locus-tag	class	description
RK21_RS00015	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RK21_RS00020	COG1074	ATP-dependent DNA helicase activity
RK21_RS00025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RK21_RS00035	COG2199	diguanylate cyclase activity
RK21_RS00085	COG4589	Belongs to the CDS family
RK21_RS00100	COG2453	phosphatase
RK21_RS00100	COG0671	phosphoesterase, PA-phosphatase related
RK21_RS00105	COG2267	carboxylic ester hydrolase activity
RK21_RS00110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RK21_RS00130	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK21_RS00135	COG0583	DNA-binding transcription factor activity
RK21_RS00145	COG0840	transmembrane signaling receptor activity
RK21_RS00150	COG2321	neutral zinc metallopeptidase
RK21_RS00155	COG3485	protocatechuate 3,4-dioxygenase
RK21_RS00160	COG3485	protocatechuate 3,4-dioxygenase
RK21_RS00165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RK21_RS00170	COG2252	PERMEase
RK21_RS00180	COG1271	oxidase subunit
RK21_RS00185	COG1294	oxidase, subunit
RK21_RS00195	COG2813	Specifically methylates the guanine in position
RK21_RS00200	COG2197	response regulator
RK21_RS00210	COG1970	mechanosensitive ion channel activity
RK21_RS00220	COG2233	PERMEase
RK21_RS00230	COG1966	Carbon starvation protein
RK21_RS00235	COG2879	small protein
RK21_RS00240	COG0523	cobalamin synthesis protein
RK21_RS00250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RK21_RS00270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RK21_RS00310	COG1366	Belongs to the anti-sigma-factor antagonist family
RK21_RS00320	COG0583	DNA-binding transcription factor activity
RK21_RS00325	COG1380	Effector of murein hydrolase LrgA
RK21_RS00330	COG1346	cytolysis
RK21_RS00335	COG0596	Alpha beta hydrolase
RK21_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS00350	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RK21_RS00425	COG2207	Transcriptional regulator
RK21_RS00425	COG3708	Transcriptional regulator
RK21_RS00440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK21_RS00445	COG0583	DNA-binding transcription factor activity
RK21_RS00465	COG1566	PFAM secretion protein HlyD family protein
RK21_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS00505	COG0300	oxidoreductase activity
RK21_RS00515	COG0662	Cupin 2, conserved barrel domain protein
RK21_RS00515	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RK21_RS00530	COG1696	Membrane protein involved in D-alanine export
RK21_RS00545	COG3420	alginic acid biosynthetic process
RK21_RS00555	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RK21_RS00560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS00565	COG1215	transferase activity, transferring glycosyl groups
RK21_RS00570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RK21_RS00575	COG3022	response to hydroperoxide
RK21_RS00585	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RK21_RS00590	COG0315	cyclic pyranopterin monophosphate synthase activity
RK21_RS00595	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RK21_RS00605	COG0513	Belongs to the DEAD box helicase family
RK21_RS00610	COG0400	carboxylic ester hydrolase activity
RK21_RS00615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS00620	COG4597	amino acid ABC transporter
RK21_RS00625	COG0765	amino acid transport
RK21_RS00630	COG1126	abc transporter atp-binding protein
RK21_RS00635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RK21_RS00645	COG0175	sulfate reduction
RK21_RS00655	COG1522	sequence-specific DNA binding
RK21_RS00675	COG0180	Tryptophanyl-tRNA synthetase
RK21_RS00680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RK21_RS00690	COG0667	Aldo Keto reductase
RK21_RS00695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RK21_RS00700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RK21_RS00705	COG0723	plastoquinol--plastocyanin reductase activity
RK21_RS00710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RK21_RS00715	COG2857	Cytochrome c1
RK21_RS00720	COG0625	glutathione transferase activity
RK21_RS00725	COG2969	positive regulation of protein catabolic process
RK21_RS00735	COG2823	Periplasmic or secreted lipoprotein
RK21_RS00740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RK21_RS00745	COG0792	nuclease activity
RK21_RS00750	COG3107	peptidoglycan biosynthetic process
RK21_RS00760	COG2001	Belongs to the MraZ family
RK21_RS00765	COG0275	rRNA processing
RK21_RS00780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RK21_RS00785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RK21_RS00790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RK21_RS00795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RK21_RS00800	COG0772	Belongs to the SEDS family
RK21_RS00805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RK21_RS00810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RK21_RS00815	COG1181	Belongs to the D-alanine--D-alanine ligase family
RK21_RS00830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RK21_RS00835	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RK21_RS00845	COG0653	protein targeting
RK21_RS00850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RK21_RS00860	COG0352	thiamine-phosphate diphosphorylase activity
RK21_RS00865	COG2096	Adenosyltransferase
RK21_RS00880	COG1666	GTP binding
RK21_RS00885	COG0668	transmembrane transport
RK21_RS00920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RK21_RS00925	COG0459	protein refolding
RK21_RS00950	COG3642	lipopolysaccharide core region biosynthetic process
RK21_RS00960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK21_RS00965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS01005	COG3622	Belongs to the hyi family
RK21_RS01010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RK21_RS01020	COG0583	DNA-binding transcription factor activity
RK21_RS01025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK21_RS01035	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS01080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK21_RS01085	COG0693	protein deglycase activity
RK21_RS01100	COG3153	acetyltransferase
RK21_RS01100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK21_RS01115	COG0469	pyruvate kinase activity
RK21_RS01130	COG2925	Exonuclease
RK21_RS01140	COG0788	formyltetrahydrofolate deformylase activity
RK21_RS01160	COG0840	transmembrane signaling receptor activity
RK21_RS01165	COG0433	COG0433 Predicted ATPase
RK21_RS01170	COG0306	phosphate transporter
RK21_RS01180	COG1414	Transcriptional regulator
RK21_RS01185	COG2814	Major facilitator Superfamily
RK21_RS01190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RK21_RS01195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RK21_RS01200	COG0183	Belongs to the thiolase family
RK21_RS01205	COG0477	Major facilitator Superfamily
RK21_RS01210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RK21_RS01215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RK21_RS01220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK21_RS01245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS01250	COG1309	transcriptional regulator
RK21_RS01255	COG0477	Major facilitator Superfamily
RK21_RS01260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RK21_RS01275	COG2910	NAD(P)H-binding
RK21_RS01280	COG0583	DNA-binding transcription factor activity
RK21_RS01290	COG2207	Transcriptional regulator
RK21_RS01320	COG0477	Major facilitator Superfamily
RK21_RS01330	COG4191	Histidine kinase
RK21_RS01390	COG1024	Enoyl-CoA hydratase
RK21_RS01395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RK21_RS01400	COG3180	Ammonia monooxygenase
RK21_RS01440	COG0354	folic acid binding
RK21_RS01445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RK21_RS01475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RK21_RS01485	COG0481	GTPase activity
RK21_RS01490	COG0681	Belongs to the peptidase S26 family
RK21_RS01495	COG0571	ribonuclease III activity
RK21_RS01500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RK21_RS01505	COG1381	Involved in DNA repair and RecF pathway recombination
RK21_RS01510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RK21_RS01515	COG0642	Histidine kinase
RK21_RS01530	COG0500	methyltransferase
RK21_RS01535	COG2226	methyltransferase
RK21_RS01545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RK21_RS01560	COG4206	TonB-dependent receptor
RK21_RS01565	COG4628	conserved protein (DUF2132)
RK21_RS01575	COG2375	cellular response to nickel ion
RK21_RS01580	COG1695	Transcriptional regulator
RK21_RS01590	COG1113	amino acid transport
RK21_RS01595	COG0069	glutamate synthase activity
RK21_RS01600	COG1201	RNA secondary structure unwinding
RK21_RS01605	COG0494	nUDIX hydrolase
RK21_RS01610	COG0583	DNA-binding transcription factor activity
RK21_RS01615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RK21_RS01635	COG1126	abc transporter atp-binding protein
RK21_RS01640	COG0765	amino acid transport
RK21_RS01645	COG0765	amino acid transport
RK21_RS01650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS01670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RK21_RS01680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RK21_RS01685	COG3842	ATPase activity
RK21_RS01690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RK21_RS01695	COG0243	molybdopterin cofactor binding
RK21_RS01700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RK21_RS01720	COG0450	alkyl hydroperoxide reductase
RK21_RS01725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK21_RS01730	COG0418	dihydroorotase activity
RK21_RS01740	COG0137	argininosuccinate synthase activity
RK21_RS01750	COG2197	response regulator
RK21_RS01760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RK21_RS01770	COG4659	FMN binding
RK21_RS01785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK21_RS01785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK21_RS01790	COG0489	protein tyrosine kinase activity
RK21_RS01795	COG1278	Cold shock
RK21_RS01800	COG0717	Belongs to the dCTP deaminase family
RK21_RS01810	COG1201	RNA secondary structure unwinding
RK21_RS01820	COG1793	dna ligase
RK21_RS01825	COG1793	dna ligase
RK21_RS01825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RK21_RS01830	COG2366	antibiotic biosynthetic process
RK21_RS01835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS01840	COG2814	Major facilitator Superfamily
RK21_RS01845	COG0653	protein targeting
RK21_RS01855	COG3012	SEC-C Motif Domain Protein
RK21_RS01890	COG1199	ATP-dependent helicase activity
RK21_RS01905	COG2885	chlorophyll binding
RK21_RS01910	COG0259	pyridoxamine-phosphate oxidase activity
RK21_RS01925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK21_RS01930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RK21_RS01975	COG2084	Dehydrogenase
RK21_RS01985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RK21_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS02025	COG0583	DNA-binding transcription factor activity
RK21_RS02035	COG3300	MHYT domain
RK21_RS02035	COG5001	Diguanylate cyclase
RK21_RS02040	COG3706	GGDEF domain
RK21_RS02050	COG2116	formate transmembrane transporter activity
RK21_RS02090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK21_RS02100	COG0252	asparaginase activity
RK21_RS02105	COG3318	Belongs to the UPF0149 family
RK21_RS02105	COG3012	SEC-C Motif Domain Protein
RK21_RS02110	COG0625	glutathione transferase activity
RK21_RS02120	COG0583	DNA-binding transcription factor activity
RK21_RS02155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK21_RS02160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK21_RS02160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RK21_RS02170	COG0745	RESPONSE REGULATOR receiver
RK21_RS02175	COG2205	protein histidine kinase activity
RK21_RS02205	COG1301	dicarboxylic acid transport
RK21_RS02215	COG4807	Protein conserved in bacteria
RK21_RS02225	COG0519	Catalyzes the synthesis of GMP from XMP
RK21_RS02250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RK21_RS02255	COG3158	transport of potassium into the cell
RK21_RS02280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RK21_RS02290	COG0442	prolyl-tRNA aminoacylation
RK21_RS02305	COG2900	Belongs to the SlyX family
RK21_RS02315	COG0783	Belongs to the Dps family
RK21_RS02330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RK21_RS02335	COG0217	transcriptional regulatory protein
RK21_RS02340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RK21_RS02345	COG0632	four-way junction helicase activity
RK21_RS02350	COG2255	four-way junction helicase activity
RK21_RS02355	COG0824	Thioesterase
RK21_RS02375	COG0823	Involved in the tonB-independent uptake of proteins
RK21_RS02380	COG2885	chlorophyll binding
RK21_RS02385	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RK21_RS02390	COG0602	queuosine metabolic process
RK21_RS02395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RK21_RS02410	COG0840	transmembrane signaling receptor activity
RK21_RS02415	COG0531	amino acid
RK21_RS02425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RK21_RS02430	COG4783	chaperone-mediated protein folding
RK21_RS02435	COG0425	Belongs to the sulfur carrier protein TusA family
RK21_RS02445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RK21_RS02455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK21_RS02460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RK21_RS02465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RK21_RS02470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RK21_RS02515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK21_RS02520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK21_RS02530	COG3938	Belongs to the proline racemase family
RK21_RS02535	COG0579	oxidoreductase
RK21_RS02550	COG0640	Transcriptional regulator
RK21_RS02555	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS02560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS02570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK21_RS02575	COG3938	Belongs to the proline racemase family
RK21_RS02580	COG0531	amino acid
RK21_RS02595	COG0521	Mo-molybdopterin cofactor biosynthetic process
RK21_RS02600	COG3781	membrane
RK21_RS02605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RK21_RS02610	COG0243	molybdopterin cofactor binding
RK21_RS02615	COG1522	sequence-specific DNA binding
RK21_RS02620	COG0626	cystathionine gamma-synthase activity
RK21_RS02635	COG2194	sulfuric ester hydrolase activity
RK21_RS02645	COG3100	YcgL domain-containing protein
RK21_RS02650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK21_RS02660	COG2983	Belongs to the UPF0260 family
RK21_RS02670	COG2801	Transposase and inactivated derivatives
RK21_RS02710	COG0121	glutamine amidotransferase
RK21_RS02725	COG2814	Major facilitator Superfamily
RK21_RS02730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RK21_RS02735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RK21_RS02740	COG1984	allophanate hydrolase subunit 2
RK21_RS02760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RK21_RS02845	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RK21_RS02870	COG1295	ribonuclease BN
RK21_RS02875	COG0242	peptide deformylase activity
RK21_RS02895	COG3795	YCII-related domain
RK21_RS02905	COG4941	Belongs to the sigma-70 factor family
RK21_RS02910	COG2030	dehydratase
RK21_RS02915	COG2267	carboxylic ester hydrolase activity
RK21_RS02920	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS02925	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS02930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS02935	COG0174	glutamine synthetase
RK21_RS02940	COG1643	Atp-dependent helicase
RK21_RS02950	COG2188	Transcriptional regulator
RK21_RS02960	COG1132	(ABC) transporter
RK21_RS02985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RK21_RS02995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RK21_RS03000	COG0668	transmembrane transport
RK21_RS03005	COG0513	Belongs to the DEAD box helicase family
RK21_RS03025	COG0697	spore germination
RK21_RS03035	COG0583	DNA-binding transcription factor activity
RK21_RS03040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK21_RS03055	COG0840	transmembrane signaling receptor activity
RK21_RS03070	COG2832	Protein of unknown function (DUF454)
RK21_RS03080	COG0514	ATP-dependent DNA helicase (RecQ)
RK21_RS03090	COG1752	Esterase of the alpha-beta hydrolase superfamily
RK21_RS03105	COG2207	Transcriptional regulator
RK21_RS03125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK21_RS03130	COG0778	Nitroreductase
RK21_RS03145	COG0745	RESPONSE REGULATOR receiver
RK21_RS03150	COG2350	Protein conserved in bacteria
RK21_RS03155	COG2917	probably involved in intracellular septation
RK21_RS03160	COG0613	PHP domain protein
RK21_RS03165	COG0009	L-threonylcarbamoyladenylate synthase
RK21_RS03175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RK21_RS03185	COG1113	amino acid transport
RK21_RS03195	COG0247	lactate metabolic process
RK21_RS03195	COG0277	FAD linked oxidase domain protein
RK21_RS03205	COG2154	pterin-4-alpha-carbinolamine dehydratase
RK21_RS03225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK21_RS03230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS03255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RK21_RS03270	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS03275	COG3724	N-succinylarginine dihydrolase activity
RK21_RS03285	COG2988	succinylglutamate desuccinylase activity
RK21_RS03295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RK21_RS03300	COG0527	aspartate kinase activity
RK21_RS03305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RK21_RS03330	COG2239	Acts as a magnesium transporter
RK21_RS03370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK21_RS03380	COG0022	dehydrogenase e1 component
RK21_RS03385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RK21_RS03390	COG1522	sequence-specific DNA binding
RK21_RS03400	COG0477	Major facilitator Superfamily
RK21_RS03405	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RK21_RS03425	COG0784	Response regulator, receiver
RK21_RS03425	COG0835	chemotaxis
RK21_RS03430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RK21_RS03445	COG1815	bacterial-type flagellum-dependent cell motility
RK21_RS03455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RK21_RS03480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RK21_RS03485	COG1706	bacterial-type flagellum-dependent cell motility
RK21_RS03495	COG1256	bacterial-type flagellum assembly
RK21_RS03505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RK21_RS03510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK21_RS03520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RK21_RS03550	COG1677	Flagellar hook-basal body complex protein FliE
RK21_RS03575	COG2882	bacterial-type flagellum organization
RK21_RS03585	COG0745	RESPONSE REGULATOR receiver
RK21_RS03625	COG1987	bacterial-type flagellum assembly
RK21_RS03640	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RK21_RS03665	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RK21_RS03670	COG0643	Histidine kinase
RK21_RS03670	COG0784	Response regulator, receiver
RK21_RS03670	COG2198	Histidine kinase
RK21_RS03675	COG2201	protein-glutamate methylesterase activity
RK21_RS03680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RK21_RS03685	COG1360	Flagellar Motor Protein
RK21_RS03690	COG1192	Involved in chromosome partitioning
RK21_RS03700	COG0835	chemotaxis
RK21_RS03750	COG2207	Transcriptional regulator
RK21_RS03755	COG2257	FlhB HrpN YscU SpaS Family
RK21_RS03770	COG4133	protoheme IX ABC transporter activity
RK21_RS03790	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RK21_RS03795	COG1138	Cytochrome C-type biogenesis protein
RK21_RS03820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK21_RS03855	COG1953	Uracil, thiamine, allantoin
RK21_RS03860	COG1522	sequence-specific DNA binding
RK21_RS03870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK21_RS03870	COG0116	Belongs to the methyltransferase superfamily
RK21_RS03880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK21_RS03890	COG0469	pyruvate kinase activity
RK21_RS03900	COG2084	Dehydrogenase
RK21_RS03905	COG3622	Belongs to the hyi family
RK21_RS03910	COG3960	tartronate-semialdehyde synthase activity
RK21_RS03925	COG2354	Protein conserved in bacteria
RK21_RS03940	COG2233	PERMEase
RK21_RS03950	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
RK21_RS03975	COG2252	PERMEase
RK21_RS03985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RK21_RS03990	COG0402	S-adenosylhomocysteine deaminase activity
RK21_RS04020	COG3115	cell septum assembly
RK21_RS04025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RK21_RS04050	COG0789	Transcriptional regulator
RK21_RS04060	COG0697	spore germination
RK21_RS04065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RK21_RS04070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RK21_RS04075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RK21_RS04080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RK21_RS04085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK21_RS04105	COG2217	Heavy metal translocating P-type atpase
RK21_RS04115	COG0348	domain, Protein
RK21_RS04120	COG2010	Cytochrome c
RK21_RS04135	COG3278	Belongs to the heme-copper respiratory oxidase family
RK21_RS04140	COG2010	Cytochrome c
RK21_RS04155	COG3278	Belongs to the heme-copper respiratory oxidase family
RK21_RS04165	COG3123	guanosine phosphorylase activity
RK21_RS04195	COG1131	(ABC) transporter
RK21_RS04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RK21_RS04265	COG0642	Histidine kinase
RK21_RS04280	COG0657	acetylesterase activity
RK21_RS04305	COG1136	(ABC) transporter
RK21_RS04305	COG0577	efflux transmembrane transporter activity
RK21_RS04310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS04355	COG2885	chlorophyll binding
RK21_RS04355	COG3047	cAMP biosynthetic process
RK21_RS04360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS04385	COG2009	succinate dehydrogenase
RK21_RS04390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RK21_RS04395	COG1053	succinate dehydrogenase
RK21_RS04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK21_RS04420	COG0045	succinate-CoA ligase (ADP-forming) activity
RK21_RS04455	COG0326	Molecular chaperone. Has ATPase activity
RK21_RS04465	COG1741	Belongs to the pirin family
RK21_RS04480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK21_RS04485	COG3437	response regulator, receiver
RK21_RS04485	COG3850	Histidine kinase
RK21_RS04485	COG4999	Histidine kinase
RK21_RS04485	COG2205	protein histidine kinase activity
RK21_RS04500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RK21_RS04530	COG0628	permease
RK21_RS04540	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RK21_RS04550	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RK21_RS04555	COG2205	protein histidine kinase activity
RK21_RS04560	COG0745	RESPONSE REGULATOR receiver
RK21_RS04580	COG0583	DNA-binding transcription factor activity
RK21_RS04585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK21_RS04605	COG4172	Belongs to the ABC transporter superfamily
RK21_RS04610	COG4239	(ABC) transporter, permease
RK21_RS04615	COG4174	ABC transporter (Permease)
RK21_RS04620	COG4166	transmembrane transport
RK21_RS04625	COG4166	transmembrane transport
RK21_RS04630	COG0741	lytic transglycosylase activity
RK21_RS04630	COG1388	LysM domain
RK21_RS04635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK21_RS04645	COG0328	RNA-DNA hybrid ribonuclease activity
RK21_RS04665	COG0431	NADPH-dependent FMN reductase
RK21_RS04700	COG1007	ATP synthesis coupled electron transport
RK21_RS04715	COG0713	ATP synthesis coupled electron transport
RK21_RS04725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RK21_RS04730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RK21_RS04735	COG1034	ATP synthesis coupled electron transport
RK21_RS04750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RK21_RS04750	COG0649	NAD binding
RK21_RS04755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RK21_RS04760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RK21_RS04790	COG0659	secondary active sulfate transmembrane transporter activity
RK21_RS04795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK21_RS04810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK21_RS04815	COG0583	DNA-binding transcription factor activity
RK21_RS04820	COG1113	amino acid transport
RK21_RS04825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RK21_RS04825	COG2050	protein possibly involved in aromatic compounds catabolism
RK21_RS04830	COG0625	glutathione transferase activity
RK21_RS04835	COG0306	phosphate transporter
RK21_RS04860	COG0322	excinuclease ABC activity
RK21_RS04875	COG0582	viral genome integration into host DNA
RK21_RS04880	COG3436	PFAM IS66 Orf2 family protein
RK21_RS04955	COG1960	acyl-CoA dehydrogenase activity
RK21_RS04975	COG2207	Transcriptional regulator
RK21_RS04980	COG1960	acyl-CoA dehydrogenase activity
RK21_RS04985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RK21_RS04990	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS04995	COG0183	Belongs to the thiolase family
RK21_RS05000	COG1024	Enoyl-CoA hydratase
RK21_RS05020	COG2963	transposase activity
RK21_RS05025	COG2801	Transposase and inactivated derivatives
RK21_RS05130	COG2223	nitrite transmembrane transporter activity
RK21_RS05195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RK21_RS05240	COG1192	Involved in chromosome partitioning
RK21_RS05265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK21_RS05270	COG0840	transmembrane signaling receptor activity
RK21_RS05300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK21_RS05305	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK21_RS05310	COG1177	transmembrane transport
RK21_RS05315	COG3842	ATPase activity
RK21_RS05330	COG2807	transmembrane transport
RK21_RS05415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RK21_RS05420	COG0765	amino acid transport
RK21_RS05425	COG0765	amino acid transport
RK21_RS05430	COG1126	abc transporter atp-binding protein
RK21_RS05435	COG3958	Transketolase
RK21_RS05440	COG3959	Transketolase, thiamine diphosphate binding domain
RK21_RS05445	COG2271	Major facilitator Superfamily
RK21_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS05455	COG0583	DNA-binding transcription factor activity
RK21_RS05475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RK21_RS05495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RK21_RS05500	COG1960	acyl-CoA dehydrogenase activity
RK21_RS05505	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS05515	COG0366	Alpha amylase catalytic
RK21_RS05520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RK21_RS05530	COG3568	Endonuclease Exonuclease Phosphatase
RK21_RS05550	COG1640	4-alpha-glucanotransferase
RK21_RS05555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RK21_RS05560	COG0297	glycogen (starch) synthase activity
RK21_RS05565	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RK21_RS05570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RK21_RS05575	COG3387	PFAM Glycoside hydrolase 15-related
RK21_RS05585	COG1309	transcriptional regulator
RK21_RS05595	COG0493	'glutamate synthase
RK21_RS05605	COG1953	Uracil, thiamine, allantoin
RK21_RS05615	COG1234	tRNA 3'-trailer cleavage
RK21_RS05620	COG3040	lipid binding
RK21_RS05630	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK21_RS05635	COG1024	Enoyl-CoA hydratase
RK21_RS05640	COG2816	NAD+ diphosphatase activity
RK21_RS05660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS05665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RK21_RS05670	COG2153	protein acetylation
RK21_RS05675	COG2850	peptidyl-arginine hydroxylation
RK21_RS05685	COG2915	High frequency lysogenization protein hflD homolog
RK21_RS05690	COG0482	sulfurtransferase activity
RK21_RS05710	COG1278	Cold shock
RK21_RS05715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RK21_RS05720	COG0542	response to heat
RK21_RS05725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RK21_RS05730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RK21_RS05735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RK21_RS05740	COG1674	ftsk spoiiie
RK21_RS05745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RK21_RS05750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RK21_RS05755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RK21_RS05760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RK21_RS05765	COG1648	precorrin-2 dehydrogenase activity
RK21_RS05765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RK21_RS05770	COG0435	Glutathione S-transferase
RK21_RS05775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RK21_RS05780	COG2920	part of a sulfur-relay system
RK21_RS05800	COG2233	PERMEase
RK21_RS05855	COG1063	alcohol dehydrogenase
RK21_RS05860	COG0583	DNA-binding transcription factor activity
RK21_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS05895	COG4447	cellulose binding
RK21_RS05910	COG1024	Enoyl-CoA hydratase
RK21_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS05925	COG1309	transcriptional regulator
RK21_RS05930	COG2124	cytochrome p450
RK21_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS05955	COG4221	oxidoreductase activity
RK21_RS05965	COG0633	Ferredoxin
RK21_RS05970	COG2223	nitrite transmembrane transporter activity
RK21_RS05990	COG0179	Fumarylacetoacetate (FAA) hydrolase
RK21_RS06015	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS06020	COG0179	Fumarylacetoacetate (FAA) hydrolase
RK21_RS06030	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
RK21_RS06060	COG0179	Fumarylacetoacetate (FAA) hydrolase
RK21_RS06065	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK21_RS06070	COG0183	Belongs to the thiolase family
RK21_RS06080	COG2124	cytochrome p450
RK21_RS06090	COG1960	acyl-CoA dehydrogenase activity
RK21_RS06095	COG1960	acyl-CoA dehydrogenase activity
RK21_RS06100	COG1024	Enoyl-CoA hydratase
RK21_RS06120	COG0386	Belongs to the glutathione peroxidase family
RK21_RS06125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RK21_RS06130	COG1309	transcriptional regulator
RK21_RS06150	COG2003	Belongs to the UPF0758 family
RK21_RS06210	COG1335	isochorismatase
RK21_RS06225	COG2199	diguanylate cyclase activity
RK21_RS06230	COG0471	metal ion transport
RK21_RS06230	COG0490	domain, Protein
RK21_RS06260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK21_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS06285	COG0616	signal peptide processing
RK21_RS06335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK21_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS06345	COG0583	DNA-binding transcription factor activity
RK21_RS06360	COG1064	alcohol dehydrogenase
RK21_RS06370	COG2259	Doxx family
RK21_RS06385	COG4191	Histidine kinase
RK21_RS06385	COG0784	Response regulator, receiver
RK21_RS06390	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RK21_RS06395	COG0745	RESPONSE REGULATOR receiver
RK21_RS06400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RK21_RS06410	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RK21_RS06440	COG2863	cytochrome
RK21_RS06445	COG3258	Cytochrome c
RK21_RS06470	COG3634	alkyl hydroperoxide reductase activity
RK21_RS06480	COG3132	Protein of unknown function, DUF480
RK21_RS06485	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RK21_RS06495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK21_RS06515	COG2207	Transcriptional regulator
RK21_RS06520	COG1064	alcohol dehydrogenase
RK21_RS06530	COG2814	Major facilitator Superfamily
RK21_RS06545	COG0583	DNA-binding transcription factor activity
RK21_RS06555	COG5642	Protein of unknown function (DUF2384)
RK21_RS06560	COG5654	RES domain protein
RK21_RS06565	COG1104	cysteine desulfurase activity
RK21_RS06580	COG0861	Integral membrane protein TerC family
RK21_RS06585	COG2885	chlorophyll binding
RK21_RS06590	COG3842	ATPase activity
RK21_RS06595	COG1177	transmembrane transport
RK21_RS06600	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK21_RS06610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK21_RS06620	COG1741	Belongs to the pirin family
RK21_RS06630	COG0583	DNA-binding transcription factor activity
RK21_RS06640	COG0446	pyridine nucleotide-disulphide oxidoreductase
RK21_RS06640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RK21_RS06655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RK21_RS06695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK21_RS06700	COG1121	(ABC) transporter
RK21_RS06740	COG1686	Belongs to the peptidase S11 family
RK21_RS06745	COG5002	protein histidine kinase activity
RK21_RS06785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK21_RS06820	COG5002	protein histidine kinase activity
RK21_RS06820	COG0784	Response regulator, receiver
RK21_RS06825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RK21_RS06835	COG2205	protein histidine kinase activity
RK21_RS06835	COG0784	Response regulator, receiver
RK21_RS06835	COG5002	protein histidine kinase activity
RK21_RS06840	COG2205	protein histidine kinase activity
RK21_RS06840	COG0784	Response regulator, receiver
RK21_RS06840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS06840	COG2198	Histidine kinase
RK21_RS06850	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK21_RS06855	COG0183	Belongs to the thiolase family
RK21_RS06865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK21_RS06870	COG0590	tRNA wobble adenosine to inosine editing
RK21_RS06875	COG2807	transmembrane transport
RK21_RS06895	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RK21_RS06900	COG0247	lactate metabolic process
RK21_RS06905	COG0277	FAD linked oxidase domain protein
RK21_RS06910	COG0277	FAD linked oxidase domain protein
RK21_RS06915	COG2186	Transcriptional regulator
RK21_RS06945	COG0768	penicillin binding
RK21_RS06960	COG0577	efflux transmembrane transporter activity
RK21_RS06970	COG1024	Enoyl-CoA hydratase
RK21_RS06995	COG0833	amino acid
RK21_RS07000	COG1024	Enoyl-CoA hydratase
RK21_RS07005	COG1960	acyl-CoA dehydrogenase activity
RK21_RS07010	COG0045	succinate-CoA ligase (ADP-forming) activity
RK21_RS07020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK21_RS07035	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK21_RS07055	COG3048	D-serine ammonia-lyase activity
RK21_RS07065	COG4948	Mandelate Racemase Muconate Lactonizing
RK21_RS07070	COG4829	muconolactone delta-isomerase
RK21_RS07075	COG3485	protocatechuate 3,4-dioxygenase
RK21_RS07085	COG5001	Diguanylate cyclase
RK21_RS07090	COG0656	L-ascorbic acid biosynthetic process
RK21_RS07110	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RK21_RS07115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK21_RS07130	COG3300	MHYT domain
RK21_RS07130	COG5001	Diguanylate cyclase
RK21_RS07135	COG1611	Belongs to the LOG family
RK21_RS07140	COG2855	membrane
RK21_RS07185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RK21_RS07190	COG2218	PFAM glutamate synthase alpha subunit domain protein
RK21_RS07195	COG0069	glutamate synthase activity
RK21_RS07200	COG0004	ammonium transporteR
RK21_RS07205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RK21_RS07220	COG1280	lysine exporter protein (LysE YggA)
RK21_RS07225	COG4191	Histidine kinase
RK21_RS07225	COG0784	Response regulator, receiver
RK21_RS07235	COG2186	Transcriptional regulator
RK21_RS07240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK21_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS07255	COG2267	carboxylic ester hydrolase activity
RK21_RS07265	COG3344	reverse transcriptase
RK21_RS07270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK21_RS07275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RK21_RS07280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RK21_RS07295	COG1959	2 iron, 2 sulfur cluster binding
RK21_RS07300	COG2207	Transcriptional regulator
RK21_RS07315	COG1116	anion transmembrane transporter activity
RK21_RS07320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK21_RS07325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK21_RS07335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RK21_RS07345	COG1942	4-Oxalocrotonate Tautomerase
RK21_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS07365	COG4991	sh3 domain protein
RK21_RS07375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK21_RS07405	COG2010	Cytochrome c
RK21_RS07420	COG1944	ATP diphosphatase activity
RK21_RS07475	COG2186	Transcriptional regulator
RK21_RS07480	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS07485	COG2721	sulfolactate sulfo-lyase activity
RK21_RS07490	COG2271	Major facilitator Superfamily
RK21_RS07495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK21_RS07500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RK21_RS07505	COG1126	abc transporter atp-binding protein
RK21_RS07510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS07545	COG0814	amino acid
RK21_RS07605	COG1595	DNA-templated transcription, initiation
RK21_RS07610	COG3712	iron ion homeostasis
RK21_RS07615	COG4774	siderophore transport
RK21_RS07625	COG2072	flavoprotein involved in K transport
RK21_RS07655	COG0583	DNA-binding transcription factor activity
RK21_RS07660	COG2814	Major facilitator Superfamily
RK21_RS07665	COG1280	lysine exporter protein (LysE YggA)
RK21_RS07695	COG4176	ABC-type proline glycine betaine transport system permease component
RK21_RS07705	COG0840	transmembrane signaling receptor activity
RK21_RS07710	COG2056	Na+-H+ antiporter family
RK21_RS07720	COG1960	acyl-CoA dehydrogenase activity
RK21_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS07730	COG4191	Histidine kinase
RK21_RS07735	COG4566	intracellular signal transduction
RK21_RS07745	COG1846	Transcriptional regulator
RK21_RS07750	COG1566	PFAM secretion protein HlyD family protein
RK21_RS07755	COG2814	Major facilitator Superfamily
RK21_RS07770	COG1477	protein flavinylation
RK21_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS07780	COG0784	Response regulator, receiver
RK21_RS07780	COG4191	Histidine kinase
RK21_RS07790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS07795	COG0348	domain, Protein
RK21_RS07805	COG1285	pathogenesis
RK21_RS07815	COG0789	Transcriptional regulator
RK21_RS07825	COG2207	Transcriptional regulator
RK21_RS07840	COG0405	Gamma-glutamyltransferase
RK21_RS07845	COG0583	DNA-binding transcription factor activity
RK21_RS07855	COG3257	ureidoglycine aminohydrolase activity
RK21_RS07865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK21_RS07870	COG1309	transcriptional regulator
RK21_RS07875	COG0708	Exodeoxyribonuclease III
RK21_RS07885	COG0729	surface antigen
RK21_RS07925	COG2366	antibiotic biosynthetic process
RK21_RS07930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK21_RS07940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK21_RS07945	COG0215	cysteine-tRNA ligase activity
RK21_RS07950	COG5002	protein histidine kinase activity
RK21_RS07950	COG3850	Histidine kinase
RK21_RS07955	COG0745	RESPONSE REGULATOR receiver
RK21_RS07960	COG1802	Transcriptional regulator
RK21_RS07970	COG0579	oxidoreductase
RK21_RS07975	COG1113	amino acid transport
RK21_RS07985	COG0113	porphobilinogen synthase activity
RK21_RS08000	COG0307	riboflavin synthase, alpha
RK21_RS08020	COG0579	oxidoreductase
RK21_RS08035	COG0583	DNA-binding transcription factor activity
RK21_RS08050	COG0019	diaminopimelate decarboxylase activity
RK21_RS08055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RK21_RS08070	COG0826	peptidase U32
RK21_RS08080	COG2384	SAM-dependent methyltransferase
RK21_RS08090	COG0583	DNA-binding transcription factor activity
RK21_RS08100	COG1960	acyl-CoA dehydrogenase activity
RK21_RS08120	COG3052	prosthetic group binding
RK21_RS08190	COG2204	response regulator
RK21_RS08195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK21_RS08225	COG2165	general secretion pathway protein
RK21_RS08230	COG2165	general secretion pathway protein
RK21_RS08265	COG3284	Transcriptional regulator
RK21_RS08270	COG1132	(ABC) transporter
RK21_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS08315	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS08320	COG0746	molybdenum cofactor guanylyltransferase activity
RK21_RS08330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS08335	COG0745	RESPONSE REGULATOR receiver
RK21_RS08340	COG2205	protein histidine kinase activity
RK21_RS08345	COG5001	Diguanylate cyclase
RK21_RS08360	COG1215	transferase activity, transferring glycosyl groups
RK21_RS08370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RK21_RS08415	COG1253	flavin adenine dinucleotide binding
RK21_RS08425	COG2200	EAL domain
RK21_RS08445	COG0784	Response regulator, receiver
RK21_RS08445	COG4191	Histidine kinase
RK21_RS08470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS08475	COG1459	type II secretion system
RK21_RS08485	COG1196	nuclear chromosome segregation
RK21_RS08485	COG0741	lytic transglycosylase activity
RK21_RS08485	COG0739	heme binding
RK21_RS08490	COG5002	protein histidine kinase activity
RK21_RS08500	COG2204	response regulator
RK21_RS08515	COG3265	gluconokinase activity
RK21_RS08520	COG1609	Transcriptional regulator
RK21_RS08530	COG2205	protein histidine kinase activity
RK21_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS08535	COG2197	response regulator
RK21_RS08540	COG3813	Protein conserved in bacteria
RK21_RS08650	COG1609	Transcriptional regulator
RK21_RS08660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK21_RS08795	COG2369	cell adhesion
RK21_RS08835	COG3209	COG3209 Rhs family protein
RK21_RS08860	COG1473	amidohydrolase
RK21_RS08870	COG0154	amidase activity
RK21_RS08875	COG1414	Transcriptional regulator
RK21_RS08885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK21_RS08890	COG0583	DNA-binding transcription factor activity
RK21_RS08895	COG1280	lysine exporter protein (LysE YggA)
RK21_RS08900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RK21_RS08915	COG0587	DNA-directed DNA polymerase activity
RK21_RS08920	COG0656	L-ascorbic acid biosynthetic process
RK21_RS08930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RK21_RS08940	COG2031	fatty acid transporter
RK21_RS08945	COG1396	sequence-specific DNA binding
RK21_RS08970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RK21_RS09005	COG1045	serine acetyltransferase
RK21_RS09010	COG1215	transferase activity, transferring glycosyl groups
RK21_RS09015	COG2990	Protein conserved in bacteria
RK21_RS09020	COG0438	transferase activity, transferring glycosyl groups
RK21_RS09035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK21_RS09040	COG0583	DNA-binding transcription factor activity
RK21_RS09045	COG1760	l-serine dehydratase
RK21_RS09055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS09065	COG0174	glutamine synthetase
RK21_RS09080	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS09085	COG0583	DNA-binding transcription factor activity
RK21_RS09155	COG2814	Major facilitator Superfamily
RK21_RS09160	COG3485	protocatechuate 3,4-dioxygenase
RK21_RS09165	COG3135	benzoate transporter
RK21_RS09190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK21_RS09195	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS09205	COG0667	Aldo Keto reductase
RK21_RS09210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK21_RS09215	COG2271	Major facilitator Superfamily
RK21_RS09220	COG3835	regulator
RK21_RS09225	COG1929	Belongs to the glycerate kinase type-1 family
RK21_RS09245	COG1999	signal sequence binding
RK21_RS09260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RK21_RS09265	COG0402	S-adenosylhomocysteine deaminase activity
RK21_RS09285	COG2203	Gaf domain
RK21_RS09285	COG3706	GGDEF domain
RK21_RS09285	COG4251	negative regulation of phosphorylation
RK21_RS09285	COG5001	Diguanylate cyclase
RK21_RS09305	COG0385	Bile acid
RK21_RS09310	COG2837	iron assimilation
RK21_RS09315	COG0667	Aldo Keto reductase
RK21_RS09340	COG2890	protein-(glutamine-N5) methyltransferase activity
RK21_RS09345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RK21_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS09380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RK21_RS09410	COG0392	lysyltransferase activity
RK21_RS09415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK21_RS09420	COG3568	Endonuclease Exonuclease Phosphatase
RK21_RS09440	COG0494	nUDIX hydrolase
RK21_RS09460	COG2030	dehydratase
RK21_RS09460	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS09475	COG3162	membrane
RK21_RS09480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK21_RS09485	COG2151	metal-sulfur cluster biosynthetic enzyme
RK21_RS09490	COG3396	Phenylacetate-CoA oxygenase
RK21_RS09495	COG3460	Phenylacetate-CoA oxygenase
RK21_RS09500	COG3396	Phenylacetate-CoA oxygenase
RK21_RS09510	COG0183	Belongs to the thiolase family
RK21_RS09515	COG2050	protein possibly involved in aromatic compounds catabolism
RK21_RS09520	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK21_RS09525	COG1024	Enoyl-CoA hydratase
RK21_RS09530	COG1024	Enoyl-CoA hydratase
RK21_RS09540	COG3327	negative regulation of DNA-templated transcription, initiation
RK21_RS09625	COG2801	Transposase and inactivated derivatives
RK21_RS09630	COG2963	transposase activity
RK21_RS09640	COG0583	DNA-binding transcription factor activity
RK21_RS09645	COG0747	negative chemotaxis
RK21_RS09665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK21_RS09705	COG0659	secondary active sulfate transmembrane transporter activity
RK21_RS09710	COG0589	response to stress
RK21_RS09720	COG2433	Pfam Transposase IS66
RK21_RS09775	COG2323	membrane
RK21_RS09785	COG1058	Belongs to the CinA family
RK21_RS09785	COG1546	Belongs to the CinA family
RK21_RS09790	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS09855	COG1063	alcohol dehydrogenase
RK21_RS09870	COG3685	Protein conserved in bacteria
RK21_RS09875	COG3546	catalase activity
RK21_RS09885	COG3685	Protein conserved in bacteria
RK21_RS09915	COG2323	membrane
RK21_RS10010	COG2963	transposase activity
RK21_RS10015	COG2801	Transposase and inactivated derivatives
RK21_RS10050	COG3012	SEC-C Motif Domain Protein
RK21_RS10055	COG2801	Transposase and inactivated derivatives
RK21_RS10095	COG1522	sequence-specific DNA binding
RK21_RS10125	COG4977	sequence-specific DNA binding
RK21_RS10130	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS10135	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
RK21_RS10145	COG0583	DNA-binding transcription factor activity
RK21_RS10195	COG0028	Belongs to the TPP enzyme family
RK21_RS10210	COG0583	DNA-binding transcription factor activity
RK21_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS10220	COG0678	peroxiredoxin activity
RK21_RS10240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RK21_RS10245	COG2197	response regulator
RK21_RS10255	COG0531	amino acid
RK21_RS10270	COG2814	Major facilitator Superfamily
RK21_RS10275	COG2356	endonuclease I
RK21_RS10285	COG1881	PFAM PEBP family protein
RK21_RS10290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK21_RS10295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK21_RS10300	COG4166	transmembrane transport
RK21_RS10305	COG4174	ABC transporter (Permease)
RK21_RS10310	COG4239	(ABC) transporter, permease
RK21_RS10315	COG3290	protein histidine kinase activity
RK21_RS10315	COG3829	transcription factor binding
RK21_RS10320	COG2610	gluconate transmembrane transporter activity
RK21_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS10330	COG4574	serine-type endopeptidase inhibitor activity
RK21_RS10335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK21_RS10340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK21_RS10365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RK21_RS10385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RK21_RS10390	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS10395	COG1960	acyl-CoA dehydrogenase activity
RK21_RS10430	COG2855	membrane
RK21_RS10445	COG2814	Major facilitator Superfamily
RK21_RS10450	COG3246	L-lysine catabolic process to acetate
RK21_RS10455	COG2175	clavaminate synthase activity
RK21_RS10485	COG1301	dicarboxylic acid transport
RK21_RS10515	COG1858	cytochrome C peroxidase
RK21_RS10525	COG2135	peptidase activity
RK21_RS10545	COG2135	peptidase activity
RK21_RS10550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RK21_RS10615	COG3846	protein secretion by the type IV secretion system
RK21_RS10630	COG3451	type IV secretory pathway VirB4
RK21_RS10640	COG3838	Conjugal transfer protein Trbc
RK21_RS10645	COG4962	Type ii secretion system protein e
RK21_RS10665	COG0583	DNA-binding transcription factor activity
RK21_RS10670	COG1522	sequence-specific DNA binding
RK21_RS10685	COG0633	Ferredoxin
RK21_RS10690	COG0789	Transcriptional regulator
RK21_RS10700	COG0640	Transcriptional regulator
RK21_RS10705	COG2814	Major facilitator Superfamily
RK21_RS10710	COG1937	Protein conserved in bacteria
RK21_RS10715	COG1230	cation diffusion facilitator family transporter
RK21_RS10720	COG0640	Transcriptional regulator
RK21_RS10745	COG2814	Major facilitator Superfamily
RK21_RS10755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RK21_RS10780	COG1192	Involved in chromosome partitioning
RK21_RS10810	COG5489	Protein of unknown function (DUF736)
RK21_RS10835	COG1475	DNA binding
RK21_RS10855	COG4804	nuclease activity
RK21_RS10930	COG0740	serine-type endopeptidase activity
RK21_RS10935	COG4695	Portal protein
RK21_RS10980	COG0582	viral genome integration into host DNA
RK21_RS11070	COG5532	Uncharacterized conserved protein (DUF2303)
RK21_RS11170	COG0488	(ABC) transporter
RK21_RS11185	COG0625	glutathione transferase activity
RK21_RS11190	COG2204	response regulator
RK21_RS11225	COG0488	(ABC) transporter
RK21_RS11230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RK21_RS11240	COG0583	DNA-binding transcription factor activity
RK21_RS11260	COG3064	Membrane
RK21_RS11315	COG1595	DNA-templated transcription, initiation
RK21_RS11325	COG3038	cytochrome b561
RK21_RS11335	COG1917	Cupin 2, conserved barrel domain protein
RK21_RS11335	COG1396	sequence-specific DNA binding
RK21_RS11345	COG4221	oxidoreductase activity
RK21_RS11385	COG0393	Putative heavy-metal-binding
RK21_RS11395	COG0235	Class ii aldolase
RK21_RS11405	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS11405	COG0446	pyridine nucleotide-disulphide oxidoreductase
RK21_RS11415	COG1252	NADH dehydrogenase
RK21_RS11420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RK21_RS11440	COG1968	undecaprenyl-diphosphatase activity
RK21_RS11445	COG0840	transmembrane signaling receptor activity
RK21_RS11500	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RK21_RS11505	COG0830	nickel cation binding
RK21_RS11515	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RK21_RS11520	COG0804	urea catabolic process
RK21_RS11525	COG0832	Belongs to the urease beta subunit family
RK21_RS11530	COG0831	urea catabolic process
RK21_RS11535	COG0829	nickel cation binding
RK21_RS11540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RK21_RS11550	COG1199	ATP-dependent helicase activity
RK21_RS11550	COG1199	ATP-dependent helicase activity
RK21_RS11560	COG2271	Major facilitator Superfamily
RK21_RS11575	COG2721	sulfolactate sulfo-lyase activity
RK21_RS11580	COG0583	DNA-binding transcription factor activity
RK21_RS11590	COG4948	Mandelate Racemase Muconate Lactonizing
RK21_RS11600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS11610	COG0604	alcohol dehydrogenase
RK21_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS11610	COG3321	synthase
RK21_RS11635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK21_RS11655	COG1113	amino acid transport
RK21_RS11675	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS11680	COG0010	Belongs to the arginase family
RK21_RS11690	COG0583	DNA-binding transcription factor activity
RK21_RS11695	COG0814	amino acid
RK21_RS11700	COG0626	cystathionine gamma-synthase activity
RK21_RS11705	COG2860	membrane
RK21_RS11710	COG3039	Transposase
RK21_RS11720	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK21_RS11765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK21_RS11775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK21_RS11780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RK21_RS11785	COG0038	chloride channel
RK21_RS11790	COG0583	DNA-binding transcription factor activity
RK21_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS11820	COG0531	amino acid
RK21_RS11830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RK21_RS11840	COG0589	response to stress
RK21_RS11855	COG0589	response to stress
RK21_RS11860	COG0459	protein refolding
RK21_RS11865	COG2217	Heavy metal translocating P-type atpase
RK21_RS11875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RK21_RS11885	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RK21_RS11895	COG0071	Belongs to the small heat shock protein (HSP20) family
RK21_RS11935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RK21_RS11960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK21_RS11970	COG0668	transmembrane transport
RK21_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS11985	COG2986	histidine ammonia-lyase
RK21_RS11990	COG0517	IMP dehydrogenase activity
RK21_RS11990	COG4175	Glycine betaine
RK21_RS11995	COG4176	ABC-type proline glycine betaine transport system permease component
RK21_RS12010	COG3300	MHYT domain
RK21_RS12010	COG5001	Diguanylate cyclase
RK21_RS12025	COG1082	Xylose isomerase domain protein TIM barrel
RK21_RS12030	COG2271	Major facilitator Superfamily
RK21_RS12035	COG2308	Evidence 4 Homologs of previously reported genes of
RK21_RS12045	COG1305	Transglutaminase-like
RK21_RS12055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK21_RS12060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RK21_RS12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS12095	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
RK21_RS12105	COG0583	DNA-binding transcription factor activity
RK21_RS12180	COG1090	epimerase
RK21_RS12185	COG5001	Diguanylate cyclase
RK21_RS12185	COG4251	negative regulation of phosphorylation
RK21_RS12185	COG3706	GGDEF domain
RK21_RS12185	COG2203	Gaf domain
RK21_RS12200	COG2851	Citrate transporter
RK21_RS12205	COG1301	dicarboxylic acid transport
RK21_RS12210	COG2828	Protein conserved in bacteria
RK21_RS12215	COG0583	DNA-binding transcription factor activity
RK21_RS12235	COG0640	Transcriptional regulator
RK21_RS12240	COG0798	PFAM Bile acid sodium symporter
RK21_RS12245	COG0431	NADPH-dependent FMN reductase
RK21_RS12250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK21_RS12260	COG3321	synthase
RK21_RS12260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RK21_RS12260	COG0604	alcohol dehydrogenase
RK21_RS12260	COG4221	oxidoreductase activity
RK21_RS12265	COG0583	DNA-binding transcription factor activity
RK21_RS12270	COG0583	DNA-binding transcription factor activity
RK21_RS12330	COG1063	alcohol dehydrogenase
RK21_RS12340	COG1546	Belongs to the CinA family
RK21_RS12340	COG1058	Belongs to the CinA family
RK21_RS12350	COG2323	membrane
RK21_RS12365	COG0668	transmembrane transport
RK21_RS12395	COG2116	formate transmembrane transporter activity
RK21_RS12400	COG1802	Transcriptional regulator
RK21_RS12405	COG1172	Belongs to the binding-protein-dependent transport system permease family
RK21_RS12410	COG1129	ABC transporter
RK21_RS12420	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS12430	COG1454	alcohol dehydrogenase
RK21_RS12440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK21_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS12450	COG0371	Dehydrogenase
RK21_RS12455	COG3959	Transketolase, thiamine diphosphate binding domain
RK21_RS12460	COG3958	Transketolase
RK21_RS12465	COG0477	Major facilitator Superfamily
RK21_RS12470	COG1538	Outer membrane efflux protein
RK21_RS12480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS12485	COG0659	secondary active sulfate transmembrane transporter activity
RK21_RS12490	COG4191	Histidine kinase
RK21_RS12550	COG4585	Histidine kinase
RK21_RS12565	COG1131	(ABC) transporter
RK21_RS12585	COG0784	Response regulator, receiver
RK21_RS12585	COG2205	protein histidine kinase activity
RK21_RS12600	COG0789	Transcriptional regulator
RK21_RS12605	COG1366	Belongs to the anti-sigma-factor antagonist family
RK21_RS12605	COG2202	Pas domain
RK21_RS12615	COG4221	oxidoreductase activity
RK21_RS12630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RK21_RS12640	COG3046	protein related to deoxyribodipyrimidine photolyase
RK21_RS12665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RK21_RS12670	COG0174	glutamine synthetase
RK21_RS12690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK21_RS12695	COG0581	inorganic phosphate transmembrane transporter activity
RK21_RS12705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RK21_RS12730	COG3158	transport of potassium into the cell
RK21_RS12760	COG3217	Mosc domain protein beta barrel domain protein
RK21_RS12760	COG0633	Ferredoxin
RK21_RS12765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK21_RS12800	COG1984	allophanate hydrolase subunit 2
RK21_RS12810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RK21_RS12820	COG1132	(ABC) transporter
RK21_RS12825	COG1414	Transcriptional regulator
RK21_RS12830	COG3842	ATPase activity
RK21_RS12835	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK21_RS12840	COG1177	transmembrane transport
RK21_RS12865	COG1414	Transcriptional regulator
RK21_RS12870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK21_RS12875	COG1053	succinate dehydrogenase
RK21_RS12885	COG1053	succinate dehydrogenase
RK21_RS12900	COG0673	inositol 2-dehydrogenase activity
RK21_RS12910	COG1053	succinate dehydrogenase
RK21_RS12915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RK21_RS12920	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS12930	COG2197	response regulator
RK21_RS12935	COG0531	amino acid
RK21_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS12960	COG2194	sulfuric ester hydrolase activity
RK21_RS12970	COG3008	intermembrane lipid transfer
RK21_RS12975	COG2995	paraquat-inducible protein a
RK21_RS13000	COG0346	lactoylglutathione lyase activity
RK21_RS13020	COG0300	oxidoreductase activity
RK21_RS13050	COG0477	Major facilitator Superfamily
RK21_RS13055	COG0596	Alpha beta hydrolase
RK21_RS13065	COG0596	Alpha beta hydrolase
RK21_RS13075	COG0210	DNA helicase
RK21_RS13090	COG0583	DNA-binding transcription factor activity
RK21_RS13095	COG1301	dicarboxylic acid transport
RK21_RS13105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RK21_RS13130	COG3300	MHYT domain
RK21_RS13130	COG5001	Diguanylate cyclase
RK21_RS13145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
RK21_RS13145	COG1082	Xylose isomerase domain protein TIM barrel
RK21_RS13150	COG0477	Major facilitator Superfamily
RK21_RS13155	COG0076	glutamate decarboxylase activity
RK21_RS13160	COG0583	DNA-binding transcription factor activity
RK21_RS13165	COG0217	transcriptional regulatory protein
RK21_RS13170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS13180	COG0583	DNA-binding transcription factor activity
RK21_RS13190	COG4106	trans-aconitate 2-methyltransferase activity
RK21_RS13200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS13225	COG0583	DNA-binding transcription factor activity
RK21_RS13235	COG2026	Addiction module toxin, RelE StbE family
RK21_RS13245	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS13250	COG2814	Major facilitator Superfamily
RK21_RS13255	COG1063	alcohol dehydrogenase
RK21_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS13280	COG2271	Major facilitator Superfamily
RK21_RS13300	COG0625	glutathione transferase activity
RK21_RS13305	COG2814	Major facilitator Superfamily
RK21_RS13310	COG0583	DNA-binding transcription factor activity
RK21_RS13330	COG4977	sequence-specific DNA binding
RK21_RS13345	COG2873	o-acetylhomoserine
RK21_RS13380	COG2066	Belongs to the glutaminase family
RK21_RS13385	COG2066	Belongs to the glutaminase family
RK21_RS13410	COG1418	mRNA catabolic process
RK21_RS13425	COG2826	transposase and inactivated derivatives, IS30 family
RK21_RS13435	COG0582	viral genome integration into host DNA
RK21_RS13590	COG3384	dioxygenase
RK21_RS13600	COG0583	DNA-binding transcription factor activity
RK21_RS13645	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK21_RS13650	COG1024	Enoyl-CoA hydratase
RK21_RS13660	COG1960	acyl-CoA dehydrogenase activity
RK21_RS13665	COG2814	Major facilitator Superfamily
RK21_RS13715	COG2130	NADP-dependent
RK21_RS13770	COG0411	ABC transporter
RK21_RS13785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK21_RS13790	COG0579	oxidoreductase
RK21_RS13800	COG1802	Transcriptional regulator
RK21_RS13815	COG3344	reverse transcriptase
RK21_RS13850	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK21_RS13855	COG1024	Enoyl-CoA hydratase
RK21_RS13865	COG1960	acyl-CoA dehydrogenase activity
RK21_RS13875	COG1942	4-Oxalocrotonate Tautomerase
RK21_RS13880	COG0583	DNA-binding transcription factor activity
RK21_RS13885	COG1309	transcriptional regulator
RK21_RS13895	COG3039	Transposase
RK21_RS13965	COG3436	PFAM IS66 Orf2 family protein
RK21_RS14030	COG0776	regulation of translation
RK21_RS14035	COG0072	phenylalanine-tRNA ligase activity
RK21_RS14040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RK21_RS14045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RK21_RS14050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RK21_RS14055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RK21_RS14060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RK21_RS14070	COG1278	Cold shock
RK21_RS14080	COG4804	nuclease activity
RK21_RS14085	COG2003	Belongs to the UPF0758 family
RK21_RS14090	COG0431	NADPH-dependent FMN reductase
RK21_RS14100	COG0798	PFAM Bile acid sodium symporter
RK21_RS14125	COG0640	Transcriptional regulator
RK21_RS14155	COG5489	Protein of unknown function (DUF736)
RK21_RS14185	COG1192	Involved in chromosome partitioning
RK21_RS14200	COG4959	Type IV secretory pathway protease TraF
RK21_RS14275	COG4962	Type ii secretion system protein e
RK21_RS14280	COG3838	Conjugal transfer protein Trbc
RK21_RS14290	COG3451	type IV secretory pathway VirB4
RK21_RS14305	COG3846	protein secretion by the type IV secretion system
RK21_RS14315	COG3504	Conjugal transfer protein
RK21_RS14345	COG1869	D-ribose catabolic process
RK21_RS14350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK21_RS14355	COG1609	Transcriptional regulator
RK21_RS14360	COG1172	Belongs to the binding-protein-dependent transport system permease family
RK21_RS14365	COG1129	ABC transporter
RK21_RS14370	COG1879	ABC-type sugar transport system periplasmic component
RK21_RS14375	COG0252	asparaginase activity
RK21_RS14385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK21_RS14405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS14415	COG1253	flavin adenine dinucleotide binding
RK21_RS14425	COG0583	DNA-binding transcription factor activity
RK21_RS14430	COG4774	siderophore transport
RK21_RS14445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK21_RS14450	COG1120	ATPase activity
RK21_RS14470	COG1192	Involved in chromosome partitioning
RK21_RS14480	COG4774	siderophore transport
RK21_RS14505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RK21_RS14510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK21_RS14540	COG2259	Doxx family
RK21_RS14550	COG3220	belongs to the UPF0276 family
RK21_RS14570	COG0417	DNA replication proofreading
RK21_RS14575	COG0583	DNA-binding transcription factor activity
RK21_RS14625	COG1999	signal sequence binding
RK21_RS14630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RK21_RS14630	COG0316	Belongs to the HesB IscA family
RK21_RS14635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RK21_RS14660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK21_RS14685	COG2205	protein histidine kinase activity
RK21_RS14695	COG2853	Lipoprotein
RK21_RS14705	COG2223	nitrite transmembrane transporter activity
RK21_RS14710	COG2207	Transcriptional regulator
RK21_RS14715	COG2866	Carboxypeptidase
RK21_RS14755	COG4251	negative regulation of phosphorylation
RK21_RS14760	COG0745	RESPONSE REGULATOR receiver
RK21_RS14785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RK21_RS14800	COG0517	IMP dehydrogenase activity
RK21_RS14830	COG0720	synthase
RK21_RS14845	COG2079	MmgE PrpD family protein
RK21_RS14860	COG0372	Belongs to the citrate synthase family
RK21_RS14870	COG1802	Transcriptional regulator
RK21_RS14875	COG4067	protein conserved in archaea
RK21_RS14875	COG0189	ligase activity
RK21_RS14905	COG0589	response to stress
RK21_RS14910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RK21_RS14915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK21_RS14930	COG1376	ErfK ybiS ycfS ynhG family protein
RK21_RS14930	COG1388	LysM domain
RK21_RS14945	COG4181	ATPase activity
RK21_RS14950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RK21_RS14955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK21_RS14965	COG2259	Doxx family
RK21_RS14970	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RK21_RS15010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK21_RS15020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RK21_RS15025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RK21_RS15030	COG0740	serine-type endopeptidase activity
RK21_RS15035	COG0544	peptidyl-prolyl cis-trans isomerase activity
RK21_RS15065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RK21_RS15080	COG0395	ABC-type sugar transport system, permease component
RK21_RS15090	COG3842	ATPase activity
RK21_RS15095	COG3842	ATPase activity
RK21_RS15100	COG3284	Transcriptional regulator
RK21_RS15105	COG2423	ornithine cyclodeaminase activity
RK21_RS15120	COG0840	transmembrane signaling receptor activity
RK21_RS15135	COG2186	Transcriptional regulator
RK21_RS15155	COG0583	DNA-binding transcription factor activity
RK21_RS15160	COG0840	transmembrane signaling receptor activity
RK21_RS15165	COG3949	Membrane
RK21_RS15170	COG0251	oxidation-reduction process
RK21_RS15185	COG0730	response to heat
RK21_RS15205	COG4178	(ABC) transporter
RK21_RS15260	COG1335	isochorismatase
RK21_RS15275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RK21_RS15275	COG2111	Na H antiporter
RK21_RS15280	COG1006	Multisubunit Na H antiporter MnhC subunit
RK21_RS15285	COG0651	ATP synthesis coupled electron transport
RK21_RS15295	COG2212	antiporter activity
RK21_RS15300	COG1320	monovalent cation:proton antiporter activity
RK21_RS15330	COG1024	Enoyl-CoA hydratase
RK21_RS15335	COG1960	acyl-CoA dehydrogenase activity
RK21_RS15340	COG0183	Belongs to the thiolase family
RK21_RS15350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK21_RS15370	COG0583	DNA-binding transcription factor activity
RK21_RS15375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RK21_RS15380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK21_RS15390	COG0826	peptidase U32
RK21_RS15405	COG1238	metal cluster binding
RK21_RS15410	COG0596	Alpha beta hydrolase
RK21_RS15420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RK21_RS15425	COG2133	pyrroloquinoline quinone binding
RK21_RS15435	COG0010	Belongs to the arginase family
RK21_RS15455	COG1595	DNA-templated transcription, initiation
RK21_RS15480	COG0589	response to stress
RK21_RS15490	COG3383	formate dehydrogenase (NAD+) activity
RK21_RS15550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK21_RS15555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RK21_RS15570	COG4566	intracellular signal transduction
RK21_RS15580	COG2853	Lipoprotein
RK21_RS15595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RK21_RS15595	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RK21_RS15610	COG4591	ABC-type transport system involved in lipoprotein release permease component
RK21_RS15615	COG1136	(ABC) transporter
RK21_RS15620	COG4591	ABC-type transport system involved in lipoprotein release permease component
RK21_RS15630	COG0584	glycerophosphoryl diester phosphodiesterase
RK21_RS15635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK21_RS15640	COG1477	protein flavinylation
RK21_RS15650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RK21_RS15660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RK21_RS15675	COG1376	ErfK ybiS ycfS ynhG family protein
RK21_RS15685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RK21_RS15715	COG0183	Belongs to the thiolase family
RK21_RS15730	COG0589	response to stress
RK21_RS15735	COG0488	(ABC) transporter
RK21_RS15740	COG0741	lytic transglycosylase activity
RK21_RS15750	COG0784	Response regulator, receiver
RK21_RS15750	COG0835	chemotaxis
RK21_RS15765	COG3851	Histidine kinase
RK21_RS15770	COG2197	response regulator
RK21_RS15775	COG1597	lipid kinase activity
RK21_RS15790	COG0521	Mo-molybdopterin cofactor biosynthetic process
RK21_RS15815	COG1132	(ABC) transporter
RK21_RS15820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK21_RS15825	COG0425	Belongs to the sulfur carrier protein TusA family
RK21_RS15835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
RK21_RS15850	COG0840	transmembrane signaling receptor activity
RK21_RS15855	COG0564	pseudouridine synthase activity
RK21_RS15875	COG0004	ammonium transporteR
RK21_RS15900	COG2197	response regulator
RK21_RS15905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS15905	COG2205	protein histidine kinase activity
RK21_RS15910	COG3171	Protein conserved in bacteria
RK21_RS15915	COG2027	D-alanyl-D-alanine carboxypeptidase
RK21_RS15925	COG0116	Belongs to the methyltransferase superfamily
RK21_RS15925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK21_RS15930	COG0167	dihydroorotate dehydrogenase activity
RK21_RS15935	COG1116	anion transmembrane transporter activity
RK21_RS15935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK21_RS15940	COG3707	response regulator
RK21_RS15945	COG2223	nitrite transmembrane transporter activity
RK21_RS15970	COG0668	transmembrane transport
RK21_RS15985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RK21_RS16000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RK21_RS16005	COG3344	reverse transcriptase
RK21_RS16020	COG0583	DNA-binding transcription factor activity
RK21_RS16025	COG0019	diaminopimelate decarboxylase activity
RK21_RS16040	COG2188	Transcriptional regulator
RK21_RS16045	COG0789	Transcriptional regulator
RK21_RS16055	COG2814	Major facilitator Superfamily
RK21_RS16085	COG0183	Belongs to the thiolase family
RK21_RS16095	COG1454	alcohol dehydrogenase
RK21_RS16100	COG1960	acyl-CoA dehydrogenase activity
RK21_RS16115	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RK21_RS16125	COG2149	membrane
RK21_RS16150	COG1960	acyl-CoA dehydrogenase activity
RK21_RS16155	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS16165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK21_RS16175	COG3135	benzoate transporter
RK21_RS16190	COG0714	Associated with various cellular activities
RK21_RS16265	COG3209	COG3209 Rhs family protein
RK21_RS16270	COG0420	3'-5' exonuclease activity
RK21_RS16290	COG2706	6-phosphogluconolactonase activity
RK21_RS16310	COG0308	aminopeptidase N
RK21_RS16320	COG3139	Protein of unknown function (DUF1315)
RK21_RS16325	COG0705	Rhomboid family
RK21_RS16330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RK21_RS16335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RK21_RS16345	COG3038	cytochrome b561
RK21_RS16355	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS16355	COG0446	pyridine nucleotide-disulphide oxidoreductase
RK21_RS16370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS16375	COG0697	spore germination
RK21_RS16420	COG1286	toxin biosynthetic process
RK21_RS16430	COG0285	dihydrofolate synthase activity
RK21_RS16435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RK21_RS16440	COG0135	phosphoribosylanthranilate isomerase activity
RK21_RS16470	COG0473	3-isopropylmalate dehydrogenase activity
RK21_RS16475	COG2226	methyltransferase
RK21_RS16480	COG0066	3-isopropylmalate dehydratase activity
RK21_RS16485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RK21_RS16505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK21_RS16560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK21_RS16575	COG0556	nucleotide-excision repair
RK21_RS16610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RK21_RS16620	COG0084	hydrolase, TatD family'
RK21_RS16630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RK21_RS16635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RK21_RS16645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK21_RS16650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RK21_RS16660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RK21_RS16665	COG0416	fatty acid biosynthetic process
RK21_RS16670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RK21_RS16680	COG0424	maF-like protein
RK21_RS16685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK21_RS16685	COG0616	signal peptide processing
RK21_RS16690	COG0546	phosphoglycolate phosphatase activity
RK21_RS16700	COG1530	ribonuclease E activity
RK21_RS16705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RK21_RS16710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RK21_RS16715	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RK21_RS16720	COG2835	tetraacyldisaccharide 4'-kinase activity
RK21_RS16725	COG1663	tetraacyldisaccharide 4'-kinase activity
RK21_RS16730	COG0848	biopolymer transport protein
RK21_RS16735	COG0811	peptide transport
RK21_RS16740	COG0658	competence protein
RK21_RS16740	COG2333	competence protein COMEC
RK21_RS16745	COG0842	Transport permease protein
RK21_RS16750	COG1131	(ABC) transporter
RK21_RS16755	COG0625	glutathione transferase activity
RK21_RS16760	COG1960	acyl-CoA dehydrogenase activity
RK21_RS16775	COG3121	Chaperone
RK21_RS16795	COG3328	transposase activity
RK21_RS16800	COG3188	usher protein
RK21_RS16840	COG1956	GAF domain-containing protein
RK21_RS16850	COG3437	response regulator, receiver
RK21_RS16850	COG2205	protein histidine kinase activity
RK21_RS16850	COG3850	Histidine kinase
RK21_RS16850	COG4999	Histidine kinase
RK21_RS16855	COG0386	Belongs to the glutathione peroxidase family
RK21_RS16860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK21_RS16865	COG0436	Aminotransferase
RK21_RS16870	COG0501	Belongs to the peptidase M48B family
RK21_RS16875	COG0500	methyltransferase
RK21_RS16880	COG3384	dioxygenase
RK21_RS16895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RK21_RS16905	COG0583	DNA-binding transcription factor activity
RK21_RS16915	COG0583	DNA-binding transcription factor activity
RK21_RS16920	COG1846	Transcriptional regulator
RK21_RS16925	COG1764	response to oxidative stress
RK21_RS16930	COG3385	transposase activity
RK21_RS16935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RK21_RS16955	COG0583	DNA-binding transcription factor activity
RK21_RS16960	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS16965	COG2814	Major facilitator Superfamily
RK21_RS16975	COG4773	Receptor
RK21_RS16990	COG0204	Acyl-transferase
RK21_RS16995	COG0598	Magnesium transport protein CorA
RK21_RS17000	COG0519	Catalyzes the synthesis of GMP from XMP
RK21_RS17020	COG1368	sulfuric ester hydrolase activity
RK21_RS17050	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
RK21_RS17055	COG2814	Major facilitator Superfamily
RK21_RS17060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RK21_RS17090	COG2840	Smr protein MutS2
RK21_RS17095	COG0302	gtp cyclohydrolase
RK21_RS17105	COG0625	glutathione transferase activity
RK21_RS17110	COG3135	benzoate transporter
RK21_RS17115	COG0840	transmembrane signaling receptor activity
RK21_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS17125	COG2130	NADP-dependent
RK21_RS17130	COG5654	RES domain protein
RK21_RS17140	COG0284	orotidine-5'-phosphate decarboxylase activity
RK21_RS17145	COG1555	photosystem II stabilization
RK21_RS17150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RK21_RS17155	COG0166	Belongs to the GPI family
RK21_RS17180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RK21_RS17220	COG1216	Glycosyl transferase, family 2
RK21_RS17220	COG0438	transferase activity, transferring glycosyl groups
RK21_RS17250	COG3436	PFAM IS66 Orf2 family protein
RK21_RS17260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RK21_RS17265	COG3754	Rhamnan synthesis protein F
RK21_RS17280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RK21_RS17295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RK21_RS17335	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RK21_RS17335	COG0662	Cupin 2, conserved barrel domain protein
RK21_RS17340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RK21_RS17350	COG0776	regulation of translation
RK21_RS17355	COG2801	Transposase and inactivated derivatives
RK21_RS17360	COG2963	transposase activity
RK21_RS17375	COG3385	transposase activity
RK21_RS17385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RK21_RS17390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RK21_RS17400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RK21_RS17410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RK21_RS17415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK21_RS17420	COG0546	phosphoglycolate phosphatase activity
RK21_RS17425	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS17435	COG5002	protein histidine kinase activity
RK21_RS17435	COG5001	Diguanylate cyclase
RK21_RS17450	COG1054	Belongs to the UPF0176 family
RK21_RS17455	COG0271	Belongs to the BolA IbaG family
RK21_RS17465	COG0114	fumarate hydratase activity
RK21_RS17470	COG0697	spore germination
RK21_RS17475	COG2326	polyphosphate kinase activity
RK21_RS17480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS17480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RK21_RS17485	COG0367	asparagine synthase
RK21_RS17490	COG0189	ligase activity
RK21_RS17490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RK21_RS17495	COG1363	Peptidase, m42
RK21_RS17500	COG3089	Belongs to the UPF0270 family
RK21_RS17505	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RK21_RS17520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK21_RS17525	COG3162	membrane
RK21_RS17530	COG2113	Glycine betaine
RK21_RS17545	COG2801	Transposase and inactivated derivatives
RK21_RS17560	COG2853	Lipoprotein
RK21_RS17570	COG1560	Kdo2-lipid A biosynthetic process
RK21_RS17575	COG0850	regulation of cytokinetic process
RK21_RS17580	COG2894	cell division
RK21_RS17585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RK21_RS17590	COG0564	pseudouridine synthase activity
RK21_RS17595	COG1362	aminopeptidase activity
RK21_RS17600	COG0668	transmembrane transport
RK21_RS17620	COG0395	ABC-type sugar transport system, permease component
RK21_RS17650	COG3300	MHYT domain
RK21_RS17650	COG5001	Diguanylate cyclase
RK21_RS17665	COG3339	Conserved Protein
RK21_RS17670	COG0545	Peptidyl-prolyl cis-trans isomerase
RK21_RS17680	COG0583	DNA-binding transcription factor activity
RK21_RS17685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK21_RS17685	COG2146	nitrite reductase [NAD(P)H] activity
RK21_RS17690	COG2146	nitrite reductase [NAD(P)H] activity
RK21_RS17690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK21_RS17695	COG0243	molybdopterin cofactor binding
RK21_RS17700	COG0024	Methionine aminopeptidase
RK21_RS17725	COG2974	May be involved in recombination
RK21_RS17730	COG0385	Bile acid
RK21_RS17735	COG2076	Multidrug Resistance protein
RK21_RS17740	COG0477	Major facilitator Superfamily
RK21_RS17745	COG2814	Major facilitator Superfamily
RK21_RS17750	COG2205	protein histidine kinase activity
RK21_RS17780	COG0583	DNA-binding transcription factor activity
RK21_RS17800	COG1846	Transcriptional regulator
RK21_RS17810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RK21_RS17815	COG0406	alpha-ribazole phosphatase activity
RK21_RS17820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RK21_RS17830	COG1492	cobalamin metabolic process
RK21_RS17845	COG0778	Nitroreductase
RK21_RS17850	COG1797	cobyrinic acid a,c-diamide synthase activity
RK21_RS17890	COG0791	NLP P60 protein
RK21_RS17895	COG0791	NLP P60 protein
RK21_RS17905	COG0628	permease
RK21_RS17915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RK21_RS17920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RK21_RS17935	COG3122	Protein conserved in bacteria
RK21_RS17940	COG3956	TIGRFAM MazG family protein
RK21_RS17945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK21_RS17950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RK21_RS17970	COG5002	protein histidine kinase activity
RK21_RS17970	COG2205	protein histidine kinase activity
RK21_RS17970	COG0784	Response regulator, receiver
RK21_RS17975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK21_RS17995	COG1393	Belongs to the ArsC family
RK21_RS18015	COG0037	tRNA processing
RK21_RS18025	COG3091	SprT-like family
RK21_RS18035	COG0583	DNA-binding transcription factor activity
RK21_RS18050	COG3148	PFAM DTW domain containing protein
RK21_RS18070	COG2137	regulation of response to DNA damage stimulus
RK21_RS18075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RK21_RS18080	COG1546	Belongs to the CinA family
RK21_RS18085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RK21_RS18090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RK21_RS18105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RK21_RS18110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RK21_RS18115	COG0585	pseudouridine synthase activity
RK21_RS18120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RK21_RS18130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RK21_RS18140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RK21_RS18150	COG0148	phosphopyruvate hydratase activity
RK21_RS18155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RK21_RS18160	COG0504	CTP synthase activity
RK21_RS18165	COG0037	tRNA processing
RK21_RS18170	COG0825	malonyl-CoA metabolic process
RK21_RS18180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RK21_RS18185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK21_RS18190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK21_RS18195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK21_RS18200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK21_RS18220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RK21_RS18230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RK21_RS18235	COG0233	cytoplasmic translational termination
RK21_RS18240	COG0528	UMP kinase activity
RK21_RS18245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RK21_RS18250	COG0052	Belongs to the universal ribosomal protein uS2 family
RK21_RS18255	COG0024	Methionine aminopeptidase
RK21_RS18260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RK21_RS18265	COG0436	Aminotransferase
RK21_RS18270	COG0025	NhaP-type Na H and K H
RK21_RS18280	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
RK21_RS18290	COG1393	Belongs to the ArsC family
RK21_RS18295	COG2171	N-acyltransferase activity
RK21_RS18300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RK21_RS18310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RK21_RS18315	COG1215	transferase activity, transferring glycosyl groups
RK21_RS18320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK21_RS18325	COG2226	methyltransferase
RK21_RS18340	COG2937	Belongs to the GPAT DAPAT family
RK21_RS18370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS18380	COG0742	ribosomal rna small subunit methyltransferase
RK21_RS18415	COG0563	adenylate kinase activity
RK21_RS18420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RK21_RS18435	COG2885	chlorophyll binding
RK21_RS18445	COG1073	alpha beta
RK21_RS18465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RK21_RS18475	COG4251	negative regulation of phosphorylation
RK21_RS18475	COG3706	GGDEF domain
RK21_RS18475	COG2203	Gaf domain
RK21_RS18475	COG5001	Diguanylate cyclase
RK21_RS18480	COG2201	protein-glutamate methylesterase activity
RK21_RS18495	COG0457	Tetratricopeptide repeat
RK21_RS18495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RK21_RS18505	COG0840	transmembrane signaling receptor activity
RK21_RS18510	COG2979	Protein of unknown function (DUF533)
RK21_RS18515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK21_RS18520	COG3842	ATPase activity
RK21_RS18525	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK21_RS18530	COG1177	transmembrane transport
RK21_RS18535	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS18545	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS18565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RK21_RS18600	COG4974	Belongs to the 'phage' integrase family
RK21_RS18605	COG1607	acyl-coa hydrolase
RK21_RS18610	COG0335	large ribosomal subunit rRNA binding
RK21_RS18615	COG0336	Belongs to the RNA methyltransferase TrmD family
RK21_RS18620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RK21_RS18625	COG0228	four-way junction DNA binding
RK21_RS18630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RK21_RS18640	COG4536	flavin adenine dinucleotide binding
RK21_RS18645	COG0477	Major facilitator Superfamily
RK21_RS18650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RK21_RS18670	COG0494	nUDIX hydrolase
RK21_RS18735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK21_RS18765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK21_RS18770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK21_RS18785	COG0047	phosphoribosylformylglycinamidine synthase activity
RK21_RS18785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RK21_RS18790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RK21_RS18795	COG0590	tRNA wobble adenosine to inosine editing
RK21_RS18805	COG2369	cell adhesion
RK21_RS18810	COG1397	ADP-ribosylglycohydrolase
RK21_RS18840	COG0519	Catalyzes the synthesis of GMP from XMP
RK21_RS18840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RK21_RS18860	COG0583	DNA-binding transcription factor activity
RK21_RS18865	COG1570	exodeoxyribonuclease VII activity
RK21_RS18870	COG0739	heme binding
RK21_RS18875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RK21_RS18880	COG0800	Aldolase
RK21_RS18895	COG1737	Transcriptional regulator
RK21_RS18900	COG0676	glucose-6-phosphate 1-epimerase activity
RK21_RS18910	COG3842	ATPase activity
RK21_RS18920	COG1175	transmembrane transport
RK21_RS18980	COG2832	Protein of unknown function (DUF454)
RK21_RS18995	COG2235	arginine
RK21_RS19000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RK21_RS19020	COG0786	glutamate:sodium symporter activity
RK21_RS19045	COG0509	glycine decarboxylation via glycine cleavage system
RK21_RS19050	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK21_RS19050	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK21_RS19055	COG1760	l-serine dehydratase
RK21_RS19060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RK21_RS19065	COG1278	Cold shock
RK21_RS19075	COG0795	lipopolysaccharide-transporting ATPase activity
RK21_RS19080	COG0795	lipopolysaccharide-transporting ATPase activity
RK21_RS19090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RK21_RS19105	COG0525	valine-tRNA ligase activity
RK21_RS19110	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
RK21_RS19115	COG0776	regulation of translation
RK21_RS19120	COG3081	Nucleoid-associated protein
RK21_RS19125	COG2827	Endonuclease containing a URI domain
RK21_RS19135	COG2807	transmembrane transport
RK21_RS19140	COG2186	Transcriptional regulator
RK21_RS19145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RK21_RS19150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RK21_RS19155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RK21_RS19160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RK21_RS19180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RK21_RS19185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RK21_RS19190	COG1127	ABC transporter
RK21_RS19200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RK21_RS19210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RK21_RS19215	COG1137	ATPase activity
RK21_RS19220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RK21_RS19225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RK21_RS19235	COG1660	Displays ATPase and GTPase activities
RK21_RS19240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK21_RS19260	COG0312	modulator of DNA gyrase
RK21_RS19265	COG3028	Belongs to the UPF0307 family
RK21_RS19270	COG0312	modulator of DNA gyrase
RK21_RS19275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK21_RS19290	COG0424	maF-like protein
RK21_RS19300	COG1792	Involved in formation and maintenance of cell shape
RK21_RS19305	COG1077	Cell shape determining protein MreB Mrl
RK21_RS19310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RK21_RS19315	COG0154	amidase activity
RK21_RS19320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RK21_RS19325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RK21_RS19335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK21_RS19340	COG1113	amino acid transport
RK21_RS19350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RK21_RS19365	COG0747	negative chemotaxis
RK21_RS19370	COG0747	negative chemotaxis
RK21_RS19380	COG0747	negative chemotaxis
RK21_RS19385	COG0601	transmembrane transport
RK21_RS19390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK21_RS19395	COG0444	Belongs to the ABC transporter superfamily
RK21_RS19400	COG4608	Belongs to the ABC transporter superfamily
RK21_RS19410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS19425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RK21_RS19450	COG4772	TonB-dependent receptor
RK21_RS19465	COG0019	diaminopimelate decarboxylase activity
RK21_RS19475	COG3128	pkhd-type hydroxylase
RK21_RS19480	COG4774	siderophore transport
RK21_RS19495	COG0436	Aminotransferase
RK21_RS19500	COG1160	GTP binding
RK21_RS19515	COG0124	histidyl-tRNA synthetase
RK21_RS19520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RK21_RS19525	COG1426	Protein conserved in bacteria
RK21_RS19535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RK21_RS19540	COG0105	UTP biosynthetic process
RK21_RS19550	COG0633	Ferredoxin
RK21_RS19555	COG0443	Heat shock 70 kDa protein
RK21_RS19560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RK21_RS19565	COG0316	Belongs to the HesB IscA family
RK21_RS19575	COG1104	cysteine desulfurase activity
RK21_RS19585	COG1045	serine acetyltransferase
RK21_RS19600	COG3134	Outer membrane lipoprotein
RK21_RS19615	COG1862	Preprotein translocase
RK21_RS19620	COG0343	queuine tRNA-ribosyltransferase activity
RK21_RS19625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RK21_RS19655	COG0154	amidase activity
RK21_RS19660	COG0765	amino acid transport
RK21_RS19665	COG0765	amino acid transport
RK21_RS19690	COG3781	membrane
RK21_RS19695	COG3639	organic phosphonate transmembrane transporter activity
RK21_RS19700	COG3639	organic phosphonate transmembrane transporter activity
RK21_RS19705	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RK21_RS19710	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RK21_RS19715	COG0709	Synthesizes selenophosphate from selenide and ATP
RK21_RS19720	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RK21_RS19735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK21_RS19750	COG0727	PFAM Uncharacterised protein family (UPF0153)
RK21_RS19760	COG0436	Aminotransferase
RK21_RS19765	COG0109	protoheme IX farnesyltransferase activity
RK21_RS19770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RK21_RS19775	COG1845	cytochrome c oxidase, subunit III
RK21_RS19780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RK21_RS19785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RK21_RS19790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RK21_RS19795	COG1017	nitric oxide dioxygenase activity
RK21_RS19795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK21_RS19800	COG3604	Transcriptional regulator
RK21_RS19825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK21_RS19850	COG2203	Gaf domain
RK21_RS19850	COG3706	GGDEF domain
RK21_RS19850	COG4251	negative regulation of phosphorylation
RK21_RS19850	COG5001	Diguanylate cyclase
RK21_RS19860	COG3530	Putative quorum-sensing-regulated virulence factor
RK21_RS19865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RK21_RS19865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK21_RS19865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK21_RS19870	COG1105	Belongs to the carbohydrate kinase PfkB family
RK21_RS19880	COG1609	Transcriptional regulator
RK21_RS19885	COG0084	hydrolase, TatD family'
RK21_RS19910	COG0492	ferredoxin-NADP+ reductase activity
RK21_RS19915	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
RK21_RS19940	COG0386	Belongs to the glutathione peroxidase family
RK21_RS19955	COG0857	belongs to the CobB CobQ family
RK21_RS19955	COG0280	phosphate acetyltransferase
RK21_RS19960	COG2885	chlorophyll binding
RK21_RS19965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK21_RS19975	COG2336	PFAM SpoVT AbrB
RK21_RS20005	COG0318	PFAM AMP-dependent synthetase and ligase
RK21_RS20010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK21_RS20015	COG2813	Specifically methylates the guanine in position
RK21_RS20020	COG2119	membrane
RK21_RS20030	COG2135	peptidase activity
RK21_RS20065	COG0579	oxidoreductase
RK21_RS20085	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RK21_RS20090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RK21_RS20100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RK21_RS20105	COG1090	epimerase
RK21_RS20110	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
RK21_RS20115	COG3272	Protein of unknown function (DUF1722)
RK21_RS20120	COG0789	Transcriptional regulator
RK21_RS20125	COG0415	Belongs to the DNA photolyase family
RK21_RS20140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RK21_RS20145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RK21_RS20155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RK21_RS20160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RK21_RS20170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RK21_RS20175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RK21_RS20185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RK21_RS20190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RK21_RS20195	COG0193	aminoacyl-tRNA hydrolase activity
RK21_RS20200	COG0012	GTP binding
RK21_RS20210	COG5377	YqaJ viral recombinase family
RK21_RS20220	COG2003	Belongs to the UPF0758 family
RK21_RS20355	COG3039	Transposase
RK21_RS20365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK21_RS20370	COG1454	alcohol dehydrogenase
RK21_RS20380	COG3039	Transposase
RK21_RS20395	COG2801	Transposase and inactivated derivatives
RK21_RS20400	COG2963	transposase activity
RK21_RS20490	COG0628	permease
RK21_RS20505	COG1335	isochorismatase
RK21_RS20510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK21_RS20515	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS20520	COG3608	succinylglutamate desuccinylase aspartoacylase
RK21_RS20525	COG0006	proline dipeptidase activity
RK21_RS20530	COG2423	ornithine cyclodeaminase activity
RK21_RS20535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RK21_RS20540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS20545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS20550	COG0765	amino acid transport
RK21_RS20555	COG0765	amino acid transport
RK21_RS20560	COG1126	abc transporter atp-binding protein
RK21_RS20595	COG1511	domain protein
RK21_RS20595	COG3264	Mechanosensitive ion channel
RK21_RS20600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RK21_RS20600	COG2169	Transcriptional regulator
RK21_RS20615	COG2223	nitrite transmembrane transporter activity
RK21_RS20650	COG0456	acetyltransferase
RK21_RS20675	COG3045	CreA protein
RK21_RS20680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RK21_RS20685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RK21_RS20690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RK21_RS20695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RK21_RS20700	COG0142	geranyltranstransferase activity
RK21_RS20705	COG2824	Alkylphosphonate utilization operon protein PhnA
RK21_RS20715	COG0545	Peptidyl-prolyl cis-trans isomerase
RK21_RS20725	COG2862	Uncharacterized protein family, UPF0114
RK21_RS20735	COG1067	ATP-dependent peptidase activity
RK21_RS20755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK21_RS20760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RK21_RS20765	COG0488	(ABC) transporter
RK21_RS20780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK21_RS20795	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS20805	COG1522	sequence-specific DNA binding
RK21_RS20815	COG0583	DNA-binding transcription factor activity
RK21_RS20820	COG0833	amino acid
RK21_RS20825	COG0626	cystathionine gamma-synthase activity
RK21_RS20835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS20840	COG0765	amino acid transport
RK21_RS20845	COG0039	L-malate dehydrogenase activity
RK21_RS20850	COG4191	Histidine kinase
RK21_RS20880	COG2963	transposase activity
RK21_RS20885	COG2801	Transposase and inactivated derivatives
RK21_RS20900	COG0582	viral genome integration into host DNA
RK21_RS20925	COG0237	dephospho-CoA kinase activity
RK21_RS20930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RK21_RS20955	COG1252	NADH dehydrogenase
RK21_RS20985	COG0542	response to heat
RK21_RS21010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS21040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RK21_RS21045	COG1047	Peptidyl-prolyl cis-trans
RK21_RS21050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RK21_RS21055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RK21_RS21060	COG0196	riboflavin kinase activity
RK21_RS21070	COG0268	Binds directly to 16S ribosomal RNA
RK21_RS21075	COG3008	intermembrane lipid transfer
RK21_RS21080	COG2995	paraquat-inducible protein a
RK21_RS21085	COG2995	paraquat-inducible protein a
RK21_RS21120	COG1309	transcriptional regulator
RK21_RS21125	COG1739	Uncharacterized protein family UPF0029
RK21_RS21130	COG0300	oxidoreductase activity
RK21_RS21135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RK21_RS21145	COG2814	Major facilitator Superfamily
RK21_RS21160	COG2217	Heavy metal translocating P-type atpase
RK21_RS21170	COG0840	transmembrane signaling receptor activity
RK21_RS21175	COG2207	Transcriptional regulator
RK21_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
RK21_RS21190	COG2030	dehydratase
RK21_RS21200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK21_RS21230	COG4953	penicillin-binding protein 1C
RK21_RS21240	COG2373	Large extracellular alpha-helical protein
RK21_RS21245	COG0534	Mate efflux family protein
RK21_RS21255	COG1166	arginine decarboxylase activity
RK21_RS21260	COG0023	Translation Initiation Factor
RK21_RS21295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RK21_RS21310	COG3284	Transcriptional regulator
RK21_RS21315	COG3199	ATP-NAD kinase
RK21_RS21320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RK21_RS21325	COG0022	dehydrogenase e1 component
RK21_RS21335	COG1063	alcohol dehydrogenase
RK21_RS21345	COG0702	epimerase
RK21_RS21360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RK21_RS21365	COG3284	Transcriptional regulator
RK21_RS21375	COG0531	amino acid
RK21_RS21380	COG4303	Ethanolamine ammonia lyase large subunit
RK21_RS21385	COG4302	ethanolamine ammonia-lyase activity
RK21_RS21390	COG0456	acetyltransferase
RK21_RS21395	COG0586	Pfam SNARE associated Golgi protein
RK21_RS21405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RK21_RS21415	COG2132	Multicopper oxidase
RK21_RS21435	COG0579	oxidoreductase
RK21_RS21445	COG1690	Belongs to the RtcB family
RK21_RS21450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK21_RS21455	COG1722	exodeoxyribonuclease VII activity
RK21_RS21460	COG0142	geranyltranstransferase activity
RK21_RS21465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RK21_RS21470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK21_RS21480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK21_RS21490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RK21_RS21495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RK21_RS21500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RK21_RS21505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RK21_RS21520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK21_RS21520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK21_RS21525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RK21_RS21535	COG2264	protein methyltransferase activity
RK21_RS21540	COG3118	belongs to the thioredoxin family
RK21_RS21570	COG3047	cAMP biosynthetic process
RK21_RS21585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK21_RS21610	COG1115	amino acid carrier protein
RK21_RS21615	COG0252	asparaginase activity
RK21_RS21625	COG3276	selenocysteine insertion sequence binding
RK21_RS21630	COG1921	L-seryl-tRNASec selenium transferase activity
RK21_RS21635	COG3058	Necessary for formate dehydrogenase activity
RK21_RS21640	COG2864	formate dehydrogenase
RK21_RS21645	COG0437	4 iron, 4 sulfur cluster binding
RK21_RS21650	COG0243	molybdopterin cofactor binding
RK21_RS21650	COG3383	formate dehydrogenase (NAD+) activity
RK21_RS21655	COG0243	molybdopterin cofactor binding
RK21_RS21655	COG3383	formate dehydrogenase (NAD+) activity
RK21_RS21660	COG4221	oxidoreductase activity
RK21_RS21670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS21675	COG0629	single-stranded DNA binding
RK21_RS21680	COG2814	Major facilitator Superfamily
RK21_RS21685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RK21_RS21690	COG2193	ferroxidase activity
RK21_RS21695	COG0753	catalase activity
RK21_RS21700	COG0203	ribosomal protein L17
RK21_RS21705	COG0202	RNA polymerase activity
RK21_RS21710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RK21_RS21715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RK21_RS21720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RK21_RS21725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RK21_RS21735	COG0200	Binds to the 23S rRNA
RK21_RS21740	COG1841	ribosomal large subunit assembly
RK21_RS21745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RK21_RS21750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RK21_RS21755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RK21_RS21760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RK21_RS21765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RK21_RS21770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RK21_RS21775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RK21_RS21780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RK21_RS21785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RK21_RS21790	COG0255	Belongs to the universal ribosomal protein uL29 family
RK21_RS21795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RK21_RS21800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RK21_RS21805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RK21_RS21810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RK21_RS21815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RK21_RS21820	COG0089	rRNA binding
RK21_RS21825	COG0088	Forms part of the polypeptide exit tunnel
RK21_RS21830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RK21_RS21835	COG0051	transcription antitermination factor activity, RNA binding
RK21_RS21840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RK21_RS21845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK21_RS21850	COG0049	tRNA binding
RK21_RS21855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RK21_RS21860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RK21_RS21865	COG0085	RNA polymerase activity
RK21_RS21870	COG0222	ribosome binding
RK21_RS21875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RK21_RS21880	COG0081	regulation of translation
RK21_RS21885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RK21_RS21905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RK21_RS21930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RK21_RS21935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RK21_RS21935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RK21_RS21955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RK21_RS21960	COG0739	heme binding
RK21_RS21965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RK21_RS21970	COG0316	Belongs to the HesB IscA family
RK21_RS21975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RK21_RS21980	COG1981	membrane
RK21_RS21990	COG0300	oxidoreductase activity
RK21_RS21995	COG0537	adenosine 5'-monophosphoramidase activity
RK21_RS22000	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RK21_RS22010	COG1765	OsmC-like protein
RK21_RS22025	COG0134	indole-3-glycerol-phosphate synthase activity
RK21_RS22030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RK21_RS22035	COG0512	Glutamine amidotransferase of anthranilate synthase
RK21_RS22040	COG4625	pathogenesis
RK21_RS22040	COG3240	lipase activity
RK21_RS22045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK21_RS22050	COG0546	phosphoglycolate phosphatase activity
RK21_RS22055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RK21_RS22065	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK21_RS22075	COG3842	ATPase activity
RK21_RS22080	COG2197	response regulator
RK21_RS22085	COG4585	Histidine kinase
RK21_RS22095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RK21_RS22100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RK21_RS22105	COG3178	'Phosphotransferase
RK21_RS22110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RK21_RS22115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK21_RS22120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RK21_RS22125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RK21_RS22130	COG2967	ApaG domain
RK21_RS22135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RK21_RS22140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK21_RS22145	COG2766	serine protein kinase
RK21_RS22150	COG2718	Belongs to the UPF0229 family
RK21_RS22155	COG2719	SpoVR family
RK21_RS22160	COG0617	tRNA 3'-terminal CCA addition
RK21_RS22170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RK21_RS22175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RK21_RS22180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RK21_RS22185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RK21_RS22190	COG0358	DNA primase activity
RK21_RS22215	COG2963	transposase activity
RK21_RS22220	COG2801	Transposase and inactivated derivatives
RK21_RS22245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK21_RS22250	COG1025	Belongs to the peptidase M16 family
RK21_RS22255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RK21_RS22260	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RK21_RS22270	COG0535	radical SAM domain protein
RK21_RS22285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RK21_RS22290	COG0583	DNA-binding transcription factor activity
RK21_RS22295	COG1960	acyl-CoA dehydrogenase activity
RK21_RS22300	COG3706	GGDEF domain
RK21_RS22305	COG1960	acyl-CoA dehydrogenase activity
RK21_RS22330	COG0156	8-amino-7-oxononanoate synthase activity
RK21_RS22335	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RK21_RS22340	COG1040	competence protein
RK21_RS22345	COG3585	molybdate ion transport
RK21_RS22345	COG2005	Transcriptional regulator
RK21_RS22365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RK21_RS22370	COG2204	response regulator
RK21_RS22380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK21_RS22385	COG1595	DNA-templated transcription, initiation
RK21_RS22390	COG3712	iron ion homeostasis
RK21_RS22395	COG4774	siderophore transport
RK21_RS22435	COG0438	transferase activity, transferring glycosyl groups
RK21_RS22450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RK21_RS22470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK21_RS22480	COG4452	Inner membrane protein CreD
RK21_RS22485	COG2205	protein histidine kinase activity
RK21_RS22490	COG0745	RESPONSE REGULATOR receiver
RK21_RS22500	COG0204	Acyl-transferase
RK21_RS22505	COG0531	amino acid
RK21_RS22515	COG1063	alcohol dehydrogenase
RK21_RS22550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK21_RS22560	COG0840	transmembrane signaling receptor activity
RK21_RS22585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK21_RS22585	COG1017	nitric oxide dioxygenase activity
RK21_RS22605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RK21_RS22610	COG0247	lactate metabolic process
RK21_RS22610	COG2181	nitrate reductase activity
RK21_RS22615	COG0446	pyridine nucleotide-disulphide oxidoreductase
RK21_RS22615	COG1902	pentaerythritol trinitrate reductase activity
RK21_RS22655	COG3246	L-lysine catabolic process to acetate
RK21_RS22660	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK21_RS22680	COG1760	l-serine dehydratase
RK21_RS22690	COG4176	ABC-type proline glycine betaine transport system permease component
RK21_RS22695	COG4175	Glycine betaine
RK21_RS22700	COG0107	imidazoleglycerol-phosphate synthase activity
RK21_RS22705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RK21_RS22715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RK21_RS22720	COG0131	Imidazoleglycerol-phosphate dehydratase
RK21_RS22725	COG2223	nitrite transmembrane transporter activity
RK21_RS22740	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RK21_RS22775	COG4215	(ABC) transporter
RK21_RS22825	COG0069	glutamate synthase activity
RK21_RS22840	COG3344	reverse transcriptase
RK21_RS22845	COG2957	Belongs to the agmatine deiminase family
RK21_RS22870	COG1218	3'(2'),5'-bisphosphate nucleotidase
RK21_RS22875	COG0494	nUDIX hydrolase
RK21_RS22880	COG1011	Hydrolase
RK21_RS22885	COG1652	LysM domain
RK21_RS22890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RK21_RS22895	COG0243	molybdopterin cofactor binding
RK21_RS22910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RK21_RS22915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RK21_RS22925	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RK21_RS22930	COG4067	protein conserved in archaea
RK21_RS22930	COG0189	ligase activity
RK21_RS22935	COG0189	ligase activity
RK21_RS22965	COG2267	carboxylic ester hydrolase activity
RK21_RS22970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS22975	COG1126	abc transporter atp-binding protein
RK21_RS22980	COG0765	amino acid transport
RK21_RS22985	COG0765	amino acid transport
RK21_RS23005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RK21_RS23010	COG4208	sulfate ABC transporter
RK21_RS23020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RK21_RS23030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK21_RS23055	COG1177	transmembrane transport
RK21_RS23060	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK21_RS23065	COG3842	ATPase activity
RK21_RS23085	COG0174	glutamine synthetase
RK21_RS23095	COG0174	glutamine synthetase
RK21_RS23100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RK21_RS23100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RK21_RS23105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK21_RS23115	COG1522	sequence-specific DNA binding
RK21_RS23125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK21_RS23135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK21_RS23135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK21_RS23140	COG0509	glycine decarboxylation via glycine cleavage system
RK21_RS23145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RK21_RS23150	COG1178	ABC-type Fe3 transport system permease component
RK21_RS23160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK21_RS23170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK21_RS23175	COG0006	proline dipeptidase activity
RK21_RS23180	COG3079	Belongs to the UPF0149 family
RK21_RS23195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RK21_RS23205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS23210	COG1129	ABC transporter
RK21_RS23210	COG0842	Transport permease protein
RK21_RS23215	COG0842	Transport permease protein
RK21_RS23240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RK21_RS23255	COG0248	Ppx GppA phosphatase
RK21_RS23260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RK21_RS23275	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RK21_RS23280	COG1671	Belongs to the UPF0178 family
RK21_RS23290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK21_RS23300	COG1965	Belongs to the frataxin family
RK21_RS23310	COG0019	diaminopimelate decarboxylase activity
RK21_RS23315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RK21_RS23325	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RK21_RS23330	COG0546	phosphoglycolate phosphatase activity
RK21_RS23340	COG0004	ammonium transporteR
RK21_RS23345	COG0347	Belongs to the P(II) protein family
RK21_RS23360	COG0606	chelatase, subunit chli
RK21_RS23365	COG4566	intracellular signal transduction
RK21_RS23370	COG4566	intracellular signal transduction
RK21_RS23375	COG4191	Histidine kinase
RK21_RS23380	COG1335	isochorismatase
RK21_RS23400	COG3093	addiction module antidote protein HigA
RK21_RS23410	COG1335	isochorismatase
RK21_RS23415	COG0583	DNA-binding transcription factor activity
RK21_RS23445	COG1335	isochorismatase
RK21_RS23455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS23460	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS23465	COG0583	DNA-binding transcription factor activity
RK21_RS23470	COG5383	Protein conserved in bacteria
RK21_RS23480	COG0534	Mate efflux family protein
RK21_RS23495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RK21_RS23500	COG0427	acetyl-CoA hydrolase
RK21_RS23520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS23535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK21_RS23545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK21_RS23550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK21_RS23560	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS23570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RK21_RS23580	COG0747	negative chemotaxis
RK21_RS23585	COG2003	Belongs to the UPF0758 family
RK21_RS23590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RK21_RS23595	COG0756	dUTP diphosphatase activity
RK21_RS23600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK21_RS23605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RK21_RS23610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RK21_RS23615	COG0708	Exodeoxyribonuclease III
RK21_RS23625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RK21_RS23630	COG1561	YicC-like family, N-terminal region
RK21_RS23635	COG0194	GDP metabolic process
RK21_RS23645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RK21_RS23650	COG0174	glutamine synthetase
RK21_RS23660	COG1758	RNA polymerase activity
RK21_RS23665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK21_RS23690	COG0848	biopolymer transport protein
RK21_RS23700	COG0583	DNA-binding transcription factor activity
RK21_RS23705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RK21_RS23735	COG3161	chorismate lyase activity
RK21_RS23740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RK21_RS23760	COG1253	flavin adenine dinucleotide binding
RK21_RS23765	COG0739	heme binding
RK21_RS23775	COG0704	Plays a role in the regulation of phosphate uptake
RK21_RS23780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK21_RS23785	COG0581	inorganic phosphate transmembrane transporter activity
RK21_RS23800	COG0477	Major facilitator Superfamily
RK21_RS23805	COG1607	acyl-coa hydrolase
RK21_RS23840	COG0583	DNA-binding transcription factor activity
RK21_RS23845	COG1027	Aspartate ammonia-lyase
RK21_RS23885	COG0511	ligase activity, forming carbon-carbon bonds
RK21_RS23885	COG5016	pyruvate
RK21_RS23890	COG0439	Biotin carboxylase
RK21_RS23895	COG0583	DNA-binding transcription factor activity
RK21_RS23905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RK21_RS23915	COG0210	DNA helicase
RK21_RS23930	COG4651	solute:proton antiporter activity
RK21_RS23930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RK21_RS23935	COG1607	acyl-coa hydrolase
RK21_RS23940	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RK21_RS23950	COG0523	cobalamin synthesis protein
RK21_RS23965	COG1469	GTP cyclohydrolase I activity
RK21_RS23975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK21_RS23980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RK21_RS23985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK21_RS24020	COG1247	-acetyltransferase
RK21_RS24025	COG2072	flavoprotein involved in K transport
RK21_RS24035	COG0431	NADPH-dependent FMN reductase
RK21_RS24040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RK21_RS24045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RK21_RS24050	COG0640	Transcriptional regulator
RK21_RS24080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK21_RS24090	COG0573	inorganic phosphate transmembrane transporter activity
RK21_RS24095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RK21_RS24125	COG2197	response regulator
RK21_RS24140	COG3039	Transposase
RK21_RS24165	COG2801	Transposase and inactivated derivatives
RK21_RS24170	COG2963	transposase activity
RK21_RS24205	COG2814	Major facilitator Superfamily
RK21_RS24215	COG1230	cation diffusion facilitator family transporter
RK21_RS24240	COG1238	metal cluster binding
RK21_RS24255	COG0659	secondary active sulfate transmembrane transporter activity
RK21_RS24260	COG0589	response to stress
RK21_RS24270	COG2433	Pfam Transposase IS66
RK21_RS24390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RK21_RS24395	COG1349	DNA-binding transcription factor activity
RK21_RS24400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RK21_RS24405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RK21_RS24410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RK21_RS24415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RK21_RS24420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RK21_RS24425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RK21_RS24430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RK21_RS24440	COG0356	it plays a direct role in the translocation of protons across the membrane
RK21_RS24445	COG3312	ion transport
RK21_RS24450	COG1475	DNA binding
RK21_RS24455	COG1192	Involved in chromosome partitioning
RK21_RS24460	COG0357	Ribosomal RNA small subunit methyltransferase G
RK21_RS24465	COG0445	tRNA wobble uridine modification
RK21_RS24470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RK21_RS24475	COG0706	membrane insertase activity
RK21_RS24485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RK21_RS24490	COG0592	DNA-directed DNA polymerase activity
RK21_RS24495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RK21_RS24500	COG0187	DNA topoisomerase II activity
RK21_RS24510	COG2801	Transposase and inactivated derivatives
RK21_RS24515	COG2963	transposase activity
RK21_RS24530	COG2194	sulfuric ester hydrolase activity
RK21_RS24580	COG0463	Glycosyl transferase, family 2
RK21_RS24680	COG0477	Major facilitator Superfamily
RK21_RS24690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RK21_RS24695	COG0751	glycine-tRNA ligase activity
RK21_RS24700	COG0752	glycyl-tRNA synthetase alpha subunit
RK21_RS24705	COG2818	Glycosylase
RK21_RS24720	COG0569	domain protein
RK21_RS24725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RK21_RS24730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RK21_RS24735	COG0242	peptide deformylase activity
RK21_RS24740	COG0758	DNA mediated transformation
RK21_RS24745	COG0009	L-threonylcarbamoyladenylate synthase
RK21_RS24760	COG0408	coproporphyrinogen oxidase activity
RK21_RS24765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK21_RS24770	COG0659	secondary active sulfate transmembrane transporter activity
RK21_RS24780	COG3119	arylsulfatase activity
RK21_RS24800	COG0159	tryptophan synthase activity
RK21_RS24805	COG0133	tryptophan synthase activity
RK21_RS24820	COG3360	Dodecin
RK21_RS24830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK21_RS24835	COG1764	response to oxidative stress
RK21_RS24865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RK21_RS24870	COG0339	signal peptide processing
RK21_RS24875	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RK21_RS24880	COG0339	signal peptide processing
RK21_RS24895	COG0659	secondary active sulfate transmembrane transporter activity
RK21_RS24905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RK21_RS24910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RK21_RS24915	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RK21_RS24930	COG3346	SURF1 family
RK21_RS24940	COG1612	heme a metabolic process
RK21_RS24945	COG0109	protoheme IX farnesyltransferase activity
RK21_RS24960	COG2011	ABC-type metal ion transport system permease component
RK21_RS24965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RK21_RS24980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK21_RS24985	COG1121	(ABC) transporter
RK21_RS24990	COG0735	belongs to the Fur family
RK21_RS24995	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RK21_RS25015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RK21_RS25020	COG3245	cytochrome
RK21_RS25030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK21_RS25045	COG3023	N-Acetylmuramoyl-L-alanine amidase
RK21_RS25050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RK21_RS25055	COG5002	protein histidine kinase activity
RK21_RS25060	COG2204	response regulator
RK21_RS25085	COG1301	dicarboxylic acid transport
RK21_RS25090	COG0700	Nucleoside recognition
RK21_RS25105	COG1127	ABC transporter
RK21_RS25110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RK21_RS25125	COG1283	sodium-dependent phosphate transmembrane transporter activity
RK21_RS25130	COG0861	Integral membrane protein TerC family
RK21_RS25135	COG2851	Citrate transporter
RK21_RS25170	COG0427	acetyl-CoA hydrolase
RK21_RS25190	COG0583	DNA-binding transcription factor activity
RK21_RS25195	COG1960	acyl-CoA dehydrogenase activity
RK21_RS25265	COG1802	Transcriptional regulator
RK21_RS25275	COG5001	Diguanylate cyclase
RK21_RS25275	COG3300	MHYT domain
RK21_RS25280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK21_RS25300	COG2175	clavaminate synthase activity
RK21_RS25315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK21_RS25360	COG1289	transmembrane transporter activity
RK21_RS25370	COG1566	PFAM secretion protein HlyD family protein
RK21_RS25390	COG0672	)-iron permease
RK21_RS25405	COG0625	glutathione transferase activity
RK21_RS25410	COG0165	Argininosuccinate lyase
RK21_RS25420	COG0181	hydroxymethylbilane synthase activity
RK21_RS25440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RK21_RS25465	COG0488	(ABC) transporter
RK21_RS25475	COG1280	lysine exporter protein (LysE YggA)
RK21_RS25535	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS25540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK21_RS25550	COG2199	diguanylate cyclase activity
RK21_RS25565	COG2011	ABC-type metal ion transport system permease component
RK21_RS25570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RK21_RS25575	COG1464	Belongs to the NlpA lipoprotein family
RK21_RS25595	COG1126	abc transporter atp-binding protein
RK21_RS25600	COG0765	amino acid transport
RK21_RS25605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK21_RS25610	COG1045	serine acetyltransferase
RK21_RS25615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK21_RS25620	COG2175	clavaminate synthase activity
RK21_RS25625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK21_RS25630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RK21_RS25635	COG4521	taurine ABC transporter
RK21_RS25645	COG0450	alkyl hydroperoxide reductase
RK21_RS25650	COG3344	reverse transcriptase
RK21_RS25655	COG0431	NADPH-dependent FMN reductase
RK21_RS25660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK21_RS25665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RK21_RS25670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK21_RS25675	COG1116	anion transmembrane transporter activity
RK21_RS25690	COG2918	glutathione biosynthetic process
RK21_RS25700	COG2183	response to ionizing radiation
RK21_RS25730	COG1683	Conserved Protein
RK21_RS25745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK21_RS25750	COG0277	FAD linked oxidase domain protein
RK21_RS25755	COG0179	Fumarylacetoacetate (FAA) hydrolase
RK21_RS25760	COG3204	pilus organization
RK21_RS25765	COG3204	pilus organization
RK21_RS25770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RK21_RS25775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RK21_RS25790	COG0494	nUDIX hydrolase
RK21_RS25795	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
RK21_RS25805	COG0730	response to heat
RK21_RS25810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RK21_RS25815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RK21_RS25820	COG0789	Transcriptional regulator
RK21_RS25835	COG3842	ATPase activity
RK21_RS25840	COG1178	ABC-type Fe3 transport system permease component
RK21_RS25845	COG1840	ABC-type Fe3 transport system, periplasmic component
RK21_RS25860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RK21_RS25875	COG1823	symporter activity
RK21_RS25885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RK21_RS25890	COG0583	DNA-binding transcription factor activity
RK21_RS25895	COG0129	dihydroxy-acid dehydratase activity
RK21_RS25900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK21_RS25905	COG0693	protein deglycase activity
RK21_RS25915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RK21_RS25920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RK21_RS25925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RK21_RS25930	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RK21_RS25960	COG0612	Peptidase, M16
RK21_RS25970	COG0742	ribosomal rna small subunit methyltransferase
RK21_RS25975	COG0612	Peptidase, M16
RK21_RS25980	COG0612	Peptidase, M16
RK21_RS25985	COG0552	protein localization to endoplasmic reticulum
RK21_RS25990	COG2884	Cell division ATP-binding protein ftsE
RK21_RS25995	COG2177	Part of the ABC transporter FtsEX involved in
RK21_RS26005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK21_RS26010	COG2363	Small membrane protein
RK21_RS26020	COG2022	thiamine diphosphate biosynthetic process
RK21_RS26025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RK21_RS26035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RK21_RS26040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RK21_RS26050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RK21_RS26050	COG2813	Specifically methylates the guanine in position
RK21_RS26055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RK21_RS26080	COG0791	NLP P60 protein
RK21_RS26095	COG0018	arginyl-trna synthetase
RK21_RS26100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RK21_RS26105	COG0254	rRNA binding
RK21_RS26115	COG0281	malic enzyme
RK21_RS26145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RK21_RS26150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RK21_RS26160	COG0069	glutamate synthase activity
RK21_RS26160	COG0070	glutamate synthase
RK21_RS26160	COG0067	glutamate synthase
RK21_RS26165	COG0493	'glutamate synthase
RK21_RS26170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RK21_RS26180	COG2814	Major facilitator Superfamily
RK21_RS26185	COG0583	DNA-binding transcription factor activity
RK21_RS26190	COG1192	Involved in chromosome partitioning
RK21_RS26195	COG3118	belongs to the thioredoxin family
RK21_RS26200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RK21_RS26205	COG3264	Mechanosensitive ion channel
RK21_RS26205	COG1196	nuclear chromosome segregation
RK21_RS26210	COG3263	regulation of cellular component size
RK21_RS26215	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RK21_RS26220	COG1012	belongs to the aldehyde dehydrogenase family
RK21_RS26225	COG1309	transcriptional regulator
RK21_RS26230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK21_RS26240	COG2861	carbohydrate metabolic process
RK21_RS26245	COG0793	Belongs to the peptidase S41A family
RK21_RS26250	COG4942	peptidase
RK21_RS26255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RK21_RS26260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK21_RS26270	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RK21_RS26275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RK21_RS26290	COG3852	Histidine kinase
RK21_RS26305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK21_RS26305	COG0301	tRNA thio-modification
RK21_RS26310	COG1217	gtp-binding protein TYPA
RK21_RS26325	COG0058	SHG alpha-glucan phosphorylase activity
RK21_RS26330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RK21_RS26350	COG0402	S-adenosylhomocysteine deaminase activity
RK21_RS26355	COG2188	Transcriptional regulator
RK21_RS26365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RK21_RS26370	COG2986	histidine ammonia-lyase
RK21_RS26380	COG1228	amidohydrolase
RK21_RS26400	COG1490	D-aminoacyl-tRNA deacylase activity
RK21_RS26405	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RK21_RS26410	COG2943	transferase activity, transferring hexosyl groups
RK21_RS26420	COG0765	amino acid transport
RK21_RS26425	COG1126	abc transporter atp-binding protein
RK21_RS26430	COG0840	transmembrane signaling receptor activity
RK21_RS26435	COG0840	transmembrane signaling receptor activity
RK21_RS26455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK21_RS26460	COG0140	phosphoribosyl-ATP diphosphatase activity
RK21_RS26465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RK21_RS26470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RK21_RS26480	COG2226	methyltransferase
RK21_RS26525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RK21_RS26530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RK21_RS26535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RK21_RS26540	COG0540	Belongs to the ATCase OTCase family
RK21_RS26545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RK21_RS26550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RK21_RS26555	COG1678	Uncharacterized ACR, COG1678
RK21_RS26565	COG0189	ligase activity
RK21_RS26590	COG0643	Histidine kinase
RK21_RS26590	COG2198	Histidine kinase
RK21_RS26590	COG0784	Response regulator, receiver
RK21_RS26600	COG1272	protein, Hemolysin III
RK21_RS26605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RK21_RS26620	COG3038	cytochrome b561
RK21_RS26625	COG2353	YceI-like domain
RK21_RS26630	COG0513	Belongs to the DEAD box helicase family
RK21_RS26645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RK21_RS26650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RK21_RS26690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RK21_RS26695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RK21_RS26700	COG0640	Transcriptional regulator
RK21_RS26705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RK21_RS26710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK21_RS26715	COG0126	phosphoglycerate kinase activity
RK21_RS26735	COG3300	MHYT domain
RK21_RS26735	COG5001	Diguanylate cyclase
RK21_RS26740	COG1451	nucleotide metabolic process
RK21_RS26750	COG2153	protein acetylation
RK21_RS26760	COG1289	transmembrane transporter activity
RK21_RS26765	COG2081	HI0933 family
RK21_RS26770	COG0513	Belongs to the DEAD box helicase family
RK21_RS26775	COG0477	Major facilitator Superfamily
RK21_RS26780	COG0312	modulator of DNA gyrase
RK21_RS26790	COG1960	acyl-CoA dehydrogenase activity
RK21_RS26805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RK21_RS26805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RK21_RS26805	COG0506	proline dehydrogenase activity
RK21_RS26810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK21_RS26815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RK21_RS26820	COG2192	nodulation
RK21_RS26825	COG0438	transferase activity, transferring glycosyl groups
RK21_RS26850	COG0438	transferase activity, transferring glycosyl groups
RK21_RS26865	COG1132	(ABC) transporter
RK21_RS26870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RK21_RS26870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RK21_RS26880	COG0667	Aldo Keto reductase
RK21_RS26895	COG0583	DNA-binding transcription factor activity
RK21_RS26900	COG1519	Transferase
RK21_RS26920	COG1538	Outer membrane efflux protein
RK21_RS26925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RK21_RS26940	COG0494	nUDIX hydrolase
RK21_RS26950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RK21_RS26955	COG3150	esterase
RK21_RS26970	COG3577	Aspartyl protease
RK21_RS26990	COG3830	Belongs to the UPF0237 family
RK21_RS26990	COG0560	Phosphoserine phosphatase
RK21_RS26995	COG0688	phosphatidylethanolamine metabolic process
RK21_RS27010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RK21_RS27020	COG1162	GTPase activity
RK21_RS27025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RK21_RS27030	COG2860	membrane
RK21_RS27040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RK21_RS27040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RK21_RS27045	COG0802	atpase or kinase
RK21_RS27050	COG0860	N-Acetylmuramoyl-L-alanine amidase
RK21_RS27055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RK21_RS27060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RK21_RS27065	COG1923	regulation of RNA biosynthetic process
RK21_RS27070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RK21_RS27075	COG0330	HflC and HflK could
RK21_RS27080	COG0330	HflC and HflK could
RK21_RS27085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RK21_RS27090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RK21_RS27095	COG0840	transmembrane signaling receptor activity
RK21_RS27125	COG2826	transposase and inactivated derivatives, IS30 family
RK21_RS27135	COG1178	ABC-type Fe3 transport system permease component
RK21_RS27140	COG1840	ABC-type Fe3 transport system, periplasmic component
RK21_RS27155	COG0557	exoribonuclease II activity
RK21_RS27160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK21_RS27165	COG0360	Binds together with S18 to 16S ribosomal RNA
RK21_RS27170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RK21_RS27180	COG0359	binds to the 23S rRNA
RK21_RS27185	COG0305	Participates in initiation and elongation during chromosome replication
RK21_RS27190	COG1032	radical SAM domain protein
RK21_RS27205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RK21_RS27210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RK21_RS27240	COG4221	oxidoreductase activity
RK21_RS27260	COG2982	Protein involved in outer membrane biogenesis
RK21_RS27275	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RK21_RS27300	COG0443	Heat shock 70 kDa protein
RK21_RS27305	COG0484	heat shock protein binding
RK21_RS27310	COG0789	Transcriptional regulator
RK21_RS27325	COG0411	ABC transporter
RK21_RS27345	COG1113	amino acid transport
RK21_RS27355	COG4774	siderophore transport
RK21_RS27375	COG0330	HflC and HflK could
RK21_RS27390	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RK21_RS27400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK21_RS27430	COG2095	MarC family integral membrane protein
RK21_RS27440	COG0151	Belongs to the GarS family
RK21_RS27445	COG0138	bifunctional purine biosynthesis protein purh
RK21_RS27455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK21_RS27465	COG2264	protein methyltransferase activity
RK21_RS27480	COG1346	cytolysis
RK21_RS27490	COG0586	Pfam SNARE associated Golgi protein
RK21_RS27495	COG2094	Belongs to the DNA glycosylase MPG family
RK21_RS27500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RK21_RS27505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RK21_RS27515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RK21_RS27520	COG0768	penicillin binding
RK21_RS27525	COG0772	Belongs to the SEDS family
RK21_RS27530	COG2951	lytic endotransglycosylase activity
RK21_RS27540	COG1686	Belongs to the peptidase S11 family
RK21_RS27545	COG2921	Belongs to the UPF0250 family
RK21_RS27550	COG0321	lipoyl(octanoyl) transferase activity
RK21_RS27555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RK21_RS27560	COG1619	proteins homologs of microcin C7 resistance protein MccF
RK21_RS27565	COG2951	lytic endotransglycosylase activity
RK21_RS27585	COG0495	leucyl-tRNA aminoacylation
RK21_RS27600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RK21_RS27605	COG4535	Mg2 and Co2 transporter CorC
RK21_RS27610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RK21_RS27615	COG1702	phosphate starvation-inducible protein PhoH
RK21_RS27630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RK21_RS27635	COG0352	thiamine-phosphate diphosphorylase activity
RK21_RS27640	COG0351	phosphomethylpyrimidine kinase
RK21_RS27645	COG3850	Histidine kinase
RK21_RS27645	COG3437	response regulator, receiver
RK21_RS27645	COG2205	protein histidine kinase activity
RK21_RS27645	COG4999	Histidine kinase
RK21_RS27660	COG1960	acyl-CoA dehydrogenase activity
RK21_RS27665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RK21_RS27680	COG1522	sequence-specific DNA binding
RK21_RS27700	COG1643	Atp-dependent helicase
RK21_RS27715	COG3416	Protein conserved in bacteria
RK21_RS27725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK21_RS27730	COG1522	sequence-specific DNA binding
RK21_RS27735	COG0697	spore germination
RK21_RS27740	COG0513	Belongs to the DEAD box helicase family
RK21_RS27750	COG0123	including yeast histone deacetylase and acetoin utilization protein
RK21_RS27765	COG1946	Acyl-CoA thioesterase
RK21_RS27770	COG0546	phosphoglycolate phosphatase activity
RK21_RS27775	COG3321	synthase
RK21_RS27775	COG0604	alcohol dehydrogenase
RK21_RS27815	COG0582	viral genome integration into host DNA
RK21_RS27890	COG1484	DNA-dependent DNA replication
RK21_RS27895	COG0305	Participates in initiation and elongation during chromosome replication
RK21_RS27960	COG4626	Terminase
RK21_RS27960	COG1802	Transcriptional regulator
RK21_RS28095	COG1304	FMN binding
RK21_RS28100	COG1620	l-lactate permease
RK21_RS28110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RK21_RS28120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK21_RS28125	COG0735	belongs to the Fur family
RK21_RS28130	COG0497	DNA recombination
RK21_RS28135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RK21_RS28140	COG0443	Heat shock 70 kDa protein
RK21_RS28145	COG0484	heat shock protein binding
RK21_RS28150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RK21_RS28155	COG0505	Belongs to the CarA family
RK21_RS28160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RK21_RS28165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK21_RS28180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RK21_RS28190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RK21_RS28195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK21_RS28200	COG0149	triose-phosphate isomerase activity
RK21_RS28205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RK21_RS28220	COG0779	Required for maturation of 30S ribosomal subunits
RK21_RS28225	COG0195	Participates in both transcription termination and antitermination
RK21_RS28230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RK21_RS28235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RK21_RS28240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RK21_RS28245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RK21_RS28250	COG1185	polyribonucleotide nucleotidyltransferase activity
RK21_RS28255	COG2823	Periplasmic or secreted lipoprotein
RK21_RS28280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK21_RS28285	COG0166	Belongs to the GPI family
RK21_RS28290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RK21_RS28295	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RK21_RS28305	COG0617	tRNA 3'-terminal CCA addition
RK21_RS28315	COG4191	Histidine kinase
RK21_RS28325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK21_RS28335	COG0436	Aminotransferase
RK21_RS28340	COG1489	DNA binding
RK21_RS28350	COG4558	Periplasmic binding protein
RK21_RS28355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK21_RS28360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RK21_RS28380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK21_RS28390	COG3098	single-species biofilm formation
RK21_RS28395	COG0028	Belongs to the TPP enzyme family
RK21_RS28405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RK21_RS28410	COG1183	phosphatidylcholine synthase activity
RK21_RS28415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RK21_RS28420	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RK21_RS28455	COG5002	protein histidine kinase activity
RK21_RS28460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RK21_RS28530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding