locus-tag	class	description
C4J97_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J97_RS00010	COG0592	DNA-directed DNA polymerase activity
C4J97_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J97_RS00020	COG0187	DNA topoisomerase II activity
C4J97_RS00030	COG0745	RESPONSE REGULATOR receiver
C4J97_RS00035	COG5002	protein histidine kinase activity
C4J97_RS00050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4J97_RS00055	COG0751	glycine-tRNA ligase activity
C4J97_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
C4J97_RS00065	COG2818	Glycosylase
C4J97_RS00080	COG0569	domain protein
C4J97_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4J97_RS00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J97_RS00095	COG0242	peptide deformylase activity
C4J97_RS00105	COG0758	DNA mediated transformation
C4J97_RS00110	COG0009	L-threonylcarbamoyladenylate synthase
C4J97_RS00120	COG0408	coproporphyrinogen oxidase activity
C4J97_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J97_RS00140	COG3119	arylsulfatase activity
C4J97_RS00145	COG0583	DNA-binding transcription factor activity
C4J97_RS00155	COG3734	2-keto-3-deoxy-galactonokinase
C4J97_RS00160	COG0800	Aldolase
C4J97_RS00165	COG4948	Mandelate Racemase Muconate Lactonizing
C4J97_RS00170	COG2271	Major facilitator Superfamily
C4J97_RS00180	COG0159	tryptophan synthase activity
C4J97_RS00200	COG3360	Dodecin
C4J97_RS00215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J97_RS00220	COG1764	response to oxidative stress
C4J97_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4J97_RS00250	COG0339	signal peptide processing
C4J97_RS00285	COG0659	secondary active sulfate transmembrane transporter activity
C4J97_RS00295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J97_RS00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J97_RS00305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4J97_RS00335	COG0109	protoheme IX farnesyltransferase activity
C4J97_RS00350	COG2011	ABC-type metal ion transport system permease component
C4J97_RS00355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J97_RS00370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J97_RS00375	COG1121	(ABC) transporter
C4J97_RS00380	COG0735	belongs to the Fur family
C4J97_RS00385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4J97_RS00405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4J97_RS00420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4J97_RS00435	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J97_RS00440	COG5002	protein histidine kinase activity
C4J97_RS00445	COG2204	response regulator
C4J97_RS00455	COG5487	UPF0391 membrane protein
C4J97_RS00465	COG1301	dicarboxylic acid transport
C4J97_RS00470	COG0700	Nucleoside recognition
C4J97_RS00485	COG1127	ABC transporter
C4J97_RS00490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J97_RS00500	COG0612	Peptidase, M16
C4J97_RS00505	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4J97_RS00510	COG0861	Integral membrane protein TerC family
C4J97_RS00515	COG2851	Citrate transporter
C4J97_RS00545	COG0427	acetyl-CoA hydrolase
C4J97_RS00565	COG0583	DNA-binding transcription factor activity
C4J97_RS00575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J97_RS00615	COG0840	transmembrane signaling receptor activity
C4J97_RS00620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J97_RS00645	COG5001	Diguanylate cyclase
C4J97_RS00645	COG3300	MHYT domain
C4J97_RS00665	COG2274	protein secretion by the type I secretion system
C4J97_RS00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS00675	COG2175	clavaminate synthase activity
C4J97_RS00745	COG1289	transmembrane transporter activity
C4J97_RS00770	COG5339	Protein conserved in bacteria
C4J97_RS00775	COG0457	Tetratricopeptide repeat
C4J97_RS00780	COG0726	polysaccharide deacetylase
C4J97_RS00780	COG1649	PFAM Uncharacterised BCR, COG1649
C4J97_RS00785	COG1215	transferase activity, transferring glycosyl groups
C4J97_RS00815	COG3210	domain, Protein
C4J97_RS00910	COG2304	oxidoreductase activity
C4J97_RS00915	COG1595	DNA-templated transcription, initiation
C4J97_RS00925	COG1063	alcohol dehydrogenase
C4J97_RS00950	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS00955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J97_RS00960	COG2199	diguanylate cyclase activity
C4J97_RS00980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J97_RS00990	COG4208	sulfate ABC transporter
C4J97_RS00995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4J97_RS01010	COG2351	hydroxyisourate hydrolase activity
C4J97_RS01040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J97_RS01045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS01070	COG4771	TonB-dependent receptor
C4J97_RS01075	COG2807	transmembrane transport
C4J97_RS01080	COG0583	DNA-binding transcription factor activity
C4J97_RS01120	COG0765	amino acid transport
C4J97_RS01125	COG0765	amino acid transport
C4J97_RS01130	COG1126	abc transporter atp-binding protein
C4J97_RS01135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS01170	COG2011	ABC-type metal ion transport system permease component
C4J97_RS01175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J97_RS01180	COG1464	Belongs to the NlpA lipoprotein family
C4J97_RS01210	COG1126	abc transporter atp-binding protein
C4J97_RS01215	COG0765	amino acid transport
C4J97_RS01220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS01230	COG1045	serine acetyltransferase
C4J97_RS01235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J97_RS01240	COG0667	Aldo Keto reductase
C4J97_RS01245	COG2175	clavaminate synthase activity
C4J97_RS01250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J97_RS01255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4J97_RS01260	COG4521	taurine ABC transporter
C4J97_RS01265	COG2918	glutathione biosynthetic process
C4J97_RS01275	COG2183	response to ionizing radiation
C4J97_RS01290	COG0189	ligase activity
C4J97_RS01295	COG4067	protein conserved in archaea
C4J97_RS01295	COG0189	ligase activity
C4J97_RS01300	COG2200	EAL domain
C4J97_RS01305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4J97_RS01315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4J97_RS01320	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4J97_RS01355	COG2184	nucleotidyltransferase activity
C4J97_RS01370	COG0514	ATP-dependent DNA helicase (RecQ)
C4J97_RS01375	COG0824	Thioesterase
C4J97_RS01385	COG0243	molybdopterin cofactor binding
C4J97_RS01390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4J97_RS01395	COG1652	LysM domain
C4J97_RS01400	COG1011	Hydrolase
C4J97_RS01405	COG0494	nUDIX hydrolase
C4J97_RS01410	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4J97_RS01450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J97_RS01455	COG2957	Belongs to the agmatine deiminase family
C4J97_RS01475	COG3321	synthase
C4J97_RS01475	COG0604	alcohol dehydrogenase
C4J97_RS01485	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS01490	COG1309	transcriptional regulator
C4J97_RS01495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J97_RS01570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4J97_RS01575	COG1194	a g-specific adenine glycosylase
C4J97_RS01585	COG2223	nitrite transmembrane transporter activity
C4J97_RS01590	COG0131	Imidazoleglycerol-phosphate dehydratase
C4J97_RS01595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4J97_RS01605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4J97_RS01610	COG0107	imidazoleglycerol-phosphate synthase activity
C4J97_RS01620	COG2861	carbohydrate metabolic process
C4J97_RS01625	COG0793	Belongs to the peptidase S41A family
C4J97_RS01630	COG4942	peptidase
C4J97_RS01635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4J97_RS01640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J97_RS01650	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4J97_RS01675	COG3852	Histidine kinase
C4J97_RS01705	COG0301	tRNA thio-modification
C4J97_RS01705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J97_RS01710	COG1217	gtp-binding protein TYPA
C4J97_RS01720	COG0058	SHG alpha-glucan phosphorylase activity
C4J97_RS01735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4J97_RS01750	COG0402	S-adenosylhomocysteine deaminase activity
C4J97_RS01755	COG2188	Transcriptional regulator
C4J97_RS01765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4J97_RS01770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J97_RS01780	COG4176	ABC-type proline glycine betaine transport system permease component
C4J97_RS01785	COG4175	Glycine betaine
C4J97_RS01785	COG0517	IMP dehydrogenase activity
C4J97_RS01790	COG2986	histidine ammonia-lyase
C4J97_RS01795	COG2986	histidine ammonia-lyase
C4J97_RS01800	COG1113	amino acid transport
C4J97_RS01805	COG1228	amidohydrolase
C4J97_RS01815	COG0596	Alpha beta hydrolase
C4J97_RS01820	COG1490	D-aminoacyl-tRNA deacylase activity
C4J97_RS01825	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J97_RS01830	COG2943	transferase activity, transferring hexosyl groups
C4J97_RS01845	COG0765	amino acid transport
C4J97_RS01850	COG1126	abc transporter atp-binding protein
C4J97_RS01855	COG0840	transmembrane signaling receptor activity
C4J97_RS01860	COG0840	transmembrane signaling receptor activity
C4J97_RS01875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J97_RS01880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J97_RS01885	COG0140	phosphoribosyl-ATP diphosphatase activity
C4J97_RS01890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J97_RS01895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J97_RS01905	COG2226	methyltransferase
C4J97_RS01935	COG3188	usher protein
C4J97_RS01940	COG3121	Chaperone
C4J97_RS01945	COG3121	Chaperone
C4J97_RS01955	COG2197	response regulator
C4J97_RS01985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4J97_RS01990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4J97_RS02000	COG0018	arginyl-trna synthetase
C4J97_RS02010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4J97_RS02015	COG0254	rRNA binding
C4J97_RS02025	COG0281	malic enzyme
C4J97_RS02055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4J97_RS02060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J97_RS02075	COG0070	glutamate synthase
C4J97_RS02075	COG0069	glutamate synthase activity
C4J97_RS02075	COG0067	glutamate synthase
C4J97_RS02080	COG0493	'glutamate synthase
C4J97_RS02085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4J97_RS02090	COG2814	Major facilitator Superfamily
C4J97_RS02095	COG0583	DNA-binding transcription factor activity
C4J97_RS02105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J97_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS02120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J97_RS02130	COG2226	methyltransferase
C4J97_RS02155	COG2986	histidine ammonia-lyase
C4J97_RS02170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J97_RS02180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J97_RS02185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J97_RS02200	COG1192	Involved in chromosome partitioning
C4J97_RS02220	COG3118	belongs to the thioredoxin family
C4J97_RS02235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4J97_RS02240	COG3264	Mechanosensitive ion channel
C4J97_RS02240	COG1196	nuclear chromosome segregation
C4J97_RS02245	COG3263	regulation of cellular component size
C4J97_RS02265	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS02275	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J97_RS02275	COG0506	proline dehydrogenase activity
C4J97_RS02275	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J97_RS02280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J97_RS02295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4J97_RS02310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J97_RS02330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J97_RS02335	COG0859	PFAM glycosyl transferase family 9
C4J97_RS02340	COG0859	PFAM glycosyl transferase family 9
C4J97_RS02345	COG0438	transferase activity, transferring glycosyl groups
C4J97_RS02370	COG4772	TonB-dependent receptor
C4J97_RS02380	COG2192	nodulation
C4J97_RS02395	COG0438	transferase activity, transferring glycosyl groups
C4J97_RS02400	COG1215	transferase activity, transferring glycosyl groups
C4J97_RS02410	COG1132	(ABC) transporter
C4J97_RS02420	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4J97_RS02420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4J97_RS02425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J97_RS02435	COG0667	Aldo Keto reductase
C4J97_RS02450	COG1519	Transferase
C4J97_RS02455	COG1538	Outer membrane efflux protein
C4J97_RS02460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4J97_RS02475	COG0494	nUDIX hydrolase
C4J97_RS02485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J97_RS02490	COG3150	esterase
C4J97_RS02520	COG0560	Phosphoserine phosphatase
C4J97_RS02520	COG3830	Belongs to the UPF0237 family
C4J97_RS02525	COG0688	phosphatidylethanolamine metabolic process
C4J97_RS02555	COG1162	GTPase activity
C4J97_RS02560	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4J97_RS02570	COG2860	membrane
C4J97_RS02580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4J97_RS02580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4J97_RS02585	COG0802	atpase or kinase
C4J97_RS02590	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J97_RS02595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4J97_RS02600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4J97_RS02605	COG1923	regulation of RNA biosynthetic process
C4J97_RS02610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4J97_RS02615	COG0330	HflC and HflK could
C4J97_RS02620	COG0330	HflC and HflK could
C4J97_RS02625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4J97_RS02630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4J97_RS02640	COG1178	ABC-type Fe3 transport system permease component
C4J97_RS02645	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J97_RS02660	COG0557	exoribonuclease II activity
C4J97_RS02665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J97_RS02670	COG0360	Binds together with S18 to 16S ribosomal RNA
C4J97_RS02675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J97_RS02685	COG0359	binds to the 23S rRNA
C4J97_RS02690	COG0305	Participates in initiation and elongation during chromosome replication
C4J97_RS02700	COG1032	radical SAM domain protein
C4J97_RS02740	COG2308	Evidence 4 Homologs of previously reported genes of
C4J97_RS02740	COG2307	Protein conserved in bacteria
C4J97_RS02760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J97_RS02765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4J97_RS02770	COG0583	DNA-binding transcription factor activity
C4J97_RS02775	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS02815	COG4221	oxidoreductase activity
C4J97_RS02835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4J97_RS02840	COG0830	nickel cation binding
C4J97_RS02845	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4J97_RS02850	COG0791	NLP P60 protein
C4J97_RS02855	COG1309	transcriptional regulator
C4J97_RS02865	COG2982	Protein involved in outer membrane biogenesis
C4J97_RS02875	COG0697	spore germination
C4J97_RS02900	COG0443	Heat shock 70 kDa protein
C4J97_RS02910	COG0484	heat shock protein binding
C4J97_RS02915	COG0804	urea catabolic process
C4J97_RS02920	COG0832	Belongs to the urease beta subunit family
C4J97_RS02935	COG0831	urea catabolic process
C4J97_RS02940	COG0829	nickel cation binding
C4J97_RS02950	COG0411	ABC transporter
C4J97_RS03015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J97_RS03040	COG2095	MarC family integral membrane protein
C4J97_RS03050	COG0151	Belongs to the GarS family
C4J97_RS03060	COG0138	bifunctional purine biosynthesis protein purh
C4J97_RS03070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J97_RS03080	COG2264	protein methyltransferase activity
C4J97_RS03095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J97_RS03120	COG0023	Translation Initiation Factor
C4J97_RS03125	COG1166	arginine decarboxylase activity
C4J97_RS03130	COG0534	Mate efflux family protein
C4J97_RS03135	COG2373	Large extracellular alpha-helical protein
C4J97_RS03145	COG4953	penicillin-binding protein 1C
C4J97_RS03155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J97_RS03240	COG4964	Belongs to the GSP D family
C4J97_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS03290	COG2217	Heavy metal translocating P-type atpase
C4J97_RS03305	COG2814	Major facilitator Superfamily
C4J97_RS03310	COG0604	alcohol dehydrogenase
C4J97_RS03315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4J97_RS03320	COG0583	DNA-binding transcription factor activity
C4J97_RS03330	COG0477	Major facilitator Superfamily
C4J97_RS03335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J97_RS03340	COG0387	Pfam Sodium calcium exchanger
C4J97_RS03360	COG1309	transcriptional regulator
C4J97_RS03365	COG2233	PERMEase
C4J97_RS03415	COG2995	paraquat-inducible protein a
C4J97_RS03420	COG2995	paraquat-inducible protein a
C4J97_RS03425	COG3008	intermembrane lipid transfer
C4J97_RS03450	COG0456	acetyltransferase
C4J97_RS03460	COG0288	reversible hydration of carbon dioxide
C4J97_RS03475	COG2031	fatty acid transporter
C4J97_RS03480	COG0477	Major facilitator Superfamily
C4J97_RS03505	COG0405	Gamma-glutamyltransferase
C4J97_RS03545	COG1157	protein secretion by the type III secretion system
C4J97_RS03560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J97_RS03570	COG4794	Type iii secretion
C4J97_RS03580	COG4792	protein secretion
C4J97_RS03620	COG4669	(LipO)protein
C4J97_RS03640	COG0193	aminoacyl-tRNA hydrolase activity
C4J97_RS03645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4J97_RS03650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J97_RS03660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4J97_RS03665	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4J97_RS03680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4J97_RS03685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4J97_RS03695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4J97_RS03700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4J97_RS03720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J97_RS03735	COG4221	oxidoreductase activity
C4J97_RS03745	COG0415	Belongs to the DNA photolyase family
C4J97_RS03750	COG0789	Transcriptional regulator
C4J97_RS03765	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4J97_RS03770	COG1090	epimerase
C4J97_RS03775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4J97_RS03790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J97_RS03800	COG0175	sulfate reduction
C4J97_RS03810	COG0204	Acyl-transferase
C4J97_RS03815	COG0280	phosphate acetyltransferase
C4J97_RS03815	COG0857	belongs to the CobB CobQ family
C4J97_RS03830	COG0268	Binds directly to 16S ribosomal RNA
C4J97_RS03835	COG0728	peptidoglycan biosynthetic process
C4J97_RS03840	COG0196	riboflavin kinase activity
C4J97_RS03845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4J97_RS03850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J97_RS03855	COG1047	Peptidyl-prolyl cis-trans
C4J97_RS03860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4J97_RS03890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS03915	COG0542	response to heat
C4J97_RS03940	COG1252	NADH dehydrogenase
C4J97_RS03965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4J97_RS03970	COG0237	dephospho-CoA kinase activity
C4J97_RS04010	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J97_RS04025	COG0084	hydrolase, TatD family'
C4J97_RS04030	COG1609	Transcriptional regulator
C4J97_RS04040	COG1105	Belongs to the carbohydrate kinase PfkB family
C4J97_RS04045	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4J97_RS04045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J97_RS04045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J97_RS04055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4J97_RS04060	COG4774	siderophore transport
C4J97_RS04065	COG3128	pkhd-type hydroxylase
C4J97_RS04075	COG0019	diaminopimelate decarboxylase activity
C4J97_RS04100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4J97_RS04110	COG4608	Belongs to the ABC transporter superfamily
C4J97_RS04115	COG0444	Belongs to the ABC transporter superfamily
C4J97_RS04120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J97_RS04125	COG0601	transmembrane transport
C4J97_RS04130	COG0747	negative chemotaxis
C4J97_RS04140	COG0747	negative chemotaxis
C4J97_RS04145	COG0747	negative chemotaxis
C4J97_RS04150	COG0747	negative chemotaxis
C4J97_RS04165	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4J97_RS04185	COG0180	Tryptophanyl-tRNA synthetase
C4J97_RS04190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J97_RS04200	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS04205	COG0667	Aldo Keto reductase
C4J97_RS04210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4J97_RS04215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4J97_RS04220	COG0723	plastoquinol--plastocyanin reductase activity
C4J97_RS04225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J97_RS04230	COG2857	Cytochrome c1
C4J97_RS04235	COG0625	glutathione transferase activity
C4J97_RS04240	COG2969	positive regulation of protein catabolic process
C4J97_RS04245	COG2186	Transcriptional regulator
C4J97_RS04255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J97_RS04265	COG2271	Major facilitator Superfamily
C4J97_RS04270	COG2721	sulfolactate sulfo-lyase activity
C4J97_RS04300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J97_RS04305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J97_RS04310	COG0154	amidase activity
C4J97_RS04315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J97_RS04320	COG1077	Cell shape determining protein MreB Mrl
C4J97_RS04325	COG1792	Involved in formation and maintenance of cell shape
C4J97_RS04335	COG0424	maF-like protein
C4J97_RS04340	COG1530	ribonuclease E activity
C4J97_RS04350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J97_RS04355	COG0312	modulator of DNA gyrase
C4J97_RS04360	COG3028	Belongs to the UPF0307 family
C4J97_RS04365	COG0312	modulator of DNA gyrase
C4J97_RS04395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J97_RS04400	COG1660	Displays ATPase and GTPase activities
C4J97_RS04410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4J97_RS04415	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4J97_RS04420	COG1137	ATPase activity
C4J97_RS04425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4J97_RS04435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4J97_RS04445	COG1127	ABC transporter
C4J97_RS04450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J97_RS04455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4J97_RS04475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J97_RS04480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4J97_RS04485	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4J97_RS04490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J97_RS04500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4J97_RS04505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4J97_RS04560	COG2135	peptidase activity
C4J97_RS04565	COG0501	Belongs to the peptidase M48B family
C4J97_RS04570	COG2119	membrane
C4J97_RS04575	COG2813	Specifically methylates the guanine in position
C4J97_RS04580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J97_RS04585	COG1280	lysine exporter protein (LysE YggA)
C4J97_RS04590	COG0318	PFAM AMP-dependent synthetase and ligase
C4J97_RS04615	COG3008	intermembrane lipid transfer
C4J97_RS04620	COG2995	paraquat-inducible protein a
C4J97_RS04630	COG2885	chlorophyll binding
C4J97_RS04635	COG2823	Periplasmic or secreted lipoprotein
C4J97_RS04640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4J97_RS04645	COG0792	nuclease activity
C4J97_RS04665	COG2001	Belongs to the MraZ family
C4J97_RS04670	COG0275	rRNA processing
C4J97_RS04685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J97_RS04690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4J97_RS04695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J97_RS04700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J97_RS04705	COG0772	Belongs to the SEDS family
C4J97_RS04710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J97_RS04715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J97_RS04720	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J97_RS04735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4J97_RS04740	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4J97_RS04745	COG2203	Gaf domain
C4J97_RS04745	COG3706	GGDEF domain
C4J97_RS04745	COG4251	negative regulation of phosphorylation
C4J97_RS04745	COG5001	Diguanylate cyclase
C4J97_RS04755	COG5002	protein histidine kinase activity
C4J97_RS04780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS04795	COG0784	Response regulator, receiver
C4J97_RS04795	COG0835	chemotaxis
C4J97_RS04805	COG0583	DNA-binding transcription factor activity
C4J97_RS04830	COG1566	PFAM secretion protein HlyD family protein
C4J97_RS04840	COG0300	oxidoreductase activity
C4J97_RS04850	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J97_RS04850	COG0662	Cupin 2, conserved barrel domain protein
C4J97_RS04870	COG1696	Membrane protein involved in D-alanine export
C4J97_RS04885	COG3420	alginic acid biosynthetic process
C4J97_RS04895	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4J97_RS04900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS04910	COG1215	transferase activity, transferring glycosyl groups
C4J97_RS04920	COG3022	response to hydroperoxide
C4J97_RS04970	COG0167	dihydroorotate dehydrogenase activity
C4J97_RS04995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4J97_RS05000	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J97_RS05005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4J97_RS05025	COG0513	Belongs to the DEAD box helicase family
C4J97_RS05035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS05040	COG4597	amino acid ABC transporter
C4J97_RS05045	COG0765	amino acid transport
C4J97_RS05050	COG1126	abc transporter atp-binding protein
C4J97_RS05065	COG2807	transmembrane transport
C4J97_RS05075	COG3539	Fimbrial protein
C4J97_RS05080	COG3188	usher protein
C4J97_RS05085	COG3121	Chaperone
C4J97_RS05100	COG3539	Fimbrial protein
C4J97_RS05105	COG3539	Fimbrial protein
C4J97_RS05110	COG2205	protein histidine kinase activity
C4J97_RS05110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS05130	COG2827	Endonuclease containing a URI domain
C4J97_RS05135	COG4774	siderophore transport
C4J97_RS05140	COG2027	D-alanyl-D-alanine carboxypeptidase
C4J97_RS05150	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4J97_RS05155	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J97_RS05210	COG1760	l-serine dehydratase
C4J97_RS05215	COG0583	DNA-binding transcription factor activity
C4J97_RS05225	COG0477	Major facilitator Superfamily
C4J97_RS05230	COG0583	DNA-binding transcription factor activity
C4J97_RS05235	COG4772	TonB-dependent receptor
C4J97_RS05240	COG3712	iron ion homeostasis
C4J97_RS05245	COG1595	DNA-templated transcription, initiation
C4J97_RS05280	COG3081	Nucleoid-associated protein
C4J97_RS05290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4J97_RS05295	COG0525	valine-tRNA ligase activity
C4J97_RS05310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4J97_RS05315	COG0795	lipopolysaccharide-transporting ATPase activity
C4J97_RS05320	COG0795	lipopolysaccharide-transporting ATPase activity
C4J97_RS05325	COG0481	GTPase activity
C4J97_RS05330	COG0681	Belongs to the peptidase S26 family
C4J97_RS05335	COG0571	ribonuclease III activity
C4J97_RS05340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4J97_RS05345	COG1381	Involved in DNA repair and RecF pathway recombination
C4J97_RS05350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4J97_RS05360	COG0590	tRNA wobble adenosine to inosine editing
C4J97_RS05365	COG0500	methyltransferase
C4J97_RS05370	COG2226	methyltransferase
C4J97_RS05380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J97_RS05400	COG2346	COG2346, Truncated hemoglobins
C4J97_RS05410	COG4206	TonB-dependent receptor
C4J97_RS05415	COG4628	conserved protein (DUF2132)
C4J97_RS05425	COG2375	cellular response to nickel ion
C4J97_RS05430	COG1695	Transcriptional regulator
C4J97_RS05470	COG4886	Leucine-rich repeat (LRR) protein
C4J97_RS05480	COG1113	amino acid transport
C4J97_RS05495	COG0069	glutamate synthase activity
C4J97_RS05505	COG0254	rRNA binding
C4J97_RS05530	COG1858	cytochrome C peroxidase
C4J97_RS05545	COG0494	nUDIX hydrolase
C4J97_RS05550	COG0456	acetyltransferase
C4J97_RS05555	COG0583	DNA-binding transcription factor activity
C4J97_RS05580	COG2076	Multidrug Resistance protein
C4J97_RS05595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J97_RS05610	COG4191	Histidine kinase
C4J97_RS05615	COG2204	response regulator
C4J97_RS05635	COG1126	abc transporter atp-binding protein
C4J97_RS05640	COG0765	amino acid transport
C4J97_RS05645	COG0765	amino acid transport
C4J97_RS05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS05665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J97_RS05675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4J97_RS05680	COG3842	ATPase activity
C4J97_RS05685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4J97_RS05695	COG0243	molybdopterin cofactor binding
C4J97_RS05700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4J97_RS05715	COG0450	alkyl hydroperoxide reductase
C4J97_RS05720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J97_RS05725	COG0418	dihydroorotase activity
C4J97_RS05735	COG0137	argininosuccinate synthase activity
C4J97_RS05740	COG2197	response regulator
C4J97_RS05750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4J97_RS05755	COG2878	Part of a membrane complex involved in electron transport
C4J97_RS05760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J97_RS05760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J97_RS05765	COG0489	protein tyrosine kinase activity
C4J97_RS05770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4J97_RS05775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4J97_RS05875	COG3179	chitinase
C4J97_RS05885	COG1546	Belongs to the CinA family
C4J97_RS05890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4J97_RS05895	COG2137	regulation of response to DNA damage stimulus
C4J97_RS05910	COG3148	PFAM DTW domain containing protein
C4J97_RS05925	COG0583	DNA-binding transcription factor activity
C4J97_RS05940	COG4807	Protein conserved in bacteria
C4J97_RS05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J97_RS05965	COG3657	addiction module killer protein
C4J97_RS05970	COG3158	transport of potassium into the cell
C4J97_RS05975	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS05985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J97_RS06005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J97_RS06005	COG0457	Tetratricopeptide repeat
C4J97_RS06020	COG2201	protein-glutamate methylesterase activity
C4J97_RS06025	COG5001	Diguanylate cyclase
C4J97_RS06025	COG4251	negative regulation of phosphorylation
C4J97_RS06025	COG3706	GGDEF domain
C4J97_RS06025	COG2203	Gaf domain
C4J97_RS06035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4J97_RS06050	COG1073	alpha beta
C4J97_RS06070	COG2885	chlorophyll binding
C4J97_RS06085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4J97_RS06090	COG0563	adenylate kinase activity
C4J97_RS06095	COG1214	PFAM Peptidase M22, glycoprotease
C4J97_RS06105	COG1801	Protein of unknown function DUF72
C4J97_RS06125	COG0742	ribosomal rna small subunit methyltransferase
C4J97_RS06140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS06170	COG2937	Belongs to the GPAT DAPAT family
C4J97_RS06185	COG2226	methyltransferase
C4J97_RS06190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J97_RS06195	COG1215	transferase activity, transferring glycosyl groups
C4J97_RS06200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4J97_RS06205	COG2166	iron-sulfur cluster assembly
C4J97_RS06210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J97_RS06215	COG2171	N-acyltransferase activity
C4J97_RS06220	COG1393	Belongs to the ArsC family
C4J97_RS06225	COG0025	NhaP-type Na H and K H
C4J97_RS06235	COG0436	Aminotransferase
C4J97_RS06240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4J97_RS06245	COG0024	Methionine aminopeptidase
C4J97_RS06250	COG0052	Belongs to the universal ribosomal protein uS2 family
C4J97_RS06255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4J97_RS06260	COG0528	UMP kinase activity
C4J97_RS06265	COG0233	cytoplasmic translational termination
C4J97_RS06270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J97_RS06280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4J97_RS06300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J97_RS06305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J97_RS06310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J97_RS06315	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J97_RS06320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4J97_RS06325	COG0587	DNA-directed DNA polymerase activity
C4J97_RS06330	COG0825	malonyl-CoA metabolic process
C4J97_RS06335	COG0037	tRNA processing
C4J97_RS06340	COG0504	CTP synthase activity
C4J97_RS06345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4J97_RS06350	COG0148	phosphopyruvate hydratase activity
C4J97_RS06360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4J97_RS06375	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4J97_RS06380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4J97_RS06385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4J97_RS06390	COG0585	pseudouridine synthase activity
C4J97_RS06395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4J97_RS06400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4J97_RS06415	COG1278	Cold shock
C4J97_RS06420	COG0717	Belongs to the dCTP deaminase family
C4J97_RS06435	COG1201	RNA secondary structure unwinding
C4J97_RS06450	COG4160	amino acid transport
C4J97_RS06465	COG1793	dna ligase
C4J97_RS06475	COG2366	antibiotic biosynthetic process
C4J97_RS06480	COG0653	protein targeting
C4J97_RS06490	COG3012	SEC-C Motif Domain Protein
C4J97_RS06510	COG1199	ATP-dependent helicase activity
C4J97_RS06520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J97_RS06530	COG0259	pyridoxamine-phosphate oxidase activity
C4J97_RS06540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J97_RS06550	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4J97_RS06580	COG3220	belongs to the UPF0276 family
C4J97_RS06625	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4J97_RS06630	COG2271	Major facilitator Superfamily
C4J97_RS06635	COG3415	Transposase
C4J97_RS06635	COG2801	Transposase and inactivated derivatives
C4J97_RS06645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J97_RS06655	COG0306	phosphate transporter
C4J97_RS06665	COG1414	Transcriptional regulator
C4J97_RS06670	COG2814	Major facilitator Superfamily
C4J97_RS06680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J97_RS06685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4J97_RS06690	COG0183	Belongs to the thiolase family
C4J97_RS06695	COG3485	protocatechuate 3,4-dioxygenase
C4J97_RS06700	COG3485	protocatechuate 3,4-dioxygenase
C4J97_RS06705	COG0477	Major facilitator Superfamily
C4J97_RS06715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J97_RS06720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J97_RS06745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS06750	COG1309	transcriptional regulator
C4J97_RS06755	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS06795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J97_RS06805	COG1704	LemA family
C4J97_RS06825	COG1629	transport
C4J97_RS06850	COG1454	alcohol dehydrogenase
C4J97_RS06875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J97_RS06890	COG2267	carboxylic ester hydrolase activity
C4J97_RS06925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J97_RS06990	COG0354	folic acid binding
C4J97_RS06995	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4J97_RS07030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J97_RS07040	COG0425	Belongs to the sulfur carrier protein TusA family
C4J97_RS07045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4J97_RS07055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J97_RS07060	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4J97_RS07065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J97_RS07070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4J97_RS07080	COG2026	Addiction module toxin, RelE StbE family
C4J97_RS07085	COG3077	Addiction module antitoxin, RelB DinJ family
C4J97_RS07105	COG4680	protein conserved in bacteria
C4J97_RS07115	COG4191	Histidine kinase
C4J97_RS07115	COG0784	Response regulator, receiver
C4J97_RS07130	COG2172	sigma factor antagonist activity
C4J97_RS07135	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J97_RS07140	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J97_RS07155	COG0583	DNA-binding transcription factor activity
C4J97_RS07185	COG2807	transmembrane transport
C4J97_RS07190	COG2910	NAD(P)H-binding
C4J97_RS07200	COG0583	DNA-binding transcription factor activity
C4J97_RS07250	COG3100	YcgL domain-containing protein
C4J97_RS07255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J97_RS07265	COG2983	Belongs to the UPF0260 family
C4J97_RS07305	COG1770	oligopeptidase
C4J97_RS07315	COG0121	glutamine amidotransferase
C4J97_RS07330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4J97_RS07335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4J97_RS07340	COG1984	allophanate hydrolase subunit 2
C4J97_RS07350	COG0542	response to heat
C4J97_RS07360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J97_RS07380	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4J97_RS07385	COG0425	Belongs to the sulfur carrier protein TusA family
C4J97_RS07395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J97_RS07400	COG1132	(ABC) transporter
C4J97_RS07410	COG0741	lytic transglycosylase activity
C4J97_RS07415	COG0488	(ABC) transporter
C4J97_RS07420	COG0589	response to stress
C4J97_RS07430	COG1024	Enoyl-CoA hydratase
C4J97_RS07430	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J97_RS07435	COG0183	Belongs to the thiolase family
C4J97_RS07480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J97_RS07490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4J97_RS07505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J97_RS07510	COG0584	glycerophosphoryl diester phosphodiesterase
C4J97_RS07520	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J97_RS07525	COG1136	(ABC) transporter
C4J97_RS07530	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J97_RS07550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J97_RS07550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J97_RS07565	COG2853	Lipoprotein
C4J97_RS07580	COG2204	response regulator
C4J97_RS07590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J97_RS07595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J97_RS07630	COG2814	Major facilitator Superfamily
C4J97_RS07635	COG0579	oxidoreductase
C4J97_RS07640	COG0583	DNA-binding transcription factor activity
C4J97_RS07645	COG0697	spore germination
C4J97_RS07665	COG1611	Belongs to the LOG family
C4J97_RS07675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4J97_RS07690	COG0583	DNA-binding transcription factor activity
C4J97_RS07695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J97_RS07700	COG0583	DNA-binding transcription factor activity
C4J97_RS07705	COG2814	Major facilitator Superfamily
C4J97_RS07710	COG2233	PERMEase
C4J97_RS07720	COG2267	carboxylic ester hydrolase activity
C4J97_RS07725	COG2197	response regulator
C4J97_RS07730	COG0596	Alpha beta hydrolase
C4J97_RS07740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J97_RS07745	COG0444	Belongs to the ABC transporter superfamily
C4J97_RS07755	COG0747	negative chemotaxis
C4J97_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS07765	COG0546	phosphoglycolate phosphatase activity
C4J97_RS07770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J97_RS07775	COG0402	S-adenosylhomocysteine deaminase activity
C4J97_RS07780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4J97_RS07790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4J97_RS07800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J97_RS07805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J97_RS07810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4J97_RS07825	COG0463	Glycosyl transferase, family 2
C4J97_RS07840	COG0776	regulation of translation
C4J97_RS07860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J97_RS07865	COG2244	polysaccharide biosynthetic process
C4J97_RS07890	COG1086	Polysaccharide biosynthesis protein
C4J97_RS07905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J97_RS07915	COG1555	photosystem II stabilization
C4J97_RS07940	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J97_RS07950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J97_RS07955	COG2205	protein histidine kinase activity
C4J97_RS07960	COG0745	RESPONSE REGULATOR receiver
C4J97_RS07995	COG0084	hydrolase, TatD family'
C4J97_RS08000	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J97_RS08025	COG1131	(ABC) transporter
C4J97_RS08035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J97_RS08040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4J97_RS08045	COG4181	ATPase activity
C4J97_RS08060	COG1376	ErfK ybiS ycfS ynhG family protein
C4J97_RS08090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4J97_RS08110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J97_RS08125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4J97_RS08135	COG1764	response to oxidative stress
C4J97_RS08140	COG1846	Transcriptional regulator
C4J97_RS08145	COG0583	DNA-binding transcription factor activity
C4J97_RS08150	COG0730	response to heat
C4J97_RS08155	COG0583	DNA-binding transcription factor activity
C4J97_RS08165	COG3214	Protein conserved in bacteria
C4J97_RS08170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J97_RS08190	COG3384	dioxygenase
C4J97_RS08195	COG0500	methyltransferase
C4J97_RS08200	COG0501	Belongs to the peptidase M48B family
C4J97_RS08205	COG0436	Aminotransferase
C4J97_RS08210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J97_RS08220	COG0386	Belongs to the glutathione peroxidase family
C4J97_RS08225	COG5002	protein histidine kinase activity
C4J97_RS08225	COG0784	Response regulator, receiver
C4J97_RS08225	COG2205	protein histidine kinase activity
C4J97_RS08235	COG1956	GAF domain-containing protein
C4J97_RS08240	COG2205	protein histidine kinase activity
C4J97_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS08245	COG2197	response regulator
C4J97_RS08280	COG0004	ammonium transporteR
C4J97_RS08305	COG0746	molybdenum cofactor guanylyltransferase activity
C4J97_RS08310	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4J97_RS08315	COG0303	'Molybdopterin
C4J97_RS08320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J97_RS08330	COG4133	protoheme IX ABC transporter activity
C4J97_RS08350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4J97_RS08355	COG1138	Cytochrome C-type biogenesis protein
C4J97_RS08365	COG3088	subunit of a heme lyase
C4J97_RS08370	COG4235	cytochrome complex assembly
C4J97_RS08390	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4J97_RS08405	COG2814	Major facilitator Superfamily
C4J97_RS08415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J97_RS08435	COG2084	Dehydrogenase
C4J97_RS08440	COG3622	Belongs to the hyi family
C4J97_RS08445	COG3960	tartronate-semialdehyde synthase activity
C4J97_RS08455	COG1309	transcriptional regulator
C4J97_RS08460	COG2354	Protein conserved in bacteria
C4J97_RS08465	COG2853	Lipoprotein
C4J97_RS08490	COG2113	Glycine betaine
C4J97_RS08495	COG3162	membrane
C4J97_RS08500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J97_RS08510	COG2009	succinate dehydrogenase
C4J97_RS08515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4J97_RS08520	COG1053	succinate dehydrogenase
C4J97_RS08525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J97_RS08540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J97_RS08545	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J97_RS08580	COG0326	Molecular chaperone. Has ATPase activity
C4J97_RS08590	COG1741	Belongs to the pirin family
C4J97_RS08615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J97_RS08620	COG2205	protein histidine kinase activity
C4J97_RS08620	COG0784	Response regulator, receiver
C4J97_RS08620	COG5002	protein histidine kinase activity
C4J97_RS08635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J97_RS08670	COG0628	permease
C4J97_RS08685	COG0284	orotidine-5'-phosphate decarboxylase activity
C4J97_RS08690	COG2130	NADP-dependent
C4J97_RS08705	COG0840	transmembrane signaling receptor activity
C4J97_RS08745	COG0633	Ferredoxin
C4J97_RS08745	COG3217	Mosc domain protein beta barrel domain protein
C4J97_RS08760	COG0811	peptide transport
C4J97_RS08780	COG3540	Alkaline phosphatase
C4J97_RS08785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J97_RS08800	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS08810	COG0625	glutathione transferase activity
C4J97_RS08815	COG1131	(ABC) transporter
C4J97_RS08820	COG0842	Transport permease protein
C4J97_RS08840	COG0477	Major facilitator Superfamily
C4J97_RS08845	COG2076	Multidrug Resistance protein
C4J97_RS08850	COG0385	Bile acid
C4J97_RS08855	COG2974	May be involved in recombination
C4J97_RS08905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS08910	COG0747	negative chemotaxis
C4J97_RS08915	COG0601	transmembrane transport
C4J97_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J97_RS08940	COG0473	3-isopropylmalate dehydrogenase activity
C4J97_RS08945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J97_RS08950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J97_RS08960	COG1522	sequence-specific DNA binding
C4J97_RS08970	COG2010	Cytochrome c
C4J97_RS08975	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J97_RS09000	COG2200	EAL domain
C4J97_RS09015	COG3842	ATPase activity
C4J97_RS09025	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J97_RS09050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J97_RS09055	COG1121	(ABC) transporter
C4J97_RS09085	COG1509	lysine 2,3-aminomutase activity
C4J97_RS09090	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J97_RS09115	COG3829	transcription factor binding
C4J97_RS09140	COG5006	permease, DMT superfamily
C4J97_RS09170	COG0768	penicillin binding
C4J97_RS09180	COG0417	DNA replication proofreading
C4J97_RS09200	COG0728	peptidoglycan biosynthetic process
C4J97_RS09245	COG0662	Cupin 2, conserved barrel domain protein
C4J97_RS09245	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J97_RS09250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4J97_RS09265	COG1595	DNA-templated transcription, initiation
C4J97_RS09275	COG4977	sequence-specific DNA binding
C4J97_RS09280	COG0596	Alpha beta hydrolase
C4J97_RS09285	COG3387	PFAM Glycoside hydrolase 15-related
C4J97_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS09310	COG2223	nitrite transmembrane transporter activity
C4J97_RS09330	COG3675	Pfam Lipase (class 3)
C4J97_RS09335	COG0402	S-adenosylhomocysteine deaminase activity
C4J97_RS09340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J97_RS09345	COG0720	synthase
C4J97_RS09385	COG0840	transmembrane signaling receptor activity
C4J97_RS09390	COG2056	Na+-H+ antiporter family
C4J97_RS09400	COG0826	peptidase U32
C4J97_RS09405	COG0628	permease
C4J97_RS09425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J97_RS09430	COG3132	Protein of unknown function, DUF480
C4J97_RS09440	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4J97_RS09445	COG0583	DNA-binding transcription factor activity
C4J97_RS09455	COG1253	flavin adenine dinucleotide binding
C4J97_RS09465	COG0709	Synthesizes selenophosphate from selenide and ATP
C4J97_RS09470	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4J97_RS09480	COG0701	Predicted permease
C4J97_RS09490	COG0625	glutathione transferase activity
C4J97_RS09495	COG0384	phenazine biosynthesis protein PhzF
C4J97_RS09500	COG0113	porphobilinogen synthase activity
C4J97_RS09510	COG3209	COG3209 Rhs family protein
C4J97_RS09530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J97_RS09535	COG0583	DNA-binding transcription factor activity
C4J97_RS09545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4J97_RS09550	COG0517	IMP dehydrogenase activity
C4J97_RS09555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J97_RS09560	COG0477	Major facilitator Superfamily
C4J97_RS09575	COG0174	glutamine synthetase
C4J97_RS09625	COG0640	Transcriptional regulator
C4J97_RS09630	COG2124	cytochrome p450
C4J97_RS09640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J97_RS09650	COG2197	response regulator
C4J97_RS09655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS09655	COG2205	protein histidine kinase activity
C4J97_RS09665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4J97_RS09685	COG2197	response regulator
C4J97_RS09690	COG0322	excinuclease ABC activity
C4J97_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS09875	COG1942	4-Oxalocrotonate Tautomerase
C4J97_RS09880	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS09885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J97_RS09910	COG1070	Carbohydrate kinase
C4J97_RS09930	COG0300	oxidoreductase activity
C4J97_RS10000	COG0745	RESPONSE REGULATOR receiver
C4J97_RS10010	COG0643	Histidine kinase
C4J97_RS10010	COG2198	Histidine kinase
C4J97_RS10020	COG0835	chemotaxis
C4J97_RS10030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4J97_RS10035	COG2201	protein-glutamate methylesterase activity
C4J97_RS10055	COG0745	RESPONSE REGULATOR receiver
C4J97_RS10060	COG2205	protein histidine kinase activity
C4J97_RS10065	COG0583	DNA-binding transcription factor activity
C4J97_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS10080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4J97_RS10090	COG0581	inorganic phosphate transmembrane transporter activity
C4J97_RS10095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J97_RS10115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4J97_RS10135	COG1132	(ABC) transporter
C4J97_RS10155	COG3546	catalase activity
C4J97_RS10160	COG3685	Protein conserved in bacteria
C4J97_RS10165	COG0784	Response regulator, receiver
C4J97_RS10165	COG4191	Histidine kinase
C4J97_RS10175	COG0109	protoheme IX farnesyltransferase activity
C4J97_RS10185	COG1845	cytochrome c oxidase, subunit III
C4J97_RS10195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J97_RS10205	COG0531	amino acid
C4J97_RS10210	COG2801	Transposase and inactivated derivatives
C4J97_RS10210	COG3415	Transposase
C4J97_RS10255	COG3729	General stress protein
C4J97_RS10260	COG5001	Diguanylate cyclase
C4J97_RS10260	COG4251	negative regulation of phosphorylation
C4J97_RS10260	COG3706	GGDEF domain
C4J97_RS10260	COG2203	Gaf domain
C4J97_RS10290	COG2323	membrane
C4J97_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS10330	COG1058	Belongs to the CinA family
C4J97_RS10330	COG1546	Belongs to the CinA family
C4J97_RS10360	COG0583	DNA-binding transcription factor activity
C4J97_RS10370	COG4948	Mandelate Racemase Muconate Lactonizing
C4J97_RS10420	COG4214	carbohydrate transport
C4J97_RS10425	COG1129	ABC transporter
C4J97_RS10430	COG4213	ABC transporter substrate-binding protein
C4J97_RS10435	COG2115	Belongs to the xylose isomerase family
C4J97_RS10450	COG2207	Transcriptional regulator
C4J97_RS10450	COG1609	Transcriptional regulator
C4J97_RS10465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J97_RS10475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J97_RS10555	COG3842	ATPase activity
C4J97_RS10565	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J97_RS10570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4J97_RS10575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J97_RS10600	COG2186	Transcriptional regulator
C4J97_RS10605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J97_RS10615	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS10620	COG2267	carboxylic ester hydrolase activity
C4J97_RS10635	COG3781	membrane
C4J97_RS10645	COG3706	GGDEF domain
C4J97_RS10650	COG0640	Transcriptional regulator
C4J97_RS10655	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS10665	COG1609	Transcriptional regulator
C4J97_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS10700	COG1879	ABC-type sugar transport system periplasmic component
C4J97_RS10705	COG1129	ABC transporter
C4J97_RS10710	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J97_RS10725	COG2207	Transcriptional regulator
C4J97_RS10735	COG0625	glutathione transferase activity
C4J97_RS10755	COG0673	inositol 2-dehydrogenase activity
C4J97_RS10790	COG1968	undecaprenyl-diphosphatase activity
C4J97_RS10805	COG1309	transcriptional regulator
C4J97_RS10815	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS10830	COG3321	synthase
C4J97_RS10830	COG0604	alcohol dehydrogenase
C4J97_RS10855	COG1064	alcohol dehydrogenase
C4J97_RS10860	COG4566	intracellular signal transduction
C4J97_RS10900	COG0475	glutathione-regulated potassium exporter activity
C4J97_RS10900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J97_RS10980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J97_RS10995	COG0534	Mate efflux family protein
C4J97_RS11065	COG1741	Belongs to the pirin family
C4J97_RS11100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4J97_RS11105	COG1335	isochorismatase
C4J97_RS11110	COG0583	DNA-binding transcription factor activity
C4J97_RS11120	COG5001	Diguanylate cyclase
C4J97_RS11120	COG5002	protein histidine kinase activity
C4J97_RS11120	COG3447	MASE1 domain protein
C4J97_RS11155	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS11160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J97_RS11165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS11180	COG0583	DNA-binding transcription factor activity
C4J97_RS11190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J97_RS11205	COG3284	Transcriptional regulator
C4J97_RS11210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J97_RS11215	COG0022	dehydrogenase e1 component
C4J97_RS11225	COG0583	DNA-binding transcription factor activity
C4J97_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS11245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4J97_RS11250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J97_RS11260	COG0596	Alpha beta hydrolase
C4J97_RS11265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4J97_RS11270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J97_RS11275	COG0583	DNA-binding transcription factor activity
C4J97_RS11310	COG0714	Associated with various cellular activities
C4J97_RS11345	COG2818	Glycosylase
C4J97_RS11355	COG0625	glutathione transferase activity
C4J97_RS11395	COG5002	protein histidine kinase activity
C4J97_RS11400	COG0745	RESPONSE REGULATOR receiver
C4J97_RS11420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J97_RS11430	COG3718	enzyme involved in inositol metabolism
C4J97_RS11440	COG3962	Belongs to the TPP enzyme family
C4J97_RS11445	COG0673	inositol 2-dehydrogenase activity
C4J97_RS11450	COG0673	inositol 2-dehydrogenase activity
C4J97_RS11460	COG1129	ABC transporter
C4J97_RS11465	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J97_RS11475	COG0840	transmembrane signaling receptor activity
C4J97_RS11540	COG0673	inositol 2-dehydrogenase activity
C4J97_RS11560	COG4172	Belongs to the ABC transporter superfamily
C4J97_RS11565	COG4239	(ABC) transporter, permease
C4J97_RS11570	COG4174	ABC transporter (Permease)
C4J97_RS11575	COG4166	transmembrane transport
C4J97_RS11580	COG4166	transmembrane transport
C4J97_RS11585	COG1388	LysM domain
C4J97_RS11585	COG0741	lytic transglycosylase activity
C4J97_RS11590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J97_RS11600	COG0328	RNA-DNA hybrid ribonuclease activity
C4J97_RS11605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J97_RS11615	COG0456	acetyltransferase
C4J97_RS11635	COG0431	NADPH-dependent FMN reductase
C4J97_RS11640	COG0028	Belongs to the TPP enzyme family
C4J97_RS11680	COG0789	Transcriptional regulator
C4J97_RS11735	COG0316	Belongs to the HesB IscA family
C4J97_RS11735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4J97_RS11790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4J97_RS11795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J97_RS11805	COG3139	Protein of unknown function (DUF1315)
C4J97_RS11815	COG0308	aminopeptidase N
C4J97_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS11850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J97_RS11865	COG0814	amino acid
C4J97_RS11880	COG0589	response to stress
C4J97_RS11895	COG0745	RESPONSE REGULATOR receiver
C4J97_RS11900	COG2205	protein histidine kinase activity
C4J97_RS11920	COG0697	spore germination
C4J97_RS11925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J97_RS11945	COG0154	amidase activity
C4J97_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS11975	COG0673	inositol 2-dehydrogenase activity
C4J97_RS11980	COG2223	nitrite transmembrane transporter activity
C4J97_RS11985	COG2207	Transcriptional regulator
C4J97_RS11995	COG2207	Transcriptional regulator
C4J97_RS12015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J97_RS12020	COG0348	domain, Protein
C4J97_RS12030	COG1285	pathogenesis
C4J97_RS12040	COG0366	Alpha amylase catalytic
C4J97_RS12045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J97_RS12065	COG4191	Histidine kinase
C4J97_RS12065	COG0784	Response regulator, receiver
C4J97_RS12085	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J97_RS12095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J97_RS12100	COG3012	SEC-C Motif Domain Protein
C4J97_RS12100	COG3318	Belongs to the UPF0149 family
C4J97_RS12105	COG1024	Enoyl-CoA hydratase
C4J97_RS12110	COG2816	NAD+ diphosphatase activity
C4J97_RS12135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J97_RS12140	COG1595	DNA-templated transcription, initiation
C4J97_RS12145	COG3712	iron ion homeostasis
C4J97_RS12160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4J97_RS12170	COG0708	Exodeoxyribonuclease III
C4J97_RS12185	COG0840	transmembrane signaling receptor activity
C4J97_RS12190	COG1968	undecaprenyl-diphosphatase activity
C4J97_RS12205	COG0583	DNA-binding transcription factor activity
C4J97_RS12210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J97_RS12230	COG0488	(ABC) transporter
C4J97_RS12255	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4J97_RS12265	COG2133	pyrroloquinoline quinone binding
C4J97_RS12295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J97_RS12300	COG2822	iron ion transport
C4J97_RS12310	COG2822	iron ion transport
C4J97_RS12315	COG0672	)-iron permease
C4J97_RS12320	COG2207	Transcriptional regulator
C4J97_RS12340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS12350	COG2202	Pas domain
C4J97_RS12350	COG3920	Histidine kinase
C4J97_RS12375	COG0784	Response regulator, receiver
C4J97_RS12375	COG2198	Histidine kinase
C4J97_RS12375	COG2205	protein histidine kinase activity
C4J97_RS12390	COG1301	dicarboxylic acid transport
C4J97_RS12395	COG0583	DNA-binding transcription factor activity
C4J97_RS12400	COG1309	transcriptional regulator
C4J97_RS12405	COG1309	transcriptional regulator
C4J97_RS12410	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS12415	COG4221	oxidoreductase activity
C4J97_RS12420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4J97_RS12430	COG0596	Alpha beta hydrolase
C4J97_RS12445	COG0784	Response regulator, receiver
C4J97_RS12445	COG2205	protein histidine kinase activity
C4J97_RS12450	COG2197	response regulator
C4J97_RS12485	COG2814	Major facilitator Superfamily
C4J97_RS12500	COG1024	Enoyl-CoA hydratase
C4J97_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS12510	COG3320	Male sterility
C4J97_RS12510	COG1022	Amp-dependent synthetase and ligase
C4J97_RS12515	COG0183	Belongs to the thiolase family
C4J97_RS12535	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS12545	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS12550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4J97_RS12585	COG0531	amino acid
C4J97_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS12630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS12635	COG1846	Transcriptional regulator
C4J97_RS12645	COG3971	2-oxopent-4-enoate hydratase activity
C4J97_RS12650	COG2271	Major facilitator Superfamily
C4J97_RS12660	COG3384	dioxygenase
C4J97_RS12665	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS12685	COG1846	Transcriptional regulator
C4J97_RS12725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4J97_RS12760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J97_RS12770	COG0778	Nitroreductase
C4J97_RS12780	COG2226	methyltransferase
C4J97_RS12780	COG2867	negative regulation of translational initiation
C4J97_RS12790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4J97_RS12795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J97_RS12810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J97_RS12810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J97_RS12825	COG0604	alcohol dehydrogenase
C4J97_RS12825	COG3321	synthase
C4J97_RS12825	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS12830	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS12840	COG3254	rhamnose metabolic process
C4J97_RS12850	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS12860	COG4948	Mandelate Racemase Muconate Lactonizing
C4J97_RS12865	COG2271	Major facilitator Superfamily
C4J97_RS12890	COG0583	DNA-binding transcription factor activity
C4J97_RS12905	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS12905	COG3321	synthase
C4J97_RS12905	COG0604	alcohol dehydrogenase
C4J97_RS12935	COG0210	DNA helicase
C4J97_RS12980	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J97_RS12995	COG0513	Belongs to the DEAD box helicase family
C4J97_RS13005	COG2308	Evidence 4 Homologs of previously reported genes of
C4J97_RS13040	COG0784	Response regulator, receiver
C4J97_RS13045	COG2202	Pas domain
C4J97_RS13045	COG2205	protein histidine kinase activity
C4J97_RS13055	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J97_RS13060	COG1879	ABC-type sugar transport system periplasmic component
C4J97_RS13065	COG1609	Transcriptional regulator
C4J97_RS13070	COG1070	Carbohydrate kinase
C4J97_RS13075	COG1522	sequence-specific DNA binding
C4J97_RS13085	COG0826	peptidase U32
C4J97_RS13100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J97_RS13105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS13110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J97_RS13120	COG0583	DNA-binding transcription factor activity
C4J97_RS13150	COG0583	DNA-binding transcription factor activity
C4J97_RS13155	COG3321	synthase
C4J97_RS13155	COG0604	alcohol dehydrogenase
C4J97_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS13160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J97_RS13160	COG1024	Enoyl-CoA hydratase
C4J97_RS13165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J97_RS13240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J97_RS13270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J97_RS13270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J97_RS13285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4J97_RS13290	COG1349	DNA-binding transcription factor activity
C4J97_RS13300	COG0738	Major facilitator superfamily
C4J97_RS13315	COG2814	Major facilitator Superfamily
C4J97_RS13320	COG4974	Belongs to the 'phage' integrase family
C4J97_RS13330	COG0463	Glycosyl transferase, family 2
C4J97_RS13335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J97_RS13335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J97_RS13340	COG0726	polysaccharide deacetylase
C4J97_RS13345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J97_RS13350	COG2076	Multidrug Resistance protein
C4J97_RS13355	COG2076	Multidrug Resistance protein
C4J97_RS13385	COG2124	cytochrome p450
C4J97_RS13390	COG0657	acetylesterase activity
C4J97_RS13395	COG1024	Enoyl-CoA hydratase
C4J97_RS13400	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS13405	COG1024	Enoyl-CoA hydratase
C4J97_RS13410	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS13425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J97_RS13435	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J97_RS13455	COG5002	protein histidine kinase activity
C4J97_RS13455	COG2205	protein histidine kinase activity
C4J97_RS13455	COG0784	Response regulator, receiver
C4J97_RS13465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J97_RS13470	COG0784	Response regulator, receiver
C4J97_RS13470	COG2205	protein histidine kinase activity
C4J97_RS13470	COG2198	Histidine kinase
C4J97_RS13500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4J97_RS13510	COG1794	racemase activity, acting on amino acids and derivatives
C4J97_RS13515	COG1247	-acetyltransferase
C4J97_RS13525	COG1929	Belongs to the glycerate kinase type-1 family
C4J97_RS13530	COG3835	regulator
C4J97_RS13535	COG2271	Major facilitator Superfamily
C4J97_RS13550	COG0583	DNA-binding transcription factor activity
C4J97_RS13555	COG0667	Aldo Keto reductase
C4J97_RS13575	COG2200	EAL domain
C4J97_RS13640	COG3258	Cytochrome c
C4J97_RS13645	COG2863	cytochrome
C4J97_RS13660	COG3145	DNA-N1-methyladenine dioxygenase activity
C4J97_RS13665	COG2169	Transcriptional regulator
C4J97_RS13665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J97_RS13685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4J97_RS13710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4J97_RS13770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J97_RS13770	COG0473	3-isopropylmalate dehydrogenase activity
C4J97_RS13775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J97_RS13815	COG2207	Transcriptional regulator
C4J97_RS13815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J97_RS13820	COG3938	Belongs to the proline racemase family
C4J97_RS13825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J97_RS13830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS13860	COG2366	antibiotic biosynthetic process
C4J97_RS13880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J97_RS13885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS13890	COG1116	anion transmembrane transporter activity
C4J97_RS13910	COG0583	DNA-binding transcription factor activity
C4J97_RS13915	COG0667	Aldo Keto reductase
C4J97_RS13930	COG1238	metal cluster binding
C4J97_RS13935	COG0596	Alpha beta hydrolase
C4J97_RS13940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J97_RS13945	COG0297	glycogen (starch) synthase activity
C4J97_RS13950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J97_RS13955	COG1640	4-alpha-glucanotransferase
C4J97_RS14005	COG0840	transmembrane signaling receptor activity
C4J97_RS14035	COG5002	protein histidine kinase activity
C4J97_RS14050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4J97_RS14185	COG2814	Major facilitator Superfamily
C4J97_RS14195	COG0626	cystathionine gamma-synthase activity
C4J97_RS14205	COG1944	ATP diphosphatase activity
C4J97_RS14210	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J97_RS14210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J97_RS14225	COG1309	transcriptional regulator
C4J97_RS14230	COG1335	isochorismatase
C4J97_RS14235	COG1051	belongs to the nudix hydrolase family
C4J97_RS14270	COG0583	DNA-binding transcription factor activity
C4J97_RS14280	COG2271	Major facilitator Superfamily
C4J97_RS14285	COG0519	Catalyzes the synthesis of GMP from XMP
C4J97_RS14295	COG1538	Outer membrane efflux protein
C4J97_RS14350	COG1175	transmembrane transport
C4J97_RS14370	COG1070	Carbohydrate kinase
C4J97_RS14390	COG0024	Methionine aminopeptidase
C4J97_RS14395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J97_RS14405	COG0730	response to heat
C4J97_RS14415	COG1595	DNA-templated transcription, initiation
C4J97_RS14425	COG2205	protein histidine kinase activity
C4J97_RS14430	COG0745	RESPONSE REGULATOR receiver
C4J97_RS14435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS14440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J97_RS14460	COG1609	Transcriptional regulator
C4J97_RS14470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J97_RS14490	COG2233	PERMEase
C4J97_RS14510	COG0583	DNA-binding transcription factor activity
C4J97_RS14525	COG3385	transposase activity
C4J97_RS14600	COG0561	phosphatase activity
C4J97_RS14605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4J97_RS14610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J97_RS14615	COG2194	sulfuric ester hydrolase activity
C4J97_RS14635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J97_RS14640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4J97_RS14655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J97_RS14660	COG3842	ATPase activity
C4J97_RS14670	COG1175	transmembrane transport
C4J97_RS14680	COG1609	Transcriptional regulator
C4J97_RS14690	COG0019	diaminopimelate decarboxylase activity
C4J97_RS14700	COG0420	3'-5' exonuclease activity
C4J97_RS14720	COG2706	6-phosphogluconolactonase activity
C4J97_RS14740	COG0673	inositol 2-dehydrogenase activity
C4J97_RS14750	COG0318	PFAM AMP-dependent synthetase and ligase
C4J97_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS14775	COG2067	long-chain fatty acid transport protein
C4J97_RS14795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J97_RS14820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4J97_RS14835	COG0515	serine threonine protein kinase
C4J97_RS14840	COG0631	protein serine/threonine phosphatase activity
C4J97_RS14875	COG2204	response regulator
C4J97_RS14920	COG0656	L-ascorbic acid biosynthetic process
C4J97_RS14930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J97_RS14935	COG4166	transmembrane transport
C4J97_RS14940	COG4174	ABC transporter (Permease)
C4J97_RS14945	COG4239	(ABC) transporter, permease
C4J97_RS14950	COG4172	Belongs to the ABC transporter superfamily
C4J97_RS14965	COG2610	gluconate transmembrane transporter activity
C4J97_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS14975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J97_RS14985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J97_RS14990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J97_RS15015	COG0765	amino acid transport
C4J97_RS15020	COG0765	amino acid transport
C4J97_RS15040	COG1253	flavin adenine dinucleotide binding
C4J97_RS15045	COG2072	flavoprotein involved in K transport
C4J97_RS15065	COG2066	Belongs to the glutaminase family
C4J97_RS15080	COG3385	transposase activity
C4J97_RS15090	COG4191	Histidine kinase
C4J97_RS15090	COG0784	Response regulator, receiver
C4J97_RS15095	COG0587	DNA-directed DNA polymerase activity
C4J97_RS15110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4J97_RS15115	COG0494	nUDIX hydrolase
C4J97_RS15125	COG1304	FMN binding
C4J97_RS15150	COG0693	protein deglycase activity
C4J97_RS15175	COG1999	signal sequence binding
C4J97_RS15205	COG0616	signal peptide processing
C4J97_RS15235	COG5383	Protein conserved in bacteria
C4J97_RS15240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS15240	COG2022	thiamine diphosphate biosynthetic process
C4J97_RS15245	COG2264	protein methyltransferase activity
C4J97_RS15250	COG2962	Rard protein
C4J97_RS15280	COG2814	Major facilitator Superfamily
C4J97_RS15285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS15290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J97_RS15335	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J97_RS15360	COG0577	efflux transmembrane transporter activity
C4J97_RS15360	COG1136	(ABC) transporter
C4J97_RS15365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS15425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS15430	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J97_RS15435	COG3958	Transketolase
C4J97_RS15440	COG3959	Transketolase, thiamine diphosphate binding domain
C4J97_RS15445	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J97_RS15450	COG1879	ABC-type sugar transport system periplasmic component
C4J97_RS15455	COG1129	ABC transporter
C4J97_RS15460	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS15475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J97_RS15480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J97_RS15485	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4J97_RS15495	COG2814	Major facilitator Superfamily
C4J97_RS15515	COG1063	alcohol dehydrogenase
C4J97_RS15550	COG0395	ABC-type sugar transport system, permease component
C4J97_RS15560	COG3842	ATPase activity
C4J97_RS15565	COG3842	ATPase activity
C4J97_RS15570	COG3284	Transcriptional regulator
C4J97_RS15615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4J97_RS15620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J97_RS15625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4J97_RS15630	COG2835	tetraacyldisaccharide 4'-kinase activity
C4J97_RS15635	COG1663	tetraacyldisaccharide 4'-kinase activity
C4J97_RS15640	COG0848	biopolymer transport protein
C4J97_RS15645	COG0811	peptide transport
C4J97_RS15650	COG0658	competence protein
C4J97_RS15650	COG2333	competence protein COMEC
C4J97_RS15670	COG0784	Response regulator, receiver
C4J97_RS15670	COG2205	protein histidine kinase activity
C4J97_RS15670	COG5002	protein histidine kinase activity
C4J97_RS15675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J97_RS15695	COG1393	Belongs to the ArsC family
C4J97_RS15715	COG0037	tRNA processing
C4J97_RS15725	COG3091	SprT-like family
C4J97_RS15730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J97_RS15750	COG2920	part of a sulfur-relay system
C4J97_RS15760	COG0435	Glutathione S-transferase
C4J97_RS15765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J97_RS15765	COG1648	precorrin-2 dehydrogenase activity
C4J97_RS15770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4J97_RS15775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J97_RS15780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4J97_RS15785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4J97_RS15790	COG1674	ftsk spoiiie
C4J97_RS15795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4J97_RS15800	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4J97_RS15805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4J97_RS15810	COG0542	response to heat
C4J97_RS15815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4J97_RS15820	COG1278	Cold shock
C4J97_RS15840	COG0482	sulfurtransferase activity
C4J97_RS15845	COG2915	High frequency lysogenization protein hflD homolog
C4J97_RS15855	COG2850	peptidyl-arginine hydroxylation
C4J97_RS15860	COG2153	protein acetylation
C4J97_RS15870	COG2224	Isocitrate lyase
C4J97_RS15875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J97_RS15880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J97_RS15885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J97_RS15885	COG0649	NAD binding
C4J97_RS15900	COG1034	ATP synthesis coupled electron transport
C4J97_RS15905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J97_RS15910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J97_RS15920	COG0713	ATP synthesis coupled electron transport
C4J97_RS15935	COG1007	ATP synthesis coupled electron transport
C4J97_RS15940	COG2944	sequence-specific DNA binding
C4J97_RS15970	COG2814	Major facilitator Superfamily
C4J97_RS15995	COG1136	(ABC) transporter
C4J97_RS15995	COG0577	efflux transmembrane transporter activity
C4J97_RS16000	COG0577	efflux transmembrane transporter activity
C4J97_RS16000	COG1136	(ABC) transporter
C4J97_RS16010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS16075	COG2111	Na H antiporter
C4J97_RS16075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J97_RS16080	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J97_RS16085	COG0651	ATP synthesis coupled electron transport
C4J97_RS16095	COG2212	antiporter activity
C4J97_RS16100	COG1320	monovalent cation:proton antiporter activity
C4J97_RS16125	COG0215	cysteine-tRNA ligase activity
C4J97_RS16130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J97_RS16140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J97_RS16145	COG2814	Major facilitator Superfamily
C4J97_RS16150	COG1566	PFAM secretion protein HlyD family protein
C4J97_RS16160	COG1846	Transcriptional regulator
C4J97_RS16170	COG0729	surface antigen
C4J97_RS16180	COG0708	Exodeoxyribonuclease III
C4J97_RS16185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4J97_RS16190	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS16200	COG0789	Transcriptional regulator
C4J97_RS16210	COG0318	PFAM AMP-dependent synthetase and ligase
C4J97_RS16215	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS16220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J97_RS16245	COG2866	Carboxypeptidase
C4J97_RS16250	COG3038	cytochrome b561
C4J97_RS16305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J97_RS16320	COG0217	transcriptional regulatory protein
C4J97_RS16325	COG0583	DNA-binding transcription factor activity
C4J97_RS16330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J97_RS16335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J97_RS16340	COG3038	cytochrome b561
C4J97_RS16350	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS16350	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J97_RS16365	COG1846	Transcriptional regulator
C4J97_RS16370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J97_RS16380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J97_RS16385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J97_RS16390	COG0776	regulation of translation
C4J97_RS16395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J97_RS16400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4J97_RS16405	COG0740	serine-type endopeptidase activity
C4J97_RS16410	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4J97_RS16435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4J97_RS16440	COG1686	Belongs to the peptidase S11 family
C4J97_RS16480	COG1953	Uracil, thiamine, allantoin
C4J97_RS16490	COG0493	'glutamate synthase
C4J97_RS16500	COG1309	transcriptional regulator
C4J97_RS16520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J97_RS16530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4J97_RS16560	COG0471	metal ion transport
C4J97_RS16575	COG0640	Transcriptional regulator
C4J97_RS16585	COG1522	sequence-specific DNA binding
C4J97_RS16590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J97_RS16595	COG0022	dehydrogenase e1 component
C4J97_RS16605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J97_RS16610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J97_RS16615	COG0456	acetyltransferase
C4J97_RS16640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS16645	COG0577	efflux transmembrane transporter activity
C4J97_RS16645	COG1136	(ABC) transporter
C4J97_RS16700	COG0406	alpha-ribazole phosphatase activity
C4J97_RS16705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J97_RS16710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J97_RS16745	COG0583	DNA-binding transcription factor activity
C4J97_RS16755	COG0625	glutathione transferase activity
C4J97_RS16760	COG0667	Aldo Keto reductase
C4J97_RS16795	COG1231	oxidoreductase activity
C4J97_RS16800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS16805	COG1126	abc transporter atp-binding protein
C4J97_RS16830	COG1450	Type ii and iii secretion system protein
C4J97_RS16850	COG3156	type II secretion system protein K
C4J97_RS16855	COG2165	general secretion pathway protein
C4J97_RS16865	COG2165	general secretion pathway protein
C4J97_RS16870	COG2165	general secretion pathway protein
C4J97_RS16875	COG1459	type II secretion system
C4J97_RS16880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J97_RS16890	COG1472	Belongs to the glycosyl hydrolase 3 family
C4J97_RS16900	COG3415	Transposase
C4J97_RS16900	COG2801	Transposase and inactivated derivatives
C4J97_RS16925	COG4774	siderophore transport
C4J97_RS16930	COG2199	diguanylate cyclase activity
C4J97_RS16930	COG2202	Pas domain
C4J97_RS16930	COG2200	EAL domain
C4J97_RS16980	COG1396	sequence-specific DNA binding
C4J97_RS16990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J97_RS17000	COG2271	Major facilitator Superfamily
C4J97_RS17010	COG0583	DNA-binding transcription factor activity
C4J97_RS17020	COG0129	dihydroxy-acid dehydratase activity
C4J97_RS17085	COG0776	regulation of translation
C4J97_RS17090	COG0072	phenylalanine-tRNA ligase activity
C4J97_RS17095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J97_RS17100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4J97_RS17105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4J97_RS17110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4J97_RS17115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J97_RS17125	COG1278	Cold shock
C4J97_RS17150	COG1869	D-ribose catabolic process
C4J97_RS17155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J97_RS17160	COG1609	Transcriptional regulator
C4J97_RS17165	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J97_RS17170	COG1129	ABC transporter
C4J97_RS17175	COG1879	ABC-type sugar transport system periplasmic component
C4J97_RS17200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J97_RS17210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J97_RS17225	COG0642	Histidine kinase
C4J97_RS17255	COG2026	Addiction module toxin, RelE StbE family
C4J97_RS17285	COG2135	peptidase activity
C4J97_RS17340	COG1432	Conserved Protein
C4J97_RS17645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J97_RS17710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS17745	COG1286	toxin biosynthetic process
C4J97_RS17750	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J97_RS17755	COG0285	dihydrofolate synthase activity
C4J97_RS17760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4J97_RS17765	COG0135	phosphoribosylanthranilate isomerase activity
C4J97_RS17790	COG0473	3-isopropylmalate dehydrogenase activity
C4J97_RS17795	COG2226	methyltransferase
C4J97_RS17800	COG0066	3-isopropylmalate dehydratase activity
C4J97_RS17805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J97_RS17830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J97_RS17870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J97_RS17875	COG0556	nucleotide-excision repair
C4J97_RS17890	COG3385	transposase activity
C4J97_RS17900	COG0583	DNA-binding transcription factor activity
C4J97_RS17905	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS17925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J97_RS17930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J97_RS17935	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J97_RS17950	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4J97_RS18045	COG0477	Major facilitator Superfamily
C4J97_RS18075	COG0840	transmembrane signaling receptor activity
C4J97_RS18080	COG2384	SAM-dependent methyltransferase
C4J97_RS18085	COG2186	Transcriptional regulator
C4J97_RS18105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C4J97_RS18115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J97_RS18135	COG2391	methyltransferase activity
C4J97_RS18180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J97_RS18190	COG0583	DNA-binding transcription factor activity
C4J97_RS18195	COG1304	FMN binding
C4J97_RS18210	COG5001	Diguanylate cyclase
C4J97_RS18210	COG5002	protein histidine kinase activity
C4J97_RS18220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C4J97_RS18225	COG1054	Belongs to the UPF0176 family
C4J97_RS18265	COG0114	fumarate hydratase activity
C4J97_RS18275	COG0697	spore germination
C4J97_RS18285	COG3539	Fimbrial protein
C4J97_RS18290	COG3539	Fimbrial protein
C4J97_RS18305	COG3121	Chaperone
C4J97_RS18310	COG3188	usher protein
C4J97_RS18325	COG0183	Belongs to the thiolase family
C4J97_RS18330	COG2326	polyphosphate kinase activity
C4J97_RS18335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4J97_RS18335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS18345	COG0367	asparagine synthase
C4J97_RS18350	COG0189	ligase activity
C4J97_RS18350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J97_RS18360	COG3089	Belongs to the UPF0270 family
C4J97_RS18365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J97_RS18380	COG1368	sulfuric ester hydrolase activity
C4J97_RS18405	COG2197	response regulator
C4J97_RS18420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4J97_RS18425	COG1073	alpha beta
C4J97_RS18450	COG2840	Smr protein MutS2
C4J97_RS18455	COG0302	gtp cyclohydrolase
C4J97_RS18475	COG2851	Citrate transporter
C4J97_RS18480	COG0583	DNA-binding transcription factor activity
C4J97_RS18485	COG0625	glutathione transferase activity
C4J97_RS18490	COG2252	PERMEase
C4J97_RS18525	COG4266	Belongs to the allantoicase family
C4J97_RS18530	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4J97_RS18540	COG2233	PERMEase
C4J97_RS18555	COG1560	Kdo2-lipid A biosynthetic process
C4J97_RS18560	COG0850	regulation of cytokinetic process
C4J97_RS18565	COG2894	cell division
C4J97_RS18570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4J97_RS18580	COG0564	pseudouridine synthase activity
C4J97_RS18585	COG1362	aminopeptidase activity
C4J97_RS18590	COG0668	transmembrane transport
C4J97_RS18625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J97_RS18660	COG2801	Transposase and inactivated derivatives
C4J97_RS18660	COG3415	Transposase
C4J97_RS18665	COG3385	transposase activity
C4J97_RS18675	COG1309	transcriptional regulator
C4J97_RS18685	COG3123	guanosine phosphorylase activity
C4J97_RS18690	COG0633	Ferredoxin
C4J97_RS18690	COG3217	Mosc domain protein beta barrel domain protein
C4J97_RS18705	COG3851	Histidine kinase
C4J97_RS18710	COG2197	response regulator
C4J97_RS18715	COG1597	lipid kinase activity
C4J97_RS18735	COG1192	Involved in chromosome partitioning
C4J97_RS18740	COG1360	Flagellar Motor Protein
C4J97_RS18745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4J97_RS18750	COG2201	protein-glutamate methylesterase activity
C4J97_RS18755	COG2198	Histidine kinase
C4J97_RS18755	COG0643	Histidine kinase
C4J97_RS18755	COG0784	Response regulator, receiver
C4J97_RS18760	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4J97_RS18900	COG1677	Flagellar hook-basal body complex protein FliE
C4J97_RS18935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4J97_RS18960	COG1256	bacterial-type flagellum assembly
C4J97_RS18970	COG1706	bacterial-type flagellum-dependent cell motility
C4J97_RS18975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4J97_RS18985	COG4787	bacterial-type flagellum-dependent cell motility
C4J97_RS19000	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4J97_RS19025	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4J97_RS19030	COG1846	Transcriptional regulator
C4J97_RS19035	COG0514	ATP-dependent DNA helicase (RecQ)
C4J97_RS19045	COG2832	Protein of unknown function (DUF454)
C4J97_RS19050	COG5002	protein histidine kinase activity
C4J97_RS19050	COG0784	Response regulator, receiver
C4J97_RS19090	COG1846	Transcriptional regulator
C4J97_RS19095	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4J97_RS19100	COG0406	alpha-ribazole phosphatase activity
C4J97_RS19105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J97_RS19120	COG1492	cobalamin metabolic process
C4J97_RS19130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4J97_RS19135	COG0778	Nitroreductase
C4J97_RS19140	COG1797	cobyrinic acid a,c-diamide synthase activity
C4J97_RS19155	COG0791	NLP P60 protein
C4J97_RS19160	COG0791	NLP P60 protein
C4J97_RS19165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J97_RS19170	COG0628	permease
C4J97_RS19180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4J97_RS19185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4J97_RS19200	COG4264	IucA IucC family
C4J97_RS19205	COG2814	Major facilitator Superfamily
C4J97_RS19215	COG3122	Protein conserved in bacteria
C4J97_RS19220	COG3956	TIGRFAM MazG family protein
C4J97_RS19225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J97_RS19230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J97_RS19245	COG0583	DNA-binding transcription factor activity
C4J97_RS19255	COG1953	Uracil, thiamine, allantoin
C4J97_RS19265	COG2996	Protein conserved in bacteria
C4J97_RS19295	COG0513	Belongs to the DEAD box helicase family
C4J97_RS19300	COG0668	transmembrane transport
C4J97_RS19345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J97_RS19370	COG1132	(ABC) transporter
C4J97_RS19390	COG2188	Transcriptional regulator
C4J97_RS19400	COG1595	DNA-templated transcription, initiation
C4J97_RS19410	COG1643	Atp-dependent helicase
C4J97_RS19415	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4J97_RS19435	COG0840	transmembrane signaling receptor activity
C4J97_RS19445	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J97_RS19470	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J97_RS19485	COG2010	Cytochrome c
C4J97_RS19500	COG0348	domain, Protein
C4J97_RS19535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J97_RS19540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J97_RS19545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4J97_RS19550	COG2130	NADP-dependent
C4J97_RS19555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4J97_RS19560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4J97_RS19570	COG0583	DNA-binding transcription factor activity
C4J97_RS19605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J97_RS19610	COG3115	cell septum assembly
C4J97_RS19630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J97_RS19640	COG0402	S-adenosylhomocysteine deaminase activity
C4J97_RS19645	COG1802	Transcriptional regulator
C4J97_RS19655	COG3135	benzoate transporter
C4J97_RS19660	COG3171	Protein conserved in bacteria
C4J97_RS19675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J97_RS19675	COG0116	Belongs to the methyltransferase superfamily
C4J97_RS19680	COG3130	regulation of translation
C4J97_RS19685	COG0167	dihydroorotate dehydrogenase activity
C4J97_RS19700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J97_RS19710	COG1116	anion transmembrane transporter activity
C4J97_RS19710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS19715	COG3707	response regulator
C4J97_RS19720	COG2223	nitrite transmembrane transporter activity
C4J97_RS19730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J97_RS19735	COG2146	nitrite reductase [NAD(P)H] activity
C4J97_RS19740	COG0243	molybdopterin cofactor binding
C4J97_RS19745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J97_RS19750	COG2885	chlorophyll binding
C4J97_RS19750	COG3047	cAMP biosynthetic process
C4J97_RS19775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J97_RS19790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4J97_RS19795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J97_RS19810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J97_RS19815	COG1045	serine acetyltransferase
C4J97_RS19820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J97_RS19835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4J97_RS19840	COG0372	Belongs to the citrate synthase family
C4J97_RS19850	COG1802	Transcriptional regulator
C4J97_RS19855	COG4067	protein conserved in archaea
C4J97_RS19855	COG0189	ligase activity
C4J97_RS19865	COG0189	ligase activity
C4J97_RS19870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J97_RS19885	COG0560	Phosphoserine phosphatase
C4J97_RS19895	COG1953	Uracil, thiamine, allantoin
C4J97_RS19905	COG0583	DNA-binding transcription factor activity
C4J97_RS19910	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS19915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J97_RS19965	COG0586	Pfam SNARE associated Golgi protein
C4J97_RS19975	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J97_RS19975	COG1024	Enoyl-CoA hydratase
C4J97_RS19985	COG0598	Magnesium transport protein CorA
C4J97_RS19990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J97_RS19990	COG0519	Catalyzes the synthesis of GMP from XMP
C4J97_RS19995	COG1024	Enoyl-CoA hydratase
C4J97_RS19995	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J97_RS20000	COG0183	Belongs to the thiolase family
C4J97_RS20010	COG1305	Transglutaminase-like
C4J97_RS20015	COG2308	Evidence 4 Homologs of previously reported genes of
C4J97_RS20045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J97_RS20050	COG3047	cAMP biosynthetic process
C4J97_RS20050	COG2885	chlorophyll binding
C4J97_RS20080	COG2207	Transcriptional regulator
C4J97_RS20085	COG1064	alcohol dehydrogenase
C4J97_RS20090	COG1414	Transcriptional regulator
C4J97_RS20095	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J97_RS20100	COG1129	ABC transporter
C4J97_RS20105	COG1879	ABC-type sugar transport system periplasmic component
C4J97_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS20135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J97_RS20145	COG1397	ADP-ribosylglycohydrolase
C4J97_RS20150	COG2188	Transcriptional regulator
C4J97_RS20180	COG0084	hydrolase, TatD family'
C4J97_RS20190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J97_RS20195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4J97_RS20205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J97_RS20210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J97_RS20225	COG0416	fatty acid biosynthetic process
C4J97_RS20230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4J97_RS20235	COG1399	metal-binding, possibly nucleic acid-binding protein
C4J97_RS20240	COG0424	maF-like protein
C4J97_RS20260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J97_RS20260	COG0616	signal peptide processing
C4J97_RS20265	COG0546	phosphoglycolate phosphatase activity
C4J97_RS20275	COG1530	ribonuclease E activity
C4J97_RS20285	COG3608	succinylglutamate desuccinylase aspartoacylase
C4J97_RS20285	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4J97_RS20290	COG1301	dicarboxylic acid transport
C4J97_RS20295	COG4977	sequence-specific DNA binding
C4J97_RS20295	COG1917	Cupin 2, conserved barrel domain protein
C4J97_RS20315	COG2977	Belongs to the P-Pant transferase superfamily
C4J97_RS20320	COG2205	protein histidine kinase activity
C4J97_RS20325	COG0745	RESPONSE REGULATOR receiver
C4J97_RS20345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4J97_RS20355	COG1815	bacterial-type flagellum-dependent cell motility
C4J97_RS20360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J97_RS20365	COG0784	Response regulator, receiver
C4J97_RS20365	COG0835	chemotaxis
C4J97_RS20385	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4J97_RS20390	COG0477	Major facilitator Superfamily
C4J97_RS20440	COG2239	Acts as a magnesium transporter
C4J97_RS20460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J97_RS20465	COG0527	aspartate kinase activity
C4J97_RS20470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J97_RS20475	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4J97_RS20480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J97_RS20485	COG2988	succinylglutamate desuccinylase activity
C4J97_RS20495	COG3724	N-succinylarginine dihydrolase activity
C4J97_RS20500	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS20515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J97_RS20550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS20560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J97_RS20580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J97_RS20585	COG0326	Molecular chaperone. Has ATPase activity
C4J97_RS20655	COG0154	amidase activity
C4J97_RS20690	COG2329	Antibiotic biosynthesis monooxygenase
C4J97_RS20700	COG0584	glycerophosphoryl diester phosphodiesterase
C4J97_RS20720	COG0306	phosphate transporter
C4J97_RS20730	COG0583	DNA-binding transcription factor activity
C4J97_RS20735	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS20745	COG0583	DNA-binding transcription factor activity
C4J97_RS20765	COG0436	Aminotransferase
C4J97_RS20775	COG3265	gluconokinase activity
C4J97_RS20780	COG1609	Transcriptional regulator
C4J97_RS20810	COG2271	Major facilitator Superfamily
C4J97_RS20820	COG0583	DNA-binding transcription factor activity
C4J97_RS20830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS20845	COG0242	peptide deformylase activity
C4J97_RS20850	COG1295	ribonuclease BN
C4J97_RS20855	COG3237	CsbD-like
C4J97_RS20865	COG0318	PFAM AMP-dependent synthetase and ligase
C4J97_RS20870	COG0318	PFAM AMP-dependent synthetase and ligase
C4J97_RS20875	COG2267	carboxylic ester hydrolase activity
C4J97_RS20880	COG2030	dehydratase
C4J97_RS20895	COG3530	Putative quorum-sensing-regulated virulence factor
C4J97_RS20900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J97_RS20905	COG0800	Aldolase
C4J97_RS20920	COG1737	Transcriptional regulator
C4J97_RS20925	COG0676	glucose-6-phosphate 1-epimerase activity
C4J97_RS20935	COG3842	ATPase activity
C4J97_RS20945	COG1175	transmembrane transport
C4J97_RS20950	COG1653	transport
C4J97_RS20965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J97_RS20970	COG0583	DNA-binding transcription factor activity
C4J97_RS20980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4J97_RS21005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4J97_RS21035	COG1113	amino acid transport
C4J97_RS21060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4J97_RS21070	COG0009	L-threonylcarbamoyladenylate synthase
C4J97_RS21080	COG2917	probably involved in intracellular septation
C4J97_RS21085	COG2350	Protein conserved in bacteria
C4J97_RS21095	COG0745	RESPONSE REGULATOR receiver
C4J97_RS21105	COG0642	Histidine kinase
C4J97_RS21150	COG0509	glycine decarboxylation via glycine cleavage system
C4J97_RS21155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J97_RS21155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J97_RS21165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J97_RS21170	COG1278	Cold shock
C4J97_RS21180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4J97_RS21190	COG3916	Acyl-homoserine-lactone synthase
C4J97_RS21200	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J97_RS21200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J97_RS21205	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J97_RS21205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J97_RS21210	COG0287	Prephenate dehydrogenase
C4J97_RS21225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J97_RS21230	COG1535	isochorismatase
C4J97_RS21230	COG3433	isochorismatase activity
C4J97_RS21235	COG3433	isochorismatase activity
C4J97_RS21235	COG1535	isochorismatase
C4J97_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS21250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J97_RS21255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J97_RS21270	COG0602	queuosine metabolic process
C4J97_RS21275	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4J97_RS21280	COG2885	chlorophyll binding
C4J97_RS21285	COG0823	Involved in the tonB-independent uptake of proteins
C4J97_RS21305	COG0824	Thioesterase
C4J97_RS21315	COG2255	four-way junction helicase activity
C4J97_RS21320	COG0632	four-way junction helicase activity
C4J97_RS21325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4J97_RS21330	COG0217	transcriptional regulatory protein
C4J97_RS21335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4J97_RS21350	COG0783	Belongs to the Dps family
C4J97_RS21360	COG2900	Belongs to the SlyX family
C4J97_RS21375	COG0668	transmembrane transport
C4J97_RS21380	COG1666	GTP binding
C4J97_RS21390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS21390	COG4191	Histidine kinase
C4J97_RS21395	COG2096	Adenosyltransferase
C4J97_RS21405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4J97_RS21410	COG0653	protein targeting
C4J97_RS21420	COG0433	COG0433 Predicted ATPase
C4J97_RS21435	COG0438	transferase activity, transferring glycosyl groups
C4J97_RS21435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J97_RS21460	COG2925	Exonuclease
C4J97_RS21485	COG0714	Associated with various cellular activities
C4J97_RS21505	COG0469	pyruvate kinase activity
C4J97_RS21510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J97_RS21520	COG4191	Histidine kinase
C4J97_RS21530	COG0477	Major facilitator Superfamily
C4J97_RS21550	COG2207	Transcriptional regulator
C4J97_RS21580	COG1595	DNA-templated transcription, initiation
C4J97_RS21585	COG3712	iron ion homeostasis
C4J97_RS21590	COG4771	TonB-dependent receptor
C4J97_RS21600	COG2832	Protein of unknown function (DUF454)
C4J97_RS21605	COG0840	transmembrane signaling receptor activity
C4J97_RS21630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J97_RS21635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J97_RS21645	COG3642	lipopolysaccharide core region biosynthetic process
C4J97_RS21655	COG0642	Histidine kinase
C4J97_RS21665	COG0459	protein refolding
C4J97_RS21670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4J97_RS21695	COG2211	Major facilitator Superfamily
C4J97_RS21700	COG0442	prolyl-tRNA aminoacylation
C4J97_RS21710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4J97_RS21745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J97_RS21775	COG4974	Belongs to the 'phage' integrase family
C4J97_RS21785	COG0335	large ribosomal subunit rRNA binding
C4J97_RS21790	COG0336	Belongs to the RNA methyltransferase TrmD family
C4J97_RS21795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4J97_RS21800	COG0228	four-way junction DNA binding
C4J97_RS21805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4J97_RS21815	COG4536	flavin adenine dinucleotide binding
C4J97_RS21820	COG0477	Major facilitator Superfamily
C4J97_RS21825	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4J97_RS21845	COG0494	nUDIX hydrolase
C4J97_RS21860	COG2188	Transcriptional regulator
C4J97_RS21865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4J97_RS21870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J97_RS21875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J97_RS21875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J97_RS21880	COG2190	(PTS) system
C4J97_RS21880	COG1263	PTS System
C4J97_RS21880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J97_RS21895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4J97_RS21900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J97_RS21900	COG0047	phosphoribosylformylglycinamidine synthase activity
C4J97_RS21905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J97_RS21910	COG2190	(PTS) system
C4J97_RS21910	COG1263	PTS System
C4J97_RS21910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J97_RS21915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J97_RS21915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J97_RS21920	COG4580	involved in the transport of maltose and maltodextrins
C4J97_RS21925	COG0366	Alpha amylase catalytic
C4J97_RS21930	COG1263	PTS System
C4J97_RS21930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J97_RS21935	COG2188	Transcriptional regulator
C4J97_RS21955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J97_RS21955	COG0519	Catalyzes the synthesis of GMP from XMP
C4J97_RS21980	COG1570	exodeoxyribonuclease VII activity
C4J97_RS21985	COG0739	heme binding
C4J97_RS22000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J97_RS22005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J97_RS22010	COG0436	Aminotransferase
C4J97_RS22015	COG1160	GTP binding
C4J97_RS22030	COG0124	histidyl-tRNA synthetase
C4J97_RS22035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J97_RS22040	COG1426	Protein conserved in bacteria
C4J97_RS22050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4J97_RS22055	COG0105	UTP biosynthetic process
C4J97_RS22065	COG0633	Ferredoxin
C4J97_RS22070	COG0443	Heat shock 70 kDa protein
C4J97_RS22075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J97_RS22080	COG0316	Belongs to the HesB IscA family
C4J97_RS22090	COG1104	cysteine desulfurase activity
C4J97_RS22120	COG3134	Outer membrane lipoprotein
C4J97_RS22135	COG1862	Preprotein translocase
C4J97_RS22140	COG0343	queuine tRNA-ribosyltransferase activity
C4J97_RS22145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4J97_RS22170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J97_RS22180	COG0243	molybdopterin cofactor binding
C4J97_RS22185	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J97_RS22190	COG0697	spore germination
C4J97_RS22195	COG0583	DNA-binding transcription factor activity
C4J97_RS22235	COG4942	peptidase
C4J97_RS22245	COG1280	lysine exporter protein (LysE YggA)
C4J97_RS22300	COG4251	negative regulation of phosphorylation
C4J97_RS22310	COG3706	GGDEF domain
C4J97_RS22320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J97_RS22335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4J97_RS22340	COG0109	protoheme IX farnesyltransferase activity
C4J97_RS22350	COG1845	cytochrome c oxidase, subunit III
C4J97_RS22355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J97_RS22360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J97_RS22370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J97_RS22375	COG1017	nitric oxide dioxygenase activity
C4J97_RS22375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J97_RS22380	COG3604	Transcriptional regulator
C4J97_RS22390	COG2207	Transcriptional regulator
C4J97_RS22390	COG3708	Transcriptional regulator
C4J97_RS22395	COG2197	response regulator
C4J97_RS22410	COG1028	Short-chain dehydrogenase reductase Sdr
C4J97_RS22430	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J97_RS22440	COG0789	Transcriptional regulator
C4J97_RS22455	COG0302	gtp cyclohydrolase
C4J97_RS22460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J97_RS22475	COG0492	ferredoxin-NADP+ reductase activity
C4J97_RS22485	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4J97_RS22500	COG0386	Belongs to the glutathione peroxidase family
C4J97_RS22505	COG3045	CreA protein
C4J97_RS22510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4J97_RS22515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4J97_RS22520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4J97_RS22525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4J97_RS22530	COG0142	geranyltranstransferase activity
C4J97_RS22535	COG2824	Alkylphosphonate utilization operon protein PhnA
C4J97_RS22540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J97_RS22545	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J97_RS22550	COG0840	transmembrane signaling receptor activity
C4J97_RS22560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4J97_RS22570	COG2610	gluconate transmembrane transporter activity
C4J97_RS22580	COG0659	secondary active sulfate transmembrane transporter activity
C4J97_RS22590	COG0583	DNA-binding transcription factor activity
C4J97_RS22600	COG0583	DNA-binding transcription factor activity
C4J97_RS22605	COG1113	amino acid transport
C4J97_RS22615	COG1522	sequence-specific DNA binding
C4J97_RS22620	COG3485	protocatechuate 3,4-dioxygenase
C4J97_RS22625	COG4829	muconolactone delta-isomerase
C4J97_RS22630	COG4948	Mandelate Racemase Muconate Lactonizing
C4J97_RS22645	COG4638	Rieske (2fe-2S)
C4J97_RS22650	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4J97_RS22655	COG0543	2 iron, 2 sulfur cluster binding
C4J97_RS22655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J97_RS22660	COG1113	amino acid transport
C4J97_RS22665	COG3483	tryptophan 2,3-dioxygenase activity
C4J97_RS22670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4J97_RS22720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J97_RS22725	COG1074	ATP-dependent DNA helicase activity
C4J97_RS22730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4J97_RS22765	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4J97_RS22770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J97_RS22775	COG1183	phosphatidylcholine synthase activity
C4J97_RS22780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4J97_RS22790	COG0028	Belongs to the TPP enzyme family
C4J97_RS22795	COG3098	single-species biofilm formation
C4J97_RS22805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J97_RS22825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J97_RS22830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J97_RS22835	COG4558	Periplasmic binding protein
C4J97_RS22845	COG1489	DNA binding
C4J97_RS22850	COG0436	Aminotransferase
C4J97_RS22855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4J97_RS22860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J97_RS22870	COG4191	Histidine kinase
C4J97_RS22895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J97_RS22900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4J97_RS22905	COG0166	Belongs to the GPI family
C4J97_RS22910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J97_RS22920	COG2823	Periplasmic or secreted lipoprotein
C4J97_RS22925	COG1185	polyribonucleotide nucleotidyltransferase activity
C4J97_RS22930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4J97_RS22935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4J97_RS22940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4J97_RS22945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4J97_RS22950	COG0195	Participates in both transcription termination and antitermination
C4J97_RS22955	COG0779	Required for maturation of 30S ribosomal subunits
C4J97_RS22970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J97_RS22975	COG0149	triose-phosphate isomerase activity
C4J97_RS22980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J97_RS22985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J97_RS22995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4J97_RS23010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J97_RS23015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4J97_RS23020	COG0505	Belongs to the CarA family
C4J97_RS23025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4J97_RS23030	COG0484	heat shock protein binding
C4J97_RS23035	COG0443	Heat shock 70 kDa protein
C4J97_RS23040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4J97_RS23045	COG0497	DNA recombination
C4J97_RS23050	COG0735	belongs to the Fur family
C4J97_RS23055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J97_RS23060	COG2914	Belongs to the UPF0125 (RnfH) family
C4J97_RS23070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4J97_RS23075	COG2186	Transcriptional regulator
C4J97_RS23080	COG1620	l-lactate permease
C4J97_RS23125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J97_RS23130	COG0583	DNA-binding transcription factor activity
C4J97_RS23150	COG2862	Uncharacterized protein family, UPF0114
C4J97_RS23165	COG1067	ATP-dependent peptidase activity
C4J97_RS23195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J97_RS23205	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J97_RS23230	COG2814	Major facilitator Superfamily
C4J97_RS23235	COG0583	DNA-binding transcription factor activity
C4J97_RS23240	COG0488	(ABC) transporter
C4J97_RS23250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J97_RS23255	COG0523	cobalamin synthesis protein
C4J97_RS23260	COG2879	small protein
C4J97_RS23265	COG1966	Carbon starvation protein
C4J97_RS23285	COG1970	mechanosensitive ion channel activity
C4J97_RS23295	COG2197	response regulator
C4J97_RS23300	COG2813	Specifically methylates the guanine in position
C4J97_RS23310	COG1294	oxidase, subunit
C4J97_RS23315	COG1271	oxidase subunit
C4J97_RS23330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J97_RS23335	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4J97_RS23340	COG2080	2 iron, 2 sulfur cluster binding
C4J97_RS23350	COG2252	PERMEase
C4J97_RS23355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J97_RS23365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J97_RS23370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J97_RS23375	COG1309	transcriptional regulator
C4J97_RS23380	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4J97_RS23380	COG1082	Xylose isomerase domain protein TIM barrel
C4J97_RS23385	COG0477	Major facilitator Superfamily
C4J97_RS23400	COG2321	neutral zinc metallopeptidase
C4J97_RS23415	COG1946	Acyl-CoA thioesterase
C4J97_RS23425	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4J97_RS23435	COG0513	Belongs to the DEAD box helicase family
C4J97_RS23440	COG0697	spore germination
C4J97_RS23445	COG1522	sequence-specific DNA binding
C4J97_RS23490	COG3385	transposase activity
C4J97_RS23495	COG1643	Atp-dependent helicase
C4J97_RS23515	COG1522	sequence-specific DNA binding
C4J97_RS23530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J97_RS23535	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS23545	COG0351	phosphomethylpyrimidine kinase
C4J97_RS23550	COG0352	thiamine-phosphate diphosphorylase activity
C4J97_RS23555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J97_RS23580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS23595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J97_RS23600	COG1702	phosphate starvation-inducible protein PhoH
C4J97_RS23605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4J97_RS23610	COG4535	Mg2 and Co2 transporter CorC
C4J97_RS23615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4J97_RS23630	COG0495	leucyl-tRNA aminoacylation
C4J97_RS23640	COG1466	dna polymerase III delta subunit
C4J97_RS23650	COG2951	lytic endotransglycosylase activity
C4J97_RS23655	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4J97_RS23660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4J97_RS23665	COG0321	lipoyl(octanoyl) transferase activity
C4J97_RS23670	COG2921	Belongs to the UPF0250 family
C4J97_RS23675	COG1686	Belongs to the peptidase S11 family
C4J97_RS23685	COG2951	lytic endotransglycosylase activity
C4J97_RS23690	COG0772	Belongs to the SEDS family
C4J97_RS23695	COG0768	penicillin binding
C4J97_RS23700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4J97_RS23710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4J97_RS23715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4J97_RS23720	COG2094	Belongs to the DNA glycosylase MPG family
C4J97_RS23725	COG0586	Pfam SNARE associated Golgi protein
C4J97_RS23740	COG1346	cytolysis
C4J97_RS23760	COG0702	epimerase
C4J97_RS23775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J97_RS23790	COG3284	Transcriptional regulator
C4J97_RS23800	COG0531	amino acid
C4J97_RS23805	COG4303	Ethanolamine ammonia lyase large subunit
C4J97_RS23810	COG4302	ethanolamine ammonia-lyase activity
C4J97_RS23815	COG0456	acetyltransferase
C4J97_RS23820	COG0586	Pfam SNARE associated Golgi protein
C4J97_RS23825	COG3228	Belongs to the MtfA family
C4J97_RS23830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4J97_RS23850	COG1335	isochorismatase
C4J97_RS23865	COG3209	COG3209 Rhs family protein
C4J97_RS23880	COG1722	exodeoxyribonuclease VII activity
C4J97_RS23885	COG0142	geranyltranstransferase activity
C4J97_RS23890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J97_RS23915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J97_RS23925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4J97_RS23930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4J97_RS23935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J97_RS23950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J97_RS23950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J97_RS23955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4J97_RS23965	COG2264	protein methyltransferase activity
C4J97_RS23970	COG3118	belongs to the thioredoxin family
C4J97_RS24010	COG1201	RNA secondary structure unwinding
C4J97_RS24015	COG0668	transmembrane transport
C4J97_RS24025	COG3568	Endonuclease Exonuclease Phosphatase
C4J97_RS24030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J97_RS24035	COG0392	lysyltransferase activity
C4J97_RS24055	COG1335	isochorismatase
C4J97_RS24060	COG4106	trans-aconitate 2-methyltransferase activity
C4J97_RS24065	COG0629	single-stranded DNA binding
C4J97_RS24070	COG2814	Major facilitator Superfamily
C4J97_RS24075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J97_RS24080	COG2193	ferroxidase activity
C4J97_RS24090	COG0203	ribosomal protein L17
C4J97_RS24095	COG0202	RNA polymerase activity
C4J97_RS24100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4J97_RS24105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4J97_RS24110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4J97_RS24115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4J97_RS24125	COG0200	Binds to the 23S rRNA
C4J97_RS24130	COG1841	ribosomal large subunit assembly
C4J97_RS24135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4J97_RS24140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4J97_RS24145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4J97_RS24150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4J97_RS24155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J97_RS24160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4J97_RS24165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4J97_RS24170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4J97_RS24175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4J97_RS24180	COG0255	Belongs to the universal ribosomal protein uL29 family
C4J97_RS24185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4J97_RS24190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4J97_RS24195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4J97_RS24200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4J97_RS24205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4J97_RS24210	COG0089	rRNA binding
C4J97_RS24215	COG0088	Forms part of the polypeptide exit tunnel
C4J97_RS24220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4J97_RS24225	COG0051	transcription antitermination factor activity, RNA binding
C4J97_RS24230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J97_RS24235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J97_RS24240	COG0049	tRNA binding
C4J97_RS24245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4J97_RS24250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4J97_RS24255	COG0085	RNA polymerase activity
C4J97_RS24260	COG0222	ribosome binding
C4J97_RS24265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4J97_RS24270	COG0081	regulation of translation
C4J97_RS24275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4J97_RS24315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4J97_RS24350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4J97_RS24360	COG0739	heme binding
C4J97_RS24365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4J97_RS24370	COG0316	Belongs to the HesB IscA family
C4J97_RS24375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4J97_RS24380	COG1981	membrane
C4J97_RS24395	COG4221	oxidoreductase activity
C4J97_RS24400	COG0537	adenosine 5'-monophosphoramidase activity
C4J97_RS24405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4J97_RS24410	COG1765	OsmC-like protein
C4J97_RS24425	COG0134	indole-3-glycerol-phosphate synthase activity
C4J97_RS24430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J97_RS24435	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J97_RS24445	COG3240	lipase activity
C4J97_RS24445	COG4625	pathogenesis
C4J97_RS24460	COG0546	phosphoglycolate phosphatase activity
C4J97_RS24465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4J97_RS24470	COG1454	alcohol dehydrogenase
C4J97_RS24480	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J97_RS24490	COG3842	ATPase activity
C4J97_RS24495	COG2197	response regulator
C4J97_RS24510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J97_RS24515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4J97_RS24520	COG3178	'Phosphotransferase
C4J97_RS24525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4J97_RS24530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J97_RS24535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4J97_RS24540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J97_RS24545	COG2967	ApaG domain
C4J97_RS24550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J97_RS24555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J97_RS24560	COG2766	serine protein kinase
C4J97_RS24565	COG2718	Belongs to the UPF0229 family
C4J97_RS24570	COG2719	SpoVR family
C4J97_RS24575	COG0617	tRNA 3'-terminal CCA addition
C4J97_RS24585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J97_RS24590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4J97_RS24595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4J97_RS24600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4J97_RS24605	COG0358	DNA primase activity
C4J97_RS24610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J97_RS24690	COG3237	CsbD-like
C4J97_RS24705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J97_RS24710	COG1025	Belongs to the peptidase M16 family
C4J97_RS24720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J97_RS24725	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4J97_RS24735	COG0535	radical SAM domain protein
C4J97_RS24750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J97_RS24755	COG0583	DNA-binding transcription factor activity
C4J97_RS24760	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS24765	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS24770	COG3706	GGDEF domain
C4J97_RS24775	COG1960	acyl-CoA dehydrogenase activity
C4J97_RS24795	COG1073	alpha beta
C4J97_RS24795	COG2226	methyltransferase
C4J97_RS24800	COG0156	8-amino-7-oxononanoate synthase activity
C4J97_RS24805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4J97_RS24815	COG2005	Transcriptional regulator
C4J97_RS24815	COG3585	molybdate ion transport
C4J97_RS24825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4J97_RS24840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4J97_RS24855	COG2176	DNA-directed DNA polymerase activity
C4J97_RS24860	COG1595	DNA-templated transcription, initiation
C4J97_RS24870	COG4774	siderophore transport
C4J97_RS24890	COG4452	Inner membrane protein CreD
C4J97_RS24895	COG2205	protein histidine kinase activity
C4J97_RS24900	COG0745	RESPONSE REGULATOR receiver
C4J97_RS24905	COG0189	ligase activity
C4J97_RS24905	COG4067	protein conserved in archaea
C4J97_RS24910	COG0204	Acyl-transferase
C4J97_RS24925	COG1063	alcohol dehydrogenase
C4J97_RS24955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J97_RS24980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J97_RS24980	COG1017	nitric oxide dioxygenase activity
C4J97_RS24990	COG4638	Rieske (2fe-2S)
C4J97_RS25000	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4J97_RS25005	COG0247	lactate metabolic process
C4J97_RS25005	COG2181	nitrate reductase activity
C4J97_RS25010	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J97_RS25010	COG1902	pentaerythritol trinitrate reductase activity
C4J97_RS25050	COG3246	L-lysine catabolic process to acetate
C4J97_RS25055	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J97_RS25075	COG1760	l-serine dehydratase
C4J97_RS25090	COG4175	Glycine betaine
C4J97_RS25095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J97_RS25100	COG1309	transcriptional regulator
C4J97_RS25105	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS25110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J97_RS25130	COG0477	Major facilitator Superfamily
C4J97_RS25135	COG0513	Belongs to the DEAD box helicase family
C4J97_RS25140	COG2081	HI0933 family
C4J97_RS25145	COG1289	transmembrane transporter activity
C4J97_RS25155	COG2153	protein acetylation
C4J97_RS25165	COG1451	nucleotide metabolic process
C4J97_RS25205	COG0126	phosphoglycerate kinase activity
C4J97_RS25210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4J97_RS25215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4J97_RS25220	COG0640	Transcriptional regulator
C4J97_RS25225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4J97_RS25230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J97_RS25235	COG1422	Protein of unknown function (DUF1090)
C4J97_RS25265	COG2116	formate transmembrane transporter activity
C4J97_RS25280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4J97_RS25285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4J97_RS25300	COG0513	Belongs to the DEAD box helicase family
C4J97_RS25305	COG2353	YceI-like domain
C4J97_RS25310	COG3038	cytochrome b561
C4J97_RS25320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4J97_RS25325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS25340	COG1272	protein, Hemolysin III
C4J97_RS25360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4J97_RS25380	COG3052	prosthetic group binding
C4J97_RS25385	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4J97_RS25405	COG3093	addiction module antidote protein HigA
C4J97_RS25415	COG2198	Histidine kinase
C4J97_RS25415	COG0643	Histidine kinase
C4J97_RS25415	COG0784	Response regulator, receiver
C4J97_RS25440	COG0189	ligase activity
C4J97_RS25450	COG1678	Uncharacterized ACR, COG1678
C4J97_RS25455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4J97_RS25460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4J97_RS25465	COG0540	Belongs to the ATCase OTCase family
C4J97_RS25470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J97_RS25485	COG0791	NLP P60 protein
C4J97_RS25510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J97_RS25515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J97_RS25515	COG2813	Specifically methylates the guanine in position
C4J97_RS25525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4J97_RS25530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4J97_RS25540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4J97_RS25545	COG2022	thiamine diphosphate biosynthetic process
C4J97_RS25555	COG2363	Small membrane protein
C4J97_RS25560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J97_RS25570	COG2177	Part of the ABC transporter FtsEX involved in
C4J97_RS25575	COG2884	Cell division ATP-binding protein ftsE
C4J97_RS25580	COG0552	protein localization to endoplasmic reticulum
C4J97_RS25585	COG0612	Peptidase, M16
C4J97_RS25590	COG0612	Peptidase, M16
C4J97_RS25595	COG0742	ribosomal rna small subunit methyltransferase
C4J97_RS25600	COG0429	hydrolase of the alpha beta-hydrolase fold
C4J97_RS25610	COG1309	transcriptional regulator
C4J97_RS25625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J97_RS25630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4J97_RS25635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J97_RS25640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J97_RS25650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J97_RS25655	COG2814	Major facilitator Superfamily
C4J97_RS25665	COG0129	dihydroxy-acid dehydratase activity
C4J97_RS25675	COG1823	symporter activity
C4J97_RS25690	COG1160	GTP binding
C4J97_RS25705	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J97_RS25710	COG1178	ABC-type Fe3 transport system permease component
C4J97_RS25715	COG3842	ATPase activity
C4J97_RS25720	COG0583	DNA-binding transcription factor activity
C4J97_RS25730	COG0789	Transcriptional regulator
C4J97_RS25735	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4J97_RS25740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4J97_RS25755	COG0494	nUDIX hydrolase
C4J97_RS25770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J97_RS25775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4J97_RS25780	COG2234	aminopeptidase activity
C4J97_RS25785	COG3204	pilus organization
C4J97_RS25790	COG3204	pilus organization
C4J97_RS25795	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J97_RS25800	COG0277	FAD linked oxidase domain protein
C4J97_RS25810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J97_RS25820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS25860	COG1177	transmembrane transport
C4J97_RS25865	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J97_RS25870	COG3842	ATPase activity
C4J97_RS25895	COG0174	glutamine synthetase
C4J97_RS25905	COG0174	glutamine synthetase
C4J97_RS25920	COG1116	anion transmembrane transporter activity
C4J97_RS25925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J97_RS25930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J97_RS25935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J97_RS25940	COG0431	NADPH-dependent FMN reductase
C4J97_RS25945	COG0450	alkyl hydroperoxide reductase
C4J97_RS25955	COG4521	taurine ABC transporter
C4J97_RS25960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J97_RS25960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4J97_RS25985	COG0330	HflC and HflK could
C4J97_RS26000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J97_RS26005	COG0509	glycine decarboxylation via glycine cleavage system
C4J97_RS26010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J97_RS26015	COG1178	ABC-type Fe3 transport system permease component
C4J97_RS26025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J97_RS26035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J97_RS26040	COG0006	proline dipeptidase activity
C4J97_RS26045	COG3079	Belongs to the UPF0149 family
C4J97_RS26065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4J97_RS26085	COG2271	Major facilitator Superfamily
C4J97_RS26105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4J97_RS26125	COG2186	Transcriptional regulator
C4J97_RS26130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS26135	COG0765	amino acid transport
C4J97_RS26140	COG0765	amino acid transport
C4J97_RS26145	COG1126	abc transporter atp-binding protein
C4J97_RS26155	COG3188	usher protein
C4J97_RS26160	COG3121	Chaperone
C4J97_RS26175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4J97_RS26185	COG0586	Pfam SNARE associated Golgi protein
C4J97_RS26195	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4J97_RS26200	COG1671	Belongs to the UPF0178 family
C4J97_RS26205	COG0672	)-iron permease
C4J97_RS26210	COG1280	lysine exporter protein (LysE YggA)
C4J97_RS26220	COG0488	(ABC) transporter
C4J97_RS26245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J97_RS26260	COG0181	hydroxymethylbilane synthase activity
C4J97_RS26270	COG0165	Argininosuccinate lyase
C4J97_RS26280	COG0625	glutathione transferase activity
C4J97_RS26300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J97_RS26310	COG1965	Belongs to the frataxin family
C4J97_RS26320	COG0019	diaminopimelate decarboxylase activity
C4J97_RS26325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J97_RS26335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J97_RS26340	COG1011	Hydrolase
C4J97_RS26355	COG0432	Pfam Uncharacterised protein family UPF0047
C4J97_RS26360	COG0004	ammonium transporteR
C4J97_RS26365	COG0347	Belongs to the P(II) protein family
C4J97_RS26375	COG0606	chelatase, subunit chli
C4J97_RS26380	COG0840	transmembrane signaling receptor activity
C4J97_RS26385	COG0583	DNA-binding transcription factor activity
C4J97_RS26390	COG0534	Mate efflux family protein
C4J97_RS26405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J97_RS26410	COG0427	acetyl-CoA hydrolase
C4J97_RS26425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4J97_RS26430	COG0251	oxidation-reduction process
C4J97_RS26435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS26450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J97_RS26460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J97_RS26465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J97_RS26470	COG1012	belongs to the aldehyde dehydrogenase family
C4J97_RS26480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J97_RS26485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J97_RS26490	COG0747	negative chemotaxis
C4J97_RS26495	COG2003	Belongs to the UPF0758 family
C4J97_RS26500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4J97_RS26505	COG0756	dUTP diphosphatase activity
C4J97_RS26515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J97_RS26520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J97_RS26525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4J97_RS26530	COG0708	Exodeoxyribonuclease III
C4J97_RS26540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4J97_RS26550	COG1561	YicC-like family, N-terminal region
C4J97_RS26555	COG0194	GDP metabolic process
C4J97_RS26560	COG1758	RNA polymerase activity
C4J97_RS26565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J97_RS26590	COG0848	biopolymer transport protein
C4J97_RS26600	COG0583	DNA-binding transcription factor activity
C4J97_RS26605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4J97_RS26665	COG1136	(ABC) transporter
C4J97_RS26670	COG2815	serine threonine protein kinase
C4J97_RS26670	COG0515	serine threonine protein kinase
C4J97_RS26675	COG0631	protein serine/threonine phosphatase activity
C4J97_RS26800	COG3161	chorismate lyase activity
C4J97_RS26805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4J97_RS26825	COG1253	flavin adenine dinucleotide binding
C4J97_RS26835	COG0704	Plays a role in the regulation of phosphate uptake
C4J97_RS26840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J97_RS26845	COG0573	inorganic phosphate transmembrane transporter activity
C4J97_RS26865	COG0477	Major facilitator Superfamily
C4J97_RS26870	COG1607	acyl-coa hydrolase
C4J97_RS26900	COG0583	DNA-binding transcription factor activity
C4J97_RS26905	COG1027	Aspartate ammonia-lyase
C4J97_RS26910	COG1115	amino acid carrier protein
C4J97_RS26915	COG0252	asparaginase activity
C4J97_RS26965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J97_RS26970	COG0765	amino acid transport
C4J97_RS26980	COG0511	ligase activity, forming carbon-carbon bonds
C4J97_RS26980	COG5016	pyruvate
C4J97_RS26985	COG0439	Biotin carboxylase
C4J97_RS26990	COG0583	DNA-binding transcription factor activity
C4J97_RS27005	COG3300	MHYT domain
C4J97_RS27005	COG5001	Diguanylate cyclase
C4J97_RS27030	COG4651	solute:proton antiporter activity
C4J97_RS27030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J97_RS27035	COG1607	acyl-coa hydrolase
C4J97_RS27040	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4J97_RS27050	COG0523	cobalamin synthesis protein
C4J97_RS27070	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J97_RS27075	COG1469	GTP cyclohydrolase I activity
C4J97_RS27080	COG1121	(ABC) transporter
C4J97_RS27100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J97_RS27110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J97_RS27115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J97_RS27155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4J97_RS27160	COG2267	carboxylic ester hydrolase activity
C4J97_RS27165	COG2453	phosphatase
C4J97_RS27165	COG0671	phosphoesterase, PA-phosphatase related
C4J97_RS27180	COG4589	Belongs to the CDS family
C4J97_RS27185	COG2814	Major facilitator Superfamily
C4J97_RS27200	COG0583	DNA-binding transcription factor activity
C4J97_RS27205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J97_RS27210	COG1349	DNA-binding transcription factor activity
C4J97_RS27215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J97_RS27225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4J97_RS27230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4J97_RS27235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4J97_RS27240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4J97_RS27245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J97_RS27250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4J97_RS27260	COG0356	it plays a direct role in the translocation of protons across the membrane
C4J97_RS27265	COG3312	ion transport
C4J97_RS27270	COG1475	DNA binding
C4J97_RS27275	COG1192	Involved in chromosome partitioning
C4J97_RS27280	COG0357	Ribosomal RNA small subunit methyltransferase G
C4J97_RS27285	COG0445	tRNA wobble uridine modification
C4J97_RS27290	COG1595	DNA-templated transcription, initiation
C4J97_RS27305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4J97_RS27310	COG0706	membrane insertase activity
C4J97_RS27315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4J97_RS27320	COG0594	ribonuclease P activity
C4J97_RS27325	COG0230	Belongs to the bacterial ribosomal protein bL34 family