locus-tag	class	description
C4K15_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K15_RS00010	COG0592	DNA-directed DNA polymerase activity
C4K15_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K15_RS00020	COG0187	DNA topoisomerase II activity
C4K15_RS00045	COG5002	protein histidine kinase activity
C4K15_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4K15_RS00060	COG0751	glycine-tRNA ligase activity
C4K15_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
C4K15_RS00070	COG2818	Glycosylase
C4K15_RS00090	COG0569	domain protein
C4K15_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4K15_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS00105	COG0242	peptide deformylase activity
C4K15_RS00115	COG0758	DNA mediated transformation
C4K15_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
C4K15_RS00130	COG0408	coproporphyrinogen oxidase activity
C4K15_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K15_RS00150	COG3119	arylsulfatase activity
C4K15_RS00175	COG0159	tryptophan synthase activity
C4K15_RS00180	COG0133	tryptophan synthase activity
C4K15_RS00195	COG3360	Dodecin
C4K15_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS00210	COG1764	response to oxidative stress
C4K15_RS00240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4K15_RS00245	COG0339	signal peptide processing
C4K15_RS00250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4K15_RS00285	COG0659	secondary active sulfate transmembrane transporter activity
C4K15_RS00295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K15_RS00295	COG1565	acr, cog1565
C4K15_RS00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K15_RS00305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4K15_RS00335	COG0109	protoheme IX farnesyltransferase activity
C4K15_RS00350	COG2011	ABC-type metal ion transport system permease component
C4K15_RS00355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K15_RS00370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K15_RS00375	COG1121	(ABC) transporter
C4K15_RS00380	COG0735	belongs to the Fur family
C4K15_RS00385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4K15_RS00405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4K15_RS00410	COG3245	cytochrome
C4K15_RS00420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K15_RS00435	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K15_RS00440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K15_RS00445	COG5002	protein histidine kinase activity
C4K15_RS00450	COG2204	response regulator
C4K15_RS00460	COG5487	UPF0391 membrane protein
C4K15_RS00470	COG1301	dicarboxylic acid transport
C4K15_RS00475	COG0700	Nucleoside recognition
C4K15_RS00490	COG1127	ABC transporter
C4K15_RS00495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K15_RS00505	COG0612	Peptidase, M16
C4K15_RS00510	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K15_RS00515	COG0861	Integral membrane protein TerC family
C4K15_RS00520	COG2851	Citrate transporter
C4K15_RS00560	COG0427	acetyl-CoA hydrolase
C4K15_RS00580	COG0583	DNA-binding transcription factor activity
C4K15_RS00585	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS00640	COG3712	iron ion homeostasis
C4K15_RS00645	COG1595	DNA-templated transcription, initiation
C4K15_RS00650	COG0840	transmembrane signaling receptor activity
C4K15_RS00660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K15_RS00680	COG1802	Transcriptional regulator
C4K15_RS00690	COG5001	Diguanylate cyclase
C4K15_RS00690	COG3300	MHYT domain
C4K15_RS00715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS00725	COG2175	clavaminate synthase activity
C4K15_RS00735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K15_RS00740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS00755	COG2814	Major facilitator Superfamily
C4K15_RS00830	COG0529	Catalyzes the synthesis of activated sulfate
C4K15_RS00845	COG0330	HflC and HflK could
C4K15_RS00880	COG1289	transmembrane transporter activity
C4K15_RS00890	COG1566	PFAM secretion protein HlyD family protein
C4K15_RS00905	COG5339	Protein conserved in bacteria
C4K15_RS00910	COG0457	Tetratricopeptide repeat
C4K15_RS00915	COG1649	PFAM Uncharacterised BCR, COG1649
C4K15_RS00915	COG0726	polysaccharide deacetylase
C4K15_RS00920	COG1215	transferase activity, transferring glycosyl groups
C4K15_RS00930	COG1881	PFAM PEBP family protein
C4K15_RS00935	COG2304	oxidoreductase activity
C4K15_RS00940	COG1595	DNA-templated transcription, initiation
C4K15_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K15_RS01020	COG0745	RESPONSE REGULATOR receiver
C4K15_RS01025	COG2199	diguanylate cyclase activity
C4K15_RS01045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4K15_RS01055	COG4208	sulfate ABC transporter
C4K15_RS01060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4K15_RS01095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS01100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS01125	COG4771	TonB-dependent receptor
C4K15_RS01225	COG0590	tRNA wobble adenosine to inosine editing
C4K15_RS01235	COG0583	DNA-binding transcription factor activity
C4K15_RS01270	COG0765	amino acid transport
C4K15_RS01275	COG0765	amino acid transport
C4K15_RS01280	COG1126	abc transporter atp-binding protein
C4K15_RS01285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS01290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K15_RS01315	COG2011	ABC-type metal ion transport system permease component
C4K15_RS01320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K15_RS01345	COG1126	abc transporter atp-binding protein
C4K15_RS01350	COG0765	amino acid transport
C4K15_RS01355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS01360	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4K15_RS01365	COG1045	serine acetyltransferase
C4K15_RS01370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K15_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS01400	COG0583	DNA-binding transcription factor activity
C4K15_RS01415	COG1609	Transcriptional regulator
C4K15_RS01430	COG0667	Aldo Keto reductase
C4K15_RS01435	COG1487	ribonuclease activity
C4K15_RS01445	COG2175	clavaminate synthase activity
C4K15_RS01450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS01455	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K15_RS01460	COG4521	taurine ABC transporter
C4K15_RS01465	COG2918	glutathione biosynthetic process
C4K15_RS01475	COG2183	response to ionizing radiation
C4K15_RS01485	COG2205	protein histidine kinase activity
C4K15_RS01490	COG0189	ligase activity
C4K15_RS01495	COG4067	protein conserved in archaea
C4K15_RS01495	COG0189	ligase activity
C4K15_RS01500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4K15_RS01510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4K15_RS01515	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4K15_RS01555	COG0514	ATP-dependent DNA helicase (RecQ)
C4K15_RS01560	COG1024	Enoyl-CoA hydratase
C4K15_RS01560	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS01565	COG0824	Thioesterase
C4K15_RS01575	COG0243	molybdopterin cofactor binding
C4K15_RS01580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4K15_RS01590	COG1652	LysM domain
C4K15_RS01595	COG1011	Hydrolase
C4K15_RS01600	COG0494	nUDIX hydrolase
C4K15_RS01635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4K15_RS01645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K15_RS01655	COG2957	Belongs to the agmatine deiminase family
C4K15_RS01690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K15_RS01695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K15_RS01700	COG1845	cytochrome c oxidase, subunit III
C4K15_RS01705	COG1845	cytochrome c oxidase, subunit III
C4K15_RS01720	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4K15_RS01760	COG0529	Catalyzes the synthesis of activated sulfate
C4K15_RS01800	COG4215	(ABC) transporter
C4K15_RS01840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4K15_RS01845	COG1194	a g-specific adenine glycosylase
C4K15_RS01860	COG2223	nitrite transmembrane transporter activity
C4K15_RS01865	COG0131	Imidazoleglycerol-phosphate dehydratase
C4K15_RS01870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K15_RS01880	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4K15_RS01885	COG0107	imidazoleglycerol-phosphate synthase activity
C4K15_RS01895	COG2861	carbohydrate metabolic process
C4K15_RS01900	COG0793	Belongs to the peptidase S41A family
C4K15_RS01905	COG4942	peptidase
C4K15_RS01910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4K15_RS01925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4K15_RS01945	COG3852	Histidine kinase
C4K15_RS01955	COG0583	DNA-binding transcription factor activity
C4K15_RS01960	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS01965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K15_RS01970	COG1024	Enoyl-CoA hydratase
C4K15_RS01975	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS01980	COG0183	Belongs to the thiolase family
C4K15_RS02015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K15_RS02015	COG0301	tRNA thio-modification
C4K15_RS02020	COG1217	gtp-binding protein TYPA
C4K15_RS02030	COG0058	SHG alpha-glucan phosphorylase activity
C4K15_RS02035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4K15_RS02070	COG0402	S-adenosylhomocysteine deaminase activity
C4K15_RS02075	COG2188	Transcriptional regulator
C4K15_RS02085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4K15_RS02090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K15_RS02100	COG4176	ABC-type proline glycine betaine transport system permease component
C4K15_RS02105	COG4175	Glycine betaine
C4K15_RS02105	COG0517	IMP dehydrogenase activity
C4K15_RS02110	COG2986	histidine ammonia-lyase
C4K15_RS02115	COG2986	histidine ammonia-lyase
C4K15_RS02125	COG1228	amidohydrolase
C4K15_RS02135	COG0596	Alpha beta hydrolase
C4K15_RS02140	COG1490	D-aminoacyl-tRNA deacylase activity
C4K15_RS02145	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K15_RS02150	COG2943	transferase activity, transferring hexosyl groups
C4K15_RS02155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS02160	COG0765	amino acid transport
C4K15_RS02170	COG0840	transmembrane signaling receptor activity
C4K15_RS02185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K15_RS02190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K15_RS02195	COG0140	phosphoribosyl-ATP diphosphatase activity
C4K15_RS02200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K15_RS02205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K15_RS02215	COG2226	methyltransferase
C4K15_RS02260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4K15_RS02265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4K15_RS02275	COG0018	arginyl-trna synthetase
C4K15_RS02280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4K15_RS02285	COG0254	rRNA binding
C4K15_RS02295	COG0281	malic enzyme
C4K15_RS02330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K15_RS02335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K15_RS02350	COG0070	glutamate synthase
C4K15_RS02350	COG0069	glutamate synthase activity
C4K15_RS02350	COG0067	glutamate synthase
C4K15_RS02355	COG0493	'glutamate synthase
C4K15_RS02360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4K15_RS02365	COG3111	PFAM Bacterial OB fold (BOF) protein
C4K15_RS02370	COG2814	Major facilitator Superfamily
C4K15_RS02375	COG0583	DNA-binding transcription factor activity
C4K15_RS02390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K15_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS02405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K15_RS02415	COG2226	methyltransferase
C4K15_RS02445	COG2986	histidine ammonia-lyase
C4K15_RS02470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K15_RS02490	COG1192	Involved in chromosome partitioning
C4K15_RS02495	COG3118	belongs to the thioredoxin family
C4K15_RS02500	COG4680	protein conserved in bacteria
C4K15_RS02510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K15_RS02515	COG1196	nuclear chromosome segregation
C4K15_RS02515	COG3264	Mechanosensitive ion channel
C4K15_RS02520	COG3263	regulation of cellular component size
C4K15_RS02540	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS02545	COG0506	proline dehydrogenase activity
C4K15_RS02545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K15_RS02545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K15_RS02550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K15_RS02555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4K15_RS02560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K15_RS02580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4K15_RS02585	COG0859	PFAM glycosyl transferase family 9
C4K15_RS02590	COG0859	PFAM glycosyl transferase family 9
C4K15_RS02595	COG0438	transferase activity, transferring glycosyl groups
C4K15_RS02620	COG2192	nodulation
C4K15_RS02625	COG0438	transferase activity, transferring glycosyl groups
C4K15_RS02650	COG0438	transferase activity, transferring glycosyl groups
C4K15_RS02665	COG1132	(ABC) transporter
C4K15_RS02685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4K15_RS02685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4K15_RS02695	COG0667	Aldo Keto reductase
C4K15_RS02715	COG1519	Transferase
C4K15_RS02720	COG1538	Outer membrane efflux protein
C4K15_RS02725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4K15_RS02740	COG0494	nUDIX hydrolase
C4K15_RS02750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4K15_RS02755	COG3150	esterase
C4K15_RS02790	COG3830	Belongs to the UPF0237 family
C4K15_RS02790	COG0560	Phosphoserine phosphatase
C4K15_RS02795	COG0688	phosphatidylethanolamine metabolic process
C4K15_RS02820	COG1162	GTPase activity
C4K15_RS02825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4K15_RS02830	COG2860	membrane
C4K15_RS02840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4K15_RS02840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4K15_RS02845	COG0802	atpase or kinase
C4K15_RS02850	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K15_RS02855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K15_RS02860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4K15_RS02865	COG1923	regulation of RNA biosynthetic process
C4K15_RS02870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4K15_RS02875	COG0330	HflC and HflK could
C4K15_RS02880	COG0330	HflC and HflK could
C4K15_RS02885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4K15_RS02890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4K15_RS02895	COG0840	transmembrane signaling receptor activity
C4K15_RS02900	COG1178	ABC-type Fe3 transport system permease component
C4K15_RS02920	COG0557	exoribonuclease II activity
C4K15_RS02925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4K15_RS02930	COG0360	Binds together with S18 to 16S ribosomal RNA
C4K15_RS02935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4K15_RS02945	COG0359	binds to the 23S rRNA
C4K15_RS02950	COG0305	Participates in initiation and elongation during chromosome replication
C4K15_RS02955	COG1032	radical SAM domain protein
C4K15_RS02970	COG2307	Protein conserved in bacteria
C4K15_RS02970	COG2308	Evidence 4 Homologs of previously reported genes of
C4K15_RS03005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4K15_RS03010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4K15_RS03015	COG0583	DNA-binding transcription factor activity
C4K15_RS03020	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS03025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS03035	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4K15_RS03060	COG4221	oxidoreductase activity
C4K15_RS03080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4K15_RS03085	COG0830	nickel cation binding
C4K15_RS03090	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4K15_RS03105	COG2982	Protein involved in outer membrane biogenesis
C4K15_RS03110	COG0583	DNA-binding transcription factor activity
C4K15_RS03115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K15_RS03125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4K15_RS03130	COG0697	spore germination
C4K15_RS03135	COG2207	Transcriptional regulator
C4K15_RS03150	COG0443	Heat shock 70 kDa protein
C4K15_RS03155	COG0484	heat shock protein binding
C4K15_RS03160	COG0789	Transcriptional regulator
C4K15_RS03170	COG0804	urea catabolic process
C4K15_RS03175	COG0832	Belongs to the urease beta subunit family
C4K15_RS03190	COG0831	urea catabolic process
C4K15_RS03195	COG0829	nickel cation binding
C4K15_RS03205	COG0411	ABC transporter
C4K15_RS03220	COG0683	leucine binding
C4K15_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K15_RS03235	COG1120	ATPase activity
C4K15_RS03275	COG3657	addiction module killer protein
C4K15_RS03285	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4K15_RS03295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K15_RS03320	COG2095	MarC family integral membrane protein
C4K15_RS03330	COG0151	Belongs to the GarS family
C4K15_RS03335	COG0138	bifunctional purine biosynthesis protein purh
C4K15_RS03345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K15_RS03355	COG2264	protein methyltransferase activity
C4K15_RS03370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K15_RS03400	COG0023	Translation Initiation Factor
C4K15_RS03405	COG1166	arginine decarboxylase activity
C4K15_RS03410	COG0534	Mate efflux family protein
C4K15_RS03415	COG2373	Large extracellular alpha-helical protein
C4K15_RS03425	COG4953	penicillin-binding protein 1C
C4K15_RS03435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K15_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS03545	COG0840	transmembrane signaling receptor activity
C4K15_RS03560	COG2217	Heavy metal translocating P-type atpase
C4K15_RS03590	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4K15_RS03595	COG0583	DNA-binding transcription factor activity
C4K15_RS03600	COG0477	Major facilitator Superfamily
C4K15_RS03605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4K15_RS03620	COG0387	Pfam Sodium calcium exchanger
C4K15_RS03655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K15_RS03675	COG0811	peptide transport
C4K15_RS03680	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4K15_RS03685	COG4603	Belongs to the binding-protein-dependent transport system permease family
C4K15_RS03690	COG3845	ABC transporter
C4K15_RS03700	COG1309	transcriptional regulator
C4K15_RS03705	COG2233	PERMEase
C4K15_RS03755	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4K15_RS03760	COG1074	ATP-dependent DNA helicase activity
C4K15_RS03765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K15_RS03770	COG1126	abc transporter atp-binding protein
C4K15_RS03775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS03795	COG2199	diguanylate cyclase activity
C4K15_RS03850	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4K15_RS03855	COG3483	tryptophan 2,3-dioxygenase activity
C4K15_RS03860	COG1113	amino acid transport
C4K15_RS03865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K15_RS03865	COG0543	2 iron, 2 sulfur cluster binding
C4K15_RS03870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4K15_RS03875	COG4638	Rieske (2fe-2S)
C4K15_RS03885	COG1522	sequence-specific DNA binding
C4K15_RS03895	COG1113	amino acid transport
C4K15_RS03900	COG0583	DNA-binding transcription factor activity
C4K15_RS03915	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K15_RS03920	COG0583	DNA-binding transcription factor activity
C4K15_RS03935	COG2610	gluconate transmembrane transporter activity
C4K15_RS03945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4K15_RS03970	COG0840	transmembrane signaling receptor activity
C4K15_RS03990	COG3385	transposase activity
C4K15_RS04015	COG1309	transcriptional regulator
C4K15_RS04040	COG0583	DNA-binding transcription factor activity
C4K15_RS04100	COG0247	lactate metabolic process
C4K15_RS04105	COG1620	l-lactate permease
C4K15_RS04110	COG2186	Transcriptional regulator
C4K15_RS04115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4K15_RS04120	COG0733	neurotransmitter:sodium symporter activity
C4K15_RS04130	COG2914	Belongs to the UPF0125 (RnfH) family
C4K15_RS04135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4K15_RS04145	COG0497	DNA recombination
C4K15_RS04150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4K15_RS04155	COG0443	Heat shock 70 kDa protein
C4K15_RS04160	COG0484	heat shock protein binding
C4K15_RS04165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4K15_RS04170	COG0505	Belongs to the CarA family
C4K15_RS04175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4K15_RS04180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K15_RS04195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4K15_RS04205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4K15_RS04210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K15_RS04215	COG0149	triose-phosphate isomerase activity
C4K15_RS04220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4K15_RS04240	COG0195	Participates in both transcription termination and antitermination
C4K15_RS04245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4K15_RS04250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4K15_RS04255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4K15_RS04260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4K15_RS04265	COG1185	polyribonucleotide nucleotidyltransferase activity
C4K15_RS04295	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K15_RS04310	COG0084	hydrolase, TatD family'
C4K15_RS04315	COG1609	Transcriptional regulator
C4K15_RS04320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K15_RS04320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K15_RS04325	COG1105	Belongs to the carbohydrate kinase PfkB family
C4K15_RS04330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K15_RS04330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4K15_RS04330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K15_RS04345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4K15_RS04350	COG4774	siderophore transport
C4K15_RS04355	COG3128	pkhd-type hydroxylase
C4K15_RS04365	COG0019	diaminopimelate decarboxylase activity
C4K15_RS04390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4K15_RS04400	COG4608	Belongs to the ABC transporter superfamily
C4K15_RS04405	COG0444	Belongs to the ABC transporter superfamily
C4K15_RS04410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K15_RS04415	COG0601	transmembrane transport
C4K15_RS04420	COG0747	negative chemotaxis
C4K15_RS04430	COG0747	negative chemotaxis
C4K15_RS04435	COG0747	negative chemotaxis
C4K15_RS04445	COG1917	Cupin 2, conserved barrel domain protein
C4K15_RS04445	COG1396	sequence-specific DNA binding
C4K15_RS04460	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4K15_RS04465	COG4178	(ABC) transporter
C4K15_RS04470	COG2186	Transcriptional regulator
C4K15_RS04485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K15_RS04495	COG2271	Major facilitator Superfamily
C4K15_RS04500	COG2721	sulfolactate sulfo-lyase activity
C4K15_RS04510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K15_RS04520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K15_RS04525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K15_RS04530	COG0154	amidase activity
C4K15_RS04535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K15_RS04540	COG1077	Cell shape determining protein MreB Mrl
C4K15_RS04545	COG1792	Involved in formation and maintenance of cell shape
C4K15_RS04555	COG0424	maF-like protein
C4K15_RS04560	COG1530	ribonuclease E activity
C4K15_RS04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K15_RS04575	COG0312	modulator of DNA gyrase
C4K15_RS04580	COG3028	Belongs to the UPF0307 family
C4K15_RS04585	COG0312	modulator of DNA gyrase
C4K15_RS04620	COG1660	Displays ATPase and GTPase activities
C4K15_RS04635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4K15_RS04640	COG1137	ATPase activity
C4K15_RS04645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4K15_RS04655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4K15_RS04665	COG1127	ABC transporter
C4K15_RS04670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K15_RS04675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4K15_RS04695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4K15_RS04700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4K15_RS04705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K15_RS04710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K15_RS04715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K15_RS04730	COG0175	sulfate reduction
C4K15_RS04740	COG0204	Acyl-transferase
C4K15_RS04745	COG0280	phosphate acetyltransferase
C4K15_RS04745	COG0857	belongs to the CobB CobQ family
C4K15_RS04760	COG0386	Belongs to the glutathione peroxidase family
C4K15_RS04775	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4K15_RS04785	COG0492	ferredoxin-NADP+ reductase activity
C4K15_RS04800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K15_RS04805	COG0302	gtp cyclohydrolase
C4K15_RS04820	COG0789	Transcriptional regulator
C4K15_RS04830	COG1366	Belongs to the anti-sigma-factor antagonist family
C4K15_RS04840	COG0583	DNA-binding transcription factor activity
C4K15_RS04845	COG1380	Effector of murein hydrolase LrgA
C4K15_RS04850	COG1346	cytolysis
C4K15_RS04860	COG0596	Alpha beta hydrolase
C4K15_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS04885	COG2909	trisaccharide binding
C4K15_RS04895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4K15_RS04900	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K15_RS04920	COG2226	methyltransferase
C4K15_RS04965	COG0814	amino acid
C4K15_RS04970	COG1760	l-serine dehydratase
C4K15_RS04975	COG0583	DNA-binding transcription factor activity
C4K15_RS04995	COG4772	TonB-dependent receptor
C4K15_RS05000	COG3712	iron ion homeostasis
C4K15_RS05005	COG1595	DNA-templated transcription, initiation
C4K15_RS05025	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K15_RS05040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K15_RS05045	COG0583	DNA-binding transcription factor activity
C4K15_RS05065	COG1566	PFAM secretion protein HlyD family protein
C4K15_RS05085	COG0300	oxidoreductase activity
C4K15_RS05100	COG2184	nucleotidyltransferase activity
C4K15_RS05110	COG0662	Cupin 2, conserved barrel domain protein
C4K15_RS05110	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4K15_RS05125	COG1696	Membrane protein involved in D-alanine export
C4K15_RS05140	COG3420	alginic acid biosynthetic process
C4K15_RS05150	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4K15_RS05155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS05160	COG1215	transferase activity, transferring glycosyl groups
C4K15_RS05170	COG3022	response to hydroperoxide
C4K15_RS05180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4K15_RS05185	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K15_RS05190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K15_RS05200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS05220	COG0513	Belongs to the DEAD box helicase family
C4K15_RS05230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS05235	COG4597	amino acid ABC transporter
C4K15_RS05240	COG0765	amino acid transport
C4K15_RS05245	COG1126	abc transporter atp-binding protein
C4K15_RS05250	COG2944	sequence-specific DNA binding
C4K15_RS05260	COG2186	Transcriptional regulator
C4K15_RS05265	COG2807	transmembrane transport
C4K15_RS05275	COG2827	Endonuclease containing a URI domain
C4K15_RS05290	COG3081	Nucleoid-associated protein
C4K15_RS05300	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4K15_RS05305	COG0525	valine-tRNA ligase activity
C4K15_RS05320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4K15_RS05325	COG0795	lipopolysaccharide-transporting ATPase activity
C4K15_RS05330	COG0795	lipopolysaccharide-transporting ATPase activity
C4K15_RS05335	COG0481	GTPase activity
C4K15_RS05340	COG0681	Belongs to the peptidase S26 family
C4K15_RS05350	COG0571	ribonuclease III activity
C4K15_RS05355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4K15_RS05360	COG1381	Involved in DNA repair and RecF pathway recombination
C4K15_RS05365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4K15_RS05370	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K15_RS05375	COG0047	phosphoribosylformylglycinamidine synthase activity
C4K15_RS05375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4K15_RS05385	COG1263	PTS System
C4K15_RS05385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K15_RS05385	COG2190	(PTS) system
C4K15_RS05390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K15_RS05390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K15_RS05395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K15_RS05400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4K15_RS05405	COG2188	Transcriptional regulator
C4K15_RS05420	COG0494	nUDIX hydrolase
C4K15_RS05440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4K15_RS05445	COG0477	Major facilitator Superfamily
C4K15_RS05450	COG4536	flavin adenine dinucleotide binding
C4K15_RS05460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4K15_RS05465	COG0228	four-way junction DNA binding
C4K15_RS05470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4K15_RS05475	COG0336	Belongs to the RNA methyltransferase TrmD family
C4K15_RS05480	COG0335	large ribosomal subunit rRNA binding
C4K15_RS05485	COG1607	acyl-coa hydrolase
C4K15_RS05495	COG4974	Belongs to the 'phage' integrase family
C4K15_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS05515	COG2205	protein histidine kinase activity
C4K15_RS05525	COG2197	response regulator
C4K15_RS05545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K15_RS05560	COG1902	pentaerythritol trinitrate reductase activity
C4K15_RS05565	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K15_RS05595	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS05600	COG1177	transmembrane transport
C4K15_RS05605	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K15_RS05610	COG3842	ATPase activity
C4K15_RS05615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K15_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS05625	COG0583	DNA-binding transcription factor activity
C4K15_RS05645	COG0457	Tetratricopeptide repeat
C4K15_RS05645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K15_RS05660	COG2201	protein-glutamate methylesterase activity
C4K15_RS05665	COG5001	Diguanylate cyclase
C4K15_RS05665	COG4251	negative regulation of phosphorylation
C4K15_RS05665	COG3706	GGDEF domain
C4K15_RS05665	COG2203	Gaf domain
C4K15_RS05675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4K15_RS05695	COG1073	alpha beta
C4K15_RS05720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4K15_RS05725	COG0563	adenylate kinase activity
C4K15_RS05730	COG1214	PFAM Peptidase M22, glycoprotease
C4K15_RS05740	COG1801	Protein of unknown function DUF72
C4K15_RS05755	COG0742	ribosomal rna small subunit methyltransferase
C4K15_RS05765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS05785	COG2937	Belongs to the GPAT DAPAT family
C4K15_RS05800	COG2226	methyltransferase
C4K15_RS05805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K15_RS05815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4K15_RS05825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K15_RS05830	COG2171	N-acyltransferase activity
C4K15_RS05835	COG1393	Belongs to the ArsC family
C4K15_RS05840	COG0025	NhaP-type Na H and K H
C4K15_RS05845	COG0436	Aminotransferase
C4K15_RS05850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4K15_RS05855	COG0024	Methionine aminopeptidase
C4K15_RS05860	COG0052	Belongs to the universal ribosomal protein uS2 family
C4K15_RS05865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4K15_RS05870	COG0528	UMP kinase activity
C4K15_RS05875	COG0233	cytoplasmic translational termination
C4K15_RS05880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4K15_RS05890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4K15_RS05910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K15_RS05915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K15_RS05920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K15_RS05925	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K15_RS05930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4K15_RS05935	COG0587	DNA-directed DNA polymerase activity
C4K15_RS05940	COG0825	malonyl-CoA metabolic process
C4K15_RS05945	COG0037	tRNA processing
C4K15_RS05950	COG0504	CTP synthase activity
C4K15_RS05955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4K15_RS05960	COG0148	phosphopyruvate hydratase activity
C4K15_RS05970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4K15_RS05980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4K15_RS05985	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4K15_RS05990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4K15_RS05995	COG0585	pseudouridine synthase activity
C4K15_RS06000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K15_RS06005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4K15_RS06025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4K15_RS06050	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K15_RS06140	COG4386	tail sheath protein
C4K15_RS06175	COG4381	Mu-like prophage protein gp46
C4K15_RS06220	COG3179	chitinase
C4K15_RS06230	COG1546	Belongs to the CinA family
C4K15_RS06235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4K15_RS06240	COG2137	regulation of response to DNA damage stimulus
C4K15_RS06260	COG3148	PFAM DTW domain containing protein
C4K15_RS06275	COG0583	DNA-binding transcription factor activity
C4K15_RS06295	COG4807	Protein conserved in bacteria
C4K15_RS06300	COG1187	pseudouridine synthase activity
C4K15_RS06310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K15_RS06320	COG3158	transport of potassium into the cell
C4K15_RS06330	COG0392	lysyltransferase activity
C4K15_RS06330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4K15_RS06345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4K15_RS06355	COG0442	prolyl-tRNA aminoacylation
C4K15_RS06380	COG1278	Cold shock
C4K15_RS06385	COG0717	Belongs to the dCTP deaminase family
C4K15_RS06410	COG4215	(ABC) transporter
C4K15_RS06420	COG2366	antibiotic biosynthetic process
C4K15_RS06425	COG0625	glutathione transferase activity
C4K15_RS06435	COG0653	protein targeting
C4K15_RS06445	COG3012	SEC-C Motif Domain Protein
C4K15_RS06480	COG1199	ATP-dependent helicase activity
C4K15_RS06495	COG2885	chlorophyll binding
C4K15_RS06500	COG0259	pyridoxamine-phosphate oxidase activity
C4K15_RS06515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K15_RS06525	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4K15_RS06540	COG0583	DNA-binding transcription factor activity
C4K15_RS06555	COG3220	belongs to the UPF0276 family
C4K15_RS06600	COG2084	Dehydrogenase
C4K15_RS06610	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4K15_RS06615	COG2271	Major facilitator Superfamily
C4K15_RS06620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K15_RS06630	COG0306	phosphate transporter
C4K15_RS06640	COG1414	Transcriptional regulator
C4K15_RS06645	COG2814	Major facilitator Superfamily
C4K15_RS06650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K15_RS06655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4K15_RS06660	COG0183	Belongs to the thiolase family
C4K15_RS06665	COG3485	protocatechuate 3,4-dioxygenase
C4K15_RS06670	COG3485	protocatechuate 3,4-dioxygenase
C4K15_RS06675	COG0477	Major facilitator Superfamily
C4K15_RS06685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K15_RS06690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K15_RS06710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS06725	COG1902	pentaerythritol trinitrate reductase activity
C4K15_RS06730	COG2814	Major facilitator Superfamily
C4K15_RS06770	COG1473	amidohydrolase
C4K15_RS06780	COG0154	amidase activity
C4K15_RS06805	COG1704	LemA family
C4K15_RS06810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4K15_RS06825	COG0697	spore germination
C4K15_RS06830	COG0693	protein deglycase activity
C4K15_RS06845	COG1629	transport
C4K15_RS06855	COG1595	DNA-templated transcription, initiation
C4K15_RS06860	COG3422	double-strand break repair
C4K15_RS06865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K15_RS06870	COG0235	Class ii aldolase
C4K15_RS06875	COG1396	sequence-specific DNA binding
C4K15_RS06885	COG1454	alcohol dehydrogenase
C4K15_RS06890	COG1309	transcriptional regulator
C4K15_RS06900	COG3668	Plasmid stabilization system
C4K15_RS06970	COG3938	Belongs to the proline racemase family
C4K15_RS06975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K15_RS06980	COG0531	amino acid
C4K15_RS06990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4K15_RS07010	COG0583	DNA-binding transcription factor activity
C4K15_RS07015	COG5001	Diguanylate cyclase
C4K15_RS07025	COG3468	outer membrane autotransporter barrel domain protein
C4K15_RS07035	COG2267	carboxylic ester hydrolase activity
C4K15_RS07050	COG3706	GGDEF domain
C4K15_RS07065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4K15_RS07115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4K15_RS07150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K15_RS07160	COG0425	Belongs to the sulfur carrier protein TusA family
C4K15_RS07170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4K15_RS07185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K15_RS07190	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4K15_RS07195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K15_RS07200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4K15_RS07220	COG2197	response regulator
C4K15_RS07230	COG3121	Chaperone
C4K15_RS07235	COG3188	usher protein
C4K15_RS07240	COG3121	Chaperone
C4K15_RS07245	COG2831	hemolysin activation secretion protein
C4K15_RS07280	COG2807	transmembrane transport
C4K15_RS07285	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4K15_RS07295	COG0583	DNA-binding transcription factor activity
C4K15_RS07305	COG2194	sulfuric ester hydrolase activity
C4K15_RS07320	COG3100	YcgL domain-containing protein
C4K15_RS07325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K15_RS07335	COG2983	Belongs to the UPF0260 family
C4K15_RS07385	COG0121	glutamine amidotransferase
C4K15_RS07395	COG0583	DNA-binding transcription factor activity
C4K15_RS07400	COG2814	Major facilitator Superfamily
C4K15_RS07405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K15_RS07410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K15_RS07415	COG1984	allophanate hydrolase subunit 2
C4K15_RS07425	COG0542	response to heat
C4K15_RS07435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K15_RS07465	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4K15_RS07470	COG1643	Atp-dependent helicase
C4K15_RS07480	COG1595	DNA-templated transcription, initiation
C4K15_RS07510	COG0814	amino acid
C4K15_RS07530	COG4638	Rieske (2fe-2S)
C4K15_RS07545	COG0477	Major facilitator Superfamily
C4K15_RS07550	COG0583	DNA-binding transcription factor activity
C4K15_RS07560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4K15_RS07565	COG1132	(ABC) transporter
C4K15_RS07575	COG2267	carboxylic ester hydrolase activity
C4K15_RS07590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K15_RS07600	COG0668	transmembrane transport
C4K15_RS07605	COG0513	Belongs to the DEAD box helicase family
C4K15_RS07635	COG3039	Transposase
C4K15_RS07695	COG1953	Uracil, thiamine, allantoin
C4K15_RS07700	COG0697	spore germination
C4K15_RS07710	COG0583	DNA-binding transcription factor activity
C4K15_RS07720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K15_RS07725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K15_RS07755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS07775	COG5001	Diguanylate cyclase
C4K15_RS07775	COG3300	MHYT domain
C4K15_RS07785	COG2832	Protein of unknown function (DUF454)
C4K15_RS07810	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4K15_RS07825	COG2207	Transcriptional regulator
C4K15_RS07850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4K15_RS07875	COG0745	RESPONSE REGULATOR receiver
C4K15_RS07885	COG2350	Protein conserved in bacteria
C4K15_RS07890	COG2917	probably involved in intracellular septation
C4K15_RS07895	COG0613	PHP domain protein
C4K15_RS07900	COG0009	L-threonylcarbamoyladenylate synthase
C4K15_RS07910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4K15_RS07930	COG1113	amino acid transport
C4K15_RS07955	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4K15_RS07970	COG4786	Flagellar basal body rod
C4K15_RS07980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4K15_RS07985	COG1706	bacterial-type flagellum-dependent cell motility
C4K15_RS07995	COG1256	bacterial-type flagellum assembly
C4K15_RS08005	COG0438	transferase activity, transferring glycosyl groups
C4K15_RS08005	COG1216	Glycosyl transferase, family 2
C4K15_RS08010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K15_RS08020	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4K15_RS08045	COG0438	transferase activity, transferring glycosyl groups
C4K15_RS08045	COG1216	Glycosyl transferase, family 2
C4K15_RS08050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K15_RS08055	COG1083	cytidylyl-transferase
C4K15_RS08065	COG2089	acid synthase
C4K15_RS08085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4K15_RS08125	COG1677	Flagellar hook-basal body complex protein FliE
C4K15_RS08160	COG0745	RESPONSE REGULATOR receiver
C4K15_RS08240	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4K15_RS08245	COG0643	Histidine kinase
C4K15_RS08245	COG0784	Response regulator, receiver
C4K15_RS08245	COG2198	Histidine kinase
C4K15_RS08250	COG2201	protein-glutamate methylesterase activity
C4K15_RS08255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4K15_RS08265	COG1192	Involved in chromosome partitioning
C4K15_RS08275	COG0835	chemotaxis
C4K15_RS08295	COG4133	protoheme IX ABC transporter activity
C4K15_RS08315	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4K15_RS08320	COG1138	Cytochrome C-type biogenesis protein
C4K15_RS08330	COG3088	subunit of a heme lyase
C4K15_RS08350	COG0583	DNA-binding transcription factor activity
C4K15_RS08355	COG2814	Major facilitator Superfamily
C4K15_RS08375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K15_RS08380	COG4413	Urea transporter
C4K15_RS08385	COG0469	pyruvate kinase activity
C4K15_RS08395	COG2084	Dehydrogenase
C4K15_RS08400	COG3622	Belongs to the hyi family
C4K15_RS08405	COG3960	tartronate-semialdehyde synthase activity
C4K15_RS08415	COG1309	transcriptional regulator
C4K15_RS08420	COG2354	Protein conserved in bacteria
C4K15_RS08425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K15_RS08440	COG1834	amidinotransferase
C4K15_RS08450	COG2192	nodulation
C4K15_RS08455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K15_RS08460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS08480	COG2853	Lipoprotein
C4K15_RS08500	COG2113	Glycine betaine
C4K15_RS08505	COG3162	membrane
C4K15_RS08510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K15_RS08520	COG2009	succinate dehydrogenase
C4K15_RS08525	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4K15_RS08530	COG1053	succinate dehydrogenase
C4K15_RS08550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K15_RS08555	COG0045	succinate-CoA ligase (ADP-forming) activity
C4K15_RS08595	COG0326	Molecular chaperone. Has ATPase activity
C4K15_RS08605	COG0626	cystathionine gamma-synthase activity
C4K15_RS08615	COG1741	Belongs to the pirin family
C4K15_RS08640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K15_RS08645	COG2205	protein histidine kinase activity
C4K15_RS08645	COG0784	Response regulator, receiver
C4K15_RS08645	COG5002	protein histidine kinase activity
C4K15_RS08655	COG4771	TonB-dependent receptor
C4K15_RS08660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4K15_RS08670	COG2062	phosphohistidine phosphatase, SixA
C4K15_RS08675	COG1022	Amp-dependent synthetase and ligase
C4K15_RS08695	COG0625	glutathione transferase activity
C4K15_RS08705	COG0628	permease
C4K15_RS08720	COG0284	orotidine-5'-phosphate decarboxylase activity
C4K15_RS08725	COG2130	NADP-dependent
C4K15_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS08735	COG0840	transmembrane signaling receptor activity
C4K15_RS08765	COG2814	Major facilitator Superfamily
C4K15_RS08785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS08785	COG2205	protein histidine kinase activity
C4K15_RS08805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K15_RS08820	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS08830	COG0625	glutathione transferase activity
C4K15_RS08835	COG1131	(ABC) transporter
C4K15_RS08840	COG0842	Transport permease protein
C4K15_RS08855	COG0811	peptide transport
C4K15_RS08860	COG0848	biopolymer transport protein
C4K15_RS08865	COG1663	tetraacyldisaccharide 4'-kinase activity
C4K15_RS08870	COG2835	tetraacyldisaccharide 4'-kinase activity
C4K15_RS08875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K15_RS08880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K15_RS08885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4K15_RS08895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K15_RS08900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4K15_RS08900	COG3608	succinylglutamate desuccinylase aspartoacylase
C4K15_RS08910	COG1530	ribonuclease E activity
C4K15_RS08920	COG0546	phosphoglycolate phosphatase activity
C4K15_RS08925	COG0616	signal peptide processing
C4K15_RS08925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K15_RS08930	COG0424	maF-like protein
C4K15_RS08940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4K15_RS08945	COG0416	fatty acid biosynthetic process
C4K15_RS08960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K15_RS08965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K15_RS08975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4K15_RS08980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4K15_RS08990	COG0084	hydrolase, TatD family'
C4K15_RS09005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K15_RS09020	COG2188	Transcriptional regulator
C4K15_RS09025	COG1397	ADP-ribosylglycohydrolase
C4K15_RS09035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K15_RS09065	COG1418	mRNA catabolic process
C4K15_RS09075	COG3734	2-keto-3-deoxy-galactonokinase
C4K15_RS09080	COG0800	Aldolase
C4K15_RS09085	COG4948	Mandelate Racemase Muconate Lactonizing
C4K15_RS09090	COG2271	Major facilitator Superfamily
C4K15_RS09095	COG1414	Transcriptional regulator
C4K15_RS09100	COG1064	alcohol dehydrogenase
C4K15_RS09105	COG2207	Transcriptional regulator
C4K15_RS09110	COG3385	transposase activity
C4K15_RS09140	COG2885	chlorophyll binding
C4K15_RS09140	COG3047	cAMP biosynthetic process
C4K15_RS09145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K15_RS09180	COG0183	Belongs to the thiolase family
C4K15_RS09185	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS09185	COG1024	Enoyl-CoA hydratase
C4K15_RS09190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K15_RS09190	COG0519	Catalyzes the synthesis of GMP from XMP
C4K15_RS09195	COG0598	Magnesium transport protein CorA
C4K15_RS09200	COG0204	Acyl-transferase
C4K15_RS09250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K15_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS09260	COG0583	DNA-binding transcription factor activity
C4K15_RS09270	COG1953	Uracil, thiamine, allantoin
C4K15_RS09280	COG0560	Phosphoserine phosphatase
C4K15_RS09300	COG4067	protein conserved in archaea
C4K15_RS09300	COG0189	ligase activity
C4K15_RS09305	COG1802	Transcriptional regulator
C4K15_RS09315	COG0372	Belongs to the citrate synthase family
C4K15_RS09330	COG2079	MmgE PrpD family protein
C4K15_RS09335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4K15_RS09350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K15_RS09365	COG0668	transmembrane transport
C4K15_RS09375	COG3047	cAMP biosynthetic process
C4K15_RS09375	COG2885	chlorophyll binding
C4K15_RS09380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K15_RS09385	COG0243	molybdopterin cofactor binding
C4K15_RS09390	COG2146	nitrite reductase [NAD(P)H] activity
C4K15_RS09395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K15_RS09400	COG0515	serine threonine protein kinase
C4K15_RS09400	COG2815	serine threonine protein kinase
C4K15_RS09405	COG2223	nitrite transmembrane transporter activity
C4K15_RS09410	COG3707	response regulator
C4K15_RS09415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS09420	COG0167	dihydroorotate dehydrogenase activity
C4K15_RS09425	COG3130	regulation of translation
C4K15_RS09430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K15_RS09430	COG0116	Belongs to the methyltransferase superfamily
C4K15_RS09440	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K15_RS09470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS09475	COG1538	Outer membrane efflux protein
C4K15_RS09490	COG2197	response regulator
C4K15_RS09495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS09495	COG2205	protein histidine kinase activity
C4K15_RS09500	COG5001	Diguanylate cyclase
C4K15_RS09500	COG3300	MHYT domain
C4K15_RS09510	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K15_RS09520	COG3152	Membrane
C4K15_RS09565	COG3171	Protein conserved in bacteria
C4K15_RS09595	COG3135	benzoate transporter
C4K15_RS09600	COG1802	Transcriptional regulator
C4K15_RS09605	COG0402	S-adenosylhomocysteine deaminase activity
C4K15_RS09630	COG1196	nuclear chromosome segregation
C4K15_RS09635	COG3115	cell septum assembly
C4K15_RS09640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K15_RS09700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4K15_RS09705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4K15_RS09710	COG2130	NADP-dependent
C4K15_RS09715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4K15_RS09720	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS09725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K15_RS09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K15_RS09750	COG2217	Heavy metal translocating P-type atpase
C4K15_RS09760	COG0348	domain, Protein
C4K15_RS09775	COG2010	Cytochrome c
C4K15_RS09790	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K15_RS09795	COG2010	Cytochrome c
C4K15_RS09810	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K15_RS09820	COG0840	transmembrane signaling receptor activity
C4K15_RS09835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4K15_RS09840	COG0425	Belongs to the sulfur carrier protein TusA family
C4K15_RS09850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K15_RS09860	COG1132	(ABC) transporter
C4K15_RS09865	COG0741	lytic transglycosylase activity
C4K15_RS09870	COG0488	(ABC) transporter
C4K15_RS09875	COG0589	response to stress
C4K15_RS09890	COG1024	Enoyl-CoA hydratase
C4K15_RS09890	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS09895	COG0183	Belongs to the thiolase family
C4K15_RS09940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K15_RS09945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K15_RS09955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4K15_RS09970	COG1477	protein flavinylation
C4K15_RS09975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K15_RS09980	COG0584	glycerophosphoryl diester phosphodiesterase
C4K15_RS09990	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K15_RS09995	COG1136	(ABC) transporter
C4K15_RS10000	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K15_RS10020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K15_RS10020	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K15_RS10030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K15_RS10035	COG2853	Lipoprotein
C4K15_RS10050	COG2204	response regulator
C4K15_RS10060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4K15_RS10065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K15_RS10070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K15_RS10075	COG0583	DNA-binding transcription factor activity
C4K15_RS10085	COG5001	Diguanylate cyclase
C4K15_RS10085	COG4251	negative regulation of phosphorylation
C4K15_RS10085	COG3706	GGDEF domain
C4K15_RS10085	COG2203	Gaf domain
C4K15_RS10110	COG2233	PERMEase
C4K15_RS10140	COG0556	nucleotide-excision repair
C4K15_RS10155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K15_RS10185	COG0596	Alpha beta hydrolase
C4K15_RS10195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K15_RS10210	COG2214	Heat shock protein DnaJ domain protein
C4K15_RS10215	COG0443	Heat shock 70 kDa protein
C4K15_RS10230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4K15_RS10235	COG0066	3-isopropylmalate dehydratase activity
C4K15_RS10240	COG0473	3-isopropylmalate dehydrogenase activity
C4K15_RS10270	COG0135	phosphoribosylanthranilate isomerase activity
C4K15_RS10275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4K15_RS10280	COG0285	dihydrofolate synthase activity
C4K15_RS10285	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K15_RS10290	COG1286	toxin biosynthetic process
C4K15_RS10325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS10355	COG3397	chitin binding
C4K15_RS10360	COG3469	chitinase activity
C4K15_RS10375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K15_RS10410	COG1129	ABC transporter
C4K15_RS10415	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K15_RS10420	COG1609	Transcriptional regulator
C4K15_RS10425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K15_RS10430	COG1869	D-ribose catabolic process
C4K15_RS10455	COG1278	Cold shock
C4K15_RS10465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K15_RS10470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4K15_RS10475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4K15_RS10480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4K15_RS10485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4K15_RS10490	COG0072	phenylalanine-tRNA ligase activity
C4K15_RS10495	COG0776	regulation of translation
C4K15_RS10540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K15_RS10540	COG2755	lipolytic protein G-D-S-L family
C4K15_RS10585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K15_RS10620	COG1309	transcriptional regulator
C4K15_RS10625	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS10635	COG3284	Transcriptional regulator
C4K15_RS10640	COG3199	ATP-NAD kinase
C4K15_RS10645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K15_RS10650	COG0022	dehydrogenase e1 component
C4K15_RS10660	COG1063	alcohol dehydrogenase
C4K15_RS10675	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS10680	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS10685	COG4191	Histidine kinase
C4K15_RS10690	COG4566	intracellular signal transduction
C4K15_RS10700	COG1598	PFAM Uncharacterised protein family UPF0150
C4K15_RS10745	COG0450	alkyl hydroperoxide reductase
C4K15_RS10780	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K15_RS10785	COG3657	addiction module killer protein
C4K15_RS10790	COG5383	Protein conserved in bacteria
C4K15_RS10795	COG3706	GGDEF domain
C4K15_RS10820	COG0531	amino acid
C4K15_RS10830	COG0174	glutamine synthetase
C4K15_RS10835	COG1335	isochorismatase
C4K15_RS10845	COG0583	DNA-binding transcription factor activity
C4K15_RS10905	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4K15_RS10910	COG0247	lactate metabolic process
C4K15_RS10915	COG0277	FAD linked oxidase domain protein
C4K15_RS10920	COG0277	FAD linked oxidase domain protein
C4K15_RS10925	COG2186	Transcriptional regulator
C4K15_RS10955	COG1063	alcohol dehydrogenase
C4K15_RS10975	COG0709	Synthesizes selenophosphate from selenide and ATP
C4K15_RS10980	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4K15_RS10985	COG0701	Predicted permease
C4K15_RS10990	COG1414	Transcriptional regulator
C4K15_RS10995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS11000	COG0765	amino acid transport
C4K15_RS11005	COG1126	abc transporter atp-binding protein
C4K15_RS11010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS11020	COG0625	glutathione transferase activity
C4K15_RS11025	COG0384	phenazine biosynthesis protein PhzF
C4K15_RS11040	COG0248	Ppx GppA phosphatase
C4K15_RS11045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K15_RS11065	COG0019	diaminopimelate decarboxylase activity
C4K15_RS11080	COG0071	Belongs to the small heat shock protein (HSP20) family
C4K15_RS11085	COG0113	porphobilinogen synthase activity
C4K15_RS11115	COG4172	Belongs to the ABC transporter superfamily
C4K15_RS11120	COG4239	(ABC) transporter, permease
C4K15_RS11125	COG4174	ABC transporter (Permease)
C4K15_RS11130	COG4166	transmembrane transport
C4K15_RS11165	COG4650	regulator
C4K15_RS11175	COG1690	Belongs to the RtcB family
C4K15_RS11185	COG3541	Predicted nucleotidyltransferase
C4K15_RS11190	COG0430	RNA-3'-phosphate cyclase activity
C4K15_RS11220	COG0583	DNA-binding transcription factor activity
C4K15_RS11245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K15_RS11250	COG0583	DNA-binding transcription factor activity
C4K15_RS11255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K15_RS11265	COG3180	Ammonia monooxygenase
C4K15_RS11270	COG0583	DNA-binding transcription factor activity
C4K15_RS11275	COG0517	IMP dehydrogenase activity
C4K15_RS11295	COG1177	transmembrane transport
C4K15_RS11300	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K15_RS11305	COG3842	ATPase activity
C4K15_RS11310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K15_RS11320	COG0174	glutamine synthetase
C4K15_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS11330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS11335	COG1917	Cupin 2, conserved barrel domain protein
C4K15_RS11335	COG1396	sequence-specific DNA binding
C4K15_RS11410	COG1595	DNA-templated transcription, initiation
C4K15_RS11415	COG3712	iron ion homeostasis
C4K15_RS11420	COG4772	TonB-dependent receptor
C4K15_RS11425	COG1944	ATP diphosphatase activity
C4K15_RS11475	COG2223	nitrite transmembrane transporter activity
C4K15_RS11495	COG0697	spore germination
C4K15_RS11500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K15_RS11510	COG0659	secondary active sulfate transmembrane transporter activity
C4K15_RS11520	COG1999	signal sequence binding
C4K15_RS11535	COG0583	DNA-binding transcription factor activity
C4K15_RS11540	COG3048	D-serine ammonia-lyase activity
C4K15_RS11545	COG2610	gluconate transmembrane transporter activity
C4K15_RS11550	COG0251	oxidation-reduction process
C4K15_RS11560	COG0688	phosphatidylethanolamine metabolic process
C4K15_RS11575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K15_RS11590	COG0477	Major facilitator Superfamily
C4K15_RS11595	COG0346	lactoylglutathione lyase activity
C4K15_RS11605	COG0826	peptidase U32
C4K15_RS11620	COG2207	Transcriptional regulator
C4K15_RS11675	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K15_RS11685	COG1611	Belongs to the LOG family
C4K15_RS11700	COG2204	response regulator
C4K15_RS11705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4K15_RS11715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K15_RS11730	COG0494	nUDIX hydrolase
C4K15_RS11765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS11770	COG0174	glutamine synthetase
C4K15_RS11785	COG1335	isochorismatase
C4K15_RS11790	COG3224	Antibiotic biosynthesis monooxygenase
C4K15_RS11795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K15_RS11810	COG0417	DNA replication proofreading
C4K15_RS11820	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K15_RS11835	COG0477	Major facilitator Superfamily
C4K15_RS11855	COG4319	ketosteroid isomerase
C4K15_RS11860	COG4335	DNA alkylation repair
C4K15_RS11875	COG0583	DNA-binding transcription factor activity
C4K15_RS11880	COG2828	Protein conserved in bacteria
C4K15_RS11885	COG1301	dicarboxylic acid transport
C4K15_RS11890	COG2851	Citrate transporter
C4K15_RS11905	COG1704	LemA family
C4K15_RS11910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K15_RS11935	COG1230	cation diffusion facilitator family transporter
C4K15_RS11940	COG2267	carboxylic ester hydrolase activity
C4K15_RS11950	COG2124	cytochrome p450
C4K15_RS11955	COG0640	Transcriptional regulator
C4K15_RS11970	COG2308	Evidence 4 Homologs of previously reported genes of
C4K15_RS11980	COG1305	Transglutaminase-like
C4K15_RS11985	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K15_RS11990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4K15_RS11995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K15_RS12005	COG0022	dehydrogenase e1 component
C4K15_RS12010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K15_RS12015	COG1522	sequence-specific DNA binding
C4K15_RS12025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K15_RS12055	COG1309	transcriptional regulator
C4K15_RS12065	COG0493	'glutamate synthase
C4K15_RS12075	COG1953	Uracil, thiamine, allantoin
C4K15_RS12090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS12095	COG0517	IMP dehydrogenase activity
C4K15_RS12095	COG4175	Glycine betaine
C4K15_RS12105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K15_RS12120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS12135	COG0495	leucyl-tRNA aminoacylation
C4K15_RS12195	COG1595	DNA-templated transcription, initiation
C4K15_RS12205	COG3727	T/G mismatch-specific endonuclease activity
C4K15_RS12220	COG0270	DNA (cytosine-5-)-methyltransferase activity
C4K15_RS12285	COG2391	methyltransferase activity
C4K15_RS12320	COG2204	response regulator
C4K15_RS12350	COG0745	RESPONSE REGULATOR receiver
C4K15_RS12365	COG3383	formate dehydrogenase (NAD+) activity
C4K15_RS12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K15_RS12375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS12410	COG3718	enzyme involved in inositol metabolism
C4K15_RS12425	COG3962	Belongs to the TPP enzyme family
C4K15_RS12430	COG0673	inositol 2-dehydrogenase activity
C4K15_RS12435	COG1082	Xylose isomerase domain protein TIM barrel
C4K15_RS12440	COG0673	inositol 2-dehydrogenase activity
C4K15_RS12455	COG1129	ABC transporter
C4K15_RS12460	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4K15_RS12510	COG4774	siderophore transport
C4K15_RS12525	COG1320	monovalent cation:proton antiporter activity
C4K15_RS12530	COG2212	antiporter activity
C4K15_RS12540	COG0651	ATP synthesis coupled electron transport
C4K15_RS12545	COG1006	Multisubunit Na H antiporter MnhC subunit
C4K15_RS12550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4K15_RS12550	COG2111	Na H antiporter
C4K15_RS12615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K15_RS12620	COG0673	inositol 2-dehydrogenase activity
C4K15_RS12630	COG3385	transposase activity
C4K15_RS12635	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS12645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K15_RS12650	COG1335	isochorismatase
C4K15_RS12665	COG3383	formate dehydrogenase (NAD+) activity
C4K15_RS12675	COG0814	amino acid
C4K15_RS12705	COG0589	response to stress
C4K15_RS12715	COG0745	RESPONSE REGULATOR receiver
C4K15_RS12720	COG2205	protein histidine kinase activity
C4K15_RS12735	COG3791	Glutathione-dependent formaldehyde-activating
C4K15_RS12750	COG0583	DNA-binding transcription factor activity
C4K15_RS12755	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4K15_RS12760	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS12765	COG2079	MmgE PrpD family protein
C4K15_RS12810	COG0583	DNA-binding transcription factor activity
C4K15_RS12830	COG0431	NADPH-dependent FMN reductase
C4K15_RS12890	COG2271	Major facilitator Superfamily
C4K15_RS12895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K15_RS12930	COG0583	DNA-binding transcription factor activity
C4K15_RS12940	COG1942	4-Oxalocrotonate Tautomerase
C4K15_RS12970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K15_RS12985	COG0673	inositol 2-dehydrogenase activity
C4K15_RS12995	COG1609	Transcriptional regulator
C4K15_RS13055	COG0596	Alpha beta hydrolase
C4K15_RS13060	COG2384	SAM-dependent methyltransferase
C4K15_RS13065	COG0789	Transcriptional regulator
C4K15_RS13135	COG2080	2 iron, 2 sulfur cluster binding
C4K15_RS13140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4K15_RS13145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K15_RS13150	COG1280	lysine exporter protein (LysE YggA)
C4K15_RS13185	COG1280	lysine exporter protein (LysE YggA)
C4K15_RS13195	COG1566	PFAM secretion protein HlyD family protein
C4K15_RS13205	COG2828	Protein conserved in bacteria
C4K15_RS13210	COG2207	Transcriptional regulator
C4K15_RS13225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4K15_RS13265	COG2084	Dehydrogenase
C4K15_RS13270	COG3395	kinase activity
C4K15_RS13275	COG0235	Class ii aldolase
C4K15_RS13280	COG2610	gluconate transmembrane transporter activity
C4K15_RS13285	COG3622	Belongs to the hyi family
C4K15_RS13295	COG1349	DNA-binding transcription factor activity
C4K15_RS13375	COG1902	pentaerythritol trinitrate reductase activity
C4K15_RS13380	COG4221	oxidoreductase activity
C4K15_RS13385	COG2267	carboxylic ester hydrolase activity
C4K15_RS13390	COG3321	synthase
C4K15_RS13390	COG0604	alcohol dehydrogenase
C4K15_RS13395	COG2200	EAL domain
C4K15_RS13395	COG2202	Pas domain
C4K15_RS13395	COG2199	diguanylate cyclase activity
C4K15_RS13400	COG0833	amino acid
C4K15_RS13405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS13410	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4K15_RS13425	COG0494	nUDIX hydrolase
C4K15_RS13435	COG3220	belongs to the UPF0276 family
C4K15_RS13445	COG2259	Doxx family
C4K15_RS13455	COG2205	protein histidine kinase activity
C4K15_RS13510	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K15_RS13530	COG0754	glutathionylspermidine amidase activity
C4K15_RS13540	COG3766	membrane
C4K15_RS13560	COG1842	Phage shock protein A
C4K15_RS13595	COG0583	DNA-binding transcription factor activity
C4K15_RS13600	COG0300	oxidoreductase activity
C4K15_RS13625	COG4172	Belongs to the ABC transporter superfamily
C4K15_RS13630	COG4239	(ABC) transporter, permease
C4K15_RS13635	COG4174	ABC transporter (Permease)
C4K15_RS13640	COG4166	transmembrane transport
C4K15_RS13645	COG4166	transmembrane transport
C4K15_RS13650	COG1388	LysM domain
C4K15_RS13650	COG0741	lytic transglycosylase activity
C4K15_RS13655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K15_RS13665	COG0328	RNA-DNA hybrid ribonuclease activity
C4K15_RS13680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K15_RS13705	COG0431	NADPH-dependent FMN reductase
C4K15_RS13710	COG0640	Transcriptional regulator
C4K15_RS13725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4K15_RS13730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K15_RS13740	COG3139	Protein of unknown function (DUF1315)
C4K15_RS13750	COG0308	aminopeptidase N
C4K15_RS13755	COG0659	secondary active sulfate transmembrane transporter activity
C4K15_RS13775	COG2706	6-phosphogluconolactonase activity
C4K15_RS13805	COG0420	3'-5' exonuclease activity
C4K15_RS13850	COG0714	Associated with various cellular activities
C4K15_RS13855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS13860	COG0477	Major facilitator Superfamily
C4K15_RS13865	COG0579	oxidoreductase
C4K15_RS13870	COG2186	Transcriptional regulator
C4K15_RS13900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K15_RS14070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K15_RS14090	COG1794	racemase activity, acting on amino acids and derivatives
C4K15_RS14125	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K15_RS14135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K15_RS14170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K15_RS14175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K15_RS14180	COG1538	Outer membrane efflux protein
C4K15_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS14195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K15_RS14200	COG0348	domain, Protein
C4K15_RS14210	COG1285	pathogenesis
C4K15_RS14230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K15_RS14245	COG3568	Endonuclease Exonuclease Phosphatase
C4K15_RS14300	COG1640	4-alpha-glucanotransferase
C4K15_RS14305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K15_RS14310	COG0297	glycogen (starch) synthase activity
C4K15_RS14315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K15_RS14325	COG1238	metal cluster binding
C4K15_RS14365	COG0667	Aldo Keto reductase
C4K15_RS14370	COG0583	DNA-binding transcription factor activity
C4K15_RS14385	COG2366	antibiotic biosynthetic process
C4K15_RS14425	COG0583	DNA-binding transcription factor activity
C4K15_RS14435	COG1017	nitric oxide dioxygenase activity
C4K15_RS14435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K15_RS14445	COG2066	Belongs to the glutaminase family
C4K15_RS14455	COG2233	PERMEase
C4K15_RS14480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K15_RS14515	COG2194	sulfuric ester hydrolase activity
C4K15_RS14520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4K15_RS14525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4K15_RS14530	COG0561	phosphatase activity
C4K15_RS14535	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K15_RS14540	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS14540	COG2030	dehydratase
C4K15_RS14555	COG3162	membrane
C4K15_RS14560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K15_RS14565	COG2151	metal-sulfur cluster biosynthetic enzyme
C4K15_RS14570	COG3396	Phenylacetate-CoA oxygenase
C4K15_RS14575	COG3460	Phenylacetate-CoA oxygenase
C4K15_RS14580	COG3396	Phenylacetate-CoA oxygenase
C4K15_RS14590	COG0183	Belongs to the thiolase family
C4K15_RS14595	COG2050	protein possibly involved in aromatic compounds catabolism
C4K15_RS14600	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS14605	COG1024	Enoyl-CoA hydratase
C4K15_RS14610	COG1024	Enoyl-CoA hydratase
C4K15_RS14620	COG3327	negative regulation of DNA-templated transcription, initiation
C4K15_RS14640	COG2204	response regulator
C4K15_RS14685	COG0840	transmembrane signaling receptor activity
C4K15_RS14690	COG1968	undecaprenyl-diphosphatase activity
C4K15_RS14710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K15_RS14725	COG0488	(ABC) transporter
C4K15_RS14745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4K15_RS14755	COG2133	pyrroloquinoline quinone binding
C4K15_RS14765	COG0189	ligase activity
C4K15_RS14770	COG0598	Magnesium transport protein CorA
C4K15_RS14775	COG0024	Methionine aminopeptidase
C4K15_RS14790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K15_RS14795	COG4574	serine-type endopeptidase inhibitor activity
C4K15_RS14860	COG0726	polysaccharide deacetylase
C4K15_RS14870	COG0463	Glycosyl transferase, family 2
C4K15_RS14930	COG1070	Carbohydrate kinase
C4K15_RS14950	COG1175	transmembrane transport
C4K15_RS14960	COG4774	siderophore transport
C4K15_RS14965	COG2207	Transcriptional regulator
C4K15_RS14970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K15_RS14980	COG0183	Belongs to the thiolase family
C4K15_RS14985	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS14990	COG1024	Enoyl-CoA hydratase
C4K15_RS14995	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS15000	COG1024	Enoyl-CoA hydratase
C4K15_RS15015	COG2814	Major facilitator Superfamily
C4K15_RS15045	COG0765	amino acid transport
C4K15_RS15050	COG0165	Argininosuccinate lyase
C4K15_RS15075	COG2076	Multidrug Resistance protein
C4K15_RS15080	COG2076	Multidrug Resistance protein
C4K15_RS15085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K15_RS15090	COG0726	polysaccharide deacetylase
C4K15_RS15095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K15_RS15095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS15100	COG0463	Glycosyl transferase, family 2
C4K15_RS15105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K15_RS15120	COG1131	(ABC) transporter
C4K15_RS15155	COG0765	amino acid transport
C4K15_RS15165	COG0405	Gamma-glutamyltransferase
C4K15_RS15195	COG0589	response to stress
C4K15_RS15245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS15250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K15_RS15265	COG1024	Enoyl-CoA hydratase
C4K15_RS15265	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS15300	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS15310	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS15315	COG4221	oxidoreductase activity
C4K15_RS15315	COG0300	oxidoreductase activity
C4K15_RS15315	COG3321	synthase
C4K15_RS15315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K15_RS15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS15325	COG1231	oxidoreductase activity
C4K15_RS15340	COG2863	cytochrome
C4K15_RS15360	COG0251	oxidation-reduction process
C4K15_RS15370	COG0745	RESPONSE REGULATOR receiver
C4K15_RS15420	COG1476	TRANSCRIPTIONal
C4K15_RS15440	COG3039	Transposase
C4K15_RS15445	COG3188	usher protein
C4K15_RS15450	COG3121	Chaperone
C4K15_RS15465	COG2197	response regulator
C4K15_RS15505	COG2205	protein histidine kinase activity
C4K15_RS15505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS15510	COG2197	response regulator
C4K15_RS15515	COG3300	MHYT domain
C4K15_RS15515	COG5001	Diguanylate cyclase
C4K15_RS15565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K15_RS15570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K15_RS15605	COG4608	Belongs to the ABC transporter superfamily
C4K15_RS15610	COG0444	Belongs to the ABC transporter superfamily
C4K15_RS15615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K15_RS15620	COG0601	transmembrane transport
C4K15_RS15625	COG0747	negative chemotaxis
C4K15_RS15630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4K15_RS15645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K15_RS15650	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4K15_RS15655	COG3540	Alkaline phosphatase
C4K15_RS15680	COG0811	peptide transport
C4K15_RS15690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K15_RS15720	COG2084	Dehydrogenase
C4K15_RS15745	COG1116	anion transmembrane transporter activity
C4K15_RS15750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS15755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS15760	COG0235	Class ii aldolase
C4K15_RS15765	COG0583	DNA-binding transcription factor activity
C4K15_RS15785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS15795	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS15845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C4K15_RS15870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K15_RS15875	COG0475	glutathione-regulated potassium exporter activity
C4K15_RS15905	COG3264	Mechanosensitive ion channel
C4K15_RS15905	COG1196	nuclear chromosome segregation
C4K15_RS15910	COG3706	GGDEF domain
C4K15_RS15915	COG0583	DNA-binding transcription factor activity
C4K15_RS15920	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS15925	COG3385	transposase activity
C4K15_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS15935	COG2323	membrane
C4K15_RS15945	COG1058	Belongs to the CinA family
C4K15_RS15945	COG1546	Belongs to the CinA family
C4K15_RS16005	COG0247	lactate metabolic process
C4K15_RS16005	COG0277	FAD linked oxidase domain protein
C4K15_RS16010	COG0583	DNA-binding transcription factor activity
C4K15_RS16025	COG4104	PAAR repeat-containing protein
C4K15_RS16060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K15_RS16060	COG2146	nitrite reductase [NAD(P)H] activity
C4K15_RS16065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K15_RS16065	COG2146	nitrite reductase [NAD(P)H] activity
C4K15_RS16070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K15_RS16080	COG1120	ATPase activity
C4K15_RS16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K15_RS16090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K15_RS16095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K15_RS16100	COG4264	IucA IucC family
C4K15_RS16110	COG4264	IucA IucC family
C4K15_RS16115	COG2814	Major facilitator Superfamily
C4K15_RS16120	COG0019	diaminopimelate decarboxylase activity
C4K15_RS16125	COG4264	IucA IucC family
C4K15_RS16130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K15_RS16135	COG4774	siderophore transport
C4K15_RS16140	COG3712	iron ion homeostasis
C4K15_RS16145	COG1595	DNA-templated transcription, initiation
C4K15_RS16165	COG0174	glutamine synthetase
C4K15_RS16175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS16185	COG2200	EAL domain
C4K15_RS16210	COG2205	protein histidine kinase activity
C4K15_RS16210	COG0784	Response regulator, receiver
C4K15_RS16240	COG1522	sequence-specific DNA binding
C4K15_RS16250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K15_RS16260	COG0473	3-isopropylmalate dehydrogenase activity
C4K15_RS16295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K15_RS16300	COG0601	transmembrane transport
C4K15_RS16305	COG0747	negative chemotaxis
C4K15_RS16310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS16320	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS16350	COG0589	response to stress
C4K15_RS16355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS16360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS16365	COG1116	anion transmembrane transporter activity
C4K15_RS16380	COG4977	sequence-specific DNA binding
C4K15_RS16380	COG1917	Cupin 2, conserved barrel domain protein
C4K15_RS16385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS16395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS16400	COG1116	anion transmembrane transporter activity
C4K15_RS16420	COG0656	L-ascorbic acid biosynthetic process
C4K15_RS16425	COG2205	protein histidine kinase activity
C4K15_RS16425	COG0784	Response regulator, receiver
C4K15_RS16430	COG3300	MHYT domain
C4K15_RS16430	COG5001	Diguanylate cyclase
C4K15_RS16440	COG2197	response regulator
C4K15_RS16460	COG0513	Belongs to the DEAD box helicase family
C4K15_RS16480	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K15_RS16485	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K15_RS16530	COG1113	amino acid transport
C4K15_RS16550	COG0531	amino acid
C4K15_RS16575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K15_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS16600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS16615	COG0210	DNA helicase
C4K15_RS16630	COG3321	synthase
C4K15_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS16630	COG0604	alcohol dehydrogenase
C4K15_RS16645	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS16660	COG3469	chitinase activity
C4K15_RS16665	COG3397	chitin binding
C4K15_RS16670	COG0583	DNA-binding transcription factor activity
C4K15_RS16690	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS16710	COG2072	flavoprotein involved in K transport
C4K15_RS16715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS16720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS16725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS16740	COG1566	PFAM secretion protein HlyD family protein
C4K15_RS16765	COG2205	protein histidine kinase activity
C4K15_RS16765	COG0784	Response regulator, receiver
C4K15_RS16765	COG2198	Histidine kinase
C4K15_RS16775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K15_RS16780	COG0784	Response regulator, receiver
C4K15_RS16780	COG2205	protein histidine kinase activity
C4K15_RS16780	COG2198	Histidine kinase
C4K15_RS16800	COG0672	)-iron permease
C4K15_RS16805	COG2822	iron ion transport
C4K15_RS16820	COG2814	Major facilitator Superfamily
C4K15_RS16830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K15_RS16845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS16860	COG2816	NAD+ diphosphatase activity
C4K15_RS16865	COG1024	Enoyl-CoA hydratase
C4K15_RS16880	COG1335	isochorismatase
C4K15_RS16885	COG2205	protein histidine kinase activity
C4K15_RS16890	COG0745	RESPONSE REGULATOR receiver
C4K15_RS16895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS16940	COG1609	Transcriptional regulator
C4K15_RS16950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K15_RS17015	COG2814	Major facilitator Superfamily
C4K15_RS17020	COG1063	alcohol dehydrogenase
C4K15_RS17060	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS17065	COG3384	dioxygenase
C4K15_RS17075	COG2271	Major facilitator Superfamily
C4K15_RS17080	COG3971	2-oxopent-4-enoate hydratase activity
C4K15_RS17090	COG1929	Belongs to the glycerate kinase type-1 family
C4K15_RS17095	COG3835	regulator
C4K15_RS17100	COG2271	Major facilitator Superfamily
C4K15_RS17105	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS17115	COG0583	DNA-binding transcription factor activity
C4K15_RS17120	COG0667	Aldo Keto reductase
C4K15_RS17130	COG1846	Transcriptional regulator
C4K15_RS17140	COG0697	spore germination
C4K15_RS17145	COG0583	DNA-binding transcription factor activity
C4K15_RS17150	COG2200	EAL domain
C4K15_RS17215	COG3258	Cytochrome c
C4K15_RS17220	COG2863	cytochrome
C4K15_RS17240	COG3145	DNA-N1-methyladenine dioxygenase activity
C4K15_RS17245	COG2169	Transcriptional regulator
C4K15_RS17245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K15_RS17255	COG0604	alcohol dehydrogenase
C4K15_RS17275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4K15_RS17285	COG0488	(ABC) transporter
C4K15_RS17295	COG0393	Putative heavy-metal-binding
C4K15_RS17340	COG1733	regulation of RNA biosynthetic process
C4K15_RS17415	COG3179	chitinase
C4K15_RS17435	COG0583	DNA-binding transcription factor activity
C4K15_RS17440	COG0583	DNA-binding transcription factor activity
C4K15_RS17445	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K15_RS17450	COG0300	oxidoreductase activity
C4K15_RS17460	COG0583	DNA-binding transcription factor activity
C4K15_RS17465	COG1309	transcriptional regulator
C4K15_RS17490	COG0475	glutathione-regulated potassium exporter activity
C4K15_RS17495	COG1024	Enoyl-CoA hydratase
C4K15_RS17500	COG0515	serine threonine protein kinase
C4K15_RS17505	COG1073	alpha beta
C4K15_RS17520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS17525	COG0789	Transcriptional regulator
C4K15_RS17540	COG3604	Transcriptional regulator
C4K15_RS17545	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C4K15_RS17570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K15_RS17575	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K15_RS17605	COG3712	iron ion homeostasis
C4K15_RS17610	COG1595	DNA-templated transcription, initiation
C4K15_RS17650	COG0583	DNA-binding transcription factor activity
C4K15_RS17655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS17665	COG0861	Integral membrane protein TerC family
C4K15_RS17720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K15_RS17725	COG2207	Transcriptional regulator
C4K15_RS17730	COG1064	alcohol dehydrogenase
C4K15_RS17750	COG1733	regulation of RNA biosynthetic process
C4K15_RS17780	COG1022	Amp-dependent synthetase and ligase
C4K15_RS17785	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS17790	COG1024	Enoyl-CoA hydratase
C4K15_RS17805	COG2814	Major facilitator Superfamily
C4K15_RS17820	COG0577	efflux transmembrane transporter activity
C4K15_RS17820	COG1136	(ABC) transporter
C4K15_RS17825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS17890	COG2197	response regulator
C4K15_RS17920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K15_RS17930	COG1136	(ABC) transporter
C4K15_RS17935	COG2815	serine threonine protein kinase
C4K15_RS17935	COG0515	serine threonine protein kinase
C4K15_RS18070	COG4191	Histidine kinase
C4K15_RS18075	COG4566	intracellular signal transduction
C4K15_RS18080	COG4566	intracellular signal transduction
C4K15_RS18115	COG0583	DNA-binding transcription factor activity
C4K15_RS18120	COG1335	isochorismatase
C4K15_RS18125	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K15_RS18145	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4K15_RS18180	COG1741	Belongs to the pirin family
C4K15_RS18210	COG2814	Major facilitator Superfamily
C4K15_RS18225	COG1335	isochorismatase
C4K15_RS18245	COG2814	Major facilitator Superfamily
C4K15_RS18250	COG2010	Cytochrome c
C4K15_RS18250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K15_RS18255	COG2080	2 iron, 2 sulfur cluster binding
C4K15_RS18260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K15_RS18260	COG2010	Cytochrome c
C4K15_RS18265	COG1902	pentaerythritol trinitrate reductase activity
C4K15_RS18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS18270	COG2205	protein histidine kinase activity
C4K15_RS18275	COG1301	dicarboxylic acid transport
C4K15_RS18285	COG2207	Transcriptional regulator
C4K15_RS18290	COG0300	oxidoreductase activity
C4K15_RS18315	COG0322	excinuclease ABC activity
C4K15_RS18320	COG2197	response regulator
C4K15_RS18340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K15_RS18345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4K15_RS18350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K15_RS18355	COG4166	transmembrane transport
C4K15_RS18360	COG4174	ABC transporter (Permease)
C4K15_RS18365	COG4239	(ABC) transporter, permease
C4K15_RS18370	COG4172	Belongs to the ABC transporter superfamily
C4K15_RS18380	COG2610	gluconate transmembrane transporter activity
C4K15_RS18385	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS18390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K15_RS18400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K15_RS18405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K15_RS18445	COG1607	acyl-coa hydrolase
C4K15_RS18450	COG0069	glutamate synthase activity
C4K15_RS18455	COG2026	Addiction module toxin, RelE StbE family
C4K15_RS18485	COG2203	Gaf domain
C4K15_RS18485	COG2199	diguanylate cyclase activity
C4K15_RS18495	COG1253	flavin adenine dinucleotide binding
C4K15_RS18530	COG0583	DNA-binding transcription factor activity
C4K15_RS18590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4K15_RS18590	COG0316	Belongs to the HesB IscA family
C4K15_RS18625	COG0616	signal peptide processing
C4K15_RS18640	COG4172	Belongs to the ABC transporter superfamily
C4K15_RS18645	COG4239	(ABC) transporter, permease
C4K15_RS18650	COG4174	ABC transporter (Permease)
C4K15_RS18655	COG4166	transmembrane transport
C4K15_RS18665	COG4206	TonB-dependent receptor
C4K15_RS18675	COG1595	DNA-templated transcription, initiation
C4K15_RS18680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS18680	COG1024	Enoyl-CoA hydratase
C4K15_RS18700	COG3189	MarR family transcriptional regulator
C4K15_RS18705	COG2186	Transcriptional regulator
C4K15_RS18775	COG4191	Histidine kinase
C4K15_RS18775	COG0784	Response regulator, receiver
C4K15_RS18780	COG0587	DNA-directed DNA polymerase activity
C4K15_RS18795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K15_RS18815	COG2194	sulfuric ester hydrolase activity
C4K15_RS18820	COG0673	inositol 2-dehydrogenase activity
C4K15_RS18855	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS18865	COG0303	'Molybdopterin
C4K15_RS18870	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K15_RS18875	COG0746	molybdenum cofactor guanylyltransferase activity
C4K15_RS18880	COG0583	DNA-binding transcription factor activity
C4K15_RS18895	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K15_RS18900	COG3781	membrane
C4K15_RS18905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K15_RS18915	COG1271	oxidase subunit
C4K15_RS18920	COG1294	oxidase, subunit
C4K15_RS18935	COG0243	molybdopterin cofactor binding
C4K15_RS18940	COG0697	spore germination
C4K15_RS18945	COG1522	sequence-specific DNA binding
C4K15_RS19000	COG2989	Protein conserved in bacteria
C4K15_RS19015	COG3300	MHYT domain
C4K15_RS19015	COG5001	Diguanylate cyclase
C4K15_RS19025	COG1858	cytochrome C peroxidase
C4K15_RS19050	COG0579	oxidoreductase
C4K15_RS19100	COG2920	part of a sulfur-relay system
C4K15_RS19105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K15_RS19110	COG0435	Glutathione S-transferase
C4K15_RS19115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K15_RS19115	COG1648	precorrin-2 dehydrogenase activity
C4K15_RS19120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4K15_RS19125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4K15_RS19130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4K15_RS19135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4K15_RS19140	COG1674	ftsk spoiiie
C4K15_RS19145	COG0492	ferredoxin-NADP+ reductase activity
C4K15_RS19150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4K15_RS19155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4K15_RS19160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4K15_RS19165	COG0542	response to heat
C4K15_RS19170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4K15_RS19175	COG1278	Cold shock
C4K15_RS19200	COG0482	sulfurtransferase activity
C4K15_RS19205	COG2915	High frequency lysogenization protein hflD homolog
C4K15_RS19215	COG2850	peptidyl-arginine hydroxylation
C4K15_RS19220	COG2153	protein acetylation
C4K15_RS19235	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K15_RS19240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K15_RS19245	COG0649	NAD binding
C4K15_RS19245	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K15_RS19260	COG1034	ATP synthesis coupled electron transport
C4K15_RS19265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4K15_RS19270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K15_RS19280	COG0713	ATP synthesis coupled electron transport
C4K15_RS19295	COG1007	ATP synthesis coupled electron transport
C4K15_RS19300	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4K15_RS19305	COG2944	sequence-specific DNA binding
C4K15_RS19320	COG0395	ABC-type sugar transport system, permease component
C4K15_RS19330	COG3842	ATPase activity
C4K15_RS19335	COG3842	ATPase activity
C4K15_RS19340	COG3284	Transcriptional regulator
C4K15_RS19355	COG0215	cysteine-tRNA ligase activity
C4K15_RS19360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K15_RS19370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K15_RS19375	COG2814	Major facilitator Superfamily
C4K15_RS19380	COG1566	PFAM secretion protein HlyD family protein
C4K15_RS19390	COG1846	Transcriptional regulator
C4K15_RS19395	COG2911	Protein conserved in bacteria
C4K15_RS19400	COG0729	surface antigen
C4K15_RS19410	COG0708	Exodeoxyribonuclease III
C4K15_RS19420	COG2885	chlorophyll binding
C4K15_RS19435	COG0789	Transcriptional regulator
C4K15_RS19445	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS19450	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS19455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K15_RS19470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K15_RS19480	COG2866	Carboxypeptidase
C4K15_RS19490	COG2814	Major facilitator Superfamily
C4K15_RS19495	COG3038	cytochrome b561
C4K15_RS19550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K15_RS19560	COG0217	transcriptional regulatory protein
C4K15_RS19565	COG0583	DNA-binding transcription factor activity
C4K15_RS19570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4K15_RS19575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K15_RS19580	COG3038	cytochrome b561
C4K15_RS19590	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K15_RS19590	COG1902	pentaerythritol trinitrate reductase activity
C4K15_RS19615	COG2814	Major facilitator Superfamily
C4K15_RS19620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K15_RS19630	COG0776	regulation of translation
C4K15_RS19635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K15_RS19640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4K15_RS19645	COG0740	serine-type endopeptidase activity
C4K15_RS19650	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4K15_RS19670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4K15_RS19675	COG1686	Belongs to the peptidase S11 family
C4K15_RS19685	COG1253	flavin adenine dinucleotide binding
C4K15_RS19695	COG0583	DNA-binding transcription factor activity
C4K15_RS19705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4K15_RS19715	COG3132	Protein of unknown function, DUF480
C4K15_RS19725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K15_RS19745	COG0628	permease
C4K15_RS19750	COG0826	peptidase U32
C4K15_RS19760	COG2056	Na+-H+ antiporter family
C4K15_RS19765	COG0840	transmembrane signaling receptor activity
C4K15_RS19795	COG0720	synthase
C4K15_RS19805	COG0596	Alpha beta hydrolase
C4K15_RS19815	COG1051	belongs to the nudix hydrolase family
C4K15_RS19830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K15_RS19835	COG0402	S-adenosylhomocysteine deaminase activity
C4K15_RS19840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K15_RS19855	COG1725	Transcriptional regulator
C4K15_RS19860	COG0583	DNA-binding transcription factor activity
C4K15_RS19870	COG1522	sequence-specific DNA binding
C4K15_RS19880	COG2223	nitrite transmembrane transporter activity
C4K15_RS19885	COG4772	TonB-dependent receptor
C4K15_RS19895	COG1595	DNA-templated transcription, initiation
C4K15_RS19980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K15_RS19990	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS20000	COG4638	Rieske (2fe-2S)
C4K15_RS20015	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS20020	COG0154	amidase activity
C4K15_RS20035	COG0411	ABC transporter
C4K15_RS20050	COG0235	Class ii aldolase
C4K15_RS20095	COG2986	histidine ammonia-lyase
C4K15_RS20100	COG1304	FMN binding
C4K15_RS20105	COG0277	FAD linked oxidase domain protein
C4K15_RS20110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS20115	COG0765	amino acid transport
C4K15_RS20120	COG0765	amino acid transport
C4K15_RS20130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K15_RS20135	COG2188	Transcriptional regulator
C4K15_RS20190	COG0563	adenylate kinase activity
C4K15_RS20195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS20200	COG1126	abc transporter atp-binding protein
C4K15_RS20205	COG0765	amino acid transport
C4K15_RS20215	COG4221	oxidoreductase activity
C4K15_RS20220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K15_RS20230	COG1984	allophanate hydrolase subunit 2
C4K15_RS20235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K15_RS20245	COG0511	ligase activity, forming carbon-carbon bonds
C4K15_RS20255	COG0436	Aminotransferase
C4K15_RS20305	COG1196	nuclear chromosome segregation
C4K15_RS20345	COG2831	hemolysin activation secretion protein
C4K15_RS20390	COG2274	protein secretion by the type I secretion system
C4K15_RS20395	COG1538	Outer membrane efflux protein
C4K15_RS20400	COG2080	2 iron, 2 sulfur cluster binding
C4K15_RS20405	COG2010	Cytochrome c
C4K15_RS20405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K15_RS20410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K15_RS20410	COG2010	Cytochrome c
C4K15_RS20420	COG0840	transmembrane signaling receptor activity
C4K15_RS20425	COG4774	siderophore transport
C4K15_RS20430	COG0583	DNA-binding transcription factor activity
C4K15_RS20440	COG3591	Belongs to the peptidase S1B family
C4K15_RS20440	COG1864	DNA RNA non-specific endonuclease
C4K15_RS20460	COG4106	trans-aconitate 2-methyltransferase activity
C4K15_RS20480	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4K15_RS20490	COG3135	benzoate transporter
C4K15_RS20495	COG2814	Major facilitator Superfamily
C4K15_RS20525	COG3485	protocatechuate 3,4-dioxygenase
C4K15_RS20530	COG4829	muconolactone delta-isomerase
C4K15_RS20535	COG4948	Mandelate Racemase Muconate Lactonizing
C4K15_RS20570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K15_RS20615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4K15_RS20635	COG2814	Major facilitator Superfamily
C4K15_RS20665	COG0154	amidase activity
C4K15_RS20670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K15_RS20705	COG3318	Belongs to the UPF0149 family
C4K15_RS20705	COG3012	SEC-C Motif Domain Protein
C4K15_RS20710	COG0730	response to heat
C4K15_RS20735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K15_RS20745	COG1335	isochorismatase
C4K15_RS20750	COG1335	isochorismatase
C4K15_RS20760	COG0583	DNA-binding transcription factor activity
C4K15_RS20770	COG0656	L-ascorbic acid biosynthetic process
C4K15_RS20805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS20810	COG0577	efflux transmembrane transporter activity
C4K15_RS20810	COG1136	(ABC) transporter
C4K15_RS20815	COG1538	Outer membrane efflux protein
C4K15_RS20870	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4K15_RS20885	COG1309	transcriptional regulator
C4K15_RS20890	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS20895	COG3387	PFAM Glycoside hydrolase 15-related
C4K15_RS20910	COG0596	Alpha beta hydrolase
C4K15_RS20915	COG4977	sequence-specific DNA binding
C4K15_RS20925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K15_RS20930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4K15_RS21010	COG0840	transmembrane signaling receptor activity
C4K15_RS21045	COG1132	(ABC) transporter
C4K15_RS21085	COG0477	Major facilitator Superfamily
C4K15_RS21090	COG0583	DNA-binding transcription factor activity
C4K15_RS21095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K15_RS21100	COG0235	Class ii aldolase
C4K15_RS21105	COG0477	Major facilitator Superfamily
C4K15_RS21110	COG0583	DNA-binding transcription factor activity
C4K15_RS21115	COG0768	penicillin binding
C4K15_RS21125	COG1063	alcohol dehydrogenase
C4K15_RS21160	COG5006	permease, DMT superfamily
C4K15_RS21170	COG1309	transcriptional regulator
C4K15_RS21175	COG0300	oxidoreductase activity
C4K15_RS21200	COG0431	NADPH-dependent FMN reductase
C4K15_RS21205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS21215	COG3829	transcription factor binding
C4K15_RS21260	COG1121	(ABC) transporter
C4K15_RS21265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K15_RS21275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K15_RS21290	COG0642	Histidine kinase
C4K15_RS21300	COG4232	protein-disulfide reductase activity
C4K15_RS21305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4K15_RS21355	COG1309	transcriptional regulator
C4K15_RS21370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K15_RS21375	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS21395	COG3123	guanosine phosphorylase activity
C4K15_RS21400	COG0633	Ferredoxin
C4K15_RS21400	COG3217	Mosc domain protein beta barrel domain protein
C4K15_RS21415	COG3851	Histidine kinase
C4K15_RS21420	COG2197	response regulator
C4K15_RS21425	COG1597	lipid kinase activity
C4K15_RS21440	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K15_RS21445	COG0746	molybdenum cofactor guanylyltransferase activity
C4K15_RS21455	COG0564	pseudouridine synthase activity
C4K15_RS21480	COG0004	ammonium transporteR
C4K15_RS21500	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K15_RS21520	COG2197	response regulator
C4K15_RS21525	COG2205	protein histidine kinase activity
C4K15_RS21525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS21530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4K15_RS21535	COG1956	GAF domain-containing protein
C4K15_RS21545	COG5002	protein histidine kinase activity
C4K15_RS21545	COG0784	Response regulator, receiver
C4K15_RS21545	COG2205	protein histidine kinase activity
C4K15_RS21550	COG1846	Transcriptional regulator
C4K15_RS21555	COG0386	Belongs to the glutathione peroxidase family
C4K15_RS21560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K15_RS21565	COG0436	Aminotransferase
C4K15_RS21570	COG0501	Belongs to the peptidase M48B family
C4K15_RS21575	COG0500	methyltransferase
C4K15_RS21580	COG3384	dioxygenase
C4K15_RS21595	COG1024	Enoyl-CoA hydratase
C4K15_RS21605	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4K15_RS21610	COG3214	Protein conserved in bacteria
C4K15_RS21620	COG0583	DNA-binding transcription factor activity
C4K15_RS21630	COG0583	DNA-binding transcription factor activity
C4K15_RS21635	COG1846	Transcriptional regulator
C4K15_RS21640	COG1764	response to oxidative stress
C4K15_RS21650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4K15_RS21675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K15_RS21690	COG3617	BRO family, N-terminal domain
C4K15_RS21710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K15_RS21730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K15_RS21760	COG1376	ErfK ybiS ycfS ynhG family protein
C4K15_RS21775	COG4181	ATPase activity
C4K15_RS21780	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4K15_RS21785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K15_RS21800	COG2197	response regulator
C4K15_RS21810	COG2259	Doxx family
C4K15_RS21815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K15_RS21820	COG0084	hydrolase, TatD family'
C4K15_RS21855	COG0745	RESPONSE REGULATOR receiver
C4K15_RS21860	COG2205	protein histidine kinase activity
C4K15_RS21865	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4K15_RS21875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4K15_RS21935	COG0463	Glycosyl transferase, family 2
C4K15_RS21935	COG1216	Glycosyl transferase, family 2
C4K15_RS21975	COG1086	Polysaccharide biosynthesis protein
C4K15_RS21985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K15_RS22000	COG0776	regulation of translation
C4K15_RS22015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4K15_RS22020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4K15_RS22025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K15_RS22035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4K15_RS22045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4K15_RS22050	COG0402	S-adenosylhomocysteine deaminase activity
C4K15_RS22055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K15_RS22060	COG0546	phosphoglycolate phosphatase activity
C4K15_RS22065	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS22080	COG5002	protein histidine kinase activity
C4K15_RS22080	COG5001	Diguanylate cyclase
C4K15_RS22095	COG1054	Belongs to the UPF0176 family
C4K15_RS22100	COG0271	Belongs to the BolA IbaG family
C4K15_RS22110	COG0114	fumarate hydratase activity
C4K15_RS22115	COG0697	spore germination
C4K15_RS22120	COG0183	Belongs to the thiolase family
C4K15_RS22125	COG2326	polyphosphate kinase activity
C4K15_RS22130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4K15_RS22130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS22135	COG0367	asparagine synthase
C4K15_RS22140	COG0189	ligase activity
C4K15_RS22140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K15_RS22145	COG1363	Peptidase, m42
C4K15_RS22150	COG3089	Belongs to the UPF0270 family
C4K15_RS22155	COG1742	UPF0060 membrane protein
C4K15_RS22170	COG1368	sulfuric ester hydrolase activity
C4K15_RS22190	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS22200	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C4K15_RS22205	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4K15_RS22210	COG0235	Class ii aldolase
C4K15_RS22220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4K15_RS22225	COG1073	alpha beta
C4K15_RS22250	COG2840	Smr protein MutS2
C4K15_RS22255	COG0302	gtp cyclohydrolase
C4K15_RS22265	COG3385	transposase activity
C4K15_RS22270	COG0625	glutathione transferase activity
C4K15_RS22275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K15_RS22285	COG2252	PERMEase
C4K15_RS22315	COG4266	Belongs to the allantoicase family
C4K15_RS22320	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4K15_RS22330	COG2233	PERMEase
C4K15_RS22355	COG1560	Kdo2-lipid A biosynthetic process
C4K15_RS22360	COG0850	regulation of cytokinetic process
C4K15_RS22365	COG2894	cell division
C4K15_RS22370	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4K15_RS22375	COG0564	pseudouridine synthase activity
C4K15_RS22385	COG1362	aminopeptidase activity
C4K15_RS22390	COG0668	transmembrane transport
C4K15_RS22395	COG1473	amidohydrolase
C4K15_RS22425	COG3842	ATPase activity
C4K15_RS22435	COG0604	alcohol dehydrogenase
C4K15_RS22435	COG3321	synthase
C4K15_RS22435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K15_RS22435	COG4221	oxidoreductase activity
C4K15_RS22445	COG2200	EAL domain
C4K15_RS22470	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K15_RS22475	COG2010	Cytochrome c
C4K15_RS22505	COG2974	May be involved in recombination
C4K15_RS22510	COG0385	Bile acid
C4K15_RS22515	COG2076	Multidrug Resistance protein
C4K15_RS22545	COG2202	Pas domain
C4K15_RS22545	COG2205	protein histidine kinase activity
C4K15_RS22595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4K15_RS22600	COG0406	alpha-ribazole phosphatase activity
C4K15_RS22605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4K15_RS22615	COG1492	cobalamin metabolic process
C4K15_RS22630	COG0778	Nitroreductase
C4K15_RS22635	COG1797	cobyrinic acid a,c-diamide synthase activity
C4K15_RS22660	COG0791	NLP P60 protein
C4K15_RS22665	COG0791	NLP P60 protein
C4K15_RS22670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K15_RS22675	COG0628	permease
C4K15_RS22685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4K15_RS22690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4K15_RS22705	COG3122	Protein conserved in bacteria
C4K15_RS22710	COG3956	TIGRFAM MazG family protein
C4K15_RS22715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K15_RS22720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K15_RS22740	COG0784	Response regulator, receiver
C4K15_RS22740	COG2205	protein histidine kinase activity
C4K15_RS22740	COG5002	protein histidine kinase activity
C4K15_RS22745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K15_RS22765	COG1393	Belongs to the ArsC family
C4K15_RS22785	COG0037	tRNA processing
C4K15_RS22795	COG3091	SprT-like family
C4K15_RS22800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K15_RS22840	COG2205	protein histidine kinase activity
C4K15_RS22845	COG0745	RESPONSE REGULATOR receiver
C4K15_RS22850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K15_RS22850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K15_RS22865	COG1558	bacterial-type flagellum-dependent cell motility
C4K15_RS22870	COG1815	bacterial-type flagellum-dependent cell motility
C4K15_RS22875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K15_RS22880	COG0784	Response regulator, receiver
C4K15_RS22880	COG0835	chemotaxis
C4K15_RS22900	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4K15_RS22905	COG0477	Major facilitator Superfamily
C4K15_RS22915	COG2205	protein histidine kinase activity
C4K15_RS22945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS22975	COG2239	Acts as a magnesium transporter
C4K15_RS22995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K15_RS23000	COG0527	aspartate kinase activity
C4K15_RS23005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K15_RS23010	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4K15_RS23015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K15_RS23020	COG2988	succinylglutamate desuccinylase activity
C4K15_RS23030	COG3724	N-succinylarginine dihydrolase activity
C4K15_RS23035	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS23050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K15_RS23080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS23085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K15_RS23095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K15_RS23130	COG0563	adenylate kinase activity
C4K15_RS23145	COG3706	GGDEF domain
C4K15_RS23165	COG0504	CTP synthase activity
C4K15_RS23170	COG2329	Antibiotic biosynthesis monooxygenase
C4K15_RS23180	COG0584	glycerophosphoryl diester phosphodiesterase
C4K15_RS23210	COG0306	phosphate transporter
C4K15_RS23220	COG3008	intermembrane lipid transfer
C4K15_RS23225	COG2995	paraquat-inducible protein a
C4K15_RS23230	COG2995	paraquat-inducible protein a
C4K15_RS23250	COG4941	Belongs to the sigma-70 factor family
C4K15_RS23260	COG3795	YCII-related domain
C4K15_RS23305	COG0436	Aminotransferase
C4K15_RS23315	COG3265	gluconokinase activity
C4K15_RS23320	COG1609	Transcriptional regulator
C4K15_RS23325	COG0583	DNA-binding transcription factor activity
C4K15_RS23335	COG0625	glutathione transferase activity
C4K15_RS23340	COG2271	Major facilitator Superfamily
C4K15_RS23350	COG0583	DNA-binding transcription factor activity
C4K15_RS23360	COG2986	histidine ammonia-lyase
C4K15_RS23370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS23385	COG3712	iron ion homeostasis
C4K15_RS23390	COG1595	DNA-templated transcription, initiation
C4K15_RS23415	COG0242	peptide deformylase activity
C4K15_RS23420	COG1295	ribonuclease BN
C4K15_RS23435	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS23440	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS23445	COG2267	carboxylic ester hydrolase activity
C4K15_RS23450	COG2030	dehydratase
C4K15_RS23480	COG3530	Putative quorum-sensing-regulated virulence factor
C4K15_RS23485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K15_RS23490	COG0800	Aldolase
C4K15_RS23505	COG1737	Transcriptional regulator
C4K15_RS23510	COG0676	glucose-6-phosphate 1-epimerase activity
C4K15_RS23520	COG3842	ATPase activity
C4K15_RS23525	COG0395	ABC-type sugar transport system, permease component
C4K15_RS23530	COG1175	transmembrane transport
C4K15_RS23535	COG1653	transport
C4K15_RS23570	COG1803	Methylglyoxal synthase
C4K15_RS23580	COG3712	iron ion homeostasis
C4K15_RS23585	COG4771	TonB-dependent receptor
C4K15_RS23595	COG2832	Protein of unknown function (DUF454)
C4K15_RS23600	COG0840	transmembrane signaling receptor activity
C4K15_RS23605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K15_RS23625	COG2235	arginine
C4K15_RS23630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K15_RS23655	COG0509	glycine decarboxylation via glycine cleavage system
C4K15_RS23660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K15_RS23660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K15_RS23665	COG1760	l-serine dehydratase
C4K15_RS23675	COG1278	Cold shock
C4K15_RS23685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4K15_RS23690	COG4964	Belongs to the GSP D family
C4K15_RS23780	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K15_RS23785	COG1129	ABC transporter
C4K15_RS23790	COG1879	ABC-type sugar transport system periplasmic component
C4K15_RS23800	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS23830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K15_RS23835	COG0602	queuosine metabolic process
C4K15_RS23840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4K15_RS23845	COG2885	chlorophyll binding
C4K15_RS23850	COG0823	Involved in the tonB-independent uptake of proteins
C4K15_RS23870	COG0824	Thioesterase
C4K15_RS23875	COG2255	four-way junction helicase activity
C4K15_RS23880	COG0632	four-way junction helicase activity
C4K15_RS23885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4K15_RS23890	COG0217	transcriptional regulatory protein
C4K15_RS23895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4K15_RS23905	COG0783	Belongs to the Dps family
C4K15_RS23915	COG2900	Belongs to the SlyX family
C4K15_RS23935	COG0668	transmembrane transport
C4K15_RS23940	COG1666	GTP binding
C4K15_RS23950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS23950	COG4191	Histidine kinase
C4K15_RS23955	COG2096	Adenosyltransferase
C4K15_RS23960	COG0352	thiamine-phosphate diphosphorylase activity
C4K15_RS23970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4K15_RS23975	COG0653	protein targeting
C4K15_RS23985	COG0433	COG0433 Predicted ATPase
C4K15_RS23995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K15_RS23995	COG0438	transferase activity, transferring glycosyl groups
C4K15_RS24025	COG2925	Exonuclease
C4K15_RS24050	COG0714	Associated with various cellular activities
C4K15_RS24070	COG0469	pyruvate kinase activity
C4K15_RS24075	COG1024	Enoyl-CoA hydratase
C4K15_RS24085	COG3706	GGDEF domain
C4K15_RS24100	COG4191	Histidine kinase
C4K15_RS24110	COG0477	Major facilitator Superfamily
C4K15_RS24140	COG2207	Transcriptional regulator
C4K15_RS24145	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS24155	COG0583	DNA-binding transcription factor activity
C4K15_RS24160	COG2910	NAD(P)H-binding
C4K15_RS24170	COG0583	DNA-binding transcription factor activity
C4K15_RS24200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K15_RS24205	COG0583	DNA-binding transcription factor activity
C4K15_RS24220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4K15_RS24250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS24255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K15_RS24265	COG3642	lipopolysaccharide core region biosynthetic process
C4K15_RS24275	COG0642	Histidine kinase
C4K15_RS24290	COG0459	protein refolding
C4K15_RS24295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4K15_RS24305	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4K15_RS24315	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS24320	COG0489	protein tyrosine kinase activity
C4K15_RS24325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K15_RS24325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K15_RS24330	COG4657	Part of a membrane complex involved in electron transport
C4K15_RS24335	COG2878	Part of a membrane complex involved in electron transport
C4K15_RS24340	COG4658	electron transport chain
C4K15_RS24350	COG4660	Part of a membrane complex involved in electron transport
C4K15_RS24355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4K15_RS24365	COG2197	response regulator
C4K15_RS24370	COG0137	argininosuccinate synthase activity
C4K15_RS24380	COG0418	dihydroorotase activity
C4K15_RS24385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K15_RS24390	COG0450	alkyl hydroperoxide reductase
C4K15_RS24405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4K15_RS24410	COG0243	molybdopterin cofactor binding
C4K15_RS24420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K15_RS24425	COG3842	ATPase activity
C4K15_RS24435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4K15_RS24445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4K15_RS24465	COG0765	amino acid transport
C4K15_RS24470	COG0765	amino acid transport
C4K15_RS24475	COG1126	abc transporter atp-binding protein
C4K15_RS24505	COG2076	Multidrug Resistance protein
C4K15_RS24525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K15_RS24540	COG4191	Histidine kinase
C4K15_RS24545	COG2204	response regulator
C4K15_RS24550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K15_RS24555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4K15_RS24560	COG0583	DNA-binding transcription factor activity
C4K15_RS24565	COG0456	acetyltransferase
C4K15_RS24570	COG1280	lysine exporter protein (LysE YggA)
C4K15_RS24580	COG0254	rRNA binding
C4K15_RS24585	COG2197	response regulator
C4K15_RS24590	COG0069	glutamate synthase activity
C4K15_RS24615	COG2246	polysaccharide biosynthetic process
C4K15_RS24630	COG1113	amino acid transport
C4K15_RS24640	COG1695	Transcriptional regulator
C4K15_RS24645	COG2375	cellular response to nickel ion
C4K15_RS24655	COG4628	conserved protein (DUF2132)
C4K15_RS24660	COG4206	TonB-dependent receptor
C4K15_RS24695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K15_RS24710	COG2226	methyltransferase
C4K15_RS24715	COG0500	methyltransferase
C4K15_RS24720	COG0590	tRNA wobble adenosine to inosine editing
C4K15_RS24735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K15_RS24735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K15_RS24745	COG0366	Alpha amylase catalytic
C4K15_RS24750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K15_RS24750	COG1263	PTS System
C4K15_RS24755	COG2188	Transcriptional regulator
C4K15_RS24780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K15_RS24780	COG0519	Catalyzes the synthesis of GMP from XMP
C4K15_RS24805	COG1570	exodeoxyribonuclease VII activity
C4K15_RS24810	COG0739	heme binding
C4K15_RS24815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K15_RS24830	COG0436	Aminotransferase
C4K15_RS24835	COG1160	GTP binding
C4K15_RS24850	COG0124	histidyl-tRNA synthetase
C4K15_RS24855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4K15_RS24860	COG1426	Protein conserved in bacteria
C4K15_RS24870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4K15_RS24875	COG0105	UTP biosynthetic process
C4K15_RS24885	COG0633	Ferredoxin
C4K15_RS24890	COG0443	Heat shock 70 kDa protein
C4K15_RS24895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K15_RS24910	COG1104	cysteine desulfurase activity
C4K15_RS24920	COG1045	serine acetyltransferase
C4K15_RS24935	COG3134	Outer membrane lipoprotein
C4K15_RS24950	COG1862	Preprotein translocase
C4K15_RS24955	COG0343	queuine tRNA-ribosyltransferase activity
C4K15_RS24960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4K15_RS24990	COG2853	Lipoprotein
C4K15_RS25020	COG0586	Pfam SNARE associated Golgi protein
C4K15_RS25065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K15_RS25080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K15_RS25080	COG5322	oxidoreductase activity
C4K15_RS25095	COG2771	luxR family
C4K15_RS25100	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS25120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K15_RS25135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K15_RS25140	COG0109	protoheme IX farnesyltransferase activity
C4K15_RS25150	COG1845	cytochrome c oxidase, subunit III
C4K15_RS25155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K15_RS25160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K15_RS25170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K15_RS25180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K15_RS25180	COG1017	nitric oxide dioxygenase activity
C4K15_RS25190	COG0835	chemotaxis
C4K15_RS25190	COG0784	Response regulator, receiver
C4K15_RS25220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K15_RS25230	COG5002	protein histidine kinase activity
C4K15_RS25245	COG3706	GGDEF domain
C4K15_RS25245	COG2203	Gaf domain
C4K15_RS25245	COG5001	Diguanylate cyclase
C4K15_RS25245	COG4251	negative regulation of phosphorylation
C4K15_RS25250	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4K15_RS25255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4K15_RS25270	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K15_RS25275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K15_RS25280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K15_RS25285	COG0772	Belongs to the SEDS family
C4K15_RS25290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4K15_RS25295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K15_RS25300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4K15_RS25305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K15_RS25320	COG0275	rRNA processing
C4K15_RS25325	COG2001	Belongs to the MraZ family
C4K15_RS25340	COG3107	peptidoglycan biosynthetic process
C4K15_RS25345	COG0792	nuclease activity
C4K15_RS25350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4K15_RS25355	COG2823	Periplasmic or secreted lipoprotein
C4K15_RS25360	COG2969	positive regulation of protein catabolic process
C4K15_RS25365	COG0625	glutathione transferase activity
C4K15_RS25370	COG2857	Cytochrome c1
C4K15_RS25375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4K15_RS25380	COG0723	plastoquinol--plastocyanin reductase activity
C4K15_RS25385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4K15_RS25390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4K15_RS25395	COG0667	Aldo Keto reductase
C4K15_RS25400	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS25410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K15_RS25415	COG0180	Tryptophanyl-tRNA synthetase
C4K15_RS25435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K15_RS25450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4K15_RS25460	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS25490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K15_RS25500	COG2771	luxR family
C4K15_RS25505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K15_RS25520	COG0745	RESPONSE REGULATOR receiver
C4K15_RS25525	COG0642	Histidine kinase
C4K15_RS25530	COG2909	trisaccharide binding
C4K15_RS25545	COG0318	PFAM AMP-dependent synthetase and ligase
C4K15_RS25565	COG1280	lysine exporter protein (LysE YggA)
C4K15_RS25570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K15_RS25575	COG2813	Specifically methylates the guanine in position
C4K15_RS25580	COG2119	membrane
C4K15_RS25585	COG0501	Belongs to the peptidase M48B family
C4K15_RS25590	COG0840	transmembrane signaling receptor activity
C4K15_RS25595	COG2135	peptidase activity
C4K15_RS25655	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4K15_RS25660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4K15_RS25670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4K15_RS25675	COG1090	epimerase
C4K15_RS25680	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4K15_RS25690	COG0789	Transcriptional regulator
C4K15_RS25695	COG0415	Belongs to the DNA photolyase family
C4K15_RS25710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4K15_RS25715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4K15_RS25725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4K15_RS25730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4K15_RS25740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4K15_RS25745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4K15_RS25755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4K15_RS25760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4K15_RS25765	COG0193	aminoacyl-tRNA hydrolase activity
C4K15_RS25780	COG0583	DNA-binding transcription factor activity
C4K15_RS25785	COG2197	response regulator
C4K15_RS25790	COG2205	protein histidine kinase activity
C4K15_RS25790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS25795	COG3397	chitin binding
C4K15_RS25860	COG2258	MOSC domain
C4K15_RS25865	COG2223	nitrite transmembrane transporter activity
C4K15_RS25870	COG0583	DNA-binding transcription factor activity
C4K15_RS25875	COG3842	ATPase activity
C4K15_RS25880	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K15_RS25885	COG1177	transmembrane transport
C4K15_RS25955	COG0405	Gamma-glutamyltransferase
C4K15_RS25970	COG4680	protein conserved in bacteria
C4K15_RS25985	COG0789	Transcriptional regulator
C4K15_RS26000	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K15_RS26015	COG3655	Transcriptional regulator
C4K15_RS26035	COG0662	Cupin 2, conserved barrel domain protein
C4K15_RS26045	COG0583	DNA-binding transcription factor activity
C4K15_RS26050	COG0583	DNA-binding transcription factor activity
C4K15_RS26060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K15_RS26065	COG1028	Short-chain dehydrogenase reductase Sdr
C4K15_RS26070	COG0583	DNA-binding transcription factor activity
C4K15_RS26145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K15_RS26160	COG2031	fatty acid transporter
C4K15_RS26175	COG0288	reversible hydration of carbon dioxide
C4K15_RS26185	COG0456	acetyltransferase
C4K15_RS26210	COG3008	intermembrane lipid transfer
C4K15_RS26215	COG2995	paraquat-inducible protein a
C4K15_RS26220	COG2995	paraquat-inducible protein a
C4K15_RS26255	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4K15_RS26260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4K15_RS26265	COG1183	phosphatidylcholine synthase activity
C4K15_RS26270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4K15_RS26280	COG0028	Belongs to the TPP enzyme family
C4K15_RS26300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K15_RS26330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4K15_RS26335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K15_RS26340	COG4558	Periplasmic binding protein
C4K15_RS26350	COG1489	DNA binding
C4K15_RS26355	COG0436	Aminotransferase
C4K15_RS26365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K15_RS26375	COG4191	Histidine kinase
C4K15_RS26400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K15_RS26405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4K15_RS26415	COG0166	Belongs to the GPI family
C4K15_RS26420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K15_RS26435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K15_RS26445	COG2823	Periplasmic or secreted lipoprotein
C4K15_RS26460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4K15_RS26465	COG0237	dephospho-CoA kinase activity
C4K15_RS26470	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4K15_RS26490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K15_RS26545	COG0728	peptidoglycan biosynthetic process
C4K15_RS26560	COG1252	NADH dehydrogenase
C4K15_RS26570	COG3121	Chaperone
C4K15_RS26575	COG3188	usher protein
C4K15_RS26605	COG0542	response to heat
C4K15_RS26635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS26675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4K15_RS26680	COG1047	Peptidyl-prolyl cis-trans
C4K15_RS26685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4K15_RS26690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4K15_RS26695	COG0196	riboflavin kinase activity
C4K15_RS26710	COG0268	Binds directly to 16S ribosomal RNA
C4K15_RS26715	COG3045	CreA protein
C4K15_RS26720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4K15_RS26725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4K15_RS26730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4K15_RS26735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4K15_RS26740	COG0142	geranyltranstransferase activity
C4K15_RS26745	COG2824	Alkylphosphonate utilization operon protein PhnA
C4K15_RS26750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K15_RS26755	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K15_RS26765	COG2862	Uncharacterized protein family, UPF0114
C4K15_RS26780	COG1067	ATP-dependent peptidase activity
C4K15_RS26800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K15_RS26810	COG0488	(ABC) transporter
C4K15_RS26820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K15_RS26835	COG2186	Transcriptional regulator
C4K15_RS26845	COG0523	cobalamin synthesis protein
C4K15_RS26850	COG2879	small protein
C4K15_RS26855	COG1966	Carbon starvation protein
C4K15_RS26860	COG2020	methyltransferase activity
C4K15_RS26890	COG1970	mechanosensitive ion channel activity
C4K15_RS26900	COG2813	Specifically methylates the guanine in position
C4K15_RS26910	COG1294	oxidase, subunit
C4K15_RS26915	COG1271	oxidase subunit
C4K15_RS26940	COG2252	PERMEase
C4K15_RS26945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K15_RS26950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K15_RS26955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K15_RS26960	COG3135	benzoate transporter
C4K15_RS26970	COG1309	transcriptional regulator
C4K15_RS26975	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4K15_RS26975	COG1082	Xylose isomerase domain protein TIM barrel
C4K15_RS26995	COG0673	inositol 2-dehydrogenase activity
C4K15_RS27005	COG1053	succinate dehydrogenase
C4K15_RS27010	COG3485	protocatechuate 3,4-dioxygenase
C4K15_RS27015	COG3485	protocatechuate 3,4-dioxygenase
C4K15_RS27020	COG0583	DNA-binding transcription factor activity
C4K15_RS27025	COG2321	neutral zinc metallopeptidase
C4K15_RS27040	COG1946	Acyl-CoA thioesterase
C4K15_RS27050	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4K15_RS27060	COG0513	Belongs to the DEAD box helicase family
C4K15_RS27070	COG0697	spore germination
C4K15_RS27075	COG1522	sequence-specific DNA binding
C4K15_RS27080	COG1199	ATP-dependent helicase activity
C4K15_RS27080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K15_RS27090	COG3416	Protein conserved in bacteria
C4K15_RS27105	COG1643	Atp-dependent helicase
C4K15_RS27125	COG1522	sequence-specific DNA binding
C4K15_RS27140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K15_RS27145	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS27155	COG0351	phosphomethylpyrimidine kinase
C4K15_RS27160	COG0352	thiamine-phosphate diphosphorylase activity
C4K15_RS27165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K15_RS27180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K15_RS27185	COG1702	phosphate starvation-inducible protein PhoH
C4K15_RS27190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4K15_RS27195	COG4535	Mg2 and Co2 transporter CorC
C4K15_RS27205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4K15_RS27220	COG0495	leucyl-tRNA aminoacylation
C4K15_RS27240	COG2951	lytic endotransglycosylase activity
C4K15_RS27245	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4K15_RS27250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4K15_RS27255	COG0321	lipoyl(octanoyl) transferase activity
C4K15_RS27260	COG2921	Belongs to the UPF0250 family
C4K15_RS27265	COG1686	Belongs to the peptidase S11 family
C4K15_RS27275	COG2951	lytic endotransglycosylase activity
C4K15_RS27280	COG0772	Belongs to the SEDS family
C4K15_RS27285	COG0768	penicillin binding
C4K15_RS27290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4K15_RS27300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4K15_RS27305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4K15_RS27310	COG2094	Belongs to the DNA glycosylase MPG family
C4K15_RS27315	COG0586	Pfam SNARE associated Golgi protein
C4K15_RS27325	COG1346	cytolysis
C4K15_RS27345	COG0702	epimerase
C4K15_RS27360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K15_RS27365	COG3284	Transcriptional regulator
C4K15_RS27380	COG4303	Ethanolamine ammonia lyase large subunit
C4K15_RS27385	COG4302	ethanolamine ammonia-lyase activity
C4K15_RS27390	COG0456	acetyltransferase
C4K15_RS27395	COG0586	Pfam SNARE associated Golgi protein
C4K15_RS27400	COG3228	Belongs to the MtfA family
C4K15_RS27405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4K15_RS27420	COG2070	2-Nitropropane dioxygenase
C4K15_RS27430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K15_RS27435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS27440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K15_RS27445	COG0473	3-isopropylmalate dehydrogenase activity
C4K15_RS27445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K15_RS27450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K15_RS27460	COG2814	Major facilitator Superfamily
C4K15_RS27475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS27490	COG0583	DNA-binding transcription factor activity
C4K15_RS27495	COG2207	Transcriptional regulator
C4K15_RS27505	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K15_RS27510	COG3657	addiction module killer protein
C4K15_RS27520	COG0604	alcohol dehydrogenase
C4K15_RS27520	COG3321	synthase
C4K15_RS27525	COG0640	Transcriptional regulator
C4K15_RS27535	COG1722	exodeoxyribonuclease VII activity
C4K15_RS27540	COG0142	geranyltranstransferase activity
C4K15_RS27545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4K15_RS27550	COG4206	TonB-dependent receptor
C4K15_RS27565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4K15_RS27575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4K15_RS27585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4K15_RS27590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K15_RS27605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K15_RS27605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K15_RS27610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K15_RS27620	COG2264	protein methyltransferase activity
C4K15_RS27625	COG3118	belongs to the thioredoxin family
C4K15_RS27655	COG3047	cAMP biosynthetic process
C4K15_RS27660	COG3385	transposase activity
C4K15_RS27675	COG1201	RNA secondary structure unwinding
C4K15_RS27680	COG2814	Major facilitator Superfamily
C4K15_RS27690	COG3568	Endonuclease Exonuclease Phosphatase
C4K15_RS27695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K15_RS27700	COG0392	lysyltransferase activity
C4K15_RS27720	COG1335	isochorismatase
C4K15_RS27725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K15_RS27770	COG0629	single-stranded DNA binding
C4K15_RS27775	COG2814	Major facilitator Superfamily
C4K15_RS27780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4K15_RS27785	COG2193	ferroxidase activity
C4K15_RS27795	COG0203	ribosomal protein L17
C4K15_RS27800	COG0202	RNA polymerase activity
C4K15_RS27805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4K15_RS27810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4K15_RS27815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4K15_RS27820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4K15_RS27830	COG0200	Binds to the 23S rRNA
C4K15_RS27835	COG1841	ribosomal large subunit assembly
C4K15_RS27840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4K15_RS27845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4K15_RS27850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4K15_RS27855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4K15_RS27860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4K15_RS27865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4K15_RS27870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4K15_RS27875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4K15_RS27880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4K15_RS27885	COG0255	Belongs to the universal ribosomal protein uL29 family
C4K15_RS27890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4K15_RS27895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4K15_RS27900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4K15_RS27905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4K15_RS27910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4K15_RS27915	COG0089	rRNA binding
C4K15_RS27920	COG0088	Forms part of the polypeptide exit tunnel
C4K15_RS27925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4K15_RS27930	COG0051	transcription antitermination factor activity, RNA binding
C4K15_RS27935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K15_RS27940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K15_RS27945	COG0049	tRNA binding
C4K15_RS27950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4K15_RS27955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4K15_RS27960	COG0085	RNA polymerase activity
C4K15_RS27965	COG0222	ribosome binding
C4K15_RS27970	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4K15_RS27975	COG0081	regulation of translation
C4K15_RS27980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4K15_RS28000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K15_RS28025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4K15_RS28065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4K15_RS28070	COG0739	heme binding
C4K15_RS28075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4K15_RS28080	COG0316	Belongs to the HesB IscA family
C4K15_RS28085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K15_RS28090	COG1981	membrane
C4K15_RS28105	COG4221	oxidoreductase activity
C4K15_RS28110	COG0537	adenosine 5'-monophosphoramidase activity
C4K15_RS28115	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4K15_RS28120	COG1765	OsmC-like protein
C4K15_RS28135	COG0134	indole-3-glycerol-phosphate synthase activity
C4K15_RS28140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K15_RS28145	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K15_RS28155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K15_RS28160	COG0546	phosphoglycolate phosphatase activity
C4K15_RS28165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4K15_RS28170	COG1454	alcohol dehydrogenase
C4K15_RS28180	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K15_RS28190	COG3842	ATPase activity
C4K15_RS28195	COG2197	response regulator
C4K15_RS28200	COG4585	Histidine kinase
C4K15_RS28210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K15_RS28215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K15_RS28220	COG3178	'Phosphotransferase
C4K15_RS28225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4K15_RS28230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K15_RS28235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4K15_RS28240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4K15_RS28245	COG2967	ApaG domain
C4K15_RS28250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K15_RS28255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K15_RS28260	COG2766	serine protein kinase
C4K15_RS28265	COG2718	Belongs to the UPF0229 family
C4K15_RS28270	COG2719	SpoVR family
C4K15_RS28275	COG0617	tRNA 3'-terminal CCA addition
C4K15_RS28285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K15_RS28290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4K15_RS28295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4K15_RS28300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4K15_RS28305	COG0358	DNA primase activity
C4K15_RS28310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4K15_RS28345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K15_RS28350	COG1025	Belongs to the peptidase M16 family
C4K15_RS28360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K15_RS28365	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4K15_RS28375	COG0535	radical SAM domain protein
C4K15_RS28400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K15_RS28405	COG2258	MOSC domain
C4K15_RS28410	COG0583	DNA-binding transcription factor activity
C4K15_RS28415	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS28420	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS28425	COG3706	GGDEF domain
C4K15_RS28430	COG1960	acyl-CoA dehydrogenase activity
C4K15_RS28450	COG2226	methyltransferase
C4K15_RS28450	COG1073	alpha beta
C4K15_RS28455	COG0156	8-amino-7-oxononanoate synthase activity
C4K15_RS28460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4K15_RS28470	COG3585	molybdate ion transport
C4K15_RS28470	COG2005	Transcriptional regulator
C4K15_RS28480	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4K15_RS28495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4K15_RS28515	COG1595	DNA-templated transcription, initiation
C4K15_RS28520	COG3712	iron ion homeostasis
C4K15_RS28525	COG4774	siderophore transport
C4K15_RS28545	COG0625	glutathione transferase activity
C4K15_RS28550	COG4452	Inner membrane protein CreD
C4K15_RS28555	COG2205	protein histidine kinase activity
C4K15_RS28560	COG0745	RESPONSE REGULATOR receiver
C4K15_RS28565	COG0189	ligase activity
C4K15_RS28565	COG4067	protein conserved in archaea
C4K15_RS28570	COG0204	Acyl-transferase
C4K15_RS28585	COG1063	alcohol dehydrogenase
C4K15_RS28615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K15_RS28630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K15_RS28645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K15_RS28645	COG1017	nitric oxide dioxygenase activity
C4K15_RS28655	COG4638	Rieske (2fe-2S)
C4K15_RS28665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4K15_RS28670	COG0247	lactate metabolic process
C4K15_RS28670	COG2181	nitrate reductase activity
C4K15_RS28675	COG1902	pentaerythritol trinitrate reductase activity
C4K15_RS28675	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K15_RS28725	COG3246	L-lysine catabolic process to acetate
C4K15_RS28730	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K15_RS28760	COG1760	l-serine dehydratase
C4K15_RS28770	COG4176	ABC-type proline glycine betaine transport system permease component
C4K15_RS28775	COG4175	Glycine betaine
C4K15_RS28780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K15_RS28785	COG1309	transcriptional regulator
C4K15_RS28790	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS28795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K15_RS28810	COG0312	modulator of DNA gyrase
C4K15_RS28815	COG0477	Major facilitator Superfamily
C4K15_RS28820	COG0513	Belongs to the DEAD box helicase family
C4K15_RS28825	COG2081	HI0933 family
C4K15_RS28830	COG1289	transmembrane transporter activity
C4K15_RS28840	COG2153	protein acetylation
C4K15_RS28850	COG1451	nucleotide metabolic process
C4K15_RS28880	COG0126	phosphoglycerate kinase activity
C4K15_RS28885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4K15_RS28895	COG4106	trans-aconitate 2-methyltransferase activity
C4K15_RS28900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4K15_RS28910	COG1422	Protein of unknown function (DUF1090)
C4K15_RS28935	COG2814	Major facilitator Superfamily
C4K15_RS28945	COG2116	formate transmembrane transporter activity
C4K15_RS28955	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4K15_RS28960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4K15_RS28975	COG0513	Belongs to the DEAD box helicase family
C4K15_RS28980	COG2353	YceI-like domain
C4K15_RS28985	COG3038	cytochrome b561
C4K15_RS28995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4K15_RS29000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS29020	COG1272	protein, Hemolysin III
C4K15_RS29040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K15_RS29060	COG3052	prosthetic group binding
C4K15_RS29065	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4K15_RS29090	COG0643	Histidine kinase
C4K15_RS29090	COG0784	Response regulator, receiver
C4K15_RS29090	COG2198	Histidine kinase
C4K15_RS29115	COG0189	ligase activity
C4K15_RS29125	COG1678	Uncharacterized ACR, COG1678
C4K15_RS29130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4K15_RS29135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4K15_RS29140	COG0540	Belongs to the ATCase OTCase family
C4K15_RS29145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K15_RS29155	COG0791	NLP P60 protein
C4K15_RS29180	COG1872	DUF167
C4K15_RS29185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K15_RS29190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K15_RS29190	COG2813	Specifically methylates the guanine in position
C4K15_RS29200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4K15_RS29205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4K15_RS29215	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C4K15_RS29220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4K15_RS29225	COG2022	thiamine diphosphate biosynthetic process
C4K15_RS29235	COG2363	Small membrane protein
C4K15_RS29240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K15_RS29250	COG2177	Part of the ABC transporter FtsEX involved in
C4K15_RS29255	COG2884	Cell division ATP-binding protein ftsE
C4K15_RS29260	COG0552	protein localization to endoplasmic reticulum
C4K15_RS29270	COG0612	Peptidase, M16
C4K15_RS29275	COG0612	Peptidase, M16
C4K15_RS29280	COG0742	ribosomal rna small subunit methyltransferase
C4K15_RS29315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K15_RS29320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4K15_RS29325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4K15_RS29330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4K15_RS29340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K15_RS29350	COG0129	dihydroxy-acid dehydratase activity
C4K15_RS29375	COG1823	symporter activity
C4K15_RS29390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K15_RS29405	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K15_RS29410	COG1178	ABC-type Fe3 transport system permease component
C4K15_RS29415	COG3842	ATPase activity
C4K15_RS29420	COG0583	DNA-binding transcription factor activity
C4K15_RS29430	COG0789	Transcriptional regulator
C4K15_RS29435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4K15_RS29440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4K15_RS29445	COG0730	response to heat
C4K15_RS29455	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C4K15_RS29460	COG0494	nUDIX hydrolase
C4K15_RS29475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K15_RS29480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4K15_RS29485	COG2234	aminopeptidase activity
C4K15_RS29490	COG3204	pilus organization
C4K15_RS29495	COG3204	pilus organization
C4K15_RS29500	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K15_RS29505	COG0277	FAD linked oxidase domain protein
C4K15_RS29510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K15_RS29520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS29525	COG1683	Conserved Protein
C4K15_RS29560	COG1177	transmembrane transport
C4K15_RS29565	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K15_RS29570	COG3842	ATPase activity
C4K15_RS29590	COG0174	glutamine synthetase
C4K15_RS29595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K15_RS29600	COG0174	glutamine synthetase
C4K15_RS29615	COG1116	anion transmembrane transporter activity
C4K15_RS29620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K15_RS29625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K15_RS29630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K15_RS29635	COG0431	NADPH-dependent FMN reductase
C4K15_RS29640	COG0450	alkyl hydroperoxide reductase
C4K15_RS29650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4K15_RS29650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K15_RS29655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K15_RS29665	COG1522	sequence-specific DNA binding
C4K15_RS29675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4K15_RS29685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K15_RS29685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K15_RS29690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K15_RS29705	COG0509	glycine decarboxylation via glycine cleavage system
C4K15_RS29710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K15_RS29715	COG1178	ABC-type Fe3 transport system permease component
C4K15_RS29725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K15_RS29730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K15_RS29735	COG0006	proline dipeptidase activity
C4K15_RS29740	COG3079	Belongs to the UPF0149 family
C4K15_RS29760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4K15_RS29770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K15_RS29775	COG0842	Transport permease protein
C4K15_RS29775	COG1129	ABC transporter
C4K15_RS29780	COG0842	Transport permease protein
C4K15_RS29790	COG0604	alcohol dehydrogenase
C4K15_RS29795	COG2271	Major facilitator Superfamily
C4K15_RS29810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4K15_RS29825	COG2186	Transcriptional regulator
C4K15_RS29830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS29835	COG0765	amino acid transport
C4K15_RS29840	COG0765	amino acid transport
C4K15_RS29845	COG1126	abc transporter atp-binding protein
C4K15_RS29850	COG0248	Ppx GppA phosphatase
C4K15_RS29855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4K15_RS29865	COG0586	Pfam SNARE associated Golgi protein
C4K15_RS29875	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4K15_RS29880	COG1671	Belongs to the UPF0178 family
C4K15_RS29885	COG0672	)-iron permease
C4K15_RS29890	COG1280	lysine exporter protein (LysE YggA)
C4K15_RS29900	COG0488	(ABC) transporter
C4K15_RS29925	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K15_RS29945	COG0181	hydroxymethylbilane synthase activity
C4K15_RS29955	COG0165	Argininosuccinate lyase
C4K15_RS29960	COG0625	glutathione transferase activity
C4K15_RS29975	COG3072	Adenylate cyclase
C4K15_RS29980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K15_RS29990	COG1965	Belongs to the frataxin family
C4K15_RS30000	COG0019	diaminopimelate decarboxylase activity
C4K15_RS30005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K15_RS30015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K15_RS30020	COG1011	Hydrolase
C4K15_RS30030	COG0432	Pfam Uncharacterised protein family UPF0047
C4K15_RS30035	COG0004	ammonium transporteR
C4K15_RS30040	COG0347	Belongs to the P(II) protein family
C4K15_RS30055	COG0529	Catalyzes the synthesis of activated sulfate
C4K15_RS30065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K15_RS30070	COG0574	Belongs to the PEP-utilizing enzyme family
C4K15_RS30070	COG3848	Pyruvate phosphate dikinase
C4K15_RS30075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K15_RS30080	COG1213	nucleotidyl transferase
C4K15_RS30085	COG0606	chelatase, subunit chli
C4K15_RS30130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K15_RS30170	COG0583	DNA-binding transcription factor activity
C4K15_RS30175	COG0534	Mate efflux family protein
C4K15_RS30190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K15_RS30195	COG0427	acetyl-CoA hydrolase
C4K15_RS30210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4K15_RS30215	COG0251	oxidation-reduction process
C4K15_RS30220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS30235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K15_RS30245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K15_RS30250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K15_RS30260	COG1012	belongs to the aldehyde dehydrogenase family
C4K15_RS30270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4K15_RS30275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4K15_RS30280	COG0747	negative chemotaxis
C4K15_RS30285	COG2003	Belongs to the UPF0758 family
C4K15_RS30290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4K15_RS30295	COG0756	dUTP diphosphatase activity
C4K15_RS30300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K15_RS30305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K15_RS30310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4K15_RS30315	COG0708	Exodeoxyribonuclease III
C4K15_RS30325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4K15_RS30330	COG1561	YicC-like family, N-terminal region
C4K15_RS30335	COG0194	GDP metabolic process
C4K15_RS30340	COG1758	RNA polymerase activity
C4K15_RS30345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K15_RS30370	COG0848	biopolymer transport protein
C4K15_RS30380	COG0583	DNA-binding transcription factor activity
C4K15_RS30385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4K15_RS30460	COG0515	serine threonine protein kinase
C4K15_RS30500	COG2204	response regulator
C4K15_RS30580	COG3161	chorismate lyase activity
C4K15_RS30585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4K15_RS30605	COG1253	flavin adenine dinucleotide binding
C4K15_RS30610	COG0739	heme binding
C4K15_RS30630	COG0704	Plays a role in the regulation of phosphate uptake
C4K15_RS30635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4K15_RS30640	COG0573	inorganic phosphate transmembrane transporter activity
C4K15_RS30655	COG0477	Major facilitator Superfamily
C4K15_RS30660	COG1607	acyl-coa hydrolase
C4K15_RS30690	COG0583	DNA-binding transcription factor activity
C4K15_RS30695	COG1027	Aspartate ammonia-lyase
C4K15_RS30705	COG1115	amino acid carrier protein
C4K15_RS30710	COG0252	asparaginase activity
C4K15_RS30765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K15_RS30770	COG0765	amino acid transport
C4K15_RS30785	COG5016	pyruvate
C4K15_RS30785	COG0511	ligase activity, forming carbon-carbon bonds
C4K15_RS30790	COG0439	Biotin carboxylase
C4K15_RS30795	COG0583	DNA-binding transcription factor activity
C4K15_RS30820	COG0210	DNA helicase
C4K15_RS30845	COG4651	solute:proton antiporter activity
C4K15_RS30845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K15_RS30850	COG1607	acyl-coa hydrolase
C4K15_RS30855	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4K15_RS30865	COG0523	cobalamin synthesis protein
C4K15_RS30890	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K15_RS30895	COG1469	GTP cyclohydrolase I activity
C4K15_RS30900	COG1121	(ABC) transporter
C4K15_RS30910	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4K15_RS30915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K15_RS30925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K15_RS30930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K15_RS30940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K15_RS30945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4K15_RS30950	COG2217	Heavy metal translocating P-type atpase
C4K15_RS30970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4K15_RS30975	COG2267	carboxylic ester hydrolase activity
C4K15_RS30980	COG2453	phosphatase
C4K15_RS30980	COG0671	phosphoesterase, PA-phosphatase related
C4K15_RS30995	COG4589	Belongs to the CDS family
C4K15_RS31000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K15_RS31010	COG1280	lysine exporter protein (LysE YggA)
C4K15_RS31015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K15_RS31020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K15_RS31020	COG2755	lipolytic protein G-D-S-L family
C4K15_RS31025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K15_RS31085	COG0625	glutathione transferase activity
C4K15_RS31090	COG0583	DNA-binding transcription factor activity
C4K15_RS31095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K15_RS31110	COG0494	nUDIX hydrolase
C4K15_RS31115	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K15_RS31130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K15_RS31135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K15_RS31140	COG0494	nUDIX hydrolase
C4K15_RS31155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K15_RS31160	COG1349	DNA-binding transcription factor activity
C4K15_RS31165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K15_RS31170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4K15_RS31175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4K15_RS31180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4K15_RS31185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4K15_RS31190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4K15_RS31195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4K15_RS31205	COG0356	it plays a direct role in the translocation of protons across the membrane
C4K15_RS31210	COG3312	ion transport
C4K15_RS31215	COG1475	DNA binding
C4K15_RS31220	COG1192	Involved in chromosome partitioning
C4K15_RS31225	COG0357	Ribosomal RNA small subunit methyltransferase G
C4K15_RS31230	COG0445	tRNA wobble uridine modification
C4K15_RS31240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K15_RS31245	COG0706	membrane insertase activity
C4K15_RS31250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4K15_RS31255	COG0594	ribonuclease P activity
C4K15_RS31260	COG0230	Belongs to the bacterial ribosomal protein bL34 family