locus-tag	class	description
HZ99_RS00010	COG0768	penicillin binding
HZ99_RS00030	COG0473	3-isopropylmalate dehydrogenase activity
HZ99_RS00040	COG0417	DNA replication proofreading
HZ99_RS00055	COG1595	DNA-templated transcription, initiation
HZ99_RS00060	COG3712	iron ion homeostasis
HZ99_RS00070	COG0728	peptidoglycan biosynthetic process
HZ99_RS00135	COG3712	iron ion homeostasis
HZ99_RS00140	COG1595	DNA-templated transcription, initiation
HZ99_RS00150	COG4977	sequence-specific DNA binding
HZ99_RS00160	COG3387	PFAM Glycoside hydrolase 15-related
HZ99_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS00170	COG2207	Transcriptional regulator
HZ99_RS00190	COG1309	transcriptional regulator
HZ99_RS00220	COG0657	acetylesterase activity
HZ99_RS00270	COG0577	efflux transmembrane transporter activity
HZ99_RS00270	COG1136	(ABC) transporter
HZ99_RS00275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS00290	COG2197	response regulator
HZ99_RS00295	COG2205	protein histidine kinase activity
HZ99_RS00295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS00305	COG0656	L-ascorbic acid biosynthetic process
HZ99_RS00320	COG4206	TonB-dependent receptor
HZ99_RS00350	COG0475	glutathione-regulated potassium exporter activity
HZ99_RS00350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZ99_RS00380	COG0745	RESPONSE REGULATOR receiver
HZ99_RS00395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ99_RS00405	COG3718	enzyme involved in inositol metabolism
HZ99_RS00410	COG3962	Belongs to the TPP enzyme family
HZ99_RS00415	COG0673	inositol 2-dehydrogenase activity
HZ99_RS00420	COG0673	inositol 2-dehydrogenase activity
HZ99_RS00430	COG1129	ABC transporter
HZ99_RS00435	COG4211	Belongs to the binding-protein-dependent transport system permease family
HZ99_RS00480	COG4774	siderophore transport
HZ99_RS00495	COG1320	monovalent cation:proton antiporter activity
HZ99_RS00500	COG2212	antiporter activity
HZ99_RS00505	COG1863	multisubunit Na H antiporter MnhE subunit
HZ99_RS00510	COG0651	ATP synthesis coupled electron transport
HZ99_RS00515	COG1006	Multisubunit Na H antiporter MnhC subunit
HZ99_RS00520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZ99_RS00520	COG2111	Na H antiporter
HZ99_RS00540	COG0667	Aldo Keto reductase
HZ99_RS00550	COG0477	Major facilitator Superfamily
HZ99_RS00570	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS00580	COG4948	Mandelate Racemase Muconate Lactonizing
HZ99_RS00600	COG0019	diaminopimelate decarboxylase activity
HZ99_RS00615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZ99_RS00620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ99_RS00625	COG1064	alcohol dehydrogenase
HZ99_RS00675	COG1522	sequence-specific DNA binding
HZ99_RS00685	COG0583	DNA-binding transcription factor activity
HZ99_RS00725	COG0154	amidase activity
HZ99_RS00730	COG2271	Major facilitator Superfamily
HZ99_RS00750	COG2814	Major facilitator Superfamily
HZ99_RS00780	COG0019	diaminopimelate decarboxylase activity
HZ99_RS00785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZ99_RS00800	COG0625	glutathione transferase activity
HZ99_RS00835	COG2205	protein histidine kinase activity
HZ99_RS00840	COG0596	Alpha beta hydrolase
HZ99_RS00855	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS00895	COG1999	signal sequence binding
HZ99_RS00930	COG2267	carboxylic ester hydrolase activity
HZ99_RS00935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS00955	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS00970	COG0183	Belongs to the thiolase family
HZ99_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS00980	COG0673	inositol 2-dehydrogenase activity
HZ99_RS01010	COG2706	6-phosphogluconolactonase activity
HZ99_RS01030	COG0420	3'-5' exonuclease activity
HZ99_RS01060	COG0714	Associated with various cellular activities
HZ99_RS01090	COG2818	Glycosylase
HZ99_RS01105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZ99_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS01120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ99_RS01130	COG0814	amino acid
HZ99_RS01165	COG0589	response to stress
HZ99_RS01175	COG0745	RESPONSE REGULATOR receiver
HZ99_RS01180	COG2205	protein histidine kinase activity
HZ99_RS01195	COG2271	Major facilitator Superfamily
HZ99_RS01430	COG3179	chitinase
HZ99_RS01575	COG3179	chitinase
HZ99_RS01585	COG1846	Transcriptional regulator
HZ99_RS01595	COG0583	DNA-binding transcription factor activity
HZ99_RS01605	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS01630	COG0640	Transcriptional regulator
HZ99_RS01645	COG0642	Histidine kinase
HZ99_RS01705	COG1629	transport
HZ99_RS01705	COG4774	siderophore transport
HZ99_RS01715	COG3121	Chaperone
HZ99_RS01720	COG3188	usher protein
HZ99_RS01730	COG3706	GGDEF domain
HZ99_RS01730	COG2203	Gaf domain
HZ99_RS01730	COG4251	negative regulation of phosphorylation
HZ99_RS01730	COG5001	Diguanylate cyclase
HZ99_RS01735	COG2197	response regulator
HZ99_RS01760	COG3706	GGDEF domain
HZ99_RS01765	COG0784	Response regulator, receiver
HZ99_RS01765	COG4191	Histidine kinase
HZ99_RS01775	COG0477	Major facilitator Superfamily
HZ99_RS01780	COG0579	oxidoreductase
HZ99_RS01785	COG2186	Transcriptional regulator
HZ99_RS01790	COG0477	Major facilitator Superfamily
HZ99_RS01795	COG0583	DNA-binding transcription factor activity
HZ99_RS01810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZ99_RS01815	COG3318	Belongs to the UPF0149 family
HZ99_RS01815	COG3012	SEC-C Motif Domain Protein
HZ99_RS01825	COG1595	DNA-templated transcription, initiation
HZ99_RS01835	COG0730	response to heat
HZ99_RS01860	COG0583	DNA-binding transcription factor activity
HZ99_RS01875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ99_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ99_RS01890	COG3256	nitric oxide reductase
HZ99_RS01910	COG3604	Transcriptional regulator
HZ99_RS01920	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZ99_RS01930	COG0826	peptidase U32
HZ99_RS01935	COG0826	peptidase U32
HZ99_RS01940	COG3154	lipid carrier protein
HZ99_RS01965	COG0697	spore germination
HZ99_RS01970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS01975	COG3039	Transposase
HZ99_RS01995	COG1595	DNA-templated transcription, initiation
HZ99_RS02005	COG0493	'glutamate synthase
HZ99_RS02010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZ99_RS02020	COG3192	ethanolamine utilization protein
HZ99_RS02035	COG0625	glutathione transferase activity
HZ99_RS02045	COG1595	DNA-templated transcription, initiation
HZ99_RS02050	COG3712	iron ion homeostasis
HZ99_RS02055	COG4772	TonB-dependent receptor
HZ99_RS02115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HZ99_RS02135	COG0488	(ABC) transporter
HZ99_RS02145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZ99_RS02170	COG2169	Transcriptional regulator
HZ99_RS02170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZ99_RS02175	COG3145	DNA-N1-methyladenine dioxygenase activity
HZ99_RS02190	COG2863	cytochrome
HZ99_RS02195	COG3258	Cytochrome c
HZ99_RS02265	COG2200	EAL domain
HZ99_RS02270	COG0583	DNA-binding transcription factor activity
HZ99_RS02275	COG0697	spore germination
HZ99_RS02295	COG1522	sequence-specific DNA binding
HZ99_RS02300	COG0667	Aldo Keto reductase
HZ99_RS02310	COG4172	Belongs to the ABC transporter superfamily
HZ99_RS02315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ99_RS02350	COG2271	Major facilitator Superfamily
HZ99_RS02355	COG3835	regulator
HZ99_RS02360	COG1929	Belongs to the glycerate kinase type-1 family
HZ99_RS02365	COG1247	-acetyltransferase
HZ99_RS02370	COG1794	racemase activity, acting on amino acids and derivatives
HZ99_RS02380	COG3278	Belongs to the heme-copper respiratory oxidase family
HZ99_RS02385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ99_RS02410	COG3119	arylsulfatase activity
HZ99_RS02425	COG2304	oxidoreductase activity
HZ99_RS02445	COG0714	Associated with various cellular activities
HZ99_RS02480	COG0745	RESPONSE REGULATOR receiver
HZ99_RS02485	COG0784	Response regulator, receiver
HZ99_RS02485	COG2198	Histidine kinase
HZ99_RS02485	COG2205	protein histidine kinase activity
HZ99_RS02490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZ99_RS02500	COG0784	Response regulator, receiver
HZ99_RS02500	COG2205	protein histidine kinase activity
HZ99_RS02520	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HZ99_RS02530	COG3781	membrane
HZ99_RS02535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ99_RS02550	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS02555	COG1024	Enoyl-CoA hydratase
HZ99_RS02570	COG2366	antibiotic biosynthetic process
HZ99_RS02585	COG0840	transmembrane signaling receptor activity
HZ99_RS02590	COG1968	undecaprenyl-diphosphatase activity
HZ99_RS02605	COG0583	DNA-binding transcription factor activity
HZ99_RS02610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZ99_RS02625	COG0488	(ABC) transporter
HZ99_RS02655	COG2133	pyrroloquinoline quinone binding
HZ99_RS02670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ99_RS02695	COG2822	iron ion transport
HZ99_RS02700	COG0672	)-iron permease
HZ99_RS02705	COG2207	Transcriptional regulator
HZ99_RS02720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS02730	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS02740	COG0463	Glycosyl transferase, family 2
HZ99_RS02750	COG1971	Probably functions as a manganese efflux pump
HZ99_RS02755	COG0642	Histidine kinase
HZ99_RS02795	COG2207	Transcriptional regulator
HZ99_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS02820	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HZ99_RS02835	COG2814	Major facilitator Superfamily
HZ99_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS02855	COG3321	synthase
HZ99_RS02855	COG0604	alcohol dehydrogenase
HZ99_RS02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS02880	COG0210	DNA helicase
HZ99_RS02895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS02915	COG1113	amino acid transport
HZ99_RS02960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZ99_RS02975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZ99_RS02975	COG1199	ATP-dependent helicase activity
HZ99_RS02980	COG2267	carboxylic ester hydrolase activity
HZ99_RS02995	COG2308	Evidence 4 Homologs of previously reported genes of
HZ99_RS03005	COG1522	sequence-specific DNA binding
HZ99_RS03015	COG0826	peptidase U32
HZ99_RS03025	COG1113	amino acid transport
HZ99_RS03035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ99_RS03040	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ99_RS03055	COG3483	tryptophan 2,3-dioxygenase activity
HZ99_RS03065	COG1522	sequence-specific DNA binding
HZ99_RS03095	COG2433	Pfam Transposase IS66
HZ99_RS03130	COG4974	Belongs to the 'phage' integrase family
HZ99_RS03150	COG3384	dioxygenase
HZ99_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS03185	COG0583	DNA-binding transcription factor activity
HZ99_RS03190	COG1942	4-Oxalocrotonate Tautomerase
HZ99_RS03200	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS03210	COG1024	Enoyl-CoA hydratase
HZ99_RS03215	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS03250	COG3344	reverse transcriptase
HZ99_RS03270	COG1802	Transcriptional regulator
HZ99_RS03280	COG0579	oxidoreductase
HZ99_RS03285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZ99_RS03300	COG0411	ABC transporter
HZ99_RS03325	COG1566	PFAM secretion protein HlyD family protein
HZ99_RS03350	COG2814	Major facilitator Superfamily
HZ99_RS03370	COG2116	formate transmembrane transporter activity
HZ99_RS03375	COG0753	catalase activity
HZ99_RS03385	COG4772	TonB-dependent receptor
HZ99_RS03395	COG4264	IucA IucC family
HZ99_RS03410	COG0019	diaminopimelate decarboxylase activity
HZ99_RS03415	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZ99_RS03440	COG3121	Chaperone
HZ99_RS03455	COG5001	Diguanylate cyclase
HZ99_RS03455	COG3300	MHYT domain
HZ99_RS03465	COG2197	response regulator
HZ99_RS03475	COG3121	Chaperone
HZ99_RS03485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZ99_RS03495	COG0463	Glycosyl transferase, family 2
HZ99_RS03505	COG0726	polysaccharide deacetylase
HZ99_RS03510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZ99_RS03515	COG2076	Multidrug Resistance protein
HZ99_RS03520	COG2076	Multidrug Resistance protein
HZ99_RS03545	COG1024	Enoyl-CoA hydratase
HZ99_RS03550	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS03565	COG1238	metal cluster binding
HZ99_RS03570	COG0596	Alpha beta hydrolase
HZ99_RS03625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZ99_RS03630	COG0297	glycogen (starch) synthase activity
HZ99_RS03635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZ99_RS03640	COG1640	4-alpha-glucanotransferase
HZ99_RS03665	COG3468	outer membrane autotransporter barrel domain protein
HZ99_RS03670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HZ99_RS03690	COG0348	domain, Protein
HZ99_RS03695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS03705	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS03715	COG1538	Outer membrane efflux protein
HZ99_RS03755	COG1175	transmembrane transport
HZ99_RS03775	COG1070	Carbohydrate kinase
HZ99_RS03785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZ99_RS03795	COG4574	serine-type endopeptidase inhibitor activity
HZ99_RS03805	COG0024	Methionine aminopeptidase
HZ99_RS03810	COG0598	Magnesium transport protein CorA
HZ99_RS03815	COG0189	ligase activity
HZ99_RS03825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ99_RS03835	COG2816	NAD+ diphosphatase activity
HZ99_RS03840	COG1024	Enoyl-CoA hydratase
HZ99_RS03845	COG2205	protein histidine kinase activity
HZ99_RS03850	COG0745	RESPONSE REGULATOR receiver
HZ99_RS03860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS03895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ99_RS03910	COG2233	PERMEase
HZ99_RS03980	COG2204	response regulator
HZ99_RS03990	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZ99_RS03995	COG0561	phosphatase activity
HZ99_RS04000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZ99_RS04005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HZ99_RS04010	COG2194	sulfuric ester hydrolase activity
HZ99_RS04015	COG0583	DNA-binding transcription factor activity
HZ99_RS04035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HZ99_RS04050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZ99_RS04055	COG0308	aminopeptidase N
HZ99_RS04065	COG3139	Protein of unknown function (DUF1315)
HZ99_RS04070	COG0705	Rhomboid family
HZ99_RS04075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZ99_RS04080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZ99_RS04130	COG0316	Belongs to the HesB IscA family
HZ99_RS04130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZ99_RS04160	COG1879	ABC-type sugar transport system periplasmic component
HZ99_RS04175	COG0431	NADPH-dependent FMN reductase
HZ99_RS04200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZ99_RS04215	COG0328	RNA-DNA hybrid ribonuclease activity
HZ99_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ99_RS04230	COG1388	LysM domain
HZ99_RS04230	COG0741	lytic transglycosylase activity
HZ99_RS04235	COG4166	transmembrane transport
HZ99_RS04240	COG4166	transmembrane transport
HZ99_RS04245	COG4174	ABC transporter (Permease)
HZ99_RS04250	COG4239	(ABC) transporter, permease
HZ99_RS04255	COG4172	Belongs to the ABC transporter superfamily
HZ99_RS04270	COG0494	nUDIX hydrolase
HZ99_RS04275	COG3706	GGDEF domain
HZ99_RS04300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ99_RS04300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ99_RS04315	COG2181	nitrate reductase activity
HZ99_RS04320	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HZ99_RS04325	COG1140	nitrate reductase beta subunit
HZ99_RS04330	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HZ99_RS04335	COG2223	nitrite transmembrane transporter activity
HZ99_RS04345	COG3850	Histidine kinase
HZ99_RS04350	COG2197	response regulator
HZ99_RS04355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ99_RS04370	COG2271	Major facilitator Superfamily
HZ99_RS04375	COG4948	Mandelate Racemase Muconate Lactonizing
HZ99_RS04385	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS04395	COG3254	rhamnose metabolic process
HZ99_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS04410	COG3829	transcription factor binding
HZ99_RS04450	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS04470	COG1136	(ABC) transporter
HZ99_RS04470	COG0577	efflux transmembrane transporter activity
HZ99_RS04475	COG0577	efflux transmembrane transporter activity
HZ99_RS04475	COG1136	(ABC) transporter
HZ99_RS04485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS04490	COG0156	8-amino-7-oxononanoate synthase activity
HZ99_RS04530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZ99_RS04535	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS04540	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS04545	COG0640	Transcriptional regulator
HZ99_RS04565	COG3300	MHYT domain
HZ99_RS04565	COG5001	Diguanylate cyclase
HZ99_RS04570	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS04580	COG1473	amidohydrolase
HZ99_RS04600	COG0583	DNA-binding transcription factor activity
HZ99_RS04635	COG2165	general secretion pathway protein
HZ99_RS04645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ99_RS04675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ99_RS04680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ99_RS04700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZ99_RS04710	COG4335	DNA alkylation repair
HZ99_RS04720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZ99_RS04725	COG0154	amidase activity
HZ99_RS04730	COG0475	glutathione-regulated potassium exporter activity
HZ99_RS04740	COG1566	PFAM secretion protein HlyD family protein
HZ99_RS04755	COG1335	isochorismatase
HZ99_RS04760	COG1335	isochorismatase
HZ99_RS04765	COG0583	DNA-binding transcription factor activity
HZ99_RS04780	COG1511	domain protein
HZ99_RS04780	COG3264	Mechanosensitive ion channel
HZ99_RS04785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ99_RS04785	COG1024	Enoyl-CoA hydratase
HZ99_RS04795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS04820	COG2130	NADP-dependent
HZ99_RS04935	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS04940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ99_RS04955	COG2072	flavoprotein involved in K transport
HZ99_RS04975	COG0322	excinuclease ABC activity
HZ99_RS04980	COG2197	response regulator
HZ99_RS05000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZ99_RS05005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ99_RS05010	COG4166	transmembrane transport
HZ99_RS05015	COG4174	ABC transporter (Permease)
HZ99_RS05020	COG4239	(ABC) transporter, permease
HZ99_RS05025	COG4172	Belongs to the ABC transporter superfamily
HZ99_RS05030	COG3290	protein histidine kinase activity
HZ99_RS05030	COG3829	transcription factor binding
HZ99_RS05035	COG2610	gluconate transmembrane transporter activity
HZ99_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS05045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ99_RS05055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ99_RS05060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ99_RS05080	COG3118	belongs to the thioredoxin family
HZ99_RS05085	COG1253	flavin adenine dinucleotide binding
HZ99_RS05095	COG0698	ribose 5-phosphate isomerase
HZ99_RS05100	COG1129	ABC transporter
HZ99_RS05105	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ99_RS05110	COG1879	ABC-type sugar transport system periplasmic component
HZ99_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS05120	COG1063	alcohol dehydrogenase
HZ99_RS05125	COG2376	Dihydroxyacetone kinase
HZ99_RS05135	COG0616	signal peptide processing
HZ99_RS05150	COG5383	Protein conserved in bacteria
HZ99_RS05160	COG4191	Histidine kinase
HZ99_RS05160	COG0784	Response regulator, receiver
HZ99_RS05165	COG0587	DNA-directed DNA polymerase activity
HZ99_RS05180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZ99_RS05185	COG0673	inositol 2-dehydrogenase activity
HZ99_RS05230	COG0531	amino acid
HZ99_RS05235	COG3938	Belongs to the proline racemase family
HZ99_RS05240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZ99_RS05250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS05285	COG0583	DNA-binding transcription factor activity
HZ99_RS05290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ99_RS05290	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS05365	COG2433	Pfam Transposase IS66
HZ99_RS05375	COG3039	Transposase
HZ99_RS05380	COG2175	clavaminate synthase activity
HZ99_RS05390	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HZ99_RS05450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZ99_RS05455	COG0435	Glutathione S-transferase
HZ99_RS05460	COG1648	precorrin-2 dehydrogenase activity
HZ99_RS05460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZ99_RS05465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZ99_RS05470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZ99_RS05475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZ99_RS05480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZ99_RS05485	COG1674	ftsk spoiiie
HZ99_RS05490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HZ99_RS05495	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZ99_RS05500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZ99_RS05505	COG0542	response to heat
HZ99_RS05510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HZ99_RS05515	COG1278	Cold shock
HZ99_RS05530	COG0583	DNA-binding transcription factor activity
HZ99_RS05540	COG3039	Transposase
HZ99_RS05545	COG4670	ketone body catabolic process
HZ99_RS05550	COG0697	spore germination
HZ99_RS05560	COG0482	sulfurtransferase activity
HZ99_RS05565	COG2915	High frequency lysogenization protein hflD homolog
HZ99_RS05575	COG2850	peptidyl-arginine hydroxylation
HZ99_RS05580	COG2153	protein acetylation
HZ99_RS05595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ99_RS05600	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ99_RS05605	COG0649	NAD binding
HZ99_RS05605	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ99_RS05620	COG1034	ATP synthesis coupled electron transport
HZ99_RS05625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZ99_RS05630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZ99_RS05640	COG0713	ATP synthesis coupled electron transport
HZ99_RS05655	COG1007	ATP synthesis coupled electron transport
HZ99_RS05670	COG0395	ABC-type sugar transport system, permease component
HZ99_RS05680	COG3842	ATPase activity
HZ99_RS05685	COG3842	ATPase activity
HZ99_RS05690	COG3284	Transcriptional regulator
HZ99_RS05710	COG0215	cysteine-tRNA ligase activity
HZ99_RS05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ99_RS05725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ99_RS05730	COG2814	Major facilitator Superfamily
HZ99_RS05735	COG1566	PFAM secretion protein HlyD family protein
HZ99_RS05740	COG1846	Transcriptional regulator
HZ99_RS05745	COG2911	Protein conserved in bacteria
HZ99_RS05750	COG0729	surface antigen
HZ99_RS05760	COG0708	Exodeoxyribonuclease III
HZ99_RS05765	COG2885	chlorophyll binding
HZ99_RS05770	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS05780	COG0789	Transcriptional regulator
HZ99_RS05790	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS05795	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS05800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZ99_RS05825	COG2866	Carboxypeptidase
HZ99_RS05840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZ99_RS05850	COG0217	transcriptional regulatory protein
HZ99_RS05865	COG0583	DNA-binding transcription factor activity
HZ99_RS05870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZ99_RS05875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ99_RS05880	COG3038	cytochrome b561
HZ99_RS05890	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS05890	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ99_RS05910	COG1846	Transcriptional regulator
HZ99_RS05915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZ99_RS05930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ99_RS05935	COG0776	regulation of translation
HZ99_RS05940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZ99_RS05945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZ99_RS05950	COG0740	serine-type endopeptidase activity
HZ99_RS05955	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZ99_RS05960	COG3344	reverse transcriptase
HZ99_RS05985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZ99_RS06000	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZ99_RS06010	COG1686	Belongs to the peptidase S11 family
HZ99_RS06025	COG1953	Uracil, thiamine, allantoin
HZ99_RS06035	COG0493	'glutamate synthase
HZ99_RS06045	COG1309	transcriptional regulator
HZ99_RS06070	COG0471	metal ion transport
HZ99_RS06090	COG0730	response to heat
HZ99_RS06100	COG0640	Transcriptional regulator
HZ99_RS06110	COG1522	sequence-specific DNA binding
HZ99_RS06115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ99_RS06120	COG0022	dehydrogenase e1 component
HZ99_RS06130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ99_RS06135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ99_RS06140	COG0456	acetyltransferase
HZ99_RS06155	COG2423	ornithine cyclodeaminase activity
HZ99_RS06165	COG4215	(ABC) transporter
HZ99_RS06215	COG3237	CsbD-like
HZ99_RS06225	COG2814	Major facilitator Superfamily
HZ99_RS06240	COG0174	glutamine synthetase
HZ99_RS06245	COG4335	DNA alkylation repair
HZ99_RS06270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ99_RS06275	COG0517	IMP dehydrogenase activity
HZ99_RS06285	COG0583	DNA-binding transcription factor activity
HZ99_RS06290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZ99_RS06320	COG0113	porphobilinogen synthase activity
HZ99_RS06325	COG0384	phenazine biosynthesis protein PhzF
HZ99_RS06330	COG0625	glutathione transferase activity
HZ99_RS06340	COG0701	Predicted permease
HZ99_RS06345	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HZ99_RS06350	COG0709	Synthesizes selenophosphate from selenide and ATP
HZ99_RS06355	COG1253	flavin adenine dinucleotide binding
HZ99_RS06365	COG0583	DNA-binding transcription factor activity
HZ99_RS06375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HZ99_RS06385	COG3132	Protein of unknown function, DUF480
HZ99_RS06390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZ99_RS06410	COG0628	permease
HZ99_RS06415	COG0826	peptidase U32
HZ99_RS06425	COG2056	Na+-H+ antiporter family
HZ99_RS06430	COG0840	transmembrane signaling receptor activity
HZ99_RS06485	COG0720	synthase
HZ99_RS06500	COG1051	belongs to the nudix hydrolase family
HZ99_RS06505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZ99_RS06515	COG0402	S-adenosylhomocysteine deaminase activity
HZ99_RS06525	COG2223	nitrite transmembrane transporter activity
HZ99_RS06545	COG4772	TonB-dependent receptor
HZ99_RS06555	COG1595	DNA-templated transcription, initiation
HZ99_RS06565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS06575	COG0174	glutamine synthetase
HZ99_RS06590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZ99_RS06605	COG0583	DNA-binding transcription factor activity
HZ99_RS06610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS06625	COG3209	COG3209 Rhs family protein
HZ99_RS06625	COG3209	COG3209 Rhs family protein
HZ99_RS06630	COG3706	GGDEF domain
HZ99_RS06635	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS06645	COG0154	amidase activity
HZ99_RS06665	COG0583	DNA-binding transcription factor activity
HZ99_RS06675	COG1609	Transcriptional regulator
HZ99_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS06690	COG1063	alcohol dehydrogenase
HZ99_RS06695	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ99_RS06705	COG1879	ABC-type sugar transport system periplasmic component
HZ99_RS06725	COG0406	alpha-ribazole phosphatase activity
HZ99_RS06730	COG1522	sequence-specific DNA binding
HZ99_RS06745	COG1846	Transcriptional regulator
HZ99_RS06770	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS06775	COG3384	dioxygenase
HZ99_RS06785	COG2271	Major facilitator Superfamily
HZ99_RS06790	COG3971	2-oxopent-4-enoate hydratase activity
HZ99_RS06800	COG1846	Transcriptional regulator
HZ99_RS06805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS06825	COG0531	amino acid
HZ99_RS06840	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS06860	COG0390	transport system, permease component
HZ99_RS06865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ99_RS06900	COG3485	protocatechuate 3,4-dioxygenase
HZ99_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS06925	COG0583	DNA-binding transcription factor activity
HZ99_RS06940	COG0410	ABC transporter
HZ99_RS06945	COG1137	ATPase activity
HZ99_RS06960	COG1764	response to oxidative stress
HZ99_RS06975	COG3473	Maleate cis-trans isomerase
HZ99_RS06980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ99_RS06985	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ99_RS07010	COG2814	Major facilitator Superfamily
HZ99_RS07035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HZ99_RS07080	COG0776	regulation of translation
HZ99_RS07085	COG0072	phenylalanine-tRNA ligase activity
HZ99_RS07090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZ99_RS07095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZ99_RS07100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZ99_RS07105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZ99_RS07110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ99_RS07120	COG1278	Cold shock
HZ99_RS07145	COG1869	D-ribose catabolic process
HZ99_RS07150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ99_RS07155	COG1609	Transcriptional regulator
HZ99_RS07160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ99_RS07165	COG1129	ABC transporter
HZ99_RS07195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZ99_RS07210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ99_RS07270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS07305	COG1286	toxin biosynthetic process
HZ99_RS07310	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZ99_RS07315	COG0285	dihydrofolate synthase activity
HZ99_RS07320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZ99_RS07325	COG0135	phosphoribosylanthranilate isomerase activity
HZ99_RS07350	COG0473	3-isopropylmalate dehydrogenase activity
HZ99_RS07355	COG2226	methyltransferase
HZ99_RS07360	COG0066	3-isopropylmalate dehydratase activity
HZ99_RS07365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZ99_RS07400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ99_RS07410	COG0596	Alpha beta hydrolase
HZ99_RS07440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ99_RS07455	COG0556	nucleotide-excision repair
HZ99_RS07470	COG0583	DNA-binding transcription factor activity
HZ99_RS07475	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS07520	COG2258	MOSC domain
HZ99_RS07525	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS07530	COG2384	SAM-dependent methyltransferase
HZ99_RS07535	COG0789	Transcriptional regulator
HZ99_RS07545	COG3781	membrane
HZ99_RS07550	COG2957	Belongs to the agmatine deiminase family
HZ99_RS07565	COG2957	Belongs to the agmatine deiminase family
HZ99_RS07570	COG0583	DNA-binding transcription factor activity
HZ99_RS07590	COG0582	viral genome integration into host DNA
HZ99_RS07625	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS07630	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS07635	COG1024	Enoyl-CoA hydratase
HZ99_RS07670	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS07675	COG2814	Major facilitator Superfamily
HZ99_RS07680	COG2267	carboxylic ester hydrolase activity
HZ99_RS07685	COG2233	PERMEase
HZ99_RS07690	COG0583	DNA-binding transcription factor activity
HZ99_RS07700	COG2814	Major facilitator Superfamily
HZ99_RS07705	COG0583	DNA-binding transcription factor activity
HZ99_RS07710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ99_RS07725	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZ99_RS07730	COG1611	Belongs to the LOG family
HZ99_RS07740	COG0579	oxidoreductase
HZ99_RS07745	COG1309	transcriptional regulator
HZ99_RS07765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ99_RS07770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZ99_RS07790	COG2853	Lipoprotein
HZ99_RS07805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZ99_RS07805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZ99_RS07825	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZ99_RS07830	COG1136	(ABC) transporter
HZ99_RS07835	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZ99_RS07845	COG0584	glycerophosphoryl diester phosphodiesterase
HZ99_RS07850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ99_RS07855	COG1477	protein flavinylation
HZ99_RS07870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZ99_RS07880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ99_RS07925	COG0183	Belongs to the thiolase family
HZ99_RS07930	COG1024	Enoyl-CoA hydratase
HZ99_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS07940	COG0589	response to stress
HZ99_RS07945	COG0488	(ABC) transporter
HZ99_RS07950	COG0741	lytic transglycosylase activity
HZ99_RS07955	COG1132	(ABC) transporter
HZ99_RS07965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZ99_RS07975	COG0425	Belongs to the sulfur carrier protein TusA family
HZ99_RS07980	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HZ99_RS07995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZ99_RS08000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZ99_RS08025	COG0840	transmembrane signaling receptor activity
HZ99_RS08050	COG3278	Belongs to the heme-copper respiratory oxidase family
HZ99_RS08070	COG3278	Belongs to the heme-copper respiratory oxidase family
HZ99_RS08085	COG2010	Cytochrome c
HZ99_RS08090	COG0348	domain, Protein
HZ99_RS08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ99_RS08130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ99_RS08135	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS08140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZ99_RS08145	COG2130	NADP-dependent
HZ99_RS08150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZ99_RS08155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZ99_RS08170	COG0840	transmembrane signaling receptor activity
HZ99_RS08185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ99_RS08190	COG3115	cell septum assembly
HZ99_RS08210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZ99_RS08220	COG0402	S-adenosylhomocysteine deaminase activity
HZ99_RS08225	COG1802	Transcriptional regulator
HZ99_RS08230	COG3135	benzoate transporter
HZ99_RS08235	COG3171	Protein conserved in bacteria
HZ99_RS08250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZ99_RS08250	COG0116	Belongs to the methyltransferase superfamily
HZ99_RS08255	COG0167	dihydroorotate dehydrogenase activity
HZ99_RS08265	COG0457	Tetratricopeptide repeat
HZ99_RS08265	COG3710	Transcriptional regulator
HZ99_RS08275	COG1116	anion transmembrane transporter activity
HZ99_RS08275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ99_RS08280	COG3707	response regulator
HZ99_RS08285	COG2223	nitrite transmembrane transporter activity
HZ99_RS08295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ99_RS08300	COG2146	nitrite reductase [NAD(P)H] activity
HZ99_RS08305	COG0243	molybdopterin cofactor binding
HZ99_RS08310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZ99_RS08315	COG2885	chlorophyll binding
HZ99_RS08315	COG3047	cAMP biosynthetic process
HZ99_RS08340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZ99_RS08355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZ99_RS08360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS08385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ99_RS08395	COG2079	MmgE PrpD family protein
HZ99_RS08405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZ99_RS08410	COG0372	Belongs to the citrate synthase family
HZ99_RS08420	COG1802	Transcriptional regulator
HZ99_RS08425	COG0189	ligase activity
HZ99_RS08425	COG4067	protein conserved in archaea
HZ99_RS08435	COG0189	ligase activity
HZ99_RS08445	COG0560	Phosphoserine phosphatase
HZ99_RS08455	COG1953	Uracil, thiamine, allantoin
HZ99_RS08465	COG0583	DNA-binding transcription factor activity
HZ99_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS08475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ99_RS08620	COG4695	Portal protein
HZ99_RS08670	COG0659	secondary active sulfate transmembrane transporter activity
HZ99_RS08690	COG0598	Magnesium transport protein CorA
HZ99_RS08695	COG0519	Catalyzes the synthesis of GMP from XMP
HZ99_RS08700	COG1024	Enoyl-CoA hydratase
HZ99_RS08700	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS08705	COG0183	Belongs to the thiolase family
HZ99_RS08725	COG2308	Evidence 4 Homologs of previously reported genes of
HZ99_RS08755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS08760	COG2885	chlorophyll binding
HZ99_RS08760	COG3047	cAMP biosynthetic process
HZ99_RS08790	COG2207	Transcriptional regulator
HZ99_RS08795	COG1064	alcohol dehydrogenase
HZ99_RS08800	COG1414	Transcriptional regulator
HZ99_RS08830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZ99_RS08840	COG0084	hydrolase, TatD family'
HZ99_RS08850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZ99_RS08855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZ99_RS08865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ99_RS08870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ99_RS08885	COG0416	fatty acid biosynthetic process
HZ99_RS08890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZ99_RS08895	COG1399	metal-binding, possibly nucleic acid-binding protein
HZ99_RS08900	COG0424	maF-like protein
HZ99_RS08905	COG0616	signal peptide processing
HZ99_RS08905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZ99_RS08910	COG0546	phosphoglycolate phosphatase activity
HZ99_RS08920	COG1530	ribonuclease E activity
HZ99_RS08925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ99_RS08930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZ99_RS08930	COG3608	succinylglutamate desuccinylase aspartoacylase
HZ99_RS08945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZ99_RS08950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ99_RS08955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZ99_RS08960	COG2835	tetraacyldisaccharide 4'-kinase activity
HZ99_RS08965	COG1663	tetraacyldisaccharide 4'-kinase activity
HZ99_RS08970	COG0848	biopolymer transport protein
HZ99_RS08975	COG0811	peptide transport
HZ99_RS08980	COG2333	competence protein COMEC
HZ99_RS08980	COG0658	competence protein
HZ99_RS08990	COG0784	Response regulator, receiver
HZ99_RS08990	COG2205	protein histidine kinase activity
HZ99_RS08990	COG5002	protein histidine kinase activity
HZ99_RS08995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ99_RS09010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ99_RS09015	COG1393	Belongs to the ArsC family
HZ99_RS09035	COG0037	tRNA processing
HZ99_RS09045	COG3091	SprT-like family
HZ99_RS09050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZ99_RS09055	COG1301	dicarboxylic acid transport
HZ99_RS09060	COG4977	sequence-specific DNA binding
HZ99_RS09060	COG1917	Cupin 2, conserved barrel domain protein
HZ99_RS09080	COG2205	protein histidine kinase activity
HZ99_RS09085	COG0745	RESPONSE REGULATOR receiver
HZ99_RS09115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZ99_RS09130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HZ99_RS09170	COG2433	Pfam Transposase IS66
HZ99_RS09190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZ99_RS09195	COG1558	bacterial-type flagellum-dependent cell motility
HZ99_RS09200	COG1815	bacterial-type flagellum-dependent cell motility
HZ99_RS09205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZ99_RS09210	COG0835	chemotaxis
HZ99_RS09210	COG0784	Response regulator, receiver
HZ99_RS09230	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HZ99_RS09235	COG0477	Major facilitator Superfamily
HZ99_RS09240	COG1368	sulfuric ester hydrolase activity
HZ99_RS09255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZ99_RS09265	COG0463	Glycosyl transferase, family 2
HZ99_RS09285	COG3842	ATPase activity
HZ99_RS09290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ99_RS09295	COG0463	Glycosyl transferase, family 2
HZ99_RS09300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ99_RS09300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ99_RS09305	COG0726	polysaccharide deacetylase
HZ99_RS09310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZ99_RS09315	COG2076	Multidrug Resistance protein
HZ99_RS09320	COG2076	Multidrug Resistance protein
HZ99_RS09365	COG0642	Histidine kinase
HZ99_RS09375	COG3039	Transposase
HZ99_RS09390	COG3039	Transposase
HZ99_RS09495	COG3047	cAMP biosynthetic process
HZ99_RS09495	COG2885	chlorophyll binding
HZ99_RS09560	COG2239	Acts as a magnesium transporter
HZ99_RS09580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZ99_RS09585	COG0527	aspartate kinase activity
HZ99_RS09590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ99_RS09595	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HZ99_RS09600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZ99_RS09605	COG2988	succinylglutamate desuccinylase activity
HZ99_RS09615	COG3724	N-succinylarginine dihydrolase activity
HZ99_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS09635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ99_RS09665	COG4215	(ABC) transporter
HZ99_RS09670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS09675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ99_RS09685	COG3039	Transposase
HZ99_RS09690	COG2207	Transcriptional regulator
HZ99_RS09690	COG1917	Cupin 2, conserved barrel domain protein
HZ99_RS09700	COG1653	transport
HZ99_RS09705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ99_RS09740	COG3706	GGDEF domain
HZ99_RS09755	COG0584	glycerophosphoryl diester phosphodiesterase
HZ99_RS09775	COG0306	phosphate transporter
HZ99_RS09780	COG1984	allophanate hydrolase subunit 2
HZ99_RS09790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZ99_RS09800	COG0583	DNA-binding transcription factor activity
HZ99_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS09815	COG0583	DNA-binding transcription factor activity
HZ99_RS09820	COG4941	Belongs to the sigma-70 factor family
HZ99_RS09830	COG3795	YCII-related domain
HZ99_RS09860	COG0436	Aminotransferase
HZ99_RS09870	COG3265	gluconokinase activity
HZ99_RS09875	COG1609	Transcriptional regulator
HZ99_RS09885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZ99_RS09905	COG0242	peptide deformylase activity
HZ99_RS09910	COG1295	ribonuclease BN
HZ99_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS09930	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS09935	COG2267	carboxylic ester hydrolase activity
HZ99_RS09940	COG2030	dehydratase
HZ99_RS09950	COG3530	Putative quorum-sensing-regulated virulence factor
HZ99_RS09955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ99_RS09960	COG0800	Aldolase
HZ99_RS09975	COG1737	Transcriptional regulator
HZ99_RS09980	COG0676	glucose-6-phosphate 1-epimerase activity
HZ99_RS09995	COG0395	ABC-type sugar transport system, permease component
HZ99_RS10000	COG1175	transmembrane transport
HZ99_RS10005	COG1653	transport
HZ99_RS10010	COG2942	2-epimerase
HZ99_RS10020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ99_RS10025	COG0583	DNA-binding transcription factor activity
HZ99_RS10040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZ99_RS10060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ99_RS10110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZ99_RS10120	COG0009	L-threonylcarbamoyladenylate synthase
HZ99_RS10130	COG2917	probably involved in intracellular septation
HZ99_RS10135	COG2350	Protein conserved in bacteria
HZ99_RS10145	COG0745	RESPONSE REGULATOR receiver
HZ99_RS10155	COG0642	Histidine kinase
HZ99_RS10160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZ99_RS10180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZ99_RS10205	COG0509	glycine decarboxylation via glycine cleavage system
HZ99_RS10210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZ99_RS10210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZ99_RS10215	COG1760	l-serine dehydratase
HZ99_RS10220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZ99_RS10225	COG1278	Cold shock
HZ99_RS10235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZ99_RS10240	COG0583	DNA-binding transcription factor activity
HZ99_RS10245	COG1304	FMN binding
HZ99_RS10250	COG5654	RES domain protein
HZ99_RS10275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZ99_RS10280	COG0602	queuosine metabolic process
HZ99_RS10285	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HZ99_RS10290	COG2885	chlorophyll binding
HZ99_RS10295	COG0823	Involved in the tonB-independent uptake of proteins
HZ99_RS10315	COG0824	Thioesterase
HZ99_RS10320	COG2255	four-way junction helicase activity
HZ99_RS10325	COG0632	four-way junction helicase activity
HZ99_RS10330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZ99_RS10335	COG0217	transcriptional regulatory protein
HZ99_RS10340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZ99_RS10355	COG0783	Belongs to the Dps family
HZ99_RS10365	COG2900	Belongs to the SlyX family
HZ99_RS10380	COG3039	Transposase
HZ99_RS10385	COG0668	transmembrane transport
HZ99_RS10390	COG1666	GTP binding
HZ99_RS10400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS10400	COG4191	Histidine kinase
HZ99_RS10405	COG2096	Adenosyltransferase
HZ99_RS10415	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZ99_RS10420	COG0653	protein targeting
HZ99_RS10430	COG0433	COG0433 Predicted ATPase
HZ99_RS10445	COG0788	formyltetrahydrofolate deformylase activity
HZ99_RS10455	COG2925	Exonuclease
HZ99_RS10485	COG0714	Associated with various cellular activities
HZ99_RS10505	COG0469	pyruvate kinase activity
HZ99_RS10510	COG1024	Enoyl-CoA hydratase
HZ99_RS10525	COG4191	Histidine kinase
HZ99_RS10535	COG0477	Major facilitator Superfamily
HZ99_RS10545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZ99_RS10560	COG2207	Transcriptional regulator
HZ99_RS10595	COG3712	iron ion homeostasis
HZ99_RS10610	COG2832	Protein of unknown function (DUF454)
HZ99_RS10615	COG0840	transmembrane signaling receptor activity
HZ99_RS10640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS10645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS10650	COG5001	Diguanylate cyclase
HZ99_RS10650	COG2203	Gaf domain
HZ99_RS10650	COG3706	GGDEF domain
HZ99_RS10650	COG4251	negative regulation of phosphorylation
HZ99_RS10655	COG2201	protein-glutamate methylesterase activity
HZ99_RS10670	COG0457	Tetratricopeptide repeat
HZ99_RS10670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZ99_RS10695	COG3642	lipopolysaccharide core region biosynthetic process
HZ99_RS10705	COG0642	Histidine kinase
HZ99_RS10715	COG1368	sulfuric ester hydrolase activity
HZ99_RS10720	COG0459	protein refolding
HZ99_RS10725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZ99_RS10740	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS10750	COG3695	enzyme binding
HZ99_RS10755	COG2211	Major facilitator Superfamily
HZ99_RS10760	COG0442	prolyl-tRNA aminoacylation
HZ99_RS10770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ99_RS10795	COG3158	transport of potassium into the cell
HZ99_RS10800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ99_RS10815	COG4807	Protein conserved in bacteria
HZ99_RS10830	COG0583	DNA-binding transcription factor activity
HZ99_RS10845	COG3148	PFAM DTW domain containing protein
HZ99_RS10860	COG2137	regulation of response to DNA damage stimulus
HZ99_RS10870	COG1546	Belongs to the CinA family
HZ99_RS10880	COG3179	chitinase
HZ99_RS10975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZ99_RS10985	COG0489	protein tyrosine kinase activity
HZ99_RS10990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ99_RS10990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ99_RS10995	COG4657	Part of a membrane complex involved in electron transport
HZ99_RS11000	COG2878	Part of a membrane complex involved in electron transport
HZ99_RS11005	COG4658	electron transport chain
HZ99_RS11010	COG4659	FMN binding
HZ99_RS11020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZ99_RS11030	COG2197	response regulator
HZ99_RS11035	COG0137	argininosuccinate synthase activity
HZ99_RS11045	COG0418	dihydroorotase activity
HZ99_RS11050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZ99_RS11055	COG0450	alkyl hydroperoxide reductase
HZ99_RS11070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZ99_RS11075	COG0243	molybdopterin cofactor binding
HZ99_RS11080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZ99_RS11085	COG3842	ATPase activity
HZ99_RS11090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZ99_RS11100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZ99_RS11115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS11120	COG0765	amino acid transport
HZ99_RS11125	COG0765	amino acid transport
HZ99_RS11130	COG1126	abc transporter atp-binding protein
HZ99_RS11150	COG2204	response regulator
HZ99_RS11155	COG4191	Histidine kinase
HZ99_RS11170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ99_RS11185	COG2076	Multidrug Resistance protein
HZ99_RS11210	COG0583	DNA-binding transcription factor activity
HZ99_RS11215	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS11230	COG0254	rRNA binding
HZ99_RS11235	COG0069	glutamate synthase activity
HZ99_RS11250	COG1113	amino acid transport
HZ99_RS11290	COG1695	Transcriptional regulator
HZ99_RS11295	COG2375	cellular response to nickel ion
HZ99_RS11305	COG4628	conserved protein (DUF2132)
HZ99_RS11310	COG4206	TonB-dependent receptor
HZ99_RS11335	COG0523	cobalamin synthesis protein
HZ99_RS11370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZ99_RS11385	COG2226	methyltransferase
HZ99_RS11390	COG0500	methyltransferase
HZ99_RS11395	COG0590	tRNA wobble adenosine to inosine editing
HZ99_RS11405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZ99_RS11410	COG1381	Involved in DNA repair and RecF pathway recombination
HZ99_RS11415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZ99_RS11420	COG0571	ribonuclease III activity
HZ99_RS11425	COG0681	Belongs to the peptidase S26 family
HZ99_RS11430	COG0481	GTPase activity
HZ99_RS11435	COG0795	lipopolysaccharide-transporting ATPase activity
HZ99_RS11440	COG0795	lipopolysaccharide-transporting ATPase activity
HZ99_RS11445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZ99_RS11460	COG0525	valine-tRNA ligase activity
HZ99_RS11465	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HZ99_RS11475	COG3081	Nucleoid-associated protein
HZ99_RS11490	COG2827	Endonuclease containing a URI domain
HZ99_RS11505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS11505	COG2205	protein histidine kinase activity
HZ99_RS11515	COG3539	Fimbrial protein
HZ99_RS11530	COG3121	Chaperone
HZ99_RS11535	COG3188	usher protein
HZ99_RS11540	COG3539	Fimbrial protein
HZ99_RS11545	COG3539	Fimbrial protein
HZ99_RS11550	COG2807	transmembrane transport
HZ99_RS11555	COG2186	Transcriptional regulator
HZ99_RS11560	COG1126	abc transporter atp-binding protein
HZ99_RS11565	COG0765	amino acid transport
HZ99_RS11570	COG4597	amino acid ABC transporter
HZ99_RS11575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS11580	COG0400	carboxylic ester hydrolase activity
HZ99_RS11585	COG0513	Belongs to the DEAD box helicase family
HZ99_RS11600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZ99_RS11605	COG0315	cyclic pyranopterin monophosphate synthase activity
HZ99_RS11610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZ99_RS11620	COG3022	response to hydroperoxide
HZ99_RS11630	COG1215	transferase activity, transferring glycosyl groups
HZ99_RS11635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS11640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HZ99_RS11650	COG3420	alginic acid biosynthetic process
HZ99_RS11665	COG1696	Membrane protein involved in D-alanine export
HZ99_RS11680	COG0662	Cupin 2, conserved barrel domain protein
HZ99_RS11680	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HZ99_RS11695	COG0300	oxidoreductase activity
HZ99_RS11700	COG1566	PFAM secretion protein HlyD family protein
HZ99_RS11720	COG0583	DNA-binding transcription factor activity
HZ99_RS11725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ99_RS11730	COG0835	chemotaxis
HZ99_RS11730	COG0784	Response regulator, receiver
HZ99_RS11775	COG5002	protein histidine kinase activity
HZ99_RS11785	COG2203	Gaf domain
HZ99_RS11785	COG4251	negative regulation of phosphorylation
HZ99_RS11785	COG5001	Diguanylate cyclase
HZ99_RS11785	COG3706	GGDEF domain
HZ99_RS11790	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZ99_RS11795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZ99_RS11810	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZ99_RS11815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZ99_RS11820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ99_RS11825	COG0772	Belongs to the SEDS family
HZ99_RS11830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZ99_RS11835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ99_RS11840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ99_RS11845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZ99_RS11860	COG0275	rRNA processing
HZ99_RS11865	COG2001	Belongs to the MraZ family
HZ99_RS11880	COG0792	nuclease activity
HZ99_RS11885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZ99_RS11890	COG2823	Periplasmic or secreted lipoprotein
HZ99_RS11895	COG2885	chlorophyll binding
HZ99_RS11900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ99_RS11905	COG1944	ATP diphosphatase activity
HZ99_RS11925	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS11930	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS11935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ99_RS11940	COG2813	Specifically methylates the guanine in position
HZ99_RS11945	COG2119	membrane
HZ99_RS11950	COG0501	Belongs to the peptidase M48B family
HZ99_RS11955	COG0840	transmembrane signaling receptor activity
HZ99_RS11960	COG2135	peptidase activity
HZ99_RS12015	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZ99_RS12020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZ99_RS12030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZ99_RS12035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZ99_RS12040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZ99_RS12045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ99_RS12065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZ99_RS12070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZ99_RS12075	COG1127	ABC transporter
HZ99_RS12085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZ99_RS12095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HZ99_RS12100	COG1137	ATPase activity
HZ99_RS12105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZ99_RS12110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZ99_RS12120	COG1660	Displays ATPase and GTPase activities
HZ99_RS12155	COG0312	modulator of DNA gyrase
HZ99_RS12160	COG3028	Belongs to the UPF0307 family
HZ99_RS12165	COG0312	modulator of DNA gyrase
HZ99_RS12170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ99_RS12180	COG1530	ribonuclease E activity
HZ99_RS12185	COG0424	maF-like protein
HZ99_RS12195	COG1792	Involved in formation and maintenance of cell shape
HZ99_RS12200	COG1077	Cell shape determining protein MreB Mrl
HZ99_RS12205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ99_RS12210	COG0154	amidase activity
HZ99_RS12215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ99_RS12220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZ99_RS12230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZ99_RS12245	COG2969	positive regulation of protein catabolic process
HZ99_RS12250	COG0625	glutathione transferase activity
HZ99_RS12255	COG2857	Cytochrome c1
HZ99_RS12260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZ99_RS12265	COG0723	plastoquinol--plastocyanin reductase activity
HZ99_RS12270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZ99_RS12275	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZ99_RS12280	COG0667	Aldo Keto reductase
HZ99_RS12285	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS12295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZ99_RS12300	COG0180	Tryptophanyl-tRNA synthetase
HZ99_RS12315	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HZ99_RS12335	COG0747	negative chemotaxis
HZ99_RS12340	COG0747	negative chemotaxis
HZ99_RS12345	COG0747	negative chemotaxis
HZ99_RS12355	COG0747	negative chemotaxis
HZ99_RS12360	COG0601	transmembrane transport
HZ99_RS12365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ99_RS12370	COG0444	Belongs to the ABC transporter superfamily
HZ99_RS12375	COG4608	Belongs to the ABC transporter superfamily
HZ99_RS12390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZ99_RS12415	COG0019	diaminopimelate decarboxylase activity
HZ99_RS12425	COG3128	pkhd-type hydroxylase
HZ99_RS12430	COG4774	siderophore transport
HZ99_RS12435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZ99_RS12445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ99_RS12445	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HZ99_RS12445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ99_RS12450	COG1105	Belongs to the carbohydrate kinase PfkB family
HZ99_RS12460	COG1609	Transcriptional regulator
HZ99_RS12465	COG0084	hydrolase, TatD family'
HZ99_RS12480	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZ99_RS12525	COG0237	dephospho-CoA kinase activity
HZ99_RS12530	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HZ99_RS12560	COG1252	NADH dehydrogenase
HZ99_RS12585	COG0542	response to heat
HZ99_RS12610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS12635	COG2165	general secretion pathway protein
HZ99_RS12640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZ99_RS12645	COG1047	Peptidyl-prolyl cis-trans
HZ99_RS12650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZ99_RS12655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZ99_RS12660	COG0196	riboflavin kinase activity
HZ99_RS12665	COG0728	peptidoglycan biosynthetic process
HZ99_RS12670	COG0268	Binds directly to 16S ribosomal RNA
HZ99_RS12675	COG3045	CreA protein
HZ99_RS12680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZ99_RS12685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZ99_RS12690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZ99_RS12695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZ99_RS12700	COG0142	geranyltranstransferase activity
HZ99_RS12705	COG2824	Alkylphosphonate utilization operon protein PhnA
HZ99_RS12710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ99_RS12715	COG0545	Peptidyl-prolyl cis-trans isomerase
HZ99_RS12720	COG2862	Uncharacterized protein family, UPF0114
HZ99_RS12735	COG1067	ATP-dependent peptidase activity
HZ99_RS12765	COG0488	(ABC) transporter
HZ99_RS12775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZ99_RS12780	COG0523	cobalamin synthesis protein
HZ99_RS12785	COG2879	small protein
HZ99_RS12790	COG1966	Carbon starvation protein
HZ99_RS12815	COG1970	mechanosensitive ion channel activity
HZ99_RS12825	COG2197	response regulator
HZ99_RS12830	COG2813	Specifically methylates the guanine in position
HZ99_RS12835	COG1294	oxidase, subunit
HZ99_RS12840	COG1271	oxidase subunit
HZ99_RS12855	COG2252	PERMEase
HZ99_RS12860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ99_RS12865	COG4206	TonB-dependent receptor
HZ99_RS12865	COG1629	transport
HZ99_RS12880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZ99_RS12885	COG1309	transcriptional regulator
HZ99_RS12890	COG1082	Xylose isomerase domain protein TIM barrel
HZ99_RS12890	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HZ99_RS12910	COG2321	neutral zinc metallopeptidase
HZ99_RS12925	COG1946	Acyl-CoA thioesterase
HZ99_RS12935	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZ99_RS12940	COG2081	HI0933 family
HZ99_RS12945	COG0513	Belongs to the DEAD box helicase family
HZ99_RS12950	COG0697	spore germination
HZ99_RS12955	COG1522	sequence-specific DNA binding
HZ99_RS12960	COG1199	ATP-dependent helicase activity
HZ99_RS12960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZ99_RS12970	COG3416	Protein conserved in bacteria
HZ99_RS13050	COG1061	Type III restriction enzyme res subunit
HZ99_RS13065	COG3039	Transposase
HZ99_RS13085	COG1643	Atp-dependent helicase
HZ99_RS13095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZ99_RS13105	COG1522	sequence-specific DNA binding
HZ99_RS13120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZ99_RS13125	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS13130	COG2198	Histidine kinase
HZ99_RS13130	COG0784	Response regulator, receiver
HZ99_RS13130	COG2205	protein histidine kinase activity
HZ99_RS13140	COG0352	thiamine-phosphate diphosphorylase activity
HZ99_RS13145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZ99_RS13160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ99_RS13165	COG1702	phosphate starvation-inducible protein PhoH
HZ99_RS13170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZ99_RS13175	COG4535	Mg2 and Co2 transporter CorC
HZ99_RS13180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZ99_RS13195	COG0495	leucyl-tRNA aminoacylation
HZ99_RS13215	COG2951	lytic endotransglycosylase activity
HZ99_RS13220	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZ99_RS13225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZ99_RS13230	COG0321	lipoyl(octanoyl) transferase activity
HZ99_RS13235	COG2921	Belongs to the UPF0250 family
HZ99_RS13240	COG1686	Belongs to the peptidase S11 family
HZ99_RS13250	COG2951	lytic endotransglycosylase activity
HZ99_RS13255	COG0772	Belongs to the SEDS family
HZ99_RS13260	COG0768	penicillin binding
HZ99_RS13265	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZ99_RS13275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZ99_RS13280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZ99_RS13285	COG2094	Belongs to the DNA glycosylase MPG family
HZ99_RS13290	COG0586	Pfam SNARE associated Golgi protein
HZ99_RS13305	COG1346	cytolysis
HZ99_RS13310	COG1380	Effector of murein hydrolase LrgA
HZ99_RS13325	COG0702	epimerase
HZ99_RS13340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZ99_RS13350	COG3284	Transcriptional regulator
HZ99_RS13360	COG0531	amino acid
HZ99_RS13365	COG4303	Ethanolamine ammonia lyase large subunit
HZ99_RS13370	COG4302	ethanolamine ammonia-lyase activity
HZ99_RS13375	COG0456	acetyltransferase
HZ99_RS13380	COG0586	Pfam SNARE associated Golgi protein
HZ99_RS13390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZ99_RS13400	COG0582	viral genome integration into host DNA
HZ99_RS13410	COG4983	Phage plasmid primase, P4 family domain protein
HZ99_RS13440	COG0640	Transcriptional regulator
HZ99_RS13445	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS13445	COG3321	synthase
HZ99_RS13445	COG0604	alcohol dehydrogenase
HZ99_RS13450	COG1309	transcriptional regulator
HZ99_RS13455	COG1979	alcohol dehydrogenase
HZ99_RS13470	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS13480	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS13485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ99_RS13495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ99_RS13500	COG3039	Transposase
HZ99_RS13505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZ99_RS13515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZ99_RS13520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZ99_RS13520	COG2010	Cytochrome c
HZ99_RS13535	COG2130	NADP-dependent
HZ99_RS13540	COG1309	transcriptional regulator
HZ99_RS13550	COG2963	transposase activity
HZ99_RS13555	COG2801	Transposase and inactivated derivatives
HZ99_RS13595	COG5377	YqaJ viral recombinase family
HZ99_RS13605	COG2003	Belongs to the UPF0758 family
HZ99_RS13620	COG0443	Heat shock 70 kDa protein
HZ99_RS13730	COG1070	Carbohydrate kinase
HZ99_RS13750	COG1722	exodeoxyribonuclease VII activity
HZ99_RS13755	COG0142	geranyltranstransferase activity
HZ99_RS13760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ99_RS13765	COG4206	TonB-dependent receptor
HZ99_RS13770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ99_RS13780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ99_RS13790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZ99_RS13795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ99_RS13800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZ99_RS13815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ99_RS13815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ99_RS13820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ99_RS13830	COG2264	protein methyltransferase activity
HZ99_RS13835	COG3118	belongs to the thioredoxin family
HZ99_RS13875	COG3047	cAMP biosynthetic process
HZ99_RS13890	COG2207	Transcriptional regulator
HZ99_RS13890	COG4753	response regulator
HZ99_RS13895	COG1335	isochorismatase
HZ99_RS13900	COG4106	trans-aconitate 2-methyltransferase activity
HZ99_RS13915	COG2963	transposase activity
HZ99_RS13920	COG2801	Transposase and inactivated derivatives
HZ99_RS13935	COG0629	single-stranded DNA binding
HZ99_RS13940	COG2814	Major facilitator Superfamily
HZ99_RS13945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZ99_RS13950	COG2193	ferroxidase activity
HZ99_RS13960	COG0203	ribosomal protein L17
HZ99_RS13965	COG0202	RNA polymerase activity
HZ99_RS13970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZ99_RS13975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZ99_RS13980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZ99_RS13990	COG0200	Binds to the 23S rRNA
HZ99_RS13995	COG1841	ribosomal large subunit assembly
HZ99_RS14000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZ99_RS14005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZ99_RS14010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZ99_RS14015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZ99_RS14020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZ99_RS14025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZ99_RS14030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZ99_RS14035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZ99_RS14040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZ99_RS14045	COG0255	Belongs to the universal ribosomal protein uL29 family
HZ99_RS14050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZ99_RS14055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZ99_RS14060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZ99_RS14065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZ99_RS14070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZ99_RS14075	COG0089	rRNA binding
HZ99_RS14080	COG0088	Forms part of the polypeptide exit tunnel
HZ99_RS14085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZ99_RS14090	COG0051	transcription antitermination factor activity, RNA binding
HZ99_RS14095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZ99_RS14100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZ99_RS14105	COG0049	tRNA binding
HZ99_RS14110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZ99_RS14115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZ99_RS14120	COG0085	RNA polymerase activity
HZ99_RS14125	COG0222	ribosome binding
HZ99_RS14130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZ99_RS14135	COG0081	regulation of translation
HZ99_RS14140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZ99_RS14180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZ99_RS14215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZ99_RS14220	COG0739	heme binding
HZ99_RS14225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HZ99_RS14230	COG0316	Belongs to the HesB IscA family
HZ99_RS14235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZ99_RS14240	COG1981	membrane
HZ99_RS14255	COG4221	oxidoreductase activity
HZ99_RS14260	COG0537	adenosine 5'-monophosphoramidase activity
HZ99_RS14265	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HZ99_RS14270	COG1765	OsmC-like protein
HZ99_RS14285	COG0134	indole-3-glycerol-phosphate synthase activity
HZ99_RS14290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZ99_RS14295	COG0512	Glutamine amidotransferase of anthranilate synthase
HZ99_RS14305	COG3240	lipase activity
HZ99_RS14305	COG4625	pathogenesis
HZ99_RS14315	COG0546	phosphoglycolate phosphatase activity
HZ99_RS14325	COG1454	alcohol dehydrogenase
HZ99_RS14335	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ99_RS14345	COG3842	ATPase activity
HZ99_RS14350	COG2197	response regulator
HZ99_RS14370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZ99_RS14375	COG3178	'Phosphotransferase
HZ99_RS14380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZ99_RS14385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ99_RS14390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZ99_RS14395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZ99_RS14400	COG2967	ApaG domain
HZ99_RS14405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZ99_RS14410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ99_RS14415	COG2766	serine protein kinase
HZ99_RS14420	COG2718	Belongs to the UPF0229 family
HZ99_RS14425	COG2719	SpoVR family
HZ99_RS14430	COG0617	tRNA 3'-terminal CCA addition
HZ99_RS14440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZ99_RS14445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZ99_RS14450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZ99_RS14460	COG0358	DNA primase activity
HZ99_RS14465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZ99_RS14500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ99_RS14555	COG2814	Major facilitator Superfamily
HZ99_RS14620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ99_RS14625	COG1335	isochorismatase
HZ99_RS14680	COG1230	cation diffusion facilitator family transporter
HZ99_RS14695	COG0431	NADPH-dependent FMN reductase
HZ99_RS14700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ99_RS14705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZ99_RS14710	COG0640	Transcriptional regulator
HZ99_RS14740	COG2433	Pfam Transposase IS66
HZ99_RS14785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ99_RS14790	COG1025	Belongs to the peptidase M16 family
HZ99_RS14800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZ99_RS14805	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HZ99_RS14815	COG0535	radical SAM domain protein
HZ99_RS14825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ99_RS14830	COG0583	DNA-binding transcription factor activity
HZ99_RS14835	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS14840	COG3706	GGDEF domain
HZ99_RS14845	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS14865	COG1073	alpha beta
HZ99_RS14865	COG2226	methyltransferase
HZ99_RS14870	COG0156	8-amino-7-oxononanoate synthase activity
HZ99_RS14875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ99_RS14880	COG1040	competence protein
HZ99_RS14885	COG3585	molybdate ion transport
HZ99_RS14885	COG2005	Transcriptional regulator
HZ99_RS14890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZ99_RS14905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZ99_RS14910	COG4566	intracellular signal transduction
HZ99_RS14910	COG0745	RESPONSE REGULATOR receiver
HZ99_RS14925	COG1595	DNA-templated transcription, initiation
HZ99_RS14930	COG3712	iron ion homeostasis
HZ99_RS14935	COG4774	siderophore transport
HZ99_RS14950	COG0625	glutathione transferase activity
HZ99_RS14955	COG4452	Inner membrane protein CreD
HZ99_RS14960	COG2205	protein histidine kinase activity
HZ99_RS14965	COG0745	RESPONSE REGULATOR receiver
HZ99_RS14970	COG4067	protein conserved in archaea
HZ99_RS14970	COG0189	ligase activity
HZ99_RS14975	COG0204	Acyl-transferase
HZ99_RS14990	COG1063	alcohol dehydrogenase
HZ99_RS15020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZ99_RS15035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZ99_RS15035	COG1017	nitric oxide dioxygenase activity
HZ99_RS15040	COG4638	Rieske (2fe-2S)
HZ99_RS15050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZ99_RS15055	COG0247	lactate metabolic process
HZ99_RS15055	COG2181	nitrate reductase activity
HZ99_RS15060	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ99_RS15060	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS15095	COG3246	L-lysine catabolic process to acetate
HZ99_RS15100	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS15120	COG1760	l-serine dehydratase
HZ99_RS15135	COG3448	diguanylate cyclase activity
HZ99_RS15135	COG4175	Glycine betaine
HZ99_RS15140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZ99_RS15145	COG1309	transcriptional regulator
HZ99_RS15150	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS15155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HZ99_RS15160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZ99_RS15170	COG0312	modulator of DNA gyrase
HZ99_RS15180	COG0477	Major facilitator Superfamily
HZ99_RS15185	COG0513	Belongs to the DEAD box helicase family
HZ99_RS15190	COG2081	HI0933 family
HZ99_RS15195	COG1289	transmembrane transporter activity
HZ99_RS15205	COG2153	protein acetylation
HZ99_RS15215	COG1451	nucleotide metabolic process
HZ99_RS15250	COG0126	phosphoglycerate kinase activity
HZ99_RS15255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZ99_RS15260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZ99_RS15265	COG0640	Transcriptional regulator
HZ99_RS15270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZ99_RS15280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ99_RS15285	COG1422	Protein of unknown function (DUF1090)
HZ99_RS15315	COG2116	formate transmembrane transporter activity
HZ99_RS15330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZ99_RS15335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZ99_RS15345	COG0513	Belongs to the DEAD box helicase family
HZ99_RS15350	COG2353	YceI-like domain
HZ99_RS15355	COG3038	cytochrome b561
HZ99_RS15365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZ99_RS15370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS15390	COG1272	protein, Hemolysin III
HZ99_RS15430	COG3052	prosthetic group binding
HZ99_RS15435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HZ99_RS15465	COG0643	Histidine kinase
HZ99_RS15465	COG2198	Histidine kinase
HZ99_RS15465	COG0784	Response regulator, receiver
HZ99_RS15490	COG0189	ligase activity
HZ99_RS15500	COG1678	Uncharacterized ACR, COG1678
HZ99_RS15505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZ99_RS15510	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZ99_RS15515	COG0540	Belongs to the ATCase OTCase family
HZ99_RS15520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZ99_RS15530	COG0791	NLP P60 protein
HZ99_RS15555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZ99_RS15560	COG2813	Specifically methylates the guanine in position
HZ99_RS15560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZ99_RS15570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZ99_RS15575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ99_RS15585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZ99_RS15590	COG2022	thiamine diphosphate biosynthetic process
HZ99_RS15600	COG2363	Small membrane protein
HZ99_RS15605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ99_RS15615	COG2177	Part of the ABC transporter FtsEX involved in
HZ99_RS15620	COG2884	Cell division ATP-binding protein ftsE
HZ99_RS15625	COG0552	protein localization to endoplasmic reticulum
HZ99_RS15630	COG0612	Peptidase, M16
HZ99_RS15635	COG0612	Peptidase, M16
HZ99_RS15640	COG0742	ribosomal rna small subunit methyltransferase
HZ99_RS15645	COG0429	hydrolase of the alpha beta-hydrolase fold
HZ99_RS15655	COG1309	transcriptional regulator
HZ99_RS15670	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HZ99_RS15675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZ99_RS15680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZ99_RS15685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZ99_RS15695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZ99_RS15700	COG0129	dihydroxy-acid dehydratase activity
HZ99_RS15710	COG1823	symporter activity
HZ99_RS15725	COG1160	GTP binding
HZ99_RS15740	COG1840	ABC-type Fe3 transport system, periplasmic component
HZ99_RS15745	COG1178	ABC-type Fe3 transport system permease component
HZ99_RS15750	COG3842	ATPase activity
HZ99_RS15755	COG0583	DNA-binding transcription factor activity
HZ99_RS15765	COG0789	Transcriptional regulator
HZ99_RS15770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZ99_RS15775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZ99_RS15785	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HZ99_RS15790	COG0494	nUDIX hydrolase
HZ99_RS15805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZ99_RS15810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZ99_RS15815	COG2234	aminopeptidase activity
HZ99_RS15820	COG3204	pilus organization
HZ99_RS15825	COG3204	pilus organization
HZ99_RS15830	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ99_RS15835	COG0277	FAD linked oxidase domain protein
HZ99_RS15840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZ99_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS15855	COG1683	Conserved Protein
HZ99_RS15895	COG1177	transmembrane transport
HZ99_RS15900	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ99_RS15905	COG3842	ATPase activity
HZ99_RS15925	COG0174	glutamine synthetase
HZ99_RS15930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZ99_RS15935	COG0174	glutamine synthetase
HZ99_RS15950	COG1116	anion transmembrane transporter activity
HZ99_RS15955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZ99_RS15960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ99_RS15965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ99_RS15970	COG0431	NADPH-dependent FMN reductase
HZ99_RS15975	COG0450	alkyl hydroperoxide reductase
HZ99_RS15985	COG4521	taurine ABC transporter
HZ99_RS15990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZ99_RS15990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZ99_RS16005	COG1522	sequence-specific DNA binding
HZ99_RS16015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ99_RS16020	COG0330	HflC and HflK could
HZ99_RS16035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ99_RS16040	COG0509	glycine decarboxylation via glycine cleavage system
HZ99_RS16045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZ99_RS16050	COG1178	ABC-type Fe3 transport system permease component
HZ99_RS16060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZ99_RS16070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZ99_RS16075	COG0006	proline dipeptidase activity
HZ99_RS16080	COG3079	Belongs to the UPF0149 family
HZ99_RS16095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZ99_RS16105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS16110	COG1129	ABC transporter
HZ99_RS16110	COG0842	Transport permease protein
HZ99_RS16115	COG0842	Transport permease protein
HZ99_RS16130	COG2271	Major facilitator Superfamily
HZ99_RS16155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZ99_RS16175	COG3188	usher protein
HZ99_RS16180	COG3121	Chaperone
HZ99_RS16190	COG0248	Ppx GppA phosphatase
HZ99_RS16195	COG0154	amidase activity
HZ99_RS16200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZ99_RS16210	COG0586	Pfam SNARE associated Golgi protein
HZ99_RS16215	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HZ99_RS16220	COG0672	)-iron permease
HZ99_RS16245	COG1280	lysine exporter protein (LysE YggA)
HZ99_RS16255	COG0488	(ABC) transporter
HZ99_RS16280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZ99_RS16300	COG0181	hydroxymethylbilane synthase activity
HZ99_RS16315	COG0165	Argininosuccinate lyase
HZ99_RS16320	COG0625	glutathione transferase activity
HZ99_RS16340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZ99_RS16350	COG1965	Belongs to the frataxin family
HZ99_RS16360	COG0019	diaminopimelate decarboxylase activity
HZ99_RS16365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZ99_RS16375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZ99_RS16380	COG1011	Hydrolase
HZ99_RS16395	COG0004	ammonium transporteR
HZ99_RS16400	COG0347	Belongs to the P(II) protein family
HZ99_RS16410	COG0606	chelatase, subunit chli
HZ99_RS16415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ99_RS16420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ99_RS16435	COG0606	chelatase, subunit chli
HZ99_RS16440	COG0840	transmembrane signaling receptor activity
HZ99_RS16445	COG0583	DNA-binding transcription factor activity
HZ99_RS16450	COG0534	Mate efflux family protein
HZ99_RS16465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ99_RS16470	COG0427	acetyl-CoA hydrolase
HZ99_RS16485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZ99_RS16490	COG0251	oxidation-reduction process
HZ99_RS16495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS16510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS16520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS16525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ99_RS16535	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS16545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ99_RS16550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZ99_RS16555	COG0747	negative chemotaxis
HZ99_RS16560	COG2003	Belongs to the UPF0758 family
HZ99_RS16565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ99_RS16570	COG0756	dUTP diphosphatase activity
HZ99_RS16575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ99_RS16580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZ99_RS16585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZ99_RS16590	COG0708	Exodeoxyribonuclease III
HZ99_RS16600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZ99_RS16605	COG1561	YicC-like family, N-terminal region
HZ99_RS16610	COG0194	GDP metabolic process
HZ99_RS16615	COG1758	RNA polymerase activity
HZ99_RS16620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZ99_RS16645	COG0848	biopolymer transport protein
HZ99_RS16655	COG0583	DNA-binding transcription factor activity
HZ99_RS16660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZ99_RS16685	COG3039	Transposase
HZ99_RS16705	COG3161	chorismate lyase activity
HZ99_RS16710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZ99_RS16730	COG1253	flavin adenine dinucleotide binding
HZ99_RS16735	COG0739	heme binding
HZ99_RS16745	COG0704	Plays a role in the regulation of phosphate uptake
HZ99_RS16750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ99_RS16755	COG0573	inorganic phosphate transmembrane transporter activity
HZ99_RS16770	COG0477	Major facilitator Superfamily
HZ99_RS16775	COG1607	acyl-coa hydrolase
HZ99_RS16805	COG0583	DNA-binding transcription factor activity
HZ99_RS16810	COG1027	Aspartate ammonia-lyase
HZ99_RS16815	COG1115	amino acid carrier protein
HZ99_RS16820	COG0252	asparaginase activity
HZ99_RS16855	COG2808	Putative FMN-binding domain
HZ99_RS16875	COG0511	ligase activity, forming carbon-carbon bonds
HZ99_RS16875	COG5016	pyruvate
HZ99_RS16880	COG0439	Biotin carboxylase
HZ99_RS16885	COG0583	DNA-binding transcription factor activity
HZ99_RS16900	COG0210	DNA helicase
HZ99_RS16940	COG4651	solute:proton antiporter activity
HZ99_RS16940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZ99_RS16945	COG1607	acyl-coa hydrolase
HZ99_RS16950	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HZ99_RS16960	COG0523	cobalamin synthesis protein
HZ99_RS16985	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ99_RS16990	COG1469	GTP cyclohydrolase I activity
HZ99_RS16995	COG1121	(ABC) transporter
HZ99_RS17005	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ99_RS17010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZ99_RS17020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZ99_RS17030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ99_RS17035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ99_RS17045	COG3220	belongs to the UPF0276 family
HZ99_RS17055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZ99_RS17060	COG2267	carboxylic ester hydrolase activity
HZ99_RS17065	COG0671	phosphoesterase, PA-phosphatase related
HZ99_RS17065	COG2453	phosphatase
HZ99_RS17080	COG4589	Belongs to the CDS family
HZ99_RS17120	COG5642	Protein of unknown function (DUF2384)
HZ99_RS17135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZ99_RS17150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS17155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS17235	COG2433	Pfam Transposase IS66
HZ99_RS17240	COG1230	cation diffusion facilitator family transporter
HZ99_RS17265	COG3081	Nucleoid-associated protein
HZ99_RS17275	COG0431	NADPH-dependent FMN reductase
HZ99_RS17280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ99_RS17285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZ99_RS17290	COG0640	Transcriptional regulator
HZ99_RS17330	COG3039	Transposase
HZ99_RS17340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ99_RS17345	COG1349	DNA-binding transcription factor activity
HZ99_RS17350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ99_RS17355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZ99_RS17360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZ99_RS17365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZ99_RS17370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZ99_RS17375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ99_RS17380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZ99_RS17390	COG0356	it plays a direct role in the translocation of protons across the membrane
HZ99_RS17395	COG3312	ion transport
HZ99_RS17400	COG1475	DNA binding
HZ99_RS17405	COG1192	Involved in chromosome partitioning
HZ99_RS17410	COG0357	Ribosomal RNA small subunit methyltransferase G
HZ99_RS17415	COG0445	tRNA wobble uridine modification
HZ99_RS17420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZ99_RS17425	COG0706	membrane insertase activity
HZ99_RS17430	COG0594	ribonuclease P activity
HZ99_RS17435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZ99_RS17440	COG0592	DNA-directed DNA polymerase activity
HZ99_RS17445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ99_RS17450	COG0187	DNA topoisomerase II activity
HZ99_RS17455	COG0745	RESPONSE REGULATOR receiver
HZ99_RS17480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZ99_RS17485	COG0751	glycine-tRNA ligase activity
HZ99_RS17490	COG0752	glycyl-tRNA synthetase alpha subunit
HZ99_RS17495	COG2818	Glycosylase
HZ99_RS17510	COG0569	domain protein
HZ99_RS17515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZ99_RS17520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ99_RS17525	COG0242	peptide deformylase activity
HZ99_RS17530	COG0758	DNA mediated transformation
HZ99_RS17535	COG0009	L-threonylcarbamoyladenylate synthase
HZ99_RS17545	COG0408	coproporphyrinogen oxidase activity
HZ99_RS17550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZ99_RS17565	COG3119	arylsulfatase activity
HZ99_RS17570	COG0583	DNA-binding transcription factor activity
HZ99_RS17580	COG3734	2-keto-3-deoxy-galactonokinase
HZ99_RS17585	COG0800	Aldolase
HZ99_RS17590	COG4948	Mandelate Racemase Muconate Lactonizing
HZ99_RS17595	COG2271	Major facilitator Superfamily
HZ99_RS17600	COG0159	tryptophan synthase activity
HZ99_RS17620	COG3360	Dodecin
HZ99_RS17630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ99_RS17635	COG1764	response to oxidative stress
HZ99_RS17660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZ99_RS17665	COG0339	signal peptide processing
HZ99_RS17705	COG0659	secondary active sulfate transmembrane transporter activity
HZ99_RS17715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZ99_RS17720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZ99_RS17725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZ99_RS17755	COG0109	protoheme IX farnesyltransferase activity
HZ99_RS17765	COG1464	Belongs to the NlpA lipoprotein family
HZ99_RS17770	COG2011	ABC-type metal ion transport system permease component
HZ99_RS17775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZ99_RS17785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ99_RS17790	COG1121	(ABC) transporter
HZ99_RS17795	COG0735	belongs to the Fur family
HZ99_RS17800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HZ99_RS17820	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZ99_RS17825	COG3245	cytochrome
HZ99_RS17835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZ99_RS17850	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZ99_RS17855	COG5002	protein histidine kinase activity
HZ99_RS17860	COG2204	response regulator
HZ99_RS17880	COG1301	dicarboxylic acid transport
HZ99_RS17885	COG0700	Nucleoside recognition
HZ99_RS17900	COG1127	ABC transporter
HZ99_RS17905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZ99_RS17915	COG0612	Peptidase, M16
HZ99_RS17920	COG1283	sodium-dependent phosphate transmembrane transporter activity
HZ99_RS17925	COG0861	Integral membrane protein TerC family
HZ99_RS17930	COG2851	Citrate transporter
HZ99_RS17960	COG0427	acetyl-CoA hydrolase
HZ99_RS17980	COG0583	DNA-binding transcription factor activity
HZ99_RS17985	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS17990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZ99_RS18025	COG0840	transmembrane signaling receptor activity
HZ99_RS18050	COG1802	Transcriptional regulator
HZ99_RS18060	COG5001	Diguanylate cyclase
HZ99_RS18060	COG3300	MHYT domain
HZ99_RS18075	COG1538	Outer membrane efflux protein
HZ99_RS18080	COG2274	protein secretion by the type I secretion system
HZ99_RS18085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS18090	COG2175	clavaminate synthase activity
HZ99_RS18105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZ99_RS18130	COG1595	DNA-templated transcription, initiation
HZ99_RS18140	COG4774	siderophore transport
HZ99_RS18165	COG1289	transmembrane transporter activity
HZ99_RS18175	COG1566	PFAM secretion protein HlyD family protein
HZ99_RS18190	COG5339	Protein conserved in bacteria
HZ99_RS18195	COG0457	Tetratricopeptide repeat
HZ99_RS18200	COG0726	polysaccharide deacetylase
HZ99_RS18200	COG1649	PFAM Uncharacterised BCR, COG1649
HZ99_RS18205	COG1215	transferase activity, transferring glycosyl groups
HZ99_RS18220	COG3210	domain, Protein
HZ99_RS18260	COG2304	oxidoreductase activity
HZ99_RS18265	COG1595	DNA-templated transcription, initiation
HZ99_RS18305	COG1401	restriction endodeoxyribonuclease activity
HZ99_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS18365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZ99_RS18370	COG0745	RESPONSE REGULATOR receiver
HZ99_RS18375	COG2199	diguanylate cyclase activity
HZ99_RS18395	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZ99_RS18405	COG4208	sulfate ABC transporter
HZ99_RS18410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZ99_RS18435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZ99_RS18440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ99_RS18465	COG4771	TonB-dependent receptor
HZ99_RS18470	COG2807	transmembrane transport
HZ99_RS18475	COG0590	tRNA wobble adenosine to inosine editing
HZ99_RS18480	COG0583	DNA-binding transcription factor activity
HZ99_RS18515	COG0765	amino acid transport
HZ99_RS18520	COG0765	amino acid transport
HZ99_RS18525	COG1126	abc transporter atp-binding protein
HZ99_RS18565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS18575	COG2011	ABC-type metal ion transport system permease component
HZ99_RS18580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZ99_RS18610	COG4804	nuclease activity
HZ99_RS18630	COG3621	Patatin-like phospholipase
HZ99_RS18645	COG2003	Belongs to the UPF0758 family
HZ99_RS18670	COG5489	Protein of unknown function (DUF736)
HZ99_RS18675	COG1396	sequence-specific DNA binding
HZ99_RS18700	COG1192	Involved in chromosome partitioning
HZ99_RS18715	COG4959	Type IV secretory pathway protease TraF
HZ99_RS18725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZ99_RS18735	COG2814	Major facilitator Superfamily
HZ99_RS18760	COG0640	Transcriptional regulator
HZ99_RS18765	COG1230	cation diffusion facilitator family transporter
HZ99_RS18770	COG1937	Protein conserved in bacteria
HZ99_RS18775	COG2814	Major facilitator Superfamily
HZ99_RS18780	COG0640	Transcriptional regulator
HZ99_RS18790	COG0789	Transcriptional regulator
HZ99_RS18795	COG0633	Ferredoxin
HZ99_RS18810	COG1522	sequence-specific DNA binding
HZ99_RS18815	COG0583	DNA-binding transcription factor activity
HZ99_RS18835	COG4962	Type ii secretion system protein e
HZ99_RS18840	COG3838	Conjugal transfer protein Trbc
HZ99_RS18850	COG3451	type IV secretory pathway VirB4
HZ99_RS18865	COG3846	protein secretion by the type IV secretion system
HZ99_RS18900	COG1126	abc transporter atp-binding protein
HZ99_RS18905	COG0765	amino acid transport
HZ99_RS18910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS18920	COG1045	serine acetyltransferase
HZ99_RS18925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZ99_RS18930	COG2175	clavaminate synthase activity
HZ99_RS18935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZ99_RS18940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HZ99_RS18945	COG4521	taurine ABC transporter
HZ99_RS18950	COG2918	glutathione biosynthetic process
HZ99_RS18960	COG2183	response to ionizing radiation
HZ99_RS18970	COG2205	protein histidine kinase activity
HZ99_RS18975	COG0189	ligase activity
HZ99_RS18980	COG4067	protein conserved in archaea
HZ99_RS18980	COG0189	ligase activity
HZ99_RS18985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZ99_RS18995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZ99_RS19000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HZ99_RS19020	COG0514	ATP-dependent DNA helicase (RecQ)
HZ99_RS19025	COG0824	Thioesterase
HZ99_RS19035	COG0243	molybdopterin cofactor binding
HZ99_RS19040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZ99_RS19050	COG1652	LysM domain
HZ99_RS19055	COG1011	Hydrolase
HZ99_RS19060	COG0494	nUDIX hydrolase
HZ99_RS19065	COG1218	3'(2'),5'-bisphosphate nucleotidase
HZ99_RS19090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZ99_RS19100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZ99_RS19110	COG2957	Belongs to the agmatine deiminase family
HZ99_RS19125	COG3039	Transposase
HZ99_RS19160	COG2207	Transcriptional regulator
HZ99_RS19200	COG0582	viral genome integration into host DNA
HZ99_RS19270	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HZ99_RS19275	COG1194	a g-specific adenine glycosylase
HZ99_RS19285	COG2223	nitrite transmembrane transporter activity
HZ99_RS19290	COG0131	Imidazoleglycerol-phosphate dehydratase
HZ99_RS19295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZ99_RS19305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZ99_RS19310	COG0107	imidazoleglycerol-phosphate synthase activity
HZ99_RS19330	COG2861	carbohydrate metabolic process
HZ99_RS19335	COG0793	Belongs to the peptidase S41A family
HZ99_RS19340	COG4942	peptidase
HZ99_RS19345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZ99_RS19350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ99_RS19360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZ99_RS19380	COG3852	Histidine kinase
HZ99_RS19390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ99_RS19390	COG0301	tRNA thio-modification
HZ99_RS19395	COG1217	gtp-binding protein TYPA
HZ99_RS19405	COG0058	SHG alpha-glucan phosphorylase activity
HZ99_RS19420	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HZ99_RS19440	COG0402	S-adenosylhomocysteine deaminase activity
HZ99_RS19445	COG2188	Transcriptional regulator
HZ99_RS19455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZ99_RS19460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZ99_RS19470	COG4176	ABC-type proline glycine betaine transport system permease component
HZ99_RS19475	COG0517	IMP dehydrogenase activity
HZ99_RS19475	COG4175	Glycine betaine
HZ99_RS19480	COG2986	histidine ammonia-lyase
HZ99_RS19485	COG2986	histidine ammonia-lyase
HZ99_RS19490	COG1113	amino acid transport
HZ99_RS19495	COG1228	amidohydrolase
HZ99_RS19510	COG1490	D-aminoacyl-tRNA deacylase activity
HZ99_RS19515	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HZ99_RS19520	COG2943	transferase activity, transferring hexosyl groups
HZ99_RS19530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS19535	COG0765	amino acid transport
HZ99_RS19540	COG1126	abc transporter atp-binding protein
HZ99_RS19545	COG0840	transmembrane signaling receptor activity
HZ99_RS19550	COG0840	transmembrane signaling receptor activity
HZ99_RS19565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ99_RS19570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ99_RS19575	COG0140	phosphoribosyl-ATP diphosphatase activity
HZ99_RS19580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZ99_RS19585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZ99_RS19595	COG2226	methyltransferase
HZ99_RS19620	COG3188	usher protein
HZ99_RS19625	COG3121	Chaperone
HZ99_RS19630	COG3121	Chaperone
HZ99_RS19650	COG1301	dicarboxylic acid transport
HZ99_RS19655	COG1309	transcriptional regulator
HZ99_RS19680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZ99_RS19685	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZ99_RS19695	COG0018	arginyl-trna synthetase
HZ99_RS19700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZ99_RS19705	COG0254	rRNA binding
HZ99_RS19715	COG0281	malic enzyme
HZ99_RS19750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZ99_RS19755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZ99_RS19765	COG0067	glutamate synthase
HZ99_RS19765	COG0069	glutamate synthase activity
HZ99_RS19765	COG0070	glutamate synthase
HZ99_RS19770	COG0493	'glutamate synthase
HZ99_RS19775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZ99_RS19780	COG2814	Major facilitator Superfamily
HZ99_RS19785	COG0583	DNA-binding transcription factor activity
HZ99_RS19795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ99_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS19810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ99_RS19820	COG2226	methyltransferase
HZ99_RS19845	COG2986	histidine ammonia-lyase
HZ99_RS19860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ99_RS19870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ99_RS19890	COG1192	Involved in chromosome partitioning
HZ99_RS19895	COG3118	belongs to the thioredoxin family
HZ99_RS19900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZ99_RS19905	COG1196	nuclear chromosome segregation
HZ99_RS19905	COG3264	Mechanosensitive ion channel
HZ99_RS19910	COG3263	regulation of cellular component size
HZ99_RS19930	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS19935	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZ99_RS19935	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZ99_RS19935	COG0506	proline dehydrogenase activity
HZ99_RS19940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ99_RS19945	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZ99_RS19950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ99_RS19970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZ99_RS19975	COG0859	PFAM glycosyl transferase family 9
HZ99_RS19980	COG0859	PFAM glycosyl transferase family 9
HZ99_RS19985	COG0438	transferase activity, transferring glycosyl groups
HZ99_RS19995	COG3642	lipopolysaccharide core region biosynthetic process
HZ99_RS20015	COG2192	nodulation
HZ99_RS20020	COG1215	transferase activity, transferring glycosyl groups
HZ99_RS20035	COG1132	(ABC) transporter
HZ99_RS20040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZ99_RS20040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZ99_RS20045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ99_RS20055	COG0667	Aldo Keto reductase
HZ99_RS20070	COG0583	DNA-binding transcription factor activity
HZ99_RS20075	COG1519	Transferase
HZ99_RS20080	COG1538	Outer membrane efflux protein
HZ99_RS20085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZ99_RS20095	COG0494	nUDIX hydrolase
HZ99_RS20105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZ99_RS20110	COG3150	esterase
HZ99_RS20145	COG3830	Belongs to the UPF0237 family
HZ99_RS20145	COG0560	Phosphoserine phosphatase
HZ99_RS20150	COG0688	phosphatidylethanolamine metabolic process
HZ99_RS20175	COG1162	GTPase activity
HZ99_RS20180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HZ99_RS20185	COG2860	membrane
HZ99_RS20195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZ99_RS20195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZ99_RS20200	COG0802	atpase or kinase
HZ99_RS20205	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ99_RS20210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZ99_RS20215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZ99_RS20220	COG1923	regulation of RNA biosynthetic process
HZ99_RS20225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZ99_RS20230	COG0330	HflC and HflK could
HZ99_RS20235	COG0330	HflC and HflK could
HZ99_RS20240	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HZ99_RS20245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZ99_RS20255	COG1178	ABC-type Fe3 transport system permease component
HZ99_RS20260	COG1840	ABC-type Fe3 transport system, periplasmic component
HZ99_RS20275	COG0557	exoribonuclease II activity
HZ99_RS20280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZ99_RS20285	COG0360	Binds together with S18 to 16S ribosomal RNA
HZ99_RS20290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZ99_RS20300	COG0359	binds to the 23S rRNA
HZ99_RS20305	COG0305	Participates in initiation and elongation during chromosome replication
HZ99_RS20310	COG1032	radical SAM domain protein
HZ99_RS20320	COG2308	Evidence 4 Homologs of previously reported genes of
HZ99_RS20320	COG2307	Protein conserved in bacteria
HZ99_RS20335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZ99_RS20340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZ99_RS20345	COG0583	DNA-binding transcription factor activity
HZ99_RS20350	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS20355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS20385	COG4221	oxidoreductase activity
HZ99_RS20405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZ99_RS20410	COG0830	nickel cation binding
HZ99_RS20415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HZ99_RS20420	COG0791	NLP P60 protein
HZ99_RS20425	COG1309	transcriptional regulator
HZ99_RS20435	COG2982	Protein involved in outer membrane biogenesis
HZ99_RS20440	COG0783	Belongs to the Dps family
HZ99_RS20445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HZ99_RS20450	COG0697	spore germination
HZ99_RS20470	COG0443	Heat shock 70 kDa protein
HZ99_RS20480	COG0484	heat shock protein binding
HZ99_RS20490	COG0804	urea catabolic process
HZ99_RS20495	COG0832	Belongs to the urease beta subunit family
HZ99_RS20510	COG0831	urea catabolic process
HZ99_RS20515	COG0829	nickel cation binding
HZ99_RS20525	COG0411	ABC transporter
HZ99_RS20540	COG0683	leucine binding
HZ99_RS20545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ99_RS20555	COG1120	ATPase activity
HZ99_RS20600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ99_RS20625	COG2095	MarC family integral membrane protein
HZ99_RS20635	COG0151	Belongs to the GarS family
HZ99_RS20640	COG0138	bifunctional purine biosynthesis protein purh
HZ99_RS20650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ99_RS20660	COG2264	protein methyltransferase activity
HZ99_RS20675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZ99_RS20700	COG0023	Translation Initiation Factor
HZ99_RS20705	COG1166	arginine decarboxylase activity
HZ99_RS20710	COG0534	Mate efflux family protein
HZ99_RS20715	COG2373	Large extracellular alpha-helical protein
HZ99_RS20725	COG4953	penicillin-binding protein 1C
HZ99_RS20735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZ99_RS20805	COG4964	Belongs to the GSP D family
HZ99_RS20850	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS20870	COG2217	Heavy metal translocating P-type atpase
HZ99_RS20885	COG2814	Major facilitator Superfamily
HZ99_RS20895	COG0604	alcohol dehydrogenase
HZ99_RS20900	COG0583	DNA-binding transcription factor activity
HZ99_RS20910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HZ99_RS20915	COG0387	Pfam Sodium calcium exchanger
HZ99_RS20935	COG1309	transcriptional regulator
HZ99_RS20940	COG2233	PERMEase
HZ99_RS20985	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HZ99_RS20990	COG1074	ATP-dependent DNA helicase activity
HZ99_RS20995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ99_RS21045	COG3039	Transposase
HZ99_RS21115	COG4680	protein conserved in bacteria
HZ99_RS21120	COG5499	transcription regulator containing HTH domain
HZ99_RS21125	COG2801	Transposase and inactivated derivatives
HZ99_RS21130	COG2963	transposase activity
HZ99_RS21135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZ99_RS21155	COG1131	(ABC) transporter
HZ99_RS21165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ99_RS21195	COG0789	Transcriptional regulator
HZ99_RS21205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ99_RS21250	COG3657	addiction module killer protein
HZ99_RS21255	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ99_RS21285	COG4644	lycopene metabolic process
HZ99_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS21315	COG3604	Transcriptional regulator
HZ99_RS21340	COG0640	Transcriptional regulator
HZ99_RS21375	COG3039	Transposase
HZ99_RS21380	COG1002	Type II restriction enzyme, methylase subunits
HZ99_RS21385	COG1061	Type III restriction enzyme res subunit
HZ99_RS21390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZ99_RS21415	COG3041	Addiction module toxin RelE StbE family
HZ99_RS21420	COG3077	Addiction module antitoxin, RelB DinJ family
HZ99_RS21430	COG0789	Transcriptional regulator
HZ99_RS21455	COG4644	lycopene metabolic process
HZ99_RS21495	COG1475	DNA binding
HZ99_RS21515	COG3039	Transposase
HZ99_RS21525	COG1695	Transcriptional regulator
HZ99_RS21530	COG0659	secondary active sulfate transmembrane transporter activity
HZ99_RS21535	COG0589	response to stress
HZ99_RS21570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ99_RS21595	COG3039	Transposase
HZ99_RS21600	COG0732	type I restriction modification DNA specificity domain
HZ99_RS21625	COG0582	viral genome integration into host DNA
HZ99_RS21640	COG1620	l-lactate permease
HZ99_RS21645	COG2186	Transcriptional regulator
HZ99_RS21650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZ99_RS21660	COG2914	Belongs to the UPF0125 (RnfH) family
HZ99_RS21665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZ99_RS21670	COG0735	belongs to the Fur family
HZ99_RS21675	COG0497	DNA recombination
HZ99_RS21680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZ99_RS21685	COG0443	Heat shock 70 kDa protein
HZ99_RS21690	COG0484	heat shock protein binding
HZ99_RS21695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZ99_RS21700	COG0505	Belongs to the CarA family
HZ99_RS21705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZ99_RS21710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZ99_RS21725	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HZ99_RS21730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ99_RS21735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZ99_RS21740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ99_RS21745	COG0149	triose-phosphate isomerase activity
HZ99_RS21750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZ99_RS21765	COG0779	Required for maturation of 30S ribosomal subunits
HZ99_RS21770	COG0195	Participates in both transcription termination and antitermination
HZ99_RS21775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZ99_RS21780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZ99_RS21785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZ99_RS21790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZ99_RS21795	COG1185	polyribonucleotide nucleotidyltransferase activity
HZ99_RS21800	COG2823	Periplasmic or secreted lipoprotein
HZ99_RS21810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZ99_RS21820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ99_RS21825	COG0166	Belongs to the GPI family
HZ99_RS21830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZ99_RS21835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZ99_RS21855	COG4191	Histidine kinase
HZ99_RS21865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ99_RS21875	COG0436	Aminotransferase
HZ99_RS21880	COG1489	DNA binding
HZ99_RS21890	COG4558	Periplasmic binding protein
HZ99_RS21895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ99_RS21900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HZ99_RS21920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ99_RS21930	COG3098	single-species biofilm formation
HZ99_RS21935	COG0028	Belongs to the TPP enzyme family
HZ99_RS21945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZ99_RS21950	COG1183	phosphatidylcholine synthase activity
HZ99_RS21955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZ99_RS21960	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HZ99_RS21990	COG2995	paraquat-inducible protein a
HZ99_RS21995	COG2995	paraquat-inducible protein a
HZ99_RS22000	COG3008	intermembrane lipid transfer
HZ99_RS22025	COG0456	acetyltransferase
HZ99_RS22030	COG0288	reversible hydration of carbon dioxide
HZ99_RS22045	COG2031	fatty acid transporter
HZ99_RS22115	COG2207	Transcriptional regulator
HZ99_RS22125	COG0405	Gamma-glutamyltransferase
HZ99_RS22130	COG4771	TonB-dependent receptor
HZ99_RS22150	COG0531	amino acid
HZ99_RS22160	COG2223	nitrite transmembrane transporter activity
HZ99_RS22200	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZ99_RS22210	COG4794	Type iii secretion
HZ99_RS22220	COG4792	protein secretion
HZ99_RS22255	COG4669	(LipO)protein
HZ99_RS22265	COG0012	GTP binding
HZ99_RS22270	COG0193	aminoacyl-tRNA hydrolase activity
HZ99_RS22275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZ99_RS22280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZ99_RS22290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZ99_RS22295	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HZ99_RS22305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZ99_RS22310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZ99_RS22320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZ99_RS22325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZ99_RS22340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ99_RS22350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HZ99_RS22355	COG4221	oxidoreductase activity
HZ99_RS22365	COG0415	Belongs to the DNA photolyase family
HZ99_RS22370	COG0789	Transcriptional regulator
HZ99_RS22385	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HZ99_RS22390	COG1090	epimerase
HZ99_RS22410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ99_RS22420	COG0175	sulfate reduction
HZ99_RS22430	COG0204	Acyl-transferase
HZ99_RS22435	COG0280	phosphate acetyltransferase
HZ99_RS22435	COG0857	belongs to the CobB CobQ family
HZ99_RS22445	COG1047	Peptidyl-prolyl cis-trans
HZ99_RS22450	COG0386	Belongs to the glutathione peroxidase family
HZ99_RS22465	COG1858	cytochrome C peroxidase
HZ99_RS22470	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HZ99_RS22475	COG0492	ferredoxin-NADP+ reductase activity
HZ99_RS22490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZ99_RS22505	COG0789	Transcriptional regulator
HZ99_RS22515	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ99_RS22535	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS22555	COG2909	trisaccharide binding
HZ99_RS22565	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZ99_RS22570	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ99_RS22590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ99_RS22610	COG0814	amino acid
HZ99_RS22615	COG1760	l-serine dehydratase
HZ99_RS22620	COG0583	DNA-binding transcription factor activity
HZ99_RS22630	COG4772	TonB-dependent receptor
HZ99_RS22635	COG3712	iron ion homeostasis
HZ99_RS22640	COG1595	DNA-templated transcription, initiation
HZ99_RS22670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZ99_RS22675	COG4774	siderophore transport
HZ99_RS22680	COG2027	D-alanyl-D-alanine carboxypeptidase
HZ99_RS22685	COG2207	Transcriptional regulator
HZ99_RS22690	COG0697	spore germination
HZ99_RS22695	COG3604	Transcriptional regulator
HZ99_RS22700	COG1017	nitric oxide dioxygenase activity
HZ99_RS22700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZ99_RS22705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZ99_RS22710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZ99_RS22715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZ99_RS22720	COG1845	cytochrome c oxidase, subunit III
HZ99_RS22730	COG0109	protoheme IX farnesyltransferase activity
HZ99_RS22805	COG4251	negative regulation of phosphorylation
HZ99_RS22815	COG0745	RESPONSE REGULATOR receiver
HZ99_RS22850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ99_RS22865	COG0534	Mate efflux family protein
HZ99_RS22890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZ99_RS22895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ99_RS22895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ99_RS22945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ99_RS22950	COG0601	transmembrane transport
HZ99_RS22965	COG4172	Belongs to the ABC transporter superfamily
HZ99_RS22975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZ99_RS22980	COG0343	queuine tRNA-ribosyltransferase activity
HZ99_RS22985	COG1862	Preprotein translocase
HZ99_RS23000	COG3134	Outer membrane lipoprotein
HZ99_RS23015	COG1045	serine acetyltransferase
HZ99_RS23025	COG1104	cysteine desulfurase activity
HZ99_RS23035	COG0316	Belongs to the HesB IscA family
HZ99_RS23040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HZ99_RS23045	COG0443	Heat shock 70 kDa protein
HZ99_RS23050	COG0633	Ferredoxin
HZ99_RS23060	COG0105	UTP biosynthetic process
HZ99_RS23065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZ99_RS23075	COG1426	Protein conserved in bacteria
HZ99_RS23080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZ99_RS23085	COG0124	histidyl-tRNA synthetase
HZ99_RS23100	COG1160	GTP binding
HZ99_RS23105	COG0436	Aminotransferase
HZ99_RS23110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ99_RS23115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ99_RS23120	COG0739	heme binding
HZ99_RS23125	COG1570	exodeoxyribonuclease VII activity
HZ99_RS23130	COG0583	DNA-binding transcription factor activity
HZ99_RS23150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZ99_RS23150	COG0519	Catalyzes the synthesis of GMP from XMP
HZ99_RS23155	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ99_RS23155	COG0596	Alpha beta hydrolase
HZ99_RS23180	COG2188	Transcriptional regulator
HZ99_RS23185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ99_RS23185	COG1263	PTS System
HZ99_RS23190	COG0366	Alpha amylase catalytic
HZ99_RS23200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ99_RS23200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ99_RS23210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HZ99_RS23215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ99_RS23215	COG0047	phosphoribosylformylglycinamidine synthase activity
HZ99_RS23220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZ99_RS23230	COG1263	PTS System
HZ99_RS23230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ99_RS23230	COG2190	(PTS) system
HZ99_RS23235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ99_RS23235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ99_RS23240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ99_RS23245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZ99_RS23250	COG2188	Transcriptional regulator
HZ99_RS23265	COG0494	nUDIX hydrolase
HZ99_RS23285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HZ99_RS23290	COG0477	Major facilitator Superfamily
HZ99_RS23295	COG4536	flavin adenine dinucleotide binding
HZ99_RS23305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZ99_RS23310	COG0228	four-way junction DNA binding
HZ99_RS23315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZ99_RS23320	COG0336	Belongs to the RNA methyltransferase TrmD family
HZ99_RS23325	COG0335	large ribosomal subunit rRNA binding
HZ99_RS23330	COG1607	acyl-coa hydrolase
HZ99_RS23335	COG4974	Belongs to the 'phage' integrase family
HZ99_RS23340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZ99_RS23355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS23355	COG2205	protein histidine kinase activity
HZ99_RS23360	COG2199	diguanylate cyclase activity
HZ99_RS23360	COG2200	EAL domain
HZ99_RS23360	COG2202	Pas domain
HZ99_RS23365	COG2197	response regulator
HZ99_RS23380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZ99_RS23390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZ99_RS23395	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS23410	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HZ99_RS23420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZ99_RS23425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZ99_RS23445	COG1073	alpha beta
HZ99_RS23460	COG2885	chlorophyll binding
HZ99_RS23475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HZ99_RS23480	COG0563	adenylate kinase activity
HZ99_RS23485	COG1214	PFAM Peptidase M22, glycoprotease
HZ99_RS23495	COG1801	Protein of unknown function DUF72
HZ99_RS23510	COG0742	ribosomal rna small subunit methyltransferase
HZ99_RS23520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS23525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ99_RS23545	COG2937	Belongs to the GPAT DAPAT family
HZ99_RS23560	COG2226	methyltransferase
HZ99_RS23565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ99_RS23570	COG1215	transferase activity, transferring glycosyl groups
HZ99_RS23575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZ99_RS23580	COG2166	iron-sulfur cluster assembly
HZ99_RS23585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ99_RS23590	COG2171	N-acyltransferase activity
HZ99_RS23595	COG1393	Belongs to the ArsC family
HZ99_RS23600	COG0025	NhaP-type Na H and K H
HZ99_RS23615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HZ99_RS23620	COG0024	Methionine aminopeptidase
HZ99_RS23625	COG0052	Belongs to the universal ribosomal protein uS2 family
HZ99_RS23630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZ99_RS23635	COG0528	UMP kinase activity
HZ99_RS23640	COG0233	cytoplasmic translational termination
HZ99_RS23645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZ99_RS23655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZ99_RS23665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZ99_RS23675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ99_RS23680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ99_RS23685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ99_RS23690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ99_RS23695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZ99_RS23700	COG0587	DNA-directed DNA polymerase activity
HZ99_RS23705	COG0825	malonyl-CoA metabolic process
HZ99_RS23710	COG0037	tRNA processing
HZ99_RS23715	COG0504	CTP synthase activity
HZ99_RS23720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HZ99_RS23725	COG0148	phosphopyruvate hydratase activity
HZ99_RS23735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZ99_RS23745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HZ99_RS23750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HZ99_RS23755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZ99_RS23760	COG0585	pseudouridine synthase activity
HZ99_RS23765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HZ99_RS23770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZ99_RS23785	COG1278	Cold shock
HZ99_RS23790	COG0717	Belongs to the dCTP deaminase family
HZ99_RS23800	COG2366	antibiotic biosynthetic process
HZ99_RS23805	COG0625	glutathione transferase activity
HZ99_RS23810	COG0653	protein targeting
HZ99_RS23820	COG3012	SEC-C Motif Domain Protein
HZ99_RS23850	COG1199	ATP-dependent helicase activity
HZ99_RS23870	COG0259	pyridoxamine-phosphate oxidase activity
HZ99_RS23885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZ99_RS23895	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZ99_RS23915	COG0583	DNA-binding transcription factor activity
HZ99_RS23930	COG3220	belongs to the UPF0276 family
HZ99_RS23985	COG2271	Major facilitator Superfamily
HZ99_RS23990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ99_RS24005	COG0306	phosphate transporter
HZ99_RS24015	COG1414	Transcriptional regulator
HZ99_RS24020	COG2814	Major facilitator Superfamily
HZ99_RS24025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZ99_RS24030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZ99_RS24035	COG0183	Belongs to the thiolase family
HZ99_RS24040	COG3485	protocatechuate 3,4-dioxygenase
HZ99_RS24045	COG3485	protocatechuate 3,4-dioxygenase
HZ99_RS24050	COG0477	Major facilitator Superfamily
HZ99_RS24060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZ99_RS24065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZ99_RS24090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ99_RS24095	COG1309	transcriptional regulator
HZ99_RS24100	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS24105	COG2814	Major facilitator Superfamily
HZ99_RS24145	COG3039	Transposase
HZ99_RS24160	COG3039	Transposase
HZ99_RS24165	COG1473	amidohydrolase
HZ99_RS24175	COG0154	amidase activity
HZ99_RS24190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ99_RS24205	COG1704	LemA family
HZ99_RS24225	COG0697	spore germination
HZ99_RS24230	COG1629	transport
HZ99_RS24240	COG1595	DNA-templated transcription, initiation
HZ99_RS24245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZ99_RS24250	COG0235	Class ii aldolase
HZ99_RS24255	COG1396	sequence-specific DNA binding
HZ99_RS24265	COG1454	alcohol dehydrogenase
HZ99_RS24280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZ99_RS24285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ99_RS24290	COG2271	Major facilitator Superfamily
HZ99_RS24315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZ99_RS24325	COG2267	carboxylic ester hydrolase activity
HZ99_RS24345	COG0439	Biotin carboxylase
HZ99_RS24350	COG3665	Urea carboxylase-associated protein
HZ99_RS24360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZ99_RS24390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZ99_RS24440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZ99_RS24470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ99_RS24480	COG0425	Belongs to the sulfur carrier protein TusA family
HZ99_RS24485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZ99_RS24495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZ99_RS24500	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HZ99_RS24505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZ99_RS24510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZ99_RS24530	COG2814	Major facilitator Superfamily
HZ99_RS24535	COG1024	Enoyl-CoA hydratase
HZ99_RS24535	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS24540	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS24575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS24580	COG0183	Belongs to the thiolase family
HZ99_RS24585	COG0183	Belongs to the thiolase family
HZ99_RS24590	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS24595	COG1024	Enoyl-CoA hydratase
HZ99_RS24600	COG0583	DNA-binding transcription factor activity
HZ99_RS24635	COG2910	NAD(P)H-binding
HZ99_RS24645	COG0583	DNA-binding transcription factor activity
HZ99_RS24670	COG0174	glutamine synthetase
HZ99_RS24685	COG3100	YcgL domain-containing protein
HZ99_RS24690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZ99_RS24700	COG2983	Belongs to the UPF0260 family
HZ99_RS24735	COG1770	oligopeptidase
HZ99_RS24745	COG0121	glutamine amidotransferase
HZ99_RS24755	COG0583	DNA-binding transcription factor activity
HZ99_RS24760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZ99_RS24765	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZ99_RS24770	COG1984	allophanate hydrolase subunit 2
HZ99_RS24780	COG0542	response to heat
HZ99_RS24790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ99_RS24810	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HZ99_RS24815	COG1643	Atp-dependent helicase
HZ99_RS24825	COG1595	DNA-templated transcription, initiation
HZ99_RS24850	COG1132	(ABC) transporter
HZ99_RS24875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZ99_RS24885	COG0668	transmembrane transport
HZ99_RS24890	COG0513	Belongs to the DEAD box helicase family
HZ99_RS24900	COG2132	Multicopper oxidase
HZ99_RS24935	COG2996	Protein conserved in bacteria
HZ99_RS24940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ99_RS24985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ99_RS24990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZ99_RS24995	COG3956	TIGRFAM MazG family protein
HZ99_RS25000	COG3122	Protein conserved in bacteria
HZ99_RS25015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZ99_RS25020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZ99_RS25030	COG0628	permease
HZ99_RS25035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZ99_RS25040	COG0791	NLP P60 protein
HZ99_RS25045	COG0791	NLP P60 protein
HZ99_RS25060	COG1797	cobyrinic acid a,c-diamide synthase activity
HZ99_RS25065	COG0778	Nitroreductase
HZ99_RS25080	COG1492	cobalamin metabolic process
HZ99_RS25090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZ99_RS25100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZ99_RS25105	COG1846	Transcriptional regulator
HZ99_RS25150	COG2202	Pas domain
HZ99_RS25150	COG2205	protein histidine kinase activity
HZ99_RS25155	COG2832	Protein of unknown function (DUF454)
HZ99_RS25165	COG0514	ATP-dependent DNA helicase (RecQ)
HZ99_RS25170	COG1846	Transcriptional regulator
HZ99_RS25175	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZ99_RS25195	COG2207	Transcriptional regulator
HZ99_RS25210	COG2154	pterin-4-alpha-carbinolamine dehydratase
HZ99_RS25220	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HZ99_RS25225	COG4787	bacterial-type flagellum-dependent cell motility
HZ99_RS25235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HZ99_RS25240	COG1706	bacterial-type flagellum-dependent cell motility
HZ99_RS25265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZ99_RS25275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZ99_RS25305	COG1677	Flagellar hook-basal body complex protein FliE
HZ99_RS25430	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HZ99_RS25435	COG0784	Response regulator, receiver
HZ99_RS25435	COG2198	Histidine kinase
HZ99_RS25435	COG0643	Histidine kinase
HZ99_RS25440	COG2201	protein-glutamate methylesterase activity
HZ99_RS25445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZ99_RS25455	COG1192	Involved in chromosome partitioning
HZ99_RS25465	COG0835	chemotaxis
HZ99_RS25485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZ99_RS25495	COG4133	protoheme IX ABC transporter activity
HZ99_RS25520	COG1138	Cytochrome C-type biogenesis protein
HZ99_RS25530	COG3088	subunit of a heme lyase
HZ99_RS25535	COG4235	cytochrome complex assembly
HZ99_RS25545	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HZ99_RS25550	COG2814	Major facilitator Superfamily
HZ99_RS25560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ99_RS25570	COG0469	pyruvate kinase activity
HZ99_RS25580	COG2084	Dehydrogenase
HZ99_RS25585	COG3622	Belongs to the hyi family
HZ99_RS25590	COG3960	tartronate-semialdehyde synthase activity
HZ99_RS25610	COG2354	Protein conserved in bacteria
HZ99_RS25615	COG2853	Lipoprotein
HZ99_RS25635	COG2113	Glycine betaine
HZ99_RS25640	COG3162	membrane
HZ99_RS25645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ99_RS25660	COG2009	succinate dehydrogenase
HZ99_RS25665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HZ99_RS25670	COG1053	succinate dehydrogenase
HZ99_RS25675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZ99_RS25690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ99_RS25695	COG0045	succinate-CoA ligase (ADP-forming) activity
HZ99_RS25735	COG0326	Molecular chaperone. Has ATPase activity
HZ99_RS25745	COG1741	Belongs to the pirin family
HZ99_RS25775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ99_RS25780	COG2205	protein histidine kinase activity
HZ99_RS25780	COG5002	protein histidine kinase activity
HZ99_RS25780	COG0784	Response regulator, receiver
HZ99_RS25795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZ99_RS25805	COG2062	phosphohistidine phosphatase, SixA
HZ99_RS25810	COG1022	Amp-dependent synthetase and ligase
HZ99_RS25835	COG0628	permease
HZ99_RS25840	COG2205	protein histidine kinase activity
HZ99_RS25850	COG0284	orotidine-5'-phosphate decarboxylase activity
HZ99_RS25855	COG2130	NADP-dependent
HZ99_RS25860	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS25865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ99_RS25900	COG0778	Nitroreductase
HZ99_RS25905	COG0583	DNA-binding transcription factor activity
HZ99_RS25910	COG0583	DNA-binding transcription factor activity
HZ99_RS25920	COG2159	amidohydrolase
HZ99_RS25935	COG1012	belongs to the aldehyde dehydrogenase family
HZ99_RS25940	COG0753	catalase activity
HZ99_RS25945	COG0583	DNA-binding transcription factor activity
HZ99_RS25950	COG1902	pentaerythritol trinitrate reductase activity
HZ99_RS25955	COG1309	transcriptional regulator
HZ99_RS25980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ99_RS25995	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS26005	COG0625	glutathione transferase activity
HZ99_RS26010	COG1131	(ABC) transporter
HZ99_RS26015	COG0842	Transport permease protein
HZ99_RS26025	COG0477	Major facilitator Superfamily
HZ99_RS26030	COG2076	Multidrug Resistance protein
HZ99_RS26035	COG0385	Bile acid
HZ99_RS26040	COG2974	May be involved in recombination
HZ99_RS26060	COG3712	iron ion homeostasis
HZ99_RS26065	COG1595	DNA-templated transcription, initiation
HZ99_RS26085	COG2010	Cytochrome c
HZ99_RS26090	COG0545	Peptidyl-prolyl cis-trans isomerase
HZ99_RS26115	COG2200	EAL domain
HZ99_RS26125	COG3321	synthase
HZ99_RS26125	COG4221	oxidoreductase activity
HZ99_RS26125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ99_RS26125	COG0604	alcohol dehydrogenase
HZ99_RS26130	COG0560	Phosphoserine phosphatase
HZ99_RS26135	COG3842	ATPase activity
HZ99_RS26145	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ99_RS26165	COG0668	transmembrane transport
HZ99_RS26170	COG1362	aminopeptidase activity
HZ99_RS26175	COG0564	pseudouridine synthase activity
HZ99_RS26180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HZ99_RS26185	COG2894	cell division
HZ99_RS26190	COG0850	regulation of cytokinetic process
HZ99_RS26195	COG1560	Kdo2-lipid A biosynthetic process
HZ99_RS26210	COG2233	PERMEase
HZ99_RS26220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HZ99_RS26225	COG4266	Belongs to the allantoicase family
HZ99_RS26250	COG2252	PERMEase
HZ99_RS26260	COG0625	glutathione transferase activity
HZ99_RS26270	COG0302	gtp cyclohydrolase
HZ99_RS26285	COG2840	Smr protein MutS2
HZ99_RS26310	COG1073	alpha beta
HZ99_RS26315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZ99_RS26325	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HZ99_RS26330	COG2197	response regulator
HZ99_RS26340	COG0318	PFAM AMP-dependent synthetase and ligase
HZ99_RS26380	COG3089	Belongs to the UPF0270 family
HZ99_RS26390	COG0189	ligase activity
HZ99_RS26390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZ99_RS26395	COG0367	asparagine synthase
HZ99_RS26410	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HZ99_RS26410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ99_RS26415	COG2326	polyphosphate kinase activity
HZ99_RS26420	COG0183	Belongs to the thiolase family
HZ99_RS26425	COG0697	spore germination
HZ99_RS26430	COG0114	fumarate hydratase activity
HZ99_RS26440	COG0271	Belongs to the BolA IbaG family
HZ99_RS26445	COG1054	Belongs to the UPF0176 family
HZ99_RS26460	COG5002	protein histidine kinase activity
HZ99_RS26460	COG5001	Diguanylate cyclase
HZ99_RS26475	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS26480	COG0546	phosphoglycolate phosphatase activity
HZ99_RS26485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZ99_RS26490	COG0402	S-adenosylhomocysteine deaminase activity
HZ99_RS26495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZ99_RS26505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZ99_RS26515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZ99_RS26520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZ99_RS26525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZ99_RS26535	COG0776	regulation of translation
HZ99_RS26550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZ99_RS26570	COG2244	polysaccharide biosynthetic process
HZ99_RS26600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ99_RS26605	COG2755	lipolytic protein G-D-S-L family
HZ99_RS26605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZ99_RS26610	COG1086	Polysaccharide biosynthesis protein
HZ99_RS26620	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ99_RS26625	COG1555	photosystem II stabilization
HZ99_RS26645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZ99_RS26655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZ99_RS26660	COG2205	protein histidine kinase activity
HZ99_RS26700	COG0084	hydrolase, TatD family'
HZ99_RS26705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HZ99_RS26730	COG1129	ABC transporter
HZ99_RS26735	COG3039	Transposase
HZ99_RS26745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZ99_RS26750	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HZ99_RS26755	COG4181	ATPase activity
HZ99_RS26795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZ99_RS26805	COG0589	response to stress
HZ99_RS26830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZ99_RS26835	COG1764	response to oxidative stress
HZ99_RS26840	COG1846	Transcriptional regulator
HZ99_RS26855	COG0583	DNA-binding transcription factor activity
HZ99_RS26865	COG3214	Protein conserved in bacteria
HZ99_RS26870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HZ99_RS26890	COG3384	dioxygenase
HZ99_RS26895	COG0500	methyltransferase
HZ99_RS26900	COG0501	Belongs to the peptidase M48B family
HZ99_RS26905	COG0436	Aminotransferase
HZ99_RS26910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ99_RS26915	COG0386	Belongs to the glutathione peroxidase family
HZ99_RS26920	COG1846	Transcriptional regulator
HZ99_RS26925	COG2205	protein histidine kinase activity
HZ99_RS26925	COG5002	protein histidine kinase activity
HZ99_RS26925	COG0784	Response regulator, receiver
HZ99_RS26935	COG1956	GAF domain-containing protein
HZ99_RS26940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ99_RS26940	COG2205	protein histidine kinase activity
HZ99_RS26945	COG2197	response regulator
HZ99_RS26960	COG3287	FIST C domain
HZ99_RS26960	COG2200	EAL domain
HZ99_RS26960	COG2199	diguanylate cyclase activity
HZ99_RS26980	COG0004	ammonium transporteR
HZ99_RS27000	COG0564	pseudouridine synthase activity
HZ99_RS27010	COG0746	molybdenum cofactor guanylyltransferase activity
HZ99_RS27015	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZ99_RS27020	COG0303	'Molybdopterin
HZ99_RS27025	COG1597	lipid kinase activity
HZ99_RS27030	COG2197	response regulator
HZ99_RS27055	COG3123	guanosine phosphorylase activity
HZ99_RS27070	COG1024	Enoyl-CoA hydratase
HZ99_RS27075	COG1960	acyl-CoA dehydrogenase activity
HZ99_RS27080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZ99_RS27085	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS27145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ99_RS27150	COG4232	protein-disulfide reductase activity
HZ99_RS27185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ99_RS27190	COG1121	(ABC) transporter
HZ99_RS27230	COG3829	transcription factor binding
HZ99_RS27240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ99_RS27265	COG1028	Short-chain dehydrogenase reductase Sdr
HZ99_RS27270	COG1309	transcriptional regulator
HZ99_RS27280	COG5006	permease, DMT superfamily
HZ99_RS27370	COG0582	viral genome integration into host DNA
HZ99_RS27395	COG0732	type I restriction modification DNA specificity domain
HZ99_RS27405	COG2207	Transcriptional regulator
HZ99_RS27445	COG3475	LICD family