locus-tag class description C6Y56_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C6Y56_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C6Y56_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C6Y56_RS00025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C6Y56_RS00030 ENOG4105BZU Histidine kinase C6Y56_RS00040 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C6Y56_RS00045 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C6Y56_RS00050 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C6Y56_RS00055 ENOG4108R3E Dna-3-methyladenine glycosylase i C6Y56_RS00065 ENOG4105WAP TPR repeat-containing protein C6Y56_RS00070 ENOG4105C1A potassium transporter peripheral membrane C6Y56_RS00075 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C6Y56_RS00080 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C6Y56_RS00085 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C6Y56_RS00095 ENOG4105C79 DNA protecting protein DprA C6Y56_RS00100 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C6Y56_RS00105 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C6Y56_RS00110 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) C6Y56_RS00115 ENOG4105E2X shikimate dehydrogenase C6Y56_RS00130 ENOG4105CBG Sulfatase C6Y56_RS00155 ENOG4105D4T Citrate transporter C6Y56_RS00160 ENOG4105EE5 Membrane protein terC C6Y56_RS00165 ENOG4105EAM Na Pi-cotransporter C6Y56_RS00170 ENOG4107RAN Peptidase, M16 C6Y56_RS00185 ENOG4105DHJ ABC, transporter C6Y56_RS00205 ENOG4105CK2 sodium dicarboxylate symporter C6Y56_RS00210 ENOG4108ZGU inhibitor of vertebrate lysozyme C6Y56_RS00215 ENOG41067VU UPF0391 membrane protein C6Y56_RS00225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS00230 ENOG4105ES5 Histidine kinase C6Y56_RS00235 ENOG41066DG (EAL) domain protein C6Y56_RS00240 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase C6Y56_RS00255 ENOG4108Z33 Thiol disulfide Interchange Protein C6Y56_RS00260 ENOG4106RE7 Cytochrome C6Y56_RS00270 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C6Y56_RS00275 ENOG4105C2M dna polymerase I C6Y56_RS00290 ENOG4105NXV High-affinity zinc uptake system protein C6Y56_RS00295 ENOG4105MYN Zinc uptake regulation protein C6Y56_RS00300 ENOG4105FDK ABC transporter C6Y56_RS00305 ENOG4105FAV ABC, transporter C6Y56_RS00320 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS00325 ENOG4108UMI ABC transporter, permease C6Y56_RS00330 ENOG4105D01 (LipO)protein C6Y56_RS00340 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C6Y56_RS00365 ENOG4107QS1 Cytochrome C Oxidase, Subunit III C6Y56_RS00370 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) C6Y56_RS00375 ENOG4105BZ9 Cytochrome C oxidase, subunit I C6Y56_RS00390 ENOG4105CHH sulfate transporter C6Y56_RS00395 ENOG4107B2H carbonic anhydrase C6Y56_RS00425 ENOG4105DGW oligopeptidase A C6Y56_RS00430 ENOG4105VKU nucleicacid-binding protein C6Y56_RS00435 ENOG4105DGW oligopeptidase A C6Y56_RS00440 ENOG4108Z0R Transferase C6Y56_RS00445 ENOG4107XGZ Hydrolase C6Y56_RS00470 ENOG4108Z9K Osmotically inducible protein C6Y56_RS00475 ENOG4105DEN Luciferase family C6Y56_RS00485 ENOG4105WKW Pfam:DUF1458 C6Y56_RS00500 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C6Y56_RS00505 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C6Y56_RS00545 ENOG4105CYC Transferase C6Y56_RS00550 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C6Y56_RS00555 ENOG4105W8H transhydrogenase (subunit alpha C6Y56_RS00560 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C6Y56_RS00565 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS00570 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS00620 ENOG4108S3W Anti-feci sigma factor, fecr C6Y56_RS00625 ENOG4108SF5 RNA Polymerase C6Y56_RS00630 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS00655 ENOG4105DRR Transcriptional regulator, GntR family C6Y56_RS00665 ENOG4105BZU Histidine kinase C6Y56_RS00680 ENOG4105DFG type I secretion outer membrane protein C6Y56_RS00685 ENOG4108JJA ABC, transporter C6Y56_RS00695 ENOG4105E2B Taurine dioxygenase C6Y56_RS00710 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C6Y56_RS00720 ENOG4105C0R drug resistance transporter emrb qaca subfamily C6Y56_RS00730 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C6Y56_RS00795 ENOG4107QX8 SPFH domain, Band 7 family protein C6Y56_RS00825 ENOG4105DSW Fusaric acid resistance protein C6Y56_RS00835 ENOG4105Y49 secretion protein, HlyD family C6Y56_RS00840 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C6Y56_RS00850 ENOG4106J39 exported protein C6Y56_RS00855 ENOG4108TUY outer membrane protein PgaA C6Y56_RS00860 ENOG4107BJW polysaccharide deacetylase C6Y56_RS00865 ENOG4105CND Glycosyl transferase, family 2 C6Y56_RS00885 ENOG4105CP2 von willebrand factor, type a C6Y56_RS00890 ENOG4108WQI RNA Polymerase C6Y56_RS00910 ENOG4105C26 Dehydrogenase C6Y56_RS00915 ENOG4108JPW Aminotransferase C6Y56_RS00935 ENOG4105BZU Histidine kinase C6Y56_RS00945 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C6Y56_RS00950 ENOG4108I5D sulfate abc transporter C6Y56_RS00955 ENOG4105ECW sulfate abc transporter C6Y56_RS00960 ENOG4108IJ6 ABC transporter C6Y56_RS01000 ENOG4108ZX5 transcriptional regulator C6Y56_RS01010 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) C6Y56_RS01020 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C6Y56_RS01025 ENOG4107Z6I Thiamine biosynthesis protein C6Y56_RS01050 ENOG4107ZSV Receptor C6Y56_RS01060 ENOG4105WQ5 TonB family C6Y56_RS01070 ENOG4105SG9 biopolymer transport protein, ExbD C6Y56_RS01080 ENOG4108JU7 Transcriptional regulator C6Y56_RS01085 ENOG4105D01 (LipO)protein C6Y56_RS01095 ENOG4105DRP amino acid AbC transporter C6Y56_RS01100 ENOG4105E5Q amino acid AbC transporter C6Y56_RS01105 ENOG4105CDA abc transporter atp-binding protein C6Y56_RS01110 ENOG4105CT1 (ABC) transporter C6Y56_RS01115 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C6Y56_RS01130 ENOG4105BZS acriflavin resistance protein C6Y56_RS01145 ENOG4108UMI ABC transporter, permease C6Y56_RS01150 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS01155 ENOG4105D01 (LipO)protein C6Y56_RS01165 ENOG4107T8P acyl-Coa dehydrogenase C6Y56_RS01170 ENOG4107T8P acyl-Coa dehydrogenase C6Y56_RS01180 ENOG4105CDA abc transporter atp-binding protein C6Y56_RS01185 ENOG4105E5Q amino acid AbC transporter C6Y56_RS01190 ENOG4105EAB amino acid AbC transporter C6Y56_RS01195 ENOG4105K6H D-cysteine desulfhydrase C6Y56_RS01200 ENOG4105D7W serine acetyltransferase C6Y56_RS01205 ENOG4105C94 Transporter C6Y56_RS01230 ENOG4105CPC Aldo Keto reductase C6Y56_RS01240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C6Y56_RS01245 ENOG4108IY8 ABC, transporter C6Y56_RS01250 ENOG4106FTQ Taurine ABC transporter, periplasmic C6Y56_RS01255 ENOG4105D9M gamma-glutamylcysteine synthetase C6Y56_RS01265 ENOG4105BZM domain protein C6Y56_RS01275 ENOG4105E0F Histidine kinase C6Y56_RS01280 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C6Y56_RS01285 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C6Y56_RS01290 ENOG4105BZU Histidine kinase C6Y56_RS01295 ENOG4105VEJ Heat shock protein C6Y56_RS01305 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C6Y56_RS01310 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C6Y56_RS01345 ENOG4105C9U ATP-dependent DNA helicase RecQ C6Y56_RS01350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C6Y56_RS01365 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit C6Y56_RS01370 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C6Y56_RS01375 ENOG4105C5Q Transcriptional regulator C6Y56_RS01380 ENOG4109066 lysm domain bon superfamily protein C6Y56_RS01385 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 C6Y56_RS01390 ENOG4107RK2 ADP-ribose diphosphatase NudE C6Y56_RS01395 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C6Y56_RS01405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS01410 ENOG4105CQZ Histidine kinase C6Y56_RS01415 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C6Y56_RS01425 ENOG4105DWY Agmatine deiminase C6Y56_RS01445 ENOG4105J5J Outer membrane porin C6Y56_RS01455 ENOG4108R6G acetyltransferase C6Y56_RS01485 ENOG4105VSH 4-oxalocrotonate tautomerase C6Y56_RS01495 ENOG4105CHR reductase C6Y56_RS01530 ENOG4105E89 ABC transporter C6Y56_RS01535 ENOG4108JEH abc transporter atp-binding protein C6Y56_RS01570 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) C6Y56_RS01575 ENOG4105CEN a g-specific adenine glycosylase C6Y56_RS01590 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C6Y56_RS01595 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C6Y56_RS01605 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C6Y56_RS01610 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C6Y56_RS01625 ENOG4105PXI polysaccharide deacetylase C6Y56_RS01630 ENOG4105CN1 protease C6Y56_RS01635 ENOG41063SB peptidase C6Y56_RS01640 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C6Y56_RS01650 ENOG4105VW4 glutaredoxin 3 C6Y56_RS01655 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) C6Y56_RS01660 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C6Y56_RS01670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS01675 ENOG4105CUX Signal transduction histidine kinase C6Y56_RS01700 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C6Y56_RS01705 ENOG4105CI3 gtp-binding protein typa C6Y56_RS01715 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) C6Y56_RS01730 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 C6Y56_RS01740 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS01755 ENOG4105QNF Outer membrane lipoprotein C6Y56_RS01760 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C6Y56_RS01765 ENOG4105CZE histidine utilization repressor C6Y56_RS01770 ENOG41090B9 response to stress C6Y56_RS01775 ENOG4105CGP Urocanate hydratase C6Y56_RS01780 ENOG4105ETS cytosine purines uracil thiamine allantoin C6Y56_RS01790 ENOG4108HQS Glycine betaine C6Y56_RS01795 ENOG4108IJ7 Glycine betaine C6Y56_RS01800 ENOG4105C84 Histidine ammonia-lyase C6Y56_RS01805 ENOG4105C84 Histidine ammonia-lyase C6Y56_RS01810 ENOG4105CI2 imidazolone-5-propionate hydrolase C6Y56_RS01835 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C6Y56_RS01840 ENOG4105DJ9 glucan biosynthesis protein C6Y56_RS01845 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) C6Y56_RS01850 ENOG4106PMH Extracellular solute-binding protein family 3 C6Y56_RS01855 ENOG4105EAD ABC transporter C6Y56_RS01865 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS01880 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C6Y56_RS01885 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C6Y56_RS01890 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase C6Y56_RS01895 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C6Y56_RS01900 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C6Y56_RS01910 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C6Y56_RS01955 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C6Y56_RS01960 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C6Y56_RS01970 ENOG4105C75 arginyL-tRNA synthetase C6Y56_RS01975 ENOG4105C25 Primosomal protein n' C6Y56_RS01980 ENOG4105VFB Binds the 23S rRNA (By similarity) C6Y56_RS01990 ENOG4105C6K Malic enzyme C6Y56_RS01995 ENOG4108JQC penicillin-binding protein 1A C6Y56_RS02020 ENOG4105E4G Type IV pilus C6Y56_RS02025 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C6Y56_RS02030 ENOG4105D49 3-dehydroquinate synthase C6Y56_RS02040 ENOG4105CBC glutamate synthase C6Y56_RS02045 ENOG4105BZ8 glutamate synthase C6Y56_RS02050 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C6Y56_RS02055 ENOG4105D94 Major Facilitator Superfamily C6Y56_RS02060 ENOG4106NZI LysR family Transcriptional regulator C6Y56_RS02075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C6Y56_RS02080 ENOG4105C2D reductase C6Y56_RS02090 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C6Y56_RS02130 ENOG4105C84 Histidine ammonia-lyase C6Y56_RS02140 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) C6Y56_RS02145 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C6Y56_RS02160 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C6Y56_RS02175 ENOG4107SKI cobyrinic Acid a,c-diamide synthase C6Y56_RS02180 ENOG4105K63 Thioredoxin C6Y56_RS02185 ENOG4105CNG UPF0061 protein C6Y56_RS02190 ENOG4105EGS Mechanosensitive ion channel C6Y56_RS02195 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) C6Y56_RS02220 ENOG41069D7 Methyl-accepting chemotaxis C6Y56_RS02225 ENOG4105CSU acyl-Coa dehydrogenase C6Y56_RS02230 ENOG4105C26 Dehydrogenase C6Y56_RS02235 ENOG4105CK7 Sodium proline symporter C6Y56_RS02240 ENOG4105CS6 Rhs element vgr protein C6Y56_RS02275 ENOG4105D6S protein involved in catabolism of external DNA C6Y56_RS02280 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C6Y56_RS02285 ENOG4105BZU Histidine kinase C6Y56_RS02295 ENOG4107QSN dihydrolipoamide acetyltransferase C6Y56_RS02300 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C6Y56_RS02305 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C6Y56_RS02310 ENOG4105XA0 heptosyltransferase ii C6Y56_RS02315 ENOG4105D16 lipopolysaccharide heptosyltransferase i C6Y56_RS02320 ENOG4107RJ7 Glycosyl transferase (Group 1 C6Y56_RS02325 ENOG4107543 (lipo)polysaccharide C6Y56_RS02360 ENOG4105CPK Glycosyl transferase (Group 1 C6Y56_RS02375 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C6Y56_RS02380 ENOG4108SHN Glycosyl transferase, family 2 C6Y56_RS02395 ENOG4105BZ1 (ABC) transporter C6Y56_RS02405 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C6Y56_RS02415 ENOG4105CPC Aldo Keto reductase C6Y56_RS02420 ENOG41087SS fad dependent oxidoreductase C6Y56_RS02425 ENOG410814C multidrug resistance protein C6Y56_RS02435 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C6Y56_RS02440 ENOG4105DFG type I secretion outer membrane protein C6Y56_RS02445 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C6Y56_RS02460 ENOG41087AY ADP-Ribose pyrophosphatase C6Y56_RS02470 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C6Y56_RS02475 ENOG4105IPS esterase C6Y56_RS02480 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C6Y56_RS02490 ENOG4108WIW Aspartyl protease C6Y56_RS02495 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C6Y56_RS02510 ENOG4105EAC phosphoserine phosphatase C6Y56_RS02520 ENOG41077ZI C6Y56_RS02525 ENOG4105DJ4 phosphatidylserine decarboxylase C6Y56_RS02530 ENOG4105KHC sulfurtransferase C6Y56_RS02540 ENOG4107RD7 Flagellar Motor Protein, MotA C6Y56_RS02545 ENOG4105ER2 Ompa motb domain protein C6Y56_RS02550 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C6Y56_RS02555 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C6Y56_RS02560 ENOG4105EN6 Membrane C6Y56_RS02585 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C6Y56_RS02590 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C6Y56_RS02595 ENOG4105K8N protein family UPF0079, ATPase C6Y56_RS02600 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C6Y56_RS02605 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C6Y56_RS02610 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C6Y56_RS02615 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C6Y56_RS02620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C6Y56_RS02625 ENOG4107QJR hflk protein C6Y56_RS02630 ENOG4105EPW hflc protein C6Y56_RS02635 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C6Y56_RS02640 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C6Y56_RS02645 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS02650 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component C6Y56_RS02655 ENOG4107QKW extracellular solute-binding protein family 1 C6Y56_RS02670 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C6Y56_RS02675 ENOG4105C2N RNA methyltransferase TrmH family group 3 C6Y56_RS02680 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C6Y56_RS02695 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C6Y56_RS02700 ENOG4105CDU Replicative dna helicase C6Y56_RS02710 ENOG4105CCT upf0313 protein C6Y56_RS02720 ENOG4105NPQ Pfam:DUF403 C6Y56_RS02735 ENOG4108URH decarboxylase C6Y56_RS02745 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C6Y56_RS02750 ENOG4107RH7 Nicotinate phosphoribosyltransferase C6Y56_RS02755 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS02760 ENOG4105C26 Dehydrogenase C6Y56_RS02765 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS02775 ENOG4105C32 Amino acid ABC transporter (Permease) C6Y56_RS02780 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C6Y56_RS02785 ENOG4105C0Z ABC transporter C6Y56_RS02790 ENOG4108IV0 ABC, transporter C6Y56_RS02795 ENOG4105EMU Dehydrogenase C6Y56_RS02820 ENOG4105IY8 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) C6Y56_RS02825 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) C6Y56_RS02830 ENOG4105EJ2 Transcriptional regulator C6Y56_RS02840 ENOG41066T0 asmA family C6Y56_RS02850 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS02870 ENOG4108IPJ Membrane C6Y56_RS02880 ENOG4105VIF phosphate starvation-inducible protein C6Y56_RS02890 ENOG4105R8A Heat shock protein C6Y56_RS02895 ENOG4105DVC DnaJ domain protein C6Y56_RS02900 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) C6Y56_RS02905 ENOG4105BZU Histidine kinase C6Y56_RS02915 ENOG4105CQM Urea amidohydrolase subunit alpha C6Y56_RS02920 ENOG4105KI2 Urea amidohydrolase subunit beta C6Y56_RS02935 ENOG4108YZ9 Urea amidohydrolase subunit gamma C6Y56_RS02940 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) C6Y56_RS02945 ENOG4108IV0 ABC, transporter C6Y56_RS02950 ENOG4105C0Z ABC transporter C6Y56_RS02960 ENOG4105C32 Amino acid ABC transporter (Permease) C6Y56_RS02965 ENOG41083Z3 extracellular ligand-binding receptor C6Y56_RS02970 ENOG4105EHG Permease protein C6Y56_RS02980 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS02985 ENOG4105E0K tonB-dependent siderophore receptor C6Y56_RS03015 ENOG4105YES addiction module antidote protein C6Y56_RS03020 ENOG4105VUH addiction module killer protein C6Y56_RS03030 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) C6Y56_RS03035 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase C6Y56_RS03040 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C6Y56_RS03045 ENOG41081F0 Precorrin-8x methylmutase C6Y56_RS03050 ENOG4105DVK Precorrin-2 c20-methyltransferase C6Y56_RS03060 ENOG41081FY multiple antibiotic resistance (MarC)-related C6Y56_RS03065 ENOG4105BZU Histidine kinase C6Y56_RS03070 ENOG4105C12 Phosphoribosylglycinamide synthetase C6Y56_RS03075 ENOG4105DC1 bifunctional purine biosynthesis protein purh C6Y56_RS03080 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) C6Y56_RS03085 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C6Y56_RS03095 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C6Y56_RS03100 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C6Y56_RS03105 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C6Y56_RS03110 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C6Y56_RS03115 ENOG4108W2P Methyl-accepting chemotaxis C6Y56_RS03130 ENOG4105PTV Nudix Hydrolase C6Y56_RS03135 ENOG4108ZJT translation initiation factor, Sui1 C6Y56_RS03140 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) C6Y56_RS03155 ENOG4107R73 Mate efflux family protein C6Y56_RS03170 ENOG4106371 Methyltransferase C6Y56_RS03280 ENOG4105CHR reductase C6Y56_RS03285 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS03290 ENOG4108KQ5 Integrase catalytic subunit C6Y56_RS03295 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS03310 ENOG4108Z6Z Transcriptional regulator C6Y56_RS03315 ENOG4105C59 p-type ATPase C6Y56_RS03325 ENOG4105C59 p-type ATPase C6Y56_RS03330 ENOG4105E5M Multidrug resistance protein D C6Y56_RS03340 ENOG4105CIS alcohol dehydrogenase C6Y56_RS03350 ENOG4105CR8 Transcriptional regulator C6Y56_RS03360 ENOG41079KZ Major Facilitator Superfamily C6Y56_RS03365 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C6Y56_RS03385 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C6Y56_RS03410 ENOG4105UIB (ABC) transporter C6Y56_RS03415 ENOG4105C2J ABC transporter C6Y56_RS03425 ENOG4108R86 Transcriptional regulator C6Y56_RS03430 ENOG4105EVZ LysR family transcriptional regulator C6Y56_RS03440 ENOG4105C26 Dehydrogenase C6Y56_RS03470 ENOG4105DSY exodeoxyribonuclease V, gamma C6Y56_RS03475 ENOG4107QKA exodeoxyribonuclease V beta C6Y56_RS03480 ENOG4107QYX exodeoxyribonuclease v alpha C6Y56_RS03490 ENOG4108KHX Diguanylate cyclase C6Y56_RS03495 ENOG41090EK ompa motb domain protein C6Y56_RS03505 ENOG4105C26 Dehydrogenase C6Y56_RS03510 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C6Y56_RS03535 ENOG4105C1B dTDP-glucose 4-6-dehydratase C6Y56_RS03540 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C6Y56_RS03550 ENOG4106KE4 Dehydrogenase C6Y56_RS03560 ENOG4105ENT Efflux transporter rnd family, mfp subunit C6Y56_RS03565 ENOG4105BZS acriflavin resistance protein C6Y56_RS03575 ENOG4105YVS arsR family transcriptional regulator C6Y56_RS03580 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C6Y56_RS03590 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) C6Y56_RS03595 ENOG4108W5M transcriptional regulator C6Y56_RS03610 ENOG4105NF4 modulator of drug activity C6Y56_RS03615 ENOG4105HEI LysR family (Transcriptional regulator C6Y56_RS03655 ENOG4108KQ5 Integrase catalytic subunit C6Y56_RS03660 ENOG4108ZX5 transcriptional regulator C6Y56_RS03670 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C6Y56_RS03675 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C6Y56_RS03690 ENOG4105D25 secreted protein C6Y56_RS03695 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS03710 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C6Y56_RS03715 ENOG4105D9U N-acetyltransferase C6Y56_RS03785 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C6Y56_RS03795 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C6Y56_RS03800 ENOG4105DAA L-lactate C6Y56_RS03810 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C6Y56_RS03815 ENOG4105C8J )-transporter C6Y56_RS03820 ENOG4108Z1B Cyclase dehydrase C6Y56_RS03825 ENOG4105VDB UPF0125 protein C6Y56_RS03830 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C6Y56_RS03835 ENOG41090R7 Ferric uptake C6Y56_RS03840 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C6Y56_RS03845 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C6Y56_RS03850 ENOG4105CFG Acts as a chaperone (By similarity) C6Y56_RS03855 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C6Y56_RS03860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C6Y56_RS03865 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C6Y56_RS03870 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C6Y56_RS03875 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C6Y56_RS03885 ENOG4105HBR Rna-binding protein C6Y56_RS03890 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) C6Y56_RS03895 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C6Y56_RS03900 ENOG4105EEI dihydropteroate synthase C6Y56_RS03905 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C6Y56_RS03910 ENOG4105CP7 Triose-phosphate isomerase C6Y56_RS03915 ENOG4105NTZ Preprotein translocase subunit SecG C6Y56_RS03935 ENOG4105CHV Transcription elongation factor NusA C6Y56_RS03945 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C6Y56_RS03950 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C6Y56_RS03955 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C6Y56_RS03960 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C6Y56_RS03980 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C6Y56_RS04000 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS04010 ENOG4105EYA deoxyribonuclease C6Y56_RS04015 ENOG4107B7Y DNA-binding transcriptional regulator FruR C6Y56_RS04020 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C6Y56_RS04025 ENOG4105DE4 1-phosphofructokinase C6Y56_RS04030 ENOG4105DM4 PTS System C6Y56_RS04040 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C6Y56_RS04050 ENOG4107E2E PKHD-type hydroxylase C6Y56_RS04070 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C6Y56_RS04075 ENOG4108IJ8 ABC transporter C6Y56_RS04080 ENOG4105E90 ABC transporter C6Y56_RS04085 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system C6Y56_RS04090 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component C6Y56_RS04095 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) C6Y56_RS04120 ENOG4108JQ7 (ABC) transporter C6Y56_RS04125 ENOG4105C3U ABC transporter C6Y56_RS04130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C6Y56_RS04135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C6Y56_RS04140 ENOG4105DEF Extracellular solute-binding protein, family 5 C6Y56_RS04145 ENOG4105J5J Outer membrane porin C6Y56_RS04150 ENOG4105DEF Extracellular solute-binding protein, family 5 C6Y56_RS04155 ENOG4105DEF Extracellular solute-binding protein, family 5 C6Y56_RS04160 ENOG4105DEF Extracellular solute-binding protein, family 5 C6Y56_RS04175 ENOG4105TX3 Histidine kinase C6Y56_RS04185 ENOG4105CQ0 ABC transporter C6Y56_RS04215 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase C6Y56_RS04225 ENOG4105DJB Major Facilitator Superfamily C6Y56_RS04230 ENOG4105CTX dehydratase C6Y56_RS04240 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C6Y56_RS04255 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C6Y56_RS04260 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C6Y56_RS04265 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C6Y56_RS04275 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C6Y56_RS04280 ENOG4105VQ7 Rod shape-determining protein MreD C6Y56_RS04285 ENOG4108Z03 MAF-like protein C6Y56_RS04290 ENOG4105C03 ribonuclease C6Y56_RS04305 ENOG4105D1U peptidase U62 modulator of DNA gyrase C6Y56_RS04310 ENOG4105N42 UPF0307 protein C6Y56_RS04315 ENOG4105CMS peptidase U62, modulator of DNA gyrase C6Y56_RS04325 ENOG4105C9Q fumarate hydratase class II C6Y56_RS04335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C6Y56_RS04345 ENOG41080Z8 PHOSPHOCARRIER protein C6Y56_RS04350 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C6Y56_RS04355 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN C6Y56_RS04360 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA C6Y56_RS04365 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C6Y56_RS04370 ENOG4108IUZ ABC transporter C6Y56_RS04375 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA C6Y56_RS04390 ENOG4105C2X Arabinose 5-phosphate isomerase C6Y56_RS04395 ENOG4105DHJ ABC, transporter C6Y56_RS04400 ENOG4105CY3 ABC transporter, permease C6Y56_RS04405 ENOG4107PE3 Mammalian cell entry related domain protein C6Y56_RS04420 ENOG4105VFK BolA family C6Y56_RS04425 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C6Y56_RS04430 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C6Y56_RS04435 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C6Y56_RS04440 ENOG4105CIH Imidazole acetol-phosphate transaminase C6Y56_RS04450 ENOG4105C0H protease C6Y56_RS04455 ENOG4107QNR UPF0135 protein C6Y56_RS04460 ENOG4105C11 sulfate adenylyltransferase), subunit 2 C6Y56_RS04465 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) C6Y56_RS04470 ENOG4106HNH Acyl-transferase C6Y56_RS04475 ENOG4105C6K Malic enzyme C6Y56_RS04485 ENOG4108YZY peptidylprolyl cis-trans isomerase C6Y56_RS04490 ENOG4108V06 Glutathione peroxidase C6Y56_RS04505 ENOG4105EXN Sulfate transport protein CysZ C6Y56_RS04510 ENOG4105C3M thioredoxin reductase C6Y56_RS04525 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase C6Y56_RS04530 ENOG4105EUJ GTP cyclohydrolase i C6Y56_RS04535 ENOG410642E Short chain dehydrogenase C6Y56_RS04545 ENOG4108XDN Transcriptional regulator C6Y56_RS04555 ENOG4105BZU Histidine kinase C6Y56_RS04560 ENOG4105QDK Flavodoxin C6Y56_RS04565 ENOG4105C5Q Transcriptional regulator C6Y56_RS04570 ENOG4105VAW lrga family C6Y56_RS04575 ENOG41067MG lrgb family C6Y56_RS04580 ENOG4105MP9 class II Aldolase C6Y56_RS04590 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr C6Y56_RS04605 ENOG4105D25 secreted protein C6Y56_RS04610 ENOG4105WH1 Two component transcriptional regulator luxr family C6Y56_RS04625 ENOG4105F1J Homogentisate 1,2-dioxygenase C6Y56_RS04630 ENOG4105ERH Fumarylacetoacetate hydrolase C6Y56_RS04635 ENOG4108RXX maleylacetoacetate isomerase C6Y56_RS04640 ENOG4105D2S major facilitator superfamily C6Y56_RS04645 ENOG41063JG Transcriptional regulator C6Y56_RS04650 ENOG4107RDP Dehydrogenase C6Y56_RS04670 ENOG4105C44 Serine transporter C6Y56_RS04675 ENOG4105EJQ L-serine dehydratase C6Y56_RS04680 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS04690 ENOG4105GAV receptor C6Y56_RS04695 ENOG4108S3W Anti-feci sigma factor, fecr C6Y56_RS04700 ENOG4108SF5 RNA Polymerase C6Y56_RS04745 ENOG4105C5I Dehydrogenase C6Y56_RS04755 ENOG4105CR8 Transcriptional regulator C6Y56_RS04775 ENOG4105Y49 secretion protein, HlyD family C6Y56_RS04785 ENOG4105C0R drug resistance transporter emrb qaca subfamily C6Y56_RS04790 ENOG4105JQN Transcriptional regulator C6Y56_RS04795 ENOG4105E1F short-chain dehydrogenase reductase C6Y56_RS04810 ENOG4105CJT Mannose-1-phosphate guanylyltransferase C6Y56_RS04815 ENOG4105ZJ4 Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate is important for the architecture of biofilms and increases C6Y56_RS04820 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate C6Y56_RS04825 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C6Y56_RS04830 ENOG4105FN4 Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond (By similarity) C6Y56_RS04835 ENOG4105JHR Alginate biosynthesis protein AlgX C6Y56_RS04840 ENOG4108C0K Bifunctional protein that converts poly(beta-D- mannuronate) to alpha-L-guluronate and that is also part of a periplasmic protein complex that serves as a scaffold that leads the newly formed alginate polymer through the periplasmic space to the outer membrane secretin AlgE C6Y56_RS04845 ENOG4105Y9T outer membrane protein AlgE C6Y56_RS04850 ENOG4105XJP alginate biosynthesis protein C6Y56_RS04855 ENOG4108UIA Alginate biosynthesis protein Alg44 C6Y56_RS04860 ENOG4105KZJ alginate biosynthesis protein Alg8 C6Y56_RS04865 ENOG4105C6Y Udp-glucose 6-dehydrogenase C6Y56_RS04870 ENOG4105D1Q UPF0246 protein C6Y56_RS04880 ENOG4108IAB Phoh family C6Y56_RS04885 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C6Y56_RS04890 ENOG4105M00 molybdopterin converting factor, subunit 1 C6Y56_RS04895 ENOG4108ZAF Molybdopterin C6Y56_RS04900 ENOG4105E89 ABC transporter C6Y56_RS04905 ENOG4108SGR YheO domain-containing protein C6Y56_RS04910 ENOG4105FC8 fad dependent oxidoreductase C6Y56_RS04920 ENOG4105C1J atp-dependent rna helicase C6Y56_RS04925 ENOG4106CJB Phospholipase Carboxylesterase C6Y56_RS04935 ENOG4105EZ7 amino acid ABC transporter C6Y56_RS04940 ENOG4105DRP amino acid AbC transporter C6Y56_RS04945 ENOG4105CDA abc transporter atp-binding protein C6Y56_RS04950 ENOG4105JXH GntR family transcriptional regulator C6Y56_RS04955 ENOG4105DJ2 Major Facilitator Superfamily C6Y56_RS04965 ENOG41082IR Excinuclease ABC C subunit domain protein C6Y56_RS04980 ENOG4106V8H Nucleoid-associated protein C6Y56_RS04990 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) C6Y56_RS04995 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C6Y56_RS05005 ENOG4105MYG DNA polymerase iii, chi subunit C6Y56_RS05010 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C6Y56_RS05015 ENOG4108M8S permease YjgP YjgQ family protein C6Y56_RS05020 ENOG4108K5H permease YjgP YjgQ family protein C6Y56_RS05025 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C6Y56_RS05030 ENOG4105C3F Signal peptidase i C6Y56_RS05035 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C6Y56_RS05040 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C6Y56_RS05045 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) C6Y56_RS05050 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C6Y56_RS05055 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C6Y56_RS05060 ENOG4108ETH Formylglycinamide ribotide synthetase C6Y56_RS05070 ENOG4105CI1 PTS System C6Y56_RS05075 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C6Y56_RS05080 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C6Y56_RS05085 ENOG4105CE4 GlcNAc 6-P deacetylase C6Y56_RS05090 ENOG4105FDP GntR family transcriptional regulator C6Y56_RS05105 ENOG4105P8F nudix hydrolase C6Y56_RS05110 ENOG4108Z0R Transferase C6Y56_RS05125 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C6Y56_RS05130 ENOG4105CSH Transporter C6Y56_RS05135 ENOG4108JU6 CBS domain protein C6Y56_RS05145 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY C6Y56_RS05150 ENOG4105K5M 30s ribosomal protein S16 C6Y56_RS05155 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C6Y56_RS05160 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C6Y56_RS05165 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C6Y56_RS05175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C6Y56_RS05180 ENOG4105T95 Thiol disulfide interChange protein C6Y56_RS05185 ENOG4105D6E homoserine dehydrogenase C6Y56_RS05190 ENOG4105D98 threonine synthase C6Y56_RS05195 ENOG4105BZU Histidine kinase C6Y56_RS05215 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C6Y56_RS05220 ENOG4108VWS Yaeq family C6Y56_RS05225 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C6Y56_RS05230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS05240 ENOG4105DJ9 glucan biosynthesis protein C6Y56_RS05275 ENOG4105C26 Dehydrogenase C6Y56_RS05280 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component C6Y56_RS05285 ENOG4105D81 ABC transporter, permease C6Y56_RS05290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS05295 ENOG4107TYH extracellular solute-binding protein family 1 C6Y56_RS05305 ENOG4107RSM transcriptional regulator C6Y56_RS05325 ENOG4108KTQ Methyltransferase C6Y56_RS05335 ENOG4105CBS Chea signal transduction histidine kinase C6Y56_RS05340 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C6Y56_RS05355 ENOG4105CRK lysyL-tRNA synthetase C6Y56_RS05375 ENOG4107XM9 (LipO)protein C6Y56_RS05400 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C6Y56_RS05405 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C6Y56_RS05410 ENOG41072GX Peptidase M22 Glycoprotease C6Y56_RS05420 ENOG41081XQ Conserved Protein C6Y56_RS05435 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) C6Y56_RS05445 ENOG4105DJY efflux transporter, rnd family, mfp subunit C6Y56_RS05475 ENOG4105E55 glycerol-3-phosphate acyltransferase C6Y56_RS05480 ENOG4105VEQ Cold shock protein C6Y56_RS05490 ENOG4105DHI Methyltransferase C6Y56_RS05495 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C6Y56_RS05500 ENOG4107QJZ Glycosyl transferase, family 2 C6Y56_RS05505 ENOG4105CUZ uba thif-type nad fad binding protein C6Y56_RS05510 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) C6Y56_RS05515 ENOG4105C9B Cysteine desulfurase C6Y56_RS05520 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) C6Y56_RS05525 ENOG4105KUZ arsenate reductase C6Y56_RS05530 ENOG4105EEQ Na H antiporter C6Y56_RS05545 ENOG4105CHM Aminotransferase C6Y56_RS05550 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) C6Y56_RS05555 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C6Y56_RS05560 ENOG4105CE9 30S ribosomal protein S2 C6Y56_RS05565 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C6Y56_RS05570 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C6Y56_RS05575 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C6Y56_RS05580 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C6Y56_RS05585 ENOG4105KNE Phosphatidate cytidylyltransferase C6Y56_RS05590 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C6Y56_RS05595 ENOG4105DZP Membrane-associated zinc metalloprotease C6Y56_RS05605 ENOG4105X4K outer membrane chaperone skp C6Y56_RS05610 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C6Y56_RS05615 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C6Y56_RS05620 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C6Y56_RS05625 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C6Y56_RS05630 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C6Y56_RS05635 ENOG4105C0B DNA polymerase III (alpha subunit) C6Y56_RS05640 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C6Y56_RS05645 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C6Y56_RS05650 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C6Y56_RS05655 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C6Y56_RS05660 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C6Y56_RS05665 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C6Y56_RS05670 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C6Y56_RS05675 ENOG4105EXG Transcriptional regulator C6Y56_RS05685 ENOG4105C4W S-formylglutathione hydrolase C6Y56_RS05690 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C6Y56_RS05695 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) C6Y56_RS05700 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C6Y56_RS05705 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C6Y56_RS05710 ENOG4108K5P (LipO)protein C6Y56_RS05715 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C6Y56_RS05720 ENOG4108Z4U Ferredoxin C6Y56_RS05725 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C6Y56_RS05730 ENOG4108XTP Transcriptional regulator C6Y56_RS05835 ENOG4105TKZ Tail Sheath C6Y56_RS05870 ENOG4105WR6 Phage protein, GP46 C6Y56_RS05925 ENOG4105NVB glycoside hydrolase, family 19 C6Y56_RS05935 ENOG4107TH8 cina domain protein C6Y56_RS05940 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C6Y56_RS05945 ENOG4105Y3E Modulates RecA activity (By similarity) C6Y56_RS05965 ENOG4106IUH DTW domain containing protein C6Y56_RS05975 ENOG41080IJ Diacylglycerol kinase C6Y56_RS05980 ENOG4105DUM transcriptional regulator, lysR family C6Y56_RS05985 ENOG4105DP0 ferredoxin-NADP reductase C6Y56_RS05990 ENOG4108R96 Methyltransferase, YaeB family C6Y56_RS05995 ENOG4105CHR reductase C6Y56_RS06000 ENOG4108W15 Protein of unknown function (DUF1456) C6Y56_RS06010 ENOG4105K5X acetyltransferase C6Y56_RS06015 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) C6Y56_RS06020 ENOG4105DFH Transport of potassium into the cell (By similarity) C6Y56_RS06055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C6Y56_RS06065 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C6Y56_RS06070 ENOG4105EYM Major Facilitator superfamily C6Y56_RS06090 ENOG4105DHP deoxycytidine triphosphate deaminase C6Y56_RS06105 ENOG4107QRT dEAD DEAH box helicase C6Y56_RS06110 ENOG4108JEH abc transporter atp-binding protein C6Y56_RS06120 ENOG4106YG3 ABC transporter C6Y56_RS06125 ENOG4105DSP amino acid AbC transporter C6Y56_RS06130 ENOG4105E89 ABC transporter C6Y56_RS06135 ENOG4107T0X DNA ligase C6Y56_RS06145 ENOG4105CUJ penicillin amidase C6Y56_RS06155 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C6Y56_RS06165 ENOG4105K5B UPF0225 protein C6Y56_RS06175 ENOG4105CDV Ompa motb domain protein C6Y56_RS06180 ENOG4105UYK outer membrane protein a C6Y56_RS06200 ENOG4105DVT helicase C6Y56_RS06220 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) C6Y56_RS06250 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C6Y56_RS06260 ENOG4105DZ0 fad dependent oxidoreductase C6Y56_RS06275 ENOG4105HEI LysR family (Transcriptional regulator C6Y56_RS06290 ENOG4105E18 UPF0276 protein C6Y56_RS06300 ENOG4108IV0 ABC, transporter C6Y56_RS06305 ENOG4105C0Z ABC transporter C6Y56_RS06310 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C6Y56_RS06315 ENOG4105C32 Amino acid ABC transporter (Permease) C6Y56_RS06320 ENOG4105CP9 extracellular ligand-binding receptor C6Y56_RS06335 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C6Y56_RS06340 ENOG4105BZU Histidine kinase C6Y56_RS06345 ENOG4105PI0 Ferredoxin C6Y56_RS06350 ENOG4108I5G Major Facilitator superfamily C6Y56_RS06355 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) C6Y56_RS06375 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS06385 ENOG4105CJ3 phosphate transporter C6Y56_RS06395 ENOG4107HP6 Transcriptional regulator C6Y56_RS06400 ENOG4105D2S major facilitator superfamily C6Y56_RS06415 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS06430 ENOG4105CSH Transporter C6Y56_RS06435 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase C6Y56_RS06440 ENOG4105F2Z 3-oxoadipate enol-lactonase C6Y56_RS06445 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C6Y56_RS06465 ENOG41090KI Outer membrane porin C6Y56_RS06470 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C6Y56_RS06475 ENOG4105BZS acriflavin resistance protein C6Y56_RS06480 ENOG4105C1P efflux transporter, rnd family, mfp subunit C6Y56_RS06490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS06495 ENOG4105F27 Major Facilitator C6Y56_RS06535 ENOG4105CH2 amidohydrolase C6Y56_RS06540 ENOG4105CSH Transporter C6Y56_RS06545 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C6Y56_RS06560 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C6Y56_RS06565 ENOG4107QK4 glycoside hydrolase, family 3 domain protein C6Y56_RS06570 ENOG4108V0P LemA family C6Y56_RS06575 ENOG4105HA9 of methanol dehydrogenase type C6Y56_RS06590 ENOG4105T38 integral membrane protein C6Y56_RS06595 ENOG4107R7Y intracellular protease Pfpi family C6Y56_RS06600 ENOG4105KWI UPF0339 protein C6Y56_RS06605 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C6Y56_RS06610 ENOG4108S8N class II Aldolase C6Y56_RS06625 ENOG4105C0A alcohol dehydrogenase C6Y56_RS06635 ENOG4105EGI Transcriptional regulator C6Y56_RS06640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C6Y56_RS06645 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C6Y56_RS06650 ENOG4105CSP Major Facilitator Superfamily C6Y56_RS06675 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C6Y56_RS06685 ENOG4105BZU Histidine kinase C6Y56_RS06705 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C6Y56_RS06735 ENOG4108YI3 3-hydroxyacyl-CoA-acyl carrier protein transferase C6Y56_RS06740 ENOG4105I08 Pseudouridine synthase C6Y56_RS06760 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C6Y56_RS06765 ENOG4105EIG urea carboxylase-associated protein 1 C6Y56_RS06820 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C6Y56_RS06850 ENOG4105EPF Outer membrane porin C6Y56_RS06875 ENOG4105Y75 tpr repeat protein C6Y56_RS06885 ENOG4108IYU L-aspartate oxidase C6Y56_RS06890 ENOG4105EMN RNA polymerase sigma factor C6Y56_RS06895 ENOG41069E1 anti sigma-E protein RseA C6Y56_RS06900 ENOG4105VQK sigma E regulatory protein, MucB RseB C6Y56_RS06905 ENOG4105C0H protease C6Y56_RS06910 ENOG4105ERG peptidase m48, ste24p C6Y56_RS06915 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C6Y56_RS06920 ENOG4105C02 permease C6Y56_RS06925 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C6Y56_RS06935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C6Y56_RS06940 ENOG4105GJM (LipO)protein C6Y56_RS06945 ENOG4105Q2H domain protein C6Y56_RS06950 ENOG4105C8V SAICAR synthetase C6Y56_RS06970 ENOG4107EPN Domain of unknown function (DUF1508) C6Y56_RS07005 ENOG4105G2Y Transcriptional regulator C6Y56_RS07010 ENOG4105DJ2 Major Facilitator Superfamily C6Y56_RS07015 ENOG4105DIJ Phosphoethanolamine transferase C6Y56_RS07025 ENOG4105VNG YcgL domain-containing protein C6Y56_RS07040 ENOG4108ZZ3 UPF0260 protein C6Y56_RS07060 ENOG4105N1F Hnh endonuclease C6Y56_RS07080 ENOG4105CUG Oligopeptidase b C6Y56_RS07090 ENOG4105E7A Glutamine amidotransferase C6Y56_RS07100 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family C6Y56_RS07110 ENOG4105E7W lamb ycsf family protein C6Y56_RS07115 ENOG4105P4J Allophanate hydrolase, subunit 1 C6Y56_RS07120 ENOG4107R7A Allophanate hydrolase subunit 2 C6Y56_RS07130 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C6Y56_RS07150 ENOG4105C6T cysteine synthase C6Y56_RS07180 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) C6Y56_RS07185 ENOG4105CQ7 ATP-dependent helicase C6Y56_RS07215 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C6Y56_RS07220 ENOG4105BZ1 (ABC) transporter C6Y56_RS07225 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C6Y56_RS07245 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C6Y56_RS07250 ENOG4105EMK carboxylate amino acid amine transporter C6Y56_RS07255 ENOG4105CR8 Transcriptional regulator C6Y56_RS07260 ENOG4105CHJ isochorismatase hydrolase C6Y56_RS07265 ENOG4105CUY Mechanosensitive ion channel C6Y56_RS07270 ENOG4105C1J atp-dependent rna helicase C6Y56_RS07315 ENOG4105QNR S1 RNA binding domain protein C6Y56_RS07325 ENOG4108Q5Y Membrane C6Y56_RS07335 ENOG4105EGI Transcriptional regulator C6Y56_RS07365 ENOG4105CYW agmatinase C6Y56_RS07370 ENOG4105EVZ LysR family transcriptional regulator C6Y56_RS07380 ENOG4107QZV Type I secretion membrane fusion protein C6Y56_RS07445 ENOG4105WD1 Membrane C6Y56_RS07455 ENOG4105C9U ATP-dependent DNA helicase RecQ C6Y56_RS07470 ENOG4105D78 K07001 NTE family protein C6Y56_RS07485 ENOG4105E7U AraC family transcriptional regulator C6Y56_RS07510 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C6Y56_RS07515 ENOG41069NU Nitroreductase C6Y56_RS07520 ENOG4105DHQ Histidine kinase C6Y56_RS07530 ENOG4105E3W Two component transcriptional regulator (Winged helix family C6Y56_RS07540 ENOG4105K9H YciI-like protein C6Y56_RS07545 ENOG4107835 probably involved in intracellular septation (By similarity) C6Y56_RS07555 ENOG4107RTD sua5 ycio yrdc ywlc family protein C6Y56_RS07565 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C6Y56_RS07575 ENOG4105FE9 pseudouridine synthase C6Y56_RS07580 ENOG4105C85 amino acid C6Y56_RS07585 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C6Y56_RS07600 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C6Y56_RS07605 ENOG4108YZN class I peptide chain release factor C6Y56_RS07620 ENOG4105CGF Aromatic amino acid aminotransferase C6Y56_RS07625 ENOG41090A4 Pterin carbinolamine dehydratase C6Y56_RS07630 ENOG4105MIR Phenylalanine 4-monooxygenase C6Y56_RS07635 ENOG4108JU8 Transcriptional regulator C6Y56_RS07640 ENOG4108KPB Flagellar basal-body rod protein FlgF C6Y56_RS07645 ENOG4105CGA flagellar basal-body rod protein FlgG C6Y56_RS07650 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C6Y56_RS07655 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C6Y56_RS07660 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C6Y56_RS07665 ENOG4105E1Q flagellar hook-associated protein C6Y56_RS07670 ENOG4105DTJ flagellar hook-associated protein C6Y56_RS07685 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C6Y56_RS07690 ENOG4105FAW cDP-glucose 4,6-dehydratase C6Y56_RS07695 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C6Y56_RS07705 ENOG4108IAJ Nad-dependent epimerase dehydratase C6Y56_RS07725 ENOG4105C5E polysaccharide biosynthesis protein C6Y56_RS07730 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C6Y56_RS07740 ENOG4105F0R Cytidylyltransferase C6Y56_RS07750 ENOG4105D2T synthase C6Y56_RS07755 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C6Y56_RS07770 ENOG4105I03 Flagellin C6Y56_RS07780 ENOG4105DTS flagellar hook-associated C6Y56_RS07785 ENOG4105MQ3 flagellar protein FliS C6Y56_RS07800 ENOG4105BZU Histidine kinase C6Y56_RS07810 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C6Y56_RS07815 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C6Y56_RS07820 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C6Y56_RS07830 ENOG4108JIR Flagellum-specific ATP synthase C6Y56_RS07845 ENOG4108KXV response regulator C6Y56_RS07860 ENOG4107ZI8 flagellar basal body-associated protein flil C6Y56_RS07865 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C6Y56_RS07870 ENOG4105DD5 Flagellar motor switch protein C6Y56_RS07875 ENOG4105VTB flagellar biosynthesis protein fliO C6Y56_RS07880 ENOG4105CN7 Flagellar biosynthetic protein FliP C6Y56_RS07885 ENOG4105VS8 Flagellar biosynthetic protein fliq C6Y56_RS07890 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C6Y56_RS07895 ENOG4105D00 flagellar biosynthetic protein flhB C6Y56_RS07925 ENOG4105D7B Flagellar biosynthesis protein flha C6Y56_RS07930 ENOG4105FZW flagellar biosynthesis regulator FlhF C6Y56_RS07940 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C6Y56_RS07945 ENOG4108VYJ response regulator receiver protein C6Y56_RS07950 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) C6Y56_RS07960 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C6Y56_RS07965 ENOG4105E14 MotA TolQ exbB proton channel C6Y56_RS07970 ENOG4106VK6 Flagellar motor protein C6Y56_RS07975 ENOG4107QJE Chromosome Partitioning Protein C6Y56_RS07985 ENOG4108V3W Chemotaxis protein, CheW C6Y56_RS07995 ENOG4105D00 flagellar biosynthetic protein flhB C6Y56_RS08005 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS08010 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) C6Y56_RS08015 ENOG41060IM Heme exporter protein C6Y56_RS08025 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) C6Y56_RS08030 ENOG4105DA4 cytochrome c-type biogenesis protein C6Y56_RS08040 ENOG4105KWW Biogenesis protein C6Y56_RS08045 ENOG4108M1T Cytochrome c-type biogenesis protein C6Y56_RS08060 ENOG4105VT3 DNA binding domain protein, excisionase family C6Y56_RS08065 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin C6Y56_RS08070 ENOG4105EQ0 Major Facilitator superfamily C6Y56_RS08080 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C6Y56_RS08085 ENOG4105EYW Ion transport protein C6Y56_RS08095 ENOG4105CA9 Pyruvate kinase C6Y56_RS08105 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C6Y56_RS08110 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C6Y56_RS08115 ENOG41060W2 glyoxylate carboligase C6Y56_RS08130 ENOG4108R86 Transcriptional regulator C6Y56_RS08135 ENOG4105CKW Inner membrane protein yedI C6Y56_RS08140 ENOG410903C (LipO)protein C6Y56_RS08165 ENOG41062QD Membrane C6Y56_RS08170 ENOG4107QN1 sodium solute C6Y56_RS08175 ENOG4105BZN citrate synthase C6Y56_RS08180 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit C6Y56_RS08185 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein C6Y56_RS08190 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) C6Y56_RS08195 ENOG4105E33 succinate dehydrogenase C6Y56_RS08200 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C6Y56_RS08205 ENOG4105C7S Dehydrogenase C6Y56_RS08210 ENOG4107QN2 dihydrolipoyl dehydrogenase C6Y56_RS08215 ENOG4105CMV Succinyl-CoA synthetase subunit beta C6Y56_RS08220 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C6Y56_RS08225 ENOG4105CWM branched-chain amino acid transport system II carrier protein C6Y56_RS08255 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C6Y56_RS08265 ENOG4105EUB pirin domain protein C6Y56_RS08290 ENOG4108V3E phosphoribosylglycinamide formyltransferase C6Y56_RS08295 ENOG4105CXB phosphoribosylaminoimidazole synthetase C6Y56_RS08305 ENOG4105C02 permease C6Y56_RS08310 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) C6Y56_RS08315 ENOG4107TT5 NLP P60 protein C6Y56_RS08320 ENOG4105K4H Nlp p60 protein C6Y56_RS08335 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase C6Y56_RS08340 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C6Y56_RS08345 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase C6Y56_RS08350 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) C6Y56_RS08355 ENOG4105EFT decarboxylase C6Y56_RS08360 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C6Y56_RS08365 ENOG4108YZT Adenosylcobinamide kinase C6Y56_RS08370 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) C6Y56_RS08375 ENOG4108TGR phosphatase C6Y56_RS08380 ENOG4105GN9 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) C6Y56_RS08400 ENOG4105ISI outer membrane protein, OMPP1 FadL TodX family C6Y56_RS08420 ENOG4105CGY Dna recombination protein C6Y56_RS08425 ENOG4105BZU Histidine kinase C6Y56_RS08440 ENOG41082W1 Cupin 2, conserved barrel domain protein C6Y56_RS08460 ENOG4105C09 Bile acid C6Y56_RS08465 ENOG4105DH7 May be involved in recombination (By similarity) C6Y56_RS08500 ENOG4108V1T peptidylprolyl cis-trans isomerase C6Y56_RS08530 ENOG4105BZU Histidine kinase C6Y56_RS08535 ENOG4105CN1 protease C6Y56_RS08550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS08560 ENOG4105F38 ABC transporter, permease C6Y56_RS08580 ENOG4105D8X mechanosensitive ion channel C6Y56_RS08590 ENOG4105DFM M18 family aminopeptidase C6Y56_RS08600 ENOG4105D3G Pseudouridine synthase C6Y56_RS08605 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) C6Y56_RS08610 ENOG4107QMS site-determining protein C6Y56_RS08615 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C6Y56_RS08620 ENOG4105D1S lipid A biosynthesis C6Y56_RS08645 ENOG4105C2W permease C6Y56_RS08655 ENOG4108Z2U ureidoglycolate hydrolase C6Y56_RS08660 ENOG4105DHG Allantoate amidinohydrolase C6Y56_RS08675 ENOG4105VT2 5-hydroxyisourate hydrolase C6Y56_RS08690 ENOG4105C7N Xanthine uracil vitamin C permease C6Y56_RS08700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C6Y56_RS08710 ENOG4105EUJ GTP cyclohydrolase i C6Y56_RS08715 ENOG4108DG9 Smr protein MutS2 C6Y56_RS08730 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) C6Y56_RS08745 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C6Y56_RS08755 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C6Y56_RS08760 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C6Y56_RS08765 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) C6Y56_RS08785 ENOG4105JXB ankyrin repeat-containing protein C6Y56_RS08800 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C6Y56_RS08835 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS08840 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C6Y56_RS08845 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C6Y56_RS08850 ENOG4105D7N magnesium and cobalt transport protein CorA C6Y56_RS08855 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase C6Y56_RS08870 ENOG4105K8R UPF0145 protein C6Y56_RS08900 ENOG4105CNA YD repeat protein C6Y56_RS08900 ENOG4105CNA YD repeat protein C6Y56_RS08905 ENOG4107YBY Hydrolase C6Y56_RS08910 ENOG4105F6U Short-chain dehydrogenase reductase Sdr C6Y56_RS08915 ENOG4105JQN Transcriptional regulator C6Y56_RS08920 ENOG410633P Hydantoin racemase C6Y56_RS08925 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C6Y56_RS08935 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein C6Y56_RS08940 ENOG4105CRQ synthase (Component I) C6Y56_RS08955 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C6Y56_RS08960 ENOG4105DRR Transcriptional regulator, GntR family C6Y56_RS08965 ENOG4105CR4 methylisocitrate lyase C6Y56_RS08970 ENOG4105BZN citrate synthase C6Y56_RS08975 ENOG4108I0Z Aconitate hydratase C6Y56_RS08980 ENOG4105C7F AcnD-accessory protein PrpF C6Y56_RS08985 ENOG4105DXD 2-methylcitrate dehydratase C6Y56_RS09000 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C6Y56_RS09015 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) C6Y56_RS09040 ENOG4105CDV Ompa motb domain protein C6Y56_RS09055 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C6Y56_RS09060 ENOG4108IFG nitrite reductase, (NAD(P)H) C6Y56_RS09085 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C6Y56_RS09090 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) C6Y56_RS09095 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C6Y56_RS09105 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C6Y56_RS09110 ENOG41090ED Protein with unknown function (DUF469) C6Y56_RS09115 ENOG4105DKK Benzoate C6Y56_RS09120 ENOG4107XBN GntR Family Transcriptional Regulator C6Y56_RS09125 ENOG4107QUY Guanine deaminase C6Y56_RS09155 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) C6Y56_RS09160 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C6Y56_RS09185 ENOG4107QMP dna polymerase iii subunits gamma and tau C6Y56_RS09190 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C6Y56_RS09195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C6Y56_RS09200 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C6Y56_RS09205 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS09210 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C6Y56_RS09225 ENOG4105D4P Coproporphyrinogen iii oxidase C6Y56_RS09250 ENOG4105C58 cytochrome c oxidase accessory protein ccog C6Y56_RS09265 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) C6Y56_RS09280 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C6Y56_RS09285 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) C6Y56_RS09300 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C6Y56_RS09320 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C6Y56_RS09350 ENOG4105BZP glycoside hydrolase 15-related C6Y56_RS09355 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C6Y56_RS09390 ENOG4105E0K tonB-dependent siderophore receptor C6Y56_RS09395 ENOG4105IBP Cyclic peptide transporter C6Y56_RS09420 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C6Y56_RS09425 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C6Y56_RS09430 ENOG4105DJY efflux transporter, rnd family, mfp subunit C6Y56_RS09440 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) C6Y56_RS09445 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C6Y56_RS09460 ENOG4108WQH regulatoR C6Y56_RS09465 ENOG4105BZU Histidine kinase C6Y56_RS09470 ENOG4105CV8 reductase C6Y56_RS09475 ENOG4105EUB pirin domain protein C6Y56_RS09485 ENOG4105CGK Exodeoxyribonuclease III C6Y56_RS09490 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C6Y56_RS09505 ENOG4105C2W permease C6Y56_RS09525 ENOG4105CGF Aromatic amino acid aminotransferase C6Y56_RS09530 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C6Y56_RS09545 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C6Y56_RS09575 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C6Y56_RS09585 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) C6Y56_RS09600 ENOG4105QFC Hsc56 co-chaperone of HscC C6Y56_RS09605 ENOG4105F7F Chaperone C6Y56_RS09610 ENOG4105BZU Histidine kinase C6Y56_RS09615 ENOG4108MP6 LysR family Transcriptional regulator C6Y56_RS09620 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C6Y56_RS09625 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C6Y56_RS09630 ENOG4105F2W methyltransferase C6Y56_RS09635 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C6Y56_RS09640 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C6Y56_RS09645 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C6Y56_RS09655 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C6Y56_RS09660 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C6Y56_RS09665 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C6Y56_RS09670 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C6Y56_RS09680 ENOG4105E96 Colicin v production protein C6Y56_RS09685 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C6Y56_RS09690 ENOG4105C28 cystathionine C6Y56_RS09695 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C6Y56_RS09715 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C6Y56_RS09725 ENOG4107TJ9 Cytochrome C6Y56_RS09730 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family C6Y56_RS09735 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS09790 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C6Y56_RS09795 ENOG4105C2J ABC transporter C6Y56_RS09800 ENOG4105CNN ABC, transporter C6Y56_RS09810 ENOG4108RVA ribokinase C6Y56_RS09815 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C6Y56_RS09850 ENOG4105C22 threonyL-tRNA synthetase C6Y56_RS09855 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C6Y56_RS09865 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C6Y56_RS09870 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C6Y56_RS09875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C6Y56_RS09880 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C6Y56_RS09900 ENOG4105CJ2 (LipO)protein C6Y56_RS09905 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C6Y56_RS09930 ENOG4105H3G oxidoreductase C6Y56_RS09950 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) C6Y56_RS09965 ENOG4105DH8 myo-inositol catabolism C6Y56_RS09970 ENOG4105C26 Dehydrogenase C6Y56_RS09980 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) C6Y56_RS09985 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C6Y56_RS09990 ENOG4105D9R oxidoreductase C6Y56_RS10000 ENOG4105C2J ABC transporter C6Y56_RS10005 ENOG4108HWV )-transporter C6Y56_RS10040 ENOG4105EQ2 LysR family Transcriptional regulator C6Y56_RS10090 ENOG4105EFZ amidohydrolase C6Y56_RS10095 ENOG4105CHJ isochorismatase hydrolase C6Y56_RS10110 ENOG4105CC0 LysR family Transcriptional regulator C6Y56_RS10120 ENOG4105D7Q type ii secretion system C6Y56_RS10125 ENOG4108VAU general secretion pathway protein G C6Y56_RS10130 ENOG4105E4C Lytic transglycosylase catalytic C6Y56_RS10165 ENOG4105F44 Two component transcriptional regulator, winged helix family C6Y56_RS10170 ENOG4107QHF type ii secretion system protein e C6Y56_RS10195 ENOG4105E4G Type IV pilus C6Y56_RS10225 ENOG4105P8Q Curli production assembly transport component CsgG C6Y56_RS10270 ENOG4105BZU Histidine kinase C6Y56_RS10290 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS10300 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) C6Y56_RS10335 ENOG4107BJW polysaccharide deacetylase C6Y56_RS10355 ENOG4105CG5 Glycosyl transferase (Group 1 C6Y56_RS10385 ENOG4105C6Y Udp-glucose 6-dehydrogenase C6Y56_RS10420 ENOG4107RBI VanW family C6Y56_RS10460 ENOG4105CS6 Rhs element vgr protein C6Y56_RS10465 ENOG4108WC9 type VI secretion system effector, hcp1 family C6Y56_RS10470 ENOG4105E32 cytoplasmic protein C6Y56_RS10475 ENOG4106HB6 Alpha beta hydrolase C6Y56_RS10480 ENOG4105F95 Monooxygenase C6Y56_RS10485 ENOG4105BZU Histidine kinase C6Y56_RS10495 ENOG4108JZP Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate (By similarity) C6Y56_RS10500 ENOG4105F4X arginine C6Y56_RS10505 ENOG4108T2Z Arginine C6Y56_RS10510 ENOG4105CUB amino acid C6Y56_RS10525 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) C6Y56_RS10555 ENOG4105E89 ABC transporter C6Y56_RS10585 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C6Y56_RS10590 ENOG4105CC0 LysR family Transcriptional regulator C6Y56_RS10600 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS10610 ENOG4105D6N CoA-transferase, subunit a C6Y56_RS10615 ENOG4108M0I Transcriptional regulator C6Y56_RS10625 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C6Y56_RS10630 ENOG4105E18 UPF0276 protein C6Y56_RS10640 ENOG4105E0F Histidine kinase C6Y56_RS10680 ENOG4105VE1 Phosphatidylcholine synthase C6Y56_RS10700 ENOG4105DQE DNA ligase C6Y56_RS10715 ENOG4108NVR Methyl-accepting chemotaxis C6Y56_RS10720 ENOG4105DWT malate dehydrogenase (quinone) C6Y56_RS10735 ENOG4107XM9 (LipO)protein C6Y56_RS10745 ENOG4105C7W Xanthine dehydrogenase C6Y56_RS10750 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding C6Y56_RS10755 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit C6Y56_RS10775 ENOG4105KCV RNA signal recognition particle 4.5S RNA C6Y56_RS10785 ENOG4107XID 2'-5' rna ligase C6Y56_RS10795 ENOG4105D38 putrescine abc transporter C6Y56_RS10800 ENOG4105F38 ABC transporter, permease C6Y56_RS10805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS10810 ENOG4108Z86 Glutamine amidotransferase C6Y56_RS10815 ENOG4105CFQ glutamine synthetase C6Y56_RS10820 ENOG4105C26 Dehydrogenase C6Y56_RS10825 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS10830 ENOG4107VRI Transcriptional regulator C6Y56_RS10870 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C6Y56_RS10885 ENOG4105Y49 secretion protein, HlyD family C6Y56_RS10900 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF C6Y56_RS10915 ENOG4105E98 transcriptional regulator DeoR family C6Y56_RS10920 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS10925 ENOG4105CFQ glutamine synthetase C6Y56_RS10935 ENOG4108ZAF Molybdopterin C6Y56_RS10940 ENOG4105M00 molybdopterin converting factor, subunit 1 C6Y56_RS10950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C6Y56_RS10955 ENOG4105C5Q Transcriptional regulator C6Y56_RS10960 ENOG4108RIR Molybdenum cofactor biosynthesis protein C6Y56_RS10965 ENOG4105CVM Molybdenum cofactor synthesis domain protein C6Y56_RS10970 ENOG4108Y50 Glutathione-dependent formaldehyde-activating Gfa C6Y56_RS10975 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS10995 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C6Y56_RS11000 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C6Y56_RS11015 ENOG4105BZU Histidine kinase C6Y56_RS11060 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C6Y56_RS11065 ENOG4105BZU Histidine kinase C6Y56_RS11095 ENOG4108M0I Transcriptional regulator C6Y56_RS11100 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C6Y56_RS11105 ENOG4108JQ5 ABC transporter C6Y56_RS11110 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C6Y56_RS11115 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C6Y56_RS11125 ENOG4105E43 Extracellular solute-binding protein, family 5 C6Y56_RS11130 ENOG4105E9H Lytic Murein transglycosylase C6Y56_RS11135 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C6Y56_RS11145 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C6Y56_RS11150 ENOG4107RZZ dna polymerase iii epsilon subunit C6Y56_RS11155 ENOG4105CXN decarboxylase C6Y56_RS11175 ENOG4108YYH Nadph-dependent fmn reductase C6Y56_RS11190 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C6Y56_RS11195 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C6Y56_RS11200 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) C6Y56_RS11205 ENOG4105VUT cytoplasmic protein C6Y56_RS11215 ENOG4105CD8 aminopeptidase N C6Y56_RS11220 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) C6Y56_RS11225 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) C6Y56_RS11245 ENOG4108ZX6 Electron transport protein SCO1 SenC C6Y56_RS11255 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C6Y56_RS11280 ENOG4105DJY efflux transporter, rnd family, mfp subunit C6Y56_RS11285 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C6Y56_RS11295 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C6Y56_RS11300 ENOG4105EU8 FAD linked oxidase domain protein C6Y56_RS11305 ENOG4105CQB FAD linked oxidase domain protein C6Y56_RS11310 ENOG4105CYM Glutathione S-transferase C6Y56_RS11315 ENOG4105CSH Transporter C6Y56_RS11325 ENOG4105E5Q amino acid AbC transporter C6Y56_RS11330 ENOG4105EAB amino acid AbC transporter C6Y56_RS11340 ENOG4105C7B Threonine dehydratase C6Y56_RS11355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS11365 ENOG4108WUH Transcriptional regulator, TetR family C6Y56_RS11370 ENOG4105CF7 AraC family transcriptional regulator C6Y56_RS11375 ENOG4105E1F short-chain dehydrogenase reductase C6Y56_RS11380 ENOG4105KAV tspo and mbr like protein C6Y56_RS11390 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C6Y56_RS11395 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C6Y56_RS11420 ENOG4105DU6 RNA polymerase C6Y56_RS11445 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) C6Y56_RS11460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS11465 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C6Y56_RS11470 ENOG4108XHQ (2Fe-2S)-binding domain protein C6Y56_RS11475 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C6Y56_RS11480 ENOG4105EQ0 Major Facilitator superfamily C6Y56_RS11485 ENOG4105HEI LysR family (Transcriptional regulator C6Y56_RS11510 ENOG4105WQT MbtH domain protein C6Y56_RS11545 ENOG4105DQ4 alcohol dehydrogenase C6Y56_RS11560 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C6Y56_RS11565 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C6Y56_RS11575 ENOG4107R7A Allophanate hydrolase subunit 2 C6Y56_RS11595 ENOG4105EQ2 LysR family Transcriptional regulator C6Y56_RS11600 ENOG4105DFH Transport of potassium into the cell (By similarity) C6Y56_RS11625 ENOG4105EUZ Beta-lactamase domain protein C6Y56_RS11635 ENOG4105DDY UPF0142 protein ycaO C6Y56_RS11645 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C6Y56_RS11670 ENOG4105CHJ isochorismatase hydrolase C6Y56_RS11695 ENOG4108HWW ABC transporter C6Y56_RS11700 ENOG4105C2J ABC transporter C6Y56_RS11705 ENOG4105DFW ABC transporter C6Y56_RS11710 ENOG4105C93 Xylose Isomerase C6Y56_RS11715 ENOG4105T16 Transcriptional regulator (AraC family) C6Y56_RS11720 ENOG4105MWK D-amino acid dehydrogenase, small subunit C6Y56_RS11730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C6Y56_RS11735 ENOG4105CTU Proline racemase C6Y56_RS11740 ENOG4107QTZ amino acid C6Y56_RS11795 ENOG4105DTQ mandelate racemase muconate lactonizing C6Y56_RS11800 ENOG4105NN7 muconolactone delta-isomerase C6Y56_RS11805 ENOG410626B catechol 1,2-dioxygenase C6Y56_RS11810 ENOG4108WC9 type VI secretion system effector, hcp1 family C6Y56_RS11820 ENOG4105CNA YD repeat protein C6Y56_RS11845 ENOG4105D01 (LipO)protein C6Y56_RS11850 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS11855 ENOG4108UMI ABC transporter, permease C6Y56_RS11920 ENOG4105EJC lysr family transcriptional regulator C6Y56_RS11925 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C6Y56_RS11930 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C6Y56_RS11935 ENOG4108UQ8 endoribonuclease L-psp C6Y56_RS11955 ENOG4108UQ8 endoribonuclease L-psp C6Y56_RS11975 ENOG4105DHQ Histidine kinase C6Y56_RS11980 ENOG4105XJC Two component transcriptional regulator (Winged helix family C6Y56_RS12010 ENOG4105CSH Transporter C6Y56_RS12020 ENOG4105KME endoribonuclease L-psp C6Y56_RS12025 ENOG4108JJA ABC, transporter C6Y56_RS12030 ENOG4105CFP Peptidase U32 C6Y56_RS12045 ENOG4105DVW rieske (2Fe-2S) C6Y56_RS12055 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS12060 ENOG4108IJ7 Glycine betaine C6Y56_RS12065 ENOG4108HQS Glycine betaine C6Y56_RS12070 ENOG4105GIJ Glycine betaine C6Y56_RS12075 ENOG4105ECQ AraC Family Transcriptional Regulator C6Y56_RS12085 ENOG4105C54 Major Facilitator superfamily C6Y56_RS12090 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C6Y56_RS12095 ENOG4105C26 Dehydrogenase C6Y56_RS12100 ENOG4105ECQ AraC Family Transcriptional Regulator C6Y56_RS12150 ENOG4105EGS Mechanosensitive ion channel C6Y56_RS12155 ENOG4105CAU Arsenical resistance protein, ArsH C6Y56_RS12160 ENOG4107WAU Protein tyrosine phosphatase C6Y56_RS12165 ENOG41082YX Transcriptional regulator, arsr family C6Y56_RS12190 ENOG4105CF7 AraC family transcriptional regulator C6Y56_RS12205 ENOG4105CHR reductase C6Y56_RS12210 ENOG4105ECQ AraC Family Transcriptional Regulator C6Y56_RS12215 ENOG4105EMU Dehydrogenase C6Y56_RS12220 ENOG410645S MarR family Transcriptional regulator C6Y56_RS12280 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C6Y56_RS12295 ENOG4105CC0 LysR family Transcriptional regulator C6Y56_RS12315 ENOG4105CW7 secretion protein, HlyD family C6Y56_RS12325 ENOG4108VCA G U mismatch-specific DNA glycosylase C6Y56_RS12345 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein C6Y56_RS12355 ENOG4108W3Q Transcriptional regulator C6Y56_RS12400 ENOG4108VA1 ABC transporter C6Y56_RS12405 ENOG4107T9Q phosphonate abc transporter C6Y56_RS12415 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C6Y56_RS12420 ENOG4105F1S paraquat-inducible protein a C6Y56_RS12430 ENOG4108K3A Glutathione S-transferase C6Y56_RS12435 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS12455 ENOG4108ZHJ Organic hydroperoxide resistance protein C6Y56_RS12465 ENOG4105CPQ Dehydrogenase C6Y56_RS12480 ENOG4105Q9Y Universal stress protein C6Y56_RS12485 ENOG41090JX gCN5-related N-acetyltransferase C6Y56_RS12500 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C6Y56_RS12505 ENOG4107QRI Phosphoketolase C6Y56_RS12515 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C6Y56_RS12535 ENOG4105CY0 Metallo-Beta-Lactamase C6Y56_RS12540 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C6Y56_RS12550 ENOG4105Q9Y Universal stress protein C6Y56_RS12595 ENOG4105DCG PHP domain protein C6Y56_RS12615 ENOG4106K4M Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C6Y56_RS12620 ENOG41081QV Universal stress protein C6Y56_RS12635 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C6Y56_RS12655 ENOG4105VN1 Heat shock protein C6Y56_RS12660 ENOG4105D5Q Arginine ornithine antiporter C6Y56_RS12665 ENOG4105BZ1 (ABC) transporter C6Y56_RS12685 ENOG4105CR8 Transcriptional regulator C6Y56_RS12840 ENOG4105RWQ Protein of unknown function (DUF1364) C6Y56_RS12855 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C6Y56_RS12985 ENOG4105NVB glycoside hydrolase, family 19 C6Y56_RS13015 ENOG4108MN8 Membrane C6Y56_RS13070 ENOG4105E02 MotA TolQ exbB proton channel C6Y56_RS13075 ENOG4105SG9 biopolymer transport protein, ExbD C6Y56_RS13100 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C6Y56_RS13125 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C6Y56_RS13130 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C6Y56_RS13145 ENOG4108KKZ (LipO)protein C6Y56_RS13150 ENOG4105GRZ Ycii-related protein C6Y56_RS13155 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C6Y56_RS13160 ENOG4105ENT Efflux transporter rnd family, mfp subunit C6Y56_RS13170 ENOG4105BZS acriflavin resistance protein C6Y56_RS13175 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C6Y56_RS13180 ENOG4105BZU Histidine kinase C6Y56_RS13185 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C6Y56_RS13190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C6Y56_RS13195 ENOG4105C58 cytochrome c oxidase accessory protein ccog C6Y56_RS13205 ENOG4108302 MgtC SapB transporter C6Y56_RS13215 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) C6Y56_RS13225 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C6Y56_RS13235 ENOG4105X23 Endonuclease Exonuclease phosphatase C6Y56_RS13285 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C6Y56_RS13290 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C6Y56_RS13295 ENOG4105C5I Dehydrogenase C6Y56_RS13300 ENOG4105CPT Alpha beta hydrolase C6Y56_RS13305 ENOG4105W39 Membrane C6Y56_RS13315 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS13345 ENOG4107QF7 multi-drug C6Y56_RS13365 ENOG4107SQI penicillin amidase C6Y56_RS13380 ENOG4105DG4 malate L-lactate dehydrogenase C6Y56_RS13400 ENOG4105ES4 Nitrilase C6Y56_RS13415 ENOG4105C2W permease C6Y56_RS13430 ENOG4105CYW agmatinase C6Y56_RS13445 ENOG4105D6Z AFG1 family ATPase C6Y56_RS13465 ENOG4105CNM Receptor C6Y56_RS13470 ENOG4105DIJ Phosphoethanolamine transferase C6Y56_RS13480 ENOG4108J5G 6-phosphogluconate dehydrogenase C6Y56_RS13485 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C6Y56_RS13490 ENOG410667J hydrolase C6Y56_RS13495 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C6Y56_RS13510 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS13555 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS13560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C6Y56_RS13575 ENOG4105EXG Transcriptional regulator C6Y56_RS13580 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C6Y56_RS13595 ENOG4105C5H ABC transporter C6Y56_RS13610 ENOG4105FDF Could be involved in DNA repair (By similarity) C6Y56_RS13620 ENOG4105D8V Glucose sorbosone dehydrogenase C6Y56_RS13635 ENOG4105D7N magnesium and cobalt transport protein CorA C6Y56_RS13645 ENOG4105C7B Threonine dehydratase C6Y56_RS13650 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) C6Y56_RS13705 ENOG4105EPF Outer membrane porin C6Y56_RS13715 ENOG4105D7K pfkb domain protein C6Y56_RS13720 ENOG4105CMG Carbohydrate kinase C6Y56_RS13725 ENOG4105DEI Mannitol dehydrogenase C6Y56_RS13730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS13740 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C6Y56_RS13775 ENOG4105BZU Histidine kinase C6Y56_RS13780 ENOG4105BZU Histidine kinase C6Y56_RS13785 ENOG4107Z5C methylesterase C6Y56_RS13790 ENOG4105BZU Histidine kinase C6Y56_RS13825 ENOG4105Y49 secretion protein, HlyD family C6Y56_RS13845 ENOG4105KAF membrAne C6Y56_RS13855 ENOG4105F27 Major Facilitator C6Y56_RS13885 ENOG4105C2I pirin domain protein C6Y56_RS13890 ENOG41088T4 Helicase IV C6Y56_RS13905 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS13915 ENOG4108HM4 ABC transporter C6Y56_RS13930 ENOG4108JJ6 Type I secretion system ATPase C6Y56_RS13935 ENOG4107QZV Type I secretion membrane fusion protein C6Y56_RS13940 ENOG4105DFG type I secretion outer membrane protein C6Y56_RS13975 ENOG4105F2V VRR-NUC domain-containing protein C6Y56_RS13980 ENOG4105DVT helicase C6Y56_RS14005 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C6Y56_RS14010 ENOG4105C87 Aminotransferase class I and II C6Y56_RS14020 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C6Y56_RS14025 ENOG4108MG3 formate dehydrogenase C6Y56_RS14030 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) C6Y56_RS14035 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) C6Y56_RS14040 ENOG4105EM7 Selenocysteine-specific translation elongation factor C6Y56_RS14055 ENOG4105J5J Outer membrane porin C6Y56_RS14060 ENOG4105E0F Histidine kinase C6Y56_RS14075 ENOG4108KKZ (LipO)protein C6Y56_RS14080 ENOG4105TW1 Carbohydrate-selective porin OprB C6Y56_RS14095 ENOG4107B2H carbonic anhydrase C6Y56_RS14115 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS14120 ENOG4105DEF Extracellular solute-binding protein, family 5 C6Y56_RS14130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C6Y56_RS14155 ENOG4105CWC Acetylornithine deacetylase C6Y56_RS14160 ENOG4105C26 Dehydrogenase C6Y56_RS14165 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C6Y56_RS14170 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase C6Y56_RS14175 ENOG4108JPW Aminotransferase C6Y56_RS14185 ENOG4108RYR transcriptional regulator AsnC family C6Y56_RS14195 ENOG4107SDU Methyl-accepting chemotaxis C6Y56_RS14205 ENOG4108IJ7 Glycine betaine C6Y56_RS14220 ENOG4107YV3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C6Y56_RS14235 ENOG4105BZU Histidine kinase C6Y56_RS14240 ENOG4108WQH regulatoR C6Y56_RS14245 ENOG4105BZU Histidine kinase C6Y56_RS14250 ENOG4105X0I Fimbrial C6Y56_RS14255 ENOG4108MQF Chaperone C6Y56_RS14260 ENOG4105CW0 outer membrane usher protein C6Y56_RS14270 ENOG41090KI Outer membrane porin C6Y56_RS14300 ENOG4108WQH regulatoR C6Y56_RS14305 ENOG4105BZU Histidine kinase C6Y56_RS14320 ENOG4105CW0 outer membrane usher protein C6Y56_RS14325 ENOG4108VEV chaperone C6Y56_RS14330 ENOG4106EAR Fimbrial protein C6Y56_RS14345 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C6Y56_RS14360 ENOG4105E5Q amino acid AbC transporter C6Y56_RS14365 ENOG4105E89 ABC transporter C6Y56_RS14445 ENOG4105EMN RNA polymerase sigma factor C6Y56_RS14460 ENOG4105CFQ glutamine synthetase C6Y56_RS14465 ENOG4108HM4 ABC transporter C6Y56_RS14470 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS14475 ENOG4105DY2 Paraquat-inducible protein b C6Y56_RS14485 ENOG4105DHQ Histidine kinase C6Y56_RS14495 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C6Y56_RS14500 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C6Y56_RS14515 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS14520 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C6Y56_RS14525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C6Y56_RS14530 ENOG4105CKK Glycosyl transferase, family 2 C6Y56_RS14535 ENOG4105C3I Nad-dependent epimerase dehydratase C6Y56_RS14540 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C6Y56_RS14545 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C6Y56_RS14550 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) C6Y56_RS14560 ENOG4105C6Y Udp-glucose 6-dehydrogenase C6Y56_RS14570 ENOG4105XYF acetyltransferase C6Y56_RS14575 ENOG4105EVZ LysR family transcriptional regulator C6Y56_RS14580 ENOG4105CH7 arginosuccinase C6Y56_RS14585 ENOG4105DRP amino acid AbC transporter C6Y56_RS14595 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C6Y56_RS14615 ENOG4105E5W Transporter C6Y56_RS14630 ENOG4105E39 Enoyl-CoA hydratase C6Y56_RS14635 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS14640 ENOG4105E39 Enoyl-CoA hydratase C6Y56_RS14645 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS14650 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS14665 ENOG4108UQN AraC family transcriptional regulator C6Y56_RS14670 ENOG4105EKT )-iron permease C6Y56_RS14675 ENOG410650H (LipO)protein C6Y56_RS14685 ENOG410650H (LipO)protein C6Y56_RS14690 ENOG4105JIM Phosphatidylserine synthase C6Y56_RS14715 ENOG4105E09 nadh pyrophosphatase C6Y56_RS14720 ENOG4105E39 Enoyl-CoA hydratase C6Y56_RS14735 ENOG4105EMN RNA polymerase sigma factor C6Y56_RS14750 ENOG4108RWI nicotinamidase C6Y56_RS14755 ENOG4105JJR Histidine kinase C6Y56_RS14760 ENOG4107EXC regulatoR C6Y56_RS14765 ENOG4105C1P efflux transporter, rnd family, mfp subunit C6Y56_RS14770 ENOG4105BZS acriflavin resistance protein C6Y56_RS14780 ENOG4108M60 Transcriptional regulator C6Y56_RS14790 ENOG4105D7K pfkb domain protein C6Y56_RS14805 ENOG4105CHM Aminotransferase C6Y56_RS14815 ENOG4105BZW Glycerate kinase C6Y56_RS14820 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR C6Y56_RS14825 ENOG4105CSP Major Facilitator Superfamily C6Y56_RS14845 ENOG4105HEI LysR family (Transcriptional regulator C6Y56_RS14850 ENOG4105CPC Aldo Keto reductase C6Y56_RS14855 ENOG4105DTR rard protein C6Y56_RS14870 ENOG4108M0I Transcriptional regulator C6Y56_RS14895 ENOG4108JU3 Alkyl hydroperoxide reductase C6Y56_RS14900 ENOG4105D3R alkyl hydroperoxide reductase C6Y56_RS14915 ENOG4105DC8 reductase C6Y56_RS14925 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C6Y56_RS14965 ENOG4105CF1 Alkylated DNA repair protein C6Y56_RS14970 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C6Y56_RS14975 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family C6Y56_RS14985 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C6Y56_RS14990 ENOG4105E0C molybdate abc transporter C6Y56_RS14995 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS15005 ENOG4105C5H ABC transporter C6Y56_RS15025 ENOG4105EXC Acyl-transferase C6Y56_RS15055 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS15065 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C6Y56_RS15075 ENOG4107RTG Major Facilitator superfamily C6Y56_RS15080 ENOG4105CF7 AraC family transcriptional regulator C6Y56_RS15120 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C6Y56_RS15135 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C6Y56_RS15150 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C6Y56_RS15155 ENOG4105E43 Extracellular solute-binding protein, family 5 C6Y56_RS15160 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C6Y56_RS15165 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C6Y56_RS15170 ENOG4108JQ5 ABC transporter C6Y56_RS15175 ENOG4108JUA Transcriptional regulator C6Y56_RS15180 ENOG4105CY2 Citrate transporter C6Y56_RS15185 ENOG4105DTD Dehydrogenase C6Y56_RS15190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C6Y56_RS15195 ENOG4105CZX twitching motility protein C6Y56_RS15205 ENOG4105KQ5 peptidylprolyl cis-trans isomerase C6Y56_RS15210 ENOG4107SS6 2-dehydro-3-deoxygluconokinase C6Y56_RS15235 ENOG4105E5Q amino acid AbC transporter C6Y56_RS15240 ENOG4105E5Q amino acid AbC transporter C6Y56_RS15245 ENOG4107RP9 extracellular solute-binding protein, family 3 C6Y56_RS15255 ENOG4105EE5 Membrane protein terC C6Y56_RS15260 ENOG4105VUF Transcriptional regulator C6Y56_RS15285 ENOG4105CTK cobaltochelatase, cobn subunit C6Y56_RS15290 ENOG4107QRP cobalamin biosynthesis protein CobW C6Y56_RS15315 ENOG4108P62 biosynthesis protein (CbiG) C6Y56_RS15320 ENOG4105CIA precorrin-4 C(11)-methyltransferase C6Y56_RS15325 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) C6Y56_RS15340 ENOG4105C3R Methionine synthase C6Y56_RS15350 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C6Y56_RS15365 ENOG4105ERU peptidase C6Y56_RS15380 ENOG4108JQ5 ABC transporter C6Y56_RS15385 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C6Y56_RS15390 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C6Y56_RS15395 ENOG4105E43 Extracellular solute-binding protein, family 5 C6Y56_RS15400 ENOG4105D05 Receptor C6Y56_RS15405 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) C6Y56_RS15415 ENOG4108SF5 RNA Polymerase C6Y56_RS15420 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C6Y56_RS15455 ENOG4107MMM Anti-sigma-factor antagonist C6Y56_RS15460 ENOG4105FUA antagonist C6Y56_RS15465 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C6Y56_RS15475 ENOG4105BZU Histidine kinase C6Y56_RS15510 ENOG4105C0B DNA polymerase III (alpha subunit) C6Y56_RS15525 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C6Y56_RS15560 ENOG4105CBX hi0933 family C6Y56_RS15595 ENOG4108UPW ABC transporter C6Y56_RS15600 ENOG4105D7Q type ii secretion system C6Y56_RS15605 ENOG4107QHF type ii secretion system protein e C6Y56_RS15610 ENOG4105GVR general secretion pathway protein D C6Y56_RS15625 ENOG4108RTD type II secretion system protein K C6Y56_RS15630 ENOG4108VAU general secretion pathway protein G C6Y56_RS15655 ENOG4105ETE Transcriptional regulator (LacI family C6Y56_RS15665 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component C6Y56_RS15670 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component C6Y56_RS15680 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C6Y56_RS15685 ENOG4105EPF Outer membrane porin C6Y56_RS15760 ENOG4108WWZ General secretion pathway protein J C6Y56_RS15785 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C6Y56_RS15810 ENOG4105C7I Dehydrogenase C6Y56_RS15820 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C6Y56_RS15850 ENOG4107RH8 nuclease SbcCD subunit D C6Y56_RS15855 ENOG4105EYH Exonuclease C6Y56_RS15890 ENOG4105CZJ Aldehyde dehydrogenase C6Y56_RS15930 ENOG4108MXF Alpha Beta Hydrolase C6Y56_RS15935 ENOG4105C26 Dehydrogenase C6Y56_RS15945 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C6Y56_RS15950 ENOG4108KWP DNA-binding transcriptional regulator GlcC C6Y56_RS15955 ENOG4105E09 nadh pyrophosphatase C6Y56_RS15970 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C6Y56_RS15980 ENOG4105F38 ABC transporter, permease C6Y56_RS15990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS15995 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C6Y56_RS16005 ENOG4105C9X ppx gppa phosphatase C6Y56_RS16015 ENOG4105C28 cystathionine C6Y56_RS16035 ENOG4105BZU Histidine kinase C6Y56_RS16045 ENOG4105DHU Bile acid C6Y56_RS16050 ENOG4105R1U AraC Family Transcriptional Regulator C6Y56_RS16055 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C6Y56_RS16060 ENOG4105EZR dyp-type peroxidase family protein C6Y56_RS16065 ENOG4105DU1 integral membrane protein, terc C6Y56_RS16075 ENOG4105ETS cytosine purines uracil thiamine allantoin C6Y56_RS16085 ENOG4108M8W Monooxygenase C6Y56_RS16105 ENOG4105H3G oxidoreductase C6Y56_RS16110 ENOG4105KME endoribonuclease L-psp C6Y56_RS16120 ENOG4105CWC Acetylornithine deacetylase C6Y56_RS16125 ENOG4105ETS cytosine purines uracil thiamine allantoin C6Y56_RS16130 ENOG4108TGY Glutathione S-transferase C6Y56_RS16140 ENOG4105EGI Transcriptional regulator C6Y56_RS16145 ENOG4105C26 Dehydrogenase C6Y56_RS16150 ENOG4105C57 major facilitator superfamily C6Y56_RS16155 ENOG410642W LysR family Transcriptional regulator C6Y56_RS16165 ENOG4105CQB FAD linked oxidase domain protein C6Y56_RS16170 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS16205 ENOG4105GVF (ABC) transporter C6Y56_RS16215 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C6Y56_RS16220 ENOG4108RAV Conserved protein C6Y56_RS16255 ENOG4105EWT decarboxylase family C6Y56_RS16290 ENOG4105D65 subunit l C6Y56_RS16295 ENOG4108ZE9 Monovalent cation H antiporter subunit C C6Y56_RS16300 ENOG4107R4Z monovalent cation h antiporter subunit d C6Y56_RS16310 ENOG4105W4C monovalent cation H antiporter subunit F C6Y56_RS16315 ENOG4105KJM monovalent cation h antiporter subunit g C6Y56_RS16330 ENOG4105E0K tonB-dependent siderophore receptor C6Y56_RS16360 ENOG4108W2P Methyl-accepting chemotaxis C6Y56_RS16370 ENOG4108RXX maleylacetoacetate isomerase C6Y56_RS16375 ENOG4105F1N DNA alkylation repair C6Y56_RS16380 ENOG4105N14 lysine exporter protein LysE YggA C6Y56_RS16425 ENOG4105CPW cytochrome b561 C6Y56_RS16435 ENOG4108IQE Amp-dependent synthetase and ligase C6Y56_RS16455 ENOG4105XJC Two component transcriptional regulator (Winged helix family C6Y56_RS16460 ENOG4105DHQ Histidine kinase C6Y56_RS16480 ENOG4105CSH Transporter C6Y56_RS16490 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C6Y56_RS16510 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) C6Y56_RS16520 ENOG4105QNJ serralysin (EC 3.4.24.40) C6Y56_RS16525 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C6Y56_RS16545 ENOG4105DND Transcriptional regulator C6Y56_RS16550 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) C6Y56_RS16560 ENOG4107B2H carbonic anhydrase C6Y56_RS16570 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C6Y56_RS16575 ENOG4105CSV Glutaminase C6Y56_RS16585 ENOG4109045 doxx family C6Y56_RS16640 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C6Y56_RS16645 ENOG4105C4M (Ubiquinol oxidase) subunit I C6Y56_RS16655 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C6Y56_RS16660 ENOG4105FFC UPF0187 protein C6Y56_RS16665 ENOG4105JJR Histidine kinase C6Y56_RS16670 ENOG4107EXC regulatoR C6Y56_RS16675 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase C6Y56_RS16680 ENOG4105Q9Y Universal stress protein C6Y56_RS16690 ENOG4107QIJ Aconitate hydratase 2 C6Y56_RS16705 ENOG4105C44 Serine transporter C6Y56_RS16715 ENOG4105C5I Dehydrogenase C6Y56_RS16775 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C6Y56_RS16790 ENOG4105CS6 Rhs element vgr protein C6Y56_RS16810 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C6Y56_RS16815 ENOG4105EN6 Membrane C6Y56_RS16840 ENOG4105CE7 Amidase, hydantoinase carbamoylase family C6Y56_RS16845 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C6Y56_RS16850 ENOG4105CD3 dihydroorotase C6Y56_RS16855 ENOG4105BZ8 glutamate synthase C6Y56_RS16860 ENOG4107SJI Dehydrogenase C6Y56_RS16865 ENOG4108R86 Transcriptional regulator C6Y56_RS16910 ENOG41080HT Transcriptional regulator, arsr family C6Y56_RS16925 ENOG4108YXU transcriptional regulator AsnC family C6Y56_RS16930 ENOG4107R0V Pyruvate dehydrogenase C6Y56_RS16935 ENOG4105CPP Dehydrogenase, E1 component C6Y56_RS16940 ENOG4107QSN dihydrolipoamide acetyltransferase C6Y56_RS16945 ENOG4107QN2 dihydrolipoyl dehydrogenase C6Y56_RS16950 ENOG4105CM2 brancheD-chain amino acid aminotransferase C6Y56_RS16975 ENOG4105PGM cation diffusion facilitator family transporter C6Y56_RS17020 ENOG4105BZU Histidine kinase C6Y56_RS17035 ENOG4105CSH Transporter C6Y56_RS17045 ENOG4105F04 LysR family Transcriptional regulator C6Y56_RS17050 ENOG4105CKD glutathione-regulated potassium-efflux system protein C6Y56_RS17065 ENOG41065RR hydrogen cyanide synthase HcnA C6Y56_RS17085 ENOG4105UPP uncharacterized protein ydcA C6Y56_RS17090 ENOG4105ETX regulatoR C6Y56_RS17095 ENOG4105GR3 Histidine kinase C6Y56_RS17105 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C6Y56_RS17115 ENOG4107RSM transcriptional regulator C6Y56_RS17125 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C6Y56_RS17135 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 C6Y56_RS17145 ENOG4105DR4 Methyltransferase C6Y56_RS17165 ENOG4105DYS nad(p)h dehydrogenase (quinone) C6Y56_RS17230 ENOG4105XUA cytochrome c C6Y56_RS17235 ENOG4107U9B transcriptional regulator C6Y56_RS17240 ENOG4105T38 integral membrane protein C6Y56_RS17255 ENOG4105CHH sulfate transporter C6Y56_RS17265 ENOG4105KD7 acetyltransferase C6Y56_RS17280 ENOG4108W2Y isochorismatase C6Y56_RS17295 ENOG4107VIJ nudix hydrolase C6Y56_RS17300 ENOG4105E03 chitinase C6Y56_RS17315 ENOG4105VEV -acetyltransferase C6Y56_RS17335 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) C6Y56_RS17340 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) C6Y56_RS17355 ENOG4107QYG anthranilate phosphoribosyltransferase C6Y56_RS17360 ENOG4105CHF Glutathione S-transferase C6Y56_RS17365 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C6Y56_RS17370 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C6Y56_RS17375 ENOG4108600 CrcB-like protein C6Y56_RS17380 ENOG4105D1H recombination factor protein RarA C6Y56_RS17385 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) C6Y56_RS17390 ENOG4105CNU cell division protein FtsK C6Y56_RS17395 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) C6Y56_RS17400 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate C6Y56_RS17405 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C6Y56_RS17410 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C6Y56_RS17415 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C6Y56_RS17420 ENOG4105VEQ Cold shock protein C6Y56_RS17430 ENOG4105E9K Isocitrate dehydrogenase C6Y56_RS17440 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C6Y56_RS17445 ENOG41075W9 High frequency lysogenization protein HflD homolog C6Y56_RS17450 ENOG4107QTF adenylosuccinate lyase C6Y56_RS17455 ENOG4105EZE Cupin 4 family protein C6Y56_RS17460 ENOG41082BV acetyltransferase C6Y56_RS17470 ENOG4108I9X Isocitrate lyase C6Y56_RS17475 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C6Y56_RS17480 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C6Y56_RS17485 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C6Y56_RS17490 ENOG4105GKE subunit e C6Y56_RS17495 ENOG4107QIZ NADH dehydrogenase C6Y56_RS17500 ENOG4108IEH NADH dehydrogenase subunit g C6Y56_RS17505 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C6Y56_RS17510 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C6Y56_RS17515 ENOG4107UFS subunit j C6Y56_RS17520 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C6Y56_RS17525 ENOG4105D65 subunit l C6Y56_RS17530 ENOG4105C8S subunit m C6Y56_RS17535 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C6Y56_RS17540 ENOG4105J5J Outer membrane porin C6Y56_RS17615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS17620 ENOG4108IJ9 (ABC) transporter C6Y56_RS17625 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C6Y56_RS17630 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C6Y56_RS17635 ENOG4105C8N cysteinyl-tRNA synthetase C6Y56_RS17640 ENOG4105CX6 glutaminyL-tRNA synthetase C6Y56_RS17650 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) C6Y56_RS17655 ENOG4105C0R drug resistance transporter emrb qaca subfamily C6Y56_RS17660 ENOG4105CW7 secretion protein, HlyD family C6Y56_RS17670 ENOG4108ZT1 Transcriptional regulator C6Y56_RS17675 ENOG4105MA0 exported protein C6Y56_RS17680 ENOG4105CFU surface antigen C6Y56_RS17690 ENOG4105CGK Exodeoxyribonuclease III C6Y56_RS17695 ENOG4107QKZ Ompa motb domain protein C6Y56_RS17700 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS17710 ENOG4108Z6Z Transcriptional regulator C6Y56_RS17715 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C6Y56_RS17720 ENOG4105CEY Amp-dependent synthetase and ligase C6Y56_RS17725 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS17730 ENOG4107QX3 carboxylase C6Y56_RS17735 ENOG4105CGU Enoyl-CoA hydratase C6Y56_RS17745 ENOG4105RDA repressor C6Y56_RS17770 ENOG4105CPW cytochrome b561 C6Y56_RS17795 ENOG4105EMN RNA polymerase sigma factor C6Y56_RS17815 ENOG4106P2F Pfam:Pili_assembly_C C6Y56_RS17840 ENOG4105D6Z AFG1 family ATPase C6Y56_RS17845 ENOG4107TPY serine threonine protein kinase C6Y56_RS17855 ENOG4105CS6 Rhs element vgr protein C6Y56_RS17860 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS17865 ENOG4105DJB Major Facilitator Superfamily C6Y56_RS17880 ENOG4107STF Involved in phosphonate degradation (By similarity) C6Y56_RS17885 ENOG4108KAZ Involved in phosphonate degradation (By similarity) C6Y56_RS17900 ENOG4105CPW cytochrome b561 C6Y56_RS17910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS17920 ENOG4108ZX5 transcriptional regulator C6Y56_RS17930 ENOG4105EIN peptidylprolyl cis-trans isomerase C6Y56_RS17935 ENOG4105K70 DNA-binding protein C6Y56_RS17940 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C6Y56_RS17945 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C6Y56_RS17950 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C6Y56_RS17955 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C6Y56_RS17980 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C6Y56_RS17985 ENOG41061WM D-Alanyl-D-Alanine C6Y56_RS18005 ENOG4105EE5 Membrane protein terC C6Y56_RS18015 ENOG41063Z6 transcriptional regulator, lysR family C6Y56_RS18025 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) C6Y56_RS18035 ENOG4108YXG UPF0502 protein C6Y56_RS18045 ENOG4105F9E Shikimate 5-dehydrogenase C6Y56_RS18065 ENOG4108REF Sporulation integral membrane protein ytvi C6Y56_RS18070 ENOG4105CFP Peptidase U32 C6Y56_RS18080 ENOG4107Y9U Membrane C6Y56_RS18085 ENOG4105CMD Transcriptional regulator, GntR family C6Y56_RS18100 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS18125 ENOG4107TSN permease C6Y56_RS18135 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C6Y56_RS18195 ENOG4108WC9 type VI secretion system effector, hcp1 family C6Y56_RS18200 ENOG4105CV8 reductase C6Y56_RS18210 ENOG4105CQ2 DNA polymerase C6Y56_RS18215 ENOG41080XP Cbs domain C6Y56_RS18225 ENOG4105WQ5 TonB family C6Y56_RS18235 ENOG4105SG9 biopolymer transport protein, ExbD C6Y56_RS18245 ENOG4105E43 Extracellular solute-binding protein, family 5 C6Y56_RS18250 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C6Y56_RS18255 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C6Y56_RS18260 ENOG4108JQ5 ABC transporter C6Y56_RS18270 ENOG4105WH9 RNA polymerase C6Y56_RS18285 ENOG4107QS8 (LipO)protein C6Y56_RS18310 ENOG4105D06 uba thif-type nad fad binding protein C6Y56_RS18320 ENOG4105D52 delta-aminolevulinic acid dehydratase C6Y56_RS18325 ENOG4105CYM Glutathione S-transferase C6Y56_RS18335 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) C6Y56_RS18340 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) C6Y56_RS18355 ENOG4105DRB nucleoside-specific channel-forming protein C6Y56_RS18365 ENOG4105CPQ Dehydrogenase C6Y56_RS18405 ENOG4105EXG Transcriptional regulator C6Y56_RS18415 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS18420 ENOG4105D3Y Na H antiporter C6Y56_RS18425 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS18430 ENOG4105IFJ Histidine kinase C6Y56_RS18435 ENOG4105XJC Two component transcriptional regulator (Winged helix family C6Y56_RS18455 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase C6Y56_RS18465 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin C6Y56_RS18470 ENOG4105DZC cytosine deaminase C6Y56_RS18480 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C6Y56_RS18485 ENOG4106UW1 Major Facilitator superfamily C6Y56_RS18495 ENOG4105GAV receptor C6Y56_RS18505 ENOG4108SF5 RNA Polymerase C6Y56_RS18550 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C6Y56_RS18555 ENOG4108SF5 RNA Polymerase C6Y56_RS18560 ENOG4108S3W Anti-feci sigma factor, fecr C6Y56_RS18585 ENOG4107NQ8 LysR family Transcriptional regulator C6Y56_RS18610 ENOG4105E3B Multicopper oxidase C6Y56_RS18630 ENOG4105F87 Dehydratase C6Y56_RS18700 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C6Y56_RS18725 ENOG4105NVB glycoside hydrolase, family 19 C6Y56_RS18830 ENOG4105D07 Signal peptide peptidase, SppA C6Y56_RS18890 ENOG4105RDA repressor C6Y56_RS18950 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C6Y56_RS18960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C6Y56_RS18975 ENOG4105D3Q Sugar transferase C6Y56_RS18980 ENOG4105E3R (LipO)protein C6Y56_RS18995 ENOG4105DAY polysaccharide export protein C6Y56_RS19005 ENOG4105CMR udp-glucose 4-epimerase C6Y56_RS19010 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C6Y56_RS19050 ENOG4105D75 Capsular exopolysaccharide family C6Y56_RS19055 ENOG4105KJF protein tyrosine phosphatase C6Y56_RS19065 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C6Y56_RS19075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS19095 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C6Y56_RS19115 ENOG4105D60 lipoprotein releasing system transmembrane protein C6Y56_RS19120 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C6Y56_RS19125 ENOG4105D60 lipoprotein releasing system transmembrane protein C6Y56_RS19135 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C6Y56_RS19140 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) C6Y56_RS19145 ENOG4105CJ2 (LipO)protein C6Y56_RS19160 ENOG4108JA2 transcriptioN-repair coupling factor C6Y56_RS19170 ENOG4105C0D helicase C6Y56_RS19175 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) C6Y56_RS19195 ENOG4106AIJ Cell Division C6Y56_RS19210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C6Y56_RS19220 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS19225 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C6Y56_RS19235 ENOG41081QV Universal stress protein C6Y56_RS19240 ENOG4105C5H ABC transporter C6Y56_RS19245 ENOG4107SC1 transglycosylase C6Y56_RS19250 ENOG4105BZ1 (ABC) transporter C6Y56_RS19260 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) C6Y56_RS19265 ENOG4107QI1 Mate efflux family protein C6Y56_RS19270 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C6Y56_RS19275 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) C6Y56_RS19280 ENOG4107QM5 aconitate hydratase C6Y56_RS19295 ENOG41065RQ ADP-ribosylation crystallin J1 C6Y56_RS19310 ENOG4105J9X quinohemoprotein amine dehydrogenase gamma subunit C6Y56_RS19350 ENOG4105BZ1 (ABC) transporter C6Y56_RS19365 ENOG4105CE7 Amidase, hydantoinase carbamoylase family C6Y56_RS19370 ENOG4105CSH Transporter C6Y56_RS19375 ENOG4106NZI LysR family Transcriptional regulator C6Y56_RS19380 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase C6Y56_RS19385 ENOG4105MP9 class II Aldolase C6Y56_RS19390 ENOG4105CSH Transporter C6Y56_RS19395 ENOG4105DND Transcriptional regulator C6Y56_RS19400 ENOG4105CJN penicillin-binding protein C6Y56_RS19445 ENOG4108BAS reductase C6Y56_RS19460 ENOG4105CC0 LysR family Transcriptional regulator C6Y56_RS19470 ENOG4105C3J Cysteine desulfurase C6Y56_RS19485 ENOG4108UZX fmn reductase C6Y56_RS19490 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C6Y56_RS19495 ENOG4107T8P acyl-Coa dehydrogenase C6Y56_RS19500 ENOG4107SM7 Transcriptional regulator C6Y56_RS19510 ENOG4108Z4X TRANSCRIPTIONal C6Y56_RS19520 ENOG4105EBM Alpha Beta Hydrolase Fold protein C6Y56_RS19550 ENOG4105FDK ABC transporter C6Y56_RS19580 ENOG4105DHQ Histidine kinase C6Y56_RS19585 ENOG4105XJC Two component transcriptional regulator (Winged helix family C6Y56_RS19595 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C6Y56_RS19600 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase C6Y56_RS19610 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C6Y56_RS19635 ENOG4108RZE Tetr family transcriptional regulator C6Y56_RS19650 ENOG4107QX3 carboxylase C6Y56_RS19655 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS19660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C6Y56_RS19675 ENOG4105NBK UPF0345 protein C6Y56_RS19695 ENOG4105BZU Histidine kinase C6Y56_RS19700 ENOG4105WH1 Two component transcriptional regulator luxr family C6Y56_RS19705 ENOG4107TE5 Lipid kinase C6Y56_RS19715 ENOG4105CVM Molybdenum cofactor synthesis domain protein C6Y56_RS19720 ENOG4108RIR Molybdenum cofactor biosynthesis protein C6Y56_RS19725 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C6Y56_RS19735 ENOG4105D3G Pseudouridine synthase C6Y56_RS19785 ENOG4108WQH regulatoR C6Y56_RS19790 ENOG4105BZU Histidine kinase C6Y56_RS19795 ENOG4105DHT Metal Dependent Phosphohydrolase C6Y56_RS19800 ENOG4108ZGC gaf domain protein C6Y56_RS19810 ENOG4105BZU Histidine kinase C6Y56_RS19815 ENOG4105K56 Transcriptional regulator C6Y56_RS19820 ENOG4108V06 Glutathione peroxidase C6Y56_RS19825 ENOG4105E0X reductase C6Y56_RS19830 ENOG4105CHM Aminotransferase C6Y56_RS19835 ENOG4105D0M Protease HtpX homolog C6Y56_RS19840 ENOG4105FQ6 thiopurine methyltransferase C6Y56_RS19845 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C6Y56_RS19865 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase C6Y56_RS19870 ENOG4105T0Z Conserved Protein C6Y56_RS19890 ENOG4105HEI LysR family (Transcriptional regulator C6Y56_RS19895 ENOG4105K56 Transcriptional regulator C6Y56_RS19900 ENOG4108ZHJ Organic hydroperoxide resistance protein C6Y56_RS19910 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C6Y56_RS19925 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C6Y56_RS19930 ENOG4107R11 Transcriptional regulator C6Y56_RS19945 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C6Y56_RS19960 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C6Y56_RS19975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C6Y56_RS19985 ENOG4108UJV acyl-CoA thioesterase i C6Y56_RS19990 ENOG4108I0Y (ABC) transporter C6Y56_RS19995 ENOG4105CV6 ABC transporter, permease C6Y56_RS20000 ENOG4108RRZ Transcription elongation factor GreB C6Y56_RS20010 ENOG4108VGI doxx family C6Y56_RS20015 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C6Y56_RS20020 ENOG4105F8V Hydrolase, tatD family C6Y56_RS20060 ENOG4105C08 Histidine kinase C6Y56_RS20065 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) C6Y56_RS20070 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C6Y56_RS20075 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C6Y56_RS20105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C6Y56_RS20110 ENOG4105EMU Dehydrogenase C6Y56_RS20115 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein C6Y56_RS20135 ENOG4105ESV Glycosyl transferase, family 4 C6Y56_RS20150 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C6Y56_RS20165 ENOG4108KMV Glycosyl transferase (Group 1 C6Y56_RS20180 ENOG4105K64 Glycosyl transferase, family 2 C6Y56_RS20190 ENOG4105EY8 ABC transporter C6Y56_RS20195 ENOG4105MFV ABC-2 type transporter C6Y56_RS20200 ENOG4108RT7 Glycosyl transferase, family 2 C6Y56_RS20205 ENOG4108RT7 Glycosyl transferase, family 2 C6Y56_RS20215 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C6Y56_RS20220 ENOG4105C1B dTDP-glucose 4-6-dehydratase C6Y56_RS20230 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C6Y56_RS20240 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C6Y56_RS20245 ENOG4105CAT Cytidine monophosphate kinase C6Y56_RS20250 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C6Y56_RS20255 ENOG4105CIH Imidazole acetol-phosphate transaminase C6Y56_RS20260 ENOG4105CQC Prephenate dehydratase C6Y56_RS20265 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C6Y56_RS20270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C6Y56_RS20275 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C6Y56_RS20280 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C6Y56_RS20285 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C6Y56_RS20290 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C6Y56_RS20295 ENOG4105UBK short-chain dehydrogenase reductase C6Y56_RS20300 ENOG4105BZU Histidine kinase C6Y56_RS20310 ENOG4105BZU Histidine kinase C6Y56_RS20330 ENOG4105C72 UPF0176 protein C6Y56_RS20335 ENOG4105M85 Bola protein C6Y56_RS20345 ENOG4105C9Q fumarate hydratase class II C6Y56_RS20350 ENOG4105QYV Membrane C6Y56_RS20360 ENOG4105CHU acetyl-coa acetyltransferase C6Y56_RS20365 ENOG4105CSR polyphosphate kinase 2 C6Y56_RS20370 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) C6Y56_RS20380 ENOG4105CAQ asparagine synthetase C6Y56_RS20395 ENOG4106851 UPF0270 protein C6Y56_RS20400 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C6Y56_RS20405 ENOG4105KK4 UPF0060 membrane protein C6Y56_RS20420 ENOG4105E0M Sulfatase C6Y56_RS20425 ENOG4105VV6 START domain-containing protein C6Y56_RS20440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C6Y56_RS20445 ENOG4108ZG0 Ompa motb domain protein C6Y56_RS20460 ENOG4105C10 Electron transfer flavoprotein C6Y56_RS20465 ENOG4105BZJ Electron transfer flavoprotein C6Y56_RS20470 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase C6Y56_RS20475 ENOG4105CF7 AraC family transcriptional regulator C6Y56_RS20480 ENOG4105DQ4 alcohol dehydrogenase C6Y56_RS20485 ENOG4107HP6 Transcriptional regulator C6Y56_RS20490 ENOG4105DJB Major Facilitator Superfamily C6Y56_RS20495 ENOG4105CXK mandelate racemase muconate lactonizing C6Y56_RS20500 ENOG4108RTU Aldolase C6Y56_RS20505 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 C6Y56_RS20530 ENOG4108RVA ribokinase C6Y56_RS20540 ENOG4108KD5 ADP-ribosylation crystallin J1 C6Y56_RS20545 ENOG4105FDP GntR family transcriptional regulator C6Y56_RS20550 ENOG4105CNN ABC, transporter C6Y56_RS20555 ENOG4105C2J ABC transporter C6Y56_RS20560 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator C6Y56_RS20565 ENOG4108R85 Short chain dehydrogenase C6Y56_RS20575 ENOG4107EJG GntR family transcriptional regulator C6Y56_RS20590 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C6Y56_RS20600 ENOG4105F8V Hydrolase, tatD family C6Y56_RS20610 ENOG4107QRG dna polymerase iii C6Y56_RS20615 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C6Y56_RS20620 ENOG4105HHA aminodeoxychorismate lyase C6Y56_RS20630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C6Y56_RS20640 ENOG4105CHR reductase C6Y56_RS20645 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C6Y56_RS20650 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C6Y56_RS20655 ENOG4105VGS 50s ribosomal protein l32 C6Y56_RS20660 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein C6Y56_RS20665 ENOG4108UHJ MAF-like protein C6Y56_RS20670 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C6Y56_RS20680 ENOG4105EI2 Pseudouridine synthase C6Y56_RS20685 ENOG4107QQB Ribonuclease E C6Y56_RS20695 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family C6Y56_RS20710 ENOG4105D4A Cell wall formation (By similarity) C6Y56_RS20720 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) C6Y56_RS20725 ENOG4105W49 UPF0434 protein C6Y56_RS20730 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C6Y56_RS20735 ENOG4109015 Biopolymer transport protein exbD tolR C6Y56_RS20745 ENOG4108EC8 DNA internalization-related competence protein ComEC C6Y56_RS20755 ENOG4105E3A (ABC) transporter C6Y56_RS20760 ENOG4105DA5 (ABC) transporter C6Y56_RS20765 ENOG4108TGY Glutathione S-transferase C6Y56_RS20775 ENOG4107QPN acyl-Coa dehydrogenase C6Y56_RS20785 ENOG4105EXG Transcriptional regulator C6Y56_RS20790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C6Y56_RS20800 ENOG4108NIW Leucine export protein LeuE C6Y56_RS20845 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS20850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C6Y56_RS20855 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C6Y56_RS20860 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C6Y56_RS20865 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C6Y56_RS20875 ENOG4105E0F Histidine kinase C6Y56_RS20885 ENOG4105IPI Membrane C6Y56_RS20905 ENOG4105KA0 thioesterase Superfamily protein C6Y56_RS20910 ENOG4108IQE Amp-dependent synthetase and ligase C6Y56_RS20925 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C6Y56_RS20930 ENOG4107RNH Outer membrane receptor FepA C6Y56_RS20940 ENOG4105BZU Histidine kinase C6Y56_RS20945 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) C6Y56_RS20960 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme C6Y56_RS20965 ENOG4105DXN mazG family C6Y56_RS20970 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C6Y56_RS20975 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C6Y56_RS20980 ENOG4105C6T cysteine synthase C6Y56_RS20985 ENOG410804D Sensor Signal Transduction Histidine Kinase C6Y56_RS20995 ENOG4105BZU Histidine kinase C6Y56_RS21000 ENOG4105C5I Dehydrogenase C6Y56_RS21025 ENOG4105K89 arsenate reductase C6Y56_RS21030 ENOG4105CS1 NAD(P)H quinone oxidoreductase C6Y56_RS21040 ENOG4108R3E Dna-3-methyladenine glycosylase i C6Y56_RS21045 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C6Y56_RS21050 ENOG41069YE inner membrane protein yohC C6Y56_RS21055 ENOG4105GPY SprT protein C6Y56_RS21060 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C6Y56_RS21065 ENOG4105CK2 sodium dicarboxylate symporter C6Y56_RS21070 ENOG4105ID8 Transcriptional regulator, ARAC family C6Y56_RS21075 ENOG4105IFJ Histidine kinase C6Y56_RS21080 ENOG4105XJC Two component transcriptional regulator (Winged helix family C6Y56_RS21095 ENOG4105JJR Histidine kinase C6Y56_RS21100 ENOG4107EXC regulatoR C6Y56_RS21105 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C6Y56_RS21110 ENOG4105BZE flagellar hook protein, FlgE C6Y56_RS21115 ENOG410822I Flagellar hook capping protein C6Y56_RS21120 ENOG4108ZC9 flagellar basal-body rod protein flgc C6Y56_RS21125 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C6Y56_RS21130 ENOG4105BZU Histidine kinase C6Y56_RS21135 ENOG4107R88 Chemotaxis protein (CheV) C6Y56_RS21155 ENOG4106825 Type iv pilus assembly C6Y56_RS21160 ENOG4108ISG Major Facilitator C6Y56_RS21185 ENOG4108KU3 Integrase C6Y56_RS21330 ENOG4105CJW magnesium transporter C6Y56_RS21365 ENOG4105CFH Aspartokinase C6Y56_RS21370 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C6Y56_RS21375 ENOG4105C5W Aldolase C6Y56_RS21380 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C6Y56_RS21385 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) C6Y56_RS21395 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) C6Y56_RS21400 ENOG4105C26 Dehydrogenase C6Y56_RS21405 ENOG4105F4X arginine C6Y56_RS21410 ENOG4108T2Z Arginine C6Y56_RS21415 ENOG4105C8Y Acetylornithine aminotransferase C6Y56_RS21425 ENOG4105ECQ AraC Family Transcriptional Regulator C6Y56_RS21430 ENOG4108JEH abc transporter atp-binding protein C6Y56_RS21445 ENOG4105DSP amino acid AbC transporter C6Y56_RS21450 ENOG4105E89 ABC transporter C6Y56_RS21455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C6Y56_RS21465 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C6Y56_RS21495 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C6Y56_RS21510 ENOG410630P Transcriptional regulator C6Y56_RS21515 ENOG4105BZU Histidine kinase C6Y56_RS21520 ENOG4107SDU Methyl-accepting chemotaxis C6Y56_RS21535 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C6Y56_RS21540 ENOG4105KAC Antibiotic biosynthesis monooxygenase C6Y56_RS21550 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C6Y56_RS21565 ENOG4108NVR Methyl-accepting chemotaxis C6Y56_RS21575 ENOG4105CJ3 phosphate transporter C6Y56_RS21580 ENOG4105CBN LysR family transcriptional regulator C6Y56_RS21585 ENOG4105CHR reductase C6Y56_RS21595 ENOG410810E transcriptional regulator, lysR family C6Y56_RS21600 ENOG4105CN8 Transcriptional regulator C6Y56_RS21605 ENOG4105EMU Dehydrogenase C6Y56_RS21610 ENOG4105CHP RNA polymerase C6Y56_RS21615 ENOG4105GRZ Ycii-related protein C6Y56_RS21625 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C6Y56_RS21660 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C6Y56_RS21680 ENOG4105CHM Aminotransferase C6Y56_RS21685 ENOG4105C6Z Gluconate C6Y56_RS21690 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family C6Y56_RS21695 ENOG4105DIQ Transcriptional regulator C6Y56_RS21700 ENOG4105C5Q Transcriptional regulator C6Y56_RS21710 ENOG4105C54 Major Facilitator superfamily C6Y56_RS21720 ENOG4107SDU Methyl-accepting chemotaxis C6Y56_RS21750 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C6Y56_RS21755 ENOG4107U9T Pfam:Ribonuclease_BN C6Y56_RS21770 ENOG4105CEY Amp-dependent synthetase and ligase C6Y56_RS21775 ENOG4105CEY Amp-dependent synthetase and ligase C6Y56_RS21785 ENOG4108F01 MaoC domain protein C6Y56_RS21795 ENOG4105VRT cytoplasmic protein C6Y56_RS21810 ENOG4108UHU Aldolase C6Y56_RS21815 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) C6Y56_RS21820 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C6Y56_RS21825 ENOG4106KNT transcriptional regulator C6Y56_RS21830 ENOG4105DSB aldose 1-epimerase C6Y56_RS21835 ENOG4105TW1 Carbohydrate-selective porin OprB C6Y56_RS21840 ENOG4108IJ9 (ABC) transporter C6Y56_RS21845 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component C6Y56_RS21855 ENOG4108JP0 extracellular solute-binding protein family 1 C6Y56_RS21860 ENOG4107QKS N-acylglucosamine 2-epimerase C6Y56_RS21865 ENOG4105E0F Histidine kinase C6Y56_RS21880 ENOG4105C01 Dihydroxy-acid dehydratase C6Y56_RS21885 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C6Y56_RS21895 ENOG4108S3W Anti-feci sigma factor, fecr C6Y56_RS21900 ENOG4107ENK receptor C6Y56_RS21905 ENOG4108YNN Heme oxygenase C6Y56_RS21910 ENOG4105WD1 Membrane C6Y56_RS21915 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS21925 ENOG4105D5Q Arginine ornithine antiporter C6Y56_RS21930 ENOG4105D5Q Arginine ornithine antiporter C6Y56_RS21935 ENOG4105CEU Arginine dihydrolase C6Y56_RS21940 ENOG4105DBV ornithine carbamoyltransferase C6Y56_RS21945 ENOG4105C5B carbamate kinase C6Y56_RS21960 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C6Y56_RS21965 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C6Y56_RS21970 ENOG4105EJQ L-serine dehydratase C6Y56_RS21975 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C6Y56_RS21990 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C6Y56_RS22005 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C6Y56_RS22010 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C6Y56_RS22015 ENOG4105UFD tol-pal system protein YbgF C6Y56_RS22020 ENOG4105KCK Peptidoglycan-associated lipoprotein C6Y56_RS22025 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) C6Y56_RS22035 ENOG4105M8F Biopolymer transport protein exbD tolR C6Y56_RS22040 ENOG4105E02 MotA TolQ exbB proton channel C6Y56_RS22045 ENOG4107YD3 Thioesterase C6Y56_RS22050 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C6Y56_RS22055 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C6Y56_RS22060 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C6Y56_RS22065 ENOG4105CDY transcriptional regulatory protein C6Y56_RS22070 ENOG4105C9M aspartyl-trna synthetase C6Y56_RS22090 ENOG4105VEQ Cold shock protein C6Y56_RS22095 ENOG41069P5 Protein slyX homolog C6Y56_RS22105 ENOG4105J5J Outer membrane porin C6Y56_RS22110 ENOG4105D64 Mechanosensitive ion channel C6Y56_RS22115 ENOG4108VPT UPF0234 protein C6Y56_RS22120 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C6Y56_RS22130 ENOG4108WBT adenosyltransferase C6Y56_RS22135 ENOG4105M6F mutator MutT protein C6Y56_RS22145 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C6Y56_RS22150 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C6Y56_RS22160 ENOG4105D7A ATP-binding protein C6Y56_RS22165 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS22170 ENOG4105BZF Glycosyl transferase (Group 1 C6Y56_RS22200 ENOG4105CJB Exodeoxyribonuclease I C6Y56_RS22225 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C6Y56_RS22255 ENOG4105CA9 Pyruvate kinase C6Y56_RS22260 ENOG4105E39 Enoyl-CoA hydratase C6Y56_RS22270 ENOG4105BZU Histidine kinase C6Y56_RS22275 ENOG4107GFK fumarate C6Y56_RS22285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS22290 ENOG4105CSH Transporter C6Y56_RS22315 ENOG4105CF7 AraC family transcriptional regulator C6Y56_RS22320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS22330 ENOG4108I5D sulfate abc transporter C6Y56_RS22345 ENOG4105C7K acetolactate synthase C6Y56_RS22350 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS22355 ENOG4108RYK Nad-dependent epimerase dehydratase C6Y56_RS22365 ENOG4105EJC lysr family transcriptional regulator C6Y56_RS22380 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase C6Y56_RS22385 ENOG4105C0R drug resistance transporter emrb qaca subfamily C6Y56_RS22400 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C6Y56_RS22405 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C6Y56_RS22415 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C6Y56_RS22420 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C6Y56_RS22425 ENOG4105BZU Histidine kinase C6Y56_RS22450 ENOG4105ENT Efflux transporter rnd family, mfp subunit C6Y56_RS22455 ENOG4105BZS acriflavin resistance protein C6Y56_RS22465 ENOG4105FQR PH-inducible protein involved in stress response C6Y56_RS22475 ENOG4105DHQ Histidine kinase C6Y56_RS22485 ENOG4105E0M Sulfatase C6Y56_RS22495 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C6Y56_RS22500 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C6Y56_RS22515 ENOG4105CHR reductase C6Y56_RS22525 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C6Y56_RS22535 ENOG4108R3D Electron transport complex C6Y56_RS22540 ENOG4105D6A Electron transport complex C6Y56_RS22545 ENOG4108UQQ Electron transport complex C6Y56_RS22555 ENOG4105CSM endonuclease III C6Y56_RS22565 ENOG4108WQH regulatoR C6Y56_RS22575 ENOG4105CDH Citrulline--aspartate ligase C6Y56_RS22585 ENOG4105EKE dihydroorotase C6Y56_RS22590 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) C6Y56_RS22595 ENOG4105D3R alkyl hydroperoxide reductase C6Y56_RS22600 ENOG4105W53 bacterioferritin-associated ferredoxin C6Y56_RS22605 ENOG4108UQY Iron-storage protein C6Y56_RS22610 ENOG4105M2J Glutaredoxin C6Y56_RS22615 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C6Y56_RS22625 ENOG4105DBV ornithine carbamoyltransferase C6Y56_RS22630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS22635 ENOG4105JAB phenazine biosynthesis protein, phzf family C6Y56_RS22640 ENOG4108Z66 YbaK ebsC protein C6Y56_RS22645 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C6Y56_RS22650 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C6Y56_RS22655 ENOG4105E98 transcriptional regulator DeoR family C6Y56_RS22665 ENOG4107RP9 extracellular solute-binding protein, family 3 C6Y56_RS22670 ENOG4105EAD ABC transporter C6Y56_RS22675 ENOG4105DRP amino acid AbC transporter C6Y56_RS22680 ENOG4105CDA abc transporter atp-binding protein C6Y56_RS22685 ENOG4105CQZ Histidine kinase C6Y56_RS22690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS22695 ENOG4105RA2 Membrane C6Y56_RS22710 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) C6Y56_RS22725 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C6Y56_RS22730 ENOG4105C8Y Acetylornithine aminotransferase C6Y56_RS22745 ENOG4105BZU Histidine kinase C6Y56_RS22750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS22755 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C6Y56_RS22765 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C6Y56_RS22770 ENOG4105DZ2 Transcriptional regulator C6Y56_RS22780 ENOG410829K Lysine exporter protein (Lyse ygga) C6Y56_RS22785 ENOG4105M6F mutator MutT protein C6Y56_RS22790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS22795 ENOG4105BZU Histidine kinase C6Y56_RS22800 ENOG4105BZU Histidine kinase C6Y56_RS22805 ENOG4105CA0 peroxidase C6Y56_RS22820 ENOG4105CUB amino acid C6Y56_RS22830 ENOG4105WH1 Two component transcriptional regulator luxr family C6Y56_RS22835 ENOG4105CBC glutamate synthase C6Y56_RS22845 ENOG4105C85 amino acid C6Y56_RS22890 ENOG4105NTW Transcriptional regulator C6Y56_RS22895 ENOG4105Q26 Siderophore-interacting protein C6Y56_RS22905 ENOG4105VYA Uncharacterized conserved protein (DUF2132) C6Y56_RS22910 ENOG4105TW1 Carbohydrate-selective porin OprB C6Y56_RS22915 ENOG4105DZG Dehydrogenase C6Y56_RS22925 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C6Y56_RS22945 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) C6Y56_RS22950 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) C6Y56_RS22955 ENOG4108Z6B deaminase C6Y56_RS22970 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C6Y56_RS22980 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C6Y56_RS22985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C6Y56_RS23005 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C6Y56_RS23010 ENOG4105DR5 peptidase C6Y56_RS23015 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C6Y56_RS23020 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C6Y56_RS23025 ENOG4105CHM Aminotransferase C6Y56_RS23035 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C6Y56_RS23040 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C6Y56_RS23050 ENOG4105CUT histidyl-tRNA synthetase C6Y56_RS23055 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C6Y56_RS23060 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) C6Y56_RS23070 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C6Y56_RS23075 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C6Y56_RS23080 ENOG4105WVQ Fe-S assembly protein IscX C6Y56_RS23085 ENOG4108ZIT Ferredoxin, 2FE-2S C6Y56_RS23090 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB C6Y56_RS23095 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) C6Y56_RS23100 ENOG4108Z4V iron-sulfur cluster assembly C6Y56_RS23105 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins C6Y56_RS23110 ENOG4105C3J Cysteine desulfurase C6Y56_RS23115 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C6Y56_RS23130 ENOG4105ECY inositol monophosphatase C6Y56_RS23135 ENOG4107MBR 17 kDa surface antigen C6Y56_RS23140 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C6Y56_RS23145 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C6Y56_RS23150 ENOG4105VIE preprotein translocase, subunit YajC C6Y56_RS23155 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C6Y56_RS23160 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C6Y56_RS23265 ENOG4105C8Y Acetylornithine aminotransferase C6Y56_RS23270 ENOG4105HEI LysR family (Transcriptional regulator C6Y56_RS23275 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C6Y56_RS23290 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C6Y56_RS23300 ENOG4105E0X reductase C6Y56_RS23305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C6Y56_RS23320 ENOG4107Z36 nucleotidyl transferase C6Y56_RS23325 ENOG41082DT Glutamine amido-transferase C6Y56_RS23330 ENOG4105P12 pyruvate phosphate dikinase C6Y56_RS23340 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C6Y56_RS23350 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C6Y56_RS23370 ENOG4105CM2 brancheD-chain amino acid aminotransferase C6Y56_RS23375 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C6Y56_RS23380 ENOG4108SHQ Glutathione S-transferase C6Y56_RS23405 ENOG4105C6F GntR Family Transcriptional Regulator C6Y56_RS23410 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C6Y56_RS23415 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) C6Y56_RS23420 ENOG4105CCU oxidase (Subunit III) C6Y56_RS23425 ENOG4105BZ9 Cytochrome C oxidase, subunit I C6Y56_RS23430 ENOG4105E2S oxidase) subunit II C6Y56_RS23435 ENOG4105RXK Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C6Y56_RS23445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C6Y56_RS23475 ENOG4108NVR Methyl-accepting chemotaxis C6Y56_RS23495 ENOG4105BZS acriflavin resistance protein C6Y56_RS23505 ENOG4105GR3 Histidine kinase C6Y56_RS23515 ENOG4105J5J Outer membrane porin C6Y56_RS23525 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C6Y56_RS23530 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C6Y56_RS23535 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C6Y56_RS23540 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) C6Y56_RS23545 ENOG4105CPF Cell wall formation (By similarity) C6Y56_RS23550 ENOG4105DFU Cell wall formation (By similarity) C6Y56_RS23555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C6Y56_RS23560 ENOG4105CNI cell division protein FtsW C6Y56_RS23565 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C6Y56_RS23570 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C6Y56_RS23575 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) C6Y56_RS23580 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C6Y56_RS23585 ENOG4105CJN penicillin-binding protein C6Y56_RS23595 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C6Y56_RS23600 ENOG4108V6E Cell division protein mraZ C6Y56_RS23610 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C6Y56_RS23620 ENOG41082RQ UPF0102 protein C6Y56_RS23625 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C6Y56_RS23630 ENOG4105W4M Transport-associated protein C6Y56_RS23635 ENOG4105KB2 stringent starvation protein b C6Y56_RS23640 ENOG4107MKT Stringent starvation protein a C6Y56_RS23645 ENOG4105EIX cytochrome c1 C6Y56_RS23650 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C6Y56_RS23655 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C6Y56_RS23660 ENOG4108UJD 30S ribosomal protein S9 C6Y56_RS23665 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C6Y56_RS23670 ENOG4105CPC Aldo Keto reductase C6Y56_RS23675 ENOG4105C1G acyl-Coa dehydrogenase C6Y56_RS23685 ENOG4105D6Z AFG1 family ATPase C6Y56_RS23690 ENOG4105C31 Tryptophanyl-tRNA synthetase C6Y56_RS23705 ENOG4105UYK outer membrane protein a C6Y56_RS23710 ENOG4105C5X domain protein C6Y56_RS23795 ENOG4105D25 secreted protein C6Y56_RS23805 ENOG4105CEY Amp-dependent synthetase and ligase C6Y56_RS23810 ENOG4105DNH Major Facilitator C6Y56_RS23820 ENOG4105CCF Lysine exporter protein (Lyse ygga) C6Y56_RS23825 ENOG4105C5I Dehydrogenase C6Y56_RS23830 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) C6Y56_RS23840 ENOG4108K0D peptidase, M48 C6Y56_RS23845 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS23850 ENOG4108KQ5 Integrase catalytic subunit C6Y56_RS23855 ENOG4108RAV Conserved protein C6Y56_RS23895 ENOG4105DWT malate dehydrogenase (quinone) C6Y56_RS23910 ENOG4108UGV hypoxanthine phosphoribosyltransferase C6Y56_RS23915 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C6Y56_RS23920 ENOG4105C2W permease C6Y56_RS23925 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C6Y56_RS23930 ENOG4105ECP epimerase C6Y56_RS23935 ENOG4108QDE fad dependent oxidoreductase C6Y56_RS23950 ENOG4108XDN Transcriptional regulator C6Y56_RS23955 ENOG4105CVP deoxyribo-dipyrimidine photolyase C6Y56_RS23965 ENOG4105EMU Dehydrogenase C6Y56_RS23980 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C6Y56_RS23995 ENOG41061N2 exported protein C6Y56_RS24000 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C6Y56_RS24005 ENOG4105D06 uba thif-type nad fad binding protein C6Y56_RS24010 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C6Y56_RS24015 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C6Y56_RS24020 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C6Y56_RS24025 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein C6Y56_RS24030 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) C6Y56_RS24035 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C6Y56_RS24045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C6Y56_RS24050 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C6Y56_RS24055 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C6Y56_RS24060 ENOG4105C3G gtp-binding protein C6Y56_RS24065 ENOG4105EU0 Major facilitator Superfamily C6Y56_RS24070 ENOG4108NVR Methyl-accepting chemotaxis C6Y56_RS24085 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C6Y56_RS24090 ENOG4108MEJ flavin reductase domain protein C6Y56_RS24095 ENOG4107SDU Methyl-accepting chemotaxis C6Y56_RS24100 ENOG4105CSH Transporter C6Y56_RS24105 ENOG4105CRW Short chain fatty acid transporter C6Y56_RS24125 ENOG41077A9 carbonic anhydrase C6Y56_RS24135 ENOG4105KEG ribosomal-protein-alanine acetyltransferase C6Y56_RS24160 ENOG4105DY2 Paraquat-inducible protein b C6Y56_RS24165 ENOG4105F1S paraquat-inducible protein a C6Y56_RS24170 ENOG4105F1S paraquat-inducible protein a C6Y56_RS24200 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) C6Y56_RS24205 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C6Y56_RS24210 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C6Y56_RS24215 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C6Y56_RS24220 ENOG4108ZP8 Acetolactate synthase small subunit C6Y56_RS24225 ENOG4105C7K acetolactate synthase C6Y56_RS24235 ENOG4105DR9 pseudouridine synthase C6Y56_RS24245 ENOG4105BZ4 penicillin-binding protein C6Y56_RS24275 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS24280 ENOG4105EHG Permease protein C6Y56_RS24285 ENOG4107R4I Periplasmic binding protein C6Y56_RS24295 ENOG4105PW4 Sugar fermentation stimulation protein homolog C6Y56_RS24310 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) C6Y56_RS24320 ENOG4105BZU Histidine kinase C6Y56_RS24325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS24330 ENOG4105DJ0 Poly(A) Polymerase C6Y56_RS24335 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C6Y56_RS24340 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C6Y56_RS24345 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C6Y56_RS24350 ENOG4107QP8 phosphohexose isomerase C6Y56_RS24355 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C6Y56_RS24360 ENOG4105DR4 Methyltransferase C6Y56_RS24375 ENOG4105W4M Transport-associated protein C6Y56_RS24385 ENOG4107QHF type ii secretion system protein e C6Y56_RS24400 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C6Y56_RS24405 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) C6Y56_RS24440 ENOG4105CEP NADH dehydrogenase C6Y56_RS24475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C6Y56_RS24480 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C6Y56_RS24485 ENOG4105C34 Pseudouridine synthase C6Y56_RS24490 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C6Y56_RS24500 ENOG4107TUY Histidine kinase C6Y56_RS24505 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS24510 ENOG4108DN8 FAD dependent oxidoreductase C6Y56_RS24550 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C6Y56_RS24555 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase C6Y56_RS24560 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C6Y56_RS24565 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C6Y56_RS24570 ENOG4105DTN riboflavin biosynthesis protein ribF C6Y56_RS24575 ENOG4105CJR Integral membrane protein (MviN C6Y56_RS24580 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C6Y56_RS24585 ENOG4108RH0 Crea protein C6Y56_RS24590 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C6Y56_RS24595 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C6Y56_RS24600 ENOG4105K46 50S ribosomal protein l27 C6Y56_RS24605 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C6Y56_RS24610 ENOG4105EAH synthase C6Y56_RS24615 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C6Y56_RS24620 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C6Y56_RS24625 ENOG4108V1T peptidylprolyl cis-trans isomerase C6Y56_RS24635 ENOG4108TEB UPF0114 protein C6Y56_RS24650 ENOG4105DAN ATP-dependent protease C6Y56_RS24670 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C6Y56_RS24675 ENOG4105D82 Glutamate dehydrogenase C6Y56_RS24680 ENOG4105C5H ABC transporter C6Y56_RS24685 ENOG4105BZU Histidine kinase C6Y56_RS24690 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C6Y56_RS24710 ENOG4105CKI cobalamin synthesis protein C6Y56_RS24715 ENOG4105VCD cytoplasmic protein C6Y56_RS24720 ENOG4105D22 carbon starvation protein C6Y56_RS24730 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C6Y56_RS24740 ENOG4105CH6 catalase C6Y56_RS24745 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C6Y56_RS24750 ENOG4105DP0 ferredoxin-NADP reductase C6Y56_RS24755 ENOG4105VJY transcriptional regulator C6Y56_RS24760 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) C6Y56_RS24770 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C6Y56_RS24775 ENOG4105C4M (Ubiquinol oxidase) subunit I C6Y56_RS24805 ENOG4105C7N Xanthine uracil vitamin C permease C6Y56_RS24810 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) C6Y56_RS24825 ENOG410642W LysR family Transcriptional regulator C6Y56_RS24830 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C6Y56_RS24835 ENOG4107S9B Shikimate dehydrogenase C6Y56_RS24840 ENOG4108W9H Tetr family transcriptional regulator C6Y56_RS24850 ENOG4105C0R drug resistance transporter emrb qaca subfamily C6Y56_RS24875 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein C6Y56_RS24880 ENOG4105CV8 reductase C6Y56_RS24885 ENOG4105CGZ zinc metallopeptidase C6Y56_RS24900 ENOG4105C29 acyl-CoA thioesterase C6Y56_RS24905 ENOG4108YYQ gCN5-related N-acetyltransferase C6Y56_RS24910 ENOG4105DGU Histone deacetylase C6Y56_RS24915 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C6Y56_RS24920 ENOG4105C1J atp-dependent rna helicase C6Y56_RS24925 ENOG4105FDR Membrane C6Y56_RS24935 ENOG4105DVT helicase C6Y56_RS24945 ENOG4105G4C Periplasmic ligand-binding sensor protein C6Y56_RS24975 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C6Y56_RS24980 ENOG4105C26 Dehydrogenase C6Y56_RS24995 ENOG4105CQ7 ATP-dependent helicase C6Y56_RS25005 ENOG41076HS cation diffusion facilitator family transporter C6Y56_RS25015 ENOG4108ZRZ Transcriptional regulator (AsnC family) C6Y56_RS25025 ENOG4108R99 pseudouridine synthase C6Y56_RS25030 ENOG4105FYV Amp nucleosidase C6Y56_RS25035 ENOG4105CSU acyl-Coa dehydrogenase C6Y56_RS25040 ENOG4105BZU Histidine kinase C6Y56_RS25050 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C6Y56_RS25055 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C6Y56_RS25070 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C6Y56_RS25075 ENOG4105C9A Phoh family C6Y56_RS25080 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C6Y56_RS25085 ENOG4108JU5 Magnesium and cobalt efflux protein C6Y56_RS25090 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C6Y56_RS25105 ENOG4105C8T Leucyl-tRNA synthetase C6Y56_RS25125 ENOG4105CVE Lytic murein transglycosylase C6Y56_RS25135 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C6Y56_RS25140 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C6Y56_RS25150 ENOG4105DZ1 carboxypeptidase C6Y56_RS25160 ENOG4105CVE Lytic murein transglycosylase C6Y56_RS25165 ENOG4105CNI cell division protein FtsW C6Y56_RS25170 ENOG4105CJN penicillin-binding protein C6Y56_RS25175 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C6Y56_RS25185 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C6Y56_RS25190 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C6Y56_RS25195 ENOG4108RB4 3-methyladenine DNA glycosylase C6Y56_RS25200 ENOG4108KF1 Membrane C6Y56_RS25220 ENOG41067MG lrgb family C6Y56_RS25240 ENOG4105K4T epimerase C6Y56_RS25255 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C6Y56_RS25260 ENOG4105DFU Cell wall formation (By similarity) C6Y56_RS25265 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C6Y56_RS25270 ENOG4105C26 Dehydrogenase C6Y56_RS25280 ENOG4105CPD ethanolamine ammonia-lyase C6Y56_RS25285 ENOG4107FQ9 ethanolamine ammonia-lyase C6Y56_RS25290 ENOG4105KD7 acetyltransferase C6Y56_RS25295 ENOG4105DQR SNARE associated Golgi C6Y56_RS25300 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) C6Y56_RS25305 ENOG4105F0N pyrophosphate phospho-hydrolase C6Y56_RS25310 ENOG4108XTP Transcriptional regulator C6Y56_RS25320 ENOG4105K4U addiction module toxin, RelE StbE family C6Y56_RS25325 ENOG4105EDV vault protein C6Y56_RS25330 ENOG41081SK signal peptide protein C6Y56_RS25335 ENOG4107S52 alpha-2-macroglobulin domain protein C6Y56_RS25340 ENOG4108QJJ Protein of unknown function (DUF1175) C6Y56_RS25345 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) C6Y56_RS25350 ENOG4105EDV vault protein C6Y56_RS25355 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C6Y56_RS25360 ENOG4105CTB Polyprenyl synthetase C6Y56_RS25365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C6Y56_RS25375 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C6Y56_RS25385 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) C6Y56_RS25395 ENOG4108ZAI phosphatidylglycerophosphatase a C6Y56_RS25400 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C6Y56_RS25405 ENOG4107YIM Involved in the transcription termination process (By similarity) C6Y56_RS25410 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C6Y56_RS25415 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C6Y56_RS25425 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C6Y56_RS25430 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C6Y56_RS25440 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C6Y56_RS25445 ENOG4107QR8 Thioredoxin C6Y56_RS25475 ENOG4105EIF outer membrane protein W C6Y56_RS25480 ENOG4105C1B dTDP-glucose 4-6-dehydratase C6Y56_RS25490 ENOG4107QRT dEAD DEAH box helicase C6Y56_RS25495 ENOG4105D8X mechanosensitive ion channel C6Y56_RS25500 ENOG4105F27 Major Facilitator C6Y56_RS25510 ENOG4105X23 Endonuclease Exonuclease phosphatase C6Y56_RS25515 ENOG4105DZQ phospholipase D Transphosphatidylase C6Y56_RS25520 ENOG4107UXM Membrane C6Y56_RS25535 ENOG4105EQD regulatoR C6Y56_RS25540 ENOG4108W2Y isochorismatase C6Y56_RS25545 ENOG4105FUX Conserved Protein C6Y56_RS25550 ENOG4108P9J Phage shock protein A C6Y56_RS25560 ENOG4105Z6B inner membrane protein yjfl C6Y56_RS25570 ENOG4106032 Glutathionylspermidine synthase C6Y56_RS25575 ENOG4108UUM single-stranded DNA-binding protein C6Y56_RS25580 ENOG4107RDB Major Facilitator C6Y56_RS25585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C6Y56_RS25590 ENOG4108UWD Iron-storage protein C6Y56_RS25600 ENOG4108ZT0 50S ribosomal protein l17 C6Y56_RS25605 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C6Y56_RS25610 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C6Y56_RS25615 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C6Y56_RS25620 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C6Y56_RS25630 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C6Y56_RS25635 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C6Y56_RS25640 ENOG4105VPB 50S ribosomal protein L30 C6Y56_RS25645 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C6Y56_RS25650 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C6Y56_RS25655 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C6Y56_RS25660 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C6Y56_RS25665 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C6Y56_RS25670 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C6Y56_RS25675 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C6Y56_RS25680 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C6Y56_RS25685 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C6Y56_RS25690 ENOG41083MP 50s ribosomal protein l29 C6Y56_RS25695 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C6Y56_RS25700 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C6Y56_RS25705 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C6Y56_RS25710 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C6Y56_RS25715 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C6Y56_RS25720 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C6Y56_RS25725 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C6Y56_RS25730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C6Y56_RS25735 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C6Y56_RS25740 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C6Y56_RS25745 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C6Y56_RS25750 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C6Y56_RS25755 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C6Y56_RS25760 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C6Y56_RS25765 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C6Y56_RS25770 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C6Y56_RS25775 ENOG4108VZM 50s ribosomal protein L10 C6Y56_RS25780 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C6Y56_RS25785 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C6Y56_RS25790 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C6Y56_RS25795 ENOG4105PM1 preprotein translocase subunit SecE C6Y56_RS25805 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C6Y56_RS25830 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C6Y56_RS25835 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C6Y56_RS25865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C6Y56_RS25870 ENOG4105DR5 peptidase C6Y56_RS25875 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C6Y56_RS25880 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C6Y56_RS25885 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C6Y56_RS25890 ENOG4108YXA Membrane C6Y56_RS25905 ENOG4105EMU Dehydrogenase C6Y56_RS25910 ENOG4107YU2 histidine triad (hIT) protein C6Y56_RS25915 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) C6Y56_RS25920 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C6Y56_RS25925 ENOG4108UKZ OsmC family C6Y56_RS25930 ENOG4107RYR Transcriptional regulator, Crp Fnr family C6Y56_RS25940 ENOG4105DK0 Indole-3-glycerol phosphate synthase C6Y56_RS25945 ENOG4108I0Q anthranilate phosphoribosyltransferase C6Y56_RS25950 ENOG4105DDQ anthranilate synthase C6Y56_RS25955 ENOG4108FHP Autotransporter beta-domain C6Y56_RS25960 ENOG4105CRQ synthase (Component I) C6Y56_RS25965 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C6Y56_RS25970 ENOG4105DJV ribulose-phosphate 3-epimerase C6Y56_RS25975 ENOG4105C0A alcohol dehydrogenase C6Y56_RS25985 ENOG4105F38 ABC transporter, permease C6Y56_RS25995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS26000 ENOG4105WH1 Two component transcriptional regulator luxr family C6Y56_RS26015 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) C6Y56_RS26020 ENOG4108S0S Nucleotidyl transferase C6Y56_RS26025 ENOG4105EHM Aminoglycoside phosphotransferase C6Y56_RS26030 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) C6Y56_RS26035 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C6Y56_RS26040 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C6Y56_RS26045 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C6Y56_RS26050 ENOG4105NWN ApaG protein C6Y56_RS26055 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C6Y56_RS26060 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) C6Y56_RS26065 ENOG4105CYN Serine protein kinase C6Y56_RS26070 ENOG4106AKX UPF0229 protein C6Y56_RS26075 ENOG4105ED1 spovr family C6Y56_RS26080 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C6Y56_RS26090 ENOG4107ZVW dihydroneopterin aldolase C6Y56_RS26095 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C6Y56_RS26100 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C6Y56_RS26105 ENOG4105VCC 30S ribosomal protein S21 C6Y56_RS26110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C6Y56_RS26120 ENOG4105BZU Histidine kinase C6Y56_RS26155 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) C6Y56_RS26160 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) C6Y56_RS26165 ENOG4106URE pyrroloquinoline quinone biosynthesis protein d C6Y56_RS26170 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C6Y56_RS26195 ENOG4105C8Y Acetylornithine aminotransferase C6Y56_RS26200 ENOG4105DND Transcriptional regulator C6Y56_RS26205 ENOG4105CSU acyl-Coa dehydrogenase C6Y56_RS26210 ENOG4105CSU acyl-Coa dehydrogenase C6Y56_RS26215 ENOG4106TD9 Diguanylate cyclase C6Y56_RS26225 ENOG4105CSU acyl-Coa dehydrogenase C6Y56_RS26245 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C6Y56_RS26250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C6Y56_RS26255 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C6Y56_RS26260 ENOG4105MJ2 Competence protein C6Y56_RS26265 ENOG4105F4R Transcriptional regulator mode C6Y56_RS26275 ENOG4105E27 serine threonine protein kinase C6Y56_RS26280 ENOG4105FR1 rard protein C6Y56_RS26290 ENOG4107QP3 malate synthase g C6Y56_RS26295 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS26305 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C6Y56_RS26310 ENOG4108SF5 RNA Polymerase C6Y56_RS26315 ENOG4108S3W Anti-feci sigma factor, fecr C6Y56_RS26320 ENOG4105E0K tonB-dependent siderophore receptor C6Y56_RS26335 ENOG4108U78 Glutathione S-transferase C6Y56_RS26340 ENOG4105CT7 inner membrane cred family protein C6Y56_RS26350 ENOG4105EB3 Histidine kinase C6Y56_RS26355 ENOG4105E3W Two component transcriptional regulator (Winged helix family C6Y56_RS26360 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C6Y56_RS26365 ENOG4106HNH Acyl-transferase C6Y56_RS26410 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C6Y56_RS26430 ENOG4105CHR reductase C6Y56_RS26435 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C6Y56_RS26440 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit C6Y56_RS26465 ENOG4105C10 Electron transfer flavoprotein C6Y56_RS26470 ENOG4105DF6 Fe-S oxidoreductase C6Y56_RS26515 ENOG4105ECQ AraC Family Transcriptional Regulator C6Y56_RS26525 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme C6Y56_RS26530 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) C6Y56_RS26550 ENOG4105ECQ AraC Family Transcriptional Regulator C6Y56_RS26555 ENOG4105EJQ L-serine dehydratase C6Y56_RS26565 ENOG4108HQS Glycine betaine C6Y56_RS26570 ENOG4108IJ7 Glycine betaine C6Y56_RS26575 ENOG4105C94 Transporter C6Y56_RS26580 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) C6Y56_RS26585 ENOG4105C26 Dehydrogenase C6Y56_RS26590 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) C6Y56_RS26615 ENOG4105CMS peptidase U62, modulator of DNA gyrase C6Y56_RS26620 ENOG4105C0R drug resistance transporter emrb qaca subfamily C6Y56_RS26625 ENOG4105C1J atp-dependent rna helicase C6Y56_RS26630 ENOG4105CBX hi0933 family C6Y56_RS26635 ENOG4105EM2 membrane C6Y56_RS26645 ENOG4107YB6 acetyltransferase, (GNAT) family C6Y56_RS26655 ENOG4108VKG metal-dependent hydrolase C6Y56_RS26660 ENOG4105BZU Histidine kinase C6Y56_RS26705 ENOG4105D2N Aldolase C6Y56_RS26720 ENOG4105BZA Phosphoglycerate kinase C6Y56_RS26725 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C6Y56_RS26730 ENOG4105CV1 Transketolase (EC 2.2.1.1) C6Y56_RS26735 ENOG4105YVS arsR family transcriptional regulator C6Y56_RS26740 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C6Y56_RS26745 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) C6Y56_RS26775 ENOG4105EEQ Na H antiporter C6Y56_RS26780 ENOG4105S64 Formate nitrite transporter C6Y56_RS26790 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C6Y56_RS26795 ENOG4105SYT Methylenetetrahydrofolate reductase C6Y56_RS26805 ENOG4105C1J atp-dependent rna helicase C6Y56_RS26810 ENOG4108YYC ycei family C6Y56_RS26815 ENOG4105DS1 cytochrome b561 C6Y56_RS26830 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C6Y56_RS26835 ENOG4107RP9 extracellular solute-binding protein, family 3 C6Y56_RS26840 ENOG4105MWK D-amino acid dehydrogenase, small subunit C6Y56_RS26850 ENOG4108UT2 hemolysin iii C6Y56_RS26855 ENOG4108K70 Transcriptional regulator C6Y56_RS26875 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase C6Y56_RS26890 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) C6Y56_RS26895 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase C6Y56_RS26915 ENOG4105C8Q Methyl-accepting chemotaxis C6Y56_RS26920 ENOG4108ZGA chew protein C6Y56_RS26925 ENOG4105M3Z response regulator C6Y56_RS26930 ENOG4108UNF response regulator C6Y56_RS26935 ENOG4105D7Z glutathione synthase C6Y56_RS26945 ENOG4108UJU UPF0301 protein C6Y56_RS26950 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C6Y56_RS26955 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C6Y56_RS26960 ENOG4105CXT aspartate transcarbamylase C6Y56_RS26965 ENOG4105CD3 dihydroorotase C6Y56_RS26975 ENOG4108YS0 lipoprotein YafL C6Y56_RS26980 ENOG4105CZX twitching motility protein C6Y56_RS26985 ENOG4105DFA alanine racemase domain protein C6Y56_RS26990 ENOG4105II7 pyrroline-5-carboxylate reductase C6Y56_RS26995 ENOG4108VIA integral membrane protein C6Y56_RS27000 ENOG4105VZ9 UPF0235 protein C6Y56_RS27005 ENOG4105DWV Homoserine O-trans-acetylase C6Y56_RS27010 ENOG4105DWV Homoserine O-trans-acetylase C6Y56_RS27020 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C6Y56_RS27025 ENOG4105CSA Coproporphyrinogen iii oxidase C6Y56_RS27035 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C6Y56_RS27040 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C6Y56_RS27045 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C6Y56_RS27055 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase C6Y56_RS27060 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C6Y56_RS27065 ENOG4105CRP Part of the ABC transporter FtsEX involved in C6Y56_RS27070 ENOG4105CAK Cell division ATP-binding protein ftsE C6Y56_RS27075 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C6Y56_RS27090 ENOG4106H78 methyltransferase C6Y56_RS27105 ENOG4105DNZ Alpha Beta Hydrolase C6Y56_RS27115 ENOG4105KHC sulfurtransferase C6Y56_RS27125 ENOG4107RGH Aldehyde dehydrogenase C6Y56_RS27140 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C6Y56_RS27145 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C6Y56_RS27155 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C6Y56_RS27165 ENOG4105DR4 Methyltransferase C6Y56_RS27180 ENOG4105E5M Multidrug resistance protein D C6Y56_RS27185 ENOG4105C01 Dihydroxy-acid dehydratase C6Y56_RS27195 ENOG4108ETY sodium dicarboxylate symporter C6Y56_RS27210 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C6Y56_RS27230 ENOG4105C4Y ABC transporter C6Y56_RS27240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS27245 ENOG4105DUM transcriptional regulator, lysR family C6Y56_RS27255 ENOG4105W1Y Transcriptional regulator C6Y56_RS27260 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C6Y56_RS27265 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C6Y56_RS27270 ENOG4105HF0 Membrane C6Y56_RS27280 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase C6Y56_RS27285 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C6Y56_RS27300 ENOG4105C7B Threonine dehydratase C6Y56_RS27305 ENOG4105E66 phosphoriboisomerase A C6Y56_RS27310 ENOG4108ZK4 sdia-regulated domain-containing protein C6Y56_RS27315 ENOG4108ZK4 sdia-regulated domain-containing protein C6Y56_RS27320 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase C6Y56_RS27325 ENOG4105CQB FAD linked oxidase domain protein C6Y56_RS27330 ENOG4108JQ1 Dehydrogenase C6Y56_RS27340 ENOG4108HW3 (ABC) transporter C6Y56_RS27345 ENOG4105EWC Purine nucleoside phosphorylase C6Y56_RS27370 ENOG4105CUJ penicillin amidase C6Y56_RS27385 ENOG4105D38 putrescine abc transporter C6Y56_RS27390 ENOG4105F38 ABC transporter, permease C6Y56_RS27395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS27400 ENOG4108HM4 ABC transporter C6Y56_RS27410 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C6Y56_RS27415 ENOG4105CFQ glutamine synthetase C6Y56_RS27425 ENOG4105CFQ glutamine synthetase C6Y56_RS27435 ENOG4105F4R Transcriptional regulator mode C6Y56_RS27440 ENOG4105E2Y ABC, transporter C6Y56_RS27445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C6Y56_RS27450 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C6Y56_RS27455 ENOG4105GVF (ABC) transporter C6Y56_RS27465 ENOG4105D3R alkyl hydroperoxide reductase C6Y56_RS27470 ENOG41090KI Outer membrane porin C6Y56_RS27475 ENOG4106FTQ Taurine ABC transporter, periplasmic C6Y56_RS27480 ENOG4107QZM n-acetylglutamate synthase C6Y56_RS27495 ENOG4108XM1 transcriptional regulator AsnC family C6Y56_RS27505 ENOG4107QHF type ii secretion system protein e C6Y56_RS27515 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C6Y56_RS27520 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C6Y56_RS27525 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C6Y56_RS27530 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C6Y56_RS27535 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component C6Y56_RS27540 ENOG4107QKW extracellular solute-binding protein family 1 C6Y56_RS27545 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C6Y56_RS27555 ENOG4105D0A hydroxylase C6Y56_RS27560 ENOG4107RAQ aminopeptidase C6Y56_RS27565 ENOG4105E07 UPF0149 protein C6Y56_RS27575 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) C6Y56_RS27585 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C6Y56_RS27600 ENOG4105D0S secretion protein (HlyD C6Y56_RS27605 ENOG4105CJ1 ABC, transporter C6Y56_RS27610 ENOG4105CMI transporter C6Y56_RS27625 ENOG41067XB TonB family C6Y56_RS27635 ENOG4105CXY transporter C6Y56_RS27655 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C6Y56_RS27670 ENOG4105K63 Thioredoxin C6Y56_RS27675 ENOG41073TP transcriptional regulator C6Y56_RS27680 ENOG4108HW3 (ABC) transporter C6Y56_RS27685 ENOG4105DRP amino acid AbC transporter C6Y56_RS27690 ENOG4105E5Q amino acid AbC transporter C6Y56_RS27695 ENOG4105CDA abc transporter atp-binding protein C6Y56_RS27700 ENOG4105C9X ppx gppa phosphatase C6Y56_RS27705 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C6Y56_RS27710 ENOG4105D52 delta-aminolevulinic acid dehydratase C6Y56_RS27715 ENOG4105KHU inner membrane protein YohD C6Y56_RS27725 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain C6Y56_RS27730 ENOG4108UPT UPF0178 protein C6Y56_RS27735 ENOG4107SJW iron permease, FTR1 C6Y56_RS27765 ENOG410829K Lysine exporter protein (Lyse ygga) C6Y56_RS27775 ENOG4105C5H ABC transporter C6Y56_RS27795 ENOG4105PBF Anti-RNA polymerase sigma 70 factor C6Y56_RS27800 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C6Y56_RS27815 ENOG41076E6 Uroporphyrinogen-III Synthase C6Y56_RS27820 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C6Y56_RS27825 ENOG4108NEV two component transcriptional regulator, LytTR family C6Y56_RS27830 ENOG4105CH7 arginosuccinase C6Y56_RS27835 ENOG4105IU3 Glutathione S-transferase C6Y56_RS27850 ENOG4107T0K Adenylate cyclase C6Y56_RS27855 ENOG4105NXH GreA GreB family elongation factor C6Y56_RS27865 ENOG4105XQ6 frataxin-like protein C6Y56_RS27875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C6Y56_RS27880 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C6Y56_RS27890 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C6Y56_RS27905 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C6Y56_RS27910 ENOG4105BZU Histidine kinase C6Y56_RS27915 ENOG4108YZA Nitrogen regulatory protein pii C6Y56_RS27920 ENOG4105W0Z cytoplasmic protein C6Y56_RS27930 ENOG4105VDM plasmid maintenance system antidote protein, xre family C6Y56_RS27945 ENOG4105C0P Mg chelatase subunit ChlI C6Y56_RS27955 ENOG4108NVR Methyl-accepting chemotaxis C6Y56_RS27960 ENOG4105ETT transcriptional Regulator, LysR family C6Y56_RS27965 ENOG4107QI1 Mate efflux family protein C6Y56_RS27970 ENOG4105BZU Histidine kinase C6Y56_RS27975 ENOG4105C4R Atp-dependent dna helicase C6Y56_RS27980 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C6Y56_RS27985 ENOG4105CYC Transferase C6Y56_RS27990 ENOG4105MPD Cytochrome C6Y56_RS28000 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C6Y56_RS28010 ENOG4105MWK D-amino acid dehydrogenase, small subunit C6Y56_RS28015 ENOG4105EW9 transcriptional regulator AsnC family C6Y56_RS28025 ENOG4105CJP fad dependent oxidoreductase C6Y56_RS28035 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C6Y56_RS28040 ENOG4107RZC phospholipase d C6Y56_RS28050 ENOG4105C26 Dehydrogenase C6Y56_RS28060 ENOG4105W0E 50S ribosomal protein L33 C6Y56_RS28065 ENOG4105KDC 50s ribosomal protein l28 C6Y56_RS28075 ENOG4105DEF Extracellular solute-binding protein, family 5 C6Y56_RS28080 ENOG4105W5Q DNA repair protein (RadC C6Y56_RS28085 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C6Y56_RS28090 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C6Y56_RS28095 ENOG4107QKV phosphomannomutase C6Y56_RS28100 ENOG4105CAS nag kinase C6Y56_RS28105 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C6Y56_RS28110 ENOG4105CGK Exodeoxyribonuclease III C6Y56_RS28120 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C6Y56_RS28125 ENOG4105DSJ YicC domain protein C6Y56_RS28130 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C6Y56_RS28135 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C6Y56_RS28140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C6Y56_RS28145 ENOG4105KME endoribonuclease L-psp C6Y56_RS28165 ENOG4108ZZF transport protein (ExbD) C6Y56_RS28170 ENOG4105YHG TonB family C6Y56_RS28175 ENOG4105C5Q Transcriptional regulator C6Y56_RS28180 ENOG4105CB5 ATP-dependent DNA helicase recG C6Y56_RS28245 ENOG4105ECP epimerase C6Y56_RS28300 ENOG4105D9P serine threonine protein kinase C6Y56_RS28340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C6Y56_RS28345 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C6Y56_RS28410 ENOG4108HPI phosphatidate Cytidylyltransferase C6Y56_RS28415 ENOG4105NYX DNA-binding protein C6Y56_RS28420 ENOG4107QZF nitrite reductase NADPH large subunit C6Y56_RS28430 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C6Y56_RS28435 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) C6Y56_RS28445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C6Y56_RS28450 ENOG4105BZU Histidine kinase C6Y56_RS28455 ENOG4105C37 (CBS) domain C6Y56_RS28460 ENOG4105DR5 peptidase C6Y56_RS28465 ENOG4108VYJ response regulator receiver protein C6Y56_RS28470 ENOG4108UTW Plays a role in the regulation of phosphate uptake C6Y56_RS28475 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C6Y56_RS28480 ENOG4105C8U phosphate abc transporter C6Y56_RS28485 ENOG4105C8U phosphate abc transporter C6Y56_RS28490 ENOG4105DJH phosphate C6Y56_RS28495 ENOG4105CSH Transporter C6Y56_RS28500 ENOG4105NAU thioesterase Superfamily protein C6Y56_RS28505 ENOG4105DSB aldose 1-epimerase C6Y56_RS28520 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C6Y56_RS28525 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C6Y56_RS28535 ENOG4107YNJ LysR family Transcriptional regulator C6Y56_RS28540 ENOG4108IJ0 Aspartate ammonia-lyase C6Y56_RS28550 ENOG4105HDK L-asparaginase C6Y56_RS28575 ENOG41067B5 Histone deacetylase superfamily protein C6Y56_RS28595 ENOG4105K5X acetyltransferase C6Y56_RS28615 ENOG4107QSA Oxaloacetate decarboxylase C6Y56_RS28620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C6Y56_RS28635 ENOG4106KNT transcriptional regulator C6Y56_RS28640 ENOG4105BZU Histidine kinase C6Y56_RS28645 ENOG4105C4R Atp-dependent dna helicase C6Y56_RS28665 ENOG4105CKD glutathione-regulated potassium-efflux system protein C6Y56_RS28670 ENOG4108S4H thioesterase Superfamily protein C6Y56_RS28675 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) C6Y56_RS28685 ENOG4105CKI cobalamin synthesis protein C6Y56_RS28710 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C6Y56_RS28715 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) C6Y56_RS28720 ENOG4105DIK (ABC) transporter C6Y56_RS28725 ENOG4105CC5 ABC transporter C6Y56_RS28730 ENOG4105DSE periplasmic solute binding protein C6Y56_RS28740 ENOG4105CD3 dihydroorotase C6Y56_RS28745 ENOG41060X7 Protein of unknown function (DUF3617) C6Y56_RS28750 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C6Y56_RS28755 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C6Y56_RS28780 ENOG4107QN2 dihydrolipoyl dehydrogenase C6Y56_RS28785 ENOG4105J0Q Transcriptional regulator C6Y56_RS28790 ENOG410829K Lysine exporter protein (Lyse ygga) C6Y56_RS28810 ENOG4105EXC Acyl-transferase C6Y56_RS28830 ENOG4108DMA Nad-dependent epimerase dehydratase C6Y56_RS28835 ENOG4105C0K Gdp-mannose 4,6-dehydratase C6Y56_RS28850 ENOG4105EY8 ABC transporter C6Y56_RS28860 ENOG4107STW synthase C6Y56_RS28870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C6Y56_RS28880 ENOG4105EJC lysr family transcriptional regulator C6Y56_RS28885 ENOG4105C85 amino acid C6Y56_RS28890 ENOG4105C84 Histidine ammonia-lyase C6Y56_RS28895 ENOG4105CGP Urocanate hydratase C6Y56_RS28900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C6Y56_RS28905 ENOG410804X Transcriptional regulator C6Y56_RS28910 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C6Y56_RS28915 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C6Y56_RS28920 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C6Y56_RS28925 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C6Y56_RS28930 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C6Y56_RS28935 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C6Y56_RS28940 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C6Y56_RS28945 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C6Y56_RS28950 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) C6Y56_RS28955 ENOG41064MJ ATP synthase, subunit I C6Y56_RS28960 ENOG4105FA0 parb-like partition protein C6Y56_RS28965 ENOG4107QJE Chromosome Partitioning Protein C6Y56_RS28970 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C6Y56_RS28975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C6Y56_RS28980 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C6Y56_RS28985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C6Y56_RS28990 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C6Y56_RS28995 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C6Y56_RS29000 ENOG4105VG0 50S ribosomal protein l34