locus-tag	class	description
H7K70_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7K70_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K70_RS00050	COG2818	Glycosylase
H7K70_RS00075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7K70_RS00080	COG0569	domain protein
H7K70_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7K70_RS00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K70_RS00095	COG0242	peptide deformylase activity
H7K70_RS00100	COG1652	LysM domain
H7K70_RS00105	COG0758	DNA mediated transformation
H7K70_RS00110	COG0009	L-threonylcarbamoyladenylate synthase
H7K70_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K70_RS00140	COG3119	arylsulfatase activity
H7K70_RS00145	COG0583	DNA-binding transcription factor activity
H7K70_RS00155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K70_RS00190	COG0159	tryptophan synthase activity
H7K70_RS00220	COG3360	Dodecin
H7K70_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K70_RS00260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7K70_RS00315	COG0659	secondary active sulfate transmembrane transporter activity
H7K70_RS00325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K70_RS00330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K70_RS00335	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7K70_RS00365	COG0109	protoheme IX farnesyltransferase activity
H7K70_RS00385	COG1629	transport
H7K70_RS00420	COG2832	Protein of unknown function (DUF454)
H7K70_RS00430	COG2011	ABC-type metal ion transport system permease component
H7K70_RS00435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7K70_RS00450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7K70_RS00460	COG0735	belongs to the Fur family
H7K70_RS00465	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7K70_RS00530	COG0415	Belongs to the DNA photolyase family
H7K70_RS00540	COG2095	MarC family integral membrane protein
H7K70_RS00545	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7K70_RS00550	COG5002	protein histidine kinase activity
H7K70_RS00555	COG2204	response regulator
H7K70_RS00585	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7K70_RS00590	COG0700	Nucleoside recognition
H7K70_RS00600	COG0612	Peptidase, M16
H7K70_RS00605	COG0840	transmembrane signaling receptor activity
H7K70_RS00620	COG0385	Bile acid
H7K70_RS00625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K70_RS00635	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7K70_RS00640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7K70_RS00645	COG1074	ATP-dependent DNA helicase activity
H7K70_RS00650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7K70_RS00655	COG1253	flavin adenine dinucleotide binding
H7K70_RS00670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7K70_RS00715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7K70_RS00720	COG0583	DNA-binding transcription factor activity
H7K70_RS00730	COG0848	biopolymer transport protein
H7K70_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K70_RS00770	COG1758	RNA polymerase activity
H7K70_RS00780	COG1561	YicC-like family, N-terminal region
H7K70_RS00785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7K70_RS00795	COG0708	Exodeoxyribonuclease III
H7K70_RS00825	COG0756	dUTP diphosphatase activity
H7K70_RS00830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7K70_RS00835	COG2003	Belongs to the UPF0758 family
H7K70_RS00845	COG0747	negative chemotaxis
H7K70_RS00850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7K70_RS00855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7K70_RS00865	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS00870	COG2814	Major facilitator Superfamily
H7K70_RS00875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS00885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS00890	COG0251	oxidation-reduction process
H7K70_RS00895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7K70_RS00910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K70_RS00930	COG0583	DNA-binding transcription factor activity
H7K70_RS00940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7K70_RS00945	COG0606	chelatase, subunit chli
H7K70_RS00955	COG0347	Belongs to the P(II) protein family
H7K70_RS00960	COG0004	ammonium transporteR
H7K70_RS00965	COG0432	Pfam Uncharacterised protein family UPF0047
H7K70_RS00975	COG0546	phosphoglycolate phosphatase activity
H7K70_RS00990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7K70_RS01010	COG1965	Belongs to the frataxin family
H7K70_RS01020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K70_RS01045	COG0625	glutathione transferase activity
H7K70_RS01055	COG3275	phosphorelay sensor kinase activity
H7K70_RS01065	COG0181	hydroxymethylbilane synthase activity
H7K70_RS01115	COG0488	(ABC) transporter
H7K70_RS01155	COG1671	Belongs to the UPF0178 family
H7K70_RS01160	COG2050	protein possibly involved in aromatic compounds catabolism
H7K70_RS01165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7K70_RS01180	COG0586	Pfam SNARE associated Golgi protein
H7K70_RS01195	COG0248	Ppx GppA phosphatase
H7K70_RS01210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7K70_RS01220	COG0583	DNA-binding transcription factor activity
H7K70_RS01230	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K70_RS01235	COG1177	transmembrane transport
H7K70_RS01270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7K70_RS01290	COG3079	Belongs to the UPF0149 family
H7K70_RS01295	COG0006	proline dipeptidase activity
H7K70_RS01300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K70_RS01310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K70_RS01320	COG1178	ABC-type Fe3 transport system permease component
H7K70_RS01360	COG1473	amidohydrolase
H7K70_RS01370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS01395	COG0523	cobalamin synthesis protein
H7K70_RS01405	COG0174	glutamine synthetase
H7K70_RS01410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7K70_RS01415	COG0174	glutamine synthetase
H7K70_RS01440	COG3842	ATPase activity
H7K70_RS01445	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K70_RS01450	COG1177	transmembrane transport
H7K70_RS01495	COG1683	Conserved Protein
H7K70_RS01510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K70_RS01515	COG0277	FAD linked oxidase domain protein
H7K70_RS01520	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K70_RS01525	COG3204	pilus organization
H7K70_RS01530	COG3111	PFAM Bacterial OB fold (BOF) protein
H7K70_RS01560	COG0531	amino acid
H7K70_RS01570	COG1177	transmembrane transport
H7K70_RS01580	COG3842	ATPase activity
H7K70_RS01590	COG3204	pilus organization
H7K70_RS01600	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7K70_RS01605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K70_RS01615	COG0702	epimerase
H7K70_RS01630	COG0494	nUDIX hydrolase
H7K70_RS01635	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H7K70_RS01650	COG0730	response to heat
H7K70_RS01655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7K70_RS01660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7K70_RS01665	COG3719	Belongs to the RNase T2 family
H7K70_RS01670	COG1160	GTP binding
H7K70_RS01680	COG0584	glycerophosphoryl diester phosphodiesterase
H7K70_RS01695	COG2233	PERMEase
H7K70_RS01705	COG0129	dihydroxy-acid dehydratase activity
H7K70_RS01720	COG0693	protein deglycase activity
H7K70_RS01735	COG0204	Acyl-transferase
H7K70_RS01755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K70_RS01765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7K70_RS01785	COG0429	hydrolase of the alpha beta-hydrolase fold
H7K70_RS01790	COG0742	ribosomal rna small subunit methyltransferase
H7K70_RS01795	COG0612	Peptidase, M16
H7K70_RS01800	COG0612	Peptidase, M16
H7K70_RS01805	COG0552	protein localization to endoplasmic reticulum
H7K70_RS01810	COG2884	Cell division ATP-binding protein ftsE
H7K70_RS01815	COG2177	Part of the ABC transporter FtsEX involved in
H7K70_RS01830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7K70_RS01835	COG2363	Small membrane protein
H7K70_RS01845	COG2022	thiamine diphosphate biosynthetic process
H7K70_RS01850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7K70_RS01865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K70_RS01870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7K70_RS01880	COG2813	Specifically methylates the guanine in position
H7K70_RS01880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K70_RS01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K70_RS01895	COG1872	DUF167
H7K70_RS01950	COG0540	Belongs to the ATCase OTCase family
H7K70_RS01955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H7K70_RS02005	COG2198	Histidine kinase
H7K70_RS02005	COG0784	Response regulator, receiver
H7K70_RS02005	COG0643	Histidine kinase
H7K70_RS02010	COG2201	protein-glutamate methylesterase activity
H7K70_RS02020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7K70_RS02035	COG3038	cytochrome b561
H7K70_RS02040	COG2353	YceI-like domain
H7K70_RS02045	COG0513	Belongs to the DEAD box helicase family
H7K70_RS02060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7K70_RS02065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7K70_RS02085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7K70_RS02095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7K70_RS02100	COG2226	methyltransferase
H7K70_RS02120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7K70_RS02125	COG0126	phosphoglycerate kinase activity
H7K70_RS02155	COG1451	nucleotide metabolic process
H7K70_RS02180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS02190	COG1289	transmembrane transporter activity
H7K70_RS02205	COG0513	Belongs to the DEAD box helicase family
H7K70_RS02210	COG0477	Major facilitator Superfamily
H7K70_RS02230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7K70_RS02255	COG4175	Glycine betaine
H7K70_RS02265	COG1760	l-serine dehydratase
H7K70_RS02285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7K70_RS02290	COG2181	nitrate reductase activity
H7K70_RS02290	COG0247	lactate metabolic process
H7K70_RS02295	COG1902	pentaerythritol trinitrate reductase activity
H7K70_RS02295	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K70_RS02320	COG3383	formate dehydrogenase (NAD+) activity
H7K70_RS02340	COG3246	L-lysine catabolic process to acetate
H7K70_RS02360	COG2205	protein histidine kinase activity
H7K70_RS02360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS02370	COG2197	response regulator
H7K70_RS02375	COG3539	Fimbrial protein
H7K70_RS02380	COG3121	Chaperone
H7K70_RS02385	COG3188	usher protein
H7K70_RS02400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K70_RS02400	COG1017	nitric oxide dioxygenase activity
H7K70_RS02450	COG1063	alcohol dehydrogenase
H7K70_RS02455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7K70_RS02460	COG0204	Acyl-transferase
H7K70_RS02475	COG0745	RESPONSE REGULATOR receiver
H7K70_RS02480	COG2205	protein histidine kinase activity
H7K70_RS02490	COG0517	IMP dehydrogenase activity
H7K70_RS02490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7K70_RS02495	COG4452	Inner membrane protein CreD
H7K70_RS02530	COG4774	siderophore transport
H7K70_RS02535	COG3712	iron ion homeostasis
H7K70_RS02540	COG1595	DNA-templated transcription, initiation
H7K70_RS02550	COG0516	GMP reductase activity
H7K70_RS02550	COG0517	IMP dehydrogenase activity
H7K70_RS02555	COG0745	RESPONSE REGULATOR receiver
H7K70_RS02560	COG1953	Uracil, thiamine, allantoin
H7K70_RS02590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7K70_RS02595	COG3585	molybdate ion transport
H7K70_RS02595	COG2005	Transcriptional regulator
H7K70_RS02610	COG0583	DNA-binding transcription factor activity
H7K70_RS02620	COG0511	ligase activity, forming carbon-carbon bonds
H7K70_RS02625	COG0439	Biotin carboxylase
H7K70_RS02635	COG1984	allophanate hydrolase subunit 2
H7K70_RS02650	COG2226	methyltransferase
H7K70_RS02650	COG1073	alpha beta
H7K70_RS02675	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS02685	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS02690	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS02695	COG0515	serine threonine protein kinase
H7K70_RS02735	COG2204	response regulator
H7K70_RS02790	COG0583	DNA-binding transcription factor activity
H7K70_RS02795	COG2258	MOSC domain
H7K70_RS02805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K70_RS02815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K70_RS02865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS02875	COG0174	glutamine synthetase
H7K70_RS02895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K70_RS02900	COG0010	Belongs to the arginase family
H7K70_RS02905	COG4670	ketone body catabolic process
H7K70_RS02910	COG2610	gluconate transmembrane transporter activity
H7K70_RS02955	COG0358	DNA primase activity
H7K70_RS02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7K70_RS02985	COG2885	chlorophyll binding
H7K70_RS02985	COG3047	cAMP biosynthetic process
H7K70_RS02990	COG2199	diguanylate cyclase activity
H7K70_RS03000	COG0617	tRNA 3'-terminal CCA addition
H7K70_RS03010	COG2719	SpoVR family
H7K70_RS03015	COG2718	Belongs to the UPF0229 family
H7K70_RS03020	COG2766	serine protein kinase
H7K70_RS03025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K70_RS03035	COG2967	ApaG domain
H7K70_RS03040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7K70_RS03050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K70_RS03055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7K70_RS03065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K70_RS03070	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7K70_RS03085	COG2197	response regulator
H7K70_RS03090	COG3842	ATPase activity
H7K70_RS03100	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K70_RS03110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7K70_RS03120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7K70_RS03125	COG0512	Glutamine amidotransferase of anthranilate synthase
H7K70_RS03145	COG1765	OsmC-like protein
H7K70_RS03155	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H7K70_RS03160	COG0537	adenosine 5'-monophosphoramidase activity
H7K70_RS03190	COG1981	membrane
H7K70_RS03205	COG0316	Belongs to the HesB IscA family
H7K70_RS03210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7K70_RS03215	COG0739	heme binding
H7K70_RS03220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7K70_RS03250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7K70_RS03250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7K70_RS03305	COG0081	regulation of translation
H7K70_RS03320	COG0085	RNA polymerase activity
H7K70_RS03325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7K70_RS03330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7K70_RS03335	COG0049	tRNA binding
H7K70_RS03340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7K70_RS03350	COG0051	transcription antitermination factor activity, RNA binding
H7K70_RS03355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7K70_RS03365	COG0089	rRNA binding
H7K70_RS03370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7K70_RS03380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7K70_RS03385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7K70_RS03395	COG0255	Belongs to the universal ribosomal protein uL29 family
H7K70_RS03400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7K70_RS03405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7K70_RS03410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7K70_RS03415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7K70_RS03420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7K70_RS03425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7K70_RS03440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7K70_RS03450	COG0200	Binds to the 23S rRNA
H7K70_RS03465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7K70_RS03475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7K70_RS03480	COG0202	RNA polymerase activity
H7K70_RS03485	COG0203	ribosomal protein L17
H7K70_RS03490	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7K70_RS03500	COG2814	Major facilitator Superfamily
H7K70_RS03525	COG3712	iron ion homeostasis
H7K70_RS03530	COG1595	DNA-templated transcription, initiation
H7K70_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS03550	COG2207	Transcriptional regulator
H7K70_RS03555	COG4999	Histidine kinase
H7K70_RS03555	COG3850	Histidine kinase
H7K70_RS03555	COG2205	protein histidine kinase activity
H7K70_RS03555	COG3437	response regulator, receiver
H7K70_RS03565	COG0804	urea catabolic process
H7K70_RS03570	COG0832	Belongs to the urease beta subunit family
H7K70_RS03585	COG0831	urea catabolic process
H7K70_RS03590	COG0829	nickel cation binding
H7K70_RS03600	COG0411	ABC transporter
H7K70_RS03615	COG0683	leucine binding
H7K70_RS03620	COG2095	MarC family integral membrane protein
H7K70_RS03655	COG2264	protein methyltransferase activity
H7K70_RS03675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K70_RS03705	COG0023	Translation Initiation Factor
H7K70_RS03710	COG1166	arginine decarboxylase activity
H7K70_RS03725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K70_RS03730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K70_RS03740	COG0534	Mate efflux family protein
H7K70_RS03745	COG2373	Large extracellular alpha-helical protein
H7K70_RS03750	COG4953	penicillin-binding protein 1C
H7K70_RS03755	COG0840	transmembrane signaling receptor activity
H7K70_RS03780	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K70_RS03780	COG1902	pentaerythritol trinitrate reductase activity
H7K70_RS03790	COG0437	4 iron, 4 sulfur cluster binding
H7K70_RS03795	COG2864	formate dehydrogenase
H7K70_RS03810	COG3276	selenocysteine insertion sequence binding
H7K70_RS03870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K70_RS03930	COG2223	nitrite transmembrane transporter activity
H7K70_RS03945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K70_RS03950	COG2824	Alkylphosphonate utilization operon protein PhnA
H7K70_RS03970	COG1295	ribonuclease BN
H7K70_RS04000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K70_RS04005	COG3047	cAMP biosynthetic process
H7K70_RS04020	COG1136	(ABC) transporter
H7K70_RS04035	COG3118	belongs to the thioredoxin family
H7K70_RS04040	COG2264	protein methyltransferase activity
H7K70_RS04055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K70_RS04055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K70_RS04070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7K70_RS04085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7K70_RS04095	COG3577	Aspartyl protease
H7K70_RS04100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7K70_RS04110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7K70_RS04115	COG4206	TonB-dependent receptor
H7K70_RS04120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7K70_RS04125	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7K70_RS04130	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS04170	COG3842	ATPase activity
H7K70_RS04180	COG0142	geranyltranstransferase activity
H7K70_RS04185	COG1722	exodeoxyribonuclease VII activity
H7K70_RS04190	COG0730	response to heat
H7K70_RS04225	COG3220	belongs to the UPF0276 family
H7K70_RS04235	COG1595	DNA-templated transcription, initiation
H7K70_RS04240	COG4944	Protein of unknown function (DUF1109)
H7K70_RS04245	COG1944	ATP diphosphatase activity
H7K70_RS04255	COG2081	HI0933 family
H7K70_RS04270	COG3228	Belongs to the MtfA family
H7K70_RS04275	COG0586	Pfam SNARE associated Golgi protein
H7K70_RS04285	COG0456	acetyltransferase
H7K70_RS04290	COG0427	acetyl-CoA hydrolase
H7K70_RS04315	COG0210	DNA helicase
H7K70_RS04325	COG0745	RESPONSE REGULATOR receiver
H7K70_RS04345	COG4303	Ethanolamine ammonia lyase large subunit
H7K70_RS04365	COG3284	Transcriptional regulator
H7K70_RS04380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K70_RS04400	COG0438	transferase activity, transferring glycosyl groups
H7K70_RS04410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7K70_RS04425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K70_RS04430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K70_RS04435	COG2226	methyltransferase
H7K70_RS04440	COG0702	epimerase
H7K70_RS04460	COG1346	cytolysis
H7K70_RS04470	COG0586	Pfam SNARE associated Golgi protein
H7K70_RS04495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7K70_RS04510	COG0768	penicillin binding
H7K70_RS04515	COG0772	Belongs to the SEDS family
H7K70_RS04520	COG2951	lytic endotransglycosylase activity
H7K70_RS04530	COG1686	Belongs to the peptidase S11 family
H7K70_RS04535	COG2921	Belongs to the UPF0250 family
H7K70_RS04540	COG0321	lipoyl(octanoyl) transferase activity
H7K70_RS04545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7K70_RS04550	COG2951	lytic endotransglycosylase activity
H7K70_RS04570	COG0495	leucyl-tRNA aminoacylation
H7K70_RS04580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7K70_RS04585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7K70_RS04590	COG4535	Mg2 and Co2 transporter CorC
H7K70_RS04595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7K70_RS04600	COG1702	phosphate starvation-inducible protein PhoH
H7K70_RS04620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7K70_RS04630	COG0351	phosphomethylpyrimidine kinase
H7K70_RS04645	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS04665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K70_RS04695	COG1522	sequence-specific DNA binding
H7K70_RS04705	COG2318	DinB family
H7K70_RS04715	COG1643	Atp-dependent helicase
H7K70_RS04725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS04750	COG1522	sequence-specific DNA binding
H7K70_RS04755	COG0697	spore germination
H7K70_RS04760	COG0513	Belongs to the DEAD box helicase family
H7K70_RS04780	COG0493	'glutamate synthase
H7K70_RS04780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K70_RS04810	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7K70_RS04820	COG1946	Acyl-CoA thioesterase
H7K70_RS04830	COG2321	neutral zinc metallopeptidase
H7K70_RS04860	COG4319	ketosteroid isomerase
H7K70_RS04865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K70_RS04875	COG0653	protein targeting
H7K70_RS04880	COG2252	PERMEase
H7K70_RS04900	COG2010	Cytochrome c
H7K70_RS04900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K70_RS04915	COG1271	oxidase subunit
H7K70_RS04920	COG1294	oxidase, subunit
H7K70_RS04955	COG3278	Belongs to the heme-copper respiratory oxidase family
H7K70_RS04965	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K70_RS04975	COG1253	flavin adenine dinucleotide binding
H7K70_RS04980	COG1970	mechanosensitive ion channel activity
H7K70_RS05025	COG1966	Carbon starvation protein
H7K70_RS05030	COG2879	small protein
H7K70_RS05035	COG0523	cobalamin synthesis protein
H7K70_RS05040	COG1595	DNA-templated transcription, initiation
H7K70_RS05050	COG4774	siderophore transport
H7K70_RS05085	COG3121	Chaperone
H7K70_RS05095	COG0488	(ABC) transporter
H7K70_RS05115	COG0430	RNA-3'-phosphate cyclase activity
H7K70_RS05135	COG3541	Predicted nucleotidyltransferase
H7K70_RS05145	COG1690	Belongs to the RtcB family
H7K70_RS05155	COG4650	regulator
H7K70_RS05160	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H7K70_RS05175	COG1067	ATP-dependent peptidase activity
H7K70_RS05185	COG2862	Uncharacterized protein family, UPF0114
H7K70_RS05190	COG0545	Peptidyl-prolyl cis-trans isomerase
H7K70_RS05200	COG0142	geranyltranstransferase activity
H7K70_RS05205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7K70_RS05220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7K70_RS05225	COG3045	CreA protein
H7K70_RS05230	COG0268	Binds directly to 16S ribosomal RNA
H7K70_RS05235	COG0728	peptidoglycan biosynthetic process
H7K70_RS05240	COG0196	riboflavin kinase activity
H7K70_RS05245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7K70_RS05255	COG1047	Peptidyl-prolyl cis-trans
H7K70_RS05260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7K70_RS05370	COG1830	Aldolase
H7K70_RS05380	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K70_RS05400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7K70_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS05410	COG2755	lipolytic protein G-D-S-L family
H7K70_RS05410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7K70_RS05425	COG2169	Transcriptional regulator
H7K70_RS05425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K70_RS05445	COG3145	DNA-N1-methyladenine dioxygenase activity
H7K70_RS05455	COG0583	DNA-binding transcription factor activity
H7K70_RS05460	COG1252	NADH dehydrogenase
H7K70_RS05500	COG0237	dephospho-CoA kinase activity
H7K70_RS05505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7K70_RS05520	COG4969	Belongs to the N-Me-Phe pilin family
H7K70_RS05525	COG3307	-O-antigen
H7K70_RS05560	COG0084	hydrolase, TatD family'
H7K70_RS05580	COG4774	siderophore transport
H7K70_RS05585	COG3128	pkhd-type hydroxylase
H7K70_RS05595	COG4774	siderophore transport
H7K70_RS05600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K70_RS05610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7K70_RS05615	COG1984	allophanate hydrolase subunit 2
H7K70_RS05620	COG4608	Belongs to the ABC transporter superfamily
H7K70_RS05625	COG0444	Belongs to the ABC transporter superfamily
H7K70_RS05630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K70_RS05635	COG0601	transmembrane transport
H7K70_RS05640	COG0747	negative chemotaxis
H7K70_RS05650	COG0747	negative chemotaxis
H7K70_RS05665	COG1247	-acetyltransferase
H7K70_RS05670	COG0747	negative chemotaxis
H7K70_RS05675	COG0747	negative chemotaxis
H7K70_RS05690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7K70_RS05700	COG4676	Protein conserved in bacteria
H7K70_RS05705	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
H7K70_RS05720	COG5445	Predicted secreted protein (DUF2300)
H7K70_RS05725	COG4676	Protein conserved in bacteria
H7K70_RS05730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K70_RS05735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K70_RS05740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7K70_RS05755	COG1077	Cell shape determining protein MreB Mrl
H7K70_RS05760	COG1792	Involved in formation and maintenance of cell shape
H7K70_RS05770	COG0424	maF-like protein
H7K70_RS05785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K70_RS05790	COG0312	modulator of DNA gyrase
H7K70_RS05800	COG0312	modulator of DNA gyrase
H7K70_RS05905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7K70_RS05990	COG4695	Portal protein
H7K70_RS06055	COG4974	Belongs to the 'phage' integrase family
H7K70_RS06065	COG1660	Displays ATPase and GTPase activities
H7K70_RS06080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K70_RS06085	COG1137	ATPase activity
H7K70_RS06090	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7K70_RS06100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7K70_RS06110	COG1127	ABC transporter
H7K70_RS06115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7K70_RS06120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K70_RS06145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7K70_RS06155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K70_RS06160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K70_RS06170	COG0175	sulfate reduction
H7K70_RS06195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7K70_RS06210	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS06220	COG0667	Aldo Keto reductase
H7K70_RS06225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7K70_RS06230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7K70_RS06235	COG0723	plastoquinol--plastocyanin reductase activity
H7K70_RS06240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7K70_RS06245	COG2857	Cytochrome c1
H7K70_RS06250	COG0625	glutathione transferase activity
H7K70_RS06255	COG2969	positive regulation of protein catabolic process
H7K70_RS06260	COG2823	Periplasmic or secreted lipoprotein
H7K70_RS06270	COG0792	nuclease activity
H7K70_RS06275	COG3107	peptidoglycan biosynthetic process
H7K70_RS06295	COG0275	rRNA processing
H7K70_RS06310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7K70_RS06315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7K70_RS06320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7K70_RS06325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7K70_RS06330	COG0772	Belongs to the SEDS family
H7K70_RS06335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7K70_RS06340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7K70_RS06345	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K70_RS06375	COG0739	heme binding
H7K70_RS06395	COG0352	thiamine-phosphate diphosphorylase activity
H7K70_RS06405	COG2096	Adenosyltransferase
H7K70_RS06420	COG0745	RESPONSE REGULATOR receiver
H7K70_RS06430	COG0668	transmembrane transport
H7K70_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS06460	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7K70_RS06465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K70_RS06470	COG0459	protein refolding
H7K70_RS06475	COG0745	RESPONSE REGULATOR receiver
H7K70_RS06480	COG0642	Histidine kinase
H7K70_RS06490	COG3642	lipopolysaccharide core region biosynthetic process
H7K70_RS06495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K70_RS06500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS06530	COG1704	LemA family
H7K70_RS06560	COG0583	DNA-binding transcription factor activity
H7K70_RS06565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K70_RS06580	COG1902	pentaerythritol trinitrate reductase activity
H7K70_RS06585	COG2814	Major facilitator Superfamily
H7K70_RS06665	COG1473	amidohydrolase
H7K70_RS06675	COG0154	amidase activity
H7K70_RS06695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7K70_RS06705	COG0693	protein deglycase activity
H7K70_RS06735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K70_RS06735	COG3153	acetyltransferase
H7K70_RS06760	COG3706	GGDEF domain
H7K70_RS06805	COG0714	Associated with various cellular activities
H7K70_RS06835	COG2925	Exonuclease
H7K70_RS06845	COG0788	formyltetrahydrofolate deformylase activity
H7K70_RS06865	COG0306	phosphate transporter
H7K70_RS06875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS06880	COG0348	domain, Protein
H7K70_RS06910	COG0494	nUDIX hydrolase
H7K70_RS06945	COG0657	acetylesterase activity
H7K70_RS06950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7K70_RS06970	COG1053	succinate dehydrogenase
H7K70_RS06975	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS07010	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS07015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K70_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS07040	COG0346	lactoylglutathione lyase activity
H7K70_RS07055	COG1024	Enoyl-CoA hydratase
H7K70_RS07065	COG1024	Enoyl-CoA hydratase
H7K70_RS07070	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS07075	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS07080	COG0183	Belongs to the thiolase family
H7K70_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS07110	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS07125	COG0183	Belongs to the thiolase family
H7K70_RS07175	COG1686	Belongs to the peptidase S11 family
H7K70_RS07230	COG1073	alpha beta
H7K70_RS07250	COG0789	Transcriptional regulator
H7K70_RS07265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7K70_RS07270	COG0563	adenylate kinase activity
H7K70_RS07275	COG1214	PFAM Peptidase M22, glycoprotease
H7K70_RS07285	COG1801	Protein of unknown function DUF72
H7K70_RS07305	COG2124	cytochrome p450
H7K70_RS07315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS07330	COG1024	Enoyl-CoA hydratase
H7K70_RS07360	COG0418	dihydroorotase activity
H7K70_RS07370	COG0137	argininosuccinate synthase activity
H7K70_RS07375	COG0346	lactoylglutathione lyase activity
H7K70_RS07385	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H7K70_RS07395	COG2937	Belongs to the GPAT DAPAT family
H7K70_RS07400	COG1131	(ABC) transporter
H7K70_RS07430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7K70_RS07435	COG4660	Part of a membrane complex involved in electron transport
H7K70_RS07440	COG4659	FMN binding
H7K70_RS07450	COG2878	Part of a membrane complex involved in electron transport
H7K70_RS07455	COG4657	Part of a membrane complex involved in electron transport
H7K70_RS07470	COG0489	protein tyrosine kinase activity
H7K70_RS07485	COG2198	Histidine kinase
H7K70_RS07485	COG0784	Response regulator, receiver
H7K70_RS07485	COG2205	protein histidine kinase activity
H7K70_RS07505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7K70_RS07510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7K70_RS07520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7K70_RS07530	COG1113	amino acid transport
H7K70_RS07555	COG1201	RNA secondary structure unwinding
H7K70_RS07560	COG1793	dna ligase
H7K70_RS07565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7K70_RS07565	COG1793	dna ligase
H7K70_RS07580	COG0625	glutathione transferase activity
H7K70_RS07585	COG0653	protein targeting
H7K70_RS07605	COG3012	SEC-C Motif Domain Protein
H7K70_RS07640	COG1199	ATP-dependent helicase activity
H7K70_RS07660	COG0259	pyridoxamine-phosphate oxidase activity
H7K70_RS07675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7K70_RS07675	COG2111	Na H antiporter
H7K70_RS07680	COG1006	Multisubunit Na H antiporter MnhC subunit
H7K70_RS07685	COG0651	ATP synthesis coupled electron transport
H7K70_RS07690	COG1863	multisubunit Na H antiporter MnhE subunit
H7K70_RS07695	COG2212	antiporter activity
H7K70_RS07700	COG1320	monovalent cation:proton antiporter activity
H7K70_RS07705	COG0697	spore germination
H7K70_RS07725	COG3189	MarR family transcriptional regulator
H7K70_RS07775	COG2084	Dehydrogenase
H7K70_RS07780	COG3622	Belongs to the hyi family
H7K70_RS07790	COG2271	Major facilitator Superfamily
H7K70_RS07795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7K70_RS07815	COG1289	transmembrane transporter activity
H7K70_RS07825	COG1566	PFAM secretion protein HlyD family protein
H7K70_RS07830	COG2030	dehydratase
H7K70_RS07835	COG2267	carboxylic ester hydrolase activity
H7K70_RS07840	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS07855	COG1643	Atp-dependent helicase
H7K70_RS07875	COG3706	GGDEF domain
H7K70_RS07880	COG0537	adenosine 5'-monophosphoramidase activity
H7K70_RS07915	COG1132	(ABC) transporter
H7K70_RS07925	COG0596	Alpha beta hydrolase
H7K70_RS07940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K70_RS07950	COG1051	belongs to the nudix hydrolase family
H7K70_RS07955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7K70_RS07960	COG0513	Belongs to the DEAD box helicase family
H7K70_RS08015	COG2996	Protein conserved in bacteria
H7K70_RS08045	COG1278	Cold shock
H7K70_RS08050	COG0242	peptide deformylase activity
H7K70_RS08070	COG0631	protein serine/threonine phosphatase activity
H7K70_RS08075	COG2815	serine threonine protein kinase
H7K70_RS08075	COG0515	serine threonine protein kinase
H7K70_RS08110	COG5265	(ABC) transporter
H7K70_RS08120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K70_RS08145	COG0217	transcriptional regulatory protein
H7K70_RS08185	COG0789	Transcriptional regulator
H7K70_RS08195	COG0583	DNA-binding transcription factor activity
H7K70_RS08200	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7K70_RS08205	COG3257	ureidoglycine aminohydrolase activity
H7K70_RS08220	COG4206	TonB-dependent receptor
H7K70_RS08230	COG0583	DNA-binding transcription factor activity
H7K70_RS08235	COG2046	Belongs to the sulfate adenylyltransferase family
H7K70_RS08245	COG2199	diguanylate cyclase activity
H7K70_RS08245	COG2203	Gaf domain
H7K70_RS08250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K70_RS08260	COG0745	RESPONSE REGULATOR receiver
H7K70_RS08265	COG2205	protein histidine kinase activity
H7K70_RS08355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K70_RS08360	COG0481	GTPase activity
H7K70_RS08375	COG0571	ribonuclease III activity
H7K70_RS08380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7K70_RS08385	COG1381	Involved in DNA repair and RecF pathway recombination
H7K70_RS08395	COG0500	methyltransferase
H7K70_RS08400	COG4106	trans-aconitate 2-methyltransferase activity
H7K70_RS08415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K70_RS08430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7K70_RS08445	COG3706	GGDEF domain
H7K70_RS08445	COG4251	negative regulation of phosphorylation
H7K70_RS08445	COG5001	Diguanylate cyclase
H7K70_RS08445	COG2203	Gaf domain
H7K70_RS08450	COG2205	protein histidine kinase activity
H7K70_RS08465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H7K70_RS08475	COG0477	Major facilitator Superfamily
H7K70_RS08480	COG2076	Multidrug Resistance protein
H7K70_RS08485	COG0385	Bile acid
H7K70_RS08490	COG2974	May be involved in recombination
H7K70_RS08505	COG0545	Peptidyl-prolyl cis-trans isomerase
H7K70_RS08560	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7K70_RS08565	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7K70_RS08580	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS08590	COG1022	Amp-dependent synthetase and ligase
H7K70_RS08595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K70_RS08615	COG3130	regulation of translation
H7K70_RS08620	COG0116	Belongs to the methyltransferase superfamily
H7K70_RS08620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7K70_RS08630	COG2027	D-alanyl-D-alanine carboxypeptidase
H7K70_RS08635	COG3171	Protein conserved in bacteria
H7K70_RS08640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7K70_RS08645	COG2197	response regulator
H7K70_RS08660	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H7K70_RS08680	COG0004	ammonium transporteR
H7K70_RS08705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K70_RS08750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7K70_RS08755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7K70_RS08760	COG0778	Nitroreductase
H7K70_RS08775	COG0745	RESPONSE REGULATOR receiver
H7K70_RS08785	COG2350	Protein conserved in bacteria
H7K70_RS08790	COG2917	probably involved in intracellular septation
H7K70_RS08800	COG0009	L-threonylcarbamoyladenylate synthase
H7K70_RS08805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7K70_RS08810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7K70_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS08835	COG0546	phosphoglycolate phosphatase activity
H7K70_RS08840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K70_RS08845	COG0402	S-adenosylhomocysteine deaminase activity
H7K70_RS08860	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7K70_RS08875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7K70_RS08880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7K70_RS08890	COG0776	regulation of translation
H7K70_RS08910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7K70_RS08935	COG0107	imidazoleglycerol-phosphate synthase activity
H7K70_RS08940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7K70_RS08945	COG1083	cytidylyl-transferase
H7K70_RS08950	COG2089	acid synthase
H7K70_RS08955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7K70_RS08965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K70_RS09010	COG0583	DNA-binding transcription factor activity
H7K70_RS09040	COG0800	Aldolase
H7K70_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS09080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7K70_RS09085	COG0066	3-isopropylmalate dehydratase activity
H7K70_RS09090	COG2226	methyltransferase
H7K70_RS09120	COG0135	phosphoribosylanthranilate isomerase activity
H7K70_RS09125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7K70_RS09130	COG0285	dihydrofolate synthase activity
H7K70_RS09140	COG1286	toxin biosynthetic process
H7K70_RS09240	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K70_RS09240	COG1902	pentaerythritol trinitrate reductase activity
H7K70_RS09260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K70_RS09270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7K70_RS09275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7K70_RS09295	COG0308	aminopeptidase N
H7K70_RS09320	COG1595	DNA-templated transcription, initiation
H7K70_RS09330	COG1629	transport
H7K70_RS09340	COG4807	Protein conserved in bacteria
H7K70_RS09355	COG1770	oligopeptidase
H7K70_RS09370	COG0121	glutamine amidotransferase
H7K70_RS09380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS09395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7K70_RS09400	COG1045	serine acetyltransferase
H7K70_RS09405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7K70_RS09410	COG4991	sh3 domain protein
H7K70_RS09430	COG0583	DNA-binding transcription factor activity
H7K70_RS09445	COG0583	DNA-binding transcription factor activity
H7K70_RS09450	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7K70_RS09455	COG0616	signal peptide processing
H7K70_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS09490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K70_RS09500	COG0024	Methionine aminopeptidase
H7K70_RS09510	COG0583	DNA-binding transcription factor activity
H7K70_RS09560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K70_RS09575	COG0431	NADPH-dependent FMN reductase
H7K70_RS09580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K70_RS09615	COG0840	transmembrane signaling receptor activity
H7K70_RS09625	COG2329	Antibiotic biosynthesis monooxygenase
H7K70_RS09630	COG0504	CTP synthase activity
H7K70_RS09640	COG0583	DNA-binding transcription factor activity
H7K70_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS09660	COG1032	radical SAM domain protein
H7K70_RS09670	COG4771	TonB-dependent receptor
H7K70_RS09700	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7K70_RS09715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K70_RS09725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K70_RS09735	COG4172	Belongs to the ABC transporter superfamily
H7K70_RS09740	COG4239	(ABC) transporter, permease
H7K70_RS09745	COG4174	ABC transporter (Permease)
H7K70_RS09750	COG4166	transmembrane transport
H7K70_RS09755	COG4166	transmembrane transport
H7K70_RS09765	COG0741	lytic transglycosylase activity
H7K70_RS09765	COG1388	LysM domain
H7K70_RS09780	COG0328	RNA-DNA hybrid ribonuclease activity
H7K70_RS09795	COG0531	amino acid
H7K70_RS09800	COG1024	Enoyl-CoA hydratase
H7K70_RS09810	COG2816	NAD+ diphosphatase activity
H7K70_RS09815	COG0730	response to heat
H7K70_RS09830	COG0477	Major facilitator Superfamily
H7K70_RS09835	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H7K70_RS09850	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7K70_RS09855	COG0784	Response regulator, receiver
H7K70_RS09855	COG0835	chemotaxis
H7K70_RS09860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7K70_RS09865	COG1815	bacterial-type flagellum-dependent cell motility
H7K70_RS09880	COG1749	Flagellar hook protein flgE
H7K70_RS09885	COG4787	bacterial-type flagellum-dependent cell motility
H7K70_RS09890	COG4786	Flagellar basal body rod
H7K70_RS09900	COG1706	bacterial-type flagellum-dependent cell motility
H7K70_RS09910	COG1256	bacterial-type flagellum assembly
H7K70_RS09920	COG1086	Polysaccharide biosynthesis protein
H7K70_RS09935	COG1083	cytidylyl-transferase
H7K70_RS09940	COG3980	spore coat polysaccharide biosynthesis protein
H7K70_RS09945	COG2089	acid synthase
H7K70_RS09950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7K70_RS09955	COG0107	imidazoleglycerol-phosphate synthase activity
H7K70_RS09965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K70_RS09980	COG0438	transferase activity, transferring glycosyl groups
H7K70_RS09980	COG1216	Glycosyl transferase, family 2
H7K70_RS10025	COG1677	Flagellar hook-basal body complex protein FliE
H7K70_RS10050	COG2882	bacterial-type flagellum organization
H7K70_RS10060	COG0745	RESPONSE REGULATOR receiver
H7K70_RS10140	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7K70_RS10145	COG0643	Histidine kinase
H7K70_RS10145	COG2198	Histidine kinase
H7K70_RS10145	COG0784	Response regulator, receiver
H7K70_RS10150	COG2201	protein-glutamate methylesterase activity
H7K70_RS10155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K70_RS10160	COG1360	Flagellar Motor Protein
H7K70_RS10165	COG1192	Involved in chromosome partitioning
H7K70_RS10175	COG0835	chemotaxis
H7K70_RS10190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K70_RS10200	COG4133	protoheme IX ABC transporter activity
H7K70_RS10220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7K70_RS10225	COG1138	Cytochrome C-type biogenesis protein
H7K70_RS10270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7K70_RS10280	COG4413	Urea transporter
H7K70_RS10285	COG0469	pyruvate kinase activity
H7K70_RS10295	COG2084	Dehydrogenase
H7K70_RS10300	COG3622	Belongs to the hyi family
H7K70_RS10305	COG3960	tartronate-semialdehyde synthase activity
H7K70_RS10320	COG1309	transcriptional regulator
H7K70_RS10325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7K70_RS10350	COG2233	PERMEase
H7K70_RS10390	COG2252	PERMEase
H7K70_RS10400	COG2186	Transcriptional regulator
H7K70_RS10420	COG3738	Protein conserved in bacteria
H7K70_RS10425	COG3011	Protein conserved in bacteria
H7K70_RS10435	COG1132	(ABC) transporter
H7K70_RS10445	COG3123	guanosine phosphorylase activity
H7K70_RS10455	COG2084	Dehydrogenase
H7K70_RS10485	COG2009	succinate dehydrogenase
H7K70_RS10490	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7K70_RS10495	COG1053	succinate dehydrogenase
H7K70_RS10500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7K70_RS10520	COG0045	succinate-CoA ligase (ADP-forming) activity
H7K70_RS10550	COG0519	Catalyzes the synthesis of GMP from XMP
H7K70_RS10555	COG0598	Magnesium transport protein CorA
H7K70_RS10645	COG2072	flavoprotein involved in K transport
H7K70_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS10660	COG0519	Catalyzes the synthesis of GMP from XMP
H7K70_RS10660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K70_RS10665	COG2308	Evidence 4 Homologs of previously reported genes of
H7K70_RS10675	COG1305	Transglutaminase-like
H7K70_RS10690	COG2194	sulfuric ester hydrolase activity
H7K70_RS10695	COG0642	Histidine kinase
H7K70_RS10720	COG1309	transcriptional regulator
H7K70_RS10745	COG2186	Transcriptional regulator
H7K70_RS10750	COG2807	transmembrane transport
H7K70_RS10755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K70_RS10765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7K70_RS10770	COG4774	siderophore transport
H7K70_RS10785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7K70_RS10790	COG1280	lysine exporter protein (LysE YggA)
H7K70_RS10810	COG0625	glutathione transferase activity
H7K70_RS10820	COG0628	permease
H7K70_RS10825	COG5339	Protein conserved in bacteria
H7K70_RS10855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7K70_RS10860	COG0492	ferredoxin-NADP+ reductase activity
H7K70_RS10895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K70_RS10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K70_RS10935	COG0348	domain, Protein
H7K70_RS10940	COG2010	Cytochrome c
H7K70_RS10955	COG3278	Belongs to the heme-copper respiratory oxidase family
H7K70_RS10975	COG3278	Belongs to the heme-copper respiratory oxidase family
H7K70_RS10985	COG1522	sequence-specific DNA binding
H7K70_RS10990	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H7K70_RS11005	COG1113	amino acid transport
H7K70_RS11020	COG3284	Transcriptional regulator
H7K70_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS11030	COG3199	ATP-NAD kinase
H7K70_RS11035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7K70_RS11040	COG0022	dehydrogenase e1 component
H7K70_RS11050	COG1063	alcohol dehydrogenase
H7K70_RS11090	COG4221	oxidoreductase activity
H7K70_RS11100	COG2199	diguanylate cyclase activity
H7K70_RS11100	COG2203	Gaf domain
H7K70_RS11110	COG1397	ADP-ribosylglycohydrolase
H7K70_RS11120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K70_RS11120	COG1017	nitric oxide dioxygenase activity
H7K70_RS11125	COG0625	glutathione transferase activity
H7K70_RS11135	COG0583	DNA-binding transcription factor activity
H7K70_RS11165	COG0840	transmembrane signaling receptor activity
H7K70_RS11180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7K70_RS11200	COG4251	negative regulation of phosphorylation
H7K70_RS11200	COG3706	GGDEF domain
H7K70_RS11200	COG2203	Gaf domain
H7K70_RS11200	COG5001	Diguanylate cyclase
H7K70_RS11205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7K70_RS11220	COG1538	Outer membrane efflux protein
H7K70_RS11225	COG2274	protein secretion by the type I secretion system
H7K70_RS11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS11235	COG0590	tRNA wobble adenosine to inosine editing
H7K70_RS11250	COG0477	Major facilitator Superfamily
H7K70_RS11285	COG2207	Transcriptional regulator
H7K70_RS11310	COG0439	Biotin carboxylase
H7K70_RS11320	COG3665	Urea carboxylase-associated protein
H7K70_RS11325	COG1116	anion transmembrane transporter activity
H7K70_RS11365	COG2207	Transcriptional regulator
H7K70_RS11365	COG1917	Cupin 2, conserved barrel domain protein
H7K70_RS11375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K70_RS11380	COG0583	DNA-binding transcription factor activity
H7K70_RS11385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7K70_RS11390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7K70_RS11400	COG2031	fatty acid transporter
H7K70_RS11425	COG0784	Response regulator, receiver
H7K70_RS11425	COG4191	Histidine kinase
H7K70_RS11450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K70_RS11455	COG0784	Response regulator, receiver
H7K70_RS11455	COG2205	protein histidine kinase activity
H7K70_RS11455	COG5002	protein histidine kinase activity
H7K70_RS11460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7K70_RS11485	COG1022	Amp-dependent synthetase and ligase
H7K70_RS11495	COG0708	Exodeoxyribonuclease III
H7K70_RS11505	COG0729	surface antigen
H7K70_RS11510	COG2911	Protein conserved in bacteria
H7K70_RS11610	COG4397	Mu-like prophage major head subunit gpT
H7K70_RS11640	COG4383	Mu-like prophage protein gp29
H7K70_RS11645	COG4373	Mu-like prophage FluMu protein gp28
H7K70_RS11655	COG0640	Transcriptional regulator
H7K70_RS11740	COG3409	Peptidoglycan-binding domain 1 protein
H7K70_RS11740	COG3267	Type II secretory pathway component ExeA
H7K70_RS11770	COG4382	Mu-like prophage protein Gp16
H7K70_RS11775	COG5566	PFAM Mor transcription activator
H7K70_RS11780	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7K70_RS11800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K70_RS11820	COG0583	DNA-binding transcription factor activity
H7K70_RS11855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K70_RS11865	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7K70_RS11875	COG0583	DNA-binding transcription factor activity
H7K70_RS11895	COG1464	Belongs to the NlpA lipoprotein family
H7K70_RS11905	COG2011	ABC-type metal ion transport system permease component
H7K70_RS11910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K70_RS11915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K70_RS11920	COG1116	anion transmembrane transporter activity
H7K70_RS11935	COG0784	Response regulator, receiver
H7K70_RS11935	COG2205	protein histidine kinase activity
H7K70_RS11935	COG5002	protein histidine kinase activity
H7K70_RS11960	COG2153	protein acetylation
H7K70_RS11965	COG2850	peptidyl-arginine hydroxylation
H7K70_RS11975	COG2915	High frequency lysogenization protein hflD homolog
H7K70_RS11980	COG0482	sulfurtransferase activity
H7K70_RS12000	COG1278	Cold shock
H7K70_RS12005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7K70_RS12010	COG0542	response to heat
H7K70_RS12015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7K70_RS12020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7K70_RS12025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7K70_RS12030	COG0492	ferredoxin-NADP+ reductase activity
H7K70_RS12040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7K70_RS12045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7K70_RS12050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7K70_RS12065	COG0435	Glutathione S-transferase
H7K70_RS12070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K70_RS12075	COG2920	part of a sulfur-relay system
H7K70_RS12180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7K70_RS12270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K70_RS12290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K70_RS12300	COG5001	Diguanylate cyclase
H7K70_RS12300	COG3300	MHYT domain
H7K70_RS12310	COG2706	6-phosphogluconolactonase activity
H7K70_RS12345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7K70_RS12350	COG0835	chemotaxis
H7K70_RS12355	COG0840	transmembrane signaling receptor activity
H7K70_RS12360	COG2198	Histidine kinase
H7K70_RS12360	COG0643	Histidine kinase
H7K70_RS12370	COG0745	RESPONSE REGULATOR receiver
H7K70_RS12380	COG1653	transport
H7K70_RS12385	COG1175	transmembrane transport
H7K70_RS12390	COG0395	ABC-type sugar transport system, permease component
H7K70_RS12395	COG3842	ATPase activity
H7K70_RS12400	COG4580	involved in the transport of maltose and maltodextrins
H7K70_RS12405	COG0676	glucose-6-phosphate 1-epimerase activity
H7K70_RS12410	COG1737	Transcriptional regulator
H7K70_RS12425	COG0800	Aldolase
H7K70_RS12440	COG1609	Transcriptional regulator
H7K70_RS12450	COG1105	Belongs to the carbohydrate kinase PfkB family
H7K70_RS12455	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7K70_RS12455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K70_RS12455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K70_RS12460	COG0583	DNA-binding transcription factor activity
H7K70_RS12480	COG1566	PFAM secretion protein HlyD family protein
H7K70_RS12485	COG3089	Belongs to the UPF0270 family
H7K70_RS12490	COG5002	protein histidine kinase activity
H7K70_RS12490	COG2205	protein histidine kinase activity
H7K70_RS12490	COG0784	Response regulator, receiver
H7K70_RS12495	COG1363	Peptidase, m42
H7K70_RS12505	COG0367	asparagine synthase
H7K70_RS12510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7K70_RS12510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS12520	COG1024	Enoyl-CoA hydratase
H7K70_RS12525	COG1024	Enoyl-CoA hydratase
H7K70_RS12530	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS12550	COG2720	vancomycin resistance protein
H7K70_RS12555	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7K70_RS12575	COG0271	Belongs to the BolA IbaG family
H7K70_RS12580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K70_RS12595	COG0543	2 iron, 2 sulfur cluster binding
H7K70_RS12595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K70_RS12600	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H7K70_RS12605	COG4638	Rieske (2fe-2S)
H7K70_RS12620	COG0604	alcohol dehydrogenase
H7K70_RS12625	COG1309	transcriptional regulator
H7K70_RS12665	COG1611	Belongs to the LOG family
H7K70_RS12675	COG0417	DNA replication proofreading
H7K70_RS12695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS12695	COG2205	protein histidine kinase activity
H7K70_RS12715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7K70_RS12720	COG2030	dehydratase
H7K70_RS12720	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS12735	COG3162	membrane
H7K70_RS12740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K70_RS12745	COG2151	metal-sulfur cluster biosynthetic enzyme
H7K70_RS12750	COG3396	Phenylacetate-CoA oxygenase
H7K70_RS12755	COG3460	Phenylacetate-CoA oxygenase
H7K70_RS12760	COG3396	Phenylacetate-CoA oxygenase
H7K70_RS12855	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7K70_RS12875	COG0183	Belongs to the thiolase family
H7K70_RS12880	COG2050	protein possibly involved in aromatic compounds catabolism
H7K70_RS12885	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS12890	COG1024	Enoyl-CoA hydratase
H7K70_RS12895	COG1024	Enoyl-CoA hydratase
H7K70_RS12905	COG3327	negative regulation of DNA-templated transcription, initiation
H7K70_RS12935	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS12950	COG0583	DNA-binding transcription factor activity
H7K70_RS12955	COG4191	Histidine kinase
H7K70_RS12955	COG0784	Response regulator, receiver
H7K70_RS12985	COG2831	hemolysin activation secretion protein
H7K70_RS13000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7K70_RS13005	COG2318	DinB family
H7K70_RS13015	COG2378	regulation of single-species biofilm formation
H7K70_RS13025	COG0786	glutamate:sodium symporter activity
H7K70_RS13030	COG1335	isochorismatase
H7K70_RS13035	COG1764	response to oxidative stress
H7K70_RS13050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7K70_RS13055	COG0626	cystathionine gamma-synthase activity
H7K70_RS13060	COG0833	amino acid
H7K70_RS13065	COG0583	DNA-binding transcription factor activity
H7K70_RS13075	COG1522	sequence-specific DNA binding
H7K70_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS13100	COG2207	Transcriptional regulator
H7K70_RS13100	COG1917	Cupin 2, conserved barrel domain protein
H7K70_RS13105	COG1335	isochorismatase
H7K70_RS13110	COG4566	intracellular signal transduction
H7K70_RS13115	COG0745	RESPONSE REGULATOR receiver
H7K70_RS13115	COG4566	intracellular signal transduction
H7K70_RS13130	COG0583	DNA-binding transcription factor activity
H7K70_RS13135	COG2828	Protein conserved in bacteria
H7K70_RS13140	COG2851	Citrate transporter
H7K70_RS13150	COG0861	Integral membrane protein TerC family
H7K70_RS13160	COG4251	negative regulation of phosphorylation
H7K70_RS13160	COG5001	Diguanylate cyclase
H7K70_RS13160	COG3706	GGDEF domain
H7K70_RS13160	COG2203	Gaf domain
H7K70_RS13170	COG4106	trans-aconitate 2-methyltransferase activity
H7K70_RS13210	COG1696	Membrane protein involved in D-alanine export
H7K70_RS13230	COG1215	transferase activity, transferring glycosyl groups
H7K70_RS13335	COG0531	amino acid
H7K70_RS13340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7K70_RS13345	COG3938	Belongs to the proline racemase family
H7K70_RS13350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K70_RS13370	COG3729	General stress protein
H7K70_RS13390	COG1285	pathogenesis
H7K70_RS13410	COG0789	Transcriptional regulator
H7K70_RS13425	COG0765	amino acid transport
H7K70_RS13430	COG0765	amino acid transport
H7K70_RS13435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS13445	COG0583	DNA-binding transcription factor activity
H7K70_RS13455	COG0659	secondary active sulfate transmembrane transporter activity
H7K70_RS13465	COG4948	Mandelate Racemase Muconate Lactonizing
H7K70_RS13470	COG4829	muconolactone delta-isomerase
H7K70_RS13475	COG3485	protocatechuate 3,4-dioxygenase
H7K70_RS13515	COG0642	Histidine kinase
H7K70_RS13560	COG0826	peptidase U32
H7K70_RS13570	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H7K70_RS13585	COG3483	tryptophan 2,3-dioxygenase activity
H7K70_RS13605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K70_RS13625	COG1132	(ABC) transporter
H7K70_RS13630	COG1132	(ABC) transporter
H7K70_RS13635	COG4771	TonB-dependent receptor
H7K70_RS13655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS13725	COG3397	chitin binding
H7K70_RS13750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K70_RS13765	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS13790	COG0583	DNA-binding transcription factor activity
H7K70_RS13820	COG3842	ATPase activity
H7K70_RS13825	COG1178	ABC-type Fe3 transport system permease component
H7K70_RS13830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K70_RS13835	COG1840	ABC-type Fe3 transport system, periplasmic component
H7K70_RS13850	COG0842	Transport permease protein
H7K70_RS13855	COG1131	(ABC) transporter
H7K70_RS13860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS13870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K70_RS13905	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7K70_RS13915	COG0392	lysyltransferase activity
H7K70_RS13920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7K70_RS13925	COG3568	Endonuclease Exonuclease Phosphatase
H7K70_RS13995	COG1053	succinate dehydrogenase
H7K70_RS14000	COG2233	PERMEase
H7K70_RS14010	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7K70_RS14015	COG0709	Synthesizes selenophosphate from selenide and ATP
H7K70_RS14020	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H7K70_RS14025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H7K70_RS14030	COG3639	organic phosphonate transmembrane transporter activity
H7K70_RS14080	COG3729	General stress protein
H7K70_RS14090	COG1063	alcohol dehydrogenase
H7K70_RS14100	COG3685	Protein conserved in bacteria
H7K70_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS14125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K70_RS14130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS14210	COG3424	synthase
H7K70_RS14260	COG0681	Belongs to the peptidase S26 family
H7K70_RS14270	COG4285	Biotin-protein ligase, N terminal
H7K70_RS14275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K70_RS14280	COG3154	lipid carrier protein
H7K70_RS14285	COG0826	peptidase U32
H7K70_RS14290	COG0826	peptidase U32
H7K70_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS14315	COG0765	amino acid transport
H7K70_RS14335	COG0667	Aldo Keto reductase
H7K70_RS14340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7K70_RS14355	COG0084	hydrolase, TatD family'
H7K70_RS14405	COG5001	Diguanylate cyclase
H7K70_RS14405	COG4251	negative regulation of phosphorylation
H7K70_RS14405	COG3706	GGDEF domain
H7K70_RS14405	COG2203	Gaf domain
H7K70_RS14415	COG0596	Alpha beta hydrolase
H7K70_RS14425	COG3655	Transcriptional regulator
H7K70_RS14435	COG0583	DNA-binding transcription factor activity
H7K70_RS14440	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS14445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K70_RS14450	COG3842	ATPase activity
H7K70_RS14455	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K70_RS14460	COG1177	transmembrane transport
H7K70_RS14465	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS14475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7K70_RS14480	COG3300	MHYT domain
H7K70_RS14480	COG5001	Diguanylate cyclase
H7K70_RS14490	COG0626	cystathionine gamma-synthase activity
H7K70_RS14510	COG1546	Belongs to the CinA family
H7K70_RS14510	COG1058	Belongs to the CinA family
H7K70_RS14515	COG0297	glycogen (starch) synthase activity
H7K70_RS14520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7K70_RS14565	COG3706	GGDEF domain
H7K70_RS14565	COG4251	negative regulation of phosphorylation
H7K70_RS14565	COG2203	Gaf domain
H7K70_RS14565	COG5001	Diguanylate cyclase
H7K70_RS14570	COG0583	DNA-binding transcription factor activity
H7K70_RS14580	COG4771	TonB-dependent receptor
H7K70_RS14590	COG1858	cytochrome C peroxidase
H7K70_RS14630	COG3546	catalase activity
H7K70_RS14660	COG3245	cytochrome
H7K70_RS14715	COG1716	ATPase activity
H7K70_RS14715	COG5001	Diguanylate cyclase
H7K70_RS14730	COG2197	response regulator
H7K70_RS14735	COG2205	protein histidine kinase activity
H7K70_RS14735	COG2198	Histidine kinase
H7K70_RS14735	COG0784	Response regulator, receiver
H7K70_RS14750	COG4774	siderophore transport
H7K70_RS14775	COG2957	Belongs to the agmatine deiminase family
H7K70_RS14780	COG0583	DNA-binding transcription factor activity
H7K70_RS14800	COG3119	arylsulfatase activity
H7K70_RS14805	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS14810	COG0183	Belongs to the thiolase family
H7K70_RS14820	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS14825	COG1024	Enoyl-CoA hydratase
H7K70_RS14830	COG2814	Major facilitator Superfamily
H7K70_RS14865	COG1309	transcriptional regulator
H7K70_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS14895	COG0583	DNA-binding transcription factor activity
H7K70_RS14905	COG0596	Alpha beta hydrolase
H7K70_RS14910	COG4585	Histidine kinase
H7K70_RS14915	COG2197	response regulator
H7K70_RS14935	COG2198	Histidine kinase
H7K70_RS14935	COG0643	Histidine kinase
H7K70_RS14945	COG0840	transmembrane signaling receptor activity
H7K70_RS14950	COG0835	chemotaxis
H7K70_RS14960	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7K70_RS15025	COG0577	efflux transmembrane transporter activity
H7K70_RS15025	COG1136	(ABC) transporter
H7K70_RS15030	COG0577	efflux transmembrane transporter activity
H7K70_RS15030	COG1136	(ABC) transporter
H7K70_RS15065	COG2815	serine threonine protein kinase
H7K70_RS15065	COG0515	serine threonine protein kinase
H7K70_RS15165	COG0346	lactoylglutathione lyase activity
H7K70_RS15215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K70_RS15260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K70_RS15265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K70_RS15270	COG1309	transcriptional regulator
H7K70_RS15275	COG1082	Xylose isomerase domain protein TIM barrel
H7K70_RS15275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H7K70_RS15280	COG0477	Major facilitator Superfamily
H7K70_RS15290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K70_RS15320	COG0811	peptide transport
H7K70_RS15350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K70_RS15355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K70_RS15365	COG0183	Belongs to the thiolase family
H7K70_RS15370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7K70_RS15375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7K70_RS15505	COG4373	Mu-like prophage FluMu protein gp28
H7K70_RS15510	COG4383	Mu-like prophage protein gp29
H7K70_RS15515	COG2369	cell adhesion
H7K70_RS15530	COG4397	Mu-like prophage major head subunit gpT
H7K70_RS15635	COG0657	acetylesterase activity
H7K70_RS15675	COG0840	transmembrane signaling receptor activity
H7K70_RS15690	COG2116	formate transmembrane transporter activity
H7K70_RS15705	COG4771	TonB-dependent receptor
H7K70_RS15710	COG3300	MHYT domain
H7K70_RS15710	COG5001	Diguanylate cyclase
H7K70_RS15715	COG2204	response regulator
H7K70_RS15735	COG5002	protein histidine kinase activity
H7K70_RS15745	COG0745	RESPONSE REGULATOR receiver
H7K70_RS15775	COG1368	sulfuric ester hydrolase activity
H7K70_RS15785	COG2239	Acts as a magnesium transporter
H7K70_RS15800	COG0477	Major facilitator Superfamily
H7K70_RS15810	COG0667	Aldo Keto reductase
H7K70_RS15825	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS15830	COG2223	nitrite transmembrane transporter activity
H7K70_RS15835	COG4948	Mandelate Racemase Muconate Lactonizing
H7K70_RS15840	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7K70_RS15850	COG0583	DNA-binding transcription factor activity
H7K70_RS15900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS15910	COG1538	Outer membrane efflux protein
H7K70_RS15920	COG1414	Transcriptional regulator
H7K70_RS15925	COG0679	Auxin Efflux Carrier
H7K70_RS15930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7K70_RS15935	COG3485	protocatechuate 3,4-dioxygenase
H7K70_RS15940	COG3485	protocatechuate 3,4-dioxygenase
H7K70_RS15945	COG0583	DNA-binding transcription factor activity
H7K70_RS15960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K70_RS15970	COG2814	Major facilitator Superfamily
H7K70_RS15975	COG0583	DNA-binding transcription factor activity
H7K70_RS15995	COG4251	negative regulation of phosphorylation
H7K70_RS15995	COG3706	GGDEF domain
H7K70_RS15995	COG5001	Diguanylate cyclase
H7K70_RS15995	COG2203	Gaf domain
H7K70_RS16000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K70_RS16005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K70_RS16010	COG1116	anion transmembrane transporter activity
H7K70_RS16025	COG1917	Cupin 2, conserved barrel domain protein
H7K70_RS16025	COG4977	sequence-specific DNA binding
H7K70_RS16035	COG0058	SHG alpha-glucan phosphorylase activity
H7K70_RS16060	COG3281	Trehalose synthase
H7K70_RS16080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K70_RS16080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K70_RS16085	COG1760	l-serine dehydratase
H7K70_RS16090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7K70_RS16105	COG4191	Histidine kinase
H7K70_RS16105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS16110	COG3437	response regulator, receiver
H7K70_RS16110	COG0784	Response regulator, receiver
H7K70_RS16115	COG4178	(ABC) transporter
H7K70_RS16170	COG1132	(ABC) transporter
H7K70_RS16175	COG3284	Transcriptional regulator
H7K70_RS16185	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS16190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K70_RS16195	COG1024	Enoyl-CoA hydratase
H7K70_RS16195	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS16230	COG0789	Transcriptional regulator
H7K70_RS16235	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS16245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K70_RS16255	COG0842	Transport permease protein
H7K70_RS16260	COG1131	(ABC) transporter
H7K70_RS16265	COG0625	glutathione transferase activity
H7K70_RS16325	COG1956	GAF domain-containing protein
H7K70_RS16335	COG0784	Response regulator, receiver
H7K70_RS16335	COG2205	protein histidine kinase activity
H7K70_RS16335	COG5002	protein histidine kinase activity
H7K70_RS16340	COG1846	Transcriptional regulator
H7K70_RS16345	COG0386	Belongs to the glutathione peroxidase family
H7K70_RS16350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K70_RS16355	COG0436	Aminotransferase
H7K70_RS16360	COG0300	oxidoreductase activity
H7K70_RS16370	COG0501	Belongs to the peptidase M48B family
H7K70_RS16375	COG0500	methyltransferase
H7K70_RS16380	COG3384	dioxygenase
H7K70_RS16385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7K70_RS16395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K70_RS16420	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H7K70_RS16425	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7K70_RS16430	COG0235	Class ii aldolase
H7K70_RS16440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7K70_RS16460	COG1335	isochorismatase
H7K70_RS16470	COG2840	Smr protein MutS2
H7K70_RS16495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS16515	COG3135	benzoate transporter
H7K70_RS16525	COG2130	NADP-dependent
H7K70_RS16530	COG3214	Protein conserved in bacteria
H7K70_RS16550	COG0583	DNA-binding transcription factor activity
H7K70_RS16560	COG0583	DNA-binding transcription factor activity
H7K70_RS16570	COG1846	Transcriptional regulator
H7K70_RS16610	COG0069	glutamate synthase activity
H7K70_RS16615	COG0583	DNA-binding transcription factor activity
H7K70_RS16655	COG3766	membrane
H7K70_RS16665	COG0754	glutathionylspermidine amidase activity
H7K70_RS16685	COG3046	protein related to deoxyribodipyrimidine photolyase
H7K70_RS16720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K70_RS16730	COG1677	Flagellar hook-basal body complex protein FliE
H7K70_RS16755	COG1987	bacterial-type flagellum assembly
H7K70_RS16765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K70_RS16775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K70_RS16795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K70_RS16800	COG1191	sigma factor activity
H7K70_RS16825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7K70_RS16845	COG0741	lytic transglycosylase activity
H7K70_RS16850	COG1706	bacterial-type flagellum-dependent cell motility
H7K70_RS16860	COG4786	Flagellar basal body rod
H7K70_RS16865	COG4787	bacterial-type flagellum-dependent cell motility
H7K70_RS16870	COG4786	Flagellar basal body rod
H7K70_RS16875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7K70_RS16880	COG1558	bacterial-type flagellum-dependent cell motility
H7K70_RS16895	COG3300	MHYT domain
H7K70_RS16895	COG5001	Diguanylate cyclase
H7K70_RS16905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K70_RS16910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7K70_RS16930	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7K70_RS16935	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K70_RS16975	COG0564	pseudouridine synthase activity
H7K70_RS16985	COG2010	Cytochrome c
H7K70_RS16990	COG0753	catalase activity
H7K70_RS17010	COG0662	Cupin 2, conserved barrel domain protein
H7K70_RS17020	COG2866	Carboxypeptidase
H7K70_RS17035	COG0842	Transport permease protein
H7K70_RS17040	COG1129	ABC transporter
H7K70_RS17040	COG0842	Transport permease protein
H7K70_RS17045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS17080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K70_RS17085	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K70_RS17110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7K70_RS17115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K70_RS17125	COG0713	ATP synthesis coupled electron transport
H7K70_RS17140	COG1007	ATP synthesis coupled electron transport
H7K70_RS17160	COG2056	Na+-H+ antiporter family
H7K70_RS17165	COG0840	transmembrane signaling receptor activity
H7K70_RS17170	COG0431	NADPH-dependent FMN reductase
H7K70_RS17185	COG0753	catalase activity
H7K70_RS17210	COG5006	permease, DMT superfamily
H7K70_RS17215	COG1045	serine acetyltransferase
H7K70_RS17220	COG2199	diguanylate cyclase activity
H7K70_RS17235	COG0587	DNA-directed DNA polymerase activity
H7K70_RS17290	COG2135	peptidase activity
H7K70_RS17305	COG3179	chitinase
H7K70_RS17560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7K70_RS17570	COG0745	RESPONSE REGULATOR receiver
H7K70_RS17580	COG2853	Lipoprotein
H7K70_RS17600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7K70_RS17600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7K70_RS17610	COG2132	Multicopper oxidase
H7K70_RS17635	COG1538	Outer membrane efflux protein
H7K70_RS17640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K70_RS17680	COG1741	Belongs to the pirin family
H7K70_RS17700	COG0583	DNA-binding transcription factor activity
H7K70_RS17705	COG1940	carbohydrate kinase activity
H7K70_RS17715	COG3971	2-oxopent-4-enoate hydratase activity
H7K70_RS17720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K70_RS17745	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS17750	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS17755	COG0028	Belongs to the TPP enzyme family
H7K70_RS17770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K70_RS17785	COG2207	Transcriptional regulator
H7K70_RS17820	COG0326	Molecular chaperone. Has ATPase activity
H7K70_RS17860	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS17860	COG1024	Enoyl-CoA hydratase
H7K70_RS17865	COG0183	Belongs to the thiolase family
H7K70_RS17870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K70_RS17900	COG2267	carboxylic ester hydrolase activity
H7K70_RS17905	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS17915	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS17920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K70_RS17925	COG2186	Transcriptional regulator
H7K70_RS17940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7K70_RS17950	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K70_RS17960	COG3842	ATPase activity
H7K70_RS17970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS17975	COG0765	amino acid transport
H7K70_RS17980	COG0765	amino acid transport
H7K70_RS17985	COG1126	abc transporter atp-binding protein
H7K70_RS18020	COG0583	DNA-binding transcription factor activity
H7K70_RS18055	COG3245	cytochrome
H7K70_RS18090	COG3530	Putative quorum-sensing-regulated virulence factor
H7K70_RS18095	COG0506	proline dehydrogenase activity
H7K70_RS18095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7K70_RS18095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7K70_RS18100	COG0840	transmembrane signaling receptor activity
H7K70_RS18105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K70_RS18110	COG0583	DNA-binding transcription factor activity
H7K70_RS18115	COG2814	Major facilitator Superfamily
H7K70_RS18145	COG4999	Histidine kinase
H7K70_RS18145	COG3850	Histidine kinase
H7K70_RS18145	COG3437	response regulator, receiver
H7K70_RS18145	COG2205	protein histidine kinase activity
H7K70_RS18150	COG2274	protein secretion by the type I secretion system
H7K70_RS18205	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS18215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K70_RS18230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7K70_RS18235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7K70_RS18255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7K70_RS18260	COG3115	cell septum assembly
H7K70_RS18285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K70_RS18300	COG0402	S-adenosylhomocysteine deaminase activity
H7K70_RS18310	COG1024	Enoyl-CoA hydratase
H7K70_RS18310	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS18335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K70_RS18350	COG0463	Glycosyl transferase, family 2
H7K70_RS18365	COG3712	iron ion homeostasis
H7K70_RS18370	COG1595	DNA-templated transcription, initiation
H7K70_RS18385	COG0583	DNA-binding transcription factor activity
H7K70_RS18395	COG0488	(ABC) transporter
H7K70_RS18400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K70_RS18430	COG2267	carboxylic ester hydrolase activity
H7K70_RS18435	COG1968	undecaprenyl-diphosphatase activity
H7K70_RS18440	COG0840	transmembrane signaling receptor activity
H7K70_RS18510	COG3604	Transcriptional regulator
H7K70_RS18515	COG0720	synthase
H7K70_RS18550	COG4566	intracellular signal transduction
H7K70_RS18555	COG4191	Histidine kinase
H7K70_RS18565	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS18570	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS18585	COG4977	sequence-specific DNA binding
H7K70_RS18585	COG1917	Cupin 2, conserved barrel domain protein
H7K70_RS18600	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS18650	COG0072	phenylalanine-tRNA ligase activity
H7K70_RS18655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7K70_RS18660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7K70_RS18665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7K70_RS18670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7K70_RS18675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7K70_RS18690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS18710	COG3813	Protein conserved in bacteria
H7K70_RS18730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7K70_RS18730	COG0316	Belongs to the HesB IscA family
H7K70_RS18785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7K70_RS18795	COG1879	ABC-type sugar transport system periplasmic component
H7K70_RS18805	COG0714	Associated with various cellular activities
H7K70_RS18815	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H7K70_RS18835	COG0215	cysteine-tRNA ligase activity
H7K70_RS18845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7K70_RS18865	COG0589	response to stress
H7K70_RS18895	COG0436	Aminotransferase
H7K70_RS18925	COG0668	transmembrane transport
H7K70_RS18940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K70_RS18955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7K70_RS18960	COG1280	lysine exporter protein (LysE YggA)
H7K70_RS18985	COG1802	Transcriptional regulator
H7K70_RS18990	COG4067	protein conserved in archaea
H7K70_RS18990	COG0189	ligase activity
H7K70_RS19030	COG2909	trisaccharide binding
H7K70_RS19035	COG2909	trisaccharide binding
H7K70_RS19065	COG0589	response to stress
H7K70_RS19075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K70_RS19110	COG1376	ErfK ybiS ycfS ynhG family protein
H7K70_RS19125	COG4181	ATPase activity
H7K70_RS19130	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7K70_RS19170	COG2259	Doxx family
H7K70_RS19175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K70_RS19180	COG0084	hydrolase, TatD family'
H7K70_RS19225	COG0714	Associated with various cellular activities
H7K70_RS19235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K70_RS19265	COG0745	RESPONSE REGULATOR receiver
H7K70_RS19270	COG2205	protein histidine kinase activity
H7K70_RS19300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7K70_RS19310	COG0542	response to heat
H7K70_RS19360	COG1280	lysine exporter protein (LysE YggA)
H7K70_RS19390	COG1309	transcriptional regulator
H7K70_RS19405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K70_RS19410	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS19415	COG1024	Enoyl-CoA hydratase
H7K70_RS19425	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS19440	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS19465	COG1595	DNA-templated transcription, initiation
H7K70_RS19470	COG2304	oxidoreductase activity
H7K70_RS19480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7K70_RS19485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7K70_RS19490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7K70_RS19495	COG2835	tetraacyldisaccharide 4'-kinase activity
H7K70_RS19500	COG1663	tetraacyldisaccharide 4'-kinase activity
H7K70_RS19505	COG0848	biopolymer transport protein
H7K70_RS19510	COG0811	peptide transport
H7K70_RS19515	COG2333	competence protein COMEC
H7K70_RS19515	COG0658	competence protein
H7K70_RS19525	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7K70_RS19535	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7K70_RS19550	COG0584	glycerophosphoryl diester phosphodiesterase
H7K70_RS19555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K70_RS19565	COG1477	protein flavinylation
H7K70_RS19590	COG1805	sodium ion transport
H7K70_RS19600	COG1113	amino acid transport
H7K70_RS19610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7K70_RS19620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7K70_RS19645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7K70_RS19675	COG0183	Belongs to the thiolase family
H7K70_RS19680	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS19680	COG1024	Enoyl-CoA hydratase
H7K70_RS19695	COG0589	response to stress
H7K70_RS19705	COG0488	(ABC) transporter
H7K70_RS19710	COG0741	lytic transglycosylase activity
H7K70_RS19735	COG1070	Carbohydrate kinase
H7K70_RS19740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7K70_RS19745	COG0277	FAD linked oxidase domain protein
H7K70_RS19745	COG0277	FAD linked oxidase domain protein
H7K70_RS19755	COG0303	'Molybdopterin
H7K70_RS19760	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7K70_RS19765	COG0746	molybdenum cofactor guanylyltransferase activity
H7K70_RS19785	COG2205	protein histidine kinase activity
H7K70_RS19785	COG2198	Histidine kinase
H7K70_RS19785	COG0784	Response regulator, receiver
H7K70_RS19820	COG0535	radical SAM domain protein
H7K70_RS19830	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
H7K70_RS19835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7K70_RS19870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7K70_RS19875	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS19885	COG2814	Major facilitator Superfamily
H7K70_RS19900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7K70_RS19910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K70_RS19920	COG1846	Transcriptional regulator
H7K70_RS19925	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7K70_RS19935	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS19940	COG3384	dioxygenase
H7K70_RS19950	COG2271	Major facilitator Superfamily
H7K70_RS19955	COG3971	2-oxopent-4-enoate hydratase activity
H7K70_RS19970	COG0297	glycogen (starch) synthase activity
H7K70_RS19980	COG2207	Transcriptional regulator
H7K70_RS19985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K70_RS19985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K70_RS20005	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7K70_RS20015	COG2814	Major facilitator Superfamily
H7K70_RS20030	COG5001	Diguanylate cyclase
H7K70_RS20030	COG4251	negative regulation of phosphorylation
H7K70_RS20030	COG3706	GGDEF domain
H7K70_RS20030	COG2203	Gaf domain
H7K70_RS20035	COG0514	ATP-dependent DNA helicase (RecQ)
H7K70_RS20045	COG2832	Protein of unknown function (DUF454)
H7K70_RS20055	COG2200	EAL domain
H7K70_RS20055	COG2199	diguanylate cyclase activity
H7K70_RS20075	COG4772	TonB-dependent receptor
H7K70_RS20080	COG2188	Transcriptional regulator
H7K70_RS20105	COG3842	ATPase activity
H7K70_RS20130	COG2814	Major facilitator Superfamily
H7K70_RS20135	COG1566	PFAM secretion protein HlyD family protein
H7K70_RS20145	COG1846	Transcriptional regulator
H7K70_RS20160	COG1309	transcriptional regulator
H7K70_RS20190	COG1846	Transcriptional regulator
H7K70_RS20205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS20220	COG2909	trisaccharide binding
H7K70_RS20235	COG4104	PAAR repeat-containing protein
H7K70_RS20255	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS20300	COG0531	amino acid
H7K70_RS20325	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS20350	COG1477	protein flavinylation
H7K70_RS20360	COG0288	reversible hydration of carbon dioxide
H7K70_RS20365	COG0714	Associated with various cellular activities
H7K70_RS20385	COG2304	oxidoreductase activity
H7K70_RS20405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K70_RS20420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K70_RS20425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS20465	COG0527	aspartate kinase activity
H7K70_RS20470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7K70_RS20475	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H7K70_RS20480	COG2988	succinylglutamate desuccinylase activity
H7K70_RS20560	COG1764	response to oxidative stress
H7K70_RS20570	COG1742	UPF0060 membrane protein
H7K70_RS20600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7K70_RS20605	COG3162	membrane
H7K70_RS20650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7K70_RS20660	COG0084	hydrolase, TatD family'
H7K70_RS20680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7K70_RS20690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K70_RS20695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K70_RS20710	COG0416	fatty acid biosynthetic process
H7K70_RS20715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7K70_RS20725	COG0424	maF-like protein
H7K70_RS20730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K70_RS20730	COG0616	signal peptide processing
H7K70_RS20735	COG0546	phosphoglycolate phosphatase activity
H7K70_RS20745	COG1530	ribonuclease E activity
H7K70_RS20790	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS20800	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H7K70_RS20805	COG0406	alpha-ribazole phosphatase activity
H7K70_RS20820	COG1492	cobalamin metabolic process
H7K70_RS20830	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H7K70_RS20835	COG0778	Nitroreductase
H7K70_RS20850	COG4206	TonB-dependent receptor
H7K70_RS20875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7K70_RS20885	COG0697	spore germination
H7K70_RS20895	COG0183	Belongs to the thiolase family
H7K70_RS20920	COG2853	Lipoprotein
H7K70_RS20935	COG1560	Kdo2-lipid A biosynthetic process
H7K70_RS20940	COG0850	regulation of cytokinetic process
H7K70_RS20945	COG2894	cell division
H7K70_RS20950	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7K70_RS20955	COG0564	pseudouridine synthase activity
H7K70_RS20965	COG1362	aminopeptidase activity
H7K70_RS20970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7K70_RS20990	COG0791	NLP P60 protein
H7K70_RS20995	COG0791	NLP P60 protein
H7K70_RS21030	COG3091	SprT-like family
H7K70_RS21050	COG2274	protein secretion by the type I secretion system
H7K70_RS21055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS21060	COG2205	protein histidine kinase activity
H7K70_RS21060	COG0784	Response regulator, receiver
H7K70_RS21085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K70_RS21120	COG1522	sequence-specific DNA binding
H7K70_RS21140	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
H7K70_RS21150	COG2239	Acts as a magnesium transporter
H7K70_RS21170	COG3179	chitinase
H7K70_RS21340	COG0456	acetyltransferase
H7K70_RS21340	COG0454	-acetyltransferase
H7K70_RS21370	COG0656	L-ascorbic acid biosynthetic process
H7K70_RS21415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K70_RS21460	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS21470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K70_RS21480	COG0604	alcohol dehydrogenase
H7K70_RS21480	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS21480	COG3321	synthase
H7K70_RS21510	COG3609	addiction module antidote protein, CC2985 family
H7K70_RS21525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7K70_RS21530	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7K70_RS21535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K70_RS21545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7K70_RS21555	COG0425	Belongs to the sulfur carrier protein TusA family
H7K70_RS21560	COG4783	chaperone-mediated protein folding
H7K70_RS21580	COG0602	queuosine metabolic process
H7K70_RS21585	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7K70_RS21590	COG2885	chlorophyll binding
H7K70_RS21615	COG0824	Thioesterase
H7K70_RS21620	COG2255	four-way junction helicase activity
H7K70_RS21630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7K70_RS21640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7K70_RS21650	COG0783	Belongs to the Dps family
H7K70_RS21665	COG2900	Belongs to the SlyX family
H7K70_RS21740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7K70_RS21745	COG0628	permease
H7K70_RS21755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7K70_RS21760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7K70_RS21775	COG3122	Protein conserved in bacteria
H7K70_RS21780	COG3956	TIGRFAM MazG family protein
H7K70_RS21785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K70_RS21820	COG0500	methyltransferase
H7K70_RS21840	COG0784	Response regulator, receiver
H7K70_RS21840	COG2205	protein histidine kinase activity
H7K70_RS21840	COG5002	protein histidine kinase activity
H7K70_RS21845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K70_RS21860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7K70_RS21875	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7K70_RS21875	COG0392	lysyltransferase activity
H7K70_RS21885	COG3038	cytochrome b561
H7K70_RS21895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K70_RS21930	COG0583	DNA-binding transcription factor activity
H7K70_RS21950	COG3148	PFAM DTW domain containing protein
H7K70_RS22010	COG2135	peptidase activity
H7K70_RS22040	COG4372	Transposase
H7K70_RS22045	COG3436	PFAM IS66 Orf2 family protein
H7K70_RS22065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K70_RS22070	COG0625	glutathione transferase activity
H7K70_RS22080	COG3328	transposase activity
H7K70_RS22115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K70_RS22125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K70_RS22140	COG2009	succinate dehydrogenase
H7K70_RS22150	COG4644	lycopene metabolic process
H7K70_RS22195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K70_RS22230	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K70_RS22235	COG1177	transmembrane transport
H7K70_RS22245	COG2826	transposase and inactivated derivatives, IS30 family
H7K70_RS22255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7K70_RS22265	COG1573	uracil-dna glycosylase
H7K70_RS22320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K70_RS22340	COG1917	Cupin 2, conserved barrel domain protein
H7K70_RS22340	COG2169	Transcriptional regulator
H7K70_RS22390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7K70_RS22400	COG1546	Belongs to the CinA family
H7K70_RS22440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K70_RS22445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7K70_RS22450	COG0585	pseudouridine synthase activity
H7K70_RS22455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7K70_RS22460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7K70_RS22465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7K70_RS22490	COG0148	phosphopyruvate hydratase activity
H7K70_RS22495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7K70_RS22500	COG0504	CTP synthase activity
H7K70_RS22510	COG0825	malonyl-CoA metabolic process
H7K70_RS22520	COG1115	amino acid carrier protein
H7K70_RS22525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7K70_RS22535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K70_RS22540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K70_RS22555	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K70_RS22565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7K70_RS22575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7K70_RS22580	COG0233	cytoplasmic translational termination
H7K70_RS22595	COG0052	Belongs to the universal ribosomal protein uS2 family
H7K70_RS22600	COG0024	Methionine aminopeptidase
H7K70_RS22605	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7K70_RS22610	COG0436	Aminotransferase
H7K70_RS22625	COG1393	Belongs to the ArsC family
H7K70_RS22630	COG2171	N-acyltransferase activity
H7K70_RS22645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7K70_RS22650	COG1979	alcohol dehydrogenase
H7K70_RS22655	COG1215	transferase activity, transferring glycosyl groups
H7K70_RS22665	COG2226	methyltransferase
H7K70_RS22685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7K70_RS22690	COG0243	molybdopterin cofactor binding
H7K70_RS22705	COG3842	ATPase activity
H7K70_RS22715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7K70_RS22720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K70_RS22740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7K70_RS22755	COG0583	DNA-binding transcription factor activity
H7K70_RS22760	COG0583	DNA-binding transcription factor activity
H7K70_RS22770	COG0183	Belongs to the thiolase family
H7K70_RS22775	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS22780	COG1024	Enoyl-CoA hydratase
H7K70_RS22785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K70_RS22790	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS22795	COG0583	DNA-binding transcription factor activity
H7K70_RS22800	COG0477	Major facilitator Superfamily
H7K70_RS22805	COG0531	amino acid
H7K70_RS22820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS22825	COG0174	glutamine synthetase
H7K70_RS22900	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7K70_RS22955	COG0745	RESPONSE REGULATOR receiver
H7K70_RS22960	COG5002	protein histidine kinase activity
H7K70_RS22960	COG5000	phosphorelay sensor kinase activity
H7K70_RS22990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K70_RS23035	COG0789	Transcriptional regulator
H7K70_RS23055	COG0784	Response regulator, receiver
H7K70_RS23060	COG4251	negative regulation of phosphorylation
H7K70_RS23075	COG0579	oxidoreductase
H7K70_RS23090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7K70_RS23130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7K70_RS23145	COG2199	diguanylate cyclase activity
H7K70_RS23150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7K70_RS23175	COG1842	Phage shock protein A
H7K70_RS23180	COG3789	protein conserved in bacteria
H7K70_RS23185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K70_RS23245	COG1607	acyl-coa hydrolase
H7K70_RS23250	COG2205	protein histidine kinase activity
H7K70_RS23250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS23255	COG0335	large ribosomal subunit rRNA binding
H7K70_RS23260	COG0336	Belongs to the RNA methyltransferase TrmD family
H7K70_RS23265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7K70_RS23270	COG0228	four-way junction DNA binding
H7K70_RS23275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7K70_RS23285	COG4536	flavin adenine dinucleotide binding
H7K70_RS23290	COG0477	Major facilitator Superfamily
H7K70_RS23315	COG0494	nUDIX hydrolase
H7K70_RS23325	COG3034	peptidoglycan biosynthetic process
H7K70_RS23330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7K70_RS23345	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K70_RS23355	COG0590	tRNA wobble adenosine to inosine editing
H7K70_RS23365	COG1178	ABC-type Fe3 transport system permease component
H7K70_RS23390	COG0583	DNA-binding transcription factor activity
H7K70_RS23400	COG1570	exodeoxyribonuclease VII activity
H7K70_RS23405	COG0739	heme binding
H7K70_RS23410	COG0668	transmembrane transport
H7K70_RS23415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K70_RS23430	COG1733	regulation of RNA biosynthetic process
H7K70_RS23440	COG0436	Aminotransferase
H7K70_RS23445	COG1160	GTP binding
H7K70_RS23455	COG2976	Protein conserved in bacteria
H7K70_RS23510	COG0316	Belongs to the HesB IscA family
H7K70_RS23520	COG1104	cysteine desulfurase activity
H7K70_RS23545	COG3134	Outer membrane lipoprotein
H7K70_RS23560	COG1862	Preprotein translocase
H7K70_RS23570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7K70_RS23580	COG1278	Cold shock
H7K70_RS23590	COG0795	lipopolysaccharide-transporting ATPase activity
H7K70_RS23595	COG0795	lipopolysaccharide-transporting ATPase activity
H7K70_RS23620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7K70_RS23630	COG0154	amidase activity
H7K70_RS23640	COG0471	metal ion transport
H7K70_RS23640	COG0490	domain, Protein
H7K70_RS23660	COG0419	ATPase involved in DNA repair
H7K70_RS23665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS23670	COG0420	3'-5' exonuclease activity
H7K70_RS23690	COG3081	Nucleoid-associated protein
H7K70_RS23695	COG1595	DNA-templated transcription, initiation
H7K70_RS23735	COG1126	abc transporter atp-binding protein
H7K70_RS23740	COG0765	amino acid transport
H7K70_RS23745	COG4597	amino acid ABC transporter
H7K70_RS23750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS23755	COG0400	carboxylic ester hydrolase activity
H7K70_RS23760	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS23810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7K70_RS23815	COG0315	cyclic pyranopterin monophosphate synthase activity
H7K70_RS23820	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7K70_RS23855	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7K70_RS23905	COG0300	oxidoreductase activity
H7K70_RS23935	COG0697	spore germination
H7K70_RS23940	COG2207	Transcriptional regulator
H7K70_RS23945	COG1595	DNA-templated transcription, initiation
H7K70_RS23950	COG3712	iron ion homeostasis
H7K70_RS23975	COG4774	siderophore transport
H7K70_RS23980	COG3712	iron ion homeostasis
H7K70_RS23985	COG1595	DNA-templated transcription, initiation
H7K70_RS24025	COG3437	response regulator, receiver
H7K70_RS24030	COG2205	protein histidine kinase activity
H7K70_RS24030	COG0784	Response regulator, receiver
H7K70_RS24030	COG5002	protein histidine kinase activity
H7K70_RS24035	COG2172	sigma factor antagonist activity
H7K70_RS24060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7K70_RS24075	COG2197	response regulator
H7K70_RS24095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7K70_RS24105	COG2207	Transcriptional regulator
H7K70_RS24110	COG1073	alpha beta
H7K70_RS24120	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS24145	COG1346	cytolysis
H7K70_RS24155	COG0583	DNA-binding transcription factor activity
H7K70_RS24170	COG1366	Belongs to the anti-sigma-factor antagonist family
H7K70_RS24195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7K70_RS24215	COG0492	ferredoxin-NADP+ reductase activity
H7K70_RS24230	COG1307	EDD domain protein, DegV family
H7K70_RS24240	COG1309	transcriptional regulator
H7K70_RS24245	COG0386	Belongs to the glutathione peroxidase family
H7K70_RS24270	COG0204	Acyl-transferase
H7K70_RS24295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K70_RS24350	COG2267	carboxylic ester hydrolase activity
H7K70_RS24380	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS24385	COG0183	Belongs to the thiolase family
H7K70_RS24400	COG1280	lysine exporter protein (LysE YggA)
H7K70_RS24405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K70_RS24415	COG0833	amino acid
H7K70_RS24420	COG2119	membrane
H7K70_RS24430	COG0501	Belongs to the peptidase M48B family
H7K70_RS24435	COG0840	transmembrane signaling receptor activity
H7K70_RS24460	COG2135	peptidase activity
H7K70_RS24495	COG0659	secondary active sulfate transmembrane transporter activity
H7K70_RS24505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7K70_RS24510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7K70_RS24520	COG2271	Major facilitator Superfamily
H7K70_RS24525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7K70_RS24530	COG1090	epimerase
H7K70_RS24535	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H7K70_RS24545	COG0789	Transcriptional regulator
H7K70_RS24550	COG0415	Belongs to the DNA photolyase family
H7K70_RS24560	COG4221	oxidoreductase activity
H7K70_RS24575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K70_RS24590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7K70_RS24595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7K70_RS24610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7K70_RS24620	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7K70_RS24625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7K70_RS24645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7K70_RS24670	COG0174	glutamine synthetase
H7K70_RS24680	COG0531	amino acid
H7K70_RS24690	COG2423	ornithine cyclodeaminase activity
H7K70_RS24700	COG0789	Transcriptional regulator
H7K70_RS24705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K70_RS24710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7K70_RS24715	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7K70_RS24725	COG1116	anion transmembrane transporter activity
H7K70_RS24750	COG1192	Involved in chromosome partitioning
H7K70_RS24795	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS24815	COG0288	reversible hydration of carbon dioxide
H7K70_RS24820	COG0456	acetyltransferase
H7K70_RS24830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K70_RS24880	COG3008	intermembrane lipid transfer
H7K70_RS24885	COG2995	paraquat-inducible protein a
H7K70_RS24890	COG2995	paraquat-inducible protein a
H7K70_RS24925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7K70_RS24930	COG1183	phosphatidylcholine synthase activity
H7K70_RS24940	COG0583	DNA-binding transcription factor activity
H7K70_RS24950	COG0028	Belongs to the TPP enzyme family
H7K70_RS24960	COG3098	single-species biofilm formation
H7K70_RS24970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7K70_RS24995	COG0813	purine-nucleoside phosphorylase activity
H7K70_RS25000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7K70_RS25015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K70_RS25020	COG4558	Periplasmic binding protein
H7K70_RS25025	COG3720	iron ion transport
H7K70_RS25040	COG0436	Aminotransferase
H7K70_RS25045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7K70_RS25050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K70_RS25060	COG4191	Histidine kinase
H7K70_RS25080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7K70_RS25170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7K70_RS25190	COG0195	Participates in both transcription termination and antitermination
H7K70_RS25195	COG0779	Required for maturation of 30S ribosomal subunits
H7K70_RS25210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7K70_RS25220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K70_RS25225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7K70_RS25280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7K70_RS25285	COG0497	DNA recombination
H7K70_RS25295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K70_RS25310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7K70_RS25315	COG2186	Transcriptional regulator
H7K70_RS25320	COG1620	l-lactate permease
H7K70_RS25340	COG2205	protein histidine kinase activity
H7K70_RS25390	COG2226	methyltransferase
H7K70_RS25395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K70_RS25400	COG0697	spore germination
H7K70_RS25415	COG3268	Saccharopine dehydrogenase
H7K70_RS25420	COG0640	Transcriptional regulator
H7K70_RS25425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7K70_RS25430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7K70_RS25455	COG1113	amino acid transport
H7K70_RS25465	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS25485	COG1309	transcriptional regulator
H7K70_RS25495	COG0583	DNA-binding transcription factor activity
H7K70_RS25505	COG3845	ABC transporter
H7K70_RS25510	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7K70_RS25515	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K70_RS25520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K70_RS25535	COG2072	flavoprotein involved in K transport
H7K70_RS25560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K70_RS25580	COG1294	oxidase, subunit
H7K70_RS25585	COG4890	Cyd operon protein YbgT
H7K70_RS25620	COG0583	DNA-binding transcription factor activity
H7K70_RS25625	COG1309	transcriptional regulator
H7K70_RS25685	COG1943	Transposase
H7K70_RS25730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7K70_RS25735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7K70_RS25740	COG2814	Major facilitator Superfamily
H7K70_RS25755	COG5001	Diguanylate cyclase
H7K70_RS25755	COG5002	protein histidine kinase activity
H7K70_RS25755	COG3447	MASE1 domain protein
H7K70_RS25760	COG0583	DNA-binding transcription factor activity
H7K70_RS25765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7K70_RS25780	COG2814	Major facilitator Superfamily
H7K70_RS25835	COG3415	Transposase
H7K70_RS25835	COG2801	Transposase and inactivated derivatives
H7K70_RS25840	COG2217	Heavy metal translocating P-type atpase
H7K70_RS25870	COG2910	NAD(P)H-binding
H7K70_RS25880	COG3152	Membrane
H7K70_RS25895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7K70_RS25900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7K70_RS25910	COG1238	metal cluster binding
H7K70_RS25920	COG0443	Heat shock 70 kDa protein
H7K70_RS25935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K70_RS25940	COG2193	ferroxidase activity
H7K70_RS25950	COG2982	Protein involved in outer membrane biogenesis
H7K70_RS25985	COG0830	nickel cation binding
H7K70_RS25990	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7K70_RS26005	COG0584	glycerophosphoryl diester phosphodiesterase
H7K70_RS26010	COG4221	oxidoreductase activity
H7K70_RS26015	COG2423	ornithine cyclodeaminase activity
H7K70_RS26040	COG0683	leucine binding
H7K70_RS26045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS26050	COG1012	belongs to the aldehyde dehydrogenase family
H7K70_RS26055	COG0583	DNA-binding transcription factor activity
H7K70_RS26105	COG1305	Transglutaminase-like
H7K70_RS26125	COG0305	Participates in initiation and elongation during chromosome replication
H7K70_RS26130	COG0359	binds to the 23S rRNA
H7K70_RS26140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7K70_RS26145	COG0360	Binds together with S18 to 16S ribosomal RNA
H7K70_RS26155	COG0557	exoribonuclease II activity
H7K70_RS26175	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H7K70_RS26185	COG0330	HflC and HflK could
H7K70_RS26190	COG0330	HflC and HflK could
H7K70_RS26195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7K70_RS26200	COG1923	regulation of RNA biosynthetic process
H7K70_RS26205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7K70_RS26210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7K70_RS26215	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7K70_RS26220	COG0802	atpase or kinase
H7K70_RS26225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7K70_RS26225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7K70_RS26235	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7K70_RS26240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7K70_RS26245	COG1162	GTPase activity
H7K70_RS26250	COG1360	Flagellar Motor Protein
H7K70_RS26270	COG0688	phosphatidylethanolamine metabolic process
H7K70_RS26285	COG3830	Belongs to the UPF0237 family
H7K70_RS26285	COG0560	Phosphoserine phosphatase
H7K70_RS26295	COG1988	membrane-bound metal-dependent
H7K70_RS26310	COG3577	Aspartyl protease
H7K70_RS26325	COG3150	esterase
H7K70_RS26330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7K70_RS26340	COG0494	nUDIX hydrolase
H7K70_RS26355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7K70_RS26360	COG1538	Outer membrane efflux protein
H7K70_RS26385	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS26390	COG1024	Enoyl-CoA hydratase
H7K70_RS26395	COG0833	amino acid
H7K70_RS26420	COG1396	sequence-specific DNA binding
H7K70_RS26430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K70_RS26435	COG0235	Class ii aldolase
H7K70_RS26445	COG1902	pentaerythritol trinitrate reductase activity
H7K70_RS26445	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K70_RS26455	COG1519	Transferase
H7K70_RS26460	COG0583	DNA-binding transcription factor activity
H7K70_RS26475	COG0656	L-ascorbic acid biosynthetic process
H7K70_RS26485	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS26495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7K70_RS26495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7K70_RS26510	COG1132	(ABC) transporter
H7K70_RS26525	COG1215	transferase activity, transferring glycosyl groups
H7K70_RS26545	COG0438	transferase activity, transferring glycosyl groups
H7K70_RS26550	COG2192	nodulation
H7K70_RS26575	COG0438	transferase activity, transferring glycosyl groups
H7K70_RS26585	COG0859	PFAM glycosyl transferase family 9
H7K70_RS26620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K70_RS26625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7K70_RS26630	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS26660	COG3263	regulation of cellular component size
H7K70_RS26665	COG1196	nuclear chromosome segregation
H7K70_RS26665	COG3264	Mechanosensitive ion channel
H7K70_RS26670	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7K70_RS26675	COG1794	racemase activity, acting on amino acids and derivatives
H7K70_RS26680	COG0730	response to heat
H7K70_RS26685	COG2873	o-acetylhomoserine
H7K70_RS26690	COG3118	belongs to the thioredoxin family
H7K70_RS26710	COG1192	Involved in chromosome partitioning
H7K70_RS26730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K70_RS26755	COG2986	histidine ammonia-lyase
H7K70_RS26805	COG1028	Short-chain dehydrogenase reductase Sdr
H7K70_RS26810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K70_RS26835	COG0493	'glutamate synthase
H7K70_RS26840	COG0067	glutamate synthase
H7K70_RS26840	COG0070	glutamate synthase
H7K70_RS26840	COG0069	glutamate synthase activity
H7K70_RS26850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7K70_RS26855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K70_RS26890	COG0281	malic enzyme
H7K70_RS26900	COG0254	rRNA binding
H7K70_RS26905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7K70_RS26910	COG0018	arginyl-trna synthetase
H7K70_RS26925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7K70_RS26950	COG1309	transcriptional regulator
H7K70_RS26990	COG0140	phosphoribosyl-ATP diphosphatase activity
H7K70_RS27015	COG0840	transmembrane signaling receptor activity
H7K70_RS27020	COG0840	transmembrane signaling receptor activity
H7K70_RS27035	COG0765	amino acid transport
H7K70_RS27045	COG1490	D-aminoacyl-tRNA deacylase activity
H7K70_RS27050	COG0596	Alpha beta hydrolase
H7K70_RS27060	COG1943	Transposase
H7K70_RS27075	COG2056	Na+-H+ antiporter family
H7K70_RS27090	COG3314	Sporulation integral membrane protein YlbJ
H7K70_RS27105	COG0402	S-adenosylhomocysteine deaminase activity
H7K70_RS27125	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7K70_RS27150	COG2354	Protein conserved in bacteria
H7K70_RS27155	COG2194	sulfuric ester hydrolase activity
H7K70_RS27170	COG2860	membrane
H7K70_RS27180	COG1217	gtp-binding protein TYPA
H7K70_RS27185	COG0301	tRNA thio-modification
H7K70_RS27185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K70_RS27205	COG3852	Histidine kinase
H7K70_RS27220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7K70_RS27225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7K70_RS27235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K70_RS27240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7K70_RS27245	COG4942	peptidase
H7K70_RS27250	COG0793	Belongs to the peptidase S41A family
H7K70_RS27255	COG2861	carbohydrate metabolic process
H7K70_RS27285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7K70_RS27300	COG0131	Imidazoleglycerol-phosphate dehydratase
H7K70_RS27305	COG2223	nitrite transmembrane transporter activity
H7K70_RS27325	COG1194	a g-specific adenine glycosylase
H7K70_RS27345	COG0318	PFAM AMP-dependent synthetase and ligase
H7K70_RS27375	COG2205	protein histidine kinase activity
H7K70_RS27375	COG0784	Response regulator, receiver
H7K70_RS27385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7K70_RS27390	COG4999	Histidine kinase
H7K70_RS27390	COG3850	Histidine kinase
H7K70_RS27390	COG2205	protein histidine kinase activity
H7K70_RS27390	COG3437	response regulator, receiver
H7K70_RS27410	COG4215	(ABC) transporter
H7K70_RS27495	COG0494	nUDIX hydrolase
H7K70_RS27500	COG1011	Hydrolase
H7K70_RS27505	COG0583	DNA-binding transcription factor activity
H7K70_RS27510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K70_RS27540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7K70_RS27550	COG1454	alcohol dehydrogenase
H7K70_RS27555	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS27560	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K70_RS27560	COG1024	Enoyl-CoA hydratase
H7K70_RS27595	COG2183	response to ionizing radiation
H7K70_RS27615	COG0189	ligase activity
H7K70_RS27620	COG0189	ligase activity
H7K70_RS27620	COG4067	protein conserved in archaea
H7K70_RS27625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7K70_RS27630	COG0671	phosphoesterase, PA-phosphatase related
H7K70_RS27650	COG0778	Nitroreductase
H7K70_RS27655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7K70_RS27655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7K70_RS27665	COG3025	triphosphatase activity
H7K70_RS27675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7K70_RS27680	COG1522	sequence-specific DNA binding
H7K70_RS27690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7K70_RS27695	COG0330	HflC and HflK could
H7K70_RS27715	COG2957	Belongs to the agmatine deiminase family
H7K70_RS27730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K70_RS27735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K70_RS27740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K70_RS27745	COG0431	NADPH-dependent FMN reductase
H7K70_RS27750	COG0450	alkyl hydroperoxide reductase
H7K70_RS27760	COG4521	taurine ABC transporter
H7K70_RS27765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7K70_RS27770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K70_RS27775	COG2175	clavaminate synthase activity
H7K70_RS27785	COG0626	cystathionine gamma-synthase activity
H7K70_RS27795	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H7K70_RS27800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K70_RS27805	COG0765	amino acid transport
H7K70_RS27810	COG1126	abc transporter atp-binding protein
H7K70_RS27815	COG2814	Major facilitator Superfamily
H7K70_RS27850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7K70_RS27870	COG3052	prosthetic group binding
H7K70_RS27875	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7K70_RS27935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K70_RS27940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K70_RS27955	COG2199	diguanylate cyclase activity
H7K70_RS27965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K70_RS27970	COG0583	DNA-binding transcription factor activity
H7K70_RS27995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7K70_RS28005	COG4208	sulfate ABC transporter
H7K70_RS28040	COG0840	transmembrane signaling receptor activity
H7K70_RS28065	COG1309	transcriptional regulator
H7K70_RS28070	COG4221	oxidoreductase activity
H7K70_RS28080	COG1639	'signal transduction protein
H7K70_RS28110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS28110	COG2022	thiamine diphosphate biosynthetic process
H7K70_RS28140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K70_RS28145	COG1960	acyl-CoA dehydrogenase activity
H7K70_RS28150	COG0583	DNA-binding transcription factor activity
H7K70_RS28185	COG0210	DNA helicase
H7K70_RS28195	COG0826	peptidase U32
H7K70_RS28200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7K70_RS28210	COG1414	Transcriptional regulator
H7K70_RS28220	COG0765	amino acid transport
H7K70_RS28225	COG1126	abc transporter atp-binding protein
H7K70_RS28230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K70_RS28235	COG4774	siderophore transport
H7K70_RS28240	COG3712	iron ion homeostasis
H7K70_RS28255	COG0583	DNA-binding transcription factor activity
H7K70_RS28260	COG0439	Biotin carboxylase
H7K70_RS28265	COG5016	pyruvate
H7K70_RS28265	COG0511	ligase activity, forming carbon-carbon bonds
H7K70_RS28300	COG0583	DNA-binding transcription factor activity
H7K70_RS28345	COG1115	amino acid carrier protein
H7K70_RS28350	COG0252	asparaginase activity
H7K70_RS28355	COG0427	acetyl-CoA hydrolase
H7K70_RS28400	COG2851	Citrate transporter
H7K70_RS28405	COG0861	Integral membrane protein TerC family
H7K70_RS28415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H7K70_RS28420	COG1690	Belongs to the RtcB family
H7K70_RS28425	COG0739	heme binding
H7K70_RS28440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7K70_RS28445	COG0573	inorganic phosphate transmembrane transporter activity
H7K70_RS28470	COG1607	acyl-coa hydrolase
H7K70_RS28485	COG2153	protein acetylation
H7K70_RS28495	COG4651	solute:proton antiporter activity
H7K70_RS28495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7K70_RS28505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7K70_RS28510	COG0174	glutamine synthetase
H7K70_RS28520	COG1607	acyl-coa hydrolase
H7K70_RS28535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7K70_RS28560	COG4191	Histidine kinase
H7K70_RS28565	COG2204	response regulator
H7K70_RS28570	COG0477	Major facilitator Superfamily
H7K70_RS28575	COG0523	cobalamin synthesis protein
H7K70_RS28600	COG1469	GTP cyclohydrolase I activity
H7K70_RS28650	COG0754	glutathionylspermidine amidase activity
H7K70_RS28670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7K70_RS28675	COG1349	DNA-binding transcription factor activity
H7K70_RS28680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7K70_RS28695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7K70_RS28705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7K70_RS28710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7K70_RS28725	COG3312	ion transport
H7K70_RS28730	COG1475	DNA binding
H7K70_RS28735	COG1192	Involved in chromosome partitioning
H7K70_RS28740	COG0357	Ribosomal RNA small subunit methyltransferase G
H7K70_RS28750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7K70_RS28755	COG0706	membrane insertase activity
H7K70_RS28760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7K70_RS28765	COG0594	ribonuclease P activity
H7K70_RS28770	COG0230	Belongs to the bacterial ribosomal protein bL34 family