locus-tag	class	description
C6Y56_RS00010	COG0592	DNA-directed DNA polymerase activity
C6Y56_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6Y56_RS00020	COG0187	DNA topoisomerase II activity
C6Y56_RS00030	COG2205	protein histidine kinase activity
C6Y56_RS00040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C6Y56_RS00045	COG0751	glycine-tRNA ligase activity
C6Y56_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
C6Y56_RS00055	COG2818	Glycosylase
C6Y56_RS00070	COG0569	domain protein
C6Y56_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6Y56_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6Y56_RS00085	COG0242	peptide deformylase activity
C6Y56_RS00095	COG0758	DNA mediated transformation
C6Y56_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
C6Y56_RS00110	COG0408	coproporphyrinogen oxidase activity
C6Y56_RS00115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6Y56_RS00130	COG3119	arylsulfatase activity
C6Y56_RS00155	COG2851	Citrate transporter
C6Y56_RS00160	COG0861	Integral membrane protein TerC family
C6Y56_RS00165	COG1283	sodium-dependent phosphate transmembrane transporter activity
C6Y56_RS00170	COG0612	Peptidase, M16
C6Y56_RS00180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6Y56_RS00185	COG1127	ABC transporter
C6Y56_RS00200	COG0700	Nucleoside recognition
C6Y56_RS00205	COG1301	dicarboxylic acid transport
C6Y56_RS00215	COG5487	UPF0391 membrane protein
C6Y56_RS00225	COG2204	response regulator
C6Y56_RS00230	COG5002	protein histidine kinase activity
C6Y56_RS00235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C6Y56_RS00240	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6Y56_RS00255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6Y56_RS00270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C6Y56_RS00290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C6Y56_RS00295	COG0735	belongs to the Fur family
C6Y56_RS00300	COG1121	(ABC) transporter
C6Y56_RS00305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6Y56_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6Y56_RS00325	COG2011	ABC-type metal ion transport system permease component
C6Y56_RS00340	COG0109	protoheme IX farnesyltransferase activity
C6Y56_RS00370	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C6Y56_RS00375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6Y56_RS00380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6Y56_RS00390	COG0659	secondary active sulfate transmembrane transporter activity
C6Y56_RS00430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C6Y56_RS00435	COG0339	signal peptide processing
C6Y56_RS00440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6Y56_RS00470	COG1764	response to oxidative stress
C6Y56_RS00475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y56_RS00485	COG3360	Dodecin
C6Y56_RS00500	COG0133	tryptophan synthase activity
C6Y56_RS00505	COG0159	tryptophan synthase activity
C6Y56_RS00545	COG0427	acetyl-CoA hydrolase
C6Y56_RS00565	COG0583	DNA-binding transcription factor activity
C6Y56_RS00620	COG3712	iron ion homeostasis
C6Y56_RS00625	COG1595	DNA-templated transcription, initiation
C6Y56_RS00630	COG0840	transmembrane signaling receptor activity
C6Y56_RS00655	COG1802	Transcriptional regulator
C6Y56_RS00665	COG5001	Diguanylate cyclase
C6Y56_RS00665	COG3300	MHYT domain
C6Y56_RS00680	COG1538	Outer membrane efflux protein
C6Y56_RS00685	COG2274	protein secretion by the type I secretion system
C6Y56_RS00690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS00695	COG2175	clavaminate synthase activity
C6Y56_RS00705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C6Y56_RS00710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y56_RS00795	COG0330	HflC and HflK could
C6Y56_RS00825	COG1289	transmembrane transporter activity
C6Y56_RS00835	COG1566	PFAM secretion protein HlyD family protein
C6Y56_RS00850	COG5339	Protein conserved in bacteria
C6Y56_RS00855	COG0457	Tetratricopeptide repeat
C6Y56_RS00860	COG0726	polysaccharide deacetylase
C6Y56_RS00860	COG1649	PFAM Uncharacterised BCR, COG1649
C6Y56_RS00865	COG1215	transferase activity, transferring glycosyl groups
C6Y56_RS00885	COG2304	oxidoreductase activity
C6Y56_RS00890	COG1595	DNA-templated transcription, initiation
C6Y56_RS00910	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS00915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6Y56_RS00945	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C6Y56_RS00955	COG4208	sulfate ABC transporter
C6Y56_RS00960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C6Y56_RS01020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y56_RS01025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y56_RS01050	COG4771	TonB-dependent receptor
C6Y56_RS01095	COG0765	amino acid transport
C6Y56_RS01100	COG0765	amino acid transport
C6Y56_RS01105	COG1126	abc transporter atp-binding protein
C6Y56_RS01110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS01115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6Y56_RS01130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y56_RS01145	COG2011	ABC-type metal ion transport system permease component
C6Y56_RS01150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6Y56_RS01155	COG1464	Belongs to the NlpA lipoprotein family
C6Y56_RS01195	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C6Y56_RS01200	COG1045	serine acetyltransferase
C6Y56_RS01205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6Y56_RS01215	COG1609	Transcriptional regulator
C6Y56_RS01225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y56_RS01230	COG0667	Aldo Keto reductase
C6Y56_RS01235	COG2175	clavaminate synthase activity
C6Y56_RS01240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y56_RS01245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C6Y56_RS01250	COG4521	taurine ABC transporter
C6Y56_RS01255	COG2918	glutathione biosynthetic process
C6Y56_RS01265	COG2183	response to ionizing radiation
C6Y56_RS01270	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS01280	COG0189	ligase activity
C6Y56_RS01285	COG0189	ligase activity
C6Y56_RS01285	COG4067	protein conserved in archaea
C6Y56_RS01290	COG2199	diguanylate cyclase activity
C6Y56_RS01290	COG2200	EAL domain
C6Y56_RS01290	COG3287	FIST C domain
C6Y56_RS01295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6Y56_RS01305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C6Y56_RS01310	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C6Y56_RS01345	COG0514	ATP-dependent DNA helicase (RecQ)
C6Y56_RS01350	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y56_RS01350	COG1024	Enoyl-CoA hydratase
C6Y56_RS01365	COG0243	molybdopterin cofactor binding
C6Y56_RS01370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6Y56_RS01375	COG0583	DNA-binding transcription factor activity
C6Y56_RS01380	COG1652	LysM domain
C6Y56_RS01385	COG1011	Hydrolase
C6Y56_RS01390	COG0494	nUDIX hydrolase
C6Y56_RS01395	COG1218	3'(2'),5'-bisphosphate nucleotidase
C6Y56_RS01420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6Y56_RS01425	COG2957	Belongs to the agmatine deiminase family
C6Y56_RS01480	COG3041	Addiction module toxin RelE StbE family
C6Y56_RS01485	COG1942	4-Oxalocrotonate Tautomerase
C6Y56_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS01530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS01570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C6Y56_RS01575	COG1194	a g-specific adenine glycosylase
C6Y56_RS01585	COG2223	nitrite transmembrane transporter activity
C6Y56_RS01590	COG0131	Imidazoleglycerol-phosphate dehydratase
C6Y56_RS01595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6Y56_RS01605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6Y56_RS01610	COG0107	imidazoleglycerol-phosphate synthase activity
C6Y56_RS01625	COG2861	carbohydrate metabolic process
C6Y56_RS01630	COG0793	Belongs to the peptidase S41A family
C6Y56_RS01635	COG4942	peptidase
C6Y56_RS01640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C6Y56_RS01655	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C6Y56_RS01660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C6Y56_RS01675	COG3852	Histidine kinase
C6Y56_RS01700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6Y56_RS01700	COG0301	tRNA thio-modification
C6Y56_RS01715	COG0058	SHG alpha-glucan phosphorylase activity
C6Y56_RS01730	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C6Y56_RS01755	COG3040	lipid binding
C6Y56_RS01760	COG0402	S-adenosylhomocysteine deaminase activity
C6Y56_RS01765	COG2188	Transcriptional regulator
C6Y56_RS01775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6Y56_RS01780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6Y56_RS01790	COG4176	ABC-type proline glycine betaine transport system permease component
C6Y56_RS01795	COG0517	IMP dehydrogenase activity
C6Y56_RS01795	COG4175	Glycine betaine
C6Y56_RS01800	COG2986	histidine ammonia-lyase
C6Y56_RS01805	COG2986	histidine ammonia-lyase
C6Y56_RS01810	COG1228	amidohydrolase
C6Y56_RS01835	COG1490	D-aminoacyl-tRNA deacylase activity
C6Y56_RS01840	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C6Y56_RS01845	COG2943	transferase activity, transferring hexosyl groups
C6Y56_RS01855	COG0765	amino acid transport
C6Y56_RS01865	COG0840	transmembrane signaling receptor activity
C6Y56_RS01880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6Y56_RS01885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6Y56_RS01890	COG0140	phosphoribosyl-ATP diphosphatase activity
C6Y56_RS01895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6Y56_RS01900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6Y56_RS01910	COG2226	methyltransferase
C6Y56_RS01955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C6Y56_RS01960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C6Y56_RS01970	COG0018	arginyl-trna synthetase
C6Y56_RS01975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6Y56_RS01980	COG0254	rRNA binding
C6Y56_RS01990	COG0281	malic enzyme
C6Y56_RS02025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6Y56_RS02030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6Y56_RS02040	COG0070	glutamate synthase
C6Y56_RS02040	COG0067	glutamate synthase
C6Y56_RS02040	COG0069	glutamate synthase activity
C6Y56_RS02045	COG0493	'glutamate synthase
C6Y56_RS02050	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6Y56_RS02055	COG2814	Major facilitator Superfamily
C6Y56_RS02060	COG0583	DNA-binding transcription factor activity
C6Y56_RS02075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y56_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS02090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y56_RS02140	COG0463	Glycosyl transferase, family 2
C6Y56_RS02145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y56_RS02155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y56_RS02160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y56_RS02175	COG1192	Involved in chromosome partitioning
C6Y56_RS02180	COG3118	belongs to the thioredoxin family
C6Y56_RS02185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C6Y56_RS02190	COG3264	Mechanosensitive ion channel
C6Y56_RS02190	COG1196	nuclear chromosome segregation
C6Y56_RS02195	COG3263	regulation of cellular component size
C6Y56_RS02220	COG0840	transmembrane signaling receptor activity
C6Y56_RS02225	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS02230	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6Y56_RS02230	COG0506	proline dehydrogenase activity
C6Y56_RS02230	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6Y56_RS02235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y56_RS02240	COG3501	Rhs element vgr protein
C6Y56_RS02275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C6Y56_RS02280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y56_RS02305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6Y56_RS02310	COG0859	PFAM glycosyl transferase family 9
C6Y56_RS02315	COG0859	PFAM glycosyl transferase family 9
C6Y56_RS02320	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS02355	COG2192	nodulation
C6Y56_RS02360	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS02375	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS02380	COG1215	transferase activity, transferring glycosyl groups
C6Y56_RS02395	COG1132	(ABC) transporter
C6Y56_RS02405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6Y56_RS02405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C6Y56_RS02415	COG0667	Aldo Keto reductase
C6Y56_RS02430	COG0583	DNA-binding transcription factor activity
C6Y56_RS02435	COG1519	Transferase
C6Y56_RS02440	COG1538	Outer membrane efflux protein
C6Y56_RS02445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C6Y56_RS02460	COG0494	nUDIX hydrolase
C6Y56_RS02470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6Y56_RS02475	COG3150	esterase
C6Y56_RS02490	COG3577	Aspartyl protease
C6Y56_RS02510	COG3830	Belongs to the UPF0237 family
C6Y56_RS02510	COG0560	Phosphoserine phosphatase
C6Y56_RS02525	COG0688	phosphatidylethanolamine metabolic process
C6Y56_RS02545	COG1360	Flagellar Motor Protein
C6Y56_RS02550	COG1162	GTPase activity
C6Y56_RS02555	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C6Y56_RS02560	COG2860	membrane
C6Y56_RS02590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6Y56_RS02590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6Y56_RS02595	COG0802	atpase or kinase
C6Y56_RS02600	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6Y56_RS02605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6Y56_RS02610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6Y56_RS02615	COG1923	regulation of RNA biosynthetic process
C6Y56_RS02620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6Y56_RS02625	COG0330	HflC and HflK could
C6Y56_RS02630	COG0330	HflC and HflK could
C6Y56_RS02635	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C6Y56_RS02640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6Y56_RS02650	COG1178	ABC-type Fe3 transport system permease component
C6Y56_RS02655	COG1840	ABC-type Fe3 transport system, periplasmic component
C6Y56_RS02670	COG0557	exoribonuclease II activity
C6Y56_RS02675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6Y56_RS02680	COG0360	Binds together with S18 to 16S ribosomal RNA
C6Y56_RS02685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6Y56_RS02695	COG0359	binds to the 23S rRNA
C6Y56_RS02700	COG0305	Participates in initiation and elongation during chromosome replication
C6Y56_RS02710	COG1032	radical SAM domain protein
C6Y56_RS02720	COG2307	Protein conserved in bacteria
C6Y56_RS02720	COG2308	Evidence 4 Homologs of previously reported genes of
C6Y56_RS02745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C6Y56_RS02750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C6Y56_RS02755	COG0583	DNA-binding transcription factor activity
C6Y56_RS02760	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS02765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS02775	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6Y56_RS02795	COG4221	oxidoreductase activity
C6Y56_RS02815	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C6Y56_RS02820	COG0830	nickel cation binding
C6Y56_RS02825	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C6Y56_RS02830	COG1309	transcriptional regulator
C6Y56_RS02840	COG2982	Protein involved in outer membrane biogenesis
C6Y56_RS02850	COG0583	DNA-binding transcription factor activity
C6Y56_RS02855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6Y56_RS02865	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C6Y56_RS02870	COG0697	spore germination
C6Y56_RS02890	COG0443	Heat shock 70 kDa protein
C6Y56_RS02895	COG0484	heat shock protein binding
C6Y56_RS02900	COG0789	Transcriptional regulator
C6Y56_RS02915	COG0804	urea catabolic process
C6Y56_RS02920	COG0832	Belongs to the urease beta subunit family
C6Y56_RS02935	COG0831	urea catabolic process
C6Y56_RS02940	COG0829	nickel cation binding
C6Y56_RS02950	COG0411	ABC transporter
C6Y56_RS02965	COG0683	leucine binding
C6Y56_RS02970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6Y56_RS02980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C6Y56_RS03015	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6Y56_RS03020	COG3657	addiction module killer protein
C6Y56_RS03030	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C6Y56_RS03040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y56_RS03060	COG2095	MarC family integral membrane protein
C6Y56_RS03070	COG0151	Belongs to the GarS family
C6Y56_RS03075	COG0138	bifunctional purine biosynthesis protein purh
C6Y56_RS03085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6Y56_RS03095	COG2264	protein methyltransferase activity
C6Y56_RS03135	COG0023	Translation Initiation Factor
C6Y56_RS03140	COG1166	arginine decarboxylase activity
C6Y56_RS03145	COG3501	Rhs element vgr protein
C6Y56_RS03155	COG0534	Mate efflux family protein
C6Y56_RS03170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y56_RS03240	COG4964	Belongs to the GSP D family
C6Y56_RS03275	COG2030	dehydratase
C6Y56_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS03285	COG0183	Belongs to the thiolase family
C6Y56_RS03290	COG2801	Transposase and inactivated derivatives
C6Y56_RS03290	COG3415	Transposase
C6Y56_RS03295	COG0840	transmembrane signaling receptor activity
C6Y56_RS03315	COG2217	Heavy metal translocating P-type atpase
C6Y56_RS03325	COG2217	Heavy metal translocating P-type atpase
C6Y56_RS03330	COG2814	Major facilitator Superfamily
C6Y56_RS03340	COG0604	alcohol dehydrogenase
C6Y56_RS03350	COG0583	DNA-binding transcription factor activity
C6Y56_RS03360	COG0477	Major facilitator Superfamily
C6Y56_RS03365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6Y56_RS03380	COG0387	Pfam Sodium calcium exchanger
C6Y56_RS03415	COG1129	ABC transporter
C6Y56_RS03425	COG1309	transcriptional regulator
C6Y56_RS03470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C6Y56_RS03475	COG1074	ATP-dependent DNA helicase activity
C6Y56_RS03480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6Y56_RS03490	COG2199	diguanylate cyclase activity
C6Y56_RS03495	COG2885	chlorophyll binding
C6Y56_RS03540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C6Y56_RS03550	COG2084	Dehydrogenase
C6Y56_RS03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS03565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y56_RS03575	COG0640	Transcriptional regulator
C6Y56_RS03580	COG3161	chorismate lyase activity
C6Y56_RS03590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6Y56_RS03595	COG0583	DNA-binding transcription factor activity
C6Y56_RS03610	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6Y56_RS03615	COG0583	DNA-binding transcription factor activity
C6Y56_RS03625	COG2192	nodulation
C6Y56_RS03645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C6Y56_RS03655	COG2801	Transposase and inactivated derivatives
C6Y56_RS03655	COG3415	Transposase
C6Y56_RS03670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6Y56_RS03675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6Y56_RS03695	COG0840	transmembrane signaling receptor activity
C6Y56_RS03710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6Y56_RS03795	COG0247	lactate metabolic process
C6Y56_RS03800	COG1620	l-lactate permease
C6Y56_RS03810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6Y56_RS03815	COG0733	neurotransmitter:sodium symporter activity
C6Y56_RS03825	COG2914	Belongs to the UPF0125 (RnfH) family
C6Y56_RS03830	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6Y56_RS03835	COG0735	belongs to the Fur family
C6Y56_RS03840	COG0497	DNA recombination
C6Y56_RS03845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6Y56_RS03850	COG0443	Heat shock 70 kDa protein
C6Y56_RS03855	COG0484	heat shock protein binding
C6Y56_RS03860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6Y56_RS03865	COG0505	Belongs to the CarA family
C6Y56_RS03870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6Y56_RS03875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y56_RS03890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C6Y56_RS03895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y56_RS03900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6Y56_RS03905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6Y56_RS03910	COG0149	triose-phosphate isomerase activity
C6Y56_RS03915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6Y56_RS03935	COG0195	Participates in both transcription termination and antitermination
C6Y56_RS03940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6Y56_RS03945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6Y56_RS03950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6Y56_RS03955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6Y56_RS03960	COG1185	polyribonucleotide nucleotidyltransferase activity
C6Y56_RS04010	COG0084	hydrolase, TatD family'
C6Y56_RS04015	COG1609	Transcriptional regulator
C6Y56_RS04025	COG1105	Belongs to the carbohydrate kinase PfkB family
C6Y56_RS04030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C6Y56_RS04030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6Y56_RS04030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6Y56_RS04040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C6Y56_RS04050	COG3128	pkhd-type hydroxylase
C6Y56_RS04070	COG0019	diaminopimelate decarboxylase activity
C6Y56_RS04095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6Y56_RS04120	COG4608	Belongs to the ABC transporter superfamily
C6Y56_RS04125	COG0444	Belongs to the ABC transporter superfamily
C6Y56_RS04130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y56_RS04135	COG0601	transmembrane transport
C6Y56_RS04140	COG0747	negative chemotaxis
C6Y56_RS04150	COG0747	negative chemotaxis
C6Y56_RS04155	COG0747	negative chemotaxis
C6Y56_RS04160	COG0747	negative chemotaxis
C6Y56_RS04180	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C6Y56_RS04185	COG4178	(ABC) transporter
C6Y56_RS04215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y56_RS04225	COG2271	Major facilitator Superfamily
C6Y56_RS04230	COG2721	sulfolactate sulfo-lyase activity
C6Y56_RS04240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y56_RS04250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C6Y56_RS04255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6Y56_RS04260	COG0154	amidase activity
C6Y56_RS04265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6Y56_RS04270	COG1077	Cell shape determining protein MreB Mrl
C6Y56_RS04275	COG1792	Involved in formation and maintenance of cell shape
C6Y56_RS04280	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C6Y56_RS04285	COG0424	maF-like protein
C6Y56_RS04290	COG1530	ribonuclease E activity
C6Y56_RS04300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y56_RS04305	COG0312	modulator of DNA gyrase
C6Y56_RS04310	COG3028	Belongs to the UPF0307 family
C6Y56_RS04315	COG0312	modulator of DNA gyrase
C6Y56_RS04350	COG1660	Displays ATPase and GTPase activities
C6Y56_RS04360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6Y56_RS04365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C6Y56_RS04370	COG1137	ATPase activity
C6Y56_RS04375	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C6Y56_RS04385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C6Y56_RS04395	COG1127	ABC transporter
C6Y56_RS04400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6Y56_RS04405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6Y56_RS04420	COG5007	Belongs to the BolA IbaG family
C6Y56_RS04425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6Y56_RS04430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6Y56_RS04435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6Y56_RS04440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6Y56_RS04450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6Y56_RS04460	COG0175	sulfate reduction
C6Y56_RS04470	COG0204	Acyl-transferase
C6Y56_RS04475	COG0857	belongs to the CobB CobQ family
C6Y56_RS04475	COG0280	phosphate acetyltransferase
C6Y56_RS04485	COG1047	Peptidyl-prolyl cis-trans
C6Y56_RS04490	COG0386	Belongs to the glutathione peroxidase family
C6Y56_RS04505	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C6Y56_RS04510	COG0492	ferredoxin-NADP+ reductase activity
C6Y56_RS04525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6Y56_RS04545	COG0789	Transcriptional regulator
C6Y56_RS04555	COG1366	Belongs to the anti-sigma-factor antagonist family
C6Y56_RS04565	COG0583	DNA-binding transcription factor activity
C6Y56_RS04570	COG1380	Effector of murein hydrolase LrgA
C6Y56_RS04575	COG1346	cytolysis
C6Y56_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS04610	COG2197	response regulator
C6Y56_RS04625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C6Y56_RS04630	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6Y56_RS04650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6Y56_RS04670	COG0814	amino acid
C6Y56_RS04675	COG1760	l-serine dehydratase
C6Y56_RS04680	COG0583	DNA-binding transcription factor activity
C6Y56_RS04690	COG4772	TonB-dependent receptor
C6Y56_RS04695	COG3712	iron ion homeostasis
C6Y56_RS04700	COG1595	DNA-templated transcription, initiation
C6Y56_RS04720	COG4774	siderophore transport
C6Y56_RS04745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y56_RS04755	COG0583	DNA-binding transcription factor activity
C6Y56_RS04775	COG1566	PFAM secretion protein HlyD family protein
C6Y56_RS04785	COG2814	Major facilitator Superfamily
C6Y56_RS04795	COG0300	oxidoreductase activity
C6Y56_RS04810	COG0662	Cupin 2, conserved barrel domain protein
C6Y56_RS04810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C6Y56_RS04825	COG1696	Membrane protein involved in D-alanine export
C6Y56_RS04840	COG3420	alginic acid biosynthetic process
C6Y56_RS04850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C6Y56_RS04855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS04860	COG1215	transferase activity, transferring glycosyl groups
C6Y56_RS04870	COG3022	response to hydroperoxide
C6Y56_RS04880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6Y56_RS04885	COG0315	cyclic pyranopterin monophosphate synthase activity
C6Y56_RS04890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6Y56_RS04920	COG0513	Belongs to the DEAD box helicase family
C6Y56_RS04925	COG0400	carboxylic ester hydrolase activity
C6Y56_RS04930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS04935	COG4597	amino acid ABC transporter
C6Y56_RS04940	COG0765	amino acid transport
C6Y56_RS04945	COG1126	abc transporter atp-binding protein
C6Y56_RS04950	COG2186	Transcriptional regulator
C6Y56_RS04955	COG2807	transmembrane transport
C6Y56_RS04965	COG2827	Endonuclease containing a URI domain
C6Y56_RS04980	COG3081	Nucleoid-associated protein
C6Y56_RS04990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C6Y56_RS04995	COG0525	valine-tRNA ligase activity
C6Y56_RS05010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6Y56_RS05015	COG0795	lipopolysaccharide-transporting ATPase activity
C6Y56_RS05020	COG0795	lipopolysaccharide-transporting ATPase activity
C6Y56_RS05025	COG0481	GTPase activity
C6Y56_RS05030	COG0681	Belongs to the peptidase S26 family
C6Y56_RS05035	COG0571	ribonuclease III activity
C6Y56_RS05040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6Y56_RS05045	COG1381	Involved in DNA repair and RecF pathway recombination
C6Y56_RS05050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C6Y56_RS05055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C6Y56_RS05060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6Y56_RS05060	COG0047	phosphoribosylformylglycinamidine synthase activity
C6Y56_RS05070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6Y56_RS05070	COG1263	PTS System
C6Y56_RS05070	COG2190	(PTS) system
C6Y56_RS05075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6Y56_RS05075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6Y56_RS05080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6Y56_RS05085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C6Y56_RS05090	COG2188	Transcriptional regulator
C6Y56_RS05105	COG0494	nUDIX hydrolase
C6Y56_RS05125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C6Y56_RS05130	COG0477	Major facilitator Superfamily
C6Y56_RS05135	COG4536	flavin adenine dinucleotide binding
C6Y56_RS05145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6Y56_RS05150	COG0228	four-way junction DNA binding
C6Y56_RS05155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6Y56_RS05160	COG0336	Belongs to the RNA methyltransferase TrmD family
C6Y56_RS05165	COG0335	large ribosomal subunit rRNA binding
C6Y56_RS05170	COG1607	acyl-coa hydrolase
C6Y56_RS05175	COG4974	Belongs to the 'phage' integrase family
C6Y56_RS05195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS05195	COG2205	protein histidine kinase activity
C6Y56_RS05215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y56_RS05230	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS05240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C6Y56_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS05280	COG1177	transmembrane transport
C6Y56_RS05285	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y56_RS05290	COG3842	ATPase activity
C6Y56_RS05295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6Y56_RS05305	COG0583	DNA-binding transcription factor activity
C6Y56_RS05325	COG0457	Tetratricopeptide repeat
C6Y56_RS05325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C6Y56_RS05340	COG2201	protein-glutamate methylesterase activity
C6Y56_RS05345	COG2203	Gaf domain
C6Y56_RS05345	COG3706	GGDEF domain
C6Y56_RS05345	COG4251	negative regulation of phosphorylation
C6Y56_RS05345	COG5001	Diguanylate cyclase
C6Y56_RS05355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6Y56_RS05375	COG1073	alpha beta
C6Y56_RS05400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C6Y56_RS05405	COG0563	adenylate kinase activity
C6Y56_RS05410	COG1214	PFAM Peptidase M22, glycoprotease
C6Y56_RS05420	COG1801	Protein of unknown function DUF72
C6Y56_RS05435	COG0742	ribosomal rna small subunit methyltransferase
C6Y56_RS05445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS05475	COG2937	Belongs to the GPAT DAPAT family
C6Y56_RS05490	COG2226	methyltransferase
C6Y56_RS05495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6Y56_RS05505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C6Y56_RS05515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6Y56_RS05520	COG2171	N-acyltransferase activity
C6Y56_RS05525	COG1393	Belongs to the ArsC family
C6Y56_RS05530	COG0025	NhaP-type Na H and K H
C6Y56_RS05545	COG0436	Aminotransferase
C6Y56_RS05550	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6Y56_RS05555	COG0024	Methionine aminopeptidase
C6Y56_RS05560	COG0052	Belongs to the universal ribosomal protein uS2 family
C6Y56_RS05565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6Y56_RS05570	COG0528	UMP kinase activity
C6Y56_RS05575	COG0233	cytoplasmic translational termination
C6Y56_RS05580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6Y56_RS05590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6Y56_RS05610	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y56_RS05615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y56_RS05620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y56_RS05625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y56_RS05630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6Y56_RS05635	COG0587	DNA-directed DNA polymerase activity
C6Y56_RS05640	COG0825	malonyl-CoA metabolic process
C6Y56_RS05645	COG0037	tRNA processing
C6Y56_RS05650	COG0504	CTP synthase activity
C6Y56_RS05655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C6Y56_RS05660	COG0148	phosphopyruvate hydratase activity
C6Y56_RS05670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C6Y56_RS05680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C6Y56_RS05685	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C6Y56_RS05690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6Y56_RS05695	COG0585	pseudouridine synthase activity
C6Y56_RS05700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6Y56_RS05705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6Y56_RS05725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6Y56_RS05835	COG4386	tail sheath protein
C6Y56_RS05870	COG4381	Mu-like prophage protein gp46
C6Y56_RS05925	COG3179	chitinase
C6Y56_RS05935	COG1546	Belongs to the CinA family
C6Y56_RS05940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6Y56_RS05945	COG2137	regulation of response to DNA damage stimulus
C6Y56_RS05980	COG0583	DNA-binding transcription factor activity
C6Y56_RS06000	COG4807	Protein conserved in bacteria
C6Y56_RS06015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y56_RS06020	COG3158	transport of potassium into the cell
C6Y56_RS06055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6Y56_RS06065	COG0442	prolyl-tRNA aminoacylation
C6Y56_RS06070	COG2211	Major facilitator Superfamily
C6Y56_RS06085	COG1278	Cold shock
C6Y56_RS06090	COG0717	Belongs to the dCTP deaminase family
C6Y56_RS06105	COG1201	RNA secondary structure unwinding
C6Y56_RS06110	COG4598	ABC transporter
C6Y56_RS06135	COG1793	dna ligase
C6Y56_RS06145	COG2366	antibiotic biosynthetic process
C6Y56_RS06155	COG0653	protein targeting
C6Y56_RS06165	COG3012	SEC-C Motif Domain Protein
C6Y56_RS06200	COG1199	ATP-dependent helicase activity
C6Y56_RS06220	COG0259	pyridoxamine-phosphate oxidase activity
C6Y56_RS06250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6Y56_RS06260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C6Y56_RS06275	COG0583	DNA-binding transcription factor activity
C6Y56_RS06290	COG3220	belongs to the UPF0276 family
C6Y56_RS06335	COG2084	Dehydrogenase
C6Y56_RS06345	COG0727	PFAM Uncharacterised protein family (UPF0153)
C6Y56_RS06350	COG2271	Major facilitator Superfamily
C6Y56_RS06355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6Y56_RS06375	COG0583	DNA-binding transcription factor activity
C6Y56_RS06385	COG0306	phosphate transporter
C6Y56_RS06395	COG1414	Transcriptional regulator
C6Y56_RS06400	COG2814	Major facilitator Superfamily
C6Y56_RS06405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6Y56_RS06410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6Y56_RS06415	COG0183	Belongs to the thiolase family
C6Y56_RS06420	COG3485	protocatechuate 3,4-dioxygenase
C6Y56_RS06425	COG3485	protocatechuate 3,4-dioxygenase
C6Y56_RS06430	COG0477	Major facilitator Superfamily
C6Y56_RS06440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y56_RS06445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y56_RS06480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS06490	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS06495	COG2814	Major facilitator Superfamily
C6Y56_RS06535	COG1473	amidohydrolase
C6Y56_RS06545	COG0154	amidase activity
C6Y56_RS06560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y56_RS06570	COG1704	LemA family
C6Y56_RS06575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C6Y56_RS06590	COG0697	spore germination
C6Y56_RS06595	COG0693	protein deglycase activity
C6Y56_RS06600	COG3422	double-strand break repair
C6Y56_RS06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y56_RS06610	COG0235	Class ii aldolase
C6Y56_RS06615	COG1396	sequence-specific DNA binding
C6Y56_RS06625	COG1454	alcohol dehydrogenase
C6Y56_RS06640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y56_RS06645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y56_RS06650	COG2271	Major facilitator Superfamily
C6Y56_RS06705	COG4106	trans-aconitate 2-methyltransferase activity
C6Y56_RS06735	COG2267	carboxylic ester hydrolase activity
C6Y56_RS06760	COG0439	Biotin carboxylase
C6Y56_RS06765	COG3665	Urea carboxylase-associated protein
C6Y56_RS06820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C6Y56_RS06875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C6Y56_RS06905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6Y56_RS06910	COG4783	chaperone-mediated protein folding
C6Y56_RS06915	COG0425	Belongs to the sulfur carrier protein TusA family
C6Y56_RS06920	COG0628	permease
C6Y56_RS06925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C6Y56_RS06935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y56_RS06940	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C6Y56_RS06945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6Y56_RS06950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6Y56_RS06975	COG0463	Glycosyl transferase, family 2
C6Y56_RS07010	COG2807	transmembrane transport
C6Y56_RS07015	COG2194	sulfuric ester hydrolase activity
C6Y56_RS07025	COG3100	YcgL domain-containing protein
C6Y56_RS07040	COG2983	Belongs to the UPF0260 family
C6Y56_RS07080	COG1770	oligopeptidase
C6Y56_RS07090	COG0121	glutamine amidotransferase
C6Y56_RS07100	COG0583	DNA-binding transcription factor activity
C6Y56_RS07105	COG2814	Major facilitator Superfamily
C6Y56_RS07110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y56_RS07115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y56_RS07120	COG1984	allophanate hydrolase subunit 2
C6Y56_RS07130	COG0542	response to heat
C6Y56_RS07150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6Y56_RS07180	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C6Y56_RS07185	COG1643	Atp-dependent helicase
C6Y56_RS07195	COG1595	DNA-templated transcription, initiation
C6Y56_RS07205	COG2188	Transcriptional regulator
C6Y56_RS07215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6Y56_RS07220	COG1132	(ABC) transporter
C6Y56_RS07245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6Y56_RS07255	COG0583	DNA-binding transcription factor activity
C6Y56_RS07260	COG1335	isochorismatase
C6Y56_RS07265	COG0668	transmembrane transport
C6Y56_RS07270	COG0513	Belongs to the DEAD box helicase family
C6Y56_RS07315	COG2996	Protein conserved in bacteria
C6Y56_RS07325	COG0697	spore germination
C6Y56_RS07335	COG0583	DNA-binding transcription factor activity
C6Y56_RS07350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y56_RS07445	COG2832	Protein of unknown function (DUF454)
C6Y56_RS07470	COG1752	Esterase of the alpha-beta hydrolase superfamily
C6Y56_RS07485	COG2207	Transcriptional regulator
C6Y56_RS07510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6Y56_RS07515	COG0778	Nitroreductase
C6Y56_RS07520	COG0642	Histidine kinase
C6Y56_RS07530	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS07540	COG2350	Protein conserved in bacteria
C6Y56_RS07545	COG2917	probably involved in intracellular septation
C6Y56_RS07555	COG0009	L-threonylcarbamoyladenylate synthase
C6Y56_RS07565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6Y56_RS07580	COG1113	amino acid transport
C6Y56_RS07585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6Y56_RS07600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C6Y56_RS07625	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6Y56_RS07640	COG4787	bacterial-type flagellum-dependent cell motility
C6Y56_RS07650	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C6Y56_RS07655	COG1706	bacterial-type flagellum-dependent cell motility
C6Y56_RS07665	COG1256	bacterial-type flagellum assembly
C6Y56_RS07675	COG1216	Glycosyl transferase, family 2
C6Y56_RS07675	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS07695	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C6Y56_RS07705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y56_RS07720	COG1216	Glycosyl transferase, family 2
C6Y56_RS07720	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS07725	COG1086	Polysaccharide biosynthesis protein
C6Y56_RS07730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6Y56_RS07740	COG1083	cytidylyl-transferase
C6Y56_RS07750	COG2089	acid synthase
C6Y56_RS07755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6Y56_RS07770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6Y56_RS07800	COG3852	Histidine kinase
C6Y56_RS07810	COG1677	Flagellar hook-basal body complex protein FliE
C6Y56_RS07845	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS07860	COG1580	Controls the rotational direction of flagella during chemotaxis
C6Y56_RS07885	COG1987	bacterial-type flagellum assembly
C6Y56_RS07950	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C6Y56_RS07955	COG0643	Histidine kinase
C6Y56_RS07955	COG0784	Response regulator, receiver
C6Y56_RS07955	COG2198	Histidine kinase
C6Y56_RS07960	COG2201	protein-glutamate methylesterase activity
C6Y56_RS07965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6Y56_RS07975	COG1192	Involved in chromosome partitioning
C6Y56_RS07985	COG0835	chemotaxis
C6Y56_RS08005	COG4133	protoheme IX ABC transporter activity
C6Y56_RS08025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C6Y56_RS08030	COG1138	Cytochrome C-type biogenesis protein
C6Y56_RS08040	COG3088	subunit of a heme lyase
C6Y56_RS08055	COG1569	PIN domain
C6Y56_RS08060	COG3311	Transcriptional regulator
C6Y56_RS08065	COG1598	PFAM Uncharacterised protein family UPF0150
C6Y56_RS08070	COG2814	Major facilitator Superfamily
C6Y56_RS08080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C6Y56_RS08085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y56_RS08090	COG4413	Urea transporter
C6Y56_RS08095	COG0469	pyruvate kinase activity
C6Y56_RS08105	COG2084	Dehydrogenase
C6Y56_RS08110	COG3622	Belongs to the hyi family
C6Y56_RS08115	COG3960	tartronate-semialdehyde synthase activity
C6Y56_RS08130	COG1309	transcriptional regulator
C6Y56_RS08135	COG2354	Protein conserved in bacteria
C6Y56_RS08140	COG2853	Lipoprotein
C6Y56_RS08160	COG2113	Glycine betaine
C6Y56_RS08165	COG3162	membrane
C6Y56_RS08170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y56_RS08180	COG2009	succinate dehydrogenase
C6Y56_RS08185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C6Y56_RS08190	COG1053	succinate dehydrogenase
C6Y56_RS08195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6Y56_RS08210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y56_RS08215	COG0045	succinate-CoA ligase (ADP-forming) activity
C6Y56_RS08255	COG0326	Molecular chaperone. Has ATPase activity
C6Y56_RS08265	COG1741	Belongs to the pirin family
C6Y56_RS08290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6Y56_RS08295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6Y56_RS08305	COG0628	permease
C6Y56_RS08310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6Y56_RS08315	COG0791	NLP P60 protein
C6Y56_RS08320	COG0791	NLP P60 protein
C6Y56_RS08340	COG1797	cobyrinic acid a,c-diamide synthase activity
C6Y56_RS08345	COG0778	Nitroreductase
C6Y56_RS08360	COG1492	cobalamin metabolic process
C6Y56_RS08370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6Y56_RS08380	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6Y56_RS08425	COG0784	Response regulator, receiver
C6Y56_RS08425	COG2205	protein histidine kinase activity
C6Y56_RS08440	COG0662	Cupin 2, conserved barrel domain protein
C6Y56_RS08455	COG2076	Multidrug Resistance protein
C6Y56_RS08460	COG0385	Bile acid
C6Y56_RS08465	COG2974	May be involved in recombination
C6Y56_RS08490	COG0753	catalase activity
C6Y56_RS08495	COG2010	Cytochrome c
C6Y56_RS08500	COG0545	Peptidyl-prolyl cis-trans isomerase
C6Y56_RS08530	COG2200	EAL domain
C6Y56_RS08540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6Y56_RS08540	COG3321	synthase
C6Y56_RS08540	COG4221	oxidoreductase activity
C6Y56_RS08540	COG0604	alcohol dehydrogenase
C6Y56_RS08550	COG3842	ATPase activity
C6Y56_RS08560	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y56_RS08580	COG0668	transmembrane transport
C6Y56_RS08590	COG1362	aminopeptidase activity
C6Y56_RS08600	COG0564	pseudouridine synthase activity
C6Y56_RS08605	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C6Y56_RS08610	COG2894	cell division
C6Y56_RS08615	COG0850	regulation of cytokinetic process
C6Y56_RS08620	COG1560	Kdo2-lipid A biosynthetic process
C6Y56_RS08645	COG2233	PERMEase
C6Y56_RS08655	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C6Y56_RS08660	COG4266	Belongs to the allantoicase family
C6Y56_RS08690	COG2252	PERMEase
C6Y56_RS08700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS08710	COG0302	gtp cyclohydrolase
C6Y56_RS08715	COG2840	Smr protein MutS2
C6Y56_RS08745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6Y56_RS08755	COG0235	Class ii aldolase
C6Y56_RS08760	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C6Y56_RS08765	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C6Y56_RS08800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C6Y56_RS08815	COG2308	Evidence 4 Homologs of previously reported genes of
C6Y56_RS08825	COG1305	Transglutaminase-like
C6Y56_RS08835	COG0183	Belongs to the thiolase family
C6Y56_RS08840	COG1024	Enoyl-CoA hydratase
C6Y56_RS08840	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y56_RS08845	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y56_RS08845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y56_RS08850	COG0598	Magnesium transport protein CorA
C6Y56_RS08870	COG0393	Putative heavy-metal-binding
C6Y56_RS08900	COG3209	COG3209 Rhs family protein
C6Y56_RS08900	COG3209	COG3209 Rhs family protein
C6Y56_RS08905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6Y56_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS08925	COG1953	Uracil, thiamine, allantoin
C6Y56_RS08935	COG0560	Phosphoserine phosphatase
C6Y56_RS08955	COG4067	protein conserved in archaea
C6Y56_RS08955	COG0189	ligase activity
C6Y56_RS08960	COG1802	Transcriptional regulator
C6Y56_RS08970	COG0372	Belongs to the citrate synthase family
C6Y56_RS08990	COG1116	anion transmembrane transporter activity
C6Y56_RS09000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C6Y56_RS09015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6Y56_RS09030	COG0668	transmembrane transport
C6Y56_RS09045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6Y56_RS09050	COG0243	molybdopterin cofactor binding
C6Y56_RS09055	COG2146	nitrite reductase [NAD(P)H] activity
C6Y56_RS09060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y56_RS09065	COG0515	serine threonine protein kinase
C6Y56_RS09065	COG2815	serine threonine protein kinase
C6Y56_RS09070	COG2223	nitrite transmembrane transporter activity
C6Y56_RS09075	COG3707	response regulator
C6Y56_RS09080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y56_RS09080	COG1116	anion transmembrane transporter activity
C6Y56_RS09085	COG0167	dihydroorotate dehydrogenase activity
C6Y56_RS09090	COG3130	regulation of translation
C6Y56_RS09095	COG0116	Belongs to the methyltransferase superfamily
C6Y56_RS09095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C6Y56_RS09105	COG2027	D-alanyl-D-alanine carboxypeptidase
C6Y56_RS09110	COG3171	Protein conserved in bacteria
C6Y56_RS09115	COG3135	benzoate transporter
C6Y56_RS09120	COG1802	Transcriptional regulator
C6Y56_RS09125	COG0402	S-adenosylhomocysteine deaminase activity
C6Y56_RS09155	COG3115	cell septum assembly
C6Y56_RS09160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6Y56_RS09185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6Y56_RS09190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C6Y56_RS09195	COG2130	NADP-dependent
C6Y56_RS09200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6Y56_RS09205	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS09210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6Y56_RS09215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y56_RS09250	COG0348	domain, Protein
C6Y56_RS09265	COG2010	Cytochrome c
C6Y56_RS09280	COG3278	Belongs to the heme-copper respiratory oxidase family
C6Y56_RS09285	COG2010	Cytochrome c
C6Y56_RS09300	COG3278	Belongs to the heme-copper respiratory oxidase family
C6Y56_RS09320	COG0840	transmembrane signaling receptor activity
C6Y56_RS09335	COG4977	sequence-specific DNA binding
C6Y56_RS09350	COG3387	PFAM Glycoside hydrolase 15-related
C6Y56_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS09390	COG4774	siderophore transport
C6Y56_RS09425	COG1136	(ABC) transporter
C6Y56_RS09425	COG0577	efflux transmembrane transporter activity
C6Y56_RS09430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS09445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6Y56_RS09460	COG2197	response regulator
C6Y56_RS09465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS09465	COG2205	protein histidine kinase activity
C6Y56_RS09470	COG0656	L-ascorbic acid biosynthetic process
C6Y56_RS09485	COG0708	Exodeoxyribonuclease III
C6Y56_RS09505	COG2233	PERMEase
C6Y56_RS09530	COG0556	nucleotide-excision repair
C6Y56_RS09545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y56_RS09575	COG0596	Alpha beta hydrolase
C6Y56_RS09585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6Y56_RS09600	COG2214	Heat shock protein DnaJ domain protein
C6Y56_RS09605	COG0443	Heat shock 70 kDa protein
C6Y56_RS09620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6Y56_RS09625	COG0066	3-isopropylmalate dehydratase activity
C6Y56_RS09630	COG2226	methyltransferase
C6Y56_RS09635	COG0473	3-isopropylmalate dehydrogenase activity
C6Y56_RS09660	COG0135	phosphoribosylanthranilate isomerase activity
C6Y56_RS09665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6Y56_RS09670	COG0285	dihydrofolate synthase activity
C6Y56_RS09680	COG1286	toxin biosynthetic process
C6Y56_RS09715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6Y56_RS09725	COG2010	Cytochrome c
C6Y56_RS09730	COG3608	succinylglutamate desuccinylase aspartoacylase
C6Y56_RS09730	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6Y56_RS09735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS09755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C6Y56_RS09795	COG1129	ABC transporter
C6Y56_RS09800	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6Y56_RS09810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y56_RS09815	COG1869	D-ribose catabolic process
C6Y56_RS09840	COG1278	Cold shock
C6Y56_RS09850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6Y56_RS09855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6Y56_RS09860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6Y56_RS09865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6Y56_RS09870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6Y56_RS09875	COG0072	phenylalanine-tRNA ligase activity
C6Y56_RS09880	COG0776	regulation of translation
C6Y56_RS09900	COG1477	protein flavinylation
C6Y56_RS09965	COG3718	enzyme involved in inositol metabolism
C6Y56_RS09980	COG3962	Belongs to the TPP enzyme family
C6Y56_RS09985	COG0673	inositol 2-dehydrogenase activity
C6Y56_RS09990	COG0673	inositol 2-dehydrogenase activity
C6Y56_RS10000	COG1129	ABC transporter
C6Y56_RS10005	COG4211	Belongs to the binding-protein-dependent transport system permease family
C6Y56_RS10030	COG3321	synthase
C6Y56_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS10030	COG0604	alcohol dehydrogenase
C6Y56_RS10040	COG0583	DNA-binding transcription factor activity
C6Y56_RS10045	COG1741	Belongs to the pirin family
C6Y56_RS10090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C6Y56_RS10095	COG1335	isochorismatase
C6Y56_RS10110	COG0583	DNA-binding transcription factor activity
C6Y56_RS10130	COG1196	nuclear chromosome segregation
C6Y56_RS10130	COG0741	lytic transglycosylase activity
C6Y56_RS10130	COG0739	heme binding
C6Y56_RS10165	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS10195	COG4796	Type ii and iii secretion system protein
C6Y56_RS10225	COG1462	curli production assembly transport component CsgG
C6Y56_RS10270	COG5002	protein histidine kinase activity
C6Y56_RS10285	COG4191	Histidine kinase
C6Y56_RS10300	COG0500	methyltransferase
C6Y56_RS10335	COG0726	polysaccharide deacetylase
C6Y56_RS10355	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS10420	COG2720	vancomycin resistance protein
C6Y56_RS10460	COG3501	Rhs element vgr protein
C6Y56_RS10470	COG5383	Protein conserved in bacteria
C6Y56_RS10475	COG2267	carboxylic ester hydrolase activity
C6Y56_RS10480	COG2072	flavoprotein involved in K transport
C6Y56_RS10485	COG3706	GGDEF domain
C6Y56_RS10495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C6Y56_RS10510	COG0531	amino acid
C6Y56_RS10525	COG1335	isochorismatase
C6Y56_RS10590	COG0583	DNA-binding transcription factor activity
C6Y56_RS10610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6Y56_RS10615	COG0583	DNA-binding transcription factor activity
C6Y56_RS10620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6Y56_RS10625	COG4106	trans-aconitate 2-methyltransferase activity
C6Y56_RS10630	COG3220	belongs to the UPF0276 family
C6Y56_RS10645	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS10720	COG0579	oxidoreductase
C6Y56_RS10735	COG1073	alpha beta
C6Y56_RS10745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6Y56_RS10750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6Y56_RS10755	COG2080	2 iron, 2 sulfur cluster binding
C6Y56_RS10775	COG5507	3-demethylubiquinone-9 3-methyltransferase
C6Y56_RS10785	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C6Y56_RS10795	COG1177	transmembrane transport
C6Y56_RS10800	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y56_RS10805	COG3842	ATPase activity
C6Y56_RS10810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6Y56_RS10815	COG0174	glutamine synthetase
C6Y56_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS10825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS10830	COG1396	sequence-specific DNA binding
C6Y56_RS10830	COG1917	Cupin 2, conserved barrel domain protein
C6Y56_RS10870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6Y56_RS10885	COG1566	PFAM secretion protein HlyD family protein
C6Y56_RS10900	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6Y56_RS10905	COG0583	DNA-binding transcription factor activity
C6Y56_RS10920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS10925	COG0174	glutamine synthetase
C6Y56_RS10940	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6Y56_RS10950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6Y56_RS10955	COG0583	DNA-binding transcription factor activity
C6Y56_RS10960	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6Y56_RS10965	COG0303	'Molybdopterin
C6Y56_RS10970	COG3791	Glutathione-dependent formaldehyde-activating
C6Y56_RS10975	COG0583	DNA-binding transcription factor activity
C6Y56_RS10995	COG2169	Transcriptional regulator
C6Y56_RS10995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6Y56_RS11015	COG4251	negative regulation of phosphorylation
C6Y56_RS11060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6Y56_RS11065	COG5001	Diguanylate cyclase
C6Y56_RS11065	COG5002	protein histidine kinase activity
C6Y56_RS11065	COG3447	MASE1 domain protein
C6Y56_RS11095	COG0583	DNA-binding transcription factor activity
C6Y56_RS11105	COG4172	Belongs to the ABC transporter superfamily
C6Y56_RS11110	COG4239	(ABC) transporter, permease
C6Y56_RS11115	COG4174	ABC transporter (Permease)
C6Y56_RS11120	COG4166	transmembrane transport
C6Y56_RS11125	COG4166	transmembrane transport
C6Y56_RS11130	COG1388	LysM domain
C6Y56_RS11130	COG0741	lytic transglycosylase activity
C6Y56_RS11135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y56_RS11145	COG0328	RNA-DNA hybrid ribonuclease activity
C6Y56_RS11150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y56_RS11155	COG1982	Orn Lys Arg decarboxylase major
C6Y56_RS11175	COG0431	NADPH-dependent FMN reductase
C6Y56_RS11180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C6Y56_RS11190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6Y56_RS11195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6Y56_RS11200	COG0705	Rhomboid family
C6Y56_RS11205	COG3139	Protein of unknown function (DUF1315)
C6Y56_RS11215	COG0308	aminopeptidase N
C6Y56_RS11220	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C6Y56_RS11225	COG4206	TonB-dependent receptor
C6Y56_RS11245	COG1999	signal sequence binding
C6Y56_RS11280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS11285	COG1136	(ABC) transporter
C6Y56_RS11285	COG0577	efflux transmembrane transporter activity
C6Y56_RS11295	COG0247	lactate metabolic process
C6Y56_RS11300	COG0277	FAD linked oxidase domain protein
C6Y56_RS11305	COG0277	FAD linked oxidase domain protein
C6Y56_RS11310	COG0625	glutathione transferase activity
C6Y56_RS11325	COG0765	amino acid transport
C6Y56_RS11330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS11340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y56_RS11345	COG0500	methyltransferase
C6Y56_RS11350	COG5001	Diguanylate cyclase
C6Y56_RS11350	COG3706	GGDEF domain
C6Y56_RS11350	COG4251	negative regulation of phosphorylation
C6Y56_RS11350	COG2203	Gaf domain
C6Y56_RS11355	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS11365	COG1309	transcriptional regulator
C6Y56_RS11370	COG2207	Transcriptional regulator
C6Y56_RS11375	COG0300	oxidoreductase activity
C6Y56_RS11380	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C6Y56_RS11390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C6Y56_RS11395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6Y56_RS11395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6Y56_RS11415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C6Y56_RS11420	COG1595	DNA-templated transcription, initiation
C6Y56_RS11460	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS11465	COG2010	Cytochrome c
C6Y56_RS11465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6Y56_RS11470	COG2080	2 iron, 2 sulfur cluster binding
C6Y56_RS11475	COG2010	Cytochrome c
C6Y56_RS11475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6Y56_RS11480	COG2814	Major facilitator Superfamily
C6Y56_RS11485	COG0583	DNA-binding transcription factor activity
C6Y56_RS11510	COG3251	PFAM MbtH domain protein
C6Y56_RS11515	COG2175	clavaminate synthase activity
C6Y56_RS11545	COG1064	alcohol dehydrogenase
C6Y56_RS11555	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y56_RS11575	COG1984	allophanate hydrolase subunit 2
C6Y56_RS11600	COG3158	transport of potassium into the cell
C6Y56_RS11625	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C6Y56_RS11635	COG1944	ATP diphosphatase activity
C6Y56_RS11645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y56_RS11665	COG4251	negative regulation of phosphorylation
C6Y56_RS11665	COG3706	GGDEF domain
C6Y56_RS11665	COG2203	Gaf domain
C6Y56_RS11665	COG5001	Diguanylate cyclase
C6Y56_RS11670	COG1335	isochorismatase
C6Y56_RS11695	COG4214	carbohydrate transport
C6Y56_RS11700	COG1129	ABC transporter
C6Y56_RS11705	COG4213	ABC transporter substrate-binding protein
C6Y56_RS11710	COG2115	Belongs to the xylose isomerase family
C6Y56_RS11715	COG1609	Transcriptional regulator
C6Y56_RS11715	COG2207	Transcriptional regulator
C6Y56_RS11730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y56_RS11735	COG3938	Belongs to the proline racemase family
C6Y56_RS11740	COG0531	amino acid
C6Y56_RS11795	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y56_RS11800	COG4829	muconolactone delta-isomerase
C6Y56_RS11805	COG3485	protocatechuate 3,4-dioxygenase
C6Y56_RS11815	COG3501	Rhs element vgr protein
C6Y56_RS11820	COG3209	COG3209 Rhs family protein
C6Y56_RS11850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6Y56_RS11855	COG2011	ABC-type metal ion transport system permease component
C6Y56_RS11920	COG0583	DNA-binding transcription factor activity
C6Y56_RS11925	COG0066	3-isopropylmalate dehydratase activity
C6Y56_RS11930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6Y56_RS11935	COG0251	oxidation-reduction process
C6Y56_RS11955	COG0251	oxidation-reduction process
C6Y56_RS11975	COG0642	Histidine kinase
C6Y56_RS11980	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS12010	COG0477	Major facilitator Superfamily
C6Y56_RS12025	COG2274	protein secretion by the type I secretion system
C6Y56_RS12030	COG0826	peptidase U32
C6Y56_RS12045	COG4638	Rieske (2fe-2S)
C6Y56_RS12055	COG0583	DNA-binding transcription factor activity
C6Y56_RS12060	COG4175	Glycine betaine
C6Y56_RS12065	COG4176	ABC-type proline glycine betaine transport system permease component
C6Y56_RS12070	COG2113	Glycine betaine
C6Y56_RS12085	COG2271	Major facilitator Superfamily
C6Y56_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS12105	COG0596	Alpha beta hydrolase
C6Y56_RS12135	COG2384	SAM-dependent methyltransferase
C6Y56_RS12150	COG1196	nuclear chromosome segregation
C6Y56_RS12150	COG3264	Mechanosensitive ion channel
C6Y56_RS12155	COG0431	NADPH-dependent FMN reductase
C6Y56_RS12160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6Y56_RS12165	COG0640	Transcriptional regulator
C6Y56_RS12190	COG2207	Transcriptional regulator
C6Y56_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS12215	COG4221	oxidoreductase activity
C6Y56_RS12220	COG1846	Transcriptional regulator
C6Y56_RS12220	COG0456	acetyltransferase
C6Y56_RS12280	COG2267	carboxylic ester hydrolase activity
C6Y56_RS12295	COG0583	DNA-binding transcription factor activity
C6Y56_RS12300	COG0656	L-ascorbic acid biosynthetic process
C6Y56_RS12315	COG1566	PFAM secretion protein HlyD family protein
C6Y56_RS12345	COG3046	protein related to deoxyribodipyrimidine photolyase
C6Y56_RS12380	COG1074	ATP-dependent DNA helicase activity
C6Y56_RS12395	COG3639	organic phosphonate transmembrane transporter activity
C6Y56_RS12400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6Y56_RS12405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C6Y56_RS12415	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS12420	COG2995	paraquat-inducible protein a
C6Y56_RS12435	COG0583	DNA-binding transcription factor activity
C6Y56_RS12455	COG1764	response to oxidative stress
C6Y56_RS12465	COG1063	alcohol dehydrogenase
C6Y56_RS12480	COG0589	response to stress
C6Y56_RS12500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y56_RS12505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6Y56_RS12515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y56_RS12535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C6Y56_RS12540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6Y56_RS12550	COG0589	response to stress
C6Y56_RS12595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6Y56_RS12595	COG1796	DNA polymerase
C6Y56_RS12615	COG0459	protein refolding
C6Y56_RS12620	COG0589	response to stress
C6Y56_RS12635	COG1136	(ABC) transporter
C6Y56_RS12655	COG0071	Belongs to the small heat shock protein (HSP20) family
C6Y56_RS12665	COG1132	(ABC) transporter
C6Y56_RS12685	COG0583	DNA-binding transcription factor activity
C6Y56_RS12855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6Y56_RS12985	COG3179	chitinase
C6Y56_RS13025	COG1522	sequence-specific DNA binding
C6Y56_RS13030	COG0697	spore germination
C6Y56_RS13070	COG0811	peptide transport
C6Y56_RS13100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y56_RS13125	COG3278	Belongs to the heme-copper respiratory oxidase family
C6Y56_RS13130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y56_RS13150	COG3795	YCII-related domain
C6Y56_RS13170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y56_RS13175	COG1538	Outer membrane efflux protein
C6Y56_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS13190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS13195	COG0348	domain, Protein
C6Y56_RS13205	COG1285	pathogenesis
C6Y56_RS13225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6Y56_RS13235	COG3568	Endonuclease Exonuclease Phosphatase
C6Y56_RS13285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6Y56_RS13290	COG0297	glycogen (starch) synthase activity
C6Y56_RS13295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y56_RS13300	COG0596	Alpha beta hydrolase
C6Y56_RS13305	COG1238	metal cluster binding
C6Y56_RS13365	COG2366	antibiotic biosynthetic process
C6Y56_RS13400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y56_RS13415	COG2233	PERMEase
C6Y56_RS13430	COG0010	Belongs to the arginase family
C6Y56_RS13445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y56_RS13470	COG2194	sulfuric ester hydrolase activity
C6Y56_RS13480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6Y56_RS13485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6Y56_RS13490	COG0561	phosphatase activity
C6Y56_RS13495	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6Y56_RS13510	COG2204	response regulator
C6Y56_RS13555	COG0840	transmembrane signaling receptor activity
C6Y56_RS13560	COG1968	undecaprenyl-diphosphatase activity
C6Y56_RS13580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6Y56_RS13595	COG0488	(ABC) transporter
C6Y56_RS13610	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C6Y56_RS13620	COG2133	pyrroloquinoline quinone binding
C6Y56_RS13635	COG0598	Magnesium transport protein CorA
C6Y56_RS13645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y56_RS13650	COG4574	serine-type endopeptidase inhibitor activity
C6Y56_RS13700	COG3501	Rhs element vgr protein
C6Y56_RS13720	COG1070	Carbohydrate kinase
C6Y56_RS13725	COG0246	Mannitol dehydrogenase
C6Y56_RS13740	COG1175	transmembrane transport
C6Y56_RS13775	COG2205	protein histidine kinase activity
C6Y56_RS13775	COG0784	Response regulator, receiver
C6Y56_RS13780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C6Y56_RS13790	COG2205	protein histidine kinase activity
C6Y56_RS13790	COG2198	Histidine kinase
C6Y56_RS13790	COG0784	Response regulator, receiver
C6Y56_RS13805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C6Y56_RS13825	COG1566	PFAM secretion protein HlyD family protein
C6Y56_RS13845	COG3152	Membrane
C6Y56_RS13855	COG2814	Major facilitator Superfamily
C6Y56_RS13865	COG0604	alcohol dehydrogenase
C6Y56_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS13865	COG3321	synthase
C6Y56_RS13875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS13890	COG0210	DNA helicase
C6Y56_RS13905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS13955	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C6Y56_RS13960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C6Y56_RS13960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C6Y56_RS13980	COG1199	ATP-dependent helicase activity
C6Y56_RS13980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y56_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS14010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6Y56_RS14020	COG0437	4 iron, 4 sulfur cluster binding
C6Y56_RS14025	COG2864	formate dehydrogenase
C6Y56_RS14030	COG3058	Necessary for formate dehydrogenase activity
C6Y56_RS14035	COG1921	L-seryl-tRNASec selenium transferase activity
C6Y56_RS14040	COG3276	selenocysteine insertion sequence binding
C6Y56_RS14065	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS14115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS14120	COG0747	negative chemotaxis
C6Y56_RS14125	COG0601	transmembrane transport
C6Y56_RS14130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y56_RS14150	COG2022	thiamine diphosphate biosynthetic process
C6Y56_RS14150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS14160	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS14165	COG0473	3-isopropylmalate dehydrogenase activity
C6Y56_RS14170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y56_RS14175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6Y56_RS14185	COG1522	sequence-specific DNA binding
C6Y56_RS14205	COG4175	Glycine betaine
C6Y56_RS14205	COG0517	IMP dehydrogenase activity
C6Y56_RS14220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y56_RS14235	COG2205	protein histidine kinase activity
C6Y56_RS14235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS14240	COG2197	response regulator
C6Y56_RS14250	COG3539	Fimbrial protein
C6Y56_RS14255	COG3121	Chaperone
C6Y56_RS14260	COG3188	usher protein
C6Y56_RS14300	COG2197	response regulator
C6Y56_RS14305	COG2205	protein histidine kinase activity
C6Y56_RS14305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS14310	COG3706	GGDEF domain
C6Y56_RS14310	COG5001	Diguanylate cyclase
C6Y56_RS14310	COG4251	negative regulation of phosphorylation
C6Y56_RS14310	COG2203	Gaf domain
C6Y56_RS14320	COG3188	usher protein
C6Y56_RS14325	COG3121	Chaperone
C6Y56_RS14365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS14375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6Y56_RS14445	COG1595	DNA-templated transcription, initiation
C6Y56_RS14460	COG0174	glutamine synthetase
C6Y56_RS14470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS14475	COG3008	intermembrane lipid transfer
C6Y56_RS14485	COG0642	Histidine kinase
C6Y56_RS14495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6Y56_RS14500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6Y56_RS14515	COG3842	ATPase activity
C6Y56_RS14520	COG4974	Belongs to the 'phage' integrase family
C6Y56_RS14525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6Y56_RS14530	COG0463	Glycosyl transferase, family 2
C6Y56_RS14535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6Y56_RS14535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y56_RS14540	COG0726	polysaccharide deacetylase
C6Y56_RS14545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C6Y56_RS14550	COG2076	Multidrug Resistance protein
C6Y56_RS14555	COG2076	Multidrug Resistance protein
C6Y56_RS14580	COG0165	Argininosuccinate lyase
C6Y56_RS14585	COG0765	amino acid transport
C6Y56_RS14615	COG2814	Major facilitator Superfamily
C6Y56_RS14630	COG1024	Enoyl-CoA hydratase
C6Y56_RS14635	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS14640	COG1024	Enoyl-CoA hydratase
C6Y56_RS14645	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS14650	COG0183	Belongs to the thiolase family
C6Y56_RS14660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y56_RS14665	COG2207	Transcriptional regulator
C6Y56_RS14670	COG0672	)-iron permease
C6Y56_RS14675	COG2822	iron ion transport
C6Y56_RS14685	COG2822	iron ion transport
C6Y56_RS14690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y56_RS14715	COG2816	NAD+ diphosphatase activity
C6Y56_RS14720	COG1024	Enoyl-CoA hydratase
C6Y56_RS14735	COG1595	DNA-templated transcription, initiation
C6Y56_RS14750	COG1335	isochorismatase
C6Y56_RS14755	COG2205	protein histidine kinase activity
C6Y56_RS14760	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS14765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS14780	COG1609	Transcriptional regulator
C6Y56_RS14790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y56_RS14815	COG1929	Belongs to the glycerate kinase type-1 family
C6Y56_RS14820	COG3835	regulator
C6Y56_RS14825	COG2271	Major facilitator Superfamily
C6Y56_RS14845	COG0583	DNA-binding transcription factor activity
C6Y56_RS14850	COG0667	Aldo Keto reductase
C6Y56_RS14855	COG2962	Rard protein
C6Y56_RS14870	COG0583	DNA-binding transcription factor activity
C6Y56_RS14895	COG3634	alkyl hydroperoxide reductase activity
C6Y56_RS14970	COG2169	Transcriptional regulator
C6Y56_RS14970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6Y56_RS14975	COG0604	alcohol dehydrogenase
C6Y56_RS14995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C6Y56_RS15005	COG0488	(ABC) transporter
C6Y56_RS15025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6Y56_RS15025	COG2755	lipolytic protein G-D-S-L family
C6Y56_RS15055	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS15065	COG2267	carboxylic ester hydrolase activity
C6Y56_RS15070	COG0604	alcohol dehydrogenase
C6Y56_RS15070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6Y56_RS15070	COG3321	synthase
C6Y56_RS15070	COG4221	oxidoreductase activity
C6Y56_RS15080	COG2207	Transcriptional regulator
C6Y56_RS15120	COG0322	excinuclease ABC activity
C6Y56_RS15125	COG2197	response regulator
C6Y56_RS15135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6Y56_RS15145	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C6Y56_RS15150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y56_RS15155	COG4166	transmembrane transport
C6Y56_RS15160	COG4174	ABC transporter (Permease)
C6Y56_RS15165	COG4239	(ABC) transporter, permease
C6Y56_RS15170	COG4172	Belongs to the ABC transporter superfamily
C6Y56_RS15180	COG2610	gluconate transmembrane transporter activity
C6Y56_RS15185	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS15190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y56_RS15205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y56_RS15210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y56_RS15235	COG0765	amino acid transport
C6Y56_RS15240	COG0765	amino acid transport
C6Y56_RS15245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS15255	COG1253	flavin adenine dinucleotide binding
C6Y56_RS15260	COG0789	Transcriptional regulator
C6Y56_RS15325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C6Y56_RS15325	COG0316	Belongs to the HesB IscA family
C6Y56_RS15330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6Y56_RS15365	COG0616	signal peptide processing
C6Y56_RS15380	COG4172	Belongs to the ABC transporter superfamily
C6Y56_RS15385	COG4239	(ABC) transporter, permease
C6Y56_RS15390	COG4174	ABC transporter (Permease)
C6Y56_RS15395	COG4166	transmembrane transport
C6Y56_RS15400	COG4771	TonB-dependent receptor
C6Y56_RS15405	COG4206	TonB-dependent receptor
C6Y56_RS15415	COG1595	DNA-templated transcription, initiation
C6Y56_RS15420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6Y56_RS15420	COG1024	Enoyl-CoA hydratase
C6Y56_RS15455	COG1366	Belongs to the anti-sigma-factor antagonist family
C6Y56_RS15460	COG1366	Belongs to the anti-sigma-factor antagonist family
C6Y56_RS15465	COG2172	sigma factor antagonist activity
C6Y56_RS15490	COG4191	Histidine kinase
C6Y56_RS15490	COG0784	Response regulator, receiver
C6Y56_RS15510	COG0587	DNA-directed DNA polymerase activity
C6Y56_RS15525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6Y56_RS15545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y56_RS15560	COG2081	HI0933 family
C6Y56_RS15565	COG2188	Transcriptional regulator
C6Y56_RS15570	COG0673	inositol 2-dehydrogenase activity
C6Y56_RS15655	COG1609	Transcriptional regulator
C6Y56_RS15665	COG1175	transmembrane transport
C6Y56_RS15670	COG1177	transmembrane transport
C6Y56_RS15675	COG3842	ATPase activity
C6Y56_RS15680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6Y56_RS15785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y56_RS15820	COG0714	Associated with various cellular activities
C6Y56_RS15850	COG0420	3'-5' exonuclease activity
C6Y56_RS15880	COG2706	6-phosphogluconolactonase activity
C6Y56_RS15890	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS15930	COG2267	carboxylic ester hydrolase activity
C6Y56_RS15935	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS15945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y56_RS15950	COG2186	Transcriptional regulator
C6Y56_RS15970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6Y56_RS15980	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y56_RS15990	COG3842	ATPase activity
C6Y56_RS15995	COG0024	Methionine aminopeptidase
C6Y56_RS16005	COG0248	Ppx GppA phosphatase
C6Y56_RS16015	COG0626	cystathionine gamma-synthase activity
C6Y56_RS16035	COG2198	Histidine kinase
C6Y56_RS16035	COG2205	protein histidine kinase activity
C6Y56_RS16035	COG0784	Response regulator, receiver
C6Y56_RS16050	COG2207	Transcriptional regulator
C6Y56_RS16055	COG0154	amidase activity
C6Y56_RS16060	COG2837	iron assimilation
C6Y56_RS16065	COG0861	Integral membrane protein TerC family
C6Y56_RS16075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6Y56_RS16085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y56_RS16105	COG2072	flavoprotein involved in K transport
C6Y56_RS16125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6Y56_RS16130	COG0625	glutathione transferase activity
C6Y56_RS16140	COG0583	DNA-binding transcription factor activity
C6Y56_RS16145	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS16150	COG0477	Major facilitator Superfamily
C6Y56_RS16155	COG0583	DNA-binding transcription factor activity
C6Y56_RS16165	COG0247	lactate metabolic process
C6Y56_RS16165	COG0277	FAD linked oxidase domain protein
C6Y56_RS16170	COG0583	DNA-binding transcription factor activity
C6Y56_RS16190	COG0494	nUDIX hydrolase
C6Y56_RS16205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y56_RS16215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y56_RS16220	COG2135	peptidase activity
C6Y56_RS16255	COG1611	Belongs to the LOG family
C6Y56_RS16290	COG2111	Na H antiporter
C6Y56_RS16290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6Y56_RS16295	COG1006	Multisubunit Na H antiporter MnhC subunit
C6Y56_RS16300	COG0651	ATP synthesis coupled electron transport
C6Y56_RS16310	COG2212	antiporter activity
C6Y56_RS16315	COG1320	monovalent cation:proton antiporter activity
C6Y56_RS16330	COG4774	siderophore transport
C6Y56_RS16375	COG4335	DNA alkylation repair
C6Y56_RS16380	COG1280	lysine exporter protein (LysE YggA)
C6Y56_RS16425	COG3038	cytochrome b561
C6Y56_RS16435	COG1022	Amp-dependent synthetase and ligase
C6Y56_RS16455	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS16490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y56_RS16510	COG0662	Cupin 2, conserved barrel domain protein
C6Y56_RS16520	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C6Y56_RS16525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6Y56_RS16545	COG0583	DNA-binding transcription factor activity
C6Y56_RS16550	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C6Y56_RS16560	COG0288	reversible hydration of carbon dioxide
C6Y56_RS16570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6Y56_RS16575	COG2066	Belongs to the glutaminase family
C6Y56_RS16585	COG2259	Doxx family
C6Y56_RS16615	COG2814	Major facilitator Superfamily
C6Y56_RS16640	COG1294	oxidase, subunit
C6Y56_RS16645	COG1271	oxidase subunit
C6Y56_RS16655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6Y56_RS16660	COG3781	membrane
C6Y56_RS16665	COG2205	protein histidine kinase activity
C6Y56_RS16670	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS16680	COG0589	response to stress
C6Y56_RS16705	COG0814	amino acid
C6Y56_RS16715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y56_RS16790	COG3501	Rhs element vgr protein
C6Y56_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS16845	COG1953	Uracil, thiamine, allantoin
C6Y56_RS16865	COG1309	transcriptional regulator
C6Y56_RS16910	COG0640	Transcriptional regulator
C6Y56_RS16925	COG1522	sequence-specific DNA binding
C6Y56_RS16930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6Y56_RS16935	COG0022	dehydrogenase e1 component
C6Y56_RS16945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y56_RS16950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6Y56_RS16970	COG2124	cytochrome p450
C6Y56_RS16975	COG1230	cation diffusion facilitator family transporter
C6Y56_RS17045	COG0583	DNA-binding transcription factor activity
C6Y56_RS17055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS17060	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y56_RS17090	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS17095	COG5002	protein histidine kinase activity
C6Y56_RS17105	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS17115	COG0583	DNA-binding transcription factor activity
C6Y56_RS17125	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6Y56_RS17135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6Y56_RS17145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C6Y56_RS17165	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6Y56_RS17205	COG0534	Mate efflux family protein
C6Y56_RS17230	COG3474	cytochrome
C6Y56_RS17235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS17240	COG0697	spore germination
C6Y56_RS17255	COG0659	secondary active sulfate transmembrane transporter activity
C6Y56_RS17265	COG0456	acetyltransferase
C6Y56_RS17280	COG1335	isochorismatase
C6Y56_RS17295	COG0494	nUDIX hydrolase
C6Y56_RS17300	COG3469	chitinase activity
C6Y56_RS17315	COG0454	-acetyltransferase
C6Y56_RS17355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6Y56_RS17360	COG0435	Glutathione S-transferase
C6Y56_RS17365	COG1648	precorrin-2 dehydrogenase activity
C6Y56_RS17365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6Y56_RS17370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6Y56_RS17375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6Y56_RS17380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6Y56_RS17385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C6Y56_RS17390	COG1674	ftsk spoiiie
C6Y56_RS17395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6Y56_RS17400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C6Y56_RS17405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6Y56_RS17410	COG0542	response to heat
C6Y56_RS17415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6Y56_RS17420	COG1278	Cold shock
C6Y56_RS17440	COG0482	sulfurtransferase activity
C6Y56_RS17445	COG2915	High frequency lysogenization protein hflD homolog
C6Y56_RS17455	COG2850	peptidyl-arginine hydroxylation
C6Y56_RS17460	COG2153	protein acetylation
C6Y56_RS17470	COG2224	Isocitrate lyase
C6Y56_RS17475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y56_RS17480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y56_RS17485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y56_RS17485	COG0649	NAD binding
C6Y56_RS17500	COG1034	ATP synthesis coupled electron transport
C6Y56_RS17505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6Y56_RS17510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y56_RS17520	COG0713	ATP synthesis coupled electron transport
C6Y56_RS17605	COG0395	ABC-type sugar transport system, permease component
C6Y56_RS17615	COG3842	ATPase activity
C6Y56_RS17620	COG3842	ATPase activity
C6Y56_RS17625	COG3284	Transcriptional regulator
C6Y56_RS17630	COG1968	undecaprenyl-diphosphatase activity
C6Y56_RS17635	COG0215	cysteine-tRNA ligase activity
C6Y56_RS17640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y56_RS17650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y56_RS17655	COG2814	Major facilitator Superfamily
C6Y56_RS17660	COG1566	PFAM secretion protein HlyD family protein
C6Y56_RS17670	COG1846	Transcriptional regulator
C6Y56_RS17675	COG2911	Protein conserved in bacteria
C6Y56_RS17680	COG0729	surface antigen
C6Y56_RS17690	COG0708	Exodeoxyribonuclease III
C6Y56_RS17695	COG2885	chlorophyll binding
C6Y56_RS17700	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS17710	COG0789	Transcriptional regulator
C6Y56_RS17720	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y56_RS17725	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS17730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6Y56_RS17735	COG1024	Enoyl-CoA hydratase
C6Y56_RS17745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6Y56_RS17760	COG2866	Carboxypeptidase
C6Y56_RS17765	COG2814	Major facilitator Superfamily
C6Y56_RS17770	COG3038	cytochrome b561
C6Y56_RS17795	COG1595	DNA-templated transcription, initiation
C6Y56_RS17840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y56_RS17845	COG0515	serine threonine protein kinase
C6Y56_RS17850	COG0217	transcriptional regulatory protein
C6Y56_RS17855	COG3501	Rhs element vgr protein
C6Y56_RS17860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS17865	COG2271	Major facilitator Superfamily
C6Y56_RS17870	COG0583	DNA-binding transcription factor activity
C6Y56_RS17875	COG0583	DNA-binding transcription factor activity
C6Y56_RS17880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6Y56_RS17885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6Y56_RS17900	COG3038	cytochrome b561
C6Y56_RS17910	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS17910	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y56_RS17930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y56_RS17935	COG0776	regulation of translation
C6Y56_RS17940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6Y56_RS17945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6Y56_RS17950	COG0740	serine-type endopeptidase activity
C6Y56_RS17955	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6Y56_RS17980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6Y56_RS17985	COG1686	Belongs to the peptidase S11 family
C6Y56_RS18005	COG1253	flavin adenine dinucleotide binding
C6Y56_RS18015	COG0583	DNA-binding transcription factor activity
C6Y56_RS18025	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C6Y56_RS18035	COG3132	Protein of unknown function, DUF480
C6Y56_RS18045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6Y56_RS18075	COG0583	DNA-binding transcription factor activity
C6Y56_RS18080	COG0697	spore germination
C6Y56_RS18085	COG1609	Transcriptional regulator
C6Y56_RS18125	COG0730	response to heat
C6Y56_RS18190	COG3501	Rhs element vgr protein
C6Y56_RS18200	COG0656	L-ascorbic acid biosynthetic process
C6Y56_RS18210	COG0417	DNA replication proofreading
C6Y56_RS18215	COG0517	IMP dehydrogenase activity
C6Y56_RS18245	COG4166	transmembrane transport
C6Y56_RS18250	COG4174	ABC transporter (Permease)
C6Y56_RS18255	COG4239	(ABC) transporter, permease
C6Y56_RS18260	COG4172	Belongs to the ABC transporter superfamily
C6Y56_RS18310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6Y56_RS18320	COG0113	porphobilinogen synthase activity
C6Y56_RS18325	COG0625	glutathione transferase activity
C6Y56_RS18335	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C6Y56_RS18365	COG1063	alcohol dehydrogenase
C6Y56_RS18420	COG2056	Na+-H+ antiporter family
C6Y56_RS18425	COG0840	transmembrane signaling receptor activity
C6Y56_RS18430	COG2205	protein histidine kinase activity
C6Y56_RS18435	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS18455	COG0720	synthase
C6Y56_RS18465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6Y56_RS18470	COG0402	S-adenosylhomocysteine deaminase activity
C6Y56_RS18480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6Y56_RS18485	COG2223	nitrite transmembrane transporter activity
C6Y56_RS18495	COG4772	TonB-dependent receptor
C6Y56_RS18505	COG1595	DNA-templated transcription, initiation
C6Y56_RS18550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y56_RS18555	COG1595	DNA-templated transcription, initiation
C6Y56_RS18560	COG3712	iron ion homeostasis
C6Y56_RS18570	COG3706	GGDEF domain
C6Y56_RS18570	COG4251	negative regulation of phosphorylation
C6Y56_RS18570	COG2203	Gaf domain
C6Y56_RS18570	COG5001	Diguanylate cyclase
C6Y56_RS18585	COG0583	DNA-binding transcription factor activity
C6Y56_RS18610	COG2132	Multicopper oxidase
C6Y56_RS18725	COG3179	chitinase
C6Y56_RS18830	COG0616	signal peptide processing
C6Y56_RS18890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6Y56_RS18950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6Y56_RS18960	COG1968	undecaprenyl-diphosphatase activity
C6Y56_RS18975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6Y56_RS18980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6Y56_RS19005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6Y56_RS19065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6Y56_RS19075	COG2204	response regulator
C6Y56_RS19095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C6Y56_RS19095	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C6Y56_RS19115	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6Y56_RS19120	COG1136	(ABC) transporter
C6Y56_RS19125	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6Y56_RS19135	COG0584	glycerophosphoryl diester phosphodiesterase
C6Y56_RS19140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y56_RS19145	COG1477	protein flavinylation
C6Y56_RS19160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6Y56_RS19170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6Y56_RS19175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6Y56_RS19220	COG0183	Belongs to the thiolase family
C6Y56_RS19225	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y56_RS19225	COG1024	Enoyl-CoA hydratase
C6Y56_RS19235	COG0589	response to stress
C6Y56_RS19245	COG0741	lytic transglycosylase activity
C6Y56_RS19250	COG1132	(ABC) transporter
C6Y56_RS19260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y56_RS19270	COG0425	Belongs to the sulfur carrier protein TusA family
C6Y56_RS19275	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C6Y56_RS19295	COG1397	ADP-ribosylglycohydrolase
C6Y56_RS19345	COG1404	Belongs to the peptidase S8 family
C6Y56_RS19350	COG1132	(ABC) transporter
C6Y56_RS19370	COG0477	Major facilitator Superfamily
C6Y56_RS19375	COG0583	DNA-binding transcription factor activity
C6Y56_RS19380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y56_RS19385	COG0235	Class ii aldolase
C6Y56_RS19390	COG0477	Major facilitator Superfamily
C6Y56_RS19395	COG0583	DNA-binding transcription factor activity
C6Y56_RS19400	COG0768	penicillin binding
C6Y56_RS19445	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS19460	COG0583	DNA-binding transcription factor activity
C6Y56_RS19485	COG0431	NADPH-dependent FMN reductase
C6Y56_RS19490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y56_RS19500	COG3829	transcription factor binding
C6Y56_RS19520	COG0596	Alpha beta hydrolase
C6Y56_RS19550	COG1121	(ABC) transporter
C6Y56_RS19555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6Y56_RS19580	COG0642	Histidine kinase
C6Y56_RS19595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6Y56_RS19610	COG2267	carboxylic ester hydrolase activity
C6Y56_RS19635	COG1309	transcriptional regulator
C6Y56_RS19650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6Y56_RS19655	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS19660	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y56_RS19660	COG1024	Enoyl-CoA hydratase
C6Y56_RS19675	COG3123	guanosine phosphorylase activity
C6Y56_RS19695	COG3851	Histidine kinase
C6Y56_RS19700	COG2197	response regulator
C6Y56_RS19705	COG1597	lipid kinase activity
C6Y56_RS19715	COG0303	'Molybdopterin
C6Y56_RS19720	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6Y56_RS19725	COG0746	molybdenum cofactor guanylyltransferase activity
C6Y56_RS19735	COG0564	pseudouridine synthase activity
C6Y56_RS19755	COG0004	ammonium transporteR
C6Y56_RS19785	COG2197	response regulator
C6Y56_RS19790	COG2205	protein histidine kinase activity
C6Y56_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS19795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C6Y56_RS19800	COG1956	GAF domain-containing protein
C6Y56_RS19810	COG5002	protein histidine kinase activity
C6Y56_RS19810	COG0784	Response regulator, receiver
C6Y56_RS19810	COG2205	protein histidine kinase activity
C6Y56_RS19815	COG1846	Transcriptional regulator
C6Y56_RS19820	COG0386	Belongs to the glutathione peroxidase family
C6Y56_RS19825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y56_RS19830	COG0436	Aminotransferase
C6Y56_RS19835	COG0501	Belongs to the peptidase M48B family
C6Y56_RS19840	COG0500	methyltransferase
C6Y56_RS19845	COG3384	dioxygenase
C6Y56_RS19865	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6Y56_RS19870	COG3214	Protein conserved in bacteria
C6Y56_RS19880	COG0583	DNA-binding transcription factor activity
C6Y56_RS19890	COG0583	DNA-binding transcription factor activity
C6Y56_RS19895	COG1846	Transcriptional regulator
C6Y56_RS19900	COG1764	response to oxidative stress
C6Y56_RS19910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6Y56_RS19925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y56_RS19945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C6Y56_RS19975	COG1376	ErfK ybiS ycfS ynhG family protein
C6Y56_RS19990	COG4181	ATPase activity
C6Y56_RS19995	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C6Y56_RS20010	COG2259	Doxx family
C6Y56_RS20015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C6Y56_RS20020	COG0084	hydrolase, TatD family'
C6Y56_RS20060	COG2205	protein histidine kinase activity
C6Y56_RS20065	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C6Y56_RS20075	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C6Y56_RS20105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y56_RS20110	COG4221	oxidoreductase activity
C6Y56_RS20115	COG1555	photosystem II stabilization
C6Y56_RS20135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6Y56_RS20165	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS20180	COG1215	transferase activity, transferring glycosyl groups
C6Y56_RS20230	COG0776	regulation of translation
C6Y56_RS20245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6Y56_RS20250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6Y56_RS20255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6Y56_RS20265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6Y56_RS20275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C6Y56_RS20280	COG0402	S-adenosylhomocysteine deaminase activity
C6Y56_RS20285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y56_RS20290	COG0546	phosphoglycolate phosphatase activity
C6Y56_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS20300	COG3706	GGDEF domain
C6Y56_RS20310	COG5002	protein histidine kinase activity
C6Y56_RS20310	COG5001	Diguanylate cyclase
C6Y56_RS20335	COG0271	Belongs to the BolA IbaG family
C6Y56_RS20345	COG0114	fumarate hydratase activity
C6Y56_RS20350	COG0697	spore germination
C6Y56_RS20360	COG0183	Belongs to the thiolase family
C6Y56_RS20365	COG2326	polyphosphate kinase activity
C6Y56_RS20370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C6Y56_RS20370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS20380	COG0367	asparagine synthase
C6Y56_RS20385	COG0189	ligase activity
C6Y56_RS20385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y56_RS20395	COG3089	Belongs to the UPF0270 family
C6Y56_RS20400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C6Y56_RS20405	COG1742	UPF0060 membrane protein
C6Y56_RS20420	COG1368	sulfuric ester hydrolase activity
C6Y56_RS20440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS20445	COG2885	chlorophyll binding
C6Y56_RS20475	COG2207	Transcriptional regulator
C6Y56_RS20480	COG1064	alcohol dehydrogenase
C6Y56_RS20485	COG1414	Transcriptional regulator
C6Y56_RS20490	COG2271	Major facilitator Superfamily
C6Y56_RS20495	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y56_RS20500	COG0800	Aldolase
C6Y56_RS20505	COG3734	2-keto-3-deoxy-galactonokinase
C6Y56_RS20530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y56_RS20540	COG1397	ADP-ribosylglycohydrolase
C6Y56_RS20545	COG2188	Transcriptional regulator
C6Y56_RS20550	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6Y56_RS20555	COG1129	ABC transporter
C6Y56_RS20560	COG1879	ABC-type sugar transport system periplasmic component
C6Y56_RS20565	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS20575	COG2186	Transcriptional regulator
C6Y56_RS20590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6Y56_RS20600	COG0084	hydrolase, TatD family'
C6Y56_RS20615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6Y56_RS20620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6Y56_RS20630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y56_RS20635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y56_RS20650	COG0416	fatty acid biosynthetic process
C6Y56_RS20655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6Y56_RS20660	COG1399	metal-binding, possibly nucleic acid-binding protein
C6Y56_RS20665	COG0424	maF-like protein
C6Y56_RS20670	COG0616	signal peptide processing
C6Y56_RS20670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6Y56_RS20675	COG0546	phosphoglycolate phosphatase activity
C6Y56_RS20685	COG1530	ribonuclease E activity
C6Y56_RS20695	COG3608	succinylglutamate desuccinylase aspartoacylase
C6Y56_RS20695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6Y56_RS20710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6Y56_RS20715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6Y56_RS20720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C6Y56_RS20725	COG2835	tetraacyldisaccharide 4'-kinase activity
C6Y56_RS20730	COG1663	tetraacyldisaccharide 4'-kinase activity
C6Y56_RS20735	COG0848	biopolymer transport protein
C6Y56_RS20740	COG0811	peptide transport
C6Y56_RS20755	COG0842	Transport permease protein
C6Y56_RS20760	COG1131	(ABC) transporter
C6Y56_RS20765	COG0625	glutathione transferase activity
C6Y56_RS20775	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS20790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6Y56_RS20845	COG0840	transmembrane signaling receptor activity
C6Y56_RS20850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS20855	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS20860	COG2130	NADP-dependent
C6Y56_RS20865	COG0284	orotidine-5'-phosphate decarboxylase activity
C6Y56_RS20875	COG2205	protein histidine kinase activity
C6Y56_RS20885	COG0628	permease
C6Y56_RS20910	COG1022	Amp-dependent synthetase and ligase
C6Y56_RS20925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6Y56_RS20930	COG4771	TonB-dependent receptor
C6Y56_RS20940	COG2205	protein histidine kinase activity
C6Y56_RS20940	COG0784	Response regulator, receiver
C6Y56_RS20940	COG5002	protein histidine kinase activity
C6Y56_RS20945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y56_RS20960	COG3122	Protein conserved in bacteria
C6Y56_RS20965	COG3956	TIGRFAM MazG family protein
C6Y56_RS20970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6Y56_RS20975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6Y56_RS20995	COG5002	protein histidine kinase activity
C6Y56_RS20995	COG2205	protein histidine kinase activity
C6Y56_RS20995	COG0784	Response regulator, receiver
C6Y56_RS21000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y56_RS21020	COG3118	belongs to the thioredoxin family
C6Y56_RS21025	COG1393	Belongs to the ArsC family
C6Y56_RS21040	COG2818	Glycosylase
C6Y56_RS21045	COG0037	tRNA processing
C6Y56_RS21055	COG3091	SprT-like family
C6Y56_RS21060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y56_RS21065	COG1301	dicarboxylic acid transport
C6Y56_RS21070	COG4977	sequence-specific DNA binding
C6Y56_RS21070	COG1917	Cupin 2, conserved barrel domain protein
C6Y56_RS21075	COG2205	protein histidine kinase activity
C6Y56_RS21080	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS21095	COG2205	protein histidine kinase activity
C6Y56_RS21100	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS21105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6Y56_RS21105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6Y56_RS21110	COG1749	Flagellar hook protein flgE
C6Y56_RS21115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C6Y56_RS21125	COG1815	bacterial-type flagellum-dependent cell motility
C6Y56_RS21130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C6Y56_RS21135	COG0835	chemotaxis
C6Y56_RS21135	COG0784	Response regulator, receiver
C6Y56_RS21145	COG2747	anti-sigma28 factor FlgM
C6Y56_RS21155	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C6Y56_RS21160	COG0477	Major facilitator Superfamily
C6Y56_RS21185	COG0582	viral genome integration into host DNA
C6Y56_RS21330	COG2239	Acts as a magnesium transporter
C6Y56_RS21360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C6Y56_RS21365	COG0527	aspartate kinase activity
C6Y56_RS21370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6Y56_RS21375	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C6Y56_RS21380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6Y56_RS21385	COG2988	succinylglutamate desuccinylase activity
C6Y56_RS21395	COG3724	N-succinylarginine dihydrolase activity
C6Y56_RS21400	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS21415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6Y56_RS21455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y56_RS21465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6Y56_RS21515	COG3706	GGDEF domain
C6Y56_RS21535	COG0504	CTP synthase activity
C6Y56_RS21540	COG2329	Antibiotic biosynthesis monooxygenase
C6Y56_RS21550	COG0584	glycerophosphoryl diester phosphodiesterase
C6Y56_RS21575	COG0306	phosphate transporter
C6Y56_RS21580	COG0583	DNA-binding transcription factor activity
C6Y56_RS21585	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS21595	COG0583	DNA-binding transcription factor activity
C6Y56_RS21600	COG0583	DNA-binding transcription factor activity
C6Y56_RS21605	COG4221	oxidoreductase activity
C6Y56_RS21610	COG4941	Belongs to the sigma-70 factor family
C6Y56_RS21615	COG3795	YCII-related domain
C6Y56_RS21625	COG0456	acetyltransferase
C6Y56_RS21680	COG0436	Aminotransferase
C6Y56_RS21690	COG3265	gluconokinase activity
C6Y56_RS21695	COG1609	Transcriptional regulator
C6Y56_RS21700	COG0583	DNA-binding transcription factor activity
C6Y56_RS21710	COG2271	Major facilitator Superfamily
C6Y56_RS21750	COG0242	peptide deformylase activity
C6Y56_RS21755	COG1295	ribonuclease BN
C6Y56_RS21770	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y56_RS21785	COG2030	dehydratase
C6Y56_RS21795	COG3530	Putative quorum-sensing-regulated virulence factor
C6Y56_RS21810	COG0800	Aldolase
C6Y56_RS21825	COG1737	Transcriptional regulator
C6Y56_RS21830	COG0676	glucose-6-phosphate 1-epimerase activity
C6Y56_RS21840	COG3842	ATPase activity
C6Y56_RS21845	COG0395	ABC-type sugar transport system, permease component
C6Y56_RS21850	COG1175	transmembrane transport
C6Y56_RS21855	COG1653	transport
C6Y56_RS21865	COG2205	protein histidine kinase activity
C6Y56_RS21870	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS21895	COG3712	iron ion homeostasis
C6Y56_RS21900	COG4771	TonB-dependent receptor
C6Y56_RS21910	COG2832	Protein of unknown function (DUF454)
C6Y56_RS21915	COG0840	transmembrane signaling receptor activity
C6Y56_RS21920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y56_RS21940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6Y56_RS21960	COG0509	glycine decarboxylation via glycine cleavage system
C6Y56_RS21965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y56_RS21965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y56_RS21970	COG1760	l-serine dehydratase
C6Y56_RS21975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6Y56_RS21980	COG1278	Cold shock
C6Y56_RS21990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6Y56_RS22005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C6Y56_RS22010	COG0602	queuosine metabolic process
C6Y56_RS22015	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C6Y56_RS22020	COG2885	chlorophyll binding
C6Y56_RS22025	COG0823	Involved in the tonB-independent uptake of proteins
C6Y56_RS22045	COG0824	Thioesterase
C6Y56_RS22050	COG2255	four-way junction helicase activity
C6Y56_RS22055	COG0632	four-way junction helicase activity
C6Y56_RS22060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6Y56_RS22065	COG0217	transcriptional regulatory protein
C6Y56_RS22070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6Y56_RS22085	COG0783	Belongs to the Dps family
C6Y56_RS22095	COG2900	Belongs to the SlyX family
C6Y56_RS22110	COG0668	transmembrane transport
C6Y56_RS22115	COG1666	GTP binding
C6Y56_RS22130	COG2096	Adenosyltransferase
C6Y56_RS22135	COG0494	nUDIX hydrolase
C6Y56_RS22145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6Y56_RS22150	COG0653	protein targeting
C6Y56_RS22160	COG0433	COG0433 Predicted ATPase
C6Y56_RS22170	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS22170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6Y56_RS22200	COG2925	Exonuclease
C6Y56_RS22225	COG0714	Associated with various cellular activities
C6Y56_RS22255	COG0469	pyruvate kinase activity
C6Y56_RS22260	COG1024	Enoyl-CoA hydratase
C6Y56_RS22270	COG3706	GGDEF domain
C6Y56_RS22280	COG4191	Histidine kinase
C6Y56_RS22290	COG0477	Major facilitator Superfamily
C6Y56_RS22315	COG2207	Transcriptional regulator
C6Y56_RS22320	COG3842	ATPase activity
C6Y56_RS22340	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS22350	COG0583	DNA-binding transcription factor activity
C6Y56_RS22355	COG2910	NAD(P)H-binding
C6Y56_RS22365	COG0583	DNA-binding transcription factor activity
C6Y56_RS22385	COG0477	Major facilitator Superfamily
C6Y56_RS22400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y56_RS22405	COG0583	DNA-binding transcription factor activity
C6Y56_RS22420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6Y56_RS22450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS22455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y56_RS22465	COG3642	lipopolysaccharide core region biosynthetic process
C6Y56_RS22475	COG0642	Histidine kinase
C6Y56_RS22485	COG1368	sulfuric ester hydrolase activity
C6Y56_RS22495	COG0459	protein refolding
C6Y56_RS22500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6Y56_RS22515	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS22520	COG0489	protein tyrosine kinase activity
C6Y56_RS22525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y56_RS22525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y56_RS22535	COG2878	Part of a membrane complex involved in electron transport
C6Y56_RS22540	COG4658	electron transport chain
C6Y56_RS22545	COG4659	FMN binding
C6Y56_RS22555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6Y56_RS22565	COG2197	response regulator
C6Y56_RS22575	COG0137	argininosuccinate synthase activity
C6Y56_RS22585	COG0418	dihydroorotase activity
C6Y56_RS22590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y56_RS22595	COG0450	alkyl hydroperoxide reductase
C6Y56_RS22610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C6Y56_RS22615	COG0243	molybdopterin cofactor binding
C6Y56_RS22625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6Y56_RS22630	COG3842	ATPase activity
C6Y56_RS22640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6Y56_RS22650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6Y56_RS22665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS22670	COG0765	amino acid transport
C6Y56_RS22675	COG0765	amino acid transport
C6Y56_RS22680	COG1126	abc transporter atp-binding protein
C6Y56_RS22710	COG2076	Multidrug Resistance protein
C6Y56_RS22725	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C6Y56_RS22730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6Y56_RS22745	COG4191	Histidine kinase
C6Y56_RS22750	COG2204	response regulator
C6Y56_RS22755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y56_RS22765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C6Y56_RS22770	COG0583	DNA-binding transcription factor activity
C6Y56_RS22780	COG1280	lysine exporter protein (LysE YggA)
C6Y56_RS22785	COG0494	nUDIX hydrolase
C6Y56_RS22795	COG3300	MHYT domain
C6Y56_RS22795	COG5001	Diguanylate cyclase
C6Y56_RS22805	COG1858	cytochrome C peroxidase
C6Y56_RS22820	COG0531	amino acid
C6Y56_RS22830	COG2197	response regulator
C6Y56_RS22835	COG0069	glutamate synthase activity
C6Y56_RS22845	COG1113	amino acid transport
C6Y56_RS22890	COG1695	Transcriptional regulator
C6Y56_RS22895	COG2375	cellular response to nickel ion
C6Y56_RS22905	COG4628	conserved protein (DUF2132)
C6Y56_RS22925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6Y56_RS22945	COG4106	trans-aconitate 2-methyltransferase activity
C6Y56_RS22950	COG0500	methyltransferase
C6Y56_RS22955	COG0590	tRNA wobble adenosine to inosine editing
C6Y56_RS22970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y56_RS22970	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y56_RS22980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y56_RS22980	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y56_RS23005	COG1570	exodeoxyribonuclease VII activity
C6Y56_RS23010	COG0739	heme binding
C6Y56_RS23015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y56_RS23020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y56_RS23025	COG0436	Aminotransferase
C6Y56_RS23035	COG1160	GTP binding
C6Y56_RS23050	COG0124	histidyl-tRNA synthetase
C6Y56_RS23055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6Y56_RS23060	COG1426	Protein conserved in bacteria
C6Y56_RS23070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6Y56_RS23075	COG0105	UTP biosynthetic process
C6Y56_RS23085	COG0633	Ferredoxin
C6Y56_RS23090	COG0443	Heat shock 70 kDa protein
C6Y56_RS23095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6Y56_RS23100	COG0316	Belongs to the HesB IscA family
C6Y56_RS23110	COG1104	cysteine desulfurase activity
C6Y56_RS23135	COG3134	Outer membrane lipoprotein
C6Y56_RS23150	COG1862	Preprotein translocase
C6Y56_RS23155	COG0343	queuine tRNA-ribosyltransferase activity
C6Y56_RS23160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C6Y56_RS23170	COG0582	viral genome integration into host DNA
C6Y56_RS23265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6Y56_RS23270	COG0583	DNA-binding transcription factor activity
C6Y56_RS23275	COG1696	Membrane protein involved in D-alanine export
C6Y56_RS23290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y56_RS23305	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS23320	COG1213	nucleotidyl transferase
C6Y56_RS23325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6Y56_RS23330	COG0574	Belongs to the PEP-utilizing enzyme family
C6Y56_RS23330	COG3848	Pyruvate phosphate dikinase
C6Y56_RS23340	COG1183	phosphatidylcholine synthase activity
C6Y56_RS23350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS23370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6Y56_RS23375	COG1509	lysine 2,3-aminomutase activity
C6Y56_RS23380	COG0625	glutathione transferase activity
C6Y56_RS23405	COG2186	Transcriptional regulator
C6Y56_RS23410	COG0109	protoheme IX farnesyltransferase activity
C6Y56_RS23420	COG1845	cytochrome c oxidase, subunit III
C6Y56_RS23425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6Y56_RS23430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6Y56_RS23435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C6Y56_RS23445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y56_RS23445	COG1017	nitric oxide dioxygenase activity
C6Y56_RS23505	COG5002	protein histidine kinase activity
C6Y56_RS23520	COG2203	Gaf domain
C6Y56_RS23520	COG4251	negative regulation of phosphorylation
C6Y56_RS23520	COG5001	Diguanylate cyclase
C6Y56_RS23520	COG3706	GGDEF domain
C6Y56_RS23525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C6Y56_RS23530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6Y56_RS23545	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6Y56_RS23550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6Y56_RS23555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6Y56_RS23560	COG0772	Belongs to the SEDS family
C6Y56_RS23565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6Y56_RS23570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6Y56_RS23575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6Y56_RS23580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y56_RS23595	COG0275	rRNA processing
C6Y56_RS23600	COG2001	Belongs to the MraZ family
C6Y56_RS23620	COG0792	nuclease activity
C6Y56_RS23625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C6Y56_RS23630	COG2823	Periplasmic or secreted lipoprotein
C6Y56_RS23635	COG2969	positive regulation of protein catabolic process
C6Y56_RS23640	COG0625	glutathione transferase activity
C6Y56_RS23645	COG2857	Cytochrome c1
C6Y56_RS23650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6Y56_RS23655	COG0723	plastoquinol--plastocyanin reductase activity
C6Y56_RS23660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6Y56_RS23665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6Y56_RS23670	COG0667	Aldo Keto reductase
C6Y56_RS23675	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS23685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y56_RS23690	COG0180	Tryptophanyl-tRNA synthetase
C6Y56_RS23710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y56_RS23805	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y56_RS23810	COG2814	Major facilitator Superfamily
C6Y56_RS23820	COG1280	lysine exporter protein (LysE YggA)
C6Y56_RS23825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y56_RS23830	COG2813	Specifically methylates the guanine in position
C6Y56_RS23835	COG2119	membrane
C6Y56_RS23840	COG0501	Belongs to the peptidase M48B family
C6Y56_RS23845	COG0840	transmembrane signaling receptor activity
C6Y56_RS23850	COG3415	Transposase
C6Y56_RS23850	COG2801	Transposase and inactivated derivatives
C6Y56_RS23855	COG2135	peptidase activity
C6Y56_RS23915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6Y56_RS23925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6Y56_RS23930	COG1090	epimerase
C6Y56_RS23935	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C6Y56_RS23950	COG0789	Transcriptional regulator
C6Y56_RS23955	COG0415	Belongs to the DNA photolyase family
C6Y56_RS23965	COG4221	oxidoreductase activity
C6Y56_RS23980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6Y56_RS24000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6Y56_RS24005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6Y56_RS24015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6Y56_RS24020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6Y56_RS24030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C6Y56_RS24035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6Y56_RS24045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6Y56_RS24050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6Y56_RS24055	COG0193	aminoacyl-tRNA hydrolase activity
C6Y56_RS24065	COG2223	nitrite transmembrane transporter activity
C6Y56_RS24085	COG0405	Gamma-glutamyltransferase
C6Y56_RS24090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6Y56_RS24100	COG0477	Major facilitator Superfamily
C6Y56_RS24105	COG2031	fatty acid transporter
C6Y56_RS24125	COG0288	reversible hydration of carbon dioxide
C6Y56_RS24135	COG0456	acetyltransferase
C6Y56_RS24160	COG3008	intermembrane lipid transfer
C6Y56_RS24165	COG2995	paraquat-inducible protein a
C6Y56_RS24170	COG2995	paraquat-inducible protein a
C6Y56_RS24200	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C6Y56_RS24205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6Y56_RS24210	COG1183	phosphatidylcholine synthase activity
C6Y56_RS24215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6Y56_RS24225	COG0028	Belongs to the TPP enzyme family
C6Y56_RS24245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6Y56_RS24275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C6Y56_RS24280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6Y56_RS24285	COG4558	Periplasmic binding protein
C6Y56_RS24295	COG1489	DNA binding
C6Y56_RS24305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6Y56_RS24310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y56_RS24320	COG4191	Histidine kinase
C6Y56_RS24340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C6Y56_RS24345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C6Y56_RS24350	COG0166	Belongs to the GPI family
C6Y56_RS24355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y56_RS24360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C6Y56_RS24375	COG2823	Periplasmic or secreted lipoprotein
C6Y56_RS24395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C6Y56_RS24400	COG0237	dephospho-CoA kinase activity
C6Y56_RS24405	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C6Y56_RS24440	COG1252	NADH dehydrogenase
C6Y56_RS24475	COG0542	response to heat
C6Y56_RS24510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS24550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6Y56_RS24555	COG1047	Peptidyl-prolyl cis-trans
C6Y56_RS24560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6Y56_RS24565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6Y56_RS24570	COG0196	riboflavin kinase activity
C6Y56_RS24580	COG0268	Binds directly to 16S ribosomal RNA
C6Y56_RS24585	COG3045	CreA protein
C6Y56_RS24590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6Y56_RS24595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6Y56_RS24600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6Y56_RS24605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6Y56_RS24610	COG0142	geranyltranstransferase activity
C6Y56_RS24615	COG2824	Alkylphosphonate utilization operon protein PhnA
C6Y56_RS24620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6Y56_RS24625	COG0545	Peptidyl-prolyl cis-trans isomerase
C6Y56_RS24635	COG2862	Uncharacterized protein family, UPF0114
C6Y56_RS24650	COG1067	ATP-dependent peptidase activity
C6Y56_RS24670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y56_RS24680	COG0488	(ABC) transporter
C6Y56_RS24690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6Y56_RS24710	COG0523	cobalamin synthesis protein
C6Y56_RS24715	COG2879	small protein
C6Y56_RS24720	COG1966	Carbon starvation protein
C6Y56_RS24745	COG1970	mechanosensitive ion channel activity
C6Y56_RS24755	COG2197	response regulator
C6Y56_RS24760	COG2813	Specifically methylates the guanine in position
C6Y56_RS24770	COG1294	oxidase, subunit
C6Y56_RS24775	COG1271	oxidase subunit
C6Y56_RS24805	COG2252	PERMEase
C6Y56_RS24810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6Y56_RS24825	COG0583	DNA-binding transcription factor activity
C6Y56_RS24830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6Y56_RS24835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6Y56_RS24840	COG1309	transcriptional regulator
C6Y56_RS24850	COG0477	Major facilitator Superfamily
C6Y56_RS24880	COG0656	L-ascorbic acid biosynthetic process
C6Y56_RS24885	COG2321	neutral zinc metallopeptidase
C6Y56_RS24900	COG1946	Acyl-CoA thioesterase
C6Y56_RS24910	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6Y56_RS24920	COG0513	Belongs to the DEAD box helicase family
C6Y56_RS24925	COG0697	spore germination
C6Y56_RS24930	COG1522	sequence-specific DNA binding
C6Y56_RS24935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y56_RS24935	COG1199	ATP-dependent helicase activity
C6Y56_RS24945	COG3416	Protein conserved in bacteria
C6Y56_RS24980	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS24985	COG0583	DNA-binding transcription factor activity
C6Y56_RS24995	COG1643	Atp-dependent helicase
C6Y56_RS25005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C6Y56_RS25015	COG1522	sequence-specific DNA binding
C6Y56_RS25030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6Y56_RS25035	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS25040	COG0784	Response regulator, receiver
C6Y56_RS25040	COG2198	Histidine kinase
C6Y56_RS25040	COG2205	protein histidine kinase activity
C6Y56_RS25050	COG0352	thiamine-phosphate diphosphorylase activity
C6Y56_RS25055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6Y56_RS25070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y56_RS25075	COG1702	phosphate starvation-inducible protein PhoH
C6Y56_RS25080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6Y56_RS25085	COG4535	Mg2 and Co2 transporter CorC
C6Y56_RS25090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6Y56_RS25105	COG0495	leucyl-tRNA aminoacylation
C6Y56_RS25125	COG2951	lytic endotransglycosylase activity
C6Y56_RS25135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6Y56_RS25140	COG0321	lipoyl(octanoyl) transferase activity
C6Y56_RS25145	COG2921	Belongs to the UPF0250 family
C6Y56_RS25150	COG1686	Belongs to the peptidase S11 family
C6Y56_RS25160	COG2951	lytic endotransglycosylase activity
C6Y56_RS25165	COG0772	Belongs to the SEDS family
C6Y56_RS25170	COG0768	penicillin binding
C6Y56_RS25175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C6Y56_RS25185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6Y56_RS25190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6Y56_RS25195	COG2094	Belongs to the DNA glycosylase MPG family
C6Y56_RS25200	COG0586	Pfam SNARE associated Golgi protein
C6Y56_RS25220	COG1346	cytolysis
C6Y56_RS25240	COG0702	epimerase
C6Y56_RS25260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6Y56_RS25265	COG3284	Transcriptional regulator
C6Y56_RS25270	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS25280	COG4303	Ethanolamine ammonia lyase large subunit
C6Y56_RS25285	COG4302	ethanolamine ammonia-lyase activity
C6Y56_RS25290	COG0456	acetyltransferase
C6Y56_RS25295	COG0586	Pfam SNARE associated Golgi protein
C6Y56_RS25300	COG3228	Belongs to the MtfA family
C6Y56_RS25305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6Y56_RS25315	COG3077	Addiction module antitoxin, RelB DinJ family
C6Y56_RS25320	COG2026	Addiction module toxin, RelE StbE family
C6Y56_RS25325	COG4676	Protein conserved in bacteria
C6Y56_RS25330	COG5445	Predicted secreted protein (DUF2300)
C6Y56_RS25345	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C6Y56_RS25350	COG4676	Protein conserved in bacteria
C6Y56_RS25355	COG1722	exodeoxyribonuclease VII activity
C6Y56_RS25360	COG0142	geranyltranstransferase activity
C6Y56_RS25365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6Y56_RS25375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6Y56_RS25385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6Y56_RS25395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6Y56_RS25400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C6Y56_RS25405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6Y56_RS25410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6Y56_RS25425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6Y56_RS25425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6Y56_RS25430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6Y56_RS25440	COG2264	protein methyltransferase activity
C6Y56_RS25445	COG3118	belongs to the thioredoxin family
C6Y56_RS25475	COG3047	cAMP biosynthetic process
C6Y56_RS25480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y56_RS25490	COG1201	RNA secondary structure unwinding
C6Y56_RS25495	COG0668	transmembrane transport
C6Y56_RS25500	COG2814	Major facilitator Superfamily
C6Y56_RS25510	COG3568	Endonuclease Exonuclease Phosphatase
C6Y56_RS25515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y56_RS25520	COG0392	lysyltransferase activity
C6Y56_RS25535	COG4753	response regulator
C6Y56_RS25535	COG2207	Transcriptional regulator
C6Y56_RS25540	COG1335	isochorismatase
C6Y56_RS25545	COG3789	protein conserved in bacteria
C6Y56_RS25550	COG1842	Phage shock protein A
C6Y56_RS25560	COG3766	membrane
C6Y56_RS25570	COG0754	glutathionylspermidine amidase activity
C6Y56_RS25575	COG0629	single-stranded DNA binding
C6Y56_RS25580	COG2814	Major facilitator Superfamily
C6Y56_RS25585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6Y56_RS25590	COG2193	ferroxidase activity
C6Y56_RS25600	COG0203	ribosomal protein L17
C6Y56_RS25605	COG0202	RNA polymerase activity
C6Y56_RS25610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6Y56_RS25615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6Y56_RS25620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6Y56_RS25625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6Y56_RS25635	COG0200	Binds to the 23S rRNA
C6Y56_RS25640	COG1841	ribosomal large subunit assembly
C6Y56_RS25645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6Y56_RS25650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6Y56_RS25655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6Y56_RS25660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6Y56_RS25665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6Y56_RS25670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6Y56_RS25675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6Y56_RS25680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6Y56_RS25685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6Y56_RS25690	COG0255	Belongs to the universal ribosomal protein uL29 family
C6Y56_RS25695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6Y56_RS25700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6Y56_RS25705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6Y56_RS25710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6Y56_RS25715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6Y56_RS25720	COG0089	rRNA binding
C6Y56_RS25725	COG0088	Forms part of the polypeptide exit tunnel
C6Y56_RS25730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6Y56_RS25735	COG0051	transcription antitermination factor activity, RNA binding
C6Y56_RS25740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6Y56_RS25745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6Y56_RS25750	COG0049	tRNA binding
C6Y56_RS25755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6Y56_RS25760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6Y56_RS25765	COG0085	RNA polymerase activity
C6Y56_RS25770	COG0222	ribosome binding
C6Y56_RS25775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6Y56_RS25780	COG0081	regulation of translation
C6Y56_RS25785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6Y56_RS25805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6Y56_RS25830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C6Y56_RS25865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6Y56_RS25870	COG0739	heme binding
C6Y56_RS25875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C6Y56_RS25880	COG0316	Belongs to the HesB IscA family
C6Y56_RS25885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6Y56_RS25905	COG4221	oxidoreductase activity
C6Y56_RS25910	COG0537	adenosine 5'-monophosphoramidase activity
C6Y56_RS25915	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C6Y56_RS25920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C6Y56_RS25925	COG1765	OsmC-like protein
C6Y56_RS25940	COG0134	indole-3-glycerol-phosphate synthase activity
C6Y56_RS25945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6Y56_RS25950	COG0512	Glutamine amidotransferase of anthranilate synthase
C6Y56_RS25965	COG0546	phosphoglycolate phosphatase activity
C6Y56_RS25970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6Y56_RS25975	COG1454	alcohol dehydrogenase
C6Y56_RS25985	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y56_RS25995	COG3842	ATPase activity
C6Y56_RS26000	COG2197	response regulator
C6Y56_RS26015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6Y56_RS26020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6Y56_RS26025	COG3178	'Phosphotransferase
C6Y56_RS26030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6Y56_RS26035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y56_RS26040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C6Y56_RS26045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6Y56_RS26050	COG2967	ApaG domain
C6Y56_RS26055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6Y56_RS26060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6Y56_RS26065	COG2766	serine protein kinase
C6Y56_RS26070	COG2718	Belongs to the UPF0229 family
C6Y56_RS26075	COG2719	SpoVR family
C6Y56_RS26080	COG0617	tRNA 3'-terminal CCA addition
C6Y56_RS26090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6Y56_RS26095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C6Y56_RS26100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6Y56_RS26105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6Y56_RS26110	COG0358	DNA primase activity
C6Y56_RS26115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6Y56_RS26140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y56_RS26145	COG1025	Belongs to the peptidase M16 family
C6Y56_RS26155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6Y56_RS26160	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C6Y56_RS26170	COG0535	radical SAM domain protein
C6Y56_RS26195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6Y56_RS26200	COG0583	DNA-binding transcription factor activity
C6Y56_RS26205	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS26210	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS26215	COG3706	GGDEF domain
C6Y56_RS26220	COG1858	cytochrome C peroxidase
C6Y56_RS26225	COG1960	acyl-CoA dehydrogenase activity
C6Y56_RS26245	COG2226	methyltransferase
C6Y56_RS26245	COG1073	alpha beta
C6Y56_RS26250	COG0156	8-amino-7-oxononanoate synthase activity
C6Y56_RS26255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C6Y56_RS26265	COG2005	Transcriptional regulator
C6Y56_RS26265	COG3585	molybdate ion transport
C6Y56_RS26275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C6Y56_RS26290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6Y56_RS26295	COG2204	response regulator
C6Y56_RS26305	COG2176	DNA-directed DNA polymerase activity
C6Y56_RS26310	COG1595	DNA-templated transcription, initiation
C6Y56_RS26315	COG3712	iron ion homeostasis
C6Y56_RS26320	COG4774	siderophore transport
C6Y56_RS26335	COG0625	glutathione transferase activity
C6Y56_RS26340	COG4452	Inner membrane protein CreD
C6Y56_RS26350	COG2205	protein histidine kinase activity
C6Y56_RS26355	COG0745	RESPONSE REGULATOR receiver
C6Y56_RS26360	COG4067	protein conserved in archaea
C6Y56_RS26360	COG0189	ligase activity
C6Y56_RS26365	COG0204	Acyl-transferase
C6Y56_RS26380	COG1063	alcohol dehydrogenase
C6Y56_RS26410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6Y56_RS26435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y56_RS26435	COG1017	nitric oxide dioxygenase activity
C6Y56_RS26440	COG4638	Rieske (2fe-2S)
C6Y56_RS26450	COG1858	cytochrome C peroxidase
C6Y56_RS26465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6Y56_RS26470	COG0247	lactate metabolic process
C6Y56_RS26470	COG2181	nitrate reductase activity
C6Y56_RS26475	COG1902	pentaerythritol trinitrate reductase activity
C6Y56_RS26475	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y56_RS26525	COG3246	L-lysine catabolic process to acetate
C6Y56_RS26530	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y56_RS26555	COG1760	l-serine dehydratase
C6Y56_RS26565	COG4176	ABC-type proline glycine betaine transport system permease component
C6Y56_RS26570	COG4175	Glycine betaine
C6Y56_RS26575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6Y56_RS26580	COG1309	transcriptional regulator
C6Y56_RS26585	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS26590	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6Y56_RS26615	COG0312	modulator of DNA gyrase
C6Y56_RS26620	COG0477	Major facilitator Superfamily
C6Y56_RS26625	COG0513	Belongs to the DEAD box helicase family
C6Y56_RS26630	COG2081	HI0933 family
C6Y56_RS26635	COG1289	transmembrane transporter activity
C6Y56_RS26645	COG2153	protein acetylation
C6Y56_RS26655	COG1451	nucleotide metabolic process
C6Y56_RS26660	COG3300	MHYT domain
C6Y56_RS26660	COG5001	Diguanylate cyclase
C6Y56_RS26700	COG3550	peptidyl-serine autophosphorylation
C6Y56_RS26720	COG0126	phosphoglycerate kinase activity
C6Y56_RS26725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6Y56_RS26735	COG0640	Transcriptional regulator
C6Y56_RS26740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6Y56_RS26745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6Y56_RS26780	COG2116	formate transmembrane transporter activity
C6Y56_RS26790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6Y56_RS26795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C6Y56_RS26805	COG0513	Belongs to the DEAD box helicase family
C6Y56_RS26810	COG2353	YceI-like domain
C6Y56_RS26815	COG3038	cytochrome b561
C6Y56_RS26830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6Y56_RS26835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS26850	COG1272	protein, Hemolysin III
C6Y56_RS26890	COG3052	prosthetic group binding
C6Y56_RS26895	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C6Y56_RS26910	COG2198	Histidine kinase
C6Y56_RS26910	COG0784	Response regulator, receiver
C6Y56_RS26910	COG0643	Histidine kinase
C6Y56_RS26935	COG0189	ligase activity
C6Y56_RS26945	COG1678	Uncharacterized ACR, COG1678
C6Y56_RS26950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6Y56_RS26955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C6Y56_RS26960	COG0540	Belongs to the ATCase OTCase family
C6Y56_RS26965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6Y56_RS26975	COG0791	NLP P60 protein
C6Y56_RS27000	COG1872	DUF167
C6Y56_RS27005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y56_RS27010	COG2813	Specifically methylates the guanine in position
C6Y56_RS27010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y56_RS27020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6Y56_RS27025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6Y56_RS27035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6Y56_RS27040	COG2022	thiamine diphosphate biosynthetic process
C6Y56_RS27050	COG2363	Small membrane protein
C6Y56_RS27055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6Y56_RS27065	COG2177	Part of the ABC transporter FtsEX involved in
C6Y56_RS27070	COG2884	Cell division ATP-binding protein ftsE
C6Y56_RS27075	COG0552	protein localization to endoplasmic reticulum
C6Y56_RS27080	COG0612	Peptidase, M16
C6Y56_RS27085	COG0612	Peptidase, M16
C6Y56_RS27090	COG0742	ribosomal rna small subunit methyltransferase
C6Y56_RS27095	COG0612	Peptidase, M16
C6Y56_RS27105	COG0429	hydrolase of the alpha beta-hydrolase fold
C6Y56_RS27135	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6Y56_RS27140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6Y56_RS27145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6Y56_RS27155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6Y56_RS27180	COG2814	Major facilitator Superfamily
C6Y56_RS27185	COG0129	dihydroxy-acid dehydratase activity
C6Y56_RS27210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6Y56_RS27230	COG1840	ABC-type Fe3 transport system, periplasmic component
C6Y56_RS27235	COG1178	ABC-type Fe3 transport system permease component
C6Y56_RS27240	COG3842	ATPase activity
C6Y56_RS27245	COG0583	DNA-binding transcription factor activity
C6Y56_RS27255	COG0789	Transcriptional regulator
C6Y56_RS27260	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C6Y56_RS27265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6Y56_RS27270	COG0730	response to heat
C6Y56_RS27280	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C6Y56_RS27285	COG0494	nUDIX hydrolase
C6Y56_RS27300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y56_RS27305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6Y56_RS27310	COG3204	pilus organization
C6Y56_RS27315	COG3204	pilus organization
C6Y56_RS27320	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6Y56_RS27325	COG0277	FAD linked oxidase domain protein
C6Y56_RS27330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y56_RS27340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS27345	COG1683	Conserved Protein
C6Y56_RS27385	COG1177	transmembrane transport
C6Y56_RS27390	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y56_RS27395	COG3842	ATPase activity
C6Y56_RS27415	COG0174	glutamine synthetase
C6Y56_RS27425	COG0174	glutamine synthetase
C6Y56_RS27440	COG1116	anion transmembrane transporter activity
C6Y56_RS27445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y56_RS27450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y56_RS27455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y56_RS27460	COG0431	NADPH-dependent FMN reductase
C6Y56_RS27465	COG0450	alkyl hydroperoxide reductase
C6Y56_RS27475	COG4521	taurine ABC transporter
C6Y56_RS27480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6Y56_RS27480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C6Y56_RS27495	COG1522	sequence-specific DNA binding
C6Y56_RS27515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y56_RS27515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y56_RS27520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6Y56_RS27525	COG0509	glycine decarboxylation via glycine cleavage system
C6Y56_RS27530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6Y56_RS27535	COG1178	ABC-type Fe3 transport system permease component
C6Y56_RS27545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6Y56_RS27555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6Y56_RS27560	COG0006	proline dipeptidase activity
C6Y56_RS27565	COG3079	Belongs to the UPF0149 family
C6Y56_RS27585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6Y56_RS27600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y56_RS27605	COG1129	ABC transporter
C6Y56_RS27605	COG0842	Transport permease protein
C6Y56_RS27610	COG0842	Transport permease protein
C6Y56_RS27620	COG0604	alcohol dehydrogenase
C6Y56_RS27620	COG3321	synthase
C6Y56_RS27620	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y56_RS27625	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C6Y56_RS27635	COG2271	Major facilitator Superfamily
C6Y56_RS27655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C6Y56_RS27675	COG2186	Transcriptional regulator
C6Y56_RS27680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y56_RS27685	COG0765	amino acid transport
C6Y56_RS27695	COG1126	abc transporter atp-binding protein
C6Y56_RS27700	COG0248	Ppx GppA phosphatase
C6Y56_RS27705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6Y56_RS27715	COG0586	Pfam SNARE associated Golgi protein
C6Y56_RS27725	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C6Y56_RS27730	COG1671	Belongs to the UPF0178 family
C6Y56_RS27735	COG0672	)-iron permease
C6Y56_RS27765	COG1280	lysine exporter protein (LysE YggA)
C6Y56_RS27775	COG0488	(ABC) transporter
C6Y56_RS27800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C6Y56_RS27820	COG0181	hydroxymethylbilane synthase activity
C6Y56_RS27830	COG0165	Argininosuccinate lyase
C6Y56_RS27835	COG0625	glutathione transferase activity
C6Y56_RS27855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y56_RS27865	COG1965	Belongs to the frataxin family
C6Y56_RS27875	COG0019	diaminopimelate decarboxylase activity
C6Y56_RS27880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6Y56_RS27890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C6Y56_RS27905	COG0432	Pfam Uncharacterised protein family UPF0047
C6Y56_RS27910	COG0004	ammonium transporteR
C6Y56_RS27915	COG0347	Belongs to the P(II) protein family
C6Y56_RS27930	COG3093	addiction module antidote protein HigA
C6Y56_RS27945	COG0606	chelatase, subunit chli
C6Y56_RS27960	COG0583	DNA-binding transcription factor activity
C6Y56_RS27965	COG0534	Mate efflux family protein
C6Y56_RS27980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6Y56_RS27985	COG0427	acetyl-CoA hydrolase
C6Y56_RS28000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6Y56_RS28010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS28025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y56_RS28035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y56_RS28040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y56_RS28050	COG1012	belongs to the aldehyde dehydrogenase family
C6Y56_RS28060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6Y56_RS28065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6Y56_RS28075	COG0747	negative chemotaxis
C6Y56_RS28080	COG2003	Belongs to the UPF0758 family
C6Y56_RS28085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6Y56_RS28090	COG0756	dUTP diphosphatase activity
C6Y56_RS28095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6Y56_RS28100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6Y56_RS28105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6Y56_RS28110	COG0708	Exodeoxyribonuclease III
C6Y56_RS28120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6Y56_RS28125	COG1561	YicC-like family, N-terminal region
C6Y56_RS28130	COG0194	GDP metabolic process
C6Y56_RS28135	COG1758	RNA polymerase activity
C6Y56_RS28140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6Y56_RS28165	COG0848	biopolymer transport protein
C6Y56_RS28175	COG0583	DNA-binding transcription factor activity
C6Y56_RS28180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6Y56_RS28245	COG1090	epimerase
C6Y56_RS28295	COG3501	Rhs element vgr protein
C6Y56_RS28300	COG0515	serine threonine protein kinase
C6Y56_RS28300	COG2815	serine threonine protein kinase
C6Y56_RS28340	COG2204	response regulator
C6Y56_RS28410	COG4589	Belongs to the CDS family
C6Y56_RS28430	COG3161	chorismate lyase activity
C6Y56_RS28435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6Y56_RS28455	COG1253	flavin adenine dinucleotide binding
C6Y56_RS28460	COG0739	heme binding
C6Y56_RS28470	COG0704	Plays a role in the regulation of phosphate uptake
C6Y56_RS28475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6Y56_RS28480	COG0573	inorganic phosphate transmembrane transporter activity
C6Y56_RS28495	COG0477	Major facilitator Superfamily
C6Y56_RS28500	COG1607	acyl-coa hydrolase
C6Y56_RS28535	COG0583	DNA-binding transcription factor activity
C6Y56_RS28540	COG1027	Aspartate ammonia-lyase
C6Y56_RS28545	COG1115	amino acid carrier protein
C6Y56_RS28550	COG0252	asparaginase activity
C6Y56_RS28595	COG0456	acetyltransferase
C6Y56_RS28615	COG5016	pyruvate
C6Y56_RS28615	COG0511	ligase activity, forming carbon-carbon bonds
C6Y56_RS28620	COG0439	Biotin carboxylase
C6Y56_RS28625	COG0583	DNA-binding transcription factor activity
C6Y56_RS28645	COG0210	DNA helicase
C6Y56_RS28665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6Y56_RS28665	COG4651	solute:proton antiporter activity
C6Y56_RS28670	COG1607	acyl-coa hydrolase
C6Y56_RS28675	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C6Y56_RS28685	COG0523	cobalamin synthesis protein
C6Y56_RS28710	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6Y56_RS28715	COG1469	GTP cyclohydrolase I activity
C6Y56_RS28730	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6Y56_RS28740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6Y56_RS28750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y56_RS28755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6Y56_RS28760	COG2217	Heavy metal translocating P-type atpase
C6Y56_RS28780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y56_RS28790	COG1280	lysine exporter protein (LysE YggA)
C6Y56_RS28810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6Y56_RS28810	COG2755	lipolytic protein G-D-S-L family
C6Y56_RS28815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y56_RS28860	COG0438	transferase activity, transferring glycosyl groups
C6Y56_RS28870	COG1017	nitric oxide dioxygenase activity
C6Y56_RS28870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y56_RS28875	COG0625	glutathione transferase activity
C6Y56_RS28880	COG0583	DNA-binding transcription factor activity
C6Y56_RS28885	COG1113	amino acid transport
C6Y56_RS28890	COG2986	histidine ammonia-lyase
C6Y56_RS28895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6Y56_RS28900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6Y56_RS28905	COG1349	DNA-binding transcription factor activity
C6Y56_RS28910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6Y56_RS28915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6Y56_RS28920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6Y56_RS28925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6Y56_RS28930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6Y56_RS28935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6Y56_RS28940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6Y56_RS28950	COG0356	it plays a direct role in the translocation of protons across the membrane
C6Y56_RS28955	COG3312	ion transport
C6Y56_RS28960	COG1475	DNA binding
C6Y56_RS28965	COG1192	Involved in chromosome partitioning
C6Y56_RS28970	COG0357	Ribosomal RNA small subunit methyltransferase G
C6Y56_RS28975	COG0445	tRNA wobble uridine modification
C6Y56_RS28980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6Y56_RS28985	COG0706	membrane insertase activity
C6Y56_RS28990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6Y56_RS28995	COG0594	ribonuclease P activity
C6Y56_RS29000	COG0230	Belongs to the bacterial ribosomal protein bL34 family