locus-tag	class	description
A7318_RS00005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS00010	COG1126	abc transporter atp-binding protein
A7318_RS00015	COG0765	amino acid transport
A7318_RS00020	COG0765	amino acid transport
A7318_RS00055	COG0583	DNA-binding transcription factor activity
A7318_RS00060	COG0590	tRNA wobble adenosine to inosine editing
A7318_RS00065	COG2807	transmembrane transport
A7318_RS00090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7318_RS00100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A7318_RS00105	COG4208	sulfate ABC transporter
A7318_RS00115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7318_RS00135	COG2199	diguanylate cyclase activity
A7318_RS00140	COG0745	RESPONSE REGULATOR receiver
A7318_RS00145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7318_RS00150	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS00200	COG1595	DNA-templated transcription, initiation
A7318_RS00205	COG2304	oxidoreductase activity
A7318_RS00250	COG2831	hemolysin activation secretion protein
A7318_RS00260	COG1215	transferase activity, transferring glycosyl groups
A7318_RS00265	COG0726	polysaccharide deacetylase
A7318_RS00265	COG1649	PFAM Uncharacterised BCR, COG1649
A7318_RS00270	COG0457	Tetratricopeptide repeat
A7318_RS00275	COG5339	Protein conserved in bacteria
A7318_RS00290	COG1566	PFAM secretion protein HlyD family protein
A7318_RS00300	COG1289	transmembrane transporter activity
A7318_RS00330	COG4774	siderophore transport
A7318_RS00335	COG3712	iron ion homeostasis
A7318_RS00340	COG1595	DNA-templated transcription, initiation
A7318_RS00365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7318_RS00380	COG2175	clavaminate synthase activity
A7318_RS00385	COG1802	Transcriptional regulator
A7318_RS00410	COG0840	transmembrane signaling receptor activity
A7318_RS00415	COG1595	DNA-templated transcription, initiation
A7318_RS00420	COG3712	iron ion homeostasis
A7318_RS00440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS00460	COG2011	ABC-type metal ion transport system permease component
A7318_RS00465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7318_RS00495	COG1126	abc transporter atp-binding protein
A7318_RS00500	COG0765	amino acid transport
A7318_RS00505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS00510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A7318_RS00515	COG1045	serine acetyltransferase
A7318_RS00520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7318_RS00530	COG0667	Aldo Keto reductase
A7318_RS00535	COG2175	clavaminate synthase activity
A7318_RS00540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7318_RS00545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A7318_RS00550	COG4521	taurine ABC transporter
A7318_RS00555	COG2918	glutathione biosynthetic process
A7318_RS00565	COG2183	response to ionizing radiation
A7318_RS00580	COG0189	ligase activity
A7318_RS00585	COG4067	protein conserved in archaea
A7318_RS00585	COG0189	ligase activity
A7318_RS00590	COG3287	FIST C domain
A7318_RS00590	COG2200	EAL domain
A7318_RS00590	COG2199	diguanylate cyclase activity
A7318_RS00595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A7318_RS00605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A7318_RS00610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A7318_RS00625	COG0514	ATP-dependent DNA helicase (RecQ)
A7318_RS00630	COG0824	Thioesterase
A7318_RS00640	COG0243	molybdopterin cofactor binding
A7318_RS00645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7318_RS00655	COG1652	LysM domain
A7318_RS00660	COG1011	Hydrolase
A7318_RS00665	COG0494	nUDIX hydrolase
A7318_RS00670	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7318_RS00710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7318_RS00715	COG2957	Belongs to the agmatine deiminase family
A7318_RS00735	COG1942	4-Oxalocrotonate Tautomerase
A7318_RS00740	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS00750	COG2342	PFAM TM1410 hypothetical-related protein
A7318_RS00775	COG0438	transferase activity, transferring glycosyl groups
A7318_RS00800	COG1192	Involved in chromosome partitioning
A7318_RS00805	COG1215	transferase activity, transferring glycosyl groups
A7318_RS00810	COG1215	transferase activity, transferring glycosyl groups
A7318_RS00815	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A7318_RS00820	COG0457	Tetratricopeptide repeat
A7318_RS00845	COG2894	cell division
A7318_RS00905	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A7318_RS00910	COG1194	a g-specific adenine glycosylase
A7318_RS00920	COG2223	nitrite transmembrane transporter activity
A7318_RS00925	COG0131	Imidazoleglycerol-phosphate dehydratase
A7318_RS00930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7318_RS00940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7318_RS00945	COG0107	imidazoleglycerol-phosphate synthase activity
A7318_RS00960	COG2861	carbohydrate metabolic process
A7318_RS00965	COG0793	Belongs to the peptidase S41A family
A7318_RS00970	COG4942	peptidase
A7318_RS00975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A7318_RS00980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7318_RS00990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A7318_RS01010	COG3852	Histidine kinase
A7318_RS01025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7318_RS01025	COG0301	tRNA thio-modification
A7318_RS01030	COG1217	gtp-binding protein TYPA
A7318_RS01040	COG0058	SHG alpha-glucan phosphorylase activity
A7318_RS01055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A7318_RS01070	COG0402	S-adenosylhomocysteine deaminase activity
A7318_RS01075	COG2188	Transcriptional regulator
A7318_RS01085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A7318_RS01090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7318_RS01100	COG4176	ABC-type proline glycine betaine transport system permease component
A7318_RS01105	COG0517	IMP dehydrogenase activity
A7318_RS01105	COG4175	Glycine betaine
A7318_RS01110	COG2986	histidine ammonia-lyase
A7318_RS01115	COG2986	histidine ammonia-lyase
A7318_RS01120	COG1113	amino acid transport
A7318_RS01125	COG1228	amidohydrolase
A7318_RS01140	COG0657	acetylesterase activity
A7318_RS01145	COG0596	Alpha beta hydrolase
A7318_RS01150	COG1490	D-aminoacyl-tRNA deacylase activity
A7318_RS01155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A7318_RS01160	COG2943	transferase activity, transferring hexosyl groups
A7318_RS01165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS01175	COG0765	amino acid transport
A7318_RS01180	COG1126	abc transporter atp-binding protein
A7318_RS01185	COG0840	transmembrane signaling receptor activity
A7318_RS01190	COG0840	transmembrane signaling receptor activity
A7318_RS01215	COG0438	transferase activity, transferring glycosyl groups
A7318_RS01220	COG0859	PFAM glycosyl transferase family 9
A7318_RS01225	COG0859	PFAM glycosyl transferase family 9
A7318_RS01230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7318_RS01250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7318_RS01255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A7318_RS01260	COG2873	o-acetylhomoserine
A7318_RS01275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7318_RS01280	COG0506	proline dehydrogenase activity
A7318_RS01280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7318_RS01280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A7318_RS01290	COG1960	acyl-CoA dehydrogenase activity
A7318_RS01315	COG3263	regulation of cellular component size
A7318_RS01320	COG3264	Mechanosensitive ion channel
A7318_RS01320	COG1196	nuclear chromosome segregation
A7318_RS01325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7318_RS01330	COG5499	transcription regulator containing HTH domain
A7318_RS01335	COG4680	protein conserved in bacteria
A7318_RS01340	COG3118	belongs to the thioredoxin family
A7318_RS01345	COG1192	Involved in chromosome partitioning
A7318_RS01360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7318_RS01365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7318_RS01375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7318_RS01390	COG2986	histidine ammonia-lyase
A7318_RS01415	COG2226	methyltransferase
A7318_RS01425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7318_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS01440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7318_RS01450	COG0583	DNA-binding transcription factor activity
A7318_RS01455	COG2814	Major facilitator Superfamily
A7318_RS01460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7318_RS01465	COG0493	'glutamate synthase
A7318_RS01470	COG0070	glutamate synthase
A7318_RS01470	COG0069	glutamate synthase activity
A7318_RS01470	COG0067	glutamate synthase
A7318_RS01485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7318_RS01490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A7318_RS01520	COG0281	malic enzyme
A7318_RS01530	COG0254	rRNA binding
A7318_RS01535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7318_RS01540	COG0018	arginyl-trna synthetase
A7318_RS01550	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A7318_RS01555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A7318_RS01580	COG1309	transcriptional regulator
A7318_RS01595	COG3121	Chaperone
A7318_RS01600	COG3121	Chaperone
A7318_RS01605	COG3188	usher protein
A7318_RS01635	COG2226	methyltransferase
A7318_RS01645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7318_RS01650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7318_RS01655	COG0140	phosphoribosyl-ATP diphosphatase activity
A7318_RS01660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7318_RS01665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7318_RS01700	COG2233	PERMEase
A7318_RS01705	COG1309	transcriptional regulator
A7318_RS01710	COG1739	Uncharacterized protein family UPF0029
A7318_RS01725	COG0387	Pfam Sodium calcium exchanger
A7318_RS01730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A7318_RS01740	COG0583	DNA-binding transcription factor activity
A7318_RS01745	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A7318_RS01750	COG0604	alcohol dehydrogenase
A7318_RS01760	COG2814	Major facilitator Superfamily
A7318_RS01765	COG2217	Heavy metal translocating P-type atpase
A7318_RS01775	COG2217	Heavy metal translocating P-type atpase
A7318_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS01830	COG4964	Belongs to the GSP D family
A7318_RS01900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7318_RS01910	COG4953	penicillin-binding protein 1C
A7318_RS01920	COG2373	Large extracellular alpha-helical protein
A7318_RS01925	COG0534	Mate efflux family protein
A7318_RS01935	COG1166	arginine decarboxylase activity
A7318_RS01940	COG0023	Translation Initiation Factor
A7318_RS01965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7318_RS01980	COG2264	protein methyltransferase activity
A7318_RS01990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7318_RS02000	COG0138	bifunctional purine biosynthesis protein purh
A7318_RS02005	COG0151	Belongs to the GarS family
A7318_RS02015	COG2095	MarC family integral membrane protein
A7318_RS02040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7318_RS02095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7318_RS02120	COG0411	ABC transporter
A7318_RS02130	COG0829	nickel cation binding
A7318_RS02135	COG0831	urea catabolic process
A7318_RS02150	COG0832	Belongs to the urease beta subunit family
A7318_RS02155	COG0804	urea catabolic process
A7318_RS02160	COG0484	heat shock protein binding
A7318_RS02165	COG0443	Heat shock 70 kDa protein
A7318_RS02195	COG0697	spore germination
A7318_RS02200	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A7318_RS02210	COG2982	Protein involved in outer membrane biogenesis
A7318_RS02220	COG1309	transcriptional regulator
A7318_RS02225	COG0791	NLP P60 protein
A7318_RS02230	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A7318_RS02235	COG0830	nickel cation binding
A7318_RS02240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7318_RS02260	COG4221	oxidoreductase activity
A7318_RS02290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS02300	COG0583	DNA-binding transcription factor activity
A7318_RS02305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7318_RS02310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A7318_RS02330	COG2308	Evidence 4 Homologs of previously reported genes of
A7318_RS02330	COG2307	Protein conserved in bacteria
A7318_RS02355	COG1032	radical SAM domain protein
A7318_RS02360	COG0305	Participates in initiation and elongation during chromosome replication
A7318_RS02365	COG0359	binds to the 23S rRNA
A7318_RS02375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7318_RS02380	COG0360	Binds together with S18 to 16S ribosomal RNA
A7318_RS02385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7318_RS02390	COG0557	exoribonuclease II activity
A7318_RS02405	COG1840	ABC-type Fe3 transport system, periplasmic component
A7318_RS02410	COG1178	ABC-type Fe3 transport system permease component
A7318_RS02420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7318_RS02425	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A7318_RS02430	COG0330	HflC and HflK could
A7318_RS02435	COG0330	HflC and HflK could
A7318_RS02440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7318_RS02445	COG1923	regulation of RNA biosynthetic process
A7318_RS02450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A7318_RS02455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A7318_RS02460	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7318_RS02465	COG0802	atpase or kinase
A7318_RS02470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A7318_RS02470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A7318_RS02480	COG2860	membrane
A7318_RS02485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A7318_RS02490	COG1162	GTPase activity
A7318_RS02515	COG0688	phosphatidylethanolamine metabolic process
A7318_RS02520	COG3830	Belongs to the UPF0237 family
A7318_RS02520	COG0560	Phosphoserine phosphatase
A7318_RS02550	COG3150	esterase
A7318_RS02555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7318_RS02565	COG0494	nUDIX hydrolase
A7318_RS02580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7318_RS02585	COG1538	Outer membrane efflux protein
A7318_RS02590	COG1519	Transferase
A7318_RS02610	COG0667	Aldo Keto reductase
A7318_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7318_RS02625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7318_RS02625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7318_RS02630	COG1132	(ABC) transporter
A7318_RS02640	COG1215	transferase activity, transferring glycosyl groups
A7318_RS02645	COG0438	transferase activity, transferring glycosyl groups
A7318_RS02660	COG2192	nodulation
A7318_RS02670	COG4772	TonB-dependent receptor
A7318_RS02710	COG0280	phosphate acetyltransferase
A7318_RS02710	COG0857	belongs to the CobB CobQ family
A7318_RS02715	COG0204	Acyl-transferase
A7318_RS02725	COG0175	sulfate reduction
A7318_RS02735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7318_RS02745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7318_RS02750	COG1090	epimerase
A7318_RS02755	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A7318_RS02775	COG0415	Belongs to the DNA photolyase family
A7318_RS02785	COG4221	oxidoreductase activity
A7318_RS02790	COG0493	'glutamate synthase
A7318_RS02800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7318_RS02820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A7318_RS02825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A7318_RS02835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7318_RS02840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A7318_RS02850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A7318_RS02855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7318_RS02865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A7318_RS02870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7318_RS02875	COG0193	aminoacyl-tRNA hydrolase activity
A7318_RS02895	COG4669	(LipO)protein
A7318_RS02935	COG4792	protein secretion
A7318_RS02945	COG4794	Type iii secretion
A7318_RS02955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A7318_RS02970	COG1157	protein secretion by the type III secretion system
A7318_RS03015	COG0405	Gamma-glutamyltransferase
A7318_RS03025	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7318_RS03050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7318_RS03105	COG0477	Major facilitator Superfamily
A7318_RS03110	COG2031	fatty acid transporter
A7318_RS03130	COG0288	reversible hydration of carbon dioxide
A7318_RS03140	COG0456	acetyltransferase
A7318_RS03165	COG3008	intermembrane lipid transfer
A7318_RS03170	COG2995	paraquat-inducible protein a
A7318_RS03175	COG2995	paraquat-inducible protein a
A7318_RS03180	COG0268	Binds directly to 16S ribosomal RNA
A7318_RS03190	COG0196	riboflavin kinase activity
A7318_RS03195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7318_RS03200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7318_RS03205	COG1047	Peptidyl-prolyl cis-trans
A7318_RS03210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A7318_RS03240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS03265	COG0542	response to heat
A7318_RS03290	COG1252	NADH dehydrogenase
A7318_RS03320	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A7318_RS03325	COG0237	dephospho-CoA kinase activity
A7318_RS03370	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7318_RS03390	COG0084	hydrolase, TatD family'
A7318_RS03395	COG1609	Transcriptional regulator
A7318_RS03405	COG1105	Belongs to the carbohydrate kinase PfkB family
A7318_RS03410	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7318_RS03410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7318_RS03410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7318_RS03420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7318_RS03425	COG4774	siderophore transport
A7318_RS03430	COG3128	pkhd-type hydroxylase
A7318_RS03440	COG0019	diaminopimelate decarboxylase activity
A7318_RS03465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7318_RS03480	COG4608	Belongs to the ABC transporter superfamily
A7318_RS03485	COG0444	Belongs to the ABC transporter superfamily
A7318_RS03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7318_RS03495	COG0601	transmembrane transport
A7318_RS03500	COG0747	negative chemotaxis
A7318_RS03510	COG0747	negative chemotaxis
A7318_RS03515	COG0747	negative chemotaxis
A7318_RS03520	COG0747	negative chemotaxis
A7318_RS03540	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A7318_RS03560	COG0180	Tryptophanyl-tRNA synthetase
A7318_RS03565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7318_RS03575	COG1960	acyl-CoA dehydrogenase activity
A7318_RS03580	COG0667	Aldo Keto reductase
A7318_RS03585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7318_RS03590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7318_RS03595	COG0723	plastoquinol--plastocyanin reductase activity
A7318_RS03600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A7318_RS03605	COG2857	Cytochrome c1
A7318_RS03610	COG0625	glutathione transferase activity
A7318_RS03615	COG2969	positive regulation of protein catabolic process
A7318_RS03620	COG2186	Transcriptional regulator
A7318_RS03635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7318_RS03645	COG2271	Major facilitator Superfamily
A7318_RS03650	COG2721	sulfolactate sulfo-lyase activity
A7318_RS03660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7318_RS03670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7318_RS03675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7318_RS03680	COG0154	amidase activity
A7318_RS03685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7318_RS03690	COG1077	Cell shape determining protein MreB Mrl
A7318_RS03695	COG1792	Involved in formation and maintenance of cell shape
A7318_RS03705	COG0424	maF-like protein
A7318_RS03710	COG1530	ribonuclease E activity
A7318_RS03720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7318_RS03725	COG0312	modulator of DNA gyrase
A7318_RS03730	COG3028	Belongs to the UPF0307 family
A7318_RS03735	COG0312	modulator of DNA gyrase
A7318_RS03770	COG1660	Displays ATPase and GTPase activities
A7318_RS03780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7318_RS03785	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7318_RS03790	COG1137	ATPase activity
A7318_RS03795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A7318_RS03805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A7318_RS03815	COG1127	ABC transporter
A7318_RS03820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7318_RS03825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7318_RS03845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7318_RS03850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7318_RS03855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A7318_RS03860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7318_RS03870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7318_RS03875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7318_RS03935	COG2135	peptidase activity
A7318_RS03940	COG0840	transmembrane signaling receptor activity
A7318_RS03945	COG0501	Belongs to the peptidase M48B family
A7318_RS03950	COG2119	membrane
A7318_RS03955	COG2813	Specifically methylates the guanine in position
A7318_RS03960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7318_RS03965	COG1280	lysine exporter protein (LysE YggA)
A7318_RS03970	COG0318	PFAM AMP-dependent synthetase and ligase
A7318_RS03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7318_RS04000	COG2885	chlorophyll binding
A7318_RS04005	COG2823	Periplasmic or secreted lipoprotein
A7318_RS04010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A7318_RS04035	COG2001	Belongs to the MraZ family
A7318_RS04040	COG0275	rRNA processing
A7318_RS04055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7318_RS04060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7318_RS04065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7318_RS04070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7318_RS04075	COG0772	Belongs to the SEDS family
A7318_RS04080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7318_RS04085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7318_RS04090	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7318_RS04105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A7318_RS04110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A7318_RS04115	COG2203	Gaf domain
A7318_RS04115	COG3706	GGDEF domain
A7318_RS04115	COG4251	negative regulation of phosphorylation
A7318_RS04115	COG5001	Diguanylate cyclase
A7318_RS04125	COG5002	protein histidine kinase activity
A7318_RS04150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS04165	COG0835	chemotaxis
A7318_RS04165	COG0784	Response regulator, receiver
A7318_RS04175	COG0583	DNA-binding transcription factor activity
A7318_RS04200	COG1566	PFAM secretion protein HlyD family protein
A7318_RS04220	COG0300	oxidoreductase activity
A7318_RS04235	COG0662	Cupin 2, conserved barrel domain protein
A7318_RS04235	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A7318_RS04250	COG1696	Membrane protein involved in D-alanine export
A7318_RS04265	COG3420	alginic acid biosynthetic process
A7318_RS04275	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A7318_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS04285	COG1215	transferase activity, transferring glycosyl groups
A7318_RS04295	COG3022	response to hydroperoxide
A7318_RS04305	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7318_RS04310	COG0315	cyclic pyranopterin monophosphate synthase activity
A7318_RS04315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A7318_RS04325	COG0513	Belongs to the DEAD box helicase family
A7318_RS04330	COG0400	carboxylic ester hydrolase activity
A7318_RS04335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS04340	COG4597	amino acid ABC transporter
A7318_RS04345	COG0765	amino acid transport
A7318_RS04350	COG1126	abc transporter atp-binding protein
A7318_RS04360	COG2186	Transcriptional regulator
A7318_RS04365	COG2807	transmembrane transport
A7318_RS04370	COG3539	Fimbrial protein
A7318_RS04375	COG3539	Fimbrial protein
A7318_RS04380	COG3188	usher protein
A7318_RS04385	COG3121	Chaperone
A7318_RS04430	COG2827	Endonuclease containing a URI domain
A7318_RS04440	COG4774	siderophore transport
A7318_RS04445	COG2027	D-alanyl-D-alanine carboxypeptidase
A7318_RS04455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A7318_RS04460	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7318_RS04480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A7318_RS04500	COG0814	amino acid
A7318_RS04505	COG1760	l-serine dehydratase
A7318_RS04510	COG0583	DNA-binding transcription factor activity
A7318_RS04520	COG0477	Major facilitator Superfamily
A7318_RS04525	COG0583	DNA-binding transcription factor activity
A7318_RS04530	COG4772	TonB-dependent receptor
A7318_RS04535	COG3712	iron ion homeostasis
A7318_RS04540	COG1595	DNA-templated transcription, initiation
A7318_RS04565	COG3712	iron ion homeostasis
A7318_RS04575	COG3081	Nucleoid-associated protein
A7318_RS04585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A7318_RS04590	COG0525	valine-tRNA ligase activity
A7318_RS04605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A7318_RS04610	COG0795	lipopolysaccharide-transporting ATPase activity
A7318_RS04615	COG0795	lipopolysaccharide-transporting ATPase activity
A7318_RS04620	COG0481	GTPase activity
A7318_RS04625	COG0681	Belongs to the peptidase S26 family
A7318_RS04630	COG0571	ribonuclease III activity
A7318_RS04635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A7318_RS04640	COG1381	Involved in DNA repair and RecF pathway recombination
A7318_RS04645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A7318_RS04655	COG0590	tRNA wobble adenosine to inosine editing
A7318_RS04660	COG0500	methyltransferase
A7318_RS04665	COG2226	methyltransferase
A7318_RS04680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7318_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS04720	COG0523	cobalamin synthesis protein
A7318_RS04745	COG4206	TonB-dependent receptor
A7318_RS04750	COG4628	conserved protein (DUF2132)
A7318_RS04760	COG2375	cellular response to nickel ion
A7318_RS04765	COG1695	Transcriptional regulator
A7318_RS04805	COG1113	amino acid transport
A7318_RS04825	COG0069	glutamate synthase activity
A7318_RS04830	COG2197	response regulator
A7318_RS04840	COG0531	amino acid
A7318_RS04845	COG0254	rRNA binding
A7318_RS04865	COG0583	DNA-binding transcription factor activity
A7318_RS04870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7318_RS04890	COG2076	Multidrug Resistance protein
A7318_RS04910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7318_RS04925	COG4191	Histidine kinase
A7318_RS04930	COG2204	response regulator
A7318_RS04950	COG1126	abc transporter atp-binding protein
A7318_RS04955	COG0765	amino acid transport
A7318_RS04960	COG0765	amino acid transport
A7318_RS04965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS04980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7318_RS04990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7318_RS04995	COG3842	ATPase activity
A7318_RS05000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7318_RS05005	COG0243	molybdopterin cofactor binding
A7318_RS05010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A7318_RS05025	COG0450	alkyl hydroperoxide reductase
A7318_RS05030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7318_RS05035	COG0418	dihydroorotase activity
A7318_RS05045	COG0137	argininosuccinate synthase activity
A7318_RS05050	COG2197	response regulator
A7318_RS05060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7318_RS05065	COG2878	Part of a membrane complex involved in electron transport
A7318_RS05070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7318_RS05070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7318_RS05075	COG0489	protein tyrosine kinase activity
A7318_RS05080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A7318_RS05085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A7318_RS05170	COG3179	chitinase
A7318_RS05180	COG1546	Belongs to the CinA family
A7318_RS05185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7318_RS05190	COG2137	regulation of response to DNA damage stimulus
A7318_RS05205	COG3148	PFAM DTW domain containing protein
A7318_RS05220	COG0583	DNA-binding transcription factor activity
A7318_RS05235	COG4807	Protein conserved in bacteria
A7318_RS05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7318_RS05255	COG3158	transport of potassium into the cell
A7318_RS05260	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS05270	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A7318_RS05275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A7318_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS05285	COG1177	transmembrane transport
A7318_RS05290	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7318_RS05295	COG3842	ATPase activity
A7318_RS05300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A7318_RS05310	COG0583	DNA-binding transcription factor activity
A7318_RS05330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7318_RS05330	COG0457	Tetratricopeptide repeat
A7318_RS05335	COG0835	chemotaxis
A7318_RS05345	COG2201	protein-glutamate methylesterase activity
A7318_RS05350	COG3706	GGDEF domain
A7318_RS05350	COG2203	Gaf domain
A7318_RS05350	COG4251	negative regulation of phosphorylation
A7318_RS05350	COG5001	Diguanylate cyclase
A7318_RS05360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A7318_RS05365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7318_RS05385	COG1073	alpha beta
A7318_RS05400	COG2885	chlorophyll binding
A7318_RS05425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7318_RS05430	COG0563	adenylate kinase activity
A7318_RS05435	COG1214	PFAM Peptidase M22, glycoprotease
A7318_RS05445	COG1801	Protein of unknown function DUF72
A7318_RS05465	COG0742	ribosomal rna small subunit methyltransferase
A7318_RS05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS05495	COG2937	Belongs to the GPAT DAPAT family
A7318_RS05510	COG2226	methyltransferase
A7318_RS05515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7318_RS05525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A7318_RS05530	COG2166	iron-sulfur cluster assembly
A7318_RS05535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7318_RS05540	COG2171	N-acyltransferase activity
A7318_RS05545	COG1393	Belongs to the ArsC family
A7318_RS05550	COG0025	NhaP-type Na H and K H
A7318_RS05565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7318_RS05575	COG0052	Belongs to the universal ribosomal protein uS2 family
A7318_RS05580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7318_RS05585	COG0528	UMP kinase activity
A7318_RS05590	COG0233	cytoplasmic translational termination
A7318_RS05595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7318_RS05605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7318_RS05625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7318_RS05630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7318_RS05635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7318_RS05640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7318_RS05645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A7318_RS05650	COG0587	DNA-directed DNA polymerase activity
A7318_RS05655	COG0825	malonyl-CoA metabolic process
A7318_RS05660	COG0037	tRNA processing
A7318_RS05665	COG0504	CTP synthase activity
A7318_RS05670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A7318_RS05675	COG0148	phosphopyruvate hydratase activity
A7318_RS05685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7318_RS05695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A7318_RS05700	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A7318_RS05705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7318_RS05710	COG0585	pseudouridine synthase activity
A7318_RS05715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A7318_RS05720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A7318_RS05730	COG1278	Cold shock
A7318_RS05735	COG0717	Belongs to the dCTP deaminase family
A7318_RS05750	COG1201	RNA secondary structure unwinding
A7318_RS05780	COG1793	dna ligase
A7318_RS05790	COG2366	antibiotic biosynthetic process
A7318_RS05795	COG0625	glutathione transferase activity
A7318_RS05800	COG0653	protein targeting
A7318_RS05810	COG3012	SEC-C Motif Domain Protein
A7318_RS05835	COG1199	ATP-dependent helicase activity
A7318_RS05845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7318_RS05855	COG0259	pyridoxamine-phosphate oxidase activity
A7318_RS05870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7318_RS05880	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A7318_RS05895	COG0583	DNA-binding transcription factor activity
A7318_RS05910	COG3220	belongs to the UPF0276 family
A7318_RS05965	COG2271	Major facilitator Superfamily
A7318_RS05970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7318_RS05980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7318_RS05990	COG0583	DNA-binding transcription factor activity
A7318_RS05995	COG0306	phosphate transporter
A7318_RS06005	COG1414	Transcriptional regulator
A7318_RS06010	COG2814	Major facilitator Superfamily
A7318_RS06015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A7318_RS06020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A7318_RS06025	COG0183	Belongs to the thiolase family
A7318_RS06030	COG3485	protocatechuate 3,4-dioxygenase
A7318_RS06035	COG3485	protocatechuate 3,4-dioxygenase
A7318_RS06040	COG0477	Major facilitator Superfamily
A7318_RS06050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7318_RS06055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7318_RS06080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS06085	COG1309	transcriptional regulator
A7318_RS06090	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS06095	COG2814	Major facilitator Superfamily
A7318_RS06130	COG1473	amidohydrolase
A7318_RS06140	COG0154	amidase activity
A7318_RS06155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7318_RS06165	COG1704	LemA family
A7318_RS06190	COG1629	transport
A7318_RS06200	COG1595	DNA-templated transcription, initiation
A7318_RS06205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7318_RS06210	COG0235	Class ii aldolase
A7318_RS06215	COG1396	sequence-specific DNA binding
A7318_RS06225	COG1454	alcohol dehydrogenase
A7318_RS06245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7318_RS06250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7318_RS06255	COG2271	Major facilitator Superfamily
A7318_RS06295	COG0583	DNA-binding transcription factor activity
A7318_RS06300	COG2814	Major facilitator Superfamily
A7318_RS06325	COG2267	carboxylic ester hydrolase activity
A7318_RS06355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A7318_RS06405	COG0642	Histidine kinase
A7318_RS06420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A7318_RS06450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7318_RS06460	COG0425	Belongs to the sulfur carrier protein TusA family
A7318_RS06470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A7318_RS06480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7318_RS06485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A7318_RS06490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7318_RS06495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7318_RS06515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS06515	COG2205	protein histidine kinase activity
A7318_RS06520	COG2197	response regulator
A7318_RS06540	COG1595	DNA-templated transcription, initiation
A7318_RS06550	COG0583	DNA-binding transcription factor activity
A7318_RS06555	COG0477	Major facilitator Superfamily
A7318_RS06570	COG0784	Response regulator, receiver
A7318_RS06570	COG4191	Histidine kinase
A7318_RS06585	COG2172	sigma factor antagonist activity
A7318_RS06590	COG1366	Belongs to the anti-sigma-factor antagonist family
A7318_RS06595	COG1366	Belongs to the anti-sigma-factor antagonist family
A7318_RS06600	COG0583	DNA-binding transcription factor activity
A7318_RS06620	COG1802	Transcriptional regulator
A7318_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS06630	COG3246	L-lysine catabolic process to acetate
A7318_RS06665	COG2807	transmembrane transport
A7318_RS06670	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS06680	COG0583	DNA-binding transcription factor activity
A7318_RS06685	COG2910	NAD(P)H-binding
A7318_RS06695	COG0583	DNA-binding transcription factor activity
A7318_RS06725	COG0174	glutamine synthetase
A7318_RS06740	COG3100	YcgL domain-containing protein
A7318_RS06745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7318_RS06755	COG2983	Belongs to the UPF0260 family
A7318_RS06800	COG1770	oligopeptidase
A7318_RS06810	COG0121	glutamine amidotransferase
A7318_RS06820	COG0583	DNA-binding transcription factor activity
A7318_RS06825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7318_RS06830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A7318_RS06835	COG1984	allophanate hydrolase subunit 2
A7318_RS06850	COG0542	response to heat
A7318_RS06860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7318_RS06875	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A7318_RS06880	COG0425	Belongs to the sulfur carrier protein TusA family
A7318_RS06890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7318_RS06895	COG1132	(ABC) transporter
A7318_RS06900	COG0741	lytic transglycosylase activity
A7318_RS06905	COG0488	(ABC) transporter
A7318_RS06910	COG0589	response to stress
A7318_RS06920	COG1024	Enoyl-CoA hydratase
A7318_RS06920	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7318_RS06925	COG0183	Belongs to the thiolase family
A7318_RS06970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7318_RS06980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7318_RS06995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7318_RS07000	COG0584	glycerophosphoryl diester phosphodiesterase
A7318_RS07010	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7318_RS07015	COG1136	(ABC) transporter
A7318_RS07020	COG4591	ABC-type transport system involved in lipoprotein release permease component
A7318_RS07040	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7318_RS07040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A7318_RS07055	COG2853	Lipoprotein
A7318_RS07065	COG2204	response regulator
A7318_RS07075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7318_RS07080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7318_RS07090	COG2814	Major facilitator Superfamily
A7318_RS07095	COG0579	oxidoreductase
A7318_RS07105	COG0583	DNA-binding transcription factor activity
A7318_RS07125	COG0251	oxidation-reduction process
A7318_RS07130	COG1611	Belongs to the LOG family
A7318_RS07140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7318_RS07150	COG0583	DNA-binding transcription factor activity
A7318_RS07155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7318_RS07160	COG0583	DNA-binding transcription factor activity
A7318_RS07165	COG2814	Major facilitator Superfamily
A7318_RS07175	COG2233	PERMEase
A7318_RS07180	COG2267	carboxylic ester hydrolase activity
A7318_RS07185	COG2197	response regulator
A7318_RS07190	COG0596	Alpha beta hydrolase
A7318_RS07200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7318_RS07205	COG0444	Belongs to the ABC transporter superfamily
A7318_RS07210	COG4608	Belongs to the ABC transporter superfamily
A7318_RS07215	COG0747	negative chemotaxis
A7318_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS07225	COG0546	phosphoglycolate phosphatase activity
A7318_RS07230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7318_RS07235	COG0402	S-adenosylhomocysteine deaminase activity
A7318_RS07240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A7318_RS07250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A7318_RS07260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7318_RS07265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7318_RS07270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A7318_RS07285	COG0776	regulation of translation
A7318_RS07330	COG2244	polysaccharide biosynthetic process
A7318_RS07335	COG1216	Glycosyl transferase, family 2
A7318_RS07365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7318_RS07375	COG1555	photosystem II stabilization
A7318_RS07405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A7318_RS07415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A7318_RS07420	COG2205	protein histidine kinase activity
A7318_RS07425	COG0745	RESPONSE REGULATOR receiver
A7318_RS07470	COG0084	hydrolase, TatD family'
A7318_RS07475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7318_RS07480	COG2259	Doxx family
A7318_RS07500	COG1131	(ABC) transporter
A7318_RS07510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7318_RS07515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A7318_RS07520	COG4181	ATPase activity
A7318_RS07535	COG1376	ErfK ybiS ycfS ynhG family protein
A7318_RS07565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A7318_RS07585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7318_RS07600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7318_RS07610	COG1764	response to oxidative stress
A7318_RS07615	COG1846	Transcriptional regulator
A7318_RS07620	COG0583	DNA-binding transcription factor activity
A7318_RS07625	COG0730	response to heat
A7318_RS07630	COG0583	DNA-binding transcription factor activity
A7318_RS07640	COG3214	Protein conserved in bacteria
A7318_RS07645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A7318_RS07670	COG3384	dioxygenase
A7318_RS07675	COG0500	methyltransferase
A7318_RS07680	COG0501	Belongs to the peptidase M48B family
A7318_RS07685	COG0436	Aminotransferase
A7318_RS07690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7318_RS07695	COG0386	Belongs to the glutathione peroxidase family
A7318_RS07700	COG1846	Transcriptional regulator
A7318_RS07715	COG1956	GAF domain-containing protein
A7318_RS07720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS07720	COG2205	protein histidine kinase activity
A7318_RS07725	COG2197	response regulator
A7318_RS07730	COG2204	response regulator
A7318_RS07740	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A7318_RS07760	COG0004	ammonium transporteR
A7318_RS07780	COG0564	pseudouridine synthase activity
A7318_RS07790	COG0746	molybdenum cofactor guanylyltransferase activity
A7318_RS07795	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7318_RS07800	COG0303	'Molybdopterin
A7318_RS07805	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7318_RS07815	COG4133	protoheme IX ABC transporter activity
A7318_RS07835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A7318_RS07840	COG1138	Cytochrome C-type biogenesis protein
A7318_RS07850	COG3088	subunit of a heme lyase
A7318_RS07855	COG4235	cytochrome complex assembly
A7318_RS07865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A7318_RS07870	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A7318_RS07875	COG3639	organic phosphonate transmembrane transporter activity
A7318_RS07880	COG2188	Transcriptional regulator
A7318_RS07885	COG3624	Phosphonate C-P lyase system protein PhnG
A7318_RS07895	COG3626	phosphonate metabolism
A7318_RS07900	COG3627	carbon phosphorus lyase activity
A7318_RS07905	COG4107	phosphonate C-P lyase system protein PhnK
A7318_RS07910	COG4778	phosphonate C-P lyase system protein PhnL
A7318_RS07915	COG3454	Phosphonate metabolism
A7318_RS07920	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A7318_RS07925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7318_RS07930	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A7318_RS07950	COG2814	Major facilitator Superfamily
A7318_RS07965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7318_RS07975	COG0469	pyruvate kinase activity
A7318_RS07985	COG2084	Dehydrogenase
A7318_RS07990	COG3622	Belongs to the hyi family
A7318_RS07995	COG3960	tartronate-semialdehyde synthase activity
A7318_RS08010	COG1309	transcriptional regulator
A7318_RS08015	COG2354	Protein conserved in bacteria
A7318_RS08020	COG2853	Lipoprotein
A7318_RS08040	COG2113	Glycine betaine
A7318_RS08045	COG3162	membrane
A7318_RS08050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7318_RS08060	COG2009	succinate dehydrogenase
A7318_RS08065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A7318_RS08070	COG1053	succinate dehydrogenase
A7318_RS08075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7318_RS08090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7318_RS08095	COG0045	succinate-CoA ligase (ADP-forming) activity
A7318_RS08130	COG0326	Molecular chaperone. Has ATPase activity
A7318_RS08140	COG1741	Belongs to the pirin family
A7318_RS08155	COG0840	transmembrane signaling receptor activity
A7318_RS08165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A7318_RS08170	COG0784	Response regulator, receiver
A7318_RS08170	COG2205	protein histidine kinase activity
A7318_RS08170	COG5002	protein histidine kinase activity
A7318_RS08180	COG4771	TonB-dependent receptor
A7318_RS08185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A7318_RS08200	COG1022	Amp-dependent synthetase and ligase
A7318_RS08225	COG0628	permease
A7318_RS08240	COG0284	orotidine-5'-phosphate decarboxylase activity
A7318_RS08245	COG2130	NADP-dependent
A7318_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS08255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS08260	COG0840	transmembrane signaling receptor activity
A7318_RS08265	COG2267	carboxylic ester hydrolase activity
A7318_RS08280	COG0842	Transport permease protein
A7318_RS08285	COG1131	(ABC) transporter
A7318_RS08290	COG0625	glutathione transferase activity
A7318_RS08300	COG1960	acyl-CoA dehydrogenase activity
A7318_RS08315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7318_RS08320	COG3540	Alkaline phosphatase
A7318_RS08345	COG0811	peptide transport
A7318_RS08360	COG2871	sodium ion transport
A7318_RS08375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A7318_RS08380	COG2197	response regulator
A7318_RS08430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7318_RS08490	COG0477	Major facilitator Superfamily
A7318_RS08495	COG2076	Multidrug Resistance protein
A7318_RS08500	COG0385	Bile acid
A7318_RS08505	COG2974	May be involved in recombination
A7318_RS08530	COG3712	iron ion homeostasis
A7318_RS08535	COG1595	DNA-templated transcription, initiation
A7318_RS08565	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7318_RS08575	COG3842	ATPase activity
A7318_RS08595	COG2200	EAL domain
A7318_RS08615	COG0545	Peptidyl-prolyl cis-trans isomerase
A7318_RS08620	COG2010	Cytochrome c
A7318_RS08640	COG5006	permease, DMT superfamily
A7318_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS08665	COG0583	DNA-binding transcription factor activity
A7318_RS08690	COG0431	NADPH-dependent FMN reductase
A7318_RS08695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS08705	COG3829	transcription factor binding
A7318_RS08720	COG0596	Alpha beta hydrolase
A7318_RS08725	COG1301	dicarboxylic acid transport
A7318_RS08730	COG0583	DNA-binding transcription factor activity
A7318_RS08735	COG0066	3-isopropylmalate dehydratase activity
A7318_RS08740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7318_RS08770	COG1121	(ABC) transporter
A7318_RS08775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7318_RS08785	COG0768	penicillin binding
A7318_RS08805	COG0417	DNA replication proofreading
A7318_RS08830	COG0728	peptidoglycan biosynthetic process
A7318_RS08855	COG0297	glycogen (starch) synthase activity
A7318_RS08875	COG0662	Cupin 2, conserved barrel domain protein
A7318_RS08875	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A7318_RS08880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A7318_RS08905	COG4977	sequence-specific DNA binding
A7318_RS08910	COG0596	Alpha beta hydrolase
A7318_RS08920	COG3387	PFAM Glycoside hydrolase 15-related
A7318_RS08925	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS08930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7318_RS08935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7318_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS08965	COG0529	Catalyzes the synthesis of activated sulfate
A7318_RS08975	COG1595	DNA-templated transcription, initiation
A7318_RS08985	COG4772	TonB-dependent receptor
A7318_RS09000	COG2223	nitrite transmembrane transporter activity
A7318_RS09005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7318_RS09020	COG3675	Pfam Lipase (class 3)
A7318_RS09025	COG0402	S-adenosylhomocysteine deaminase activity
A7318_RS09035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7318_RS09040	COG1051	belongs to the nudix hydrolase family
A7318_RS09050	COG0720	synthase
A7318_RS09215	COG0784	Response regulator, receiver
A7318_RS09215	COG4191	Histidine kinase
A7318_RS09235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7318_RS09405	COG3179	chitinase
A7318_RS09425	COG0582	viral genome integration into host DNA
A7318_RS09455	COG0840	transmembrane signaling receptor activity
A7318_RS09460	COG2056	Na+-H+ antiporter family
A7318_RS09470	COG0826	peptidase U32
A7318_RS09485	COG0628	permease
A7318_RS09500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7318_RS09505	COG3132	Protein of unknown function, DUF480
A7318_RS09515	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A7318_RS09525	COG0583	DNA-binding transcription factor activity
A7318_RS09535	COG1253	flavin adenine dinucleotide binding
A7318_RS09540	COG0709	Synthesizes selenophosphate from selenide and ATP
A7318_RS09545	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A7318_RS09550	COG0701	Predicted permease
A7318_RS09560	COG0625	glutathione transferase activity
A7318_RS09565	COG0384	phenazine biosynthesis protein PhzF
A7318_RS09570	COG0113	porphobilinogen synthase activity
A7318_RS09605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A7318_RS09610	COG0583	DNA-binding transcription factor activity
A7318_RS09620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7318_RS09625	COG0517	IMP dehydrogenase activity
A7318_RS09630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7318_RS09655	COG4335	DNA alkylation repair
A7318_RS09660	COG0174	glutamine synthetase
A7318_RS09680	COG2814	Major facilitator Superfamily
A7318_RS09690	COG3237	CsbD-like
A7318_RS09715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7318_RS09740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7318_RS09750	COG2197	response regulator
A7318_RS09755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS09755	COG2205	protein histidine kinase activity
A7318_RS09765	COG0656	L-ascorbic acid biosynthetic process
A7318_RS09770	COG1309	transcriptional regulator
A7318_RS09775	COG1024	Enoyl-CoA hydratase
A7318_RS09780	COG1960	acyl-CoA dehydrogenase activity
A7318_RS09795	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7318_RS09800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7318_RS09825	COG2197	response regulator
A7318_RS09830	COG0322	excinuclease ABC activity
A7318_RS09855	COG2202	Pas domain
A7318_RS09855	COG2199	diguanylate cyclase activity
A7318_RS09855	COG2200	EAL domain
A7318_RS09860	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A7318_RS09865	COG2197	response regulator
A7318_RS09880	COG0784	Response regulator, receiver
A7318_RS09880	COG4191	Histidine kinase
A7318_RS09895	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7318_RS09895	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS09900	COG2113	Glycine betaine
A7318_RS09920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7318_RS09925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS09955	COG4214	carbohydrate transport
A7318_RS09960	COG1129	ABC transporter
A7318_RS09965	COG4213	ABC transporter substrate-binding protein
A7318_RS09970	COG2115	Belongs to the xylose isomerase family
A7318_RS09975	COG2207	Transcriptional regulator
A7318_RS09975	COG1609	Transcriptional regulator
A7318_RS09995	COG3781	membrane
A7318_RS10005	COG2199	diguanylate cyclase activity
A7318_RS10015	COG0640	Transcriptional regulator
A7318_RS10020	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS10025	COG2135	peptidase activity
A7318_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS10065	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS10070	COG1129	ABC transporter
A7318_RS10075	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS10105	COG0625	glutathione transferase activity
A7318_RS10110	COG1968	undecaprenyl-diphosphatase activity
A7318_RS10125	COG1309	transcriptional regulator
A7318_RS10135	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS10140	COG0604	alcohol dehydrogenase
A7318_RS10140	COG3321	synthase
A7318_RS10145	COG0583	DNA-binding transcription factor activity
A7318_RS10160	COG1064	alcohol dehydrogenase
A7318_RS10165	COG1971	Probably functions as a manganese efflux pump
A7318_RS10175	COG0583	DNA-binding transcription factor activity
A7318_RS10205	COG0475	glutathione-regulated potassium exporter activity
A7318_RS10205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7318_RS10215	COG0697	spore germination
A7318_RS10220	COG0367	asparagine synthase
A7318_RS10230	COG1024	Enoyl-CoA hydratase
A7318_RS10235	COG2207	Transcriptional regulator
A7318_RS10320	COG2204	response regulator
A7318_RS10325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A7318_RS10330	COG3046	protein related to deoxyribodipyrimidine photolyase
A7318_RS10335	COG1366	Belongs to the anti-sigma-factor antagonist family
A7318_RS10350	COG0302	gtp cyclohydrolase
A7318_RS10360	COG2351	hydroxyisourate hydrolase activity
A7318_RS10385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS10400	COG1177	transmembrane transport
A7318_RS10405	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7318_RS10410	COG3842	ATPase activity
A7318_RS10415	COG1414	Transcriptional regulator
A7318_RS10425	COG2198	Histidine kinase
A7318_RS10425	COG0784	Response regulator, receiver
A7318_RS10425	COG2205	protein histidine kinase activity
A7318_RS10425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS10445	COG3842	ATPase activity
A7318_RS10460	COG0114	fumarate hydratase activity
A7318_RS10465	COG1301	dicarboxylic acid transport
A7318_RS10475	COG2188	Transcriptional regulator
A7318_RS10480	COG0840	transmembrane signaling receptor activity
A7318_RS10495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7318_RS10505	COG0534	Mate efflux family protein
A7318_RS10510	COG1309	transcriptional regulator
A7318_RS10595	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7318_RS10595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7318_RS10600	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7318_RS10600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7318_RS10605	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7318_RS10605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7318_RS10615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7318_RS10645	COG2816	NAD+ diphosphatase activity
A7318_RS10650	COG1024	Enoyl-CoA hydratase
A7318_RS10655	COG0038	chloride channel
A7318_RS10660	COG3012	SEC-C Motif Domain Protein
A7318_RS10660	COG3318	Belongs to the UPF0149 family
A7318_RS10665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A7318_RS10705	COG0784	Response regulator, receiver
A7318_RS10705	COG4191	Histidine kinase
A7318_RS10715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7318_RS10730	COG1285	pathogenesis
A7318_RS10740	COG0348	domain, Protein
A7318_RS10745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS10760	COG1538	Outer membrane efflux protein
A7318_RS10770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7318_RS10800	COG1175	transmembrane transport
A7318_RS10820	COG1070	Carbohydrate kinase
A7318_RS10845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7318_RS10855	COG0024	Methionine aminopeptidase
A7318_RS10860	COG0598	Magnesium transport protein CorA
A7318_RS10865	COG0189	ligase activity
A7318_RS10875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS10885	COG0730	response to heat
A7318_RS10910	COG2205	protein histidine kinase activity
A7318_RS10915	COG0745	RESPONSE REGULATOR receiver
A7318_RS10920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS10925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7318_RS10945	COG1609	Transcriptional regulator
A7318_RS10955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7318_RS10975	COG2233	PERMEase
A7318_RS11065	COG0561	phosphatase activity
A7318_RS11070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7318_RS11075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A7318_RS11080	COG2194	sulfuric ester hydrolase activity
A7318_RS11100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7318_RS11115	COG0667	Aldo Keto reductase
A7318_RS11120	COG0308	aminopeptidase N
A7318_RS11130	COG3139	Protein of unknown function (DUF1315)
A7318_RS11140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7318_RS11145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A7318_RS11195	COG0316	Belongs to the HesB IscA family
A7318_RS11195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A7318_RS11220	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS11225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7318_RS11235	COG0789	Transcriptional regulator
A7318_RS11245	COG0028	Belongs to the TPP enzyme family
A7318_RS11250	COG0431	NADPH-dependent FMN reductase
A7318_RS11280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7318_RS11285	COG0328	RNA-DNA hybrid ribonuclease activity
A7318_RS11295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7318_RS11300	COG1388	LysM domain
A7318_RS11300	COG0741	lytic transglycosylase activity
A7318_RS11305	COG4166	transmembrane transport
A7318_RS11310	COG4166	transmembrane transport
A7318_RS11315	COG4174	ABC transporter (Permease)
A7318_RS11320	COG4239	(ABC) transporter, permease
A7318_RS11325	COG4172	Belongs to the ABC transporter superfamily
A7318_RS11330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7318_RS11340	COG4174	ABC transporter (Permease)
A7318_RS11345	COG4239	(ABC) transporter, permease
A7318_RS11350	COG4172	Belongs to the ABC transporter superfamily
A7318_RS11355	COG3290	protein histidine kinase activity
A7318_RS11355	COG3829	transcription factor binding
A7318_RS11360	COG2610	gluconate transmembrane transporter activity
A7318_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS11370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7318_RS11380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7318_RS11385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7318_RS11410	COG0765	amino acid transport
A7318_RS11415	COG0765	amino acid transport
A7318_RS11435	COG1253	flavin adenine dinucleotide binding
A7318_RS11450	COG0616	signal peptide processing
A7318_RS11490	COG3706	GGDEF domain
A7318_RS11490	COG4251	negative regulation of phosphorylation
A7318_RS11490	COG5001	Diguanylate cyclase
A7318_RS11490	COG2203	Gaf domain
A7318_RS11505	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7318_RS11515	COG0583	DNA-binding transcription factor activity
A7318_RS11525	COG4774	siderophore transport
A7318_RS11575	COG0840	transmembrane signaling receptor activity
A7318_RS11585	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS11590	COG1129	ABC transporter
A7318_RS11600	COG0673	inositol 2-dehydrogenase activity
A7318_RS11605	COG0673	inositol 2-dehydrogenase activity
A7318_RS11610	COG3962	Belongs to the TPP enzyme family
A7318_RS11620	COG3718	enzyme involved in inositol metabolism
A7318_RS11630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7318_RS11640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7318_RS11645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS11675	COG0745	RESPONSE REGULATOR receiver
A7318_RS11680	COG5002	protein histidine kinase activity
A7318_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS11700	COG0583	DNA-binding transcription factor activity
A7318_RS11705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS11715	COG0174	glutamine synthetase
A7318_RS11730	COG2814	Major facilitator Superfamily
A7318_RS11740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7318_RS11745	COG1522	sequence-specific DNA binding
A7318_RS11760	COG0577	efflux transmembrane transporter activity
A7318_RS11760	COG1136	(ABC) transporter
A7318_RS11765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS11775	COG1968	undecaprenyl-diphosphatase activity
A7318_RS11780	COG0840	transmembrane signaling receptor activity
A7318_RS11795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7318_RS11810	COG1309	transcriptional regulator
A7318_RS11815	COG2010	Cytochrome c
A7318_RS11815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7318_RS11820	COG2080	2 iron, 2 sulfur cluster binding
A7318_RS11825	COG1846	Transcriptional regulator
A7318_RS11830	COG2309	aminopeptidase activity
A7318_RS11835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7318_RS11840	COG0596	Alpha beta hydrolase
A7318_RS11845	COG3473	Maleate cis-trans isomerase
A7318_RS11850	COG1335	isochorismatase
A7318_RS11855	COG2271	Major facilitator Superfamily
A7318_RS11865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A7318_RS11880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7318_RS11885	COG1116	anion transmembrane transporter activity
A7318_RS11890	COG3712	iron ion homeostasis
A7318_RS11895	COG1595	DNA-templated transcription, initiation
A7318_RS11905	COG2271	Major facilitator Superfamily
A7318_RS11910	COG4948	Mandelate Racemase Muconate Lactonizing
A7318_RS11920	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS11930	COG3254	rhamnose metabolic process
A7318_RS11940	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS11950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7318_RS11990	COG0589	response to stress
A7318_RS12005	COG0662	Cupin 2, conserved barrel domain protein
A7318_RS12015	COG0745	RESPONSE REGULATOR receiver
A7318_RS12020	COG2205	protein histidine kinase activity
A7318_RS12030	COG3791	Glutathione-dependent formaldehyde-activating
A7318_RS12035	COG0714	Associated with various cellular activities
A7318_RS12055	COG0583	DNA-binding transcription factor activity
A7318_RS12060	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A7318_RS12065	COG1960	acyl-CoA dehydrogenase activity
A7318_RS12130	COG0697	spore germination
A7318_RS12135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS12170	COG3300	MHYT domain
A7318_RS12170	COG5001	Diguanylate cyclase
A7318_RS12175	COG2223	nitrite transmembrane transporter activity
A7318_RS12180	COG2207	Transcriptional regulator
A7318_RS12195	COG2207	Transcriptional regulator
A7318_RS12215	COG2271	Major facilitator Superfamily
A7318_RS12255	COG0243	molybdopterin cofactor binding
A7318_RS12260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7318_RS12260	COG2146	nitrite reductase [NAD(P)H] activity
A7318_RS12265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7318_RS12265	COG2146	nitrite reductase [NAD(P)H] activity
A7318_RS12285	COG1247	-acetyltransferase
A7318_RS12315	COG2808	Putative FMN-binding domain
A7318_RS12320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS12335	COG1309	transcriptional regulator
A7318_RS12345	COG1280	lysine exporter protein (LysE YggA)
A7318_RS12350	COG0840	transmembrane signaling receptor activity
A7318_RS12355	COG1944	ATP diphosphatase activity
A7318_RS12360	COG0626	cystathionine gamma-synthase activity
A7318_RS12370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7318_RS12405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A7318_RS12410	COG3011	Protein conserved in bacteria
A7318_RS12430	COG1522	sequence-specific DNA binding
A7318_RS12440	COG1113	amino acid transport
A7318_RS12450	COG3468	outer membrane autotransporter barrel domain protein
A7318_RS12495	COG1640	4-alpha-glucanotransferase
A7318_RS12500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7318_RS12505	COG0297	glycogen (starch) synthase activity
A7318_RS12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7318_RS12515	COG0596	Alpha beta hydrolase
A7318_RS12520	COG1238	metal cluster binding
A7318_RS12540	COG0667	Aldo Keto reductase
A7318_RS12545	COG0583	DNA-binding transcription factor activity
A7318_RS12560	COG2366	antibiotic biosynthetic process
A7318_RS12590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A7318_RS12790	COG3179	chitinase
A7318_RS12800	COG2246	polysaccharide biosynthetic process
A7318_RS12805	COG0463	Glycosyl transferase, family 2
A7318_RS12850	COG1397	ADP-ribosylglycohydrolase
A7318_RS12855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS12865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7318_RS12870	COG3938	Belongs to the proline racemase family
A7318_RS12875	COG0531	amino acid
A7318_RS12895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A7318_RS12905	COG0581	inorganic phosphate transmembrane transporter activity
A7318_RS12910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7318_RS12985	COG2207	Transcriptional regulator
A7318_RS12985	COG1917	Cupin 2, conserved barrel domain protein
A7318_RS12990	COG0431	NADPH-dependent FMN reductase
A7318_RS12995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7318_RS13005	COG0640	Transcriptional regulator
A7318_RS13015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7318_RS13045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A7318_RS13075	COG2169	Transcriptional regulator
A7318_RS13075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7318_RS13080	COG3145	DNA-N1-methyladenine dioxygenase activity
A7318_RS13155	COG2200	EAL domain
A7318_RS13160	COG0583	DNA-binding transcription factor activity
A7318_RS13180	COG0667	Aldo Keto reductase
A7318_RS13185	COG0583	DNA-binding transcription factor activity
A7318_RS13195	COG2271	Major facilitator Superfamily
A7318_RS13200	COG3835	regulator
A7318_RS13205	COG1929	Belongs to the glycerate kinase type-1 family
A7318_RS13210	COG5342	invasion associated locus B
A7318_RS13215	COG1247	-acetyltransferase
A7318_RS13220	COG1794	racemase activity, acting on amino acids and derivatives
A7318_RS13230	COG3278	Belongs to the heme-copper respiratory oxidase family
A7318_RS13260	COG0784	Response regulator, receiver
A7318_RS13260	COG2205	protein histidine kinase activity
A7318_RS13260	COG2198	Histidine kinase
A7318_RS13265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7318_RS13275	COG2205	protein histidine kinase activity
A7318_RS13275	COG0784	Response regulator, receiver
A7318_RS13295	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A7318_RS13305	COG3781	membrane
A7318_RS13320	COG1960	acyl-CoA dehydrogenase activity
A7318_RS13325	COG1024	Enoyl-CoA hydratase
A7318_RS13330	COG1960	acyl-CoA dehydrogenase activity
A7318_RS13335	COG1024	Enoyl-CoA hydratase
A7318_RS13360	COG2076	Multidrug Resistance protein
A7318_RS13365	COG2076	Multidrug Resistance protein
A7318_RS13370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7318_RS13375	COG0726	polysaccharide deacetylase
A7318_RS13380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7318_RS13380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7318_RS13385	COG0463	Glycosyl transferase, family 2
A7318_RS13395	COG4974	Belongs to the 'phage' integrase family
A7318_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS13405	COG2814	Major facilitator Superfamily
A7318_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS13425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A7318_RS13450	COG0826	peptidase U32
A7318_RS13460	COG1522	sequence-specific DNA binding
A7318_RS13470	COG1070	Carbohydrate kinase
A7318_RS13475	COG1609	Transcriptional regulator
A7318_RS13480	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS13485	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS13495	COG2202	Pas domain
A7318_RS13495	COG2205	protein histidine kinase activity
A7318_RS13500	COG0784	Response regulator, receiver
A7318_RS13505	COG5001	Diguanylate cyclase
A7318_RS13505	COG1716	ATPase activity
A7318_RS13510	COG0583	DNA-binding transcription factor activity
A7318_RS13530	COG2207	Transcriptional regulator
A7318_RS13545	COG0697	spore germination
A7318_RS13590	COG2308	Evidence 4 Homologs of previously reported genes of
A7318_RS13600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7318_RS13610	COG0745	RESPONSE REGULATOR receiver
A7318_RS13620	COG2267	carboxylic ester hydrolase activity
A7318_RS13625	COG1199	ATP-dependent helicase activity
A7318_RS13640	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A7318_RS13675	COG1113	amino acid transport
A7318_RS13695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS13710	COG0210	DNA helicase
A7318_RS13725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS13735	COG3321	synthase
A7318_RS13735	COG0604	alcohol dehydrogenase
A7318_RS13750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7318_RS13755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS13760	COG0765	amino acid transport
A7318_RS13765	COG1126	abc transporter atp-binding protein
A7318_RS13775	COG1737	Transcriptional regulator
A7318_RS13785	COG3210	domain, Protein
A7318_RS13790	COG2831	hemolysin activation secretion protein
A7318_RS13805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A7318_RS13830	COG2963	transposase activity
A7318_RS13840	COG2801	Transposase and inactivated derivatives
A7318_RS13865	COG1942	4-Oxalocrotonate Tautomerase
A7318_RS13875	COG0778	Nitroreductase
A7318_RS13890	COG0583	DNA-binding transcription factor activity
A7318_RS13915	COG2814	Major facilitator Superfamily
A7318_RS13930	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A7318_RS13950	COG0747	negative chemotaxis
A7318_RS13955	COG0601	transmembrane transport
A7318_RS13960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7318_RS13970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS13995	COG0672	)-iron permease
A7318_RS14000	COG2822	iron ion transport
A7318_RS14010	COG2822	iron ion transport
A7318_RS14015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7318_RS14030	COG2133	pyrroloquinoline quinone binding
A7318_RS14040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A7318_RS14075	COG0488	(ABC) transporter
A7318_RS14090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7318_RS14095	COG0583	DNA-binding transcription factor activity
A7318_RS14110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7318_RS14125	COG0587	DNA-directed DNA polymerase activity
A7318_RS14130	COG4191	Histidine kinase
A7318_RS14130	COG0784	Response regulator, receiver
A7318_RS14150	COG5383	Protein conserved in bacteria
A7318_RS14175	COG0747	negative chemotaxis
A7318_RS14210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7318_RS14225	COG0673	inositol 2-dehydrogenase activity
A7318_RS14245	COG2066	Belongs to the glutaminase family
A7318_RS14255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS14260	COG1126	abc transporter atp-binding protein
A7318_RS14265	COG0765	amino acid transport
A7318_RS14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS14285	COG0019	diaminopimelate decarboxylase activity
A7318_RS14305	COG1175	transmembrane transport
A7318_RS14315	COG3842	ATPase activity
A7318_RS14320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7318_RS14345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A7318_RS14360	COG0625	glutathione transferase activity
A7318_RS14370	COG0477	Major facilitator Superfamily
A7318_RS14415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7318_RS14425	COG0596	Alpha beta hydrolase
A7318_RS14440	COG0656	L-ascorbic acid biosynthetic process
A7318_RS14485	COG2204	response regulator
A7318_RS14520	COG0515	serine threonine protein kinase
A7318_RS14530	COG3300	MHYT domain
A7318_RS14530	COG5001	Diguanylate cyclase
A7318_RS14550	COG2267	carboxylic ester hydrolase activity
A7318_RS14555	COG3239	Fatty acid desaturase
A7318_RS14570	COG2067	long-chain fatty acid transport protein
A7318_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS14590	COG0183	Belongs to the thiolase family
A7318_RS14595	COG0318	PFAM AMP-dependent synthetase and ligase
A7318_RS14600	COG0673	inositol 2-dehydrogenase activity
A7318_RS14625	COG2706	6-phosphogluconolactonase activity
A7318_RS14645	COG0420	3'-5' exonuclease activity
A7318_RS14685	COG0714	Associated with various cellular activities
A7318_RS14730	COG0519	Catalyzes the synthesis of GMP from XMP
A7318_RS14750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7318_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS14765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7318_RS14770	COG1335	isochorismatase
A7318_RS14780	COG0814	amino acid
A7318_RS14790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7318_RS14800	COG2814	Major facilitator Superfamily
A7318_RS14830	COG1959	2 iron, 2 sulfur cluster binding
A7318_RS14855	COG2267	carboxylic ester hydrolase activity
A7318_RS14875	COG3712	iron ion homeostasis
A7318_RS14880	COG1595	DNA-templated transcription, initiation
A7318_RS14900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7318_RS14905	COG0583	DNA-binding transcription factor activity
A7318_RS14915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7318_RS14920	COG2271	Major facilitator Superfamily
A7318_RS14925	COG1609	Transcriptional regulator
A7318_RS14945	COG2072	flavoprotein involved in K transport
A7318_RS14985	COG1999	signal sequence binding
A7318_RS15020	COG0693	protein deglycase activity
A7318_RS15040	COG1349	DNA-binding transcription factor activity
A7318_RS15045	COG1304	FMN binding
A7318_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS15060	COG0494	nUDIX hydrolase
A7318_RS15080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS15085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS15110	COG1741	Belongs to the pirin family
A7318_RS15130	COG4977	sequence-specific DNA binding
A7318_RS15130	COG1917	Cupin 2, conserved barrel domain protein
A7318_RS15145	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A7318_RS15150	COG1335	isochorismatase
A7318_RS15155	COG0583	DNA-binding transcription factor activity
A7318_RS15165	COG5002	protein histidine kinase activity
A7318_RS15165	COG3447	MASE1 domain protein
A7318_RS15165	COG5001	Diguanylate cyclase
A7318_RS15195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7318_RS15200	COG1960	acyl-CoA dehydrogenase activity
A7318_RS15210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS15215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS15230	COG0583	DNA-binding transcription factor activity
A7318_RS15260	COG2188	Transcriptional regulator
A7318_RS15265	COG1280	lysine exporter protein (LysE YggA)
A7318_RS15270	COG3706	GGDEF domain
A7318_RS15290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS15300	COG0577	efflux transmembrane transporter activity
A7318_RS15300	COG1136	(ABC) transporter
A7318_RS15305	COG1136	(ABC) transporter
A7318_RS15305	COG0577	efflux transmembrane transporter activity
A7318_RS15350	COG3220	belongs to the UPF0276 family
A7318_RS15365	COG0288	reversible hydration of carbon dioxide
A7318_RS15370	COG2814	Major facilitator Superfamily
A7318_RS15415	COG1007	ATP synthesis coupled electron transport
A7318_RS15430	COG0713	ATP synthesis coupled electron transport
A7318_RS15440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7318_RS15445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A7318_RS15450	COG1034	ATP synthesis coupled electron transport
A7318_RS15465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7318_RS15465	COG0649	NAD binding
A7318_RS15470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7318_RS15475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7318_RS15480	COG2224	Isocitrate lyase
A7318_RS15490	COG2153	protein acetylation
A7318_RS15495	COG2850	peptidyl-arginine hydroxylation
A7318_RS15505	COG2915	High frequency lysogenization protein hflD homolog
A7318_RS15510	COG0482	sulfurtransferase activity
A7318_RS15535	COG1278	Cold shock
A7318_RS15540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A7318_RS15545	COG0542	response to heat
A7318_RS15550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7318_RS15555	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A7318_RS15560	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A7318_RS15565	COG1674	ftsk spoiiie
A7318_RS15570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A7318_RS15575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A7318_RS15580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A7318_RS15585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7318_RS15590	COG1648	precorrin-2 dehydrogenase activity
A7318_RS15590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7318_RS15595	COG0435	Glutathione S-transferase
A7318_RS15600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7318_RS15605	COG2920	part of a sulfur-relay system
A7318_RS15625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7318_RS15630	COG3091	SprT-like family
A7318_RS15640	COG0037	tRNA processing
A7318_RS15660	COG1393	Belongs to the ArsC family
A7318_RS15680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7318_RS15685	COG2205	protein histidine kinase activity
A7318_RS15685	COG5002	protein histidine kinase activity
A7318_RS15685	COG0784	Response regulator, receiver
A7318_RS15705	COG0658	competence protein
A7318_RS15705	COG2333	competence protein COMEC
A7318_RS15710	COG0811	peptide transport
A7318_RS15720	COG1663	tetraacyldisaccharide 4'-kinase activity
A7318_RS15725	COG2835	tetraacyldisaccharide 4'-kinase activity
A7318_RS15730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A7318_RS15735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7318_RS15740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A7318_RS15770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A7318_RS15960	COG3179	chitinase
A7318_RS15975	COG2135	peptidase activity
A7318_RS16035	COG3081	Nucleoid-associated protein
A7318_RS16085	COG0038	chloride channel
A7318_RS16095	COG0251	oxidation-reduction process
A7318_RS16145	COG1595	DNA-templated transcription, initiation
A7318_RS16155	COG3284	Transcriptional regulator
A7318_RS16160	COG3842	ATPase activity
A7318_RS16165	COG3842	ATPase activity
A7318_RS16175	COG0395	ABC-type sugar transport system, permease component
A7318_RS16190	COG2207	Transcriptional regulator
A7318_RS16195	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS16205	COG3268	Saccharopine dehydrogenase
A7318_RS16245	COG2814	Major facilitator Superfamily
A7318_RS16250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7318_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS16270	COG1129	ABC transporter
A7318_RS16275	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS16280	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS16285	COG3959	Transketolase, thiamine diphosphate binding domain
A7318_RS16290	COG3958	Transketolase
A7318_RS16295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7318_RS16360	COG2111	Na H antiporter
A7318_RS16360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7318_RS16365	COG1006	Multisubunit Na H antiporter MnhC subunit
A7318_RS16370	COG0651	ATP synthesis coupled electron transport
A7318_RS16380	COG2212	antiporter activity
A7318_RS16385	COG1320	monovalent cation:proton antiporter activity
A7318_RS16395	COG1733	regulation of RNA biosynthetic process
A7318_RS16400	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS16405	COG0681	Belongs to the peptidase S26 family
A7318_RS16420	COG0215	cysteine-tRNA ligase activity
A7318_RS16425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7318_RS16435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A7318_RS16440	COG2814	Major facilitator Superfamily
A7318_RS16445	COG1566	PFAM secretion protein HlyD family protein
A7318_RS16455	COG1846	Transcriptional regulator
A7318_RS16460	COG2911	Protein conserved in bacteria
A7318_RS16465	COG0729	surface antigen
A7318_RS16475	COG0708	Exodeoxyribonuclease III
A7318_RS16500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7318_RS16520	COG0456	acetyltransferase
A7318_RS16525	COG1309	transcriptional regulator
A7318_RS16545	COG1953	Uracil, thiamine, allantoin
A7318_RS16560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS16580	COG1686	Belongs to the peptidase S11 family
A7318_RS16585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A7318_RS16610	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7318_RS16615	COG0740	serine-type endopeptidase activity
A7318_RS16620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7318_RS16625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A7318_RS16630	COG0776	regulation of translation
A7318_RS16635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7318_RS16645	COG2814	Major facilitator Superfamily
A7318_RS16650	COG0583	DNA-binding transcription factor activity
A7318_RS16660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7318_RS16665	COG1846	Transcriptional regulator
A7318_RS16670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7318_RS16685	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7318_RS16685	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS16695	COG3038	cytochrome b561
A7318_RS16700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7318_RS16705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A7318_RS16710	COG0583	DNA-binding transcription factor activity
A7318_RS16725	COG0217	transcriptional regulatory protein
A7318_RS16735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A7318_RS16790	COG3038	cytochrome b561
A7318_RS16795	COG2866	Carboxypeptidase
A7318_RS16820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7318_RS16825	COG1960	acyl-CoA dehydrogenase activity
A7318_RS16830	COG0318	PFAM AMP-dependent synthetase and ligase
A7318_RS16840	COG0789	Transcriptional regulator
A7318_RS16850	COG1960	acyl-CoA dehydrogenase activity
A7318_RS16855	COG2885	chlorophyll binding
A7318_RS16895	COG2186	Transcriptional regulator
A7318_RS16905	COG1538	Outer membrane efflux protein
A7318_RS16910	COG0577	efflux transmembrane transporter activity
A7318_RS16910	COG1136	(ABC) transporter
A7318_RS16915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS16945	COG2423	ornithine cyclodeaminase activity
A7318_RS16955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7318_RS16960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7318_RS16970	COG0022	dehydrogenase e1 component
A7318_RS16975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A7318_RS16980	COG1522	sequence-specific DNA binding
A7318_RS16990	COG0640	Transcriptional regulator
A7318_RS17005	COG0471	metal ion transport
A7318_RS17015	COG1609	Transcriptional regulator
A7318_RS17020	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS17025	COG1070	Carbohydrate kinase
A7318_RS17030	COG1063	alcohol dehydrogenase
A7318_RS17035	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS17045	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS17095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7318_RS17100	COG1129	ABC transporter
A7318_RS17130	COG0583	DNA-binding transcription factor activity
A7318_RS17140	COG0625	glutathione transferase activity
A7318_RS17145	COG0390	transport system, permease component
A7318_RS17150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7318_RS17155	COG0667	Aldo Keto reductase
A7318_RS17185	COG0784	Response regulator, receiver
A7318_RS17185	COG2205	protein histidine kinase activity
A7318_RS17190	COG2203	Gaf domain
A7318_RS17190	COG2200	EAL domain
A7318_RS17190	COG2199	diguanylate cyclase activity
A7318_RS17200	COG2197	response regulator
A7318_RS17210	COG3121	Chaperone
A7318_RS17230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS17235	COG0765	amino acid transport
A7318_RS17245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS17260	COG1231	oxidoreductase activity
A7318_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS17270	COG1126	abc transporter atp-binding protein
A7318_RS17285	COG1450	Type ii and iii secretion system protein
A7318_RS17300	COG3166	PFAM Fimbrial assembly family protein
A7318_RS17305	COG3156	type II secretion system protein K
A7318_RS17325	COG2165	general secretion pathway protein
A7318_RS17330	COG1459	type II secretion system
A7318_RS17335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7318_RS17340	COG1609	Transcriptional regulator
A7318_RS17350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS17355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS17370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS17380	COG0477	Major facilitator Superfamily
A7318_RS17400	COG5002	protein histidine kinase activity
A7318_RS17420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7318_RS17435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7318_RS17460	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS17465	COG1129	ABC transporter
A7318_RS17470	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS17475	COG1609	Transcriptional regulator
A7318_RS17480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7318_RS17485	COG1869	D-ribose catabolic process
A7318_RS17510	COG1278	Cold shock
A7318_RS17520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7318_RS17525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A7318_RS17530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7318_RS17535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7318_RS17540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7318_RS17545	COG0072	phenylalanine-tRNA ligase activity
A7318_RS17550	COG0776	regulation of translation
A7318_RS17605	COG2199	diguanylate cyclase activity
A7318_RS17610	COG1063	alcohol dehydrogenase
A7318_RS17620	COG1309	transcriptional regulator
A7318_RS17625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7318_RS17670	COG4774	siderophore transport
A7318_RS17675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A7318_RS17680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7318_RS17685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7318_RS17690	COG1120	ATPase activity
A7318_RS17720	COG1286	toxin biosynthetic process
A7318_RS17725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A7318_RS17730	COG0285	dihydrofolate synthase activity
A7318_RS17735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7318_RS17740	COG0135	phosphoribosylanthranilate isomerase activity
A7318_RS17765	COG0473	3-isopropylmalate dehydrogenase activity
A7318_RS17770	COG2226	methyltransferase
A7318_RS17775	COG0066	3-isopropylmalate dehydratase activity
A7318_RS17780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7318_RS17810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7318_RS17820	COG0596	Alpha beta hydrolase
A7318_RS17865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7318_RS17870	COG0556	nucleotide-excision repair
A7318_RS17885	COG0583	DNA-binding transcription factor activity
A7318_RS17890	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS17900	COG2814	Major facilitator Superfamily
A7318_RS17915	COG3591	Belongs to the peptidase S1B family
A7318_RS17915	COG1864	DNA RNA non-specific endonuclease
A7318_RS17930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7318_RS17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7318_RS17940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7318_RS17965	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A7318_RS17995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS18005	COG1280	lysine exporter protein (LysE YggA)
A7318_RS18030	COG0840	transmembrane signaling receptor activity
A7318_RS18035	COG2384	SAM-dependent methyltransferase
A7318_RS18040	COG2186	Transcriptional regulator
A7318_RS18055	COG4521	taurine ABC transporter
A7318_RS18065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7318_RS18085	COG5285	phytanoyl-CoA dioxygenase
A7318_RS18090	COG1126	abc transporter atp-binding protein
A7318_RS18095	COG0583	DNA-binding transcription factor activity
A7318_RS18120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7318_RS18135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS18140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7318_RS18150	COG2391	methyltransferase activity
A7318_RS18180	COG1309	transcriptional regulator
A7318_RS18215	COG0640	Transcriptional regulator
A7318_RS18265	COG2135	peptidase activity
A7318_RS18300	COG0583	DNA-binding transcription factor activity
A7318_RS18305	COG1304	FMN binding
A7318_RS18320	COG5002	protein histidine kinase activity
A7318_RS18320	COG5001	Diguanylate cyclase
A7318_RS18335	COG1054	Belongs to the UPF0176 family
A7318_RS18340	COG0271	Belongs to the BolA IbaG family
A7318_RS18350	COG0114	fumarate hydratase activity
A7318_RS18355	COG0697	spore germination
A7318_RS18360	COG0183	Belongs to the thiolase family
A7318_RS18365	COG2326	polyphosphate kinase activity
A7318_RS18370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS18370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A7318_RS18380	COG0367	asparagine synthase
A7318_RS18385	COG0189	ligase activity
A7318_RS18385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7318_RS18390	COG1363	Peptidase, m42
A7318_RS18395	COG3089	Belongs to the UPF0270 family
A7318_RS18400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7318_RS18415	COG1368	sulfuric ester hydrolase activity
A7318_RS18435	COG0318	PFAM AMP-dependent synthetase and ligase
A7318_RS18445	COG2197	response regulator
A7318_RS18450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A7318_RS18460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A7318_RS18465	COG1073	alpha beta
A7318_RS18490	COG2840	Smr protein MutS2
A7318_RS18495	COG0302	gtp cyclohydrolase
A7318_RS18515	COG2851	Citrate transporter
A7318_RS18520	COG0583	DNA-binding transcription factor activity
A7318_RS18525	COG0625	glutathione transferase activity
A7318_RS18530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS18540	COG2252	PERMEase
A7318_RS18570	COG4266	Belongs to the allantoicase family
A7318_RS18575	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A7318_RS18585	COG2233	PERMEase
A7318_RS18600	COG1560	Kdo2-lipid A biosynthetic process
A7318_RS18605	COG0850	regulation of cytokinetic process
A7318_RS18610	COG2894	cell division
A7318_RS18615	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A7318_RS18620	COG0564	pseudouridine synthase activity
A7318_RS18625	COG1362	aminopeptidase activity
A7318_RS18630	COG0668	transmembrane transport
A7318_RS18665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7318_RS18695	COG1309	transcriptional regulator
A7318_RS18710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7318_RS18715	COG1960	acyl-CoA dehydrogenase activity
A7318_RS18720	COG1024	Enoyl-CoA hydratase
A7318_RS18735	COG3123	guanosine phosphorylase activity
A7318_RS18740	COG0633	Ferredoxin
A7318_RS18740	COG3217	Mosc domain protein beta barrel domain protein
A7318_RS18760	COG2197	response regulator
A7318_RS18765	COG1597	lipid kinase activity
A7318_RS18775	COG0835	chemotaxis
A7318_RS18785	COG1192	Involved in chromosome partitioning
A7318_RS18790	COG1360	Flagellar Motor Protein
A7318_RS18795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A7318_RS18800	COG2201	protein-glutamate methylesterase activity
A7318_RS18805	COG0643	Histidine kinase
A7318_RS18805	COG0784	Response regulator, receiver
A7318_RS18805	COG2198	Histidine kinase
A7318_RS18810	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A7318_RS18840	COG1278	Cold shock
A7318_RS18855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7318_RS18905	COG0745	RESPONSE REGULATOR receiver
A7318_RS18940	COG1677	Flagellar hook-basal body complex protein FliE
A7318_RS18985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A7318_RS19005	COG1706	bacterial-type flagellum-dependent cell motility
A7318_RS19010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A7318_RS19020	COG4787	bacterial-type flagellum-dependent cell motility
A7318_RS19025	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A7318_RS19035	COG2154	pterin-4-alpha-carbinolamine dehydratase
A7318_RS19050	COG2207	Transcriptional regulator
A7318_RS19070	COG1752	Esterase of the alpha-beta hydrolase superfamily
A7318_RS19075	COG1846	Transcriptional regulator
A7318_RS19080	COG0514	ATP-dependent DNA helicase (RecQ)
A7318_RS19090	COG2832	Protein of unknown function (DUF454)
A7318_RS19095	COG0784	Response regulator, receiver
A7318_RS19095	COG5002	protein histidine kinase activity
A7318_RS19145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A7318_RS19150	COG0406	alpha-ribazole phosphatase activity
A7318_RS19155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7318_RS19165	COG1492	cobalamin metabolic process
A7318_RS19175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A7318_RS19180	COG0778	Nitroreductase
A7318_RS19185	COG1797	cobyrinic acid a,c-diamide synthase activity
A7318_RS19200	COG0791	NLP P60 protein
A7318_RS19205	COG0791	NLP P60 protein
A7318_RS19210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7318_RS19215	COG0628	permease
A7318_RS19225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7318_RS19230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A7318_RS19245	COG3122	Protein conserved in bacteria
A7318_RS19250	COG3956	TIGRFAM MazG family protein
A7318_RS19255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7318_RS19260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7318_RS19295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7318_RS19315	COG0583	DNA-binding transcription factor activity
A7318_RS19320	COG0583	DNA-binding transcription factor activity
A7318_RS19330	COG1953	Uracil, thiamine, allantoin
A7318_RS19340	COG2996	Protein conserved in bacteria
A7318_RS19370	COG0513	Belongs to the DEAD box helicase family
A7318_RS19375	COG0668	transmembrane transport
A7318_RS19385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7318_RS19410	COG1132	(ABC) transporter
A7318_RS19420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7318_RS19440	COG2188	Transcriptional regulator
A7318_RS19450	COG1595	DNA-templated transcription, initiation
A7318_RS19460	COG1643	Atp-dependent helicase
A7318_RS19470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A7318_RS19495	COG0840	transmembrane signaling receptor activity
A7318_RS19505	COG3278	Belongs to the heme-copper respiratory oxidase family
A7318_RS19525	COG3278	Belongs to the heme-copper respiratory oxidase family
A7318_RS19540	COG2010	Cytochrome c
A7318_RS19545	COG0348	domain, Protein
A7318_RS19580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7318_RS19585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7318_RS19590	COG1960	acyl-CoA dehydrogenase activity
A7318_RS19595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7318_RS19600	COG2130	NADP-dependent
A7318_RS19605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7318_RS19610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7318_RS19630	COG0583	DNA-binding transcription factor activity
A7318_RS19665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7318_RS19670	COG3115	cell septum assembly
A7318_RS19690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7318_RS19700	COG0402	S-adenosylhomocysteine deaminase activity
A7318_RS19705	COG1802	Transcriptional regulator
A7318_RS19710	COG3135	benzoate transporter
A7318_RS19715	COG3171	Protein conserved in bacteria
A7318_RS19730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7318_RS19730	COG0116	Belongs to the methyltransferase superfamily
A7318_RS19735	COG0167	dihydroorotate dehydrogenase activity
A7318_RS19755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS19755	COG1116	anion transmembrane transporter activity
A7318_RS19760	COG3707	response regulator
A7318_RS19765	COG2223	nitrite transmembrane transporter activity
A7318_RS19770	COG0515	serine threonine protein kinase
A7318_RS19770	COG2815	serine threonine protein kinase
A7318_RS19775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7318_RS19780	COG3047	cAMP biosynthetic process
A7318_RS19780	COG2885	chlorophyll binding
A7318_RS19805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7318_RS19820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A7318_RS19825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS19840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7318_RS19845	COG1045	serine acetyltransferase
A7318_RS19850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7318_RS19855	COG2079	MmgE PrpD family protein
A7318_RS19865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7318_RS19870	COG0372	Belongs to the citrate synthase family
A7318_RS19880	COG1802	Transcriptional regulator
A7318_RS19885	COG4067	protein conserved in archaea
A7318_RS19885	COG0189	ligase activity
A7318_RS19895	COG0189	ligase activity
A7318_RS19905	COG0560	Phosphoserine phosphatase
A7318_RS19915	COG1953	Uracil, thiamine, allantoin
A7318_RS19925	COG0583	DNA-binding transcription factor activity
A7318_RS19930	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS19935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7318_RS20090	COG4695	Portal protein
A7318_RS20135	COG0582	viral genome integration into host DNA
A7318_RS20160	COG0598	Magnesium transport protein CorA
A7318_RS20165	COG0519	Catalyzes the synthesis of GMP from XMP
A7318_RS20165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7318_RS20170	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7318_RS20170	COG1024	Enoyl-CoA hydratase
A7318_RS20175	COG0183	Belongs to the thiolase family
A7318_RS20185	COG1305	Transglutaminase-like
A7318_RS20195	COG2308	Evidence 4 Homologs of previously reported genes of
A7318_RS20225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS20230	COG2885	chlorophyll binding
A7318_RS20265	COG2207	Transcriptional regulator
A7318_RS20270	COG1064	alcohol dehydrogenase
A7318_RS20275	COG1414	Transcriptional regulator
A7318_RS20280	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7318_RS20285	COG1129	ABC transporter
A7318_RS20290	COG1879	ABC-type sugar transport system periplasmic component
A7318_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS20330	COG1397	ADP-ribosylglycohydrolase
A7318_RS20335	COG2188	Transcriptional regulator
A7318_RS20350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A7318_RS20360	COG0084	hydrolase, TatD family'
A7318_RS20370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A7318_RS20375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A7318_RS20385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7318_RS20390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7318_RS20405	COG0416	fatty acid biosynthetic process
A7318_RS20410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A7318_RS20415	COG1399	metal-binding, possibly nucleic acid-binding protein
A7318_RS20420	COG0424	maF-like protein
A7318_RS20425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7318_RS20425	COG0616	signal peptide processing
A7318_RS20430	COG0546	phosphoglycolate phosphatase activity
A7318_RS20440	COG1530	ribonuclease E activity
A7318_RS20450	COG3608	succinylglutamate desuccinylase aspartoacylase
A7318_RS20450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7318_RS20455	COG1301	dicarboxylic acid transport
A7318_RS20460	COG4977	sequence-specific DNA binding
A7318_RS20460	COG1917	Cupin 2, conserved barrel domain protein
A7318_RS20480	COG2977	Belongs to the P-Pant transferase superfamily
A7318_RS20485	COG2205	protein histidine kinase activity
A7318_RS20490	COG0745	RESPONSE REGULATOR receiver
A7318_RS20505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A7318_RS20510	COG1558	bacterial-type flagellum-dependent cell motility
A7318_RS20515	COG1815	bacterial-type flagellum-dependent cell motility
A7318_RS20520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A7318_RS20525	COG0784	Response regulator, receiver
A7318_RS20525	COG0835	chemotaxis
A7318_RS20545	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A7318_RS20550	COG0477	Major facilitator Superfamily
A7318_RS20575	COG2239	Acts as a magnesium transporter
A7318_RS20595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A7318_RS20600	COG0527	aspartate kinase activity
A7318_RS20605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7318_RS20610	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A7318_RS20615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7318_RS20620	COG2988	succinylglutamate desuccinylase activity
A7318_RS20630	COG3724	N-succinylarginine dihydrolase activity
A7318_RS20635	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS20650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7318_RS20685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS20690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7318_RS20715	COG0165	Argininosuccinate lyase
A7318_RS20720	COG0765	amino acid transport
A7318_RS20735	COG2814	Major facilitator Superfamily
A7318_RS20750	COG0154	amidase activity
A7318_RS20770	COG3706	GGDEF domain
A7318_RS20790	COG0504	CTP synthase activity
A7318_RS20795	COG2329	Antibiotic biosynthesis monooxygenase
A7318_RS20805	COG0584	glycerophosphoryl diester phosphodiesterase
A7318_RS20835	COG0306	phosphate transporter
A7318_RS20840	COG1984	allophanate hydrolase subunit 2
A7318_RS20850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7318_RS20860	COG0583	DNA-binding transcription factor activity
A7318_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS20880	COG0583	DNA-binding transcription factor activity
A7318_RS20885	COG0583	DNA-binding transcription factor activity
A7318_RS20890	COG4221	oxidoreductase activity
A7318_RS20895	COG4941	Belongs to the sigma-70 factor family
A7318_RS20905	COG3795	YCII-related domain
A7318_RS20930	COG0436	Aminotransferase
A7318_RS20940	COG3265	gluconokinase activity
A7318_RS20945	COG1609	Transcriptional regulator
A7318_RS20960	COG2271	Major facilitator Superfamily
A7318_RS20995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS21010	COG3712	iron ion homeostasis
A7318_RS21015	COG1595	DNA-templated transcription, initiation
A7318_RS21040	COG0242	peptide deformylase activity
A7318_RS21045	COG1295	ribonuclease BN
A7318_RS21065	COG0318	PFAM AMP-dependent synthetase and ligase
A7318_RS21075	COG2030	dehydratase
A7318_RS21085	COG3530	Putative quorum-sensing-regulated virulence factor
A7318_RS21090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7318_RS21095	COG0800	Aldolase
A7318_RS21110	COG1737	Transcriptional regulator
A7318_RS21115	COG0676	glucose-6-phosphate 1-epimerase activity
A7318_RS21125	COG3842	ATPase activity
A7318_RS21130	COG0395	ABC-type sugar transport system, permease component
A7318_RS21135	COG1175	transmembrane transport
A7318_RS21140	COG1653	transport
A7318_RS21145	COG2942	2-epimerase
A7318_RS21155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7318_RS21160	COG0583	DNA-binding transcription factor activity
A7318_RS21175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A7318_RS21195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A7318_RS21225	COG1113	amino acid transport
A7318_RS21245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7318_RS21255	COG0009	L-threonylcarbamoyladenylate synthase
A7318_RS21260	COG0613	PHP domain protein
A7318_RS21265	COG2917	probably involved in intracellular septation
A7318_RS21270	COG2350	Protein conserved in bacteria
A7318_RS21280	COG0745	RESPONSE REGULATOR receiver
A7318_RS21290	COG0642	Histidine kinase
A7318_RS21300	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7318_RS21305	COG1074	ATP-dependent DNA helicase activity
A7318_RS21310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7318_RS21350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A7318_RS21355	COG3483	tryptophan 2,3-dioxygenase activity
A7318_RS21360	COG1113	amino acid transport
A7318_RS21365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7318_RS21365	COG0543	2 iron, 2 sulfur cluster binding
A7318_RS21370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A7318_RS21375	COG4638	Rieske (2fe-2S)
A7318_RS21390	COG4948	Mandelate Racemase Muconate Lactonizing
A7318_RS21395	COG4829	muconolactone delta-isomerase
A7318_RS21400	COG3485	protocatechuate 3,4-dioxygenase
A7318_RS21405	COG1522	sequence-specific DNA binding
A7318_RS21415	COG1113	amino acid transport
A7318_RS21420	COG0583	DNA-binding transcription factor activity
A7318_RS21430	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7318_RS21435	COG0583	DNA-binding transcription factor activity
A7318_RS21445	COG0659	secondary active sulfate transmembrane transporter activity
A7318_RS21455	COG2610	gluconate transmembrane transporter activity
A7318_RS21465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A7318_RS21475	COG0840	transmembrane signaling receptor activity
A7318_RS21480	COG0545	Peptidyl-prolyl cis-trans isomerase
A7318_RS21485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7318_RS21490	COG2824	Alkylphosphonate utilization operon protein PhnA
A7318_RS21495	COG0142	geranyltranstransferase activity
A7318_RS21500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A7318_RS21505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7318_RS21510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7318_RS21515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7318_RS21520	COG3045	CreA protein
A7318_RS21525	COG0386	Belongs to the glutathione peroxidase family
A7318_RS21540	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A7318_RS21545	COG0492	ferredoxin-NADP+ reductase activity
A7318_RS21560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7318_RS21565	COG0302	gtp cyclohydrolase
A7318_RS21590	COG1366	Belongs to the anti-sigma-factor antagonist family
A7318_RS21600	COG0583	DNA-binding transcription factor activity
A7318_RS21605	COG1380	Effector of murein hydrolase LrgA
A7318_RS21610	COG1346	cytolysis
A7318_RS21625	COG1028	Short-chain dehydrogenase reductase Sdr
A7318_RS21640	COG2909	trisaccharide binding
A7318_RS21645	COG3708	Transcriptional regulator
A7318_RS21645	COG2207	Transcriptional regulator
A7318_RS21655	COG3604	Transcriptional regulator
A7318_RS21660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7318_RS21660	COG1017	nitric oxide dioxygenase activity
A7318_RS21665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A7318_RS21670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7318_RS21675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7318_RS21680	COG1845	cytochrome c oxidase, subunit III
A7318_RS21690	COG0109	protoheme IX farnesyltransferase activity
A7318_RS21695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7318_RS21705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7318_RS21710	COG0583	DNA-binding transcription factor activity
A7318_RS21715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS21735	COG4251	negative regulation of phosphorylation
A7318_RS21785	COG0642	Histidine kinase
A7318_RS21810	COG3311	Transcriptional regulator
A7318_RS21815	COG1569	PIN domain
A7318_RS21825	COG1280	lysine exporter protein (LysE YggA)
A7318_RS21850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A7318_RS21935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A7318_RS21940	COG0343	queuine tRNA-ribosyltransferase activity
A7318_RS21945	COG1862	Preprotein translocase
A7318_RS21960	COG3134	Outer membrane lipoprotein
A7318_RS21975	COG1045	serine acetyltransferase
A7318_RS21985	COG1104	cysteine desulfurase activity
A7318_RS21995	COG0316	Belongs to the HesB IscA family
A7318_RS22000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7318_RS22005	COG0443	Heat shock 70 kDa protein
A7318_RS22010	COG0633	Ferredoxin
A7318_RS22020	COG0105	UTP biosynthetic process
A7318_RS22025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7318_RS22035	COG1426	Protein conserved in bacteria
A7318_RS22040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7318_RS22045	COG0124	histidyl-tRNA synthetase
A7318_RS22060	COG1160	GTP binding
A7318_RS22065	COG0436	Aminotransferase
A7318_RS22070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7318_RS22075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7318_RS22080	COG0739	heme binding
A7318_RS22085	COG1570	exodeoxyribonuclease VII activity
A7318_RS22090	COG0583	DNA-binding transcription factor activity
A7318_RS22110	COG0519	Catalyzes the synthesis of GMP from XMP
A7318_RS22110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7318_RS22120	COG2188	Transcriptional regulator
A7318_RS22125	COG1263	PTS System
A7318_RS22125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7318_RS22130	COG0366	Alpha amylase catalytic
A7318_RS22135	COG4580	involved in the transport of maltose and maltodextrins
A7318_RS22140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7318_RS22140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7318_RS22150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A7318_RS22155	COG0047	phosphoribosylformylglycinamidine synthase activity
A7318_RS22155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7318_RS22160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A7318_RS22165	COG2190	(PTS) system
A7318_RS22165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7318_RS22165	COG1263	PTS System
A7318_RS22170	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7318_RS22170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7318_RS22175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7318_RS22180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7318_RS22185	COG2188	Transcriptional regulator
A7318_RS22200	COG0494	nUDIX hydrolase
A7318_RS22215	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7318_RS22220	COG0477	Major facilitator Superfamily
A7318_RS22225	COG4536	flavin adenine dinucleotide binding
A7318_RS22235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7318_RS22240	COG0228	four-way junction DNA binding
A7318_RS22245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A7318_RS22250	COG0336	Belongs to the RNA methyltransferase TrmD family
A7318_RS22255	COG0335	large ribosomal subunit rRNA binding
A7318_RS22260	COG1607	acyl-coa hydrolase
A7318_RS22265	COG4974	Belongs to the 'phage' integrase family
A7318_RS22295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7318_RS22325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7318_RS22335	COG0442	prolyl-tRNA aminoacylation
A7318_RS22340	COG2211	Major facilitator Superfamily
A7318_RS22365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7318_RS22370	COG0459	protein refolding
A7318_RS22380	COG0642	Histidine kinase
A7318_RS22390	COG3642	lipopolysaccharide core region biosynthetic process
A7318_RS22400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7318_RS22405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS22430	COG0840	transmembrane signaling receptor activity
A7318_RS22435	COG2832	Protein of unknown function (DUF454)
A7318_RS22445	COG4771	TonB-dependent receptor
A7318_RS22450	COG3712	iron ion homeostasis
A7318_RS22455	COG1595	DNA-templated transcription, initiation
A7318_RS22485	COG2207	Transcriptional regulator
A7318_RS22505	COG0477	Major facilitator Superfamily
A7318_RS22515	COG4191	Histidine kinase
A7318_RS22530	COG1024	Enoyl-CoA hydratase
A7318_RS22535	COG0469	pyruvate kinase activity
A7318_RS22555	COG0714	Associated with various cellular activities
A7318_RS22580	COG2925	Exonuclease
A7318_RS22590	COG0788	formyltetrahydrofolate deformylase activity
A7318_RS22600	COG0433	COG0433 Predicted ATPase
A7318_RS22610	COG0653	protein targeting
A7318_RS22615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7318_RS22625	COG2096	Adenosyltransferase
A7318_RS22630	COG4191	Histidine kinase
A7318_RS22630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS22640	COG1666	GTP binding
A7318_RS22645	COG0668	transmembrane transport
A7318_RS22660	COG2900	Belongs to the SlyX family
A7318_RS22670	COG0783	Belongs to the Dps family
A7318_RS22685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7318_RS22690	COG0217	transcriptional regulatory protein
A7318_RS22695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A7318_RS22700	COG0632	four-way junction helicase activity
A7318_RS22705	COG2255	four-way junction helicase activity
A7318_RS22710	COG0824	Thioesterase
A7318_RS22730	COG0823	Involved in the tonB-independent uptake of proteins
A7318_RS22735	COG2885	chlorophyll binding
A7318_RS22740	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A7318_RS22745	COG0602	queuosine metabolic process
A7318_RS22750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A7318_RS22770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7318_RS22780	COG1278	Cold shock
A7318_RS22785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7318_RS22790	COG1760	l-serine dehydratase
A7318_RS22795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7318_RS22795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7318_RS22800	COG0509	glycine decarboxylation via glycine cleavage system
A7318_RS22850	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A7318_RS22855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A7318_RS22860	COG1183	phosphatidylcholine synthase activity
A7318_RS22865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A7318_RS22875	COG0028	Belongs to the TPP enzyme family
A7318_RS22880	COG3098	single-species biofilm formation
A7318_RS22890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7318_RS22910	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A7318_RS22915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7318_RS22920	COG4558	Periplasmic binding protein
A7318_RS22930	COG1489	DNA binding
A7318_RS22935	COG0436	Aminotransferase
A7318_RS22945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7318_RS22950	COG4191	Histidine kinase
A7318_RS22960	COG0617	tRNA 3'-terminal CCA addition
A7318_RS22970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A7318_RS22975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A7318_RS22980	COG0166	Belongs to the GPI family
A7318_RS22985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7318_RS22995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7318_RS23005	COG2823	Periplasmic or secreted lipoprotein
A7318_RS23010	COG1185	polyribonucleotide nucleotidyltransferase activity
A7318_RS23015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7318_RS23020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A7318_RS23025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7318_RS23030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A7318_RS23035	COG0195	Participates in both transcription termination and antitermination
A7318_RS23040	COG0779	Required for maturation of 30S ribosomal subunits
A7318_RS23055	COG0149	triose-phosphate isomerase activity
A7318_RS23060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7318_RS23065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A7318_RS23075	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A7318_RS23090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7318_RS23095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7318_RS23100	COG0505	Belongs to the CarA family
A7318_RS23105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7318_RS23110	COG0484	heat shock protein binding
A7318_RS23115	COG0443	Heat shock 70 kDa protein
A7318_RS23120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7318_RS23125	COG0497	DNA recombination
A7318_RS23130	COG0735	belongs to the Fur family
A7318_RS23135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7318_RS23140	COG2914	Belongs to the UPF0125 (RnfH) family
A7318_RS23150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7318_RS23155	COG2186	Transcriptional regulator
A7318_RS23160	COG1620	l-lactate permease
A7318_RS23180	COG0582	viral genome integration into host DNA
A7318_RS23185	COG4983	Phage plasmid primase, P4 family domain protein
A7318_RS23240	COG0732	type I restriction modification DNA specificity domain
A7318_RS23260	COG2862	Uncharacterized protein family, UPF0114
A7318_RS23275	COG1067	ATP-dependent peptidase activity
A7318_RS23295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7318_RS23305	COG0488	(ABC) transporter
A7318_RS23320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7318_RS23325	COG0523	cobalamin synthesis protein
A7318_RS23330	COG2879	small protein
A7318_RS23335	COG1966	Carbon starvation protein
A7318_RS23360	COG1970	mechanosensitive ion channel activity
A7318_RS23370	COG2197	response regulator
A7318_RS23375	COG2813	Specifically methylates the guanine in position
A7318_RS23385	COG1294	oxidase, subunit
A7318_RS23390	COG1271	oxidase subunit
A7318_RS23400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7318_RS23405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A7318_RS23410	COG2080	2 iron, 2 sulfur cluster binding
A7318_RS23420	COG2252	PERMEase
A7318_RS23425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7318_RS23450	COG4206	TonB-dependent receptor
A7318_RS23450	COG1629	transport
A7318_RS23465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A7318_RS23505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7318_RS23510	COG0081	regulation of translation
A7318_RS23515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7318_RS23520	COG0222	ribosome binding
A7318_RS23525	COG0085	RNA polymerase activity
A7318_RS23530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7318_RS23535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A7318_RS23540	COG0049	tRNA binding
A7318_RS23545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7318_RS23550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7318_RS23555	COG0051	transcription antitermination factor activity, RNA binding
A7318_RS23560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7318_RS23565	COG0088	Forms part of the polypeptide exit tunnel
A7318_RS23570	COG0089	rRNA binding
A7318_RS23575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7318_RS23580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7318_RS23585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7318_RS23590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7318_RS23595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7318_RS23600	COG0255	Belongs to the universal ribosomal protein uL29 family
A7318_RS23605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7318_RS23610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7318_RS23615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A7318_RS23620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7318_RS23625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7318_RS23630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7318_RS23635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7318_RS23640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7318_RS23645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7318_RS23650	COG1841	ribosomal large subunit assembly
A7318_RS23655	COG0200	Binds to the 23S rRNA
A7318_RS23665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7318_RS23670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7318_RS23675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7318_RS23680	COG0202	RNA polymerase activity
A7318_RS23685	COG0203	ribosomal protein L17
A7318_RS23695	COG2193	ferroxidase activity
A7318_RS23700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A7318_RS23705	COG2814	Major facilitator Superfamily
A7318_RS23710	COG0629	single-stranded DNA binding
A7318_RS23745	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
A7318_RS23820	COG0583	DNA-binding transcription factor activity
A7318_RS23825	COG4106	trans-aconitate 2-methyltransferase activity
A7318_RS23830	COG1335	isochorismatase
A7318_RS23850	COG0392	lysyltransferase activity
A7318_RS23855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7318_RS23860	COG3568	Endonuclease Exonuclease Phosphatase
A7318_RS23865	COG2814	Major facilitator Superfamily
A7318_RS23870	COG0668	transmembrane transport
A7318_RS23875	COG1201	RNA secondary structure unwinding
A7318_RS23900	COG4181	ATPase activity
A7318_RS23915	COG3118	belongs to the thioredoxin family
A7318_RS23920	COG2264	protein methyltransferase activity
A7318_RS23930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A7318_RS23935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7318_RS23935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A7318_RS23950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7318_RS23955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A7318_RS23960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A7318_RS23970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7318_RS23985	COG4206	TonB-dependent receptor
A7318_RS23990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A7318_RS23995	COG0142	geranyltranstransferase activity
A7318_RS24000	COG1722	exodeoxyribonuclease VII activity
A7318_RS24005	COG0789	Transcriptional regulator
A7318_RS24010	COG2249	NAD(P)H dehydrogenase (quinone) activity
A7318_RS24015	COG1335	isochorismatase
A7318_RS24025	COG1842	Phage shock protein A
A7318_RS24045	COG3766	membrane
A7318_RS24055	COG0754	glutathionylspermidine amidase activity
A7318_RS24065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A7318_RS24070	COG3228	Belongs to the MtfA family
A7318_RS24075	COG0586	Pfam SNARE associated Golgi protein
A7318_RS24080	COG0456	acetyltransferase
A7318_RS24085	COG4302	ethanolamine ammonia-lyase activity
A7318_RS24090	COG4303	Ethanolamine ammonia lyase large subunit
A7318_RS24095	COG0531	amino acid
A7318_RS24105	COG3284	Transcriptional regulator
A7318_RS24110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A7318_RS24125	COG0702	epimerase
A7318_RS24145	COG1346	cytolysis
A7318_RS24155	COG0586	Pfam SNARE associated Golgi protein
A7318_RS24160	COG2094	Belongs to the DNA glycosylase MPG family
A7318_RS24165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7318_RS24170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7318_RS24180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A7318_RS24185	COG0768	penicillin binding
A7318_RS24190	COG0772	Belongs to the SEDS family
A7318_RS24195	COG2951	lytic endotransglycosylase activity
A7318_RS24205	COG1686	Belongs to the peptidase S11 family
A7318_RS24210	COG2921	Belongs to the UPF0250 family
A7318_RS24215	COG0321	lipoyl(octanoyl) transferase activity
A7318_RS24220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7318_RS24230	COG2951	lytic endotransglycosylase activity
A7318_RS24240	COG1466	dna polymerase III delta subunit
A7318_RS24250	COG0495	leucyl-tRNA aminoacylation
A7318_RS24265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A7318_RS24270	COG4535	Mg2 and Co2 transporter CorC
A7318_RS24275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7318_RS24280	COG1702	phosphate starvation-inducible protein PhoH
A7318_RS24285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7318_RS24300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7318_RS24305	COG0352	thiamine-phosphate diphosphorylase activity
A7318_RS24315	COG2205	protein histidine kinase activity
A7318_RS24315	COG2198	Histidine kinase
A7318_RS24315	COG0784	Response regulator, receiver
A7318_RS24320	COG1960	acyl-CoA dehydrogenase activity
A7318_RS24325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A7318_RS24340	COG1522	sequence-specific DNA binding
A7318_RS24350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A7318_RS24360	COG1643	Atp-dependent helicase
A7318_RS24375	COG3416	Protein conserved in bacteria
A7318_RS24385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7318_RS24385	COG1199	ATP-dependent helicase activity
A7318_RS24390	COG1522	sequence-specific DNA binding
A7318_RS24395	COG0697	spore germination
A7318_RS24400	COG0513	Belongs to the DEAD box helicase family
A7318_RS24405	COG2081	HI0933 family
A7318_RS24410	COG0123	including yeast histone deacetylase and acetoin utilization protein
A7318_RS24420	COG1946	Acyl-CoA thioesterase
A7318_RS24435	COG2321	neutral zinc metallopeptidase
A7318_RS24450	COG0477	Major facilitator Superfamily
A7318_RS24455	COG1082	Xylose isomerase domain protein TIM barrel
A7318_RS24455	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A7318_RS24460	COG1309	transcriptional regulator
A7318_RS24465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7318_RS24470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A7318_RS24490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A7318_RS24495	COG0739	heme binding
A7318_RS24500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A7318_RS24505	COG0316	Belongs to the HesB IscA family
A7318_RS24510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7318_RS24515	COG1981	membrane
A7318_RS24535	COG0537	adenosine 5'-monophosphoramidase activity
A7318_RS24540	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A7318_RS24545	COG1765	OsmC-like protein
A7318_RS24560	COG0134	indole-3-glycerol-phosphate synthase activity
A7318_RS24565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7318_RS24570	COG0512	Glutamine amidotransferase of anthranilate synthase
A7318_RS24575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7318_RS24580	COG0546	phosphoglycolate phosphatase activity
A7318_RS24585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A7318_RS24590	COG1454	alcohol dehydrogenase
A7318_RS24600	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7318_RS24610	COG3842	ATPase activity
A7318_RS24615	COG2197	response regulator
A7318_RS24630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A7318_RS24635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A7318_RS24640	COG3178	'Phosphotransferase
A7318_RS24645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A7318_RS24650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A7318_RS24655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A7318_RS24660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A7318_RS24665	COG2967	ApaG domain
A7318_RS24670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7318_RS24675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7318_RS24680	COG2766	serine protein kinase
A7318_RS24685	COG2718	Belongs to the UPF0229 family
A7318_RS24690	COG2719	SpoVR family
A7318_RS24695	COG0617	tRNA 3'-terminal CCA addition
A7318_RS24705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A7318_RS24710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A7318_RS24715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7318_RS24725	COG0358	DNA primase activity
A7318_RS24730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A7318_RS24750	COG0583	DNA-binding transcription factor activity
A7318_RS24765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7318_RS24770	COG1025	Belongs to the peptidase M16 family
A7318_RS24775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7318_RS24780	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A7318_RS24790	COG0535	radical SAM domain protein
A7318_RS24800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7318_RS24805	COG0583	DNA-binding transcription factor activity
A7318_RS24810	COG1960	acyl-CoA dehydrogenase activity
A7318_RS24815	COG1960	acyl-CoA dehydrogenase activity
A7318_RS24825	COG1960	acyl-CoA dehydrogenase activity
A7318_RS24845	COG1073	alpha beta
A7318_RS24845	COG2226	methyltransferase
A7318_RS24850	COG0156	8-amino-7-oxononanoate synthase activity
A7318_RS24855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7318_RS24865	COG3585	molybdate ion transport
A7318_RS24865	COG2005	Transcriptional regulator
A7318_RS24875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A7318_RS24890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A7318_RS24895	COG4566	intracellular signal transduction
A7318_RS24895	COG0745	RESPONSE REGULATOR receiver
A7318_RS24920	COG4774	siderophore transport
A7318_RS24935	COG4452	Inner membrane protein CreD
A7318_RS24940	COG2205	protein histidine kinase activity
A7318_RS24945	COG0745	RESPONSE REGULATOR receiver
A7318_RS24950	COG4067	protein conserved in archaea
A7318_RS24950	COG0189	ligase activity
A7318_RS24955	COG0204	Acyl-transferase
A7318_RS24965	COG1595	DNA-templated transcription, initiation
A7318_RS24980	COG1063	alcohol dehydrogenase
A7318_RS25010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7318_RS25030	COG1017	nitric oxide dioxygenase activity
A7318_RS25030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7318_RS25035	COG4638	Rieske (2fe-2S)
A7318_RS25045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A7318_RS25050	COG0247	lactate metabolic process
A7318_RS25050	COG2181	nitrate reductase activity
A7318_RS25055	COG1902	pentaerythritol trinitrate reductase activity
A7318_RS25055	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7318_RS25095	COG3246	L-lysine catabolic process to acetate
A7318_RS25100	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7318_RS25125	COG1760	l-serine dehydratase
A7318_RS25140	COG4175	Glycine betaine
A7318_RS25145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7318_RS25150	COG1309	transcriptional regulator
A7318_RS25155	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS25160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7318_RS25170	COG0312	modulator of DNA gyrase
A7318_RS25180	COG0477	Major facilitator Superfamily
A7318_RS25185	COG0513	Belongs to the DEAD box helicase family
A7318_RS25190	COG2081	HI0933 family
A7318_RS25195	COG1289	transmembrane transporter activity
A7318_RS25205	COG2153	protein acetylation
A7318_RS25215	COG1451	nucleotide metabolic process
A7318_RS25245	COG0126	phosphoglycerate kinase activity
A7318_RS25250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7318_RS25255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7318_RS25260	COG0640	Transcriptional regulator
A7318_RS25265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7318_RS25275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7318_RS25280	COG1422	Protein of unknown function (DUF1090)
A7318_RS25305	COG2116	formate transmembrane transporter activity
A7318_RS25320	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A7318_RS25325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A7318_RS25340	COG0513	Belongs to the DEAD box helicase family
A7318_RS25345	COG2353	YceI-like domain
A7318_RS25350	COG3038	cytochrome b561
A7318_RS25360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A7318_RS25365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS25385	COG1272	protein, Hemolysin III
A7318_RS25415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7318_RS25435	COG3052	prosthetic group binding
A7318_RS25440	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A7318_RS25460	COG3093	addiction module antidote protein HigA
A7318_RS25470	COG2198	Histidine kinase
A7318_RS25470	COG0784	Response regulator, receiver
A7318_RS25470	COG0643	Histidine kinase
A7318_RS25495	COG0189	ligase activity
A7318_RS25505	COG1678	Uncharacterized ACR, COG1678
A7318_RS25510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A7318_RS25515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7318_RS25520	COG0540	Belongs to the ATCase OTCase family
A7318_RS25525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7318_RS25535	COG0791	NLP P60 protein
A7318_RS25560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7318_RS25565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7318_RS25565	COG2813	Specifically methylates the guanine in position
A7318_RS25575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A7318_RS25580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7318_RS25590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7318_RS25595	COG2022	thiamine diphosphate biosynthetic process
A7318_RS25605	COG2363	Small membrane protein
A7318_RS25610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7318_RS25620	COG2177	Part of the ABC transporter FtsEX involved in
A7318_RS25625	COG2884	Cell division ATP-binding protein ftsE
A7318_RS25630	COG0552	protein localization to endoplasmic reticulum
A7318_RS25635	COG0612	Peptidase, M16
A7318_RS25640	COG0612	Peptidase, M16
A7318_RS25645	COG0742	ribosomal rna small subunit methyltransferase
A7318_RS25650	COG0429	hydrolase of the alpha beta-hydrolase fold
A7318_RS25660	COG1309	transcriptional regulator
A7318_RS25675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A7318_RS25680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7318_RS25685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A7318_RS25690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7318_RS25700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A7318_RS25705	COG2814	Major facilitator Superfamily
A7318_RS25710	COG0129	dihydroxy-acid dehydratase activity
A7318_RS25720	COG1823	symporter activity
A7318_RS25735	COG1160	GTP binding
A7318_RS25750	COG1840	ABC-type Fe3 transport system, periplasmic component
A7318_RS25755	COG1178	ABC-type Fe3 transport system permease component
A7318_RS25760	COG3842	ATPase activity
A7318_RS25765	COG0583	DNA-binding transcription factor activity
A7318_RS25775	COG0789	Transcriptional regulator
A7318_RS25780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A7318_RS25785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A7318_RS25790	COG0730	response to heat
A7318_RS25805	COG0494	nUDIX hydrolase
A7318_RS25820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7318_RS25825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A7318_RS25830	COG3204	pilus organization
A7318_RS25835	COG3204	pilus organization
A7318_RS25840	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7318_RS25845	COG0277	FAD linked oxidase domain protein
A7318_RS25850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7318_RS25860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS25865	COG1683	Conserved Protein
A7318_RS25895	COG4977	sequence-specific DNA binding
A7318_RS25895	COG1917	Cupin 2, conserved barrel domain protein
A7318_RS25900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7318_RS25915	COG1177	transmembrane transport
A7318_RS25920	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7318_RS25925	COG3842	ATPase activity
A7318_RS25945	COG0174	glutamine synthetase
A7318_RS25950	COG0174	glutamine synthetase
A7318_RS25965	COG1116	anion transmembrane transporter activity
A7318_RS25970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7318_RS25975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS25980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7318_RS25985	COG0431	NADPH-dependent FMN reductase
A7318_RS25990	COG0450	alkyl hydroperoxide reductase
A7318_RS26000	COG4521	taurine ABC transporter
A7318_RS26005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7318_RS26005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7318_RS26020	COG1522	sequence-specific DNA binding
A7318_RS26030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A7318_RS26035	COG0330	HflC and HflK could
A7318_RS26050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A7318_RS26055	COG0509	glycine decarboxylation via glycine cleavage system
A7318_RS26060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7318_RS26065	COG1178	ABC-type Fe3 transport system permease component
A7318_RS26075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7318_RS26085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7318_RS26090	COG0006	proline dipeptidase activity
A7318_RS26095	COG3079	Belongs to the UPF0149 family
A7318_RS26115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7318_RS26125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A7318_RS26130	COG1129	ABC transporter
A7318_RS26130	COG0842	Transport permease protein
A7318_RS26135	COG0842	Transport permease protein
A7318_RS26150	COG2271	Major facilitator Superfamily
A7318_RS26175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A7318_RS26195	COG2186	Transcriptional regulator
A7318_RS26200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7318_RS26205	COG0765	amino acid transport
A7318_RS26210	COG0765	amino acid transport
A7318_RS26225	COG3188	usher protein
A7318_RS26230	COG3121	Chaperone
A7318_RS26240	COG0248	Ppx GppA phosphatase
A7318_RS26245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7318_RS26255	COG0586	Pfam SNARE associated Golgi protein
A7318_RS26265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A7318_RS26270	COG1671	Belongs to the UPF0178 family
A7318_RS26275	COG0672	)-iron permease
A7318_RS26310	COG0488	(ABC) transporter
A7318_RS26340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A7318_RS26360	COG0181	hydroxymethylbilane synthase activity
A7318_RS26370	COG0165	Argininosuccinate lyase
A7318_RS26375	COG0625	glutathione transferase activity
A7318_RS26395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A7318_RS26405	COG1965	Belongs to the frataxin family
A7318_RS26410	COG0019	diaminopimelate decarboxylase activity
A7318_RS26415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7318_RS26425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A7318_RS26430	COG1011	Hydrolase
A7318_RS26440	COG0432	Pfam Uncharacterised protein family UPF0047
A7318_RS26445	COG0004	ammonium transporteR
A7318_RS26450	COG0347	Belongs to the P(II) protein family
A7318_RS26465	COG0606	chelatase, subunit chli
A7318_RS26470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A7318_RS26500	COG0606	chelatase, subunit chli
A7318_RS26505	COG0840	transmembrane signaling receptor activity
A7318_RS26510	COG0583	DNA-binding transcription factor activity
A7318_RS26515	COG0534	Mate efflux family protein
A7318_RS26530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7318_RS26535	COG0427	acetyl-CoA hydrolase
A7318_RS26550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7318_RS26555	COG0251	oxidation-reduction process
A7318_RS26560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS26575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7318_RS26585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7318_RS26590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7318_RS26600	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS26610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7318_RS26615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A7318_RS26620	COG0747	negative chemotaxis
A7318_RS26625	COG2003	Belongs to the UPF0758 family
A7318_RS26630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A7318_RS26635	COG0756	dUTP diphosphatase activity
A7318_RS26645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7318_RS26650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7318_RS26655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7318_RS26660	COG0708	Exodeoxyribonuclease III
A7318_RS26670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7318_RS26675	COG1561	YicC-like family, N-terminal region
A7318_RS26680	COG0194	GDP metabolic process
A7318_RS26685	COG1758	RNA polymerase activity
A7318_RS26690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7318_RS26715	COG0848	biopolymer transport protein
A7318_RS26725	COG0583	DNA-binding transcription factor activity
A7318_RS26730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A7318_RS26760	COG1136	(ABC) transporter
A7318_RS26765	COG2815	serine threonine protein kinase
A7318_RS26765	COG0515	serine threonine protein kinase
A7318_RS26855	COG3209	COG3209 Rhs family protein
A7318_RS26865	COG3209	COG3209 Rhs family protein
A7318_RS26900	COG3161	chorismate lyase activity
A7318_RS26905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7318_RS26925	COG1253	flavin adenine dinucleotide binding
A7318_RS26935	COG0704	Plays a role in the regulation of phosphate uptake
A7318_RS26940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7318_RS26945	COG0573	inorganic phosphate transmembrane transporter activity
A7318_RS26960	COG0477	Major facilitator Superfamily
A7318_RS26965	COG1607	acyl-coa hydrolase
A7318_RS26995	COG0583	DNA-binding transcription factor activity
A7318_RS27000	COG1027	Aspartate ammonia-lyase
A7318_RS27005	COG1115	amino acid carrier protein
A7318_RS27010	COG0252	asparaginase activity
A7318_RS27040	COG2808	Putative FMN-binding domain
A7318_RS27060	COG0511	ligase activity, forming carbon-carbon bonds
A7318_RS27060	COG5016	pyruvate
A7318_RS27065	COG0439	Biotin carboxylase
A7318_RS27070	COG0583	DNA-binding transcription factor activity
A7318_RS27080	COG5001	Diguanylate cyclase
A7318_RS27080	COG3300	MHYT domain
A7318_RS27085	COG0210	DNA helicase
A7318_RS27100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7318_RS27100	COG4651	solute:proton antiporter activity
A7318_RS27105	COG1607	acyl-coa hydrolase
A7318_RS27115	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A7318_RS27125	COG0523	cobalamin synthesis protein
A7318_RS27150	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7318_RS27155	COG1469	GTP cyclohydrolase I activity
A7318_RS27160	COG1121	(ABC) transporter
A7318_RS27175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7318_RS27185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7318_RS27195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7318_RS27200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7318_RS27210	COG3220	belongs to the UPF0276 family
A7318_RS27240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7318_RS27245	COG2267	carboxylic ester hydrolase activity
A7318_RS27250	COG2453	phosphatase
A7318_RS27250	COG0671	phosphoesterase, PA-phosphatase related
A7318_RS27265	COG4589	Belongs to the CDS family
A7318_RS27270	COG1522	sequence-specific DNA binding
A7318_RS27275	COG1280	lysine exporter protein (LysE YggA)
A7318_RS27280	COG2373	Large extracellular alpha-helical protein
A7318_RS27285	COG4953	penicillin-binding protein 1C
A7318_RS27295	COG3210	domain, Protein
A7318_RS27305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7318_RS27310	COG1349	DNA-binding transcription factor activity
A7318_RS27315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7318_RS27320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7318_RS27325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7318_RS27330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7318_RS27335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7318_RS27340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7318_RS27345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7318_RS27355	COG0356	it plays a direct role in the translocation of protons across the membrane
A7318_RS27360	COG3312	ion transport
A7318_RS27365	COG1475	DNA binding
A7318_RS27370	COG1192	Involved in chromosome partitioning
A7318_RS27375	COG0357	Ribosomal RNA small subunit methyltransferase G
A7318_RS27380	COG0445	tRNA wobble uridine modification
A7318_RS27385	COG1595	DNA-templated transcription, initiation
A7318_RS27390	COG3712	iron ion homeostasis
A7318_RS27395	COG4774	siderophore transport
A7318_RS27400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A7318_RS27405	COG0706	membrane insertase activity
A7318_RS27415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A7318_RS27420	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A7318_RS27425	COG0592	DNA-directed DNA polymerase activity
A7318_RS27430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7318_RS27435	COG0187	DNA topoisomerase II activity
A7318_RS27440	COG0745	RESPONSE REGULATOR receiver
A7318_RS27450	COG5002	protein histidine kinase activity
A7318_RS27460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7318_RS27465	COG0751	glycine-tRNA ligase activity
A7318_RS27470	COG0752	glycyl-tRNA synthetase alpha subunit
A7318_RS27475	COG2818	Glycosylase
A7318_RS27490	COG0569	domain protein
A7318_RS27495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A7318_RS27500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7318_RS27505	COG0242	peptide deformylase activity
A7318_RS27515	COG0758	DNA mediated transformation
A7318_RS27520	COG0009	L-threonylcarbamoyladenylate synthase
A7318_RS27530	COG0408	coproporphyrinogen oxidase activity
A7318_RS27535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7318_RS27550	COG3119	arylsulfatase activity
A7318_RS27555	COG0583	DNA-binding transcription factor activity
A7318_RS27565	COG3734	2-keto-3-deoxy-galactonokinase
A7318_RS27570	COG0800	Aldolase
A7318_RS27575	COG4948	Mandelate Racemase Muconate Lactonizing
A7318_RS27580	COG2271	Major facilitator Superfamily
A7318_RS27590	COG0159	tryptophan synthase activity
A7318_RS27610	COG3360	Dodecin
A7318_RS27620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7318_RS27625	COG1764	response to oxidative stress
A7318_RS27650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A7318_RS27655	COG0339	signal peptide processing
A7318_RS27695	COG0659	secondary active sulfate transmembrane transporter activity
A7318_RS27705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A7318_RS27710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7318_RS27715	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A7318_RS27745	COG0109	protoheme IX farnesyltransferase activity
A7318_RS27760	COG2011	ABC-type metal ion transport system permease component
A7318_RS27765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A7318_RS27780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7318_RS27785	COG1121	(ABC) transporter
A7318_RS27790	COG0735	belongs to the Fur family
A7318_RS27795	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A7318_RS27815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A7318_RS27820	COG3245	cytochrome
A7318_RS27830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7318_RS27845	COG3023	N-Acetylmuramoyl-L-alanine amidase
A7318_RS27850	COG5002	protein histidine kinase activity
A7318_RS27855	COG2204	response regulator
A7318_RS27865	COG5487	UPF0391 membrane protein
A7318_RS27875	COG1301	dicarboxylic acid transport
A7318_RS27880	COG0700	Nucleoside recognition
A7318_RS27895	COG1127	ABC transporter
A7318_RS27900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7318_RS27910	COG0612	Peptidase, M16
A7318_RS27915	COG1283	sodium-dependent phosphate transmembrane transporter activity
A7318_RS27920	COG0861	Integral membrane protein TerC family
A7318_RS27925	COG2851	Citrate transporter
A7318_RS27960	COG0427	acetyl-CoA hydrolase
A7318_RS27980	COG0583	DNA-binding transcription factor activity
A7318_RS27985	COG1960	acyl-CoA dehydrogenase activity
A7318_RS27990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7318_RS28125	COG1012	belongs to the aldehyde dehydrogenase family
A7318_RS28240	COG3210	domain, Protein
A7318_RS28285	COG1649	PFAM Uncharacterised BCR, COG1649
A7318_RS28285	COG0726	polysaccharide deacetylase
A7318_RS28290	COG1649	PFAM Uncharacterised BCR, COG1649
A7318_RS28290	COG0726	polysaccharide deacetylase