locus-tag	class	description
C4K32_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K32_RS00010	COG0592	DNA-directed DNA polymerase activity
C4K32_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K32_RS00020	COG0187	DNA topoisomerase II activity
C4K32_RS00045	COG5002	protein histidine kinase activity
C4K32_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4K32_RS00060	COG0751	glycine-tRNA ligase activity
C4K32_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
C4K32_RS00070	COG2818	Glycosylase
C4K32_RS00090	COG0569	domain protein
C4K32_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4K32_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K32_RS00105	COG0242	peptide deformylase activity
C4K32_RS00115	COG0758	DNA mediated transformation
C4K32_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
C4K32_RS00130	COG0408	coproporphyrinogen oxidase activity
C4K32_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K32_RS00150	COG3119	arylsulfatase activity
C4K32_RS00175	COG0159	tryptophan synthase activity
C4K32_RS00180	COG0133	tryptophan synthase activity
C4K32_RS00195	COG3360	Dodecin
C4K32_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS00210	COG1764	response to oxidative stress
C4K32_RS00240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4K32_RS00245	COG0339	signal peptide processing
C4K32_RS00250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4K32_RS00285	COG0659	secondary active sulfate transmembrane transporter activity
C4K32_RS00295	COG1565	acr, cog1565
C4K32_RS00295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K32_RS00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K32_RS00305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4K32_RS00335	COG0109	protoheme IX farnesyltransferase activity
C4K32_RS00350	COG2011	ABC-type metal ion transport system permease component
C4K32_RS00355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K32_RS00365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K32_RS00370	COG1121	(ABC) transporter
C4K32_RS00375	COG0735	belongs to the Fur family
C4K32_RS00380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4K32_RS00400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4K32_RS00415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K32_RS00430	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K32_RS00435	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K32_RS00440	COG5002	protein histidine kinase activity
C4K32_RS00445	COG2204	response regulator
C4K32_RS00455	COG5487	UPF0391 membrane protein
C4K32_RS00465	COG1301	dicarboxylic acid transport
C4K32_RS00470	COG0700	Nucleoside recognition
C4K32_RS00475	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K32_RS00485	COG1127	ABC transporter
C4K32_RS00490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K32_RS00500	COG0612	Peptidase, M16
C4K32_RS00505	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K32_RS00510	COG0861	Integral membrane protein TerC family
C4K32_RS00515	COG2851	Citrate transporter
C4K32_RS00555	COG0427	acetyl-CoA hydrolase
C4K32_RS00575	COG0583	DNA-binding transcription factor activity
C4K32_RS00580	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS00635	COG3712	iron ion homeostasis
C4K32_RS00640	COG1595	DNA-templated transcription, initiation
C4K32_RS00645	COG0840	transmembrane signaling receptor activity
C4K32_RS00675	COG1802	Transcriptional regulator
C4K32_RS00685	COG3300	MHYT domain
C4K32_RS00685	COG5001	Diguanylate cyclase
C4K32_RS00700	COG1538	Outer membrane efflux protein
C4K32_RS00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS00715	COG2175	clavaminate synthase activity
C4K32_RS00725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K32_RS00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS00820	COG0529	Catalyzes the synthesis of activated sulfate
C4K32_RS00835	COG0330	HflC and HflK could
C4K32_RS00870	COG1289	transmembrane transporter activity
C4K32_RS00880	COG1566	PFAM secretion protein HlyD family protein
C4K32_RS00895	COG5339	Protein conserved in bacteria
C4K32_RS00900	COG0457	Tetratricopeptide repeat
C4K32_RS00905	COG0726	polysaccharide deacetylase
C4K32_RS00905	COG1649	PFAM Uncharacterised BCR, COG1649
C4K32_RS00910	COG1215	transferase activity, transferring glycosyl groups
C4K32_RS00920	COG1881	PFAM PEBP family protein
C4K32_RS00925	COG2304	oxidoreductase activity
C4K32_RS00930	COG1595	DNA-templated transcription, initiation
C4K32_RS01005	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K32_RS01015	COG0745	RESPONSE REGULATOR receiver
C4K32_RS01020	COG2199	diguanylate cyclase activity
C4K32_RS01040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4K32_RS01050	COG4208	sulfate ABC transporter
C4K32_RS01055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4K32_RS01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS01095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS01120	COG4771	TonB-dependent receptor
C4K32_RS01180	COG2807	transmembrane transport
C4K32_RS01185	COG0590	tRNA wobble adenosine to inosine editing
C4K32_RS01195	COG0583	DNA-binding transcription factor activity
C4K32_RS01230	COG0765	amino acid transport
C4K32_RS01235	COG0765	amino acid transport
C4K32_RS01240	COG1126	abc transporter atp-binding protein
C4K32_RS01245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS01250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K32_RS01255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS01265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS01280	COG2011	ABC-type metal ion transport system permease component
C4K32_RS01285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K32_RS01315	COG1126	abc transporter atp-binding protein
C4K32_RS01320	COG0765	amino acid transport
C4K32_RS01325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS01330	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4K32_RS01335	COG1045	serine acetyltransferase
C4K32_RS01340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K32_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS01360	COG0583	DNA-binding transcription factor activity
C4K32_RS01375	COG0667	Aldo Keto reductase
C4K32_RS01380	COG1487	ribonuclease activity
C4K32_RS01390	COG2175	clavaminate synthase activity
C4K32_RS01395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS01400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K32_RS01405	COG4521	taurine ABC transporter
C4K32_RS01410	COG2918	glutathione biosynthetic process
C4K32_RS01420	COG2183	response to ionizing radiation
C4K32_RS01430	COG2205	protein histidine kinase activity
C4K32_RS01435	COG0189	ligase activity
C4K32_RS01440	COG0189	ligase activity
C4K32_RS01440	COG4067	protein conserved in archaea
C4K32_RS01445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4K32_RS01455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4K32_RS01460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4K32_RS01500	COG0514	ATP-dependent DNA helicase (RecQ)
C4K32_RS01505	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS01505	COG1024	Enoyl-CoA hydratase
C4K32_RS01510	COG0824	Thioesterase
C4K32_RS01520	COG0243	molybdopterin cofactor binding
C4K32_RS01525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4K32_RS01535	COG1652	LysM domain
C4K32_RS01540	COG1011	Hydrolase
C4K32_RS01545	COG0494	nUDIX hydrolase
C4K32_RS01570	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4K32_RS01580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4K32_RS01585	COG1088	dTDP-glucose 4,6-dehydratase activity
C4K32_RS01590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K32_RS01600	COG2957	Belongs to the agmatine deiminase family
C4K32_RS01640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K32_RS01645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K32_RS01650	COG1845	cytochrome c oxidase, subunit III
C4K32_RS01655	COG1845	cytochrome c oxidase, subunit III
C4K32_RS01670	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4K32_RS01725	COG0582	viral genome integration into host DNA
C4K32_RS01750	COG4215	(ABC) transporter
C4K32_RS01790	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4K32_RS01795	COG1194	a g-specific adenine glycosylase
C4K32_RS01810	COG2223	nitrite transmembrane transporter activity
C4K32_RS01815	COG0131	Imidazoleglycerol-phosphate dehydratase
C4K32_RS01820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K32_RS01830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4K32_RS01835	COG0107	imidazoleglycerol-phosphate synthase activity
C4K32_RS01845	COG2861	carbohydrate metabolic process
C4K32_RS01850	COG0793	Belongs to the peptidase S41A family
C4K32_RS01855	COG4942	peptidase
C4K32_RS01860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4K32_RS01875	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4K32_RS01895	COG3852	Histidine kinase
C4K32_RS01900	COG0477	Major facilitator Superfamily
C4K32_RS01905	COG0583	DNA-binding transcription factor activity
C4K32_RS01910	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS01915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K32_RS01920	COG1024	Enoyl-CoA hydratase
C4K32_RS01925	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS01930	COG0183	Belongs to the thiolase family
C4K32_RS01965	COG0301	tRNA thio-modification
C4K32_RS01965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K32_RS01970	COG1217	gtp-binding protein TYPA
C4K32_RS01980	COG0058	SHG alpha-glucan phosphorylase activity
C4K32_RS01985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4K32_RS02010	COG0402	S-adenosylhomocysteine deaminase activity
C4K32_RS02015	COG2188	Transcriptional regulator
C4K32_RS02025	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4K32_RS02030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K32_RS02040	COG4176	ABC-type proline glycine betaine transport system permease component
C4K32_RS02045	COG0517	IMP dehydrogenase activity
C4K32_RS02045	COG4175	Glycine betaine
C4K32_RS02050	COG2986	histidine ammonia-lyase
C4K32_RS02055	COG2986	histidine ammonia-lyase
C4K32_RS02065	COG1228	amidohydrolase
C4K32_RS02075	COG0596	Alpha beta hydrolase
C4K32_RS02080	COG1490	D-aminoacyl-tRNA deacylase activity
C4K32_RS02085	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K32_RS02090	COG2943	transferase activity, transferring hexosyl groups
C4K32_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS02100	COG0765	amino acid transport
C4K32_RS02105	COG1126	abc transporter atp-binding protein
C4K32_RS02110	COG0840	transmembrane signaling receptor activity
C4K32_RS02125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K32_RS02130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K32_RS02135	COG0140	phosphoribosyl-ATP diphosphatase activity
C4K32_RS02140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K32_RS02145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K32_RS02155	COG2226	methyltransferase
C4K32_RS02200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4K32_RS02205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4K32_RS02215	COG0018	arginyl-trna synthetase
C4K32_RS02220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4K32_RS02225	COG0254	rRNA binding
C4K32_RS02235	COG0281	malic enzyme
C4K32_RS02270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K32_RS02275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K32_RS02290	COG0067	glutamate synthase
C4K32_RS02290	COG0069	glutamate synthase activity
C4K32_RS02290	COG0070	glutamate synthase
C4K32_RS02295	COG0493	'glutamate synthase
C4K32_RS02300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4K32_RS02305	COG3111	PFAM Bacterial OB fold (BOF) protein
C4K32_RS02310	COG2814	Major facilitator Superfamily
C4K32_RS02315	COG0583	DNA-binding transcription factor activity
C4K32_RS02335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K32_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS02350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K32_RS02360	COG2226	methyltransferase
C4K32_RS02365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K32_RS02390	COG2986	histidine ammonia-lyase
C4K32_RS02415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS02420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS02435	COG1192	Involved in chromosome partitioning
C4K32_RS02440	COG3118	belongs to the thioredoxin family
C4K32_RS02445	COG4680	protein conserved in bacteria
C4K32_RS02455	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K32_RS02460	COG3264	Mechanosensitive ion channel
C4K32_RS02460	COG1196	nuclear chromosome segregation
C4K32_RS02465	COG3263	regulation of cellular component size
C4K32_RS02485	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS02490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K32_RS02490	COG0506	proline dehydrogenase activity
C4K32_RS02490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K32_RS02495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K32_RS02500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4K32_RS02505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K32_RS02525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4K32_RS02530	COG0859	PFAM glycosyl transferase family 9
C4K32_RS02535	COG0859	PFAM glycosyl transferase family 9
C4K32_RS02540	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS02565	COG2192	nodulation
C4K32_RS02570	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS02595	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS02610	COG1132	(ABC) transporter
C4K32_RS02630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4K32_RS02630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4K32_RS02640	COG0667	Aldo Keto reductase
C4K32_RS02660	COG1519	Transferase
C4K32_RS02665	COG1538	Outer membrane efflux protein
C4K32_RS02670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4K32_RS02685	COG0494	nUDIX hydrolase
C4K32_RS02695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4K32_RS02700	COG3150	esterase
C4K32_RS02735	COG0560	Phosphoserine phosphatase
C4K32_RS02735	COG3830	Belongs to the UPF0237 family
C4K32_RS02740	COG0688	phosphatidylethanolamine metabolic process
C4K32_RS02765	COG1162	GTPase activity
C4K32_RS02770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4K32_RS02775	COG2860	membrane
C4K32_RS02785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4K32_RS02785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4K32_RS02790	COG0802	atpase or kinase
C4K32_RS02795	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K32_RS02800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K32_RS02805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4K32_RS02810	COG1923	regulation of RNA biosynthetic process
C4K32_RS02815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4K32_RS02820	COG0330	HflC and HflK could
C4K32_RS02825	COG0330	HflC and HflK could
C4K32_RS02830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4K32_RS02835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4K32_RS02840	COG0840	transmembrane signaling receptor activity
C4K32_RS02845	COG1178	ABC-type Fe3 transport system permease component
C4K32_RS02850	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K32_RS02865	COG0557	exoribonuclease II activity
C4K32_RS02870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4K32_RS02875	COG0360	Binds together with S18 to 16S ribosomal RNA
C4K32_RS02880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4K32_RS02890	COG0359	binds to the 23S rRNA
C4K32_RS02895	COG0305	Participates in initiation and elongation during chromosome replication
C4K32_RS02900	COG1032	radical SAM domain protein
C4K32_RS02915	COG2307	Protein conserved in bacteria
C4K32_RS02915	COG2308	Evidence 4 Homologs of previously reported genes of
C4K32_RS02925	COG0494	nUDIX hydrolase
C4K32_RS02945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4K32_RS02950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4K32_RS02955	COG0583	DNA-binding transcription factor activity
C4K32_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS02965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS02975	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4K32_RS03000	COG4221	oxidoreductase activity
C4K32_RS03020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4K32_RS03025	COG0830	nickel cation binding
C4K32_RS03030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4K32_RS03045	COG2982	Protein involved in outer membrane biogenesis
C4K32_RS03050	COG0583	DNA-binding transcription factor activity
C4K32_RS03055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K32_RS03065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4K32_RS03070	COG0697	spore germination
C4K32_RS03075	COG2207	Transcriptional regulator
C4K32_RS03090	COG0443	Heat shock 70 kDa protein
C4K32_RS03095	COG0484	heat shock protein binding
C4K32_RS03100	COG0789	Transcriptional regulator
C4K32_RS03110	COG0804	urea catabolic process
C4K32_RS03115	COG0832	Belongs to the urease beta subunit family
C4K32_RS03130	COG0831	urea catabolic process
C4K32_RS03135	COG0829	nickel cation binding
C4K32_RS03145	COG0411	ABC transporter
C4K32_RS03160	COG0683	leucine binding
C4K32_RS03165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K32_RS03175	COG1120	ATPase activity
C4K32_RS03215	COG3657	addiction module killer protein
C4K32_RS03225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4K32_RS03235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K32_RS03335	COG4397	Mu-like prophage major head subunit gpT
C4K32_RS03355	COG5005	Phage virion morphogenesis
C4K32_RS03370	COG4383	Mu-like prophage protein gp29
C4K32_RS03420	COG5566	PFAM Mor transcription activator
C4K32_RS03505	COG2095	MarC family integral membrane protein
C4K32_RS03515	COG0151	Belongs to the GarS family
C4K32_RS03520	COG0138	bifunctional purine biosynthesis protein purh
C4K32_RS03530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K32_RS03540	COG2264	protein methyltransferase activity
C4K32_RS03555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K32_RS03585	COG0023	Translation Initiation Factor
C4K32_RS03590	COG1166	arginine decarboxylase activity
C4K32_RS03595	COG0534	Mate efflux family protein
C4K32_RS03600	COG2373	Large extracellular alpha-helical protein
C4K32_RS03610	COG4953	penicillin-binding protein 1C
C4K32_RS03620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K32_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS03745	COG2217	Heavy metal translocating P-type atpase
C4K32_RS03775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4K32_RS03780	COG0583	DNA-binding transcription factor activity
C4K32_RS03785	COG0477	Major facilitator Superfamily
C4K32_RS03790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4K32_RS03805	COG0387	Pfam Sodium calcium exchanger
C4K32_RS03830	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4K32_RS03835	COG4603	Belongs to the binding-protein-dependent transport system permease family
C4K32_RS03840	COG3845	ABC transporter
C4K32_RS03850	COG1309	transcriptional regulator
C4K32_RS03855	COG2233	PERMEase
C4K32_RS03905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4K32_RS03910	COG1074	ATP-dependent DNA helicase activity
C4K32_RS03915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K32_RS03925	COG2199	diguanylate cyclase activity
C4K32_RS03980	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4K32_RS03985	COG3483	tryptophan 2,3-dioxygenase activity
C4K32_RS03990	COG1113	amino acid transport
C4K32_RS03995	COG0543	2 iron, 2 sulfur cluster binding
C4K32_RS03995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K32_RS04000	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4K32_RS04005	COG4638	Rieske (2fe-2S)
C4K32_RS04015	COG1522	sequence-specific DNA binding
C4K32_RS04025	COG1113	amino acid transport
C4K32_RS04030	COG0583	DNA-binding transcription factor activity
C4K32_RS04045	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K32_RS04050	COG0583	DNA-binding transcription factor activity
C4K32_RS04065	COG2610	gluconate transmembrane transporter activity
C4K32_RS04075	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4K32_RS04110	COG0840	transmembrane signaling receptor activity
C4K32_RS04150	COG1309	transcriptional regulator
C4K32_RS04245	COG0247	lactate metabolic process
C4K32_RS04250	COG1620	l-lactate permease
C4K32_RS04255	COG2186	Transcriptional regulator
C4K32_RS04260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4K32_RS04265	COG0733	neurotransmitter:sodium symporter activity
C4K32_RS04275	COG2914	Belongs to the UPF0125 (RnfH) family
C4K32_RS04280	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4K32_RS04290	COG0497	DNA recombination
C4K32_RS04295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4K32_RS04300	COG0443	Heat shock 70 kDa protein
C4K32_RS04305	COG0484	heat shock protein binding
C4K32_RS04310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4K32_RS04315	COG0505	Belongs to the CarA family
C4K32_RS04320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4K32_RS04325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K32_RS04340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4K32_RS04350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4K32_RS04355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K32_RS04360	COG0149	triose-phosphate isomerase activity
C4K32_RS04365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4K32_RS04385	COG0195	Participates in both transcription termination and antitermination
C4K32_RS04390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4K32_RS04395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4K32_RS04400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4K32_RS04405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4K32_RS04410	COG1185	polyribonucleotide nucleotidyltransferase activity
C4K32_RS04420	COG0582	viral genome integration into host DNA
C4K32_RS04530	COG0583	DNA-binding transcription factor activity
C4K32_RS04535	COG2957	Belongs to the agmatine deiminase family
C4K32_RS04555	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS04585	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K32_RS04600	COG0084	hydrolase, TatD family'
C4K32_RS04605	COG1609	Transcriptional regulator
C4K32_RS04610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K32_RS04610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K32_RS04615	COG1105	Belongs to the carbohydrate kinase PfkB family
C4K32_RS04620	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4K32_RS04620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K32_RS04620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K32_RS04635	COG2814	Major facilitator Superfamily
C4K32_RS04645	COG1309	transcriptional regulator
C4K32_RS04655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4K32_RS04660	COG4774	siderophore transport
C4K32_RS04665	COG3128	pkhd-type hydroxylase
C4K32_RS04675	COG0019	diaminopimelate decarboxylase activity
C4K32_RS04700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4K32_RS04710	COG4608	Belongs to the ABC transporter superfamily
C4K32_RS04715	COG0444	Belongs to the ABC transporter superfamily
C4K32_RS04720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K32_RS04725	COG0601	transmembrane transport
C4K32_RS04730	COG0747	negative chemotaxis
C4K32_RS04740	COG0747	negative chemotaxis
C4K32_RS04745	COG0747	negative chemotaxis
C4K32_RS04755	COG1396	sequence-specific DNA binding
C4K32_RS04755	COG1917	Cupin 2, conserved barrel domain protein
C4K32_RS04770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4K32_RS04775	COG4178	(ABC) transporter
C4K32_RS04795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K32_RS04805	COG2271	Major facilitator Superfamily
C4K32_RS04810	COG2721	sulfolactate sulfo-lyase activity
C4K32_RS04820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K32_RS04830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K32_RS04835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K32_RS04840	COG0154	amidase activity
C4K32_RS04845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K32_RS04850	COG1077	Cell shape determining protein MreB Mrl
C4K32_RS04855	COG1792	Involved in formation and maintenance of cell shape
C4K32_RS04865	COG0424	maF-like protein
C4K32_RS04870	COG1530	ribonuclease E activity
C4K32_RS04880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K32_RS04885	COG0312	modulator of DNA gyrase
C4K32_RS04890	COG3028	Belongs to the UPF0307 family
C4K32_RS04895	COG0312	modulator of DNA gyrase
C4K32_RS04930	COG1660	Displays ATPase and GTPase activities
C4K32_RS04945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4K32_RS04950	COG1137	ATPase activity
C4K32_RS04955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4K32_RS04965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4K32_RS04975	COG1127	ABC transporter
C4K32_RS04980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K32_RS04985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4K32_RS05005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4K32_RS05010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4K32_RS05015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K32_RS05020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K32_RS05025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K32_RS05040	COG0175	sulfate reduction
C4K32_RS05050	COG0204	Acyl-transferase
C4K32_RS05055	COG0280	phosphate acetyltransferase
C4K32_RS05055	COG0857	belongs to the CobB CobQ family
C4K32_RS05070	COG0386	Belongs to the glutathione peroxidase family
C4K32_RS05085	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4K32_RS05095	COG0492	ferredoxin-NADP+ reductase activity
C4K32_RS05110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K32_RS05115	COG0302	gtp cyclohydrolase
C4K32_RS05130	COG0789	Transcriptional regulator
C4K32_RS05140	COG1366	Belongs to the anti-sigma-factor antagonist family
C4K32_RS05150	COG0583	DNA-binding transcription factor activity
C4K32_RS05155	COG1380	Effector of murein hydrolase LrgA
C4K32_RS05160	COG1346	cytolysis
C4K32_RS05170	COG0596	Alpha beta hydrolase
C4K32_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS05195	COG2909	trisaccharide binding
C4K32_RS05205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4K32_RS05210	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K32_RS05230	COG2226	methyltransferase
C4K32_RS05275	COG0814	amino acid
C4K32_RS05280	COG1760	l-serine dehydratase
C4K32_RS05285	COG0583	DNA-binding transcription factor activity
C4K32_RS05295	COG4772	TonB-dependent receptor
C4K32_RS05300	COG3712	iron ion homeostasis
C4K32_RS05305	COG1595	DNA-templated transcription, initiation
C4K32_RS05325	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K32_RS05335	COG0697	spore germination
C4K32_RS05340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K32_RS05345	COG0583	DNA-binding transcription factor activity
C4K32_RS05365	COG1566	PFAM secretion protein HlyD family protein
C4K32_RS05385	COG0300	oxidoreductase activity
C4K32_RS05435	COG0662	Cupin 2, conserved barrel domain protein
C4K32_RS05435	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4K32_RS05450	COG1696	Membrane protein involved in D-alanine export
C4K32_RS05465	COG3420	alginic acid biosynthetic process
C4K32_RS05475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4K32_RS05480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS05485	COG1215	transferase activity, transferring glycosyl groups
C4K32_RS05495	COG3022	response to hydroperoxide
C4K32_RS05505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4K32_RS05510	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K32_RS05515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K32_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS05545	COG0513	Belongs to the DEAD box helicase family
C4K32_RS05555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS05560	COG4597	amino acid ABC transporter
C4K32_RS05565	COG0765	amino acid transport
C4K32_RS05570	COG1126	abc transporter atp-binding protein
C4K32_RS05575	COG2944	sequence-specific DNA binding
C4K32_RS05585	COG2186	Transcriptional regulator
C4K32_RS05590	COG2807	transmembrane transport
C4K32_RS05600	COG2827	Endonuclease containing a URI domain
C4K32_RS05615	COG3081	Nucleoid-associated protein
C4K32_RS05625	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4K32_RS05630	COG0525	valine-tRNA ligase activity
C4K32_RS05645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4K32_RS05650	COG0795	lipopolysaccharide-transporting ATPase activity
C4K32_RS05655	COG0795	lipopolysaccharide-transporting ATPase activity
C4K32_RS05660	COG0481	GTPase activity
C4K32_RS05665	COG0681	Belongs to the peptidase S26 family
C4K32_RS05675	COG0571	ribonuclease III activity
C4K32_RS05680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4K32_RS05685	COG1381	Involved in DNA repair and RecF pathway recombination
C4K32_RS05690	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4K32_RS05695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K32_RS05700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4K32_RS05700	COG0047	phosphoribosylformylglycinamidine synthase activity
C4K32_RS05710	COG1263	PTS System
C4K32_RS05710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K32_RS05710	COG2190	(PTS) system
C4K32_RS05715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K32_RS05715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K32_RS05720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K32_RS05725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4K32_RS05730	COG2188	Transcriptional regulator
C4K32_RS05745	COG0494	nUDIX hydrolase
C4K32_RS05765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4K32_RS05770	COG0477	Major facilitator Superfamily
C4K32_RS05775	COG4536	flavin adenine dinucleotide binding
C4K32_RS05785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4K32_RS05790	COG0228	four-way junction DNA binding
C4K32_RS05795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4K32_RS05800	COG0336	Belongs to the RNA methyltransferase TrmD family
C4K32_RS05805	COG0335	large ribosomal subunit rRNA binding
C4K32_RS05810	COG1607	acyl-coa hydrolase
C4K32_RS05820	COG4974	Belongs to the 'phage' integrase family
C4K32_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS05840	COG2205	protein histidine kinase activity
C4K32_RS05850	COG2197	response regulator
C4K32_RS05870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K32_RS05885	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS05890	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K32_RS05900	COG2311	Membrane
C4K32_RS05920	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS05925	COG1177	transmembrane transport
C4K32_RS05930	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K32_RS05935	COG3842	ATPase activity
C4K32_RS05940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K32_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS05950	COG0583	DNA-binding transcription factor activity
C4K32_RS05960	COG0840	transmembrane signaling receptor activity
C4K32_RS05970	COG0457	Tetratricopeptide repeat
C4K32_RS05970	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K32_RS05985	COG2201	protein-glutamate methylesterase activity
C4K32_RS05990	COG2203	Gaf domain
C4K32_RS05990	COG3706	GGDEF domain
C4K32_RS05990	COG5001	Diguanylate cyclase
C4K32_RS05990	COG4251	negative regulation of phosphorylation
C4K32_RS06000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4K32_RS06020	COG1073	alpha beta
C4K32_RS06045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4K32_RS06050	COG0563	adenylate kinase activity
C4K32_RS06065	COG1801	Protein of unknown function DUF72
C4K32_RS06080	COG0742	ribosomal rna small subunit methyltransferase
C4K32_RS06090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS06110	COG2937	Belongs to the GPAT DAPAT family
C4K32_RS06125	COG2226	methyltransferase
C4K32_RS06130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K32_RS06140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4K32_RS06150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K32_RS06155	COG2171	N-acyltransferase activity
C4K32_RS06160	COG1393	Belongs to the ArsC family
C4K32_RS06165	COG0025	NhaP-type Na H and K H
C4K32_RS06170	COG0436	Aminotransferase
C4K32_RS06175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4K32_RS06180	COG0024	Methionine aminopeptidase
C4K32_RS06185	COG0052	Belongs to the universal ribosomal protein uS2 family
C4K32_RS06190	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4K32_RS06195	COG0528	UMP kinase activity
C4K32_RS06200	COG0233	cytoplasmic translational termination
C4K32_RS06205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4K32_RS06215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4K32_RS06235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K32_RS06240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K32_RS06245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K32_RS06250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K32_RS06255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4K32_RS06260	COG0587	DNA-directed DNA polymerase activity
C4K32_RS06265	COG0825	malonyl-CoA metabolic process
C4K32_RS06270	COG0037	tRNA processing
C4K32_RS06275	COG0504	CTP synthase activity
C4K32_RS06280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4K32_RS06285	COG0148	phosphopyruvate hydratase activity
C4K32_RS06295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4K32_RS06305	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4K32_RS06310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4K32_RS06315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4K32_RS06320	COG0585	pseudouridine synthase activity
C4K32_RS06325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K32_RS06330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4K32_RS06350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4K32_RS06375	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K32_RS06485	COG4386	tail sheath protein
C4K32_RS06520	COG4381	Mu-like prophage protein gp46
C4K32_RS06570	COG3179	chitinase
C4K32_RS06580	COG1546	Belongs to the CinA family
C4K32_RS06585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4K32_RS06590	COG2137	regulation of response to DNA damage stimulus
C4K32_RS06610	COG3148	PFAM DTW domain containing protein
C4K32_RS06625	COG0583	DNA-binding transcription factor activity
C4K32_RS06645	COG4807	Protein conserved in bacteria
C4K32_RS06650	COG1187	pseudouridine synthase activity
C4K32_RS06660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K32_RS06670	COG3158	transport of potassium into the cell
C4K32_RS06680	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C4K32_RS06680	COG0392	lysyltransferase activity
C4K32_RS06695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4K32_RS06705	COG0442	prolyl-tRNA aminoacylation
C4K32_RS06730	COG1278	Cold shock
C4K32_RS06735	COG0717	Belongs to the dCTP deaminase family
C4K32_RS06760	COG4215	(ABC) transporter
C4K32_RS06770	COG2366	antibiotic biosynthetic process
C4K32_RS06775	COG0625	glutathione transferase activity
C4K32_RS06785	COG0653	protein targeting
C4K32_RS06795	COG3012	SEC-C Motif Domain Protein
C4K32_RS06830	COG1199	ATP-dependent helicase activity
C4K32_RS06845	COG2885	chlorophyll binding
C4K32_RS06850	COG0259	pyridoxamine-phosphate oxidase activity
C4K32_RS06865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K32_RS06875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4K32_RS06890	COG0583	DNA-binding transcription factor activity
C4K32_RS06905	COG3220	belongs to the UPF0276 family
C4K32_RS06950	COG2084	Dehydrogenase
C4K32_RS06960	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4K32_RS06965	COG2271	Major facilitator Superfamily
C4K32_RS06970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K32_RS06980	COG0306	phosphate transporter
C4K32_RS06990	COG1414	Transcriptional regulator
C4K32_RS06995	COG2814	Major facilitator Superfamily
C4K32_RS07000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K32_RS07005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4K32_RS07010	COG0183	Belongs to the thiolase family
C4K32_RS07015	COG3485	protocatechuate 3,4-dioxygenase
C4K32_RS07020	COG3485	protocatechuate 3,4-dioxygenase
C4K32_RS07025	COG0477	Major facilitator Superfamily
C4K32_RS07035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K32_RS07040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K32_RS07060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS07075	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS07080	COG2814	Major facilitator Superfamily
C4K32_RS07120	COG1473	amidohydrolase
C4K32_RS07130	COG0154	amidase activity
C4K32_RS07155	COG1704	LemA family
C4K32_RS07160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4K32_RS07175	COG0697	spore germination
C4K32_RS07180	COG0693	protein deglycase activity
C4K32_RS07195	COG2188	Transcriptional regulator
C4K32_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS07240	COG1629	transport
C4K32_RS07250	COG1595	DNA-templated transcription, initiation
C4K32_RS07255	COG3422	double-strand break repair
C4K32_RS07260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K32_RS07265	COG0235	Class ii aldolase
C4K32_RS07270	COG1396	sequence-specific DNA binding
C4K32_RS07280	COG1454	alcohol dehydrogenase
C4K32_RS07365	COG3938	Belongs to the proline racemase family
C4K32_RS07370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K32_RS07375	COG0531	amino acid
C4K32_RS07385	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4K32_RS07410	COG0583	DNA-binding transcription factor activity
C4K32_RS07415	COG5001	Diguanylate cyclase
C4K32_RS07445	COG2267	carboxylic ester hydrolase activity
C4K32_RS07475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4K32_RS07525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4K32_RS07555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K32_RS07565	COG0425	Belongs to the sulfur carrier protein TusA family
C4K32_RS07575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4K32_RS07590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K32_RS07595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4K32_RS07600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K32_RS07605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4K32_RS07625	COG2197	response regulator
C4K32_RS07635	COG3121	Chaperone
C4K32_RS07640	COG3188	usher protein
C4K32_RS07645	COG3121	Chaperone
C4K32_RS07655	COG3210	domain, Protein
C4K32_RS07685	COG2807	transmembrane transport
C4K32_RS07690	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4K32_RS07700	COG0583	DNA-binding transcription factor activity
C4K32_RS07710	COG2194	sulfuric ester hydrolase activity
C4K32_RS07725	COG3100	YcgL domain-containing protein
C4K32_RS07740	COG2983	Belongs to the UPF0260 family
C4K32_RS07790	COG0121	glutamine amidotransferase
C4K32_RS07800	COG0583	DNA-binding transcription factor activity
C4K32_RS07805	COG2814	Major facilitator Superfamily
C4K32_RS07810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K32_RS07815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K32_RS07820	COG1984	allophanate hydrolase subunit 2
C4K32_RS07830	COG0542	response to heat
C4K32_RS07840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K32_RS07870	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4K32_RS07875	COG1643	Atp-dependent helicase
C4K32_RS07885	COG1595	DNA-templated transcription, initiation
C4K32_RS07915	COG0814	amino acid
C4K32_RS07950	COG0477	Major facilitator Superfamily
C4K32_RS07955	COG0583	DNA-binding transcription factor activity
C4K32_RS07965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4K32_RS07970	COG1132	(ABC) transporter
C4K32_RS07995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K32_RS08005	COG0668	transmembrane transport
C4K32_RS08010	COG0513	Belongs to the DEAD box helicase family
C4K32_RS08060	COG0697	spore germination
C4K32_RS08070	COG0583	DNA-binding transcription factor activity
C4K32_RS08080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K32_RS08085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K32_RS08115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS08135	COG5002	protein histidine kinase activity
C4K32_RS08135	COG5001	Diguanylate cyclase
C4K32_RS08145	COG2832	Protein of unknown function (DUF454)
C4K32_RS08170	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4K32_RS08185	COG2207	Transcriptional regulator
C4K32_RS08210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4K32_RS08230	COG0745	RESPONSE REGULATOR receiver
C4K32_RS08240	COG2350	Protein conserved in bacteria
C4K32_RS08245	COG2917	probably involved in intracellular septation
C4K32_RS08250	COG0613	PHP domain protein
C4K32_RS08255	COG0009	L-threonylcarbamoyladenylate synthase
C4K32_RS08265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4K32_RS08285	COG1113	amino acid transport
C4K32_RS08310	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4K32_RS08325	COG4786	Flagellar basal body rod
C4K32_RS08335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4K32_RS08340	COG1706	bacterial-type flagellum-dependent cell motility
C4K32_RS08350	COG1256	bacterial-type flagellum assembly
C4K32_RS08360	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS08360	COG1216	Glycosyl transferase, family 2
C4K32_RS08365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K32_RS08400	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS08400	COG1216	Glycosyl transferase, family 2
C4K32_RS08405	COG1086	Polysaccharide biosynthesis protein
C4K32_RS08410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K32_RS08415	COG1083	cytidylyl-transferase
C4K32_RS08425	COG2089	acid synthase
C4K32_RS08430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4K32_RS08455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4K32_RS08485	COG1677	Flagellar hook-basal body complex protein FliE
C4K32_RS08520	COG0745	RESPONSE REGULATOR receiver
C4K32_RS08600	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4K32_RS08605	COG2198	Histidine kinase
C4K32_RS08605	COG0784	Response regulator, receiver
C4K32_RS08605	COG0643	Histidine kinase
C4K32_RS08610	COG2201	protein-glutamate methylesterase activity
C4K32_RS08615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4K32_RS08625	COG1192	Involved in chromosome partitioning
C4K32_RS08635	COG0835	chemotaxis
C4K32_RS08655	COG4133	protoheme IX ABC transporter activity
C4K32_RS08675	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4K32_RS08680	COG1138	Cytochrome C-type biogenesis protein
C4K32_RS08690	COG3088	subunit of a heme lyase
C4K32_RS08710	COG0583	DNA-binding transcription factor activity
C4K32_RS08715	COG2814	Major facilitator Superfamily
C4K32_RS08735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K32_RS08740	COG4413	Urea transporter
C4K32_RS08745	COG0469	pyruvate kinase activity
C4K32_RS08755	COG2084	Dehydrogenase
C4K32_RS08760	COG3622	Belongs to the hyi family
C4K32_RS08765	COG3960	tartronate-semialdehyde synthase activity
C4K32_RS08775	COG1309	transcriptional regulator
C4K32_RS08780	COG2354	Protein conserved in bacteria
C4K32_RS08785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K32_RS08800	COG1834	amidinotransferase
C4K32_RS08810	COG2192	nodulation
C4K32_RS08815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K32_RS08840	COG2853	Lipoprotein
C4K32_RS08860	COG2113	Glycine betaine
C4K32_RS08865	COG3162	membrane
C4K32_RS08870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K32_RS08880	COG2009	succinate dehydrogenase
C4K32_RS08885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4K32_RS08890	COG1053	succinate dehydrogenase
C4K32_RS08910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K32_RS08915	COG0045	succinate-CoA ligase (ADP-forming) activity
C4K32_RS08955	COG0326	Molecular chaperone. Has ATPase activity
C4K32_RS08965	COG0626	cystathionine gamma-synthase activity
C4K32_RS08975	COG1741	Belongs to the pirin family
C4K32_RS09000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K32_RS09015	COG4771	TonB-dependent receptor
C4K32_RS09020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4K32_RS09030	COG2062	phosphohistidine phosphatase, SixA
C4K32_RS09035	COG1022	Amp-dependent synthetase and ligase
C4K32_RS09055	COG0625	glutathione transferase activity
C4K32_RS09065	COG0628	permease
C4K32_RS09085	COG0284	orotidine-5'-phosphate decarboxylase activity
C4K32_RS09090	COG2130	NADP-dependent
C4K32_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS09100	COG0840	transmembrane signaling receptor activity
C4K32_RS09130	COG2814	Major facilitator Superfamily
C4K32_RS09140	COG2205	protein histidine kinase activity
C4K32_RS09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS09160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K32_RS09175	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS09185	COG0625	glutathione transferase activity
C4K32_RS09190	COG1131	(ABC) transporter
C4K32_RS09195	COG0842	Transport permease protein
C4K32_RS09210	COG0811	peptide transport
C4K32_RS09215	COG0848	biopolymer transport protein
C4K32_RS09220	COG1663	tetraacyldisaccharide 4'-kinase activity
C4K32_RS09225	COG2835	tetraacyldisaccharide 4'-kinase activity
C4K32_RS09230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K32_RS09235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K32_RS09240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4K32_RS09250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K32_RS09255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4K32_RS09255	COG3608	succinylglutamate desuccinylase aspartoacylase
C4K32_RS09265	COG1530	ribonuclease E activity
C4K32_RS09275	COG0546	phosphoglycolate phosphatase activity
C4K32_RS09280	COG0616	signal peptide processing
C4K32_RS09280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K32_RS09285	COG0424	maF-like protein
C4K32_RS09295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4K32_RS09300	COG0416	fatty acid biosynthetic process
C4K32_RS09315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS09320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K32_RS09330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4K32_RS09335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4K32_RS09345	COG0084	hydrolase, TatD family'
C4K32_RS09360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K32_RS09375	COG2188	Transcriptional regulator
C4K32_RS09380	COG1397	ADP-ribosylglycohydrolase
C4K32_RS09390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K32_RS09405	COG1418	mRNA catabolic process
C4K32_RS09415	COG1064	alcohol dehydrogenase
C4K32_RS09420	COG2207	Transcriptional regulator
C4K32_RS09450	COG2885	chlorophyll binding
C4K32_RS09455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K32_RS09490	COG0183	Belongs to the thiolase family
C4K32_RS09495	COG1024	Enoyl-CoA hydratase
C4K32_RS09495	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS09500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K32_RS09500	COG0519	Catalyzes the synthesis of GMP from XMP
C4K32_RS09505	COG0583	DNA-binding transcription factor activity
C4K32_RS09515	COG0598	Magnesium transport protein CorA
C4K32_RS09520	COG0204	Acyl-transferase
C4K32_RS09570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K32_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS09580	COG0583	DNA-binding transcription factor activity
C4K32_RS09590	COG1953	Uracil, thiamine, allantoin
C4K32_RS09600	COG0560	Phosphoserine phosphatase
C4K32_RS09620	COG4067	protein conserved in archaea
C4K32_RS09620	COG0189	ligase activity
C4K32_RS09625	COG1802	Transcriptional regulator
C4K32_RS09635	COG0372	Belongs to the citrate synthase family
C4K32_RS09650	COG2079	MmgE PrpD family protein
C4K32_RS09655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4K32_RS09670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K32_RS09685	COG0668	transmembrane transport
C4K32_RS09695	COG2885	chlorophyll binding
C4K32_RS09695	COG3047	cAMP biosynthetic process
C4K32_RS09700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K32_RS09705	COG0243	molybdopterin cofactor binding
C4K32_RS09710	COG2146	nitrite reductase [NAD(P)H] activity
C4K32_RS09715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K32_RS09720	COG0515	serine threonine protein kinase
C4K32_RS09720	COG2815	serine threonine protein kinase
C4K32_RS09725	COG2223	nitrite transmembrane transporter activity
C4K32_RS09730	COG3707	response regulator
C4K32_RS09735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS09735	COG1116	anion transmembrane transporter activity
C4K32_RS09740	COG0167	dihydroorotate dehydrogenase activity
C4K32_RS09745	COG3130	regulation of translation
C4K32_RS09750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K32_RS09750	COG0116	Belongs to the methyltransferase superfamily
C4K32_RS09760	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K32_RS09765	COG3171	Protein conserved in bacteria
C4K32_RS09770	COG3135	benzoate transporter
C4K32_RS09775	COG1802	Transcriptional regulator
C4K32_RS09780	COG0402	S-adenosylhomocysteine deaminase activity
C4K32_RS09810	COG3115	cell septum assembly
C4K32_RS09815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K32_RS09870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4K32_RS09875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4K32_RS09880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4K32_RS09885	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS09890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K32_RS09895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K32_RS09915	COG2217	Heavy metal translocating P-type atpase
C4K32_RS09925	COG0348	domain, Protein
C4K32_RS09940	COG2010	Cytochrome c
C4K32_RS09955	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K32_RS09960	COG2010	Cytochrome c
C4K32_RS09975	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K32_RS09985	COG0840	transmembrane signaling receptor activity
C4K32_RS10000	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4K32_RS10005	COG0425	Belongs to the sulfur carrier protein TusA family
C4K32_RS10015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K32_RS10025	COG1132	(ABC) transporter
C4K32_RS10030	COG0741	lytic transglycosylase activity
C4K32_RS10035	COG0488	(ABC) transporter
C4K32_RS10040	COG0589	response to stress
C4K32_RS10055	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS10055	COG1024	Enoyl-CoA hydratase
C4K32_RS10060	COG0183	Belongs to the thiolase family
C4K32_RS10110	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K32_RS10115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K32_RS10125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4K32_RS10140	COG1477	protein flavinylation
C4K32_RS10145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K32_RS10150	COG0584	glycerophosphoryl diester phosphodiesterase
C4K32_RS10160	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K32_RS10165	COG1136	(ABC) transporter
C4K32_RS10170	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K32_RS10190	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K32_RS10190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K32_RS10200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K32_RS10205	COG2853	Lipoprotein
C4K32_RS10215	COG2204	response regulator
C4K32_RS10225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4K32_RS10230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K32_RS10235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K32_RS10240	COG0583	DNA-binding transcription factor activity
C4K32_RS10250	COG3706	GGDEF domain
C4K32_RS10250	COG2203	Gaf domain
C4K32_RS10250	COG4251	negative regulation of phosphorylation
C4K32_RS10250	COG5001	Diguanylate cyclase
C4K32_RS10270	COG2233	PERMEase
C4K32_RS10300	COG0556	nucleotide-excision repair
C4K32_RS10305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K32_RS10335	COG0596	Alpha beta hydrolase
C4K32_RS10345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K32_RS10360	COG2214	Heat shock protein DnaJ domain protein
C4K32_RS10365	COG0443	Heat shock 70 kDa protein
C4K32_RS10380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4K32_RS10385	COG0066	3-isopropylmalate dehydratase activity
C4K32_RS10390	COG0473	3-isopropylmalate dehydrogenase activity
C4K32_RS10420	COG0135	phosphoribosylanthranilate isomerase activity
C4K32_RS10425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4K32_RS10430	COG0285	dihydrofolate synthase activity
C4K32_RS10435	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K32_RS10440	COG1286	toxin biosynthetic process
C4K32_RS10475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS10510	COG3397	chitin binding
C4K32_RS10515	COG3469	chitinase activity
C4K32_RS10530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K32_RS10560	COG1879	ABC-type sugar transport system periplasmic component
C4K32_RS10565	COG1129	ABC transporter
C4K32_RS10570	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K32_RS10575	COG1609	Transcriptional regulator
C4K32_RS10580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K32_RS10585	COG1869	D-ribose catabolic process
C4K32_RS10610	COG1278	Cold shock
C4K32_RS10620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K32_RS10625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4K32_RS10630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4K32_RS10635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4K32_RS10640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4K32_RS10645	COG0072	phenylalanine-tRNA ligase activity
C4K32_RS10650	COG0776	regulation of translation
C4K32_RS10680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K32_RS10680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS10680	COG3321	synthase
C4K32_RS10680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K32_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS10685	COG4221	oxidoreductase activity
C4K32_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS10685	COG3321	synthase
C4K32_RS10685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K32_RS10690	COG3321	synthase
C4K32_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS10690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K32_RS10690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K32_RS10690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS10695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS10695	COG3321	synthase
C4K32_RS10695	COG4221	oxidoreductase activity
C4K32_RS10695	COG0300	oxidoreductase activity
C4K32_RS10700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K32_RS10705	COG0076	glutamate decarboxylase activity
C4K32_RS10710	COG2091	lysine biosynthetic process via aminoadipic acid
C4K32_RS10740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K32_RS10775	COG1309	transcriptional regulator
C4K32_RS10780	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS10800	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS10805	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS10810	COG4191	Histidine kinase
C4K32_RS10815	COG4566	intracellular signal transduction
C4K32_RS10825	COG1598	PFAM Uncharacterised protein family UPF0150
C4K32_RS10840	COG0515	serine threonine protein kinase
C4K32_RS10840	COG2815	serine threonine protein kinase
C4K32_RS10855	COG2826	transposase and inactivated derivatives, IS30 family
C4K32_RS10870	COG0450	alkyl hydroperoxide reductase
C4K32_RS10900	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K32_RS10905	COG3657	addiction module killer protein
C4K32_RS10910	COG5383	Protein conserved in bacteria
C4K32_RS10915	COG3706	GGDEF domain
C4K32_RS10940	COG0531	amino acid
C4K32_RS10965	COG0583	DNA-binding transcription factor activity
C4K32_RS11045	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4K32_RS11050	COG0247	lactate metabolic process
C4K32_RS11055	COG0277	FAD linked oxidase domain protein
C4K32_RS11060	COG0277	FAD linked oxidase domain protein
C4K32_RS11065	COG2186	Transcriptional regulator
C4K32_RS11090	COG1063	alcohol dehydrogenase
C4K32_RS11105	COG0709	Synthesizes selenophosphate from selenide and ATP
C4K32_RS11110	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4K32_RS11115	COG0701	Predicted permease
C4K32_RS11120	COG1414	Transcriptional regulator
C4K32_RS11125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS11130	COG0765	amino acid transport
C4K32_RS11135	COG1126	abc transporter atp-binding protein
C4K32_RS11140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS11150	COG0625	glutathione transferase activity
C4K32_RS11155	COG0384	phenazine biosynthesis protein PhzF
C4K32_RS11170	COG0248	Ppx GppA phosphatase
C4K32_RS11200	COG0019	diaminopimelate decarboxylase activity
C4K32_RS11235	COG0071	Belongs to the small heat shock protein (HSP20) family
C4K32_RS11240	COG0113	porphobilinogen synthase activity
C4K32_RS11280	COG4650	regulator
C4K32_RS11290	COG1690	Belongs to the RtcB family
C4K32_RS11300	COG3541	Predicted nucleotidyltransferase
C4K32_RS11305	COG0430	RNA-3'-phosphate cyclase activity
C4K32_RS11335	COG0583	DNA-binding transcription factor activity
C4K32_RS11360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K32_RS11365	COG0583	DNA-binding transcription factor activity
C4K32_RS11370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K32_RS11380	COG3180	Ammonia monooxygenase
C4K32_RS11385	COG0583	DNA-binding transcription factor activity
C4K32_RS11395	COG3609	addiction module antidote protein, CC2985 family
C4K32_RS11400	COG0517	IMP dehydrogenase activity
C4K32_RS11420	COG1177	transmembrane transport
C4K32_RS11425	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K32_RS11430	COG3842	ATPase activity
C4K32_RS11435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K32_RS11440	COG0174	glutamine synthetase
C4K32_RS11445	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS11450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS11455	COG1917	Cupin 2, conserved barrel domain protein
C4K32_RS11455	COG1396	sequence-specific DNA binding
C4K32_RS11495	COG1595	DNA-templated transcription, initiation
C4K32_RS11500	COG3712	iron ion homeostasis
C4K32_RS11505	COG4772	TonB-dependent receptor
C4K32_RS11510	COG0583	DNA-binding transcription factor activity
C4K32_RS11515	COG2814	Major facilitator Superfamily
C4K32_RS11520	COG2384	SAM-dependent methyltransferase
C4K32_RS11525	COG1944	ATP diphosphatase activity
C4K32_RS11585	COG2223	nitrite transmembrane transporter activity
C4K32_RS11600	COG0697	spore germination
C4K32_RS11605	COG0583	DNA-binding transcription factor activity
C4K32_RS11615	COG0697	spore germination
C4K32_RS11620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K32_RS11630	COG0659	secondary active sulfate transmembrane transporter activity
C4K32_RS11640	COG1999	signal sequence binding
C4K32_RS11655	COG0583	DNA-binding transcription factor activity
C4K32_RS11660	COG3048	D-serine ammonia-lyase activity
C4K32_RS11665	COG2610	gluconate transmembrane transporter activity
C4K32_RS11670	COG0251	oxidation-reduction process
C4K32_RS11680	COG0688	phosphatidylethanolamine metabolic process
C4K32_RS11695	COG2207	Transcriptional regulator
C4K32_RS11695	COG1917	Cupin 2, conserved barrel domain protein
C4K32_RS11715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K32_RS11745	COG0826	peptidase U32
C4K32_RS11765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS11770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS11780	COG2207	Transcriptional regulator
C4K32_RS11835	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K32_RS11845	COG1611	Belongs to the LOG family
C4K32_RS11860	COG2204	response regulator
C4K32_RS11865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4K32_RS11875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K32_RS11895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS11900	COG0174	glutamine synthetase
C4K32_RS11915	COG1335	isochorismatase
C4K32_RS11920	COG3224	Antibiotic biosynthesis monooxygenase
C4K32_RS11935	COG0417	DNA replication proofreading
C4K32_RS11950	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K32_RS11965	COG0477	Major facilitator Superfamily
C4K32_RS11985	COG4319	ketosteroid isomerase
C4K32_RS11990	COG4335	DNA alkylation repair
C4K32_RS12000	COG0501	Belongs to the peptidase M48B family
C4K32_RS12005	COG1704	LemA family
C4K32_RS12010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K32_RS12060	COG2267	carboxylic ester hydrolase activity
C4K32_RS12075	COG0640	Transcriptional regulator
C4K32_RS12090	COG2308	Evidence 4 Homologs of previously reported genes of
C4K32_RS12100	COG1305	Transglutaminase-like
C4K32_RS12105	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K32_RS12110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4K32_RS12115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K32_RS12125	COG0022	dehydrogenase e1 component
C4K32_RS12130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K32_RS12135	COG1522	sequence-specific DNA binding
C4K32_RS12145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K32_RS12165	COG2372	response to copper ion
C4K32_RS12175	COG1309	transcriptional regulator
C4K32_RS12185	COG0493	'glutamate synthase
C4K32_RS12195	COG1953	Uracil, thiamine, allantoin
C4K32_RS12205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS12210	COG4175	Glycine betaine
C4K32_RS12220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K32_RS12255	COG0495	leucyl-tRNA aminoacylation
C4K32_RS12300	COG1595	DNA-templated transcription, initiation
C4K32_RS12345	COG2391	methyltransferase activity
C4K32_RS12395	COG3237	CsbD-like
C4K32_RS12410	COG0745	RESPONSE REGULATOR receiver
C4K32_RS12425	COG3383	formate dehydrogenase (NAD+) activity
C4K32_RS12430	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K32_RS12435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS12475	COG3718	enzyme involved in inositol metabolism
C4K32_RS12490	COG3962	Belongs to the TPP enzyme family
C4K32_RS12495	COG0673	inositol 2-dehydrogenase activity
C4K32_RS12505	COG1082	Xylose isomerase domain protein TIM barrel
C4K32_RS12510	COG0673	inositol 2-dehydrogenase activity
C4K32_RS12525	COG1129	ABC transporter
C4K32_RS12530	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4K32_RS12540	COG0840	transmembrane signaling receptor activity
C4K32_RS12575	COG4774	siderophore transport
C4K32_RS12590	COG1320	monovalent cation:proton antiporter activity
C4K32_RS12595	COG2212	antiporter activity
C4K32_RS12605	COG0651	ATP synthesis coupled electron transport
C4K32_RS12610	COG1006	Multisubunit Na H antiporter MnhC subunit
C4K32_RS12615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4K32_RS12615	COG2111	Na H antiporter
C4K32_RS12680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K32_RS12685	COG0673	inositol 2-dehydrogenase activity
C4K32_RS12695	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS12705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K32_RS12710	COG1335	isochorismatase
C4K32_RS12725	COG3383	formate dehydrogenase (NAD+) activity
C4K32_RS12735	COG0814	amino acid
C4K32_RS12760	COG0589	response to stress
C4K32_RS12770	COG0745	RESPONSE REGULATOR receiver
C4K32_RS12775	COG2205	protein histidine kinase activity
C4K32_RS12790	COG3791	Glutathione-dependent formaldehyde-activating
C4K32_RS12805	COG0583	DNA-binding transcription factor activity
C4K32_RS12810	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4K32_RS12815	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS12820	COG2079	MmgE PrpD family protein
C4K32_RS12865	COG0431	NADPH-dependent FMN reductase
C4K32_RS12925	COG2271	Major facilitator Superfamily
C4K32_RS12930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K32_RS12970	COG1073	alpha beta
C4K32_RS13050	COG1522	sequence-specific DNA binding
C4K32_RS13055	COG0494	nUDIX hydrolase
C4K32_RS13070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS13075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS13095	COG0596	Alpha beta hydrolase
C4K32_RS13100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4K32_RS13105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4K32_RS13105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4K32_RS13115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K32_RS13125	COG2384	SAM-dependent methyltransferase
C4K32_RS13130	COG0789	Transcriptional regulator
C4K32_RS13135	COG1090	epimerase
C4K32_RS13150	COG3064	Membrane
C4K32_RS13205	COG2080	2 iron, 2 sulfur cluster binding
C4K32_RS13210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4K32_RS13215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K32_RS13220	COG1280	lysine exporter protein (LysE YggA)
C4K32_RS13255	COG1566	PFAM secretion protein HlyD family protein
C4K32_RS13265	COG2828	Protein conserved in bacteria
C4K32_RS13270	COG2207	Transcriptional regulator
C4K32_RS13285	COG3153	acetyltransferase
C4K32_RS13295	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K32_RS13295	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS13325	COG0833	amino acid
C4K32_RS13330	COG1024	Enoyl-CoA hydratase
C4K32_RS13335	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS13360	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K32_RS13365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4K32_RS13410	COG2084	Dehydrogenase
C4K32_RS13415	COG3395	kinase activity
C4K32_RS13420	COG0235	Class ii aldolase
C4K32_RS13425	COG2610	gluconate transmembrane transporter activity
C4K32_RS13430	COG3622	Belongs to the hyi family
C4K32_RS13440	COG1349	DNA-binding transcription factor activity
C4K32_RS13540	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS13555	COG2202	Pas domain
C4K32_RS13555	COG2200	EAL domain
C4K32_RS13555	COG2199	diguanylate cyclase activity
C4K32_RS13560	COG0833	amino acid
C4K32_RS13565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS13570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4K32_RS13585	COG0494	nUDIX hydrolase
C4K32_RS13595	COG3220	belongs to the UPF0276 family
C4K32_RS13605	COG2259	Doxx family
C4K32_RS13615	COG2205	protein histidine kinase activity
C4K32_RS13655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4K32_RS13660	COG1280	lysine exporter protein (LysE YggA)
C4K32_RS13675	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K32_RS13695	COG0754	glutathionylspermidine amidase activity
C4K32_RS13705	COG3766	membrane
C4K32_RS13725	COG1842	Phage shock protein A
C4K32_RS13765	COG0583	DNA-binding transcription factor activity
C4K32_RS13770	COG0300	oxidoreductase activity
C4K32_RS13805	COG4172	Belongs to the ABC transporter superfamily
C4K32_RS13810	COG4239	(ABC) transporter, permease
C4K32_RS13815	COG4174	ABC transporter (Permease)
C4K32_RS13820	COG4166	transmembrane transport
C4K32_RS13825	COG4166	transmembrane transport
C4K32_RS13830	COG1388	LysM domain
C4K32_RS13830	COG0741	lytic transglycosylase activity
C4K32_RS13835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K32_RS13845	COG0328	RNA-DNA hybrid ribonuclease activity
C4K32_RS13860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K32_RS13885	COG0431	NADPH-dependent FMN reductase
C4K32_RS13890	COG0640	Transcriptional regulator
C4K32_RS13905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4K32_RS13910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K32_RS13920	COG3139	Protein of unknown function (DUF1315)
C4K32_RS13930	COG0308	aminopeptidase N
C4K32_RS13935	COG0659	secondary active sulfate transmembrane transporter activity
C4K32_RS13955	COG2706	6-phosphogluconolactonase activity
C4K32_RS13985	COG0420	3'-5' exonuclease activity
C4K32_RS14040	COG0714	Associated with various cellular activities
C4K32_RS14045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K32_RS14050	COG0477	Major facilitator Superfamily
C4K32_RS14055	COG0579	oxidoreductase
C4K32_RS14060	COG2186	Transcriptional regulator
C4K32_RS14090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K32_RS14095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K32_RS14270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K32_RS14280	COG1247	-acetyltransferase
C4K32_RS14285	COG1794	racemase activity, acting on amino acids and derivatives
C4K32_RS14305	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K32_RS14315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K32_RS14350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS14355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS14360	COG1538	Outer membrane efflux protein
C4K32_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS14375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K32_RS14380	COG0348	domain, Protein
C4K32_RS14405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K32_RS14420	COG3568	Endonuclease Exonuclease Phosphatase
C4K32_RS14445	COG1640	4-alpha-glucanotransferase
C4K32_RS14450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K32_RS14455	COG0297	glycogen (starch) synthase activity
C4K32_RS14460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K32_RS14470	COG1238	metal cluster binding
C4K32_RS14510	COG0667	Aldo Keto reductase
C4K32_RS14515	COG0583	DNA-binding transcription factor activity
C4K32_RS14530	COG2366	antibiotic biosynthetic process
C4K32_RS14570	COG0583	DNA-binding transcription factor activity
C4K32_RS14585	COG0583	DNA-binding transcription factor activity
C4K32_RS14590	COG2066	Belongs to the glutaminase family
C4K32_RS14600	COG2233	PERMEase
C4K32_RS14610	COG0010	Belongs to the arginase family
C4K32_RS14625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K32_RS14660	COG2194	sulfuric ester hydrolase activity
C4K32_RS14665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4K32_RS14670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4K32_RS14675	COG0561	phosphatase activity
C4K32_RS14680	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K32_RS14685	COG2030	dehydratase
C4K32_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS14700	COG3162	membrane
C4K32_RS14705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K32_RS14710	COG2151	metal-sulfur cluster biosynthetic enzyme
C4K32_RS14715	COG3396	Phenylacetate-CoA oxygenase
C4K32_RS14720	COG3460	Phenylacetate-CoA oxygenase
C4K32_RS14725	COG3396	Phenylacetate-CoA oxygenase
C4K32_RS14735	COG0183	Belongs to the thiolase family
C4K32_RS14745	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS14750	COG1024	Enoyl-CoA hydratase
C4K32_RS14755	COG1024	Enoyl-CoA hydratase
C4K32_RS14765	COG3327	negative regulation of DNA-templated transcription, initiation
C4K32_RS14775	COG2204	response regulator
C4K32_RS14820	COG0840	transmembrane signaling receptor activity
C4K32_RS14825	COG1968	undecaprenyl-diphosphatase activity
C4K32_RS14845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K32_RS14860	COG0488	(ABC) transporter
C4K32_RS14875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4K32_RS14885	COG2133	pyrroloquinoline quinone binding
C4K32_RS14895	COG0189	ligase activity
C4K32_RS14900	COG0598	Magnesium transport protein CorA
C4K32_RS14905	COG0024	Methionine aminopeptidase
C4K32_RS14920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K32_RS14925	COG4574	serine-type endopeptidase inhibitor activity
C4K32_RS15005	COG0726	polysaccharide deacetylase
C4K32_RS15015	COG0463	Glycosyl transferase, family 2
C4K32_RS15075	COG1070	Carbohydrate kinase
C4K32_RS15095	COG1175	transmembrane transport
C4K32_RS15105	COG4774	siderophore transport
C4K32_RS15110	COG2207	Transcriptional regulator
C4K32_RS15115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K32_RS15125	COG0183	Belongs to the thiolase family
C4K32_RS15130	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS15135	COG1024	Enoyl-CoA hydratase
C4K32_RS15140	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS15145	COG1024	Enoyl-CoA hydratase
C4K32_RS15155	COG0463	Glycosyl transferase, family 2
C4K32_RS15175	COG2814	Major facilitator Superfamily
C4K32_RS15205	COG0765	amino acid transport
C4K32_RS15210	COG0165	Argininosuccinate lyase
C4K32_RS15235	COG2076	Multidrug Resistance protein
C4K32_RS15240	COG2076	Multidrug Resistance protein
C4K32_RS15245	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K32_RS15250	COG0726	polysaccharide deacetylase
C4K32_RS15255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K32_RS15255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K32_RS15260	COG0463	Glycosyl transferase, family 2
C4K32_RS15265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K32_RS15280	COG1131	(ABC) transporter
C4K32_RS15315	COG0765	amino acid transport
C4K32_RS15325	COG0405	Gamma-glutamyltransferase
C4K32_RS15355	COG0589	response to stress
C4K32_RS15385	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS15405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS15410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS15425	COG1024	Enoyl-CoA hydratase
C4K32_RS15425	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS15460	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS15470	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS15475	COG3321	synthase
C4K32_RS15475	COG0300	oxidoreductase activity
C4K32_RS15475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K32_RS15475	COG4221	oxidoreductase activity
C4K32_RS15480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS15485	COG1231	oxidoreductase activity
C4K32_RS15500	COG2863	cytochrome
C4K32_RS15520	COG0251	oxidation-reduction process
C4K32_RS15530	COG0745	RESPONSE REGULATOR receiver
C4K32_RS15565	COG3209	COG3209 Rhs family protein
C4K32_RS15585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K32_RS15590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K32_RS15615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K32_RS15620	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K32_RS15635	COG4608	Belongs to the ABC transporter superfamily
C4K32_RS15640	COG0444	Belongs to the ABC transporter superfamily
C4K32_RS15645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K32_RS15650	COG0601	transmembrane transport
C4K32_RS15655	COG0747	negative chemotaxis
C4K32_RS15660	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4K32_RS15675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K32_RS15680	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4K32_RS15690	COG3540	Alkaline phosphatase
C4K32_RS15715	COG0811	peptide transport
C4K32_RS15725	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K32_RS15740	COG2084	Dehydrogenase
C4K32_RS15750	COG2130	NADP-dependent
C4K32_RS15755	COG1309	transcriptional regulator
C4K32_RS15760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS15765	COG1116	anion transmembrane transporter activity
C4K32_RS15770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS15775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS15785	COG0583	DNA-binding transcription factor activity
C4K32_RS15795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K32_RS15805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS15815	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS15820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K32_RS15840	COG4206	TonB-dependent receptor
C4K32_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS15865	COG0583	DNA-binding transcription factor activity
C4K32_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS15880	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C4K32_RS15900	COG1196	nuclear chromosome segregation
C4K32_RS15900	COG3264	Mechanosensitive ion channel
C4K32_RS15905	COG3706	GGDEF domain
C4K32_RS15910	COG0583	DNA-binding transcription factor activity
C4K32_RS15915	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS15955	COG0247	lactate metabolic process
C4K32_RS15955	COG0277	FAD linked oxidase domain protein
C4K32_RS15960	COG0583	DNA-binding transcription factor activity
C4K32_RS15975	COG4104	PAAR repeat-containing protein
C4K32_RS16010	COG2146	nitrite reductase [NAD(P)H] activity
C4K32_RS16010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K32_RS16015	COG2146	nitrite reductase [NAD(P)H] activity
C4K32_RS16015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K32_RS16020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K32_RS16030	COG1120	ATPase activity
C4K32_RS16035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K32_RS16040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K32_RS16045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K32_RS16050	COG4264	IucA IucC family
C4K32_RS16060	COG4264	IucA IucC family
C4K32_RS16065	COG2814	Major facilitator Superfamily
C4K32_RS16070	COG0019	diaminopimelate decarboxylase activity
C4K32_RS16075	COG4264	IucA IucC family
C4K32_RS16080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K32_RS16085	COG4774	siderophore transport
C4K32_RS16090	COG3712	iron ion homeostasis
C4K32_RS16095	COG1595	DNA-templated transcription, initiation
C4K32_RS16115	COG0174	glutamine synthetase
C4K32_RS16125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS16135	COG2200	EAL domain
C4K32_RS16150	COG3851	Histidine kinase
C4K32_RS16160	COG2205	protein histidine kinase activity
C4K32_RS16160	COG0784	Response regulator, receiver
C4K32_RS16200	COG0589	response to stress
C4K32_RS16205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS16210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS16215	COG1116	anion transmembrane transporter activity
C4K32_RS16230	COG1917	Cupin 2, conserved barrel domain protein
C4K32_RS16230	COG4977	sequence-specific DNA binding
C4K32_RS16235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS16245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS16250	COG1116	anion transmembrane transporter activity
C4K32_RS16270	COG0656	L-ascorbic acid biosynthetic process
C4K32_RS16275	COG2205	protein histidine kinase activity
C4K32_RS16275	COG0784	Response regulator, receiver
C4K32_RS16280	COG3300	MHYT domain
C4K32_RS16280	COG5001	Diguanylate cyclase
C4K32_RS16290	COG2197	response regulator
C4K32_RS16310	COG1199	ATP-dependent helicase activity
C4K32_RS16330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K32_RS16335	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K32_RS16400	COG0531	amino acid
C4K32_RS16415	COG2909	trisaccharide binding
C4K32_RS16425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K32_RS16430	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS16445	COG5295	Hep Hag repeat protein
C4K32_RS16505	COG2200	EAL domain
C4K32_RS16505	COG2199	diguanylate cyclase activity
C4K32_RS16505	COG2203	Gaf domain
C4K32_RS16510	COG2205	protein histidine kinase activity
C4K32_RS16510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS16515	COG2197	response regulator
C4K32_RS16535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS16550	COG0210	DNA helicase
C4K32_RS16565	COG0604	alcohol dehydrogenase
C4K32_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS16565	COG3321	synthase
C4K32_RS16580	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS16595	COG3469	chitinase activity
C4K32_RS16600	COG3397	chitin binding
C4K32_RS16605	COG0583	DNA-binding transcription factor activity
C4K32_RS16625	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS16645	COG2072	flavoprotein involved in K transport
C4K32_RS16650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS16655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS16660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS16675	COG1566	PFAM secretion protein HlyD family protein
C4K32_RS16700	COG2205	protein histidine kinase activity
C4K32_RS16700	COG2198	Histidine kinase
C4K32_RS16700	COG0784	Response regulator, receiver
C4K32_RS16710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K32_RS16715	COG0784	Response regulator, receiver
C4K32_RS16715	COG2198	Histidine kinase
C4K32_RS16715	COG2205	protein histidine kinase activity
C4K32_RS16735	COG0672	)-iron permease
C4K32_RS16740	COG2822	iron ion transport
C4K32_RS16750	COG2822	iron ion transport
C4K32_RS16755	COG2814	Major facilitator Superfamily
C4K32_RS16760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K32_RS16775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS16790	COG2816	NAD+ diphosphatase activity
C4K32_RS16795	COG1024	Enoyl-CoA hydratase
C4K32_RS16810	COG1335	isochorismatase
C4K32_RS16815	COG2205	protein histidine kinase activity
C4K32_RS16820	COG0745	RESPONSE REGULATOR receiver
C4K32_RS16825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS16865	COG1609	Transcriptional regulator
C4K32_RS16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K32_RS16940	COG2814	Major facilitator Superfamily
C4K32_RS16945	COG1063	alcohol dehydrogenase
C4K32_RS16965	COG0456	acetyltransferase
C4K32_RS16965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4K32_RS16990	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS16995	COG3384	dioxygenase
C4K32_RS17005	COG2271	Major facilitator Superfamily
C4K32_RS17010	COG3971	2-oxopent-4-enoate hydratase activity
C4K32_RS17020	COG1929	Belongs to the glycerate kinase type-1 family
C4K32_RS17025	COG3835	regulator
C4K32_RS17030	COG2271	Major facilitator Superfamily
C4K32_RS17035	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS17045	COG0583	DNA-binding transcription factor activity
C4K32_RS17050	COG0667	Aldo Keto reductase
C4K32_RS17060	COG1846	Transcriptional regulator
C4K32_RS17070	COG0697	spore germination
C4K32_RS17075	COG0583	DNA-binding transcription factor activity
C4K32_RS17080	COG2200	EAL domain
C4K32_RS17145	COG3258	Cytochrome c
C4K32_RS17150	COG2863	cytochrome
C4K32_RS17170	COG3145	DNA-N1-methyladenine dioxygenase activity
C4K32_RS17175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K32_RS17175	COG2169	Transcriptional regulator
C4K32_RS17185	COG0604	alcohol dehydrogenase
C4K32_RS17205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4K32_RS17210	COG0488	(ABC) transporter
C4K32_RS17220	COG0393	Putative heavy-metal-binding
C4K32_RS17325	COG0583	DNA-binding transcription factor activity
C4K32_RS17330	COG0583	DNA-binding transcription factor activity
C4K32_RS17335	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K32_RS17345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS17355	COG2205	protein histidine kinase activity
C4K32_RS17360	COG0745	RESPONSE REGULATOR receiver
C4K32_RS17370	COG0300	oxidoreductase activity
C4K32_RS17380	COG0583	DNA-binding transcription factor activity
C4K32_RS17385	COG1309	transcriptional regulator
C4K32_RS17410	COG0475	glutathione-regulated potassium exporter activity
C4K32_RS17415	COG1024	Enoyl-CoA hydratase
C4K32_RS17420	COG0515	serine threonine protein kinase
C4K32_RS17420	COG2815	serine threonine protein kinase
C4K32_RS17430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K32_RS17475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS17480	COG0789	Transcriptional regulator
C4K32_RS17535	COG2181	nitrate reductase activity
C4K32_RS17540	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4K32_RS17545	COG1140	nitrate reductase beta subunit
C4K32_RS17550	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C4K32_RS17555	COG2223	nitrite transmembrane transporter activity
C4K32_RS17565	COG3850	Histidine kinase
C4K32_RS17570	COG2197	response regulator
C4K32_RS17580	COG3154	lipid carrier protein
C4K32_RS17585	COG0826	peptidase U32
C4K32_RS17590	COG0826	peptidase U32
C4K32_RS17595	COG0303	'Molybdopterin
C4K32_RS17600	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K32_RS17615	COG3604	Transcriptional regulator
C4K32_RS17620	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C4K32_RS17635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K32_RS17650	COG3256	nitric oxide reductase
C4K32_RS17655	COG2010	Cytochrome c
C4K32_RS17665	COG1845	cytochrome c oxidase, subunit III
C4K32_RS17670	COG0714	Associated with various cellular activities
C4K32_RS17685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K32_RS17690	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K32_RS17710	COG3712	iron ion homeostasis
C4K32_RS17715	COG1595	DNA-templated transcription, initiation
C4K32_RS17720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS17730	COG0861	Integral membrane protein TerC family
C4K32_RS17780	COG2207	Transcriptional regulator
C4K32_RS17785	COG1064	alcohol dehydrogenase
C4K32_RS17825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K32_RS17830	COG1136	(ABC) transporter
C4K32_RS17830	COG0577	efflux transmembrane transporter activity
C4K32_RS17835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS17910	COG2197	response regulator
C4K32_RS17935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K32_RS17945	COG1136	(ABC) transporter
C4K32_RS17950	COG0515	serine threonine protein kinase
C4K32_RS17950	COG2815	serine threonine protein kinase
C4K32_RS18075	COG0583	DNA-binding transcription factor activity
C4K32_RS18080	COG1335	isochorismatase
C4K32_RS18085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K32_RS18105	COG4977	sequence-specific DNA binding
C4K32_RS18105	COG1917	Cupin 2, conserved barrel domain protein
C4K32_RS18135	COG1741	Belongs to the pirin family
C4K32_RS18160	COG1335	isochorismatase
C4K32_RS18170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS18170	COG2205	protein histidine kinase activity
C4K32_RS18180	COG2814	Major facilitator Superfamily
C4K32_RS18215	COG0251	oxidation-reduction process
C4K32_RS18225	COG2186	Transcriptional regulator
C4K32_RS18235	COG2814	Major facilitator Superfamily
C4K32_RS18240	COG2207	Transcriptional regulator
C4K32_RS18245	COG0300	oxidoreductase activity
C4K32_RS18290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS18300	COG1538	Outer membrane efflux protein
C4K32_RS18310	COG2197	response regulator
C4K32_RS18325	COG2205	protein histidine kinase activity
C4K32_RS18325	COG0784	Response regulator, receiver
C4K32_RS18350	COG0322	excinuclease ABC activity
C4K32_RS18355	COG2197	response regulator
C4K32_RS18375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K32_RS18380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4K32_RS18385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K32_RS18390	COG4166	transmembrane transport
C4K32_RS18395	COG4174	ABC transporter (Permease)
C4K32_RS18400	COG4239	(ABC) transporter, permease
C4K32_RS18405	COG4172	Belongs to the ABC transporter superfamily
C4K32_RS18410	COG3604	Transcriptional regulator
C4K32_RS18415	COG2610	gluconate transmembrane transporter activity
C4K32_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS18425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K32_RS18435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K32_RS18440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K32_RS18505	COG1607	acyl-coa hydrolase
C4K32_RS18510	COG0069	glutamate synthase activity
C4K32_RS18515	COG2026	Addiction module toxin, RelE StbE family
C4K32_RS18545	COG5001	Diguanylate cyclase
C4K32_RS18555	COG0583	DNA-binding transcription factor activity
C4K32_RS18560	COG3437	response regulator, receiver
C4K32_RS18560	COG3850	Histidine kinase
C4K32_RS18560	COG4999	Histidine kinase
C4K32_RS18560	COG2205	protein histidine kinase activity
C4K32_RS18565	COG1538	Outer membrane efflux protein
C4K32_RS18585	COG2274	protein secretion by the type I secretion system
C4K32_RS18590	COG1253	flavin adenine dinucleotide binding
C4K32_RS18595	COG2390	Transcriptional regulator
C4K32_RS18600	COG0698	ribose 5-phosphate isomerase
C4K32_RS18605	COG1129	ABC transporter
C4K32_RS18610	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K32_RS18615	COG1879	ABC-type sugar transport system periplasmic component
C4K32_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS18625	COG1063	alcohol dehydrogenase
C4K32_RS18630	COG2376	Dihydroxyacetone kinase
C4K32_RS18640	COG0583	DNA-binding transcription factor activity
C4K32_RS18660	COG0789	Transcriptional regulator
C4K32_RS18665	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K32_RS18665	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS18715	COG0316	Belongs to the HesB IscA family
C4K32_RS18715	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4K32_RS18735	COG1879	ABC-type sugar transport system periplasmic component
C4K32_RS18750	COG0616	signal peptide processing
C4K32_RS18765	COG4172	Belongs to the ABC transporter superfamily
C4K32_RS18770	COG4239	(ABC) transporter, permease
C4K32_RS18775	COG4174	ABC transporter (Permease)
C4K32_RS18780	COG4166	transmembrane transport
C4K32_RS18790	COG4206	TonB-dependent receptor
C4K32_RS18795	COG3712	iron ion homeostasis
C4K32_RS18800	COG1595	DNA-templated transcription, initiation
C4K32_RS18805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K32_RS18805	COG1024	Enoyl-CoA hydratase
C4K32_RS18825	COG3189	MarR family transcriptional regulator
C4K32_RS18830	COG2186	Transcriptional regulator
C4K32_RS18870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K32_RS18900	COG0784	Response regulator, receiver
C4K32_RS18900	COG4191	Histidine kinase
C4K32_RS18905	COG0587	DNA-directed DNA polymerase activity
C4K32_RS18920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K32_RS18940	COG2194	sulfuric ester hydrolase activity
C4K32_RS18960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS18975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4K32_RS18980	COG2188	Transcriptional regulator
C4K32_RS18985	COG0673	inositol 2-dehydrogenase activity
C4K32_RS19045	COG3447	MASE1 domain protein
C4K32_RS19045	COG5002	protein histidine kinase activity
C4K32_RS19045	COG5001	Diguanylate cyclase
C4K32_RS19055	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS19065	COG0303	'Molybdopterin
C4K32_RS19070	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K32_RS19075	COG0746	molybdenum cofactor guanylyltransferase activity
C4K32_RS19080	COG0583	DNA-binding transcription factor activity
C4K32_RS19095	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K32_RS19100	COG3781	membrane
C4K32_RS19105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K32_RS19115	COG1271	oxidase subunit
C4K32_RS19120	COG1294	oxidase, subunit
C4K32_RS19135	COG0697	spore germination
C4K32_RS19140	COG1522	sequence-specific DNA binding
C4K32_RS19165	COG0419	ATPase involved in DNA repair
C4K32_RS19195	COG3209	COG3209 Rhs family protein
C4K32_RS19390	COG2989	Protein conserved in bacteria
C4K32_RS19415	COG1858	cytochrome C peroxidase
C4K32_RS19440	COG0579	oxidoreductase
C4K32_RS19485	COG2920	part of a sulfur-relay system
C4K32_RS19490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K32_RS19495	COG0435	Glutathione S-transferase
C4K32_RS19500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K32_RS19500	COG1648	precorrin-2 dehydrogenase activity
C4K32_RS19505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4K32_RS19510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4K32_RS19515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4K32_RS19520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4K32_RS19525	COG1674	ftsk spoiiie
C4K32_RS19530	COG0492	ferredoxin-NADP+ reductase activity
C4K32_RS19535	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4K32_RS19540	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4K32_RS19545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4K32_RS19550	COG0542	response to heat
C4K32_RS19555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4K32_RS19560	COG1278	Cold shock
C4K32_RS19585	COG0482	sulfurtransferase activity
C4K32_RS19590	COG2915	High frequency lysogenization protein hflD homolog
C4K32_RS19600	COG2850	peptidyl-arginine hydroxylation
C4K32_RS19605	COG2153	protein acetylation
C4K32_RS19620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K32_RS19625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K32_RS19630	COG0649	NAD binding
C4K32_RS19630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K32_RS19645	COG1034	ATP synthesis coupled electron transport
C4K32_RS19650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4K32_RS19655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K32_RS19665	COG0713	ATP synthesis coupled electron transport
C4K32_RS19680	COG1007	ATP synthesis coupled electron transport
C4K32_RS19690	COG2944	sequence-specific DNA binding
C4K32_RS19705	COG0395	ABC-type sugar transport system, permease component
C4K32_RS19715	COG3842	ATPase activity
C4K32_RS19720	COG3842	ATPase activity
C4K32_RS19725	COG3284	Transcriptional regulator
C4K32_RS19730	COG0215	cysteine-tRNA ligase activity
C4K32_RS19735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K32_RS19745	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K32_RS19750	COG2814	Major facilitator Superfamily
C4K32_RS19755	COG1566	PFAM secretion protein HlyD family protein
C4K32_RS19765	COG1846	Transcriptional regulator
C4K32_RS19770	COG2911	Protein conserved in bacteria
C4K32_RS19775	COG0729	surface antigen
C4K32_RS19785	COG0708	Exodeoxyribonuclease III
C4K32_RS19795	COG2885	chlorophyll binding
C4K32_RS19800	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS19810	COG0789	Transcriptional regulator
C4K32_RS19825	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS19830	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS19835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K32_RS19850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K32_RS19860	COG2866	Carboxypeptidase
C4K32_RS19870	COG2814	Major facilitator Superfamily
C4K32_RS19875	COG3038	cytochrome b561
C4K32_RS19930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K32_RS19940	COG0217	transcriptional regulatory protein
C4K32_RS19945	COG0583	DNA-binding transcription factor activity
C4K32_RS19950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4K32_RS19955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K32_RS19960	COG3038	cytochrome b561
C4K32_RS19970	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K32_RS19970	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS20000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K32_RS20010	COG0776	regulation of translation
C4K32_RS20015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K32_RS20020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4K32_RS20025	COG0740	serine-type endopeptidase activity
C4K32_RS20030	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4K32_RS20050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4K32_RS20055	COG1686	Belongs to the peptidase S11 family
C4K32_RS20065	COG1253	flavin adenine dinucleotide binding
C4K32_RS20075	COG0583	DNA-binding transcription factor activity
C4K32_RS20085	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4K32_RS20095	COG3132	Protein of unknown function, DUF480
C4K32_RS20105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K32_RS20125	COG0628	permease
C4K32_RS20130	COG0826	peptidase U32
C4K32_RS20135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS20140	COG4215	(ABC) transporter
C4K32_RS20160	COG1737	Transcriptional regulator
C4K32_RS20170	COG2056	Na+-H+ antiporter family
C4K32_RS20175	COG0840	transmembrane signaling receptor activity
C4K32_RS20205	COG0720	synthase
C4K32_RS20210	COG0596	Alpha beta hydrolase
C4K32_RS20220	COG1051	belongs to the nudix hydrolase family
C4K32_RS20225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K32_RS20230	COG0402	S-adenosylhomocysteine deaminase activity
C4K32_RS20235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K32_RS20250	COG1725	Transcriptional regulator
C4K32_RS20255	COG2207	Transcriptional regulator
C4K32_RS20270	COG0583	DNA-binding transcription factor activity
C4K32_RS20275	COG0583	DNA-binding transcription factor activity
C4K32_RS20285	COG1522	sequence-specific DNA binding
C4K32_RS20300	COG2223	nitrite transmembrane transporter activity
C4K32_RS20305	COG4772	TonB-dependent receptor
C4K32_RS20315	COG1595	DNA-templated transcription, initiation
C4K32_RS20330	COG3210	domain, Protein
C4K32_RS20340	COG2197	response regulator
C4K32_RS20370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS20375	COG2274	protein secretion by the type I secretion system
C4K32_RS20380	COG1538	Outer membrane efflux protein
C4K32_RS20385	COG2080	2 iron, 2 sulfur cluster binding
C4K32_RS20390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K32_RS20390	COG2010	Cytochrome c
C4K32_RS20395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K32_RS20395	COG2010	Cytochrome c
C4K32_RS20415	COG0840	transmembrane signaling receptor activity
C4K32_RS20420	COG4774	siderophore transport
C4K32_RS20430	COG0300	oxidoreductase activity
C4K32_RS20435	COG1864	DNA RNA non-specific endonuclease
C4K32_RS20435	COG3591	Belongs to the peptidase S1B family
C4K32_RS20455	COG4106	trans-aconitate 2-methyltransferase activity
C4K32_RS20470	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS20475	COG1942	4-Oxalocrotonate Tautomerase
C4K32_RS20485	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4K32_RS20515	COG2814	Major facilitator Superfamily
C4K32_RS20545	COG3485	protocatechuate 3,4-dioxygenase
C4K32_RS20550	COG4829	muconolactone delta-isomerase
C4K32_RS20555	COG4948	Mandelate Racemase Muconate Lactonizing
C4K32_RS20670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4K32_RS20685	COG2814	Major facilitator Superfamily
C4K32_RS20720	COG0154	amidase activity
C4K32_RS20745	COG0583	DNA-binding transcription factor activity
C4K32_RS20755	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS20765	COG1335	isochorismatase
C4K32_RS20790	COG3318	Belongs to the UPF0149 family
C4K32_RS20790	COG3012	SEC-C Motif Domain Protein
C4K32_RS20805	COG0730	response to heat
C4K32_RS20835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K32_RS20845	COG1335	isochorismatase
C4K32_RS20850	COG1335	isochorismatase
C4K32_RS20860	COG0583	DNA-binding transcription factor activity
C4K32_RS20870	COG0656	L-ascorbic acid biosynthetic process
C4K32_RS20890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4K32_RS20905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS20910	COG1136	(ABC) transporter
C4K32_RS20910	COG0577	efflux transmembrane transporter activity
C4K32_RS20975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4K32_RS20985	COG1309	transcriptional regulator
C4K32_RS20995	COG0596	Alpha beta hydrolase
C4K32_RS21000	COG4977	sequence-specific DNA binding
C4K32_RS21065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K32_RS21075	COG0840	transmembrane signaling receptor activity
C4K32_RS21105	COG1132	(ABC) transporter
C4K32_RS21145	COG0583	DNA-binding transcription factor activity
C4K32_RS21195	COG0477	Major facilitator Superfamily
C4K32_RS21200	COG0583	DNA-binding transcription factor activity
C4K32_RS21205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K32_RS21210	COG0235	Class ii aldolase
C4K32_RS21215	COG0477	Major facilitator Superfamily
C4K32_RS21220	COG0583	DNA-binding transcription factor activity
C4K32_RS21225	COG0768	penicillin binding
C4K32_RS21260	COG5006	permease, DMT superfamily
C4K32_RS21270	COG1309	transcriptional regulator
C4K32_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS21300	COG0431	NADPH-dependent FMN reductase
C4K32_RS21305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS21315	COG3829	transcription factor binding
C4K32_RS21335	COG2011	ABC-type metal ion transport system permease component
C4K32_RS21375	COG1121	(ABC) transporter
C4K32_RS21380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K32_RS21390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K32_RS21405	COG0642	Histidine kinase
C4K32_RS21415	COG4232	protein-disulfide reductase activity
C4K32_RS21420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4K32_RS21445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K32_RS21480	COG1309	transcriptional regulator
C4K32_RS21495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K32_RS21500	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS21505	COG1024	Enoyl-CoA hydratase
C4K32_RS21520	COG3123	guanosine phosphorylase activity
C4K32_RS21525	COG0633	Ferredoxin
C4K32_RS21525	COG3217	Mosc domain protein beta barrel domain protein
C4K32_RS21540	COG3851	Histidine kinase
C4K32_RS21545	COG2197	response regulator
C4K32_RS21550	COG1597	lipid kinase activity
C4K32_RS21565	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K32_RS21570	COG0746	molybdenum cofactor guanylyltransferase activity
C4K32_RS21580	COG0564	pseudouridine synthase activity
C4K32_RS21605	COG0004	ammonium transporteR
C4K32_RS21625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K32_RS21645	COG2197	response regulator
C4K32_RS21650	COG2205	protein histidine kinase activity
C4K32_RS21650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS21655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4K32_RS21660	COG1956	GAF domain-containing protein
C4K32_RS21670	COG0784	Response regulator, receiver
C4K32_RS21670	COG2205	protein histidine kinase activity
C4K32_RS21670	COG5002	protein histidine kinase activity
C4K32_RS21675	COG1846	Transcriptional regulator
C4K32_RS21680	COG0386	Belongs to the glutathione peroxidase family
C4K32_RS21685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K32_RS21690	COG0436	Aminotransferase
C4K32_RS21695	COG0501	Belongs to the peptidase M48B family
C4K32_RS21700	COG0500	methyltransferase
C4K32_RS21705	COG3384	dioxygenase
C4K32_RS21720	COG1024	Enoyl-CoA hydratase
C4K32_RS21730	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4K32_RS21735	COG3214	Protein conserved in bacteria
C4K32_RS21745	COG0583	DNA-binding transcription factor activity
C4K32_RS21755	COG0583	DNA-binding transcription factor activity
C4K32_RS21760	COG1846	Transcriptional regulator
C4K32_RS21765	COG1764	response to oxidative stress
C4K32_RS21775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4K32_RS21790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K32_RS21810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K32_RS21840	COG1376	ErfK ybiS ycfS ynhG family protein
C4K32_RS21855	COG4181	ATPase activity
C4K32_RS21860	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4K32_RS21865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K32_RS21880	COG2197	response regulator
C4K32_RS21890	COG2259	Doxx family
C4K32_RS21895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K32_RS21935	COG0745	RESPONSE REGULATOR receiver
C4K32_RS21940	COG2205	protein histidine kinase activity
C4K32_RS21945	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4K32_RS21955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4K32_RS21990	COG4221	oxidoreductase activity
C4K32_RS21995	COG1555	photosystem II stabilization
C4K32_RS21995	COG1596	polysaccharide export
C4K32_RS22000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K32_RS22010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K32_RS22015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K32_RS22035	COG0367	asparagine synthase
C4K32_RS22050	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS22060	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4K32_RS22070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4K32_RS22075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4K32_RS22095	COG0776	regulation of translation
C4K32_RS22110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4K32_RS22115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4K32_RS22120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K32_RS22130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4K32_RS22140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4K32_RS22145	COG0402	S-adenosylhomocysteine deaminase activity
C4K32_RS22150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K32_RS22155	COG0546	phosphoglycolate phosphatase activity
C4K32_RS22160	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS22175	COG5002	protein histidine kinase activity
C4K32_RS22175	COG5001	Diguanylate cyclase
C4K32_RS22190	COG1054	Belongs to the UPF0176 family
C4K32_RS22195	COG0271	Belongs to the BolA IbaG family
C4K32_RS22205	COG0114	fumarate hydratase activity
C4K32_RS22210	COG0697	spore germination
C4K32_RS22215	COG0183	Belongs to the thiolase family
C4K32_RS22220	COG2326	polyphosphate kinase activity
C4K32_RS22225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS22225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4K32_RS22230	COG0367	asparagine synthase
C4K32_RS22235	COG0189	ligase activity
C4K32_RS22235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K32_RS22240	COG1363	Peptidase, m42
C4K32_RS22245	COG3089	Belongs to the UPF0270 family
C4K32_RS22250	COG1742	UPF0060 membrane protein
C4K32_RS22265	COG1368	sulfuric ester hydrolase activity
C4K32_RS22285	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS22300	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C4K32_RS22305	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4K32_RS22310	COG0235	Class ii aldolase
C4K32_RS22320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4K32_RS22325	COG1073	alpha beta
C4K32_RS22350	COG2840	Smr protein MutS2
C4K32_RS22355	COG0302	gtp cyclohydrolase
C4K32_RS22365	COG0625	glutathione transferase activity
C4K32_RS22370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K32_RS22380	COG2252	PERMEase
C4K32_RS22410	COG4266	Belongs to the allantoicase family
C4K32_RS22415	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4K32_RS22425	COG2233	PERMEase
C4K32_RS22455	COG1560	Kdo2-lipid A biosynthetic process
C4K32_RS22460	COG0850	regulation of cytokinetic process
C4K32_RS22465	COG2894	cell division
C4K32_RS22470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4K32_RS22475	COG0564	pseudouridine synthase activity
C4K32_RS22485	COG1362	aminopeptidase activity
C4K32_RS22495	COG0668	transmembrane transport
C4K32_RS22500	COG1473	amidohydrolase
C4K32_RS22530	COG3842	ATPase activity
C4K32_RS22540	COG4221	oxidoreductase activity
C4K32_RS22540	COG3321	synthase
C4K32_RS22540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K32_RS22540	COG0604	alcohol dehydrogenase
C4K32_RS22550	COG2200	EAL domain
C4K32_RS22575	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K32_RS22580	COG2010	Cytochrome c
C4K32_RS22610	COG2974	May be involved in recombination
C4K32_RS22615	COG0385	Bile acid
C4K32_RS22620	COG2076	Multidrug Resistance protein
C4K32_RS22625	COG0477	Major facilitator Superfamily
C4K32_RS22650	COG2202	Pas domain
C4K32_RS22650	COG2205	protein histidine kinase activity
C4K32_RS22700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4K32_RS22705	COG0406	alpha-ribazole phosphatase activity
C4K32_RS22710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4K32_RS22720	COG1492	cobalamin metabolic process
C4K32_RS22735	COG0778	Nitroreductase
C4K32_RS22740	COG1797	cobyrinic acid a,c-diamide synthase activity
C4K32_RS22765	COG0791	NLP P60 protein
C4K32_RS22770	COG0791	NLP P60 protein
C4K32_RS22775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K32_RS22780	COG0628	permease
C4K32_RS22790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4K32_RS22795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4K32_RS22810	COG3122	Protein conserved in bacteria
C4K32_RS22815	COG3956	TIGRFAM MazG family protein
C4K32_RS22820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K32_RS22825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K32_RS22845	COG2205	protein histidine kinase activity
C4K32_RS22845	COG5002	protein histidine kinase activity
C4K32_RS22845	COG0784	Response regulator, receiver
C4K32_RS22850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K32_RS22870	COG1393	Belongs to the ArsC family
C4K32_RS22890	COG0037	tRNA processing
C4K32_RS22900	COG3091	SprT-like family
C4K32_RS22905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K32_RS22945	COG2205	protein histidine kinase activity
C4K32_RS22950	COG0745	RESPONSE REGULATOR receiver
C4K32_RS22955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K32_RS22955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K32_RS22960	COG1749	Flagellar hook protein flgE
C4K32_RS22970	COG1558	bacterial-type flagellum-dependent cell motility
C4K32_RS22975	COG1815	bacterial-type flagellum-dependent cell motility
C4K32_RS22980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K32_RS22985	COG0835	chemotaxis
C4K32_RS22985	COG0784	Response regulator, receiver
C4K32_RS23005	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4K32_RS23010	COG0477	Major facilitator Superfamily
C4K32_RS23020	COG2205	protein histidine kinase activity
C4K32_RS23050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K32_RS23070	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4K32_RS23080	COG2239	Acts as a magnesium transporter
C4K32_RS23100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K32_RS23105	COG0527	aspartate kinase activity
C4K32_RS23110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K32_RS23115	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4K32_RS23120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K32_RS23125	COG2988	succinylglutamate desuccinylase activity
C4K32_RS23135	COG3724	N-succinylarginine dihydrolase activity
C4K32_RS23140	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS23155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K32_RS23185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS23190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K32_RS23200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K32_RS23235	COG0563	adenylate kinase activity
C4K32_RS23250	COG3706	GGDEF domain
C4K32_RS23270	COG0504	CTP synthase activity
C4K32_RS23275	COG2329	Antibiotic biosynthesis monooxygenase
C4K32_RS23285	COG0584	glycerophosphoryl diester phosphodiesterase
C4K32_RS23315	COG0306	phosphate transporter
C4K32_RS23325	COG1984	allophanate hydrolase subunit 2
C4K32_RS23335	COG0439	Biotin carboxylase
C4K32_RS23345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K32_RS23360	COG3008	intermembrane lipid transfer
C4K32_RS23365	COG2995	paraquat-inducible protein a
C4K32_RS23370	COG2995	paraquat-inducible protein a
C4K32_RS23385	COG0583	DNA-binding transcription factor activity
C4K32_RS23390	COG4941	Belongs to the sigma-70 factor family
C4K32_RS23400	COG3795	YCII-related domain
C4K32_RS23445	COG0436	Aminotransferase
C4K32_RS23455	COG3265	gluconokinase activity
C4K32_RS23460	COG1609	Transcriptional regulator
C4K32_RS23475	COG0583	DNA-binding transcription factor activity
C4K32_RS23490	COG2271	Major facilitator Superfamily
C4K32_RS23500	COG0583	DNA-binding transcription factor activity
C4K32_RS23510	COG2986	histidine ammonia-lyase
C4K32_RS23520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS23535	COG3712	iron ion homeostasis
C4K32_RS23540	COG1595	DNA-templated transcription, initiation
C4K32_RS23565	COG0242	peptide deformylase activity
C4K32_RS23570	COG1295	ribonuclease BN
C4K32_RS23585	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS23590	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS23595	COG2267	carboxylic ester hydrolase activity
C4K32_RS23600	COG2030	dehydratase
C4K32_RS23625	COG3530	Putative quorum-sensing-regulated virulence factor
C4K32_RS23630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K32_RS23635	COG0800	Aldolase
C4K32_RS23650	COG1737	Transcriptional regulator
C4K32_RS23660	COG0676	glucose-6-phosphate 1-epimerase activity
C4K32_RS23670	COG3842	ATPase activity
C4K32_RS23675	COG0395	ABC-type sugar transport system, permease component
C4K32_RS23680	COG1175	transmembrane transport
C4K32_RS23685	COG1653	transport
C4K32_RS23720	COG1803	Methylglyoxal synthase
C4K32_RS23730	COG3712	iron ion homeostasis
C4K32_RS23735	COG4771	TonB-dependent receptor
C4K32_RS23745	COG2832	Protein of unknown function (DUF454)
C4K32_RS23750	COG0840	transmembrane signaling receptor activity
C4K32_RS23755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K32_RS23780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K32_RS23800	COG0509	glycine decarboxylation via glycine cleavage system
C4K32_RS23805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K32_RS23805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K32_RS23810	COG1760	l-serine dehydratase
C4K32_RS23815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K32_RS23820	COG1278	Cold shock
C4K32_RS23830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4K32_RS23835	COG4964	Belongs to the GSP D family
C4K32_RS23920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K32_RS23925	COG0602	queuosine metabolic process
C4K32_RS23930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4K32_RS23935	COG2885	chlorophyll binding
C4K32_RS23940	COG0823	Involved in the tonB-independent uptake of proteins
C4K32_RS23960	COG0824	Thioesterase
C4K32_RS23965	COG2255	four-way junction helicase activity
C4K32_RS23970	COG0632	four-way junction helicase activity
C4K32_RS23975	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4K32_RS23980	COG0217	transcriptional regulatory protein
C4K32_RS23985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4K32_RS23995	COG0783	Belongs to the Dps family
C4K32_RS24005	COG2900	Belongs to the SlyX family
C4K32_RS24025	COG0668	transmembrane transport
C4K32_RS24030	COG1666	GTP binding
C4K32_RS24040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS24040	COG4191	Histidine kinase
C4K32_RS24045	COG2096	Adenosyltransferase
C4K32_RS24060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4K32_RS24065	COG0653	protein targeting
C4K32_RS24075	COG0433	COG0433 Predicted ATPase
C4K32_RS24085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K32_RS24085	COG0438	transferase activity, transferring glycosyl groups
C4K32_RS24110	COG2925	Exonuclease
C4K32_RS24135	COG0714	Associated with various cellular activities
C4K32_RS24155	COG0469	pyruvate kinase activity
C4K32_RS24170	COG3706	GGDEF domain
C4K32_RS24185	COG4191	Histidine kinase
C4K32_RS24195	COG0477	Major facilitator Superfamily
C4K32_RS24225	COG2207	Transcriptional regulator
C4K32_RS24230	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS24240	COG0583	DNA-binding transcription factor activity
C4K32_RS24245	COG2910	NAD(P)H-binding
C4K32_RS24255	COG0583	DNA-binding transcription factor activity
C4K32_RS24285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K32_RS24290	COG0583	DNA-binding transcription factor activity
C4K32_RS24305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4K32_RS24335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS24340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS24350	COG3642	lipopolysaccharide core region biosynthetic process
C4K32_RS24360	COG0642	Histidine kinase
C4K32_RS24375	COG0459	protein refolding
C4K32_RS24380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4K32_RS24390	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4K32_RS24400	COG1028	Short-chain dehydrogenase reductase Sdr
C4K32_RS24405	COG0489	protein tyrosine kinase activity
C4K32_RS24410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K32_RS24410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K32_RS24415	COG4657	Part of a membrane complex involved in electron transport
C4K32_RS24420	COG2878	Part of a membrane complex involved in electron transport
C4K32_RS24425	COG4658	electron transport chain
C4K32_RS24430	COG4659	FMN binding
C4K32_RS24435	COG4660	Part of a membrane complex involved in electron transport
C4K32_RS24440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4K32_RS24450	COG2197	response regulator
C4K32_RS24455	COG0137	argininosuccinate synthase activity
C4K32_RS24465	COG0418	dihydroorotase activity
C4K32_RS24470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K32_RS24475	COG0450	alkyl hydroperoxide reductase
C4K32_RS24490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4K32_RS24495	COG3383	formate dehydrogenase (NAD+) activity
C4K32_RS24505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K32_RS24510	COG3842	ATPase activity
C4K32_RS24515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4K32_RS24525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4K32_RS24540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS24545	COG0765	amino acid transport
C4K32_RS24550	COG0765	amino acid transport
C4K32_RS24555	COG1126	abc transporter atp-binding protein
C4K32_RS24585	COG2076	Multidrug Resistance protein
C4K32_RS24605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K32_RS24620	COG4191	Histidine kinase
C4K32_RS24640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K32_RS24645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4K32_RS24650	COG0583	DNA-binding transcription factor activity
C4K32_RS24660	COG1280	lysine exporter protein (LysE YggA)
C4K32_RS24670	COG0254	rRNA binding
C4K32_RS24675	COG2197	response regulator
C4K32_RS24680	COG0069	glutamate synthase activity
C4K32_RS24705	COG2246	polysaccharide biosynthetic process
C4K32_RS24720	COG1113	amino acid transport
C4K32_RS24730	COG1695	Transcriptional regulator
C4K32_RS24735	COG2375	cellular response to nickel ion
C4K32_RS24745	COG4628	conserved protein (DUF2132)
C4K32_RS24750	COG4206	TonB-dependent receptor
C4K32_RS24785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K32_RS24800	COG2226	methyltransferase
C4K32_RS24805	COG0500	methyltransferase
C4K32_RS24810	COG0590	tRNA wobble adenosine to inosine editing
C4K32_RS24825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K32_RS24825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K32_RS24835	COG0366	Alpha amylase catalytic
C4K32_RS24840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K32_RS24840	COG1263	PTS System
C4K32_RS24845	COG2188	Transcriptional regulator
C4K32_RS24860	COG0519	Catalyzes the synthesis of GMP from XMP
C4K32_RS24860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K32_RS24885	COG1570	exodeoxyribonuclease VII activity
C4K32_RS24890	COG0739	heme binding
C4K32_RS24895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K32_RS24905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K32_RS24910	COG0436	Aminotransferase
C4K32_RS24915	COG1160	GTP binding
C4K32_RS24930	COG0124	histidyl-tRNA synthetase
C4K32_RS24935	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4K32_RS24940	COG1426	Protein conserved in bacteria
C4K32_RS24950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4K32_RS24955	COG0105	UTP biosynthetic process
C4K32_RS24965	COG0633	Ferredoxin
C4K32_RS24970	COG0443	Heat shock 70 kDa protein
C4K32_RS24975	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K32_RS24990	COG1104	cysteine desulfurase activity
C4K32_RS25000	COG1045	serine acetyltransferase
C4K32_RS25015	COG3134	Outer membrane lipoprotein
C4K32_RS25030	COG1862	Preprotein translocase
C4K32_RS25035	COG0343	queuine tRNA-ribosyltransferase activity
C4K32_RS25040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4K32_RS25065	COG2853	Lipoprotein
C4K32_RS25095	COG0586	Pfam SNARE associated Golgi protein
C4K32_RS25150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K32_RS25175	COG2771	luxR family
C4K32_RS25180	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS25185	COG0154	amidase activity
C4K32_RS25200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K32_RS25215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K32_RS25220	COG0109	protoheme IX farnesyltransferase activity
C4K32_RS25230	COG1845	cytochrome c oxidase, subunit III
C4K32_RS25235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K32_RS25240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K32_RS25250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K32_RS25260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K32_RS25260	COG1017	nitric oxide dioxygenase activity
C4K32_RS25265	COG3604	Transcriptional regulator
C4K32_RS25270	COG0784	Response regulator, receiver
C4K32_RS25270	COG0835	chemotaxis
C4K32_RS25300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K32_RS25310	COG5002	protein histidine kinase activity
C4K32_RS25325	COG2203	Gaf domain
C4K32_RS25325	COG3706	GGDEF domain
C4K32_RS25325	COG4251	negative regulation of phosphorylation
C4K32_RS25325	COG5001	Diguanylate cyclase
C4K32_RS25330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4K32_RS25335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4K32_RS25350	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K32_RS25355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K32_RS25360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K32_RS25365	COG0772	Belongs to the SEDS family
C4K32_RS25370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4K32_RS25375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K32_RS25380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4K32_RS25385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K32_RS25400	COG0275	rRNA processing
C4K32_RS25405	COG2001	Belongs to the MraZ family
C4K32_RS25420	COG3107	peptidoglycan biosynthetic process
C4K32_RS25425	COG0792	nuclease activity
C4K32_RS25430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4K32_RS25435	COG2823	Periplasmic or secreted lipoprotein
C4K32_RS25440	COG2969	positive regulation of protein catabolic process
C4K32_RS25445	COG0625	glutathione transferase activity
C4K32_RS25450	COG2857	Cytochrome c1
C4K32_RS25455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4K32_RS25460	COG0723	plastoquinol--plastocyanin reductase activity
C4K32_RS25465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4K32_RS25470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4K32_RS25475	COG0667	Aldo Keto reductase
C4K32_RS25480	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS25490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K32_RS25495	COG0180	Tryptophanyl-tRNA synthetase
C4K32_RS25515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K32_RS25520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K32_RS25540	COG0642	Histidine kinase
C4K32_RS25545	COG2909	trisaccharide binding
C4K32_RS25560	COG0318	PFAM AMP-dependent synthetase and ligase
C4K32_RS25580	COG1280	lysine exporter protein (LysE YggA)
C4K32_RS25585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K32_RS25590	COG2813	Specifically methylates the guanine in position
C4K32_RS25595	COG2119	membrane
C4K32_RS25600	COG0501	Belongs to the peptidase M48B family
C4K32_RS25605	COG0840	transmembrane signaling receptor activity
C4K32_RS25610	COG2135	peptidase activity
C4K32_RS25670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4K32_RS25675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4K32_RS25685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4K32_RS25690	COG1090	epimerase
C4K32_RS25695	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4K32_RS25715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4K32_RS25720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4K32_RS25730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4K32_RS25735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4K32_RS25745	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4K32_RS25750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4K32_RS25760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4K32_RS25765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4K32_RS25770	COG0193	aminoacyl-tRNA hydrolase activity
C4K32_RS25780	COG2197	response regulator
C4K32_RS25785	COG2205	protein histidine kinase activity
C4K32_RS25785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS25790	COG3397	chitin binding
C4K32_RS25855	COG2258	MOSC domain
C4K32_RS25880	COG2223	nitrite transmembrane transporter activity
C4K32_RS25935	COG0367	asparagine synthase
C4K32_RS25940	COG0405	Gamma-glutamyltransferase
C4K32_RS25955	COG4680	protein conserved in bacteria
C4K32_RS25965	COG0789	Transcriptional regulator
C4K32_RS25980	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K32_RS26010	COG0662	Cupin 2, conserved barrel domain protein
C4K32_RS26020	COG0583	DNA-binding transcription factor activity
C4K32_RS26025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K32_RS26035	COG0583	DNA-binding transcription factor activity
C4K32_RS26100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K32_RS26115	COG2031	fatty acid transporter
C4K32_RS26130	COG0288	reversible hydration of carbon dioxide
C4K32_RS26140	COG0456	acetyltransferase
C4K32_RS26165	COG3008	intermembrane lipid transfer
C4K32_RS26170	COG2995	paraquat-inducible protein a
C4K32_RS26175	COG2995	paraquat-inducible protein a
C4K32_RS26210	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4K32_RS26215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4K32_RS26220	COG1183	phosphatidylcholine synthase activity
C4K32_RS26225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4K32_RS26235	COG0028	Belongs to the TPP enzyme family
C4K32_RS26255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K32_RS26285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4K32_RS26290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K32_RS26295	COG4558	Periplasmic binding protein
C4K32_RS26305	COG1489	DNA binding
C4K32_RS26310	COG0436	Aminotransferase
C4K32_RS26320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K32_RS26330	COG4191	Histidine kinase
C4K32_RS26355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K32_RS26360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4K32_RS26370	COG0166	Belongs to the GPI family
C4K32_RS26375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K32_RS26390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K32_RS26400	COG2823	Periplasmic or secreted lipoprotein
C4K32_RS26415	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4K32_RS26420	COG0237	dephospho-CoA kinase activity
C4K32_RS26425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4K32_RS26445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K32_RS26500	COG0728	peptidoglycan biosynthetic process
C4K32_RS26515	COG1252	NADH dehydrogenase
C4K32_RS26525	COG3121	Chaperone
C4K32_RS26530	COG3188	usher protein
C4K32_RS26555	COG0542	response to heat
C4K32_RS26585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS26625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4K32_RS26630	COG1047	Peptidyl-prolyl cis-trans
C4K32_RS26635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4K32_RS26640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4K32_RS26645	COG0196	riboflavin kinase activity
C4K32_RS26660	COG0268	Binds directly to 16S ribosomal RNA
C4K32_RS26665	COG3045	CreA protein
C4K32_RS26670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4K32_RS26675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4K32_RS26680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4K32_RS26685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4K32_RS26690	COG0142	geranyltranstransferase activity
C4K32_RS26695	COG2824	Alkylphosphonate utilization operon protein PhnA
C4K32_RS26700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K32_RS26705	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K32_RS26715	COG2862	Uncharacterized protein family, UPF0114
C4K32_RS26730	COG1067	ATP-dependent peptidase activity
C4K32_RS26750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K32_RS26760	COG0488	(ABC) transporter
C4K32_RS26770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K32_RS26785	COG2186	Transcriptional regulator
C4K32_RS26795	COG0523	cobalamin synthesis protein
C4K32_RS26800	COG2879	small protein
C4K32_RS26805	COG1966	Carbon starvation protein
C4K32_RS26840	COG1970	mechanosensitive ion channel activity
C4K32_RS26850	COG2813	Specifically methylates the guanine in position
C4K32_RS26860	COG1294	oxidase, subunit
C4K32_RS26865	COG1271	oxidase subunit
C4K32_RS26890	COG2252	PERMEase
C4K32_RS26895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K32_RS26920	COG1629	transport
C4K32_RS26935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K32_RS26940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K32_RS26945	COG3135	benzoate transporter
C4K32_RS26955	COG1309	transcriptional regulator
C4K32_RS26960	COG1082	Xylose isomerase domain protein TIM barrel
C4K32_RS26960	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4K32_RS26980	COG0673	inositol 2-dehydrogenase activity
C4K32_RS26990	COG1053	succinate dehydrogenase
C4K32_RS26995	COG3485	protocatechuate 3,4-dioxygenase
C4K32_RS27000	COG3485	protocatechuate 3,4-dioxygenase
C4K32_RS27005	COG0583	DNA-binding transcription factor activity
C4K32_RS27010	COG2321	neutral zinc metallopeptidase
C4K32_RS27025	COG1946	Acyl-CoA thioesterase
C4K32_RS27035	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4K32_RS27045	COG0513	Belongs to the DEAD box helicase family
C4K32_RS27055	COG0697	spore germination
C4K32_RS27060	COG1522	sequence-specific DNA binding
C4K32_RS27065	COG1199	ATP-dependent helicase activity
C4K32_RS27065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K32_RS27075	COG3416	Protein conserved in bacteria
C4K32_RS27090	COG1643	Atp-dependent helicase
C4K32_RS27110	COG1522	sequence-specific DNA binding
C4K32_RS27125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K32_RS27130	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS27135	COG2205	protein histidine kinase activity
C4K32_RS27135	COG2198	Histidine kinase
C4K32_RS27135	COG0784	Response regulator, receiver
C4K32_RS27140	COG0351	phosphomethylpyrimidine kinase
C4K32_RS27145	COG0352	thiamine-phosphate diphosphorylase activity
C4K32_RS27150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K32_RS27165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K32_RS27170	COG1702	phosphate starvation-inducible protein PhoH
C4K32_RS27175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4K32_RS27180	COG4535	Mg2 and Co2 transporter CorC
C4K32_RS27185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4K32_RS27200	COG0495	leucyl-tRNA aminoacylation
C4K32_RS27220	COG2951	lytic endotransglycosylase activity
C4K32_RS27225	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4K32_RS27230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4K32_RS27235	COG0321	lipoyl(octanoyl) transferase activity
C4K32_RS27240	COG2921	Belongs to the UPF0250 family
C4K32_RS27245	COG1686	Belongs to the peptidase S11 family
C4K32_RS27255	COG2951	lytic endotransglycosylase activity
C4K32_RS27260	COG0772	Belongs to the SEDS family
C4K32_RS27265	COG0768	penicillin binding
C4K32_RS27270	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4K32_RS27280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4K32_RS27285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4K32_RS27290	COG2094	Belongs to the DNA glycosylase MPG family
C4K32_RS27295	COG0586	Pfam SNARE associated Golgi protein
C4K32_RS27305	COG1346	cytolysis
C4K32_RS27325	COG0702	epimerase
C4K32_RS27340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K32_RS27345	COG3284	Transcriptional regulator
C4K32_RS27355	COG0531	amino acid
C4K32_RS27360	COG4303	Ethanolamine ammonia lyase large subunit
C4K32_RS27365	COG4302	ethanolamine ammonia-lyase activity
C4K32_RS27370	COG0456	acetyltransferase
C4K32_RS27375	COG0586	Pfam SNARE associated Golgi protein
C4K32_RS27380	COG3228	Belongs to the MtfA family
C4K32_RS27385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4K32_RS27390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K32_RS27400	COG0583	DNA-binding transcription factor activity
C4K32_RS27420	COG1335	isochorismatase
C4K32_RS27440	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K32_RS27450	COG0604	alcohol dehydrogenase
C4K32_RS27450	COG3321	synthase
C4K32_RS27455	COG0640	Transcriptional regulator
C4K32_RS27465	COG1722	exodeoxyribonuclease VII activity
C4K32_RS27470	COG0142	geranyltranstransferase activity
C4K32_RS27475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4K32_RS27480	COG4206	TonB-dependent receptor
C4K32_RS27495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4K32_RS27505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4K32_RS27515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4K32_RS27520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K32_RS27535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K32_RS27535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K32_RS27540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K32_RS27550	COG2264	protein methyltransferase activity
C4K32_RS27555	COG3118	belongs to the thioredoxin family
C4K32_RS27585	COG3047	cAMP biosynthetic process
C4K32_RS27600	COG1201	RNA secondary structure unwinding
C4K32_RS27605	COG2814	Major facilitator Superfamily
C4K32_RS27615	COG3568	Endonuclease Exonuclease Phosphatase
C4K32_RS27620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K32_RS27625	COG0392	lysyltransferase activity
C4K32_RS27635	COG1335	isochorismatase
C4K32_RS27640	COG0629	single-stranded DNA binding
C4K32_RS27645	COG2814	Major facilitator Superfamily
C4K32_RS27650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4K32_RS27655	COG2193	ferroxidase activity
C4K32_RS27665	COG0203	ribosomal protein L17
C4K32_RS27670	COG0202	RNA polymerase activity
C4K32_RS27675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4K32_RS27680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4K32_RS27685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4K32_RS27690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4K32_RS27700	COG0200	Binds to the 23S rRNA
C4K32_RS27705	COG1841	ribosomal large subunit assembly
C4K32_RS27710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4K32_RS27715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4K32_RS27720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4K32_RS27725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4K32_RS27730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4K32_RS27735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4K32_RS27740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4K32_RS27745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4K32_RS27750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4K32_RS27755	COG0255	Belongs to the universal ribosomal protein uL29 family
C4K32_RS27760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4K32_RS27765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4K32_RS27770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4K32_RS27775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4K32_RS27780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4K32_RS27785	COG0089	rRNA binding
C4K32_RS27790	COG0088	Forms part of the polypeptide exit tunnel
C4K32_RS27795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4K32_RS27800	COG0051	transcription antitermination factor activity, RNA binding
C4K32_RS27805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K32_RS27810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K32_RS27815	COG0049	tRNA binding
C4K32_RS27820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4K32_RS27825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4K32_RS27830	COG0085	RNA polymerase activity
C4K32_RS27835	COG0222	ribosome binding
C4K32_RS27840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4K32_RS27845	COG0081	regulation of translation
C4K32_RS27850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4K32_RS27870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K32_RS27895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4K32_RS27935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4K32_RS27940	COG0739	heme binding
C4K32_RS27945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4K32_RS27950	COG0316	Belongs to the HesB IscA family
C4K32_RS27955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K32_RS27960	COG1981	membrane
C4K32_RS27975	COG4221	oxidoreductase activity
C4K32_RS27980	COG0537	adenosine 5'-monophosphoramidase activity
C4K32_RS27985	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4K32_RS27990	COG1765	OsmC-like protein
C4K32_RS28005	COG0134	indole-3-glycerol-phosphate synthase activity
C4K32_RS28010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K32_RS28015	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K32_RS28025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K32_RS28030	COG0546	phosphoglycolate phosphatase activity
C4K32_RS28035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4K32_RS28040	COG1454	alcohol dehydrogenase
C4K32_RS28050	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K32_RS28060	COG3842	ATPase activity
C4K32_RS28065	COG2197	response regulator
C4K32_RS28070	COG4585	Histidine kinase
C4K32_RS28080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K32_RS28085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K32_RS28090	COG3178	'Phosphotransferase
C4K32_RS28095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4K32_RS28100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K32_RS28105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4K32_RS28110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4K32_RS28115	COG2967	ApaG domain
C4K32_RS28120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K32_RS28125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K32_RS28130	COG2766	serine protein kinase
C4K32_RS28135	COG2718	Belongs to the UPF0229 family
C4K32_RS28140	COG2719	SpoVR family
C4K32_RS28145	COG0617	tRNA 3'-terminal CCA addition
C4K32_RS28155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K32_RS28160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4K32_RS28165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4K32_RS28170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4K32_RS28175	COG0358	DNA primase activity
C4K32_RS28180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4K32_RS28195	COG4974	Belongs to the 'phage' integrase family
C4K32_RS28245	COG4695	Portal protein
C4K32_RS28410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K32_RS28415	COG1025	Belongs to the peptidase M16 family
C4K32_RS28425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K32_RS28430	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4K32_RS28440	COG0535	radical SAM domain protein
C4K32_RS28465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K32_RS28470	COG2258	MOSC domain
C4K32_RS28475	COG0583	DNA-binding transcription factor activity
C4K32_RS28480	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS28485	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS28490	COG3706	GGDEF domain
C4K32_RS28495	COG1960	acyl-CoA dehydrogenase activity
C4K32_RS28515	COG2226	methyltransferase
C4K32_RS28515	COG1073	alpha beta
C4K32_RS28520	COG0156	8-amino-7-oxononanoate synthase activity
C4K32_RS28525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4K32_RS28535	COG2005	Transcriptional regulator
C4K32_RS28535	COG3585	molybdate ion transport
C4K32_RS28545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4K32_RS28560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4K32_RS28580	COG1595	DNA-templated transcription, initiation
C4K32_RS28585	COG3712	iron ion homeostasis
C4K32_RS28590	COG4774	siderophore transport
C4K32_RS28610	COG0625	glutathione transferase activity
C4K32_RS28615	COG4452	Inner membrane protein CreD
C4K32_RS28620	COG2205	protein histidine kinase activity
C4K32_RS28625	COG0745	RESPONSE REGULATOR receiver
C4K32_RS28630	COG0189	ligase activity
C4K32_RS28630	COG4067	protein conserved in archaea
C4K32_RS28635	COG0204	Acyl-transferase
C4K32_RS28645	COG1063	alcohol dehydrogenase
C4K32_RS28675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K32_RS28695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K32_RS28695	COG1017	nitric oxide dioxygenase activity
C4K32_RS28705	COG4638	Rieske (2fe-2S)
C4K32_RS28715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4K32_RS28720	COG2181	nitrate reductase activity
C4K32_RS28720	COG0247	lactate metabolic process
C4K32_RS28725	COG1902	pentaerythritol trinitrate reductase activity
C4K32_RS28725	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K32_RS28775	COG3246	L-lysine catabolic process to acetate
C4K32_RS28780	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K32_RS28810	COG1760	l-serine dehydratase
C4K32_RS28820	COG4176	ABC-type proline glycine betaine transport system permease component
C4K32_RS28825	COG4175	Glycine betaine
C4K32_RS28830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K32_RS28835	COG1309	transcriptional regulator
C4K32_RS28840	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS28845	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K32_RS28860	COG0312	modulator of DNA gyrase
C4K32_RS28865	COG0477	Major facilitator Superfamily
C4K32_RS28870	COG0513	Belongs to the DEAD box helicase family
C4K32_RS28875	COG2081	HI0933 family
C4K32_RS28880	COG1289	transmembrane transporter activity
C4K32_RS28890	COG2153	protein acetylation
C4K32_RS28900	COG1451	nucleotide metabolic process
C4K32_RS28930	COG0126	phosphoglycerate kinase activity
C4K32_RS28935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4K32_RS28945	COG0640	Transcriptional regulator
C4K32_RS28950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4K32_RS28955	COG1422	Protein of unknown function (DUF1090)
C4K32_RS28980	COG2814	Major facilitator Superfamily
C4K32_RS28995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4K32_RS29000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4K32_RS29015	COG0513	Belongs to the DEAD box helicase family
C4K32_RS29020	COG2353	YceI-like domain
C4K32_RS29025	COG3038	cytochrome b561
C4K32_RS29035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4K32_RS29060	COG1272	protein, Hemolysin III
C4K32_RS29080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K32_RS29100	COG3052	prosthetic group binding
C4K32_RS29105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4K32_RS29125	COG2198	Histidine kinase
C4K32_RS29125	COG0643	Histidine kinase
C4K32_RS29125	COG0784	Response regulator, receiver
C4K32_RS29150	COG0189	ligase activity
C4K32_RS29160	COG1678	Uncharacterized ACR, COG1678
C4K32_RS29165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4K32_RS29170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4K32_RS29175	COG0540	Belongs to the ATCase OTCase family
C4K32_RS29180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K32_RS29190	COG0791	NLP P60 protein
C4K32_RS29215	COG1872	DUF167
C4K32_RS29220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K32_RS29225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K32_RS29225	COG2813	Specifically methylates the guanine in position
C4K32_RS29235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4K32_RS29240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4K32_RS29255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4K32_RS29260	COG2022	thiamine diphosphate biosynthetic process
C4K32_RS29270	COG2363	Small membrane protein
C4K32_RS29275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K32_RS29285	COG2177	Part of the ABC transporter FtsEX involved in
C4K32_RS29290	COG2884	Cell division ATP-binding protein ftsE
C4K32_RS29295	COG0552	protein localization to endoplasmic reticulum
C4K32_RS29300	COG0612	Peptidase, M16
C4K32_RS29305	COG0612	Peptidase, M16
C4K32_RS29310	COG0742	ribosomal rna small subunit methyltransferase
C4K32_RS29345	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K32_RS29350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4K32_RS29355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4K32_RS29360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4K32_RS29370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K32_RS29380	COG0129	dihydroxy-acid dehydratase activity
C4K32_RS29390	COG1823	symporter activity
C4K32_RS29405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K32_RS29420	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K32_RS29425	COG1178	ABC-type Fe3 transport system permease component
C4K32_RS29430	COG3842	ATPase activity
C4K32_RS29435	COG0583	DNA-binding transcription factor activity
C4K32_RS29445	COG0789	Transcriptional regulator
C4K32_RS29450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4K32_RS29455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4K32_RS29460	COG0730	response to heat
C4K32_RS29475	COG0494	nUDIX hydrolase
C4K32_RS29490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K32_RS29495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4K32_RS29500	COG2234	aminopeptidase activity
C4K32_RS29505	COG3204	pilus organization
C4K32_RS29510	COG3204	pilus organization
C4K32_RS29515	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K32_RS29520	COG0277	FAD linked oxidase domain protein
C4K32_RS29525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K32_RS29535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS29540	COG1683	Conserved Protein
C4K32_RS29570	COG1177	transmembrane transport
C4K32_RS29575	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K32_RS29580	COG3842	ATPase activity
C4K32_RS29600	COG0174	glutamine synthetase
C4K32_RS29605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K32_RS29610	COG0174	glutamine synthetase
C4K32_RS29625	COG1116	anion transmembrane transporter activity
C4K32_RS29630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K32_RS29635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K32_RS29640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K32_RS29645	COG0431	NADPH-dependent FMN reductase
C4K32_RS29650	COG0450	alkyl hydroperoxide reductase
C4K32_RS29660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4K32_RS29660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K32_RS29665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K32_RS29675	COG1522	sequence-specific DNA binding
C4K32_RS29685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4K32_RS29700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K32_RS29700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K32_RS29705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K32_RS29720	COG0509	glycine decarboxylation via glycine cleavage system
C4K32_RS29725	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K32_RS29730	COG1178	ABC-type Fe3 transport system permease component
C4K32_RS29740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K32_RS29745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K32_RS29750	COG0006	proline dipeptidase activity
C4K32_RS29755	COG3079	Belongs to the UPF0149 family
C4K32_RS29775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4K32_RS29785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K32_RS29790	COG1129	ABC transporter
C4K32_RS29790	COG0842	Transport permease protein
C4K32_RS29795	COG0842	Transport permease protein
C4K32_RS29805	COG0604	alcohol dehydrogenase
C4K32_RS29810	COG2271	Major facilitator Superfamily
C4K32_RS29825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4K32_RS29840	COG2186	Transcriptional regulator
C4K32_RS29845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS29850	COG0765	amino acid transport
C4K32_RS29855	COG0765	amino acid transport
C4K32_RS29860	COG1126	abc transporter atp-binding protein
C4K32_RS29865	COG0248	Ppx GppA phosphatase
C4K32_RS29870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4K32_RS29880	COG0586	Pfam SNARE associated Golgi protein
C4K32_RS29890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4K32_RS29895	COG1671	Belongs to the UPF0178 family
C4K32_RS29900	COG0672	)-iron permease
C4K32_RS29905	COG1280	lysine exporter protein (LysE YggA)
C4K32_RS29915	COG0488	(ABC) transporter
C4K32_RS29940	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K32_RS29960	COG0181	hydroxymethylbilane synthase activity
C4K32_RS29970	COG0165	Argininosuccinate lyase
C4K32_RS29975	COG0625	glutathione transferase activity
C4K32_RS29990	COG3072	Adenylate cyclase
C4K32_RS29995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K32_RS30005	COG1965	Belongs to the frataxin family
C4K32_RS30015	COG0019	diaminopimelate decarboxylase activity
C4K32_RS30020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K32_RS30030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K32_RS30035	COG1011	Hydrolase
C4K32_RS30045	COG0432	Pfam Uncharacterised protein family UPF0047
C4K32_RS30050	COG0004	ammonium transporteR
C4K32_RS30055	COG0347	Belongs to the P(II) protein family
C4K32_RS30070	COG0529	Catalyzes the synthesis of activated sulfate
C4K32_RS30080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K32_RS30085	COG0574	Belongs to the PEP-utilizing enzyme family
C4K32_RS30085	COG3848	Pyruvate phosphate dikinase
C4K32_RS30090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K32_RS30095	COG1213	nucleotidyl transferase
C4K32_RS30100	COG0606	chelatase, subunit chli
C4K32_RS30130	COG0583	DNA-binding transcription factor activity
C4K32_RS30135	COG0534	Mate efflux family protein
C4K32_RS30150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K32_RS30155	COG0427	acetyl-CoA hydrolase
C4K32_RS30170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4K32_RS30175	COG0251	oxidation-reduction process
C4K32_RS30180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS30195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K32_RS30205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K32_RS30210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K32_RS30220	COG1012	belongs to the aldehyde dehydrogenase family
C4K32_RS30230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4K32_RS30235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4K32_RS30240	COG0747	negative chemotaxis
C4K32_RS30245	COG2003	Belongs to the UPF0758 family
C4K32_RS30250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4K32_RS30255	COG0756	dUTP diphosphatase activity
C4K32_RS30260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K32_RS30265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K32_RS30270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4K32_RS30275	COG0708	Exodeoxyribonuclease III
C4K32_RS30285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4K32_RS30290	COG1561	YicC-like family, N-terminal region
C4K32_RS30295	COG0194	GDP metabolic process
C4K32_RS30300	COG1758	RNA polymerase activity
C4K32_RS30305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K32_RS30330	COG0848	biopolymer transport protein
C4K32_RS30340	COG0583	DNA-binding transcription factor activity
C4K32_RS30345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4K32_RS30420	COG0515	serine threonine protein kinase
C4K32_RS30460	COG2204	response regulator
C4K32_RS30540	COG3161	chorismate lyase activity
C4K32_RS30545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4K32_RS30565	COG1253	flavin adenine dinucleotide binding
C4K32_RS30570	COG0739	heme binding
C4K32_RS30590	COG0704	Plays a role in the regulation of phosphate uptake
C4K32_RS30595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4K32_RS30600	COG0573	inorganic phosphate transmembrane transporter activity
C4K32_RS30615	COG0477	Major facilitator Superfamily
C4K32_RS30620	COG1607	acyl-coa hydrolase
C4K32_RS30650	COG0583	DNA-binding transcription factor activity
C4K32_RS30655	COG1027	Aspartate ammonia-lyase
C4K32_RS30670	COG1115	amino acid carrier protein
C4K32_RS30675	COG0252	asparaginase activity
C4K32_RS30700	COG2391	methyltransferase activity
C4K32_RS30730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K32_RS30735	COG0765	amino acid transport
C4K32_RS30745	COG5016	pyruvate
C4K32_RS30745	COG0511	ligase activity, forming carbon-carbon bonds
C4K32_RS30750	COG0439	Biotin carboxylase
C4K32_RS30755	COG0583	DNA-binding transcription factor activity
C4K32_RS30775	COG0210	DNA helicase
C4K32_RS30795	COG4651	solute:proton antiporter activity
C4K32_RS30795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K32_RS30800	COG1607	acyl-coa hydrolase
C4K32_RS30805	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4K32_RS30815	COG0523	cobalamin synthesis protein
C4K32_RS30840	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K32_RS30845	COG1469	GTP cyclohydrolase I activity
C4K32_RS30850	COG1121	(ABC) transporter
C4K32_RS30860	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4K32_RS30865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K32_RS30875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K32_RS30880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K32_RS30890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K32_RS30895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4K32_RS30900	COG2217	Heavy metal translocating P-type atpase
C4K32_RS30920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4K32_RS30925	COG2267	carboxylic ester hydrolase activity
C4K32_RS30930	COG0671	phosphoesterase, PA-phosphatase related
C4K32_RS30930	COG2453	phosphatase
C4K32_RS30945	COG4589	Belongs to the CDS family
C4K32_RS30950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K32_RS30960	COG1280	lysine exporter protein (LysE YggA)
C4K32_RS30965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K32_RS30970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K32_RS30970	COG2755	lipolytic protein G-D-S-L family
C4K32_RS31005	COG0297	glycogen (starch) synthase activity
C4K32_RS31020	COG0625	glutathione transferase activity
C4K32_RS31025	COG0583	DNA-binding transcription factor activity
C4K32_RS31030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K32_RS31045	COG0494	nUDIX hydrolase
C4K32_RS31050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K32_RS31065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K32_RS31070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K32_RS31150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K32_RS31155	COG1349	DNA-binding transcription factor activity
C4K32_RS31160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K32_RS31165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4K32_RS31170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4K32_RS31175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4K32_RS31180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4K32_RS31185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4K32_RS31190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4K32_RS31200	COG0356	it plays a direct role in the translocation of protons across the membrane
C4K32_RS31205	COG3312	ion transport
C4K32_RS31210	COG1475	DNA binding
C4K32_RS31215	COG1192	Involved in chromosome partitioning
C4K32_RS31220	COG0357	Ribosomal RNA small subunit methyltransferase G
C4K32_RS31225	COG0445	tRNA wobble uridine modification
C4K32_RS31230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K32_RS31235	COG0706	membrane insertase activity
C4K32_RS31240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4K32_RS31245	COG0594	ribonuclease P activity
C4K32_RS31250	COG0230	Belongs to the bacterial ribosomal protein bL34 family