locus-tag	class	description
X969_RS00015	COG0438	transferase activity, transferring glycosyl groups
X969_RS00055	COG4774	siderophore transport
X969_RS00060	COG3712	iron ion homeostasis
X969_RS00065	COG1595	DNA-templated transcription, initiation
X969_RS00070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X969_RS00080	COG2204	response regulator
X969_RS00085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
X969_RS00105	COG3585	molybdate ion transport
X969_RS00105	COG2005	Transcriptional regulator
X969_RS00110	COG1040	competence protein
X969_RS00115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
X969_RS00120	COG0156	8-amino-7-oxononanoate synthase activity
X969_RS00145	COG1960	acyl-CoA dehydrogenase activity
X969_RS00150	COG3706	GGDEF domain
X969_RS00155	COG1960	acyl-CoA dehydrogenase activity
X969_RS00160	COG0583	DNA-binding transcription factor activity
X969_RS00165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X969_RS00180	COG0535	radical SAM domain protein
X969_RS00190	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
X969_RS00195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X969_RS00200	COG1025	Belongs to the peptidase M16 family
X969_RS00205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X969_RS00235	COG3039	Transposase
X969_RS00240	COG4993	Dehydrogenase
X969_RS00260	COG3436	PFAM IS66 Orf2 family protein
X969_RS00300	COG0358	DNA primase activity
X969_RS00305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
X969_RS00310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X969_RS00315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
X969_RS00320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
X969_RS00330	COG2801	Transposase and inactivated derivatives
X969_RS00340	COG0617	tRNA 3'-terminal CCA addition
X969_RS00345	COG2719	SpoVR family
X969_RS00350	COG2718	Belongs to the UPF0229 family
X969_RS00355	COG2766	serine protein kinase
X969_RS00360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X969_RS00365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
X969_RS00370	COG2967	ApaG domain
X969_RS00375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X969_RS00380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
X969_RS00385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X969_RS00390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
X969_RS00395	COG3178	'Phosphotransferase
X969_RS00400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
X969_RS00405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
X969_RS00415	COG4585	Histidine kinase
X969_RS00420	COG2197	response regulator
X969_RS00425	COG3842	ATPase activity
X969_RS00435	COG1176	ABC-type spermidine putrescine transport system, permease component I
X969_RS00445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X969_RS00450	COG0546	phosphoglycolate phosphatase activity
X969_RS00455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X969_RS00460	COG4625	pathogenesis
X969_RS00460	COG3240	lipase activity
X969_RS00465	COG0512	Glutamine amidotransferase of anthranilate synthase
X969_RS00470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X969_RS00475	COG0134	indole-3-glycerol-phosphate synthase activity
X969_RS00490	COG1765	OsmC-like protein
X969_RS00500	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
X969_RS00505	COG0537	adenosine 5'-monophosphoramidase activity
X969_RS00510	COG0300	oxidoreductase activity
X969_RS00520	COG1981	membrane
X969_RS00525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
X969_RS00530	COG0316	Belongs to the HesB IscA family
X969_RS00535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
X969_RS00540	COG0739	heme binding
X969_RS00545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X969_RS00565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
X969_RS00565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
X969_RS00570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
X969_RS00595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
X969_RS00615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
X969_RS00620	COG0081	regulation of translation
X969_RS00625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
X969_RS00630	COG0222	ribosome binding
X969_RS00635	COG0085	RNA polymerase activity
X969_RS00640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X969_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
X969_RS00650	COG0049	tRNA binding
X969_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X969_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
X969_RS00665	COG0051	transcription antitermination factor activity, RNA binding
X969_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
X969_RS00675	COG0088	Forms part of the polypeptide exit tunnel
X969_RS00680	COG0089	rRNA binding
X969_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X969_RS00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
X969_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
X969_RS00700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
X969_RS00705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
X969_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
X969_RS00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
X969_RS00720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
X969_RS00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
X969_RS00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X969_RS00735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
X969_RS00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
X969_RS00745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
X969_RS00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
X969_RS00755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
X969_RS00760	COG1841	ribosomal large subunit assembly
X969_RS00765	COG0200	Binds to the 23S rRNA
X969_RS00775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
X969_RS00780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X969_RS00785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
X969_RS00790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
X969_RS00795	COG0202	RNA polymerase activity
X969_RS00800	COG0203	ribosomal protein L17
X969_RS00805	COG0753	catalase activity
X969_RS00810	COG2193	ferroxidase activity
X969_RS00815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
X969_RS00820	COG2814	Major facilitator Superfamily
X969_RS00825	COG0629	single-stranded DNA binding
X969_RS00830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS00835	COG0730	response to heat
X969_RS00840	COG4221	oxidoreductase activity
X969_RS00845	COG0243	molybdopterin cofactor binding
X969_RS00845	COG3383	formate dehydrogenase (NAD+) activity
X969_RS00850	COG3383	formate dehydrogenase (NAD+) activity
X969_RS00850	COG0243	molybdopterin cofactor binding
X969_RS00855	COG0437	4 iron, 4 sulfur cluster binding
X969_RS00860	COG2864	formate dehydrogenase
X969_RS00865	COG3058	Necessary for formate dehydrogenase activity
X969_RS00870	COG1921	L-seryl-tRNASec selenium transferase activity
X969_RS00875	COG3276	selenocysteine insertion sequence binding
X969_RS00885	COG0252	asparaginase activity
X969_RS00890	COG1115	amino acid carrier protein
X969_RS00915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X969_RS00930	COG3047	cAMP biosynthetic process
X969_RS00960	COG3118	belongs to the thioredoxin family
X969_RS00965	COG2264	protein methyltransferase activity
X969_RS00975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
X969_RS00980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X969_RS00980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X969_RS00995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
X969_RS01000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X969_RS01005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
X969_RS01010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
X969_RS01020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X969_RS01030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X969_RS01035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
X969_RS01040	COG0142	geranyltranstransferase activity
X969_RS01045	COG1722	exodeoxyribonuclease VII activity
X969_RS01050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X969_RS01055	COG1690	Belongs to the RtcB family
X969_RS01065	COG0579	oxidoreductase
X969_RS01085	COG2132	Multicopper oxidase
X969_RS01095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
X969_RS01105	COG0586	Pfam SNARE associated Golgi protein
X969_RS01110	COG0456	acetyltransferase
X969_RS01115	COG4302	ethanolamine ammonia-lyase activity
X969_RS01120	COG4303	Ethanolamine ammonia lyase large subunit
X969_RS01125	COG0531	amino acid
X969_RS01135	COG3284	Transcriptional regulator
X969_RS01140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X969_RS01155	COG0702	epimerase
X969_RS01165	COG1063	alcohol dehydrogenase
X969_RS01175	COG0022	dehydrogenase e1 component
X969_RS01180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
X969_RS01185	COG3199	ATP-NAD kinase
X969_RS01190	COG3284	Transcriptional regulator
X969_RS01205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
X969_RS01235	COG0023	Translation Initiation Factor
X969_RS01240	COG1166	arginine decarboxylase activity
X969_RS01250	COG3328	transposase activity
X969_RS01255	COG0534	Mate efflux family protein
X969_RS01260	COG2373	Large extracellular alpha-helical protein
X969_RS01270	COG4953	penicillin-binding protein 1C
X969_RS01300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
X969_RS01310	COG2030	dehydratase
X969_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS01325	COG2207	Transcriptional regulator
X969_RS01340	COG2217	Heavy metal translocating P-type atpase
X969_RS01355	COG2814	Major facilitator Superfamily
X969_RS01365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
X969_RS01370	COG0300	oxidoreductase activity
X969_RS01375	COG1739	Uncharacterized protein family UPF0029
X969_RS01380	COG1309	transcriptional regulator
X969_RS01415	COG2995	paraquat-inducible protein a
X969_RS01420	COG2995	paraquat-inducible protein a
X969_RS01425	COG3008	intermembrane lipid transfer
X969_RS01430	COG0268	Binds directly to 16S ribosomal RNA
X969_RS01440	COG0196	riboflavin kinase activity
X969_RS01445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X969_RS01450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
X969_RS01455	COG1047	Peptidyl-prolyl cis-trans
X969_RS01460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
X969_RS01490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS01515	COG0542	response to heat
X969_RS01545	COG1252	NADH dehydrogenase
X969_RS01570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
X969_RS01575	COG0237	dephospho-CoA kinase activity
X969_RS01620	COG3436	PFAM IS66 Orf2 family protein
X969_RS01655	COG4191	Histidine kinase
X969_RS01660	COG0039	L-malate dehydrogenase activity
X969_RS01665	COG0765	amino acid transport
X969_RS01670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS01680	COG0626	cystathionine gamma-synthase activity
X969_RS01685	COG0833	amino acid
X969_RS01690	COG0583	DNA-binding transcription factor activity
X969_RS01700	COG1522	sequence-specific DNA binding
X969_RS01710	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS01725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
X969_RS01740	COG0488	(ABC) transporter
X969_RS01745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X969_RS01750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X969_RS01770	COG1067	ATP-dependent peptidase activity
X969_RS01780	COG2862	Uncharacterized protein family, UPF0114
X969_RS01790	COG0545	Peptidyl-prolyl cis-trans isomerase
X969_RS01800	COG2824	Alkylphosphonate utilization operon protein PhnA
X969_RS01805	COG0142	geranyltranstransferase activity
X969_RS01810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
X969_RS01815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
X969_RS01820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X969_RS01825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
X969_RS01830	COG3045	CreA protein
X969_RS01855	COG0456	acetyltransferase
X969_RS01890	COG2223	nitrite transmembrane transporter activity
X969_RS01905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X969_RS01905	COG2169	Transcriptional regulator
X969_RS01910	COG3264	Mechanosensitive ion channel
X969_RS01910	COG1511	domain protein
X969_RS01945	COG1126	abc transporter atp-binding protein
X969_RS01950	COG0765	amino acid transport
X969_RS01955	COG0765	amino acid transport
X969_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS01965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS01970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X969_RS01975	COG2423	ornithine cyclodeaminase activity
X969_RS01980	COG0006	proline dipeptidase activity
X969_RS01985	COG3608	succinylglutamate desuccinylase aspartoacylase
X969_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS01995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X969_RS02000	COG1335	isochorismatase
X969_RS02015	COG0628	permease
X969_RS02060	COG0582	viral genome integration into host DNA
X969_RS02065	COG0012	GTP binding
X969_RS02070	COG0193	aminoacyl-tRNA hydrolase activity
X969_RS02075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
X969_RS02080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
X969_RS02090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
X969_RS02095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
X969_RS02105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
X969_RS02110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X969_RS02115	COG0574	Belongs to the PEP-utilizing enzyme family
X969_RS02115	COG3848	Pyruvate phosphate dikinase
X969_RS02125	COG1183	phosphatidylcholine synthase activity
X969_RS02135	COG3039	Transposase
X969_RS02140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
X969_RS02145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
X969_RS02155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X969_RS02160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
X969_RS02175	COG0415	Belongs to the DNA photolyase family
X969_RS02180	COG0789	Transcriptional regulator
X969_RS02185	COG3272	Protein of unknown function (DUF1722)
X969_RS02190	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
X969_RS02195	COG1090	epimerase
X969_RS02200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
X969_RS02210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
X969_RS02215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
X969_RS02235	COG0579	oxidoreductase
X969_RS02265	COG2135	peptidase activity
X969_RS02275	COG2119	membrane
X969_RS02280	COG2813	Specifically methylates the guanine in position
X969_RS02285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X969_RS02290	COG0318	PFAM AMP-dependent synthetase and ligase
X969_RS02320	COG2336	PFAM SpoVT AbrB
X969_RS02330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X969_RS02335	COG2885	chlorophyll binding
X969_RS02340	COG0857	belongs to the CobB CobQ family
X969_RS02340	COG0280	phosphate acetyltransferase
X969_RS02355	COG0386	Belongs to the glutathione peroxidase family
X969_RS02380	COG2801	Transposase and inactivated derivatives
X969_RS02385	COG2963	transposase activity
X969_RS02395	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
X969_RS02400	COG0492	ferredoxin-NADP+ reductase activity
X969_RS02405	COG3385	transposase activity
X969_RS02430	COG0084	hydrolase, TatD family'
X969_RS02435	COG1609	Transcriptional regulator
X969_RS02445	COG1105	Belongs to the carbohydrate kinase PfkB family
X969_RS02450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X969_RS02450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
X969_RS02450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
X969_RS02455	COG3530	Putative quorum-sensing-regulated virulence factor
X969_RS02465	COG4251	negative regulation of phosphorylation
X969_RS02465	COG5001	Diguanylate cyclase
X969_RS02465	COG2203	Gaf domain
X969_RS02465	COG3706	GGDEF domain
X969_RS02490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X969_RS02515	COG3604	Transcriptional regulator
X969_RS02520	COG1017	nitric oxide dioxygenase activity
X969_RS02520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X969_RS02525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
X969_RS02530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X969_RS02535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X969_RS02540	COG1845	cytochrome c oxidase, subunit III
X969_RS02545	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
X969_RS02550	COG0109	protoheme IX farnesyltransferase activity
X969_RS02555	COG0436	Aminotransferase
X969_RS02565	COG0727	PFAM Uncharacterised protein family (UPF0153)
X969_RS02580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X969_RS02595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
X969_RS02600	COG0709	Synthesizes selenophosphate from selenide and ATP
X969_RS02605	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
X969_RS02610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X969_RS02615	COG3639	organic phosphonate transmembrane transporter activity
X969_RS02620	COG3639	organic phosphonate transmembrane transporter activity
X969_RS02625	COG3781	membrane
X969_RS02650	COG0765	amino acid transport
X969_RS02655	COG0765	amino acid transport
X969_RS02660	COG0154	amidase activity
X969_RS02690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
X969_RS02695	COG0343	queuine tRNA-ribosyltransferase activity
X969_RS02700	COG1862	Preprotein translocase
X969_RS02715	COG3134	Outer membrane lipoprotein
X969_RS02730	COG1045	serine acetyltransferase
X969_RS02740	COG1104	cysteine desulfurase activity
X969_RS02750	COG0316	Belongs to the HesB IscA family
X969_RS02755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
X969_RS02760	COG0443	Heat shock 70 kDa protein
X969_RS02765	COG0633	Ferredoxin
X969_RS02775	COG0105	UTP biosynthetic process
X969_RS02780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
X969_RS02790	COG1426	Protein conserved in bacteria
X969_RS02795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
X969_RS02800	COG0124	histidyl-tRNA synthetase
X969_RS02815	COG1160	GTP binding
X969_RS02820	COG0436	Aminotransferase
X969_RS02825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X969_RS02835	COG4774	siderophore transport
X969_RS02840	COG3128	pkhd-type hydroxylase
X969_RS02850	COG0019	diaminopimelate decarboxylase activity
X969_RS02865	COG4772	TonB-dependent receptor
X969_RS02890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
X969_RS02905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS02915	COG4608	Belongs to the ABC transporter superfamily
X969_RS02920	COG0444	Belongs to the ABC transporter superfamily
X969_RS02925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X969_RS02930	COG0601	transmembrane transport
X969_RS02935	COG0747	negative chemotaxis
X969_RS02945	COG0747	negative chemotaxis
X969_RS02950	COG0747	negative chemotaxis
X969_RS02965	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
X969_RS02975	COG1113	amino acid transport
X969_RS02980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X969_RS02995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X969_RS03000	COG0154	amidase activity
X969_RS03005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X969_RS03010	COG1077	Cell shape determining protein MreB Mrl
X969_RS03015	COG1792	Involved in formation and maintenance of cell shape
X969_RS03025	COG0424	maF-like protein
X969_RS03040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X969_RS03045	COG0312	modulator of DNA gyrase
X969_RS03050	COG3028	Belongs to the UPF0307 family
X969_RS03055	COG0312	modulator of DNA gyrase
X969_RS03075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X969_RS03080	COG1660	Displays ATPase and GTPase activities
X969_RS03090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X969_RS03095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
X969_RS03100	COG1137	ATPase activity
X969_RS03105	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
X969_RS03115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
X969_RS03125	COG1127	ABC transporter
X969_RS03130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
X969_RS03135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
X969_RS03155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X969_RS03160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
X969_RS03165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
X969_RS03170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X969_RS03175	COG2186	Transcriptional regulator
X969_RS03180	COG2807	transmembrane transport
X969_RS03190	COG2827	Endonuclease containing a URI domain
X969_RS03195	COG3081	Nucleoid-associated protein
X969_RS03200	COG0776	regulation of translation
X969_RS03205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
X969_RS03210	COG0525	valine-tRNA ligase activity
X969_RS03225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
X969_RS03235	COG0795	lipopolysaccharide-transporting ATPase activity
X969_RS03240	COG0795	lipopolysaccharide-transporting ATPase activity
X969_RS03245	COG3385	transposase activity
X969_RS03255	COG1278	Cold shock
X969_RS03260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
X969_RS03265	COG1760	l-serine dehydratase
X969_RS03270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X969_RS03270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X969_RS03275	COG0509	glycine decarboxylation via glycine cleavage system
X969_RS03280	COG1966	Carbon starvation protein
X969_RS03285	COG2879	small protein
X969_RS03300	COG0786	glutamate:sodium symporter activity
X969_RS03320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X969_RS03325	COG2235	arginine
X969_RS03340	COG2832	Protein of unknown function (DUF454)
X969_RS03395	COG1653	transport
X969_RS03400	COG1175	transmembrane transport
X969_RS03410	COG3842	ATPase activity
X969_RS03420	COG0676	glucose-6-phosphate 1-epimerase activity
X969_RS03425	COG1737	Transcriptional regulator
X969_RS03440	COG0800	Aldolase
X969_RS03445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X969_RS03450	COG0739	heme binding
X969_RS03455	COG1570	exodeoxyribonuclease VII activity
X969_RS03460	COG0583	DNA-binding transcription factor activity
X969_RS03480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X969_RS03480	COG0519	Catalyzes the synthesis of GMP from XMP
X969_RS03490	COG1397	ADP-ribosylglycohydrolase
X969_RS03495	COG2369	cell adhesion
X969_RS03505	COG0590	tRNA wobble adenosine to inosine editing
X969_RS03510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
X969_RS03515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X969_RS03515	COG0047	phosphoribosylformylglycinamidine synthase activity
X969_RS03530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X969_RS03535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X969_RS03565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X969_RS03630	COG0494	nUDIX hydrolase
X969_RS03650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
X969_RS03655	COG0477	Major facilitator Superfamily
X969_RS03660	COG4536	flavin adenine dinucleotide binding
X969_RS03670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X969_RS03675	COG0228	four-way junction DNA binding
X969_RS03680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
X969_RS03685	COG0336	Belongs to the RNA methyltransferase TrmD family
X969_RS03690	COG0335	large ribosomal subunit rRNA binding
X969_RS03695	COG1607	acyl-coa hydrolase
X969_RS03700	COG4974	Belongs to the 'phage' integrase family
X969_RS03735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X969_RS03760	COG2801	Transposase and inactivated derivatives
X969_RS03770	COG1902	pentaerythritol trinitrate reductase activity
X969_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS03785	COG1177	transmembrane transport
X969_RS03790	COG1176	ABC-type spermidine putrescine transport system, permease component I
X969_RS03795	COG3842	ATPase activity
X969_RS03800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
X969_RS03805	COG2979	Protein of unknown function (DUF533)
X969_RS03810	COG0840	transmembrane signaling receptor activity
X969_RS03820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X969_RS03820	COG0457	Tetratricopeptide repeat
X969_RS03835	COG2201	protein-glutamate methylesterase activity
X969_RS03840	COG5001	Diguanylate cyclase
X969_RS03840	COG2203	Gaf domain
X969_RS03840	COG3706	GGDEF domain
X969_RS03840	COG4251	negative regulation of phosphorylation
X969_RS03850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
X969_RS03870	COG1073	alpha beta
X969_RS03880	COG2885	chlorophyll binding
X969_RS03895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
X969_RS03900	COG0563	adenylate kinase activity
X969_RS03935	COG0742	ribosomal rna small subunit methyltransferase
X969_RS03945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS03975	COG2937	Belongs to the GPAT DAPAT family
X969_RS03990	COG2226	methyltransferase
X969_RS03995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X969_RS04000	COG1215	transferase activity, transferring glycosyl groups
X969_RS04005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
X969_RS04015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X969_RS04020	COG2171	N-acyltransferase activity
X969_RS04025	COG1393	Belongs to the ArsC family
X969_RS04030	COG0025	NhaP-type Na H and K H
X969_RS04035	COG0436	Aminotransferase
X969_RS04040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
X969_RS04045	COG0024	Methionine aminopeptidase
X969_RS04050	COG0052	Belongs to the universal ribosomal protein uS2 family
X969_RS04055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
X969_RS04060	COG0528	UMP kinase activity
X969_RS04065	COG0233	cytoplasmic translational termination
X969_RS04070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X969_RS04080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
X969_RS04100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
X969_RS04105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
X969_RS04110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
X969_RS04115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
X969_RS04120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X969_RS04130	COG0825	malonyl-CoA metabolic process
X969_RS04135	COG0037	tRNA processing
X969_RS04140	COG0504	CTP synthase activity
X969_RS04145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
X969_RS04150	COG0148	phosphopyruvate hydratase activity
X969_RS04160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
X969_RS04170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
X969_RS04180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
X969_RS04185	COG0585	pseudouridine synthase activity
X969_RS04190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
X969_RS04195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
X969_RS04210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
X969_RS04215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
X969_RS04220	COG1546	Belongs to the CinA family
X969_RS04225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X969_RS04230	COG2137	regulation of response to DNA damage stimulus
X969_RS04250	COG3148	PFAM DTW domain containing protein
X969_RS04265	COG0583	DNA-binding transcription factor activity
X969_RS04275	COG3091	SprT-like family
X969_RS04285	COG0037	tRNA processing
X969_RS04305	COG1393	Belongs to the ArsC family
X969_RS04325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X969_RS04330	COG2205	protein histidine kinase activity
X969_RS04330	COG5002	protein histidine kinase activity
X969_RS04330	COG0784	Response regulator, receiver
X969_RS04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X969_RS04355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X969_RS04360	COG3956	TIGRFAM MazG family protein
X969_RS04365	COG3122	Protein conserved in bacteria
X969_RS04380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X969_RS04385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
X969_RS04395	COG0628	permease
X969_RS04405	COG0791	NLP P60 protein
X969_RS04410	COG0791	NLP P60 protein
X969_RS04440	COG1797	cobyrinic acid a,c-diamide synthase activity
X969_RS04445	COG0778	Nitroreductase
X969_RS04460	COG1492	cobalamin metabolic process
X969_RS04470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
X969_RS04475	COG0406	alpha-ribazole phosphatase activity
X969_RS04480	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
X969_RS04490	COG1846	Transcriptional regulator
X969_RS04525	COG2433	Pfam Transposase IS66
X969_RS04535	COG0583	DNA-binding transcription factor activity
X969_RS04565	COG2205	protein histidine kinase activity
X969_RS04570	COG2814	Major facilitator Superfamily
X969_RS04575	COG0477	Major facilitator Superfamily
X969_RS04580	COG2076	Multidrug Resistance protein
X969_RS04585	COG0385	Bile acid
X969_RS04590	COG2974	May be involved in recombination
X969_RS04615	COG0024	Methionine aminopeptidase
X969_RS04620	COG0243	molybdopterin cofactor binding
X969_RS04625	COG2146	nitrite reductase [NAD(P)H] activity
X969_RS04625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X969_RS04630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X969_RS04630	COG2146	nitrite reductase [NAD(P)H] activity
X969_RS04635	COG0583	DNA-binding transcription factor activity
X969_RS04640	COG0545	Peptidyl-prolyl cis-trans isomerase
X969_RS04645	COG3339	Conserved Protein
X969_RS04660	COG5001	Diguanylate cyclase
X969_RS04660	COG3300	MHYT domain
X969_RS04690	COG0395	ABC-type sugar transport system, permease component
X969_RS04710	COG0668	transmembrane transport
X969_RS04715	COG1362	aminopeptidase activity
X969_RS04720	COG0564	pseudouridine synthase activity
X969_RS04725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
X969_RS04730	COG2894	cell division
X969_RS04735	COG0850	regulation of cytokinetic process
X969_RS04740	COG1560	Kdo2-lipid A biosynthetic process
X969_RS04750	COG2853	Lipoprotein
X969_RS04770	COG2113	Glycine betaine
X969_RS04775	COG3162	membrane
X969_RS04780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X969_RS04795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X969_RS04800	COG3089	Belongs to the UPF0270 family
X969_RS04805	COG1363	Peptidase, m42
X969_RS04810	COG0189	ligase activity
X969_RS04810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X969_RS04815	COG0367	asparagine synthase
X969_RS04820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS04820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
X969_RS04825	COG2326	polyphosphate kinase activity
X969_RS04830	COG0697	spore germination
X969_RS04835	COG0114	fumarate hydratase activity
X969_RS04845	COG0271	Belongs to the BolA IbaG family
X969_RS04850	COG1054	Belongs to the UPF0176 family
X969_RS04865	COG5002	protein histidine kinase activity
X969_RS04865	COG5001	Diguanylate cyclase
X969_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS04880	COG0546	phosphoglycolate phosphatase activity
X969_RS04885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
X969_RS04890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
X969_RS04900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
X969_RS04910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X969_RS04915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
X969_RS04925	COG0776	regulation of translation
X969_RS04935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
X969_RS04945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X969_RS05010	COG1216	Glycosyl transferase, family 2
X969_RS05020	COG0438	transferase activity, transferring glycosyl groups
X969_RS05020	COG1216	Glycosyl transferase, family 2
X969_RS05045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS05055	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
X969_RS05065	COG0438	transferase activity, transferring glycosyl groups
X969_RS05080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X969_RS05095	COG0166	Belongs to the GPI family
X969_RS05105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
X969_RS05110	COG1555	photosystem II stabilization
X969_RS05115	COG0284	orotidine-5'-phosphate decarboxylase activity
X969_RS05125	COG1215	transferase activity, transferring glycosyl groups
X969_RS05140	COG2130	NADP-dependent
X969_RS05155	COG0436	Aminotransferase
X969_RS05160	COG0840	transmembrane signaling receptor activity
X969_RS05165	COG3135	benzoate transporter
X969_RS05170	COG0625	glutathione transferase activity
X969_RS05180	COG0302	gtp cyclohydrolase
X969_RS05185	COG2840	Smr protein MutS2
X969_RS05215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
X969_RS05220	COG2814	Major facilitator Superfamily
X969_RS05225	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
X969_RS05255	COG1368	sulfuric ester hydrolase activity
X969_RS05275	COG0519	Catalyzes the synthesis of GMP from XMP
X969_RS05280	COG0598	Magnesium transport protein CorA
X969_RS05285	COG0204	Acyl-transferase
X969_RS05310	COG2814	Major facilitator Superfamily
X969_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS05320	COG0583	DNA-binding transcription factor activity
X969_RS05340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
X969_RS05345	COG1764	response to oxidative stress
X969_RS05350	COG1846	Transcriptional regulator
X969_RS05355	COG0583	DNA-binding transcription factor activity
X969_RS05365	COG0583	DNA-binding transcription factor activity
X969_RS05375	COG3214	Protein conserved in bacteria
X969_RS05380	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
X969_RS05395	COG3384	dioxygenase
X969_RS05400	COG0500	methyltransferase
X969_RS05405	COG0501	Belongs to the peptidase M48B family
X969_RS05410	COG0436	Aminotransferase
X969_RS05415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X969_RS05420	COG0386	Belongs to the glutathione peroxidase family
X969_RS05425	COG2205	protein histidine kinase activity
X969_RS05425	COG3437	response regulator, receiver
X969_RS05425	COG4999	Histidine kinase
X969_RS05425	COG3850	Histidine kinase
X969_RS05435	COG1956	GAF domain-containing protein
X969_RS05475	COG3188	usher protein
X969_RS05480	COG3039	Transposase
X969_RS05485	COG3121	Chaperone
X969_RS05500	COG1960	acyl-CoA dehydrogenase activity
X969_RS05505	COG0625	glutathione transferase activity
X969_RS05510	COG1131	(ABC) transporter
X969_RS05515	COG0842	Transport permease protein
X969_RS05525	COG2333	competence protein COMEC
X969_RS05525	COG0658	competence protein
X969_RS05530	COG0811	peptide transport
X969_RS05535	COG0848	biopolymer transport protein
X969_RS05540	COG1663	tetraacyldisaccharide 4'-kinase activity
X969_RS05545	COG2835	tetraacyldisaccharide 4'-kinase activity
X969_RS05550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
X969_RS05555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X969_RS05560	COG0812	UDP-N-acetylmuramate dehydrogenase activity
X969_RS05565	COG1530	ribonuclease E activity
X969_RS05575	COG0546	phosphoglycolate phosphatase activity
X969_RS05580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
X969_RS05580	COG0616	signal peptide processing
X969_RS05585	COG0424	maF-like protein
X969_RS05595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
X969_RS05600	COG0416	fatty acid biosynthetic process
X969_RS05605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
X969_RS05615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X969_RS05620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X969_RS05630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X969_RS05635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X969_RS05645	COG0084	hydrolase, TatD family'
X969_RS05655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X969_RS05690	COG0556	nucleotide-excision repair
X969_RS05705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X969_RS05760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X969_RS05770	COG3385	transposase activity
X969_RS05785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
X969_RS05790	COG0066	3-isopropylmalate dehydratase activity
X969_RS05795	COG2226	methyltransferase
X969_RS05800	COG0473	3-isopropylmalate dehydrogenase activity
X969_RS05825	COG0135	phosphoribosylanthranilate isomerase activity
X969_RS05830	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
X969_RS05835	COG0285	dihydrofolate synthase activity
X969_RS05845	COG1286	toxin biosynthetic process
X969_RS05890	COG0697	spore germination
X969_RS05895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS05910	COG0446	pyridine nucleotide-disulphide oxidoreductase
X969_RS05910	COG1902	pentaerythritol trinitrate reductase activity
X969_RS05920	COG3038	cytochrome b561
X969_RS05930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X969_RS05935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
X969_RS05940	COG0705	Rhomboid family
X969_RS05945	COG3139	Protein of unknown function (DUF1315)
X969_RS05955	COG0308	aminopeptidase N
X969_RS05975	COG2706	6-phosphogluconolactonase activity
X969_RS05995	COG0420	3'-5' exonuclease activity
X969_RS06000	COG3209	COG3209 Rhs family protein
X969_RS06065	COG0714	Associated with various cellular activities
X969_RS06080	COG3135	benzoate transporter
X969_RS06090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X969_RS06125	COG2814	Major facilitator Superfamily
X969_RS06135	COG0789	Transcriptional regulator
X969_RS06140	COG2188	Transcriptional regulator
X969_RS06155	COG0019	diaminopimelate decarboxylase activity
X969_RS06160	COG0583	DNA-binding transcription factor activity
X969_RS06175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
X969_RS06190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
X969_RS06205	COG0668	transmembrane transport
X969_RS06230	COG2223	nitrite transmembrane transporter activity
X969_RS06235	COG3707	response regulator
X969_RS06240	COG1116	anion transmembrane transporter activity
X969_RS06240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X969_RS06245	COG0167	dihydroorotate dehydrogenase activity
X969_RS06250	COG0116	Belongs to the methyltransferase superfamily
X969_RS06250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X969_RS06265	COG2027	D-alanyl-D-alanine carboxypeptidase
X969_RS06270	COG3171	Protein conserved in bacteria
X969_RS06275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS06275	COG2205	protein histidine kinase activity
X969_RS06280	COG2197	response regulator
X969_RS06305	COG0004	ammonium transporteR
X969_RS06325	COG0564	pseudouridine synthase activity
X969_RS06330	COG0840	transmembrane signaling receptor activity
X969_RS06345	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
X969_RS06355	COG0425	Belongs to the sulfur carrier protein TusA family
X969_RS06360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X969_RS06365	COG1132	(ABC) transporter
X969_RS06390	COG0521	Mo-molybdopterin cofactor biosynthetic process
X969_RS06405	COG1597	lipid kinase activity
X969_RS06410	COG2197	response regulator
X969_RS06415	COG3851	Histidine kinase
X969_RS06430	COG0835	chemotaxis
X969_RS06430	COG0784	Response regulator, receiver
X969_RS06440	COG0741	lytic transglycosylase activity
X969_RS06445	COG0488	(ABC) transporter
X969_RS06450	COG0589	response to stress
X969_RS06465	COG0183	Belongs to the thiolase family
X969_RS06495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X969_RS06505	COG1376	ErfK ybiS ycfS ynhG family protein
X969_RS06520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X969_RS06530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
X969_RS06540	COG1477	protein flavinylation
X969_RS06545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X969_RS06550	COG0584	glycerophosphoryl diester phosphodiesterase
X969_RS06560	COG4591	ABC-type transport system involved in lipoprotein release permease component
X969_RS06565	COG1136	(ABC) transporter
X969_RS06570	COG4591	ABC-type transport system involved in lipoprotein release permease component
X969_RS06585	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
X969_RS06585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
X969_RS06600	COG2853	Lipoprotein
X969_RS06610	COG4566	intracellular signal transduction
X969_RS06625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
X969_RS06630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X969_RS06665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X969_RS06670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
X969_RS06675	COG2814	Major facilitator Superfamily
X969_RS06695	COG1414	Transcriptional regulator
X969_RS06710	COG3383	formate dehydrogenase (NAD+) activity
X969_RS06720	COG0589	response to stress
X969_RS06745	COG1595	DNA-templated transcription, initiation
X969_RS06765	COG0010	Belongs to the arginase family
X969_RS06775	COG2133	pyrroloquinoline quinone binding
X969_RS06780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
X969_RS06790	COG0596	Alpha beta hydrolase
X969_RS06795	COG1238	metal cluster binding
X969_RS06810	COG0826	peptidase U32
X969_RS06825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X969_RS06830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
X969_RS06835	COG0583	DNA-binding transcription factor activity
X969_RS06855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X969_RS06865	COG0183	Belongs to the thiolase family
X969_RS06870	COG1960	acyl-CoA dehydrogenase activity
X969_RS06875	COG1024	Enoyl-CoA hydratase
X969_RS06915	COG1320	monovalent cation:proton antiporter activity
X969_RS06920	COG2212	antiporter activity
X969_RS06930	COG0651	ATP synthesis coupled electron transport
X969_RS06935	COG1006	Multisubunit Na H antiporter MnhC subunit
X969_RS06940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X969_RS06940	COG2111	Na H antiporter
X969_RS06955	COG1335	isochorismatase
X969_RS07010	COG4178	(ABC) transporter
X969_RS07030	COG0730	response to heat
X969_RS07045	COG0251	oxidation-reduction process
X969_RS07050	COG3949	Membrane
X969_RS07055	COG0840	transmembrane signaling receptor activity
X969_RS07060	COG0583	DNA-binding transcription factor activity
X969_RS07080	COG2186	Transcriptional regulator
X969_RS07095	COG0840	transmembrane signaling receptor activity
X969_RS07110	COG2423	ornithine cyclodeaminase activity
X969_RS07115	COG3284	Transcriptional regulator
X969_RS07120	COG3842	ATPase activity
X969_RS07125	COG3842	ATPase activity
X969_RS07135	COG0395	ABC-type sugar transport system, permease component
X969_RS07150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
X969_RS07180	COG0544	peptidyl-prolyl cis-trans isomerase activity
X969_RS07185	COG0740	serine-type endopeptidase activity
X969_RS07190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
X969_RS07195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
X969_RS07205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X969_RS07245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
X969_RS07250	COG2259	Doxx family
X969_RS07260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X969_RS07290	COG3436	PFAM IS66 Orf2 family protein
X969_RS07310	COG0579	oxidoreductase
X969_RS07315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X969_RS07345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X969_RS07350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
X969_RS07355	COG4181	ATPase activity
X969_RS07370	COG1376	ErfK ybiS ycfS ynhG family protein
X969_RS07370	COG1388	LysM domain
X969_RS07385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
X969_RS07390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X969_RS07395	COG0589	response to stress
X969_RS07425	COG4067	protein conserved in archaea
X969_RS07425	COG0189	ligase activity
X969_RS07430	COG1802	Transcriptional regulator
X969_RS07440	COG0372	Belongs to the citrate synthase family
X969_RS07455	COG2079	MmgE PrpD family protein
X969_RS07470	COG0720	synthase
X969_RS07500	COG0517	IMP dehydrogenase activity
X969_RS07515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
X969_RS07545	COG4251	negative regulation of phosphorylation
X969_RS07585	COG2866	Carboxypeptidase
X969_RS07590	COG2207	Transcriptional regulator
X969_RS07595	COG2223	nitrite transmembrane transporter activity
X969_RS07605	COG2853	Lipoprotein
X969_RS07615	COG2205	protein histidine kinase activity
X969_RS07640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X969_RS07665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
X969_RS07670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
X969_RS07670	COG0316	Belongs to the HesB IscA family
X969_RS07675	COG1999	signal sequence binding
X969_RS07690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
X969_RS07705	COG1982	Orn Lys Arg decarboxylase major
X969_RS07710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X969_RS07750	COG0583	DNA-binding transcription factor activity
X969_RS07755	COG0417	DNA replication proofreading
X969_RS07775	COG3220	belongs to the UPF0276 family
X969_RS07785	COG2259	Doxx family
X969_RS07815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X969_RS07820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
X969_RS07845	COG4774	siderophore transport
X969_RS07855	COG1192	Involved in chromosome partitioning
X969_RS07875	COG1120	ATPase activity
X969_RS07880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X969_RS07895	COG4774	siderophore transport
X969_RS07900	COG0583	DNA-binding transcription factor activity
X969_RS07910	COG1253	flavin adenine dinucleotide binding
X969_RS07920	COG2801	Transposase and inactivated derivatives
X969_RS07930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS07970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X969_RS08020	COG1484	DNA-dependent DNA replication
X969_RS08025	COG0305	Participates in initiation and elongation during chromosome replication
X969_RS08070	COG4626	Terminase
X969_RS08070	COG1802	Transcriptional regulator
X969_RS08190	COG2135	peptidase activity
X969_RS08240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X969_RS08250	COG0252	asparaginase activity
X969_RS08255	COG1879	ABC-type sugar transport system periplasmic component
X969_RS08260	COG1129	ABC transporter
X969_RS08265	COG1172	Belongs to the binding-protein-dependent transport system permease family
X969_RS08270	COG1609	Transcriptional regulator
X969_RS08275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X969_RS08280	COG1869	D-ribose catabolic process
X969_RS08300	COG3385	transposase activity
X969_RS08305	COG1278	Cold shock
X969_RS08315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X969_RS08320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X969_RS08325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
X969_RS08330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
X969_RS08335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
X969_RS08340	COG0072	phenylalanine-tRNA ligase activity
X969_RS08345	COG0776	regulation of translation
X969_RS08360	COG2204	response regulator
X969_RS08385	COG2066	Belongs to the glutaminase family
X969_RS08390	COG2186	Transcriptional regulator
X969_RS08415	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS08435	COG3039	Transposase
X969_RS08460	COG2873	o-acetylhomoserine
X969_RS08475	COG4977	sequence-specific DNA binding
X969_RS08495	COG0583	DNA-binding transcription factor activity
X969_RS08500	COG2814	Major facilitator Superfamily
X969_RS08505	COG0625	glutathione transferase activity
X969_RS08525	COG2271	Major facilitator Superfamily
X969_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS08550	COG1063	alcohol dehydrogenase
X969_RS08555	COG2814	Major facilitator Superfamily
X969_RS08560	COG1902	pentaerythritol trinitrate reductase activity
X969_RS08570	COG0583	DNA-binding transcription factor activity
X969_RS08595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS08605	COG4106	trans-aconitate 2-methyltransferase activity
X969_RS08615	COG0583	DNA-binding transcription factor activity
X969_RS08625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS08630	COG0217	transcriptional regulatory protein
X969_RS08635	COG0583	DNA-binding transcription factor activity
X969_RS08640	COG0076	glutamate decarboxylase activity
X969_RS08645	COG0477	Major facilitator Superfamily
X969_RS08650	COG3185	4-Hydroxyphenylpyruvate dioxygenase
X969_RS08650	COG1082	Xylose isomerase domain protein TIM barrel
X969_RS08665	COG5001	Diguanylate cyclase
X969_RS08665	COG3300	MHYT domain
X969_RS08695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
X969_RS08705	COG1301	dicarboxylic acid transport
X969_RS08710	COG0583	DNA-binding transcription factor activity
X969_RS08725	COG0210	DNA helicase
X969_RS08735	COG0596	Alpha beta hydrolase
X969_RS08745	COG0596	Alpha beta hydrolase
X969_RS08750	COG0477	Major facilitator Superfamily
X969_RS08775	COG0300	oxidoreductase activity
X969_RS08795	COG0346	lactoylglutathione lyase activity
X969_RS08820	COG2995	paraquat-inducible protein a
X969_RS08825	COG3008	intermembrane lipid transfer
X969_RS08835	COG2194	sulfuric ester hydrolase activity
X969_RS08855	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS08860	COG0531	amino acid
X969_RS08865	COG2197	response regulator
X969_RS08875	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS08880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
X969_RS08885	COG1053	succinate dehydrogenase
X969_RS08895	COG0673	inositol 2-dehydrogenase activity
X969_RS08910	COG1053	succinate dehydrogenase
X969_RS08920	COG1053	succinate dehydrogenase
X969_RS08925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X969_RS08930	COG1414	Transcriptional regulator
X969_RS08955	COG1177	transmembrane transport
X969_RS08960	COG1176	ABC-type spermidine putrescine transport system, permease component I
X969_RS08965	COG3842	ATPase activity
X969_RS08970	COG1414	Transcriptional regulator
X969_RS08975	COG1132	(ABC) transporter
X969_RS08985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
X969_RS08995	COG1984	allophanate hydrolase subunit 2
X969_RS09030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X969_RS09035	COG3217	Mosc domain protein beta barrel domain protein
X969_RS09035	COG0633	Ferredoxin
X969_RS09065	COG3158	transport of potassium into the cell
X969_RS09075	COG3328	transposase activity
X969_RS09095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
X969_RS09105	COG0581	inorganic phosphate transmembrane transporter activity
X969_RS09110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X969_RS09130	COG0174	glutamine synthetase
X969_RS09135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X969_RS09160	COG3046	protein related to deoxyribodipyrimidine photolyase
X969_RS09170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
X969_RS09185	COG4221	oxidoreductase activity
X969_RS09195	COG2202	Pas domain
X969_RS09195	COG1366	Belongs to the anti-sigma-factor antagonist family
X969_RS09200	COG0789	Transcriptional regulator
X969_RS09215	COG0784	Response regulator, receiver
X969_RS09215	COG2205	protein histidine kinase activity
X969_RS09235	COG1131	(ABC) transporter
X969_RS09250	COG4585	Histidine kinase
X969_RS09310	COG4191	Histidine kinase
X969_RS09315	COG0659	secondary active sulfate transmembrane transporter activity
X969_RS09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS09330	COG1538	Outer membrane efflux protein
X969_RS09335	COG0477	Major facilitator Superfamily
X969_RS09340	COG3958	Transketolase
X969_RS09345	COG3959	Transketolase, thiamine diphosphate binding domain
X969_RS09350	COG0371	Dehydrogenase
X969_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS09360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X969_RS09370	COG1454	alcohol dehydrogenase
X969_RS09380	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS09390	COG1129	ABC transporter
X969_RS09395	COG1172	Belongs to the binding-protein-dependent transport system permease family
X969_RS09400	COG1802	Transcriptional regulator
X969_RS09405	COG2116	formate transmembrane transporter activity
X969_RS09435	COG0668	transmembrane transport
X969_RS09450	COG2323	membrane
X969_RS09460	COG1058	Belongs to the CinA family
X969_RS09460	COG1546	Belongs to the CinA family
X969_RS09470	COG1063	alcohol dehydrogenase
X969_RS09530	COG0583	DNA-binding transcription factor activity
X969_RS09535	COG0583	DNA-binding transcription factor activity
X969_RS09540	COG3321	synthase
X969_RS09540	COG4221	oxidoreductase activity
X969_RS09540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
X969_RS09540	COG0604	alcohol dehydrogenase
X969_RS09550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X969_RS09555	COG0431	NADPH-dependent FMN reductase
X969_RS09560	COG0798	PFAM Bile acid sodium symporter
X969_RS09565	COG0640	Transcriptional regulator
X969_RS09585	COG0583	DNA-binding transcription factor activity
X969_RS09590	COG2828	Protein conserved in bacteria
X969_RS09595	COG1301	dicarboxylic acid transport
X969_RS09600	COG2851	Citrate transporter
X969_RS09615	COG4251	negative regulation of phosphorylation
X969_RS09615	COG3706	GGDEF domain
X969_RS09615	COG2203	Gaf domain
X969_RS09615	COG5001	Diguanylate cyclase
X969_RS09620	COG1090	epimerase
X969_RS09715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X969_RS09720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X969_RS09730	COG1305	Transglutaminase-like
X969_RS09740	COG2308	Evidence 4 Homologs of previously reported genes of
X969_RS09745	COG2271	Major facilitator Superfamily
X969_RS09750	COG1082	Xylose isomerase domain protein TIM barrel
X969_RS09765	COG5001	Diguanylate cyclase
X969_RS09765	COG3300	MHYT domain
X969_RS09780	COG4176	ABC-type proline glycine betaine transport system permease component
X969_RS09785	COG0517	IMP dehydrogenase activity
X969_RS09785	COG4175	Glycine betaine
X969_RS09790	COG2986	histidine ammonia-lyase
X969_RS09800	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS09805	COG0668	transmembrane transport
X969_RS09815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X969_RS09840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
X969_RS09870	COG0071	Belongs to the small heat shock protein (HSP20) family
X969_RS09880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X969_RS09895	COG2217	Heavy metal translocating P-type atpase
X969_RS09900	COG0459	protein refolding
X969_RS09905	COG0589	response to stress
X969_RS09915	COG0589	response to stress
X969_RS09925	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X969_RS09930	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS09935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X969_RS09940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X969_RS09950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X969_RS09995	COG2249	NAD(P)H dehydrogenase (quinone) activity
X969_RS10020	COG0583	DNA-binding transcription factor activity
X969_RS10025	COG1794	racemase activity, acting on amino acids and derivatives
X969_RS10030	COG2963	transposase activity
X969_RS10035	COG2801	Transposase and inactivated derivatives
X969_RS10040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X969_RS10040	COG0519	Catalyzes the synthesis of GMP from XMP
X969_RS10050	COG1285	pathogenesis
X969_RS10065	COG2264	protein methyltransferase activity
X969_RS10070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
X969_RS10075	COG0693	protein deglycase activity
X969_RS10085	COG0708	Exodeoxyribonuclease III
X969_RS10105	COG3387	PFAM Glycoside hydrolase 15-related
X969_RS10110	COG2323	membrane
X969_RS10120	COG1546	Belongs to the CinA family
X969_RS10120	COG1058	Belongs to the CinA family
X969_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS10175	COG3920	Histidine kinase
X969_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS10200	COG1063	alcohol dehydrogenase
X969_RS10210	COG1271	oxidase subunit
X969_RS10220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
X969_RS10225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
X969_RS10230	COG2080	2 iron, 2 sulfur cluster binding
X969_RS10235	COG0028	Belongs to the TPP enzyme family
X969_RS10260	COG3039	Transposase
X969_RS10345	COG2135	peptidase activity
X969_RS10415	COG2963	transposase activity
X969_RS10420	COG2801	Transposase and inactivated derivatives
X969_RS10495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X969_RS10540	COG1192	Involved in chromosome partitioning
X969_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS10645	COG3971	2-oxopent-4-enoate hydratase activity
X969_RS10650	COG4569	acetaldehyde dehydrogenase (acetylating) activity
X969_RS10655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X969_RS10660	COG1024	Enoyl-CoA hydratase
X969_RS10680	COG2267	carboxylic ester hydrolase activity
X969_RS10685	COG4638	Rieske (2fe-2S)
X969_RS10690	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
X969_RS10695	COG2146	nitrite reductase [NAD(P)H] activity
X969_RS10700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X969_RS10710	COG0346	lactoylglutathione lyase activity
X969_RS10715	COG3971	2-oxopent-4-enoate hydratase activity
X969_RS10720	COG4569	acetaldehyde dehydrogenase (acetylating) activity
X969_RS10725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X969_RS10730	COG0745	RESPONSE REGULATOR receiver
X969_RS10730	COG4191	Histidine kinase
X969_RS10730	COG2205	protein histidine kinase activity
X969_RS10735	COG4566	intracellular signal transduction
X969_RS10740	COG1538	Outer membrane efflux protein
X969_RS10750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS10770	COG0604	alcohol dehydrogenase
X969_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS10770	COG3321	synthase
X969_RS10780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS10790	COG4948	Mandelate Racemase Muconate Lactonizing
X969_RS10800	COG0582	viral genome integration into host DNA
X969_RS10955	COG3617	BRO family, N-terminal domain
X969_RS11130	COG1196	nuclear chromosome segregation
X969_RS11175	COG3617	BRO family, N-terminal domain
X969_RS11225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
X969_RS11255	COG0583	DNA-binding transcription factor activity
X969_RS11260	COG2721	sulfolactate sulfo-lyase activity
X969_RS11275	COG2271	Major facilitator Superfamily
X969_RS11285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X969_RS11285	COG1199	ATP-dependent helicase activity
X969_RS11295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
X969_RS11300	COG0829	nickel cation binding
X969_RS11305	COG0831	urea catabolic process
X969_RS11310	COG0832	Belongs to the urease beta subunit family
X969_RS11315	COG0804	urea catabolic process
X969_RS11320	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
X969_RS11330	COG0830	nickel cation binding
X969_RS11335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
X969_RS11390	COG0840	transmembrane signaling receptor activity
X969_RS11395	COG1968	undecaprenyl-diphosphatase activity
X969_RS11415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
X969_RS11420	COG1252	NADH dehydrogenase
X969_RS11430	COG0446	pyridine nucleotide-disulphide oxidoreductase
X969_RS11430	COG1902	pentaerythritol trinitrate reductase activity
X969_RS11440	COG0235	Class ii aldolase
X969_RS11450	COG0393	Putative heavy-metal-binding
X969_RS11490	COG4221	oxidoreductase activity
X969_RS11500	COG1917	Cupin 2, conserved barrel domain protein
X969_RS11500	COG1396	sequence-specific DNA binding
X969_RS11510	COG3038	cytochrome b561
X969_RS11520	COG1595	DNA-templated transcription, initiation
X969_RS11575	COG3064	Membrane
X969_RS11595	COG0583	DNA-binding transcription factor activity
X969_RS11605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
X969_RS11610	COG0488	(ABC) transporter
X969_RS11645	COG2204	response regulator
X969_RS11650	COG0625	glutathione transferase activity
X969_RS11665	COG0488	(ABC) transporter
X969_RS11670	COG2135	peptidase activity
X969_RS11680	COG1858	cytochrome C peroxidase
X969_RS11710	COG1301	dicarboxylic acid transport
X969_RS11745	COG2175	clavaminate synthase activity
X969_RS11750	COG3246	L-lysine catabolic process to acetate
X969_RS11755	COG2814	Major facilitator Superfamily
X969_RS11770	COG2855	membrane
X969_RS11805	COG1960	acyl-CoA dehydrogenase activity
X969_RS11810	COG0318	PFAM AMP-dependent synthetase and ligase
X969_RS11820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X969_RS11840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
X969_RS11870	COG2801	Transposase and inactivated derivatives
X969_RS11875	COG2963	transposase activity
X969_RS12070	COG3179	chitinase
X969_RS12080	COG3436	PFAM IS66 Orf2 family protein
X969_RS12125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X969_RS12130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X969_RS12135	COG4574	serine-type endopeptidase inhibitor activity
X969_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS12145	COG2610	gluconate transmembrane transporter activity
X969_RS12150	COG3829	transcription factor binding
X969_RS12150	COG3290	protein histidine kinase activity
X969_RS12155	COG4239	(ABC) transporter, permease
X969_RS12160	COG4174	ABC transporter (Permease)
X969_RS12165	COG4166	transmembrane transport
X969_RS12170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X969_RS12175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
X969_RS12180	COG1881	PFAM PEBP family protein
X969_RS12190	COG2356	endonuclease I
X969_RS12200	COG2814	Major facilitator Superfamily
X969_RS12215	COG0531	amino acid
X969_RS12225	COG2197	response regulator
X969_RS12230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X969_RS12250	COG0678	peroxiredoxin activity
X969_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS12260	COG0583	DNA-binding transcription factor activity
X969_RS12275	COG0028	Belongs to the TPP enzyme family
X969_RS12325	COG0583	DNA-binding transcription factor activity
X969_RS12335	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
X969_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS12345	COG4977	sequence-specific DNA binding
X969_RS12375	COG1522	sequence-specific DNA binding
X969_RS12425	COG3327	negative regulation of DNA-templated transcription, initiation
X969_RS12435	COG1024	Enoyl-CoA hydratase
X969_RS12440	COG1024	Enoyl-CoA hydratase
X969_RS12445	COG1250	3-hydroxyacyl-CoA dehydrogenase
X969_RS12450	COG2050	protein possibly involved in aromatic compounds catabolism
X969_RS12455	COG0183	Belongs to the thiolase family
X969_RS12465	COG3396	Phenylacetate-CoA oxygenase
X969_RS12470	COG3460	Phenylacetate-CoA oxygenase
X969_RS12475	COG3396	Phenylacetate-CoA oxygenase
X969_RS12480	COG2151	metal-sulfur cluster biosynthetic enzyme
X969_RS12485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X969_RS12490	COG3162	membrane
X969_RS12505	COG2030	dehydratase
X969_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS12525	COG0494	nUDIX hydrolase
X969_RS12545	COG3568	Endonuclease Exonuclease Phosphatase
X969_RS12550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X969_RS12555	COG0392	lysyltransferase activity
X969_RS12585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X969_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS12615	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
X969_RS12620	COG2890	protein-(glutamine-N5) methyltransferase activity
X969_RS12645	COG0667	Aldo Keto reductase
X969_RS12650	COG2837	iron assimilation
X969_RS12655	COG0385	Bile acid
X969_RS12680	COG4251	negative regulation of phosphorylation
X969_RS12680	COG5001	Diguanylate cyclase
X969_RS12680	COG3706	GGDEF domain
X969_RS12680	COG2203	Gaf domain
X969_RS12700	COG0402	S-adenosylhomocysteine deaminase activity
X969_RS12705	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
X969_RS12720	COG1999	signal sequence binding
X969_RS12740	COG1929	Belongs to the glycerate kinase type-1 family
X969_RS12745	COG3835	regulator
X969_RS12750	COG2271	Major facilitator Superfamily
X969_RS12755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X969_RS12760	COG0667	Aldo Keto reductase
X969_RS12770	COG1902	pentaerythritol trinitrate reductase activity
X969_RS12775	COG3385	transposase activity
X969_RS12780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X969_RS12805	COG3135	benzoate transporter
X969_RS12810	COG3485	protocatechuate 3,4-dioxygenase
X969_RS12815	COG2814	Major facilitator Superfamily
X969_RS12885	COG0583	DNA-binding transcription factor activity
X969_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS12905	COG0174	glutamine synthetase
X969_RS12915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS12925	COG1760	l-serine dehydratase
X969_RS12930	COG0583	DNA-binding transcription factor activity
X969_RS12935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X969_RS12950	COG0438	transferase activity, transferring glycosyl groups
X969_RS12955	COG2990	Protein conserved in bacteria
X969_RS12960	COG1215	transferase activity, transferring glycosyl groups
X969_RS12965	COG1045	serine acetyltransferase
X969_RS13000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
X969_RS13025	COG1396	sequence-specific DNA binding
X969_RS13030	COG2031	fatty acid transporter
X969_RS13040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
X969_RS13050	COG0656	L-ascorbic acid biosynthetic process
X969_RS13055	COG0587	DNA-directed DNA polymerase activity
X969_RS13070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X969_RS13075	COG1280	lysine exporter protein (LysE YggA)
X969_RS13080	COG0583	DNA-binding transcription factor activity
X969_RS13085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X969_RS13100	COG1414	Transcriptional regulator
X969_RS13105	COG0154	amidase activity
X969_RS13115	COG1473	amidohydrolase
X969_RS13160	COG2369	cell adhesion
X969_RS13295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X969_RS13305	COG1609	Transcriptional regulator
X969_RS13430	COG3813	Protein conserved in bacteria
X969_RS13435	COG2197	response regulator
X969_RS13440	COG2205	protein histidine kinase activity
X969_RS13440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS13450	COG1609	Transcriptional regulator
X969_RS13455	COG3265	gluconokinase activity
X969_RS13470	COG2204	response regulator
X969_RS13475	COG2205	protein histidine kinase activity
X969_RS13480	COG5002	protein histidine kinase activity
X969_RS13485	COG1196	nuclear chromosome segregation
X969_RS13485	COG0739	heme binding
X969_RS13485	COG0741	lytic transglycosylase activity
X969_RS13495	COG1459	type II secretion system
X969_RS13500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS13525	COG4191	Histidine kinase
X969_RS13525	COG0784	Response regulator, receiver
X969_RS13545	COG2200	EAL domain
X969_RS13555	COG1253	flavin adenine dinucleotide binding
X969_RS13600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X969_RS13625	COG5001	Diguanylate cyclase
X969_RS13630	COG2205	protein histidine kinase activity
X969_RS13635	COG0745	RESPONSE REGULATOR receiver
X969_RS13640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS13650	COG0746	molybdenum cofactor guanylyltransferase activity
X969_RS13655	COG0318	PFAM AMP-dependent synthetase and ligase
X969_RS13680	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS13700	COG1132	(ABC) transporter
X969_RS13705	COG3284	Transcriptional regulator
X969_RS13740	COG2165	general secretion pathway protein
X969_RS13745	COG2165	general secretion pathway protein
X969_RS13775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X969_RS13780	COG2204	response regulator
X969_RS13855	COG3052	prosthetic group binding
X969_RS13875	COG1960	acyl-CoA dehydrogenase activity
X969_RS13880	COG0583	DNA-binding transcription factor activity
X969_RS13890	COG2384	SAM-dependent methyltransferase
X969_RS13900	COG0826	peptidase U32
X969_RS13915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X969_RS13920	COG0019	diaminopimelate decarboxylase activity
X969_RS13935	COG0583	DNA-binding transcription factor activity
X969_RS13950	COG0579	oxidoreductase
X969_RS13970	COG0307	riboflavin synthase, alpha
X969_RS13985	COG0113	porphobilinogen synthase activity
X969_RS13995	COG1113	amino acid transport
X969_RS14000	COG0579	oxidoreductase
X969_RS14010	COG1802	Transcriptional regulator
X969_RS14015	COG0745	RESPONSE REGULATOR receiver
X969_RS14020	COG5002	protein histidine kinase activity
X969_RS14020	COG3850	Histidine kinase
X969_RS14025	COG0215	cysteine-tRNA ligase activity
X969_RS14030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X969_RS14040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
X969_RS14045	COG2366	antibiotic biosynthetic process
X969_RS14085	COG0729	surface antigen
X969_RS14095	COG0708	Exodeoxyribonuclease III
X969_RS14100	COG1309	transcriptional regulator
X969_RS14105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X969_RS14115	COG3257	ureidoglycine aminohydrolase activity
X969_RS14125	COG0583	DNA-binding transcription factor activity
X969_RS14130	COG0405	Gamma-glutamyltransferase
X969_RS14145	COG2207	Transcriptional regulator
X969_RS14150	COG0789	Transcriptional regulator
X969_RS14160	COG1285	pathogenesis
X969_RS14170	COG0348	domain, Protein
X969_RS14175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS14185	COG0784	Response regulator, receiver
X969_RS14185	COG4191	Histidine kinase
X969_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS14195	COG1477	protein flavinylation
X969_RS14210	COG2814	Major facilitator Superfamily
X969_RS14215	COG1566	PFAM secretion protein HlyD family protein
X969_RS14220	COG1846	Transcriptional regulator
X969_RS14230	COG4566	intracellular signal transduction
X969_RS14245	COG1960	acyl-CoA dehydrogenase activity
X969_RS14255	COG2056	Na+-H+ antiporter family
X969_RS14260	COG0840	transmembrane signaling receptor activity
X969_RS14270	COG4176	ABC-type proline glycine betaine transport system permease component
X969_RS14300	COG1280	lysine exporter protein (LysE YggA)
X969_RS14310	COG0583	DNA-binding transcription factor activity
X969_RS14335	COG2801	Transposase and inactivated derivatives
X969_RS14360	COG4774	siderophore transport
X969_RS14365	COG3712	iron ion homeostasis
X969_RS14370	COG1595	DNA-templated transcription, initiation
X969_RS14425	COG0814	amino acid
X969_RS14460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS14465	COG1126	abc transporter atp-binding protein
X969_RS14470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X969_RS14475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X969_RS14480	COG2271	Major facilitator Superfamily
X969_RS14485	COG2721	sulfolactate sulfo-lyase activity
X969_RS14490	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS14495	COG2186	Transcriptional regulator
X969_RS14510	COG0583	DNA-binding transcription factor activity
X969_RS14550	COG1944	ATP diphosphatase activity
X969_RS14565	COG2010	Cytochrome c
X969_RS14595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X969_RS14605	COG4991	sh3 domain protein
X969_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS14625	COG1942	4-Oxalocrotonate Tautomerase
X969_RS14635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
X969_RS14645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X969_RS14650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X969_RS14655	COG1116	anion transmembrane transporter activity
X969_RS14670	COG2207	Transcriptional regulator
X969_RS14675	COG1959	2 iron, 2 sulfur cluster binding
X969_RS14685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X969_RS14690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X969_RS14695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X969_RS14705	COG2267	carboxylic ester hydrolase activity
X969_RS14710	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS14720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X969_RS14725	COG2186	Transcriptional regulator
X969_RS14735	COG0784	Response regulator, receiver
X969_RS14735	COG4191	Histidine kinase
X969_RS14740	COG1280	lysine exporter protein (LysE YggA)
X969_RS14755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X969_RS14760	COG0004	ammonium transporteR
X969_RS14765	COG0069	glutamate synthase activity
X969_RS14770	COG2218	PFAM glutamate synthase alpha subunit domain protein
X969_RS14775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
X969_RS14820	COG2855	membrane
X969_RS14825	COG1611	Belongs to the LOG family
X969_RS14840	COG3300	MHYT domain
X969_RS14840	COG5001	Diguanylate cyclase
X969_RS14855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X969_RS14860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
X969_RS14880	COG0656	L-ascorbic acid biosynthetic process
X969_RS14885	COG5001	Diguanylate cyclase
X969_RS14895	COG3485	protocatechuate 3,4-dioxygenase
X969_RS14900	COG4829	muconolactone delta-isomerase
X969_RS14905	COG4948	Mandelate Racemase Muconate Lactonizing
X969_RS14915	COG3048	D-serine ammonia-lyase activity
X969_RS14935	COG2249	NAD(P)H dehydrogenase (quinone) activity
X969_RS14950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
X969_RS14960	COG0045	succinate-CoA ligase (ADP-forming) activity
X969_RS14965	COG1960	acyl-CoA dehydrogenase activity
X969_RS14970	COG1024	Enoyl-CoA hydratase
X969_RS14975	COG0833	amino acid
X969_RS15000	COG1024	Enoyl-CoA hydratase
X969_RS15010	COG0577	efflux transmembrane transporter activity
X969_RS15040	COG0768	penicillin binding
X969_RS15070	COG2186	Transcriptional regulator
X969_RS15075	COG0277	FAD linked oxidase domain protein
X969_RS15080	COG0277	FAD linked oxidase domain protein
X969_RS15085	COG0247	lactate metabolic process
X969_RS15090	COG3193	protein, possibly involved in utilization of glycolate and propanediol
X969_RS15110	COG2807	transmembrane transport
X969_RS15115	COG0590	tRNA wobble adenosine to inosine editing
X969_RS15120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X969_RS15130	COG0183	Belongs to the thiolase family
X969_RS15135	COG1250	3-hydroxyacyl-CoA dehydrogenase
X969_RS15145	COG2205	protein histidine kinase activity
X969_RS15145	COG0784	Response regulator, receiver
X969_RS15145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS15145	COG2198	Histidine kinase
X969_RS15150	COG2205	protein histidine kinase activity
X969_RS15150	COG0784	Response regulator, receiver
X969_RS15150	COG5002	protein histidine kinase activity
X969_RS15160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X969_RS15165	COG0784	Response regulator, receiver
X969_RS15165	COG5002	protein histidine kinase activity
X969_RS15200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X969_RS15245	COG1686	Belongs to the peptidase S11 family
X969_RS15285	COG1121	(ABC) transporter
X969_RS15290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X969_RS15330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
X969_RS15345	COG0446	pyridine nucleotide-disulphide oxidoreductase
X969_RS15345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
X969_RS15355	COG0583	DNA-binding transcription factor activity
X969_RS15365	COG1741	Belongs to the pirin family
X969_RS15380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
X969_RS15390	COG1176	ABC-type spermidine putrescine transport system, permease component I
X969_RS15395	COG1177	transmembrane transport
X969_RS15400	COG3842	ATPase activity
X969_RS15405	COG2885	chlorophyll binding
X969_RS15410	COG0861	Integral membrane protein TerC family
X969_RS15425	COG1104	cysteine desulfurase activity
X969_RS15430	COG5654	RES domain protein
X969_RS15435	COG5642	Protein of unknown function (DUF2384)
X969_RS15445	COG0583	DNA-binding transcription factor activity
X969_RS15460	COG2814	Major facilitator Superfamily
X969_RS15470	COG1064	alcohol dehydrogenase
X969_RS15475	COG2207	Transcriptional regulator
X969_RS15495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X969_RS15505	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
X969_RS15510	COG3132	Protein of unknown function, DUF480
X969_RS15520	COG3634	alkyl hydroperoxide reductase activity
X969_RS15540	COG3258	Cytochrome c
X969_RS15545	COG2863	cytochrome
X969_RS15575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
X969_RS15585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X969_RS15590	COG0745	RESPONSE REGULATOR receiver
X969_RS15595	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
X969_RS15600	COG0784	Response regulator, receiver
X969_RS15600	COG4191	Histidine kinase
X969_RS15615	COG2259	Doxx family
X969_RS15625	COG1064	alcohol dehydrogenase
X969_RS15640	COG0583	DNA-binding transcription factor activity
X969_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS15650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X969_RS15695	COG0616	signal peptide processing
X969_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS15720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
X969_RS15745	COG0471	metal ion transport
X969_RS15745	COG0490	domain, Protein
X969_RS15750	COG2199	diguanylate cyclase activity
X969_RS15765	COG1335	isochorismatase
X969_RS15790	COG2233	PERMEase
X969_RS15810	COG2920	part of a sulfur-relay system
X969_RS15815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X969_RS15820	COG0435	Glutathione S-transferase
X969_RS15825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
X969_RS15825	COG1648	precorrin-2 dehydrogenase activity
X969_RS15830	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X969_RS15835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X969_RS15840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X969_RS15845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
X969_RS15850	COG1674	ftsk spoiiie
X969_RS15855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
X969_RS15860	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
X969_RS15865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
X969_RS15870	COG0542	response to heat
X969_RS15875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
X969_RS15880	COG1278	Cold shock
X969_RS15900	COG0482	sulfurtransferase activity
X969_RS15905	COG2915	High frequency lysogenization protein hflD homolog
X969_RS15915	COG2850	peptidyl-arginine hydroxylation
X969_RS15920	COG2153	protein acetylation
X969_RS15925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X969_RS15930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS15945	COG2816	NAD+ diphosphatase activity
X969_RS15950	COG1024	Enoyl-CoA hydratase
X969_RS15955	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
X969_RS15965	COG3040	lipid binding
X969_RS15970	COG1234	tRNA 3'-trailer cleavage
X969_RS15980	COG1953	Uracil, thiamine, allantoin
X969_RS15990	COG0493	'glutamate synthase
X969_RS16000	COG1309	transcriptional regulator
X969_RS16010	COG3387	PFAM Glycoside hydrolase 15-related
X969_RS16015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X969_RS16020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
X969_RS16045	COG0297	glycogen (starch) synthase activity
X969_RS16050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
X969_RS16055	COG1640	4-alpha-glucanotransferase
X969_RS16075	COG3568	Endonuclease Exonuclease Phosphatase
X969_RS16085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
X969_RS16090	COG0366	Alpha amylase catalytic
X969_RS16100	COG0318	PFAM AMP-dependent synthetase and ligase
X969_RS16105	COG1960	acyl-CoA dehydrogenase activity
X969_RS16110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X969_RS16130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X969_RS16150	COG0583	DNA-binding transcription factor activity
X969_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS16160	COG2271	Major facilitator Superfamily
X969_RS16170	COG3958	Transketolase
X969_RS16175	COG1126	abc transporter atp-binding protein
X969_RS16180	COG0765	amino acid transport
X969_RS16185	COG0765	amino acid transport
X969_RS16190	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
X969_RS16210	COG0840	transmembrane signaling receptor activity
X969_RS16240	COG3436	PFAM IS66 Orf2 family protein
X969_RS16280	COG0322	excinuclease ABC activity
X969_RS16305	COG0306	phosphate transporter
X969_RS16310	COG0625	glutathione transferase activity
X969_RS16315	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
X969_RS16315	COG2050	protein possibly involved in aromatic compounds catabolism
X969_RS16320	COG1113	amino acid transport
X969_RS16325	COG0583	DNA-binding transcription factor activity
X969_RS16330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X969_RS16345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X969_RS16350	COG0659	secondary active sulfate transmembrane transporter activity
X969_RS16380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X969_RS16385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X969_RS16390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X969_RS16390	COG0649	NAD binding
X969_RS16405	COG1034	ATP synthesis coupled electron transport
X969_RS16410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
X969_RS16415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X969_RS16425	COG0713	ATP synthesis coupled electron transport
X969_RS16440	COG1007	ATP synthesis coupled electron transport
X969_RS16475	COG0431	NADPH-dependent FMN reductase
X969_RS16495	COG0328	RNA-DNA hybrid ribonuclease activity
X969_RS16505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X969_RS16510	COG0741	lytic transglycosylase activity
X969_RS16510	COG1388	LysM domain
X969_RS16515	COG4166	transmembrane transport
X969_RS16520	COG4166	transmembrane transport
X969_RS16525	COG4174	ABC transporter (Permease)
X969_RS16530	COG4239	(ABC) transporter, permease
X969_RS16535	COG4172	Belongs to the ABC transporter superfamily
X969_RS16555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X969_RS16560	COG0583	DNA-binding transcription factor activity
X969_RS16580	COG0745	RESPONSE REGULATOR receiver
X969_RS16585	COG2205	protein histidine kinase activity
X969_RS16590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
X969_RS16600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
X969_RS16610	COG0628	permease
X969_RS16640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
X969_RS16655	COG4999	Histidine kinase
X969_RS16655	COG3437	response regulator, receiver
X969_RS16655	COG3850	Histidine kinase
X969_RS16655	COG2205	protein histidine kinase activity
X969_RS16660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
X969_RS16675	COG1741	Belongs to the pirin family
X969_RS16685	COG0326	Molecular chaperone. Has ATPase activity
X969_RS16720	COG0045	succinate-CoA ligase (ADP-forming) activity
X969_RS16725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X969_RS16745	COG1053	succinate dehydrogenase
X969_RS16750	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
X969_RS16755	COG2009	succinate dehydrogenase
X969_RS16765	COG3385	transposase activity
X969_RS16785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS16790	COG2885	chlorophyll binding
X969_RS16790	COG3047	cAMP biosynthetic process
X969_RS16835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS16840	COG1136	(ABC) transporter
X969_RS16840	COG0577	efflux transmembrane transporter activity
X969_RS16865	COG0657	acetylesterase activity
X969_RS16880	COG0642	Histidine kinase
X969_RS16900	COG2801	Transposase and inactivated derivatives
X969_RS16910	COG3328	transposase activity
X969_RS16930	COG2010	Cytochrome c
X969_RS16950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X969_RS16975	COG3039	Transposase
X969_RS17005	COG3123	guanosine phosphorylase activity
X969_RS17015	COG3278	Belongs to the heme-copper respiratory oxidase family
X969_RS17030	COG2010	Cytochrome c
X969_RS17035	COG3278	Belongs to the heme-copper respiratory oxidase family
X969_RS17050	COG2010	Cytochrome c
X969_RS17055	COG0348	domain, Protein
X969_RS17065	COG2217	Heavy metal translocating P-type atpase
X969_RS17085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X969_RS17090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X969_RS17095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
X969_RS17100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
X969_RS17105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X969_RS17125	COG0789	Transcriptional regulator
X969_RS17170	COG3617	BRO family, N-terminal domain
X969_RS17185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
X969_RS17190	COG3115	cell septum assembly
X969_RS17220	COG0402	S-adenosylhomocysteine deaminase activity
X969_RS17225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X969_RS17235	COG2252	PERMEase
X969_RS17260	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
X969_RS17270	COG2233	PERMEase
X969_RS17285	COG2354	Protein conserved in bacteria
X969_RS17300	COG3960	tartronate-semialdehyde synthase activity
X969_RS17305	COG3622	Belongs to the hyi family
X969_RS17310	COG2084	Dehydrogenase
X969_RS17320	COG0469	pyruvate kinase activity
X969_RS17330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X969_RS17340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X969_RS17340	COG0116	Belongs to the methyltransferase superfamily
X969_RS17350	COG1522	sequence-specific DNA binding
X969_RS17355	COG1953	Uracil, thiamine, allantoin
X969_RS17390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X969_RS17425	COG1138	Cytochrome C-type biogenesis protein
X969_RS17430	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
X969_RS17450	COG4133	protoheme IX ABC transporter activity
X969_RS17465	COG2257	FlhB HrpN YscU SpaS Family
X969_RS17470	COG2207	Transcriptional regulator
X969_RS17520	COG0835	chemotaxis
X969_RS17530	COG1192	Involved in chromosome partitioning
X969_RS17535	COG1360	Flagellar Motor Protein
X969_RS17540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
X969_RS17545	COG2201	protein-glutamate methylesterase activity
X969_RS17550	COG0643	Histidine kinase
X969_RS17550	COG2198	Histidine kinase
X969_RS17550	COG0784	Response regulator, receiver
X969_RS17555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
X969_RS17580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X969_RS17595	COG1987	bacterial-type flagellum assembly
X969_RS17635	COG0745	RESPONSE REGULATOR receiver
X969_RS17645	COG2882	bacterial-type flagellum organization
X969_RS17670	COG1677	Flagellar hook-basal body complex protein FliE
X969_RS17720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X969_RS17740	COG1706	bacterial-type flagellum-dependent cell motility
X969_RS17745	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
X969_RS17755	COG4787	bacterial-type flagellum-dependent cell motility
X969_RS17780	COG1815	bacterial-type flagellum-dependent cell motility
X969_RS17785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X969_RS17790	COG0784	Response regulator, receiver
X969_RS17790	COG0835	chemotaxis
X969_RS17810	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
X969_RS17815	COG0477	Major facilitator Superfamily
X969_RS17825	COG1522	sequence-specific DNA binding
X969_RS17830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
X969_RS17835	COG0022	dehydrogenase e1 component
X969_RS17845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X969_RS17850	COG3706	GGDEF domain
X969_RS17885	COG2239	Acts as a magnesium transporter
X969_RS17910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X969_RS17915	COG0527	aspartate kinase activity
X969_RS17920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X969_RS17930	COG2988	succinylglutamate desuccinylase activity
X969_RS17940	COG3724	N-succinylarginine dihydrolase activity
X969_RS17945	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS17960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X969_RS17985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS17990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X969_RS18010	COG2154	pterin-4-alpha-carbinolamine dehydratase
X969_RS18025	COG0247	lactate metabolic process
X969_RS18025	COG0277	FAD linked oxidase domain protein
X969_RS18040	COG2948	multi-organism process
X969_RS18055	COG3846	protein secretion by the type IV secretion system
X969_RS18070	COG3451	type IV secretory pathway VirB4
X969_RS18080	COG3838	Conjugal transfer protein Trbc
X969_RS18085	COG4962	Type ii secretion system protein e
X969_RS18110	COG0583	DNA-binding transcription factor activity
X969_RS18115	COG1846	Transcriptional regulator
X969_RS18120	COG2814	Major facilitator Superfamily
X969_RS18155	COG4959	Type IV secretory pathway protease TraF
X969_RS18170	COG1192	Involved in chromosome partitioning
X969_RS18255	COG4804	nuclease activity
X969_RS18265	COG1113	amino acid transport
X969_RS18275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
X969_RS18285	COG0009	L-threonylcarbamoyladenylate synthase
X969_RS18290	COG0613	PHP domain protein
X969_RS18295	COG2917	probably involved in intracellular septation
X969_RS18300	COG2350	Protein conserved in bacteria
X969_RS18305	COG0745	RESPONSE REGULATOR receiver
X969_RS18320	COG0778	Nitroreductase
X969_RS18325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X969_RS18345	COG2207	Transcriptional regulator
X969_RS18360	COG1752	Esterase of the alpha-beta hydrolase superfamily
X969_RS18370	COG0514	ATP-dependent DNA helicase (RecQ)
X969_RS18380	COG2832	Protein of unknown function (DUF454)
X969_RS18400	COG0840	transmembrane signaling receptor activity
X969_RS18415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X969_RS18420	COG0583	DNA-binding transcription factor activity
X969_RS18430	COG0697	spore germination
X969_RS18450	COG0513	Belongs to the DEAD box helicase family
X969_RS18455	COG0668	transmembrane transport
X969_RS18465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
X969_RS18475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
X969_RS18500	COG1132	(ABC) transporter
X969_RS18510	COG2188	Transcriptional regulator
X969_RS18520	COG1643	Atp-dependent helicase
X969_RS18525	COG0174	glutamine synthetase
X969_RS18530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS18535	COG0318	PFAM AMP-dependent synthetase and ligase
X969_RS18540	COG0318	PFAM AMP-dependent synthetase and ligase
X969_RS18545	COG2267	carboxylic ester hydrolase activity
X969_RS18550	COG2030	dehydratase
X969_RS18555	COG4941	Belongs to the sigma-70 factor family
X969_RS18565	COG3795	YCII-related domain
X969_RS18585	COG0242	peptide deformylase activity
X969_RS18590	COG1295	ribonuclease BN
X969_RS18615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
X969_RS18710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X969_RS18730	COG1984	allophanate hydrolase subunit 2
X969_RS18735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X969_RS18740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
X969_RS18745	COG2814	Major facilitator Superfamily
X969_RS18760	COG0121	glutamine amidotransferase
X969_RS18800	COG2983	Belongs to the UPF0260 family
X969_RS18810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X969_RS18815	COG3100	YcgL domain-containing protein
X969_RS18825	COG2194	sulfuric ester hydrolase activity
X969_RS18840	COG0626	cystathionine gamma-synthase activity
X969_RS18845	COG1522	sequence-specific DNA binding
X969_RS18850	COG0243	molybdopterin cofactor binding
X969_RS18855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X969_RS18860	COG3781	membrane
X969_RS18865	COG0521	Mo-molybdopterin cofactor biosynthetic process
X969_RS18880	COG0531	amino acid
X969_RS18885	COG3938	Belongs to the proline racemase family
X969_RS18890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X969_RS18905	COG1902	pentaerythritol trinitrate reductase activity
X969_RS18910	COG0640	Transcriptional regulator
X969_RS18925	COG0579	oxidoreductase
X969_RS18930	COG3938	Belongs to the proline racemase family
X969_RS18940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X969_RS18945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
X969_RS18955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X969_RS18960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
X969_RS18965	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
X969_RS18970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X969_RS18980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
X969_RS18990	COG0425	Belongs to the sulfur carrier protein TusA family
X969_RS18995	COG4783	chaperone-mediated protein folding
X969_RS19000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
X969_RS19010	COG0531	amino acid
X969_RS19015	COG0840	transmembrane signaling receptor activity
X969_RS19035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
X969_RS19040	COG0602	queuosine metabolic process
X969_RS19045	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
X969_RS19050	COG2885	chlorophyll binding
X969_RS19055	COG0823	Involved in the tonB-independent uptake of proteins
X969_RS19075	COG0824	Thioesterase
X969_RS19080	COG2255	four-way junction helicase activity
X969_RS19085	COG0632	four-way junction helicase activity
X969_RS19090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
X969_RS19095	COG0217	transcriptional regulatory protein
X969_RS19100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
X969_RS19115	COG0783	Belongs to the Dps family
X969_RS19125	COG2900	Belongs to the SlyX family
X969_RS19140	COG0442	prolyl-tRNA aminoacylation
X969_RS19150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X969_RS19175	COG3158	transport of potassium into the cell
X969_RS19180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X969_RS19205	COG0519	Catalyzes the synthesis of GMP from XMP
X969_RS19215	COG4807	Protein conserved in bacteria
X969_RS19225	COG1301	dicarboxylic acid transport
X969_RS19255	COG2205	protein histidine kinase activity
X969_RS19260	COG0745	RESPONSE REGULATOR receiver
X969_RS19270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
X969_RS19270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X969_RS19275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X969_RS19290	COG2801	Transposase and inactivated derivatives
X969_RS19295	COG2963	transposase activity
X969_RS19310	COG3436	PFAM IS66 Orf2 family protein
X969_RS19350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X969_RS19365	COG3088	subunit of a heme lyase
X969_RS19375	COG1138	Cytochrome C-type biogenesis protein
X969_RS19380	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
X969_RS19395	COG0596	Alpha beta hydrolase
X969_RS19400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X969_RS19415	COG3039	Transposase
X969_RS19435	COG4372	Transposase
X969_RS19445	COG3436	PFAM IS66 Orf2 family protein
X969_RS19460	COG0477	Major facilitator Superfamily
X969_RS19500	COG0579	oxidoreductase
X969_RS19560	COG0583	DNA-binding transcription factor activity
X969_RS19570	COG0625	glutathione transferase activity
X969_RS19575	COG3318	Belongs to the UPF0149 family
X969_RS19575	COG3012	SEC-C Motif Domain Protein
X969_RS19580	COG0252	asparaginase activity
X969_RS19590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X969_RS19620	COG2116	formate transmembrane transporter activity
X969_RS19630	COG3706	GGDEF domain
X969_RS19635	COG5001	Diguanylate cyclase
X969_RS19635	COG3300	MHYT domain
X969_RS19645	COG0583	DNA-binding transcription factor activity
X969_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS19665	COG1289	transmembrane transporter activity
X969_RS19685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X969_RS19740	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
X969_RS19745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
X969_RS19760	COG0259	pyridoxamine-phosphate oxidase activity
X969_RS19765	COG2885	chlorophyll binding
X969_RS19780	COG1199	ATP-dependent helicase activity
X969_RS19815	COG3012	SEC-C Motif Domain Protein
X969_RS19820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X969_RS19860	COG0653	protein targeting
X969_RS19865	COG2814	Major facilitator Superfamily
X969_RS19870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS19875	COG2366	antibiotic biosynthetic process
X969_RS19880	COG1793	dna ligase
X969_RS19880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
X969_RS19885	COG1793	dna ligase
X969_RS19895	COG1201	RNA secondary structure unwinding
X969_RS19910	COG0717	Belongs to the dCTP deaminase family
X969_RS19915	COG1278	Cold shock
X969_RS19920	COG0489	protein tyrosine kinase activity
X969_RS19925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X969_RS19925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X969_RS19940	COG4659	FMN binding
X969_RS19950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X969_RS19960	COG2197	response regulator
X969_RS19970	COG0137	argininosuccinate synthase activity
X969_RS19980	COG0418	dihydroorotase activity
X969_RS19985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X969_RS19990	COG0450	alkyl hydroperoxide reductase
X969_RS20010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
X969_RS20015	COG0243	molybdopterin cofactor binding
X969_RS20020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X969_RS20025	COG3842	ATPase activity
X969_RS20030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
X969_RS20040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X969_RS20060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS20065	COG0765	amino acid transport
X969_RS20070	COG0765	amino acid transport
X969_RS20075	COG1126	abc transporter atp-binding protein
X969_RS20095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
X969_RS20100	COG0583	DNA-binding transcription factor activity
X969_RS20105	COG0494	nUDIX hydrolase
X969_RS20110	COG1201	RNA secondary structure unwinding
X969_RS20120	COG0069	glutamate synthase activity
X969_RS20125	COG1113	amino acid transport
X969_RS20135	COG1695	Transcriptional regulator
X969_RS20140	COG2375	cellular response to nickel ion
X969_RS20150	COG4628	conserved protein (DUF2132)
X969_RS20155	COG4206	TonB-dependent receptor
X969_RS20170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
X969_RS20180	COG2226	methyltransferase
X969_RS20185	COG0500	methyltransferase
X969_RS20200	COG0642	Histidine kinase
X969_RS20210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
X969_RS20215	COG1381	Involved in DNA repair and RecF pathway recombination
X969_RS20220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X969_RS20225	COG0571	ribonuclease III activity
X969_RS20230	COG0681	Belongs to the peptidase S26 family
X969_RS20235	COG0481	GTPase activity
X969_RS20245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X969_RS20275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
X969_RS20280	COG0354	folic acid binding
X969_RS20320	COG3180	Ammonia monooxygenase
X969_RS20325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X969_RS20385	COG4191	Histidine kinase
X969_RS20395	COG0477	Major facilitator Superfamily
X969_RS20425	COG2207	Transcriptional regulator
X969_RS20435	COG0583	DNA-binding transcription factor activity
X969_RS20440	COG2910	NAD(P)H-binding
X969_RS20455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
X969_RS20460	COG0477	Major facilitator Superfamily
X969_RS20465	COG1309	transcriptional regulator
X969_RS20470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS20495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X969_RS20500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
X969_RS20505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
X969_RS20510	COG0477	Major facilitator Superfamily
X969_RS20515	COG0183	Belongs to the thiolase family
X969_RS20520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
X969_RS20525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
X969_RS20530	COG2814	Major facilitator Superfamily
X969_RS20535	COG1414	Transcriptional regulator
X969_RS20545	COG0306	phosphate transporter
X969_RS20550	COG0433	COG0433 Predicted ATPase
X969_RS20555	COG0840	transmembrane signaling receptor activity
X969_RS20575	COG0788	formyltetrahydrofolate deformylase activity
X969_RS20585	COG2925	Exonuclease
X969_RS20600	COG0469	pyruvate kinase activity
X969_RS20615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X969_RS20615	COG3153	acetyltransferase
X969_RS20630	COG0693	protein deglycase activity
X969_RS20635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X969_RS20680	COG1902	pentaerythritol trinitrate reductase activity
X969_RS20690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X969_RS20695	COG0583	DNA-binding transcription factor activity
X969_RS20705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
X969_RS20710	COG3622	Belongs to the hyi family
X969_RS20750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS20755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X969_RS20765	COG3642	lipopolysaccharide core region biosynthetic process
X969_RS20790	COG0459	protein refolding
X969_RS20795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X969_RS20830	COG0668	transmembrane transport
X969_RS20835	COG1666	GTP binding
X969_RS20850	COG2096	Adenosyltransferase
X969_RS20855	COG0352	thiamine-phosphate diphosphorylase activity
X969_RS20865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
X969_RS20870	COG0653	protein targeting
X969_RS20880	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
X969_RS20885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
X969_RS20900	COG1181	Belongs to the D-alanine--D-alanine ligase family
X969_RS20905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X969_RS20910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
X969_RS20915	COG0772	Belongs to the SEDS family
X969_RS20920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
X969_RS20925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X969_RS20930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X969_RS20935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X969_RS20950	COG0275	rRNA processing
X969_RS20955	COG2001	Belongs to the MraZ family
X969_RS20965	COG3107	peptidoglycan biosynthetic process
X969_RS20970	COG0792	nuclease activity
X969_RS20975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
X969_RS20980	COG2823	Periplasmic or secreted lipoprotein
X969_RS20990	COG2969	positive regulation of protein catabolic process
X969_RS20995	COG0625	glutathione transferase activity
X969_RS21000	COG2857	Cytochrome c1
X969_RS21005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
X969_RS21010	COG0723	plastoquinol--plastocyanin reductase activity
X969_RS21015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X969_RS21020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
X969_RS21025	COG0667	Aldo Keto reductase
X969_RS21035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
X969_RS21040	COG0180	Tryptophanyl-tRNA synthetase
X969_RS21060	COG1522	sequence-specific DNA binding
X969_RS21070	COG0175	sulfate reduction
X969_RS21080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X969_RS21085	COG1126	abc transporter atp-binding protein
X969_RS21090	COG0765	amino acid transport
X969_RS21095	COG4597	amino acid ABC transporter
X969_RS21100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS21105	COG0400	carboxylic ester hydrolase activity
X969_RS21110	COG0513	Belongs to the DEAD box helicase family
X969_RS21120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
X969_RS21125	COG0315	cyclic pyranopterin monophosphate synthase activity
X969_RS21130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
X969_RS21140	COG3022	response to hydroperoxide
X969_RS21145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
X969_RS21150	COG1215	transferase activity, transferring glycosyl groups
X969_RS21155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS21160	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
X969_RS21170	COG3420	alginic acid biosynthetic process
X969_RS21185	COG1696	Membrane protein involved in D-alanine export
X969_RS21200	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
X969_RS21200	COG0662	Cupin 2, conserved barrel domain protein
X969_RS21210	COG0300	oxidoreductase activity
X969_RS21215	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS21245	COG1566	PFAM secretion protein HlyD family protein
X969_RS21265	COG0583	DNA-binding transcription factor activity
X969_RS21270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X969_RS21285	COG2207	Transcriptional regulator
X969_RS21285	COG3708	Transcriptional regulator
X969_RS21360	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
X969_RS21370	COG1028	Short-chain dehydrogenase reductase Sdr
X969_RS21375	COG0596	Alpha beta hydrolase
X969_RS21380	COG1346	cytolysis
X969_RS21385	COG1380	Effector of murein hydrolase LrgA
X969_RS21390	COG0583	DNA-binding transcription factor activity
X969_RS21400	COG1366	Belongs to the anti-sigma-factor antagonist family
X969_RS21440	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
X969_RS21460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
X969_RS21470	COG0523	cobalamin synthesis protein
X969_RS21475	COG2879	small protein
X969_RS21480	COG1966	Carbon starvation protein
X969_RS21490	COG2233	PERMEase
X969_RS21500	COG1970	mechanosensitive ion channel activity
X969_RS21510	COG2197	response regulator
X969_RS21515	COG2813	Specifically methylates the guanine in position
X969_RS21525	COG1294	oxidase, subunit
X969_RS21530	COG1271	oxidase subunit
X969_RS21540	COG2252	PERMEase
X969_RS21545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
X969_RS21550	COG3485	protocatechuate 3,4-dioxygenase
X969_RS21555	COG3485	protocatechuate 3,4-dioxygenase
X969_RS21560	COG2321	neutral zinc metallopeptidase
X969_RS21565	COG0840	transmembrane signaling receptor activity
X969_RS21575	COG0583	DNA-binding transcription factor activity
X969_RS21580	COG2249	NAD(P)H dehydrogenase (quinone) activity
X969_RS21600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
X969_RS21605	COG2267	carboxylic ester hydrolase activity
X969_RS21610	COG2453	phosphatase
X969_RS21610	COG0671	phosphoesterase, PA-phosphatase related
X969_RS21625	COG4589	Belongs to the CDS family
X969_RS21645	COG0110	maltose O-acetyltransferase activity
X969_RS21690	COG2199	diguanylate cyclase activity
X969_RS21700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X969_RS21705	COG1074	ATP-dependent DNA helicase activity
X969_RS21710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
X969_RS21730	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
X969_RS21735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X969_RS21740	COG1183	phosphatidylcholine synthase activity
X969_RS21745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
X969_RS21755	COG0028	Belongs to the TPP enzyme family
X969_RS21760	COG3098	single-species biofilm formation
X969_RS21770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X969_RS21790	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
X969_RS21795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X969_RS21800	COG4558	Periplasmic binding protein
X969_RS21810	COG1489	DNA binding
X969_RS21815	COG0436	Aminotransferase
X969_RS21825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X969_RS21835	COG4191	Histidine kinase
X969_RS21845	COG0617	tRNA 3'-terminal CCA addition
X969_RS21855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
X969_RS21860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
X969_RS21875	COG0166	Belongs to the GPI family
X969_RS21880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X969_RS21905	COG2823	Periplasmic or secreted lipoprotein
X969_RS21910	COG1185	polyribonucleotide nucleotidyltransferase activity
X969_RS21915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
X969_RS21920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X969_RS21925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
X969_RS21930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
X969_RS21935	COG0195	Participates in both transcription termination and antitermination
X969_RS21940	COG0779	Required for maturation of 30S ribosomal subunits
X969_RS21955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X969_RS21960	COG0149	triose-phosphate isomerase activity
X969_RS21965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X969_RS21970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
X969_RS21980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
X969_RS21995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X969_RS22000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X969_RS22005	COG0505	Belongs to the CarA family
X969_RS22010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
X969_RS22015	COG0484	heat shock protein binding
X969_RS22020	COG0443	Heat shock 70 kDa protein
X969_RS22025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
X969_RS22030	COG0497	DNA recombination
X969_RS22035	COG0735	belongs to the Fur family
X969_RS22040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X969_RS22050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
X969_RS22060	COG1620	l-lactate permease
X969_RS22065	COG1304	FMN binding
X969_RS22115	COG0604	alcohol dehydrogenase
X969_RS22115	COG3321	synthase
X969_RS22120	COG0546	phosphoglycolate phosphatase activity
X969_RS22125	COG1946	Acyl-CoA thioesterase
X969_RS22140	COG0123	including yeast histone deacetylase and acetoin utilization protein
X969_RS22150	COG0513	Belongs to the DEAD box helicase family
X969_RS22155	COG0697	spore germination
X969_RS22160	COG1522	sequence-specific DNA binding
X969_RS22165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X969_RS22175	COG3416	Protein conserved in bacteria
X969_RS22190	COG1643	Atp-dependent helicase
X969_RS22210	COG1522	sequence-specific DNA binding
X969_RS22225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
X969_RS22230	COG1960	acyl-CoA dehydrogenase activity
X969_RS22245	COG3328	transposase activity
X969_RS22250	COG4999	Histidine kinase
X969_RS22250	COG3437	response regulator, receiver
X969_RS22250	COG3850	Histidine kinase
X969_RS22250	COG2205	protein histidine kinase activity
X969_RS22255	COG0351	phosphomethylpyrimidine kinase
X969_RS22260	COG0352	thiamine-phosphate diphosphorylase activity
X969_RS22265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
X969_RS22280	COG1702	phosphate starvation-inducible protein PhoH
X969_RS22285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
X969_RS22290	COG4535	Mg2 and Co2 transporter CorC
X969_RS22295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
X969_RS22310	COG0495	leucyl-tRNA aminoacylation
X969_RS22330	COG2951	lytic endotransglycosylase activity
X969_RS22335	COG1619	proteins homologs of microcin C7 resistance protein MccF
X969_RS22340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
X969_RS22345	COG0321	lipoyl(octanoyl) transferase activity
X969_RS22350	COG2921	Belongs to the UPF0250 family
X969_RS22355	COG1686	Belongs to the peptidase S11 family
X969_RS22365	COG2951	lytic endotransglycosylase activity
X969_RS22370	COG0772	Belongs to the SEDS family
X969_RS22375	COG0768	penicillin binding
X969_RS22380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
X969_RS22390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
X969_RS22395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
X969_RS22400	COG2094	Belongs to the DNA glycosylase MPG family
X969_RS22405	COG0586	Pfam SNARE associated Golgi protein
X969_RS22415	COG1346	cytolysis
X969_RS22430	COG2264	protein methyltransferase activity
X969_RS22440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X969_RS22450	COG0138	bifunctional purine biosynthesis protein purh
X969_RS22455	COG0151	Belongs to the GarS family
X969_RS22465	COG2095	MarC family integral membrane protein
X969_RS22495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X969_RS22505	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
X969_RS22520	COG0330	HflC and HflK could
X969_RS22545	COG4774	siderophore transport
X969_RS22555	COG1113	amino acid transport
X969_RS22575	COG0411	ABC transporter
X969_RS22590	COG0789	Transcriptional regulator
X969_RS22595	COG0484	heat shock protein binding
X969_RS22600	COG0443	Heat shock 70 kDa protein
X969_RS22620	COG0697	spore germination
X969_RS22625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
X969_RS22640	COG2982	Protein involved in outer membrane biogenesis
X969_RS22660	COG4221	oxidoreductase activity
X969_RS22690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
X969_RS22695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
X969_RS22710	COG1032	radical SAM domain protein
X969_RS22715	COG0305	Participates in initiation and elongation during chromosome replication
X969_RS22720	COG0359	binds to the 23S rRNA
X969_RS22730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
X969_RS22735	COG0360	Binds together with S18 to 16S ribosomal RNA
X969_RS22740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X969_RS22745	COG0557	exoribonuclease II activity
X969_RS22760	COG1840	ABC-type Fe3 transport system, periplasmic component
X969_RS22765	COG1178	ABC-type Fe3 transport system permease component
X969_RS22805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
X969_RS22810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
X969_RS22815	COG0330	HflC and HflK could
X969_RS22820	COG0330	HflC and HflK could
X969_RS22825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X969_RS22830	COG1923	regulation of RNA biosynthetic process
X969_RS22835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
X969_RS22840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X969_RS22845	COG0860	N-Acetylmuramoyl-L-alanine amidase
X969_RS22850	COG0802	atpase or kinase
X969_RS22855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
X969_RS22855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
X969_RS22865	COG2860	membrane
X969_RS22870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
X969_RS22875	COG1162	GTPase activity
X969_RS22885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
X969_RS22900	COG0688	phosphatidylethanolamine metabolic process
X969_RS22905	COG3830	Belongs to the UPF0237 family
X969_RS22905	COG0560	Phosphoserine phosphatase
X969_RS22925	COG3577	Aspartyl protease
X969_RS22940	COG3150	esterase
X969_RS22945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
X969_RS22955	COG0494	nUDIX hydrolase
X969_RS22970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
X969_RS22975	COG1538	Outer membrane efflux protein
X969_RS22980	COG1519	Transferase
X969_RS22985	COG0583	DNA-binding transcription factor activity
X969_RS23005	COG0667	Aldo Keto reductase
X969_RS23015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
X969_RS23015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X969_RS23020	COG1132	(ABC) transporter
X969_RS23035	COG0438	transferase activity, transferring glycosyl groups
X969_RS23060	COG0438	transferase activity, transferring glycosyl groups
X969_RS23065	COG2192	nodulation
X969_RS23070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
X969_RS23075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X969_RS23080	COG0506	proline dehydrogenase activity
X969_RS23080	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
X969_RS23080	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
X969_RS23095	COG1960	acyl-CoA dehydrogenase activity
X969_RS23105	COG0312	modulator of DNA gyrase
X969_RS23110	COG0477	Major facilitator Superfamily
X969_RS23115	COG0513	Belongs to the DEAD box helicase family
X969_RS23120	COG2081	HI0933 family
X969_RS23125	COG1289	transmembrane transporter activity
X969_RS23135	COG2153	protein acetylation
X969_RS23145	COG1451	nucleotide metabolic process
X969_RS23150	COG5001	Diguanylate cyclase
X969_RS23150	COG3300	MHYT domain
X969_RS23170	COG0126	phosphoglycerate kinase activity
X969_RS23175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X969_RS23180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
X969_RS23185	COG0640	Transcriptional regulator
X969_RS23190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
X969_RS23195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
X969_RS23235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
X969_RS23240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
X969_RS23255	COG0513	Belongs to the DEAD box helicase family
X969_RS23260	COG2353	YceI-like domain
X969_RS23265	COG3038	cytochrome b561
X969_RS23285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X969_RS23290	COG1272	protein, Hemolysin III
X969_RS23300	COG0643	Histidine kinase
X969_RS23300	COG0784	Response regulator, receiver
X969_RS23300	COG2198	Histidine kinase
X969_RS23325	COG0189	ligase activity
X969_RS23335	COG1678	Uncharacterized ACR, COG1678
X969_RS23340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
X969_RS23345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X969_RS23350	COG0540	Belongs to the ATCase OTCase family
X969_RS23355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
X969_RS23360	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
X969_RS23365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
X969_RS23410	COG2226	methyltransferase
X969_RS23420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
X969_RS23425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
X969_RS23430	COG0140	phosphoribosyl-ATP diphosphatase activity
X969_RS23435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X969_RS23455	COG0840	transmembrane signaling receptor activity
X969_RS23465	COG1126	abc transporter atp-binding protein
X969_RS23470	COG0765	amino acid transport
X969_RS23480	COG2943	transferase activity, transferring hexosyl groups
X969_RS23485	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
X969_RS23490	COG1490	D-aminoacyl-tRNA deacylase activity
X969_RS23510	COG1228	amidohydrolase
X969_RS23520	COG2986	histidine ammonia-lyase
X969_RS23525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
X969_RS23535	COG2188	Transcriptional regulator
X969_RS23540	COG0402	S-adenosylhomocysteine deaminase activity
X969_RS23560	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
X969_RS23565	COG0058	SHG alpha-glucan phosphorylase activity
X969_RS23580	COG1217	gtp-binding protein TYPA
X969_RS23585	COG0301	tRNA thio-modification
X969_RS23585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X969_RS23600	COG3852	Histidine kinase
X969_RS23620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
X969_RS23630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X969_RS23635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
X969_RS23640	COG4942	peptidase
X969_RS23645	COG0793	Belongs to the peptidase S41A family
X969_RS23650	COG2861	carbohydrate metabolic process
X969_RS23660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X969_RS23665	COG1309	transcriptional regulator
X969_RS23670	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS23675	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
X969_RS23680	COG3263	regulation of cellular component size
X969_RS23685	COG3264	Mechanosensitive ion channel
X969_RS23685	COG1196	nuclear chromosome segregation
X969_RS23690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
X969_RS23695	COG3118	belongs to the thioredoxin family
X969_RS23700	COG1192	Involved in chromosome partitioning
X969_RS23705	COG0583	DNA-binding transcription factor activity
X969_RS23720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
X969_RS23725	COG0493	'glutamate synthase
X969_RS23730	COG0070	glutamate synthase
X969_RS23730	COG0069	glutamate synthase activity
X969_RS23730	COG0067	glutamate synthase
X969_RS23740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
X969_RS23745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
X969_RS23775	COG0281	malic enzyme
X969_RS23785	COG0254	rRNA binding
X969_RS23790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X969_RS23795	COG0018	arginyl-trna synthetase
X969_RS23810	COG0791	NLP P60 protein
X969_RS23835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
X969_RS23840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
X969_RS23840	COG2813	Specifically methylates the guanine in position
X969_RS23850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X969_RS23855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X969_RS23865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
X969_RS23870	COG2022	thiamine diphosphate biosynthetic process
X969_RS23880	COG2363	Small membrane protein
X969_RS23885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X969_RS23895	COG2177	Part of the ABC transporter FtsEX involved in
X969_RS23900	COG2884	Cell division ATP-binding protein ftsE
X969_RS23905	COG0552	protein localization to endoplasmic reticulum
X969_RS23910	COG0612	Peptidase, M16
X969_RS23915	COG0612	Peptidase, M16
X969_RS23920	COG0742	ribosomal rna small subunit methyltransferase
X969_RS23930	COG0612	Peptidase, M16
X969_RS23960	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
X969_RS23965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
X969_RS23970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
X969_RS23975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
X969_RS23985	COG0693	protein deglycase activity
X969_RS23995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
X969_RS24000	COG0129	dihydroxy-acid dehydratase activity
X969_RS24005	COG0583	DNA-binding transcription factor activity
X969_RS24020	COG1823	symporter activity
X969_RS24035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
X969_RS24045	COG1840	ABC-type Fe3 transport system, periplasmic component
X969_RS24050	COG1178	ABC-type Fe3 transport system permease component
X969_RS24055	COG3842	ATPase activity
X969_RS24070	COG0789	Transcriptional regulator
X969_RS24075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X969_RS24080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
X969_RS24085	COG0730	response to heat
X969_RS24095	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
X969_RS24100	COG0494	nUDIX hydrolase
X969_RS24115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X969_RS24120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
X969_RS24125	COG3204	pilus organization
X969_RS24130	COG3204	pilus organization
X969_RS24135	COG0179	Fumarylacetoacetate (FAA) hydrolase
X969_RS24140	COG0277	FAD linked oxidase domain protein
X969_RS24145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X969_RS24160	COG1683	Conserved Protein
X969_RS24205	COG2267	carboxylic ester hydrolase activity
X969_RS24225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
X969_RS24230	COG4208	sulfate ABC transporter
X969_RS24240	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
X969_RS24250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X969_RS24275	COG1177	transmembrane transport
X969_RS24280	COG1176	ABC-type spermidine putrescine transport system, permease component I
X969_RS24285	COG3842	ATPase activity
X969_RS24305	COG0174	glutamine synthetase
X969_RS24315	COG0174	glutamine synthetase
X969_RS24320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
X969_RS24320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X969_RS24325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X969_RS24335	COG1522	sequence-specific DNA binding
X969_RS24345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X969_RS24355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X969_RS24355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
X969_RS24360	COG0509	glycine decarboxylation via glycine cleavage system
X969_RS24365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
X969_RS24370	COG1178	ABC-type Fe3 transport system permease component
X969_RS24380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X969_RS24390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X969_RS24395	COG0006	proline dipeptidase activity
X969_RS24400	COG3079	Belongs to the UPF0149 family
X969_RS24415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
X969_RS24425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS24430	COG0842	Transport permease protein
X969_RS24430	COG1129	ABC transporter
X969_RS24435	COG0842	Transport permease protein
X969_RS24460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
X969_RS24475	COG0248	Ppx GppA phosphatase
X969_RS24480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
X969_RS24495	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
X969_RS24500	COG1671	Belongs to the UPF0178 family
X969_RS24510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X969_RS24520	COG1965	Belongs to the frataxin family
X969_RS24530	COG0019	diaminopimelate decarboxylase activity
X969_RS24535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
X969_RS24545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
X969_RS24550	COG0546	phosphoglycolate phosphatase activity
X969_RS24560	COG0004	ammonium transporteR
X969_RS24565	COG0347	Belongs to the P(II) protein family
X969_RS24580	COG0606	chelatase, subunit chli
X969_RS24585	COG4566	intracellular signal transduction
X969_RS24590	COG4566	intracellular signal transduction
X969_RS24595	COG4191	Histidine kinase
X969_RS24600	COG1335	isochorismatase
X969_RS24625	COG1335	isochorismatase
X969_RS24630	COG0583	DNA-binding transcription factor activity
X969_RS24640	COG0477	Major facilitator Superfamily
X969_RS24660	COG1335	isochorismatase
X969_RS24670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS24675	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS24680	COG0583	DNA-binding transcription factor activity
X969_RS24685	COG5383	Protein conserved in bacteria
X969_RS24695	COG0534	Mate efflux family protein
X969_RS24710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X969_RS24715	COG0427	acetyl-CoA hydrolase
X969_RS24735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS24750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X969_RS24760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X969_RS24765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X969_RS24775	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS24785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
X969_RS24795	COG0747	negative chemotaxis
X969_RS24800	COG2003	Belongs to the UPF0758 family
X969_RS24805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
X969_RS24810	COG0756	dUTP diphosphatase activity
X969_RS24815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X969_RS24820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X969_RS24825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X969_RS24830	COG0708	Exodeoxyribonuclease III
X969_RS24840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
X969_RS24845	COG1561	YicC-like family, N-terminal region
X969_RS24850	COG0194	GDP metabolic process
X969_RS24860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X969_RS24865	COG0174	glutamine synthetase
X969_RS24875	COG1758	RNA polymerase activity
X969_RS24880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X969_RS24905	COG0848	biopolymer transport protein
X969_RS24915	COG0583	DNA-binding transcription factor activity
X969_RS24920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
X969_RS24950	COG3161	chorismate lyase activity
X969_RS24955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
X969_RS24975	COG1253	flavin adenine dinucleotide binding
X969_RS24980	COG0739	heme binding
X969_RS24995	COG0704	Plays a role in the regulation of phosphate uptake
X969_RS25000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X969_RS25005	COG0581	inorganic phosphate transmembrane transporter activity
X969_RS25020	COG0477	Major facilitator Superfamily
X969_RS25025	COG1607	acyl-coa hydrolase
X969_RS25060	COG0583	DNA-binding transcription factor activity
X969_RS25065	COG1027	Aspartate ammonia-lyase
X969_RS25105	COG0511	ligase activity, forming carbon-carbon bonds
X969_RS25105	COG5016	pyruvate
X969_RS25110	COG0439	Biotin carboxylase
X969_RS25115	COG0583	DNA-binding transcription factor activity
X969_RS25125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X969_RS25135	COG0210	DNA helicase
X969_RS25150	COG4651	solute:proton antiporter activity
X969_RS25150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X969_RS25155	COG1607	acyl-coa hydrolase
X969_RS25160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
X969_RS25170	COG0523	cobalamin synthesis protein
X969_RS25185	COG1469	GTP cyclohydrolase I activity
X969_RS25195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X969_RS25200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
X969_RS25205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X969_RS25235	COG2132	Multicopper oxidase
X969_RS25275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X969_RS25325	COG2963	transposase activity
X969_RS25330	COG2801	Transposase and inactivated derivatives
X969_RS25335	COG3039	Transposase
X969_RS25340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X969_RS25345	COG1349	DNA-binding transcription factor activity
X969_RS25350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
X969_RS25355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
X969_RS25360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
X969_RS25365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
X969_RS25370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
X969_RS25375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X969_RS25380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
X969_RS25390	COG0356	it plays a direct role in the translocation of protons across the membrane
X969_RS25395	COG3312	ion transport
X969_RS25400	COG1475	DNA binding
X969_RS25405	COG1192	Involved in chromosome partitioning
X969_RS25410	COG0357	Ribosomal RNA small subunit methyltransferase G
X969_RS25415	COG0445	tRNA wobble uridine modification
X969_RS25420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
X969_RS25425	COG0706	membrane insertase activity
X969_RS25435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X969_RS25440	COG0592	DNA-directed DNA polymerase activity
X969_RS25445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X969_RS25450	COG0187	DNA topoisomerase II activity
X969_RS25475	COG2433	Pfam Transposase IS66
X969_RS25500	COG0659	secondary active sulfate transmembrane transporter activity
X969_RS25505	COG0589	response to stress
X969_RS25515	COG2433	Pfam Transposase IS66
X969_RS25535	COG2433	Pfam Transposase IS66
X969_RS25550	COG2194	sulfuric ester hydrolase activity
X969_RS25555	COG3039	Transposase
X969_RS25560	COG2194	sulfuric ester hydrolase activity
X969_RS25610	COG0463	Glycosyl transferase, family 2
X969_RS25680	COG3436	PFAM IS66 Orf2 family protein
X969_RS25695	COG2963	transposase activity
X969_RS25700	COG2801	Transposase and inactivated derivatives
X969_RS25735	COG0477	Major facilitator Superfamily
X969_RS25745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
X969_RS25750	COG0751	glycine-tRNA ligase activity
X969_RS25755	COG0752	glycyl-tRNA synthetase alpha subunit
X969_RS25760	COG2818	Glycosylase
X969_RS25775	COG0569	domain protein
X969_RS25780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X969_RS25785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X969_RS25790	COG0242	peptide deformylase activity
X969_RS25795	COG0758	DNA mediated transformation
X969_RS25800	COG0009	L-threonylcarbamoyladenylate synthase
X969_RS25815	COG0408	coproporphyrinogen oxidase activity
X969_RS25820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X969_RS25825	COG0659	secondary active sulfate transmembrane transporter activity
X969_RS25835	COG3119	arylsulfatase activity
X969_RS25855	COG0159	tryptophan synthase activity
X969_RS25860	COG0133	tryptophan synthase activity
X969_RS25875	COG3360	Dodecin
X969_RS25885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X969_RS25890	COG1764	response to oxidative stress
X969_RS25920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
X969_RS25925	COG0339	signal peptide processing
X969_RS25930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
X969_RS25935	COG0339	signal peptide processing
X969_RS25950	COG0659	secondary active sulfate transmembrane transporter activity
X969_RS25960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X969_RS25965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X969_RS25970	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
X969_RS25985	COG3346	SURF1 family
X969_RS25995	COG1612	heme a metabolic process
X969_RS26000	COG0109	protoheme IX farnesyltransferase activity
X969_RS26015	COG2011	ABC-type metal ion transport system permease component
X969_RS26020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X969_RS26035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X969_RS26040	COG1121	(ABC) transporter
X969_RS26045	COG0735	belongs to the Fur family
X969_RS26050	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
X969_RS26070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
X969_RS26075	COG3245	cytochrome
X969_RS26085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X969_RS26100	COG3023	N-Acetylmuramoyl-L-alanine amidase
X969_RS26105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
X969_RS26110	COG5002	protein histidine kinase activity
X969_RS26115	COG2204	response regulator
X969_RS26140	COG1301	dicarboxylic acid transport
X969_RS26145	COG0700	Nucleoside recognition
X969_RS26160	COG1127	ABC transporter
X969_RS26165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
X969_RS26185	COG1283	sodium-dependent phosphate transmembrane transporter activity
X969_RS26190	COG0861	Integral membrane protein TerC family
X969_RS26195	COG2851	Citrate transporter
X969_RS26230	COG0427	acetyl-CoA hydrolase
X969_RS26250	COG0583	DNA-binding transcription factor activity
X969_RS26255	COG1960	acyl-CoA dehydrogenase activity
X969_RS26300	COG1802	Transcriptional regulator
X969_RS26310	COG5001	Diguanylate cyclase
X969_RS26310	COG3300	MHYT domain
X969_RS26315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X969_RS26325	COG3039	Transposase
X969_RS26340	COG2175	clavaminate synthase activity
X969_RS26355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X969_RS26380	COG1289	transmembrane transporter activity
X969_RS26390	COG1566	PFAM secretion protein HlyD family protein
X969_RS26410	COG0672	)-iron permease
X969_RS26425	COG0625	glutathione transferase activity
X969_RS26430	COG0165	Argininosuccinate lyase
X969_RS26440	COG0181	hydroxymethylbilane synthase activity
X969_RS26460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
X969_RS26490	COG0488	(ABC) transporter
X969_RS26495	COG1280	lysine exporter protein (LysE YggA)
X969_RS26550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
X969_RS26560	COG1136	(ABC) transporter
X969_RS26595	COG2188	Transcriptional regulator
X969_RS26600	COG1053	succinate dehydrogenase
X969_RS26615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X969_RS26640	COG1012	belongs to the aldehyde dehydrogenase family
X969_RS26645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
X969_RS26655	COG0745	RESPONSE REGULATOR receiver
X969_RS26660	COG2199	diguanylate cyclase activity
X969_RS26675	COG2011	ABC-type metal ion transport system permease component
X969_RS26680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
X969_RS26685	COG1464	Belongs to the NlpA lipoprotein family
X969_RS26710	COG1126	abc transporter atp-binding protein
X969_RS26715	COG0765	amino acid transport
X969_RS26720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X969_RS26725	COG1045	serine acetyltransferase
X969_RS26730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X969_RS26735	COG2175	clavaminate synthase activity
X969_RS26740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X969_RS26745	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
X969_RS26750	COG4521	taurine ABC transporter
X969_RS26760	COG0450	alkyl hydroperoxide reductase
X969_RS26765	COG0431	NADPH-dependent FMN reductase
X969_RS26770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X969_RS26775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X969_RS26780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X969_RS26785	COG1116	anion transmembrane transporter activity
X969_RS26800	COG2918	glutathione biosynthetic process
X969_RS26810	COG2183	response to ionizing radiation
X969_RS26825	COG0189	ligase activity
X969_RS26830	COG4067	protein conserved in archaea
X969_RS26830	COG0189	ligase activity
X969_RS26835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
X969_RS26845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
X969_RS26850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
X969_RS26865	COG0243	molybdopterin cofactor binding
X969_RS26870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
X969_RS26875	COG1652	LysM domain
X969_RS26880	COG1011	Hydrolase
X969_RS26885	COG0494	nUDIX hydrolase
X969_RS26890	COG1218	3'(2'),5'-bisphosphate nucleotidase
X969_RS26915	COG2957	Belongs to the agmatine deiminase family
X969_RS26930	COG0069	glutamate synthase activity
X969_RS26980	COG4215	(ABC) transporter
X969_RS27015	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
X969_RS27030	COG2223	nitrite transmembrane transporter activity
X969_RS27035	COG0131	Imidazoleglycerol-phosphate dehydratase
X969_RS27040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
X969_RS27050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
X969_RS27055	COG0107	imidazoleglycerol-phosphate synthase activity
X969_RS27060	COG4175	Glycine betaine
X969_RS27065	COG4176	ABC-type proline glycine betaine transport system permease component
X969_RS27075	COG1760	l-serine dehydratase
X969_RS27095	COG1250	3-hydroxyacyl-CoA dehydrogenase
X969_RS27100	COG3246	L-lysine catabolic process to acetate
X969_RS27150	COG1902	pentaerythritol trinitrate reductase activity
X969_RS27150	COG0446	pyridine nucleotide-disulphide oxidoreductase
X969_RS27155	COG2181	nitrate reductase activity
X969_RS27155	COG0247	lactate metabolic process
X969_RS27160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
X969_RS27180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X969_RS27180	COG1017	nitric oxide dioxygenase activity
X969_RS27200	COG0840	transmembrane signaling receptor activity
X969_RS27210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
X969_RS27245	COG1063	alcohol dehydrogenase
X969_RS27255	COG0531	amino acid
X969_RS27260	COG0204	Acyl-transferase
X969_RS27270	COG0745	RESPONSE REGULATOR receiver
X969_RS27275	COG2205	protein histidine kinase activity
X969_RS27280	COG4452	Inner membrane protein CreD
X969_RS27290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X969_RS27310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
X969_RS27325	COG0438	transferase activity, transferring glycosyl groups
X969_RS27400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X969_RS27410	COG0840	transmembrane signaling receptor activity