locus-tag	class	description
JHW28_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHW28_RS00010	COG0592	DNA-directed DNA polymerase activity
JHW28_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHW28_RS00020	COG0187	DNA topoisomerase II activity
JHW28_RS00045	COG5002	protein histidine kinase activity
JHW28_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHW28_RS00060	COG0751	glycine-tRNA ligase activity
JHW28_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
JHW28_RS00070	COG2818	Glycosylase
JHW28_RS00090	COG0569	domain protein
JHW28_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHW28_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS00105	COG0242	peptide deformylase activity
JHW28_RS00115	COG0758	DNA mediated transformation
JHW28_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
JHW28_RS00130	COG0408	coproporphyrinogen oxidase activity
JHW28_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHW28_RS00150	COG3119	arylsulfatase activity
JHW28_RS00175	COG0159	tryptophan synthase activity
JHW28_RS00180	COG0133	tryptophan synthase activity
JHW28_RS00195	COG3360	Dodecin
JHW28_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS00210	COG1764	response to oxidative stress
JHW28_RS00240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JHW28_RS00245	COG0339	signal peptide processing
JHW28_RS00250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JHW28_RS00285	COG0659	secondary active sulfate transmembrane transporter activity
JHW28_RS00295	COG1565	acr, cog1565
JHW28_RS00295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHW28_RS00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHW28_RS00305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JHW28_RS00335	COG0109	protoheme IX farnesyltransferase activity
JHW28_RS00350	COG2011	ABC-type metal ion transport system permease component
JHW28_RS00355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHW28_RS00370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHW28_RS00375	COG1121	(ABC) transporter
JHW28_RS00380	COG0735	belongs to the Fur family
JHW28_RS00385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JHW28_RS00405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHW28_RS00410	COG3245	cytochrome
JHW28_RS00420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHW28_RS00435	COG3023	N-Acetylmuramoyl-L-alanine amidase
JHW28_RS00440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JHW28_RS00445	COG5002	protein histidine kinase activity
JHW28_RS00450	COG2204	response regulator
JHW28_RS00470	COG1301	dicarboxylic acid transport
JHW28_RS00475	COG0700	Nucleoside recognition
JHW28_RS00490	COG1127	ABC transporter
JHW28_RS00495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHW28_RS00505	COG0612	Peptidase, M16
JHW28_RS00510	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHW28_RS00515	COG0861	Integral membrane protein TerC family
JHW28_RS00520	COG2851	Citrate transporter
JHW28_RS00560	COG0427	acetyl-CoA hydrolase
JHW28_RS00580	COG0583	DNA-binding transcription factor activity
JHW28_RS00585	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS00635	COG3712	iron ion homeostasis
JHW28_RS00640	COG1595	DNA-templated transcription, initiation
JHW28_RS00645	COG0840	transmembrane signaling receptor activity
JHW28_RS00655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JHW28_RS00675	COG1802	Transcriptional regulator
JHW28_RS00685	COG5001	Diguanylate cyclase
JHW28_RS00685	COG3300	MHYT domain
JHW28_RS00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS00715	COG2175	clavaminate synthase activity
JHW28_RS00725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JHW28_RS00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS00740	COG2814	Major facilitator Superfamily
JHW28_RS00820	COG0529	Catalyzes the synthesis of activated sulfate
JHW28_RS00835	COG0330	HflC and HflK could
JHW28_RS00870	COG1289	transmembrane transporter activity
JHW28_RS00880	COG1566	PFAM secretion protein HlyD family protein
JHW28_RS00895	COG5339	Protein conserved in bacteria
JHW28_RS00900	COG0457	Tetratricopeptide repeat
JHW28_RS00905	COG1649	PFAM Uncharacterised BCR, COG1649
JHW28_RS00905	COG0726	polysaccharide deacetylase
JHW28_RS00910	COG1215	transferase activity, transferring glycosyl groups
JHW28_RS00920	COG1881	PFAM PEBP family protein
JHW28_RS00925	COG2304	oxidoreductase activity
JHW28_RS00930	COG1595	DNA-templated transcription, initiation
JHW28_RS01000	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW28_RS01010	COG0745	RESPONSE REGULATOR receiver
JHW28_RS01015	COG2199	diguanylate cyclase activity
JHW28_RS01035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JHW28_RS01045	COG4208	sulfate ABC transporter
JHW28_RS01050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JHW28_RS01085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS01090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS01115	COG4771	TonB-dependent receptor
JHW28_RS01170	COG2807	transmembrane transport
JHW28_RS01175	COG0590	tRNA wobble adenosine to inosine editing
JHW28_RS01185	COG0583	DNA-binding transcription factor activity
JHW28_RS01220	COG0765	amino acid transport
JHW28_RS01225	COG0765	amino acid transport
JHW28_RS01230	COG1126	abc transporter atp-binding protein
JHW28_RS01235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS01240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHW28_RS01265	COG2011	ABC-type metal ion transport system permease component
JHW28_RS01270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHW28_RS01295	COG1126	abc transporter atp-binding protein
JHW28_RS01300	COG0765	amino acid transport
JHW28_RS01305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS01310	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JHW28_RS01315	COG1045	serine acetyltransferase
JHW28_RS01320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHW28_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS01350	COG0583	DNA-binding transcription factor activity
JHW28_RS01365	COG1609	Transcriptional regulator
JHW28_RS01380	COG0667	Aldo Keto reductase
JHW28_RS01385	COG1487	ribonuclease activity
JHW28_RS01395	COG2175	clavaminate synthase activity
JHW28_RS01400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS01405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JHW28_RS01410	COG4521	taurine ABC transporter
JHW28_RS01415	COG2918	glutathione biosynthetic process
JHW28_RS01425	COG2183	response to ionizing radiation
JHW28_RS01435	COG2205	protein histidine kinase activity
JHW28_RS01440	COG0189	ligase activity
JHW28_RS01445	COG4067	protein conserved in archaea
JHW28_RS01445	COG0189	ligase activity
JHW28_RS01450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHW28_RS01460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JHW28_RS01465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JHW28_RS01505	COG0514	ATP-dependent DNA helicase (RecQ)
JHW28_RS01515	COG0824	Thioesterase
JHW28_RS01525	COG0243	molybdopterin cofactor binding
JHW28_RS01530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHW28_RS01540	COG1652	LysM domain
JHW28_RS01545	COG1011	Hydrolase
JHW28_RS01550	COG0494	nUDIX hydrolase
JHW28_RS01575	COG1091	dTDP-4-dehydrorhamnose reductase activity
JHW28_RS01585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JHW28_RS01595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW28_RS01610	COG2957	Belongs to the agmatine deiminase family
JHW28_RS01645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHW28_RS01650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHW28_RS01655	COG1845	cytochrome c oxidase, subunit III
JHW28_RS01660	COG1845	cytochrome c oxidase, subunit III
JHW28_RS01675	COG0655	NAD(P)H dehydrogenase (quinone) activity
JHW28_RS01725	COG0582	viral genome integration into host DNA
JHW28_RS01765	COG4215	(ABC) transporter
JHW28_RS01805	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JHW28_RS01810	COG1194	a g-specific adenine glycosylase
JHW28_RS01825	COG2223	nitrite transmembrane transporter activity
JHW28_RS01830	COG0131	Imidazoleglycerol-phosphate dehydratase
JHW28_RS01835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JHW28_RS01845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JHW28_RS01850	COG0107	imidazoleglycerol-phosphate synthase activity
JHW28_RS01860	COG2861	carbohydrate metabolic process
JHW28_RS01865	COG0793	Belongs to the peptidase S41A family
JHW28_RS01870	COG4942	peptidase
JHW28_RS01875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JHW28_RS01890	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHW28_RS01910	COG3852	Histidine kinase
JHW28_RS01950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHW28_RS01950	COG0301	tRNA thio-modification
JHW28_RS01955	COG1217	gtp-binding protein TYPA
JHW28_RS01965	COG0058	SHG alpha-glucan phosphorylase activity
JHW28_RS01970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JHW28_RS02005	COG0402	S-adenosylhomocysteine deaminase activity
JHW28_RS02010	COG2188	Transcriptional regulator
JHW28_RS02020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JHW28_RS02025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHW28_RS02035	COG4176	ABC-type proline glycine betaine transport system permease component
JHW28_RS02040	COG0517	IMP dehydrogenase activity
JHW28_RS02040	COG4175	Glycine betaine
JHW28_RS02045	COG2986	histidine ammonia-lyase
JHW28_RS02050	COG2986	histidine ammonia-lyase
JHW28_RS02055	COG1113	amino acid transport
JHW28_RS02060	COG1228	amidohydrolase
JHW28_RS02070	COG0596	Alpha beta hydrolase
JHW28_RS02075	COG1490	D-aminoacyl-tRNA deacylase activity
JHW28_RS02080	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
JHW28_RS02085	COG2943	transferase activity, transferring hexosyl groups
JHW28_RS02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS02095	COG0765	amino acid transport
JHW28_RS02105	COG0840	transmembrane signaling receptor activity
JHW28_RS02120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHW28_RS02125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHW28_RS02130	COG0140	phosphoribosyl-ATP diphosphatase activity
JHW28_RS02135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHW28_RS02140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHW28_RS02150	COG2226	methyltransferase
JHW28_RS02195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHW28_RS02200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHW28_RS02210	COG0018	arginyl-trna synthetase
JHW28_RS02220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JHW28_RS02225	COG0254	rRNA binding
JHW28_RS02235	COG0281	malic enzyme
JHW28_RS02270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHW28_RS02275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHW28_RS02285	COG0067	glutamate synthase
JHW28_RS02285	COG0069	glutamate synthase activity
JHW28_RS02285	COG0070	glutamate synthase
JHW28_RS02290	COG0493	'glutamate synthase
JHW28_RS02295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JHW28_RS02300	COG3111	PFAM Bacterial OB fold (BOF) protein
JHW28_RS02305	COG2814	Major facilitator Superfamily
JHW28_RS02310	COG0583	DNA-binding transcription factor activity
JHW28_RS02325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW28_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS02340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW28_RS02350	COG2226	methyltransferase
JHW28_RS02380	COG2986	histidine ammonia-lyase
JHW28_RS02405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW28_RS02425	COG1192	Involved in chromosome partitioning
JHW28_RS02430	COG3118	belongs to the thioredoxin family
JHW28_RS02435	COG4680	protein conserved in bacteria
JHW28_RS02445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JHW28_RS02450	COG3264	Mechanosensitive ion channel
JHW28_RS02450	COG1196	nuclear chromosome segregation
JHW28_RS02455	COG3263	regulation of cellular component size
JHW28_RS02475	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS02480	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JHW28_RS02480	COG0506	proline dehydrogenase activity
JHW28_RS02480	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JHW28_RS02485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHW28_RS02490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JHW28_RS02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW28_RS02515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JHW28_RS02520	COG0859	PFAM glycosyl transferase family 9
JHW28_RS02525	COG0859	PFAM glycosyl transferase family 9
JHW28_RS02530	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS02555	COG2192	nodulation
JHW28_RS02560	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS02585	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS02600	COG1132	(ABC) transporter
JHW28_RS02615	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JHW28_RS02615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JHW28_RS02625	COG0667	Aldo Keto reductase
JHW28_RS02645	COG1519	Transferase
JHW28_RS02650	COG1538	Outer membrane efflux protein
JHW28_RS02655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JHW28_RS02670	COG0494	nUDIX hydrolase
JHW28_RS02680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JHW28_RS02685	COG3150	esterase
JHW28_RS02720	COG0560	Phosphoserine phosphatase
JHW28_RS02720	COG3830	Belongs to the UPF0237 family
JHW28_RS02725	COG0688	phosphatidylethanolamine metabolic process
JHW28_RS02765	COG1162	GTPase activity
JHW28_RS02770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JHW28_RS02775	COG2860	membrane
JHW28_RS02785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JHW28_RS02785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHW28_RS02790	COG0802	atpase or kinase
JHW28_RS02795	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHW28_RS02800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JHW28_RS02805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHW28_RS02810	COG1923	regulation of RNA biosynthetic process
JHW28_RS02815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHW28_RS02820	COG0330	HflC and HflK could
JHW28_RS02825	COG0330	HflC and HflK could
JHW28_RS02830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JHW28_RS02835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHW28_RS02840	COG0840	transmembrane signaling receptor activity
JHW28_RS02845	COG1178	ABC-type Fe3 transport system permease component
JHW28_RS02850	COG1840	ABC-type Fe3 transport system, periplasmic component
JHW28_RS02865	COG0557	exoribonuclease II activity
JHW28_RS02870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHW28_RS02875	COG0360	Binds together with S18 to 16S ribosomal RNA
JHW28_RS02880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JHW28_RS02890	COG0359	binds to the 23S rRNA
JHW28_RS02895	COG0305	Participates in initiation and elongation during chromosome replication
JHW28_RS02900	COG1032	radical SAM domain protein
JHW28_RS02915	COG2307	Protein conserved in bacteria
JHW28_RS02915	COG2308	Evidence 4 Homologs of previously reported genes of
JHW28_RS02945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JHW28_RS02950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHW28_RS02955	COG0583	DNA-binding transcription factor activity
JHW28_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS02965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS02975	COG0559	Belongs to the binding-protein-dependent transport system permease family
JHW28_RS02995	COG4221	oxidoreductase activity
JHW28_RS03015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JHW28_RS03020	COG0830	nickel cation binding
JHW28_RS03025	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JHW28_RS03040	COG2982	Protein involved in outer membrane biogenesis
JHW28_RS03045	COG0583	DNA-binding transcription factor activity
JHW28_RS03050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHW28_RS03060	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JHW28_RS03065	COG0697	spore germination
JHW28_RS03070	COG2207	Transcriptional regulator
JHW28_RS03085	COG0443	Heat shock 70 kDa protein
JHW28_RS03090	COG0484	heat shock protein binding
JHW28_RS03095	COG0789	Transcriptional regulator
JHW28_RS03105	COG0804	urea catabolic process
JHW28_RS03110	COG0832	Belongs to the urease beta subunit family
JHW28_RS03125	COG0831	urea catabolic process
JHW28_RS03130	COG0829	nickel cation binding
JHW28_RS03140	COG0411	ABC transporter
JHW28_RS03155	COG0683	leucine binding
JHW28_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW28_RS03170	COG1120	ATPase activity
JHW28_RS03210	COG3657	addiction module killer protein
JHW28_RS03220	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JHW28_RS03230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW28_RS03255	COG2095	MarC family integral membrane protein
JHW28_RS03265	COG0151	Belongs to the GarS family
JHW28_RS03270	COG0138	bifunctional purine biosynthesis protein purh
JHW28_RS03280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHW28_RS03290	COG2264	protein methyltransferase activity
JHW28_RS03305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHW28_RS03335	COG0023	Translation Initiation Factor
JHW28_RS03340	COG1166	arginine decarboxylase activity
JHW28_RS03345	COG0534	Mate efflux family protein
JHW28_RS03350	COG2373	Large extracellular alpha-helical protein
JHW28_RS03360	COG4953	penicillin-binding protein 1C
JHW28_RS03370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW28_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS03495	COG2217	Heavy metal translocating P-type atpase
JHW28_RS03525	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JHW28_RS03530	COG0583	DNA-binding transcription factor activity
JHW28_RS03535	COG0477	Major facilitator Superfamily
JHW28_RS03540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHW28_RS03555	COG0387	Pfam Sodium calcium exchanger
JHW28_RS03590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHW28_RS03610	COG0811	peptide transport
JHW28_RS03615	COG1079	Belongs to the binding-protein-dependent transport system permease family
JHW28_RS03620	COG4603	Belongs to the binding-protein-dependent transport system permease family
JHW28_RS03625	COG3845	ABC transporter
JHW28_RS03635	COG1309	transcriptional regulator
JHW28_RS03640	COG2233	PERMEase
JHW28_RS03685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JHW28_RS03690	COG1074	ATP-dependent DNA helicase activity
JHW28_RS03695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHW28_RS03700	COG1126	abc transporter atp-binding protein
JHW28_RS03705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS03725	COG2199	diguanylate cyclase activity
JHW28_RS03770	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
JHW28_RS03775	COG3483	tryptophan 2,3-dioxygenase activity
JHW28_RS03780	COG1113	amino acid transport
JHW28_RS03785	COG0543	2 iron, 2 sulfur cluster binding
JHW28_RS03785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW28_RS03790	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
JHW28_RS03795	COG4638	Rieske (2fe-2S)
JHW28_RS03805	COG1522	sequence-specific DNA binding
JHW28_RS03815	COG1113	amino acid transport
JHW28_RS03820	COG0583	DNA-binding transcription factor activity
JHW28_RS03835	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHW28_RS03840	COG0583	DNA-binding transcription factor activity
JHW28_RS03855	COG2610	gluconate transmembrane transporter activity
JHW28_RS03865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JHW28_RS03890	COG0840	transmembrane signaling receptor activity
JHW28_RS03930	COG1309	transcriptional regulator
JHW28_RS03955	COG0583	DNA-binding transcription factor activity
JHW28_RS03980	COG1204	response to ionizing radiation
JHW28_RS04020	COG0247	lactate metabolic process
JHW28_RS04025	COG1620	l-lactate permease
JHW28_RS04030	COG2186	Transcriptional regulator
JHW28_RS04035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHW28_RS04040	COG0733	neurotransmitter:sodium symporter activity
JHW28_RS04050	COG2914	Belongs to the UPF0125 (RnfH) family
JHW28_RS04055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW28_RS04065	COG0497	DNA recombination
JHW28_RS04070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHW28_RS04075	COG0443	Heat shock 70 kDa protein
JHW28_RS04080	COG0484	heat shock protein binding
JHW28_RS04085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHW28_RS04090	COG0505	Belongs to the CarA family
JHW28_RS04095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHW28_RS04100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW28_RS04115	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JHW28_RS04125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JHW28_RS04130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHW28_RS04135	COG0149	triose-phosphate isomerase activity
JHW28_RS04140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHW28_RS04160	COG0195	Participates in both transcription termination and antitermination
JHW28_RS04165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JHW28_RS04170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHW28_RS04175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHW28_RS04180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHW28_RS04185	COG1185	polyribonucleotide nucleotidyltransferase activity
JHW28_RS04215	COG3023	N-Acetylmuramoyl-L-alanine amidase
JHW28_RS04230	COG0084	hydrolase, TatD family'
JHW28_RS04235	COG1609	Transcriptional regulator
JHW28_RS04240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHW28_RS04240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW28_RS04245	COG1105	Belongs to the carbohydrate kinase PfkB family
JHW28_RS04250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JHW28_RS04250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW28_RS04250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW28_RS04265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHW28_RS04270	COG4774	siderophore transport
JHW28_RS04275	COG3128	pkhd-type hydroxylase
JHW28_RS04285	COG0019	diaminopimelate decarboxylase activity
JHW28_RS04310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHW28_RS04320	COG4608	Belongs to the ABC transporter superfamily
JHW28_RS04325	COG0444	Belongs to the ABC transporter superfamily
JHW28_RS04330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW28_RS04335	COG0601	transmembrane transport
JHW28_RS04340	COG0747	negative chemotaxis
JHW28_RS04350	COG0747	negative chemotaxis
JHW28_RS04355	COG0747	negative chemotaxis
JHW28_RS04365	COG1917	Cupin 2, conserved barrel domain protein
JHW28_RS04365	COG1396	sequence-specific DNA binding
JHW28_RS04380	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
JHW28_RS04385	COG4178	(ABC) transporter
JHW28_RS04390	COG2186	Transcriptional regulator
JHW28_RS04405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW28_RS04415	COG2271	Major facilitator Superfamily
JHW28_RS04420	COG2721	sulfolactate sulfo-lyase activity
JHW28_RS04430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW28_RS04440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHW28_RS04445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JHW28_RS04450	COG0154	amidase activity
JHW28_RS04455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JHW28_RS04460	COG1077	Cell shape determining protein MreB Mrl
JHW28_RS04465	COG1792	Involved in formation and maintenance of cell shape
JHW28_RS04475	COG0424	maF-like protein
JHW28_RS04480	COG1530	ribonuclease E activity
JHW28_RS04490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHW28_RS04495	COG0312	modulator of DNA gyrase
JHW28_RS04500	COG3028	Belongs to the UPF0307 family
JHW28_RS04505	COG0312	modulator of DNA gyrase
JHW28_RS04540	COG1660	Displays ATPase and GTPase activities
JHW28_RS04555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JHW28_RS04560	COG1137	ATPase activity
JHW28_RS04565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JHW28_RS04575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JHW28_RS04585	COG1127	ABC transporter
JHW28_RS04590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHW28_RS04595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHW28_RS04615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHW28_RS04620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JHW28_RS04625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JHW28_RS04630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHW28_RS04635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHW28_RS04645	COG0175	sulfate reduction
JHW28_RS04655	COG0204	Acyl-transferase
JHW28_RS04660	COG0280	phosphate acetyltransferase
JHW28_RS04660	COG0857	belongs to the CobB CobQ family
JHW28_RS04675	COG0386	Belongs to the glutathione peroxidase family
JHW28_RS04690	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JHW28_RS04695	COG0492	ferredoxin-NADP+ reductase activity
JHW28_RS04710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHW28_RS04715	COG0302	gtp cyclohydrolase
JHW28_RS04730	COG0789	Transcriptional regulator
JHW28_RS04740	COG1366	Belongs to the anti-sigma-factor antagonist family
JHW28_RS04750	COG0583	DNA-binding transcription factor activity
JHW28_RS04755	COG1380	Effector of murein hydrolase LrgA
JHW28_RS04760	COG1346	cytolysis
JHW28_RS04770	COG0596	Alpha beta hydrolase
JHW28_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS04795	COG2909	trisaccharide binding
JHW28_RS04805	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JHW28_RS04810	COG0179	Fumarylacetoacetate (FAA) hydrolase
JHW28_RS04830	COG2226	methyltransferase
JHW28_RS04845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JHW28_RS04875	COG0814	amino acid
JHW28_RS04880	COG1760	l-serine dehydratase
JHW28_RS04885	COG0583	DNA-binding transcription factor activity
JHW28_RS04895	COG4772	TonB-dependent receptor
JHW28_RS04900	COG3712	iron ion homeostasis
JHW28_RS04905	COG1595	DNA-templated transcription, initiation
JHW28_RS04925	COG2027	D-alanyl-D-alanine carboxypeptidase
JHW28_RS04935	COG0697	spore germination
JHW28_RS04940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW28_RS04945	COG0583	DNA-binding transcription factor activity
JHW28_RS04965	COG1566	PFAM secretion protein HlyD family protein
JHW28_RS04985	COG0300	oxidoreductase activity
JHW28_RS05000	COG2184	nucleotidyltransferase activity
JHW28_RS05010	COG0662	Cupin 2, conserved barrel domain protein
JHW28_RS05010	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
JHW28_RS05025	COG1696	Membrane protein involved in D-alanine export
JHW28_RS05040	COG3420	alginic acid biosynthetic process
JHW28_RS05050	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JHW28_RS05055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS05060	COG1215	transferase activity, transferring glycosyl groups
JHW28_RS05070	COG3022	response to hydroperoxide
JHW28_RS05080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JHW28_RS05085	COG0315	cyclic pyranopterin monophosphate synthase activity
JHW28_RS05090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHW28_RS05100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS05120	COG0513	Belongs to the DEAD box helicase family
JHW28_RS05130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS05135	COG4597	amino acid ABC transporter
JHW28_RS05140	COG0765	amino acid transport
JHW28_RS05145	COG1126	abc transporter atp-binding protein
JHW28_RS05150	COG2944	sequence-specific DNA binding
JHW28_RS05160	COG2186	Transcriptional regulator
JHW28_RS05165	COG2807	transmembrane transport
JHW28_RS05175	COG2827	Endonuclease containing a URI domain
JHW28_RS05195	COG3081	Nucleoid-associated protein
JHW28_RS05205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JHW28_RS05210	COG0525	valine-tRNA ligase activity
JHW28_RS05225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHW28_RS05230	COG0795	lipopolysaccharide-transporting ATPase activity
JHW28_RS05235	COG0795	lipopolysaccharide-transporting ATPase activity
JHW28_RS05240	COG0481	GTPase activity
JHW28_RS05245	COG0681	Belongs to the peptidase S26 family
JHW28_RS05255	COG0571	ribonuclease III activity
JHW28_RS05260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHW28_RS05265	COG1381	Involved in DNA repair and RecF pathway recombination
JHW28_RS05270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JHW28_RS05275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHW28_RS05280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JHW28_RS05280	COG0047	phosphoribosylformylglycinamidine synthase activity
JHW28_RS05290	COG1263	PTS System
JHW28_RS05290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW28_RS05290	COG2190	(PTS) system
JHW28_RS05295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW28_RS05295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHW28_RS05300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHW28_RS05305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHW28_RS05310	COG2188	Transcriptional regulator
JHW28_RS05325	COG0494	nUDIX hydrolase
JHW28_RS05345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JHW28_RS05350	COG0477	Major facilitator Superfamily
JHW28_RS05355	COG4536	flavin adenine dinucleotide binding
JHW28_RS05365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHW28_RS05370	COG0228	four-way junction DNA binding
JHW28_RS05375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHW28_RS05380	COG0336	Belongs to the RNA methyltransferase TrmD family
JHW28_RS05385	COG0335	large ribosomal subunit rRNA binding
JHW28_RS05390	COG1607	acyl-coa hydrolase
JHW28_RS05400	COG4974	Belongs to the 'phage' integrase family
JHW28_RS05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS05420	COG2205	protein histidine kinase activity
JHW28_RS05430	COG2197	response regulator
JHW28_RS05450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JHW28_RS05465	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS05470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
JHW28_RS05500	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS05505	COG1177	transmembrane transport
JHW28_RS05510	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW28_RS05515	COG3842	ATPase activity
JHW28_RS05520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHW28_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS05530	COG0583	DNA-binding transcription factor activity
JHW28_RS05550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHW28_RS05550	COG0457	Tetratricopeptide repeat
JHW28_RS05565	COG2201	protein-glutamate methylesterase activity
JHW28_RS05570	COG2203	Gaf domain
JHW28_RS05570	COG4251	negative regulation of phosphorylation
JHW28_RS05570	COG3706	GGDEF domain
JHW28_RS05570	COG5001	Diguanylate cyclase
JHW28_RS05580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHW28_RS05600	COG1073	alpha beta
JHW28_RS05625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JHW28_RS05630	COG0563	adenylate kinase activity
JHW28_RS05635	COG1214	PFAM Peptidase M22, glycoprotease
JHW28_RS05645	COG1801	Protein of unknown function DUF72
JHW28_RS05660	COG0742	ribosomal rna small subunit methyltransferase
JHW28_RS05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS05690	COG2937	Belongs to the GPAT DAPAT family
JHW28_RS05705	COG2226	methyltransferase
JHW28_RS05710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHW28_RS05720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JHW28_RS05730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHW28_RS05735	COG2171	N-acyltransferase activity
JHW28_RS05740	COG1393	Belongs to the ArsC family
JHW28_RS05745	COG0025	NhaP-type Na H and K H
JHW28_RS05750	COG0436	Aminotransferase
JHW28_RS05755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JHW28_RS05760	COG0024	Methionine aminopeptidase
JHW28_RS05765	COG0052	Belongs to the universal ribosomal protein uS2 family
JHW28_RS05770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHW28_RS05775	COG0528	UMP kinase activity
JHW28_RS05780	COG0233	cytoplasmic translational termination
JHW28_RS05785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JHW28_RS05795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHW28_RS05815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW28_RS05820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHW28_RS05825	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW28_RS05830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW28_RS05835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHW28_RS05840	COG0587	DNA-directed DNA polymerase activity
JHW28_RS05845	COG0825	malonyl-CoA metabolic process
JHW28_RS05850	COG0037	tRNA processing
JHW28_RS05855	COG0504	CTP synthase activity
JHW28_RS05860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JHW28_RS05865	COG0148	phosphopyruvate hydratase activity
JHW28_RS05875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHW28_RS05885	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JHW28_RS05890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JHW28_RS05895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHW28_RS05900	COG0585	pseudouridine synthase activity
JHW28_RS05905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JHW28_RS05910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JHW28_RS05930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHW28_RS05955	COG3023	N-Acetylmuramoyl-L-alanine amidase
JHW28_RS06050	COG4386	tail sheath protein
JHW28_RS06085	COG4381	Mu-like prophage protein gp46
JHW28_RS06130	COG3179	chitinase
JHW28_RS06140	COG1546	Belongs to the CinA family
JHW28_RS06145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHW28_RS06150	COG2137	regulation of response to DNA damage stimulus
JHW28_RS06170	COG3148	PFAM DTW domain containing protein
JHW28_RS06185	COG0583	DNA-binding transcription factor activity
JHW28_RS06205	COG4807	Protein conserved in bacteria
JHW28_RS06210	COG1187	pseudouridine synthase activity
JHW28_RS06220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHW28_RS06225	COG3158	transport of potassium into the cell
JHW28_RS06235	COG0392	lysyltransferase activity
JHW28_RS06235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JHW28_RS06250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHW28_RS06260	COG0442	prolyl-tRNA aminoacylation
JHW28_RS06285	COG1278	Cold shock
JHW28_RS06290	COG0717	Belongs to the dCTP deaminase family
JHW28_RS06325	COG2366	antibiotic biosynthetic process
JHW28_RS06330	COG0625	glutathione transferase activity
JHW28_RS06340	COG0653	protein targeting
JHW28_RS06350	COG3012	SEC-C Motif Domain Protein
JHW28_RS06385	COG1199	ATP-dependent helicase activity
JHW28_RS06400	COG2885	chlorophyll binding
JHW28_RS06405	COG0259	pyridoxamine-phosphate oxidase activity
JHW28_RS06420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHW28_RS06430	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JHW28_RS06445	COG0583	DNA-binding transcription factor activity
JHW28_RS06460	COG3220	belongs to the UPF0276 family
JHW28_RS06505	COG2084	Dehydrogenase
JHW28_RS06515	COG0727	PFAM Uncharacterised protein family (UPF0153)
JHW28_RS06520	COG2271	Major facilitator Superfamily
JHW28_RS06525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHW28_RS06540	COG0306	phosphate transporter
JHW28_RS06555	COG1414	Transcriptional regulator
JHW28_RS06560	COG2814	Major facilitator Superfamily
JHW28_RS06565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JHW28_RS06570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JHW28_RS06575	COG0183	Belongs to the thiolase family
JHW28_RS06580	COG3485	protocatechuate 3,4-dioxygenase
JHW28_RS06585	COG3485	protocatechuate 3,4-dioxygenase
JHW28_RS06590	COG0477	Major facilitator Superfamily
JHW28_RS06600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JHW28_RS06605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW28_RS06625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS06640	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS06645	COG2814	Major facilitator Superfamily
JHW28_RS06685	COG1473	amidohydrolase
JHW28_RS06695	COG0154	amidase activity
JHW28_RS06720	COG1704	LemA family
JHW28_RS06725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JHW28_RS06740	COG0697	spore germination
JHW28_RS06745	COG0693	protein deglycase activity
JHW28_RS06760	COG1629	transport
JHW28_RS06770	COG1595	DNA-templated transcription, initiation
JHW28_RS06775	COG3422	double-strand break repair
JHW28_RS06780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW28_RS06785	COG0235	Class ii aldolase
JHW28_RS06790	COG1396	sequence-specific DNA binding
JHW28_RS06800	COG1454	alcohol dehydrogenase
JHW28_RS06865	COG3938	Belongs to the proline racemase family
JHW28_RS06870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW28_RS06875	COG0531	amino acid
JHW28_RS06885	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JHW28_RS06905	COG0583	DNA-binding transcription factor activity
JHW28_RS06910	COG5001	Diguanylate cyclase
JHW28_RS06920	COG3468	outer membrane autotransporter barrel domain protein
JHW28_RS06930	COG2267	carboxylic ester hydrolase activity
JHW28_RS06960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHW28_RS07005	COG0354	folic acid binding
JHW28_RS07010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JHW28_RS07040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHW28_RS07050	COG0425	Belongs to the sulfur carrier protein TusA family
JHW28_RS07060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JHW28_RS07070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW28_RS07075	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JHW28_RS07080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JHW28_RS07085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JHW28_RS07105	COG2197	response regulator
JHW28_RS07115	COG3121	Chaperone
JHW28_RS07120	COG3188	usher protein
JHW28_RS07125	COG3121	Chaperone
JHW28_RS07130	COG2831	hemolysin activation secretion protein
JHW28_RS07135	COG3210	domain, Protein
JHW28_RS07165	COG2807	transmembrane transport
JHW28_RS07170	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
JHW28_RS07180	COG0583	DNA-binding transcription factor activity
JHW28_RS07190	COG2194	sulfuric ester hydrolase activity
JHW28_RS07205	COG3100	YcgL domain-containing protein
JHW28_RS07210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW28_RS07220	COG2983	Belongs to the UPF0260 family
JHW28_RS07270	COG0121	glutamine amidotransferase
JHW28_RS07280	COG0583	DNA-binding transcription factor activity
JHW28_RS07285	COG2814	Major facilitator Superfamily
JHW28_RS07290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHW28_RS07295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHW28_RS07300	COG1984	allophanate hydrolase subunit 2
JHW28_RS07310	COG0542	response to heat
JHW28_RS07320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHW28_RS07350	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
JHW28_RS07355	COG1643	Atp-dependent helicase
JHW28_RS07365	COG1595	DNA-templated transcription, initiation
JHW28_RS07380	COG0814	amino acid
JHW28_RS07400	COG4638	Rieske (2fe-2S)
JHW28_RS07415	COG0477	Major facilitator Superfamily
JHW28_RS07420	COG0583	DNA-binding transcription factor activity
JHW28_RS07430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHW28_RS07435	COG1132	(ABC) transporter
JHW28_RS07445	COG2267	carboxylic ester hydrolase activity
JHW28_RS07460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHW28_RS07470	COG0668	transmembrane transport
JHW28_RS07475	COG0513	Belongs to the DEAD box helicase family
JHW28_RS07535	COG1953	Uracil, thiamine, allantoin
JHW28_RS07540	COG0697	spore germination
JHW28_RS07550	COG0583	DNA-binding transcription factor activity
JHW28_RS07560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHW28_RS07565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHW28_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS07620	COG5001	Diguanylate cyclase
JHW28_RS07620	COG3300	MHYT domain
JHW28_RS07630	COG2832	Protein of unknown function (DUF454)
JHW28_RS07655	COG1752	Esterase of the alpha-beta hydrolase superfamily
JHW28_RS07670	COG2207	Transcriptional regulator
JHW28_RS07695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHW28_RS07715	COG0745	RESPONSE REGULATOR receiver
JHW28_RS07725	COG2350	Protein conserved in bacteria
JHW28_RS07730	COG2917	probably involved in intracellular septation
JHW28_RS07735	COG0613	PHP domain protein
JHW28_RS07740	COG0009	L-threonylcarbamoyladenylate synthase
JHW28_RS07745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JHW28_RS07750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JHW28_RS07770	COG1113	amino acid transport
JHW28_RS07795	COG2154	pterin-4-alpha-carbinolamine dehydratase
JHW28_RS07810	COG4786	Flagellar basal body rod
JHW28_RS07820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHW28_RS07825	COG1706	bacterial-type flagellum-dependent cell motility
JHW28_RS07835	COG1256	bacterial-type flagellum assembly
JHW28_RS07845	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS07845	COG1216	Glycosyl transferase, family 2
JHW28_RS07850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JHW28_RS07860	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JHW28_RS07885	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS07885	COG1216	Glycosyl transferase, family 2
JHW28_RS07890	COG1086	Polysaccharide biosynthesis protein
JHW28_RS07895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHW28_RS07900	COG1083	cytidylyl-transferase
JHW28_RS07910	COG2089	acid synthase
JHW28_RS07930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHW28_RS07940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHW28_RS07970	COG1677	Flagellar hook-basal body complex protein FliE
JHW28_RS08005	COG0745	RESPONSE REGULATOR receiver
JHW28_RS08085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JHW28_RS08090	COG2198	Histidine kinase
JHW28_RS08090	COG0643	Histidine kinase
JHW28_RS08090	COG0784	Response regulator, receiver
JHW28_RS08095	COG2201	protein-glutamate methylesterase activity
JHW28_RS08100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHW28_RS08110	COG1192	Involved in chromosome partitioning
JHW28_RS08120	COG0835	chemotaxis
JHW28_RS08140	COG4133	protoheme IX ABC transporter activity
JHW28_RS08160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JHW28_RS08165	COG1138	Cytochrome C-type biogenesis protein
JHW28_RS08175	COG3088	subunit of a heme lyase
JHW28_RS08195	COG0583	DNA-binding transcription factor activity
JHW28_RS08200	COG2814	Major facilitator Superfamily
JHW28_RS08220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHW28_RS08225	COG4413	Urea transporter
JHW28_RS08230	COG0469	pyruvate kinase activity
JHW28_RS08240	COG2084	Dehydrogenase
JHW28_RS08245	COG3622	Belongs to the hyi family
JHW28_RS08250	COG3960	tartronate-semialdehyde synthase activity
JHW28_RS08260	COG1309	transcriptional regulator
JHW28_RS08265	COG2354	Protein conserved in bacteria
JHW28_RS08270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW28_RS08285	COG1834	amidinotransferase
JHW28_RS08295	COG2192	nodulation
JHW28_RS08305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHW28_RS08310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS08330	COG2853	Lipoprotein
JHW28_RS08350	COG2113	Glycine betaine
JHW28_RS08355	COG3162	membrane
JHW28_RS08360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHW28_RS08370	COG2009	succinate dehydrogenase
JHW28_RS08375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JHW28_RS08380	COG1053	succinate dehydrogenase
JHW28_RS08400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW28_RS08405	COG0045	succinate-CoA ligase (ADP-forming) activity
JHW28_RS08445	COG0326	Molecular chaperone. Has ATPase activity
JHW28_RS08455	COG0626	cystathionine gamma-synthase activity
JHW28_RS08465	COG1741	Belongs to the pirin family
JHW28_RS08495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHW28_RS08500	COG5002	protein histidine kinase activity
JHW28_RS08500	COG2205	protein histidine kinase activity
JHW28_RS08500	COG0784	Response regulator, receiver
JHW28_RS08510	COG4771	TonB-dependent receptor
JHW28_RS08515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHW28_RS08525	COG2062	phosphohistidine phosphatase, SixA
JHW28_RS08530	COG1022	Amp-dependent synthetase and ligase
JHW28_RS08550	COG0625	glutathione transferase activity
JHW28_RS08560	COG0628	permease
JHW28_RS08575	COG0284	orotidine-5'-phosphate decarboxylase activity
JHW28_RS08580	COG2130	NADP-dependent
JHW28_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS08590	COG0840	transmembrane signaling receptor activity
JHW28_RS08620	COG2814	Major facilitator Superfamily
JHW28_RS08625	COG3210	domain, Protein
JHW28_RS08635	COG2205	protein histidine kinase activity
JHW28_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS08655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHW28_RS08670	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS08680	COG0625	glutathione transferase activity
JHW28_RS08685	COG1131	(ABC) transporter
JHW28_RS08690	COG0842	Transport permease protein
JHW28_RS08705	COG0811	peptide transport
JHW28_RS08710	COG0848	biopolymer transport protein
JHW28_RS08715	COG1663	tetraacyldisaccharide 4'-kinase activity
JHW28_RS08720	COG2835	tetraacyldisaccharide 4'-kinase activity
JHW28_RS08725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JHW28_RS08730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JHW28_RS08735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JHW28_RS08745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW28_RS08750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JHW28_RS08750	COG3608	succinylglutamate desuccinylase aspartoacylase
JHW28_RS08760	COG1530	ribonuclease E activity
JHW28_RS08770	COG0546	phosphoglycolate phosphatase activity
JHW28_RS08775	COG0616	signal peptide processing
JHW28_RS08775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHW28_RS08780	COG0424	maF-like protein
JHW28_RS08790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JHW28_RS08795	COG0416	fatty acid biosynthetic process
JHW28_RS08810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW28_RS08815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW28_RS08825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHW28_RS08830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHW28_RS08840	COG0084	hydrolase, TatD family'
JHW28_RS08855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHW28_RS08870	COG2188	Transcriptional regulator
JHW28_RS08875	COG1397	ADP-ribosylglycohydrolase
JHW28_RS08885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW28_RS08915	COG1418	mRNA catabolic process
JHW28_RS08925	COG3734	2-keto-3-deoxy-galactonokinase
JHW28_RS08930	COG0800	Aldolase
JHW28_RS08935	COG4948	Mandelate Racemase Muconate Lactonizing
JHW28_RS08940	COG2271	Major facilitator Superfamily
JHW28_RS08945	COG1414	Transcriptional regulator
JHW28_RS08950	COG1064	alcohol dehydrogenase
JHW28_RS08955	COG2207	Transcriptional regulator
JHW28_RS08985	COG2885	chlorophyll binding
JHW28_RS08985	COG3047	cAMP biosynthetic process
JHW28_RS08990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW28_RS09025	COG0183	Belongs to the thiolase family
JHW28_RS09030	COG1024	Enoyl-CoA hydratase
JHW28_RS09030	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW28_RS09035	COG0519	Catalyzes the synthesis of GMP from XMP
JHW28_RS09035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHW28_RS09040	COG0598	Magnesium transport protein CorA
JHW28_RS09045	COG0204	Acyl-transferase
JHW28_RS09095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW28_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS09105	COG0583	DNA-binding transcription factor activity
JHW28_RS09115	COG1953	Uracil, thiamine, allantoin
JHW28_RS09125	COG0560	Phosphoserine phosphatase
JHW28_RS09145	COG4067	protein conserved in archaea
JHW28_RS09145	COG0189	ligase activity
JHW28_RS09150	COG1802	Transcriptional regulator
JHW28_RS09160	COG0372	Belongs to the citrate synthase family
JHW28_RS09175	COG2079	MmgE PrpD family protein
JHW28_RS09180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHW28_RS09195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHW28_RS09210	COG0668	transmembrane transport
JHW28_RS09220	COG3047	cAMP biosynthetic process
JHW28_RS09220	COG2885	chlorophyll binding
JHW28_RS09225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHW28_RS09230	COG0243	molybdopterin cofactor binding
JHW28_RS09235	COG2146	nitrite reductase [NAD(P)H] activity
JHW28_RS09240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW28_RS09250	COG2223	nitrite transmembrane transporter activity
JHW28_RS09255	COG3707	response regulator
JHW28_RS09260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS09265	COG0167	dihydroorotate dehydrogenase activity
JHW28_RS09270	COG3130	regulation of translation
JHW28_RS09275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHW28_RS09275	COG0116	Belongs to the methyltransferase superfamily
JHW28_RS09285	COG2027	D-alanyl-D-alanine carboxypeptidase
JHW28_RS09290	COG3171	Protein conserved in bacteria
JHW28_RS09295	COG3135	benzoate transporter
JHW28_RS09300	COG1802	Transcriptional regulator
JHW28_RS09305	COG0402	S-adenosylhomocysteine deaminase activity
JHW28_RS09330	COG1196	nuclear chromosome segregation
JHW28_RS09335	COG3115	cell septum assembly
JHW28_RS09340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHW28_RS09365	COG0697	spore germination
JHW28_RS09390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JHW28_RS09395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHW28_RS09400	COG2130	NADP-dependent
JHW28_RS09405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHW28_RS09410	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS09415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHW28_RS09420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHW28_RS09440	COG2217	Heavy metal translocating P-type atpase
JHW28_RS09450	COG0348	domain, Protein
JHW28_RS09465	COG2010	Cytochrome c
JHW28_RS09480	COG3278	Belongs to the heme-copper respiratory oxidase family
JHW28_RS09485	COG2010	Cytochrome c
JHW28_RS09500	COG3278	Belongs to the heme-copper respiratory oxidase family
JHW28_RS09510	COG0840	transmembrane signaling receptor activity
JHW28_RS09525	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JHW28_RS09530	COG0425	Belongs to the sulfur carrier protein TusA family
JHW28_RS09540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW28_RS09550	COG1132	(ABC) transporter
JHW28_RS09555	COG0741	lytic transglycosylase activity
JHW28_RS09560	COG0488	(ABC) transporter
JHW28_RS09565	COG0589	response to stress
JHW28_RS09575	COG1024	Enoyl-CoA hydratase
JHW28_RS09575	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW28_RS09580	COG0183	Belongs to the thiolase family
JHW28_RS09625	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHW28_RS09630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHW28_RS09640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHW28_RS09655	COG1477	protein flavinylation
JHW28_RS09660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW28_RS09665	COG0584	glycerophosphoryl diester phosphodiesterase
JHW28_RS09675	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHW28_RS09680	COG1136	(ABC) transporter
JHW28_RS09685	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHW28_RS09705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHW28_RS09705	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHW28_RS09715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW28_RS09720	COG2853	Lipoprotein
JHW28_RS09730	COG2204	response regulator
JHW28_RS09740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHW28_RS09745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHW28_RS09750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHW28_RS09755	COG0583	DNA-binding transcription factor activity
JHW28_RS09765	COG2203	Gaf domain
JHW28_RS09765	COG3706	GGDEF domain
JHW28_RS09765	COG4251	negative regulation of phosphorylation
JHW28_RS09765	COG5001	Diguanylate cyclase
JHW28_RS09790	COG2233	PERMEase
JHW28_RS09820	COG0556	nucleotide-excision repair
JHW28_RS09835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHW28_RS09865	COG0596	Alpha beta hydrolase
JHW28_RS09875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHW28_RS09890	COG2214	Heat shock protein DnaJ domain protein
JHW28_RS09895	COG0443	Heat shock 70 kDa protein
JHW28_RS09910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JHW28_RS09915	COG0066	3-isopropylmalate dehydratase activity
JHW28_RS09920	COG0473	3-isopropylmalate dehydrogenase activity
JHW28_RS09950	COG0135	phosphoribosylanthranilate isomerase activity
JHW28_RS09955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHW28_RS09960	COG0285	dihydrofolate synthase activity
JHW28_RS09965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHW28_RS09970	COG1286	toxin biosynthetic process
JHW28_RS10005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS10030	COG3397	chitin binding
JHW28_RS10035	COG3469	chitinase activity
JHW28_RS10050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JHW28_RS10085	COG1129	ABC transporter
JHW28_RS10090	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW28_RS10095	COG1609	Transcriptional regulator
JHW28_RS10100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW28_RS10105	COG1869	D-ribose catabolic process
JHW28_RS10130	COG1278	Cold shock
JHW28_RS10140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHW28_RS10145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JHW28_RS10150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JHW28_RS10155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JHW28_RS10160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JHW28_RS10165	COG0072	phenylalanine-tRNA ligase activity
JHW28_RS10170	COG0776	regulation of translation
JHW28_RS10190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHW28_RS10510	COG3539	Fimbrial protein
JHW28_RS10550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW28_RS10585	COG1309	transcriptional regulator
JHW28_RS10590	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW28_RS10600	COG3284	Transcriptional regulator
JHW28_RS10605	COG3199	ATP-NAD kinase
JHW28_RS10610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JHW28_RS10615	COG0022	dehydrogenase e1 component
JHW28_RS10625	COG1063	alcohol dehydrogenase
JHW28_RS10645	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS10650	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS10655	COG4191	Histidine kinase
JHW28_RS10660	COG4566	intracellular signal transduction
JHW28_RS10670	COG1598	PFAM Uncharacterised protein family UPF0150
JHW28_RS10705	COG0450	alkyl hydroperoxide reductase
JHW28_RS10740	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHW28_RS10745	COG3657	addiction module killer protein
JHW28_RS10750	COG5383	Protein conserved in bacteria
JHW28_RS10755	COG3706	GGDEF domain
JHW28_RS10780	COG0531	amino acid
JHW28_RS10790	COG0174	glutamine synthetase
JHW28_RS10795	COG1335	isochorismatase
JHW28_RS10805	COG0583	DNA-binding transcription factor activity
JHW28_RS10860	COG3193	protein, possibly involved in utilization of glycolate and propanediol
JHW28_RS10865	COG0247	lactate metabolic process
JHW28_RS10870	COG0277	FAD linked oxidase domain protein
JHW28_RS10875	COG0277	FAD linked oxidase domain protein
JHW28_RS10880	COG2186	Transcriptional regulator
JHW28_RS10910	COG1063	alcohol dehydrogenase
JHW28_RS10930	COG0709	Synthesizes selenophosphate from selenide and ATP
JHW28_RS10935	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JHW28_RS10940	COG0701	Predicted permease
JHW28_RS10945	COG1414	Transcriptional regulator
JHW28_RS10950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS10955	COG0765	amino acid transport
JHW28_RS10960	COG1126	abc transporter atp-binding protein
JHW28_RS10965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS10975	COG0625	glutathione transferase activity
JHW28_RS10980	COG0384	phenazine biosynthesis protein PhzF
JHW28_RS10995	COG0248	Ppx GppA phosphatase
JHW28_RS11000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JHW28_RS11020	COG0019	diaminopimelate decarboxylase activity
JHW28_RS11035	COG0071	Belongs to the small heat shock protein (HSP20) family
JHW28_RS11040	COG0113	porphobilinogen synthase activity
JHW28_RS11070	COG4172	Belongs to the ABC transporter superfamily
JHW28_RS11075	COG4239	(ABC) transporter, permease
JHW28_RS11080	COG4174	ABC transporter (Permease)
JHW28_RS11085	COG4166	transmembrane transport
JHW28_RS11120	COG4650	regulator
JHW28_RS11135	COG1690	Belongs to the RtcB family
JHW28_RS11145	COG3541	Predicted nucleotidyltransferase
JHW28_RS11150	COG0430	RNA-3'-phosphate cyclase activity
JHW28_RS11175	COG0583	DNA-binding transcription factor activity
JHW28_RS11200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JHW28_RS11205	COG0583	DNA-binding transcription factor activity
JHW28_RS11210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JHW28_RS11220	COG3180	Ammonia monooxygenase
JHW28_RS11225	COG0583	DNA-binding transcription factor activity
JHW28_RS11230	COG0517	IMP dehydrogenase activity
JHW28_RS11250	COG1177	transmembrane transport
JHW28_RS11255	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW28_RS11260	COG3842	ATPase activity
JHW28_RS11265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHW28_RS11270	COG0174	glutamine synthetase
JHW28_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS11280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS11285	COG1917	Cupin 2, conserved barrel domain protein
JHW28_RS11285	COG1396	sequence-specific DNA binding
JHW28_RS11290	COG0210	DNA helicase
JHW28_RS11340	COG1595	DNA-templated transcription, initiation
JHW28_RS11345	COG3712	iron ion homeostasis
JHW28_RS11350	COG4772	TonB-dependent receptor
JHW28_RS11355	COG1944	ATP diphosphatase activity
JHW28_RS11415	COG2223	nitrite transmembrane transporter activity
JHW28_RS11435	COG0697	spore germination
JHW28_RS11440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW28_RS11450	COG0659	secondary active sulfate transmembrane transporter activity
JHW28_RS11460	COG1999	signal sequence binding
JHW28_RS11475	COG0583	DNA-binding transcription factor activity
JHW28_RS11480	COG3048	D-serine ammonia-lyase activity
JHW28_RS11485	COG2610	gluconate transmembrane transporter activity
JHW28_RS11490	COG0251	oxidation-reduction process
JHW28_RS11500	COG0688	phosphatidylethanolamine metabolic process
JHW28_RS11515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHW28_RS11520	COG0346	lactoylglutathione lyase activity
JHW28_RS11530	COG0826	peptidase U32
JHW28_RS11545	COG2207	Transcriptional regulator
JHW28_RS11600	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHW28_RS11610	COG1611	Belongs to the LOG family
JHW28_RS11625	COG2204	response regulator
JHW28_RS11630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JHW28_RS11640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHW28_RS11660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS11665	COG0174	glutamine synthetase
JHW28_RS11680	COG1335	isochorismatase
JHW28_RS11685	COG3224	Antibiotic biosynthesis monooxygenase
JHW28_RS11690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
JHW28_RS11705	COG0417	DNA replication proofreading
JHW28_RS11715	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JHW28_RS11720	COG0477	Major facilitator Superfamily
JHW28_RS11740	COG4319	ketosteroid isomerase
JHW28_RS11745	COG4335	DNA alkylation repair
JHW28_RS11755	COG0583	DNA-binding transcription factor activity
JHW28_RS11760	COG2828	Protein conserved in bacteria
JHW28_RS11765	COG1301	dicarboxylic acid transport
JHW28_RS11770	COG2851	Citrate transporter
JHW28_RS11785	COG1704	LemA family
JHW28_RS11790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHW28_RS11810	COG1230	cation diffusion facilitator family transporter
JHW28_RS11815	COG2267	carboxylic ester hydrolase activity
JHW28_RS11825	COG2124	cytochrome p450
JHW28_RS11845	COG2308	Evidence 4 Homologs of previously reported genes of
JHW28_RS11855	COG1305	Transglutaminase-like
JHW28_RS11860	COG3023	N-Acetylmuramoyl-L-alanine amidase
JHW28_RS11865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHW28_RS11870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW28_RS11880	COG0022	dehydrogenase e1 component
JHW28_RS11885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JHW28_RS11890	COG1522	sequence-specific DNA binding
JHW28_RS11900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHW28_RS11930	COG1309	transcriptional regulator
JHW28_RS11940	COG0493	'glutamate synthase
JHW28_RS11950	COG1953	Uracil, thiamine, allantoin
JHW28_RS11960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS11965	COG4175	Glycine betaine
JHW28_RS11975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW28_RS11985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS12005	COG1595	DNA-templated transcription, initiation
JHW28_RS12015	COG1401	restriction endodeoxyribonuclease activity
JHW28_RS12060	COG2391	methyltransferase activity
JHW28_RS12125	COG0745	RESPONSE REGULATOR receiver
JHW28_RS12140	COG3383	formate dehydrogenase (NAD+) activity
JHW28_RS12145	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHW28_RS12150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS12185	COG3718	enzyme involved in inositol metabolism
JHW28_RS12200	COG3962	Belongs to the TPP enzyme family
JHW28_RS12205	COG0673	inositol 2-dehydrogenase activity
JHW28_RS12210	COG1082	Xylose isomerase domain protein TIM barrel
JHW28_RS12215	COG0673	inositol 2-dehydrogenase activity
JHW28_RS12230	COG1129	ABC transporter
JHW28_RS12235	COG4211	Belongs to the binding-protein-dependent transport system permease family
JHW28_RS12285	COG4774	siderophore transport
JHW28_RS12300	COG1320	monovalent cation:proton antiporter activity
JHW28_RS12305	COG2212	antiporter activity
JHW28_RS12315	COG0651	ATP synthesis coupled electron transport
JHW28_RS12320	COG1006	Multisubunit Na H antiporter MnhC subunit
JHW28_RS12325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JHW28_RS12325	COG2111	Na H antiporter
JHW28_RS12395	COG0673	inositol 2-dehydrogenase activity
JHW28_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS12415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW28_RS12420	COG1335	isochorismatase
JHW28_RS12435	COG3383	formate dehydrogenase (NAD+) activity
JHW28_RS12445	COG0814	amino acid
JHW28_RS12475	COG0589	response to stress
JHW28_RS12485	COG0745	RESPONSE REGULATOR receiver
JHW28_RS12490	COG2205	protein histidine kinase activity
JHW28_RS12505	COG3791	Glutathione-dependent formaldehyde-activating
JHW28_RS12520	COG0583	DNA-binding transcription factor activity
JHW28_RS12525	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
JHW28_RS12530	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS12535	COG2079	MmgE PrpD family protein
JHW28_RS12580	COG0583	DNA-binding transcription factor activity
JHW28_RS12600	COG0431	NADPH-dependent FMN reductase
JHW28_RS12665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHW28_RS12700	COG0583	DNA-binding transcription factor activity
JHW28_RS12710	COG1942	4-Oxalocrotonate Tautomerase
JHW28_RS12740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHW28_RS12755	COG0673	inositol 2-dehydrogenase activity
JHW28_RS12765	COG1609	Transcriptional regulator
JHW28_RS12810	COG0596	Alpha beta hydrolase
JHW28_RS12815	COG2384	SAM-dependent methyltransferase
JHW28_RS12830	COG0789	Transcriptional regulator
JHW28_RS12835	COG1090	epimerase
JHW28_RS12895	COG2080	2 iron, 2 sulfur cluster binding
JHW28_RS12900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JHW28_RS12905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW28_RS12910	COG1280	lysine exporter protein (LysE YggA)
JHW28_RS12915	COG2205	protein histidine kinase activity
JHW28_RS12945	COG1566	PFAM secretion protein HlyD family protein
JHW28_RS12955	COG2828	Protein conserved in bacteria
JHW28_RS12970	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JHW28_RS13010	COG2084	Dehydrogenase
JHW28_RS13015	COG3395	kinase activity
JHW28_RS13020	COG0235	Class ii aldolase
JHW28_RS13025	COG2610	gluconate transmembrane transporter activity
JHW28_RS13030	COG3622	Belongs to the hyi family
JHW28_RS13040	COG1349	DNA-binding transcription factor activity
JHW28_RS13100	COG4104	PAAR repeat-containing protein
JHW28_RS13120	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS13125	COG4221	oxidoreductase activity
JHW28_RS13130	COG0596	Alpha beta hydrolase
JHW28_RS13130	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHW28_RS13135	COG0604	alcohol dehydrogenase
JHW28_RS13135	COG3321	synthase
JHW28_RS13140	COG2200	EAL domain
JHW28_RS13140	COG2199	diguanylate cyclase activity
JHW28_RS13140	COG2202	Pas domain
JHW28_RS13145	COG0833	amino acid
JHW28_RS13150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS13155	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHW28_RS13170	COG0494	nUDIX hydrolase
JHW28_RS13180	COG3220	belongs to the UPF0276 family
JHW28_RS13190	COG2259	Doxx family
JHW28_RS13200	COG2205	protein histidine kinase activity
JHW28_RS13240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JHW28_RS13255	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHW28_RS13275	COG0754	glutathionylspermidine amidase activity
JHW28_RS13285	COG3766	membrane
JHW28_RS13305	COG1842	Phage shock protein A
JHW28_RS13340	COG0583	DNA-binding transcription factor activity
JHW28_RS13345	COG0300	oxidoreductase activity
JHW28_RS13370	COG4172	Belongs to the ABC transporter superfamily
JHW28_RS13375	COG4239	(ABC) transporter, permease
JHW28_RS13380	COG4174	ABC transporter (Permease)
JHW28_RS13385	COG4166	transmembrane transport
JHW28_RS13390	COG4166	transmembrane transport
JHW28_RS13395	COG1388	LysM domain
JHW28_RS13395	COG0741	lytic transglycosylase activity
JHW28_RS13400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHW28_RS13410	COG0328	RNA-DNA hybrid ribonuclease activity
JHW28_RS13425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHW28_RS13450	COG0431	NADPH-dependent FMN reductase
JHW28_RS13455	COG0640	Transcriptional regulator
JHW28_RS13470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JHW28_RS13475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHW28_RS13485	COG3139	Protein of unknown function (DUF1315)
JHW28_RS13495	COG0308	aminopeptidase N
JHW28_RS13500	COG0659	secondary active sulfate transmembrane transporter activity
JHW28_RS13520	COG2706	6-phosphogluconolactonase activity
JHW28_RS13550	COG0420	3'-5' exonuclease activity
JHW28_RS13565	COG0583	DNA-binding transcription factor activity
JHW28_RS13610	COG0714	Associated with various cellular activities
JHW28_RS13615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS13620	COG0477	Major facilitator Superfamily
JHW28_RS13625	COG0579	oxidoreductase
JHW28_RS13630	COG2186	Transcriptional regulator
JHW28_RS13660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW28_RS13815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHW28_RS13825	COG1247	-acetyltransferase
JHW28_RS13830	COG1794	racemase activity, acting on amino acids and derivatives
JHW28_RS13860	COG3278	Belongs to the heme-copper respiratory oxidase family
JHW28_RS13865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW28_RS13900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW28_RS13905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW28_RS13910	COG1538	Outer membrane efflux protein
JHW28_RS13920	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS13935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW28_RS13940	COG0348	domain, Protein
JHW28_RS13950	COG1285	pathogenesis
JHW28_RS13970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHW28_RS13980	COG3568	Endonuclease Exonuclease Phosphatase
JHW28_RS14005	COG1640	4-alpha-glucanotransferase
JHW28_RS14010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHW28_RS14015	COG0297	glycogen (starch) synthase activity
JHW28_RS14020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW28_RS14030	COG1238	metal cluster binding
JHW28_RS14070	COG0667	Aldo Keto reductase
JHW28_RS14075	COG0583	DNA-binding transcription factor activity
JHW28_RS14090	COG2366	antibiotic biosynthetic process
JHW28_RS14155	COG0583	DNA-binding transcription factor activity
JHW28_RS14165	COG1017	nitric oxide dioxygenase activity
JHW28_RS14165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW28_RS14170	COG0583	DNA-binding transcription factor activity
JHW28_RS14175	COG2066	Belongs to the glutaminase family
JHW28_RS14185	COG2233	PERMEase
JHW28_RS14195	COG0010	Belongs to the arginase family
JHW28_RS14210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHW28_RS14245	COG2194	sulfuric ester hydrolase activity
JHW28_RS14255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JHW28_RS14260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHW28_RS14265	COG0561	phosphatase activity
JHW28_RS14270	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHW28_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS14275	COG2030	dehydratase
JHW28_RS14290	COG3162	membrane
JHW28_RS14295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW28_RS14300	COG2151	metal-sulfur cluster biosynthetic enzyme
JHW28_RS14305	COG3396	Phenylacetate-CoA oxygenase
JHW28_RS14310	COG3460	Phenylacetate-CoA oxygenase
JHW28_RS14315	COG3396	Phenylacetate-CoA oxygenase
JHW28_RS14325	COG0183	Belongs to the thiolase family
JHW28_RS14330	COG2050	protein possibly involved in aromatic compounds catabolism
JHW28_RS14335	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW28_RS14340	COG1024	Enoyl-CoA hydratase
JHW28_RS14345	COG1024	Enoyl-CoA hydratase
JHW28_RS14355	COG3327	negative regulation of DNA-templated transcription, initiation
JHW28_RS14375	COG2204	response regulator
JHW28_RS14420	COG0840	transmembrane signaling receptor activity
JHW28_RS14425	COG1968	undecaprenyl-diphosphatase activity
JHW28_RS14445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHW28_RS14460	COG0488	(ABC) transporter
JHW28_RS14475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
JHW28_RS14485	COG2133	pyrroloquinoline quinone binding
JHW28_RS14495	COG0189	ligase activity
JHW28_RS14500	COG0598	Magnesium transport protein CorA
JHW28_RS14505	COG0024	Methionine aminopeptidase
JHW28_RS14520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JHW28_RS14525	COG4574	serine-type endopeptidase inhibitor activity
JHW28_RS14605	COG0726	polysaccharide deacetylase
JHW28_RS14675	COG1070	Carbohydrate kinase
JHW28_RS14695	COG1175	transmembrane transport
JHW28_RS14705	COG4774	siderophore transport
JHW28_RS14710	COG2207	Transcriptional regulator
JHW28_RS14715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHW28_RS14725	COG0183	Belongs to the thiolase family
JHW28_RS14730	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS14735	COG1024	Enoyl-CoA hydratase
JHW28_RS14740	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS14745	COG1024	Enoyl-CoA hydratase
JHW28_RS14760	COG2814	Major facilitator Superfamily
JHW28_RS14790	COG0765	amino acid transport
JHW28_RS14795	COG0165	Argininosuccinate lyase
JHW28_RS14820	COG2076	Multidrug Resistance protein
JHW28_RS14825	COG2076	Multidrug Resistance protein
JHW28_RS14830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JHW28_RS14835	COG0726	polysaccharide deacetylase
JHW28_RS14840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHW28_RS14840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS14845	COG0463	Glycosyl transferase, family 2
JHW28_RS14850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHW28_RS14865	COG1131	(ABC) transporter
JHW28_RS14895	COG0747	negative chemotaxis
JHW28_RS14915	COG0667	Aldo Keto reductase
JHW28_RS14920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW28_RS14925	COG4172	Belongs to the ABC transporter superfamily
JHW28_RS14940	COG0477	Major facilitator Superfamily
JHW28_RS14960	COG0405	Gamma-glutamyltransferase
JHW28_RS14990	COG0589	response to stress
JHW28_RS15080	COG0745	RESPONSE REGULATOR receiver
JHW28_RS15090	COG0251	oxidation-reduction process
JHW28_RS15110	COG2863	cytochrome
JHW28_RS15125	COG1231	oxidoreductase activity
JHW28_RS15130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS15135	COG0183	Belongs to the thiolase family
JHW28_RS15140	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS15150	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS15185	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW28_RS15185	COG1024	Enoyl-CoA hydratase
JHW28_RS15205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW28_RS15210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS15265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JHW28_RS15275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHW28_RS15280	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JHW28_RS15285	COG3540	Alkaline phosphatase
JHW28_RS15290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHW28_RS15310	COG0811	peptide transport
JHW28_RS15320	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JHW28_RS15350	COG2084	Dehydrogenase
JHW28_RS15375	COG1116	anion transmembrane transporter activity
JHW28_RS15380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS15385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS15390	COG0235	Class ii aldolase
JHW28_RS15395	COG0583	DNA-binding transcription factor activity
JHW28_RS15415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS15425	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS15450	COG4206	TonB-dependent receptor
JHW28_RS15465	COG2828	Protein conserved in bacteria
JHW28_RS15470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JHW28_RS15475	COG2851	Citrate transporter
JHW28_RS15505	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
JHW28_RS15530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JHW28_RS15535	COG0475	glutathione-regulated potassium exporter activity
JHW28_RS15565	COG1196	nuclear chromosome segregation
JHW28_RS15565	COG3264	Mechanosensitive ion channel
JHW28_RS15570	COG3706	GGDEF domain
JHW28_RS15575	COG0583	DNA-binding transcription factor activity
JHW28_RS15580	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS15585	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS15590	COG2323	membrane
JHW28_RS15600	COG1546	Belongs to the CinA family
JHW28_RS15600	COG1058	Belongs to the CinA family
JHW28_RS15665	COG0277	FAD linked oxidase domain protein
JHW28_RS15665	COG0247	lactate metabolic process
JHW28_RS15670	COG0583	DNA-binding transcription factor activity
JHW28_RS15685	COG4104	PAAR repeat-containing protein
JHW28_RS15705	COG2433	Pfam Transposase IS66
JHW28_RS15715	COG2175	clavaminate synthase activity
JHW28_RS15725	COG0583	DNA-binding transcription factor activity
JHW28_RS15755	COG2146	nitrite reductase [NAD(P)H] activity
JHW28_RS15755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW28_RS15760	COG2146	nitrite reductase [NAD(P)H] activity
JHW28_RS15760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW28_RS15765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHW28_RS15775	COG1120	ATPase activity
JHW28_RS15780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW28_RS15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW28_RS15790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHW28_RS15795	COG4264	IucA IucC family
JHW28_RS15805	COG4264	IucA IucC family
JHW28_RS15810	COG2814	Major facilitator Superfamily
JHW28_RS15815	COG0019	diaminopimelate decarboxylase activity
JHW28_RS15820	COG4264	IucA IucC family
JHW28_RS15825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW28_RS15830	COG4774	siderophore transport
JHW28_RS15835	COG3712	iron ion homeostasis
JHW28_RS15840	COG1595	DNA-templated transcription, initiation
JHW28_RS15860	COG0174	glutamine synthetase
JHW28_RS15875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS15880	COG2200	EAL domain
JHW28_RS15905	COG2205	protein histidine kinase activity
JHW28_RS15905	COG0784	Response regulator, receiver
JHW28_RS15935	COG1522	sequence-specific DNA binding
JHW28_RS15945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW28_RS15955	COG0473	3-isopropylmalate dehydrogenase activity
JHW28_RS15990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW28_RS15995	COG0601	transmembrane transport
JHW28_RS16000	COG0747	negative chemotaxis
JHW28_RS16005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS16045	COG0589	response to stress
JHW28_RS16050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS16055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS16060	COG1116	anion transmembrane transporter activity
JHW28_RS16075	COG1917	Cupin 2, conserved barrel domain protein
JHW28_RS16075	COG4977	sequence-specific DNA binding
JHW28_RS16080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS16090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS16095	COG1116	anion transmembrane transporter activity
JHW28_RS16120	COG0656	L-ascorbic acid biosynthetic process
JHW28_RS16125	COG0784	Response regulator, receiver
JHW28_RS16125	COG2205	protein histidine kinase activity
JHW28_RS16130	COG5001	Diguanylate cyclase
JHW28_RS16130	COG3300	MHYT domain
JHW28_RS16140	COG2197	response regulator
JHW28_RS16160	COG0513	Belongs to the DEAD box helicase family
JHW28_RS16180	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JHW28_RS16185	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JHW28_RS16230	COG1113	amino acid transport
JHW28_RS16250	COG0531	amino acid
JHW28_RS16275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHW28_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS16300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS16315	COG0210	DNA helicase
JHW28_RS16330	COG3321	synthase
JHW28_RS16330	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS16330	COG0604	alcohol dehydrogenase
JHW28_RS16385	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS16400	COG3469	chitinase activity
JHW28_RS16405	COG3397	chitin binding
JHW28_RS16410	COG0583	DNA-binding transcription factor activity
JHW28_RS16430	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS16450	COG2072	flavoprotein involved in K transport
JHW28_RS16455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS16465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS16480	COG1566	PFAM secretion protein HlyD family protein
JHW28_RS16505	COG2205	protein histidine kinase activity
JHW28_RS16505	COG0784	Response regulator, receiver
JHW28_RS16505	COG2198	Histidine kinase
JHW28_RS16515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHW28_RS16520	COG0784	Response regulator, receiver
JHW28_RS16520	COG2205	protein histidine kinase activity
JHW28_RS16520	COG2198	Histidine kinase
JHW28_RS16540	COG0672	)-iron permease
JHW28_RS16545	COG2822	iron ion transport
JHW28_RS16565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW28_RS16580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS16595	COG2816	NAD+ diphosphatase activity
JHW28_RS16600	COG1024	Enoyl-CoA hydratase
JHW28_RS16615	COG1335	isochorismatase
JHW28_RS16620	COG2205	protein histidine kinase activity
JHW28_RS16625	COG0745	RESPONSE REGULATOR receiver
JHW28_RS16630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS16665	COG1609	Transcriptional regulator
JHW28_RS16675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW28_RS16740	COG2814	Major facilitator Superfamily
JHW28_RS16745	COG1063	alcohol dehydrogenase
JHW28_RS16785	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS16790	COG3384	dioxygenase
JHW28_RS16800	COG2271	Major facilitator Superfamily
JHW28_RS16805	COG3971	2-oxopent-4-enoate hydratase activity
JHW28_RS16815	COG1929	Belongs to the glycerate kinase type-1 family
JHW28_RS16820	COG3835	regulator
JHW28_RS16825	COG2271	Major facilitator Superfamily
JHW28_RS16830	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS16840	COG0583	DNA-binding transcription factor activity
JHW28_RS16845	COG0667	Aldo Keto reductase
JHW28_RS16855	COG1846	Transcriptional regulator
JHW28_RS16865	COG0697	spore germination
JHW28_RS16870	COG0583	DNA-binding transcription factor activity
JHW28_RS16875	COG2200	EAL domain
JHW28_RS16940	COG3258	Cytochrome c
JHW28_RS16945	COG2863	cytochrome
JHW28_RS16970	COG3145	DNA-N1-methyladenine dioxygenase activity
JHW28_RS16975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHW28_RS16975	COG2169	Transcriptional regulator
JHW28_RS16985	COG0604	alcohol dehydrogenase
JHW28_RS17005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JHW28_RS17015	COG0488	(ABC) transporter
JHW28_RS17025	COG0393	Putative heavy-metal-binding
JHW28_RS17145	COG3179	chitinase
JHW28_RS17165	COG0583	DNA-binding transcription factor activity
JHW28_RS17170	COG0583	DNA-binding transcription factor activity
JHW28_RS17175	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHW28_RS17180	COG0300	oxidoreductase activity
JHW28_RS17190	COG0583	DNA-binding transcription factor activity
JHW28_RS17195	COG1309	transcriptional regulator
JHW28_RS17220	COG0475	glutathione-regulated potassium exporter activity
JHW28_RS17235	COG0515	serine threonine protein kinase
JHW28_RS17255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS17260	COG0789	Transcriptional regulator
JHW28_RS17275	COG3604	Transcriptional regulator
JHW28_RS17280	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JHW28_RS17305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHW28_RS17310	COG0315	cyclic pyranopterin monophosphate synthase activity
JHW28_RS17345	COG3712	iron ion homeostasis
JHW28_RS17350	COG1595	DNA-templated transcription, initiation
JHW28_RS17390	COG0583	DNA-binding transcription factor activity
JHW28_RS17395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS17405	COG0861	Integral membrane protein TerC family
JHW28_RS17415	COG0583	DNA-binding transcription factor activity
JHW28_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS17425	COG2271	Major facilitator Superfamily
JHW28_RS17430	COG3959	Transketolase, thiamine diphosphate binding domain
JHW28_RS17435	COG3958	Transketolase
JHW28_RS17490	COG0583	DNA-binding transcription factor activity
JHW28_RS17500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JHW28_RS17515	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS17525	COG0657	acetylesterase activity
JHW28_RS17530	COG2207	Transcriptional regulator
JHW28_RS17535	COG1064	alcohol dehydrogenase
JHW28_RS17555	COG1733	regulation of RNA biosynthetic process
JHW28_RS17585	COG1022	Amp-dependent synthetase and ligase
JHW28_RS17590	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS17595	COG1024	Enoyl-CoA hydratase
JHW28_RS17610	COG2814	Major facilitator Superfamily
JHW28_RS17625	COG0577	efflux transmembrane transporter activity
JHW28_RS17625	COG1136	(ABC) transporter
JHW28_RS17630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS17690	COG2197	response regulator
JHW28_RS17695	COG1538	Outer membrane efflux protein
JHW28_RS17725	COG3622	Belongs to the hyi family
JHW28_RS17740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JHW28_RS17750	COG1136	(ABC) transporter
JHW28_RS17755	COG0515	serine threonine protein kinase
JHW28_RS17755	COG2815	serine threonine protein kinase
JHW28_RS17890	COG4191	Histidine kinase
JHW28_RS17895	COG4566	intracellular signal transduction
JHW28_RS17900	COG4566	intracellular signal transduction
JHW28_RS17925	COG0583	DNA-binding transcription factor activity
JHW28_RS17935	COG1335	isochorismatase
JHW28_RS17940	COG1574	metal-dependent hydrolase with the TIM-barrel fold
JHW28_RS17960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JHW28_RS17995	COG1741	Belongs to the pirin family
JHW28_RS18020	COG1335	isochorismatase
JHW28_RS18040	COG2814	Major facilitator Superfamily
JHW28_RS18045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW28_RS18045	COG2010	Cytochrome c
JHW28_RS18050	COG2080	2 iron, 2 sulfur cluster binding
JHW28_RS18055	COG2010	Cytochrome c
JHW28_RS18055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW28_RS18060	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS18065	COG2205	protein histidine kinase activity
JHW28_RS18065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS18070	COG1301	dicarboxylic acid transport
JHW28_RS18080	COG2207	Transcriptional regulator
JHW28_RS18085	COG0300	oxidoreductase activity
JHW28_RS18090	COG0702	epimerase
JHW28_RS18095	COG0583	DNA-binding transcription factor activity
JHW28_RS18105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHW28_RS18110	COG1733	regulation of RNA biosynthetic process
JHW28_RS18115	COG0583	DNA-binding transcription factor activity
JHW28_RS18130	COG0583	DNA-binding transcription factor activity
JHW28_RS18160	COG2851	Citrate transporter
JHW28_RS18170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHW28_RS18175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JHW28_RS18185	COG1414	Transcriptional regulator
JHW28_RS18190	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHW28_RS18190	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS18210	COG0179	Fumarylacetoacetate (FAA) hydrolase
JHW28_RS18215	COG3971	2-oxopent-4-enoate hydratase activity
JHW28_RS18235	COG2721	sulfolactate sulfo-lyase activity
JHW28_RS18240	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS18245	COG0477	Major facilitator Superfamily
JHW28_RS18250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHW28_RS18285	COG0322	excinuclease ABC activity
JHW28_RS18290	COG2197	response regulator
JHW28_RS18310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHW28_RS18315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHW28_RS18320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHW28_RS18325	COG4166	transmembrane transport
JHW28_RS18330	COG4174	ABC transporter (Permease)
JHW28_RS18335	COG4239	(ABC) transporter, permease
JHW28_RS18340	COG4172	Belongs to the ABC transporter superfamily
JHW28_RS18350	COG2610	gluconate transmembrane transporter activity
JHW28_RS18355	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS18360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHW28_RS18370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHW28_RS18375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW28_RS18410	COG1607	acyl-coa hydrolase
JHW28_RS18415	COG0069	glutamate synthase activity
JHW28_RS18420	COG2026	Addiction module toxin, RelE StbE family
JHW28_RS18450	COG2199	diguanylate cyclase activity
JHW28_RS18450	COG2203	Gaf domain
JHW28_RS18460	COG1253	flavin adenine dinucleotide binding
JHW28_RS18495	COG0583	DNA-binding transcription factor activity
JHW28_RS18555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JHW28_RS18555	COG0316	Belongs to the HesB IscA family
JHW28_RS18590	COG0616	signal peptide processing
JHW28_RS18605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS18605	COG1024	Enoyl-CoA hydratase
JHW28_RS18635	COG3189	MarR family transcriptional regulator
JHW28_RS18640	COG2186	Transcriptional regulator
JHW28_RS18715	COG0784	Response regulator, receiver
JHW28_RS18715	COG4191	Histidine kinase
JHW28_RS18720	COG0587	DNA-directed DNA polymerase activity
JHW28_RS18735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHW28_RS18760	COG0673	inositol 2-dehydrogenase activity
JHW28_RS18795	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS18805	COG0303	'Molybdopterin
JHW28_RS18810	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHW28_RS18815	COG0746	molybdenum cofactor guanylyltransferase activity
JHW28_RS18820	COG0583	DNA-binding transcription factor activity
JHW28_RS18835	COG0315	cyclic pyranopterin monophosphate synthase activity
JHW28_RS18840	COG3781	membrane
JHW28_RS18845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHW28_RS18855	COG1271	oxidase subunit
JHW28_RS18860	COG1294	oxidase, subunit
JHW28_RS18880	COG0243	molybdopterin cofactor binding
JHW28_RS18885	COG0697	spore germination
JHW28_RS18890	COG1522	sequence-specific DNA binding
JHW28_RS18945	COG2989	Protein conserved in bacteria
JHW28_RS18960	COG5001	Diguanylate cyclase
JHW28_RS18960	COG3300	MHYT domain
JHW28_RS18970	COG1858	cytochrome C peroxidase
JHW28_RS18995	COG0579	oxidoreductase
JHW28_RS19040	COG2920	part of a sulfur-relay system
JHW28_RS19045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHW28_RS19050	COG0435	Glutathione S-transferase
JHW28_RS19055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHW28_RS19055	COG1648	precorrin-2 dehydrogenase activity
JHW28_RS19060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JHW28_RS19065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JHW28_RS19070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JHW28_RS19075	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JHW28_RS19080	COG1674	ftsk spoiiie
JHW28_RS19085	COG0492	ferredoxin-NADP+ reductase activity
JHW28_RS19090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JHW28_RS19095	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JHW28_RS19100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHW28_RS19105	COG0542	response to heat
JHW28_RS19110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JHW28_RS19115	COG1278	Cold shock
JHW28_RS19135	COG0482	sulfurtransferase activity
JHW28_RS19140	COG2915	High frequency lysogenization protein hflD homolog
JHW28_RS19150	COG2850	peptidyl-arginine hydroxylation
JHW28_RS19155	COG2153	protein acetylation
JHW28_RS19170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW28_RS19175	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW28_RS19180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW28_RS19180	COG0649	NAD binding
JHW28_RS19195	COG1034	ATP synthesis coupled electron transport
JHW28_RS19200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JHW28_RS19205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW28_RS19215	COG0713	ATP synthesis coupled electron transport
JHW28_RS19230	COG1007	ATP synthesis coupled electron transport
JHW28_RS19235	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
JHW28_RS19240	COG2944	sequence-specific DNA binding
JHW28_RS19255	COG0395	ABC-type sugar transport system, permease component
JHW28_RS19265	COG3842	ATPase activity
JHW28_RS19270	COG3842	ATPase activity
JHW28_RS19275	COG3284	Transcriptional regulator
JHW28_RS19280	COG0215	cysteine-tRNA ligase activity
JHW28_RS19285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHW28_RS19295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW28_RS19300	COG2814	Major facilitator Superfamily
JHW28_RS19305	COG1566	PFAM secretion protein HlyD family protein
JHW28_RS19315	COG1846	Transcriptional regulator
JHW28_RS19320	COG2911	Protein conserved in bacteria
JHW28_RS19325	COG0729	surface antigen
JHW28_RS19335	COG0708	Exodeoxyribonuclease III
JHW28_RS19345	COG2885	chlorophyll binding
JHW28_RS19360	COG0789	Transcriptional regulator
JHW28_RS19370	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS19375	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS19380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHW28_RS19395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHW28_RS19405	COG2866	Carboxypeptidase
JHW28_RS19415	COG2814	Major facilitator Superfamily
JHW28_RS19420	COG3038	cytochrome b561
JHW28_RS19475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHW28_RS19485	COG0217	transcriptional regulatory protein
JHW28_RS19490	COG0583	DNA-binding transcription factor activity
JHW28_RS19495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHW28_RS19500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW28_RS19505	COG3038	cytochrome b561
JHW28_RS19515	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHW28_RS19515	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS19540	COG2814	Major facilitator Superfamily
JHW28_RS19545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHW28_RS19550	COG0776	regulation of translation
JHW28_RS19555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHW28_RS19560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHW28_RS19565	COG0740	serine-type endopeptidase activity
JHW28_RS19570	COG0544	peptidyl-prolyl cis-trans isomerase activity
JHW28_RS19590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHW28_RS19595	COG1686	Belongs to the peptidase S11 family
JHW28_RS19610	COG1253	flavin adenine dinucleotide binding
JHW28_RS19620	COG0583	DNA-binding transcription factor activity
JHW28_RS19630	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JHW28_RS19640	COG3132	Protein of unknown function, DUF480
JHW28_RS19650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHW28_RS19670	COG0628	permease
JHW28_RS19675	COG0826	peptidase U32
JHW28_RS19685	COG2056	Na+-H+ antiporter family
JHW28_RS19690	COG0840	transmembrane signaling receptor activity
JHW28_RS19720	COG0720	synthase
JHW28_RS19730	COG0596	Alpha beta hydrolase
JHW28_RS19755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHW28_RS19760	COG0402	S-adenosylhomocysteine deaminase activity
JHW28_RS19765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHW28_RS19780	COG1725	Transcriptional regulator
JHW28_RS19785	COG2207	Transcriptional regulator
JHW28_RS19795	COG0583	DNA-binding transcription factor activity
JHW28_RS19805	COG1522	sequence-specific DNA binding
JHW28_RS19815	COG2223	nitrite transmembrane transporter activity
JHW28_RS19820	COG4772	TonB-dependent receptor
JHW28_RS19830	COG1595	DNA-templated transcription, initiation
JHW28_RS19840	COG3210	domain, Protein
JHW28_RS19875	COG2274	protein secretion by the type I secretion system
JHW28_RS19880	COG1538	Outer membrane efflux protein
JHW28_RS19885	COG2080	2 iron, 2 sulfur cluster binding
JHW28_RS19890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW28_RS19890	COG2010	Cytochrome c
JHW28_RS19895	COG2010	Cytochrome c
JHW28_RS19895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW28_RS19910	COG0840	transmembrane signaling receptor activity
JHW28_RS19915	COG4774	siderophore transport
JHW28_RS19920	COG0583	DNA-binding transcription factor activity
JHW28_RS19930	COG3591	Belongs to the peptidase S1B family
JHW28_RS19930	COG1864	DNA RNA non-specific endonuclease
JHW28_RS19950	COG4106	trans-aconitate 2-methyltransferase activity
JHW28_RS19970	COG5507	3-demethylubiquinone-9 3-methyltransferase
JHW28_RS19985	COG3135	benzoate transporter
JHW28_RS19990	COG2814	Major facilitator Superfamily
JHW28_RS20020	COG3485	protocatechuate 3,4-dioxygenase
JHW28_RS20025	COG4829	muconolactone delta-isomerase
JHW28_RS20030	COG4948	Mandelate Racemase Muconate Lactonizing
JHW28_RS20070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHW28_RS20115	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHW28_RS20155	COG0154	amidase activity
JHW28_RS20160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW28_RS20190	COG3012	SEC-C Motif Domain Protein
JHW28_RS20190	COG3318	Belongs to the UPF0149 family
JHW28_RS20195	COG0730	response to heat
JHW28_RS20220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW28_RS20230	COG1335	isochorismatase
JHW28_RS20235	COG1335	isochorismatase
JHW28_RS20245	COG0583	DNA-binding transcription factor activity
JHW28_RS20255	COG0656	L-ascorbic acid biosynthetic process
JHW28_RS20290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS20295	COG0577	efflux transmembrane transporter activity
JHW28_RS20295	COG1136	(ABC) transporter
JHW28_RS20300	COG1538	Outer membrane efflux protein
JHW28_RS20355	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
JHW28_RS20375	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS20380	COG3387	PFAM Glycoside hydrolase 15-related
JHW28_RS20410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW28_RS20415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHW28_RS20485	COG0840	transmembrane signaling receptor activity
JHW28_RS20520	COG1132	(ABC) transporter
JHW28_RS20555	COG3338	carbonate dehydratase activity
JHW28_RS20585	COG3121	Chaperone
JHW28_RS20590	COG3188	usher protein
JHW28_RS20605	COG2197	response regulator
JHW28_RS20610	COG5001	Diguanylate cyclase
JHW28_RS20630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JHW28_RS20680	COG0477	Major facilitator Superfamily
JHW28_RS20685	COG0583	DNA-binding transcription factor activity
JHW28_RS20690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW28_RS20695	COG0235	Class ii aldolase
JHW28_RS20700	COG0477	Major facilitator Superfamily
JHW28_RS20705	COG0583	DNA-binding transcription factor activity
JHW28_RS20710	COG0768	penicillin binding
JHW28_RS20720	COG1063	alcohol dehydrogenase
JHW28_RS20750	COG5006	permease, DMT superfamily
JHW28_RS20760	COG1309	transcriptional regulator
JHW28_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS20790	COG0431	NADPH-dependent FMN reductase
JHW28_RS20795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS20805	COG3829	transcription factor binding
JHW28_RS20850	COG1121	(ABC) transporter
JHW28_RS20855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHW28_RS20865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW28_RS20880	COG0642	Histidine kinase
JHW28_RS20890	COG4232	protein-disulfide reductase activity
JHW28_RS20895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHW28_RS20920	COG2267	carboxylic ester hydrolase activity
JHW28_RS20945	COG1309	transcriptional regulator
JHW28_RS20960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHW28_RS20965	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS20970	COG1024	Enoyl-CoA hydratase
JHW28_RS20985	COG3123	guanosine phosphorylase activity
JHW28_RS20990	COG0633	Ferredoxin
JHW28_RS20990	COG3217	Mosc domain protein beta barrel domain protein
JHW28_RS21005	COG3851	Histidine kinase
JHW28_RS21010	COG2197	response regulator
JHW28_RS21015	COG1597	lipid kinase activity
JHW28_RS21025	COG0303	'Molybdopterin
JHW28_RS21030	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHW28_RS21035	COG0746	molybdenum cofactor guanylyltransferase activity
JHW28_RS21045	COG0564	pseudouridine synthase activity
JHW28_RS21070	COG0004	ammonium transporteR
JHW28_RS21090	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JHW28_RS21110	COG2197	response regulator
JHW28_RS21140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS21150	COG1538	Outer membrane efflux protein
JHW28_RS21205	COG3188	usher protein
JHW28_RS21220	COG0288	reversible hydration of carbon dioxide
JHW28_RS21225	COG2197	response regulator
JHW28_RS21240	COG0784	Response regulator, receiver
JHW28_RS21240	COG2205	protein histidine kinase activity
JHW28_RS21310	COG2197	response regulator
JHW28_RS21315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS21315	COG2205	protein histidine kinase activity
JHW28_RS21320	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JHW28_RS21325	COG1956	GAF domain-containing protein
JHW28_RS21335	COG2205	protein histidine kinase activity
JHW28_RS21335	COG5002	protein histidine kinase activity
JHW28_RS21335	COG0784	Response regulator, receiver
JHW28_RS21340	COG1846	Transcriptional regulator
JHW28_RS21345	COG0386	Belongs to the glutathione peroxidase family
JHW28_RS21350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW28_RS21355	COG0436	Aminotransferase
JHW28_RS21360	COG0501	Belongs to the peptidase M48B family
JHW28_RS21365	COG0500	methyltransferase
JHW28_RS21370	COG3384	dioxygenase
JHW28_RS21385	COG1024	Enoyl-CoA hydratase
JHW28_RS21395	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JHW28_RS21400	COG3214	Protein conserved in bacteria
JHW28_RS21410	COG0583	DNA-binding transcription factor activity
JHW28_RS21420	COG0583	DNA-binding transcription factor activity
JHW28_RS21425	COG1846	Transcriptional regulator
JHW28_RS21430	COG1764	response to oxidative stress
JHW28_RS21440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHW28_RS21455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW28_RS21475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHW28_RS21505	COG1376	ErfK ybiS ycfS ynhG family protein
JHW28_RS21520	COG4181	ATPase activity
JHW28_RS21525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JHW28_RS21530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW28_RS21545	COG2197	response regulator
JHW28_RS21555	COG2259	Doxx family
JHW28_RS21560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHW28_RS21565	COG0084	hydrolase, TatD family'
JHW28_RS21600	COG0745	RESPONSE REGULATOR receiver
JHW28_RS21605	COG2205	protein histidine kinase activity
JHW28_RS21610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JHW28_RS21620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JHW28_RS21655	COG4221	oxidoreductase activity
JHW28_RS21675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHW28_RS21690	COG0297	glycogen (starch) synthase activity
JHW28_RS21695	COG1216	Glycosyl transferase, family 2
JHW28_RS21715	COG0776	regulation of translation
JHW28_RS21730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHW28_RS21735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JHW28_RS21740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHW28_RS21750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JHW28_RS21760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JHW28_RS21765	COG0402	S-adenosylhomocysteine deaminase activity
JHW28_RS21770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW28_RS21775	COG0546	phosphoglycolate phosphatase activity
JHW28_RS21780	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS21795	COG5002	protein histidine kinase activity
JHW28_RS21795	COG5001	Diguanylate cyclase
JHW28_RS21810	COG1054	Belongs to the UPF0176 family
JHW28_RS21815	COG0271	Belongs to the BolA IbaG family
JHW28_RS21825	COG0114	fumarate hydratase activity
JHW28_RS21830	COG0697	spore germination
JHW28_RS21835	COG0183	Belongs to the thiolase family
JHW28_RS21840	COG2326	polyphosphate kinase activity
JHW28_RS21845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS21845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHW28_RS21850	COG0367	asparagine synthase
JHW28_RS21855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHW28_RS21855	COG0189	ligase activity
JHW28_RS21860	COG1363	Peptidase, m42
JHW28_RS21865	COG3089	Belongs to the UPF0270 family
JHW28_RS21870	COG1742	UPF0060 membrane protein
JHW28_RS21885	COG1368	sulfuric ester hydrolase activity
JHW28_RS21905	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS21915	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
JHW28_RS21920	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JHW28_RS21925	COG0235	Class ii aldolase
JHW28_RS21935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHW28_RS21940	COG1073	alpha beta
JHW28_RS21965	COG2840	Smr protein MutS2
JHW28_RS21970	COG0302	gtp cyclohydrolase
JHW28_RS21980	COG0625	glutathione transferase activity
JHW28_RS21985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW28_RS21995	COG2252	PERMEase
JHW28_RS22020	COG4266	Belongs to the allantoicase family
JHW28_RS22025	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
JHW28_RS22035	COG2233	PERMEase
JHW28_RS22060	COG1560	Kdo2-lipid A biosynthetic process
JHW28_RS22065	COG0850	regulation of cytokinetic process
JHW28_RS22070	COG2894	cell division
JHW28_RS22075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JHW28_RS22080	COG0564	pseudouridine synthase activity
JHW28_RS22090	COG1362	aminopeptidase activity
JHW28_RS22100	COG0668	transmembrane transport
JHW28_RS22105	COG1473	amidohydrolase
JHW28_RS22135	COG3842	ATPase activity
JHW28_RS22145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JHW28_RS22145	COG0604	alcohol dehydrogenase
JHW28_RS22145	COG4221	oxidoreductase activity
JHW28_RS22145	COG3321	synthase
JHW28_RS22155	COG2200	EAL domain
JHW28_RS22180	COG0545	Peptidyl-prolyl cis-trans isomerase
JHW28_RS22185	COG2010	Cytochrome c
JHW28_RS22215	COG2974	May be involved in recombination
JHW28_RS22220	COG0385	Bile acid
JHW28_RS22225	COG2076	Multidrug Resistance protein
JHW28_RS22255	COG2205	protein histidine kinase activity
JHW28_RS22255	COG2202	Pas domain
JHW28_RS22300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JHW28_RS22305	COG0406	alpha-ribazole phosphatase activity
JHW28_RS22310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JHW28_RS22320	COG1492	cobalamin metabolic process
JHW28_RS22335	COG0778	Nitroreductase
JHW28_RS22340	COG1797	cobyrinic acid a,c-diamide synthase activity
JHW28_RS22365	COG0791	NLP P60 protein
JHW28_RS22370	COG0791	NLP P60 protein
JHW28_RS22375	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHW28_RS22380	COG0628	permease
JHW28_RS22390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JHW28_RS22395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JHW28_RS22410	COG3122	Protein conserved in bacteria
JHW28_RS22415	COG3956	TIGRFAM MazG family protein
JHW28_RS22420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHW28_RS22425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHW28_RS22445	COG0784	Response regulator, receiver
JHW28_RS22445	COG2205	protein histidine kinase activity
JHW28_RS22445	COG5002	protein histidine kinase activity
JHW28_RS22450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW28_RS22470	COG1393	Belongs to the ArsC family
JHW28_RS22485	COG2818	Glycosylase
JHW28_RS22490	COG0037	tRNA processing
JHW28_RS22500	COG3091	SprT-like family
JHW28_RS22505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JHW28_RS22545	COG2205	protein histidine kinase activity
JHW28_RS22550	COG0745	RESPONSE REGULATOR receiver
JHW28_RS22560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHW28_RS22560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHW28_RS22575	COG1558	bacterial-type flagellum-dependent cell motility
JHW28_RS22580	COG1815	bacterial-type flagellum-dependent cell motility
JHW28_RS22585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHW28_RS22590	COG0835	chemotaxis
JHW28_RS22590	COG0784	Response regulator, receiver
JHW28_RS22610	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
JHW28_RS22615	COG0477	Major facilitator Superfamily
JHW28_RS22625	COG2205	protein histidine kinase activity
JHW28_RS22655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS22685	COG2239	Acts as a magnesium transporter
JHW28_RS22705	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JHW28_RS22710	COG0527	aspartate kinase activity
JHW28_RS22715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHW28_RS22720	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHW28_RS22725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JHW28_RS22730	COG2988	succinylglutamate desuccinylase activity
JHW28_RS22740	COG3724	N-succinylarginine dihydrolase activity
JHW28_RS22745	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS22760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHW28_RS22790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS22795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHW28_RS22805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHW28_RS22840	COG0563	adenylate kinase activity
JHW28_RS22855	COG3706	GGDEF domain
JHW28_RS22875	COG0504	CTP synthase activity
JHW28_RS22880	COG2329	Antibiotic biosynthesis monooxygenase
JHW28_RS22890	COG0584	glycerophosphoryl diester phosphodiesterase
JHW28_RS22920	COG0306	phosphate transporter
JHW28_RS22930	COG3008	intermembrane lipid transfer
JHW28_RS22935	COG2995	paraquat-inducible protein a
JHW28_RS22940	COG2995	paraquat-inducible protein a
JHW28_RS22955	COG0583	DNA-binding transcription factor activity
JHW28_RS22960	COG4941	Belongs to the sigma-70 factor family
JHW28_RS22970	COG3795	YCII-related domain
JHW28_RS23015	COG0436	Aminotransferase
JHW28_RS23025	COG3265	gluconokinase activity
JHW28_RS23030	COG1609	Transcriptional regulator
JHW28_RS23035	COG0583	DNA-binding transcription factor activity
JHW28_RS23045	COG0625	glutathione transferase activity
JHW28_RS23050	COG2271	Major facilitator Superfamily
JHW28_RS23060	COG0583	DNA-binding transcription factor activity
JHW28_RS23070	COG2986	histidine ammonia-lyase
JHW28_RS23080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS23095	COG3712	iron ion homeostasis
JHW28_RS23100	COG1595	DNA-templated transcription, initiation
JHW28_RS23125	COG0242	peptide deformylase activity
JHW28_RS23130	COG1295	ribonuclease BN
JHW28_RS23190	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS23195	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS23200	COG2267	carboxylic ester hydrolase activity
JHW28_RS23205	COG2030	dehydratase
JHW28_RS23230	COG3530	Putative quorum-sensing-regulated virulence factor
JHW28_RS23235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHW28_RS23240	COG0800	Aldolase
JHW28_RS23255	COG1737	Transcriptional regulator
JHW28_RS23260	COG0676	glucose-6-phosphate 1-epimerase activity
JHW28_RS23270	COG3842	ATPase activity
JHW28_RS23275	COG0395	ABC-type sugar transport system, permease component
JHW28_RS23280	COG1175	transmembrane transport
JHW28_RS23285	COG1653	transport
JHW28_RS23320	COG1803	Methylglyoxal synthase
JHW28_RS23330	COG3712	iron ion homeostasis
JHW28_RS23335	COG4771	TonB-dependent receptor
JHW28_RS23345	COG2832	Protein of unknown function (DUF454)
JHW28_RS23350	COG0840	transmembrane signaling receptor activity
JHW28_RS23355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JHW28_RS23375	COG2235	arginine
JHW28_RS23380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHW28_RS23400	COG0509	glycine decarboxylation via glycine cleavage system
JHW28_RS23405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHW28_RS23405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHW28_RS23410	COG1760	l-serine dehydratase
JHW28_RS23420	COG1278	Cold shock
JHW28_RS23430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JHW28_RS23435	COG4964	Belongs to the GSP D family
JHW28_RS23525	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW28_RS23530	COG1129	ABC transporter
JHW28_RS23535	COG1879	ABC-type sugar transport system periplasmic component
JHW28_RS23545	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS23570	COG2894	cell division
JHW28_RS23590	COG0305	Participates in initiation and elongation during chromosome replication
JHW28_RS23600	COG3081	Nucleoid-associated protein
JHW28_RS23655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHW28_RS23660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHW28_RS23705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHW28_RS23785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHW28_RS23790	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
JHW28_RS23805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JHW28_RS23810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHW28_RS23820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHW28_RS23825	COG0142	geranyltranstransferase activity
JHW28_RS24000	COG3609	addiction module antidote protein, CC2985 family
JHW28_RS24015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JHW28_RS24025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHW28_RS24030	COG0602	queuosine metabolic process
JHW28_RS24035	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JHW28_RS24040	COG2885	chlorophyll binding
JHW28_RS24045	COG0823	Involved in the tonB-independent uptake of proteins
JHW28_RS24065	COG0824	Thioesterase
JHW28_RS24070	COG2255	four-way junction helicase activity
JHW28_RS24075	COG0632	four-way junction helicase activity
JHW28_RS24080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JHW28_RS24085	COG0217	transcriptional regulatory protein
JHW28_RS24090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHW28_RS24100	COG0783	Belongs to the Dps family
JHW28_RS24110	COG2900	Belongs to the SlyX family
JHW28_RS24125	COG0668	transmembrane transport
JHW28_RS24130	COG1666	GTP binding
JHW28_RS24140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS24140	COG4191	Histidine kinase
JHW28_RS24145	COG2096	Adenosyltransferase
JHW28_RS24150	COG0352	thiamine-phosphate diphosphorylase activity
JHW28_RS24160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JHW28_RS24165	COG0653	protein targeting
JHW28_RS24175	COG0433	COG0433 Predicted ATPase
JHW28_RS24185	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS24185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHW28_RS24215	COG2925	Exonuclease
JHW28_RS24240	COG0714	Associated with various cellular activities
JHW28_RS24260	COG0469	pyruvate kinase activity
JHW28_RS24265	COG1024	Enoyl-CoA hydratase
JHW28_RS24275	COG3706	GGDEF domain
JHW28_RS24285	COG4191	Histidine kinase
JHW28_RS24295	COG0477	Major facilitator Superfamily
JHW28_RS24325	COG2207	Transcriptional regulator
JHW28_RS24330	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS24340	COG0583	DNA-binding transcription factor activity
JHW28_RS24345	COG2910	NAD(P)H-binding
JHW28_RS24355	COG0583	DNA-binding transcription factor activity
JHW28_RS24390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHW28_RS24395	COG0583	DNA-binding transcription factor activity
JHW28_RS24410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JHW28_RS24440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS24445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW28_RS24455	COG3642	lipopolysaccharide core region biosynthetic process
JHW28_RS24465	COG0642	Histidine kinase
JHW28_RS24480	COG0459	protein refolding
JHW28_RS24485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHW28_RS24490	COG3030	protein affecting phage T7 exclusion by the F plasmid
JHW28_RS24500	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS24505	COG0489	protein tyrosine kinase activity
JHW28_RS24510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHW28_RS24510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHW28_RS24515	COG4657	Part of a membrane complex involved in electron transport
JHW28_RS24520	COG2878	Part of a membrane complex involved in electron transport
JHW28_RS24525	COG4658	electron transport chain
JHW28_RS24535	COG4660	Part of a membrane complex involved in electron transport
JHW28_RS24540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHW28_RS24550	COG2197	response regulator
JHW28_RS24555	COG0137	argininosuccinate synthase activity
JHW28_RS24565	COG0418	dihydroorotase activity
JHW28_RS24570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHW28_RS24575	COG0450	alkyl hydroperoxide reductase
JHW28_RS24590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JHW28_RS24595	COG3383	formate dehydrogenase (NAD+) activity
JHW28_RS24605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHW28_RS24610	COG3842	ATPase activity
JHW28_RS24620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHW28_RS24630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHW28_RS24650	COG0765	amino acid transport
JHW28_RS24655	COG0765	amino acid transport
JHW28_RS24660	COG1126	abc transporter atp-binding protein
JHW28_RS24690	COG2076	Multidrug Resistance protein
JHW28_RS24710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHW28_RS24725	COG4191	Histidine kinase
JHW28_RS24730	COG2204	response regulator
JHW28_RS24735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JHW28_RS24740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHW28_RS24745	COG0583	DNA-binding transcription factor activity
JHW28_RS24750	COG0456	acetyltransferase
JHW28_RS24755	COG1280	lysine exporter protein (LysE YggA)
JHW28_RS24765	COG0254	rRNA binding
JHW28_RS24775	COG0069	glutamate synthase activity
JHW28_RS24800	COG2246	polysaccharide biosynthetic process
JHW28_RS24815	COG1113	amino acid transport
JHW28_RS24825	COG1695	Transcriptional regulator
JHW28_RS24830	COG2375	cellular response to nickel ion
JHW28_RS24840	COG4628	conserved protein (DUF2132)
JHW28_RS24845	COG4206	TonB-dependent receptor
JHW28_RS24880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHW28_RS24895	COG2226	methyltransferase
JHW28_RS24900	COG0500	methyltransferase
JHW28_RS24905	COG0590	tRNA wobble adenosine to inosine editing
JHW28_RS24920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW28_RS24920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHW28_RS24925	COG4580	involved in the transport of maltose and maltodextrins
JHW28_RS24930	COG0366	Alpha amylase catalytic
JHW28_RS24935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW28_RS24935	COG1263	PTS System
JHW28_RS24940	COG2188	Transcriptional regulator
JHW28_RS24965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHW28_RS24965	COG0519	Catalyzes the synthesis of GMP from XMP
JHW28_RS24990	COG1570	exodeoxyribonuclease VII activity
JHW28_RS24995	COG0739	heme binding
JHW28_RS25000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHW28_RS25015	COG0436	Aminotransferase
JHW28_RS25020	COG1160	GTP binding
JHW28_RS25035	COG0124	histidyl-tRNA synthetase
JHW28_RS25040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHW28_RS25045	COG1426	Protein conserved in bacteria
JHW28_RS25055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JHW28_RS25060	COG0105	UTP biosynthetic process
JHW28_RS25070	COG0633	Ferredoxin
JHW28_RS25075	COG0443	Heat shock 70 kDa protein
JHW28_RS25080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHW28_RS25095	COG1104	cysteine desulfurase activity
JHW28_RS25105	COG1045	serine acetyltransferase
JHW28_RS25120	COG3134	Outer membrane lipoprotein
JHW28_RS25135	COG1862	Preprotein translocase
JHW28_RS25140	COG0343	queuine tRNA-ribosyltransferase activity
JHW28_RS25145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JHW28_RS25170	COG2853	Lipoprotein
JHW28_RS25210	COG0586	Pfam SNARE associated Golgi protein
JHW28_RS25255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW28_RS25270	COG5322	oxidoreductase activity
JHW28_RS25270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHW28_RS25275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW28_RS25280	COG2771	luxR family
JHW28_RS25285	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS25305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHW28_RS25320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHW28_RS25325	COG0109	protoheme IX farnesyltransferase activity
JHW28_RS25335	COG1845	cytochrome c oxidase, subunit III
JHW28_RS25340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHW28_RS25345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHW28_RS25355	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHW28_RS25365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW28_RS25365	COG1017	nitric oxide dioxygenase activity
JHW28_RS25370	COG3604	Transcriptional regulator
JHW28_RS25375	COG0835	chemotaxis
JHW28_RS25375	COG0784	Response regulator, receiver
JHW28_RS25405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW28_RS25415	COG5002	protein histidine kinase activity
JHW28_RS25430	COG3706	GGDEF domain
JHW28_RS25430	COG4251	negative regulation of phosphorylation
JHW28_RS25430	COG2203	Gaf domain
JHW28_RS25430	COG5001	Diguanylate cyclase
JHW28_RS25435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JHW28_RS25440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHW28_RS25455	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHW28_RS25460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHW28_RS25465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHW28_RS25470	COG0772	Belongs to the SEDS family
JHW28_RS25475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JHW28_RS25480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHW28_RS25485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHW28_RS25490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHW28_RS25505	COG0275	rRNA processing
JHW28_RS25510	COG2001	Belongs to the MraZ family
JHW28_RS25525	COG3107	peptidoglycan biosynthetic process
JHW28_RS25530	COG0792	nuclease activity
JHW28_RS25535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHW28_RS25540	COG2823	Periplasmic or secreted lipoprotein
JHW28_RS25545	COG2969	positive regulation of protein catabolic process
JHW28_RS25550	COG0625	glutathione transferase activity
JHW28_RS25555	COG2857	Cytochrome c1
JHW28_RS25560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JHW28_RS25565	COG0723	plastoquinol--plastocyanin reductase activity
JHW28_RS25570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JHW28_RS25575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHW28_RS25580	COG0667	Aldo Keto reductase
JHW28_RS25585	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS25595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHW28_RS25600	COG0180	Tryptophanyl-tRNA synthetase
JHW28_RS25620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHW28_RS25635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JHW28_RS25645	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS25675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW28_RS25685	COG2771	luxR family
JHW28_RS25690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHW28_RS25705	COG0745	RESPONSE REGULATOR receiver
JHW28_RS25710	COG0642	Histidine kinase
JHW28_RS25715	COG2909	trisaccharide binding
JHW28_RS25730	COG0318	PFAM AMP-dependent synthetase and ligase
JHW28_RS25750	COG1280	lysine exporter protein (LysE YggA)
JHW28_RS25755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW28_RS25760	COG2813	Specifically methylates the guanine in position
JHW28_RS25765	COG2119	membrane
JHW28_RS25770	COG0501	Belongs to the peptidase M48B family
JHW28_RS25775	COG0840	transmembrane signaling receptor activity
JHW28_RS25780	COG2135	peptidase activity
JHW28_RS25840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JHW28_RS25845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHW28_RS25855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JHW28_RS25860	COG1090	epimerase
JHW28_RS25865	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
JHW28_RS25875	COG0789	Transcriptional regulator
JHW28_RS25880	COG0415	Belongs to the DNA photolyase family
JHW28_RS25895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JHW28_RS25900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHW28_RS25910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHW28_RS25915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JHW28_RS25925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JHW28_RS25930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JHW28_RS25940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHW28_RS25945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHW28_RS25950	COG0193	aminoacyl-tRNA hydrolase activity
JHW28_RS25965	COG0583	DNA-binding transcription factor activity
JHW28_RS25990	COG2258	MOSC domain
JHW28_RS25995	COG2223	nitrite transmembrane transporter activity
JHW28_RS26000	COG0583	DNA-binding transcription factor activity
JHW28_RS26005	COG3842	ATPase activity
JHW28_RS26010	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW28_RS26015	COG1177	transmembrane transport
JHW28_RS26085	COG0405	Gamma-glutamyltransferase
JHW28_RS26100	COG4680	protein conserved in bacteria
JHW28_RS26115	COG0789	Transcriptional regulator
JHW28_RS26130	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHW28_RS26145	COG3655	Transcriptional regulator
JHW28_RS26165	COG0662	Cupin 2, conserved barrel domain protein
JHW28_RS26175	COG0583	DNA-binding transcription factor activity
JHW28_RS26180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JHW28_RS26185	COG1028	Short-chain dehydrogenase reductase Sdr
JHW28_RS26190	COG0583	DNA-binding transcription factor activity
JHW28_RS26270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JHW28_RS26285	COG2031	fatty acid transporter
JHW28_RS26300	COG0288	reversible hydration of carbon dioxide
JHW28_RS26310	COG0456	acetyltransferase
JHW28_RS26335	COG3008	intermembrane lipid transfer
JHW28_RS26340	COG2995	paraquat-inducible protein a
JHW28_RS26345	COG2995	paraquat-inducible protein a
JHW28_RS26375	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
JHW28_RS26380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JHW28_RS26385	COG1183	phosphatidylcholine synthase activity
JHW28_RS26390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JHW28_RS26400	COG0028	Belongs to the TPP enzyme family
JHW28_RS26420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHW28_RS26450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JHW28_RS26455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW28_RS26460	COG4558	Periplasmic binding protein
JHW28_RS26470	COG1489	DNA binding
JHW28_RS26475	COG0436	Aminotransferase
JHW28_RS26485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHW28_RS26495	COG4191	Histidine kinase
JHW28_RS26515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JHW28_RS26520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JHW28_RS26530	COG0166	Belongs to the GPI family
JHW28_RS26535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHW28_RS26550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHW28_RS26560	COG2823	Periplasmic or secreted lipoprotein
JHW28_RS26575	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JHW28_RS26580	COG0237	dephospho-CoA kinase activity
JHW28_RS26585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JHW28_RS26605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHW28_RS26660	COG0728	peptidoglycan biosynthetic process
JHW28_RS26675	COG1252	NADH dehydrogenase
JHW28_RS26685	COG3188	usher protein
JHW28_RS26690	COG3121	Chaperone
JHW28_RS26700	COG2197	response regulator
JHW28_RS26710	COG5001	Diguanylate cyclase
JHW28_RS26710	COG3300	MHYT domain
JHW28_RS26745	COG0542	response to heat
JHW28_RS26775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS26815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JHW28_RS26820	COG1047	Peptidyl-prolyl cis-trans
JHW28_RS26825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JHW28_RS26830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHW28_RS26835	COG0196	riboflavin kinase activity
JHW28_RS26845	COG0268	Binds directly to 16S ribosomal RNA
JHW28_RS26850	COG3045	CreA protein
JHW28_RS26855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JHW28_RS26860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHW28_RS26865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JHW28_RS26870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHW28_RS26875	COG0142	geranyltranstransferase activity
JHW28_RS26880	COG2824	Alkylphosphonate utilization operon protein PhnA
JHW28_RS26885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHW28_RS26890	COG0545	Peptidyl-prolyl cis-trans isomerase
JHW28_RS26900	COG2862	Uncharacterized protein family, UPF0114
JHW28_RS26915	COG1067	ATP-dependent peptidase activity
JHW28_RS26935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW28_RS26945	COG0488	(ABC) transporter
JHW28_RS26955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHW28_RS26965	COG2186	Transcriptional regulator
JHW28_RS26975	COG0523	cobalamin synthesis protein
JHW28_RS26980	COG2879	small protein
JHW28_RS26985	COG1966	Carbon starvation protein
JHW28_RS26990	COG2020	methyltransferase activity
JHW28_RS27020	COG1970	mechanosensitive ion channel activity
JHW28_RS27030	COG2813	Specifically methylates the guanine in position
JHW28_RS27040	COG1294	oxidase, subunit
JHW28_RS27045	COG1271	oxidase subunit
JHW28_RS27070	COG2252	PERMEase
JHW28_RS27075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHW28_RS27080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHW28_RS27085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHW28_RS27090	COG3135	benzoate transporter
JHW28_RS27100	COG1309	transcriptional regulator
JHW28_RS27105	COG1082	Xylose isomerase domain protein TIM barrel
JHW28_RS27105	COG3185	4-Hydroxyphenylpyruvate dioxygenase
JHW28_RS27125	COG0673	inositol 2-dehydrogenase activity
JHW28_RS27135	COG1053	succinate dehydrogenase
JHW28_RS27140	COG3485	protocatechuate 3,4-dioxygenase
JHW28_RS27145	COG3485	protocatechuate 3,4-dioxygenase
JHW28_RS27150	COG0583	DNA-binding transcription factor activity
JHW28_RS27155	COG2321	neutral zinc metallopeptidase
JHW28_RS27170	COG1946	Acyl-CoA thioesterase
JHW28_RS27180	COG0123	including yeast histone deacetylase and acetoin utilization protein
JHW28_RS27190	COG0513	Belongs to the DEAD box helicase family
JHW28_RS27200	COG0697	spore germination
JHW28_RS27205	COG1522	sequence-specific DNA binding
JHW28_RS27210	COG1199	ATP-dependent helicase activity
JHW28_RS27210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHW28_RS27220	COG3416	Protein conserved in bacteria
JHW28_RS27235	COG1643	Atp-dependent helicase
JHW28_RS27255	COG1522	sequence-specific DNA binding
JHW28_RS27270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHW28_RS27275	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS27280	COG0784	Response regulator, receiver
JHW28_RS27280	COG2198	Histidine kinase
JHW28_RS27280	COG2205	protein histidine kinase activity
JHW28_RS27285	COG0351	phosphomethylpyrimidine kinase
JHW28_RS27290	COG0352	thiamine-phosphate diphosphorylase activity
JHW28_RS27295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHW28_RS27310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHW28_RS27315	COG1702	phosphate starvation-inducible protein PhoH
JHW28_RS27320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHW28_RS27325	COG4535	Mg2 and Co2 transporter CorC
JHW28_RS27330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JHW28_RS27345	COG0495	leucyl-tRNA aminoacylation
JHW28_RS27365	COG2951	lytic endotransglycosylase activity
JHW28_RS27370	COG1619	proteins homologs of microcin C7 resistance protein MccF
JHW28_RS27375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JHW28_RS27380	COG0321	lipoyl(octanoyl) transferase activity
JHW28_RS27385	COG2921	Belongs to the UPF0250 family
JHW28_RS27390	COG1686	Belongs to the peptidase S11 family
JHW28_RS27400	COG2951	lytic endotransglycosylase activity
JHW28_RS27405	COG0772	Belongs to the SEDS family
JHW28_RS27410	COG0768	penicillin binding
JHW28_RS27415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHW28_RS27425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHW28_RS27430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JHW28_RS27435	COG2094	Belongs to the DNA glycosylase MPG family
JHW28_RS27440	COG0586	Pfam SNARE associated Golgi protein
JHW28_RS27450	COG1346	cytolysis
JHW28_RS27470	COG0702	epimerase
JHW28_RS27485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHW28_RS27490	COG3284	Transcriptional regulator
JHW28_RS27500	COG0531	amino acid
JHW28_RS27505	COG4303	Ethanolamine ammonia lyase large subunit
JHW28_RS27510	COG4302	ethanolamine ammonia-lyase activity
JHW28_RS27515	COG0456	acetyltransferase
JHW28_RS27520	COG0586	Pfam SNARE associated Golgi protein
JHW28_RS27525	COG3228	Belongs to the MtfA family
JHW28_RS27530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JHW28_RS27545	COG2070	2-Nitropropane dioxygenase
JHW28_RS27555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JHW28_RS27565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHW28_RS27570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHW28_RS27570	COG0473	3-isopropylmalate dehydrogenase activity
JHW28_RS27575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHW28_RS27585	COG2814	Major facilitator Superfamily
JHW28_RS27600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS27615	COG0583	DNA-binding transcription factor activity
JHW28_RS27625	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHW28_RS27630	COG3657	addiction module killer protein
JHW28_RS27640	COG3321	synthase
JHW28_RS27640	COG0604	alcohol dehydrogenase
JHW28_RS27645	COG0640	Transcriptional regulator
JHW28_RS27655	COG1722	exodeoxyribonuclease VII activity
JHW28_RS27660	COG0142	geranyltranstransferase activity
JHW28_RS27665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHW28_RS27670	COG4206	TonB-dependent receptor
JHW28_RS27685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHW28_RS27695	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHW28_RS27705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHW28_RS27710	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JHW28_RS27725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHW28_RS27725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHW28_RS27730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHW28_RS27740	COG2264	protein methyltransferase activity
JHW28_RS27745	COG3118	belongs to the thioredoxin family
JHW28_RS27775	COG3047	cAMP biosynthetic process
JHW28_RS27790	COG1201	RNA secondary structure unwinding
JHW28_RS27795	COG2814	Major facilitator Superfamily
JHW28_RS27805	COG3568	Endonuclease Exonuclease Phosphatase
JHW28_RS27810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW28_RS27815	COG0392	lysyltransferase activity
JHW28_RS27835	COG1335	isochorismatase
JHW28_RS27840	COG0629	single-stranded DNA binding
JHW28_RS27845	COG2814	Major facilitator Superfamily
JHW28_RS27850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHW28_RS27855	COG2193	ferroxidase activity
JHW28_RS27865	COG0203	ribosomal protein L17
JHW28_RS27870	COG0202	RNA polymerase activity
JHW28_RS27875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JHW28_RS27880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHW28_RS27885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHW28_RS27890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHW28_RS27900	COG0200	Binds to the 23S rRNA
JHW28_RS27905	COG1841	ribosomal large subunit assembly
JHW28_RS27910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JHW28_RS27915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JHW28_RS27920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JHW28_RS27925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHW28_RS27930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHW28_RS27935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JHW28_RS27940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JHW28_RS27945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHW28_RS27950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHW28_RS27955	COG0255	Belongs to the universal ribosomal protein uL29 family
JHW28_RS27960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JHW28_RS27965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JHW28_RS27970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHW28_RS27975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JHW28_RS27980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JHW28_RS27985	COG0089	rRNA binding
JHW28_RS27990	COG0088	Forms part of the polypeptide exit tunnel
JHW28_RS27995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHW28_RS28000	COG0051	transcription antitermination factor activity, RNA binding
JHW28_RS28005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHW28_RS28010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHW28_RS28015	COG0049	tRNA binding
JHW28_RS28020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JHW28_RS28025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JHW28_RS28030	COG0085	RNA polymerase activity
JHW28_RS28035	COG0222	ribosome binding
JHW28_RS28040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JHW28_RS28045	COG0081	regulation of translation
JHW28_RS28050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JHW28_RS28070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHW28_RS28095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JHW28_RS28130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHW28_RS28135	COG0739	heme binding
JHW28_RS28140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JHW28_RS28145	COG0316	Belongs to the HesB IscA family
JHW28_RS28150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHW28_RS28155	COG1981	membrane
JHW28_RS28170	COG4221	oxidoreductase activity
JHW28_RS28175	COG0537	adenosine 5'-monophosphoramidase activity
JHW28_RS28180	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
JHW28_RS28185	COG1765	OsmC-like protein
JHW28_RS28200	COG0134	indole-3-glycerol-phosphate synthase activity
JHW28_RS28205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHW28_RS28210	COG0512	Glutamine amidotransferase of anthranilate synthase
JHW28_RS28220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHW28_RS28225	COG0546	phosphoglycolate phosphatase activity
JHW28_RS28230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHW28_RS28235	COG1454	alcohol dehydrogenase
JHW28_RS28245	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW28_RS28255	COG3842	ATPase activity
JHW28_RS28260	COG2197	response regulator
JHW28_RS28265	COG4585	Histidine kinase
JHW28_RS28275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHW28_RS28280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JHW28_RS28285	COG3178	'Phosphotransferase
JHW28_RS28290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JHW28_RS28295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHW28_RS28300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JHW28_RS28305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHW28_RS28310	COG2967	ApaG domain
JHW28_RS28315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHW28_RS28320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHW28_RS28325	COG2766	serine protein kinase
JHW28_RS28330	COG2718	Belongs to the UPF0229 family
JHW28_RS28335	COG2719	SpoVR family
JHW28_RS28340	COG0617	tRNA 3'-terminal CCA addition
JHW28_RS28350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHW28_RS28355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JHW28_RS28360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JHW28_RS28365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JHW28_RS28370	COG0358	DNA primase activity
JHW28_RS28375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHW28_RS28410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHW28_RS28415	COG1025	Belongs to the peptidase M16 family
JHW28_RS28425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JHW28_RS28430	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
JHW28_RS28440	COG0535	radical SAM domain protein
JHW28_RS28465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHW28_RS28470	COG2258	MOSC domain
JHW28_RS28475	COG0583	DNA-binding transcription factor activity
JHW28_RS28480	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS28485	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS28490	COG3706	GGDEF domain
JHW28_RS28495	COG1960	acyl-CoA dehydrogenase activity
JHW28_RS28515	COG1073	alpha beta
JHW28_RS28515	COG2226	methyltransferase
JHW28_RS28520	COG0156	8-amino-7-oxononanoate synthase activity
JHW28_RS28525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JHW28_RS28535	COG2005	Transcriptional regulator
JHW28_RS28535	COG3585	molybdate ion transport
JHW28_RS28545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JHW28_RS28560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JHW28_RS28580	COG1595	DNA-templated transcription, initiation
JHW28_RS28585	COG3712	iron ion homeostasis
JHW28_RS28590	COG4774	siderophore transport
JHW28_RS28610	COG0625	glutathione transferase activity
JHW28_RS28615	COG4452	Inner membrane protein CreD
JHW28_RS28620	COG2205	protein histidine kinase activity
JHW28_RS28625	COG0745	RESPONSE REGULATOR receiver
JHW28_RS28630	COG0189	ligase activity
JHW28_RS28630	COG4067	protein conserved in archaea
JHW28_RS28635	COG0204	Acyl-transferase
JHW28_RS28650	COG1063	alcohol dehydrogenase
JHW28_RS28680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHW28_RS28695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHW28_RS28710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW28_RS28710	COG1017	nitric oxide dioxygenase activity
JHW28_RS28715	COG4638	Rieske (2fe-2S)
JHW28_RS28725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JHW28_RS28730	COG2181	nitrate reductase activity
JHW28_RS28730	COG0247	lactate metabolic process
JHW28_RS28735	COG1902	pentaerythritol trinitrate reductase activity
JHW28_RS28735	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHW28_RS28780	COG3246	L-lysine catabolic process to acetate
JHW28_RS28785	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW28_RS28815	COG1760	l-serine dehydratase
JHW28_RS28825	COG4176	ABC-type proline glycine betaine transport system permease component
JHW28_RS28830	COG4175	Glycine betaine
JHW28_RS28835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHW28_RS28840	COG1309	transcriptional regulator
JHW28_RS28845	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS28850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JHW28_RS28860	COG0312	modulator of DNA gyrase
JHW28_RS28865	COG0477	Major facilitator Superfamily
JHW28_RS28870	COG0513	Belongs to the DEAD box helicase family
JHW28_RS28875	COG2081	HI0933 family
JHW28_RS28880	COG1289	transmembrane transporter activity
JHW28_RS28890	COG2153	protein acetylation
JHW28_RS28900	COG1451	nucleotide metabolic process
JHW28_RS28930	COG0126	phosphoglycerate kinase activity
JHW28_RS28935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHW28_RS28945	COG4106	trans-aconitate 2-methyltransferase activity
JHW28_RS28950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHW28_RS28955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHW28_RS28960	COG1422	Protein of unknown function (DUF1090)
JHW28_RS28985	COG2814	Major facilitator Superfamily
JHW28_RS28995	COG2116	formate transmembrane transporter activity
JHW28_RS29005	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JHW28_RS29010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JHW28_RS29025	COG0513	Belongs to the DEAD box helicase family
JHW28_RS29030	COG2353	YceI-like domain
JHW28_RS29035	COG3038	cytochrome b561
JHW28_RS29045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHW28_RS29070	COG1272	protein, Hemolysin III
JHW28_RS29090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JHW28_RS29110	COG3052	prosthetic group binding
JHW28_RS29115	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
JHW28_RS29135	COG0643	Histidine kinase
JHW28_RS29135	COG0784	Response regulator, receiver
JHW28_RS29135	COG2198	Histidine kinase
JHW28_RS29160	COG0189	ligase activity
JHW28_RS29170	COG1678	Uncharacterized ACR, COG1678
JHW28_RS29175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHW28_RS29180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JHW28_RS29185	COG0540	Belongs to the ATCase OTCase family
JHW28_RS29190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JHW28_RS29200	COG0791	NLP P60 protein
JHW28_RS29225	COG1872	DUF167
JHW28_RS29230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JHW28_RS29235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JHW28_RS29235	COG2813	Specifically methylates the guanine in position
JHW28_RS29245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JHW28_RS29250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHW28_RS29260	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
JHW28_RS29265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHW28_RS29270	COG2022	thiamine diphosphate biosynthetic process
JHW28_RS29280	COG2363	Small membrane protein
JHW28_RS29285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHW28_RS29295	COG2177	Part of the ABC transporter FtsEX involved in
JHW28_RS29300	COG2884	Cell division ATP-binding protein ftsE
JHW28_RS29305	COG0552	protein localization to endoplasmic reticulum
JHW28_RS29310	COG0612	Peptidase, M16
JHW28_RS29315	COG0612	Peptidase, M16
JHW28_RS29320	COG0742	ribosomal rna small subunit methyltransferase
JHW28_RS29355	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JHW28_RS29360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JHW28_RS29365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHW28_RS29370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHW28_RS29380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHW28_RS29390	COG0129	dihydroxy-acid dehydratase activity
JHW28_RS29415	COG1823	symporter activity
JHW28_RS29430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHW28_RS29445	COG1840	ABC-type Fe3 transport system, periplasmic component
JHW28_RS29450	COG1178	ABC-type Fe3 transport system permease component
JHW28_RS29455	COG3842	ATPase activity
JHW28_RS29460	COG0583	DNA-binding transcription factor activity
JHW28_RS29470	COG0789	Transcriptional regulator
JHW28_RS29475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHW28_RS29480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHW28_RS29485	COG0730	response to heat
JHW28_RS29495	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
JHW28_RS29500	COG0494	nUDIX hydrolase
JHW28_RS29515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JHW28_RS29520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHW28_RS29525	COG2234	aminopeptidase activity
JHW28_RS29530	COG3204	pilus organization
JHW28_RS29535	COG3204	pilus organization
JHW28_RS29540	COG0179	Fumarylacetoacetate (FAA) hydrolase
JHW28_RS29545	COG0277	FAD linked oxidase domain protein
JHW28_RS29550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW28_RS29560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS29565	COG1683	Conserved Protein
JHW28_RS29595	COG1177	transmembrane transport
JHW28_RS29600	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW28_RS29605	COG3842	ATPase activity
JHW28_RS29625	COG0174	glutamine synthetase
JHW28_RS29630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHW28_RS29635	COG0174	glutamine synthetase
JHW28_RS29650	COG1116	anion transmembrane transporter activity
JHW28_RS29655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW28_RS29660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW28_RS29665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW28_RS29670	COG0431	NADPH-dependent FMN reductase
JHW28_RS29675	COG0450	alkyl hydroperoxide reductase
JHW28_RS29685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHW28_RS29685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHW28_RS29690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHW28_RS29700	COG1522	sequence-specific DNA binding
JHW28_RS29710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHW28_RS29720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHW28_RS29720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHW28_RS29725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHW28_RS29740	COG0509	glycine decarboxylation via glycine cleavage system
JHW28_RS29745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JHW28_RS29750	COG1178	ABC-type Fe3 transport system permease component
JHW28_RS29760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW28_RS29765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW28_RS29770	COG0006	proline dipeptidase activity
JHW28_RS29775	COG3079	Belongs to the UPF0149 family
JHW28_RS29795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHW28_RS29810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW28_RS29815	COG0842	Transport permease protein
JHW28_RS29815	COG1129	ABC transporter
JHW28_RS29820	COG0842	Transport permease protein
JHW28_RS29830	COG0604	alcohol dehydrogenase
JHW28_RS29835	COG2271	Major facilitator Superfamily
JHW28_RS29850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHW28_RS29865	COG2186	Transcriptional regulator
JHW28_RS29870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS29875	COG0765	amino acid transport
JHW28_RS29880	COG0765	amino acid transport
JHW28_RS29885	COG1126	abc transporter atp-binding protein
JHW28_RS29890	COG0248	Ppx GppA phosphatase
JHW28_RS29895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JHW28_RS29905	COG0586	Pfam SNARE associated Golgi protein
JHW28_RS29915	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JHW28_RS29920	COG1671	Belongs to the UPF0178 family
JHW28_RS29925	COG0672	)-iron permease
JHW28_RS29930	COG1280	lysine exporter protein (LysE YggA)
JHW28_RS29940	COG0488	(ABC) transporter
JHW28_RS29965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHW28_RS29985	COG0181	hydroxymethylbilane synthase activity
JHW28_RS29995	COG0165	Argininosuccinate lyase
JHW28_RS30000	COG0625	glutathione transferase activity
JHW28_RS30015	COG3072	Adenylate cyclase
JHW28_RS30020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW28_RS30030	COG1965	Belongs to the frataxin family
JHW28_RS30040	COG0019	diaminopimelate decarboxylase activity
JHW28_RS30045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHW28_RS30055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JHW28_RS30060	COG1011	Hydrolase
JHW28_RS30070	COG0432	Pfam Uncharacterised protein family UPF0047
JHW28_RS30075	COG0004	ammonium transporteR
JHW28_RS30080	COG0347	Belongs to the P(II) protein family
JHW28_RS30095	COG0529	Catalyzes the synthesis of activated sulfate
JHW28_RS30105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW28_RS30110	COG3848	Pyruvate phosphate dikinase
JHW28_RS30110	COG0574	Belongs to the PEP-utilizing enzyme family
JHW28_RS30115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHW28_RS30120	COG1213	nucleotidyl transferase
JHW28_RS30125	COG0606	chelatase, subunit chli
JHW28_RS30155	COG0583	DNA-binding transcription factor activity
JHW28_RS30160	COG0534	Mate efflux family protein
JHW28_RS30175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHW28_RS30180	COG0427	acetyl-CoA hydrolase
JHW28_RS30195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHW28_RS30200	COG0251	oxidation-reduction process
JHW28_RS30205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS30220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW28_RS30230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW28_RS30235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW28_RS30245	COG1012	belongs to the aldehyde dehydrogenase family
JHW28_RS30255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JHW28_RS30260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHW28_RS30265	COG0747	negative chemotaxis
JHW28_RS30270	COG2003	Belongs to the UPF0758 family
JHW28_RS30275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHW28_RS30280	COG0756	dUTP diphosphatase activity
JHW28_RS30285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHW28_RS30290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHW28_RS30295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JHW28_RS30300	COG0708	Exodeoxyribonuclease III
JHW28_RS30310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JHW28_RS30315	COG1561	YicC-like family, N-terminal region
JHW28_RS30320	COG0194	GDP metabolic process
JHW28_RS30325	COG1758	RNA polymerase activity
JHW28_RS30330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHW28_RS30355	COG0848	biopolymer transport protein
JHW28_RS30365	COG0583	DNA-binding transcription factor activity
JHW28_RS30370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JHW28_RS30435	COG0515	serine threonine protein kinase
JHW28_RS30555	COG3161	chorismate lyase activity
JHW28_RS30560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JHW28_RS30580	COG1253	flavin adenine dinucleotide binding
JHW28_RS30585	COG0739	heme binding
JHW28_RS30605	COG0704	Plays a role in the regulation of phosphate uptake
JHW28_RS30610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHW28_RS30615	COG0573	inorganic phosphate transmembrane transporter activity
JHW28_RS30630	COG0477	Major facilitator Superfamily
JHW28_RS30635	COG1607	acyl-coa hydrolase
JHW28_RS30665	COG0583	DNA-binding transcription factor activity
JHW28_RS30670	COG1027	Aspartate ammonia-lyase
JHW28_RS30685	COG1115	amino acid carrier protein
JHW28_RS30690	COG0252	asparaginase activity
JHW28_RS30715	COG2391	methyltransferase activity
JHW28_RS30745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW28_RS30750	COG0765	amino acid transport
JHW28_RS30765	COG5016	pyruvate
JHW28_RS30765	COG0511	ligase activity, forming carbon-carbon bonds
JHW28_RS30770	COG0439	Biotin carboxylase
JHW28_RS30775	COG0583	DNA-binding transcription factor activity
JHW28_RS30795	COG0210	DNA helicase
JHW28_RS30815	COG4651	solute:proton antiporter activity
JHW28_RS30815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHW28_RS30820	COG1607	acyl-coa hydrolase
JHW28_RS30825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHW28_RS30835	COG0523	cobalamin synthesis protein
JHW28_RS30860	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHW28_RS30865	COG1469	GTP cyclohydrolase I activity
JHW28_RS30870	COG1121	(ABC) transporter
JHW28_RS30880	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHW28_RS30885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHW28_RS30895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JHW28_RS30900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHW28_RS30910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW28_RS30915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHW28_RS30920	COG2217	Heavy metal translocating P-type atpase
JHW28_RS30940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHW28_RS30945	COG2267	carboxylic ester hydrolase activity
JHW28_RS30950	COG0671	phosphoesterase, PA-phosphatase related
JHW28_RS30950	COG2453	phosphatase
JHW28_RS30965	COG4589	Belongs to the CDS family
JHW28_RS30970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW28_RS30980	COG1280	lysine exporter protein (LysE YggA)
JHW28_RS30985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW28_RS30990	COG2755	lipolytic protein G-D-S-L family
JHW28_RS30990	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JHW28_RS30995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW28_RS31040	COG0438	transferase activity, transferring glycosyl groups
JHW28_RS31055	COG0625	glutathione transferase activity
JHW28_RS31060	COG0583	DNA-binding transcription factor activity
JHW28_RS31065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW28_RS31080	COG0494	nUDIX hydrolase
JHW28_RS31085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHW28_RS31100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW28_RS31105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHW28_RS31110	COG0494	nUDIX hydrolase
JHW28_RS31125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHW28_RS31130	COG1349	DNA-binding transcription factor activity
JHW28_RS31135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHW28_RS31140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHW28_RS31145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHW28_RS31150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHW28_RS31155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHW28_RS31160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHW28_RS31165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JHW28_RS31175	COG0356	it plays a direct role in the translocation of protons across the membrane
JHW28_RS31180	COG3312	ion transport
JHW28_RS31185	COG1475	DNA binding
JHW28_RS31190	COG1192	Involved in chromosome partitioning
JHW28_RS31195	COG0357	Ribosomal RNA small subunit methyltransferase G
JHW28_RS31200	COG0445	tRNA wobble uridine modification
JHW28_RS31205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHW28_RS31210	COG0706	membrane insertase activity
JHW28_RS31215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JHW28_RS31220	COG0594	ribonuclease P activity
JHW28_RS31225	COG0230	Belongs to the bacterial ribosomal protein bL34 family