locus-tag	class	description
C4K38_RS00010	COG0592	DNA-directed DNA polymerase activity
C4K38_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K38_RS00020	COG0187	DNA topoisomerase II activity
C4K38_RS00045	COG5002	protein histidine kinase activity
C4K38_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4K38_RS00060	COG0751	glycine-tRNA ligase activity
C4K38_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
C4K38_RS00070	COG2818	Glycosylase
C4K38_RS00090	COG0569	domain protein
C4K38_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4K38_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K38_RS00105	COG0242	peptide deformylase activity
C4K38_RS00115	COG0758	DNA mediated transformation
C4K38_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
C4K38_RS00130	COG0408	coproporphyrinogen oxidase activity
C4K38_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K38_RS00150	COG3119	arylsulfatase activity
C4K38_RS00175	COG0159	tryptophan synthase activity
C4K38_RS00180	COG0133	tryptophan synthase activity
C4K38_RS00195	COG3360	Dodecin
C4K38_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS00210	COG1764	response to oxidative stress
C4K38_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4K38_RS00250	COG0339	signal peptide processing
C4K38_RS00255	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4K38_RS00290	COG0659	secondary active sulfate transmembrane transporter activity
C4K38_RS00300	COG1565	acr, cog1565
C4K38_RS00300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K38_RS00305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K38_RS00310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4K38_RS00340	COG0109	protoheme IX farnesyltransferase activity
C4K38_RS00355	COG2011	ABC-type metal ion transport system permease component
C4K38_RS00360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K38_RS00370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K38_RS00375	COG1121	(ABC) transporter
C4K38_RS00380	COG0735	belongs to the Fur family
C4K38_RS00385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4K38_RS00405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4K38_RS00410	COG3245	cytochrome
C4K38_RS00420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K38_RS00435	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K38_RS00440	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K38_RS00445	COG5002	protein histidine kinase activity
C4K38_RS00450	COG2204	response regulator
C4K38_RS00460	COG5487	UPF0391 membrane protein
C4K38_RS00470	COG1301	dicarboxylic acid transport
C4K38_RS00475	COG0700	Nucleoside recognition
C4K38_RS00490	COG1127	ABC transporter
C4K38_RS00495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K38_RS00505	COG0612	Peptidase, M16
C4K38_RS00510	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K38_RS00515	COG0861	Integral membrane protein TerC family
C4K38_RS00520	COG2851	Citrate transporter
C4K38_RS00560	COG0427	acetyl-CoA hydrolase
C4K38_RS00580	COG0583	DNA-binding transcription factor activity
C4K38_RS00585	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS00640	COG3712	iron ion homeostasis
C4K38_RS00645	COG1595	DNA-templated transcription, initiation
C4K38_RS00650	COG0840	transmembrane signaling receptor activity
C4K38_RS00680	COG1802	Transcriptional regulator
C4K38_RS00690	COG3300	MHYT domain
C4K38_RS00690	COG5001	Diguanylate cyclase
C4K38_RS00705	COG1538	Outer membrane efflux protein
C4K38_RS00715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS00720	COG2175	clavaminate synthase activity
C4K38_RS00730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K38_RS00735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K38_RS00820	COG0529	Catalyzes the synthesis of activated sulfate
C4K38_RS00835	COG0330	HflC and HflK could
C4K38_RS00870	COG1289	transmembrane transporter activity
C4K38_RS00880	COG1566	PFAM secretion protein HlyD family protein
C4K38_RS00895	COG5339	Protein conserved in bacteria
C4K38_RS00900	COG0457	Tetratricopeptide repeat
C4K38_RS00905	COG0726	polysaccharide deacetylase
C4K38_RS00905	COG1649	PFAM Uncharacterised BCR, COG1649
C4K38_RS00910	COG1215	transferase activity, transferring glycosyl groups
C4K38_RS00920	COG1881	PFAM PEBP family protein
C4K38_RS00925	COG2304	oxidoreductase activity
C4K38_RS00930	COG1595	DNA-templated transcription, initiation
C4K38_RS01005	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K38_RS01015	COG0745	RESPONSE REGULATOR receiver
C4K38_RS01020	COG2199	diguanylate cyclase activity
C4K38_RS01040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4K38_RS01050	COG4208	sulfate ABC transporter
C4K38_RS01055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4K38_RS01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K38_RS01095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS01120	COG4771	TonB-dependent receptor
C4K38_RS01185	COG3209	COG3209 Rhs family protein
C4K38_RS01205	COG2807	transmembrane transport
C4K38_RS01210	COG0590	tRNA wobble adenosine to inosine editing
C4K38_RS01220	COG0583	DNA-binding transcription factor activity
C4K38_RS01255	COG0765	amino acid transport
C4K38_RS01260	COG0765	amino acid transport
C4K38_RS01265	COG1126	abc transporter atp-binding protein
C4K38_RS01270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS01275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K38_RS01280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS01290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS01305	COG2011	ABC-type metal ion transport system permease component
C4K38_RS01310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K38_RS01340	COG1126	abc transporter atp-binding protein
C4K38_RS01345	COG0765	amino acid transport
C4K38_RS01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS01355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4K38_RS01360	COG1045	serine acetyltransferase
C4K38_RS01365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K38_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS01380	COG0583	DNA-binding transcription factor activity
C4K38_RS01400	COG0667	Aldo Keto reductase
C4K38_RS01410	COG2175	clavaminate synthase activity
C4K38_RS01415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K38_RS01420	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K38_RS01425	COG4521	taurine ABC transporter
C4K38_RS01430	COG2918	glutathione biosynthetic process
C4K38_RS01440	COG2183	response to ionizing radiation
C4K38_RS01450	COG2205	protein histidine kinase activity
C4K38_RS01455	COG0189	ligase activity
C4K38_RS01460	COG0189	ligase activity
C4K38_RS01460	COG4067	protein conserved in archaea
C4K38_RS01465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4K38_RS01475	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4K38_RS01480	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4K38_RS01530	COG0514	ATP-dependent DNA helicase (RecQ)
C4K38_RS01535	COG1024	Enoyl-CoA hydratase
C4K38_RS01535	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS01540	COG0824	Thioesterase
C4K38_RS01550	COG0243	molybdopterin cofactor binding
C4K38_RS01555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4K38_RS01565	COG1652	LysM domain
C4K38_RS01570	COG1011	Hydrolase
C4K38_RS01575	COG0494	nUDIX hydrolase
C4K38_RS01610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K38_RS01620	COG2957	Belongs to the agmatine deiminase family
C4K38_RS01680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K38_RS01685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K38_RS01690	COG1845	cytochrome c oxidase, subunit III
C4K38_RS01695	COG1845	cytochrome c oxidase, subunit III
C4K38_RS01715	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4K38_RS01765	COG4215	(ABC) transporter
C4K38_RS01835	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4K38_RS01840	COG1194	a g-specific adenine glycosylase
C4K38_RS01855	COG2223	nitrite transmembrane transporter activity
C4K38_RS01860	COG0131	Imidazoleglycerol-phosphate dehydratase
C4K38_RS01865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K38_RS01875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4K38_RS01880	COG0107	imidazoleglycerol-phosphate synthase activity
C4K38_RS01890	COG2861	carbohydrate metabolic process
C4K38_RS01895	COG0793	Belongs to the peptidase S41A family
C4K38_RS01900	COG4942	peptidase
C4K38_RS01905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4K38_RS01920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4K38_RS01945	COG3852	Histidine kinase
C4K38_RS01950	COG0477	Major facilitator Superfamily
C4K38_RS01955	COG0583	DNA-binding transcription factor activity
C4K38_RS01960	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS01965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K38_RS01970	COG1024	Enoyl-CoA hydratase
C4K38_RS01975	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS01980	COG0183	Belongs to the thiolase family
C4K38_RS02015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K38_RS02015	COG0301	tRNA thio-modification
C4K38_RS02020	COG1217	gtp-binding protein TYPA
C4K38_RS02030	COG0058	SHG alpha-glucan phosphorylase activity
C4K38_RS02035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4K38_RS02075	COG0402	S-adenosylhomocysteine deaminase activity
C4K38_RS02080	COG2188	Transcriptional regulator
C4K38_RS02090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4K38_RS02095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K38_RS02105	COG4176	ABC-type proline glycine betaine transport system permease component
C4K38_RS02110	COG0517	IMP dehydrogenase activity
C4K38_RS02110	COG4175	Glycine betaine
C4K38_RS02115	COG2986	histidine ammonia-lyase
C4K38_RS02120	COG2986	histidine ammonia-lyase
C4K38_RS02130	COG1228	amidohydrolase
C4K38_RS02140	COG0596	Alpha beta hydrolase
C4K38_RS02145	COG1490	D-aminoacyl-tRNA deacylase activity
C4K38_RS02150	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K38_RS02155	COG2943	transferase activity, transferring hexosyl groups
C4K38_RS02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS02165	COG0765	amino acid transport
C4K38_RS02175	COG0840	transmembrane signaling receptor activity
C4K38_RS02190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K38_RS02195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K38_RS02200	COG0140	phosphoribosyl-ATP diphosphatase activity
C4K38_RS02205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K38_RS02210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K38_RS02220	COG2226	methyltransferase
C4K38_RS02265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4K38_RS02270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4K38_RS02280	COG0018	arginyl-trna synthetase
C4K38_RS02285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4K38_RS02290	COG0254	rRNA binding
C4K38_RS02300	COG0281	malic enzyme
C4K38_RS02335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K38_RS02340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K38_RS02355	COG0067	glutamate synthase
C4K38_RS02355	COG0069	glutamate synthase activity
C4K38_RS02355	COG0070	glutamate synthase
C4K38_RS02360	COG0493	'glutamate synthase
C4K38_RS02365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4K38_RS02370	COG3111	PFAM Bacterial OB fold (BOF) protein
C4K38_RS02375	COG2814	Major facilitator Superfamily
C4K38_RS02380	COG0583	DNA-binding transcription factor activity
C4K38_RS02400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K38_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS02415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K38_RS02425	COG2226	methyltransferase
C4K38_RS02430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K38_RS02455	COG2986	histidine ammonia-lyase
C4K38_RS02480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K38_RS02485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K38_RS02500	COG1192	Involved in chromosome partitioning
C4K38_RS02505	COG3118	belongs to the thioredoxin family
C4K38_RS02510	COG4680	protein conserved in bacteria
C4K38_RS02520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K38_RS02525	COG1196	nuclear chromosome segregation
C4K38_RS02525	COG3264	Mechanosensitive ion channel
C4K38_RS02530	COG3263	regulation of cellular component size
C4K38_RS02550	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS02555	COG0506	proline dehydrogenase activity
C4K38_RS02555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K38_RS02555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K38_RS02560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K38_RS02565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4K38_RS02570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K38_RS02590	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4K38_RS02595	COG0859	PFAM glycosyl transferase family 9
C4K38_RS02600	COG0859	PFAM glycosyl transferase family 9
C4K38_RS02605	COG0438	transferase activity, transferring glycosyl groups
C4K38_RS02630	COG2192	nodulation
C4K38_RS02635	COG0438	transferase activity, transferring glycosyl groups
C4K38_RS02660	COG0438	transferase activity, transferring glycosyl groups
C4K38_RS02675	COG1132	(ABC) transporter
C4K38_RS02695	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4K38_RS02695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4K38_RS02705	COG0667	Aldo Keto reductase
C4K38_RS02725	COG1519	Transferase
C4K38_RS02730	COG1538	Outer membrane efflux protein
C4K38_RS02735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4K38_RS02750	COG0494	nUDIX hydrolase
C4K38_RS02760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4K38_RS02765	COG3150	esterase
C4K38_RS02800	COG3830	Belongs to the UPF0237 family
C4K38_RS02800	COG0560	Phosphoserine phosphatase
C4K38_RS02805	COG0688	phosphatidylethanolamine metabolic process
C4K38_RS02830	COG1162	GTPase activity
C4K38_RS02835	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4K38_RS02840	COG2860	membrane
C4K38_RS02850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4K38_RS02850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4K38_RS02855	COG0802	atpase or kinase
C4K38_RS02860	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K38_RS02865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K38_RS02870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4K38_RS02875	COG1923	regulation of RNA biosynthetic process
C4K38_RS02880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4K38_RS02885	COG0330	HflC and HflK could
C4K38_RS02890	COG0330	HflC and HflK could
C4K38_RS02895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4K38_RS02900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4K38_RS02905	COG0840	transmembrane signaling receptor activity
C4K38_RS02910	COG1178	ABC-type Fe3 transport system permease component
C4K38_RS02915	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K38_RS02930	COG0557	exoribonuclease II activity
C4K38_RS02935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4K38_RS02940	COG0360	Binds together with S18 to 16S ribosomal RNA
C4K38_RS02945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4K38_RS02955	COG0359	binds to the 23S rRNA
C4K38_RS02960	COG0305	Participates in initiation and elongation during chromosome replication
C4K38_RS02965	COG1032	radical SAM domain protein
C4K38_RS02980	COG2308	Evidence 4 Homologs of previously reported genes of
C4K38_RS02980	COG2307	Protein conserved in bacteria
C4K38_RS03010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4K38_RS03015	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4K38_RS03020	COG0583	DNA-binding transcription factor activity
C4K38_RS03025	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS03040	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4K38_RS03065	COG4221	oxidoreductase activity
C4K38_RS03085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4K38_RS03090	COG0830	nickel cation binding
C4K38_RS03095	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4K38_RS03110	COG2982	Protein involved in outer membrane biogenesis
C4K38_RS03115	COG0583	DNA-binding transcription factor activity
C4K38_RS03120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K38_RS03130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4K38_RS03135	COG0697	spore germination
C4K38_RS03140	COG2207	Transcriptional regulator
C4K38_RS03155	COG0443	Heat shock 70 kDa protein
C4K38_RS03160	COG0484	heat shock protein binding
C4K38_RS03165	COG0789	Transcriptional regulator
C4K38_RS03175	COG0804	urea catabolic process
C4K38_RS03180	COG0832	Belongs to the urease beta subunit family
C4K38_RS03195	COG0831	urea catabolic process
C4K38_RS03200	COG0829	nickel cation binding
C4K38_RS03210	COG0411	ABC transporter
C4K38_RS03230	COG0683	leucine binding
C4K38_RS03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K38_RS03245	COG1120	ATPase activity
C4K38_RS03285	COG3657	addiction module killer protein
C4K38_RS03295	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4K38_RS03305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K38_RS03335	COG2095	MarC family integral membrane protein
C4K38_RS03345	COG0151	Belongs to the GarS family
C4K38_RS03350	COG0138	bifunctional purine biosynthesis protein purh
C4K38_RS03360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K38_RS03370	COG2264	protein methyltransferase activity
C4K38_RS03385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K38_RS03415	COG0023	Translation Initiation Factor
C4K38_RS03420	COG1166	arginine decarboxylase activity
C4K38_RS03425	COG0534	Mate efflux family protein
C4K38_RS03430	COG2373	Large extracellular alpha-helical protein
C4K38_RS03440	COG4953	penicillin-binding protein 1C
C4K38_RS03450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K38_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS03560	COG0840	transmembrane signaling receptor activity
C4K38_RS03575	COG2217	Heavy metal translocating P-type atpase
C4K38_RS03605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4K38_RS03610	COG0583	DNA-binding transcription factor activity
C4K38_RS03615	COG0477	Major facilitator Superfamily
C4K38_RS03620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4K38_RS03635	COG0387	Pfam Sodium calcium exchanger
C4K38_RS03660	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4K38_RS03665	COG4603	Belongs to the binding-protein-dependent transport system permease family
C4K38_RS03670	COG3845	ABC transporter
C4K38_RS03680	COG1309	transcriptional regulator
C4K38_RS03685	COG2233	PERMEase
C4K38_RS03735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4K38_RS03740	COG1074	ATP-dependent DNA helicase activity
C4K38_RS03745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K38_RS03755	COG2199	diguanylate cyclase activity
C4K38_RS03830	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4K38_RS03835	COG3483	tryptophan 2,3-dioxygenase activity
C4K38_RS03840	COG1113	amino acid transport
C4K38_RS03845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K38_RS03845	COG0543	2 iron, 2 sulfur cluster binding
C4K38_RS03850	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4K38_RS03855	COG4638	Rieske (2fe-2S)
C4K38_RS03865	COG1522	sequence-specific DNA binding
C4K38_RS03875	COG1113	amino acid transport
C4K38_RS03880	COG0583	DNA-binding transcription factor activity
C4K38_RS03895	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K38_RS03900	COG0583	DNA-binding transcription factor activity
C4K38_RS03915	COG2610	gluconate transmembrane transporter activity
C4K38_RS03925	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4K38_RS03955	COG0840	transmembrane signaling receptor activity
C4K38_RS03990	COG4160	amino acid transport
C4K38_RS04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS04005	COG1473	amidohydrolase
C4K38_RS04010	COG0583	DNA-binding transcription factor activity
C4K38_RS04025	COG1309	transcriptional regulator
C4K38_RS04050	COG0583	DNA-binding transcription factor activity
C4K38_RS04100	COG0464	growth
C4K38_RS04120	COG4983	Phage plasmid primase, P4 family domain protein
C4K38_RS04140	COG0582	viral genome integration into host DNA
C4K38_RS04170	COG0247	lactate metabolic process
C4K38_RS04175	COG1620	l-lactate permease
C4K38_RS04180	COG2186	Transcriptional regulator
C4K38_RS04185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4K38_RS04190	COG0733	neurotransmitter:sodium symporter activity
C4K38_RS04200	COG2914	Belongs to the UPF0125 (RnfH) family
C4K38_RS04205	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4K38_RS04215	COG0497	DNA recombination
C4K38_RS04220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4K38_RS04225	COG0443	Heat shock 70 kDa protein
C4K38_RS04230	COG0484	heat shock protein binding
C4K38_RS04235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4K38_RS04240	COG0505	Belongs to the CarA family
C4K38_RS04245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4K38_RS04250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K38_RS04265	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4K38_RS04275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4K38_RS04280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K38_RS04285	COG0149	triose-phosphate isomerase activity
C4K38_RS04290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4K38_RS04310	COG0195	Participates in both transcription termination and antitermination
C4K38_RS04315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4K38_RS04320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4K38_RS04325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4K38_RS04330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4K38_RS04335	COG1185	polyribonucleotide nucleotidyltransferase activity
C4K38_RS04345	COG3408	Glycogen debranching enzyme
C4K38_RS04345	COG3119	arylsulfatase activity
C4K38_RS04355	COG0583	DNA-binding transcription factor activity
C4K38_RS04360	COG2957	Belongs to the agmatine deiminase family
C4K38_RS04410	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K38_RS04425	COG0084	hydrolase, TatD family'
C4K38_RS04430	COG1609	Transcriptional regulator
C4K38_RS04435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K38_RS04435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K38_RS04440	COG1105	Belongs to the carbohydrate kinase PfkB family
C4K38_RS04445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K38_RS04445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K38_RS04445	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4K38_RS04460	COG2814	Major facilitator Superfamily
C4K38_RS04470	COG1309	transcriptional regulator
C4K38_RS04480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4K38_RS04485	COG4774	siderophore transport
C4K38_RS04490	COG3128	pkhd-type hydroxylase
C4K38_RS04500	COG0019	diaminopimelate decarboxylase activity
C4K38_RS04525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4K38_RS04535	COG4608	Belongs to the ABC transporter superfamily
C4K38_RS04540	COG0444	Belongs to the ABC transporter superfamily
C4K38_RS04545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K38_RS04550	COG0601	transmembrane transport
C4K38_RS04555	COG0747	negative chemotaxis
C4K38_RS04565	COG0747	negative chemotaxis
C4K38_RS04570	COG0747	negative chemotaxis
C4K38_RS04595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4K38_RS04600	COG4178	(ABC) transporter
C4K38_RS04620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K38_RS04630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K38_RS04635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K38_RS04640	COG0154	amidase activity
C4K38_RS04645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K38_RS04650	COG1077	Cell shape determining protein MreB Mrl
C4K38_RS04655	COG1792	Involved in formation and maintenance of cell shape
C4K38_RS04665	COG0424	maF-like protein
C4K38_RS04670	COG1530	ribonuclease E activity
C4K38_RS04680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K38_RS04685	COG0312	modulator of DNA gyrase
C4K38_RS04690	COG3028	Belongs to the UPF0307 family
C4K38_RS04695	COG0312	modulator of DNA gyrase
C4K38_RS04730	COG1660	Displays ATPase and GTPase activities
C4K38_RS04745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4K38_RS04750	COG1137	ATPase activity
C4K38_RS04755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4K38_RS04765	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4K38_RS04775	COG1127	ABC transporter
C4K38_RS04780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K38_RS04785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4K38_RS04805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4K38_RS04810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4K38_RS04815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K38_RS04820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K38_RS04825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K38_RS04840	COG0175	sulfate reduction
C4K38_RS04850	COG0204	Acyl-transferase
C4K38_RS04855	COG0280	phosphate acetyltransferase
C4K38_RS04855	COG0857	belongs to the CobB CobQ family
C4K38_RS04870	COG0386	Belongs to the glutathione peroxidase family
C4K38_RS04885	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4K38_RS04895	COG0492	ferredoxin-NADP+ reductase activity
C4K38_RS04910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K38_RS04915	COG0302	gtp cyclohydrolase
C4K38_RS04930	COG0789	Transcriptional regulator
C4K38_RS04940	COG1366	Belongs to the anti-sigma-factor antagonist family
C4K38_RS04950	COG0583	DNA-binding transcription factor activity
C4K38_RS04955	COG1380	Effector of murein hydrolase LrgA
C4K38_RS04960	COG1346	cytolysis
C4K38_RS04970	COG0596	Alpha beta hydrolase
C4K38_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS04995	COG2909	trisaccharide binding
C4K38_RS05005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4K38_RS05010	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K38_RS05030	COG2226	methyltransferase
C4K38_RS05075	COG0814	amino acid
C4K38_RS05080	COG1760	l-serine dehydratase
C4K38_RS05085	COG0583	DNA-binding transcription factor activity
C4K38_RS05095	COG4772	TonB-dependent receptor
C4K38_RS05100	COG3712	iron ion homeostasis
C4K38_RS05105	COG1595	DNA-templated transcription, initiation
C4K38_RS05125	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K38_RS05140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K38_RS05145	COG0583	DNA-binding transcription factor activity
C4K38_RS05165	COG1566	PFAM secretion protein HlyD family protein
C4K38_RS05180	COG0300	oxidoreductase activity
C4K38_RS05210	COG0662	Cupin 2, conserved barrel domain protein
C4K38_RS05210	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4K38_RS05225	COG1696	Membrane protein involved in D-alanine export
C4K38_RS05245	COG3420	alginic acid biosynthetic process
C4K38_RS05255	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4K38_RS05260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS05265	COG1215	transferase activity, transferring glycosyl groups
C4K38_RS05275	COG3022	response to hydroperoxide
C4K38_RS05285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4K38_RS05290	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K38_RS05295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K38_RS05305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS05325	COG0513	Belongs to the DEAD box helicase family
C4K38_RS05335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS05340	COG4597	amino acid ABC transporter
C4K38_RS05345	COG0765	amino acid transport
C4K38_RS05350	COG1126	abc transporter atp-binding protein
C4K38_RS05355	COG2944	sequence-specific DNA binding
C4K38_RS05365	COG2186	Transcriptional regulator
C4K38_RS05370	COG2807	transmembrane transport
C4K38_RS05380	COG2827	Endonuclease containing a URI domain
C4K38_RS05400	COG3081	Nucleoid-associated protein
C4K38_RS05410	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4K38_RS05415	COG0525	valine-tRNA ligase activity
C4K38_RS05430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4K38_RS05435	COG0795	lipopolysaccharide-transporting ATPase activity
C4K38_RS05440	COG0795	lipopolysaccharide-transporting ATPase activity
C4K38_RS05445	COG0481	GTPase activity
C4K38_RS05450	COG0681	Belongs to the peptidase S26 family
C4K38_RS05455	COG0571	ribonuclease III activity
C4K38_RS05460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4K38_RS05465	COG1381	Involved in DNA repair and RecF pathway recombination
C4K38_RS05470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4K38_RS05475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K38_RS05480	COG0047	phosphoribosylformylglycinamidine synthase activity
C4K38_RS05480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4K38_RS05490	COG2190	(PTS) system
C4K38_RS05490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K38_RS05490	COG1263	PTS System
C4K38_RS05495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K38_RS05495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K38_RS05500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K38_RS05505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4K38_RS05510	COG2188	Transcriptional regulator
C4K38_RS05525	COG0494	nUDIX hydrolase
C4K38_RS05545	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4K38_RS05550	COG0477	Major facilitator Superfamily
C4K38_RS05555	COG4536	flavin adenine dinucleotide binding
C4K38_RS05565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4K38_RS05570	COG0228	four-way junction DNA binding
C4K38_RS05575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4K38_RS05580	COG0336	Belongs to the RNA methyltransferase TrmD family
C4K38_RS05585	COG0335	large ribosomal subunit rRNA binding
C4K38_RS05590	COG1607	acyl-coa hydrolase
C4K38_RS05600	COG4974	Belongs to the 'phage' integrase family
C4K38_RS05620	COG2205	protein histidine kinase activity
C4K38_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS05630	COG2197	response regulator
C4K38_RS05650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K38_RS05665	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS05670	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K38_RS05680	COG2311	Membrane
C4K38_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS05705	COG1177	transmembrane transport
C4K38_RS05710	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K38_RS05715	COG3842	ATPase activity
C4K38_RS05720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K38_RS05725	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS05730	COG0583	DNA-binding transcription factor activity
C4K38_RS05740	COG0840	transmembrane signaling receptor activity
C4K38_RS05750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K38_RS05750	COG0457	Tetratricopeptide repeat
C4K38_RS05765	COG2201	protein-glutamate methylesterase activity
C4K38_RS05770	COG2203	Gaf domain
C4K38_RS05770	COG4251	negative regulation of phosphorylation
C4K38_RS05770	COG3706	GGDEF domain
C4K38_RS05770	COG5001	Diguanylate cyclase
C4K38_RS05780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4K38_RS05800	COG1073	alpha beta
C4K38_RS05825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4K38_RS05830	COG0563	adenylate kinase activity
C4K38_RS05835	COG1214	PFAM Peptidase M22, glycoprotease
C4K38_RS05845	COG1801	Protein of unknown function DUF72
C4K38_RS05860	COG0742	ribosomal rna small subunit methyltransferase
C4K38_RS05870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS05890	COG2937	Belongs to the GPAT DAPAT family
C4K38_RS05905	COG2226	methyltransferase
C4K38_RS05910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K38_RS05920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4K38_RS05930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K38_RS05935	COG2171	N-acyltransferase activity
C4K38_RS05940	COG1393	Belongs to the ArsC family
C4K38_RS05945	COG0025	NhaP-type Na H and K H
C4K38_RS05950	COG0436	Aminotransferase
C4K38_RS05955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4K38_RS05960	COG0024	Methionine aminopeptidase
C4K38_RS05965	COG0052	Belongs to the universal ribosomal protein uS2 family
C4K38_RS05970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4K38_RS05975	COG0528	UMP kinase activity
C4K38_RS05980	COG0233	cytoplasmic translational termination
C4K38_RS05985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4K38_RS05995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4K38_RS06015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K38_RS06020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K38_RS06025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K38_RS06030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K38_RS06035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4K38_RS06040	COG0587	DNA-directed DNA polymerase activity
C4K38_RS06045	COG0825	malonyl-CoA metabolic process
C4K38_RS06050	COG0037	tRNA processing
C4K38_RS06055	COG0504	CTP synthase activity
C4K38_RS06060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4K38_RS06065	COG0148	phosphopyruvate hydratase activity
C4K38_RS06075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4K38_RS06085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4K38_RS06090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4K38_RS06095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4K38_RS06100	COG0585	pseudouridine synthase activity
C4K38_RS06105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K38_RS06110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4K38_RS06130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4K38_RS06155	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K38_RS06265	COG4386	tail sheath protein
C4K38_RS06300	COG4381	Mu-like prophage protein gp46
C4K38_RS06350	COG3179	chitinase
C4K38_RS06360	COG1546	Belongs to the CinA family
C4K38_RS06365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4K38_RS06370	COG2137	regulation of response to DNA damage stimulus
C4K38_RS06390	COG3148	PFAM DTW domain containing protein
C4K38_RS06410	COG0583	DNA-binding transcription factor activity
C4K38_RS06430	COG4807	Protein conserved in bacteria
C4K38_RS06435	COG1187	pseudouridine synthase activity
C4K38_RS06445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K38_RS06455	COG3158	transport of potassium into the cell
C4K38_RS06470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4K38_RS06470	COG0392	lysyltransferase activity
C4K38_RS06485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4K38_RS06495	COG0442	prolyl-tRNA aminoacylation
C4K38_RS06520	COG1278	Cold shock
C4K38_RS06525	COG0717	Belongs to the dCTP deaminase family
C4K38_RS06550	COG4215	(ABC) transporter
C4K38_RS06560	COG2366	antibiotic biosynthetic process
C4K38_RS06565	COG0625	glutathione transferase activity
C4K38_RS06575	COG0653	protein targeting
C4K38_RS06585	COG3012	SEC-C Motif Domain Protein
C4K38_RS06620	COG1199	ATP-dependent helicase activity
C4K38_RS06635	COG2885	chlorophyll binding
C4K38_RS06640	COG0259	pyridoxamine-phosphate oxidase activity
C4K38_RS06655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K38_RS06665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4K38_RS06680	COG0583	DNA-binding transcription factor activity
C4K38_RS06695	COG3220	belongs to the UPF0276 family
C4K38_RS06740	COG2084	Dehydrogenase
C4K38_RS06750	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4K38_RS06755	COG2271	Major facilitator Superfamily
C4K38_RS06760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K38_RS06770	COG0306	phosphate transporter
C4K38_RS06780	COG1414	Transcriptional regulator
C4K38_RS06785	COG2814	Major facilitator Superfamily
C4K38_RS06790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K38_RS06795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4K38_RS06800	COG0183	Belongs to the thiolase family
C4K38_RS06805	COG3485	protocatechuate 3,4-dioxygenase
C4K38_RS06810	COG3485	protocatechuate 3,4-dioxygenase
C4K38_RS06815	COG0477	Major facilitator Superfamily
C4K38_RS06825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K38_RS06830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K38_RS06850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS06865	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS06870	COG2814	Major facilitator Superfamily
C4K38_RS06910	COG1473	amidohydrolase
C4K38_RS06920	COG0154	amidase activity
C4K38_RS06945	COG1704	LemA family
C4K38_RS06950	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4K38_RS06965	COG0697	spore germination
C4K38_RS06970	COG0693	protein deglycase activity
C4K38_RS06980	COG1629	transport
C4K38_RS06990	COG1595	DNA-templated transcription, initiation
C4K38_RS06995	COG3422	double-strand break repair
C4K38_RS07000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K38_RS07005	COG0235	Class ii aldolase
C4K38_RS07010	COG1396	sequence-specific DNA binding
C4K38_RS07020	COG1454	alcohol dehydrogenase
C4K38_RS07095	COG3938	Belongs to the proline racemase family
C4K38_RS07100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K38_RS07105	COG0531	amino acid
C4K38_RS07115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4K38_RS07135	COG0583	DNA-binding transcription factor activity
C4K38_RS07140	COG5001	Diguanylate cyclase
C4K38_RS07165	COG3121	Chaperone
C4K38_RS07185	COG2267	carboxylic ester hydrolase activity
C4K38_RS07215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4K38_RS07260	COG0354	folic acid binding
C4K38_RS07265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4K38_RS07295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K38_RS07305	COG0425	Belongs to the sulfur carrier protein TusA family
C4K38_RS07315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4K38_RS07330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K38_RS07335	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4K38_RS07340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K38_RS07345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4K38_RS07365	COG2197	response regulator
C4K38_RS07375	COG3121	Chaperone
C4K38_RS07380	COG3188	usher protein
C4K38_RS07385	COG3121	Chaperone
C4K38_RS07390	COG2831	hemolysin activation secretion protein
C4K38_RS07395	COG3210	domain, Protein
C4K38_RS07425	COG2807	transmembrane transport
C4K38_RS07430	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4K38_RS07440	COG0583	DNA-binding transcription factor activity
C4K38_RS07450	COG2194	sulfuric ester hydrolase activity
C4K38_RS07465	COG3100	YcgL domain-containing protein
C4K38_RS07480	COG2983	Belongs to the UPF0260 family
C4K38_RS07530	COG0121	glutamine amidotransferase
C4K38_RS07540	COG0583	DNA-binding transcription factor activity
C4K38_RS07545	COG2814	Major facilitator Superfamily
C4K38_RS07550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K38_RS07555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K38_RS07560	COG1984	allophanate hydrolase subunit 2
C4K38_RS07570	COG0542	response to heat
C4K38_RS07580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K38_RS07610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4K38_RS07615	COG1643	Atp-dependent helicase
C4K38_RS07625	COG1595	DNA-templated transcription, initiation
C4K38_RS07660	COG0814	amino acid
C4K38_RS07695	COG0477	Major facilitator Superfamily
C4K38_RS07700	COG0583	DNA-binding transcription factor activity
C4K38_RS07710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4K38_RS07715	COG1132	(ABC) transporter
C4K38_RS07725	COG2267	carboxylic ester hydrolase activity
C4K38_RS07740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K38_RS07750	COG0668	transmembrane transport
C4K38_RS07755	COG0513	Belongs to the DEAD box helicase family
C4K38_RS07765	COG3210	domain, Protein
C4K38_RS07825	COG0697	spore germination
C4K38_RS07835	COG0583	DNA-binding transcription factor activity
C4K38_RS07845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K38_RS07850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K38_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS07905	COG5002	protein histidine kinase activity
C4K38_RS07905	COG5001	Diguanylate cyclase
C4K38_RS07915	COG2832	Protein of unknown function (DUF454)
C4K38_RS07940	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4K38_RS07980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4K38_RS07990	COG0642	Histidine kinase
C4K38_RS08000	COG0745	RESPONSE REGULATOR receiver
C4K38_RS08010	COG2350	Protein conserved in bacteria
C4K38_RS08015	COG2917	probably involved in intracellular septation
C4K38_RS08020	COG0613	PHP domain protein
C4K38_RS08025	COG0009	L-threonylcarbamoyladenylate synthase
C4K38_RS08035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4K38_RS08055	COG1113	amino acid transport
C4K38_RS08095	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4K38_RS08110	COG4786	Flagellar basal body rod
C4K38_RS08120	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4K38_RS08125	COG1706	bacterial-type flagellum-dependent cell motility
C4K38_RS08135	COG1256	bacterial-type flagellum assembly
C4K38_RS08145	COG0438	transferase activity, transferring glycosyl groups
C4K38_RS08145	COG1216	Glycosyl transferase, family 2
C4K38_RS08150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K38_RS08160	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C4K38_RS08185	COG1216	Glycosyl transferase, family 2
C4K38_RS08185	COG0438	transferase activity, transferring glycosyl groups
C4K38_RS08190	COG1086	Polysaccharide biosynthesis protein
C4K38_RS08195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K38_RS08200	COG1083	cytidylyl-transferase
C4K38_RS08210	COG2089	acid synthase
C4K38_RS08240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4K38_RS08270	COG1677	Flagellar hook-basal body complex protein FliE
C4K38_RS08305	COG0745	RESPONSE REGULATOR receiver
C4K38_RS08385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4K38_RS08390	COG0643	Histidine kinase
C4K38_RS08390	COG2198	Histidine kinase
C4K38_RS08390	COG0784	Response regulator, receiver
C4K38_RS08395	COG2201	protein-glutamate methylesterase activity
C4K38_RS08400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4K38_RS08410	COG1192	Involved in chromosome partitioning
C4K38_RS08420	COG0835	chemotaxis
C4K38_RS08440	COG4133	protoheme IX ABC transporter activity
C4K38_RS08460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4K38_RS08465	COG1138	Cytochrome C-type biogenesis protein
C4K38_RS08475	COG3088	subunit of a heme lyase
C4K38_RS08495	COG0583	DNA-binding transcription factor activity
C4K38_RS08500	COG2814	Major facilitator Superfamily
C4K38_RS08520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K38_RS08525	COG4413	Urea transporter
C4K38_RS08530	COG0469	pyruvate kinase activity
C4K38_RS08540	COG2084	Dehydrogenase
C4K38_RS08545	COG3622	Belongs to the hyi family
C4K38_RS08550	COG3960	tartronate-semialdehyde synthase activity
C4K38_RS08560	COG1309	transcriptional regulator
C4K38_RS08565	COG2354	Protein conserved in bacteria
C4K38_RS08570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS08585	COG1834	amidinotransferase
C4K38_RS08595	COG2192	nodulation
C4K38_RS08600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K38_RS08620	COG1289	transmembrane transporter activity
C4K38_RS08625	COG2853	Lipoprotein
C4K38_RS08645	COG2113	Glycine betaine
C4K38_RS08650	COG3162	membrane
C4K38_RS08655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K38_RS08665	COG2009	succinate dehydrogenase
C4K38_RS08670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4K38_RS08675	COG1053	succinate dehydrogenase
C4K38_RS08695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K38_RS08700	COG0045	succinate-CoA ligase (ADP-forming) activity
C4K38_RS08740	COG0326	Molecular chaperone. Has ATPase activity
C4K38_RS08750	COG0626	cystathionine gamma-synthase activity
C4K38_RS08760	COG1741	Belongs to the pirin family
C4K38_RS08785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K38_RS08800	COG4771	TonB-dependent receptor
C4K38_RS08805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4K38_RS08815	COG2062	phosphohistidine phosphatase, SixA
C4K38_RS08820	COG1022	Amp-dependent synthetase and ligase
C4K38_RS08840	COG0625	glutathione transferase activity
C4K38_RS08850	COG0628	permease
C4K38_RS08870	COG0284	orotidine-5'-phosphate decarboxylase activity
C4K38_RS08875	COG2130	NADP-dependent
C4K38_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS08885	COG0840	transmembrane signaling receptor activity
C4K38_RS08915	COG2814	Major facilitator Superfamily
C4K38_RS08925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS08925	COG2205	protein histidine kinase activity
C4K38_RS08945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K38_RS08960	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS08970	COG0625	glutathione transferase activity
C4K38_RS08975	COG1131	(ABC) transporter
C4K38_RS08980	COG0842	Transport permease protein
C4K38_RS08995	COG0811	peptide transport
C4K38_RS09000	COG0848	biopolymer transport protein
C4K38_RS09005	COG1663	tetraacyldisaccharide 4'-kinase activity
C4K38_RS09010	COG2835	tetraacyldisaccharide 4'-kinase activity
C4K38_RS09015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K38_RS09020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K38_RS09025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4K38_RS09035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K38_RS09040	COG3608	succinylglutamate desuccinylase aspartoacylase
C4K38_RS09040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4K38_RS09045	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K38_RS09050	COG1530	ribonuclease E activity
C4K38_RS09060	COG0546	phosphoglycolate phosphatase activity
C4K38_RS09065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K38_RS09065	COG0616	signal peptide processing
C4K38_RS09070	COG0424	maF-like protein
C4K38_RS09080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4K38_RS09085	COG0416	fatty acid biosynthetic process
C4K38_RS09100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K38_RS09105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K38_RS09115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4K38_RS09120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4K38_RS09130	COG0084	hydrolase, TatD family'
C4K38_RS09145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K38_RS09160	COG2188	Transcriptional regulator
C4K38_RS09165	COG1397	ADP-ribosylglycohydrolase
C4K38_RS09175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K38_RS09185	COG1418	mRNA catabolic process
C4K38_RS09195	COG1064	alcohol dehydrogenase
C4K38_RS09200	COG2207	Transcriptional regulator
C4K38_RS09230	COG3047	cAMP biosynthetic process
C4K38_RS09230	COG2885	chlorophyll binding
C4K38_RS09235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS09270	COG0183	Belongs to the thiolase family
C4K38_RS09275	COG1024	Enoyl-CoA hydratase
C4K38_RS09275	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS09280	COG0519	Catalyzes the synthesis of GMP from XMP
C4K38_RS09280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K38_RS09285	COG0583	DNA-binding transcription factor activity
C4K38_RS09295	COG0598	Magnesium transport protein CorA
C4K38_RS09300	COG0204	Acyl-transferase
C4K38_RS09345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K38_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS09355	COG0583	DNA-binding transcription factor activity
C4K38_RS09365	COG1953	Uracil, thiamine, allantoin
C4K38_RS09375	COG0560	Phosphoserine phosphatase
C4K38_RS09395	COG4067	protein conserved in archaea
C4K38_RS09395	COG0189	ligase activity
C4K38_RS09400	COG1802	Transcriptional regulator
C4K38_RS09410	COG0372	Belongs to the citrate synthase family
C4K38_RS09430	COG2079	MmgE PrpD family protein
C4K38_RS09435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4K38_RS09450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K38_RS09465	COG0668	transmembrane transport
C4K38_RS09475	COG2885	chlorophyll binding
C4K38_RS09475	COG3047	cAMP biosynthetic process
C4K38_RS09480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K38_RS09485	COG0243	molybdopterin cofactor binding
C4K38_RS09490	COG2146	nitrite reductase [NAD(P)H] activity
C4K38_RS09495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K38_RS09500	COG2815	serine threonine protein kinase
C4K38_RS09500	COG0515	serine threonine protein kinase
C4K38_RS09505	COG2223	nitrite transmembrane transporter activity
C4K38_RS09510	COG3707	response regulator
C4K38_RS09515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS09515	COG1116	anion transmembrane transporter activity
C4K38_RS09520	COG0167	dihydroorotate dehydrogenase activity
C4K38_RS09525	COG3130	regulation of translation
C4K38_RS09535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K38_RS09535	COG0116	Belongs to the methyltransferase superfamily
C4K38_RS09545	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K38_RS09550	COG3171	Protein conserved in bacteria
C4K38_RS09555	COG3135	benzoate transporter
C4K38_RS09560	COG1802	Transcriptional regulator
C4K38_RS09565	COG0402	S-adenosylhomocysteine deaminase activity
C4K38_RS09590	COG1196	nuclear chromosome segregation
C4K38_RS09595	COG3115	cell septum assembly
C4K38_RS09600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K38_RS09625	COG0583	DNA-binding transcription factor activity
C4K38_RS09655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4K38_RS09660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4K38_RS09665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4K38_RS09670	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS09675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K38_RS09680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K38_RS09700	COG2217	Heavy metal translocating P-type atpase
C4K38_RS09710	COG0348	domain, Protein
C4K38_RS09725	COG2010	Cytochrome c
C4K38_RS09740	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K38_RS09745	COG2010	Cytochrome c
C4K38_RS09760	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K38_RS09770	COG0840	transmembrane signaling receptor activity
C4K38_RS09785	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4K38_RS09790	COG0425	Belongs to the sulfur carrier protein TusA family
C4K38_RS09800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K38_RS09810	COG1132	(ABC) transporter
C4K38_RS09815	COG0741	lytic transglycosylase activity
C4K38_RS09820	COG0488	(ABC) transporter
C4K38_RS09825	COG0589	response to stress
C4K38_RS09840	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS09840	COG1024	Enoyl-CoA hydratase
C4K38_RS09845	COG0183	Belongs to the thiolase family
C4K38_RS09895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K38_RS09900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K38_RS09910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4K38_RS09925	COG1477	protein flavinylation
C4K38_RS09930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K38_RS09935	COG0584	glycerophosphoryl diester phosphodiesterase
C4K38_RS09945	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K38_RS09950	COG1136	(ABC) transporter
C4K38_RS09955	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K38_RS09975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K38_RS09975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K38_RS09990	COG2853	Lipoprotein
C4K38_RS10010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4K38_RS10015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K38_RS10020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K38_RS10025	COG0583	DNA-binding transcription factor activity
C4K38_RS10035	COG4251	negative regulation of phosphorylation
C4K38_RS10035	COG2203	Gaf domain
C4K38_RS10035	COG5001	Diguanylate cyclase
C4K38_RS10035	COG3706	GGDEF domain
C4K38_RS10055	COG2233	PERMEase
C4K38_RS10085	COG0556	nucleotide-excision repair
C4K38_RS10090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K38_RS10120	COG0596	Alpha beta hydrolase
C4K38_RS10130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K38_RS10145	COG2214	Heat shock protein DnaJ domain protein
C4K38_RS10150	COG0443	Heat shock 70 kDa protein
C4K38_RS10165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4K38_RS10170	COG0066	3-isopropylmalate dehydratase activity
C4K38_RS10175	COG0473	3-isopropylmalate dehydrogenase activity
C4K38_RS10205	COG0135	phosphoribosylanthranilate isomerase activity
C4K38_RS10210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4K38_RS10215	COG0285	dihydrofolate synthase activity
C4K38_RS10220	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K38_RS10225	COG1286	toxin biosynthetic process
C4K38_RS10260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS10290	COG3397	chitin binding
C4K38_RS10295	COG3469	chitinase activity
C4K38_RS10310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K38_RS10340	COG1879	ABC-type sugar transport system periplasmic component
C4K38_RS10345	COG1129	ABC transporter
C4K38_RS10350	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K38_RS10355	COG1609	Transcriptional regulator
C4K38_RS10360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K38_RS10365	COG1869	D-ribose catabolic process
C4K38_RS10390	COG1278	Cold shock
C4K38_RS10400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K38_RS10405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4K38_RS10410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4K38_RS10415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4K38_RS10420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4K38_RS10425	COG0072	phenylalanine-tRNA ligase activity
C4K38_RS10430	COG0776	regulation of translation
C4K38_RS10805	COG3773	Cell wall hydrolase
C4K38_RS10805	COG3409	Peptidoglycan-binding domain 1 protein
C4K38_RS10820	COG2135	peptidase activity
C4K38_RS10870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K38_RS10905	COG1309	transcriptional regulator
C4K38_RS10910	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS10930	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS10935	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS10940	COG4191	Histidine kinase
C4K38_RS10945	COG4566	intracellular signal transduction
C4K38_RS10955	COG1598	PFAM Uncharacterised protein family UPF0150
C4K38_RS11000	COG0450	alkyl hydroperoxide reductase
C4K38_RS11025	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K38_RS11030	COG3657	addiction module killer protein
C4K38_RS11035	COG5383	Protein conserved in bacteria
C4K38_RS11040	COG3706	GGDEF domain
C4K38_RS11065	COG0531	amino acid
C4K38_RS11075	COG0174	glutamine synthetase
C4K38_RS11090	COG0583	DNA-binding transcription factor activity
C4K38_RS11165	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4K38_RS11170	COG0247	lactate metabolic process
C4K38_RS11175	COG0277	FAD linked oxidase domain protein
C4K38_RS11180	COG0277	FAD linked oxidase domain protein
C4K38_RS11185	COG2186	Transcriptional regulator
C4K38_RS11210	COG1063	alcohol dehydrogenase
C4K38_RS11230	COG0709	Synthesizes selenophosphate from selenide and ATP
C4K38_RS11235	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4K38_RS11240	COG0701	Predicted permease
C4K38_RS11245	COG1414	Transcriptional regulator
C4K38_RS11250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS11255	COG0765	amino acid transport
C4K38_RS11260	COG1126	abc transporter atp-binding protein
C4K38_RS11265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS11275	COG0625	glutathione transferase activity
C4K38_RS11280	COG0384	phenazine biosynthesis protein PhzF
C4K38_RS11300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K38_RS11325	COG0019	diaminopimelate decarboxylase activity
C4K38_RS11340	COG0071	Belongs to the small heat shock protein (HSP20) family
C4K38_RS11345	COG0113	porphobilinogen synthase activity
C4K38_RS11375	COG4172	Belongs to the ABC transporter superfamily
C4K38_RS11380	COG4239	(ABC) transporter, permease
C4K38_RS11385	COG4174	ABC transporter (Permease)
C4K38_RS11390	COG4166	transmembrane transport
C4K38_RS11425	COG4650	regulator
C4K38_RS11435	COG1690	Belongs to the RtcB family
C4K38_RS11445	COG3541	Predicted nucleotidyltransferase
C4K38_RS11450	COG0430	RNA-3'-phosphate cyclase activity
C4K38_RS11475	COG0583	DNA-binding transcription factor activity
C4K38_RS11500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K38_RS11505	COG0583	DNA-binding transcription factor activity
C4K38_RS11510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K38_RS11520	COG3180	Ammonia monooxygenase
C4K38_RS11525	COG0583	DNA-binding transcription factor activity
C4K38_RS11535	COG3609	addiction module antidote protein, CC2985 family
C4K38_RS11540	COG0517	IMP dehydrogenase activity
C4K38_RS11560	COG1177	transmembrane transport
C4K38_RS11565	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K38_RS11570	COG3842	ATPase activity
C4K38_RS11575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K38_RS11580	COG0174	glutamine synthetase
C4K38_RS11585	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS11590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS11595	COG1396	sequence-specific DNA binding
C4K38_RS11595	COG1917	Cupin 2, conserved barrel domain protein
C4K38_RS11645	COG1595	DNA-templated transcription, initiation
C4K38_RS11650	COG3712	iron ion homeostasis
C4K38_RS11655	COG4772	TonB-dependent receptor
C4K38_RS11660	COG0583	DNA-binding transcription factor activity
C4K38_RS11665	COG2814	Major facilitator Superfamily
C4K38_RS11670	COG2384	SAM-dependent methyltransferase
C4K38_RS11675	COG1944	ATP diphosphatase activity
C4K38_RS11720	COG2223	nitrite transmembrane transporter activity
C4K38_RS11735	COG0697	spore germination
C4K38_RS11740	COG0583	DNA-binding transcription factor activity
C4K38_RS11755	COG0697	spore germination
C4K38_RS11760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS11770	COG0659	secondary active sulfate transmembrane transporter activity
C4K38_RS11780	COG1999	signal sequence binding
C4K38_RS11795	COG0583	DNA-binding transcription factor activity
C4K38_RS11800	COG3048	D-serine ammonia-lyase activity
C4K38_RS11805	COG2610	gluconate transmembrane transporter activity
C4K38_RS11810	COG0251	oxidation-reduction process
C4K38_RS11820	COG0688	phosphatidylethanolamine metabolic process
C4K38_RS11835	COG2207	Transcriptional regulator
C4K38_RS11835	COG1917	Cupin 2, conserved barrel domain protein
C4K38_RS11855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K38_RS11885	COG0826	peptidase U32
C4K38_RS11905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS11910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS11920	COG2207	Transcriptional regulator
C4K38_RS11975	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K38_RS11985	COG1611	Belongs to the LOG family
C4K38_RS12000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C4K38_RS12005	COG2204	response regulator
C4K38_RS12010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4K38_RS12020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K38_RS12040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS12045	COG0174	glutamine synthetase
C4K38_RS12060	COG1335	isochorismatase
C4K38_RS12065	COG3224	Antibiotic biosynthesis monooxygenase
C4K38_RS12070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K38_RS12080	COG0417	DNA replication proofreading
C4K38_RS12095	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K38_RS12110	COG0477	Major facilitator Superfamily
C4K38_RS12130	COG4319	ketosteroid isomerase
C4K38_RS12135	COG4335	DNA alkylation repair
C4K38_RS12145	COG0501	Belongs to the peptidase M48B family
C4K38_RS12150	COG1704	LemA family
C4K38_RS12155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K38_RS12200	COG2267	carboxylic ester hydrolase activity
C4K38_RS12215	COG0640	Transcriptional regulator
C4K38_RS12230	COG2308	Evidence 4 Homologs of previously reported genes of
C4K38_RS12240	COG1305	Transglutaminase-like
C4K38_RS12245	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K38_RS12250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4K38_RS12255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K38_RS12265	COG0022	dehydrogenase e1 component
C4K38_RS12270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K38_RS12275	COG1522	sequence-specific DNA binding
C4K38_RS12285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K38_RS12305	COG2372	response to copper ion
C4K38_RS12315	COG1309	transcriptional regulator
C4K38_RS12325	COG0493	'glutamate synthase
C4K38_RS12340	COG1953	Uracil, thiamine, allantoin
C4K38_RS12350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS12355	COG4175	Glycine betaine
C4K38_RS12355	COG0517	IMP dehydrogenase activity
C4K38_RS12365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K38_RS12445	COG1595	DNA-templated transcription, initiation
C4K38_RS12495	COG2391	methyltransferase activity
C4K38_RS12530	COG2204	response regulator
C4K38_RS12545	COG3237	CsbD-like
C4K38_RS12560	COG0745	RESPONSE REGULATOR receiver
C4K38_RS12575	COG3383	formate dehydrogenase (NAD+) activity
C4K38_RS12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K38_RS12585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS12620	COG3718	enzyme involved in inositol metabolism
C4K38_RS12635	COG3962	Belongs to the TPP enzyme family
C4K38_RS12640	COG0673	inositol 2-dehydrogenase activity
C4K38_RS12645	COG1082	Xylose isomerase domain protein TIM barrel
C4K38_RS12650	COG0673	inositol 2-dehydrogenase activity
C4K38_RS12665	COG1129	ABC transporter
C4K38_RS12670	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4K38_RS12680	COG0840	transmembrane signaling receptor activity
C4K38_RS12715	COG4774	siderophore transport
C4K38_RS12730	COG1320	monovalent cation:proton antiporter activity
C4K38_RS12735	COG2212	antiporter activity
C4K38_RS12745	COG0651	ATP synthesis coupled electron transport
C4K38_RS12750	COG1006	Multisubunit Na H antiporter MnhC subunit
C4K38_RS12755	COG2111	Na H antiporter
C4K38_RS12755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4K38_RS12795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K38_RS12800	COG0673	inositol 2-dehydrogenase activity
C4K38_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS12820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K38_RS12825	COG1335	isochorismatase
C4K38_RS12840	COG3383	formate dehydrogenase (NAD+) activity
C4K38_RS12850	COG0814	amino acid
C4K38_RS12880	COG0589	response to stress
C4K38_RS12890	COG0745	RESPONSE REGULATOR receiver
C4K38_RS12895	COG2205	protein histidine kinase activity
C4K38_RS12910	COG3791	Glutathione-dependent formaldehyde-activating
C4K38_RS12925	COG0583	DNA-binding transcription factor activity
C4K38_RS12930	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4K38_RS12935	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS12940	COG2079	MmgE PrpD family protein
C4K38_RS12980	COG0431	NADPH-dependent FMN reductase
C4K38_RS13015	COG1073	alpha beta
C4K38_RS13040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K38_RS13125	COG1522	sequence-specific DNA binding
C4K38_RS13145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS13150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS13160	COG3103	Sh3 type 3 domain protein
C4K38_RS13160	COG0791	NLP P60 protein
C4K38_RS13160	COG1388	LysM domain
C4K38_RS13190	COG0596	Alpha beta hydrolase
C4K38_RS13200	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
C4K38_RS13210	COG3064	Membrane
C4K38_RS13275	COG2080	2 iron, 2 sulfur cluster binding
C4K38_RS13280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4K38_RS13285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K38_RS13290	COG1280	lysine exporter protein (LysE YggA)
C4K38_RS13330	COG1566	PFAM secretion protein HlyD family protein
C4K38_RS13340	COG2828	Protein conserved in bacteria
C4K38_RS13345	COG2207	Transcriptional regulator
C4K38_RS13370	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS13370	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K38_RS13400	COG0833	amino acid
C4K38_RS13405	COG1024	Enoyl-CoA hydratase
C4K38_RS13410	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS13435	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K38_RS13440	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4K38_RS13485	COG2084	Dehydrogenase
C4K38_RS13490	COG3395	kinase activity
C4K38_RS13495	COG0235	Class ii aldolase
C4K38_RS13500	COG2610	gluconate transmembrane transporter activity
C4K38_RS13505	COG3622	Belongs to the hyi family
C4K38_RS13515	COG1349	DNA-binding transcription factor activity
C4K38_RS13595	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS13610	COG2199	diguanylate cyclase activity
C4K38_RS13610	COG2200	EAL domain
C4K38_RS13610	COG2202	Pas domain
C4K38_RS13615	COG0833	amino acid
C4K38_RS13620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS13625	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4K38_RS13640	COG0494	nUDIX hydrolase
C4K38_RS13650	COG3220	belongs to the UPF0276 family
C4K38_RS13660	COG2259	Doxx family
C4K38_RS13670	COG2205	protein histidine kinase activity
C4K38_RS13710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4K38_RS13715	COG1280	lysine exporter protein (LysE YggA)
C4K38_RS13730	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K38_RS13750	COG0754	glutathionylspermidine amidase activity
C4K38_RS13760	COG3766	membrane
C4K38_RS13780	COG1842	Phage shock protein A
C4K38_RS13820	COG0583	DNA-binding transcription factor activity
C4K38_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS13860	COG4172	Belongs to the ABC transporter superfamily
C4K38_RS13865	COG4239	(ABC) transporter, permease
C4K38_RS13870	COG4174	ABC transporter (Permease)
C4K38_RS13875	COG4166	transmembrane transport
C4K38_RS13880	COG4166	transmembrane transport
C4K38_RS13885	COG0741	lytic transglycosylase activity
C4K38_RS13885	COG1388	LysM domain
C4K38_RS13890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K38_RS13900	COG0328	RNA-DNA hybrid ribonuclease activity
C4K38_RS13915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K38_RS13940	COG0431	NADPH-dependent FMN reductase
C4K38_RS13945	COG0640	Transcriptional regulator
C4K38_RS13950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4K38_RS13960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4K38_RS13965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K38_RS13975	COG3139	Protein of unknown function (DUF1315)
C4K38_RS13985	COG0308	aminopeptidase N
C4K38_RS13990	COG0659	secondary active sulfate transmembrane transporter activity
C4K38_RS14010	COG2706	6-phosphogluconolactonase activity
C4K38_RS14040	COG0420	3'-5' exonuclease activity
C4K38_RS14090	COG0714	Associated with various cellular activities
C4K38_RS14100	COG0477	Major facilitator Superfamily
C4K38_RS14105	COG0579	oxidoreductase
C4K38_RS14110	COG2186	Transcriptional regulator
C4K38_RS14140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K38_RS14145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K38_RS14170	COG4795	General secretion pathway protein
C4K38_RS14305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K38_RS14315	COG1247	-acetyltransferase
C4K38_RS14320	COG1794	racemase activity, acting on amino acids and derivatives
C4K38_RS14340	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K38_RS14350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K38_RS14390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS14395	COG1538	Outer membrane efflux protein
C4K38_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS14410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS14415	COG0348	domain, Protein
C4K38_RS14440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K38_RS14455	COG3568	Endonuclease Exonuclease Phosphatase
C4K38_RS14480	COG1640	4-alpha-glucanotransferase
C4K38_RS14485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K38_RS14490	COG0297	glycogen (starch) synthase activity
C4K38_RS14495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K38_RS14525	COG1238	metal cluster binding
C4K38_RS14565	COG0667	Aldo Keto reductase
C4K38_RS14570	COG0583	DNA-binding transcription factor activity
C4K38_RS14585	COG2366	antibiotic biosynthetic process
C4K38_RS14635	COG0583	DNA-binding transcription factor activity
C4K38_RS14650	COG0583	DNA-binding transcription factor activity
C4K38_RS14655	COG2066	Belongs to the glutaminase family
C4K38_RS14665	COG2233	PERMEase
C4K38_RS14675	COG0010	Belongs to the arginase family
C4K38_RS14690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K38_RS14725	COG2194	sulfuric ester hydrolase activity
C4K38_RS14730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4K38_RS14735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4K38_RS14740	COG0561	phosphatase activity
C4K38_RS14745	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K38_RS14750	COG2030	dehydratase
C4K38_RS14750	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS14765	COG3162	membrane
C4K38_RS14770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K38_RS14775	COG2151	metal-sulfur cluster biosynthetic enzyme
C4K38_RS14780	COG3396	Phenylacetate-CoA oxygenase
C4K38_RS14785	COG3460	Phenylacetate-CoA oxygenase
C4K38_RS14790	COG3396	Phenylacetate-CoA oxygenase
C4K38_RS14800	COG0183	Belongs to the thiolase family
C4K38_RS14810	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS14815	COG1024	Enoyl-CoA hydratase
C4K38_RS14820	COG1024	Enoyl-CoA hydratase
C4K38_RS14830	COG3327	negative regulation of DNA-templated transcription, initiation
C4K38_RS14840	COG2204	response regulator
C4K38_RS14885	COG0840	transmembrane signaling receptor activity
C4K38_RS14890	COG1968	undecaprenyl-diphosphatase activity
C4K38_RS14910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K38_RS14925	COG0488	(ABC) transporter
C4K38_RS14945	COG2133	pyrroloquinoline quinone binding
C4K38_RS14955	COG0189	ligase activity
C4K38_RS14960	COG0598	Magnesium transport protein CorA
C4K38_RS14965	COG0024	Methionine aminopeptidase
C4K38_RS14980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K38_RS14985	COG4574	serine-type endopeptidase inhibitor activity
C4K38_RS15050	COG0726	polysaccharide deacetylase
C4K38_RS15060	COG0463	Glycosyl transferase, family 2
C4K38_RS15090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K38_RS15120	COG1070	Carbohydrate kinase
C4K38_RS15140	COG1175	transmembrane transport
C4K38_RS15150	COG4774	siderophore transport
C4K38_RS15155	COG2207	Transcriptional regulator
C4K38_RS15160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K38_RS15170	COG0183	Belongs to the thiolase family
C4K38_RS15175	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS15180	COG1024	Enoyl-CoA hydratase
C4K38_RS15185	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS15190	COG1024	Enoyl-CoA hydratase
C4K38_RS15200	COG0463	Glycosyl transferase, family 2
C4K38_RS15220	COG2814	Major facilitator Superfamily
C4K38_RS15245	COG2076	Multidrug Resistance protein
C4K38_RS15250	COG2076	Multidrug Resistance protein
C4K38_RS15255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K38_RS15260	COG0726	polysaccharide deacetylase
C4K38_RS15265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K38_RS15265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K38_RS15270	COG0463	Glycosyl transferase, family 2
C4K38_RS15275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K38_RS15290	COG1131	(ABC) transporter
C4K38_RS15320	COG0747	negative chemotaxis
C4K38_RS15340	COG0667	Aldo Keto reductase
C4K38_RS15345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K38_RS15350	COG4172	Belongs to the ABC transporter superfamily
C4K38_RS15370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K38_RS15390	COG0477	Major facilitator Superfamily
C4K38_RS15400	COG1132	(ABC) transporter
C4K38_RS15405	COG0583	DNA-binding transcription factor activity
C4K38_RS15410	COG1335	isochorismatase
C4K38_RS15415	COG1335	isochorismatase
C4K38_RS15440	COG0765	amino acid transport
C4K38_RS15490	COG0589	response to stress
C4K38_RS15540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K38_RS15545	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS15565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K38_RS15585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K38_RS15590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K38_RS15615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K38_RS15620	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K38_RS15620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K38_RS15635	COG4608	Belongs to the ABC transporter superfamily
C4K38_RS15640	COG0444	Belongs to the ABC transporter superfamily
C4K38_RS15645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K38_RS15650	COG0601	transmembrane transport
C4K38_RS15655	COG0747	negative chemotaxis
C4K38_RS15660	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4K38_RS15700	COG3121	Chaperone
C4K38_RS15705	COG3539	Fimbrial protein
C4K38_RS15710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS15710	COG2205	protein histidine kinase activity
C4K38_RS15715	COG2197	response regulator
C4K38_RS15720	COG2203	Gaf domain
C4K38_RS15720	COG4251	negative regulation of phosphorylation
C4K38_RS15720	COG5001	Diguanylate cyclase
C4K38_RS15720	COG3706	GGDEF domain
C4K38_RS15730	COG2197	response regulator
C4K38_RS15740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K38_RS15745	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4K38_RS15750	COG1881	PFAM PEBP family protein
C4K38_RS15760	COG3540	Alkaline phosphatase
C4K38_RS15785	COG0811	peptide transport
C4K38_RS15795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K38_RS15810	COG2084	Dehydrogenase
C4K38_RS15820	COG2130	NADP-dependent
C4K38_RS15825	COG1309	transcriptional regulator
C4K38_RS15830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS15835	COG1116	anion transmembrane transporter activity
C4K38_RS15840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K38_RS15845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS15850	COG0235	Class ii aldolase
C4K38_RS15855	COG0583	DNA-binding transcription factor activity
C4K38_RS15865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K38_RS15875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS15885	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS15890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K38_RS15910	COG4206	TonB-dependent receptor
C4K38_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS15935	COG0583	DNA-binding transcription factor activity
C4K38_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS15985	COG1196	nuclear chromosome segregation
C4K38_RS15985	COG3264	Mechanosensitive ion channel
C4K38_RS15990	COG3204	pilus organization
C4K38_RS15995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K38_RS16005	COG0463	Glycosyl transferase, family 2
C4K38_RS16015	COG2203	Gaf domain
C4K38_RS16015	COG4251	negative regulation of phosphorylation
C4K38_RS16015	COG5001	Diguanylate cyclase
C4K38_RS16015	COG3706	GGDEF domain
C4K38_RS16020	COG0583	DNA-binding transcription factor activity
C4K38_RS16025	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS16065	COG0247	lactate metabolic process
C4K38_RS16065	COG0277	FAD linked oxidase domain protein
C4K38_RS16070	COG0583	DNA-binding transcription factor activity
C4K38_RS16085	COG4104	PAAR repeat-containing protein
C4K38_RS16115	COG0494	nUDIX hydrolase
C4K38_RS16125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K38_RS16125	COG2146	nitrite reductase [NAD(P)H] activity
C4K38_RS16130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K38_RS16130	COG2146	nitrite reductase [NAD(P)H] activity
C4K38_RS16135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K38_RS16145	COG1120	ATPase activity
C4K38_RS16150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K38_RS16155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K38_RS16160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K38_RS16165	COG4264	IucA IucC family
C4K38_RS16175	COG4264	IucA IucC family
C4K38_RS16180	COG2814	Major facilitator Superfamily
C4K38_RS16185	COG0019	diaminopimelate decarboxylase activity
C4K38_RS16190	COG4264	IucA IucC family
C4K38_RS16195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K38_RS16200	COG4774	siderophore transport
C4K38_RS16205	COG3712	iron ion homeostasis
C4K38_RS16210	COG1595	DNA-templated transcription, initiation
C4K38_RS16230	COG0174	glutamine synthetase
C4K38_RS16240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS16250	COG2200	EAL domain
C4K38_RS16265	COG3851	Histidine kinase
C4K38_RS16275	COG0784	Response regulator, receiver
C4K38_RS16275	COG2205	protein histidine kinase activity
C4K38_RS16305	COG1522	sequence-specific DNA binding
C4K38_RS16325	COG0473	3-isopropylmalate dehydrogenase activity
C4K38_RS16360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K38_RS16365	COG0601	transmembrane transport
C4K38_RS16370	COG0747	negative chemotaxis
C4K38_RS16375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS16385	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS16415	COG0589	response to stress
C4K38_RS16420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K38_RS16425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS16430	COG1116	anion transmembrane transporter activity
C4K38_RS16445	COG1917	Cupin 2, conserved barrel domain protein
C4K38_RS16445	COG4977	sequence-specific DNA binding
C4K38_RS16480	COG0656	L-ascorbic acid biosynthetic process
C4K38_RS16485	COG0784	Response regulator, receiver
C4K38_RS16485	COG2205	protein histidine kinase activity
C4K38_RS16490	COG3300	MHYT domain
C4K38_RS16490	COG5001	Diguanylate cyclase
C4K38_RS16500	COG2197	response regulator
C4K38_RS16540	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K38_RS16545	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K38_RS16590	COG1113	amino acid transport
C4K38_RS16610	COG0531	amino acid
C4K38_RS16625	COG2909	trisaccharide binding
C4K38_RS16635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K38_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS16660	COG5295	Hep Hag repeat protein
C4K38_RS16665	COG2200	EAL domain
C4K38_RS16665	COG2203	Gaf domain
C4K38_RS16665	COG2199	diguanylate cyclase activity
C4K38_RS16670	COG2205	protein histidine kinase activity
C4K38_RS16670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS16675	COG2197	response regulator
C4K38_RS16685	COG2197	response regulator
C4K38_RS16735	COG0154	amidase activity
C4K38_RS16750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS16765	COG0210	DNA helicase
C4K38_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS16780	COG3321	synthase
C4K38_RS16780	COG0604	alcohol dehydrogenase
C4K38_RS16795	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS16800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4K38_RS16810	COG3469	chitinase activity
C4K38_RS16815	COG3397	chitin binding
C4K38_RS16820	COG0583	DNA-binding transcription factor activity
C4K38_RS16840	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS16860	COG2072	flavoprotein involved in K transport
C4K38_RS16865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS16870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS16875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS16890	COG1566	PFAM secretion protein HlyD family protein
C4K38_RS16915	COG2198	Histidine kinase
C4K38_RS16915	COG2205	protein histidine kinase activity
C4K38_RS16915	COG0784	Response regulator, receiver
C4K38_RS16925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K38_RS16950	COG0672	)-iron permease
C4K38_RS16955	COG2822	iron ion transport
C4K38_RS16970	COG2814	Major facilitator Superfamily
C4K38_RS16980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K38_RS16995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS17010	COG2816	NAD+ diphosphatase activity
C4K38_RS17015	COG1024	Enoyl-CoA hydratase
C4K38_RS17030	COG1335	isochorismatase
C4K38_RS17035	COG2205	protein histidine kinase activity
C4K38_RS17040	COG0745	RESPONSE REGULATOR receiver
C4K38_RS17045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS17085	COG1609	Transcriptional regulator
C4K38_RS17095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K38_RS17160	COG2814	Major facilitator Superfamily
C4K38_RS17165	COG1063	alcohol dehydrogenase
C4K38_RS17185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4K38_RS17185	COG0456	acetyltransferase
C4K38_RS17210	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS17215	COG3384	dioxygenase
C4K38_RS17225	COG2271	Major facilitator Superfamily
C4K38_RS17230	COG3971	2-oxopent-4-enoate hydratase activity
C4K38_RS17240	COG1929	Belongs to the glycerate kinase type-1 family
C4K38_RS17245	COG3835	regulator
C4K38_RS17250	COG2271	Major facilitator Superfamily
C4K38_RS17255	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS17265	COG0583	DNA-binding transcription factor activity
C4K38_RS17270	COG0667	Aldo Keto reductase
C4K38_RS17280	COG1846	Transcriptional regulator
C4K38_RS17290	COG0697	spore germination
C4K38_RS17295	COG0583	DNA-binding transcription factor activity
C4K38_RS17300	COG2200	EAL domain
C4K38_RS17365	COG3258	Cytochrome c
C4K38_RS17370	COG2863	cytochrome
C4K38_RS17390	COG3145	DNA-N1-methyladenine dioxygenase activity
C4K38_RS17395	COG2169	Transcriptional regulator
C4K38_RS17395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K38_RS17405	COG0604	alcohol dehydrogenase
C4K38_RS17425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4K38_RS17430	COG0488	(ABC) transporter
C4K38_RS17440	COG0393	Putative heavy-metal-binding
C4K38_RS17520	COG3121	Chaperone
C4K38_RS17550	COG3093	addiction module antidote protein HigA
C4K38_RS17590	COG3179	chitinase
C4K38_RS17690	COG0616	signal peptide processing
C4K38_RS17745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K38_RS17810	COG0494	nUDIX hydrolase
C4K38_RS17825	COG0583	DNA-binding transcription factor activity
C4K38_RS17830	COG0583	DNA-binding transcription factor activity
C4K38_RS17845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS17855	COG2205	protein histidine kinase activity
C4K38_RS17860	COG0745	RESPONSE REGULATOR receiver
C4K38_RS17870	COG0300	oxidoreductase activity
C4K38_RS17880	COG0583	DNA-binding transcription factor activity
C4K38_RS17885	COG1309	transcriptional regulator
C4K38_RS17910	COG0475	glutathione-regulated potassium exporter activity
C4K38_RS17915	COG1024	Enoyl-CoA hydratase
C4K38_RS17920	COG0515	serine threonine protein kinase
C4K38_RS17920	COG2815	serine threonine protein kinase
C4K38_RS17930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K38_RS17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS17980	COG0789	Transcriptional regulator
C4K38_RS18040	COG2181	nitrate reductase activity
C4K38_RS18045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4K38_RS18050	COG1140	nitrate reductase beta subunit
C4K38_RS18055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C4K38_RS18060	COG2223	nitrite transmembrane transporter activity
C4K38_RS18070	COG3850	Histidine kinase
C4K38_RS18075	COG2197	response regulator
C4K38_RS18085	COG3154	lipid carrier protein
C4K38_RS18090	COG0826	peptidase U32
C4K38_RS18095	COG0826	peptidase U32
C4K38_RS18100	COG0303	'Molybdopterin
C4K38_RS18105	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K38_RS18120	COG3604	Transcriptional regulator
C4K38_RS18125	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C4K38_RS18140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K38_RS18155	COG3256	nitric oxide reductase
C4K38_RS18160	COG2010	Cytochrome c
C4K38_RS18170	COG1845	cytochrome c oxidase, subunit III
C4K38_RS18175	COG0714	Associated with various cellular activities
C4K38_RS18190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K38_RS18195	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K38_RS18220	COG3712	iron ion homeostasis
C4K38_RS18225	COG1595	DNA-templated transcription, initiation
C4K38_RS18265	COG0583	DNA-binding transcription factor activity
C4K38_RS18270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS18280	COG0861	Integral membrane protein TerC family
C4K38_RS18300	COG2814	Major facilitator Superfamily
C4K38_RS18380	COG2207	Transcriptional regulator
C4K38_RS18385	COG1064	alcohol dehydrogenase
C4K38_RS18425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K38_RS18430	COG1136	(ABC) transporter
C4K38_RS18430	COG0577	efflux transmembrane transporter activity
C4K38_RS18435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS18500	COG2197	response regulator
C4K38_RS18505	COG1538	Outer membrane efflux protein
C4K38_RS18525	COG0367	asparagine synthase
C4K38_RS18530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K38_RS18535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K38_RS18540	COG0006	proline dipeptidase activity
C4K38_RS18545	COG2368	4-hydroxyphenylacetate
C4K38_RS18565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS18575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K38_RS18585	COG1136	(ABC) transporter
C4K38_RS18590	COG0515	serine threonine protein kinase
C4K38_RS18590	COG2815	serine threonine protein kinase
C4K38_RS18715	COG0583	DNA-binding transcription factor activity
C4K38_RS18720	COG1335	isochorismatase
C4K38_RS18725	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K38_RS18745	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4K38_RS18815	COG1741	Belongs to the pirin family
C4K38_RS18855	COG1335	isochorismatase
C4K38_RS18865	COG2205	protein histidine kinase activity
C4K38_RS18865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS18875	COG2814	Major facilitator Superfamily
C4K38_RS18910	COG0251	oxidation-reduction process
C4K38_RS18915	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4K38_RS18950	COG1815	bacterial-type flagellum-dependent cell motility
C4K38_RS19030	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS19050	COG0583	DNA-binding transcription factor activity
C4K38_RS19070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS19075	COG2274	protein secretion by the type I secretion system
C4K38_RS19080	COG1538	Outer membrane efflux protein
C4K38_RS19090	COG2197	response regulator
C4K38_RS19105	COG2205	protein histidine kinase activity
C4K38_RS19105	COG0784	Response regulator, receiver
C4K38_RS19110	COG3622	Belongs to the hyi family
C4K38_RS19140	COG3220	belongs to the UPF0276 family
C4K38_RS19155	COG0583	DNA-binding transcription factor activity
C4K38_RS19170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K38_RS19195	COG1294	oxidase, subunit
C4K38_RS19200	COG1271	oxidase subunit
C4K38_RS19205	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K38_RS19245	COG0322	excinuclease ABC activity
C4K38_RS19250	COG2197	response regulator
C4K38_RS19270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K38_RS19275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4K38_RS19280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K38_RS19285	COG4166	transmembrane transport
C4K38_RS19290	COG4174	ABC transporter (Permease)
C4K38_RS19295	COG4239	(ABC) transporter, permease
C4K38_RS19300	COG4172	Belongs to the ABC transporter superfamily
C4K38_RS19305	COG3604	Transcriptional regulator
C4K38_RS19310	COG2610	gluconate transmembrane transporter activity
C4K38_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS19320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K38_RS19330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K38_RS19375	COG1607	acyl-coa hydrolase
C4K38_RS19380	COG0069	glutamate synthase activity
C4K38_RS19385	COG2207	Transcriptional regulator
C4K38_RS19405	COG5001	Diguanylate cyclase
C4K38_RS19415	COG0583	DNA-binding transcription factor activity
C4K38_RS19420	COG3437	response regulator, receiver
C4K38_RS19420	COG2205	protein histidine kinase activity
C4K38_RS19420	COG4999	Histidine kinase
C4K38_RS19420	COG3850	Histidine kinase
C4K38_RS19425	COG1538	Outer membrane efflux protein
C4K38_RS19445	COG2274	protein secretion by the type I secretion system
C4K38_RS19450	COG1253	flavin adenine dinucleotide binding
C4K38_RS19455	COG2390	Transcriptional regulator
C4K38_RS19460	COG0698	ribose 5-phosphate isomerase
C4K38_RS19465	COG1129	ABC transporter
C4K38_RS19470	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K38_RS19475	COG1879	ABC-type sugar transport system periplasmic component
C4K38_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS19485	COG1063	alcohol dehydrogenase
C4K38_RS19490	COG2376	Dihydroxyacetone kinase
C4K38_RS19530	COG0583	DNA-binding transcription factor activity
C4K38_RS19550	COG0789	Transcriptional regulator
C4K38_RS19555	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS19555	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K38_RS19600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4K38_RS19600	COG0316	Belongs to the HesB IscA family
C4K38_RS19635	COG0616	signal peptide processing
C4K38_RS19650	COG4172	Belongs to the ABC transporter superfamily
C4K38_RS19655	COG4239	(ABC) transporter, permease
C4K38_RS19660	COG4174	ABC transporter (Permease)
C4K38_RS19665	COG4166	transmembrane transport
C4K38_RS19670	COG4206	TonB-dependent receptor
C4K38_RS19675	COG4206	TonB-dependent receptor
C4K38_RS19680	COG3712	iron ion homeostasis
C4K38_RS19685	COG1595	DNA-templated transcription, initiation
C4K38_RS19690	COG1024	Enoyl-CoA hydratase
C4K38_RS19690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K38_RS19715	COG3189	MarR family transcriptional regulator
C4K38_RS19720	COG2186	Transcriptional regulator
C4K38_RS19760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K38_RS19790	COG4191	Histidine kinase
C4K38_RS19790	COG0784	Response regulator, receiver
C4K38_RS19815	COG0587	DNA-directed DNA polymerase activity
C4K38_RS19830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K38_RS19845	COG2194	sulfuric ester hydrolase activity
C4K38_RS19850	COG0673	inositol 2-dehydrogenase activity
C4K38_RS19915	COG5002	protein histidine kinase activity
C4K38_RS19915	COG5001	Diguanylate cyclase
C4K38_RS19915	COG3447	MASE1 domain protein
C4K38_RS19925	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS19935	COG0303	'Molybdopterin
C4K38_RS19940	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K38_RS19945	COG0746	molybdenum cofactor guanylyltransferase activity
C4K38_RS19950	COG0583	DNA-binding transcription factor activity
C4K38_RS19965	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K38_RS19970	COG3781	membrane
C4K38_RS19975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K38_RS19985	COG1271	oxidase subunit
C4K38_RS19990	COG1294	oxidase, subunit
C4K38_RS20005	COG0243	molybdopterin cofactor binding
C4K38_RS20015	COG1522	sequence-specific DNA binding
C4K38_RS20070	COG2989	Protein conserved in bacteria
C4K38_RS20085	COG5001	Diguanylate cyclase
C4K38_RS20085	COG3300	MHYT domain
C4K38_RS20095	COG1858	cytochrome C peroxidase
C4K38_RS20120	COG0579	oxidoreductase
C4K38_RS20165	COG2920	part of a sulfur-relay system
C4K38_RS20170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K38_RS20175	COG0435	Glutathione S-transferase
C4K38_RS20180	COG1648	precorrin-2 dehydrogenase activity
C4K38_RS20180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K38_RS20185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4K38_RS20190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4K38_RS20195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4K38_RS20200	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4K38_RS20205	COG1674	ftsk spoiiie
C4K38_RS20210	COG0492	ferredoxin-NADP+ reductase activity
C4K38_RS20215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4K38_RS20220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4K38_RS20225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4K38_RS20230	COG0542	response to heat
C4K38_RS20235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4K38_RS20240	COG1278	Cold shock
C4K38_RS20265	COG0482	sulfurtransferase activity
C4K38_RS20270	COG2915	High frequency lysogenization protein hflD homolog
C4K38_RS20280	COG2850	peptidyl-arginine hydroxylation
C4K38_RS20285	COG2153	protein acetylation
C4K38_RS20300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K38_RS20305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K38_RS20310	COG0649	NAD binding
C4K38_RS20310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K38_RS20325	COG1034	ATP synthesis coupled electron transport
C4K38_RS20330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4K38_RS20335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K38_RS20345	COG0713	ATP synthesis coupled electron transport
C4K38_RS20360	COG1007	ATP synthesis coupled electron transport
C4K38_RS20365	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4K38_RS20385	COG0395	ABC-type sugar transport system, permease component
C4K38_RS20395	COG3842	ATPase activity
C4K38_RS20400	COG3842	ATPase activity
C4K38_RS20405	COG3284	Transcriptional regulator
C4K38_RS20410	COG0215	cysteine-tRNA ligase activity
C4K38_RS20415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K38_RS20425	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K38_RS20430	COG2814	Major facilitator Superfamily
C4K38_RS20435	COG1566	PFAM secretion protein HlyD family protein
C4K38_RS20445	COG1846	Transcriptional regulator
C4K38_RS20450	COG2911	Protein conserved in bacteria
C4K38_RS20455	COG0729	surface antigen
C4K38_RS20465	COG0708	Exodeoxyribonuclease III
C4K38_RS20475	COG2885	chlorophyll binding
C4K38_RS20480	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS20490	COG0789	Transcriptional regulator
C4K38_RS20505	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS20510	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS20520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K38_RS20535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K38_RS20545	COG2866	Carboxypeptidase
C4K38_RS20555	COG2814	Major facilitator Superfamily
C4K38_RS20615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K38_RS20625	COG0217	transcriptional regulatory protein
C4K38_RS20630	COG0583	DNA-binding transcription factor activity
C4K38_RS20635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4K38_RS20640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K38_RS20645	COG3038	cytochrome b561
C4K38_RS20655	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS20655	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K38_RS20685	COG2814	Major facilitator Superfamily
C4K38_RS20690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K38_RS20700	COG0776	regulation of translation
C4K38_RS20705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K38_RS20710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4K38_RS20715	COG0740	serine-type endopeptidase activity
C4K38_RS20720	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4K38_RS20740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4K38_RS20745	COG1686	Belongs to the peptidase S11 family
C4K38_RS20755	COG1253	flavin adenine dinucleotide binding
C4K38_RS20765	COG0583	DNA-binding transcription factor activity
C4K38_RS20775	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4K38_RS20785	COG3132	Protein of unknown function, DUF480
C4K38_RS20795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K38_RS20815	COG0826	peptidase U32
C4K38_RS20820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS20825	COG4215	(ABC) transporter
C4K38_RS20845	COG1737	Transcriptional regulator
C4K38_RS20855	COG2056	Na+-H+ antiporter family
C4K38_RS20860	COG0840	transmembrane signaling receptor activity
C4K38_RS20890	COG0720	synthase
C4K38_RS20895	COG0596	Alpha beta hydrolase
C4K38_RS20905	COG1051	belongs to the nudix hydrolase family
C4K38_RS20910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K38_RS20915	COG0402	S-adenosylhomocysteine deaminase activity
C4K38_RS20920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K38_RS20925	COG2207	Transcriptional regulator
C4K38_RS20940	COG0583	DNA-binding transcription factor activity
C4K38_RS20945	COG0583	DNA-binding transcription factor activity
C4K38_RS20955	COG1522	sequence-specific DNA binding
C4K38_RS20965	COG2223	nitrite transmembrane transporter activity
C4K38_RS20970	COG4772	TonB-dependent receptor
C4K38_RS20980	COG1595	DNA-templated transcription, initiation
C4K38_RS20985	COG1335	isochorismatase
C4K38_RS21020	COG1294	oxidase, subunit
C4K38_RS21025	COG1271	oxidase subunit
C4K38_RS21030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K38_RS21060	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K38_RS21070	COG2197	response regulator
C4K38_RS21075	COG0784	Response regulator, receiver
C4K38_RS21075	COG2205	protein histidine kinase activity
C4K38_RS21080	COG2205	protein histidine kinase activity
C4K38_RS21080	COG0784	Response regulator, receiver
C4K38_RS21095	COG3121	Chaperone
C4K38_RS21140	COG2274	protein secretion by the type I secretion system
C4K38_RS21145	COG1538	Outer membrane efflux protein
C4K38_RS21150	COG2080	2 iron, 2 sulfur cluster binding
C4K38_RS21155	COG2010	Cytochrome c
C4K38_RS21155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K38_RS21160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K38_RS21160	COG2010	Cytochrome c
C4K38_RS21180	COG0840	transmembrane signaling receptor activity
C4K38_RS21185	COG4774	siderophore transport
C4K38_RS21195	COG0300	oxidoreductase activity
C4K38_RS21200	COG1864	DNA RNA non-specific endonuclease
C4K38_RS21200	COG3591	Belongs to the peptidase S1B family
C4K38_RS21220	COG4106	trans-aconitate 2-methyltransferase activity
C4K38_RS21235	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS21240	COG1942	4-Oxalocrotonate Tautomerase
C4K38_RS21250	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4K38_RS21260	COG3135	benzoate transporter
C4K38_RS21265	COG2814	Major facilitator Superfamily
C4K38_RS21295	COG3485	protocatechuate 3,4-dioxygenase
C4K38_RS21300	COG4829	muconolactone delta-isomerase
C4K38_RS21305	COG4948	Mandelate Racemase Muconate Lactonizing
C4K38_RS21410	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4K38_RS21430	COG2814	Major facilitator Superfamily
C4K38_RS21470	COG0154	amidase activity
C4K38_RS21485	COG0583	DNA-binding transcription factor activity
C4K38_RS21495	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS21505	COG1335	isochorismatase
C4K38_RS21530	COG3012	SEC-C Motif Domain Protein
C4K38_RS21530	COG3318	Belongs to the UPF0149 family
C4K38_RS21545	COG0730	response to heat
C4K38_RS21575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K38_RS21585	COG1335	isochorismatase
C4K38_RS21590	COG1335	isochorismatase
C4K38_RS21600	COG0583	DNA-binding transcription factor activity
C4K38_RS21615	COG0656	L-ascorbic acid biosynthetic process
C4K38_RS21635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4K38_RS21650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS21655	COG0577	efflux transmembrane transporter activity
C4K38_RS21655	COG1136	(ABC) transporter
C4K38_RS21730	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4K38_RS21740	COG1309	transcriptional regulator
C4K38_RS21750	COG0596	Alpha beta hydrolase
C4K38_RS21790	COG4977	sequence-specific DNA binding
C4K38_RS21855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K38_RS21865	COG0840	transmembrane signaling receptor activity
C4K38_RS21870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4K38_RS21875	COG1690	Belongs to the RtcB family
C4K38_RS21905	COG1132	(ABC) transporter
C4K38_RS21955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K38_RS22015	COG2207	Transcriptional regulator
C4K38_RS22085	COG2197	response regulator
C4K38_RS22090	COG2205	protein histidine kinase activity
C4K38_RS22090	COG3437	response regulator, receiver
C4K38_RS22090	COG3850	Histidine kinase
C4K38_RS22090	COG4999	Histidine kinase
C4K38_RS22145	COG0741	lytic transglycosylase activity
C4K38_RS22185	COG0477	Major facilitator Superfamily
C4K38_RS22190	COG0583	DNA-binding transcription factor activity
C4K38_RS22195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K38_RS22200	COG0235	Class ii aldolase
C4K38_RS22205	COG0477	Major facilitator Superfamily
C4K38_RS22210	COG0583	DNA-binding transcription factor activity
C4K38_RS22215	COG0768	penicillin binding
C4K38_RS22250	COG5006	permease, DMT superfamily
C4K38_RS22260	COG1309	transcriptional regulator
C4K38_RS22265	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS22290	COG0431	NADPH-dependent FMN reductase
C4K38_RS22295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS22305	COG3829	transcription factor binding
C4K38_RS22325	COG2011	ABC-type metal ion transport system permease component
C4K38_RS22365	COG1121	(ABC) transporter
C4K38_RS22370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K38_RS22380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K38_RS22395	COG0642	Histidine kinase
C4K38_RS22405	COG4232	protein-disulfide reductase activity
C4K38_RS22410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4K38_RS22430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K38_RS22465	COG1309	transcriptional regulator
C4K38_RS22480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K38_RS22485	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS22490	COG1024	Enoyl-CoA hydratase
C4K38_RS22505	COG3123	guanosine phosphorylase activity
C4K38_RS22510	COG3217	Mosc domain protein beta barrel domain protein
C4K38_RS22510	COG0633	Ferredoxin
C4K38_RS22525	COG3851	Histidine kinase
C4K38_RS22530	COG2197	response regulator
C4K38_RS22535	COG1597	lipid kinase activity
C4K38_RS22550	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K38_RS22555	COG0746	molybdenum cofactor guanylyltransferase activity
C4K38_RS22565	COG0564	pseudouridine synthase activity
C4K38_RS22590	COG0004	ammonium transporteR
C4K38_RS22610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K38_RS22630	COG2197	response regulator
C4K38_RS22635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS22635	COG2205	protein histidine kinase activity
C4K38_RS22640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4K38_RS22645	COG1956	GAF domain-containing protein
C4K38_RS22655	COG5002	protein histidine kinase activity
C4K38_RS22655	COG0784	Response regulator, receiver
C4K38_RS22655	COG2205	protein histidine kinase activity
C4K38_RS22660	COG1846	Transcriptional regulator
C4K38_RS22665	COG0386	Belongs to the glutathione peroxidase family
C4K38_RS22670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K38_RS22675	COG0436	Aminotransferase
C4K38_RS22680	COG0501	Belongs to the peptidase M48B family
C4K38_RS22685	COG0500	methyltransferase
C4K38_RS22690	COG3384	dioxygenase
C4K38_RS22705	COG1024	Enoyl-CoA hydratase
C4K38_RS22715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4K38_RS22720	COG3214	Protein conserved in bacteria
C4K38_RS22730	COG0583	DNA-binding transcription factor activity
C4K38_RS22740	COG0583	DNA-binding transcription factor activity
C4K38_RS22745	COG1846	Transcriptional regulator
C4K38_RS22750	COG1764	response to oxidative stress
C4K38_RS22760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4K38_RS22775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K38_RS22795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K38_RS22825	COG1376	ErfK ybiS ycfS ynhG family protein
C4K38_RS22840	COG4181	ATPase activity
C4K38_RS22845	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4K38_RS22850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K38_RS22865	COG2197	response regulator
C4K38_RS22875	COG2259	Doxx family
C4K38_RS22880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K38_RS22885	COG0084	hydrolase, TatD family'
C4K38_RS22920	COG0745	RESPONSE REGULATOR receiver
C4K38_RS22925	COG2205	protein histidine kinase activity
C4K38_RS22930	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4K38_RS22940	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4K38_RS22975	COG4221	oxidoreductase activity
C4K38_RS22980	COG1555	photosystem II stabilization
C4K38_RS22980	COG1596	polysaccharide export
C4K38_RS22985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K38_RS22995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K38_RS23000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K38_RS23015	COG1063	alcohol dehydrogenase
C4K38_RS23030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K38_RS23045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4K38_RS23050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4K38_RS23060	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4K38_RS23080	COG0776	regulation of translation
C4K38_RS23105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4K38_RS23110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4K38_RS23115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K38_RS23125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4K38_RS23140	COG0402	S-adenosylhomocysteine deaminase activity
C4K38_RS23145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K38_RS23150	COG0546	phosphoglycolate phosphatase activity
C4K38_RS23155	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS23170	COG5001	Diguanylate cyclase
C4K38_RS23170	COG5002	protein histidine kinase activity
C4K38_RS23180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C4K38_RS23185	COG1054	Belongs to the UPF0176 family
C4K38_RS23190	COG0271	Belongs to the BolA IbaG family
C4K38_RS23200	COG0114	fumarate hydratase activity
C4K38_RS23205	COG0697	spore germination
C4K38_RS23210	COG0183	Belongs to the thiolase family
C4K38_RS23215	COG2326	polyphosphate kinase activity
C4K38_RS23220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4K38_RS23220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS23225	COG0367	asparagine synthase
C4K38_RS23230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K38_RS23230	COG0189	ligase activity
C4K38_RS23235	COG1363	Peptidase, m42
C4K38_RS23240	COG3089	Belongs to the UPF0270 family
C4K38_RS23245	COG1742	UPF0060 membrane protein
C4K38_RS23255	COG1368	sulfuric ester hydrolase activity
C4K38_RS23275	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS23285	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C4K38_RS23290	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4K38_RS23295	COG0235	Class ii aldolase
C4K38_RS23305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4K38_RS23310	COG1073	alpha beta
C4K38_RS23335	COG2840	Smr protein MutS2
C4K38_RS23340	COG0302	gtp cyclohydrolase
C4K38_RS23350	COG0625	glutathione transferase activity
C4K38_RS23355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS23365	COG2252	PERMEase
C4K38_RS23390	COG4266	Belongs to the allantoicase family
C4K38_RS23395	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4K38_RS23405	COG2233	PERMEase
C4K38_RS23435	COG1560	Kdo2-lipid A biosynthetic process
C4K38_RS23440	COG0850	regulation of cytokinetic process
C4K38_RS23445	COG2894	cell division
C4K38_RS23450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4K38_RS23455	COG0564	pseudouridine synthase activity
C4K38_RS23465	COG1362	aminopeptidase activity
C4K38_RS23470	COG0668	transmembrane transport
C4K38_RS23475	COG1473	amidohydrolase
C4K38_RS23505	COG3842	ATPase activity
C4K38_RS23515	COG0604	alcohol dehydrogenase
C4K38_RS23515	COG3321	synthase
C4K38_RS23515	COG4221	oxidoreductase activity
C4K38_RS23515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K38_RS23525	COG2200	EAL domain
C4K38_RS23550	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K38_RS23555	COG2010	Cytochrome c
C4K38_RS23585	COG2974	May be involved in recombination
C4K38_RS23590	COG0385	Bile acid
C4K38_RS23595	COG2076	Multidrug Resistance protein
C4K38_RS23625	COG2202	Pas domain
C4K38_RS23625	COG2205	protein histidine kinase activity
C4K38_RS23675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4K38_RS23680	COG0406	alpha-ribazole phosphatase activity
C4K38_RS23685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4K38_RS23695	COG1492	cobalamin metabolic process
C4K38_RS23710	COG0778	Nitroreductase
C4K38_RS23715	COG1797	cobyrinic acid a,c-diamide synthase activity
C4K38_RS23740	COG0791	NLP P60 protein
C4K38_RS23745	COG0791	NLP P60 protein
C4K38_RS23750	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K38_RS23755	COG0628	permease
C4K38_RS23765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4K38_RS23770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4K38_RS23785	COG3122	Protein conserved in bacteria
C4K38_RS23790	COG3956	TIGRFAM MazG family protein
C4K38_RS23795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K38_RS23800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K38_RS23820	COG0784	Response regulator, receiver
C4K38_RS23820	COG2205	protein histidine kinase activity
C4K38_RS23820	COG5002	protein histidine kinase activity
C4K38_RS23825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K38_RS23845	COG1393	Belongs to the ArsC family
C4K38_RS23860	COG2818	Glycosylase
C4K38_RS23865	COG0037	tRNA processing
C4K38_RS23875	COG3091	SprT-like family
C4K38_RS23880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K38_RS23920	COG2205	protein histidine kinase activity
C4K38_RS23925	COG0745	RESPONSE REGULATOR receiver
C4K38_RS23930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K38_RS23930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K38_RS23945	COG1558	bacterial-type flagellum-dependent cell motility
C4K38_RS23950	COG1815	bacterial-type flagellum-dependent cell motility
C4K38_RS23955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K38_RS23960	COG0835	chemotaxis
C4K38_RS23960	COG0784	Response regulator, receiver
C4K38_RS23980	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4K38_RS23985	COG0477	Major facilitator Superfamily
C4K38_RS23995	COG2205	protein histidine kinase activity
C4K38_RS24025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K38_RS24055	COG2239	Acts as a magnesium transporter
C4K38_RS24075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K38_RS24080	COG0527	aspartate kinase activity
C4K38_RS24085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K38_RS24090	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4K38_RS24095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K38_RS24100	COG2988	succinylglutamate desuccinylase activity
C4K38_RS24110	COG3724	N-succinylarginine dihydrolase activity
C4K38_RS24115	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS24130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K38_RS24160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS24165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K38_RS24175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K38_RS24210	COG0563	adenylate kinase activity
C4K38_RS24225	COG3706	GGDEF domain
C4K38_RS24245	COG0504	CTP synthase activity
C4K38_RS24250	COG2329	Antibiotic biosynthesis monooxygenase
C4K38_RS24260	COG0584	glycerophosphoryl diester phosphodiesterase
C4K38_RS24290	COG0306	phosphate transporter
C4K38_RS24300	COG1984	allophanate hydrolase subunit 2
C4K38_RS24310	COG0439	Biotin carboxylase
C4K38_RS24320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K38_RS24335	COG3008	intermembrane lipid transfer
C4K38_RS24340	COG2995	paraquat-inducible protein a
C4K38_RS24345	COG2995	paraquat-inducible protein a
C4K38_RS24360	COG0583	DNA-binding transcription factor activity
C4K38_RS24375	COG3795	YCII-related domain
C4K38_RS24410	COG0436	Aminotransferase
C4K38_RS24420	COG3265	gluconokinase activity
C4K38_RS24425	COG1609	Transcriptional regulator
C4K38_RS24440	COG0583	DNA-binding transcription factor activity
C4K38_RS24455	COG2271	Major facilitator Superfamily
C4K38_RS24465	COG0583	DNA-binding transcription factor activity
C4K38_RS24475	COG2986	histidine ammonia-lyase
C4K38_RS24485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS24500	COG3712	iron ion homeostasis
C4K38_RS24505	COG1595	DNA-templated transcription, initiation
C4K38_RS24530	COG0242	peptide deformylase activity
C4K38_RS24535	COG1295	ribonuclease BN
C4K38_RS24545	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS24550	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS24555	COG2267	carboxylic ester hydrolase activity
C4K38_RS24560	COG2030	dehydratase
C4K38_RS24585	COG3530	Putative quorum-sensing-regulated virulence factor
C4K38_RS24590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K38_RS24595	COG0800	Aldolase
C4K38_RS24610	COG1737	Transcriptional regulator
C4K38_RS24615	COG0676	glucose-6-phosphate 1-epimerase activity
C4K38_RS24625	COG3842	ATPase activity
C4K38_RS24630	COG0395	ABC-type sugar transport system, permease component
C4K38_RS24635	COG1175	transmembrane transport
C4K38_RS24640	COG1653	transport
C4K38_RS24675	COG1803	Methylglyoxal synthase
C4K38_RS24685	COG3712	iron ion homeostasis
C4K38_RS24690	COG4771	TonB-dependent receptor
C4K38_RS24700	COG2832	Protein of unknown function (DUF454)
C4K38_RS24705	COG0840	transmembrane signaling receptor activity
C4K38_RS24710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K38_RS24735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K38_RS24760	COG0509	glycine decarboxylation via glycine cleavage system
C4K38_RS24765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K38_RS24765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K38_RS24770	COG1760	l-serine dehydratase
C4K38_RS24780	COG1278	Cold shock
C4K38_RS24790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4K38_RS24795	COG4964	Belongs to the GSP D family
C4K38_RS24880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K38_RS24885	COG0602	queuosine metabolic process
C4K38_RS24890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4K38_RS24895	COG2885	chlorophyll binding
C4K38_RS24900	COG0823	Involved in the tonB-independent uptake of proteins
C4K38_RS24920	COG0824	Thioesterase
C4K38_RS24925	COG2255	four-way junction helicase activity
C4K38_RS24930	COG0632	four-way junction helicase activity
C4K38_RS24935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4K38_RS24940	COG0217	transcriptional regulatory protein
C4K38_RS24945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4K38_RS24955	COG0783	Belongs to the Dps family
C4K38_RS24965	COG2900	Belongs to the SlyX family
C4K38_RS24985	COG0668	transmembrane transport
C4K38_RS24990	COG1666	GTP binding
C4K38_RS25000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS25000	COG4191	Histidine kinase
C4K38_RS25005	COG2096	Adenosyltransferase
C4K38_RS25020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4K38_RS25025	COG0653	protein targeting
C4K38_RS25035	COG0433	COG0433 Predicted ATPase
C4K38_RS25045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K38_RS25045	COG0438	transferase activity, transferring glycosyl groups
C4K38_RS25070	COG2925	Exonuclease
C4K38_RS25095	COG0714	Associated with various cellular activities
C4K38_RS25115	COG0469	pyruvate kinase activity
C4K38_RS25120	COG1024	Enoyl-CoA hydratase
C4K38_RS25130	COG3706	GGDEF domain
C4K38_RS25145	COG4191	Histidine kinase
C4K38_RS25155	COG0477	Major facilitator Superfamily
C4K38_RS25185	COG2207	Transcriptional regulator
C4K38_RS25190	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS25200	COG0583	DNA-binding transcription factor activity
C4K38_RS25205	COG2910	NAD(P)H-binding
C4K38_RS25215	COG0583	DNA-binding transcription factor activity
C4K38_RS25230	COG0477	Major facilitator Superfamily
C4K38_RS25245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K38_RS25250	COG0583	DNA-binding transcription factor activity
C4K38_RS25265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4K38_RS25295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS25300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS25310	COG3642	lipopolysaccharide core region biosynthetic process
C4K38_RS25320	COG0642	Histidine kinase
C4K38_RS25335	COG0459	protein refolding
C4K38_RS25340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4K38_RS25350	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4K38_RS25360	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS25365	COG0489	protein tyrosine kinase activity
C4K38_RS25370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K38_RS25370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K38_RS25375	COG4657	Part of a membrane complex involved in electron transport
C4K38_RS25380	COG2878	Part of a membrane complex involved in electron transport
C4K38_RS25385	COG4658	electron transport chain
C4K38_RS25390	COG4659	FMN binding
C4K38_RS25395	COG4660	Part of a membrane complex involved in electron transport
C4K38_RS25400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4K38_RS25410	COG2197	response regulator
C4K38_RS25415	COG0137	argininosuccinate synthase activity
C4K38_RS25425	COG0418	dihydroorotase activity
C4K38_RS25430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K38_RS25435	COG0450	alkyl hydroperoxide reductase
C4K38_RS25450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4K38_RS25455	COG3383	formate dehydrogenase (NAD+) activity
C4K38_RS25465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K38_RS25470	COG3842	ATPase activity
C4K38_RS25475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4K38_RS25485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4K38_RS25505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS25510	COG0765	amino acid transport
C4K38_RS25515	COG0765	amino acid transport
C4K38_RS25520	COG1126	abc transporter atp-binding protein
C4K38_RS25550	COG2076	Multidrug Resistance protein
C4K38_RS25570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K38_RS25585	COG4191	Histidine kinase
C4K38_RS25595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K38_RS25600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4K38_RS25605	COG0583	DNA-binding transcription factor activity
C4K38_RS25615	COG1280	lysine exporter protein (LysE YggA)
C4K38_RS25630	COG0254	rRNA binding
C4K38_RS25635	COG2197	response regulator
C4K38_RS25640	COG0069	glutamate synthase activity
C4K38_RS25665	COG2246	polysaccharide biosynthetic process
C4K38_RS25680	COG1113	amino acid transport
C4K38_RS25690	COG1695	Transcriptional regulator
C4K38_RS25695	COG2375	cellular response to nickel ion
C4K38_RS25705	COG4628	conserved protein (DUF2132)
C4K38_RS25710	COG4206	TonB-dependent receptor
C4K38_RS25745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K38_RS25760	COG2226	methyltransferase
C4K38_RS25765	COG0500	methyltransferase
C4K38_RS25770	COG0590	tRNA wobble adenosine to inosine editing
C4K38_RS25785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K38_RS25785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K38_RS25795	COG0366	Alpha amylase catalytic
C4K38_RS25800	COG1263	PTS System
C4K38_RS25800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K38_RS25805	COG2188	Transcriptional regulator
C4K38_RS25820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K38_RS25820	COG0519	Catalyzes the synthesis of GMP from XMP
C4K38_RS25845	COG1570	exodeoxyribonuclease VII activity
C4K38_RS25850	COG0739	heme binding
C4K38_RS25855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K38_RS25865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K38_RS25870	COG0436	Aminotransferase
C4K38_RS25875	COG1160	GTP binding
C4K38_RS25890	COG0124	histidyl-tRNA synthetase
C4K38_RS25895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4K38_RS25900	COG1426	Protein conserved in bacteria
C4K38_RS25910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4K38_RS25915	COG0105	UTP biosynthetic process
C4K38_RS25925	COG0633	Ferredoxin
C4K38_RS25930	COG0443	Heat shock 70 kDa protein
C4K38_RS25935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K38_RS25950	COG1104	cysteine desulfurase activity
C4K38_RS25960	COG1045	serine acetyltransferase
C4K38_RS25975	COG3134	Outer membrane lipoprotein
C4K38_RS25990	COG1862	Preprotein translocase
C4K38_RS25995	COG0343	queuine tRNA-ribosyltransferase activity
C4K38_RS26000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4K38_RS26025	COG2853	Lipoprotein
C4K38_RS26070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K38_RS26120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K38_RS26135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K38_RS26135	COG5322	oxidoreductase activity
C4K38_RS26145	COG2771	luxR family
C4K38_RS26170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K38_RS26185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K38_RS26190	COG0109	protoheme IX farnesyltransferase activity
C4K38_RS26200	COG1845	cytochrome c oxidase, subunit III
C4K38_RS26205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K38_RS26210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K38_RS26220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K38_RS26230	COG1017	nitric oxide dioxygenase activity
C4K38_RS26230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K38_RS26270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K38_RS26280	COG5002	protein histidine kinase activity
C4K38_RS26295	COG3706	GGDEF domain
C4K38_RS26295	COG4251	negative regulation of phosphorylation
C4K38_RS26295	COG2203	Gaf domain
C4K38_RS26295	COG5001	Diguanylate cyclase
C4K38_RS26300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4K38_RS26305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4K38_RS26320	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K38_RS26325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K38_RS26330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K38_RS26335	COG0772	Belongs to the SEDS family
C4K38_RS26340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4K38_RS26345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K38_RS26350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4K38_RS26355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K38_RS26370	COG0275	rRNA processing
C4K38_RS26375	COG2001	Belongs to the MraZ family
C4K38_RS26390	COG3107	peptidoglycan biosynthetic process
C4K38_RS26395	COG0792	nuclease activity
C4K38_RS26400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4K38_RS26405	COG2823	Periplasmic or secreted lipoprotein
C4K38_RS26410	COG2969	positive regulation of protein catabolic process
C4K38_RS26415	COG0625	glutathione transferase activity
C4K38_RS26420	COG2857	Cytochrome c1
C4K38_RS26425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4K38_RS26430	COG0723	plastoquinol--plastocyanin reductase activity
C4K38_RS26435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4K38_RS26440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4K38_RS26445	COG0667	Aldo Keto reductase
C4K38_RS26450	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS26460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K38_RS26465	COG0180	Tryptophanyl-tRNA synthetase
C4K38_RS26485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K38_RS26490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K38_RS26510	COG0642	Histidine kinase
C4K38_RS26515	COG2909	trisaccharide binding
C4K38_RS26530	COG0318	PFAM AMP-dependent synthetase and ligase
C4K38_RS26550	COG1280	lysine exporter protein (LysE YggA)
C4K38_RS26555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K38_RS26560	COG2813	Specifically methylates the guanine in position
C4K38_RS26565	COG2119	membrane
C4K38_RS26570	COG0501	Belongs to the peptidase M48B family
C4K38_RS26575	COG0840	transmembrane signaling receptor activity
C4K38_RS26580	COG2135	peptidase activity
C4K38_RS26640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4K38_RS26645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4K38_RS26655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4K38_RS26660	COG1090	epimerase
C4K38_RS26665	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4K38_RS26685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4K38_RS26690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4K38_RS26700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4K38_RS26705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4K38_RS26715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4K38_RS26720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4K38_RS26730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4K38_RS26735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4K38_RS26740	COG0193	aminoacyl-tRNA hydrolase activity
C4K38_RS26755	COG2197	response regulator
C4K38_RS26760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS26760	COG2205	protein histidine kinase activity
C4K38_RS26765	COG3397	chitin binding
C4K38_RS26830	COG2258	MOSC domain
C4K38_RS26855	COG2223	nitrite transmembrane transporter activity
C4K38_RS26910	COG0367	asparagine synthase
C4K38_RS26915	COG0405	Gamma-glutamyltransferase
C4K38_RS26930	COG4680	protein conserved in bacteria
C4K38_RS26945	COG0789	Transcriptional regulator
C4K38_RS26965	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K38_RS26980	COG3655	Transcriptional regulator
C4K38_RS27000	COG0662	Cupin 2, conserved barrel domain protein
C4K38_RS27010	COG0583	DNA-binding transcription factor activity
C4K38_RS27015	COG0583	DNA-binding transcription factor activity
C4K38_RS27025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K38_RS27030	COG1028	Short-chain dehydrogenase reductase Sdr
C4K38_RS27035	COG0583	DNA-binding transcription factor activity
C4K38_RS27095	COG0477	Major facilitator Superfamily
C4K38_RS27100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K38_RS27115	COG2031	fatty acid transporter
C4K38_RS27130	COG0288	reversible hydration of carbon dioxide
C4K38_RS27140	COG0456	acetyltransferase
C4K38_RS27165	COG3008	intermembrane lipid transfer
C4K38_RS27170	COG2995	paraquat-inducible protein a
C4K38_RS27175	COG2995	paraquat-inducible protein a
C4K38_RS27210	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4K38_RS27215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4K38_RS27220	COG1183	phosphatidylcholine synthase activity
C4K38_RS27225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4K38_RS27235	COG0028	Belongs to the TPP enzyme family
C4K38_RS27255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K38_RS27285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4K38_RS27290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K38_RS27295	COG4558	Periplasmic binding protein
C4K38_RS27305	COG1489	DNA binding
C4K38_RS27310	COG0436	Aminotransferase
C4K38_RS27320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K38_RS27330	COG4191	Histidine kinase
C4K38_RS27355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K38_RS27360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4K38_RS27370	COG0166	Belongs to the GPI family
C4K38_RS27375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K38_RS27390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K38_RS27400	COG2823	Periplasmic or secreted lipoprotein
C4K38_RS27415	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4K38_RS27420	COG0237	dephospho-CoA kinase activity
C4K38_RS27425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4K38_RS27445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K38_RS27500	COG0728	peptidoglycan biosynthetic process
C4K38_RS27515	COG1252	NADH dehydrogenase
C4K38_RS27525	COG3121	Chaperone
C4K38_RS27530	COG3188	usher protein
C4K38_RS27555	COG0542	response to heat
C4K38_RS27585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS27625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4K38_RS27630	COG1047	Peptidyl-prolyl cis-trans
C4K38_RS27635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4K38_RS27640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4K38_RS27645	COG0196	riboflavin kinase activity
C4K38_RS27660	COG0268	Binds directly to 16S ribosomal RNA
C4K38_RS27665	COG3045	CreA protein
C4K38_RS27670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4K38_RS27675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4K38_RS27680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4K38_RS27685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4K38_RS27690	COG0142	geranyltranstransferase activity
C4K38_RS27695	COG2824	Alkylphosphonate utilization operon protein PhnA
C4K38_RS27700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K38_RS27705	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K38_RS27715	COG2862	Uncharacterized protein family, UPF0114
C4K38_RS27730	COG1067	ATP-dependent peptidase activity
C4K38_RS27750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K38_RS27760	COG0488	(ABC) transporter
C4K38_RS27770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K38_RS27785	COG2186	Transcriptional regulator
C4K38_RS27795	COG0523	cobalamin synthesis protein
C4K38_RS27800	COG2879	small protein
C4K38_RS27805	COG1966	Carbon starvation protein
C4K38_RS27840	COG1970	mechanosensitive ion channel activity
C4K38_RS27850	COG2813	Specifically methylates the guanine in position
C4K38_RS27860	COG1294	oxidase, subunit
C4K38_RS27865	COG1271	oxidase subunit
C4K38_RS27880	COG3093	addiction module antidote protein HigA
C4K38_RS27895	COG2252	PERMEase
C4K38_RS27900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K38_RS27925	COG1629	transport
C4K38_RS27940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K38_RS27945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K38_RS27950	COG3135	benzoate transporter
C4K38_RS27960	COG1309	transcriptional regulator
C4K38_RS27965	COG1082	Xylose isomerase domain protein TIM barrel
C4K38_RS27965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4K38_RS27990	COG0673	inositol 2-dehydrogenase activity
C4K38_RS28000	COG1053	succinate dehydrogenase
C4K38_RS28005	COG3485	protocatechuate 3,4-dioxygenase
C4K38_RS28010	COG3485	protocatechuate 3,4-dioxygenase
C4K38_RS28015	COG0583	DNA-binding transcription factor activity
C4K38_RS28020	COG2321	neutral zinc metallopeptidase
C4K38_RS28035	COG1946	Acyl-CoA thioesterase
C4K38_RS28045	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4K38_RS28055	COG0513	Belongs to the DEAD box helicase family
C4K38_RS28065	COG0697	spore germination
C4K38_RS28070	COG1522	sequence-specific DNA binding
C4K38_RS28075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K38_RS28075	COG1199	ATP-dependent helicase activity
C4K38_RS28085	COG3416	Protein conserved in bacteria
C4K38_RS28100	COG1643	Atp-dependent helicase
C4K38_RS28120	COG1522	sequence-specific DNA binding
C4K38_RS28135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K38_RS28140	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS28150	COG0351	phosphomethylpyrimidine kinase
C4K38_RS28155	COG0352	thiamine-phosphate diphosphorylase activity
C4K38_RS28160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K38_RS28175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K38_RS28180	COG1702	phosphate starvation-inducible protein PhoH
C4K38_RS28185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4K38_RS28190	COG4535	Mg2 and Co2 transporter CorC
C4K38_RS28195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4K38_RS28210	COG0495	leucyl-tRNA aminoacylation
C4K38_RS28230	COG2951	lytic endotransglycosylase activity
C4K38_RS28235	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4K38_RS28240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4K38_RS28245	COG0321	lipoyl(octanoyl) transferase activity
C4K38_RS28250	COG2921	Belongs to the UPF0250 family
C4K38_RS28255	COG1686	Belongs to the peptidase S11 family
C4K38_RS28265	COG2951	lytic endotransglycosylase activity
C4K38_RS28270	COG0772	Belongs to the SEDS family
C4K38_RS28275	COG0768	penicillin binding
C4K38_RS28280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4K38_RS28290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4K38_RS28295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4K38_RS28300	COG2094	Belongs to the DNA glycosylase MPG family
C4K38_RS28305	COG0586	Pfam SNARE associated Golgi protein
C4K38_RS28315	COG1346	cytolysis
C4K38_RS28335	COG0702	epimerase
C4K38_RS28350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K38_RS28355	COG3284	Transcriptional regulator
C4K38_RS28370	COG4303	Ethanolamine ammonia lyase large subunit
C4K38_RS28375	COG4302	ethanolamine ammonia-lyase activity
C4K38_RS28380	COG0456	acetyltransferase
C4K38_RS28385	COG0586	Pfam SNARE associated Golgi protein
C4K38_RS28390	COG3228	Belongs to the MtfA family
C4K38_RS28395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4K38_RS28405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS28435	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K38_RS28440	COG3657	addiction module killer protein
C4K38_RS28450	COG3321	synthase
C4K38_RS28450	COG0604	alcohol dehydrogenase
C4K38_RS28455	COG0640	Transcriptional regulator
C4K38_RS28465	COG1722	exodeoxyribonuclease VII activity
C4K38_RS28470	COG0142	geranyltranstransferase activity
C4K38_RS28475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4K38_RS28480	COG4206	TonB-dependent receptor
C4K38_RS28485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K38_RS28495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4K38_RS28505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4K38_RS28515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4K38_RS28520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K38_RS28535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K38_RS28535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K38_RS28540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K38_RS28550	COG2264	protein methyltransferase activity
C4K38_RS28555	COG3118	belongs to the thioredoxin family
C4K38_RS28585	COG3047	cAMP biosynthetic process
C4K38_RS28590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K38_RS28600	COG1201	RNA secondary structure unwinding
C4K38_RS28605	COG2814	Major facilitator Superfamily
C4K38_RS28610	COG1801	Protein of unknown function DUF72
C4K38_RS28615	COG3568	Endonuclease Exonuclease Phosphatase
C4K38_RS28620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K38_RS28625	COG0392	lysyltransferase activity
C4K38_RS28640	COG1335	isochorismatase
C4K38_RS28645	COG0629	single-stranded DNA binding
C4K38_RS28650	COG2814	Major facilitator Superfamily
C4K38_RS28655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4K38_RS28660	COG2193	ferroxidase activity
C4K38_RS28670	COG0203	ribosomal protein L17
C4K38_RS28675	COG0202	RNA polymerase activity
C4K38_RS28680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4K38_RS28685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4K38_RS28690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4K38_RS28695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4K38_RS28705	COG0200	Binds to the 23S rRNA
C4K38_RS28710	COG1841	ribosomal large subunit assembly
C4K38_RS28715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4K38_RS28720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4K38_RS28725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4K38_RS28730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4K38_RS28735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4K38_RS28740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4K38_RS28745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4K38_RS28750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4K38_RS28755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4K38_RS28760	COG0255	Belongs to the universal ribosomal protein uL29 family
C4K38_RS28765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4K38_RS28770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4K38_RS28775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4K38_RS28780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4K38_RS28785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4K38_RS28790	COG0089	rRNA binding
C4K38_RS28795	COG0088	Forms part of the polypeptide exit tunnel
C4K38_RS28800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4K38_RS28805	COG0051	transcription antitermination factor activity, RNA binding
C4K38_RS28810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K38_RS28815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K38_RS28820	COG0049	tRNA binding
C4K38_RS28825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4K38_RS28830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4K38_RS28835	COG0085	RNA polymerase activity
C4K38_RS28840	COG0222	ribosome binding
C4K38_RS28845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4K38_RS28850	COG0081	regulation of translation
C4K38_RS28855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4K38_RS28875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K38_RS28900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4K38_RS28940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4K38_RS28945	COG0739	heme binding
C4K38_RS28950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4K38_RS28955	COG0316	Belongs to the HesB IscA family
C4K38_RS28960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K38_RS28965	COG1981	membrane
C4K38_RS28980	COG4221	oxidoreductase activity
C4K38_RS28985	COG0537	adenosine 5'-monophosphoramidase activity
C4K38_RS28990	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4K38_RS28995	COG1765	OsmC-like protein
C4K38_RS29010	COG0134	indole-3-glycerol-phosphate synthase activity
C4K38_RS29015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K38_RS29020	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K38_RS29030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K38_RS29035	COG0546	phosphoglycolate phosphatase activity
C4K38_RS29040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4K38_RS29045	COG1454	alcohol dehydrogenase
C4K38_RS29055	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K38_RS29065	COG3842	ATPase activity
C4K38_RS29070	COG2197	response regulator
C4K38_RS29075	COG4585	Histidine kinase
C4K38_RS29085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K38_RS29090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K38_RS29095	COG3178	'Phosphotransferase
C4K38_RS29100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4K38_RS29105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K38_RS29110	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4K38_RS29115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4K38_RS29120	COG2967	ApaG domain
C4K38_RS29125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K38_RS29130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K38_RS29135	COG2766	serine protein kinase
C4K38_RS29140	COG2718	Belongs to the UPF0229 family
C4K38_RS29145	COG2719	SpoVR family
C4K38_RS29150	COG0617	tRNA 3'-terminal CCA addition
C4K38_RS29160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K38_RS29165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4K38_RS29170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4K38_RS29175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4K38_RS29180	COG0358	DNA primase activity
C4K38_RS29185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4K38_RS29220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K38_RS29225	COG1025	Belongs to the peptidase M16 family
C4K38_RS29235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K38_RS29240	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4K38_RS29250	COG0535	radical SAM domain protein
C4K38_RS29275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K38_RS29280	COG2258	MOSC domain
C4K38_RS29285	COG0583	DNA-binding transcription factor activity
C4K38_RS29290	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS29295	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS29300	COG3706	GGDEF domain
C4K38_RS29305	COG1960	acyl-CoA dehydrogenase activity
C4K38_RS29325	COG2226	methyltransferase
C4K38_RS29325	COG1073	alpha beta
C4K38_RS29330	COG0156	8-amino-7-oxononanoate synthase activity
C4K38_RS29335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4K38_RS29345	COG3585	molybdate ion transport
C4K38_RS29345	COG2005	Transcriptional regulator
C4K38_RS29355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4K38_RS29370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4K38_RS29375	COG0745	RESPONSE REGULATOR receiver
C4K38_RS29390	COG1595	DNA-templated transcription, initiation
C4K38_RS29395	COG3712	iron ion homeostasis
C4K38_RS29400	COG4774	siderophore transport
C4K38_RS29420	COG0625	glutathione transferase activity
C4K38_RS29425	COG4452	Inner membrane protein CreD
C4K38_RS29430	COG2205	protein histidine kinase activity
C4K38_RS29435	COG0745	RESPONSE REGULATOR receiver
C4K38_RS29440	COG4067	protein conserved in archaea
C4K38_RS29440	COG0189	ligase activity
C4K38_RS29445	COG0204	Acyl-transferase
C4K38_RS29455	COG1063	alcohol dehydrogenase
C4K38_RS29485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K38_RS29505	COG1017	nitric oxide dioxygenase activity
C4K38_RS29505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K38_RS29515	COG4638	Rieske (2fe-2S)
C4K38_RS29525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4K38_RS29530	COG0247	lactate metabolic process
C4K38_RS29530	COG2181	nitrate reductase activity
C4K38_RS29535	COG1902	pentaerythritol trinitrate reductase activity
C4K38_RS29535	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K38_RS29585	COG3246	L-lysine catabolic process to acetate
C4K38_RS29590	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K38_RS29620	COG1760	l-serine dehydratase
C4K38_RS29630	COG4176	ABC-type proline glycine betaine transport system permease component
C4K38_RS29635	COG4175	Glycine betaine
C4K38_RS29640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K38_RS29645	COG1309	transcriptional regulator
C4K38_RS29650	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS29655	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K38_RS29670	COG0312	modulator of DNA gyrase
C4K38_RS29675	COG0477	Major facilitator Superfamily
C4K38_RS29680	COG0513	Belongs to the DEAD box helicase family
C4K38_RS29685	COG2081	HI0933 family
C4K38_RS29690	COG1289	transmembrane transporter activity
C4K38_RS29700	COG2153	protein acetylation
C4K38_RS29710	COG1451	nucleotide metabolic process
C4K38_RS29765	COG0126	phosphoglycerate kinase activity
C4K38_RS29770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4K38_RS29780	COG4106	trans-aconitate 2-methyltransferase activity
C4K38_RS29785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4K38_RS29790	COG1422	Protein of unknown function (DUF1090)
C4K38_RS29815	COG2814	Major facilitator Superfamily
C4K38_RS29840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4K38_RS29845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4K38_RS29860	COG0513	Belongs to the DEAD box helicase family
C4K38_RS29865	COG2353	YceI-like domain
C4K38_RS29870	COG3038	cytochrome b561
C4K38_RS29880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4K38_RS29905	COG1272	protein, Hemolysin III
C4K38_RS29925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K38_RS29945	COG3052	prosthetic group binding
C4K38_RS29950	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4K38_RS30005	COG2198	Histidine kinase
C4K38_RS30005	COG0784	Response regulator, receiver
C4K38_RS30005	COG0643	Histidine kinase
C4K38_RS30030	COG0189	ligase activity
C4K38_RS30040	COG1678	Uncharacterized ACR, COG1678
C4K38_RS30045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4K38_RS30050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4K38_RS30055	COG0540	Belongs to the ATCase OTCase family
C4K38_RS30060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K38_RS30070	COG0791	NLP P60 protein
C4K38_RS30095	COG1872	DUF167
C4K38_RS30100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K38_RS30105	COG2813	Specifically methylates the guanine in position
C4K38_RS30105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K38_RS30115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4K38_RS30120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4K38_RS30130	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
C4K38_RS30135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4K38_RS30140	COG2022	thiamine diphosphate biosynthetic process
C4K38_RS30150	COG2363	Small membrane protein
C4K38_RS30155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K38_RS30165	COG2177	Part of the ABC transporter FtsEX involved in
C4K38_RS30170	COG2884	Cell division ATP-binding protein ftsE
C4K38_RS30175	COG0552	protein localization to endoplasmic reticulum
C4K38_RS30180	COG0612	Peptidase, M16
C4K38_RS30185	COG0612	Peptidase, M16
C4K38_RS30190	COG0742	ribosomal rna small subunit methyltransferase
C4K38_RS30225	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K38_RS30230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4K38_RS30235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4K38_RS30240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4K38_RS30250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K38_RS30260	COG0129	dihydroxy-acid dehydratase activity
C4K38_RS30285	COG1823	symporter activity
C4K38_RS30300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K38_RS30315	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K38_RS30320	COG1178	ABC-type Fe3 transport system permease component
C4K38_RS30325	COG3842	ATPase activity
C4K38_RS30330	COG0583	DNA-binding transcription factor activity
C4K38_RS30340	COG0789	Transcriptional regulator
C4K38_RS30345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4K38_RS30350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4K38_RS30355	COG0730	response to heat
C4K38_RS30365	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C4K38_RS30370	COG0494	nUDIX hydrolase
C4K38_RS30385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K38_RS30390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4K38_RS30395	COG2234	aminopeptidase activity
C4K38_RS30400	COG3204	pilus organization
C4K38_RS30405	COG3204	pilus organization
C4K38_RS30410	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K38_RS30415	COG0277	FAD linked oxidase domain protein
C4K38_RS30420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K38_RS30430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS30435	COG1683	Conserved Protein
C4K38_RS30465	COG1177	transmembrane transport
C4K38_RS30470	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K38_RS30475	COG3842	ATPase activity
C4K38_RS30495	COG0174	glutamine synthetase
C4K38_RS30500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K38_RS30505	COG0174	glutamine synthetase
C4K38_RS30520	COG1116	anion transmembrane transporter activity
C4K38_RS30525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K38_RS30530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K38_RS30535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K38_RS30540	COG0431	NADPH-dependent FMN reductase
C4K38_RS30545	COG0450	alkyl hydroperoxide reductase
C4K38_RS30555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4K38_RS30555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K38_RS30560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K38_RS30570	COG1522	sequence-specific DNA binding
C4K38_RS30580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4K38_RS30585	COG0840	transmembrane signaling receptor activity
C4K38_RS30600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K38_RS30600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K38_RS30605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K38_RS30620	COG0509	glycine decarboxylation via glycine cleavage system
C4K38_RS30625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K38_RS30630	COG1178	ABC-type Fe3 transport system permease component
C4K38_RS30640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K38_RS30645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K38_RS30650	COG0006	proline dipeptidase activity
C4K38_RS30655	COG3079	Belongs to the UPF0149 family
C4K38_RS30675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4K38_RS30685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K38_RS30690	COG1129	ABC transporter
C4K38_RS30690	COG0842	Transport permease protein
C4K38_RS30695	COG0842	Transport permease protein
C4K38_RS30705	COG0604	alcohol dehydrogenase
C4K38_RS30710	COG2271	Major facilitator Superfamily
C4K38_RS30725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4K38_RS30740	COG2186	Transcriptional regulator
C4K38_RS30745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS30750	COG0765	amino acid transport
C4K38_RS30755	COG0765	amino acid transport
C4K38_RS30760	COG1126	abc transporter atp-binding protein
C4K38_RS30765	COG0248	Ppx GppA phosphatase
C4K38_RS30770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4K38_RS30780	COG0586	Pfam SNARE associated Golgi protein
C4K38_RS30790	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4K38_RS30795	COG1671	Belongs to the UPF0178 family
C4K38_RS30800	COG0672	)-iron permease
C4K38_RS30805	COG1280	lysine exporter protein (LysE YggA)
C4K38_RS30815	COG0488	(ABC) transporter
C4K38_RS30840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K38_RS30860	COG0181	hydroxymethylbilane synthase activity
C4K38_RS30870	COG0165	Argininosuccinate lyase
C4K38_RS30875	COG0625	glutathione transferase activity
C4K38_RS30895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K38_RS30905	COG1965	Belongs to the frataxin family
C4K38_RS30915	COG0019	diaminopimelate decarboxylase activity
C4K38_RS30920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K38_RS30930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K38_RS30935	COG1011	Hydrolase
C4K38_RS30945	COG0432	Pfam Uncharacterised protein family UPF0047
C4K38_RS30955	COG0004	ammonium transporteR
C4K38_RS30960	COG0347	Belongs to the P(II) protein family
C4K38_RS30975	COG0529	Catalyzes the synthesis of activated sulfate
C4K38_RS30985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K38_RS30990	COG0574	Belongs to the PEP-utilizing enzyme family
C4K38_RS30990	COG3848	Pyruvate phosphate dikinase
C4K38_RS30995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K38_RS31000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K38_RS31005	COG0606	chelatase, subunit chli
C4K38_RS31090	COG0583	DNA-binding transcription factor activity
C4K38_RS31095	COG0534	Mate efflux family protein
C4K38_RS31110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K38_RS31115	COG0427	acetyl-CoA hydrolase
C4K38_RS31130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4K38_RS31135	COG0251	oxidation-reduction process
C4K38_RS31140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS31155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K38_RS31165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K38_RS31170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K38_RS31180	COG1012	belongs to the aldehyde dehydrogenase family
C4K38_RS31190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4K38_RS31195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4K38_RS31200	COG0747	negative chemotaxis
C4K38_RS31205	COG2003	Belongs to the UPF0758 family
C4K38_RS31210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4K38_RS31215	COG0756	dUTP diphosphatase activity
C4K38_RS31220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K38_RS31225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K38_RS31230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4K38_RS31235	COG0708	Exodeoxyribonuclease III
C4K38_RS31245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4K38_RS31250	COG1561	YicC-like family, N-terminal region
C4K38_RS31255	COG0194	GDP metabolic process
C4K38_RS31260	COG1758	RNA polymerase activity
C4K38_RS31265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K38_RS31290	COG0848	biopolymer transport protein
C4K38_RS31300	COG0583	DNA-binding transcription factor activity
C4K38_RS31305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4K38_RS31355	COG3755	Protein conserved in bacteria
C4K38_RS31410	COG0515	serine threonine protein kinase
C4K38_RS31415	COG0631	protein serine/threonine phosphatase activity
C4K38_RS31530	COG3161	chorismate lyase activity
C4K38_RS31535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4K38_RS31555	COG1253	flavin adenine dinucleotide binding
C4K38_RS31560	COG0739	heme binding
C4K38_RS31580	COG0704	Plays a role in the regulation of phosphate uptake
C4K38_RS31585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4K38_RS31590	COG0573	inorganic phosphate transmembrane transporter activity
C4K38_RS31605	COG0477	Major facilitator Superfamily
C4K38_RS31610	COG1607	acyl-coa hydrolase
C4K38_RS31640	COG0583	DNA-binding transcription factor activity
C4K38_RS31645	COG1027	Aspartate ammonia-lyase
C4K38_RS31660	COG1115	amino acid carrier protein
C4K38_RS31665	COG0252	asparaginase activity
C4K38_RS31690	COG2391	methyltransferase activity
C4K38_RS31720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K38_RS31725	COG0765	amino acid transport
C4K38_RS31740	COG5016	pyruvate
C4K38_RS31740	COG0511	ligase activity, forming carbon-carbon bonds
C4K38_RS31745	COG0439	Biotin carboxylase
C4K38_RS31750	COG0583	DNA-binding transcription factor activity
C4K38_RS31770	COG0210	DNA helicase
C4K38_RS31795	COG4651	solute:proton antiporter activity
C4K38_RS31795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K38_RS31800	COG1607	acyl-coa hydrolase
C4K38_RS31805	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4K38_RS31815	COG0523	cobalamin synthesis protein
C4K38_RS31840	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K38_RS31845	COG1469	GTP cyclohydrolase I activity
C4K38_RS31850	COG1121	(ABC) transporter
C4K38_RS31860	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4K38_RS31865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K38_RS31875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K38_RS31880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K38_RS31890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K38_RS31895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4K38_RS31900	COG2217	Heavy metal translocating P-type atpase
C4K38_RS31920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4K38_RS31925	COG2267	carboxylic ester hydrolase activity
C4K38_RS31930	COG0671	phosphoesterase, PA-phosphatase related
C4K38_RS31930	COG2453	phosphatase
C4K38_RS31945	COG4589	Belongs to the CDS family
C4K38_RS31950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K38_RS31960	COG1280	lysine exporter protein (LysE YggA)
C4K38_RS31965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K38_RS31970	COG2755	lipolytic protein G-D-S-L family
C4K38_RS31970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K38_RS32020	COG0297	glycogen (starch) synthase activity
C4K38_RS32035	COG0625	glutathione transferase activity
C4K38_RS32040	COG0583	DNA-binding transcription factor activity
C4K38_RS32045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K38_RS32060	COG0494	nUDIX hydrolase
C4K38_RS32065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K38_RS32080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K38_RS32085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K38_RS32090	COG0494	nUDIX hydrolase
C4K38_RS32140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K38_RS32145	COG1349	DNA-binding transcription factor activity
C4K38_RS32150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K38_RS32155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4K38_RS32160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4K38_RS32165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4K38_RS32170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4K38_RS32175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4K38_RS32180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4K38_RS32190	COG0356	it plays a direct role in the translocation of protons across the membrane
C4K38_RS32195	COG3312	ion transport
C4K38_RS32200	COG1475	DNA binding
C4K38_RS32205	COG1192	Involved in chromosome partitioning
C4K38_RS32210	COG0357	Ribosomal RNA small subunit methyltransferase G
C4K38_RS32215	COG0445	tRNA wobble uridine modification
C4K38_RS32225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K38_RS32230	COG0706	membrane insertase activity
C4K38_RS32235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4K38_RS32240	COG0594	ribonuclease P activity
C4K38_RS32245	COG0230	Belongs to the bacterial ribosomal protein bL34 family