locus-tag	class	description
C4K30_RS00010	COG0592	DNA-directed DNA polymerase activity
C4K30_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K30_RS00020	COG0187	DNA topoisomerase II activity
C4K30_RS00045	COG5002	protein histidine kinase activity
C4K30_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4K30_RS00060	COG0751	glycine-tRNA ligase activity
C4K30_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
C4K30_RS00070	COG2818	Glycosylase
C4K30_RS00090	COG0569	domain protein
C4K30_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4K30_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K30_RS00105	COG0242	peptide deformylase activity
C4K30_RS00115	COG0758	DNA mediated transformation
C4K30_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
C4K30_RS00130	COG0408	coproporphyrinogen oxidase activity
C4K30_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K30_RS00150	COG3119	arylsulfatase activity
C4K30_RS00175	COG0159	tryptophan synthase activity
C4K30_RS00180	COG0133	tryptophan synthase activity
C4K30_RS00195	COG3360	Dodecin
C4K30_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS00210	COG1764	response to oxidative stress
C4K30_RS00240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4K30_RS00245	COG0339	signal peptide processing
C4K30_RS00250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4K30_RS00285	COG0659	secondary active sulfate transmembrane transporter activity
C4K30_RS00295	COG1565	acr, cog1565
C4K30_RS00295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K30_RS00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K30_RS00305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4K30_RS00335	COG0109	protoheme IX farnesyltransferase activity
C4K30_RS00350	COG2011	ABC-type metal ion transport system permease component
C4K30_RS00355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K30_RS00365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K30_RS00370	COG1121	(ABC) transporter
C4K30_RS00375	COG0735	belongs to the Fur family
C4K30_RS00380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4K30_RS00400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4K30_RS00405	COG3245	cytochrome
C4K30_RS00415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K30_RS00430	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K30_RS00435	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K30_RS00440	COG5002	protein histidine kinase activity
C4K30_RS00445	COG2204	response regulator
C4K30_RS00455	COG5487	UPF0391 membrane protein
C4K30_RS00465	COG1301	dicarboxylic acid transport
C4K30_RS00470	COG0700	Nucleoside recognition
C4K30_RS00475	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K30_RS00485	COG1127	ABC transporter
C4K30_RS00490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K30_RS00500	COG0612	Peptidase, M16
C4K30_RS00505	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K30_RS00510	COG0861	Integral membrane protein TerC family
C4K30_RS00515	COG2851	Citrate transporter
C4K30_RS00555	COG0427	acetyl-CoA hydrolase
C4K30_RS00575	COG0583	DNA-binding transcription factor activity
C4K30_RS00580	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS00635	COG3712	iron ion homeostasis
C4K30_RS00640	COG1595	DNA-templated transcription, initiation
C4K30_RS00645	COG0840	transmembrane signaling receptor activity
C4K30_RS00675	COG1802	Transcriptional regulator
C4K30_RS00685	COG3300	MHYT domain
C4K30_RS00685	COG5001	Diguanylate cyclase
C4K30_RS00700	COG1538	Outer membrane efflux protein
C4K30_RS00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS00715	COG2175	clavaminate synthase activity
C4K30_RS00725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K30_RS00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS00820	COG0529	Catalyzes the synthesis of activated sulfate
C4K30_RS00835	COG0330	HflC and HflK could
C4K30_RS00870	COG1289	transmembrane transporter activity
C4K30_RS00880	COG1566	PFAM secretion protein HlyD family protein
C4K30_RS00895	COG5339	Protein conserved in bacteria
C4K30_RS00900	COG0457	Tetratricopeptide repeat
C4K30_RS00905	COG1649	PFAM Uncharacterised BCR, COG1649
C4K30_RS00905	COG0726	polysaccharide deacetylase
C4K30_RS00910	COG1215	transferase activity, transferring glycosyl groups
C4K30_RS00920	COG1881	PFAM PEBP family protein
C4K30_RS00925	COG2304	oxidoreductase activity
C4K30_RS00930	COG1595	DNA-templated transcription, initiation
C4K30_RS01005	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K30_RS01015	COG0745	RESPONSE REGULATOR receiver
C4K30_RS01020	COG2199	diguanylate cyclase activity
C4K30_RS01040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4K30_RS01050	COG4208	sulfate ABC transporter
C4K30_RS01055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4K30_RS01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS01095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS01120	COG4771	TonB-dependent receptor
C4K30_RS01180	COG2807	transmembrane transport
C4K30_RS01185	COG0590	tRNA wobble adenosine to inosine editing
C4K30_RS01195	COG0583	DNA-binding transcription factor activity
C4K30_RS01230	COG0765	amino acid transport
C4K30_RS01235	COG0765	amino acid transport
C4K30_RS01240	COG1126	abc transporter atp-binding protein
C4K30_RS01245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS01250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K30_RS01255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS01265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS01280	COG2011	ABC-type metal ion transport system permease component
C4K30_RS01285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4K30_RS01315	COG1126	abc transporter atp-binding protein
C4K30_RS01320	COG0765	amino acid transport
C4K30_RS01325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS01330	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4K30_RS01335	COG1045	serine acetyltransferase
C4K30_RS01340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K30_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS01360	COG0583	DNA-binding transcription factor activity
C4K30_RS01375	COG0667	Aldo Keto reductase
C4K30_RS01380	COG1487	ribonuclease activity
C4K30_RS01390	COG2175	clavaminate synthase activity
C4K30_RS01395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS01400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4K30_RS01405	COG4521	taurine ABC transporter
C4K30_RS01410	COG2918	glutathione biosynthetic process
C4K30_RS01420	COG2183	response to ionizing radiation
C4K30_RS01430	COG2205	protein histidine kinase activity
C4K30_RS01435	COG0189	ligase activity
C4K30_RS01440	COG0189	ligase activity
C4K30_RS01440	COG4067	protein conserved in archaea
C4K30_RS01445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4K30_RS01455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4K30_RS01460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4K30_RS01500	COG0514	ATP-dependent DNA helicase (RecQ)
C4K30_RS01505	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS01505	COG1024	Enoyl-CoA hydratase
C4K30_RS01510	COG0824	Thioesterase
C4K30_RS01520	COG0243	molybdopterin cofactor binding
C4K30_RS01525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4K30_RS01535	COG1652	LysM domain
C4K30_RS01540	COG1011	Hydrolase
C4K30_RS01545	COG0494	nUDIX hydrolase
C4K30_RS01570	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4K30_RS01580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4K30_RS01590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K30_RS01600	COG2957	Belongs to the agmatine deiminase family
C4K30_RS01655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K30_RS01660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K30_RS01665	COG1845	cytochrome c oxidase, subunit III
C4K30_RS01670	COG1845	cytochrome c oxidase, subunit III
C4K30_RS01685	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4K30_RS01740	COG0736	holo-[acyl-carrier-protein] synthase activity
C4K30_RS01775	COG0582	viral genome integration into host DNA
C4K30_RS01800	COG4215	(ABC) transporter
C4K30_RS01875	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4K30_RS01880	COG1194	a g-specific adenine glycosylase
C4K30_RS01895	COG2223	nitrite transmembrane transporter activity
C4K30_RS01900	COG0131	Imidazoleglycerol-phosphate dehydratase
C4K30_RS01905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4K30_RS01915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4K30_RS01920	COG0107	imidazoleglycerol-phosphate synthase activity
C4K30_RS01930	COG2861	carbohydrate metabolic process
C4K30_RS01935	COG0793	Belongs to the peptidase S41A family
C4K30_RS01940	COG4942	peptidase
C4K30_RS01945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4K30_RS01960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4K30_RS01980	COG3852	Histidine kinase
C4K30_RS01985	COG0477	Major facilitator Superfamily
C4K30_RS01990	COG0583	DNA-binding transcription factor activity
C4K30_RS01995	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K30_RS02005	COG1024	Enoyl-CoA hydratase
C4K30_RS02010	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS02015	COG0183	Belongs to the thiolase family
C4K30_RS02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K30_RS02050	COG0301	tRNA thio-modification
C4K30_RS02055	COG1217	gtp-binding protein TYPA
C4K30_RS02065	COG0058	SHG alpha-glucan phosphorylase activity
C4K30_RS02070	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4K30_RS02095	COG0402	S-adenosylhomocysteine deaminase activity
C4K30_RS02100	COG2188	Transcriptional regulator
C4K30_RS02110	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4K30_RS02115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K30_RS02125	COG4176	ABC-type proline glycine betaine transport system permease component
C4K30_RS02130	COG4175	Glycine betaine
C4K30_RS02130	COG0517	IMP dehydrogenase activity
C4K30_RS02135	COG2986	histidine ammonia-lyase
C4K30_RS02140	COG2986	histidine ammonia-lyase
C4K30_RS02150	COG1228	amidohydrolase
C4K30_RS02160	COG0596	Alpha beta hydrolase
C4K30_RS02165	COG1490	D-aminoacyl-tRNA deacylase activity
C4K30_RS02170	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K30_RS02175	COG2943	transferase activity, transferring hexosyl groups
C4K30_RS02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS02185	COG0765	amino acid transport
C4K30_RS02190	COG1126	abc transporter atp-binding protein
C4K30_RS02195	COG0840	transmembrane signaling receptor activity
C4K30_RS02210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K30_RS02215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4K30_RS02220	COG0140	phosphoribosyl-ATP diphosphatase activity
C4K30_RS02225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K30_RS02230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K30_RS02240	COG2226	methyltransferase
C4K30_RS02285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4K30_RS02290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4K30_RS02300	COG0018	arginyl-trna synthetase
C4K30_RS02305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4K30_RS02310	COG0254	rRNA binding
C4K30_RS02320	COG0281	malic enzyme
C4K30_RS02355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4K30_RS02360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4K30_RS02375	COG0069	glutamate synthase activity
C4K30_RS02375	COG0067	glutamate synthase
C4K30_RS02375	COG0070	glutamate synthase
C4K30_RS02380	COG0493	'glutamate synthase
C4K30_RS02385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4K30_RS02390	COG3111	PFAM Bacterial OB fold (BOF) protein
C4K30_RS02395	COG2814	Major facilitator Superfamily
C4K30_RS02400	COG0583	DNA-binding transcription factor activity
C4K30_RS02420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K30_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS02435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K30_RS02445	COG2226	methyltransferase
C4K30_RS02450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K30_RS02475	COG2986	histidine ammonia-lyase
C4K30_RS02500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS02505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS02520	COG1192	Involved in chromosome partitioning
C4K30_RS02525	COG3118	belongs to the thioredoxin family
C4K30_RS02530	COG4680	protein conserved in bacteria
C4K30_RS02540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4K30_RS02545	COG3264	Mechanosensitive ion channel
C4K30_RS02545	COG1196	nuclear chromosome segregation
C4K30_RS02550	COG3263	regulation of cellular component size
C4K30_RS02570	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS02575	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K30_RS02575	COG0506	proline dehydrogenase activity
C4K30_RS02575	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4K30_RS02580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K30_RS02585	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4K30_RS02590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K30_RS02610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4K30_RS02615	COG0859	PFAM glycosyl transferase family 9
C4K30_RS02620	COG0859	PFAM glycosyl transferase family 9
C4K30_RS02625	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS02650	COG2192	nodulation
C4K30_RS02655	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS02680	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS02695	COG1132	(ABC) transporter
C4K30_RS02715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4K30_RS02715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4K30_RS02725	COG0667	Aldo Keto reductase
C4K30_RS02745	COG1519	Transferase
C4K30_RS02750	COG1538	Outer membrane efflux protein
C4K30_RS02755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4K30_RS02770	COG0494	nUDIX hydrolase
C4K30_RS02780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4K30_RS02785	COG3150	esterase
C4K30_RS02820	COG3830	Belongs to the UPF0237 family
C4K30_RS02820	COG0560	Phosphoserine phosphatase
C4K30_RS02825	COG0688	phosphatidylethanolamine metabolic process
C4K30_RS02850	COG1162	GTPase activity
C4K30_RS02855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4K30_RS02860	COG2860	membrane
C4K30_RS02870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4K30_RS02870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4K30_RS02875	COG0802	atpase or kinase
C4K30_RS02880	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K30_RS02885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4K30_RS02890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4K30_RS02895	COG1923	regulation of RNA biosynthetic process
C4K30_RS02900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4K30_RS02905	COG0330	HflC and HflK could
C4K30_RS02910	COG0330	HflC and HflK could
C4K30_RS02915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4K30_RS02920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4K30_RS02925	COG0840	transmembrane signaling receptor activity
C4K30_RS02930	COG1178	ABC-type Fe3 transport system permease component
C4K30_RS02935	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K30_RS02950	COG0557	exoribonuclease II activity
C4K30_RS02955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4K30_RS02960	COG0360	Binds together with S18 to 16S ribosomal RNA
C4K30_RS02965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4K30_RS02975	COG0359	binds to the 23S rRNA
C4K30_RS02980	COG0305	Participates in initiation and elongation during chromosome replication
C4K30_RS02985	COG1032	radical SAM domain protein
C4K30_RS03000	COG2307	Protein conserved in bacteria
C4K30_RS03000	COG2308	Evidence 4 Homologs of previously reported genes of
C4K30_RS03010	COG0494	nUDIX hydrolase
C4K30_RS03030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4K30_RS03035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4K30_RS03040	COG0583	DNA-binding transcription factor activity
C4K30_RS03045	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS03050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS03060	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4K30_RS03085	COG4221	oxidoreductase activity
C4K30_RS03105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4K30_RS03110	COG0830	nickel cation binding
C4K30_RS03115	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4K30_RS03130	COG2982	Protein involved in outer membrane biogenesis
C4K30_RS03135	COG0583	DNA-binding transcription factor activity
C4K30_RS03140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K30_RS03150	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4K30_RS03155	COG0697	spore germination
C4K30_RS03160	COG2207	Transcriptional regulator
C4K30_RS03175	COG0443	Heat shock 70 kDa protein
C4K30_RS03180	COG0484	heat shock protein binding
C4K30_RS03185	COG0789	Transcriptional regulator
C4K30_RS03195	COG0804	urea catabolic process
C4K30_RS03200	COG0832	Belongs to the urease beta subunit family
C4K30_RS03215	COG0831	urea catabolic process
C4K30_RS03220	COG0829	nickel cation binding
C4K30_RS03230	COG0411	ABC transporter
C4K30_RS03245	COG0683	leucine binding
C4K30_RS03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K30_RS03260	COG1120	ATPase activity
C4K30_RS03300	COG3657	addiction module killer protein
C4K30_RS03310	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4K30_RS03320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K30_RS03345	COG2095	MarC family integral membrane protein
C4K30_RS03355	COG0151	Belongs to the GarS family
C4K30_RS03360	COG0138	bifunctional purine biosynthesis protein purh
C4K30_RS03370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K30_RS03380	COG2264	protein methyltransferase activity
C4K30_RS03395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K30_RS03425	COG0023	Translation Initiation Factor
C4K30_RS03430	COG1166	arginine decarboxylase activity
C4K30_RS03435	COG0534	Mate efflux family protein
C4K30_RS03440	COG2373	Large extracellular alpha-helical protein
C4K30_RS03450	COG4953	penicillin-binding protein 1C
C4K30_RS03460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K30_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS03585	COG2217	Heavy metal translocating P-type atpase
C4K30_RS03615	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4K30_RS03620	COG0583	DNA-binding transcription factor activity
C4K30_RS03625	COG0477	Major facilitator Superfamily
C4K30_RS03630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4K30_RS03645	COG0387	Pfam Sodium calcium exchanger
C4K30_RS03670	COG1079	Belongs to the binding-protein-dependent transport system permease family
C4K30_RS03675	COG4603	Belongs to the binding-protein-dependent transport system permease family
C4K30_RS03680	COG3845	ABC transporter
C4K30_RS03690	COG1309	transcriptional regulator
C4K30_RS03695	COG2233	PERMEase
C4K30_RS03745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4K30_RS03750	COG1074	ATP-dependent DNA helicase activity
C4K30_RS03755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K30_RS03765	COG2199	diguanylate cyclase activity
C4K30_RS03820	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4K30_RS03825	COG3483	tryptophan 2,3-dioxygenase activity
C4K30_RS03830	COG1113	amino acid transport
C4K30_RS03835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K30_RS03835	COG0543	2 iron, 2 sulfur cluster binding
C4K30_RS03840	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4K30_RS03845	COG4638	Rieske (2fe-2S)
C4K30_RS03855	COG1522	sequence-specific DNA binding
C4K30_RS03865	COG1113	amino acid transport
C4K30_RS03870	COG0583	DNA-binding transcription factor activity
C4K30_RS03885	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K30_RS03890	COG0583	DNA-binding transcription factor activity
C4K30_RS03905	COG2610	gluconate transmembrane transporter activity
C4K30_RS03915	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4K30_RS03950	COG0840	transmembrane signaling receptor activity
C4K30_RS03990	COG1309	transcriptional regulator
C4K30_RS04050	COG2814	Major facilitator Superfamily
C4K30_RS04090	COG4983	Phage plasmid primase, P4 family domain protein
C4K30_RS04100	COG0582	viral genome integration into host DNA
C4K30_RS04130	COG0247	lactate metabolic process
C4K30_RS04135	COG1620	l-lactate permease
C4K30_RS04140	COG2186	Transcriptional regulator
C4K30_RS04145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4K30_RS04150	COG0733	neurotransmitter:sodium symporter activity
C4K30_RS04160	COG2914	Belongs to the UPF0125 (RnfH) family
C4K30_RS04165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4K30_RS04175	COG0497	DNA recombination
C4K30_RS04180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4K30_RS04185	COG0443	Heat shock 70 kDa protein
C4K30_RS04190	COG0484	heat shock protein binding
C4K30_RS04195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4K30_RS04200	COG0505	Belongs to the CarA family
C4K30_RS04205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4K30_RS04210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K30_RS04225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4K30_RS04235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4K30_RS04240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K30_RS04245	COG0149	triose-phosphate isomerase activity
C4K30_RS04250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4K30_RS04270	COG0195	Participates in both transcription termination and antitermination
C4K30_RS04275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4K30_RS04280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4K30_RS04285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4K30_RS04290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4K30_RS04295	COG1185	polyribonucleotide nucleotidyltransferase activity
C4K30_RS04305	COG0583	DNA-binding transcription factor activity
C4K30_RS04310	COG2957	Belongs to the agmatine deiminase family
C4K30_RS04330	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS04360	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K30_RS04375	COG0084	hydrolase, TatD family'
C4K30_RS04380	COG1609	Transcriptional regulator
C4K30_RS04385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K30_RS04385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K30_RS04390	COG1105	Belongs to the carbohydrate kinase PfkB family
C4K30_RS04395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4K30_RS04395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K30_RS04395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4K30_RS04410	COG2814	Major facilitator Superfamily
C4K30_RS04420	COG1309	transcriptional regulator
C4K30_RS04430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4K30_RS04435	COG4774	siderophore transport
C4K30_RS04440	COG3128	pkhd-type hydroxylase
C4K30_RS04450	COG0019	diaminopimelate decarboxylase activity
C4K30_RS04475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4K30_RS04485	COG4608	Belongs to the ABC transporter superfamily
C4K30_RS04490	COG0444	Belongs to the ABC transporter superfamily
C4K30_RS04495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K30_RS04500	COG0601	transmembrane transport
C4K30_RS04505	COG0747	negative chemotaxis
C4K30_RS04515	COG0747	negative chemotaxis
C4K30_RS04520	COG0747	negative chemotaxis
C4K30_RS04530	COG1917	Cupin 2, conserved barrel domain protein
C4K30_RS04530	COG1396	sequence-specific DNA binding
C4K30_RS04545	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4K30_RS04550	COG4178	(ABC) transporter
C4K30_RS04570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K30_RS04580	COG2271	Major facilitator Superfamily
C4K30_RS04585	COG2721	sulfolactate sulfo-lyase activity
C4K30_RS04595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K30_RS04605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K30_RS04610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K30_RS04615	COG0154	amidase activity
C4K30_RS04620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4K30_RS04625	COG1077	Cell shape determining protein MreB Mrl
C4K30_RS04630	COG1792	Involved in formation and maintenance of cell shape
C4K30_RS04640	COG0424	maF-like protein
C4K30_RS04645	COG1530	ribonuclease E activity
C4K30_RS04655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K30_RS04660	COG0312	modulator of DNA gyrase
C4K30_RS04665	COG3028	Belongs to the UPF0307 family
C4K30_RS04670	COG0312	modulator of DNA gyrase
C4K30_RS04705	COG1660	Displays ATPase and GTPase activities
C4K30_RS04720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4K30_RS04725	COG1137	ATPase activity
C4K30_RS04730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4K30_RS04740	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4K30_RS04750	COG1127	ABC transporter
C4K30_RS04755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4K30_RS04760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4K30_RS04780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4K30_RS04785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4K30_RS04790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4K30_RS04795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K30_RS04800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K30_RS04815	COG0175	sulfate reduction
C4K30_RS04825	COG0204	Acyl-transferase
C4K30_RS04830	COG0857	belongs to the CobB CobQ family
C4K30_RS04830	COG0280	phosphate acetyltransferase
C4K30_RS04845	COG0386	Belongs to the glutathione peroxidase family
C4K30_RS04860	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4K30_RS04870	COG0492	ferredoxin-NADP+ reductase activity
C4K30_RS04885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K30_RS04890	COG0302	gtp cyclohydrolase
C4K30_RS04905	COG0789	Transcriptional regulator
C4K30_RS04915	COG1366	Belongs to the anti-sigma-factor antagonist family
C4K30_RS04925	COG0583	DNA-binding transcription factor activity
C4K30_RS04930	COG1380	Effector of murein hydrolase LrgA
C4K30_RS04935	COG1346	cytolysis
C4K30_RS04945	COG0596	Alpha beta hydrolase
C4K30_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS04970	COG2909	trisaccharide binding
C4K30_RS04980	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4K30_RS04985	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K30_RS05005	COG2226	methyltransferase
C4K30_RS05050	COG0814	amino acid
C4K30_RS05055	COG1760	l-serine dehydratase
C4K30_RS05060	COG0583	DNA-binding transcription factor activity
C4K30_RS05070	COG4772	TonB-dependent receptor
C4K30_RS05075	COG3712	iron ion homeostasis
C4K30_RS05080	COG1595	DNA-templated transcription, initiation
C4K30_RS05100	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K30_RS05110	COG0697	spore germination
C4K30_RS05115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K30_RS05120	COG0583	DNA-binding transcription factor activity
C4K30_RS05140	COG1566	PFAM secretion protein HlyD family protein
C4K30_RS05160	COG0300	oxidoreductase activity
C4K30_RS05210	COG0662	Cupin 2, conserved barrel domain protein
C4K30_RS05210	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4K30_RS05225	COG1696	Membrane protein involved in D-alanine export
C4K30_RS05240	COG3420	alginic acid biosynthetic process
C4K30_RS05250	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4K30_RS05255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS05260	COG1215	transferase activity, transferring glycosyl groups
C4K30_RS05270	COG3022	response to hydroperoxide
C4K30_RS05280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4K30_RS05285	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K30_RS05290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K30_RS05300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS05320	COG0513	Belongs to the DEAD box helicase family
C4K30_RS05330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS05335	COG4597	amino acid ABC transporter
C4K30_RS05340	COG0765	amino acid transport
C4K30_RS05345	COG1126	abc transporter atp-binding protein
C4K30_RS05350	COG2944	sequence-specific DNA binding
C4K30_RS05360	COG2186	Transcriptional regulator
C4K30_RS05365	COG2807	transmembrane transport
C4K30_RS05375	COG2827	Endonuclease containing a URI domain
C4K30_RS05390	COG3081	Nucleoid-associated protein
C4K30_RS05400	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4K30_RS05405	COG0525	valine-tRNA ligase activity
C4K30_RS05420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4K30_RS05425	COG0795	lipopolysaccharide-transporting ATPase activity
C4K30_RS05430	COG0795	lipopolysaccharide-transporting ATPase activity
C4K30_RS05435	COG0481	GTPase activity
C4K30_RS05440	COG0681	Belongs to the peptidase S26 family
C4K30_RS05450	COG0571	ribonuclease III activity
C4K30_RS05455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4K30_RS05460	COG1381	Involved in DNA repair and RecF pathway recombination
C4K30_RS05465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4K30_RS05470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K30_RS05475	COG0047	phosphoribosylformylglycinamidine synthase activity
C4K30_RS05475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4K30_RS05485	COG2190	(PTS) system
C4K30_RS05485	COG1263	PTS System
C4K30_RS05485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K30_RS05490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K30_RS05490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K30_RS05495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K30_RS05500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4K30_RS05505	COG2188	Transcriptional regulator
C4K30_RS05520	COG0494	nUDIX hydrolase
C4K30_RS05540	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4K30_RS05545	COG0477	Major facilitator Superfamily
C4K30_RS05550	COG4536	flavin adenine dinucleotide binding
C4K30_RS05560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4K30_RS05565	COG0228	four-way junction DNA binding
C4K30_RS05570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4K30_RS05575	COG0336	Belongs to the RNA methyltransferase TrmD family
C4K30_RS05580	COG0335	large ribosomal subunit rRNA binding
C4K30_RS05585	COG1607	acyl-coa hydrolase
C4K30_RS05595	COG4974	Belongs to the 'phage' integrase family
C4K30_RS05615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS05615	COG2205	protein histidine kinase activity
C4K30_RS05625	COG2197	response regulator
C4K30_RS05645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K30_RS05660	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS05665	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4K30_RS05675	COG2311	Membrane
C4K30_RS05695	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS05700	COG1177	transmembrane transport
C4K30_RS05705	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K30_RS05710	COG3842	ATPase activity
C4K30_RS05715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4K30_RS05720	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS05725	COG0583	DNA-binding transcription factor activity
C4K30_RS05735	COG0840	transmembrane signaling receptor activity
C4K30_RS05745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K30_RS05745	COG0457	Tetratricopeptide repeat
C4K30_RS05760	COG2201	protein-glutamate methylesterase activity
C4K30_RS05765	COG4251	negative regulation of phosphorylation
C4K30_RS05765	COG5001	Diguanylate cyclase
C4K30_RS05765	COG2203	Gaf domain
C4K30_RS05765	COG3706	GGDEF domain
C4K30_RS05775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4K30_RS05795	COG1073	alpha beta
C4K30_RS05820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4K30_RS05825	COG0563	adenylate kinase activity
C4K30_RS05840	COG1801	Protein of unknown function DUF72
C4K30_RS05855	COG0742	ribosomal rna small subunit methyltransferase
C4K30_RS05865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS05885	COG2937	Belongs to the GPAT DAPAT family
C4K30_RS05900	COG2226	methyltransferase
C4K30_RS05905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K30_RS05915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4K30_RS05925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K30_RS05930	COG2171	N-acyltransferase activity
C4K30_RS05935	COG1393	Belongs to the ArsC family
C4K30_RS05940	COG0025	NhaP-type Na H and K H
C4K30_RS05945	COG0436	Aminotransferase
C4K30_RS05950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4K30_RS05955	COG0024	Methionine aminopeptidase
C4K30_RS05960	COG0052	Belongs to the universal ribosomal protein uS2 family
C4K30_RS05965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4K30_RS05970	COG0528	UMP kinase activity
C4K30_RS05975	COG0233	cytoplasmic translational termination
C4K30_RS05980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4K30_RS05990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4K30_RS06010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K30_RS06015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K30_RS06020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K30_RS06025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K30_RS06030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4K30_RS06035	COG0587	DNA-directed DNA polymerase activity
C4K30_RS06040	COG0825	malonyl-CoA metabolic process
C4K30_RS06045	COG0037	tRNA processing
C4K30_RS06050	COG0504	CTP synthase activity
C4K30_RS06055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4K30_RS06060	COG0148	phosphopyruvate hydratase activity
C4K30_RS06070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4K30_RS06080	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4K30_RS06085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4K30_RS06090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4K30_RS06095	COG0585	pseudouridine synthase activity
C4K30_RS06100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4K30_RS06105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4K30_RS06125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4K30_RS06150	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K30_RS06260	COG4386	tail sheath protein
C4K30_RS06295	COG4381	Mu-like prophage protein gp46
C4K30_RS06345	COG3179	chitinase
C4K30_RS06355	COG1546	Belongs to the CinA family
C4K30_RS06360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4K30_RS06365	COG2137	regulation of response to DNA damage stimulus
C4K30_RS06385	COG3148	PFAM DTW domain containing protein
C4K30_RS06400	COG0583	DNA-binding transcription factor activity
C4K30_RS06420	COG4807	Protein conserved in bacteria
C4K30_RS06425	COG1187	pseudouridine synthase activity
C4K30_RS06435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K30_RS06445	COG3158	transport of potassium into the cell
C4K30_RS06470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4K30_RS06480	COG0442	prolyl-tRNA aminoacylation
C4K30_RS06505	COG1278	Cold shock
C4K30_RS06510	COG0717	Belongs to the dCTP deaminase family
C4K30_RS06535	COG4215	(ABC) transporter
C4K30_RS06545	COG2366	antibiotic biosynthetic process
C4K30_RS06550	COG0625	glutathione transferase activity
C4K30_RS06560	COG0653	protein targeting
C4K30_RS06570	COG3012	SEC-C Motif Domain Protein
C4K30_RS06605	COG1199	ATP-dependent helicase activity
C4K30_RS06620	COG2885	chlorophyll binding
C4K30_RS06625	COG0259	pyridoxamine-phosphate oxidase activity
C4K30_RS06640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K30_RS06650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4K30_RS06665	COG0583	DNA-binding transcription factor activity
C4K30_RS06680	COG3220	belongs to the UPF0276 family
C4K30_RS06725	COG2084	Dehydrogenase
C4K30_RS06735	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4K30_RS06740	COG2271	Major facilitator Superfamily
C4K30_RS06745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K30_RS06755	COG0306	phosphate transporter
C4K30_RS06765	COG1414	Transcriptional regulator
C4K30_RS06770	COG2814	Major facilitator Superfamily
C4K30_RS06775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K30_RS06780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4K30_RS06785	COG0183	Belongs to the thiolase family
C4K30_RS06790	COG3485	protocatechuate 3,4-dioxygenase
C4K30_RS06795	COG3485	protocatechuate 3,4-dioxygenase
C4K30_RS06800	COG0477	Major facilitator Superfamily
C4K30_RS06810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K30_RS06815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K30_RS06835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS06850	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS06855	COG2814	Major facilitator Superfamily
C4K30_RS06895	COG1473	amidohydrolase
C4K30_RS06905	COG0154	amidase activity
C4K30_RS06930	COG1704	LemA family
C4K30_RS06935	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4K30_RS06950	COG0697	spore germination
C4K30_RS06955	COG0693	protein deglycase activity
C4K30_RS06970	COG2188	Transcriptional regulator
C4K30_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS07015	COG1629	transport
C4K30_RS07025	COG1595	DNA-templated transcription, initiation
C4K30_RS07030	COG3422	double-strand break repair
C4K30_RS07035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K30_RS07040	COG0235	Class ii aldolase
C4K30_RS07045	COG1396	sequence-specific DNA binding
C4K30_RS07055	COG1454	alcohol dehydrogenase
C4K30_RS07140	COG3938	Belongs to the proline racemase family
C4K30_RS07145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K30_RS07150	COG0531	amino acid
C4K30_RS07160	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4K30_RS07185	COG0583	DNA-binding transcription factor activity
C4K30_RS07190	COG5001	Diguanylate cyclase
C4K30_RS07220	COG2267	carboxylic ester hydrolase activity
C4K30_RS07250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4K30_RS07300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4K30_RS07330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4K30_RS07340	COG0425	Belongs to the sulfur carrier protein TusA family
C4K30_RS07350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4K30_RS07365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4K30_RS07370	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4K30_RS07375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K30_RS07380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4K30_RS07400	COG2197	response regulator
C4K30_RS07410	COG3121	Chaperone
C4K30_RS07415	COG3188	usher protein
C4K30_RS07420	COG3121	Chaperone
C4K30_RS07430	COG3210	domain, Protein
C4K30_RS07460	COG2807	transmembrane transport
C4K30_RS07465	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4K30_RS07475	COG0583	DNA-binding transcription factor activity
C4K30_RS07485	COG2194	sulfuric ester hydrolase activity
C4K30_RS07500	COG3100	YcgL domain-containing protein
C4K30_RS07515	COG2983	Belongs to the UPF0260 family
C4K30_RS07565	COG0121	glutamine amidotransferase
C4K30_RS07575	COG0583	DNA-binding transcription factor activity
C4K30_RS07580	COG2814	Major facilitator Superfamily
C4K30_RS07585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K30_RS07590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4K30_RS07595	COG1984	allophanate hydrolase subunit 2
C4K30_RS07605	COG0542	response to heat
C4K30_RS07615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4K30_RS07645	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4K30_RS07650	COG1643	Atp-dependent helicase
C4K30_RS07660	COG1595	DNA-templated transcription, initiation
C4K30_RS07695	COG0814	amino acid
C4K30_RS07730	COG0477	Major facilitator Superfamily
C4K30_RS07735	COG0583	DNA-binding transcription factor activity
C4K30_RS07745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4K30_RS07750	COG1132	(ABC) transporter
C4K30_RS07775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K30_RS07785	COG0668	transmembrane transport
C4K30_RS07790	COG0513	Belongs to the DEAD box helicase family
C4K30_RS07840	COG0697	spore germination
C4K30_RS07850	COG0583	DNA-binding transcription factor activity
C4K30_RS07860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K30_RS07865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K30_RS07895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS07920	COG5001	Diguanylate cyclase
C4K30_RS07920	COG5002	protein histidine kinase activity
C4K30_RS07930	COG2832	Protein of unknown function (DUF454)
C4K30_RS07955	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4K30_RS07970	COG2207	Transcriptional regulator
C4K30_RS07995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4K30_RS08015	COG0745	RESPONSE REGULATOR receiver
C4K30_RS08025	COG2350	Protein conserved in bacteria
C4K30_RS08030	COG2917	probably involved in intracellular septation
C4K30_RS08035	COG0613	PHP domain protein
C4K30_RS08040	COG0009	L-threonylcarbamoyladenylate synthase
C4K30_RS08050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4K30_RS08070	COG1113	amino acid transport
C4K30_RS08095	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4K30_RS08110	COG4786	Flagellar basal body rod
C4K30_RS08120	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4K30_RS08125	COG1706	bacterial-type flagellum-dependent cell motility
C4K30_RS08135	COG1256	bacterial-type flagellum assembly
C4K30_RS08145	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS08145	COG1216	Glycosyl transferase, family 2
C4K30_RS08150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K30_RS08185	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS08185	COG1216	Glycosyl transferase, family 2
C4K30_RS08190	COG1086	Polysaccharide biosynthesis protein
C4K30_RS08195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K30_RS08200	COG1083	cytidylyl-transferase
C4K30_RS08210	COG2089	acid synthase
C4K30_RS08215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4K30_RS08240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4K30_RS08270	COG1677	Flagellar hook-basal body complex protein FliE
C4K30_RS08305	COG0745	RESPONSE REGULATOR receiver
C4K30_RS08385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4K30_RS08390	COG2198	Histidine kinase
C4K30_RS08390	COG0784	Response regulator, receiver
C4K30_RS08390	COG0643	Histidine kinase
C4K30_RS08395	COG2201	protein-glutamate methylesterase activity
C4K30_RS08400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4K30_RS08410	COG1192	Involved in chromosome partitioning
C4K30_RS08420	COG0835	chemotaxis
C4K30_RS08440	COG4133	protoheme IX ABC transporter activity
C4K30_RS08460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4K30_RS08465	COG1138	Cytochrome C-type biogenesis protein
C4K30_RS08475	COG3088	subunit of a heme lyase
C4K30_RS08495	COG0583	DNA-binding transcription factor activity
C4K30_RS08500	COG2814	Major facilitator Superfamily
C4K30_RS08520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K30_RS08525	COG4413	Urea transporter
C4K30_RS08530	COG0469	pyruvate kinase activity
C4K30_RS08540	COG2084	Dehydrogenase
C4K30_RS08545	COG3622	Belongs to the hyi family
C4K30_RS08550	COG3960	tartronate-semialdehyde synthase activity
C4K30_RS08560	COG1309	transcriptional regulator
C4K30_RS08565	COG2354	Protein conserved in bacteria
C4K30_RS08570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K30_RS08585	COG1834	amidinotransferase
C4K30_RS08595	COG2192	nodulation
C4K30_RS08600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4K30_RS08625	COG2853	Lipoprotein
C4K30_RS08645	COG2113	Glycine betaine
C4K30_RS08650	COG3162	membrane
C4K30_RS08655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4K30_RS08665	COG2009	succinate dehydrogenase
C4K30_RS08670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4K30_RS08675	COG1053	succinate dehydrogenase
C4K30_RS08695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K30_RS08700	COG0045	succinate-CoA ligase (ADP-forming) activity
C4K30_RS08740	COG0326	Molecular chaperone. Has ATPase activity
C4K30_RS08750	COG0626	cystathionine gamma-synthase activity
C4K30_RS08760	COG1741	Belongs to the pirin family
C4K30_RS08785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4K30_RS08800	COG4771	TonB-dependent receptor
C4K30_RS08805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4K30_RS08815	COG2062	phosphohistidine phosphatase, SixA
C4K30_RS08820	COG1022	Amp-dependent synthetase and ligase
C4K30_RS08840	COG0625	glutathione transferase activity
C4K30_RS08850	COG0628	permease
C4K30_RS08870	COG0284	orotidine-5'-phosphate decarboxylase activity
C4K30_RS08875	COG2130	NADP-dependent
C4K30_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS08885	COG0840	transmembrane signaling receptor activity
C4K30_RS08915	COG2814	Major facilitator Superfamily
C4K30_RS08925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS08925	COG2205	protein histidine kinase activity
C4K30_RS08945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K30_RS08960	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS08970	COG0625	glutathione transferase activity
C4K30_RS08975	COG1131	(ABC) transporter
C4K30_RS08980	COG0842	Transport permease protein
C4K30_RS08995	COG0811	peptide transport
C4K30_RS09000	COG0848	biopolymer transport protein
C4K30_RS09005	COG1663	tetraacyldisaccharide 4'-kinase activity
C4K30_RS09010	COG2835	tetraacyldisaccharide 4'-kinase activity
C4K30_RS09015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4K30_RS09020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4K30_RS09025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4K30_RS09035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K30_RS09040	COG3608	succinylglutamate desuccinylase aspartoacylase
C4K30_RS09040	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4K30_RS09050	COG1530	ribonuclease E activity
C4K30_RS09060	COG0546	phosphoglycolate phosphatase activity
C4K30_RS09065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K30_RS09065	COG0616	signal peptide processing
C4K30_RS09070	COG0424	maF-like protein
C4K30_RS09080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4K30_RS09085	COG0416	fatty acid biosynthetic process
C4K30_RS09100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS09105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K30_RS09115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4K30_RS09120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4K30_RS09130	COG0084	hydrolase, TatD family'
C4K30_RS09145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K30_RS09160	COG2188	Transcriptional regulator
C4K30_RS09165	COG1397	ADP-ribosylglycohydrolase
C4K30_RS09175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K30_RS09190	COG1418	mRNA catabolic process
C4K30_RS09200	COG1064	alcohol dehydrogenase
C4K30_RS09205	COG2207	Transcriptional regulator
C4K30_RS09235	COG3047	cAMP biosynthetic process
C4K30_RS09235	COG2885	chlorophyll binding
C4K30_RS09240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K30_RS09275	COG0183	Belongs to the thiolase family
C4K30_RS09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS09280	COG1024	Enoyl-CoA hydratase
C4K30_RS09285	COG0519	Catalyzes the synthesis of GMP from XMP
C4K30_RS09285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K30_RS09290	COG0583	DNA-binding transcription factor activity
C4K30_RS09300	COG0598	Magnesium transport protein CorA
C4K30_RS09305	COG0204	Acyl-transferase
C4K30_RS09355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K30_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS09365	COG0583	DNA-binding transcription factor activity
C4K30_RS09375	COG1953	Uracil, thiamine, allantoin
C4K30_RS09385	COG0560	Phosphoserine phosphatase
C4K30_RS09405	COG0189	ligase activity
C4K30_RS09405	COG4067	protein conserved in archaea
C4K30_RS09410	COG1802	Transcriptional regulator
C4K30_RS09420	COG0372	Belongs to the citrate synthase family
C4K30_RS09435	COG2079	MmgE PrpD family protein
C4K30_RS09440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4K30_RS09455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K30_RS09470	COG0668	transmembrane transport
C4K30_RS09480	COG3047	cAMP biosynthetic process
C4K30_RS09480	COG2885	chlorophyll binding
C4K30_RS09485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K30_RS09490	COG0243	molybdopterin cofactor binding
C4K30_RS09495	COG2146	nitrite reductase [NAD(P)H] activity
C4K30_RS09500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K30_RS09505	COG2815	serine threonine protein kinase
C4K30_RS09505	COG0515	serine threonine protein kinase
C4K30_RS09510	COG2223	nitrite transmembrane transporter activity
C4K30_RS09515	COG3707	response regulator
C4K30_RS09520	COG1116	anion transmembrane transporter activity
C4K30_RS09520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS09525	COG0167	dihydroorotate dehydrogenase activity
C4K30_RS09530	COG3130	regulation of translation
C4K30_RS09535	COG0116	Belongs to the methyltransferase superfamily
C4K30_RS09535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K30_RS09545	COG2027	D-alanyl-D-alanine carboxypeptidase
C4K30_RS09550	COG3171	Protein conserved in bacteria
C4K30_RS09555	COG3135	benzoate transporter
C4K30_RS09560	COG1802	Transcriptional regulator
C4K30_RS09565	COG0402	S-adenosylhomocysteine deaminase activity
C4K30_RS09590	COG1196	nuclear chromosome segregation
C4K30_RS09595	COG3115	cell septum assembly
C4K30_RS09600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4K30_RS09655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4K30_RS09660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4K30_RS09665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4K30_RS09670	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS09675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K30_RS09680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K30_RS09700	COG2217	Heavy metal translocating P-type atpase
C4K30_RS09710	COG0348	domain, Protein
C4K30_RS09725	COG2010	Cytochrome c
C4K30_RS09740	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K30_RS09745	COG2010	Cytochrome c
C4K30_RS09760	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K30_RS09770	COG0840	transmembrane signaling receptor activity
C4K30_RS09785	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4K30_RS09790	COG0425	Belongs to the sulfur carrier protein TusA family
C4K30_RS09800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K30_RS09810	COG1132	(ABC) transporter
C4K30_RS09815	COG0741	lytic transglycosylase activity
C4K30_RS09820	COG0488	(ABC) transporter
C4K30_RS09825	COG0589	response to stress
C4K30_RS09840	COG1024	Enoyl-CoA hydratase
C4K30_RS09840	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS09845	COG0183	Belongs to the thiolase family
C4K30_RS09895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K30_RS09900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K30_RS09910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4K30_RS09925	COG1477	protein flavinylation
C4K30_RS09930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K30_RS09935	COG0584	glycerophosphoryl diester phosphodiesterase
C4K30_RS09945	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K30_RS09950	COG1136	(ABC) transporter
C4K30_RS09955	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4K30_RS09975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K30_RS09975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4K30_RS09985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K30_RS09990	COG2853	Lipoprotein
C4K30_RS10000	COG2204	response regulator
C4K30_RS10010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4K30_RS10015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K30_RS10130	COG0616	signal peptide processing
C4K30_RS10240	COG3179	chitinase
C4K30_RS10260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K30_RS10265	COG0583	DNA-binding transcription factor activity
C4K30_RS10275	COG2203	Gaf domain
C4K30_RS10275	COG5001	Diguanylate cyclase
C4K30_RS10275	COG3706	GGDEF domain
C4K30_RS10275	COG4251	negative regulation of phosphorylation
C4K30_RS10295	COG2233	PERMEase
C4K30_RS10325	COG0556	nucleotide-excision repair
C4K30_RS10330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K30_RS10360	COG0596	Alpha beta hydrolase
C4K30_RS10370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4K30_RS10385	COG2214	Heat shock protein DnaJ domain protein
C4K30_RS10390	COG0443	Heat shock 70 kDa protein
C4K30_RS10405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4K30_RS10410	COG0066	3-isopropylmalate dehydratase activity
C4K30_RS10415	COG0473	3-isopropylmalate dehydrogenase activity
C4K30_RS10445	COG0135	phosphoribosylanthranilate isomerase activity
C4K30_RS10450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4K30_RS10455	COG0285	dihydrofolate synthase activity
C4K30_RS10460	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4K30_RS10465	COG1286	toxin biosynthetic process
C4K30_RS10500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS10535	COG3397	chitin binding
C4K30_RS10540	COG3469	chitinase activity
C4K30_RS10555	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K30_RS10585	COG1879	ABC-type sugar transport system periplasmic component
C4K30_RS10590	COG1129	ABC transporter
C4K30_RS10595	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K30_RS10600	COG1609	Transcriptional regulator
C4K30_RS10605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K30_RS10610	COG1869	D-ribose catabolic process
C4K30_RS10635	COG1278	Cold shock
C4K30_RS10645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K30_RS10650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4K30_RS10655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4K30_RS10660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4K30_RS10665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4K30_RS10670	COG0072	phenylalanine-tRNA ligase activity
C4K30_RS10675	COG0776	regulation of translation
C4K30_RS10705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K30_RS10705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS10705	COG3321	synthase
C4K30_RS10705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K30_RS10710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K30_RS10710	COG4221	oxidoreductase activity
C4K30_RS10710	COG3321	synthase
C4K30_RS10710	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS10715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K30_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS10715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K30_RS10715	COG3321	synthase
C4K30_RS10715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS10720	COG4221	oxidoreductase activity
C4K30_RS10720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS10720	COG0300	oxidoreductase activity
C4K30_RS10720	COG3321	synthase
C4K30_RS10725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K30_RS10730	COG0076	glutamate decarboxylase activity
C4K30_RS10735	COG2091	lysine biosynthetic process via aminoadipic acid
C4K30_RS10765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4K30_RS10800	COG1309	transcriptional regulator
C4K30_RS10805	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS10825	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS10830	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS10835	COG4191	Histidine kinase
C4K30_RS10840	COG4566	intracellular signal transduction
C4K30_RS10850	COG1598	PFAM Uncharacterised protein family UPF0150
C4K30_RS10880	COG0450	alkyl hydroperoxide reductase
C4K30_RS10910	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K30_RS10915	COG3657	addiction module killer protein
C4K30_RS10920	COG5383	Protein conserved in bacteria
C4K30_RS10925	COG3706	GGDEF domain
C4K30_RS10950	COG0531	amino acid
C4K30_RS10975	COG0583	DNA-binding transcription factor activity
C4K30_RS11040	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4K30_RS11045	COG0247	lactate metabolic process
C4K30_RS11050	COG0277	FAD linked oxidase domain protein
C4K30_RS11055	COG0277	FAD linked oxidase domain protein
C4K30_RS11065	COG2186	Transcriptional regulator
C4K30_RS11095	COG1063	alcohol dehydrogenase
C4K30_RS11110	COG0709	Synthesizes selenophosphate from selenide and ATP
C4K30_RS11115	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4K30_RS11120	COG0701	Predicted permease
C4K30_RS11125	COG1414	Transcriptional regulator
C4K30_RS11130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS11135	COG0765	amino acid transport
C4K30_RS11140	COG1126	abc transporter atp-binding protein
C4K30_RS11145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS11155	COG0625	glutathione transferase activity
C4K30_RS11160	COG0384	phenazine biosynthesis protein PhzF
C4K30_RS11175	COG0248	Ppx GppA phosphatase
C4K30_RS11205	COG0019	diaminopimelate decarboxylase activity
C4K30_RS11240	COG0071	Belongs to the small heat shock protein (HSP20) family
C4K30_RS11245	COG0113	porphobilinogen synthase activity
C4K30_RS11285	COG4650	regulator
C4K30_RS11295	COG1690	Belongs to the RtcB family
C4K30_RS11305	COG3541	Predicted nucleotidyltransferase
C4K30_RS11310	COG0430	RNA-3'-phosphate cyclase activity
C4K30_RS11340	COG0583	DNA-binding transcription factor activity
C4K30_RS11365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4K30_RS11370	COG0583	DNA-binding transcription factor activity
C4K30_RS11375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4K30_RS11385	COG3180	Ammonia monooxygenase
C4K30_RS11390	COG0583	DNA-binding transcription factor activity
C4K30_RS11400	COG3609	addiction module antidote protein, CC2985 family
C4K30_RS11405	COG0517	IMP dehydrogenase activity
C4K30_RS11425	COG1177	transmembrane transport
C4K30_RS11430	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K30_RS11435	COG3842	ATPase activity
C4K30_RS11440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K30_RS11445	COG0174	glutamine synthetase
C4K30_RS11450	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS11455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS11460	COG1396	sequence-specific DNA binding
C4K30_RS11460	COG1917	Cupin 2, conserved barrel domain protein
C4K30_RS11500	COG1595	DNA-templated transcription, initiation
C4K30_RS11505	COG3712	iron ion homeostasis
C4K30_RS11510	COG4772	TonB-dependent receptor
C4K30_RS11515	COG0583	DNA-binding transcription factor activity
C4K30_RS11520	COG2814	Major facilitator Superfamily
C4K30_RS11525	COG2384	SAM-dependent methyltransferase
C4K30_RS11530	COG1944	ATP diphosphatase activity
C4K30_RS11590	COG2223	nitrite transmembrane transporter activity
C4K30_RS11605	COG0697	spore germination
C4K30_RS11610	COG0583	DNA-binding transcription factor activity
C4K30_RS11620	COG0697	spore germination
C4K30_RS11625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K30_RS11635	COG0659	secondary active sulfate transmembrane transporter activity
C4K30_RS11645	COG1999	signal sequence binding
C4K30_RS11660	COG0583	DNA-binding transcription factor activity
C4K30_RS11665	COG3048	D-serine ammonia-lyase activity
C4K30_RS11670	COG2610	gluconate transmembrane transporter activity
C4K30_RS11675	COG0251	oxidation-reduction process
C4K30_RS11685	COG0688	phosphatidylethanolamine metabolic process
C4K30_RS11700	COG2207	Transcriptional regulator
C4K30_RS11700	COG1917	Cupin 2, conserved barrel domain protein
C4K30_RS11720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K30_RS11750	COG0826	peptidase U32
C4K30_RS11770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS11785	COG2207	Transcriptional regulator
C4K30_RS11795	COG0583	DNA-binding transcription factor activity
C4K30_RS11805	COG1301	dicarboxylic acid transport
C4K30_RS11855	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K30_RS11865	COG1611	Belongs to the LOG family
C4K30_RS11880	COG2204	response regulator
C4K30_RS11885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4K30_RS11895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K30_RS11915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS11920	COG0174	glutamine synthetase
C4K30_RS11935	COG1335	isochorismatase
C4K30_RS11940	COG3224	Antibiotic biosynthesis monooxygenase
C4K30_RS11955	COG0417	DNA replication proofreading
C4K30_RS11970	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K30_RS11985	COG0477	Major facilitator Superfamily
C4K30_RS12005	COG4319	ketosteroid isomerase
C4K30_RS12010	COG4335	DNA alkylation repair
C4K30_RS12020	COG0501	Belongs to the peptidase M48B family
C4K30_RS12025	COG1704	LemA family
C4K30_RS12030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4K30_RS12080	COG2267	carboxylic ester hydrolase activity
C4K30_RS12095	COG0640	Transcriptional regulator
C4K30_RS12110	COG2308	Evidence 4 Homologs of previously reported genes of
C4K30_RS12120	COG1305	Transglutaminase-like
C4K30_RS12125	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4K30_RS12130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4K30_RS12135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K30_RS12145	COG0022	dehydrogenase e1 component
C4K30_RS12150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4K30_RS12155	COG1522	sequence-specific DNA binding
C4K30_RS12165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K30_RS12185	COG2372	response to copper ion
C4K30_RS12195	COG1309	transcriptional regulator
C4K30_RS12205	COG0493	'glutamate synthase
C4K30_RS12215	COG1953	Uracil, thiamine, allantoin
C4K30_RS12225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS12230	COG0517	IMP dehydrogenase activity
C4K30_RS12230	COG4175	Glycine betaine
C4K30_RS12240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K30_RS12255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS12270	COG0495	leucyl-tRNA aminoacylation
C4K30_RS12325	COG1595	DNA-templated transcription, initiation
C4K30_RS12370	COG1715	Restriction endonuclease
C4K30_RS12385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4K30_RS12415	COG2391	methyltransferase activity
C4K30_RS12465	COG3237	CsbD-like
C4K30_RS12480	COG0745	RESPONSE REGULATOR receiver
C4K30_RS12495	COG3383	formate dehydrogenase (NAD+) activity
C4K30_RS12500	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K30_RS12505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS12545	COG3718	enzyme involved in inositol metabolism
C4K30_RS12560	COG3962	Belongs to the TPP enzyme family
C4K30_RS12565	COG0673	inositol 2-dehydrogenase activity
C4K30_RS12575	COG1082	Xylose isomerase domain protein TIM barrel
C4K30_RS12580	COG0673	inositol 2-dehydrogenase activity
C4K30_RS12595	COG1129	ABC transporter
C4K30_RS12600	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4K30_RS12610	COG0840	transmembrane signaling receptor activity
C4K30_RS12645	COG4774	siderophore transport
C4K30_RS12660	COG1320	monovalent cation:proton antiporter activity
C4K30_RS12665	COG2212	antiporter activity
C4K30_RS12675	COG0651	ATP synthesis coupled electron transport
C4K30_RS12680	COG1006	Multisubunit Na H antiporter MnhC subunit
C4K30_RS12685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4K30_RS12685	COG2111	Na H antiporter
C4K30_RS12750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K30_RS12755	COG0673	inositol 2-dehydrogenase activity
C4K30_RS12765	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS12775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K30_RS12780	COG1335	isochorismatase
C4K30_RS12795	COG3383	formate dehydrogenase (NAD+) activity
C4K30_RS12805	COG0814	amino acid
C4K30_RS12825	COG0589	response to stress
C4K30_RS12835	COG0745	RESPONSE REGULATOR receiver
C4K30_RS12840	COG2205	protein histidine kinase activity
C4K30_RS12855	COG3791	Glutathione-dependent formaldehyde-activating
C4K30_RS12870	COG0583	DNA-binding transcription factor activity
C4K30_RS12875	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4K30_RS12880	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS12885	COG2079	MmgE PrpD family protein
C4K30_RS12930	COG0431	NADPH-dependent FMN reductase
C4K30_RS12990	COG2271	Major facilitator Superfamily
C4K30_RS12995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K30_RS13120	COG1522	sequence-specific DNA binding
C4K30_RS13140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS13145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS13165	COG0596	Alpha beta hydrolase
C4K30_RS13195	COG3064	Membrane
C4K30_RS13250	COG2080	2 iron, 2 sulfur cluster binding
C4K30_RS13255	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4K30_RS13260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K30_RS13265	COG1280	lysine exporter protein (LysE YggA)
C4K30_RS13305	COG1566	PFAM secretion protein HlyD family protein
C4K30_RS13315	COG2828	Protein conserved in bacteria
C4K30_RS13320	COG2207	Transcriptional regulator
C4K30_RS13335	COG3153	acetyltransferase
C4K30_RS13345	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS13345	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K30_RS13375	COG0833	amino acid
C4K30_RS13380	COG1024	Enoyl-CoA hydratase
C4K30_RS13385	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS13410	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4K30_RS13415	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4K30_RS13460	COG2084	Dehydrogenase
C4K30_RS13465	COG3395	kinase activity
C4K30_RS13470	COG0235	Class ii aldolase
C4K30_RS13475	COG2610	gluconate transmembrane transporter activity
C4K30_RS13480	COG3622	Belongs to the hyi family
C4K30_RS13490	COG1349	DNA-binding transcription factor activity
C4K30_RS13590	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS13605	COG2200	EAL domain
C4K30_RS13605	COG2202	Pas domain
C4K30_RS13605	COG2199	diguanylate cyclase activity
C4K30_RS13610	COG0833	amino acid
C4K30_RS13615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS13620	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4K30_RS13635	COG0494	nUDIX hydrolase
C4K30_RS13645	COG3220	belongs to the UPF0276 family
C4K30_RS13655	COG2259	Doxx family
C4K30_RS13665	COG2205	protein histidine kinase activity
C4K30_RS13705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4K30_RS13710	COG1280	lysine exporter protein (LysE YggA)
C4K30_RS13725	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4K30_RS13745	COG0754	glutathionylspermidine amidase activity
C4K30_RS13755	COG3766	membrane
C4K30_RS13775	COG1842	Phage shock protein A
C4K30_RS13815	COG0583	DNA-binding transcription factor activity
C4K30_RS13820	COG0300	oxidoreductase activity
C4K30_RS13855	COG4172	Belongs to the ABC transporter superfamily
C4K30_RS13860	COG4239	(ABC) transporter, permease
C4K30_RS13865	COG4174	ABC transporter (Permease)
C4K30_RS13870	COG4166	transmembrane transport
C4K30_RS13875	COG4166	transmembrane transport
C4K30_RS13880	COG0741	lytic transglycosylase activity
C4K30_RS13880	COG1388	LysM domain
C4K30_RS13885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K30_RS13895	COG0328	RNA-DNA hybrid ribonuclease activity
C4K30_RS13910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K30_RS13935	COG0431	NADPH-dependent FMN reductase
C4K30_RS13940	COG0640	Transcriptional regulator
C4K30_RS13955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4K30_RS13960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K30_RS13970	COG3139	Protein of unknown function (DUF1315)
C4K30_RS13980	COG0308	aminopeptidase N
C4K30_RS13985	COG0659	secondary active sulfate transmembrane transporter activity
C4K30_RS14005	COG2706	6-phosphogluconolactonase activity
C4K30_RS14035	COG0420	3'-5' exonuclease activity
C4K30_RS14100	COG0714	Associated with various cellular activities
C4K30_RS14105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K30_RS14110	COG0477	Major facilitator Superfamily
C4K30_RS14115	COG0579	oxidoreductase
C4K30_RS14120	COG2186	Transcriptional regulator
C4K30_RS14135	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS14170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K30_RS14175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K30_RS14355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K30_RS14370	COG1794	racemase activity, acting on amino acids and derivatives
C4K30_RS14390	COG3278	Belongs to the heme-copper respiratory oxidase family
C4K30_RS14400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K30_RS14435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS14440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS14445	COG1538	Outer membrane efflux protein
C4K30_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS14460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K30_RS14465	COG0348	domain, Protein
C4K30_RS14490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K30_RS14505	COG3568	Endonuclease Exonuclease Phosphatase
C4K30_RS14530	COG1640	4-alpha-glucanotransferase
C4K30_RS14535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4K30_RS14540	COG0297	glycogen (starch) synthase activity
C4K30_RS14545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K30_RS14555	COG1238	metal cluster binding
C4K30_RS14605	COG2366	antibiotic biosynthetic process
C4K30_RS14645	COG0583	DNA-binding transcription factor activity
C4K30_RS14660	COG0583	DNA-binding transcription factor activity
C4K30_RS14665	COG2066	Belongs to the glutaminase family
C4K30_RS14675	COG2233	PERMEase
C4K30_RS14685	COG0010	Belongs to the arginase family
C4K30_RS14700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K30_RS14735	COG2194	sulfuric ester hydrolase activity
C4K30_RS14740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4K30_RS14745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4K30_RS14750	COG0561	phosphatase activity
C4K30_RS14755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4K30_RS14760	COG2030	dehydratase
C4K30_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS14775	COG3162	membrane
C4K30_RS14780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K30_RS14785	COG2151	metal-sulfur cluster biosynthetic enzyme
C4K30_RS14790	COG3396	Phenylacetate-CoA oxygenase
C4K30_RS14795	COG3460	Phenylacetate-CoA oxygenase
C4K30_RS14800	COG3396	Phenylacetate-CoA oxygenase
C4K30_RS14810	COG0183	Belongs to the thiolase family
C4K30_RS14820	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS14825	COG1024	Enoyl-CoA hydratase
C4K30_RS14830	COG1024	Enoyl-CoA hydratase
C4K30_RS14840	COG3327	negative regulation of DNA-templated transcription, initiation
C4K30_RS14850	COG2204	response regulator
C4K30_RS14895	COG0840	transmembrane signaling receptor activity
C4K30_RS14900	COG1968	undecaprenyl-diphosphatase activity
C4K30_RS14920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4K30_RS14935	COG0488	(ABC) transporter
C4K30_RS14950	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4K30_RS14960	COG2133	pyrroloquinoline quinone binding
C4K30_RS14970	COG0189	ligase activity
C4K30_RS14975	COG0598	Magnesium transport protein CorA
C4K30_RS14980	COG0024	Methionine aminopeptidase
C4K30_RS14995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K30_RS15000	COG4574	serine-type endopeptidase inhibitor activity
C4K30_RS15080	COG0726	polysaccharide deacetylase
C4K30_RS15150	COG1070	Carbohydrate kinase
C4K30_RS15170	COG1175	transmembrane transport
C4K30_RS15180	COG4774	siderophore transport
C4K30_RS15185	COG2207	Transcriptional regulator
C4K30_RS15190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K30_RS15200	COG0183	Belongs to the thiolase family
C4K30_RS15205	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS15210	COG1024	Enoyl-CoA hydratase
C4K30_RS15215	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS15220	COG1024	Enoyl-CoA hydratase
C4K30_RS15230	COG0463	Glycosyl transferase, family 2
C4K30_RS15250	COG2814	Major facilitator Superfamily
C4K30_RS15280	COG0765	amino acid transport
C4K30_RS15285	COG0165	Argininosuccinate lyase
C4K30_RS15310	COG2076	Multidrug Resistance protein
C4K30_RS15315	COG2076	Multidrug Resistance protein
C4K30_RS15320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4K30_RS15325	COG0726	polysaccharide deacetylase
C4K30_RS15330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K30_RS15330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K30_RS15335	COG0463	Glycosyl transferase, family 2
C4K30_RS15340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K30_RS15355	COG1131	(ABC) transporter
C4K30_RS15390	COG0747	negative chemotaxis
C4K30_RS15410	COG0667	Aldo Keto reductase
C4K30_RS15415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4K30_RS15420	COG4172	Belongs to the ABC transporter superfamily
C4K30_RS15450	COG1132	(ABC) transporter
C4K30_RS15455	COG0583	DNA-binding transcription factor activity
C4K30_RS15460	COG1335	isochorismatase
C4K30_RS15465	COG1335	isochorismatase
C4K30_RS15490	COG0765	amino acid transport
C4K30_RS15500	COG0405	Gamma-glutamyltransferase
C4K30_RS15530	COG0589	response to stress
C4K30_RS15560	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS15580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS15585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS15600	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS15600	COG1024	Enoyl-CoA hydratase
C4K30_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS15635	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS15645	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS15650	COG4221	oxidoreductase activity
C4K30_RS15650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS15650	COG3321	synthase
C4K30_RS15650	COG0300	oxidoreductase activity
C4K30_RS15655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS15660	COG1231	oxidoreductase activity
C4K30_RS15675	COG2863	cytochrome
C4K30_RS15695	COG0251	oxidation-reduction process
C4K30_RS15705	COG0745	RESPONSE REGULATOR receiver
C4K30_RS15740	COG3209	COG3209 Rhs family protein
C4K30_RS15760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K30_RS15765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K30_RS15805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K30_RS15810	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C4K30_RS15820	COG3540	Alkaline phosphatase
C4K30_RS15845	COG0811	peptide transport
C4K30_RS15855	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K30_RS15875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K30_RS15885	COG2084	Dehydrogenase
C4K30_RS15895	COG2130	NADP-dependent
C4K30_RS15900	COG1309	transcriptional regulator
C4K30_RS15905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS15910	COG1116	anion transmembrane transporter activity
C4K30_RS15915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS15920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS15930	COG0583	DNA-binding transcription factor activity
C4K30_RS15940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K30_RS15950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS15960	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS15965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K30_RS15985	COG4206	TonB-dependent receptor
C4K30_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS16010	COG0583	DNA-binding transcription factor activity
C4K30_RS16020	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS16025	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C4K30_RS16045	COG3264	Mechanosensitive ion channel
C4K30_RS16045	COG1196	nuclear chromosome segregation
C4K30_RS16050	COG3706	GGDEF domain
C4K30_RS16055	COG0583	DNA-binding transcription factor activity
C4K30_RS16060	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS16100	COG0277	FAD linked oxidase domain protein
C4K30_RS16100	COG0247	lactate metabolic process
C4K30_RS16105	COG0583	DNA-binding transcription factor activity
C4K30_RS16140	COG0494	nUDIX hydrolase
C4K30_RS16150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K30_RS16150	COG2146	nitrite reductase [NAD(P)H] activity
C4K30_RS16155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4K30_RS16155	COG2146	nitrite reductase [NAD(P)H] activity
C4K30_RS16160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4K30_RS16170	COG1120	ATPase activity
C4K30_RS16175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K30_RS16180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K30_RS16185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4K30_RS16190	COG4264	IucA IucC family
C4K30_RS16200	COG4264	IucA IucC family
C4K30_RS16205	COG2814	Major facilitator Superfamily
C4K30_RS16210	COG0019	diaminopimelate decarboxylase activity
C4K30_RS16215	COG4264	IucA IucC family
C4K30_RS16220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K30_RS16225	COG4774	siderophore transport
C4K30_RS16230	COG3712	iron ion homeostasis
C4K30_RS16235	COG1595	DNA-templated transcription, initiation
C4K30_RS16255	COG0174	glutamine synthetase
C4K30_RS16265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS16275	COG2200	EAL domain
C4K30_RS16290	COG3851	Histidine kinase
C4K30_RS16300	COG2205	protein histidine kinase activity
C4K30_RS16300	COG0784	Response regulator, receiver
C4K30_RS16340	COG0589	response to stress
C4K30_RS16345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS16350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS16355	COG1116	anion transmembrane transporter activity
C4K30_RS16370	COG4977	sequence-specific DNA binding
C4K30_RS16370	COG1917	Cupin 2, conserved barrel domain protein
C4K30_RS16375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS16385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS16390	COG1116	anion transmembrane transporter activity
C4K30_RS16410	COG0656	L-ascorbic acid biosynthetic process
C4K30_RS16415	COG2205	protein histidine kinase activity
C4K30_RS16415	COG0784	Response regulator, receiver
C4K30_RS16420	COG3300	MHYT domain
C4K30_RS16420	COG5001	Diguanylate cyclase
C4K30_RS16430	COG2197	response regulator
C4K30_RS16450	COG1199	ATP-dependent helicase activity
C4K30_RS16470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K30_RS16475	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4K30_RS16540	COG0531	amino acid
C4K30_RS16555	COG2909	trisaccharide binding
C4K30_RS16565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K30_RS16570	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS16585	COG5295	Hep Hag repeat protein
C4K30_RS16660	COG2200	EAL domain
C4K30_RS16660	COG2203	Gaf domain
C4K30_RS16660	COG2199	diguanylate cyclase activity
C4K30_RS16665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS16665	COG2205	protein histidine kinase activity
C4K30_RS16670	COG2197	response regulator
C4K30_RS16690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS16705	COG0210	DNA helicase
C4K30_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS16720	COG0604	alcohol dehydrogenase
C4K30_RS16720	COG3321	synthase
C4K30_RS16735	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS16750	COG3469	chitinase activity
C4K30_RS16755	COG3397	chitin binding
C4K30_RS16760	COG0583	DNA-binding transcription factor activity
C4K30_RS16780	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS16800	COG2072	flavoprotein involved in K transport
C4K30_RS16805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS16810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS16815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS16830	COG1566	PFAM secretion protein HlyD family protein
C4K30_RS16855	COG2205	protein histidine kinase activity
C4K30_RS16855	COG2198	Histidine kinase
C4K30_RS16855	COG0784	Response regulator, receiver
C4K30_RS16865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K30_RS16870	COG2198	Histidine kinase
C4K30_RS16870	COG0784	Response regulator, receiver
C4K30_RS16870	COG2205	protein histidine kinase activity
C4K30_RS16890	COG0672	)-iron permease
C4K30_RS16895	COG2822	iron ion transport
C4K30_RS16905	COG2822	iron ion transport
C4K30_RS16910	COG2814	Major facilitator Superfamily
C4K30_RS16915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K30_RS16930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS16945	COG2816	NAD+ diphosphatase activity
C4K30_RS16950	COG1024	Enoyl-CoA hydratase
C4K30_RS16965	COG1335	isochorismatase
C4K30_RS16970	COG2205	protein histidine kinase activity
C4K30_RS16975	COG0745	RESPONSE REGULATOR receiver
C4K30_RS16980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS17015	COG1609	Transcriptional regulator
C4K30_RS17025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4K30_RS17090	COG2814	Major facilitator Superfamily
C4K30_RS17095	COG1063	alcohol dehydrogenase
C4K30_RS17110	COG0456	acetyltransferase
C4K30_RS17110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4K30_RS17135	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS17140	COG3384	dioxygenase
C4K30_RS17150	COG2271	Major facilitator Superfamily
C4K30_RS17155	COG3971	2-oxopent-4-enoate hydratase activity
C4K30_RS17165	COG1929	Belongs to the glycerate kinase type-1 family
C4K30_RS17170	COG3835	regulator
C4K30_RS17175	COG2271	Major facilitator Superfamily
C4K30_RS17180	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS17190	COG0583	DNA-binding transcription factor activity
C4K30_RS17195	COG0667	Aldo Keto reductase
C4K30_RS17205	COG1846	Transcriptional regulator
C4K30_RS17215	COG0697	spore germination
C4K30_RS17220	COG0583	DNA-binding transcription factor activity
C4K30_RS17225	COG2200	EAL domain
C4K30_RS17290	COG3258	Cytochrome c
C4K30_RS17295	COG2863	cytochrome
C4K30_RS17315	COG3145	DNA-N1-methyladenine dioxygenase activity
C4K30_RS17320	COG2169	Transcriptional regulator
C4K30_RS17320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K30_RS17330	COG0604	alcohol dehydrogenase
C4K30_RS17350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4K30_RS17355	COG0488	(ABC) transporter
C4K30_RS17365	COG0393	Putative heavy-metal-binding
C4K30_RS17495	COG3121	Chaperone
C4K30_RS17520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K30_RS17535	COG0583	DNA-binding transcription factor activity
C4K30_RS17555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS17565	COG2205	protein histidine kinase activity
C4K30_RS17570	COG0745	RESPONSE REGULATOR receiver
C4K30_RS17580	COG0300	oxidoreductase activity
C4K30_RS17590	COG0583	DNA-binding transcription factor activity
C4K30_RS17595	COG1309	transcriptional regulator
C4K30_RS17620	COG0475	glutathione-regulated potassium exporter activity
C4K30_RS17625	COG1024	Enoyl-CoA hydratase
C4K30_RS17630	COG0515	serine threonine protein kinase
C4K30_RS17630	COG2815	serine threonine protein kinase
C4K30_RS17640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K30_RS17685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS17690	COG0789	Transcriptional regulator
C4K30_RS17745	COG2181	nitrate reductase activity
C4K30_RS17750	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4K30_RS17755	COG1140	nitrate reductase beta subunit
C4K30_RS17760	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C4K30_RS17765	COG2223	nitrite transmembrane transporter activity
C4K30_RS17775	COG3850	Histidine kinase
C4K30_RS17780	COG2197	response regulator
C4K30_RS17790	COG3154	lipid carrier protein
C4K30_RS17795	COG0826	peptidase U32
C4K30_RS17800	COG0826	peptidase U32
C4K30_RS17805	COG0303	'Molybdopterin
C4K30_RS17810	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K30_RS17825	COG3604	Transcriptional regulator
C4K30_RS17830	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C4K30_RS17845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4K30_RS17860	COG3256	nitric oxide reductase
C4K30_RS17865	COG2010	Cytochrome c
C4K30_RS17875	COG1845	cytochrome c oxidase, subunit III
C4K30_RS17880	COG0714	Associated with various cellular activities
C4K30_RS17895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4K30_RS17900	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K30_RS17920	COG3712	iron ion homeostasis
C4K30_RS17925	COG1595	DNA-templated transcription, initiation
C4K30_RS17930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS17940	COG0861	Integral membrane protein TerC family
C4K30_RS17990	COG2207	Transcriptional regulator
C4K30_RS17995	COG1064	alcohol dehydrogenase
C4K30_RS18035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K30_RS18040	COG1136	(ABC) transporter
C4K30_RS18040	COG0577	efflux transmembrane transporter activity
C4K30_RS18045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS18110	COG2197	response regulator
C4K30_RS18135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4K30_RS18145	COG1136	(ABC) transporter
C4K30_RS18150	COG2815	serine threonine protein kinase
C4K30_RS18150	COG0515	serine threonine protein kinase
C4K30_RS18275	COG0583	DNA-binding transcription factor activity
C4K30_RS18280	COG1335	isochorismatase
C4K30_RS18285	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4K30_RS18305	COG1917	Cupin 2, conserved barrel domain protein
C4K30_RS18305	COG4977	sequence-specific DNA binding
C4K30_RS18335	COG1741	Belongs to the pirin family
C4K30_RS18360	COG1335	isochorismatase
C4K30_RS18370	COG2205	protein histidine kinase activity
C4K30_RS18370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS18380	COG2814	Major facilitator Superfamily
C4K30_RS18415	COG0251	oxidation-reduction process
C4K30_RS18425	COG2186	Transcriptional regulator
C4K30_RS18435	COG2814	Major facilitator Superfamily
C4K30_RS18440	COG2207	Transcriptional regulator
C4K30_RS18445	COG0300	oxidoreductase activity
C4K30_RS18490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS18500	COG1538	Outer membrane efflux protein
C4K30_RS18510	COG2197	response regulator
C4K30_RS18525	COG2205	protein histidine kinase activity
C4K30_RS18525	COG0784	Response regulator, receiver
C4K30_RS18550	COG0322	excinuclease ABC activity
C4K30_RS18555	COG2197	response regulator
C4K30_RS18575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K30_RS18580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4K30_RS18585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K30_RS18590	COG4166	transmembrane transport
C4K30_RS18595	COG4174	ABC transporter (Permease)
C4K30_RS18600	COG4239	(ABC) transporter, permease
C4K30_RS18605	COG4172	Belongs to the ABC transporter superfamily
C4K30_RS18610	COG3604	Transcriptional regulator
C4K30_RS18615	COG2610	gluconate transmembrane transporter activity
C4K30_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS18625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K30_RS18635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K30_RS18680	COG1607	acyl-coa hydrolase
C4K30_RS18685	COG0069	glutamate synthase activity
C4K30_RS18690	COG2026	Addiction module toxin, RelE StbE family
C4K30_RS18720	COG5001	Diguanylate cyclase
C4K30_RS18730	COG0583	DNA-binding transcription factor activity
C4K30_RS18735	COG3437	response regulator, receiver
C4K30_RS18735	COG3850	Histidine kinase
C4K30_RS18735	COG2205	protein histidine kinase activity
C4K30_RS18735	COG4999	Histidine kinase
C4K30_RS18740	COG1538	Outer membrane efflux protein
C4K30_RS18760	COG2274	protein secretion by the type I secretion system
C4K30_RS18765	COG1253	flavin adenine dinucleotide binding
C4K30_RS18770	COG2390	Transcriptional regulator
C4K30_RS18775	COG0698	ribose 5-phosphate isomerase
C4K30_RS18780	COG1129	ABC transporter
C4K30_RS18785	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4K30_RS18790	COG1879	ABC-type sugar transport system periplasmic component
C4K30_RS18795	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS18800	COG1063	alcohol dehydrogenase
C4K30_RS18805	COG2376	Dihydroxyacetone kinase
C4K30_RS18815	COG0583	DNA-binding transcription factor activity
C4K30_RS18835	COG0789	Transcriptional regulator
C4K30_RS18840	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K30_RS18840	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS18890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4K30_RS18890	COG0316	Belongs to the HesB IscA family
C4K30_RS18910	COG1879	ABC-type sugar transport system periplasmic component
C4K30_RS18925	COG0616	signal peptide processing
C4K30_RS18940	COG4172	Belongs to the ABC transporter superfamily
C4K30_RS18945	COG4239	(ABC) transporter, permease
C4K30_RS18950	COG4174	ABC transporter (Permease)
C4K30_RS18955	COG4166	transmembrane transport
C4K30_RS18960	COG4771	TonB-dependent receptor
C4K30_RS18965	COG4206	TonB-dependent receptor
C4K30_RS18970	COG3712	iron ion homeostasis
C4K30_RS18975	COG1595	DNA-templated transcription, initiation
C4K30_RS18980	COG1024	Enoyl-CoA hydratase
C4K30_RS18980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K30_RS19000	COG3189	MarR family transcriptional regulator
C4K30_RS19005	COG2186	Transcriptional regulator
C4K30_RS19045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4K30_RS19075	COG0784	Response regulator, receiver
C4K30_RS19075	COG4191	Histidine kinase
C4K30_RS19080	COG0587	DNA-directed DNA polymerase activity
C4K30_RS19095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K30_RS19115	COG2194	sulfuric ester hydrolase activity
C4K30_RS19135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS19150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4K30_RS19155	COG2188	Transcriptional regulator
C4K30_RS19160	COG0673	inositol 2-dehydrogenase activity
C4K30_RS19220	COG3447	MASE1 domain protein
C4K30_RS19220	COG5001	Diguanylate cyclase
C4K30_RS19220	COG5002	protein histidine kinase activity
C4K30_RS19230	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS19240	COG0303	'Molybdopterin
C4K30_RS19245	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K30_RS19250	COG0746	molybdenum cofactor guanylyltransferase activity
C4K30_RS19255	COG0583	DNA-binding transcription factor activity
C4K30_RS19270	COG0315	cyclic pyranopterin monophosphate synthase activity
C4K30_RS19275	COG3781	membrane
C4K30_RS19280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4K30_RS19290	COG1271	oxidase subunit
C4K30_RS19295	COG1294	oxidase, subunit
C4K30_RS19310	COG0697	spore germination
C4K30_RS19315	COG1522	sequence-specific DNA binding
C4K30_RS19380	COG2989	Protein conserved in bacteria
C4K30_RS19405	COG1858	cytochrome C peroxidase
C4K30_RS19430	COG0579	oxidoreductase
C4K30_RS19475	COG2920	part of a sulfur-relay system
C4K30_RS19480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K30_RS19485	COG0435	Glutathione S-transferase
C4K30_RS19490	COG1648	precorrin-2 dehydrogenase activity
C4K30_RS19490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4K30_RS19495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4K30_RS19500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4K30_RS19505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4K30_RS19510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4K30_RS19515	COG1674	ftsk spoiiie
C4K30_RS19520	COG0492	ferredoxin-NADP+ reductase activity
C4K30_RS19525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4K30_RS19530	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4K30_RS19535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4K30_RS19540	COG0542	response to heat
C4K30_RS19545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4K30_RS19550	COG1278	Cold shock
C4K30_RS19575	COG0482	sulfurtransferase activity
C4K30_RS19580	COG2915	High frequency lysogenization protein hflD homolog
C4K30_RS19590	COG2850	peptidyl-arginine hydroxylation
C4K30_RS19595	COG2153	protein acetylation
C4K30_RS19610	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K30_RS19615	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K30_RS19620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K30_RS19620	COG0649	NAD binding
C4K30_RS19635	COG1034	ATP synthesis coupled electron transport
C4K30_RS19640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4K30_RS19645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4K30_RS19655	COG0713	ATP synthesis coupled electron transport
C4K30_RS19670	COG1007	ATP synthesis coupled electron transport
C4K30_RS19680	COG2944	sequence-specific DNA binding
C4K30_RS19695	COG0395	ABC-type sugar transport system, permease component
C4K30_RS19705	COG3842	ATPase activity
C4K30_RS19710	COG3842	ATPase activity
C4K30_RS19715	COG3284	Transcriptional regulator
C4K30_RS19720	COG0215	cysteine-tRNA ligase activity
C4K30_RS19725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K30_RS19735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4K30_RS19740	COG2814	Major facilitator Superfamily
C4K30_RS19745	COG1566	PFAM secretion protein HlyD family protein
C4K30_RS19755	COG1846	Transcriptional regulator
C4K30_RS19760	COG2911	Protein conserved in bacteria
C4K30_RS19765	COG0729	surface antigen
C4K30_RS19775	COG0708	Exodeoxyribonuclease III
C4K30_RS19785	COG2885	chlorophyll binding
C4K30_RS19790	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS19800	COG0789	Transcriptional regulator
C4K30_RS19815	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS19820	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS19825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K30_RS19840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4K30_RS19850	COG2866	Carboxypeptidase
C4K30_RS19860	COG2814	Major facilitator Superfamily
C4K30_RS19865	COG3038	cytochrome b561
C4K30_RS19920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K30_RS19930	COG0217	transcriptional regulatory protein
C4K30_RS19935	COG0583	DNA-binding transcription factor activity
C4K30_RS19940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4K30_RS19945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K30_RS19950	COG3038	cytochrome b561
C4K30_RS19960	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K30_RS19960	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS19990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K30_RS20000	COG0776	regulation of translation
C4K30_RS20005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K30_RS20010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4K30_RS20015	COG0740	serine-type endopeptidase activity
C4K30_RS20020	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4K30_RS20040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4K30_RS20045	COG1686	Belongs to the peptidase S11 family
C4K30_RS20055	COG1253	flavin adenine dinucleotide binding
C4K30_RS20065	COG0583	DNA-binding transcription factor activity
C4K30_RS20075	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4K30_RS20085	COG3132	Protein of unknown function, DUF480
C4K30_RS20095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K30_RS20115	COG0628	permease
C4K30_RS20120	COG0826	peptidase U32
C4K30_RS20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS20130	COG4215	(ABC) transporter
C4K30_RS20150	COG1737	Transcriptional regulator
C4K30_RS20160	COG2056	Na+-H+ antiporter family
C4K30_RS20165	COG0840	transmembrane signaling receptor activity
C4K30_RS20195	COG0720	synthase
C4K30_RS20200	COG0596	Alpha beta hydrolase
C4K30_RS20210	COG1051	belongs to the nudix hydrolase family
C4K30_RS20215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4K30_RS20220	COG0402	S-adenosylhomocysteine deaminase activity
C4K30_RS20225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K30_RS20240	COG1725	Transcriptional regulator
C4K30_RS20245	COG2207	Transcriptional regulator
C4K30_RS20260	COG0583	DNA-binding transcription factor activity
C4K30_RS20265	COG0583	DNA-binding transcription factor activity
C4K30_RS20275	COG1522	sequence-specific DNA binding
C4K30_RS20290	COG2223	nitrite transmembrane transporter activity
C4K30_RS20295	COG4772	TonB-dependent receptor
C4K30_RS20305	COG1595	DNA-templated transcription, initiation
C4K30_RS20325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS20330	COG2274	protein secretion by the type I secretion system
C4K30_RS20335	COG1538	Outer membrane efflux protein
C4K30_RS20340	COG2080	2 iron, 2 sulfur cluster binding
C4K30_RS20345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K30_RS20345	COG2010	Cytochrome c
C4K30_RS20350	COG2010	Cytochrome c
C4K30_RS20350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4K30_RS20365	COG0840	transmembrane signaling receptor activity
C4K30_RS20370	COG4774	siderophore transport
C4K30_RS20380	COG0300	oxidoreductase activity
C4K30_RS20385	COG3591	Belongs to the peptidase S1B family
C4K30_RS20385	COG1864	DNA RNA non-specific endonuclease
C4K30_RS20405	COG4106	trans-aconitate 2-methyltransferase activity
C4K30_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS20425	COG1942	4-Oxalocrotonate Tautomerase
C4K30_RS20435	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4K30_RS20465	COG2814	Major facilitator Superfamily
C4K30_RS20495	COG3485	protocatechuate 3,4-dioxygenase
C4K30_RS20500	COG4829	muconolactone delta-isomerase
C4K30_RS20505	COG4948	Mandelate Racemase Muconate Lactonizing
C4K30_RS20540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K30_RS20565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4K30_RS20580	COG2814	Major facilitator Superfamily
C4K30_RS20615	COG0154	amidase activity
C4K30_RS20640	COG0583	DNA-binding transcription factor activity
C4K30_RS20650	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS20660	COG1335	isochorismatase
C4K30_RS20685	COG3012	SEC-C Motif Domain Protein
C4K30_RS20685	COG3318	Belongs to the UPF0149 family
C4K30_RS20700	COG0730	response to heat
C4K30_RS20730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4K30_RS20740	COG1335	isochorismatase
C4K30_RS20745	COG1335	isochorismatase
C4K30_RS20755	COG0583	DNA-binding transcription factor activity
C4K30_RS20765	COG0656	L-ascorbic acid biosynthetic process
C4K30_RS20800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS20805	COG1136	(ABC) transporter
C4K30_RS20805	COG0577	efflux transmembrane transporter activity
C4K30_RS20870	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C4K30_RS20880	COG1309	transcriptional regulator
C4K30_RS20890	COG0596	Alpha beta hydrolase
C4K30_RS20895	COG4977	sequence-specific DNA binding
C4K30_RS20960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K30_RS20970	COG0840	transmembrane signaling receptor activity
C4K30_RS21000	COG1132	(ABC) transporter
C4K30_RS21040	COG0583	DNA-binding transcription factor activity
C4K30_RS21090	COG0477	Major facilitator Superfamily
C4K30_RS21095	COG0583	DNA-binding transcription factor activity
C4K30_RS21100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K30_RS21105	COG0235	Class ii aldolase
C4K30_RS21110	COG0477	Major facilitator Superfamily
C4K30_RS21115	COG0583	DNA-binding transcription factor activity
C4K30_RS21120	COG0768	penicillin binding
C4K30_RS21155	COG5006	permease, DMT superfamily
C4K30_RS21165	COG1309	transcriptional regulator
C4K30_RS21170	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS21195	COG0431	NADPH-dependent FMN reductase
C4K30_RS21200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS21210	COG3829	transcription factor binding
C4K30_RS21230	COG2011	ABC-type metal ion transport system permease component
C4K30_RS21270	COG1121	(ABC) transporter
C4K30_RS21275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4K30_RS21285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K30_RS21300	COG0642	Histidine kinase
C4K30_RS21310	COG4232	protein-disulfide reductase activity
C4K30_RS21315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4K30_RS21340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K30_RS21375	COG1309	transcriptional regulator
C4K30_RS21390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4K30_RS21395	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS21400	COG1024	Enoyl-CoA hydratase
C4K30_RS21415	COG3123	guanosine phosphorylase activity
C4K30_RS21420	COG0633	Ferredoxin
C4K30_RS21420	COG3217	Mosc domain protein beta barrel domain protein
C4K30_RS21435	COG3851	Histidine kinase
C4K30_RS21440	COG2197	response regulator
C4K30_RS21445	COG1597	lipid kinase activity
C4K30_RS21460	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4K30_RS21465	COG0746	molybdenum cofactor guanylyltransferase activity
C4K30_RS21475	COG0564	pseudouridine synthase activity
C4K30_RS21500	COG0004	ammonium transporteR
C4K30_RS21520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4K30_RS21540	COG2197	response regulator
C4K30_RS21545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS21545	COG2205	protein histidine kinase activity
C4K30_RS21550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4K30_RS21555	COG1956	GAF domain-containing protein
C4K30_RS21565	COG5002	protein histidine kinase activity
C4K30_RS21565	COG2205	protein histidine kinase activity
C4K30_RS21565	COG0784	Response regulator, receiver
C4K30_RS21570	COG1846	Transcriptional regulator
C4K30_RS21575	COG0386	Belongs to the glutathione peroxidase family
C4K30_RS21580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4K30_RS21585	COG0436	Aminotransferase
C4K30_RS21590	COG0501	Belongs to the peptidase M48B family
C4K30_RS21595	COG0500	methyltransferase
C4K30_RS21600	COG3384	dioxygenase
C4K30_RS21615	COG1024	Enoyl-CoA hydratase
C4K30_RS21625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4K30_RS21630	COG3214	Protein conserved in bacteria
C4K30_RS21640	COG0583	DNA-binding transcription factor activity
C4K30_RS21650	COG0583	DNA-binding transcription factor activity
C4K30_RS21655	COG1846	Transcriptional regulator
C4K30_RS21660	COG1764	response to oxidative stress
C4K30_RS21670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4K30_RS21685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K30_RS21705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4K30_RS21735	COG1376	ErfK ybiS ycfS ynhG family protein
C4K30_RS21750	COG4181	ATPase activity
C4K30_RS21755	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4K30_RS21760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K30_RS21775	COG2197	response regulator
C4K30_RS21785	COG2259	Doxx family
C4K30_RS21790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4K30_RS21830	COG0745	RESPONSE REGULATOR receiver
C4K30_RS21835	COG2205	protein histidine kinase activity
C4K30_RS21840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4K30_RS21850	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4K30_RS21885	COG4221	oxidoreductase activity
C4K30_RS21890	COG1555	photosystem II stabilization
C4K30_RS21890	COG1596	polysaccharide export
C4K30_RS21895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K30_RS21905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K30_RS21910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K30_RS21930	COG0367	asparagine synthase
C4K30_RS21945	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS21955	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4K30_RS21965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4K30_RS21970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4K30_RS21990	COG0776	regulation of translation
C4K30_RS22005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4K30_RS22010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4K30_RS22015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4K30_RS22025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4K30_RS22035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4K30_RS22040	COG0402	S-adenosylhomocysteine deaminase activity
C4K30_RS22045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K30_RS22050	COG0546	phosphoglycolate phosphatase activity
C4K30_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS22070	COG5001	Diguanylate cyclase
C4K30_RS22070	COG5002	protein histidine kinase activity
C4K30_RS22085	COG1054	Belongs to the UPF0176 family
C4K30_RS22090	COG0271	Belongs to the BolA IbaG family
C4K30_RS22100	COG0114	fumarate hydratase activity
C4K30_RS22105	COG0697	spore germination
C4K30_RS22110	COG0183	Belongs to the thiolase family
C4K30_RS22115	COG2326	polyphosphate kinase activity
C4K30_RS22120	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4K30_RS22120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS22125	COG0367	asparagine synthase
C4K30_RS22130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K30_RS22130	COG0189	ligase activity
C4K30_RS22135	COG1363	Peptidase, m42
C4K30_RS22140	COG3089	Belongs to the UPF0270 family
C4K30_RS22145	COG1742	UPF0060 membrane protein
C4K30_RS22160	COG1368	sulfuric ester hydrolase activity
C4K30_RS22180	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS22195	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C4K30_RS22200	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4K30_RS22205	COG0235	Class ii aldolase
C4K30_RS22215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4K30_RS22220	COG1073	alpha beta
C4K30_RS22245	COG2840	Smr protein MutS2
C4K30_RS22250	COG0302	gtp cyclohydrolase
C4K30_RS22260	COG0625	glutathione transferase activity
C4K30_RS22265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K30_RS22275	COG2252	PERMEase
C4K30_RS22305	COG4266	Belongs to the allantoicase family
C4K30_RS22310	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4K30_RS22320	COG2233	PERMEase
C4K30_RS22350	COG1560	Kdo2-lipid A biosynthetic process
C4K30_RS22355	COG0850	regulation of cytokinetic process
C4K30_RS22360	COG2894	cell division
C4K30_RS22365	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4K30_RS22370	COG0564	pseudouridine synthase activity
C4K30_RS22380	COG1362	aminopeptidase activity
C4K30_RS22390	COG0668	transmembrane transport
C4K30_RS22395	COG1473	amidohydrolase
C4K30_RS22425	COG3842	ATPase activity
C4K30_RS22435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4K30_RS22435	COG3321	synthase
C4K30_RS22435	COG4221	oxidoreductase activity
C4K30_RS22435	COG0604	alcohol dehydrogenase
C4K30_RS22445	COG2200	EAL domain
C4K30_RS22470	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K30_RS22475	COG2010	Cytochrome c
C4K30_RS22505	COG2974	May be involved in recombination
C4K30_RS22510	COG0385	Bile acid
C4K30_RS22515	COG2076	Multidrug Resistance protein
C4K30_RS22520	COG0477	Major facilitator Superfamily
C4K30_RS22545	COG2202	Pas domain
C4K30_RS22545	COG2205	protein histidine kinase activity
C4K30_RS22595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4K30_RS22600	COG0406	alpha-ribazole phosphatase activity
C4K30_RS22605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4K30_RS22615	COG1492	cobalamin metabolic process
C4K30_RS22630	COG0778	Nitroreductase
C4K30_RS22635	COG1797	cobyrinic acid a,c-diamide synthase activity
C4K30_RS22660	COG0791	NLP P60 protein
C4K30_RS22665	COG0791	NLP P60 protein
C4K30_RS22670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4K30_RS22675	COG0628	permease
C4K30_RS22685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4K30_RS22690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4K30_RS22705	COG3122	Protein conserved in bacteria
C4K30_RS22710	COG3956	TIGRFAM MazG family protein
C4K30_RS22715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K30_RS22720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K30_RS22740	COG0784	Response regulator, receiver
C4K30_RS22740	COG5002	protein histidine kinase activity
C4K30_RS22740	COG2205	protein histidine kinase activity
C4K30_RS22745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K30_RS22765	COG1393	Belongs to the ArsC family
C4K30_RS22785	COG0037	tRNA processing
C4K30_RS22795	COG3091	SprT-like family
C4K30_RS22800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K30_RS22840	COG2205	protein histidine kinase activity
C4K30_RS22845	COG0745	RESPONSE REGULATOR receiver
C4K30_RS22855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K30_RS22855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K30_RS22860	COG1749	Flagellar hook protein flgE
C4K30_RS22870	COG1558	bacterial-type flagellum-dependent cell motility
C4K30_RS22875	COG1815	bacterial-type flagellum-dependent cell motility
C4K30_RS22880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4K30_RS22885	COG0784	Response regulator, receiver
C4K30_RS22885	COG0835	chemotaxis
C4K30_RS22905	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4K30_RS22910	COG0477	Major facilitator Superfamily
C4K30_RS22920	COG2205	protein histidine kinase activity
C4K30_RS22950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K30_RS22970	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4K30_RS22980	COG2239	Acts as a magnesium transporter
C4K30_RS23000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4K30_RS23005	COG0527	aspartate kinase activity
C4K30_RS23010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4K30_RS23015	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4K30_RS23020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K30_RS23025	COG2988	succinylglutamate desuccinylase activity
C4K30_RS23035	COG3724	N-succinylarginine dihydrolase activity
C4K30_RS23040	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS23055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K30_RS23085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS23090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K30_RS23100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4K30_RS23135	COG0563	adenylate kinase activity
C4K30_RS23150	COG3706	GGDEF domain
C4K30_RS23170	COG0504	CTP synthase activity
C4K30_RS23175	COG2329	Antibiotic biosynthesis monooxygenase
C4K30_RS23185	COG0584	glycerophosphoryl diester phosphodiesterase
C4K30_RS23215	COG0306	phosphate transporter
C4K30_RS23225	COG1984	allophanate hydrolase subunit 2
C4K30_RS23235	COG0439	Biotin carboxylase
C4K30_RS23245	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4K30_RS23260	COG3008	intermembrane lipid transfer
C4K30_RS23265	COG2995	paraquat-inducible protein a
C4K30_RS23270	COG2995	paraquat-inducible protein a
C4K30_RS23285	COG0583	DNA-binding transcription factor activity
C4K30_RS23290	COG4941	Belongs to the sigma-70 factor family
C4K30_RS23300	COG3795	YCII-related domain
C4K30_RS23345	COG0436	Aminotransferase
C4K30_RS23355	COG3265	gluconokinase activity
C4K30_RS23360	COG1609	Transcriptional regulator
C4K30_RS23375	COG0583	DNA-binding transcription factor activity
C4K30_RS23390	COG2271	Major facilitator Superfamily
C4K30_RS23400	COG0583	DNA-binding transcription factor activity
C4K30_RS23410	COG2986	histidine ammonia-lyase
C4K30_RS23420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS23435	COG3712	iron ion homeostasis
C4K30_RS23440	COG1595	DNA-templated transcription, initiation
C4K30_RS23465	COG0242	peptide deformylase activity
C4K30_RS23470	COG1295	ribonuclease BN
C4K30_RS23485	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS23490	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS23495	COG2267	carboxylic ester hydrolase activity
C4K30_RS23500	COG2030	dehydratase
C4K30_RS23525	COG3530	Putative quorum-sensing-regulated virulence factor
C4K30_RS23530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4K30_RS23535	COG0800	Aldolase
C4K30_RS23550	COG1737	Transcriptional regulator
C4K30_RS23555	COG0676	glucose-6-phosphate 1-epimerase activity
C4K30_RS23565	COG3842	ATPase activity
C4K30_RS23570	COG0395	ABC-type sugar transport system, permease component
C4K30_RS23575	COG1175	transmembrane transport
C4K30_RS23580	COG1653	transport
C4K30_RS23615	COG1803	Methylglyoxal synthase
C4K30_RS23625	COG3712	iron ion homeostasis
C4K30_RS23630	COG4771	TonB-dependent receptor
C4K30_RS23640	COG2832	Protein of unknown function (DUF454)
C4K30_RS23645	COG0840	transmembrane signaling receptor activity
C4K30_RS23650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4K30_RS23675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K30_RS23695	COG0509	glycine decarboxylation via glycine cleavage system
C4K30_RS23700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K30_RS23700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K30_RS23705	COG1760	l-serine dehydratase
C4K30_RS23710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K30_RS23715	COG1278	Cold shock
C4K30_RS23725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4K30_RS23730	COG4964	Belongs to the GSP D family
C4K30_RS23810	COG2894	cell division
C4K30_RS23830	COG0305	Participates in initiation and elongation during chromosome replication
C4K30_RS23845	COG3081	Nucleoid-associated protein
C4K30_RS23905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4K30_RS23910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4K30_RS24020	COG2197	response regulator
C4K30_RS24030	COG2197	response regulator
C4K30_RS24050	COG2205	protein histidine kinase activity
C4K30_RS24050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS24055	COG2885	chlorophyll binding
C4K30_RS24075	COG0668	transmembrane transport
C4K30_RS24110	COG4669	(LipO)protein
C4K30_RS24185	COG1157	protein secretion by the type III secretion system
C4K30_RS24210	COG4794	Type iii secretion
C4K30_RS24215	COG1684	flagellar biosynthetic protein fliR
C4K30_RS24220	COG4792	protein secretion
C4K30_RS24225	COG0791	NLP P60 protein
C4K30_RS24385	COG3385	transposase activity
C4K30_RS24395	COG3609	addiction module antidote protein, CC2985 family
C4K30_RS24410	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K30_RS24420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K30_RS24425	COG0602	queuosine metabolic process
C4K30_RS24430	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4K30_RS24435	COG2885	chlorophyll binding
C4K30_RS24440	COG0823	Involved in the tonB-independent uptake of proteins
C4K30_RS24460	COG0824	Thioesterase
C4K30_RS24465	COG2255	four-way junction helicase activity
C4K30_RS24470	COG0632	four-way junction helicase activity
C4K30_RS24475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4K30_RS24480	COG0217	transcriptional regulatory protein
C4K30_RS24485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4K30_RS24495	COG0783	Belongs to the Dps family
C4K30_RS24505	COG2900	Belongs to the SlyX family
C4K30_RS24525	COG0668	transmembrane transport
C4K30_RS24530	COG1666	GTP binding
C4K30_RS24540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS24540	COG4191	Histidine kinase
C4K30_RS24545	COG2096	Adenosyltransferase
C4K30_RS24560	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4K30_RS24565	COG0653	protein targeting
C4K30_RS24575	COG0433	COG0433 Predicted ATPase
C4K30_RS24585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K30_RS24585	COG0438	transferase activity, transferring glycosyl groups
C4K30_RS24610	COG2925	Exonuclease
C4K30_RS24635	COG0714	Associated with various cellular activities
C4K30_RS24655	COG0469	pyruvate kinase activity
C4K30_RS24660	COG1024	Enoyl-CoA hydratase
C4K30_RS24670	COG3706	GGDEF domain
C4K30_RS24685	COG4191	Histidine kinase
C4K30_RS24695	COG0477	Major facilitator Superfamily
C4K30_RS24725	COG2207	Transcriptional regulator
C4K30_RS24730	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS24740	COG0583	DNA-binding transcription factor activity
C4K30_RS24745	COG2910	NAD(P)H-binding
C4K30_RS24755	COG0583	DNA-binding transcription factor activity
C4K30_RS24785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4K30_RS24790	COG0583	DNA-binding transcription factor activity
C4K30_RS24805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4K30_RS24835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS24840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS24850	COG3642	lipopolysaccharide core region biosynthetic process
C4K30_RS24860	COG0642	Histidine kinase
C4K30_RS24875	COG0459	protein refolding
C4K30_RS24880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4K30_RS24890	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4K30_RS24900	COG1028	Short-chain dehydrogenase reductase Sdr
C4K30_RS24905	COG0489	protein tyrosine kinase activity
C4K30_RS24910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K30_RS24910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4K30_RS24915	COG4657	Part of a membrane complex involved in electron transport
C4K30_RS24920	COG2878	Part of a membrane complex involved in electron transport
C4K30_RS24925	COG4658	electron transport chain
C4K30_RS24930	COG4659	FMN binding
C4K30_RS24935	COG4660	Part of a membrane complex involved in electron transport
C4K30_RS24940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4K30_RS24950	COG2197	response regulator
C4K30_RS24955	COG0137	argininosuccinate synthase activity
C4K30_RS24965	COG0418	dihydroorotase activity
C4K30_RS24970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K30_RS24975	COG0450	alkyl hydroperoxide reductase
C4K30_RS24990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4K30_RS24995	COG3383	formate dehydrogenase (NAD+) activity
C4K30_RS25005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4K30_RS25010	COG3842	ATPase activity
C4K30_RS25015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4K30_RS25025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4K30_RS25040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS25045	COG0765	amino acid transport
C4K30_RS25050	COG0765	amino acid transport
C4K30_RS25055	COG1126	abc transporter atp-binding protein
C4K30_RS25085	COG2076	Multidrug Resistance protein
C4K30_RS25105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K30_RS25120	COG4191	Histidine kinase
C4K30_RS25140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K30_RS25145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4K30_RS25150	COG0583	DNA-binding transcription factor activity
C4K30_RS25160	COG1280	lysine exporter protein (LysE YggA)
C4K30_RS25170	COG0254	rRNA binding
C4K30_RS25175	COG2197	response regulator
C4K30_RS25180	COG0069	glutamate synthase activity
C4K30_RS25205	COG2246	polysaccharide biosynthetic process
C4K30_RS25220	COG1113	amino acid transport
C4K30_RS25230	COG1695	Transcriptional regulator
C4K30_RS25235	COG2375	cellular response to nickel ion
C4K30_RS25245	COG4628	conserved protein (DUF2132)
C4K30_RS25250	COG4206	TonB-dependent receptor
C4K30_RS25285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4K30_RS25300	COG2226	methyltransferase
C4K30_RS25305	COG0500	methyltransferase
C4K30_RS25310	COG0590	tRNA wobble adenosine to inosine editing
C4K30_RS25325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4K30_RS25325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4K30_RS25335	COG0366	Alpha amylase catalytic
C4K30_RS25340	COG1263	PTS System
C4K30_RS25340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4K30_RS25345	COG2188	Transcriptional regulator
C4K30_RS25360	COG0519	Catalyzes the synthesis of GMP from XMP
C4K30_RS25360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4K30_RS25385	COG1570	exodeoxyribonuclease VII activity
C4K30_RS25390	COG0739	heme binding
C4K30_RS25395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4K30_RS25405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K30_RS25410	COG0436	Aminotransferase
C4K30_RS25415	COG1160	GTP binding
C4K30_RS25430	COG0124	histidyl-tRNA synthetase
C4K30_RS25435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4K30_RS25440	COG1426	Protein conserved in bacteria
C4K30_RS25450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4K30_RS25455	COG0105	UTP biosynthetic process
C4K30_RS25465	COG0633	Ferredoxin
C4K30_RS25470	COG0443	Heat shock 70 kDa protein
C4K30_RS25475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K30_RS25490	COG1104	cysteine desulfurase activity
C4K30_RS25500	COG1045	serine acetyltransferase
C4K30_RS25515	COG3134	Outer membrane lipoprotein
C4K30_RS25530	COG1862	Preprotein translocase
C4K30_RS25535	COG0343	queuine tRNA-ribosyltransferase activity
C4K30_RS25540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4K30_RS25585	COG2853	Lipoprotein
C4K30_RS25630	COG0586	Pfam SNARE associated Golgi protein
C4K30_RS25635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4K30_RS25685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K30_RS25700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K30_RS25700	COG5322	oxidoreductase activity
C4K30_RS25705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4K30_RS25710	COG2771	luxR family
C4K30_RS25735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K30_RS25750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4K30_RS25755	COG0109	protoheme IX farnesyltransferase activity
C4K30_RS25765	COG1845	cytochrome c oxidase, subunit III
C4K30_RS25770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4K30_RS25775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4K30_RS25785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K30_RS25795	COG1017	nitric oxide dioxygenase activity
C4K30_RS25795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K30_RS25800	COG3604	Transcriptional regulator
C4K30_RS25805	COG0835	chemotaxis
C4K30_RS25805	COG0784	Response regulator, receiver
C4K30_RS25835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4K30_RS25845	COG5002	protein histidine kinase activity
C4K30_RS25860	COG5001	Diguanylate cyclase
C4K30_RS25860	COG4251	negative regulation of phosphorylation
C4K30_RS25860	COG3706	GGDEF domain
C4K30_RS25860	COG2203	Gaf domain
C4K30_RS25865	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4K30_RS25870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4K30_RS25885	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K30_RS25890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K30_RS25895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4K30_RS25900	COG0772	Belongs to the SEDS family
C4K30_RS25905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4K30_RS25910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4K30_RS25915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4K30_RS25920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4K30_RS25935	COG0275	rRNA processing
C4K30_RS25940	COG2001	Belongs to the MraZ family
C4K30_RS25955	COG3107	peptidoglycan biosynthetic process
C4K30_RS25960	COG0792	nuclease activity
C4K30_RS25965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4K30_RS25970	COG2823	Periplasmic or secreted lipoprotein
C4K30_RS25975	COG2969	positive regulation of protein catabolic process
C4K30_RS25980	COG0625	glutathione transferase activity
C4K30_RS25985	COG2857	Cytochrome c1
C4K30_RS25990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4K30_RS25995	COG0723	plastoquinol--plastocyanin reductase activity
C4K30_RS26000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4K30_RS26005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4K30_RS26010	COG0667	Aldo Keto reductase
C4K30_RS26015	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS26025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4K30_RS26030	COG0180	Tryptophanyl-tRNA synthetase
C4K30_RS26050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4K30_RS26055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4K30_RS26075	COG0642	Histidine kinase
C4K30_RS26080	COG2909	trisaccharide binding
C4K30_RS26095	COG0318	PFAM AMP-dependent synthetase and ligase
C4K30_RS26105	COG1280	lysine exporter protein (LysE YggA)
C4K30_RS26110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4K30_RS26115	COG2813	Specifically methylates the guanine in position
C4K30_RS26120	COG2119	membrane
C4K30_RS26125	COG0501	Belongs to the peptidase M48B family
C4K30_RS26130	COG0840	transmembrane signaling receptor activity
C4K30_RS26135	COG2135	peptidase activity
C4K30_RS26195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4K30_RS26200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4K30_RS26210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4K30_RS26215	COG1090	epimerase
C4K30_RS26220	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4K30_RS26240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4K30_RS26245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4K30_RS26255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4K30_RS26260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4K30_RS26270	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4K30_RS26275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4K30_RS26285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4K30_RS26290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4K30_RS26295	COG0193	aminoacyl-tRNA hydrolase activity
C4K30_RS26305	COG2197	response regulator
C4K30_RS26310	COG2205	protein histidine kinase activity
C4K30_RS26310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS26315	COG3397	chitin binding
C4K30_RS26380	COG2258	MOSC domain
C4K30_RS26405	COG2223	nitrite transmembrane transporter activity
C4K30_RS26460	COG0367	asparagine synthase
C4K30_RS26465	COG0405	Gamma-glutamyltransferase
C4K30_RS26480	COG4680	protein conserved in bacteria
C4K30_RS26500	COG0789	Transcriptional regulator
C4K30_RS26515	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4K30_RS26545	COG0662	Cupin 2, conserved barrel domain protein
C4K30_RS26555	COG0583	DNA-binding transcription factor activity
C4K30_RS26560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4K30_RS26570	COG0583	DNA-binding transcription factor activity
C4K30_RS26630	COG0477	Major facilitator Superfamily
C4K30_RS26635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K30_RS26650	COG2031	fatty acid transporter
C4K30_RS26665	COG0288	reversible hydration of carbon dioxide
C4K30_RS26675	COG0456	acetyltransferase
C4K30_RS26700	COG3008	intermembrane lipid transfer
C4K30_RS26705	COG2995	paraquat-inducible protein a
C4K30_RS26710	COG2995	paraquat-inducible protein a
C4K30_RS26745	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4K30_RS26750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4K30_RS26755	COG1183	phosphatidylcholine synthase activity
C4K30_RS26760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4K30_RS26770	COG0028	Belongs to the TPP enzyme family
C4K30_RS26790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K30_RS26820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4K30_RS26825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4K30_RS26830	COG4558	Periplasmic binding protein
C4K30_RS26840	COG1489	DNA binding
C4K30_RS26845	COG0436	Aminotransferase
C4K30_RS26855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4K30_RS26865	COG4191	Histidine kinase
C4K30_RS26890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4K30_RS26895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4K30_RS26905	COG0166	Belongs to the GPI family
C4K30_RS26910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4K30_RS26925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K30_RS26935	COG2823	Periplasmic or secreted lipoprotein
C4K30_RS26950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4K30_RS26955	COG0237	dephospho-CoA kinase activity
C4K30_RS26960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4K30_RS26980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4K30_RS27035	COG0728	peptidoglycan biosynthetic process
C4K30_RS27050	COG1252	NADH dehydrogenase
C4K30_RS27060	COG3121	Chaperone
C4K30_RS27065	COG3188	usher protein
C4K30_RS27090	COG0542	response to heat
C4K30_RS27120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS27160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4K30_RS27165	COG1047	Peptidyl-prolyl cis-trans
C4K30_RS27170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4K30_RS27175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4K30_RS27180	COG0196	riboflavin kinase activity
C4K30_RS27195	COG0268	Binds directly to 16S ribosomal RNA
C4K30_RS27200	COG3045	CreA protein
C4K30_RS27205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4K30_RS27210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4K30_RS27215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4K30_RS27220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4K30_RS27225	COG0142	geranyltranstransferase activity
C4K30_RS27230	COG2824	Alkylphosphonate utilization operon protein PhnA
C4K30_RS27235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K30_RS27240	COG0545	Peptidyl-prolyl cis-trans isomerase
C4K30_RS27250	COG2862	Uncharacterized protein family, UPF0114
C4K30_RS27265	COG1067	ATP-dependent peptidase activity
C4K30_RS27285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K30_RS27295	COG0488	(ABC) transporter
C4K30_RS27305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K30_RS27320	COG2186	Transcriptional regulator
C4K30_RS27330	COG0523	cobalamin synthesis protein
C4K30_RS27335	COG2879	small protein
C4K30_RS27340	COG1966	Carbon starvation protein
C4K30_RS27375	COG1970	mechanosensitive ion channel activity
C4K30_RS27385	COG2813	Specifically methylates the guanine in position
C4K30_RS27395	COG1294	oxidase, subunit
C4K30_RS27400	COG1271	oxidase subunit
C4K30_RS27425	COG2252	PERMEase
C4K30_RS27430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4K30_RS27455	COG1629	transport
C4K30_RS27470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4K30_RS27475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4K30_RS27480	COG3135	benzoate transporter
C4K30_RS27490	COG1309	transcriptional regulator
C4K30_RS27495	COG1082	Xylose isomerase domain protein TIM barrel
C4K30_RS27495	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4K30_RS27515	COG0673	inositol 2-dehydrogenase activity
C4K30_RS27525	COG1053	succinate dehydrogenase
C4K30_RS27530	COG3485	protocatechuate 3,4-dioxygenase
C4K30_RS27535	COG3485	protocatechuate 3,4-dioxygenase
C4K30_RS27540	COG0583	DNA-binding transcription factor activity
C4K30_RS27545	COG2321	neutral zinc metallopeptidase
C4K30_RS27560	COG1946	Acyl-CoA thioesterase
C4K30_RS27570	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4K30_RS27580	COG0513	Belongs to the DEAD box helicase family
C4K30_RS27590	COG0697	spore germination
C4K30_RS27595	COG1522	sequence-specific DNA binding
C4K30_RS27600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4K30_RS27600	COG1199	ATP-dependent helicase activity
C4K30_RS27610	COG3416	Protein conserved in bacteria
C4K30_RS27660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K30_RS27695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4K30_RS27760	COG1643	Atp-dependent helicase
C4K30_RS27780	COG1522	sequence-specific DNA binding
C4K30_RS27795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4K30_RS27800	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS27805	COG2205	protein histidine kinase activity
C4K30_RS27805	COG2198	Histidine kinase
C4K30_RS27805	COG0784	Response regulator, receiver
C4K30_RS27810	COG0351	phosphomethylpyrimidine kinase
C4K30_RS27815	COG0352	thiamine-phosphate diphosphorylase activity
C4K30_RS27820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4K30_RS27835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4K30_RS27840	COG1702	phosphate starvation-inducible protein PhoH
C4K30_RS27845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4K30_RS27850	COG4535	Mg2 and Co2 transporter CorC
C4K30_RS27855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4K30_RS27870	COG0495	leucyl-tRNA aminoacylation
C4K30_RS27890	COG2951	lytic endotransglycosylase activity
C4K30_RS27895	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4K30_RS27900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4K30_RS27905	COG0321	lipoyl(octanoyl) transferase activity
C4K30_RS27910	COG2921	Belongs to the UPF0250 family
C4K30_RS27915	COG1686	Belongs to the peptidase S11 family
C4K30_RS27925	COG2951	lytic endotransglycosylase activity
C4K30_RS27930	COG0772	Belongs to the SEDS family
C4K30_RS27935	COG0768	penicillin binding
C4K30_RS27940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4K30_RS27950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4K30_RS27955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4K30_RS27960	COG2094	Belongs to the DNA glycosylase MPG family
C4K30_RS27965	COG0586	Pfam SNARE associated Golgi protein
C4K30_RS27975	COG1346	cytolysis
C4K30_RS27995	COG0702	epimerase
C4K30_RS28010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4K30_RS28015	COG3284	Transcriptional regulator
C4K30_RS28025	COG0531	amino acid
C4K30_RS28030	COG4303	Ethanolamine ammonia lyase large subunit
C4K30_RS28035	COG4302	ethanolamine ammonia-lyase activity
C4K30_RS28040	COG0456	acetyltransferase
C4K30_RS28045	COG0586	Pfam SNARE associated Golgi protein
C4K30_RS28050	COG3228	Belongs to the MtfA family
C4K30_RS28055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4K30_RS28060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K30_RS28070	COG0583	DNA-binding transcription factor activity
C4K30_RS28090	COG1335	isochorismatase
C4K30_RS28110	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4K30_RS28115	COG3657	addiction module killer protein
C4K30_RS28125	COG0604	alcohol dehydrogenase
C4K30_RS28125	COG3321	synthase
C4K30_RS28130	COG0640	Transcriptional regulator
C4K30_RS28140	COG1722	exodeoxyribonuclease VII activity
C4K30_RS28145	COG0142	geranyltranstransferase activity
C4K30_RS28150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4K30_RS28155	COG4206	TonB-dependent receptor
C4K30_RS28170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4K30_RS28180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4K30_RS28190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4K30_RS28195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4K30_RS28210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K30_RS28210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4K30_RS28215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4K30_RS28225	COG2264	protein methyltransferase activity
C4K30_RS28230	COG3118	belongs to the thioredoxin family
C4K30_RS28260	COG3047	cAMP biosynthetic process
C4K30_RS28280	COG2814	Major facilitator Superfamily
C4K30_RS28290	COG3568	Endonuclease Exonuclease Phosphatase
C4K30_RS28295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K30_RS28300	COG0392	lysyltransferase activity
C4K30_RS28310	COG1335	isochorismatase
C4K30_RS28315	COG0629	single-stranded DNA binding
C4K30_RS28320	COG2814	Major facilitator Superfamily
C4K30_RS28325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4K30_RS28330	COG2193	ferroxidase activity
C4K30_RS28340	COG0203	ribosomal protein L17
C4K30_RS28345	COG0202	RNA polymerase activity
C4K30_RS28350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4K30_RS28355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4K30_RS28360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4K30_RS28365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4K30_RS28375	COG0200	Binds to the 23S rRNA
C4K30_RS28380	COG1841	ribosomal large subunit assembly
C4K30_RS28385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4K30_RS28390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4K30_RS28395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4K30_RS28400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4K30_RS28405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4K30_RS28410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4K30_RS28415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4K30_RS28420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4K30_RS28425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4K30_RS28430	COG0255	Belongs to the universal ribosomal protein uL29 family
C4K30_RS28435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4K30_RS28440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4K30_RS28445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4K30_RS28450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4K30_RS28455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4K30_RS28460	COG0089	rRNA binding
C4K30_RS28465	COG0088	Forms part of the polypeptide exit tunnel
C4K30_RS28470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4K30_RS28475	COG0051	transcription antitermination factor activity, RNA binding
C4K30_RS28480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K30_RS28485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4K30_RS28490	COG0049	tRNA binding
C4K30_RS28495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4K30_RS28500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4K30_RS28505	COG0085	RNA polymerase activity
C4K30_RS28510	COG0222	ribosome binding
C4K30_RS28515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4K30_RS28520	COG0081	regulation of translation
C4K30_RS28525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4K30_RS28545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4K30_RS28570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4K30_RS28610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4K30_RS28615	COG0739	heme binding
C4K30_RS28620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4K30_RS28625	COG0316	Belongs to the HesB IscA family
C4K30_RS28630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4K30_RS28635	COG1981	membrane
C4K30_RS28650	COG4221	oxidoreductase activity
C4K30_RS28655	COG0537	adenosine 5'-monophosphoramidase activity
C4K30_RS28660	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4K30_RS28665	COG1765	OsmC-like protein
C4K30_RS28680	COG0134	indole-3-glycerol-phosphate synthase activity
C4K30_RS28685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4K30_RS28690	COG0512	Glutamine amidotransferase of anthranilate synthase
C4K30_RS28700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4K30_RS28705	COG0546	phosphoglycolate phosphatase activity
C4K30_RS28710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4K30_RS28715	COG1454	alcohol dehydrogenase
C4K30_RS28725	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K30_RS28735	COG3842	ATPase activity
C4K30_RS28740	COG2197	response regulator
C4K30_RS28745	COG4585	Histidine kinase
C4K30_RS28755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4K30_RS28760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4K30_RS28765	COG3178	'Phosphotransferase
C4K30_RS28770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4K30_RS28775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4K30_RS28780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4K30_RS28785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4K30_RS28790	COG2967	ApaG domain
C4K30_RS28795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4K30_RS28800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4K30_RS28805	COG2766	serine protein kinase
C4K30_RS28810	COG2718	Belongs to the UPF0229 family
C4K30_RS28815	COG2719	SpoVR family
C4K30_RS28820	COG0617	tRNA 3'-terminal CCA addition
C4K30_RS28830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4K30_RS28835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4K30_RS28840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4K30_RS28845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4K30_RS28850	COG0358	DNA primase activity
C4K30_RS28855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4K30_RS28890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4K30_RS28895	COG1025	Belongs to the peptidase M16 family
C4K30_RS28905	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4K30_RS28910	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4K30_RS28920	COG0535	radical SAM domain protein
C4K30_RS28945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4K30_RS28950	COG2258	MOSC domain
C4K30_RS28955	COG0583	DNA-binding transcription factor activity
C4K30_RS28960	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS28965	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS28970	COG3706	GGDEF domain
C4K30_RS28975	COG1960	acyl-CoA dehydrogenase activity
C4K30_RS28995	COG1073	alpha beta
C4K30_RS28995	COG2226	methyltransferase
C4K30_RS29000	COG0156	8-amino-7-oxononanoate synthase activity
C4K30_RS29005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4K30_RS29015	COG3585	molybdate ion transport
C4K30_RS29015	COG2005	Transcriptional regulator
C4K30_RS29025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4K30_RS29040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4K30_RS29060	COG1595	DNA-templated transcription, initiation
C4K30_RS29065	COG3712	iron ion homeostasis
C4K30_RS29070	COG4774	siderophore transport
C4K30_RS29090	COG0625	glutathione transferase activity
C4K30_RS29095	COG4452	Inner membrane protein CreD
C4K30_RS29100	COG2205	protein histidine kinase activity
C4K30_RS29105	COG0745	RESPONSE REGULATOR receiver
C4K30_RS29110	COG4067	protein conserved in archaea
C4K30_RS29110	COG0189	ligase activity
C4K30_RS29115	COG0204	Acyl-transferase
C4K30_RS29125	COG1063	alcohol dehydrogenase
C4K30_RS29155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4K30_RS29175	COG1017	nitric oxide dioxygenase activity
C4K30_RS29175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4K30_RS29185	COG4638	Rieske (2fe-2S)
C4K30_RS29195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4K30_RS29200	COG2181	nitrate reductase activity
C4K30_RS29200	COG0247	lactate metabolic process
C4K30_RS29205	COG1902	pentaerythritol trinitrate reductase activity
C4K30_RS29205	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4K30_RS29255	COG3246	L-lysine catabolic process to acetate
C4K30_RS29260	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4K30_RS29290	COG1760	l-serine dehydratase
C4K30_RS29300	COG4176	ABC-type proline glycine betaine transport system permease component
C4K30_RS29305	COG4175	Glycine betaine
C4K30_RS29310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4K30_RS29315	COG1309	transcriptional regulator
C4K30_RS29320	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS29325	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K30_RS29340	COG0312	modulator of DNA gyrase
C4K30_RS29345	COG0477	Major facilitator Superfamily
C4K30_RS29350	COG0513	Belongs to the DEAD box helicase family
C4K30_RS29355	COG2081	HI0933 family
C4K30_RS29360	COG1289	transmembrane transporter activity
C4K30_RS29370	COG2153	protein acetylation
C4K30_RS29380	COG1451	nucleotide metabolic process
C4K30_RS29410	COG0126	phosphoglycerate kinase activity
C4K30_RS29415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4K30_RS29425	COG0640	Transcriptional regulator
C4K30_RS29430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4K30_RS29435	COG1422	Protein of unknown function (DUF1090)
C4K30_RS29460	COG2814	Major facilitator Superfamily
C4K30_RS29475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4K30_RS29480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4K30_RS29495	COG0513	Belongs to the DEAD box helicase family
C4K30_RS29500	COG2353	YceI-like domain
C4K30_RS29505	COG3038	cytochrome b561
C4K30_RS29515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4K30_RS29540	COG1272	protein, Hemolysin III
C4K30_RS29560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4K30_RS29580	COG3052	prosthetic group binding
C4K30_RS29585	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4K30_RS29605	COG2198	Histidine kinase
C4K30_RS29605	COG0784	Response regulator, receiver
C4K30_RS29605	COG0643	Histidine kinase
C4K30_RS29630	COG0189	ligase activity
C4K30_RS29640	COG1678	Uncharacterized ACR, COG1678
C4K30_RS29645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4K30_RS29650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4K30_RS29655	COG0540	Belongs to the ATCase OTCase family
C4K30_RS29660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K30_RS29670	COG0791	NLP P60 protein
C4K30_RS29695	COG1872	DUF167
C4K30_RS29700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K30_RS29705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4K30_RS29705	COG2813	Specifically methylates the guanine in position
C4K30_RS29715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4K30_RS29720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4K30_RS29735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4K30_RS29740	COG2022	thiamine diphosphate biosynthetic process
C4K30_RS29750	COG2363	Small membrane protein
C4K30_RS29755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4K30_RS29765	COG2177	Part of the ABC transporter FtsEX involved in
C4K30_RS29770	COG2884	Cell division ATP-binding protein ftsE
C4K30_RS29775	COG0552	protein localization to endoplasmic reticulum
C4K30_RS29780	COG0612	Peptidase, M16
C4K30_RS29785	COG0612	Peptidase, M16
C4K30_RS29790	COG0742	ribosomal rna small subunit methyltransferase
C4K30_RS29825	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4K30_RS29830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4K30_RS29835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4K30_RS29840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4K30_RS29850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4K30_RS29860	COG0129	dihydroxy-acid dehydratase activity
C4K30_RS29870	COG1823	symporter activity
C4K30_RS29885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K30_RS29900	COG1840	ABC-type Fe3 transport system, periplasmic component
C4K30_RS29905	COG1178	ABC-type Fe3 transport system permease component
C4K30_RS29910	COG3842	ATPase activity
C4K30_RS29915	COG0583	DNA-binding transcription factor activity
C4K30_RS29925	COG0789	Transcriptional regulator
C4K30_RS29930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4K30_RS29935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4K30_RS29940	COG0730	response to heat
C4K30_RS29955	COG0494	nUDIX hydrolase
C4K30_RS29970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4K30_RS29975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4K30_RS29980	COG2234	aminopeptidase activity
C4K30_RS29985	COG3204	pilus organization
C4K30_RS29990	COG3204	pilus organization
C4K30_RS29995	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4K30_RS30000	COG0277	FAD linked oxidase domain protein
C4K30_RS30005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4K30_RS30015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS30020	COG1683	Conserved Protein
C4K30_RS30050	COG1177	transmembrane transport
C4K30_RS30055	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4K30_RS30060	COG3842	ATPase activity
C4K30_RS30080	COG0174	glutamine synthetase
C4K30_RS30085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K30_RS30090	COG0174	glutamine synthetase
C4K30_RS30105	COG1116	anion transmembrane transporter activity
C4K30_RS30110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4K30_RS30115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4K30_RS30120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4K30_RS30125	COG0431	NADPH-dependent FMN reductase
C4K30_RS30130	COG0450	alkyl hydroperoxide reductase
C4K30_RS30140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4K30_RS30140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K30_RS30145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4K30_RS30155	COG1522	sequence-specific DNA binding
C4K30_RS30165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4K30_RS30180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K30_RS30180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4K30_RS30185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K30_RS30200	COG0509	glycine decarboxylation via glycine cleavage system
C4K30_RS30205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4K30_RS30210	COG1178	ABC-type Fe3 transport system permease component
C4K30_RS30220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K30_RS30225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K30_RS30230	COG0006	proline dipeptidase activity
C4K30_RS30235	COG3079	Belongs to the UPF0149 family
C4K30_RS30255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4K30_RS30265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4K30_RS30270	COG0842	Transport permease protein
C4K30_RS30270	COG1129	ABC transporter
C4K30_RS30275	COG0842	Transport permease protein
C4K30_RS30285	COG0604	alcohol dehydrogenase
C4K30_RS30290	COG2271	Major facilitator Superfamily
C4K30_RS30305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4K30_RS30320	COG2186	Transcriptional regulator
C4K30_RS30325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS30330	COG0765	amino acid transport
C4K30_RS30335	COG0765	amino acid transport
C4K30_RS30340	COG1126	abc transporter atp-binding protein
C4K30_RS30345	COG0248	Ppx GppA phosphatase
C4K30_RS30350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4K30_RS30360	COG0586	Pfam SNARE associated Golgi protein
C4K30_RS30370	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4K30_RS30375	COG1671	Belongs to the UPF0178 family
C4K30_RS30380	COG0672	)-iron permease
C4K30_RS30385	COG1280	lysine exporter protein (LysE YggA)
C4K30_RS30395	COG0488	(ABC) transporter
C4K30_RS30420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4K30_RS30440	COG0181	hydroxymethylbilane synthase activity
C4K30_RS30450	COG0165	Argininosuccinate lyase
C4K30_RS30455	COG0625	glutathione transferase activity
C4K30_RS30470	COG3072	Adenylate cyclase
C4K30_RS30475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4K30_RS30485	COG1965	Belongs to the frataxin family
C4K30_RS30495	COG0019	diaminopimelate decarboxylase activity
C4K30_RS30500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4K30_RS30510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4K30_RS30515	COG1011	Hydrolase
C4K30_RS30525	COG0432	Pfam Uncharacterised protein family UPF0047
C4K30_RS30530	COG0004	ammonium transporteR
C4K30_RS30535	COG0347	Belongs to the P(II) protein family
C4K30_RS30550	COG0529	Catalyzes the synthesis of activated sulfate
C4K30_RS30560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4K30_RS30565	COG0574	Belongs to the PEP-utilizing enzyme family
C4K30_RS30565	COG3848	Pyruvate phosphate dikinase
C4K30_RS30570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4K30_RS30575	COG1213	nucleotidyl transferase
C4K30_RS30580	COG0606	chelatase, subunit chli
C4K30_RS30610	COG0583	DNA-binding transcription factor activity
C4K30_RS30615	COG0534	Mate efflux family protein
C4K30_RS30630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4K30_RS30635	COG0427	acetyl-CoA hydrolase
C4K30_RS30650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4K30_RS30655	COG0251	oxidation-reduction process
C4K30_RS30660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS30675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4K30_RS30685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4K30_RS30690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K30_RS30700	COG1012	belongs to the aldehyde dehydrogenase family
C4K30_RS30710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4K30_RS30715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4K30_RS30720	COG0747	negative chemotaxis
C4K30_RS30725	COG2003	Belongs to the UPF0758 family
C4K30_RS30730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4K30_RS30735	COG0756	dUTP diphosphatase activity
C4K30_RS30740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4K30_RS30745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4K30_RS30750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4K30_RS30755	COG0708	Exodeoxyribonuclease III
C4K30_RS30765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4K30_RS30770	COG1561	YicC-like family, N-terminal region
C4K30_RS30775	COG0194	GDP metabolic process
C4K30_RS30780	COG1758	RNA polymerase activity
C4K30_RS30785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4K30_RS30810	COG0848	biopolymer transport protein
C4K30_RS30820	COG0583	DNA-binding transcription factor activity
C4K30_RS30825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4K30_RS30900	COG0515	serine threonine protein kinase
C4K30_RS30940	COG2204	response regulator
C4K30_RS31020	COG3161	chorismate lyase activity
C4K30_RS31025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4K30_RS31045	COG1253	flavin adenine dinucleotide binding
C4K30_RS31050	COG0739	heme binding
C4K30_RS31070	COG0704	Plays a role in the regulation of phosphate uptake
C4K30_RS31075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4K30_RS31080	COG0573	inorganic phosphate transmembrane transporter activity
C4K30_RS31095	COG0477	Major facilitator Superfamily
C4K30_RS31100	COG1607	acyl-coa hydrolase
C4K30_RS31130	COG0583	DNA-binding transcription factor activity
C4K30_RS31135	COG1027	Aspartate ammonia-lyase
C4K30_RS31150	COG1115	amino acid carrier protein
C4K30_RS31155	COG0252	asparaginase activity
C4K30_RS31180	COG2391	methyltransferase activity
C4K30_RS31210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4K30_RS31215	COG0765	amino acid transport
C4K30_RS31225	COG5016	pyruvate
C4K30_RS31225	COG0511	ligase activity, forming carbon-carbon bonds
C4K30_RS31230	COG0439	Biotin carboxylase
C4K30_RS31235	COG0583	DNA-binding transcription factor activity
C4K30_RS31255	COG0210	DNA helicase
C4K30_RS31275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4K30_RS31275	COG4651	solute:proton antiporter activity
C4K30_RS31280	COG1607	acyl-coa hydrolase
C4K30_RS31285	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4K30_RS31295	COG0523	cobalamin synthesis protein
C4K30_RS31320	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4K30_RS31325	COG1469	GTP cyclohydrolase I activity
C4K30_RS31330	COG1121	(ABC) transporter
C4K30_RS31340	COG0803	Belongs to the bacterial solute-binding protein 9 family
C4K30_RS31345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4K30_RS31355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4K30_RS31360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4K30_RS31370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4K30_RS31375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4K30_RS31380	COG2217	Heavy metal translocating P-type atpase
C4K30_RS31400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4K30_RS31405	COG2267	carboxylic ester hydrolase activity
C4K30_RS31410	COG2453	phosphatase
C4K30_RS31410	COG0671	phosphoesterase, PA-phosphatase related
C4K30_RS31425	COG4589	Belongs to the CDS family
C4K30_RS31430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4K30_RS31440	COG1280	lysine exporter protein (LysE YggA)
C4K30_RS31445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4K30_RS31450	COG2755	lipolytic protein G-D-S-L family
C4K30_RS31450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4K30_RS31485	COG0297	glycogen (starch) synthase activity
C4K30_RS31500	COG0625	glutathione transferase activity
C4K30_RS31505	COG0583	DNA-binding transcription factor activity
C4K30_RS31510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4K30_RS31525	COG0494	nUDIX hydrolase
C4K30_RS31530	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4K30_RS31545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4K30_RS31550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4K30_RS31555	COG0494	nUDIX hydrolase
C4K30_RS31630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4K30_RS31635	COG1349	DNA-binding transcription factor activity
C4K30_RS31640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4K30_RS31645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4K30_RS31650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4K30_RS31655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4K30_RS31660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4K30_RS31665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4K30_RS31670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4K30_RS31680	COG0356	it plays a direct role in the translocation of protons across the membrane
C4K30_RS31685	COG3312	ion transport
C4K30_RS31690	COG1475	DNA binding
C4K30_RS31695	COG1192	Involved in chromosome partitioning
C4K30_RS31700	COG0357	Ribosomal RNA small subunit methyltransferase G
C4K30_RS31705	COG0445	tRNA wobble uridine modification
C4K30_RS31710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4K30_RS31715	COG0706	membrane insertase activity
C4K30_RS31720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4K30_RS31725	COG0594	ribonuclease P activity
C4K30_RS31730	COG0230	Belongs to the bacterial ribosomal protein bL34 family