locus-tag	class	description
I6I45_RS00025	COG1677	Flagellar hook-basal body complex protein FliE
I6I45_RS00060	COG0745	RESPONSE REGULATOR receiver
I6I45_RS00120	COG1278	Cold shock
I6I45_RS00125	COG1278	Cold shock
I6I45_RS00160	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I45_RS00165	COG0784	Response regulator, receiver
I6I45_RS00165	COG0643	Histidine kinase
I6I45_RS00165	COG2198	Histidine kinase
I6I45_RS00170	COG2201	protein-glutamate methylesterase activity
I6I45_RS00175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I45_RS00180	COG1360	Flagellar Motor Protein
I6I45_RS00185	COG1192	Involved in chromosome partitioning
I6I45_RS00195	COG0835	chemotaxis
I6I45_RS00205	COG1597	lipid kinase activity
I6I45_RS00210	COG2197	response regulator
I6I45_RS00215	COG3851	Histidine kinase
I6I45_RS00230	COG3217	Mosc domain protein beta barrel domain protein
I6I45_RS00230	COG0633	Ferredoxin
I6I45_RS00235	COG3123	guanosine phosphorylase activity
I6I45_RS00250	COG1024	Enoyl-CoA hydratase
I6I45_RS00255	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS00260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I45_RS00275	COG1309	transcriptional regulator
I6I45_RS00310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I45_RS00345	COG1473	amidohydrolase
I6I45_RS00350	COG0668	transmembrane transport
I6I45_RS00360	COG1362	aminopeptidase activity
I6I45_RS00365	COG0564	pseudouridine synthase activity
I6I45_RS00370	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I45_RS00375	COG2894	cell division
I6I45_RS00380	COG0850	regulation of cytokinetic process
I6I45_RS00385	COG1560	Kdo2-lipid A biosynthetic process
I6I45_RS00405	COG2233	PERMEase
I6I45_RS00415	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6I45_RS00420	COG4266	Belongs to the allantoicase family
I6I45_RS00450	COG2252	PERMEase
I6I45_RS00455	COG0625	glutathione transferase activity
I6I45_RS00460	COG0583	DNA-binding transcription factor activity
I6I45_RS00465	COG2851	Citrate transporter
I6I45_RS00485	COG0302	gtp cyclohydrolase
I6I45_RS00490	COG2840	Smr protein MutS2
I6I45_RS00515	COG1073	alpha beta
I6I45_RS00520	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I45_RS00530	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I45_RS00535	COG2197	response regulator
I6I45_RS00545	COG0318	PFAM AMP-dependent synthetase and ligase
I6I45_RS00565	COG1368	sulfuric ester hydrolase activity
I6I45_RS00580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I45_RS00585	COG3089	Belongs to the UPF0270 family
I6I45_RS00595	COG0189	ligase activity
I6I45_RS00595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I45_RS00600	COG0367	asparagine synthase
I6I45_RS00605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS00605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I45_RS00610	COG2326	polyphosphate kinase activity
I6I45_RS00615	COG0183	Belongs to the thiolase family
I6I45_RS00620	COG0697	spore germination
I6I45_RS00625	COG0114	fumarate hydratase activity
I6I45_RS00635	COG0271	Belongs to the BolA IbaG family
I6I45_RS00640	COG1054	Belongs to the UPF0176 family
I6I45_RS00655	COG5001	Diguanylate cyclase
I6I45_RS00655	COG5002	protein histidine kinase activity
I6I45_RS00670	COG1304	FMN binding
I6I45_RS00675	COG0583	DNA-binding transcription factor activity
I6I45_RS00700	COG3135	benzoate transporter
I6I45_RS00720	COG0745	RESPONSE REGULATOR receiver
I6I45_RS00725	COG2205	protein histidine kinase activity
I6I45_RS00745	COG2391	methyltransferase activity
I6I45_RS00800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I45_RS00810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I45_RS00825	COG3469	chitinase activity
I6I45_RS00840	COG2186	Transcriptional regulator
I6I45_RS00845	COG2384	SAM-dependent methyltransferase
I6I45_RS00855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I45_RS00935	COG3545	Serine hydrolase
I6I45_RS00940	COG1309	transcriptional regulator
I6I45_RS01010	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6I45_RS01025	COG1120	ATPase activity
I6I45_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I45_RS01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I45_RS01040	COG1864	DNA RNA non-specific endonuclease
I6I45_RS01040	COG3591	Belongs to the peptidase S1B family
I6I45_RS01055	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS01060	COG0583	DNA-binding transcription factor activity
I6I45_RS01075	COG0556	nucleotide-excision repair
I6I45_RS01080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I45_RS01120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I45_RS01135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I45_RS01140	COG0066	3-isopropylmalate dehydratase activity
I6I45_RS01145	COG2226	methyltransferase
I6I45_RS01150	COG0473	3-isopropylmalate dehydrogenase activity
I6I45_RS01175	COG0135	phosphoribosylanthranilate isomerase activity
I6I45_RS01180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I45_RS01185	COG0285	dihydrofolate synthase activity
I6I45_RS01190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I45_RS01195	COG1286	toxin biosynthetic process
I6I45_RS01230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I45_RS01240	COG2010	Cytochrome c
I6I45_RS01245	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I45_RS01245	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I45_RS01250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS01280	COG0642	Histidine kinase
I6I45_RS01295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I45_RS01310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I45_RS01340	COG1129	ABC transporter
I6I45_RS01345	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I45_RS01350	COG1609	Transcriptional regulator
I6I45_RS01355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I45_RS01360	COG1869	D-ribose catabolic process
I6I45_RS01385	COG1278	Cold shock
I6I45_RS01395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I45_RS01400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I45_RS01405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I45_RS01410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I45_RS01415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I45_RS01420	COG0072	phenylalanine-tRNA ligase activity
I6I45_RS01425	COG0776	regulation of translation
I6I45_RS01445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I45_RS01455	COG1609	Transcriptional regulator
I6I45_RS01460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I45_RS01465	COG1459	type II secretion system
I6I45_RS01470	COG2165	general secretion pathway protein
I6I45_RS01480	COG2165	general secretion pathway protein
I6I45_RS01490	COG3156	type II secretion system protein K
I6I45_RS01495	COG3166	PFAM Fimbrial assembly family protein
I6I45_RS01510	COG1450	Type ii and iii secretion system protein
I6I45_RS01525	COG0667	Aldo Keto reductase
I6I45_RS01530	COG0625	glutathione transferase activity
I6I45_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS01585	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS01600	COG0531	amino acid
I6I45_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS01635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS01640	COG1846	Transcriptional regulator
I6I45_RS01650	COG3971	2-oxopent-4-enoate hydratase activity
I6I45_RS01655	COG2271	Major facilitator Superfamily
I6I45_RS01665	COG3384	dioxygenase
I6I45_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS01745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I45_RS01750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I45_RS01785	COG1879	ABC-type sugar transport system periplasmic component
I6I45_RS01795	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I45_RS01800	COG1063	alcohol dehydrogenase
I6I45_RS01805	COG1070	Carbohydrate kinase
I6I45_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS01815	COG1609	Transcriptional regulator
I6I45_RS01860	COG2186	Transcriptional regulator
I6I45_RS01870	COG1538	Outer membrane efflux protein
I6I45_RS01875	COG1136	(ABC) transporter
I6I45_RS01875	COG0577	efflux transmembrane transporter activity
I6I45_RS01880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS01920	COG4215	(ABC) transporter
I6I45_RS01930	COG2423	ornithine cyclodeaminase activity
I6I45_RS01950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I45_RS01955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I45_RS01965	COG0022	dehydrogenase e1 component
I6I45_RS01970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I45_RS01975	COG1522	sequence-specific DNA binding
I6I45_RS01985	COG0640	Transcriptional regulator
I6I45_RS02025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I45_RS02035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I45_RS02050	COG2372	response to copper ion
I6I45_RS02055	COG1309	transcriptional regulator
I6I45_RS02075	COG1953	Uracil, thiamine, allantoin
I6I45_RS02115	COG1686	Belongs to the peptidase S11 family
I6I45_RS02120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I45_RS02145	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I45_RS02150	COG0740	serine-type endopeptidase activity
I6I45_RS02155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I45_RS02160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I45_RS02165	COG0776	regulation of translation
I6I45_RS02170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I45_RS02175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I45_RS02185	COG0583	DNA-binding transcription factor activity
I6I45_RS02205	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS02205	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I45_RS02215	COG3038	cytochrome b561
I6I45_RS02220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I45_RS02225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I45_RS02230	COG0583	DNA-binding transcription factor activity
I6I45_RS02240	COG2271	Major facilitator Superfamily
I6I45_RS02245	COG0217	transcriptional regulatory protein
I6I45_RS02255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I45_RS02315	COG2866	Carboxypeptidase
I6I45_RS02340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I45_RS02345	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
I6I45_RS02360	COG0789	Transcriptional regulator
I6I45_RS02370	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS02380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I45_RS02385	COG0708	Exodeoxyribonuclease III
I6I45_RS02395	COG0729	surface antigen
I6I45_RS02400	COG2911	Protein conserved in bacteria
I6I45_RS02405	COG1846	Transcriptional regulator
I6I45_RS02415	COG1566	PFAM secretion protein HlyD family protein
I6I45_RS02420	COG2814	Major facilitator Superfamily
I6I45_RS02425	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I45_RS02435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I45_RS02440	COG0215	cysteine-tRNA ligase activity
I6I45_RS02455	COG1320	monovalent cation:proton antiporter activity
I6I45_RS02460	COG2212	antiporter activity
I6I45_RS02470	COG0651	ATP synthesis coupled electron transport
I6I45_RS02475	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I45_RS02480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I45_RS02480	COG2111	Na H antiporter
I6I45_RS02500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS02510	COG0577	efflux transmembrane transporter activity
I6I45_RS02510	COG1136	(ABC) transporter
I6I45_RS02515	COG0577	efflux transmembrane transporter activity
I6I45_RS02515	COG1136	(ABC) transporter
I6I45_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS02580	COG2944	sequence-specific DNA binding
I6I45_RS02585	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I45_RS02590	COG1007	ATP synthesis coupled electron transport
I6I45_RS02605	COG0713	ATP synthesis coupled electron transport
I6I45_RS02615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I45_RS02620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I45_RS02625	COG1034	ATP synthesis coupled electron transport
I6I45_RS02640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I45_RS02640	COG0649	NAD binding
I6I45_RS02645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I45_RS02650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I45_RS02655	COG2224	Isocitrate lyase
I6I45_RS02665	COG2153	protein acetylation
I6I45_RS02670	COG2850	peptidyl-arginine hydroxylation
I6I45_RS02680	COG2915	High frequency lysogenization protein hflD homolog
I6I45_RS02685	COG0482	sulfurtransferase activity
I6I45_RS02705	COG1278	Cold shock
I6I45_RS02710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I45_RS02715	COG0542	response to heat
I6I45_RS02730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I45_RS02735	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I45_RS02740	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I45_RS02745	COG1674	ftsk spoiiie
I6I45_RS02750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I45_RS02755	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I45_RS02760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I45_RS02765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I45_RS02770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I45_RS02770	COG1648	precorrin-2 dehydrogenase activity
I6I45_RS02775	COG0435	Glutathione S-transferase
I6I45_RS02780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I45_RS02785	COG2920	part of a sulfur-relay system
I6I45_RS02805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I45_RS02810	COG3091	SprT-like family
I6I45_RS02820	COG0037	tRNA processing
I6I45_RS02825	COG2818	Glycosylase
I6I45_RS02840	COG1393	Belongs to the ArsC family
I6I45_RS02860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I45_RS02865	COG0784	Response regulator, receiver
I6I45_RS02865	COG5002	protein histidine kinase activity
I6I45_RS02865	COG2205	protein histidine kinase activity
I6I45_RS02885	COG0658	competence protein
I6I45_RS02885	COG2333	competence protein COMEC
I6I45_RS02890	COG0811	peptide transport
I6I45_RS02895	COG0848	biopolymer transport protein
I6I45_RS02900	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I45_RS02905	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I45_RS02910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I45_RS02915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I45_RS02920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I45_RS02970	COG3284	Transcriptional regulator
I6I45_RS02975	COG3842	ATPase activity
I6I45_RS02980	COG3842	ATPase activity
I6I45_RS02990	COG0395	ABC-type sugar transport system, permease component
I6I45_RS03020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I45_RS03025	COG1063	alcohol dehydrogenase
I6I45_RS03050	COG2814	Major facilitator Superfamily
I6I45_RS03160	COG1177	transmembrane transport
I6I45_RS03165	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I45_RS03170	COG3842	ATPase activity
I6I45_RS03175	COG1414	Transcriptional regulator
I6I45_RS03180	COG0534	Mate efflux family protein
I6I45_RS03185	COG1309	transcriptional regulator
I6I45_RS03270	COG1741	Belongs to the pirin family
I6I45_RS03290	COG1917	Cupin 2, conserved barrel domain protein
I6I45_RS03290	COG4977	sequence-specific DNA binding
I6I45_RS03305	COG1999	signal sequence binding
I6I45_RS03350	COG0693	protein deglycase activity
I6I45_RS03370	COG2207	Transcriptional regulator
I6I45_RS03385	COG2066	Belongs to the glutaminase family
I6I45_RS03395	COG0019	diaminopimelate decarboxylase activity
I6I45_RS03400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I45_RS03420	COG0625	glutathione transferase activity
I6I45_RS03455	COG2205	protein histidine kinase activity
I6I45_RS03460	COG0745	RESPONSE REGULATOR receiver
I6I45_RS03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I45_RS03485	COG3718	enzyme involved in inositol metabolism
I6I45_RS03500	COG0673	inositol 2-dehydrogenase activity
I6I45_RS03505	COG0673	inositol 2-dehydrogenase activity
I6I45_RS03520	COG1129	ABC transporter
I6I45_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I45_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS03595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I45_RS03615	COG2194	sulfuric ester hydrolase activity
I6I45_RS03625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6I45_RS03630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I45_RS03635	COG0561	phosphatase activity
I6I45_RS03710	COG0583	DNA-binding transcription factor activity
I6I45_RS03725	COG2233	PERMEase
I6I45_RS03750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I45_RS03760	COG1609	Transcriptional regulator
I6I45_RS03775	COG3468	outer membrane autotransporter barrel domain protein
I6I45_RS03795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I45_RS03800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS03805	COG0745	RESPONSE REGULATOR receiver
I6I45_RS03810	COG2205	protein histidine kinase activity
I6I45_RS03830	COG0730	response to heat
I6I45_RS03835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I45_RS03840	COG0024	Methionine aminopeptidase
I6I45_RS03865	COG1070	Carbohydrate kinase
I6I45_RS03885	COG1175	transmembrane transport
I6I45_RS03925	COG1538	Outer membrane efflux protein
I6I45_RS03935	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS03940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I45_RS03945	COG0348	domain, Protein
I6I45_RS03955	COG1285	pathogenesis
I6I45_RS03980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I45_RS03990	COG4191	Histidine kinase
I6I45_RS03990	COG0784	Response regulator, receiver
I6I45_RS04000	COG0477	Major facilitator Superfamily
I6I45_RS04005	COG0579	oxidoreductase
I6I45_RS04010	COG2186	Transcriptional regulator
I6I45_RS04015	COG2814	Major facilitator Superfamily
I6I45_RS04045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I45_RS04050	COG3318	Belongs to the UPF0149 family
I6I45_RS04050	COG3012	SEC-C Motif Domain Protein
I6I45_RS04055	COG1024	Enoyl-CoA hydratase
I6I45_RS04060	COG2816	NAD+ diphosphatase activity
I6I45_RS04085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I45_RS04095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I45_RS04100	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I45_RS04140	COG0697	spore germination
I6I45_RS04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I45_RS04160	COG0154	amidase activity
I6I45_RS04170	COG2223	nitrite transmembrane transporter activity
I6I45_RS04175	COG2207	Transcriptional regulator
I6I45_RS04190	COG2207	Transcriptional regulator
I6I45_RS04215	COG2271	Major facilitator Superfamily
I6I45_RS04230	COG0583	DNA-binding transcription factor activity
I6I45_RS04260	COG1335	isochorismatase
I6I45_RS04265	COG1944	ATP diphosphatase activity
I6I45_RS04270	COG0626	cystathionine gamma-synthase activity
I6I45_RS04285	COG2814	Major facilitator Superfamily
I6I45_RS04300	COG1230	cation diffusion facilitator family transporter
I6I45_RS04335	COG0583	DNA-binding transcription factor activity
I6I45_RS04340	COG0840	transmembrane signaling receptor activity
I6I45_RS04395	COG1640	4-alpha-glucanotransferase
I6I45_RS04400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I45_RS04405	COG0297	glycogen (starch) synthase activity
I6I45_RS04410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I45_RS04415	COG0596	Alpha beta hydrolase
I6I45_RS04420	COG1238	metal cluster binding
I6I45_RS04435	COG0667	Aldo Keto reductase
I6I45_RS04440	COG0583	DNA-binding transcription factor activity
I6I45_RS04460	COG1116	anion transmembrane transporter activity
I6I45_RS04465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I45_RS04470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I45_RS04490	COG2366	antibiotic biosynthetic process
I6I45_RS04550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I45_RS04555	COG3938	Belongs to the proline racemase family
I6I45_RS04560	COG0531	amino acid
I6I45_RS04585	COG0583	DNA-binding transcription factor activity
I6I45_RS04590	COG1335	isochorismatase
I6I45_RS04595	COG1335	isochorismatase
I6I45_RS04600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I45_RS04610	COG0581	inorganic phosphate transmembrane transporter activity
I6I45_RS04615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I45_RS04670	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I45_RS04675	COG1169	isochorismate synthase
I6I45_RS04680	COG2226	methyltransferase
I6I45_RS04680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I45_RS04680	COG3433	isochorismatase activity
I6I45_RS04690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I45_RS04700	COG2375	cellular response to nickel ion
I6I45_RS04700	COG1132	(ABC) transporter
I6I45_RS04710	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I45_RS04715	COG4605	iron ion homeostasis
I6I45_RS04720	COG4604	ABC transporter, ATP-binding protein
I6I45_RS04725	COG4607	ABC-type enterochelin transport system periplasmic component
I6I45_RS04730	COG4774	siderophore transport
I6I45_RS05115	COG3773	Cell wall hydrolase
I6I45_RS05115	COG3409	Peptidoglycan-binding domain 1 protein
I6I45_RS05130	COG2135	peptidase activity
I6I45_RS05195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I45_RS05210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I45_RS05230	COG0488	(ABC) transporter
I6I45_RS05240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I45_RS05260	COG2169	Transcriptional regulator
I6I45_RS05260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I45_RS05265	COG3145	DNA-N1-methyladenine dioxygenase activity
I6I45_RS05345	COG2200	EAL domain
I6I45_RS05350	COG0583	DNA-binding transcription factor activity
I6I45_RS05375	COG0667	Aldo Keto reductase
I6I45_RS05380	COG0583	DNA-binding transcription factor activity
I6I45_RS05390	COG2271	Major facilitator Superfamily
I6I45_RS05395	COG3835	regulator
I6I45_RS05400	COG1929	Belongs to the glycerate kinase type-1 family
I6I45_RS05425	COG1247	-acetyltransferase
I6I45_RS05430	COG1794	racemase activity, acting on amino acids and derivatives
I6I45_RS05450	COG2198	Histidine kinase
I6I45_RS05450	COG2205	protein histidine kinase activity
I6I45_RS05450	COG0784	Response regulator, receiver
I6I45_RS05455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I45_RS05465	COG2205	protein histidine kinase activity
I6I45_RS05465	COG5002	protein histidine kinase activity
I6I45_RS05465	COG0784	Response regulator, receiver
I6I45_RS05485	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6I45_RS05495	COG3781	membrane
I6I45_RS05500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I45_RS05515	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS05520	COG1024	Enoyl-CoA hydratase
I6I45_RS05525	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS05530	COG1024	Enoyl-CoA hydratase
I6I45_RS05555	COG2076	Multidrug Resistance protein
I6I45_RS05560	COG2076	Multidrug Resistance protein
I6I45_RS05565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I45_RS05570	COG0726	polysaccharide deacetylase
I6I45_RS05575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I45_RS05575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I45_RS05580	COG0463	Glycosyl transferase, family 2
I6I45_RS05590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I45_RS05595	COG2814	Major facilitator Superfamily
I6I45_RS05675	COG2205	protein histidine kinase activity
I6I45_RS05710	COG0596	Alpha beta hydrolase
I6I45_RS05715	COG0596	Alpha beta hydrolase
I6I45_RS05720	COG3237	CsbD-like
I6I45_RS05725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I45_RS05730	COG1024	Enoyl-CoA hydratase
I6I45_RS05730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I45_RS05745	COG0583	DNA-binding transcription factor activity
I6I45_RS05755	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS05760	COG0531	amino acid
I6I45_RS05775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I45_RS05785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I45_RS05795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I45_RS05805	COG0826	peptidase U32
I6I45_RS05810	COG0697	spore germination
I6I45_RS05815	COG1522	sequence-specific DNA binding
I6I45_RS05840	COG2308	Evidence 4 Homologs of previously reported genes of
I6I45_RS05850	COG1199	ATP-dependent helicase activity
I6I45_RS05850	COG1199	ATP-dependent helicase activity
I6I45_RS05865	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I45_RS05910	COG1113	amino acid transport
I6I45_RS05935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS05950	COG0210	DNA helicase
I6I45_RS05965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I45_RS05975	COG0604	alcohol dehydrogenase
I6I45_RS05975	COG3321	synthase
I6I45_RS05975	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS06035	COG1538	Outer membrane efflux protein
I6I45_RS06040	COG0583	DNA-binding transcription factor activity
I6I45_RS06065	COG2207	Transcriptional regulator
I6I45_RS06070	COG0672	)-iron permease
I6I45_RS06075	COG2822	iron ion transport
I6I45_RS06085	COG2822	iron ion transport
I6I45_RS06090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I45_RS06105	COG2133	pyrroloquinoline quinone binding
I6I45_RS06115	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6I45_RS06150	COG0488	(ABC) transporter
I6I45_RS06165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I45_RS06170	COG0583	DNA-binding transcription factor activity
I6I45_RS06185	COG1968	undecaprenyl-diphosphatase activity
I6I45_RS06190	COG0840	transmembrane signaling receptor activity
I6I45_RS06220	COG2079	MmgE PrpD family protein
I6I45_RS06225	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS06230	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I45_RS06235	COG0583	DNA-binding transcription factor activity
I6I45_RS06250	COG2205	protein histidine kinase activity
I6I45_RS06255	COG0745	RESPONSE REGULATOR receiver
I6I45_RS06270	COG0589	response to stress
I6I45_RS06305	COG0814	amino acid
I6I45_RS06320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I45_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS06355	COG2818	Glycosylase
I6I45_RS06370	COG2186	Transcriptional regulator
I6I45_RS06385	COG0714	Associated with various cellular activities
I6I45_RS06425	COG0420	3'-5' exonuclease activity
I6I45_RS06445	COG2706	6-phosphogluconolactonase activity
I6I45_RS06465	COG0673	inositol 2-dehydrogenase activity
I6I45_RS06470	COG0318	PFAM AMP-dependent synthetase and ligase
I6I45_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS06490	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS06510	COG3239	Fatty acid desaturase
I6I45_RS06515	COG2267	carboxylic ester hydrolase activity
I6I45_RS06535	COG0308	aminopeptidase N
I6I45_RS06545	COG3139	Protein of unknown function (DUF1315)
I6I45_RS06555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I45_RS06560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I45_RS06590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I45_RS06615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I45_RS06615	COG0316	Belongs to the HesB IscA family
I6I45_RS06625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I45_RS06670	COG0028	Belongs to the TPP enzyme family
I6I45_RS06675	COG0431	NADPH-dependent FMN reductase
I6I45_RS06705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I45_RS06715	COG0328	RNA-DNA hybrid ribonuclease activity
I6I45_RS06725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I45_RS06730	COG1388	LysM domain
I6I45_RS06730	COG0741	lytic transglycosylase activity
I6I45_RS06735	COG4166	transmembrane transport
I6I45_RS06740	COG4166	transmembrane transport
I6I45_RS06745	COG4174	ABC transporter (Permease)
I6I45_RS06750	COG4239	(ABC) transporter, permease
I6I45_RS06755	COG4172	Belongs to the ABC transporter superfamily
I6I45_RS06800	COG0673	inositol 2-dehydrogenase activity
I6I45_RS06845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I45_RS06850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I45_RS06865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I45_RS06880	COG0515	serine threonine protein kinase
I6I45_RS06880	COG2815	serine threonine protein kinase
I6I45_RS06885	COG0631	protein serine/threonine phosphatase activity
I6I45_RS06965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I45_RS06970	COG4166	transmembrane transport
I6I45_RS06975	COG4174	ABC transporter (Permease)
I6I45_RS06980	COG4239	(ABC) transporter, permease
I6I45_RS06985	COG4172	Belongs to the ABC transporter superfamily
I6I45_RS07005	COG3340	Belongs to the peptidase S51 family
I6I45_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS07015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I45_RS07030	COG0154	amidase activity
I6I45_RS07035	COG1082	Xylose isomerase domain protein TIM barrel
I6I45_RS07040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I45_RS07045	COG0534	Mate efflux family protein
I6I45_RS07060	COG2610	gluconate transmembrane transporter activity
I6I45_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS07070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I45_RS07080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I45_RS07085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I45_RS07105	COG1126	abc transporter atp-binding protein
I6I45_RS07110	COG0765	amino acid transport
I6I45_RS07115	COG0765	amino acid transport
I6I45_RS07130	COG1253	flavin adenine dinucleotide binding
I6I45_RS07140	COG0698	ribose 5-phosphate isomerase
I6I45_RS07145	COG1129	ABC transporter
I6I45_RS07150	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I45_RS07155	COG1879	ABC-type sugar transport system periplasmic component
I6I45_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS07165	COG1063	alcohol dehydrogenase
I6I45_RS07170	COG2376	Dihydroxyacetone kinase
I6I45_RS07180	COG0616	signal peptide processing
I6I45_RS07200	COG5383	Protein conserved in bacteria
I6I45_RS07220	COG0784	Response regulator, receiver
I6I45_RS07220	COG4191	Histidine kinase
I6I45_RS07225	COG0587	DNA-directed DNA polymerase activity
I6I45_RS07240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I45_RS07245	COG0494	nUDIX hydrolase
I6I45_RS07255	COG1304	FMN binding
I6I45_RS07260	COG1349	DNA-binding transcription factor activity
I6I45_RS07265	COG0583	DNA-binding transcription factor activity
I6I45_RS07275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I45_RS07285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I45_RS07305	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I6I45_RS07325	COG5001	Diguanylate cyclase
I6I45_RS07325	COG5002	protein histidine kinase activity
I6I45_RS07325	COG3447	MASE1 domain protein
I6I45_RS07335	COG0583	DNA-binding transcription factor activity
I6I45_RS07340	COG1335	isochorismatase
I6I45_RS07345	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I45_RS07355	COG2072	flavoprotein involved in K transport
I6I45_RS07375	COG0583	DNA-binding transcription factor activity
I6I45_RS07380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I45_RS07410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I45_RS07415	COG0596	Alpha beta hydrolase
I6I45_RS07425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I45_RS07430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I45_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS07450	COG0583	DNA-binding transcription factor activity
I6I45_RS07455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS07465	COG0174	glutamine synthetase
I6I45_RS07480	COG2814	Major facilitator Superfamily
I6I45_RS07490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I45_RS07505	COG2814	Major facilitator Superfamily
I6I45_RS07510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS07515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I45_RS07520	COG3209	COG3209 Rhs family protein
I6I45_RS07520	COG3209	COG3209 Rhs family protein
I6I45_RS07545	COG3706	GGDEF domain
I6I45_RS07550	COG1280	lysine exporter protein (LysE YggA)
I6I45_RS07565	COG2188	Transcriptional regulator
I6I45_RS07570	COG1522	sequence-specific DNA binding
I6I45_RS07595	COG0475	glutathione-regulated potassium exporter activity
I6I45_RS07595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I45_RS07625	COG0318	PFAM AMP-dependent synthetase and ligase
I6I45_RS07660	COG3321	synthase
I6I45_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS07660	COG0604	alcohol dehydrogenase
I6I45_RS07665	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS07685	COG1968	undecaprenyl-diphosphatase activity
I6I45_RS07730	COG0625	glutathione transferase activity
I6I45_RS07755	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I45_RS07760	COG1129	ABC transporter
I6I45_RS07765	COG1879	ABC-type sugar transport system periplasmic component
I6I45_RS07775	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS07815	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS07820	COG0640	Transcriptional regulator
I6I45_RS07825	COG2199	diguanylate cyclase activity
I6I45_RS07835	COG3781	membrane
I6I45_RS07855	COG2207	Transcriptional regulator
I6I45_RS07855	COG1609	Transcriptional regulator
I6I45_RS07860	COG2115	Belongs to the xylose isomerase family
I6I45_RS07865	COG4213	ABC transporter substrate-binding protein
I6I45_RS07870	COG1129	ABC transporter
I6I45_RS07875	COG4214	carbohydrate transport
I6I45_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS07915	COG4774	siderophore transport
I6I45_RS07920	COG2814	Major facilitator Superfamily
I6I45_RS07925	COG1595	DNA-templated transcription, initiation
I6I45_RS07930	COG3712	iron ion homeostasis
I6I45_RS07935	COG4774	siderophore transport
I6I45_RS07945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I45_RS07975	COG2323	membrane
I6I45_RS08000	COG5001	Diguanylate cyclase
I6I45_RS08000	COG3706	GGDEF domain
I6I45_RS08000	COG2203	Gaf domain
I6I45_RS08000	COG4251	negative regulation of phosphorylation
I6I45_RS08040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I45_RS08050	COG1845	cytochrome c oxidase, subunit III
I6I45_RS08060	COG0109	protoheme IX farnesyltransferase activity
I6I45_RS08065	COG0784	Response regulator, receiver
I6I45_RS08065	COG4191	Histidine kinase
I6I45_RS08070	COG3685	Protein conserved in bacteria
I6I45_RS08075	COG3546	catalase activity
I6I45_RS08100	COG3121	Chaperone
I6I45_RS08110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS08110	COG2205	protein histidine kinase activity
I6I45_RS08115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS08115	COG2198	Histidine kinase
I6I45_RS08115	COG2205	protein histidine kinase activity
I6I45_RS08115	COG0784	Response regulator, receiver
I6I45_RS08120	COG2197	response regulator
I6I45_RS08130	COG5001	Diguanylate cyclase
I6I45_RS08130	COG4251	negative regulation of phosphorylation
I6I45_RS08130	COG3706	GGDEF domain
I6I45_RS08130	COG2203	Gaf domain
I6I45_RS08145	COG2205	protein histidine kinase activity
I6I45_RS08145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS08150	COG5001	Diguanylate cyclase
I6I45_RS08155	COG2197	response regulator
I6I45_RS08170	COG3188	usher protein
I6I45_RS08215	COG1546	Belongs to the CinA family
I6I45_RS08215	COG1058	Belongs to the CinA family
I6I45_RS08235	COG4221	oxidoreductase activity
I6I45_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS08280	COG4221	oxidoreductase activity
I6I45_RS08285	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS08290	COG1309	transcriptional regulator
I6I45_RS08295	COG1301	dicarboxylic acid transport
I6I45_RS08305	COG0583	DNA-binding transcription factor activity
I6I45_RS08315	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I45_RS08325	COG2207	Transcriptional regulator
I6I45_RS08360	COG0322	excinuclease ABC activity
I6I45_RS08365	COG2197	response regulator
I6I45_RS08390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I45_RS08400	COG2205	protein histidine kinase activity
I6I45_RS08400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS08405	COG2197	response regulator
I6I45_RS08415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I45_RS08450	COG2814	Major facilitator Superfamily
I6I45_RS08470	COG0174	glutamine synthetase
I6I45_RS08495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I45_RS08500	COG0517	IMP dehydrogenase activity
I6I45_RS08505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I45_RS08515	COG0583	DNA-binding transcription factor activity
I6I45_RS08520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I45_RS08550	COG3209	COG3209 Rhs family protein
I6I45_RS08560	COG0113	porphobilinogen synthase activity
I6I45_RS08565	COG0384	phenazine biosynthesis protein PhzF
I6I45_RS08570	COG0625	glutathione transferase activity
I6I45_RS08580	COG0701	Predicted permease
I6I45_RS08585	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6I45_RS08590	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I45_RS08595	COG1253	flavin adenine dinucleotide binding
I6I45_RS08605	COG0583	DNA-binding transcription factor activity
I6I45_RS08615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I45_RS08630	COG3132	Protein of unknown function, DUF480
I6I45_RS08635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I45_RS08655	COG0628	permease
I6I45_RS08660	COG0826	peptidase U32
I6I45_RS08670	COG2056	Na+-H+ antiporter family
I6I45_RS08675	COG0840	transmembrane signaling receptor activity
I6I45_RS08705	COG0720	synthase
I6I45_RS08710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I45_RS08715	COG0402	S-adenosylhomocysteine deaminase activity
I6I45_RS08720	COG3675	Pfam Lipase (class 3)
I6I45_RS08740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I45_RS08745	COG2223	nitrite transmembrane transporter activity
I6I45_RS08765	COG4772	TonB-dependent receptor
I6I45_RS08775	COG1595	DNA-templated transcription, initiation
I6I45_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS08790	COG3387	PFAM Glycoside hydrolase 15-related
I6I45_RS08795	COG0596	Alpha beta hydrolase
I6I45_RS08800	COG4977	sequence-specific DNA binding
I6I45_RS08820	COG1595	DNA-templated transcription, initiation
I6I45_RS08825	COG3712	iron ion homeostasis
I6I45_RS08840	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6I45_RS08840	COG0662	Cupin 2, conserved barrel domain protein
I6I45_RS08870	COG0438	transferase activity, transferring glycosyl groups
I6I45_RS08890	COG0728	peptidoglycan biosynthetic process
I6I45_RS08905	COG0417	DNA replication proofreading
I6I45_RS08925	COG0768	penicillin binding
I6I45_RS08955	COG5006	permease, DMT superfamily
I6I45_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS08990	COG3829	transcription factor binding
I6I45_RS09020	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I45_RS09025	COG1509	lysine 2,3-aminomutase activity
I6I45_RS09055	COG1121	(ABC) transporter
I6I45_RS09060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I45_RS09085	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I45_RS09095	COG3842	ATPase activity
I6I45_RS09110	COG2200	EAL domain
I6I45_RS09130	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I45_RS09135	COG2010	Cytochrome c
I6I45_RS09165	COG2974	May be involved in recombination
I6I45_RS09170	COG0385	Bile acid
I6I45_RS09180	COG2076	Multidrug Resistance protein
I6I45_RS09195	COG0477	Major facilitator Superfamily
I6I45_RS09215	COG0842	Transport permease protein
I6I45_RS09220	COG1131	(ABC) transporter
I6I45_RS09225	COG0625	glutathione transferase activity
I6I45_RS09235	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS09250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I45_RS09255	COG3540	Alkaline phosphatase
I6I45_RS09280	COG0811	peptide transport
I6I45_RS09305	COG0786	glutamate:sodium symporter activity
I6I45_RS09315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I45_RS09320	COG2197	response regulator
I6I45_RS09355	COG0840	transmembrane signaling receptor activity
I6I45_RS09370	COG2130	NADP-dependent
I6I45_RS09375	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I45_RS09390	COG0628	permease
I6I45_RS09415	COG1022	Amp-dependent synthetase and ligase
I6I45_RS09430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I45_RS09435	COG4771	TonB-dependent receptor
I6I45_RS09445	COG0784	Response regulator, receiver
I6I45_RS09445	COG5002	protein histidine kinase activity
I6I45_RS09445	COG2205	protein histidine kinase activity
I6I45_RS09450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I45_RS09475	COG1741	Belongs to the pirin family
I6I45_RS09485	COG0326	Molecular chaperone. Has ATPase activity
I6I45_RS09520	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I45_RS09525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I45_RS09540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I45_RS09545	COG1053	succinate dehydrogenase
I6I45_RS09550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I45_RS09555	COG2009	succinate dehydrogenase
I6I45_RS09565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I45_RS09570	COG3162	membrane
I6I45_RS09575	COG2113	Glycine betaine
I6I45_RS09595	COG2853	Lipoprotein
I6I45_RS09605	COG2354	Protein conserved in bacteria
I6I45_RS09610	COG1309	transcriptional regulator
I6I45_RS09625	COG3960	tartronate-semialdehyde synthase activity
I6I45_RS09630	COG3622	Belongs to the hyi family
I6I45_RS09635	COG2084	Dehydrogenase
I6I45_RS09645	COG0469	pyruvate kinase activity
I6I45_RS09655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I45_RS09665	COG2814	Major facilitator Superfamily
I6I45_RS09675	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I45_RS09680	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I45_RS09685	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I45_RS09690	COG0477	Major facilitator Superfamily
I6I45_RS09700	COG4235	cytochrome complex assembly
I6I45_RS09705	COG3088	subunit of a heme lyase
I6I45_RS09715	COG1138	Cytochrome C-type biogenesis protein
I6I45_RS09720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I45_RS09740	COG4133	protoheme IX ABC transporter activity
I6I45_RS09750	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I45_RS09755	COG0303	'Molybdopterin
I6I45_RS09760	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I45_RS09765	COG0746	molybdenum cofactor guanylyltransferase activity
I6I45_RS09775	COG0564	pseudouridine synthase activity
I6I45_RS09795	COG0004	ammonium transporteR
I6I45_RS09825	COG2197	response regulator
I6I45_RS09835	COG1956	GAF domain-containing protein
I6I45_RS09850	COG0386	Belongs to the glutathione peroxidase family
I6I45_RS09855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I45_RS09860	COG0436	Aminotransferase
I6I45_RS09865	COG0501	Belongs to the peptidase M48B family
I6I45_RS09870	COG0500	methyltransferase
I6I45_RS09875	COG3384	dioxygenase
I6I45_RS09895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I45_RS09900	COG3214	Protein conserved in bacteria
I6I45_RS09910	COG0583	DNA-binding transcription factor activity
I6I45_RS09920	COG0583	DNA-binding transcription factor activity
I6I45_RS09925	COG1846	Transcriptional regulator
I6I45_RS09930	COG1764	response to oxidative stress
I6I45_RS09935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I45_RS09950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I45_RS09970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I45_RS10000	COG1376	ErfK ybiS ycfS ynhG family protein
I6I45_RS10015	COG4181	ATPase activity
I6I45_RS10020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I45_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS10110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I45_RS10135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I45_RS10180	COG0745	RESPONSE REGULATOR receiver
I6I45_RS10185	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6I45_RS10210	COG2433	Pfam Transposase IS66
I6I45_RS10330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I45_RS10340	COG1131	(ABC) transporter
I6I45_RS10365	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I45_RS10370	COG0084	hydrolase, TatD family'
I6I45_RS10380	COG3209	COG3209 Rhs family protein
I6I45_RS10415	COG0745	RESPONSE REGULATOR receiver
I6I45_RS10420	COG2205	protein histidine kinase activity
I6I45_RS10425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I45_RS10435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I45_RS10470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I45_RS10475	COG1555	photosystem II stabilization
I6I45_RS10485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I45_RS10495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I45_RS10515	COG1086	Polysaccharide biosynthesis protein
I6I45_RS10525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I45_RS10530	COG0482	sulfurtransferase activity
I6I45_RS10595	COG0776	regulation of translation
I6I45_RS10605	COG3344	reverse transcriptase
I6I45_RS10615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I45_RS10620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I45_RS10625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I45_RS10635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I45_RS10645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I45_RS10650	COG0402	S-adenosylhomocysteine deaminase activity
I6I45_RS10655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I45_RS10660	COG0546	phosphoglycolate phosphatase activity
I6I45_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS10670	COG0747	negative chemotaxis
I6I45_RS10675	COG4608	Belongs to the ABC transporter superfamily
I6I45_RS10680	COG0444	Belongs to the ABC transporter superfamily
I6I45_RS10685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I45_RS10695	COG0596	Alpha beta hydrolase
I6I45_RS10700	COG2197	response regulator
I6I45_RS10705	COG2267	carboxylic ester hydrolase activity
I6I45_RS10710	COG2233	PERMEase
I6I45_RS10720	COG2814	Major facilitator Superfamily
I6I45_RS10725	COG0583	DNA-binding transcription factor activity
I6I45_RS10730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I45_RS10735	COG0583	DNA-binding transcription factor activity
I6I45_RS10745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I45_RS10755	COG1611	Belongs to the LOG family
I6I45_RS10775	COG0583	DNA-binding transcription factor activity
I6I45_RS10785	COG0579	oxidoreductase
I6I45_RS10790	COG2814	Major facilitator Superfamily
I6I45_RS10820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I45_RS10830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I45_RS10840	COG2204	response regulator
I6I45_RS10850	COG2853	Lipoprotein
I6I45_RS10865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I45_RS10865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I45_RS10885	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I45_RS10890	COG1136	(ABC) transporter
I6I45_RS10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I45_RS10905	COG0584	glycerophosphoryl diester phosphodiesterase
I6I45_RS10910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I45_RS10925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I45_RS10935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I45_RS10980	COG0183	Belongs to the thiolase family
I6I45_RS10985	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I45_RS10985	COG1024	Enoyl-CoA hydratase
I6I45_RS10995	COG0589	response to stress
I6I45_RS11000	COG0488	(ABC) transporter
I6I45_RS11005	COG0741	lytic transglycosylase activity
I6I45_RS11010	COG1132	(ABC) transporter
I6I45_RS11020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I45_RS11030	COG0425	Belongs to the sulfur carrier protein TusA family
I6I45_RS11035	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I45_RS11050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I45_RS11060	COG0542	response to heat
I6I45_RS11070	COG1984	allophanate hydrolase subunit 2
I6I45_RS11075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I45_RS11080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I45_RS11085	COG0583	DNA-binding transcription factor activity
I6I45_RS11095	COG0121	glutamine amidotransferase
I6I45_RS11105	COG1770	oligopeptidase
I6I45_RS11140	COG2983	Belongs to the UPF0260 family
I6I45_RS11150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I45_RS11155	COG3100	YcgL domain-containing protein
I6I45_RS11170	COG0174	glutamine synthetase
I6I45_RS11180	COG0583	DNA-binding transcription factor activity
I6I45_RS11190	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I45_RS11220	COG0583	DNA-binding transcription factor activity
I6I45_RS11230	COG2910	NAD(P)H-binding
I6I45_RS11235	COG3547	Transposase (IS116 IS110 IS902 family)
I6I45_RS11250	COG2807	transmembrane transport
I6I45_RS11275	COG3246	L-lysine catabolic process to acetate
I6I45_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS11285	COG1802	Transcriptional regulator
I6I45_RS11305	COG0583	DNA-binding transcription factor activity
I6I45_RS11330	COG0477	Major facilitator Superfamily
I6I45_RS11335	COG0583	DNA-binding transcription factor activity
I6I45_RS11340	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I45_RS11375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I45_RS11380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I45_RS11385	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I45_RS11390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I45_RS11400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I45_RS11405	COG0425	Belongs to the sulfur carrier protein TusA family
I6I45_RS11415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I45_RS11445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I45_RS11495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I45_RS11525	COG2267	carboxylic ester hydrolase activity
I6I45_RS11540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I45_RS11585	COG2814	Major facilitator Superfamily
I6I45_RS11590	COG1454	alcohol dehydrogenase
I6I45_RS11600	COG1396	sequence-specific DNA binding
I6I45_RS11605	COG0235	Class ii aldolase
I6I45_RS11610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I45_RS11630	COG1629	transport
I6I45_RS11660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I45_RS11675	COG0154	amidase activity
I6I45_RS11685	COG1473	amidohydrolase
I6I45_RS11720	COG2814	Major facilitator Superfamily
I6I45_RS11725	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS11730	COG2197	response regulator
I6I45_RS11735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I45_RS11735	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I45_RS11750	COG0697	spore germination
I6I45_RS11775	COG1309	transcriptional regulator
I6I45_RS11780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS11805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I45_RS11810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I45_RS11820	COG0477	Major facilitator Superfamily
I6I45_RS11825	COG3485	protocatechuate 3,4-dioxygenase
I6I45_RS11830	COG3485	protocatechuate 3,4-dioxygenase
I6I45_RS11835	COG0183	Belongs to the thiolase family
I6I45_RS11840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I45_RS11845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I45_RS11850	COG2814	Major facilitator Superfamily
I6I45_RS11855	COG1414	Transcriptional regulator
I6I45_RS11865	COG0306	phosphate transporter
I6I45_RS11875	COG0583	DNA-binding transcription factor activity
I6I45_RS11885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I45_RS11895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I45_RS11905	COG2271	Major facilitator Superfamily
I6I45_RS11955	COG3220	belongs to the UPF0276 family
I6I45_RS11970	COG0583	DNA-binding transcription factor activity
I6I45_RS11985	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I45_RS11995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I45_RS12005	COG0259	pyridoxamine-phosphate oxidase activity
I6I45_RS12025	COG1199	ATP-dependent helicase activity
I6I45_RS12045	COG3012	SEC-C Motif Domain Protein
I6I45_RS12055	COG0653	protein targeting
I6I45_RS12060	COG2366	antibiotic biosynthetic process
I6I45_RS12070	COG1793	dna ligase
I6I45_RS12100	COG1201	RNA secondary structure unwinding
I6I45_RS12115	COG0717	Belongs to the dCTP deaminase family
I6I45_RS12120	COG1278	Cold shock
I6I45_RS12135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I45_RS12140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I45_RS12145	COG0585	pseudouridine synthase activity
I6I45_RS12150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I45_RS12155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I45_RS12160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I45_RS12170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I45_RS12180	COG0148	phosphopyruvate hydratase activity
I6I45_RS12185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I45_RS12190	COG0504	CTP synthase activity
I6I45_RS12195	COG0037	tRNA processing
I6I45_RS12200	COG0825	malonyl-CoA metabolic process
I6I45_RS12205	COG0587	DNA-directed DNA polymerase activity
I6I45_RS12210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I45_RS12215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I45_RS12220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I45_RS12225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I45_RS12230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I45_RS12250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I45_RS12260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I45_RS12265	COG0233	cytoplasmic translational termination
I6I45_RS12270	COG0528	UMP kinase activity
I6I45_RS12275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I45_RS12280	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I45_RS12285	COG0024	Methionine aminopeptidase
I6I45_RS12290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I45_RS12295	COG0436	Aminotransferase
I6I45_RS12300	COG0025	NhaP-type Na H and K H
I6I45_RS12305	COG1393	Belongs to the ArsC family
I6I45_RS12310	COG2171	N-acyltransferase activity
I6I45_RS12315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I45_RS12320	COG2166	iron-sulfur cluster assembly
I6I45_RS12325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I45_RS12330	COG1215	transferase activity, transferring glycosyl groups
I6I45_RS12335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I45_RS12340	COG2226	methyltransferase
I6I45_RS12355	COG2937	Belongs to the GPAT DAPAT family
I6I45_RS12380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS12400	COG0742	ribosomal rna small subunit methyltransferase
I6I45_RS12415	COG1801	Protein of unknown function DUF72
I6I45_RS12430	COG0563	adenylate kinase activity
I6I45_RS12435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I45_RS12450	COG2885	chlorophyll binding
I6I45_RS12465	COG1073	alpha beta
I6I45_RS12480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I45_RS12490	COG5001	Diguanylate cyclase
I6I45_RS12490	COG2203	Gaf domain
I6I45_RS12490	COG4251	negative regulation of phosphorylation
I6I45_RS12490	COG3706	GGDEF domain
I6I45_RS12495	COG2201	protein-glutamate methylesterase activity
I6I45_RS12510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I45_RS12510	COG0457	Tetratricopeptide repeat
I6I45_RS12530	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I45_RS12545	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS12550	COG3158	transport of potassium into the cell
I6I45_RS12555	COG3657	addiction module killer protein
I6I45_RS12565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I45_RS12580	COG4807	Protein conserved in bacteria
I6I45_RS12595	COG0583	DNA-binding transcription factor activity
I6I45_RS12610	COG3148	PFAM DTW domain containing protein
I6I45_RS12625	COG2137	regulation of response to DNA damage stimulus
I6I45_RS12635	COG1546	Belongs to the CinA family
I6I45_RS12640	COG3179	chitinase
I6I45_RS12745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I45_RS12745	COG0473	3-isopropylmalate dehydrogenase activity
I6I45_RS12750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I45_RS12765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I45_RS12770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I45_RS12775	COG0489	protein tyrosine kinase activity
I6I45_RS12780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I45_RS12780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I45_RS12785	COG2878	Part of a membrane complex involved in electron transport
I6I45_RS12790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I45_RS12800	COG2197	response regulator
I6I45_RS12805	COG0137	argininosuccinate synthase activity
I6I45_RS12815	COG0418	dihydroorotase activity
I6I45_RS12820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I45_RS12825	COG0450	alkyl hydroperoxide reductase
I6I45_RS12840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I45_RS12845	COG0243	molybdopterin cofactor binding
I6I45_RS12850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I45_RS12855	COG3842	ATPase activity
I6I45_RS12860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I45_RS12870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I45_RS12885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS12890	COG0765	amino acid transport
I6I45_RS12895	COG0765	amino acid transport
I6I45_RS12900	COG1126	abc transporter atp-binding protein
I6I45_RS12925	COG4191	Histidine kinase
I6I45_RS12940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I45_RS12955	COG2076	Multidrug Resistance protein
I6I45_RS12975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I45_RS12985	COG0583	DNA-binding transcription factor activity
I6I45_RS12995	COG0494	nUDIX hydrolase
I6I45_RS13000	COG2204	response regulator
I6I45_RS13010	COG1858	cytochrome C peroxidase
I6I45_RS13015	COG3290	protein histidine kinase activity
I6I45_RS13025	COG0254	rRNA binding
I6I45_RS13030	COG0069	glutamate synthase activity
I6I45_RS13055	COG1113	amino acid transport
I6I45_RS13100	COG1695	Transcriptional regulator
I6I45_RS13105	COG2375	cellular response to nickel ion
I6I45_RS13115	COG4628	conserved protein (DUF2132)
I6I45_RS13120	COG4206	TonB-dependent receptor
I6I45_RS13150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I45_RS13165	COG2226	methyltransferase
I6I45_RS13170	COG0500	methyltransferase
I6I45_RS13175	COG0590	tRNA wobble adenosine to inosine editing
I6I45_RS13185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I45_RS13190	COG1381	Involved in DNA repair and RecF pathway recombination
I6I45_RS13195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I45_RS13200	COG0571	ribonuclease III activity
I6I45_RS13205	COG0681	Belongs to the peptidase S26 family
I6I45_RS13210	COG0481	GTPase activity
I6I45_RS13215	COG0795	lipopolysaccharide-transporting ATPase activity
I6I45_RS13220	COG0795	lipopolysaccharide-transporting ATPase activity
I6I45_RS13225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I45_RS13240	COG0525	valine-tRNA ligase activity
I6I45_RS13245	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I45_RS13255	COG3081	Nucleoid-associated protein
I6I45_RS13295	COG1595	DNA-templated transcription, initiation
I6I45_RS13300	COG3712	iron ion homeostasis
I6I45_RS13305	COG4772	TonB-dependent receptor
I6I45_RS13310	COG0583	DNA-binding transcription factor activity
I6I45_RS13315	COG0477	Major facilitator Superfamily
I6I45_RS13325	COG0583	DNA-binding transcription factor activity
I6I45_RS13330	COG1760	l-serine dehydratase
I6I45_RS13335	COG0814	amino acid
I6I45_RS13370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I45_RS13390	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I45_RS13395	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I45_RS13410	COG4774	siderophore transport
I6I45_RS13415	COG2827	Endonuclease containing a URI domain
I6I45_RS13425	COG3539	Fimbrial protein
I6I45_RS13435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS13435	COG2205	protein histidine kinase activity
I6I45_RS13445	COG3539	Fimbrial protein
I6I45_RS13450	COG3539	Fimbrial protein
I6I45_RS13460	COG3121	Chaperone
I6I45_RS13465	COG3188	usher protein
I6I45_RS13480	COG2807	transmembrane transport
I6I45_RS13485	COG2186	Transcriptional regulator
I6I45_RS13500	COG1126	abc transporter atp-binding protein
I6I45_RS13505	COG0765	amino acid transport
I6I45_RS13510	COG4597	amino acid ABC transporter
I6I45_RS13515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS13525	COG0513	Belongs to the DEAD box helicase family
I6I45_RS13535	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I45_RS13540	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I45_RS13550	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I45_RS13560	COG3022	response to hydroperoxide
I6I45_RS13570	COG1215	transferase activity, transferring glycosyl groups
I6I45_RS13575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS13580	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6I45_RS13590	COG3420	alginic acid biosynthetic process
I6I45_RS13605	COG1696	Membrane protein involved in D-alanine export
I6I45_RS13620	COG0662	Cupin 2, conserved barrel domain protein
I6I45_RS13620	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6I45_RS13630	COG0300	oxidoreductase activity
I6I45_RS13640	COG0477	Major facilitator Superfamily
I6I45_RS13650	COG1566	PFAM secretion protein HlyD family protein
I6I45_RS13670	COG0583	DNA-binding transcription factor activity
I6I45_RS13675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I45_RS13680	COG0784	Response regulator, receiver
I6I45_RS13680	COG0835	chemotaxis
I6I45_RS13695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS13720	COG5002	protein histidine kinase activity
I6I45_RS13730	COG5001	Diguanylate cyclase
I6I45_RS13730	COG4251	negative regulation of phosphorylation
I6I45_RS13730	COG2203	Gaf domain
I6I45_RS13730	COG3706	GGDEF domain
I6I45_RS13735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6I45_RS13740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I45_RS13755	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I45_RS13760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I45_RS13765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I45_RS13770	COG0772	Belongs to the SEDS family
I6I45_RS13775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I45_RS13780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I45_RS13785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I45_RS13790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I45_RS13805	COG0275	rRNA processing
I6I45_RS13810	COG2001	Belongs to the MraZ family
I6I45_RS13830	COG0792	nuclease activity
I6I45_RS13835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I45_RS13840	COG2823	Periplasmic or secreted lipoprotein
I6I45_RS13845	COG2885	chlorophyll binding
I6I45_RS13850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I45_RS13860	COG2995	paraquat-inducible protein a
I6I45_RS13865	COG3008	intermembrane lipid transfer
I6I45_RS13875	COG2909	trisaccharide binding
I6I45_RS13895	COG0318	PFAM AMP-dependent synthetase and ligase
I6I45_RS13900	COG1280	lysine exporter protein (LysE YggA)
I6I45_RS13905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I45_RS13910	COG2813	Specifically methylates the guanine in position
I6I45_RS13915	COG2119	membrane
I6I45_RS13920	COG0501	Belongs to the peptidase M48B family
I6I45_RS13925	COG2135	peptidase activity
I6I45_RS13980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I45_RS13985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I45_RS13995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I45_RS14000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I45_RS14005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I45_RS14010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I45_RS14030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I45_RS14035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I45_RS14040	COG1127	ABC transporter
I6I45_RS14050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I45_RS14060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I45_RS14065	COG1137	ATPase activity
I6I45_RS14070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I45_RS14085	COG1660	Displays ATPase and GTPase activities
I6I45_RS14120	COG0312	modulator of DNA gyrase
I6I45_RS14125	COG3028	Belongs to the UPF0307 family
I6I45_RS14130	COG0312	modulator of DNA gyrase
I6I45_RS14135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I45_RS14145	COG1530	ribonuclease E activity
I6I45_RS14150	COG0424	maF-like protein
I6I45_RS14160	COG1792	Involved in formation and maintenance of cell shape
I6I45_RS14165	COG1077	Cell shape determining protein MreB Mrl
I6I45_RS14170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I45_RS14175	COG0154	amidase activity
I6I45_RS14180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I45_RS14185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I45_RS14195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I45_RS14205	COG2721	sulfolactate sulfo-lyase activity
I6I45_RS14210	COG2271	Major facilitator Superfamily
I6I45_RS14220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I45_RS14230	COG2186	Transcriptional regulator
I6I45_RS14235	COG2969	positive regulation of protein catabolic process
I6I45_RS14240	COG0625	glutathione transferase activity
I6I45_RS14245	COG2857	Cytochrome c1
I6I45_RS14250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I45_RS14255	COG0723	plastoquinol--plastocyanin reductase activity
I6I45_RS14260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I45_RS14265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I45_RS14270	COG0667	Aldo Keto reductase
I6I45_RS14275	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS14285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I45_RS14290	COG0180	Tryptophanyl-tRNA synthetase
I6I45_RS14310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I45_RS14330	COG0747	negative chemotaxis
I6I45_RS14335	COG0747	negative chemotaxis
I6I45_RS14340	COG0747	negative chemotaxis
I6I45_RS14350	COG0747	negative chemotaxis
I6I45_RS14355	COG0601	transmembrane transport
I6I45_RS14360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I45_RS14365	COG0444	Belongs to the ABC transporter superfamily
I6I45_RS14370	COG4608	Belongs to the ABC transporter superfamily
I6I45_RS14385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I45_RS14410	COG0019	diaminopimelate decarboxylase activity
I6I45_RS14420	COG3128	pkhd-type hydroxylase
I6I45_RS14425	COG4774	siderophore transport
I6I45_RS14430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I45_RS14440	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I45_RS14440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I45_RS14440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I45_RS14445	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I45_RS14455	COG1609	Transcriptional regulator
I6I45_RS14460	COG0084	hydrolase, TatD family'
I6I45_RS14480	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I45_RS14520	COG0237	dephospho-CoA kinase activity
I6I45_RS14525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I45_RS14550	COG1252	NADH dehydrogenase
I6I45_RS14560	COG2894	cell division
I6I45_RS14585	COG0305	Participates in initiation and elongation during chromosome replication
I6I45_RS14600	COG3081	Nucleoid-associated protein
I6I45_RS14655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I45_RS14665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I45_RS14675	COG0431	NADPH-dependent FMN reductase
I6I45_RS14685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I45_RS14690	COG0640	Transcriptional regulator
I6I45_RS14845	COG1074	ATP-dependent DNA helicase activity
I6I45_RS14910	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I45_RS14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS14970	COG1815	bacterial-type flagellum-dependent cell motility
I6I45_RS15005	COG1230	cation diffusion facilitator family transporter
I6I45_RS15020	COG3436	PFAM IS66 Orf2 family protein
I6I45_RS15025	COG4372	Transposase
I6I45_RS15110	COG0463	Glycosyl transferase, family 2
I6I45_RS15120	COG1280	lysine exporter protein (LysE YggA)
I6I45_RS15185	COG1815	bacterial-type flagellum-dependent cell motility
I6I45_RS15220	COG1230	cation diffusion facilitator family transporter
I6I45_RS15230	COG2814	Major facilitator Superfamily
I6I45_RS15240	COG1238	metal cluster binding
I6I45_RS15270	COG3344	reverse transcriptase
I6I45_RS15325	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I45_RS15350	COG0542	response to heat
I6I45_RS15375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS15390	COG4966	pilus assembly protein PilW
I6I45_RS15405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I45_RS15410	COG1047	Peptidyl-prolyl cis-trans
I6I45_RS15415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I45_RS15420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I45_RS15425	COG0196	riboflavin kinase activity
I6I45_RS15435	COG0268	Binds directly to 16S ribosomal RNA
I6I45_RS15450	COG0857	belongs to the CobB CobQ family
I6I45_RS15450	COG0280	phosphate acetyltransferase
I6I45_RS15455	COG0204	Acyl-transferase
I6I45_RS15465	COG0175	sulfate reduction
I6I45_RS15475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I45_RS15485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I45_RS15490	COG1090	epimerase
I6I45_RS15495	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6I45_RS15510	COG0789	Transcriptional regulator
I6I45_RS15515	COG0415	Belongs to the DNA photolyase family
I6I45_RS15525	COG4221	oxidoreductase activity
I6I45_RS15540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I45_RS15560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I45_RS15565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I45_RS15575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I45_RS15580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I45_RS15590	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I45_RS15595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I45_RS15605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I45_RS15610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I45_RS15615	COG0193	aminoacyl-tRNA hydrolase activity
I6I45_RS15635	COG4669	(LipO)protein
I6I45_RS15670	COG4792	protein secretion
I6I45_RS15680	COG4794	Type iii secretion
I6I45_RS15705	COG1157	protein secretion by the type III secretion system
I6I45_RS15740	COG0405	Gamma-glutamyltransferase
I6I45_RS15755	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I45_RS15770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I45_RS15825	COG0477	Major facilitator Superfamily
I6I45_RS15830	COG2031	fatty acid transporter
I6I45_RS15850	COG0288	reversible hydration of carbon dioxide
I6I45_RS15860	COG0456	acetyltransferase
I6I45_RS15885	COG3008	intermembrane lipid transfer
I6I45_RS15890	COG2995	paraquat-inducible protein a
I6I45_RS15895	COG2995	paraquat-inducible protein a
I6I45_RS15940	COG2233	PERMEase
I6I45_RS15945	COG1309	transcriptional regulator
I6I45_RS15965	COG0387	Pfam Sodium calcium exchanger
I6I45_RS15970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I45_RS15975	COG0477	Major facilitator Superfamily
I6I45_RS15985	COG0583	DNA-binding transcription factor activity
I6I45_RS15990	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I45_RS15995	COG0604	alcohol dehydrogenase
I6I45_RS16005	COG2814	Major facilitator Superfamily
I6I45_RS16020	COG2217	Heavy metal translocating P-type atpase
I6I45_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS16075	COG4964	Belongs to the GSP D family
I6I45_RS16145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I45_RS16155	COG4953	penicillin-binding protein 1C
I6I45_RS16165	COG2373	Large extracellular alpha-helical protein
I6I45_RS16170	COG0534	Mate efflux family protein
I6I45_RS16175	COG1166	arginine decarboxylase activity
I6I45_RS16180	COG0023	Translation Initiation Factor
I6I45_RS16210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I45_RS16225	COG2264	protein methyltransferase activity
I6I45_RS16235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I45_RS16245	COG0138	bifunctional purine biosynthesis protein purh
I6I45_RS16250	COG0151	Belongs to the GarS family
I6I45_RS16260	COG2095	MarC family integral membrane protein
I6I45_RS16285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I45_RS16335	COG0683	leucine binding
I6I45_RS16350	COG0411	ABC transporter
I6I45_RS16360	COG0829	nickel cation binding
I6I45_RS16365	COG0831	urea catabolic process
I6I45_RS16380	COG0832	Belongs to the urease beta subunit family
I6I45_RS16385	COG0804	urea catabolic process
I6I45_RS16395	COG0484	heat shock protein binding
I6I45_RS16405	COG0443	Heat shock 70 kDa protein
I6I45_RS16425	COG0697	spore germination
I6I45_RS16435	COG2982	Protein involved in outer membrane biogenesis
I6I45_RS16445	COG1309	transcriptional regulator
I6I45_RS16450	COG0791	NLP P60 protein
I6I45_RS16455	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I45_RS16460	COG0830	nickel cation binding
I6I45_RS16465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I45_RS16485	COG4221	oxidoreductase activity
I6I45_RS16515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS16520	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS16525	COG0583	DNA-binding transcription factor activity
I6I45_RS16530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I45_RS16535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I45_RS16555	COG2308	Evidence 4 Homologs of previously reported genes of
I6I45_RS16555	COG2307	Protein conserved in bacteria
I6I45_RS16585	COG1032	radical SAM domain protein
I6I45_RS16590	COG0305	Participates in initiation and elongation during chromosome replication
I6I45_RS16595	COG0359	binds to the 23S rRNA
I6I45_RS16605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I45_RS16610	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I45_RS16615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I45_RS16620	COG0557	exoribonuclease II activity
I6I45_RS16635	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I45_RS16640	COG1178	ABC-type Fe3 transport system permease component
I6I45_RS16645	COG0840	transmembrane signaling receptor activity
I6I45_RS16650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I45_RS16655	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I45_RS16660	COG0330	HflC and HflK could
I6I45_RS16665	COG0330	HflC and HflK could
I6I45_RS16670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I45_RS16675	COG1923	regulation of RNA biosynthetic process
I6I45_RS16680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I45_RS16685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I45_RS16690	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I45_RS16695	COG0802	atpase or kinase
I6I45_RS16700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I45_RS16700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I45_RS16710	COG2860	membrane
I6I45_RS16715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I45_RS16720	COG1162	GTPase activity
I6I45_RS16750	COG0688	phosphatidylethanolamine metabolic process
I6I45_RS16755	COG0560	Phosphoserine phosphatase
I6I45_RS16755	COG3830	Belongs to the UPF0237 family
I6I45_RS16785	COG3150	esterase
I6I45_RS16790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I45_RS16800	COG0494	nUDIX hydrolase
I6I45_RS16810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I45_RS16815	COG1538	Outer membrane efflux protein
I6I45_RS16820	COG1519	Transferase
I6I45_RS16840	COG0667	Aldo Keto reductase
I6I45_RS16850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I45_RS16850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I45_RS16855	COG1132	(ABC) transporter
I6I45_RS16865	COG1215	transferase activity, transferring glycosyl groups
I6I45_RS16870	COG0438	transferase activity, transferring glycosyl groups
I6I45_RS16885	COG2192	nodulation
I6I45_RS16900	COG4772	TonB-dependent receptor
I6I45_RS16905	COG0515	serine threonine protein kinase
I6I45_RS16925	COG0438	transferase activity, transferring glycosyl groups
I6I45_RS16930	COG0859	PFAM glycosyl transferase family 9
I6I45_RS16935	COG0859	PFAM glycosyl transferase family 9
I6I45_RS16940	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I45_RS16960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I45_RS16965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I45_RS16980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I45_RS16985	COG0506	proline dehydrogenase activity
I6I45_RS16985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I45_RS16985	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I45_RS16990	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS17010	COG3263	regulation of cellular component size
I6I45_RS17015	COG3264	Mechanosensitive ion channel
I6I45_RS17015	COG1196	nuclear chromosome segregation
I6I45_RS17020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I45_RS17060	COG3118	belongs to the thioredoxin family
I6I45_RS17070	COG1192	Involved in chromosome partitioning
I6I45_RS17085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I45_RS17090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I45_RS17100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I45_RS17115	COG2986	histidine ammonia-lyase
I6I45_RS17140	COG2226	methyltransferase
I6I45_RS17150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I45_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS17165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I45_RS17175	COG0583	DNA-binding transcription factor activity
I6I45_RS17180	COG2814	Major facilitator Superfamily
I6I45_RS17185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I45_RS17190	COG0493	'glutamate synthase
I6I45_RS17195	COG0067	glutamate synthase
I6I45_RS17195	COG0069	glutamate synthase activity
I6I45_RS17195	COG0070	glutamate synthase
I6I45_RS17205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I45_RS17210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I45_RS17240	COG0281	malic enzyme
I6I45_RS17250	COG0254	rRNA binding
I6I45_RS17255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I45_RS17260	COG0018	arginyl-trna synthetase
I6I45_RS17270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I45_RS17275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I45_RS17305	COG2197	response regulator
I6I45_RS17315	COG3121	Chaperone
I6I45_RS17320	COG3121	Chaperone
I6I45_RS17355	COG2226	methyltransferase
I6I45_RS17365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I45_RS17370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I45_RS17375	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I45_RS17380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I45_RS17385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I45_RS17400	COG0840	transmembrane signaling receptor activity
I6I45_RS17405	COG0840	transmembrane signaling receptor activity
I6I45_RS17410	COG1126	abc transporter atp-binding protein
I6I45_RS17415	COG0765	amino acid transport
I6I45_RS17425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS17430	COG2943	transferase activity, transferring hexosyl groups
I6I45_RS17435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I45_RS17440	COG1490	D-aminoacyl-tRNA deacylase activity
I6I45_RS17445	COG0596	Alpha beta hydrolase
I6I45_RS17455	COG1228	amidohydrolase
I6I45_RS17460	COG1113	amino acid transport
I6I45_RS17465	COG2986	histidine ammonia-lyase
I6I45_RS17470	COG2986	histidine ammonia-lyase
I6I45_RS17475	COG4175	Glycine betaine
I6I45_RS17475	COG0517	IMP dehydrogenase activity
I6I45_RS17480	COG4176	ABC-type proline glycine betaine transport system permease component
I6I45_RS17490	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I45_RS17495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I45_RS17505	COG2188	Transcriptional regulator
I6I45_RS17510	COG0402	S-adenosylhomocysteine deaminase activity
I6I45_RS17535	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I45_RS17540	COG0058	SHG alpha-glucan phosphorylase activity
I6I45_RS17550	COG1217	gtp-binding protein TYPA
I6I45_RS17555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I45_RS17555	COG0301	tRNA thio-modification
I6I45_RS17570	COG3852	Histidine kinase
I6I45_RS17590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I45_RS17600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I45_RS17605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I45_RS17610	COG4942	peptidase
I6I45_RS17615	COG0793	Belongs to the peptidase S41A family
I6I45_RS17620	COG2861	carbohydrate metabolic process
I6I45_RS17630	COG0107	imidazoleglycerol-phosphate synthase activity
I6I45_RS17635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I45_RS17645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I45_RS17650	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I45_RS17655	COG2223	nitrite transmembrane transporter activity
I6I45_RS17665	COG1194	a g-specific adenine glycosylase
I6I45_RS17670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I45_RS17765	COG2957	Belongs to the agmatine deiminase family
I6I45_RS17770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I45_RS17810	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I45_RS17815	COG0494	nUDIX hydrolase
I6I45_RS17820	COG1011	Hydrolase
I6I45_RS17825	COG1652	LysM domain
I6I45_RS17830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I45_RS17835	COG0243	molybdopterin cofactor binding
I6I45_RS17850	COG0514	ATP-dependent DNA helicase (RecQ)
I6I45_RS17865	COG2184	nucleotidyltransferase activity
I6I45_RS17890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I45_RS17895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I45_RS17905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I45_RS17910	COG2203	Gaf domain
I6I45_RS17910	COG2200	EAL domain
I6I45_RS17910	COG2199	diguanylate cyclase activity
I6I45_RS17915	COG4067	protein conserved in archaea
I6I45_RS17915	COG0189	ligase activity
I6I45_RS17920	COG0189	ligase activity
I6I45_RS17935	COG2183	response to ionizing radiation
I6I45_RS17945	COG2918	glutathione biosynthetic process
I6I45_RS17950	COG4521	taurine ABC transporter
I6I45_RS17955	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I45_RS17960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I45_RS17965	COG2175	clavaminate synthase activity
I6I45_RS17975	COG0667	Aldo Keto reductase
I6I45_RS17980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I45_RS17985	COG1045	serine acetyltransferase
I6I45_RS17990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I45_RS17995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS18000	COG0765	amino acid transport
I6I45_RS18005	COG1126	abc transporter atp-binding protein
I6I45_RS18035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I45_RS18040	COG2011	ABC-type metal ion transport system permease component
I6I45_RS18080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS18085	COG1126	abc transporter atp-binding protein
I6I45_RS18090	COG0765	amino acid transport
I6I45_RS18095	COG0765	amino acid transport
I6I45_RS18135	COG0583	DNA-binding transcription factor activity
I6I45_RS18140	COG0590	tRNA wobble adenosine to inosine editing
I6I45_RS18145	COG2807	transmembrane transport
I6I45_RS18150	COG4771	TonB-dependent receptor
I6I45_RS18180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I45_RS18185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I45_RS18210	COG2351	hydroxyisourate hydrolase activity
I6I45_RS18225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I45_RS18230	COG4208	sulfate ABC transporter
I6I45_RS18240	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I45_RS18260	COG2199	diguanylate cyclase activity
I6I45_RS18265	COG0745	RESPONSE REGULATOR receiver
I6I45_RS18270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I45_RS18275	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS18325	COG5002	protein histidine kinase activity
I6I45_RS18330	COG0745	RESPONSE REGULATOR receiver
I6I45_RS18360	COG1595	DNA-templated transcription, initiation
I6I45_RS18365	COG2304	oxidoreductase activity
I6I45_RS18440	COG1215	transferase activity, transferring glycosyl groups
I6I45_RS18445	COG1649	PFAM Uncharacterised BCR, COG1649
I6I45_RS18445	COG0726	polysaccharide deacetylase
I6I45_RS18450	COG0457	Tetratricopeptide repeat
I6I45_RS18455	COG5339	Protein conserved in bacteria
I6I45_RS18480	COG1289	transmembrane transporter activity
I6I45_RS18525	COG4774	siderophore transport
I6I45_RS18535	COG1595	DNA-templated transcription, initiation
I6I45_RS18555	COG0583	DNA-binding transcription factor activity
I6I45_RS18560	COG2175	clavaminate synthase activity
I6I45_RS18565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I45_RS18570	COG2274	protein secretion by the type I secretion system
I6I45_RS18590	COG5001	Diguanylate cyclase
I6I45_RS18590	COG3300	MHYT domain
I6I45_RS18600	COG1802	Transcriptional regulator
I6I45_RS18620	COG0840	transmembrane signaling receptor activity
I6I45_RS18660	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS18665	COG0583	DNA-binding transcription factor activity
I6I45_RS18685	COG0427	acetyl-CoA hydrolase
I6I45_RS18715	COG2851	Citrate transporter
I6I45_RS18720	COG0861	Integral membrane protein TerC family
I6I45_RS18725	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I45_RS18730	COG0612	Peptidase, M16
I6I45_RS18740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I45_RS18745	COG1127	ABC transporter
I6I45_RS18760	COG0700	Nucleoside recognition
I6I45_RS18765	COG1301	dicarboxylic acid transport
I6I45_RS18775	COG5487	UPF0391 membrane protein
I6I45_RS18785	COG2204	response regulator
I6I45_RS18790	COG5002	protein histidine kinase activity
I6I45_RS18795	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I45_RS18810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I45_RS18820	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I45_RS18840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6I45_RS18845	COG0735	belongs to the Fur family
I6I45_RS18850	COG1121	(ABC) transporter
I6I45_RS18855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I45_RS18870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I45_RS18875	COG2011	ABC-type metal ion transport system permease component
I6I45_RS18890	COG0109	protoheme IX farnesyltransferase activity
I6I45_RS18920	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6I45_RS18925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I45_RS18930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I45_RS18940	COG0659	secondary active sulfate transmembrane transporter activity
I6I45_RS18980	COG0339	signal peptide processing
I6I45_RS18985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I45_RS19010	COG1764	response to oxidative stress
I6I45_RS19015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I45_RS19025	COG3360	Dodecin
I6I45_RS19045	COG0159	tryptophan synthase activity
I6I45_RS19055	COG2271	Major facilitator Superfamily
I6I45_RS19060	COG4948	Mandelate Racemase Muconate Lactonizing
I6I45_RS19065	COG0800	Aldolase
I6I45_RS19070	COG3734	2-keto-3-deoxy-galactonokinase
I6I45_RS19080	COG0583	DNA-binding transcription factor activity
I6I45_RS19085	COG3119	arylsulfatase activity
I6I45_RS19100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I45_RS19105	COG0408	coproporphyrinogen oxidase activity
I6I45_RS19115	COG0009	L-threonylcarbamoyladenylate synthase
I6I45_RS19120	COG0758	DNA mediated transformation
I6I45_RS19130	COG0242	peptide deformylase activity
I6I45_RS19135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I45_RS19140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I45_RS19145	COG0569	domain protein
I6I45_RS19160	COG2818	Glycosylase
I6I45_RS19165	COG0752	glycyl-tRNA synthetase alpha subunit
I6I45_RS19170	COG0751	glycine-tRNA ligase activity
I6I45_RS19175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I45_RS19185	COG5002	protein histidine kinase activity
I6I45_RS19200	COG0745	RESPONSE REGULATOR receiver
I6I45_RS19205	COG0187	DNA topoisomerase II activity
I6I45_RS19210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I45_RS19215	COG0592	DNA-directed DNA polymerase activity
I6I45_RS19220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I45_RS19225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I45_RS19230	COG0594	ribonuclease P activity
I6I45_RS19235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I45_RS19240	COG0706	membrane insertase activity
I6I45_RS19245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I45_RS19250	COG4774	siderophore transport
I6I45_RS19255	COG3712	iron ion homeostasis
I6I45_RS19260	COG1595	DNA-templated transcription, initiation
I6I45_RS19265	COG0445	tRNA wobble uridine modification
I6I45_RS19270	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I45_RS19275	COG1192	Involved in chromosome partitioning
I6I45_RS19280	COG1475	DNA binding
I6I45_RS19285	COG3312	ion transport
I6I45_RS19290	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I45_RS19300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I45_RS19305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I45_RS19310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I45_RS19315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I45_RS19320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I45_RS19325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I45_RS19330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I45_RS19335	COG1349	DNA-binding transcription factor activity
I6I45_RS19340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I45_RS19350	COG4589	Belongs to the CDS family
I6I45_RS19365	COG2453	phosphatase
I6I45_RS19365	COG0671	phosphoesterase, PA-phosphatase related
I6I45_RS19370	COG2267	carboxylic ester hydrolase activity
I6I45_RS19375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I45_RS19405	COG3220	belongs to the UPF0276 family
I6I45_RS19415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I45_RS19425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I45_RS19435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I45_RS19455	COG1121	(ABC) transporter
I6I45_RS19460	COG1469	GTP cyclohydrolase I activity
I6I45_RS19465	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I45_RS19490	COG0523	cobalamin synthesis protein
I6I45_RS19500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6I45_RS19505	COG1607	acyl-coa hydrolase
I6I45_RS19510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I45_RS19510	COG4651	solute:proton antiporter activity
I6I45_RS19525	COG0210	DNA helicase
I6I45_RS19530	COG5001	Diguanylate cyclase
I6I45_RS19530	COG3300	MHYT domain
I6I45_RS19545	COG0583	DNA-binding transcription factor activity
I6I45_RS19550	COG0439	Biotin carboxylase
I6I45_RS19555	COG0511	ligase activity, forming carbon-carbon bonds
I6I45_RS19555	COG5016	pyruvate
I6I45_RS19580	COG0765	amino acid transport
I6I45_RS19585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS19640	COG0252	asparaginase activity
I6I45_RS19645	COG1115	amino acid carrier protein
I6I45_RS19650	COG1027	Aspartate ammonia-lyase
I6I45_RS19655	COG0583	DNA-binding transcription factor activity
I6I45_RS19685	COG1607	acyl-coa hydrolase
I6I45_RS19690	COG0477	Major facilitator Superfamily
I6I45_RS19705	COG0573	inorganic phosphate transmembrane transporter activity
I6I45_RS19710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I45_RS19715	COG0704	Plays a role in the regulation of phosphate uptake
I6I45_RS19725	COG1253	flavin adenine dinucleotide binding
I6I45_RS19745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I45_RS19750	COG3161	chorismate lyase activity
I6I45_RS19780	COG3209	COG3209 Rhs family protein
I6I45_RS19870	COG0515	serine threonine protein kinase
I6I45_RS19870	COG2815	serine threonine protein kinase
I6I45_RS19875	COG0577	efflux transmembrane transporter activity
I6I45_RS19875	COG1136	(ABC) transporter
I6I45_RS19905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I45_RS19910	COG0583	DNA-binding transcription factor activity
I6I45_RS19920	COG0848	biopolymer transport protein
I6I45_RS19945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I45_RS19950	COG1758	RNA polymerase activity
I6I45_RS19955	COG0194	GDP metabolic process
I6I45_RS19960	COG1561	YicC-like family, N-terminal region
I6I45_RS19965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I45_RS19975	COG0708	Exodeoxyribonuclease III
I6I45_RS19980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I45_RS19985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I45_RS19990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I45_RS19995	COG0756	dUTP diphosphatase activity
I6I45_RS20000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I45_RS20005	COG2003	Belongs to the UPF0758 family
I6I45_RS20010	COG0747	negative chemotaxis
I6I45_RS20015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I45_RS20020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I45_RS20030	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS20040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I45_RS20045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I45_RS20055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS20070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I45_RS20080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I45_RS20095	COG0427	acetyl-CoA hydrolase
I6I45_RS20100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I45_RS20115	COG0534	Mate efflux family protein
I6I45_RS20120	COG0583	DNA-binding transcription factor activity
I6I45_RS20130	COG0606	chelatase, subunit chli
I6I45_RS20140	COG0347	Belongs to the P(II) protein family
I6I45_RS20145	COG0004	ammonium transporteR
I6I45_RS20150	COG0432	Pfam Uncharacterised protein family UPF0047
I6I45_RS20160	COG1011	Hydrolase
I6I45_RS20165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I45_RS20175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I45_RS20180	COG0019	diaminopimelate decarboxylase activity
I6I45_RS20190	COG1965	Belongs to the frataxin family
I6I45_RS20200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I45_RS20220	COG0625	glutathione transferase activity
I6I45_RS20225	COG0165	Argininosuccinate lyase
I6I45_RS20235	COG0181	hydroxymethylbilane synthase activity
I6I45_RS20255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I45_RS20280	COG0488	(ABC) transporter
I6I45_RS20290	COG1280	lysine exporter protein (LysE YggA)
I6I45_RS20295	COG0672	)-iron permease
I6I45_RS20300	COG1671	Belongs to the UPF0178 family
I6I45_RS20305	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I45_RS20315	COG0586	Pfam SNARE associated Golgi protein
I6I45_RS20325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I45_RS20330	COG0248	Ppx GppA phosphatase
I6I45_RS20340	COG3121	Chaperone
I6I45_RS20345	COG3188	usher protein
I6I45_RS20355	COG1126	abc transporter atp-binding protein
I6I45_RS20360	COG0765	amino acid transport
I6I45_RS20365	COG0765	amino acid transport
I6I45_RS20370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS20375	COG2186	Transcriptional regulator
I6I45_RS20395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I45_RS20420	COG2271	Major facilitator Superfamily
I6I45_RS20445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I45_RS20465	COG3079	Belongs to the UPF0149 family
I6I45_RS20470	COG0006	proline dipeptidase activity
I6I45_RS20475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I45_RS20485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I45_RS20495	COG1178	ABC-type Fe3 transport system permease component
I6I45_RS20500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I45_RS20505	COG0509	glycine decarboxylation via glycine cleavage system
I6I45_RS20510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I45_RS20525	COG0330	HflC and HflK could
I6I45_RS20530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I45_RS20540	COG1522	sequence-specific DNA binding
I6I45_RS20555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I45_RS20555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I45_RS20560	COG4521	taurine ABC transporter
I6I45_RS20570	COG0450	alkyl hydroperoxide reductase
I6I45_RS20575	COG0431	NADPH-dependent FMN reductase
I6I45_RS20580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I45_RS20590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I45_RS20595	COG1116	anion transmembrane transporter activity
I6I45_RS20610	COG0174	glutamine synthetase
I6I45_RS20615	COG0174	glutamine synthetase
I6I45_RS20635	COG3842	ATPase activity
I6I45_RS20640	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I45_RS20645	COG1177	transmembrane transport
I6I45_RS20685	COG1683	Conserved Protein
I6I45_RS20690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS20700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I45_RS20705	COG0277	FAD linked oxidase domain protein
I6I45_RS20710	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I45_RS20720	COG3204	pilus organization
I6I45_RS20725	COG2234	aminopeptidase activity
I6I45_RS20730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I45_RS20735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I45_RS20750	COG0494	nUDIX hydrolase
I6I45_RS20755	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6I45_RS20765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I45_RS20770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I45_RS20775	COG0789	Transcriptional regulator
I6I45_RS20785	COG0583	DNA-binding transcription factor activity
I6I45_RS20790	COG3842	ATPase activity
I6I45_RS20795	COG1178	ABC-type Fe3 transport system permease component
I6I45_RS20800	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I45_RS20815	COG1160	GTP binding
I6I45_RS20830	COG1823	symporter activity
I6I45_RS20840	COG0129	dihydroxy-acid dehydratase activity
I6I45_RS20845	COG2814	Major facilitator Superfamily
I6I45_RS20850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I45_RS20860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I45_RS20865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I45_RS20870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I45_RS20875	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I45_RS20890	COG1309	transcriptional regulator
I6I45_RS20900	COG0429	hydrolase of the alpha beta-hydrolase fold
I6I45_RS20905	COG0742	ribosomal rna small subunit methyltransferase
I6I45_RS20910	COG0612	Peptidase, M16
I6I45_RS20915	COG0612	Peptidase, M16
I6I45_RS20920	COG0552	protein localization to endoplasmic reticulum
I6I45_RS20925	COG2884	Cell division ATP-binding protein ftsE
I6I45_RS20930	COG2177	Part of the ABC transporter FtsEX involved in
I6I45_RS20940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I45_RS20945	COG2363	Small membrane protein
I6I45_RS20955	COG2022	thiamine diphosphate biosynthetic process
I6I45_RS20960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I45_RS20970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I45_RS20975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I45_RS20985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I45_RS20985	COG2813	Specifically methylates the guanine in position
I6I45_RS20990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I45_RS21015	COG0791	NLP P60 protein
I6I45_RS21030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I45_RS21035	COG0540	Belongs to the ATCase OTCase family
I6I45_RS21040	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I45_RS21045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I45_RS21050	COG1678	Uncharacterized ACR, COG1678
I6I45_RS21060	COG0189	ligase activity
I6I45_RS21085	COG0643	Histidine kinase
I6I45_RS21085	COG2198	Histidine kinase
I6I45_RS21095	COG3093	addiction module antidote protein HigA
I6I45_RS21140	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6I45_RS21145	COG3052	prosthetic group binding
I6I45_RS21165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I45_RS21185	COG1272	protein, Hemolysin III
I6I45_RS21205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS21210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I45_RS21220	COG3038	cytochrome b561
I6I45_RS21225	COG2353	YceI-like domain
I6I45_RS21230	COG0513	Belongs to the DEAD box helicase family
I6I45_RS21245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I45_RS21250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I45_RS21265	COG2116	formate transmembrane transporter activity
I6I45_RS21270	COG1301	dicarboxylic acid transport
I6I45_RS21315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I45_RS21325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I45_RS21330	COG0640	Transcriptional regulator
I6I45_RS21335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I45_RS21340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I45_RS21345	COG0126	phosphoglycerate kinase activity
I6I45_RS21395	COG1451	nucleotide metabolic process
I6I45_RS21405	COG2153	protein acetylation
I6I45_RS21415	COG1289	transmembrane transporter activity
I6I45_RS21420	COG2081	HI0933 family
I6I45_RS21425	COG0513	Belongs to the DEAD box helicase family
I6I45_RS21430	COG0477	Major facilitator Superfamily
I6I45_RS21450	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I45_RS21455	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS21460	COG1309	transcriptional regulator
I6I45_RS21465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I45_RS21470	COG4175	Glycine betaine
I6I45_RS21485	COG1760	l-serine dehydratase
I6I45_RS21505	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I45_RS21510	COG3246	L-lysine catabolic process to acetate
I6I45_RS21535	COG2304	oxidoreductase activity
I6I45_RS21555	COG1902	pentaerythritol trinitrate reductase activity
I6I45_RS21555	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I45_RS21560	COG2181	nitrate reductase activity
I6I45_RS21560	COG0247	lactate metabolic process
I6I45_RS21565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I45_RS21585	COG4638	Rieske (2fe-2S)
I6I45_RS21590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I45_RS21590	COG1017	nitric oxide dioxygenase activity
I6I45_RS21615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I45_RS21645	COG1063	alcohol dehydrogenase
I6I45_RS21665	COG0204	Acyl-transferase
I6I45_RS21670	COG0189	ligase activity
I6I45_RS21670	COG4067	protein conserved in archaea
I6I45_RS21675	COG0745	RESPONSE REGULATOR receiver
I6I45_RS21680	COG2205	protein histidine kinase activity
I6I45_RS21685	COG4452	Inner membrane protein CreD
I6I45_RS21705	COG4774	siderophore transport
I6I45_RS21715	COG1595	DNA-templated transcription, initiation
I6I45_RS21720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I45_RS21730	COG4566	intracellular signal transduction
I6I45_RS21730	COG0745	RESPONSE REGULATOR receiver
I6I45_RS21735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I45_RS21750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I45_RS21760	COG2005	Transcriptional regulator
I6I45_RS21760	COG3585	molybdate ion transport
I6I45_RS21770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I45_RS21775	COG0156	8-amino-7-oxononanoate synthase activity
I6I45_RS21780	COG2226	methyltransferase
I6I45_RS21780	COG1073	alpha beta
I6I45_RS21800	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS21810	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS21815	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS21820	COG0583	DNA-binding transcription factor activity
I6I45_RS21825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I45_RS21845	COG0535	radical SAM domain protein
I6I45_RS21855	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I6I45_RS21860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I45_RS21870	COG1025	Belongs to the peptidase M16 family
I6I45_RS21875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I45_RS21900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I45_RS21905	COG0358	DNA primase activity
I6I45_RS21910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I45_RS21915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I45_RS21920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I45_RS21925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I45_RS21935	COG0617	tRNA 3'-terminal CCA addition
I6I45_RS21940	COG2719	SpoVR family
I6I45_RS21945	COG2718	Belongs to the UPF0229 family
I6I45_RS21950	COG2766	serine protein kinase
I6I45_RS21955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I45_RS21960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I45_RS21965	COG2967	ApaG domain
I6I45_RS21970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I45_RS21975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I45_RS21980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I45_RS21985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I45_RS21990	COG3178	'Phosphotransferase
I6I45_RS21995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I45_RS22000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I45_RS22010	COG1454	alcohol dehydrogenase
I6I45_RS22015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I45_RS22020	COG0546	phosphoglycolate phosphatase activity
I6I45_RS22030	COG3240	lipase activity
I6I45_RS22030	COG4625	pathogenesis
I6I45_RS22035	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I45_RS22040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I45_RS22045	COG0134	indole-3-glycerol-phosphate synthase activity
I6I45_RS22060	COG1765	OsmC-like protein
I6I45_RS22065	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I45_RS22070	COG0537	adenosine 5'-monophosphoramidase activity
I6I45_RS22075	COG4221	oxidoreductase activity
I6I45_RS22090	COG1981	membrane
I6I45_RS22095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I45_RS22100	COG0316	Belongs to the HesB IscA family
I6I45_RS22105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I45_RS22110	COG0739	heme binding
I6I45_RS22115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I45_RS22145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I45_RS22145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I45_RS22150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I45_RS22190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I45_RS22195	COG0081	regulation of translation
I6I45_RS22200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I45_RS22205	COG0222	ribosome binding
I6I45_RS22210	COG0085	RNA polymerase activity
I6I45_RS22215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I45_RS22220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I45_RS22225	COG0049	tRNA binding
I6I45_RS22230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I45_RS22235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I45_RS22240	COG0051	transcription antitermination factor activity, RNA binding
I6I45_RS22245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I45_RS22250	COG0088	Forms part of the polypeptide exit tunnel
I6I45_RS22255	COG0089	rRNA binding
I6I45_RS22260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I45_RS22265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I45_RS22270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I45_RS22275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I45_RS22280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I45_RS22285	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I45_RS22290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I45_RS22295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I45_RS22300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I45_RS22305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I45_RS22310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I45_RS22315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I45_RS22320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I45_RS22325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I45_RS22330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I45_RS22335	COG1841	ribosomal large subunit assembly
I6I45_RS22340	COG0200	Binds to the 23S rRNA
I6I45_RS22350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I45_RS22355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I45_RS22360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I45_RS22365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I45_RS22370	COG0202	RNA polymerase activity
I6I45_RS22375	COG0203	ribosomal protein L17
I6I45_RS22385	COG2193	ferroxidase activity
I6I45_RS22390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I45_RS22395	COG2814	Major facilitator Superfamily
I6I45_RS22400	COG0629	single-stranded DNA binding
I6I45_RS22405	COG4106	trans-aconitate 2-methyltransferase activity
I6I45_RS22410	COG1335	isochorismatase
I6I45_RS22415	COG2207	Transcriptional regulator
I6I45_RS22415	COG4753	response regulator
I6I45_RS22430	COG0392	lysyltransferase activity
I6I45_RS22435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I45_RS22440	COG3568	Endonuclease Exonuclease Phosphatase
I6I45_RS22450	COG0668	transmembrane transport
I6I45_RS22455	COG1201	RNA secondary structure unwinding
I6I45_RS22495	COG3118	belongs to the thioredoxin family
I6I45_RS22500	COG2264	protein methyltransferase activity
I6I45_RS22510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I45_RS22515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I45_RS22515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I45_RS22530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I45_RS22535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I45_RS22540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I45_RS22550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I45_RS22570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I45_RS22575	COG0142	geranyltranstransferase activity
I6I45_RS22580	COG1722	exodeoxyribonuclease VII activity
I6I45_RS22590	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I45_RS22595	COG4804	nuclease activity
I6I45_RS22605	COG1842	Phage shock protein A
I6I45_RS22625	COG3766	membrane
I6I45_RS22635	COG0754	glutathionylspermidine amidase activity
I6I45_RS22640	COG1335	isochorismatase
I6I45_RS22650	COG3177	Filamentation induced by cAMP protein fic
I6I45_RS22660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I45_RS22665	COG3228	Belongs to the MtfA family
I6I45_RS22670	COG0586	Pfam SNARE associated Golgi protein
I6I45_RS22675	COG0456	acetyltransferase
I6I45_RS22680	COG4302	ethanolamine ammonia-lyase activity
I6I45_RS22685	COG4303	Ethanolamine ammonia lyase large subunit
I6I45_RS22690	COG0531	amino acid
I6I45_RS22700	COG3284	Transcriptional regulator
I6I45_RS22710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I45_RS22725	COG0702	epimerase
I6I45_RS22740	COG1380	Effector of murein hydrolase LrgA
I6I45_RS22745	COG1346	cytolysis
I6I45_RS22760	COG0586	Pfam SNARE associated Golgi protein
I6I45_RS22765	COG2094	Belongs to the DNA glycosylase MPG family
I6I45_RS22770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I45_RS22775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I45_RS22785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I45_RS22790	COG0768	penicillin binding
I6I45_RS22795	COG0772	Belongs to the SEDS family
I6I45_RS22800	COG2951	lytic endotransglycosylase activity
I6I45_RS22810	COG1686	Belongs to the peptidase S11 family
I6I45_RS22815	COG2921	Belongs to the UPF0250 family
I6I45_RS22820	COG0321	lipoyl(octanoyl) transferase activity
I6I45_RS22825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I45_RS22830	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I45_RS22835	COG2951	lytic endotransglycosylase activity
I6I45_RS22845	COG1466	dna polymerase III delta subunit
I6I45_RS22855	COG0495	leucyl-tRNA aminoacylation
I6I45_RS22870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I45_RS22875	COG4535	Mg2 and Co2 transporter CorC
I6I45_RS22880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I45_RS22885	COG1702	phosphate starvation-inducible protein PhoH
I6I45_RS22890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I45_RS22930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I45_RS22935	COG0352	thiamine-phosphate diphosphorylase activity
I6I45_RS22950	COG1960	acyl-CoA dehydrogenase activity
I6I45_RS22955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I45_RS22970	COG1522	sequence-specific DNA binding
I6I45_RS22980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I45_RS22990	COG1643	Atp-dependent helicase
I6I45_RS23005	COG3416	Protein conserved in bacteria
I6I45_RS23015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I45_RS23015	COG1199	ATP-dependent helicase activity
I6I45_RS23025	COG1522	sequence-specific DNA binding
I6I45_RS23030	COG0697	spore germination
I6I45_RS23035	COG0513	Belongs to the DEAD box helicase family
I6I45_RS23045	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I45_RS23055	COG1946	Acyl-CoA thioesterase
I6I45_RS23070	COG2321	neutral zinc metallopeptidase
I6I45_RS23085	COG0477	Major facilitator Superfamily
I6I45_RS23090	COG1082	Xylose isomerase domain protein TIM barrel
I6I45_RS23090	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6I45_RS23095	COG1309	transcriptional regulator
I6I45_RS23100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I45_RS23105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I45_RS23125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I45_RS23130	COG2252	PERMEase
I6I45_RS23140	COG2080	2 iron, 2 sulfur cluster binding
I6I45_RS23145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6I45_RS23150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I45_RS23165	COG1271	oxidase subunit
I6I45_RS23170	COG1294	oxidase, subunit
I6I45_RS23180	COG2813	Specifically methylates the guanine in position
I6I45_RS23195	COG1970	mechanosensitive ion channel activity
I6I45_RS23220	COG1966	Carbon starvation protein
I6I45_RS23225	COG2879	small protein
I6I45_RS23230	COG0523	cobalamin synthesis protein
I6I45_RS23235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I45_RS23245	COG0488	(ABC) transporter
I6I45_RS23250	COG0583	DNA-binding transcription factor activity
I6I45_RS23255	COG2814	Major facilitator Superfamily
I6I45_RS23280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I45_RS23290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I45_RS23310	COG1067	ATP-dependent peptidase activity
I6I45_RS23325	COG2862	Uncharacterized protein family, UPF0114
I6I45_RS23375	COG2003	Belongs to the UPF0758 family
I6I45_RS23385	COG5377	YqaJ viral recombinase family
I6I45_RS23400	COG1942	4-Oxalocrotonate Tautomerase
I6I45_RS23405	COG0583	DNA-binding transcription factor activity
I6I45_RS23415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I45_RS23425	COG2851	Citrate transporter
I6I45_RS23430	COG2301	Belongs to the HpcH HpaI aldolase family
I6I45_RS23440	COG0583	DNA-binding transcription factor activity
I6I45_RS23450	COG2130	NADP-dependent
I6I45_RS23455	COG2188	Transcriptional regulator
I6I45_RS23460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I45_RS23465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I45_RS23480	COG2828	Protein conserved in bacteria
I6I45_RS23495	COG0604	alcohol dehydrogenase
I6I45_RS23500	COG1733	regulation of RNA biosynthetic process
I6I45_RS23525	COG1473	amidohydrolase
I6I45_RS23535	COG0583	DNA-binding transcription factor activity
I6I45_RS23545	COG0582	viral genome integration into host DNA
I6I45_RS23565	COG1620	l-lactate permease
I6I45_RS23570	COG2186	Transcriptional regulator
I6I45_RS23575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I45_RS23585	COG2914	Belongs to the UPF0125 (RnfH) family
I6I45_RS23590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I45_RS23595	COG0735	belongs to the Fur family
I6I45_RS23600	COG0497	DNA recombination
I6I45_RS23605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I45_RS23610	COG0443	Heat shock 70 kDa protein
I6I45_RS23615	COG0484	heat shock protein binding
I6I45_RS23620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I45_RS23625	COG0505	Belongs to the CarA family
I6I45_RS23630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I45_RS23635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I45_RS23650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I45_RS23655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I45_RS23660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I45_RS23665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I45_RS23670	COG0149	triose-phosphate isomerase activity
I6I45_RS23675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I45_RS23690	COG0779	Required for maturation of 30S ribosomal subunits
I6I45_RS23695	COG0195	Participates in both transcription termination and antitermination
I6I45_RS23700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I45_RS23705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I45_RS23710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I45_RS23715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I45_RS23720	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I45_RS23725	COG2823	Periplasmic or secreted lipoprotein
I6I45_RS23735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I45_RS23740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I45_RS23745	COG0166	Belongs to the GPI family
I6I45_RS23750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I45_RS23755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I45_RS23765	COG0617	tRNA 3'-terminal CCA addition
I6I45_RS23775	COG4191	Histidine kinase
I6I45_RS23785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I45_RS23795	COG0436	Aminotransferase
I6I45_RS23800	COG1489	DNA binding
I6I45_RS23810	COG4558	Periplasmic binding protein
I6I45_RS23815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I45_RS23820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I45_RS23840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I45_RS23850	COG3098	single-species biofilm formation
I6I45_RS23855	COG0028	Belongs to the TPP enzyme family
I6I45_RS23865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I45_RS23870	COG1183	phosphatidylcholine synthase activity
I6I45_RS23875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I45_RS23880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I45_RS23910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I45_RS23915	COG1074	ATP-dependent DNA helicase activity
I6I45_RS23920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I45_RS23955	COG0583	DNA-binding transcription factor activity
I6I45_RS23985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I45_RS23990	COG3483	tryptophan 2,3-dioxygenase activity
I6I45_RS23995	COG1113	amino acid transport
I6I45_RS24000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I45_RS24000	COG0543	2 iron, 2 sulfur cluster binding
I6I45_RS24005	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I45_RS24010	COG4638	Rieske (2fe-2S)
I6I45_RS24025	COG4948	Mandelate Racemase Muconate Lactonizing
I6I45_RS24030	COG4829	muconolactone delta-isomerase
I6I45_RS24035	COG3485	protocatechuate 3,4-dioxygenase
I6I45_RS24040	COG1522	sequence-specific DNA binding
I6I45_RS24050	COG1113	amino acid transport
I6I45_RS24055	COG0583	DNA-binding transcription factor activity
I6I45_RS24065	COG0583	DNA-binding transcription factor activity
I6I45_RS24075	COG0659	secondary active sulfate transmembrane transporter activity
I6I45_RS24085	COG2610	gluconate transmembrane transporter activity
I6I45_RS24090	COG1737	Transcriptional regulator
I6I45_RS24095	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I45_RS24105	COG0840	transmembrane signaling receptor activity
I6I45_RS24110	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I45_RS24115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I45_RS24120	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I45_RS24125	COG0142	geranyltranstransferase activity
I6I45_RS24130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I45_RS24135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I45_RS24140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I45_RS24145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I45_RS24150	COG3045	CreA protein
I6I45_RS24155	COG0386	Belongs to the glutathione peroxidase family
I6I45_RS24170	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6I45_RS24175	COG0492	ferredoxin-NADP+ reductase activity
I6I45_RS24190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I45_RS24195	COG0302	gtp cyclohydrolase
I6I45_RS24220	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I45_RS24235	COG0596	Alpha beta hydrolase
I6I45_RS24240	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS24255	COG2197	response regulator
I6I45_RS24260	COG3708	Transcriptional regulator
I6I45_RS24260	COG2207	Transcriptional regulator
I6I45_RS24270	COG3604	Transcriptional regulator
I6I45_RS24275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I45_RS24275	COG1017	nitric oxide dioxygenase activity
I6I45_RS24280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I45_RS24285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I45_RS24290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I45_RS24305	COG0109	protoheme IX farnesyltransferase activity
I6I45_RS24310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I45_RS24325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I45_RS24350	COG2814	Major facilitator Superfamily
I6I45_RS24355	COG1104	cysteine desulfurase activity
I6I45_RS24370	COG2161	toxin-antitoxin pair type II binding
I6I45_RS24390	COG4251	negative regulation of phosphorylation
I6I45_RS24430	COG1280	lysine exporter protein (LysE YggA)
I6I45_RS24460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I45_RS24465	COG0343	queuine tRNA-ribosyltransferase activity
I6I45_RS24470	COG1862	Preprotein translocase
I6I45_RS24485	COG3134	Outer membrane lipoprotein
I6I45_RS24500	COG1045	serine acetyltransferase
I6I45_RS24510	COG1104	cysteine desulfurase activity
I6I45_RS24520	COG0316	Belongs to the HesB IscA family
I6I45_RS24525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I45_RS24530	COG0443	Heat shock 70 kDa protein
I6I45_RS24535	COG0633	Ferredoxin
I6I45_RS24545	COG0105	UTP biosynthetic process
I6I45_RS24550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I45_RS24560	COG1426	Protein conserved in bacteria
I6I45_RS24565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I45_RS24570	COG0124	histidyl-tRNA synthetase
I6I45_RS24585	COG1160	GTP binding
I6I45_RS24590	COG0436	Aminotransferase
I6I45_RS24600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I45_RS24605	COG0739	heme binding
I6I45_RS24610	COG1570	exodeoxyribonuclease VII activity
I6I45_RS24615	COG0583	DNA-binding transcription factor activity
I6I45_RS24635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I45_RS24635	COG0519	Catalyzes the synthesis of GMP from XMP
I6I45_RS24645	COG2188	Transcriptional regulator
I6I45_RS24650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I45_RS24650	COG1263	PTS System
I6I45_RS24655	COG0366	Alpha amylase catalytic
I6I45_RS24660	COG4580	involved in the transport of maltose and maltodextrins
I6I45_RS24665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I45_RS24665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I45_RS24670	COG2190	(PTS) system
I6I45_RS24670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I45_RS24670	COG1263	PTS System
I6I45_RS24675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I45_RS24680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I45_RS24680	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I45_RS24685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I45_RS24700	COG1263	PTS System
I6I45_RS24700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I45_RS24700	COG2190	(PTS) system
I6I45_RS24705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I45_RS24705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I45_RS24710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I45_RS24715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I45_RS24720	COG2188	Transcriptional regulator
I6I45_RS24735	COG0494	nUDIX hydrolase
I6I45_RS24755	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I45_RS24760	COG0477	Major facilitator Superfamily
I6I45_RS24765	COG4536	flavin adenine dinucleotide binding
I6I45_RS24775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I45_RS24780	COG0228	four-way junction DNA binding
I6I45_RS24785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I45_RS24790	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I45_RS24795	COG0335	large ribosomal subunit rRNA binding
I6I45_RS24800	COG1607	acyl-coa hydrolase
I6I45_RS24805	COG3263	regulation of cellular component size
I6I45_RS24810	COG4974	Belongs to the 'phage' integrase family
I6I45_RS24835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I45_RS24870	COG2197	response regulator
I6I45_RS24880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I45_RS24915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I45_RS24925	COG0442	prolyl-tRNA aminoacylation
I6I45_RS24955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I45_RS24960	COG0459	protein refolding
I6I45_RS24970	COG1368	sulfuric ester hydrolase activity
I6I45_RS24995	COG3642	lipopolysaccharide core region biosynthetic process
I6I45_RS25025	COG0840	transmembrane signaling receptor activity
I6I45_RS25030	COG2832	Protein of unknown function (DUF454)
I6I45_RS25040	COG4771	TonB-dependent receptor
I6I45_RS25045	COG3712	iron ion homeostasis
I6I45_RS25080	COG2207	Transcriptional regulator
I6I45_RS25105	COG0477	Major facilitator Superfamily
I6I45_RS25115	COG4191	Histidine kinase
I6I45_RS25130	COG0469	pyruvate kinase activity
I6I45_RS25150	COG0714	Associated with various cellular activities
I6I45_RS25175	COG2925	Exonuclease
I6I45_RS25185	COG0788	formyltetrahydrofolate deformylase activity
I6I45_RS25200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I45_RS25200	COG0438	transferase activity, transferring glycosyl groups
I6I45_RS25210	COG0433	COG0433 Predicted ATPase
I6I45_RS25220	COG0653	protein targeting
I6I45_RS25225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I45_RS25240	COG2096	Adenosyltransferase
I6I45_RS25245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS25245	COG4191	Histidine kinase
I6I45_RS25255	COG1666	GTP binding
I6I45_RS25260	COG0668	transmembrane transport
I6I45_RS25275	COG2900	Belongs to the SlyX family
I6I45_RS25285	COG0783	Belongs to the Dps family
I6I45_RS25300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I45_RS25305	COG0217	transcriptional regulatory protein
I6I45_RS25310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I45_RS25315	COG0632	four-way junction helicase activity
I6I45_RS25320	COG2255	four-way junction helicase activity
I6I45_RS25325	COG0824	Thioesterase
I6I45_RS25345	COG0823	Involved in the tonB-independent uptake of proteins
I6I45_RS25350	COG2885	chlorophyll binding
I6I45_RS25355	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I45_RS25360	COG0602	queuosine metabolic process
I6I45_RS25370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I45_RS25420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I45_RS25430	COG1278	Cold shock
I6I45_RS25435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I45_RS25440	COG1760	l-serine dehydratase
I6I45_RS25445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I45_RS25445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I45_RS25450	COG0509	glycine decarboxylation via glycine cleavage system
I6I45_RS25495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I45_RS25500	COG0642	Histidine kinase
I6I45_RS25510	COG0745	RESPONSE REGULATOR receiver
I6I45_RS25515	COG2350	Protein conserved in bacteria
I6I45_RS25520	COG2917	probably involved in intracellular septation
I6I45_RS25525	COG0613	PHP domain protein
I6I45_RS25530	COG0009	L-threonylcarbamoyladenylate synthase
I6I45_RS25540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I45_RS25565	COG1113	amino acid transport
I6I45_RS25600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I45_RS25620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I45_RS25635	COG0583	DNA-binding transcription factor activity
I6I45_RS25640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I45_RS25655	COG1653	transport
I6I45_RS25660	COG1175	transmembrane transport
I6I45_RS25665	COG0395	ABC-type sugar transport system, permease component
I6I45_RS25670	COG3842	ATPase activity
I6I45_RS25680	COG0676	glucose-6-phosphate 1-epimerase activity
I6I45_RS25685	COG1737	Transcriptional regulator
I6I45_RS25700	COG0800	Aldolase
I6I45_RS25705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I45_RS25710	COG3530	Putative quorum-sensing-regulated virulence factor
I6I45_RS25720	COG2030	dehydratase
I6I45_RS25725	COG2267	carboxylic ester hydrolase activity
I6I45_RS25745	COG3237	CsbD-like
I6I45_RS25750	COG1295	ribonuclease BN
I6I45_RS25755	COG0242	peptide deformylase activity
I6I45_RS25780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I45_RS25795	COG2271	Major facilitator Superfamily
I6I45_RS25815	COG1609	Transcriptional regulator
I6I45_RS25820	COG3265	gluconokinase activity
I6I45_RS25830	COG0436	Aminotransferase
I6I45_RS25850	COG3795	YCII-related domain
I6I45_RS25860	COG4941	Belongs to the sigma-70 factor family
I6I45_RS25865	COG0583	DNA-binding transcription factor activity
I6I45_RS25875	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS25880	COG0583	DNA-binding transcription factor activity
I6I45_RS25890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I45_RS25900	COG1984	allophanate hydrolase subunit 2
I6I45_RS25915	COG0584	glycerophosphoryl diester phosphodiesterase
I6I45_RS25925	COG2329	Antibiotic biosynthesis monooxygenase
I6I45_RS25930	COG0504	CTP synthase activity
I6I45_RS25945	COG3706	GGDEF domain
I6I45_RS25965	COG0154	amidase activity
I6I45_RS25980	COG2814	Major facilitator Superfamily
I6I45_RS25995	COG0765	amino acid transport
I6I45_RS26000	COG0165	Argininosuccinate lyase
I6I45_RS26020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I45_RS26045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I45_RS26080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I45_RS26095	COG1012	belongs to the aldehyde dehydrogenase family
I6I45_RS26100	COG3724	N-succinylarginine dihydrolase activity
I6I45_RS26110	COG2988	succinylglutamate desuccinylase activity
I6I45_RS26115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I45_RS26120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I45_RS26125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I45_RS26130	COG0527	aspartate kinase activity
I6I45_RS26135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I45_RS26155	COG2239	Acts as a magnesium transporter
I6I45_RS26200	COG0477	Major facilitator Superfamily
I6I45_RS26205	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6I45_RS26225	COG0784	Response regulator, receiver
I6I45_RS26225	COG0835	chemotaxis
I6I45_RS26230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I45_RS26235	COG1815	bacterial-type flagellum-dependent cell motility
I6I45_RS26245	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I45_RS26265	COG0745	RESPONSE REGULATOR receiver
I6I45_RS26270	COG2205	protein histidine kinase activity
I6I45_RS26295	COG4977	sequence-specific DNA binding
I6I45_RS26295	COG1917	Cupin 2, conserved barrel domain protein
I6I45_RS26300	COG1301	dicarboxylic acid transport
I6I45_RS26305	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I45_RS26305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I45_RS26310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I45_RS26315	COG1530	ribonuclease E activity
I6I45_RS26325	COG0546	phosphoglycolate phosphatase activity
I6I45_RS26335	COG0424	maF-like protein
I6I45_RS26345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I45_RS26350	COG0416	fatty acid biosynthetic process
I6I45_RS26365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I45_RS26370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I45_RS26380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I45_RS26385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I45_RS26395	COG0084	hydrolase, TatD family'
I6I45_RS26405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I45_RS26420	COG2188	Transcriptional regulator
I6I45_RS26425	COG1397	ADP-ribosylglycohydrolase
I6I45_RS26465	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS26470	COG1879	ABC-type sugar transport system periplasmic component
I6I45_RS26475	COG1129	ABC transporter
I6I45_RS26480	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I45_RS26485	COG1414	Transcriptional regulator
I6I45_RS26490	COG1064	alcohol dehydrogenase
I6I45_RS26495	COG2207	Transcriptional regulator
I6I45_RS26525	COG2885	chlorophyll binding
I6I45_RS26530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I45_RS26560	COG2308	Evidence 4 Homologs of previously reported genes of
I6I45_RS26570	COG1305	Transglutaminase-like
I6I45_RS26580	COG0183	Belongs to the thiolase family
I6I45_RS26585	COG1024	Enoyl-CoA hydratase
I6I45_RS26585	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I45_RS26590	COG0519	Catalyzes the synthesis of GMP from XMP
I6I45_RS26590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I45_RS26595	COG0598	Magnesium transport protein CorA
I6I45_RS26655	COG5377	YqaJ viral recombinase family
I6I45_RS26680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I45_RS26705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I45_RS26710	COG1074	ATP-dependent DNA helicase activity
I6I45_RS26715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I45_RS26750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I45_RS26780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I45_RS26860	COG3011	Protein conserved in bacteria
I6I45_RS26890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I45_RS26895	COG1028	Short-chain dehydrogenase reductase Sdr
I6I45_RS26900	COG0583	DNA-binding transcription factor activity
I6I45_RS26910	COG1953	Uracil, thiamine, allantoin
I6I45_RS26920	COG0560	Phosphoserine phosphatase
I6I45_RS26940	COG0189	ligase activity
I6I45_RS26950	COG4067	protein conserved in archaea
I6I45_RS26950	COG0189	ligase activity
I6I45_RS26955	COG1802	Transcriptional regulator
I6I45_RS26965	COG0372	Belongs to the citrate synthase family
I6I45_RS26985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I45_RS26990	COG1045	serine acetyltransferase
I6I45_RS26995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I45_RS27010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I45_RS27015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I45_RS27030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I45_RS27055	COG2885	chlorophyll binding
I6I45_RS27055	COG3047	cAMP biosynthetic process
I6I45_RS27060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I45_RS27065	COG0243	molybdopterin cofactor binding
I6I45_RS27070	COG2146	nitrite reductase [NAD(P)H] activity
I6I45_RS27075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I45_RS27085	COG2223	nitrite transmembrane transporter activity
I6I45_RS27090	COG3707	response regulator
I6I45_RS27095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I45_RS27095	COG1116	anion transmembrane transporter activity
I6I45_RS27105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I45_RS27120	COG0167	dihydroorotate dehydrogenase activity
I6I45_RS27125	COG3130	regulation of translation
I6I45_RS27130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I45_RS27130	COG0116	Belongs to the methyltransferase superfamily
I6I45_RS27145	COG3171	Protein conserved in bacteria
I6I45_RS27150	COG3135	benzoate transporter
I6I45_RS27160	COG0402	S-adenosylhomocysteine deaminase activity
I6I45_RS27170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I45_RS27190	COG3115	cell septum assembly
I6I45_RS27195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I45_RS27280	COG0583	DNA-binding transcription factor activity
I6I45_RS27290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I45_RS27295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I45_RS27300	COG2130	NADP-dependent
I6I45_RS27305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I45_RS27315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I45_RS27320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I45_RS27355	COG0348	domain, Protein
I6I45_RS27360	COG2010	Cytochrome c
I6I45_RS27375	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I45_RS27380	COG2010	Cytochrome c
I6I45_RS27395	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I45_RS27405	COG0840	transmembrane signaling receptor activity
I6I45_RS27425	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I45_RS27430	COG1643	Atp-dependent helicase
I6I45_RS27440	COG1595	DNA-templated transcription, initiation
I6I45_RS27450	COG2188	Transcriptional regulator
I6I45_RS27460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I45_RS27465	COG1132	(ABC) transporter
I6I45_RS27475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I45_RS27490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I45_RS27500	COG3321	synthase
I6I45_RS27500	COG0604	alcohol dehydrogenase
I6I45_RS27505	COG4221	oxidoreductase activity
I6I45_RS27515	COG0668	transmembrane transport
I6I45_RS27520	COG0513	Belongs to the DEAD box helicase family
I6I45_RS27535	COG2132	Multicopper oxidase
I6I45_RS27570	COG2996	Protein conserved in bacteria
I6I45_RS27585	COG0583	DNA-binding transcription factor activity
I6I45_RS27595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I45_RS27620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I45_RS27625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I45_RS27630	COG3956	TIGRFAM MazG family protein
I6I45_RS27635	COG3122	Protein conserved in bacteria
I6I45_RS27645	COG2814	Major facilitator Superfamily
I6I45_RS27650	COG4264	IucA IucC family
I6I45_RS27665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I45_RS27670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I45_RS27680	COG0628	permease
I6I45_RS27685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I45_RS27690	COG0791	NLP P60 protein
I6I45_RS27695	COG0791	NLP P60 protein
I6I45_RS27710	COG1797	cobyrinic acid a,c-diamide synthase activity
I6I45_RS27715	COG0778	Nitroreductase
I6I45_RS27720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6I45_RS27730	COG1492	cobalamin metabolic process
I6I45_RS27740	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I45_RS27745	COG0406	alpha-ribazole phosphatase activity
I6I45_RS27750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6I45_RS27755	COG1846	Transcriptional regulator
I6I45_RS27800	COG2198	Histidine kinase
I6I45_RS27800	COG2205	protein histidine kinase activity
I6I45_RS27800	COG0784	Response regulator, receiver
I6I45_RS27805	COG2832	Protein of unknown function (DUF454)
I6I45_RS27815	COG0514	ATP-dependent DNA helicase (RecQ)
I6I45_RS27820	COG1846	Transcriptional regulator
I6I45_RS27825	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I45_RS27840	COG2207	Transcriptional regulator
I6I45_RS27855	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I45_RS27870	COG4787	bacterial-type flagellum-dependent cell motility
I6I45_RS27880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6I45_RS27885	COG1706	bacterial-type flagellum-dependent cell motility
I6I45_RS27895	COG1256	bacterial-type flagellum assembly
I6I45_RS27905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I45_RS27920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end