS21480	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4K16_RS21485	COG3214	Protein conserved in bacteria
C4K16_RS21495	COG0583	DNA-binding transcription factor activity
C4K16_RS21505	COG0583	DNA-binding transcription factor activity
C4K16_RS21510	COG1846	Transcriptional regulator
C4K16_RS21515	COG1764	response to oxidative stress
C4K16_RS21525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4K16_RS21540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K16_RS21560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K16_RS21590	COG1376	ErfK ybiS ycfS ynhG family protein
C4K16_RS21605	COG4181	ATPase activity
C4K16_RS21610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4K16_RS21615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K16_RS21630	COG2197	response regulator
C4K16_RS21640	COG2259	Doxx family
C4K16_RS21645	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K16_RS21650	COG0084	hydrolase, TatD family'
C4K16_RS21685	COG0745	RESPONSE REGULATOR receiver
C4K16_RS21690	COG2205	protein histidine kinase activity
C4K16_RS21695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4K16_RS21705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4K16_RS21740	COG4221	oxidoreductase activity
C4K16_RS21775	COG0776	regulation of translation
C4K16_RS21790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4K16_RS21795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4K16_RS21800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K16_RS21810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4K16_RS21820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4K16_RS21825	COG0402	S-adenosylhomocysteine deaminase activity
C4K16_RS21830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K16_RS21835	COG0546	phosphoglycolate phosphatase activity
C4K16_RS21840	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS21855	COG5002	protein histidine kinase activity
C4K16_RS21855	COG5001	Diguanylate cyclase
C4K16_RS21870	COG1054	Belongs to the UPF0176 family
C4K16_RS21875	COG0271	Belongs to the BolA IbaG family
C4K16_RS21885	COG0114	fumarate hydratase activity
C4K16_RS21890	COG0697	spore germination
C4K16_RS21895	COG0183	Belongs to the thiolase family
C4K16_RS21900	COG2326	polyphosphate kinase activity
C4K16_RS21905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS21905	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4K16_RS21910	COG0367	asparagine synthase
C4K16_RS21915	COG0189	ligase activity
C4K16_RS21915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K16_RS21920	COG1363	Peptidase, m42
C4K16_RS21925	COG3089	Belongs to the UPF0270 family
C4K16_RS21930	COG1742	UPF0060 membrane protein
C4K16_RS21945	COG1368	sulfuric ester hydrolase activity
C4K16_RS21965	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS21975	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C4K16_RS21980	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4K16_RS21985	COG0235	Class ii aldolase
C4K16_RS21995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4K16_RS22000	COG1073	alpha beta
C4K16_RS22025	COG2840	Smr protein MutS2
C4K16_RS22030	COG0302	gtp cyclohydrolase
C4K16_RS22040	COG0625	glutathione transferase activity
C4K16_RS22045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS22055	COG2252	PERMEase
C4K16_RS22080	COG4266	Belongs to the allantoicase family
C4K16_RS22085	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4K16_RS22095	COG2233	PERMEase
C4K16_RS22120	COG1560	Kdo2-lipid A biosynthetic process
C4K16_RS22125	COG0850	regulation of cytokinetic process
C4K16_RS22130	COG2894	cell division
C4K16_RS22135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4K16_RS22140	COG0564	pseudouridine synthase activity
C4K16_RS22150	COG1362	aminopeptidase activity
C4K16_RS22155	COG0668	transmembrane transport
C4K16_RS22160	COG1473	amidohydrolase
C4K16_RS22190	COG3842	ATPase activity
C4K16_RS22200	COG0604	alcohol dehydrogenase
C4K16_RS22200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K16_RS22200	COG3321	synthase
C4K16_RS22200	COG4221	oxidoreductase activity
C4K16_RS22210	COG2200	EAL domain
C4K16_RS22235	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K16_RS22240	COG2010	Cytochrome c
C4K16_RS22270	COG2974	May be involved in recombination
C4K16_RS22275	COG0385	Bile acid
C4K16_RS22280	COG2076	Multidrug Resistance protein
C4K16_RS22310	COG2205	protein histidine kinase activity
C4K16_RS22310	COG2202	Pas domain
C4K16_RS22360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4K16_RS22365	COG0406	alpha-ribazole phosphatase activity
C4K16_RS22370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4K16_RS22380	COG1492	cobalamin metabolic process
C4K16_RS22395	COG0778	Nitroreductase
C4K16_RS22400	COG1797	cobyrinic acid a,c-diamide synthase activity
C4K16_RS22425	COG0791	NLP P60 protein
C4K16_RS22430	COG0791	NLP P60 protein
C4K16_RS22435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K16_RS22440	COG0628	permease
C4K16_RS22450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4K16_RS22455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4K16_RS22470	COG3122	Protein conserved in bacteria
C4K16_RS22475	COG3956	TIGRFAM MazG family protein
C4K16_RS22480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K16_RS22485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K16_RS22505	COG0784	Response regulator, receiver
C4K16_RS22505	COG2205	protein histidine kinase activity
C4K16_RS22505	COG5002	protein histidine kinase activity
C4K16_RS22510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K16_RS22530	COG1393	Belongs to the ArsC family
C4K16_RS22550	COG0037	tRNA processing
C4K16_RS22560	COG3091	SprT-like family
C4K16_RS22565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K16_RS22605	COG2205	protein histidine kinase activity
C4K16_RS22610	COG0745	RESPONSE REGULATOR receiver
C4K16_RS22615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K16_RS22615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K16_RS22630	COG1558	bacterial-type flagellum-dependent cell motility
C4K16_RS22635	COG1815	bacterial-type flagellum-dependent cell motility
C4K16_RS22640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K16_RS22645	COG0784	Response regulator, receiver
C4K16_RS22645	COG0835	chemotaxis
C4K16_RS22665	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4K16_RS22670	COG0477	Major facilitator Superfamily
C4K16_RS22680	COG2205	protein histidine kinase activity
C4K16_RS22710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS22740	COG2239	Acts as a magnesium transporter
C4K16_RS22760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K16_RS22765	COG0527	aspartate kinase activity
C4K16_RS22770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K16_RS22775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4K16_RS22780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K16_RS22785	COG2988	succinylglutamate desuccinylase activity
C4K16_RS22795	COG3724	N-succinylarginine dihydrolase activity
C4K16_RS22800	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS22815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K16_RS22845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS22850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K16_RS22860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K16_RS22895	COG0563	adenylate kinase activity
C4K16_RS22910	COG3706	GGDEF domain
C4K16_RS22930	COG0504	CTP synthase activity
C4K16_RS22935	COG2329	Antibiotic biosynthesis monooxygenase
C4K16_RS22945	COG0584	glycerophosphoryl diester phosphodiesterase
C4K16_RS22975	COG0306	phosphate transporter
C4K16_RS22985	COG3008	intermembrane lipid transfer
C4K16_RS22990	COG2995	paraquat-inducible protein a
C4K16_RS22995	COG2995	paraquat-inducible protein a
C4K16_RS23010	COG0583	DNA-binding transcription factor activity
C4K16_RS23015	COG4941	Belongs to the sigma-70 factor family
C4K16_RS23025	COG3795	YCII-related domain
C4K16_RS23070	COG0436	Aminotransferase
C4K16_RS23080	COG3265	gluconokinase activity
C4K16_RS23085	COG1609	Transcriptional regulator
C4K16_RS23090	COG0583	DNA-binding transcription factor activity
C4K16_RS23100	COG0625	glutathione transferase activity
C4K16_RS23105	COG2271	Major facilitator Superfamily
C4K16_RS23115	COG0583	DNA-binding transcription factor activity
C4K16_RS23125	COG2986	histidine ammonia-lyase
C4K16_RS23135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS23150	COG3712	iron ion homeostasis
C4K16_RS23155	COG1595	DNA-templated transcription, initiation
C4K16_RS23180	COG0242	peptide deformylase activity
C4K16_RS23185	COG1295	ribonuclease BN
C4K16_RS23200	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS23205	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS23210	COG2267	carboxylic ester hydrolase activity
C4K16_RS23215	COG2030	dehydratase
C4K16_RS23245	COG3530	Putative quorum-sensing-regulated virulence factor
C4K16_RS23250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K16_RS23255	COG0800	Aldolase
C4K16_RS23270	COG1737	Transcriptional regulator
C4K16_RS23275	COG0676	glucose-6-phosphate 1-epimerase activity
C4K16_RS23285	COG3842	ATPase activity
C4K16_RS23290	COG0395	ABC-type sugar transport system, permease component
C4K16_RS23295	COG1175	transmembrane transport
C4K16_RS23300	COG1653	transport
C4K16_RS23335	COG1803	Methylglyoxal synthase
C4K16_RS23345	COG3712	iron ion homeostasis
C4K16_RS23350	COG4771	TonB-dependent receptor
C4K16_RS23360	COG2832	Protein of unknown function (DUF454)
C4K16_RS23365	COG0840	transmembrane signaling receptor activity
C4K16_RS23370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K16_RS23390	COG2235	arginine
C4K16_RS23395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K16_RS23415	COG0509	glycine decarboxylation via glycine cleavage system
C4K16_RS23420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K16_RS23420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K16_RS23425	COG1760	l-serine dehydratase
C4K16_RS23435	COG1278	Cold shock
C4K16_RS23445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4K16_RS23540	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K16_RS23545	COG1129	ABC transporter
C4K16_RS23550	COG1879	ABC-type sugar transport system periplasmic component
C4K16_RS23560	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS23590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K16_RS23595	COG0602	queuosine metabolic process
C4K16_RS23600	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4K16_RS23605	COG2885	chlorophyll binding
C4K16_RS23610	COG0823	Involved in the tonB-independent uptake of proteins
C4K16_RS23630	COG0824	Thioesterase
C4K16_RS23635	COG2255	four-way junction helicase activity
C4K16_RS23640	COG0632	four-way junction helicase activity
C4K16_RS23645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4K16_RS23650	COG0217	transcriptional regulatory protein
C4K16_RS23655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4K16_RS23665	COG0783	Belongs to the Dps family
C4K16_RS23675	COG2900	Belongs to the SlyX family
C4K16_RS23695	COG0668	transmembrane transport
C4K16_RS23700	COG1666	GTP binding
C4K16_RS23710	COG4191	Histidine kinase
C4K16_RS23710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS23715	COG2096	Adenosyltransferase
C4K16_RS23720	COG0352	thiamine-phosphate diphosphorylase activity
C4K16_RS23730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4K16_RS23735	COG0653	protein targeting
C4K16_RS23745	COG0433	COG0433 Predicted ATPase
C4K16_RS23755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K16_RS23755	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS23785	COG2925	Exonuclease
C4K16_RS23810	COG0714	Associated with various cellular activities
C4K16_RS23830	COG0469	pyruvate kinase activity
C4K16_RS23845	COG3706	GGDEF domain
C4K16_RS23860	COG4191	Histidine kinase
C4K16_RS23870	COG0477	Major facilitator Superfamily
C4K16_RS23900	COG2207	Transcriptional regulator
C4K16_RS23905	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS23915	COG0583	DNA-binding transcription factor activity
C4K16_RS23920	COG2910	NAD(P)H-binding
C4K16_RS23930	COG0583	DNA-binding transcription factor activity
C4K16_RS23960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K16_RS23965	COG0583	DNA-binding transcription factor activity
C4K16_RS23980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4K16_RS24015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS24020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K16_RS24030	COG3642	lipopolysaccharide core region biosynthetic process
C4K16_RS24040	COG0642	Histidine kinase
C4K16_RS24055	COG0459	protein refolding
C4K16_RS24060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4K16_RS24070	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4K16_RS24080	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS24085	COG0489	protein tyrosine kinase activity
C4K16_RS24090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K16_RS24090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K16_RS24095	COG4657	Part of a membrane complex involved in electron transport
C4K16_RS24100	COG2878	Part of a membrane complex involved in electron transport
C4K16_RS24105	COG4658	electron transport chain
C4K16_RS24115	COG4660	Part of a membrane complex involved in electron transport
C4K16_RS24120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4K16_RS24130	COG2197	response regulator
C4K16_RS24135	COG0137	argininosuccinate synthase activity
C4K16_RS24145	COG0418	dihydroorotase activity
C4K16_RS24150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K16_RS24155	COG0450	alkyl hydroperoxide reductase
C4K16_RS24170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4K16_RS24175	COG3383	formate dehydrogenase (NAD+) activity
C4K16_RS24185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K16_RS24190	COG3842	ATPase activity
C4K16_RS24200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4K16_RS24210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4K16_RS24230	COG0765	amino acid transport
C4K16_RS24235	COG0765	amino acid transport
C4K16_RS24240	COG1126	abc transporter atp-binding protein
C4K16_RS24270	COG2076	Multidrug Resistance protein
C4K16_RS24290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K16_RS24305	COG4191	Histidine kinase
C4K16_RS24310	COG2204	response regulator
C4K16_RS24315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K16_RS24320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4K16_RS24325	COG0583	DNA-binding transcription factor activity
C4K16_RS24330	COG0456	acetyltransferase
C4K16_RS24335	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS24345	COG0254	rRNA binding
C4K16_RS24355	COG0069	glutamate synthase activity
C4K16_RS24380	COG2246	polysaccharide biosynthetic process
C4K16_RS24395	COG1113	amino acid transport
C4K16_RS24405	COG1695	Transcriptional regulator
C4K16_RS24410	COG2375	cellular response to nickel ion
C4K16_RS24420	COG4628	conserved protein (DUF2132)
C4K16_RS24425	COG4206	TonB-dependent receptor
C4K16_RS24460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K16_RS24475	COG2226	methyltransferase
C4K16_RS24480	COG0500	methyltransferase
C4K16_RS24485	COG0590	tRNA wobble adenosine to inosine editing
C4K16_RS24500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K16_RS24500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K16_RS24515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K16_RS24515	COG1263	PTS System
C4K16_RS24520	COG2188	Transcriptional regulator
C4K16_RS24545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K16_RS24545	COG0519	Catalyzes the synthesis of GMP from XMP
C4K16_RS24570	COG1570	exodeoxyribonuclease VII activity
C4K16_RS24575	COG0739	heme binding
C4K16_RS24580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K16_RS24595	COG0436	Aminotransferase
C4K16_RS24600	COG1160	GTP binding
C4K16_RS24615	COG0124	histidyl-tRNA synthetase
C4K16_RS24620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4K16_RS24625	COG1426	Protein conserved in bacteria
C4K16_RS24635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4K16_RS24640	COG0105	UTP biosynthetic process
C4K16_RS24650	COG0633	Ferredoxin
C4K16_RS24655	COG0443	Heat shock 70 kDa protein
C4K16_RS24660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K16_RS24675	COG1104	cysteine desulfurase activity
C4K16_RS24685	COG1045	serine acetyltransferase
C4K16_RS24715	COG1862	Preprotein translocase
C4K16_RS24720	COG0343	queuine tRNA-ribosyltransferase activity
C4K16_RS24725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4K16_RS24735	COG0582	viral genome integration into host DNA
C4K16_RS24840	COG2853	Lipoprotein
C4K16_RS24880	COG0586	Pfam SNARE associated Golgi protein
C4K16_RS24885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K16_RS24925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K16_RS24940	COG5322	oxidoreductase activity
C4K16_RS24940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K16_RS24945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K16_RS24955	COG2771	luxR family
C4K16_RS24960	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS24980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K16_RS24995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K16_RS25000	COG0109	protoheme IX farnesyltransferase activity
C4K16_RS25010	COG1845	cytochrome c oxidase, subunit III
C4K16_RS25015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K16_RS25020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K16_RS25030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K16_RS25040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K16_RS25040	COG1017	nitric oxide dioxygenase activity
C4K16_RS25045	COG3604	Transcriptional regulator
C4K16_RS25050	COG0835	chemotaxis
C4K16_RS25050	COG0784	Response regulator, receiver
C4K16_RS25080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K16_RS25090	COG5002	protein histidine kinase activity
C4K16_RS25105	COG3706	GGDEF domain
C4K16_RS25105	COG2203	Gaf domain
C4K16_RS25105	COG5001	Diguanylate cyclase
C4K16_RS25105	COG4251	negative regulation of phosphorylation
C4K16_RS25110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4K16_RS25115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4K16_RS25130	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K16_RS25135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K16_RS25140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K16_RS25145	COG0772	Belongs to the SEDS family
C4K16_RS25150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4K16_RS25155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K16_RS25160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4K16_RS25165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K16_RS25180	COG0275	rRNA processing
C4K16_RS25185	COG2001	Belongs to the MraZ family
C4K16_RS25200	COG3107	peptidoglycan biosynthetic process
C4K16_RS25205	COG0792	nuclease activity
C4K16_RS25210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4K16_RS25215	COG2823	Periplasmic or secreted lipoprotein
C4K16_RS25220	COG2969	positive regulation of protein catabolic process
C4K16_RS25225	COG0625	glutathione transferase activity
C4K16_RS25230	COG2857	Cytochrome c1
C4K16_RS25235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4K16_RS25240	COG0723	plastoquinol--plastocyanin reductase activity
C4K16_RS25245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4K16_RS25250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4K16_RS25255	COG0667	Aldo Keto reductase
C4K16_RS25260	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS25270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K16_RS25275	COG0180	Tryptophanyl-tRNA synthetase
C4K16_RS25295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K16_RS25310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4K16_RS25320	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS25350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K16_RS25360	COG2771	luxR family
C4K16_RS25365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K16_RS25380	COG0745	RESPONSE REGULATOR receiver
C4K16_RS25385	COG0642	Histidine kinase
C4K16_RS25390	COG2909	trisaccharide binding
C4K16_RS25405	COG0318	PFAM AMP-dependent synthetase and ligase
C4K16_RS25425	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS25430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K16_RS25435	COG2813	Specifically methylates the guanine in position
C4K16_RS25440	COG2119	membrane
C4K16_RS25445	COG0501	Belongs to the peptidase M48B family
C4K16_RS25450	COG0840	transmembrane signaling receptor activity
C4K16_RS25455	COG2135	peptidase activity
C4K16_RS25515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4K16_RS25520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4K16_RS25530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4K16_RS25535	COG1090	epimerase
C4K16_RS25540	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4K16_RS25550	COG0789	Transcriptional regulator
C4K16_RS25555	COG0415	Belongs to the DNA photolyase family
C4K16_RS25570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4K16_RS25575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4K16_RS25585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4K16_RS25590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4K16_RS25600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4K16_RS25605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4K16_RS25615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4K16_RS25620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4K16_RS25625	COG0193	aminoacyl-tRNA hydrolase activity
C4K16_RS25640	COG0583	DNA-binding transcription factor activity
C4K16_RS25645	COG2197	response regulator
C4K16_RS25650	COG2205	protein histidine kinase activity
C4K16_RS25650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS25655	COG3397	chitin binding
C4K16_RS25720	COG2258	MOSC domain
C4K16_RS25725	COG2223	nitrite transmembrane transporter activity
C4K16_RS25735	COG0583	DNA-binding transcription factor activity
C4K16_RS25740	COG3842	ATPase activity
C4K16_RS25745	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K16_RS25750	COG1177	transmembrane transport
C4K16_RS25820	COG0405	Gamma-glutamyltransferase
C4K16_RS25835	COG4680	protein conserved in bacteria
C4K16_RS25850	COG0789	Transcriptional regulator
C4K16_RS25865	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K16_RS25880	COG3655	Transcriptional regulator
C4K16_RS25900	COG0662	Cupin 2, conserved barrel domain protein
C4K16_RS25910	COG0583	DNA-binding transcription factor activity
C4K16_RS25915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K16_RS25920	COG1028	Short-chain dehydrogenase reductase Sdr
C4K16_RS25925	COG0583	DNA-binding transcription factor activity
C4K16_RS25995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K16_RS26010	COG2031	fatty acid transporter
C4K16_RS26025	COG0288	reversible hydration of carbon dioxide
C4K16_RS26035	COG0456	acetyltransferase
C4K16_RS26060	COG3008	intermembrane lipid transfer
C4K16_RS26065	COG2995	paraquat-inducible protein a
C4K16_RS26070	COG2995	paraquat-inducible protein a
C4K16_RS26105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4K16_RS26110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4K16_RS26115	COG1183	phosphatidylcholine synthase activity
C4K16_RS26120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4K16_RS26130	COG0028	Belongs to the TPP enzyme family
C4K16_RS26150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K16_RS26180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4K16_RS26185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K16_RS26190	COG4558	Periplasmic binding protein
C4K16_RS26200	COG1489	DNA binding
C4K16_RS26205	COG0436	Aminotransferase
C4K16_RS26215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K16_RS26225	COG4191	Histidine kinase
C4K16_RS26250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K16_RS26255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4K16_RS26265	COG0166	Belongs to the GPI family
C4K16_RS26270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K16_RS26285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K16_RS26295	COG2823	Periplasmic or secreted lipoprotein
C4K16_RS26310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4K16_RS26315	COG0237	dephospho-CoA kinase activity
C4K16_RS26320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4K16_RS26340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K16_RS26395	COG0728	peptidoglycan biosynthetic process
C4K16_RS26410	COG1252	NADH dehydrogenase
C4K16_RS26420	COG3121	Chaperone
C4K16_RS26425	COG3188	usher protein
C4K16_RS26455	COG0542	response to heat
C4K16_RS26485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS26525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4K16_RS26530	COG1047	Peptidyl-prolyl cis-trans
C4K16_RS26535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4K16_RS26540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4K16_RS26545	COG0196	riboflavin kinase activity
C4K16_RS26560	COG0268	Binds directly to 16S ribosomal RNA
C4K16_RS26565	COG3045	CreA protein
C4K16_RS26570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4K16_RS26575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4K16_RS26580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4K16_RS26585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4K16_RS26590	COG0142	geranyltranstransferase activity
C4K16_RS26595	COG2824	Alkylphosphonate utilization operon protein PhnA
C4K16_RS26600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K16_RS26605	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K16_RS26615	COG2862	Uncharacterized protein family, UPF0114
C4K16_RS26630	COG1067	ATP-dependent peptidase activity
C4K16_RS26650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K16_RS26660	COG0488	(ABC) transporter
C4K16_RS26670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K16_RS26685	COG2186	Transcriptional regulator
C4K16_RS26695	COG0523	cobalamin synthesis protein
C4K16_RS26700	COG2879	small protein
C4K16_RS26705	COG1966	Carbon starvation protein
C4K16_RS26710	COG2020	methyltransferase activity
C4K16_RS26740	COG1970	mechanosensitive ion channel activity
C4K16_RS26750	COG2813	Specifically methylates the guanine in position
C4K16_RS26760	COG1294	oxidase, subunit
C4K16_RS26765	COG1271	oxidase subunit
C4K16_RS26790	COG2252	PERMEase
C4K16_RS26795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K16_RS26800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K16_RS26805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K16_RS26810	COG3135	benzoate transporter
C4K16_RS26820	COG1309	transcriptional regulator
C4K16_RS26825	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4K16_RS26825	COG1082	Xylose isomerase domain protein TIM barrel
C4K16_RS26845	COG0673	inositol 2-dehydrogenase activity
C4K16_RS26855	COG1053	succinate dehydrogenase
C4K16_RS26860	COG3485	protocatechuate 3,4-dioxygenase
C4K16_RS26865	COG3485	protocatechuate 3,4-dioxygenase
C4K16_RS26870	COG0583	DNA-binding transcription factor activity
C4K16_RS26875	COG2321	neutral zinc metallopeptidase
C4K16_RS26890	COG1946	Acyl-CoA thioesterase
C4K16_RS26900	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4K16_RS26910	COG0513	Belongs to the DEAD box helicase family
C4K16_RS26920	COG0697	spore germination
C4K16_RS26925	COG1522	sequence-specific DNA binding
C4K16_RS26930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K16_RS26930	COG1199	ATP-dependent helicase activity
C4K16_RS26940	COG3416	Protein conserved in bacteria
C4K16_RS26955	COG1643	Atp-dependent helicase
C4K16_RS26975	COG1522	sequence-specific DNA binding
C4K16_RS26990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K16_RS26995	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS27000	COG2198	Histidine kinase
C4K16_RS27000	COG2205	protein histidine kinase activity
C4K16_RS27000	COG0784	Response regulator, receiver
C4K16_RS27005	COG0351	phosphomethylpyrimidine kinase
C4K16_RS27010	COG0352	thiamine-phosphate diphosphorylase activity
C4K16_RS27015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K16_RS27030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K16_RS27035	COG1702	phosphate starvation-inducible protein PhoH
C4K16_RS27040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4K16_RS27045	COG4535	Mg2 and Co2 transporter CorC
C4K16_RS27055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4K16_RS27070	COG0495	leucyl-tRNA aminoacylation
C4K16_RS27090	COG2951	lytic endotransglycosylase activity
C4K16_RS27095	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4K16_RS27100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4K16_RS27105	COG0321	lipoyl(octanoyl) transferase activity
C4K16_RS27110	COG2921	Belongs to the UPF0250 family
C4K16_RS27115	COG1686	Belongs to the peptidase S11 family
C4K16_RS27125	COG2951	lytic endotransglycosylase activity
C4K16_RS27130	COG0772	Belongs to the SEDS family
C4K16_RS27135	COG0768	penicillin binding
C4K16_RS27140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4K16_RS27150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4K16_RS27155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4K16_RS27160	COG2094	Belongs to the DNA glycosylase MPG family
C4K16_RS27165	COG0586	Pfam SNARE associated Golgi protein
C4K16_RS27175	COG1346	cytolysis
C4K16_RS27195	COG0702	epimerase
C4K16_RS27210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K16_RS27215	COG3284	Transcriptional regulator
C4K16_RS27230	COG4303	Ethanolamine ammonia lyase large subunit
C4K16_RS27235	COG4302	ethanolamine ammonia-lyase activity
C4K16_RS27240	COG0456	acetyltransferase
C4K16_RS27245	COG0586	Pfam SNARE associated Golgi protein
C4K16_RS27250	COG3228	Belongs to the MtfA family
C4K16_RS27255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4K16_RS27270	COG2070	2-Nitropropane dioxygenase
C4K16_RS27280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K16_RS27285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS27290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K16_RS27295	COG0473	3-isopropylmalate dehydrogenase activity
C4K16_RS27295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K16_RS27300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K16_RS27310	COG2814	Major facilitator Superfamily
C4K16_RS27325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS27340	COG0583	DNA-binding transcription factor activity
C4K16_RS27345	COG2207	Transcriptional regulator
C4K16_RS27355	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K16_RS27360	COG3657	addiction module killer protein
C4K16_RS27370	COG3321	synthase
C4K16_RS27370	COG0604	alcohol dehydrogenase
C4K16_RS27375	COG0640	Transcriptional regulator
C4K16_RS27390	COG1722	exodeoxyribonuclease VII activity
C4K16_RS27395	COG0142	geranyltranstransferase activity
C4K16_RS27400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4K16_RS27405	COG4206	TonB-dependent receptor
C4K16_RS27420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4K16_RS27430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4K16_RS27440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4K16_RS27445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K16_RS27460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K16_RS27460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K16_RS27465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K16_RS27475	COG2264	protein methyltransferase activity
C4K16_RS27480	COG3118	belongs to the thioredoxin family
C4K16_RS27510	COG3047	cAMP biosynthetic process
C4K16_RS27525	COG1201	RNA secondary structure unwinding
C4K16_RS27530	COG2814	Major facilitator Superfamily
C4K16_RS27540	COG3568	Endonuclease Exonuclease Phosphatase
C4K16_RS27545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K16_RS27550	COG0392	lysyltransferase activity
C4K16_RS27570	COG1335	isochorismatase
C4K16_RS27575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K16_RS27620	COG0629	single-stranded DNA binding
C4K16_RS27630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4K16_RS27635	COG2193	ferroxidase activity
C4K16_RS27645	COG0203	ribosomal protein L17
C4K16_RS27650	COG0202	RNA polymerase activity
C4K16_RS27655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4K16_RS27660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4K16_RS27665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4K16_RS27670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4K16_RS27680	COG0200	Binds to the 23S rRNA
C4K16_RS27685	COG1841	ribosomal large subunit assembly
C4K16_RS27690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4K16_RS27695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4K16_RS27700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4K16_RS27705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4K16_RS27710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4K16_RS27715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4K16_RS27720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4K16_RS27725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4K16_RS27730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4K16_RS27735	COG0255	Belongs to the universal ribosomal protein uL29 family
C4K16_RS27740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4K16_RS27745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4K16_RS27750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4K16_RS27755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4K16_RS27760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4K16_RS27765	COG0089	rRNA binding
C4K16_RS27770	COG0088	Forms part of the polypeptide exit tunnel
C4K16_RS27775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4K16_RS27780	COG0051	transcription antitermination factor activity, RNA binding
C4K16_RS27785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K16_RS27790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K16_RS27795	COG0049	tRNA binding
C4K16_RS27800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4K16_RS27805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4K16_RS27810	COG0085	RNA polymerase activity
C4K16_RS27815	COG0222	ribosome binding
C4K16_RS27820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4K16_RS27825	COG0081	regulation of translation
C4K16_RS27830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4K16_RS27850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K16_RS27915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4K16_RS27920	COG0739	heme binding
C4K16_RS27925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4K16_RS27930	COG0316	Belongs to the HesB IscA family
C4K16_RS27935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K16_RS27940	COG1981	membrane
C4K16_RS27955	COG4221	oxidoreductase activity
C4K16_RS27960	COG0537	adenosine 5'-monophosphoramidase activity
C4K16_RS27965	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4K16_RS27970	COG1765	OsmC-like protein
C4K16_RS27985	COG0134	indole-3-glycerol-phosphate synthase activity
C4K16_RS27990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K16_RS27995	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K16_RS28005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K16_RS28010	COG0546	phosphoglycolate phosphatase activity
C4K16_RS28015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4K16_RS28020	COG1454	alcohol dehydrogenase
C4K16_RS28030	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K16_RS28040	COG3842	ATPase activity
C4K16_RS28045	COG2197	response regulator
C4K16_RS28050	COG4585	Histidine kinase
C4K16_RS28060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K16_RS28065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K16_RS28070	COG3178	'Phosphotransferase
C4K16_RS28075	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4K16_RS28080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K16_RS28085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4K16_RS28090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4K16_RS28095	COG2967	ApaG domain
C4K16_RS28100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K16_RS28105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K16_RS28110	COG2766	serine protein kinase
C4K16_RS28115	COG2718	Belongs to the UPF0229 family
C4K16_RS28120	COG2719	SpoVR family
C4K16_RS28125	COG0617	tRNA 3'-terminal CCA addition
C4K16_RS28135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K16_RS28140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4K16_RS28145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4K16_RS28150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4K16_RS28155	COG0358	DNA primase activity
C4K16_RS28160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4K16_RS28195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K16_RS28200	COG1025	Belongs to the peptidase M16 family
C4K16_RS28210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K16_RS28215	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4K16_RS28225	COG0535	radical SAM domain protein
C4K16_RS28250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K16_RS28255	COG2258	MOSC domain
C4K16_RS28260	COG0583	DNA-binding transcription factor activity
C4K16_RS28265	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS28270	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS28275	COG3706	GGDEF domain
C4K16_RS28280	COG1960	acyl-CoA dehydrogenase activity
C4K16_RS28300	COG1073	alpha beta
C4K16_RS28300	COG2226	methyltransferase
C4K16_RS28305	COG0156	8-amino-7-oxononanoate synthase activity
C4K16_RS28310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4K16_RS28320	COG2005	Transcriptional regulator
C4K16_RS28320	COG3585	molybdate ion transport
C4K16_RS28330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4K16_RS28345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4K16_RS28365	COG1595	DNA-templated transcription, initiation
C4K16_RS28370	COG3712	iron ion homeostasis
C4K16_RS28375	COG4774	siderophore transport
C4K16_RS28395	COG0625	glutathione transferase activity
C4K16_RS28400	COG4452	Inner membrane protein CreD
C4K16_RS28405	COG2205	protein histidine kinase activity
C4K16_RS28410	COG0745	RESPONSE REGULATOR receiver
C4K16_RS28415	COG4067	protein conserved in archaea
C4K16_RS28415	COG0189	ligase activity
C4K16_RS28420	COG0204	Acyl-transferase
C4K16_RS28450	COG1063	alcohol dehydrogenase
C4K16_RS28480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K16_RS28495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K16_RS28510	COG1017	nitric oxide dioxygenase activity
C4K16_RS28510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K16_RS28520	COG4638	Rieske (2fe-2S)
C4K16_RS28530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4K16_RS28535	COG2181	nitrate reductase activity
C4K16_RS28535	COG0247	lactate metabolic process
C4K16_RS28540	COG1902	pentaerythritol trinitrate reductase activity
C4K16_RS28540	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K16_RS28590	COG3246	L-lysine catabolic process to acetate
C4K16_RS28595	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K16_RS28630	COG1760	l-serine dehydratase
C4K16_RS28640	COG4176	ABC-type proline glycine betaine transport system permease component
C4K16_RS28645	COG4175	Glycine betaine
C4K16_RS28650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K16_RS28655	COG1309	transcriptional regulator
C4K16_RS28660	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS28665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K16_RS28680	COG0312	modulator of DNA gyrase
C4K16_RS28685	COG0477	Major facilitator Superfamily
C4K16_RS28690	COG0513	Belongs to the DEAD box helicase family
C4K16_RS28695	COG2081	HI0933 family
C4K16_RS28700	COG1289	transmembrane transporter activity
C4K16_RS28710	COG2153	protein acetylation
C4K16_RS28720	COG1451	nucleotide metabolic process
C4K16_RS28750	COG0126	phosphoglycerate kinase activity
C4K16_RS28755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4K16_RS28765	COG4106	trans-aconitate 2-methyltransferase activity
C4K16_RS28770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4K16_RS28775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K16_RS28780	COG1422	Protein of unknown function (DUF1090)
C4K16_RS28805	COG2814	Major facilitator Superfamily
C4K16_RS28815	COG2116	formate transmembrane transporter activity
C4K16_RS28825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4K16_RS28830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4K16_RS28845	COG0513	Belongs to the DEAD box helicase family
C4K16_RS28850	COG2353	YceI-like domain
C4K16_RS28855	COG3038	cytochrome b561
C4K16_RS28865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4K16_RS28890	COG1272	protein, Hemolysin III
C4K16_RS28910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K16_RS28930	COG3052	prosthetic group binding
C4K16_RS28935	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4K16_RS28960	COG0643	Histidine kinase
C4K16_RS28960	COG2198	Histidine kinase
C4K16_RS28960	COG0784	Response regulator, receiver
C4K16_RS28985	COG0189	ligase activity
C4K16_RS28995	COG1678	Uncharacterized ACR, COG1678
C4K16_RS29000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4K16_RS29005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4K16_RS29010	COG0540	Belongs to the ATCase OTCase family
C4K16_RS29015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K16_RS29025	COG0791	NLP P60 protein
C4K16_RS29050	COG1872	DUF167
C4K16_RS29055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K16_RS29060	COG2813	Specifically methylates the guanine in position
C4K16_RS29060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K16_RS29070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4K16_RS29075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4K16_RS29085	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C4K16_RS29090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4K16_RS29095	COG2022	thiamine diphosphate biosynthetic process
C4K16_RS29105	COG2363	Small membrane protein
C4K16_RS29110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K16_RS29120	COG2177	Part of the ABC transporter FtsEX involved in
C4K16_RS29125	COG2884	Cell division ATP-binding protein ftsE
C4K16_RS29130	COG0552	protein localization to endoplasmic reticulum
C4K16_RS29140	COG0612	Peptidase, M16
C4K16_RS29145	COG0612	Peptidase, M16
C4K16_RS29150	COG0742	ribosomal rna small subunit methyltransferase
C4K16_RS29185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K16_RS29190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4K16_RS29195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4K16_RS29200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4K16_RS29210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K16_RS29220	COG0129	dihydroxy-acid dehydratase activity
C4K16_RS29245	COG1823	symporter activity
C4K16_RS29260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K16_RS29275	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K16_RS29280	COG1178	ABC-type Fe3 transport system permease component
C4K16_RS29285	COG3842	ATPase activity
C4K16_RS29290	COG0583	DNA-binding transcription factor activity
C4K16_RS29300	COG0789	Transcriptional regulator
C4K16_RS29305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4K16_RS29310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4K16_RS29315	COG0730	response to heat
C4K16_RS29325	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C4K16_RS29330	COG0494	nUDIX hydrolase
C4K16_RS29345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K16_RS29350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4K16_RS29355	COG2234	aminopeptidase activity
C4K16_RS29360	COG3204	pilus organization
C4K16_RS29365	COG3204	pilus organization
C4K16_RS29370	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K16_RS29375	COG0277	FAD linked oxidase domain protein
C4K16_RS29380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K16_RS29390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS29395	COG1683	Conserved Protein
C4K16_RS29430	COG1177	transmembrane transport
C4K16_RS29435	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K16_RS29440	COG3842	ATPase activity
C4K16_RS29460	COG0174	glutamine synthetase
C4K16_RS29465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K16_RS29470	COG0174	glutamine synthetase
C4K16_RS29485	COG1116	anion transmembrane transporter activity
C4K16_RS29490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K16_RS29495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K16_RS29500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K16_RS29505	COG0431	NADPH-dependent FMN reductase
C4K16_RS29510	COG0450	alkyl hydroperoxide reductase
C4K16_RS29520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K16_RS29520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4K16_RS29525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K16_RS29535	COG1522	sequence-specific DNA binding
C4K16_RS29545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4K16_RS29555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K16_RS29555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K16_RS29560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K16_RS29575	COG0509	glycine decarboxylation via glycine cleavage system
C4K16_RS29580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K16_RS29585	COG1178	ABC-type Fe3 transport system permease component
C4K16_RS29595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K16_RS29600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K16_RS29605	COG0006	proline dipeptidase activity
C4K16_RS29610	COG3079	Belongs to the UPF0149 family
C4K16_RS29630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4K16_RS29640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K16_RS29645	COG0842	Transport permease protein
C4K16_RS29645	COG1129	ABC transporter
C4K16_RS29650	COG0842	Transport permease protein
C4K16_RS29660	COG0604	alcohol dehydrogenase
C4K16_RS29665	COG2271	Major facilitator Superfamily
C4K16_RS29680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4K16_RS29695	COG2186	Transcriptional regulator
C4K16_RS29700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS29705	COG0765	amino acid transport
C4K16_RS29710	COG0765	amino acid transport
C4K16_RS29715	COG1126	abc transporter atp-binding protein
C4K16_RS29720	COG0248	Ppx GppA phosphatase
C4K16_RS29725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4K16_RS29735	COG0586	Pfam SNARE associated Golgi protein
C4K16_RS29745	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4K16_RS29750	COG1671	Belongs to the UPF0178 family
C4K16_RS29755	COG0672	)-iron permease
C4K16_RS29760	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS29770	COG0488	(ABC) transporter
C4K16_RS29795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K16_RS29815	COG0181	hydroxymethylbilane synthase activity
C4K16_RS29825	COG0165	Argininosuccinate lyase
C4K16_RS29830	COG0625	glutathione transferase activity
C4K16_RS29845	COG3072	Adenylate cyclase
C4K16_RS29850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K16_RS29860	COG1965	Belongs to the frataxin family
C4K16_RS29870	COG0019	diaminopimelate decarboxylase activity
C4K16_RS29875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K16_RS29885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K16_RS29890	COG1011	Hydrolase
C4K16_RS29900	COG0432	Pfam Uncharacterised protein family UPF0047
C4K16_RS29905	COG0004	ammonium transporteR
C4K16_RS29910	COG0347	Belongs to the P(II) protein family
C4K16_RS29925	COG0529	Catalyzes the synthesis of activated sulfate
C4K16_RS29935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K16_RS29940	COG3848	Pyruvate phosphate dikinase
C4K16_RS29940	COG0574	Belongs to the PEP-utilizing enzyme family
C4K16_RS29945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K16_RS29950	COG1213	nucleotidyl transferase
C4K16_RS29955	COG0606	chelatase, subunit chli
C4K16_RS29985	COG0583	DNA-binding transcription factor activity
C4K16_RS29990	COG0534	Mate efflux family protein
C4K16_RS30005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K16_RS30010	COG0427	acetyl-CoA hydrolase
C4K16_RS30025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4K16_RS30030	COG0251	oxidation-reduction process
C4K16_RS30035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS30050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K16_RS30060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K16_RS30065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K16_RS30075	COG1012	belongs to the aldehyde dehydrogenase family
C4K16_RS30085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4K16_RS30090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4K16_RS30095	COG0747	negative chemotaxis
C4K16_RS30100	COG2003	Belongs to the UPF0758 family
C4K16_RS30105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4K16_RS30110	COG0756	dUTP diphosphatase activity
C4K16_RS30120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K16_RS30125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K16_RS30130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4K16_RS30135	COG0708	Exodeoxyribonuclease III
C4K16_RS30145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4K16_RS30150	COG1561	YicC-like family, N-terminal region
C4K16_RS30155	COG0194	GDP metabolic process
C4K16_RS30160	COG1758	RNA polymerase activity
C4K16_RS30165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K16_RS30190	COG0848	biopolymer transport protein
C4K16_RS30200	COG0583	DNA-binding transcription factor activity
C4K16_RS30205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4K16_RS30415	COG3161	chorismate lyase activity
C4K16_RS30420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4K16_RS30440	COG1253	flavin adenine dinucleotide binding
C4K16_RS30445	COG0739	heme binding
C4K16_RS30465	COG0704	Plays a role in the regulation of phosphate uptake
C4K16_RS30470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4K16_RS30475	COG0573	inorganic phosphate transmembrane transporter activity
C4K16_RS30490	COG0477	Major facilitator Superfamily
C4K16_RS30495	COG1607	acyl-coa hydrolase
C4K16_RS30525	COG0583	DNA-binding transcription factor activity
C4K16_RS30530	COG1027	Aspartate ammonia-lyase
C4K16_RS30540	COG1115	amino acid carrier protein
C4K16_RS30545	COG0252	asparaginase activity
C4K16_RS30600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K16_RS30620	COG0511	ligase activity, forming carbon-carbon bonds
C4K16_RS30620	COG5016	pyruvate
C4K16_RS30625	COG0439	Biotin carboxylase
C4K16_RS30630	COG0583	DNA-binding transcription factor activity
C4K16_RS30655	COG0210	DNA helicase
C4K16_RS30675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K16_RS30675	COG4651	solute:proton antiporter activity
C4K16_RS30680	COG1607	acyl-coa hydrolase
C4K16_RS30685	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4K16_RS30695	COG0523	cobalamin synthesis protein
C4K16_RS30720	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K16_RS30725	COG1469	GTP cyclohydrolase I activity
C4K16_RS30730	COG1121	(ABC) transporter
C4K16_RS30740	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4K16_RS30745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K16_RS30755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K16_RS30760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K16_RS30770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K16_RS30775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4K16_RS30800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4K16_RS30805	COG2267	carboxylic ester hydrolase activity
C4K16_RS30810	COG2453	phosphatase
C4K16_RS30810	COG0671	phosphoesterase, PA-phosphatase related
C4K16_RS30825	COG4589	Belongs to the CDS family
C4K16_RS30830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K16_RS30840	COG1280	lysine exporter protein (LysE YggA)
C4K16_RS30845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K16_RS30850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K16_RS30850	COG2755	lipolytic protein G-D-S-L family
C4K16_RS30855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K16_RS30900	COG0438	transferase activity, transferring glycosyl groups
C4K16_RS30915	COG0625	glutathione transferase activity
C4K16_RS30920	COG0583	DNA-binding transcription factor activity
C4K16_RS30925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K16_RS30940	COG0494	nUDIX hydrolase
C4K16_RS30945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K16_RS30960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K16_RS30965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K16_RS30970	COG0494	nUDIX hydrolase
C4K16_RS30985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K16_RS30990	COG1349	DNA-binding transcription factor activity
C4K16_RS30995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K16_RS31000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4K16_RS31005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4K16_RS31010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4K16_RS31015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4K16_RS31020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4K16_RS31025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4K16_RS31035	COG0356	it plays a direct role in the translocation of protons across the membrane
C4K16_RS31040	COG3312	ion transport
C4K16_RS31045	COG1475	DNA binding
C4K16_RS31050	COG1192	Involved in chromosome partitioning
C4K16_RS31055	COG0357	Ribosomal RNA small subunit methyltransferase G
C4K16_RS31060	COG0445	tRNA wobble uridine modification
C4K16_RS31070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K16_RS31075	COG0706	membrane insertase activity
C4K16_RS31080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4K16_RS31085	COG0594	ribonuclease P activity
C4K16_RS31090	COG0230	Belongs to the bacterial ribosomal protein bL34 family