locus-tag	class	description
E4T63_RS00010	COG0592	DNA-directed DNA polymerase activity
E4T63_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4T63_RS00020	COG0187	DNA topoisomerase II activity
E4T63_RS00025	COG0745	RESPONSE REGULATOR receiver
E4T63_RS00030	COG5002	protein histidine kinase activity
E4T63_RS00040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4T63_RS00045	COG0751	glycine-tRNA ligase activity
E4T63_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
E4T63_RS00055	COG2818	Glycosylase
E4T63_RS00075	COG0569	domain protein
E4T63_RS00080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4T63_RS00085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4T63_RS00090	COG0242	peptide deformylase activity
E4T63_RS00100	COG0758	DNA mediated transformation
E4T63_RS00105	COG0009	L-threonylcarbamoyladenylate synthase
E4T63_RS00120	COG0408	coproporphyrinogen oxidase activity
E4T63_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4T63_RS00140	COG3119	arylsulfatase activity
E4T63_RS00145	COG0583	DNA-binding transcription factor activity
E4T63_RS00165	COG2851	Citrate transporter
E4T63_RS00170	COG0861	Integral membrane protein TerC family
E4T63_RS00180	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4T63_RS00185	COG0612	Peptidase, M16
E4T63_RS00200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4T63_RS00205	COG1127	ABC transporter
E4T63_RS00225	COG0700	Nucleoside recognition
E4T63_RS00230	COG1301	dicarboxylic acid transport
E4T63_RS00240	COG5487	UPF0391 membrane protein
E4T63_RS00250	COG2204	response regulator
E4T63_RS00255	COG5002	protein histidine kinase activity
E4T63_RS00260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4T63_RS00265	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4T63_RS00280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4T63_RS00290	COG3245	cytochrome
E4T63_RS00295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4T63_RS00315	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4T63_RS00320	COG0735	belongs to the Fur family
E4T63_RS00325	COG1121	(ABC) transporter
E4T63_RS00330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T63_RS00345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4T63_RS00350	COG2011	ABC-type metal ion transport system permease component
E4T63_RS00365	COG0109	protoheme IX farnesyltransferase activity
E4T63_RS00395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4T63_RS00400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T63_RS00405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T63_RS00415	COG0659	secondary active sulfate transmembrane transporter activity
E4T63_RS00455	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4T63_RS00460	COG0339	signal peptide processing
E4T63_RS00465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4T63_RS00495	COG1764	response to oxidative stress
E4T63_RS00500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T63_RS00515	COG3360	Dodecin
E4T63_RS00530	COG0133	tryptophan synthase activity
E4T63_RS00535	COG0159	tryptophan synthase activity
E4T63_RS00575	COG0427	acetyl-CoA hydrolase
E4T63_RS00595	COG0583	DNA-binding transcription factor activity
E4T63_RS00645	COG3328	transposase activity
E4T63_RS00660	COG3712	iron ion homeostasis
E4T63_RS00665	COG1595	DNA-templated transcription, initiation
E4T63_RS00670	COG0840	transmembrane signaling receptor activity
E4T63_RS00695	COG1802	Transcriptional regulator
E4T63_RS00705	COG5001	Diguanylate cyclase
E4T63_RS00705	COG3300	MHYT domain
E4T63_RS00720	COG1538	Outer membrane efflux protein
E4T63_RS00725	COG2274	protein secretion by the type I secretion system
E4T63_RS00730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS00735	COG2175	clavaminate synthase activity
E4T63_RS00745	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4T63_RS00750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS00775	COG1396	sequence-specific DNA binding
E4T63_RS00780	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E4T63_RS00835	COG0529	Catalyzes the synthesis of activated sulfate
E4T63_RS00850	COG0330	HflC and HflK could
E4T63_RS00875	COG1289	transmembrane transporter activity
E4T63_RS00885	COG1566	PFAM secretion protein HlyD family protein
E4T63_RS00900	COG5339	Protein conserved in bacteria
E4T63_RS00905	COG0457	Tetratricopeptide repeat
E4T63_RS00910	COG1649	PFAM Uncharacterised BCR, COG1649
E4T63_RS00910	COG0726	polysaccharide deacetylase
E4T63_RS00915	COG1215	transferase activity, transferring glycosyl groups
E4T63_RS00925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T63_RS00935	COG2304	oxidoreductase activity
E4T63_RS00940	COG1595	DNA-templated transcription, initiation
E4T63_RS00960	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS00965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T63_RS00975	COG2199	diguanylate cyclase activity
E4T63_RS00995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4T63_RS01005	COG4208	sulfate ABC transporter
E4T63_RS01010	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4T63_RS01075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS01080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T63_RS01105	COG4771	TonB-dependent receptor
E4T63_RS01150	COG3829	transcription factor binding
E4T63_RS01160	COG0765	amino acid transport
E4T63_RS01165	COG0765	amino acid transport
E4T63_RS01170	COG1126	abc transporter atp-binding protein
E4T63_RS01175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS01180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4T63_RS01195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T63_RS01205	COG2011	ABC-type metal ion transport system permease component
E4T63_RS01210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4T63_RS01215	COG1464	Belongs to the NlpA lipoprotein family
E4T63_RS01240	COG1126	abc transporter atp-binding protein
E4T63_RS01245	COG0765	amino acid transport
E4T63_RS01250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS01260	COG1045	serine acetyltransferase
E4T63_RS01265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T63_RS01275	COG1609	Transcriptional regulator
E4T63_RS01285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T63_RS01290	COG0667	Aldo Keto reductase
E4T63_RS01295	COG2175	clavaminate synthase activity
E4T63_RS01300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS01305	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4T63_RS01310	COG4521	taurine ABC transporter
E4T63_RS01315	COG2918	glutathione biosynthetic process
E4T63_RS01325	COG2183	response to ionizing radiation
E4T63_RS01340	COG0189	ligase activity
E4T63_RS01345	COG4067	protein conserved in archaea
E4T63_RS01345	COG0189	ligase activity
E4T63_RS01350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4T63_RS01360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4T63_RS01365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4T63_RS01375	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4T63_RS01405	COG1024	Enoyl-CoA hydratase
E4T63_RS01405	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T63_RS01420	COG0243	molybdopterin cofactor binding
E4T63_RS01425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4T63_RS01430	COG1652	LysM domain
E4T63_RS01435	COG1011	Hydrolase
E4T63_RS01440	COG0494	nUDIX hydrolase
E4T63_RS01445	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4T63_RS01470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4T63_RS01475	COG2957	Belongs to the agmatine deiminase family
E4T63_RS01530	COG5642	Protein of unknown function (DUF2384)
E4T63_RS01545	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4T63_RS01585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS01645	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4T63_RS01650	COG1194	a g-specific adenine glycosylase
E4T63_RS01665	COG2223	nitrite transmembrane transporter activity
E4T63_RS01670	COG0131	Imidazoleglycerol-phosphate dehydratase
E4T63_RS01675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4T63_RS01685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4T63_RS01690	COG0107	imidazoleglycerol-phosphate synthase activity
E4T63_RS01710	COG2861	carbohydrate metabolic process
E4T63_RS01715	COG0793	Belongs to the peptidase S41A family
E4T63_RS01720	COG4942	peptidase
E4T63_RS01725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4T63_RS01740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4T63_RS01745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4T63_RS01760	COG3852	Histidine kinase
E4T63_RS01785	COG0301	tRNA thio-modification
E4T63_RS01785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T63_RS01790	COG1217	gtp-binding protein TYPA
E4T63_RS01800	COG0058	SHG alpha-glucan phosphorylase activity
E4T63_RS01820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4T63_RS01840	COG3040	lipid binding
E4T63_RS01845	COG0402	S-adenosylhomocysteine deaminase activity
E4T63_RS01850	COG2188	Transcriptional regulator
E4T63_RS01860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4T63_RS01865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T63_RS01875	COG4176	ABC-type proline glycine betaine transport system permease component
E4T63_RS01880	COG4175	Glycine betaine
E4T63_RS01880	COG0517	IMP dehydrogenase activity
E4T63_RS01885	COG2986	histidine ammonia-lyase
E4T63_RS01890	COG2986	histidine ammonia-lyase
E4T63_RS01895	COG1228	amidohydrolase
E4T63_RS01905	COG0596	Alpha beta hydrolase
E4T63_RS01910	COG1490	D-aminoacyl-tRNA deacylase activity
E4T63_RS01915	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E4T63_RS01920	COG2943	transferase activity, transferring hexosyl groups
E4T63_RS01930	COG0765	amino acid transport
E4T63_RS01940	COG0840	transmembrane signaling receptor activity
E4T63_RS01955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T63_RS01960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4T63_RS01965	COG0140	phosphoribosyl-ATP diphosphatase activity
E4T63_RS01970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4T63_RS01975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4T63_RS01985	COG2226	methyltransferase
E4T63_RS02005	COG1309	transcriptional regulator
E4T63_RS02030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4T63_RS02035	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4T63_RS02045	COG0018	arginyl-trna synthetase
E4T63_RS02050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4T63_RS02055	COG0254	rRNA binding
E4T63_RS02065	COG0281	malic enzyme
E4T63_RS02100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4T63_RS02105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4T63_RS02120	COG0069	glutamate synthase activity
E4T63_RS02120	COG0070	glutamate synthase
E4T63_RS02120	COG0067	glutamate synthase
E4T63_RS02125	COG0493	'glutamate synthase
E4T63_RS02130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4T63_RS02140	COG2814	Major facilitator Superfamily
E4T63_RS02145	COG0583	DNA-binding transcription factor activity
E4T63_RS02165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T63_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS02180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T63_RS02225	COG2986	histidine ammonia-lyase
E4T63_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T63_RS02250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T63_RS02255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T63_RS02270	COG1192	Involved in chromosome partitioning
E4T63_RS02280	COG3118	belongs to the thioredoxin family
E4T63_RS02285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4T63_RS02290	COG3264	Mechanosensitive ion channel
E4T63_RS02290	COG1196	nuclear chromosome segregation
E4T63_RS02295	COG3263	regulation of cellular component size
E4T63_RS02315	COG0840	transmembrane signaling receptor activity
E4T63_RS02320	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS02325	COG0506	proline dehydrogenase activity
E4T63_RS02325	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4T63_RS02325	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4T63_RS02330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T63_RS02355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4T63_RS02360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T63_RS02370	COG3540	Alkaline phosphatase
E4T63_RS02385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4T63_RS02390	COG0859	PFAM glycosyl transferase family 9
E4T63_RS02395	COG0859	PFAM glycosyl transferase family 9
E4T63_RS02400	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS02435	COG2192	nodulation
E4T63_RS02440	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS02455	COG0297	glycogen (starch) synthase activity
E4T63_RS02460	COG1215	transferase activity, transferring glycosyl groups
E4T63_RS02475	COG1132	(ABC) transporter
E4T63_RS02485	COG0529	Catalyzes the synthesis of activated sulfate
E4T63_RS02495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4T63_RS02495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4T63_RS02505	COG0667	Aldo Keto reductase
E4T63_RS02520	COG0583	DNA-binding transcription factor activity
E4T63_RS02525	COG1519	Transferase
E4T63_RS02530	COG1538	Outer membrane efflux protein
E4T63_RS02535	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4T63_RS02555	COG0494	nUDIX hydrolase
E4T63_RS02565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4T63_RS02570	COG3150	esterase
E4T63_RS02585	COG3577	Aspartyl protease
E4T63_RS02620	COG0688	phosphatidylethanolamine metabolic process
E4T63_RS02640	COG1360	Flagellar Motor Protein
E4T63_RS02660	COG1162	GTPase activity
E4T63_RS02665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4T63_RS02670	COG2860	membrane
E4T63_RS02680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4T63_RS02680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4T63_RS02685	COG0802	atpase or kinase
E4T63_RS02690	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T63_RS02695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4T63_RS02700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4T63_RS02705	COG1923	regulation of RNA biosynthetic process
E4T63_RS02710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4T63_RS02715	COG0330	HflC and HflK could
E4T63_RS02720	COG0330	HflC and HflK could
E4T63_RS02725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E4T63_RS02730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4T63_RS02740	COG1178	ABC-type Fe3 transport system permease component
E4T63_RS02745	COG1840	ABC-type Fe3 transport system, periplasmic component
E4T63_RS02760	COG0557	exoribonuclease II activity
E4T63_RS02765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4T63_RS02775	COG0360	Binds together with S18 to 16S ribosomal RNA
E4T63_RS02780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4T63_RS02790	COG0359	binds to the 23S rRNA
E4T63_RS02795	COG0305	Participates in initiation and elongation during chromosome replication
E4T63_RS02800	COG1032	radical SAM domain protein
E4T63_RS02810	COG2308	Evidence 4 Homologs of previously reported genes of
E4T63_RS02810	COG2307	Protein conserved in bacteria
E4T63_RS02835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4T63_RS02840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4T63_RS02850	COG0583	DNA-binding transcription factor activity
E4T63_RS02855	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS02860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS02870	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4T63_RS02895	COG4221	oxidoreductase activity
E4T63_RS02920	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4T63_RS02925	COG0830	nickel cation binding
E4T63_RS02930	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E4T63_RS02935	COG1309	transcriptional regulator
E4T63_RS02945	COG2982	Protein involved in outer membrane biogenesis
E4T63_RS02955	COG0583	DNA-binding transcription factor activity
E4T63_RS02960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T63_RS02970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4T63_RS02975	COG0697	spore germination
E4T63_RS02995	COG0443	Heat shock 70 kDa protein
E4T63_RS03000	COG0484	heat shock protein binding
E4T63_RS03005	COG0789	Transcriptional regulator
E4T63_RS03015	COG0804	urea catabolic process
E4T63_RS03020	COG0832	Belongs to the urease beta subunit family
E4T63_RS03035	COG0831	urea catabolic process
E4T63_RS03040	COG0829	nickel cation binding
E4T63_RS03050	COG0411	ABC transporter
E4T63_RS03065	COG0683	leucine binding
E4T63_RS03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T63_RS03125	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4T63_RS03135	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4T63_RS03150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T63_RS03180	COG2095	MarC family integral membrane protein
E4T63_RS03200	COG0151	Belongs to the GarS family
E4T63_RS03205	COG0138	bifunctional purine biosynthesis protein purh
E4T63_RS03215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T63_RS03225	COG2264	protein methyltransferase activity
E4T63_RS03265	COG0023	Translation Initiation Factor
E4T63_RS03270	COG1166	arginine decarboxylase activity
E4T63_RS03285	COG0657	acetylesterase activity
E4T63_RS03290	COG0534	Mate efflux family protein
E4T63_RS03305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4T63_RS03365	COG4964	Belongs to the GSP D family
E4T63_RS03415	COG2030	dehydratase
E4T63_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS03425	COG0183	Belongs to the thiolase family
E4T63_RS03450	COG2217	Heavy metal translocating P-type atpase
E4T63_RS03470	COG2814	Major facilitator Superfamily
E4T63_RS03475	COG0604	alcohol dehydrogenase
E4T63_RS03485	COG0583	DNA-binding transcription factor activity
E4T63_RS03495	COG0477	Major facilitator Superfamily
E4T63_RS03505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4T63_RS03525	COG0387	Pfam Sodium calcium exchanger
E4T63_RS03550	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4T63_RS03555	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4T63_RS03560	COG3845	ABC transporter
E4T63_RS03565	COG1739	Uncharacterized protein family UPF0029
E4T63_RS03570	COG1309	transcriptional regulator
E4T63_RS03575	COG2233	PERMEase
E4T63_RS03615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4T63_RS03620	COG1074	ATP-dependent DNA helicase activity
E4T63_RS03625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4T63_RS03635	COG2199	diguanylate cyclase activity
E4T63_RS03670	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T63_RS03690	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T63_RS03695	COG0583	DNA-binding transcription factor activity
E4T63_RS03705	COG2610	gluconate transmembrane transporter activity
E4T63_RS03715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E4T63_RS03740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4T63_RS03745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4T63_RS03770	COG1487	ribonuclease activity
E4T63_RS03775	COG0840	transmembrane signaling receptor activity
E4T63_RS03785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T63_RS03850	COG0247	lactate metabolic process
E4T63_RS03855	COG1620	l-lactate permease
E4T63_RS03860	COG2186	Transcriptional regulator
E4T63_RS03865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4T63_RS03870	COG0733	neurotransmitter:sodium symporter activity
E4T63_RS03880	COG2914	Belongs to the UPF0125 (RnfH) family
E4T63_RS03885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T63_RS03890	COG0735	belongs to the Fur family
E4T63_RS03895	COG0497	DNA recombination
E4T63_RS03900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4T63_RS03905	COG0443	Heat shock 70 kDa protein
E4T63_RS03910	COG0484	heat shock protein binding
E4T63_RS03915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4T63_RS03920	COG0505	Belongs to the CarA family
E4T63_RS03925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4T63_RS03930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T63_RS03945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4T63_RS03950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4T63_RS03955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4T63_RS03960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4T63_RS03965	COG0149	triose-phosphate isomerase activity
E4T63_RS03970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4T63_RS03985	COG0779	Required for maturation of 30S ribosomal subunits
E4T63_RS03990	COG0195	Participates in both transcription termination and antitermination
E4T63_RS03995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4T63_RS04000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4T63_RS04005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4T63_RS04010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4T63_RS04015	COG1185	polyribonucleotide nucleotidyltransferase activity
E4T63_RS04060	COG0084	hydrolase, TatD family'
E4T63_RS04065	COG1609	Transcriptional regulator
E4T63_RS04070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T63_RS04070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T63_RS04075	COG1105	Belongs to the carbohydrate kinase PfkB family
E4T63_RS04080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T63_RS04080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4T63_RS04080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4T63_RS04090	COG2852	Protein conserved in bacteria
E4T63_RS04100	COG4774	siderophore transport
E4T63_RS04105	COG3128	pkhd-type hydroxylase
E4T63_RS04125	COG0019	diaminopimelate decarboxylase activity
E4T63_RS04150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4T63_RS04165	COG4608	Belongs to the ABC transporter superfamily
E4T63_RS04170	COG0444	Belongs to the ABC transporter superfamily
E4T63_RS04175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4T63_RS04180	COG0601	transmembrane transport
E4T63_RS04185	COG0747	negative chemotaxis
E4T63_RS04195	COG0747	negative chemotaxis
E4T63_RS04200	COG0747	negative chemotaxis
E4T63_RS04205	COG0747	negative chemotaxis
E4T63_RS04225	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E4T63_RS04235	COG4178	(ABC) transporter
E4T63_RS04260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T63_RS04270	COG2271	Major facilitator Superfamily
E4T63_RS04275	COG2721	sulfolactate sulfo-lyase activity
E4T63_RS04285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T63_RS04295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4T63_RS04300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4T63_RS04305	COG0154	amidase activity
E4T63_RS04310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4T63_RS04315	COG1077	Cell shape determining protein MreB Mrl
E4T63_RS04320	COG1792	Involved in formation and maintenance of cell shape
E4T63_RS04330	COG0424	maF-like protein
E4T63_RS04335	COG1530	ribonuclease E activity
E4T63_RS04345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T63_RS04350	COG0312	modulator of DNA gyrase
E4T63_RS04355	COG3028	Belongs to the UPF0307 family
E4T63_RS04360	COG0312	modulator of DNA gyrase
E4T63_RS04395	COG1660	Displays ATPase and GTPase activities
E4T63_RS04405	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4T63_RS04410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4T63_RS04415	COG1137	ATPase activity
E4T63_RS04420	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4T63_RS04430	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4T63_RS04440	COG1127	ABC transporter
E4T63_RS04445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4T63_RS04450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4T63_RS04465	COG5007	Belongs to the BolA IbaG family
E4T63_RS04470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4T63_RS04475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4T63_RS04480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4T63_RS04485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4T63_RS04500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T63_RS04510	COG0175	sulfate reduction
E4T63_RS04520	COG0204	Acyl-transferase
E4T63_RS04525	COG0857	belongs to the CobB CobQ family
E4T63_RS04525	COG0280	phosphate acetyltransferase
E4T63_RS04540	COG0386	Belongs to the glutathione peroxidase family
E4T63_RS04560	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
E4T63_RS04570	COG0492	ferredoxin-NADP+ reductase activity
E4T63_RS04585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4T63_RS04590	COG0302	gtp cyclohydrolase
E4T63_RS04605	COG0789	Transcriptional regulator
E4T63_RS04615	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T63_RS04625	COG0583	DNA-binding transcription factor activity
E4T63_RS04630	COG1380	Effector of murein hydrolase LrgA
E4T63_RS04635	COG1346	cytolysis
E4T63_RS04645	COG0596	Alpha beta hydrolase
E4T63_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS04665	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4T63_RS04670	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4T63_RS04690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4T63_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS04715	COG3916	Acyl-homoserine-lactone synthase
E4T63_RS04720	COG2197	response regulator
E4T63_RS04735	COG0814	amino acid
E4T63_RS04740	COG1760	l-serine dehydratase
E4T63_RS04745	COG0583	DNA-binding transcription factor activity
E4T63_RS04755	COG4772	TonB-dependent receptor
E4T63_RS04760	COG3712	iron ion homeostasis
E4T63_RS04765	COG1595	DNA-templated transcription, initiation
E4T63_RS04795	COG4774	siderophore transport
E4T63_RS04815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T63_RS04820	COG3328	transposase activity
E4T63_RS04830	COG0583	DNA-binding transcription factor activity
E4T63_RS04850	COG1566	PFAM secretion protein HlyD family protein
E4T63_RS04860	COG0477	Major facilitator Superfamily
E4T63_RS04875	COG0300	oxidoreductase activity
E4T63_RS04890	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E4T63_RS04890	COG0662	Cupin 2, conserved barrel domain protein
E4T63_RS04905	COG1696	Membrane protein involved in D-alanine export
E4T63_RS04925	COG3420	alginic acid biosynthetic process
E4T63_RS04935	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4T63_RS04945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS04950	COG1215	transferase activity, transferring glycosyl groups
E4T63_RS04960	COG3022	response to hydroperoxide
E4T63_RS04970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4T63_RS04975	COG0315	cyclic pyranopterin monophosphate synthase activity
E4T63_RS04980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4T63_RS05020	COG0513	Belongs to the DEAD box helicase family
E4T63_RS05025	COG0400	carboxylic ester hydrolase activity
E4T63_RS05030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS05035	COG4597	amino acid ABC transporter
E4T63_RS05040	COG0765	amino acid transport
E4T63_RS05045	COG1126	abc transporter atp-binding protein
E4T63_RS05050	COG4935	Belongs to the peptidase S8 family
E4T63_RS05050	COG1404	Belongs to the peptidase S8 family
E4T63_RS05055	COG2186	Transcriptional regulator
E4T63_RS05060	COG2807	transmembrane transport
E4T63_RS05070	COG2827	Endonuclease containing a URI domain
E4T63_RS05085	COG3081	Nucleoid-associated protein
E4T63_RS05095	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4T63_RS05100	COG0525	valine-tRNA ligase activity
E4T63_RS05115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4T63_RS05120	COG0795	lipopolysaccharide-transporting ATPase activity
E4T63_RS05125	COG0795	lipopolysaccharide-transporting ATPase activity
E4T63_RS05130	COG0481	GTPase activity
E4T63_RS05135	COG0681	Belongs to the peptidase S26 family
E4T63_RS05140	COG0571	ribonuclease III activity
E4T63_RS05145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4T63_RS05155	COG1381	Involved in DNA repair and RecF pathway recombination
E4T63_RS05160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4T63_RS05165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4T63_RS05170	COG0047	phosphoribosylformylglycinamidine synthase activity
E4T63_RS05170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4T63_RS05175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4T63_RS05190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4T63_RS05190	COG2190	(PTS) system
E4T63_RS05190	COG1263	PTS System
E4T63_RS05195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4T63_RS05195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4T63_RS05200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4T63_RS05205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4T63_RS05210	COG2188	Transcriptional regulator
E4T63_RS05225	COG0494	nUDIX hydrolase
E4T63_RS05245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4T63_RS05250	COG0477	Major facilitator Superfamily
E4T63_RS05255	COG4536	flavin adenine dinucleotide binding
E4T63_RS05265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4T63_RS05270	COG0228	four-way junction DNA binding
E4T63_RS05275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4T63_RS05280	COG0336	Belongs to the RNA methyltransferase TrmD family
E4T63_RS05285	COG0335	large ribosomal subunit rRNA binding
E4T63_RS05290	COG1607	acyl-coa hydrolase
E4T63_RS05300	COG4974	Belongs to the 'phage' integrase family
E4T63_RS05320	COG2205	protein histidine kinase activity
E4T63_RS05320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS05340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4T63_RS05355	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS05360	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E4T63_RS05390	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS05395	COG1177	transmembrane transport
E4T63_RS05400	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T63_RS05405	COG3842	ATPase activity
E4T63_RS05410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4T63_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS05420	COG0583	DNA-binding transcription factor activity
E4T63_RS05460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4T63_RS05460	COG0457	Tetratricopeptide repeat
E4T63_RS05475	COG2201	protein-glutamate methylesterase activity
E4T63_RS05480	COG3706	GGDEF domain
E4T63_RS05480	COG5001	Diguanylate cyclase
E4T63_RS05480	COG2203	Gaf domain
E4T63_RS05480	COG4251	negative regulation of phosphorylation
E4T63_RS05490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4T63_RS05515	COG1073	alpha beta
E4T63_RS05540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4T63_RS05545	COG0563	adenylate kinase activity
E4T63_RS05550	COG1214	PFAM Peptidase M22, glycoprotease
E4T63_RS05560	COG1801	Protein of unknown function DUF72
E4T63_RS05580	COG0742	ribosomal rna small subunit methyltransferase
E4T63_RS05590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS05620	COG2937	Belongs to the GPAT DAPAT family
E4T63_RS05635	COG2226	methyltransferase
E4T63_RS05640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4T63_RS05645	COG1215	transferase activity, transferring glycosyl groups
E4T63_RS05650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4T63_RS05660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4T63_RS05665	COG2171	N-acyltransferase activity
E4T63_RS05670	COG1393	Belongs to the ArsC family
E4T63_RS05675	COG0025	NhaP-type Na H and K H
E4T63_RS05690	COG0436	Aminotransferase
E4T63_RS05695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4T63_RS05700	COG0024	Methionine aminopeptidase
E4T63_RS05705	COG0052	Belongs to the universal ribosomal protein uS2 family
E4T63_RS05710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4T63_RS05715	COG0528	UMP kinase activity
E4T63_RS05720	COG0233	cytoplasmic translational termination
E4T63_RS05725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4T63_RS05735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4T63_RS05755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T63_RS05760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T63_RS05765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T63_RS05770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T63_RS05775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4T63_RS05780	COG0587	DNA-directed DNA polymerase activity
E4T63_RS05785	COG0825	malonyl-CoA metabolic process
E4T63_RS05790	COG0037	tRNA processing
E4T63_RS05795	COG0504	CTP synthase activity
E4T63_RS05800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4T63_RS05805	COG0148	phosphopyruvate hydratase activity
E4T63_RS05815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4T63_RS05825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4T63_RS05830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4T63_RS05835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4T63_RS05840	COG0585	pseudouridine synthase activity
E4T63_RS05845	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4T63_RS05850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4T63_RS05870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4T63_RS05975	COG4386	tail sheath protein
E4T63_RS06010	COG4381	Mu-like prophage protein gp46
E4T63_RS06065	COG3179	chitinase
E4T63_RS06075	COG1546	Belongs to the CinA family
E4T63_RS06080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4T63_RS06085	COG2137	regulation of response to DNA damage stimulus
E4T63_RS06105	COG3148	PFAM DTW domain containing protein
E4T63_RS06120	COG0583	DNA-binding transcription factor activity
E4T63_RS06140	COG4807	Protein conserved in bacteria
E4T63_RS06160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4T63_RS06165	COG3158	transport of potassium into the cell
E4T63_RS06200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4T63_RS06210	COG0442	prolyl-tRNA aminoacylation
E4T63_RS06230	COG1278	Cold shock
E4T63_RS06235	COG0717	Belongs to the dCTP deaminase family
E4T63_RS06250	COG1201	RNA secondary structure unwinding
E4T63_RS06255	COG4598	ABC transporter
E4T63_RS06280	COG1793	dna ligase
E4T63_RS06290	COG2366	antibiotic biosynthetic process
E4T63_RS06300	COG0653	protein targeting
E4T63_RS06310	COG3012	SEC-C Motif Domain Protein
E4T63_RS06345	COG1199	ATP-dependent helicase activity
E4T63_RS06355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4T63_RS06360	COG2885	chlorophyll binding
E4T63_RS06365	COG0259	pyridoxamine-phosphate oxidase activity
E4T63_RS06395	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E4T63_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS06410	COG0583	DNA-binding transcription factor activity
E4T63_RS06425	COG3220	belongs to the UPF0276 family
E4T63_RS06470	COG2084	Dehydrogenase
E4T63_RS06480	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4T63_RS06485	COG2271	Major facilitator Superfamily
E4T63_RS06490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T63_RS06500	COG0306	phosphate transporter
E4T63_RS06510	COG1414	Transcriptional regulator
E4T63_RS06515	COG2814	Major facilitator Superfamily
E4T63_RS06520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4T63_RS06525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4T63_RS06530	COG0183	Belongs to the thiolase family
E4T63_RS06535	COG3485	protocatechuate 3,4-dioxygenase
E4T63_RS06540	COG3485	protocatechuate 3,4-dioxygenase
E4T63_RS06545	COG0477	Major facilitator Superfamily
E4T63_RS06555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T63_RS06560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T63_RS06595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS06600	COG1309	transcriptional regulator
E4T63_RS06610	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS06615	COG2814	Major facilitator Superfamily
E4T63_RS06665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T63_RS06675	COG1704	LemA family
E4T63_RS06680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4T63_RS06700	COG0697	spore germination
E4T63_RS06705	COG0693	protein deglycase activity
E4T63_RS06730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T63_RS06735	COG0235	Class ii aldolase
E4T63_RS06740	COG1396	sequence-specific DNA binding
E4T63_RS06750	COG1454	alcohol dehydrogenase
E4T63_RS06755	COG2814	Major facilitator Superfamily
E4T63_RS06815	COG4106	trans-aconitate 2-methyltransferase activity
E4T63_RS06835	COG2267	carboxylic ester hydrolase activity
E4T63_RS06865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4T63_RS06915	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4T63_RS06945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4T63_RS06950	COG4783	chaperone-mediated protein folding
E4T63_RS06955	COG0425	Belongs to the sulfur carrier protein TusA family
E4T63_RS06960	COG0628	permease
E4T63_RS06965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4T63_RS06980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T63_RS06985	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4T63_RS06990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4T63_RS06995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4T63_RS07035	COG0463	Glycosyl transferase, family 2
E4T63_RS07075	COG2807	transmembrane transport
E4T63_RS07085	COG3100	YcgL domain-containing protein
E4T63_RS07100	COG2983	Belongs to the UPF0260 family
E4T63_RS07140	COG1770	oligopeptidase
E4T63_RS07150	COG0121	glutamine amidotransferase
E4T63_RS07160	COG0583	DNA-binding transcription factor activity
E4T63_RS07165	COG2814	Major facilitator Superfamily
E4T63_RS07170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4T63_RS07175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4T63_RS07180	COG1984	allophanate hydrolase subunit 2
E4T63_RS07190	COG0542	response to heat
E4T63_RS07210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4T63_RS07240	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4T63_RS07245	COG1643	Atp-dependent helicase
E4T63_RS07255	COG1595	DNA-templated transcription, initiation
E4T63_RS07265	COG2188	Transcriptional regulator
E4T63_RS07275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4T63_RS07280	COG1132	(ABC) transporter
E4T63_RS07310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T63_RS07320	COG0668	transmembrane transport
E4T63_RS07325	COG0513	Belongs to the DEAD box helicase family
E4T63_RS07405	COG2996	Protein conserved in bacteria
E4T63_RS07415	COG0697	spore germination
E4T63_RS07425	COG0583	DNA-binding transcription factor activity
E4T63_RS07435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T63_RS07440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T63_RS07470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS07525	COG2832	Protein of unknown function (DUF454)
E4T63_RS07550	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4T63_RS07590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4T63_RS07595	COG0778	Nitroreductase
E4T63_RS07600	COG0642	Histidine kinase
E4T63_RS07610	COG0745	RESPONSE REGULATOR receiver
E4T63_RS07620	COG2350	Protein conserved in bacteria
E4T63_RS07625	COG2917	probably involved in intracellular septation
E4T63_RS07635	COG0009	L-threonylcarbamoyladenylate synthase
E4T63_RS07645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4T63_RS07665	COG1113	amino acid transport
E4T63_RS07685	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4T63_RS07715	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4T63_RS07730	COG4787	bacterial-type flagellum-dependent cell motility
E4T63_RS07740	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4T63_RS07745	COG1706	bacterial-type flagellum-dependent cell motility
E4T63_RS07755	COG1256	bacterial-type flagellum assembly
E4T63_RS07780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4T63_RS07790	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E4T63_RS07815	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS07815	COG1216	Glycosyl transferase, family 2
E4T63_RS07820	COG1086	Polysaccharide biosynthesis protein
E4T63_RS07825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T63_RS07835	COG1083	cytidylyl-transferase
E4T63_RS07845	COG2089	acid synthase
E4T63_RS07875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4T63_RS07905	COG1677	Flagellar hook-basal body complex protein FliE
E4T63_RS07950	COG0745	RESPONSE REGULATOR receiver
E4T63_RS07965	COG1580	Controls the rotational direction of flagella during chemotaxis
E4T63_RS08050	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4T63_RS08055	COG0643	Histidine kinase
E4T63_RS08055	COG2198	Histidine kinase
E4T63_RS08055	COG0784	Response regulator, receiver
E4T63_RS08060	COG2201	protein-glutamate methylesterase activity
E4T63_RS08065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4T63_RS08075	COG1192	Involved in chromosome partitioning
E4T63_RS08085	COG0835	chemotaxis
E4T63_RS08110	COG4133	protoheme IX ABC transporter activity
E4T63_RS08130	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4T63_RS08135	COG1138	Cytochrome C-type biogenesis protein
E4T63_RS08145	COG3088	subunit of a heme lyase
E4T63_RS08160	COG0583	DNA-binding transcription factor activity
E4T63_RS08170	COG1598	PFAM Uncharacterised protein family UPF0150
E4T63_RS08175	COG2814	Major facilitator Superfamily
E4T63_RS08200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T63_RS08210	COG0469	pyruvate kinase activity
E4T63_RS08220	COG2084	Dehydrogenase
E4T63_RS08225	COG3622	Belongs to the hyi family
E4T63_RS08230	COG3960	tartronate-semialdehyde synthase activity
E4T63_RS08245	COG1309	transcriptional regulator
E4T63_RS08250	COG2354	Protein conserved in bacteria
E4T63_RS08255	COG2853	Lipoprotein
E4T63_RS08280	COG2113	Glycine betaine
E4T63_RS08290	COG3162	membrane
E4T63_RS08295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4T63_RS08305	COG2009	succinate dehydrogenase
E4T63_RS08310	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4T63_RS08315	COG1053	succinate dehydrogenase
E4T63_RS08320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4T63_RS08335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T63_RS08340	COG0045	succinate-CoA ligase (ADP-forming) activity
E4T63_RS08380	COG0326	Molecular chaperone. Has ATPase activity
E4T63_RS08390	COG1741	Belongs to the pirin family
E4T63_RS08415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4T63_RS08420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4T63_RS08430	COG0628	permease
E4T63_RS08435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4T63_RS08440	COG0791	NLP P60 protein
E4T63_RS08445	COG0791	NLP P60 protein
E4T63_RS08465	COG1797	cobyrinic acid a,c-diamide synthase activity
E4T63_RS08470	COG0778	Nitroreductase
E4T63_RS08485	COG1492	cobalamin metabolic process
E4T63_RS08495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4T63_RS08500	COG0406	alpha-ribazole phosphatase activity
E4T63_RS08505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4T63_RS08555	COG2205	protein histidine kinase activity
E4T63_RS08585	COG2076	Multidrug Resistance protein
E4T63_RS08590	COG0385	Bile acid
E4T63_RS08595	COG2974	May be involved in recombination
E4T63_RS08625	COG2010	Cytochrome c
E4T63_RS08630	COG0545	Peptidyl-prolyl cis-trans isomerase
E4T63_RS08655	COG3209	COG3209 Rhs family protein
E4T63_RS08675	COG2200	EAL domain
E4T63_RS08685	COG4221	oxidoreductase activity
E4T63_RS08685	COG3321	synthase
E4T63_RS08685	COG0604	alcohol dehydrogenase
E4T63_RS08685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T63_RS08695	COG3842	ATPase activity
E4T63_RS08705	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T63_RS08725	COG1473	amidohydrolase
E4T63_RS08730	COG0668	transmembrane transport
E4T63_RS08735	COG1362	aminopeptidase activity
E4T63_RS08745	COG0564	pseudouridine synthase activity
E4T63_RS08750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4T63_RS08755	COG2894	cell division
E4T63_RS08760	COG0850	regulation of cytokinetic process
E4T63_RS08765	COG1560	Kdo2-lipid A biosynthetic process
E4T63_RS08785	COG2233	PERMEase
E4T63_RS08795	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4T63_RS08800	COG4266	Belongs to the allantoicase family
E4T63_RS08830	COG2252	PERMEase
E4T63_RS08840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS08850	COG0302	gtp cyclohydrolase
E4T63_RS08855	COG2840	Smr protein MutS2
E4T63_RS08880	COG1073	alpha beta
E4T63_RS08885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4T63_RS08895	COG0235	Class ii aldolase
E4T63_RS08900	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4T63_RS08905	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
E4T63_RS08915	COG0318	PFAM AMP-dependent synthetase and ligase
E4T63_RS08940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4T63_RS08955	COG2308	Evidence 4 Homologs of previously reported genes of
E4T63_RS08965	COG1305	Transglutaminase-like
E4T63_RS08975	COG0183	Belongs to the thiolase family
E4T63_RS08980	COG1024	Enoyl-CoA hydratase
E4T63_RS08980	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T63_RS08985	COG0519	Catalyzes the synthesis of GMP from XMP
E4T63_RS08985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4T63_RS08990	COG0598	Magnesium transport protein CorA
E4T63_RS09010	COG0393	Putative heavy-metal-binding
E4T63_RS09040	COG3209	COG3209 Rhs family protein
E4T63_RS09045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T63_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS09055	COG0583	DNA-binding transcription factor activity
E4T63_RS09065	COG1953	Uracil, thiamine, allantoin
E4T63_RS09075	COG0560	Phosphoserine phosphatase
E4T63_RS09085	COG2801	Transposase and inactivated derivatives
E4T63_RS09085	COG3415	Transposase
E4T63_RS09090	COG0189	ligase activity
E4T63_RS09100	COG0189	ligase activity
E4T63_RS09100	COG4067	protein conserved in archaea
E4T63_RS09105	COG1802	Transcriptional regulator
E4T63_RS09115	COG0372	Belongs to the citrate synthase family
E4T63_RS09135	COG2079	MmgE PrpD family protein
E4T63_RS09140	COG1116	anion transmembrane transporter activity
E4T63_RS09150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4T63_RS09160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS09165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4T63_RS09180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4T63_RS09195	COG0668	transmembrane transport
E4T63_RS09210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4T63_RS09215	COG0243	molybdopterin cofactor binding
E4T63_RS09220	COG2146	nitrite reductase [NAD(P)H] activity
E4T63_RS09225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T63_RS09235	COG2223	nitrite transmembrane transporter activity
E4T63_RS09240	COG3707	response regulator
E4T63_RS09245	COG1116	anion transmembrane transporter activity
E4T63_RS09245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T63_RS09250	COG0167	dihydroorotate dehydrogenase activity
E4T63_RS09255	COG3130	regulation of translation
E4T63_RS09260	COG0116	Belongs to the methyltransferase superfamily
E4T63_RS09260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T63_RS09275	COG2027	D-alanyl-D-alanine carboxypeptidase
E4T63_RS09280	COG3171	Protein conserved in bacteria
E4T63_RS09285	COG3135	benzoate transporter
E4T63_RS09290	COG1802	Transcriptional regulator
E4T63_RS09295	COG0402	S-adenosylhomocysteine deaminase activity
E4T63_RS09325	COG3115	cell septum assembly
E4T63_RS09330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4T63_RS09355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4T63_RS09360	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4T63_RS09365	COG2130	NADP-dependent
E4T63_RS09370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4T63_RS09375	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS09380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4T63_RS09385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T63_RS09410	COG2217	Heavy metal translocating P-type atpase
E4T63_RS09420	COG0348	domain, Protein
E4T63_RS09445	COG2010	Cytochrome c
E4T63_RS09460	COG3278	Belongs to the heme-copper respiratory oxidase family
E4T63_RS09465	COG2010	Cytochrome c
E4T63_RS09480	COG3278	Belongs to the heme-copper respiratory oxidase family
E4T63_RS09500	COG0840	transmembrane signaling receptor activity
E4T63_RS09515	COG4977	sequence-specific DNA binding
E4T63_RS09520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4T63_RS09530	COG3387	PFAM Glycoside hydrolase 15-related
E4T63_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS09540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4T63_RS09570	COG0657	acetylesterase activity
E4T63_RS09580	COG4774	siderophore transport
E4T63_RS09615	COG1136	(ABC) transporter
E4T63_RS09615	COG0577	efflux transmembrane transporter activity
E4T63_RS09620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS09635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4T63_RS09655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS09655	COG2205	protein histidine kinase activity
E4T63_RS09660	COG0656	L-ascorbic acid biosynthetic process
E4T63_RS09675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T63_RS09700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4T63_RS09710	COG1595	DNA-templated transcription, initiation
E4T63_RS09720	COG4772	TonB-dependent receptor
E4T63_RS09730	COG2223	nitrite transmembrane transporter activity
E4T63_RS09740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4T63_RS09745	COG0402	S-adenosylhomocysteine deaminase activity
E4T63_RS09750	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T63_RS09760	COG0720	synthase
E4T63_RS09795	COG0840	transmembrane signaling receptor activity
E4T63_RS09800	COG2056	Na+-H+ antiporter family
E4T63_RS09810	COG0583	DNA-binding transcription factor activity
E4T63_RS09850	COG1063	alcohol dehydrogenase
E4T63_RS09875	COG0709	Synthesizes selenophosphate from selenide and ATP
E4T63_RS09880	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4T63_RS09890	COG0625	glutathione transferase activity
E4T63_RS09895	COG0113	porphobilinogen synthase activity
E4T63_RS09930	COG4172	Belongs to the ABC transporter superfamily
E4T63_RS09935	COG4239	(ABC) transporter, permease
E4T63_RS09940	COG4174	ABC transporter (Permease)
E4T63_RS09945	COG4166	transmembrane transport
E4T63_RS09975	COG0517	IMP dehydrogenase activity
E4T63_RS09980	COG0417	DNA replication proofreading
E4T63_RS09990	COG0656	L-ascorbic acid biosynthetic process
E4T63_RS10010	COG0730	response to heat
E4T63_RS10070	COG2186	Transcriptional regulator
E4T63_RS10080	COG0697	spore germination
E4T63_RS10085	COG0583	DNA-binding transcription factor activity
E4T63_RS10095	COG0826	peptidase U32
E4T63_RS10100	COG1335	isochorismatase
E4T63_RS10105	COG0628	permease
E4T63_RS10125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4T63_RS10135	COG3132	Protein of unknown function, DUF480
E4T63_RS10145	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4T63_RS10155	COG0583	DNA-binding transcription factor activity
E4T63_RS10165	COG1253	flavin adenine dinucleotide binding
E4T63_RS10185	COG1686	Belongs to the peptidase S11 family
E4T63_RS10205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4T63_RS10230	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4T63_RS10235	COG0740	serine-type endopeptidase activity
E4T63_RS10240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4T63_RS10245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4T63_RS10250	COG0776	regulation of translation
E4T63_RS10255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T63_RS10260	COG2814	Major facilitator Superfamily
E4T63_RS10285	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T63_RS10285	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS10300	COG3038	cytochrome b561
E4T63_RS10305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T63_RS10315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4T63_RS10320	COG0583	DNA-binding transcription factor activity
E4T63_RS10325	COG0583	DNA-binding transcription factor activity
E4T63_RS10330	COG2271	Major facilitator Superfamily
E4T63_RS10335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS10345	COG0217	transcriptional regulatory protein
E4T63_RS10360	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4T63_RS10420	COG3038	cytochrome b561
E4T63_RS10425	COG2814	Major facilitator Superfamily
E4T63_RS10430	COG2866	Carboxypeptidase
E4T63_RS10440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4T63_RS10450	COG1024	Enoyl-CoA hydratase
E4T63_RS10455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4T63_RS10460	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS10465	COG0318	PFAM AMP-dependent synthetase and ligase
E4T63_RS10480	COG0789	Transcriptional regulator
E4T63_RS10490	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS10500	COG0708	Exodeoxyribonuclease III
E4T63_RS10510	COG0729	surface antigen
E4T63_RS10525	COG1846	Transcriptional regulator
E4T63_RS10535	COG1566	PFAM secretion protein HlyD family protein
E4T63_RS10540	COG2814	Major facilitator Superfamily
E4T63_RS10545	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4T63_RS10555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4T63_RS10560	COG0215	cysteine-tRNA ligase activity
E4T63_RS10565	COG1968	undecaprenyl-diphosphatase activity
E4T63_RS10570	COG3284	Transcriptional regulator
E4T63_RS10575	COG3842	ATPase activity
E4T63_RS10580	COG3842	ATPase activity
E4T63_RS10590	COG0395	ABC-type sugar transport system, permease component
E4T63_RS10665	COG2944	sequence-specific DNA binding
E4T63_RS10670	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E4T63_RS10680	COG1007	ATP synthesis coupled electron transport
E4T63_RS10695	COG0713	ATP synthesis coupled electron transport
E4T63_RS10705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T63_RS10710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4T63_RS10715	COG1034	ATP synthesis coupled electron transport
E4T63_RS10730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T63_RS10730	COG0649	NAD binding
E4T63_RS10735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T63_RS10740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4T63_RS10755	COG2153	protein acetylation
E4T63_RS10760	COG2850	peptidyl-arginine hydroxylation
E4T63_RS10770	COG2915	High frequency lysogenization protein hflD homolog
E4T63_RS10775	COG0482	sulfurtransferase activity
E4T63_RS10800	COG1278	Cold shock
E4T63_RS10805	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4T63_RS10810	COG0542	response to heat
E4T63_RS10815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4T63_RS10820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4T63_RS10825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4T63_RS10830	COG0492	ferredoxin-NADP+ reductase activity
E4T63_RS10835	COG1674	ftsk spoiiie
E4T63_RS10840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4T63_RS10845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4T63_RS10850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4T63_RS10855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4T63_RS10860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4T63_RS10860	COG1648	precorrin-2 dehydrogenase activity
E4T63_RS10865	COG0435	Glutathione S-transferase
E4T63_RS10875	COG2920	part of a sulfur-relay system
E4T63_RS10910	COG0454	-acetyltransferase
E4T63_RS10925	COG3469	chitinase activity
E4T63_RS10930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS10945	COG0436	Aminotransferase
E4T63_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS10985	COG0494	nUDIX hydrolase
E4T63_RS11030	COG0659	secondary active sulfate transmembrane transporter activity
E4T63_RS11035	COG0697	spore germination
E4T63_RS11040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS11045	COG3474	cytochrome
E4T63_RS11065	COG0534	Mate efflux family protein
E4T63_RS11095	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4T63_RS11140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T63_RS11145	COG2201	protein-glutamate methylesterase activity
E4T63_RS11150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4T63_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS11185	COG3383	formate dehydrogenase (NAD+) activity
E4T63_RS11190	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T63_RS11195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS11210	COG0583	DNA-binding transcription factor activity
E4T63_RS11260	COG1230	cation diffusion facilitator family transporter
E4T63_RS11290	COG0583	DNA-binding transcription factor activity
E4T63_RS11295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4T63_RS11300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T63_RS11310	COG0022	dehydrogenase e1 component
E4T63_RS11315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4T63_RS11320	COG1522	sequence-specific DNA binding
E4T63_RS11330	COG0640	Transcriptional regulator
E4T63_RS11340	COG0730	response to heat
E4T63_RS11365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T63_RS11390	COG1276	copper resistance
E4T63_RS11400	COG1309	transcriptional regulator
E4T63_RS11420	COG1953	Uracil, thiamine, allantoin
E4T63_RS11445	COG2233	PERMEase
E4T63_RS11455	COG0523	cobalamin synthesis protein
E4T63_RS11465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4T63_RS11480	COG3618	amidohydrolase
E4T63_RS11500	COG0583	DNA-binding transcription factor activity
E4T63_RS11520	COG3328	transposase activity
E4T63_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS11540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T63_RS11560	COG0814	amino acid
E4T63_RS11585	COG0589	response to stress
E4T63_RS11595	COG0745	RESPONSE REGULATOR receiver
E4T63_RS11600	COG2205	protein histidine kinase activity
E4T63_RS11605	COG3791	Glutathione-dependent formaldehyde-activating
E4T63_RS11610	COG0583	DNA-binding transcription factor activity
E4T63_RS11635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T63_RS11635	COG2169	Transcriptional regulator
E4T63_RS11640	COG0346	lactoylglutathione lyase activity
E4T63_RS11645	COG1280	lysine exporter protein (LysE YggA)
E4T63_RS11655	COG4251	negative regulation of phosphorylation
E4T63_RS11685	COG2226	methyltransferase
E4T63_RS11715	COG2199	diguanylate cyclase activity
E4T63_RS11715	COG2203	Gaf domain
E4T63_RS11735	COG4172	Belongs to the ABC transporter superfamily
E4T63_RS11740	COG4239	(ABC) transporter, permease
E4T63_RS11745	COG4174	ABC transporter (Permease)
E4T63_RS11750	COG4166	transmembrane transport
E4T63_RS11755	COG4166	transmembrane transport
E4T63_RS11760	COG1388	LysM domain
E4T63_RS11760	COG0741	lytic transglycosylase activity
E4T63_RS11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T63_RS11775	COG0328	RNA-DNA hybrid ribonuclease activity
E4T63_RS11780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T63_RS11805	COG0431	NADPH-dependent FMN reductase
E4T63_RS11810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4T63_RS11820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4T63_RS11825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T63_RS11830	COG0705	Rhomboid family
E4T63_RS11835	COG3139	Protein of unknown function (DUF1315)
E4T63_RS11845	COG0308	aminopeptidase N
E4T63_RS11850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4T63_RS11880	COG1999	signal sequence binding
E4T63_RS11910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS11915	COG0577	efflux transmembrane transporter activity
E4T63_RS11915	COG1136	(ABC) transporter
E4T63_RS11945	COG1063	alcohol dehydrogenase
E4T63_RS11960	COG0589	response to stress
E4T63_RS11970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4T63_RS11980	COG1335	isochorismatase
E4T63_RS12000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4T63_RS12005	COG2011	ABC-type metal ion transport system permease component
E4T63_RS12010	COG1129	ABC transporter
E4T63_RS12015	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T63_RS12025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4T63_RS12050	COG0531	amino acid
E4T63_RS12065	COG4977	sequence-specific DNA binding
E4T63_RS12065	COG1917	Cupin 2, conserved barrel domain protein
E4T63_RS12080	COG1116	anion transmembrane transporter activity
E4T63_RS12080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T63_RS12085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T63_RS12090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS12110	COG1511	domain protein
E4T63_RS12110	COG3264	Mechanosensitive ion channel
E4T63_RS12130	COG0642	Histidine kinase
E4T63_RS12155	COG0456	acetyltransferase
E4T63_RS12185	COG2384	SAM-dependent methyltransferase
E4T63_RS12195	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS12200	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E4T63_RS12225	COG0789	Transcriptional regulator
E4T63_RS12255	COG3011	Protein conserved in bacteria
E4T63_RS12310	COG0477	Major facilitator Superfamily
E4T63_RS12315	COG1944	ATP diphosphatase activity
E4T63_RS12340	COG2365	Tyrosine phosphatase family
E4T63_RS12390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4T63_RS12405	COG2207	Transcriptional regulator
E4T63_RS12405	COG1917	Cupin 2, conserved barrel domain protein
E4T63_RS12415	COG3328	transposase activity
E4T63_RS12455	COG0826	peptidase U32
E4T63_RS12475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4T63_RS12480	COG3938	Belongs to the proline racemase family
E4T63_RS12485	COG0531	amino acid
E4T63_RS12495	COG3639	organic phosphonate transmembrane transporter activity
E4T63_RS12500	COG3639	organic phosphonate transmembrane transporter activity
E4T63_RS12505	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4T63_RS12510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4T63_RS12525	COG0251	oxidation-reduction process
E4T63_RS12540	COG0583	DNA-binding transcription factor activity
E4T63_RS12545	COG2957	Belongs to the agmatine deiminase family
E4T63_RS12560	COG2957	Belongs to the agmatine deiminase family
E4T63_RS12580	COG4251	negative regulation of phosphorylation
E4T63_RS12580	COG3706	GGDEF domain
E4T63_RS12580	COG2203	Gaf domain
E4T63_RS12580	COG5001	Diguanylate cyclase
E4T63_RS12770	COG3617	BRO family, N-terminal domain
E4T63_RS13005	COG2755	lipolytic protein G-D-S-L family
E4T63_RS13005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4T63_RS13010	COG2135	peptidase activity
E4T63_RS13025	COG0456	acetyltransferase
E4T63_RS13055	COG1522	sequence-specific DNA binding
E4T63_RS13060	COG0697	spore germination
E4T63_RS13065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4T63_RS13065	COG2755	lipolytic protein G-D-S-L family
E4T63_RS13105	COG0811	peptide transport
E4T63_RS13135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T63_RS13145	COG0456	acetyltransferase
E4T63_RS13150	COG1794	racemase activity, acting on amino acids and derivatives
E4T63_RS13165	COG3278	Belongs to the heme-copper respiratory oxidase family
E4T63_RS13180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4T63_RS13250	COG1538	Outer membrane efflux protein
E4T63_RS13260	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS13265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS13270	COG0348	domain, Protein
E4T63_RS13280	COG1285	pathogenesis
E4T63_RS13295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4T63_RS13305	COG3568	Endonuclease Exonuclease Phosphatase
E4T63_RS13370	COG1640	4-alpha-glucanotransferase
E4T63_RS13375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4T63_RS13380	COG0297	glycogen (starch) synthase activity
E4T63_RS13385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T63_RS13390	COG0596	Alpha beta hydrolase
E4T63_RS13395	COG1238	metal cluster binding
E4T63_RS13405	COG0840	transmembrane signaling receptor activity
E4T63_RS13450	COG2366	antibiotic biosynthetic process
E4T63_RS13505	COG2233	PERMEase
E4T63_RS13520	COG0010	Belongs to the arginase family
E4T63_RS13525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4T63_RS13570	COG3634	alkyl hydroperoxide reductase activity
E4T63_RS13590	COG2200	EAL domain
E4T63_RS13610	COG0667	Aldo Keto reductase
E4T63_RS13615	COG0583	DNA-binding transcription factor activity
E4T63_RS13620	COG2271	Major facilitator Superfamily
E4T63_RS13625	COG3835	regulator
E4T63_RS13635	COG1929	Belongs to the glycerate kinase type-1 family
E4T63_RS13665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T63_RS13675	COG1609	Transcriptional regulator
E4T63_RS13685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T63_RS13690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS13695	COG0745	RESPONSE REGULATOR receiver
E4T63_RS13700	COG2205	protein histidine kinase activity
E4T63_RS13705	COG1335	isochorismatase
E4T63_RS13715	COG1595	DNA-templated transcription, initiation
E4T63_RS13730	COG1024	Enoyl-CoA hydratase
E4T63_RS13735	COG2816	NAD+ diphosphatase activity
E4T63_RS13750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T63_RS13770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T63_RS13775	COG2822	iron ion transport
E4T63_RS13785	COG2822	iron ion transport
E4T63_RS13790	COG0672	)-iron permease
E4T63_RS13800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T63_RS13810	COG0183	Belongs to the thiolase family
E4T63_RS13815	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS13820	COG1024	Enoyl-CoA hydratase
E4T63_RS13825	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS13830	COG1024	Enoyl-CoA hydratase
E4T63_RS13840	COG2814	Major facilitator Superfamily
E4T63_RS13865	COG2076	Multidrug Resistance protein
E4T63_RS13870	COG2076	Multidrug Resistance protein
E4T63_RS13875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T63_RS13880	COG0726	polysaccharide deacetylase
E4T63_RS13885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T63_RS13885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4T63_RS13890	COG0463	Glycosyl transferase, family 2
E4T63_RS13895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T63_RS13900	COG4974	Belongs to the 'phage' integrase family
E4T63_RS13905	COG3842	ATPase activity
E4T63_RS13920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T63_RS13925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4T63_RS13935	COG2205	protein histidine kinase activity
E4T63_RS13945	COG3008	intermembrane lipid transfer
E4T63_RS13950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS13960	COG0174	glutamine synthetase
E4T63_RS13970	COG1595	DNA-templated transcription, initiation
E4T63_RS13975	COG3712	iron ion homeostasis
E4T63_RS13980	COG4774	siderophore transport
E4T63_RS13990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4T63_RS14010	COG4221	oxidoreductase activity
E4T63_RS14015	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS14020	COG1301	dicarboxylic acid transport
E4T63_RS14030	COG0583	DNA-binding transcription factor activity
E4T63_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS14045	COG1942	4-Oxalocrotonate Tautomerase
E4T63_RS14050	COG0583	DNA-binding transcription factor activity
E4T63_RS14055	COG3237	CsbD-like
E4T63_RS14065	COG1309	transcriptional regulator
E4T63_RS14075	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS14100	COG3046	protein related to deoxyribodipyrimidine photolyase
E4T63_RS14105	COG4191	Histidine kinase
E4T63_RS14105	COG0784	Response regulator, receiver
E4T63_RS14110	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E4T63_RS14125	COG3781	membrane
E4T63_RS14140	COG3642	lipopolysaccharide core region biosynthetic process
E4T63_RS14150	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS14175	COG1132	(ABC) transporter
E4T63_RS14205	COG3300	MHYT domain
E4T63_RS14205	COG5001	Diguanylate cyclase
E4T63_RS14215	COG1335	isochorismatase
E4T63_RS14220	COG0583	DNA-binding transcription factor activity
E4T63_RS14295	COG0174	glutamine synthetase
E4T63_RS14305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS14380	COG3276	selenocysteine insertion sequence binding
E4T63_RS14385	COG1921	L-seryl-tRNASec selenium transferase activity
E4T63_RS14390	COG3058	Necessary for formate dehydrogenase activity
E4T63_RS14395	COG2864	formate dehydrogenase
E4T63_RS14400	COG0437	4 iron, 4 sulfur cluster binding
E4T63_RS14405	COG0243	molybdopterin cofactor binding
E4T63_RS14405	COG3383	formate dehydrogenase (NAD+) activity
E4T63_RS14410	COG0243	molybdopterin cofactor binding
E4T63_RS14410	COG3383	formate dehydrogenase (NAD+) activity
E4T63_RS14415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4T63_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS14450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T63_RS14450	COG1199	ATP-dependent helicase activity
E4T63_RS14470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E4T63_RS14475	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E4T63_RS14525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS14540	COG0210	DNA helicase
E4T63_RS14555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS14565	COG3321	synthase
E4T63_RS14565	COG0604	alcohol dehydrogenase
E4T63_RS14575	COG2814	Major facilitator Superfamily
E4T63_RS14610	COG1566	PFAM secretion protein HlyD family protein
E4T63_RS14630	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E4T63_RS14645	COG2205	protein histidine kinase activity
E4T63_RS14645	COG0784	Response regulator, receiver
E4T63_RS14645	COG2198	Histidine kinase
E4T63_RS14655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4T63_RS14660	COG0784	Response regulator, receiver
E4T63_RS14660	COG2205	protein histidine kinase activity
E4T63_RS14660	COG2198	Histidine kinase
E4T63_RS14690	COG1175	transmembrane transport
E4T63_RS14710	COG0246	Mannitol dehydrogenase
E4T63_RS14720	COG1070	Carbohydrate kinase
E4T63_RS14780	COG4574	serine-type endopeptidase inhibitor activity
E4T63_RS14790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T63_RS14800	COG0598	Magnesium transport protein CorA
E4T63_RS14810	COG0456	acetyltransferase
E4T63_RS14815	COG2133	pyrroloquinoline quinone binding
E4T63_RS14825	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E4T63_RS14835	COG0488	(ABC) transporter
E4T63_RS14850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4T63_RS14855	COG0583	DNA-binding transcription factor activity
E4T63_RS14870	COG1968	undecaprenyl-diphosphatase activity
E4T63_RS14875	COG0840	transmembrane signaling receptor activity
E4T63_RS14925	COG2204	response regulator
E4T63_RS14940	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4T63_RS14945	COG0561	phosphatase activity
E4T63_RS14950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4T63_RS14955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E4T63_RS14965	COG2194	sulfuric ester hydrolase activity
E4T63_RS15010	COG2169	Transcriptional regulator
E4T63_RS15010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4T63_RS15020	COG0604	alcohol dehydrogenase
E4T63_RS15045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4T63_RS15055	COG0488	(ABC) transporter
E4T63_RS15075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T63_RS15145	COG0322	excinuclease ABC activity
E4T63_RS15150	COG2197	response regulator
E4T63_RS15165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4T63_RS15175	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4T63_RS15180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T63_RS15185	COG4166	transmembrane transport
E4T63_RS15190	COG4174	ABC transporter (Permease)
E4T63_RS15195	COG4239	(ABC) transporter, permease
E4T63_RS15200	COG4172	Belongs to the ABC transporter superfamily
E4T63_RS15205	COG2204	response regulator
E4T63_RS15210	COG2610	gluconate transmembrane transporter activity
E4T63_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS15220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T63_RS15235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T63_RS15240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T63_RS15265	COG0765	amino acid transport
E4T63_RS15270	COG0765	amino acid transport
E4T63_RS15275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS15295	COG1253	flavin adenine dinucleotide binding
E4T63_RS15360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4T63_RS15360	COG0316	Belongs to the HesB IscA family
E4T63_RS15365	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4T63_RS15410	COG0616	signal peptide processing
E4T63_RS15425	COG4172	Belongs to the ABC transporter superfamily
E4T63_RS15430	COG4239	(ABC) transporter, permease
E4T63_RS15435	COG4174	ABC transporter (Permease)
E4T63_RS15440	COG4166	transmembrane transport
E4T63_RS15445	COG4206	TonB-dependent receptor
E4T63_RS15460	COG4206	TonB-dependent receptor
E4T63_RS15465	COG3712	iron ion homeostasis
E4T63_RS15470	COG1595	DNA-templated transcription, initiation
E4T63_RS15475	COG1024	Enoyl-CoA hydratase
E4T63_RS15475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4T63_RS15510	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T63_RS15515	COG1366	Belongs to the anti-sigma-factor antagonist family
E4T63_RS15520	COG2172	sigma factor antagonist activity
E4T63_RS15535	COG0784	Response regulator, receiver
E4T63_RS15535	COG4191	Histidine kinase
E4T63_RS15555	COG0784	Response regulator, receiver
E4T63_RS15555	COG4191	Histidine kinase
E4T63_RS15585	COG0587	DNA-directed DNA polymerase activity
E4T63_RS15600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4T63_RS15650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS15655	COG4521	taurine ABC transporter
E4T63_RS15670	COG2081	HI0933 family
E4T63_RS15675	COG2188	Transcriptional regulator
E4T63_RS15680	COG0673	inositol 2-dehydrogenase activity
E4T63_RS15835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T63_RS15870	COG0714	Associated with various cellular activities
E4T63_RS15905	COG0420	3'-5' exonuclease activity
E4T63_RS15940	COG2706	6-phosphogluconolactonase activity
E4T63_RS15950	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS15975	COG1609	Transcriptional regulator
E4T63_RS16000	COG2267	carboxylic ester hydrolase activity
E4T63_RS16005	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS16015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4T63_RS16020	COG2186	Transcriptional regulator
E4T63_RS16035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4T63_RS16045	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T63_RS16055	COG3842	ATPase activity
E4T63_RS16065	COG0024	Methionine aminopeptidase
E4T63_RS16075	COG0248	Ppx GppA phosphatase
E4T63_RS16080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4T63_RS16090	COG0626	cystathionine gamma-synthase activity
E4T63_RS16130	COG2207	Transcriptional regulator
E4T63_RS16135	COG0154	amidase activity
E4T63_RS16145	COG0861	Integral membrane protein TerC family
E4T63_RS16160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T63_RS16170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T63_RS16315	COG0642	Histidine kinase
E4T63_RS16320	COG1971	Probably functions as a manganese efflux pump
E4T63_RS16330	COG0028	Belongs to the TPP enzyme family
E4T63_RS16340	COG0583	DNA-binding transcription factor activity
E4T63_RS16355	COG0625	glutathione transferase activity
E4T63_RS16380	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS16385	COG4221	oxidoreductase activity
E4T63_RS16390	COG2267	carboxylic ester hydrolase activity
E4T63_RS16395	COG3321	synthase
E4T63_RS16395	COG0604	alcohol dehydrogenase
E4T63_RS16405	COG2207	Transcriptional regulator
E4T63_RS16430	COG0604	alcohol dehydrogenase
E4T63_RS16435	COG0583	DNA-binding transcription factor activity
E4T63_RS16455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4T63_RS16455	COG0604	alcohol dehydrogenase
E4T63_RS16455	COG3321	synthase
E4T63_RS16455	COG4221	oxidoreductase activity
E4T63_RS16475	COG2199	diguanylate cyclase activity
E4T63_RS16490	COG0500	methyltransferase
E4T63_RS16520	COG2072	flavoprotein involved in K transport
E4T63_RS16545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4T63_RS16550	COG0625	glutathione transferase activity
E4T63_RS16560	COG0583	DNA-binding transcription factor activity
E4T63_RS16565	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS16570	COG0477	Major facilitator Superfamily
E4T63_RS16575	COG0583	DNA-binding transcription factor activity
E4T63_RS16590	COG2995	paraquat-inducible protein a
E4T63_RS16595	COG0247	lactate metabolic process
E4T63_RS16595	COG0277	FAD linked oxidase domain protein
E4T63_RS16600	COG0583	DNA-binding transcription factor activity
E4T63_RS16640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T63_RS16650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS16655	COG2135	peptidase activity
E4T63_RS16685	COG1611	Belongs to the LOG family
E4T63_RS16700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T63_RS16715	COG2111	Na H antiporter
E4T63_RS16715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4T63_RS16720	COG1006	Multisubunit Na H antiporter MnhC subunit
E4T63_RS16725	COG0651	ATP synthesis coupled electron transport
E4T63_RS16735	COG2212	antiporter activity
E4T63_RS16740	COG1320	monovalent cation:proton antiporter activity
E4T63_RS16755	COG4774	siderophore transport
E4T63_RS16790	COG0840	transmembrane signaling receptor activity
E4T63_RS16810	COG4335	DNA alkylation repair
E4T63_RS16870	COG3038	cytochrome b561
E4T63_RS16880	COG1022	Amp-dependent synthetase and ligase
E4T63_RS16920	COG0431	NADPH-dependent FMN reductase
E4T63_RS16925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T63_RS16930	COG0640	Transcriptional regulator
E4T63_RS16960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E4T63_RS16965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4T63_RS16980	COG0583	DNA-binding transcription factor activity
E4T63_RS16985	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E4T63_RS16995	COG0288	reversible hydration of carbon dioxide
E4T63_RS17000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4T63_RS17005	COG2066	Belongs to the glutaminase family
E4T63_RS17075	COG1294	oxidase, subunit
E4T63_RS17080	COG1271	oxidase subunit
E4T63_RS17090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4T63_RS17095	COG3781	membrane
E4T63_RS17110	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T63_RS17120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4T63_RS17130	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4T63_RS17145	COG0174	glutamine synthetase
E4T63_RS17150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS17165	COG0583	DNA-binding transcription factor activity
E4T63_RS17180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T63_RS17215	COG1917	Cupin 2, conserved barrel domain protein
E4T63_RS17215	COG1396	sequence-specific DNA binding
E4T63_RS17220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS17225	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS17230	COG0174	glutamine synthetase
E4T63_RS17235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4T63_RS17240	COG3842	ATPase activity
E4T63_RS17245	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T63_RS17250	COG1177	transmembrane transport
E4T63_RS17290	COG1620	l-lactate permease
E4T63_RS17295	COG2080	2 iron, 2 sulfur cluster binding
E4T63_RS17300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4T63_RS17305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4T63_RS17310	COG3415	Transposase
E4T63_RS17310	COG2801	Transposase and inactivated derivatives
E4T63_RS17330	COG1073	alpha beta
E4T63_RS17350	COG0579	oxidoreductase
E4T63_RS17425	COG4106	trans-aconitate 2-methyltransferase activity
E4T63_RS17430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4T63_RS17450	COG0583	DNA-binding transcription factor activity
E4T63_RS17455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4T63_RS17550	COG0531	amino acid
E4T63_RS17565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4T63_RS17575	COG3706	GGDEF domain
E4T63_RS17580	COG2072	flavoprotein involved in K transport
E4T63_RS17585	COG2267	carboxylic ester hydrolase activity
E4T63_RS17590	COG0277	FAD linked oxidase domain protein
E4T63_RS17595	COG0277	FAD linked oxidase domain protein
E4T63_RS17600	COG0247	lactate metabolic process
E4T63_RS17605	COG5383	Protein conserved in bacteria
E4T63_RS17665	COG2720	vancomycin resistance protein
E4T63_RS17695	COG0577	efflux transmembrane transporter activity
E4T63_RS17740	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS17750	COG1216	Glycosyl transferase, family 2
E4T63_RS17760	COG0726	polysaccharide deacetylase
E4T63_RS17810	COG0583	DNA-binding transcription factor activity
E4T63_RS17825	COG1335	isochorismatase
E4T63_RS17830	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4T63_RS17875	COG1741	Belongs to the pirin family
E4T63_RS17885	COG0583	DNA-binding transcription factor activity
E4T63_RS17895	COG0604	alcohol dehydrogenase
E4T63_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS17895	COG3321	synthase
E4T63_RS17915	COG0430	RNA-3'-phosphate cyclase activity
E4T63_RS17920	COG3541	Predicted nucleotidyltransferase
E4T63_RS17925	COG1690	Belongs to the RtcB family
E4T63_RS17935	COG4650	regulator
E4T63_RS18000	COG0776	regulation of translation
E4T63_RS18005	COG0072	phenylalanine-tRNA ligase activity
E4T63_RS18010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4T63_RS18015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4T63_RS18020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4T63_RS18025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4T63_RS18030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4T63_RS18040	COG1278	Cold shock
E4T63_RS18065	COG1869	D-ribose catabolic process
E4T63_RS18070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4T63_RS18075	COG1609	Transcriptional regulator
E4T63_RS18080	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T63_RS18085	COG1129	ABC transporter
E4T63_RS18125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4T63_RS18140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS18145	COG3608	succinylglutamate desuccinylase aspartoacylase
E4T63_RS18145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T63_RS18150	COG2010	Cytochrome c
E4T63_RS18195	COG1286	toxin biosynthetic process
E4T63_RS18205	COG0285	dihydrofolate synthase activity
E4T63_RS18210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4T63_RS18215	COG0135	phosphoribosylanthranilate isomerase activity
E4T63_RS18240	COG0473	3-isopropylmalate dehydrogenase activity
E4T63_RS18245	COG2226	methyltransferase
E4T63_RS18250	COG0066	3-isopropylmalate dehydratase activity
E4T63_RS18255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4T63_RS18270	COG0443	Heat shock 70 kDa protein
E4T63_RS18275	COG2214	Heat shock protein DnaJ domain protein
E4T63_RS18290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T63_RS18305	COG0596	Alpha beta hydrolase
E4T63_RS18335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4T63_RS18350	COG0556	nucleotide-excision repair
E4T63_RS18375	COG2233	PERMEase
E4T63_RS18395	COG0708	Exodeoxyribonuclease III
E4T63_RS18410	COG3706	GGDEF domain
E4T63_RS18410	COG2203	Gaf domain
E4T63_RS18410	COG5001	Diguanylate cyclase
E4T63_RS18410	COG4251	negative regulation of phosphorylation
E4T63_RS18450	COG1522	sequence-specific DNA binding
E4T63_RS18460	COG2423	ornithine cyclodeaminase activity
E4T63_RS18465	COG1113	amino acid transport
E4T63_RS18470	COG2199	diguanylate cyclase activity
E4T63_RS18470	COG3287	FIST C domain
E4T63_RS18470	COG2200	EAL domain
E4T63_RS18475	COG0840	transmembrane signaling receptor activity
E4T63_RS18505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4T63_RS18510	COG1968	undecaprenyl-diphosphatase activity
E4T63_RS18525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4T63_RS18535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4T63_RS18550	COG1596	polysaccharide export
E4T63_RS18560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4T63_RS18605	COG3206	protein involved in exopolysaccharide biosynthesis
E4T63_RS18605	COG0489	protein tyrosine kinase activity
E4T63_RS18620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4T63_RS18630	COG2204	response regulator
E4T63_RS18655	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4T63_RS18655	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4T63_RS18675	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4T63_RS18680	COG1136	(ABC) transporter
E4T63_RS18685	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4T63_RS18695	COG0584	glycerophosphoryl diester phosphodiesterase
E4T63_RS18700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T63_RS18705	COG1477	protein flavinylation
E4T63_RS18720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4T63_RS18730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T63_RS18735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4T63_RS18740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4T63_RS18785	COG0183	Belongs to the thiolase family
E4T63_RS18790	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T63_RS18790	COG1024	Enoyl-CoA hydratase
E4T63_RS18805	COG0589	response to stress
E4T63_RS18815	COG0488	(ABC) transporter
E4T63_RS18820	COG0741	lytic transglycosylase activity
E4T63_RS18825	COG1132	(ABC) transporter
E4T63_RS18835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T63_RS18845	COG0425	Belongs to the sulfur carrier protein TusA family
E4T63_RS18850	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4T63_RS18870	COG1397	ADP-ribosylglycohydrolase
E4T63_RS18885	COG3655	Transcriptional regulator
E4T63_RS18895	COG0768	penicillin binding
E4T63_RS18945	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS18975	COG0431	NADPH-dependent FMN reductase
E4T63_RS18980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T63_RS18990	COG3829	transcription factor binding
E4T63_RS19015	COG0583	DNA-binding transcription factor activity
E4T63_RS19020	COG0066	3-isopropylmalate dehydratase activity
E4T63_RS19025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4T63_RS19065	COG1121	(ABC) transporter
E4T63_RS19070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T63_RS19095	COG0642	Histidine kinase
E4T63_RS19110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T63_RS19120	COG2267	carboxylic ester hydrolase activity
E4T63_RS19160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4T63_RS19165	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS19170	COG1024	Enoyl-CoA hydratase
E4T63_RS19185	COG3123	guanosine phosphorylase activity
E4T63_RS19190	COG0633	Ferredoxin
E4T63_RS19190	COG3217	Mosc domain protein beta barrel domain protein
E4T63_RS19205	COG3851	Histidine kinase
E4T63_RS19210	COG2197	response regulator
E4T63_RS19215	COG1597	lipid kinase activity
E4T63_RS19225	COG0303	'Molybdopterin
E4T63_RS19230	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4T63_RS19235	COG0746	molybdenum cofactor guanylyltransferase activity
E4T63_RS19245	COG0564	pseudouridine synthase activity
E4T63_RS19265	COG0004	ammonium transporteR
E4T63_RS19285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4T63_RS19295	COG2197	response regulator
E4T63_RS19300	COG2205	protein histidine kinase activity
E4T63_RS19300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS19305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4T63_RS19310	COG1956	GAF domain-containing protein
E4T63_RS19320	COG5002	protein histidine kinase activity
E4T63_RS19320	COG2205	protein histidine kinase activity
E4T63_RS19320	COG0784	Response regulator, receiver
E4T63_RS19325	COG1846	Transcriptional regulator
E4T63_RS19330	COG0386	Belongs to the glutathione peroxidase family
E4T63_RS19335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T63_RS19340	COG0436	Aminotransferase
E4T63_RS19345	COG0501	Belongs to the peptidase M48B family
E4T63_RS19350	COG0500	methyltransferase
E4T63_RS19355	COG3384	dioxygenase
E4T63_RS19370	COG1024	Enoyl-CoA hydratase
E4T63_RS19370	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T63_RS19380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E4T63_RS19385	COG3214	Protein conserved in bacteria
E4T63_RS19395	COG0583	DNA-binding transcription factor activity
E4T63_RS19405	COG0583	DNA-binding transcription factor activity
E4T63_RS19410	COG1846	Transcriptional regulator
E4T63_RS19415	COG1764	response to oxidative stress
E4T63_RS19420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4T63_RS19435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T63_RS19455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4T63_RS19485	COG1376	ErfK ybiS ycfS ynhG family protein
E4T63_RS19500	COG4181	ATPase activity
E4T63_RS19505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4T63_RS19520	COG2259	Doxx family
E4T63_RS19525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4T63_RS19530	COG0084	hydrolase, TatD family'
E4T63_RS19570	COG2205	protein histidine kinase activity
E4T63_RS19575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E4T63_RS19585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4T63_RS19610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T63_RS19615	COG4221	oxidoreductase activity
E4T63_RS19620	COG1555	photosystem II stabilization
E4T63_RS19645	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS19645	COG1216	Glycosyl transferase, family 2
E4T63_RS19675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4T63_RS19710	COG0776	regulation of translation
E4T63_RS19725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4T63_RS19730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4T63_RS19735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4T63_RS19745	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4T63_RS19765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4T63_RS19770	COG0402	S-adenosylhomocysteine deaminase activity
E4T63_RS19775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4T63_RS19780	COG0546	phosphoglycolate phosphatase activity
E4T63_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS19800	COG5001	Diguanylate cyclase
E4T63_RS19800	COG5002	protein histidine kinase activity
E4T63_RS19820	COG1054	Belongs to the UPF0176 family
E4T63_RS19825	COG0271	Belongs to the BolA IbaG family
E4T63_RS19835	COG0114	fumarate hydratase activity
E4T63_RS19840	COG0697	spore germination
E4T63_RS19850	COG0183	Belongs to the thiolase family
E4T63_RS19855	COG2326	polyphosphate kinase activity
E4T63_RS19860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4T63_RS19860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS19865	COG0367	asparagine synthase
E4T63_RS19870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4T63_RS19870	COG0189	ligase activity
E4T63_RS19880	COG3089	Belongs to the UPF0270 family
E4T63_RS19885	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4T63_RS19890	COG1742	UPF0060 membrane protein
E4T63_RS19905	COG1368	sulfuric ester hydrolase activity
E4T63_RS19925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS19930	COG2885	chlorophyll binding
E4T63_RS19930	COG3047	cAMP biosynthetic process
E4T63_RS19965	COG2207	Transcriptional regulator
E4T63_RS19970	COG1064	alcohol dehydrogenase
E4T63_RS19975	COG1414	Transcriptional regulator
E4T63_RS19980	COG2271	Major facilitator Superfamily
E4T63_RS19985	COG4948	Mandelate Racemase Muconate Lactonizing
E4T63_RS19990	COG0800	Aldolase
E4T63_RS19995	COG3734	2-keto-3-deoxy-galactonokinase
E4T63_RS20030	COG1418	mRNA catabolic process
E4T63_RS20050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4T63_RS20050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4T63_RS20060	COG1397	ADP-ribosylglycohydrolase
E4T63_RS20065	COG2188	Transcriptional regulator
E4T63_RS20070	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4T63_RS20075	COG1129	ABC transporter
E4T63_RS20080	COG1879	ABC-type sugar transport system periplasmic component
E4T63_RS20090	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS20100	COG2186	Transcriptional regulator
E4T63_RS20115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4T63_RS20125	COG0084	hydrolase, TatD family'
E4T63_RS20140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4T63_RS20145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4T63_RS20155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4T63_RS20160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4T63_RS20175	COG0416	fatty acid biosynthetic process
E4T63_RS20180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4T63_RS20190	COG0424	maF-like protein
E4T63_RS20195	COG0616	signal peptide processing
E4T63_RS20195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4T63_RS20200	COG0546	phosphoglycolate phosphatase activity
E4T63_RS20210	COG1530	ribonuclease E activity
E4T63_RS20215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4T63_RS20220	COG3608	succinylglutamate desuccinylase aspartoacylase
E4T63_RS20220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4T63_RS20240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4T63_RS20245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4T63_RS20250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4T63_RS20255	COG2835	tetraacyldisaccharide 4'-kinase activity
E4T63_RS20260	COG1663	tetraacyldisaccharide 4'-kinase activity
E4T63_RS20265	COG0848	biopolymer transport protein
E4T63_RS20270	COG0811	peptide transport
E4T63_RS20285	COG0842	Transport permease protein
E4T63_RS20290	COG1131	(ABC) transporter
E4T63_RS20295	COG0625	glutathione transferase activity
E4T63_RS20305	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS20320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4T63_RS20375	COG0840	transmembrane signaling receptor activity
E4T63_RS20385	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS20390	COG2130	NADP-dependent
E4T63_RS20400	COG0284	orotidine-5'-phosphate decarboxylase activity
E4T63_RS20425	COG0628	permease
E4T63_RS20450	COG1022	Amp-dependent synthetase and ligase
E4T63_RS20465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4T63_RS20470	COG4771	TonB-dependent receptor
E4T63_RS20480	COG5002	protein histidine kinase activity
E4T63_RS20480	COG2205	protein histidine kinase activity
E4T63_RS20480	COG0784	Response regulator, receiver
E4T63_RS20485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4T63_RS20500	COG3122	Protein conserved in bacteria
E4T63_RS20505	COG3956	TIGRFAM MazG family protein
E4T63_RS20510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T63_RS20515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T63_RS20535	COG5002	protein histidine kinase activity
E4T63_RS20535	COG0784	Response regulator, receiver
E4T63_RS20535	COG2205	protein histidine kinase activity
E4T63_RS20540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T63_RS20560	COG3118	belongs to the thioredoxin family
E4T63_RS20565	COG1393	Belongs to the ArsC family
E4T63_RS20580	COG2818	Glycosylase
E4T63_RS20585	COG0037	tRNA processing
E4T63_RS20595	COG3091	SprT-like family
E4T63_RS20600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4T63_RS20605	COG1301	dicarboxylic acid transport
E4T63_RS20610	COG1917	Cupin 2, conserved barrel domain protein
E4T63_RS20610	COG4977	sequence-specific DNA binding
E4T63_RS20635	COG2205	protein histidine kinase activity
E4T63_RS20640	COG0745	RESPONSE REGULATOR receiver
E4T63_RS20650	COG1749	Flagellar hook protein flgE
E4T63_RS20655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4T63_RS20665	COG1815	bacterial-type flagellum-dependent cell motility
E4T63_RS20670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4T63_RS20675	COG0784	Response regulator, receiver
E4T63_RS20675	COG0835	chemotaxis
E4T63_RS20685	COG2747	anti-sigma28 factor FlgM
E4T63_RS20695	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E4T63_RS20700	COG0477	Major facilitator Superfamily
E4T63_RS20750	COG2239	Acts as a magnesium transporter
E4T63_RS20780	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4T63_RS20785	COG0527	aspartate kinase activity
E4T63_RS20790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4T63_RS20795	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4T63_RS20800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4T63_RS20805	COG2988	succinylglutamate desuccinylase activity
E4T63_RS20815	COG3724	N-succinylarginine dihydrolase activity
E4T63_RS20820	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS20835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T63_RS20875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS20880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T63_RS20890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4T63_RS20930	COG0154	amidase activity
E4T63_RS20945	COG3706	GGDEF domain
E4T63_RS20965	COG0504	CTP synthase activity
E4T63_RS20980	COG0584	glycerophosphoryl diester phosphodiesterase
E4T63_RS21015	COG0306	phosphate transporter
E4T63_RS21035	COG0583	DNA-binding transcription factor activity
E4T63_RS21040	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS21050	COG0583	DNA-binding transcription factor activity
E4T63_RS21055	COG4941	Belongs to the sigma-70 factor family
E4T63_RS21060	COG3795	YCII-related domain
E4T63_RS21070	COG0456	acetyltransferase
E4T63_RS21105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4T63_RS21125	COG0436	Aminotransferase
E4T63_RS21140	COG3265	gluconokinase activity
E4T63_RS21145	COG1609	Transcriptional regulator
E4T63_RS21155	COG0583	DNA-binding transcription factor activity
E4T63_RS21165	COG2271	Major facilitator Superfamily
E4T63_RS21180	COG0583	DNA-binding transcription factor activity
E4T63_RS21215	COG0242	peptide deformylase activity
E4T63_RS21220	COG1295	ribonuclease BN
E4T63_RS21235	COG0318	PFAM AMP-dependent synthetase and ligase
E4T63_RS21245	COG2267	carboxylic ester hydrolase activity
E4T63_RS21250	COG2030	dehydratase
E4T63_RS21260	COG3530	Putative quorum-sensing-regulated virulence factor
E4T63_RS21265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4T63_RS21275	COG0800	Aldolase
E4T63_RS21290	COG1737	Transcriptional regulator
E4T63_RS21295	COG0676	glucose-6-phosphate 1-epimerase activity
E4T63_RS21310	COG0395	ABC-type sugar transport system, permease component
E4T63_RS21315	COG1175	transmembrane transport
E4T63_RS21320	COG1653	transport
E4T63_RS21360	COG3712	iron ion homeostasis
E4T63_RS21375	COG2832	Protein of unknown function (DUF454)
E4T63_RS21380	COG0840	transmembrane signaling receptor activity
E4T63_RS21385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4T63_RS21405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4T63_RS21430	COG0509	glycine decarboxylation via glycine cleavage system
E4T63_RS21435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4T63_RS21435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4T63_RS21445	COG1760	l-serine dehydratase
E4T63_RS21450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4T63_RS21455	COG1278	Cold shock
E4T63_RS21465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4T63_RS21475	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4T63_RS21480	COG0602	queuosine metabolic process
E4T63_RS21485	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4T63_RS21490	COG2885	chlorophyll binding
E4T63_RS21495	COG0823	Involved in the tonB-independent uptake of proteins
E4T63_RS21515	COG0824	Thioesterase
E4T63_RS21520	COG2255	four-way junction helicase activity
E4T63_RS21525	COG0632	four-way junction helicase activity
E4T63_RS21530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4T63_RS21540	COG0217	transcriptional regulatory protein
E4T63_RS21545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4T63_RS21560	COG0783	Belongs to the Dps family
E4T63_RS21570	COG2900	Belongs to the SlyX family
E4T63_RS21585	COG0668	transmembrane transport
E4T63_RS21590	COG1666	GTP binding
E4T63_RS21605	COG2096	Adenosyltransferase
E4T63_RS21610	COG0494	nUDIX hydrolase
E4T63_RS21620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4T63_RS21625	COG0653	protein targeting
E4T63_RS21635	COG0433	COG0433 Predicted ATPase
E4T63_RS21645	COG3415	Transposase
E4T63_RS21645	COG2801	Transposase and inactivated derivatives
E4T63_RS21650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4T63_RS21650	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS21675	COG2925	Exonuclease
E4T63_RS21700	COG0714	Associated with various cellular activities
E4T63_RS21750	COG0469	pyruvate kinase activity
E4T63_RS21770	COG1024	Enoyl-CoA hydratase
E4T63_RS21775	COG0633	Ferredoxin
E4T63_RS21775	COG0543	2 iron, 2 sulfur cluster binding
E4T63_RS21780	COG3706	GGDEF domain
E4T63_RS21805	COG4191	Histidine kinase
E4T63_RS21815	COG0477	Major facilitator Superfamily
E4T63_RS21845	COG2207	Transcriptional regulator
E4T63_RS21850	COG3842	ATPase activity
E4T63_RS21860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4T63_RS21870	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS21880	COG0583	DNA-binding transcription factor activity
E4T63_RS21885	COG2910	NAD(P)H-binding
E4T63_RS21895	COG0583	DNA-binding transcription factor activity
E4T63_RS21915	COG0477	Major facilitator Superfamily
E4T63_RS21935	COG0583	DNA-binding transcription factor activity
E4T63_RS21950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4T63_RS21980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS21985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4T63_RS21995	COG3642	lipopolysaccharide core region biosynthetic process
E4T63_RS22005	COG0642	Histidine kinase
E4T63_RS22015	COG1368	sulfuric ester hydrolase activity
E4T63_RS22020	COG0459	protein refolding
E4T63_RS22025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4T63_RS22040	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS22045	COG0489	protein tyrosine kinase activity
E4T63_RS22050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T63_RS22050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4T63_RS22055	COG4657	Part of a membrane complex involved in electron transport
E4T63_RS22060	COG2878	Part of a membrane complex involved in electron transport
E4T63_RS22065	COG4658	electron transport chain
E4T63_RS22070	COG4659	FMN binding
E4T63_RS22075	COG4660	Part of a membrane complex involved in electron transport
E4T63_RS22080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4T63_RS22090	COG2197	response regulator
E4T63_RS22100	COG0137	argininosuccinate synthase activity
E4T63_RS22110	COG0418	dihydroorotase activity
E4T63_RS22115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T63_RS22120	COG0450	alkyl hydroperoxide reductase
E4T63_RS22135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4T63_RS22140	COG0243	molybdopterin cofactor binding
E4T63_RS22150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4T63_RS22155	COG3842	ATPase activity
E4T63_RS22165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4T63_RS22175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4T63_RS22190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS22195	COG0765	amino acid transport
E4T63_RS22200	COG0765	amino acid transport
E4T63_RS22205	COG1126	abc transporter atp-binding protein
E4T63_RS22235	COG2076	Multidrug Resistance protein
E4T63_RS22250	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
E4T63_RS22255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T63_RS22270	COG4191	Histidine kinase
E4T63_RS22275	COG2204	response regulator
E4T63_RS22285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T63_RS22295	COG0583	DNA-binding transcription factor activity
E4T63_RS22305	COG1280	lysine exporter protein (LysE YggA)
E4T63_RS22320	COG5001	Diguanylate cyclase
E4T63_RS22320	COG3300	MHYT domain
E4T63_RS22330	COG1858	cytochrome C peroxidase
E4T63_RS22345	COG0531	amino acid
E4T63_RS22355	COG2197	response regulator
E4T63_RS22360	COG0069	glutamate synthase activity
E4T63_RS22370	COG1113	amino acid transport
E4T63_RS22415	COG1695	Transcriptional regulator
E4T63_RS22420	COG2375	cellular response to nickel ion
E4T63_RS22435	COG4628	conserved protein (DUF2132)
E4T63_RS22465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4T63_RS22485	COG4106	trans-aconitate 2-methyltransferase activity
E4T63_RS22490	COG0500	methyltransferase
E4T63_RS22495	COG0590	tRNA wobble adenosine to inosine editing
E4T63_RS22510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4T63_RS22510	COG0519	Catalyzes the synthesis of GMP from XMP
E4T63_RS22540	COG1570	exodeoxyribonuclease VII activity
E4T63_RS22545	COG0739	heme binding
E4T63_RS22560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4T63_RS22565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T63_RS22570	COG0436	Aminotransferase
E4T63_RS22580	COG1160	GTP binding
E4T63_RS22595	COG0124	histidyl-tRNA synthetase
E4T63_RS22600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4T63_RS22615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4T63_RS22620	COG0105	UTP biosynthetic process
E4T63_RS22630	COG0633	Ferredoxin
E4T63_RS22635	COG0443	Heat shock 70 kDa protein
E4T63_RS22640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4T63_RS22645	COG0316	Belongs to the HesB IscA family
E4T63_RS22655	COG1104	cysteine desulfurase activity
E4T63_RS22680	COG3134	Outer membrane lipoprotein
E4T63_RS22695	COG1862	Preprotein translocase
E4T63_RS22700	COG0343	queuine tRNA-ribosyltransferase activity
E4T63_RS22705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4T63_RS22750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T63_RS22755	COG0583	DNA-binding transcription factor activity
E4T63_RS22770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4T63_RS22775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4T63_RS22775	COG0785	Cytochrome C biogenesis protein
E4T63_RS22790	COG5002	protein histidine kinase activity
E4T63_RS22810	COG0109	protoheme IX farnesyltransferase activity
E4T63_RS22820	COG1845	cytochrome c oxidase, subunit III
E4T63_RS22825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4T63_RS22830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4T63_RS22840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4T63_RS22850	COG1017	nitric oxide dioxygenase activity
E4T63_RS22850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T63_RS22885	COG0840	transmembrane signaling receptor activity
E4T63_RS22915	COG5002	protein histidine kinase activity
E4T63_RS22930	COG2203	Gaf domain
E4T63_RS22930	COG3706	GGDEF domain
E4T63_RS22930	COG4251	negative regulation of phosphorylation
E4T63_RS22930	COG5001	Diguanylate cyclase
E4T63_RS22935	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4T63_RS22940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4T63_RS22955	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4T63_RS22960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4T63_RS22965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4T63_RS22970	COG0772	Belongs to the SEDS family
E4T63_RS22975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4T63_RS22980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4T63_RS22985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4T63_RS22990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4T63_RS23005	COG0275	rRNA processing
E4T63_RS23010	COG2001	Belongs to the MraZ family
E4T63_RS23025	COG3107	peptidoglycan biosynthetic process
E4T63_RS23030	COG0792	nuclease activity
E4T63_RS23035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4T63_RS23040	COG2823	Periplasmic or secreted lipoprotein
E4T63_RS23045	COG2969	positive regulation of protein catabolic process
E4T63_RS23050	COG0625	glutathione transferase activity
E4T63_RS23055	COG2857	Cytochrome c1
E4T63_RS23060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4T63_RS23065	COG0723	plastoquinol--plastocyanin reductase activity
E4T63_RS23070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4T63_RS23075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4T63_RS23080	COG0667	Aldo Keto reductase
E4T63_RS23085	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS23095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4T63_RS23100	COG0180	Tryptophanyl-tRNA synthetase
E4T63_RS23120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4T63_RS23140	COG0318	PFAM AMP-dependent synthetase and ligase
E4T63_RS23155	COG1280	lysine exporter protein (LysE YggA)
E4T63_RS23160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4T63_RS23165	COG2813	Specifically methylates the guanine in position
E4T63_RS23170	COG2119	membrane
E4T63_RS23175	COG0501	Belongs to the peptidase M48B family
E4T63_RS23180	COG0840	transmembrane signaling receptor activity
E4T63_RS23185	COG2135	peptidase activity
E4T63_RS23245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4T63_RS23250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4T63_RS23260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4T63_RS23265	COG1090	epimerase
E4T63_RS23270	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E4T63_RS23285	COG0789	Transcriptional regulator
E4T63_RS23290	COG0415	Belongs to the DNA photolyase family
E4T63_RS23300	COG4221	oxidoreductase activity
E4T63_RS23305	COG0493	'glutamate synthase
E4T63_RS23315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4T63_RS23340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4T63_RS23345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T63_RS23355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4T63_RS23360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4T63_RS23370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4T63_RS23375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4T63_RS23385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4T63_RS23390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4T63_RS23395	COG0193	aminoacyl-tRNA hydrolase activity
E4T63_RS23405	COG2223	nitrite transmembrane transporter activity
E4T63_RS23430	COG0405	Gamma-glutamyltransferase
E4T63_RS23435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4T63_RS23455	COG0477	Major facilitator Superfamily
E4T63_RS23460	COG2031	fatty acid transporter
E4T63_RS23465	COG0443	Heat shock 70 kDa protein
E4T63_RS23490	COG0288	reversible hydration of carbon dioxide
E4T63_RS23500	COG0456	acetyltransferase
E4T63_RS23525	COG3008	intermembrane lipid transfer
E4T63_RS23530	COG2995	paraquat-inducible protein a
E4T63_RS23535	COG2995	paraquat-inducible protein a
E4T63_RS23570	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4T63_RS23575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4T63_RS23580	COG1183	phosphatidylcholine synthase activity
E4T63_RS23585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4T63_RS23595	COG0028	Belongs to the TPP enzyme family
E4T63_RS23615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T63_RS23645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4T63_RS23650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4T63_RS23655	COG4558	Periplasmic binding protein
E4T63_RS23665	COG1489	DNA binding
E4T63_RS23670	COG0436	Aminotransferase
E4T63_RS23675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4T63_RS23680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4T63_RS23690	COG4191	Histidine kinase
E4T63_RS23710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4T63_RS23715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4T63_RS23725	COG0166	Belongs to the GPI family
E4T63_RS23730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4T63_RS23740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T63_RS23760	COG2823	Periplasmic or secreted lipoprotein
E4T63_RS23780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4T63_RS23785	COG0237	dephospho-CoA kinase activity
E4T63_RS23790	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4T63_RS23820	COG1252	NADH dehydrogenase
E4T63_RS23855	COG0542	response to heat
E4T63_RS23890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS23930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4T63_RS23940	COG1047	Peptidyl-prolyl cis-trans
E4T63_RS23945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4T63_RS23950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4T63_RS23955	COG0196	riboflavin kinase activity
E4T63_RS23965	COG0268	Binds directly to 16S ribosomal RNA
E4T63_RS23970	COG3045	CreA protein
E4T63_RS23975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E4T63_RS23980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4T63_RS23985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4T63_RS23990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4T63_RS23995	COG0142	geranyltranstransferase activity
E4T63_RS24005	COG2824	Alkylphosphonate utilization operon protein PhnA
E4T63_RS24010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4T63_RS24015	COG0545	Peptidyl-prolyl cis-trans isomerase
E4T63_RS24025	COG2862	Uncharacterized protein family, UPF0114
E4T63_RS24040	COG1067	ATP-dependent peptidase activity
E4T63_RS24065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T63_RS24075	COG0488	(ABC) transporter
E4T63_RS24085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4T63_RS24105	COG0523	cobalamin synthesis protein
E4T63_RS24115	COG2879	small protein
E4T63_RS24120	COG1966	Carbon starvation protein
E4T63_RS24145	COG1970	mechanosensitive ion channel activity
E4T63_RS24155	COG2197	response regulator
E4T63_RS24160	COG2813	Specifically methylates the guanine in position
E4T63_RS24170	COG1294	oxidase, subunit
E4T63_RS24175	COG1271	oxidase subunit
E4T63_RS24195	COG2252	PERMEase
E4T63_RS24200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4T63_RS24205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4T63_RS24210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4T63_RS24215	COG1309	transcriptional regulator
E4T63_RS24220	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E4T63_RS24220	COG1082	Xylose isomerase domain protein TIM barrel
E4T63_RS24225	COG0477	Major facilitator Superfamily
E4T63_RS24240	COG0673	inositol 2-dehydrogenase activity
E4T63_RS24250	COG1053	succinate dehydrogenase
E4T63_RS24255	COG0656	L-ascorbic acid biosynthetic process
E4T63_RS24260	COG2321	neutral zinc metallopeptidase
E4T63_RS24275	COG1946	Acyl-CoA thioesterase
E4T63_RS24285	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4T63_RS24295	COG0513	Belongs to the DEAD box helicase family
E4T63_RS24300	COG0697	spore germination
E4T63_RS24305	COG1522	sequence-specific DNA binding
E4T63_RS24315	COG1199	ATP-dependent helicase activity
E4T63_RS24315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T63_RS24325	COG3416	Protein conserved in bacteria
E4T63_RS24340	COG1643	Atp-dependent helicase
E4T63_RS24350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4T63_RS24360	COG1522	sequence-specific DNA binding
E4T63_RS24375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4T63_RS24385	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS24390	COG0784	Response regulator, receiver
E4T63_RS24390	COG2198	Histidine kinase
E4T63_RS24390	COG2205	protein histidine kinase activity
E4T63_RS24400	COG0352	thiamine-phosphate diphosphorylase activity
E4T63_RS24405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4T63_RS24420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4T63_RS24425	COG1702	phosphate starvation-inducible protein PhoH
E4T63_RS24430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4T63_RS24435	COG4535	Mg2 and Co2 transporter CorC
E4T63_RS24440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4T63_RS24455	COG0495	leucyl-tRNA aminoacylation
E4T63_RS24475	COG2951	lytic endotransglycosylase activity
E4T63_RS24480	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4T63_RS24485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4T63_RS24490	COG0321	lipoyl(octanoyl) transferase activity
E4T63_RS24495	COG2921	Belongs to the UPF0250 family
E4T63_RS24500	COG1686	Belongs to the peptidase S11 family
E4T63_RS24510	COG2951	lytic endotransglycosylase activity
E4T63_RS24515	COG0772	Belongs to the SEDS family
E4T63_RS24520	COG0768	penicillin binding
E4T63_RS24525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4T63_RS24535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4T63_RS24540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4T63_RS24545	COG2094	Belongs to the DNA glycosylase MPG family
E4T63_RS24550	COG0586	Pfam SNARE associated Golgi protein
E4T63_RS24560	COG1346	cytolysis
E4T63_RS24580	COG0702	epimerase
E4T63_RS24595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4T63_RS24600	COG3284	Transcriptional regulator
E4T63_RS24620	COG4303	Ethanolamine ammonia lyase large subunit
E4T63_RS24625	COG4302	ethanolamine ammonia-lyase activity
E4T63_RS24630	COG0456	acetyltransferase
E4T63_RS24635	COG0586	Pfam SNARE associated Golgi protein
E4T63_RS24640	COG3228	Belongs to the MtfA family
E4T63_RS24645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4T63_RS24660	COG4735	regulation of single-species biofilm formation
E4T63_RS24685	COG1715	Restriction endonuclease
E4T63_RS24715	COG4676	Protein conserved in bacteria
E4T63_RS24720	COG5445	Predicted secreted protein (DUF2300)
E4T63_RS24735	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E4T63_RS24740	COG4676	Protein conserved in bacteria
E4T63_RS24750	COG1722	exodeoxyribonuclease VII activity
E4T63_RS24755	COG0142	geranyltranstransferase activity
E4T63_RS24760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4T63_RS24765	COG4206	TonB-dependent receptor
E4T63_RS24770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4T63_RS24780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4T63_RS24790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4T63_RS24795	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4T63_RS24800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4T63_RS24805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4T63_RS24820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T63_RS24820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4T63_RS24825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4T63_RS24840	COG3118	belongs to the thioredoxin family
E4T63_RS24875	COG3047	cAMP biosynthetic process
E4T63_RS24880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4T63_RS24890	COG1201	RNA secondary structure unwinding
E4T63_RS24895	COG0668	transmembrane transport
E4T63_RS24900	COG2814	Major facilitator Superfamily
E4T63_RS24915	COG3568	Endonuclease Exonuclease Phosphatase
E4T63_RS24920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T63_RS24925	COG0392	lysyltransferase activity
E4T63_RS24950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4T63_RS24955	COG3789	protein conserved in bacteria
E4T63_RS24975	COG3766	membrane
E4T63_RS24985	COG0754	glutathionylspermidine amidase activity
E4T63_RS24990	COG0629	single-stranded DNA binding
E4T63_RS24995	COG2814	Major facilitator Superfamily
E4T63_RS25000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4T63_RS25005	COG2193	ferroxidase activity
E4T63_RS25015	COG0203	ribosomal protein L17
E4T63_RS25020	COG0202	RNA polymerase activity
E4T63_RS25025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4T63_RS25030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4T63_RS25035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4T63_RS25040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4T63_RS25050	COG0200	Binds to the 23S rRNA
E4T63_RS25055	COG1841	ribosomal large subunit assembly
E4T63_RS25060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4T63_RS25065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4T63_RS25070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4T63_RS25075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4T63_RS25080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4T63_RS25085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4T63_RS25090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4T63_RS25095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4T63_RS25100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4T63_RS25105	COG0255	Belongs to the universal ribosomal protein uL29 family
E4T63_RS25110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4T63_RS25115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4T63_RS25120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4T63_RS25125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4T63_RS25130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4T63_RS25135	COG0089	rRNA binding
E4T63_RS25140	COG0088	Forms part of the polypeptide exit tunnel
E4T63_RS25145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4T63_RS25150	COG0051	transcription antitermination factor activity, RNA binding
E4T63_RS25155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4T63_RS25160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4T63_RS25165	COG0049	tRNA binding
E4T63_RS25170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4T63_RS25175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4T63_RS25180	COG0085	RNA polymerase activity
E4T63_RS25185	COG0222	ribosome binding
E4T63_RS25190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4T63_RS25195	COG0081	regulation of translation
E4T63_RS25200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4T63_RS25220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4T63_RS25245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E4T63_RS25285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4T63_RS25295	COG0739	heme binding
E4T63_RS25300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4T63_RS25305	COG0316	Belongs to the HesB IscA family
E4T63_RS25310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4T63_RS25315	COG1981	membrane
E4T63_RS25330	COG1028	Short-chain dehydrogenase reductase Sdr
E4T63_RS25335	COG0537	adenosine 5'-monophosphoramidase activity
E4T63_RS25340	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E4T63_RS25345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E4T63_RS25350	COG1765	OsmC-like protein
E4T63_RS25365	COG0134	indole-3-glycerol-phosphate synthase activity
E4T63_RS25370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4T63_RS25375	COG0512	Glutamine amidotransferase of anthranilate synthase
E4T63_RS25395	COG0546	phosphoglycolate phosphatase activity
E4T63_RS25400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4T63_RS25405	COG1454	alcohol dehydrogenase
E4T63_RS25415	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T63_RS25425	COG3842	ATPase activity
E4T63_RS25430	COG2197	response regulator
E4T63_RS25445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4T63_RS25450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4T63_RS25455	COG3178	'Phosphotransferase
E4T63_RS25460	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4T63_RS25465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4T63_RS25470	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4T63_RS25475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4T63_RS25480	COG2967	ApaG domain
E4T63_RS25485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4T63_RS25490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4T63_RS25495	COG2766	serine protein kinase
E4T63_RS25500	COG2718	Belongs to the UPF0229 family
E4T63_RS25505	COG2719	SpoVR family
E4T63_RS25510	COG0617	tRNA 3'-terminal CCA addition
E4T63_RS25520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4T63_RS25525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4T63_RS25530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4T63_RS25535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4T63_RS25540	COG0358	DNA primase activity
E4T63_RS25545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4T63_RS25610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4T63_RS25615	COG1025	Belongs to the peptidase M16 family
E4T63_RS25625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4T63_RS25630	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E4T63_RS25640	COG0535	radical SAM domain protein
E4T63_RS25660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4T63_RS25665	COG0583	DNA-binding transcription factor activity
E4T63_RS25670	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS25675	COG3706	GGDEF domain
E4T63_RS25680	COG1960	acyl-CoA dehydrogenase activity
E4T63_RS25700	COG1073	alpha beta
E4T63_RS25700	COG2226	methyltransferase
E4T63_RS25705	COG0156	8-amino-7-oxononanoate synthase activity
E4T63_RS25710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4T63_RS25715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4T63_RS25720	COG2005	Transcriptional regulator
E4T63_RS25720	COG3585	molybdate ion transport
E4T63_RS25730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4T63_RS25745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4T63_RS25750	COG4566	intracellular signal transduction
E4T63_RS25760	COG1199	ATP-dependent helicase activity
E4T63_RS25760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4T63_RS25765	COG1595	DNA-templated transcription, initiation
E4T63_RS25770	COG3712	iron ion homeostasis
E4T63_RS25775	COG4774	siderophore transport
E4T63_RS25800	COG4452	Inner membrane protein CreD
E4T63_RS25805	COG2205	protein histidine kinase activity
E4T63_RS25810	COG0745	RESPONSE REGULATOR receiver
E4T63_RS25815	COG0189	ligase activity
E4T63_RS25815	COG4067	protein conserved in archaea
E4T63_RS25820	COG0204	Acyl-transferase
E4T63_RS25830	COG1595	DNA-templated transcription, initiation
E4T63_RS25840	COG1063	alcohol dehydrogenase
E4T63_RS25870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4T63_RS25895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T63_RS25895	COG1017	nitric oxide dioxygenase activity
E4T63_RS25905	COG4638	Rieske (2fe-2S)
E4T63_RS25915	COG1858	cytochrome C peroxidase
E4T63_RS25930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4T63_RS25935	COG0247	lactate metabolic process
E4T63_RS25935	COG2181	nitrate reductase activity
E4T63_RS25940	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4T63_RS25940	COG1902	pentaerythritol trinitrate reductase activity
E4T63_RS25985	COG3246	L-lysine catabolic process to acetate
E4T63_RS25990	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4T63_RS26015	COG1760	l-serine dehydratase
E4T63_RS26025	COG4176	ABC-type proline glycine betaine transport system permease component
E4T63_RS26030	COG4175	Glycine betaine
E4T63_RS26035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4T63_RS26040	COG1309	transcriptional regulator
E4T63_RS26045	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS26050	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4T63_RS26060	COG0312	modulator of DNA gyrase
E4T63_RS26065	COG0477	Major facilitator Superfamily
E4T63_RS26070	COG0513	Belongs to the DEAD box helicase family
E4T63_RS26080	COG2081	HI0933 family
E4T63_RS26085	COG1289	transmembrane transporter activity
E4T63_RS26095	COG2153	protein acetylation
E4T63_RS26105	COG1451	nucleotide metabolic process
E4T63_RS26140	COG0126	phosphoglycerate kinase activity
E4T63_RS26145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4T63_RS26155	COG0640	Transcriptional regulator
E4T63_RS26160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4T63_RS26165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4T63_RS26210	COG1301	dicarboxylic acid transport
E4T63_RS26215	COG2116	formate transmembrane transporter activity
E4T63_RS26225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4T63_RS26235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4T63_RS26245	COG0513	Belongs to the DEAD box helicase family
E4T63_RS26250	COG2353	YceI-like domain
E4T63_RS26255	COG3038	cytochrome b561
E4T63_RS26270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4T63_RS26275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS26295	COG1272	protein, Hemolysin III
E4T63_RS26335	COG3052	prosthetic group binding
E4T63_RS26340	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4T63_RS26360	COG2198	Histidine kinase
E4T63_RS26360	COG0643	Histidine kinase
E4T63_RS26360	COG0784	Response regulator, receiver
E4T63_RS26385	COG0189	ligase activity
E4T63_RS26395	COG1678	Uncharacterized ACR, COG1678
E4T63_RS26400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4T63_RS26405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4T63_RS26410	COG0540	Belongs to the ATCase OTCase family
E4T63_RS26415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4T63_RS26425	COG0791	NLP P60 protein
E4T63_RS26455	COG1872	DUF167
E4T63_RS26460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T63_RS26465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4T63_RS26465	COG2813	Specifically methylates the guanine in position
E4T63_RS26475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4T63_RS26480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4T63_RS26490	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
E4T63_RS26495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4T63_RS26500	COG2022	thiamine diphosphate biosynthetic process
E4T63_RS26510	COG2363	Small membrane protein
E4T63_RS26515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4T63_RS26525	COG2177	Part of the ABC transporter FtsEX involved in
E4T63_RS26530	COG2884	Cell division ATP-binding protein ftsE
E4T63_RS26535	COG0552	protein localization to endoplasmic reticulum
E4T63_RS26540	COG0612	Peptidase, M16
E4T63_RS26545	COG0612	Peptidase, M16
E4T63_RS26550	COG0742	ribosomal rna small subunit methyltransferase
E4T63_RS26560	COG0429	hydrolase of the alpha beta-hydrolase fold
E4T63_RS26595	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4T63_RS26600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4T63_RS26605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4T63_RS26615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4T63_RS26625	COG0693	protein deglycase activity
E4T63_RS26630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4T63_RS26650	COG0129	dihydroxy-acid dehydratase activity
E4T63_RS26660	COG1823	symporter activity
E4T63_RS26675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4T63_RS26690	COG1840	ABC-type Fe3 transport system, periplasmic component
E4T63_RS26695	COG1178	ABC-type Fe3 transport system permease component
E4T63_RS26700	COG3842	ATPase activity
E4T63_RS26705	COG0583	DNA-binding transcription factor activity
E4T63_RS26715	COG0789	Transcriptional regulator
E4T63_RS26725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4T63_RS26730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4T63_RS26735	COG0730	response to heat
E4T63_RS26745	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E4T63_RS26750	COG0494	nUDIX hydrolase
E4T63_RS26765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4T63_RS26770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4T63_RS26775	COG3204	pilus organization
E4T63_RS26780	COG3204	pilus organization
E4T63_RS26785	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4T63_RS26790	COG0277	FAD linked oxidase domain protein
E4T63_RS26795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4T63_RS26805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS26810	COG1683	Conserved Protein
E4T63_RS26850	COG1177	transmembrane transport
E4T63_RS26855	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4T63_RS26860	COG3842	ATPase activity
E4T63_RS26880	COG0174	glutamine synthetase
E4T63_RS26885	COG0174	glutamine synthetase
E4T63_RS26900	COG1116	anion transmembrane transporter activity
E4T63_RS26905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4T63_RS26910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4T63_RS26915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4T63_RS26920	COG0431	NADPH-dependent FMN reductase
E4T63_RS26925	COG0450	alkyl hydroperoxide reductase
E4T63_RS26935	COG4521	taurine ABC transporter
E4T63_RS26940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4T63_RS26940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4T63_RS26960	COG1522	sequence-specific DNA binding
E4T63_RS26970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4T63_RS26980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4T63_RS26980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4T63_RS26985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4T63_RS26990	COG0509	glycine decarboxylation via glycine cleavage system
E4T63_RS26995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4T63_RS27000	COG1178	ABC-type Fe3 transport system permease component
E4T63_RS27010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T63_RS27015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4T63_RS27020	COG0006	proline dipeptidase activity
E4T63_RS27025	COG3079	Belongs to the UPF0149 family
E4T63_RS27045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4T63_RS27055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4T63_RS27060	COG0842	Transport permease protein
E4T63_RS27060	COG1129	ABC transporter
E4T63_RS27065	COG0842	Transport permease protein
E4T63_RS27090	COG2271	Major facilitator Superfamily
E4T63_RS27110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4T63_RS27130	COG2186	Transcriptional regulator
E4T63_RS27135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS27140	COG0765	amino acid transport
E4T63_RS27145	COG0765	amino acid transport
E4T63_RS27150	COG1126	abc transporter atp-binding protein
E4T63_RS27155	COG0248	Ppx GppA phosphatase
E4T63_RS27160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4T63_RS27170	COG0586	Pfam SNARE associated Golgi protein
E4T63_RS27175	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4T63_RS27180	COG1671	Belongs to the UPF0178 family
E4T63_RS27185	COG0672	)-iron permease
E4T63_RS27190	COG0583	DNA-binding transcription factor activity
E4T63_RS27220	COG1280	lysine exporter protein (LysE YggA)
E4T63_RS27230	COG0488	(ABC) transporter
E4T63_RS27255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4T63_RS27275	COG0181	hydroxymethylbilane synthase activity
E4T63_RS27285	COG0165	Argininosuccinate lyase
E4T63_RS27290	COG0625	glutathione transferase activity
E4T63_RS27310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4T63_RS27320	COG1965	Belongs to the frataxin family
E4T63_RS27335	COG0019	diaminopimelate decarboxylase activity
E4T63_RS27340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4T63_RS27350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4T63_RS27355	COG1011	Hydrolase
E4T63_RS27365	COG0432	Pfam Uncharacterised protein family UPF0047
E4T63_RS27370	COG0004	ammonium transporteR
E4T63_RS27375	COG0347	Belongs to the P(II) protein family
E4T63_RS27385	COG0606	chelatase, subunit chli
E4T63_RS27395	COG0840	transmembrane signaling receptor activity
E4T63_RS27400	COG0583	DNA-binding transcription factor activity
E4T63_RS27405	COG0534	Mate efflux family protein
E4T63_RS27425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4T63_RS27430	COG0427	acetyl-CoA hydrolase
E4T63_RS27445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4T63_RS27455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS27470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4T63_RS27480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4T63_RS27490	COG3188	usher protein
E4T63_RS27505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T63_RS27515	COG1012	belongs to the aldehyde dehydrogenase family
E4T63_RS27525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4T63_RS27530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4T63_RS27535	COG0747	negative chemotaxis
E4T63_RS27540	COG2003	Belongs to the UPF0758 family
E4T63_RS27545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4T63_RS27550	COG0756	dUTP diphosphatase activity
E4T63_RS27555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4T63_RS27560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4T63_RS27565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4T63_RS27570	COG0708	Exodeoxyribonuclease III
E4T63_RS27575	COG0786	glutamate:sodium symporter activity
E4T63_RS27585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4T63_RS27590	COG1561	YicC-like family, N-terminal region
E4T63_RS27595	COG0194	GDP metabolic process
E4T63_RS27600	COG1758	RNA polymerase activity
E4T63_RS27605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4T63_RS27630	COG0848	biopolymer transport protein
E4T63_RS27640	COG0583	DNA-binding transcription factor activity
E4T63_RS27645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4T63_RS27700	COG1090	epimerase
E4T63_RS27735	COG0515	serine threonine protein kinase
E4T63_RS27735	COG2815	serine threonine protein kinase
E4T63_RS27865	COG3161	chorismate lyase activity
E4T63_RS27870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4T63_RS27895	COG1253	flavin adenine dinucleotide binding
E4T63_RS27900	COG0739	heme binding
E4T63_RS27910	COG0704	Plays a role in the regulation of phosphate uptake
E4T63_RS27915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4T63_RS27920	COG0573	inorganic phosphate transmembrane transporter activity
E4T63_RS27940	COG0477	Major facilitator Superfamily
E4T63_RS27945	COG1607	acyl-coa hydrolase
E4T63_RS27975	COG0583	DNA-binding transcription factor activity
E4T63_RS27980	COG1027	Aspartate ammonia-lyase
E4T63_RS27985	COG1115	amino acid carrier protein
E4T63_RS27990	COG0252	asparaginase activity
E4T63_RS28050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4T63_RS28055	COG0765	amino acid transport
E4T63_RS28065	COG0511	ligase activity, forming carbon-carbon bonds
E4T63_RS28065	COG5016	pyruvate
E4T63_RS28070	COG0439	Biotin carboxylase
E4T63_RS28075	COG0583	DNA-binding transcription factor activity
E4T63_RS28100	COG0210	DNA helicase
E4T63_RS28120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4T63_RS28120	COG4651	solute:proton antiporter activity
E4T63_RS28125	COG1607	acyl-coa hydrolase
E4T63_RS28130	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4T63_RS28140	COG0523	cobalamin synthesis protein
E4T63_RS28165	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4T63_RS28170	COG1469	GTP cyclohydrolase I activity
E4T63_RS28175	COG1121	(ABC) transporter
E4T63_RS28180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4T63_RS28185	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4T63_RS28195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4T63_RS28205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4T63_RS28210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4T63_RS28215	COG2217	Heavy metal translocating P-type atpase
E4T63_RS28235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4T63_RS28240	COG1522	sequence-specific DNA binding
E4T63_RS28260	COG2226	methyltransferase
E4T63_RS28265	COG2755	lipolytic protein G-D-S-L family
E4T63_RS28265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4T63_RS28310	COG0438	transferase activity, transferring glycosyl groups
E4T63_RS28325	COG1017	nitric oxide dioxygenase activity
E4T63_RS28325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4T63_RS28330	COG0625	glutathione transferase activity
E4T63_RS28335	COG0583	DNA-binding transcription factor activity
E4T63_RS28340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4T63_RS28345	COG1349	DNA-binding transcription factor activity
E4T63_RS28350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4T63_RS28355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4T63_RS28360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4T63_RS28365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4T63_RS28370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4T63_RS28375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4T63_RS28380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4T63_RS28390	COG0356	it plays a direct role in the translocation of protons across the membrane
E4T63_RS28395	COG3312	ion transport
E4T63_RS28400	COG1475	DNA binding
E4T63_RS28405	COG1192	Involved in chromosome partitioning
E4T63_RS28410	COG0357	Ribosomal RNA small subunit methyltransferase G
E4T63_RS28415	COG0445	tRNA wobble uridine modification
E4T63_RS28425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4T63_RS28430	COG0706	membrane insertase activity
E4T63_RS28435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4T63_RS28440	COG0594	ribonuclease P activity
E4T63_RS28445	COG0230	Belongs to the bacterial ribosomal protein bL34 family