locus-tag	class	description
L483_RS00010	COG0408	coproporphyrinogen oxidase activity
L483_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS00020	COG0659	secondary active sulfate transmembrane transporter activity
L483_RS00030	COG3119	arylsulfatase activity
L483_RS00050	COG0159	tryptophan synthase activity
L483_RS00055	COG0133	tryptophan synthase activity
L483_RS00070	COG3360	Dodecin
L483_RS00080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS00085	COG1764	response to oxidative stress
L483_RS00115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L483_RS00120	COG0339	signal peptide processing
L483_RS00125	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L483_RS00140	COG0659	secondary active sulfate transmembrane transporter activity
L483_RS00150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L483_RS00155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L483_RS00160	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L483_RS00185	COG1612	heme a metabolic process
L483_RS00190	COG0109	protoheme IX farnesyltransferase activity
L483_RS00205	COG2011	ABC-type metal ion transport system permease component
L483_RS00210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L483_RS00225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L483_RS00230	COG1121	(ABC) transporter
L483_RS00235	COG0735	belongs to the Fur family
L483_RS00240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
L483_RS00260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L483_RS00265	COG3245	cytochrome
L483_RS00275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L483_RS00290	COG3023	N-Acetylmuramoyl-L-alanine amidase
L483_RS00295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L483_RS00300	COG5002	protein histidine kinase activity
L483_RS00305	COG2204	response regulator
L483_RS00335	COG1301	dicarboxylic acid transport
L483_RS00340	COG0700	Nucleoside recognition
L483_RS00355	COG1127	ABC transporter
L483_RS00360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L483_RS00375	COG1283	sodium-dependent phosphate transmembrane transporter activity
L483_RS00380	COG0861	Integral membrane protein TerC family
L483_RS00385	COG2851	Citrate transporter
L483_RS00420	COG0427	acetyl-CoA hydrolase
L483_RS00440	COG0583	DNA-binding transcription factor activity
L483_RS00445	COG1960	acyl-CoA dehydrogenase activity
L483_RS00480	COG3712	iron ion homeostasis
L483_RS00490	COG1802	Transcriptional regulator
L483_RS00500	COG5001	Diguanylate cyclase
L483_RS00500	COG3300	MHYT domain
L483_RS00505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS00525	COG2175	clavaminate synthase activity
L483_RS00540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS00560	COG1289	transmembrane transporter activity
L483_RS00570	COG1566	PFAM secretion protein HlyD family protein
L483_RS00595	COG0672	)-iron permease
L483_RS00610	COG0625	glutathione transferase activity
L483_RS00615	COG0165	Argininosuccinate lyase
L483_RS00625	COG0181	hydroxymethylbilane synthase activity
L483_RS00645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L483_RS00670	COG0488	(ABC) transporter
L483_RS00680	COG1280	lysine exporter protein (LysE YggA)
L483_RS00710	COG0517	IMP dehydrogenase activity
L483_RS00710	COG0516	GMP reductase activity
L483_RS00725	COG2188	Transcriptional regulator
L483_RS00730	COG1053	succinate dehydrogenase
L483_RS00745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS00770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS00775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS00790	COG4771	TonB-dependent receptor
L483_RS00800	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS00805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L483_RS00815	COG2199	diguanylate cyclase activity
L483_RS00830	COG2011	ABC-type metal ion transport system permease component
L483_RS00835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L483_RS00840	COG1464	Belongs to the NlpA lipoprotein family
L483_RS00860	COG1126	abc transporter atp-binding protein
L483_RS00865	COG0765	amino acid transport
L483_RS00870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS00875	COG1045	serine acetyltransferase
L483_RS00880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS00885	COG2175	clavaminate synthase activity
L483_RS00890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS00895	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L483_RS00900	COG4521	taurine ABC transporter
L483_RS00910	COG0450	alkyl hydroperoxide reductase
L483_RS00915	COG0431	NADPH-dependent FMN reductase
L483_RS00920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS00930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS00935	COG1116	anion transmembrane transporter activity
L483_RS00950	COG2918	glutathione biosynthetic process
L483_RS00960	COG2183	response to ionizing radiation
L483_RS00975	COG0189	ligase activity
L483_RS00980	COG0189	ligase activity
L483_RS00980	COG4067	protein conserved in archaea
L483_RS00985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L483_RS00995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L483_RS01000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L483_RS01015	COG0243	molybdopterin cofactor binding
L483_RS01020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L483_RS01025	COG1652	LysM domain
L483_RS01030	COG1011	Hydrolase
L483_RS01035	COG0494	nUDIX hydrolase
L483_RS01065	COG2957	Belongs to the agmatine deiminase family
L483_RS01085	COG0069	glutamate synthase activity
L483_RS01110	COG2199	diguanylate cyclase activity
L483_RS01110	COG2203	Gaf domain
L483_RS01140	COG0582	viral genome integration into host DNA
L483_RS01350	COG4695	Portal protein
L483_RS01365	COG3617	BRO family, N-terminal domain
L483_RS01395	COG4215	(ABC) transporter
L483_RS01435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L483_RS01450	COG2223	nitrite transmembrane transporter activity
L483_RS01455	COG0131	Imidazoleglycerol-phosphate dehydratase
L483_RS01460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L483_RS01470	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L483_RS01475	COG0107	imidazoleglycerol-phosphate synthase activity
L483_RS01480	COG3448	diguanylate cyclase activity
L483_RS01480	COG4175	Glycine betaine
L483_RS01485	COG4176	ABC-type proline glycine betaine transport system permease component
L483_RS01495	COG1760	l-serine dehydratase
L483_RS01515	COG1250	3-hydroxyacyl-CoA dehydrogenase
L483_RS01520	COG3246	L-lysine catabolic process to acetate
L483_RS01550	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS01550	COG1902	pentaerythritol trinitrate reductase activity
L483_RS01555	COG0247	lactate metabolic process
L483_RS01555	COG2181	nitrate reductase activity
L483_RS01560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L483_RS01575	COG4638	Rieske (2fe-2S)
L483_RS01580	COG1017	nitric oxide dioxygenase activity
L483_RS01580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L483_RS01605	COG0840	transmembrane signaling receptor activity
L483_RS01615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L483_RS01645	COG1063	alcohol dehydrogenase
L483_RS01655	COG0531	amino acid
L483_RS01660	COG0204	Acyl-transferase
L483_RS01670	COG0745	RESPONSE REGULATOR receiver
L483_RS01675	COG2205	protein histidine kinase activity
L483_RS01680	COG4452	Inner membrane protein CreD
L483_RS01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L483_RS01710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L483_RS01725	COG0438	transferase activity, transferring glycosyl groups
L483_RS01765	COG4774	siderophore transport
L483_RS01770	COG3712	iron ion homeostasis
L483_RS01775	COG1595	DNA-templated transcription, initiation
L483_RS01780	COG2176	DNA-directed DNA polymerase activity
L483_RS01785	COG0517	IMP dehydrogenase activity
L483_RS01785	COG1125	glycine betaine transport
L483_RS01795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L483_RS01810	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L483_RS01815	COG3585	molybdate ion transport
L483_RS01815	COG2005	Transcriptional regulator
L483_RS01820	COG1040	competence protein
L483_RS01825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L483_RS01830	COG0156	8-amino-7-oxononanoate synthase activity
L483_RS01835	COG2267	carboxylic ester hydrolase activity
L483_RS01855	COG1960	acyl-CoA dehydrogenase activity
L483_RS01860	COG3706	GGDEF domain
L483_RS01865	COG1960	acyl-CoA dehydrogenase activity
L483_RS01870	COG0583	DNA-binding transcription factor activity
L483_RS01875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L483_RS01895	COG0535	radical SAM domain protein
L483_RS01905	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L483_RS01910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L483_RS01915	COG1025	Belongs to the peptidase M16 family
L483_RS01920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L483_RS01955	COG0358	DNA primase activity
L483_RS01960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L483_RS01965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L483_RS01970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L483_RS01975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L483_RS01985	COG0617	tRNA 3'-terminal CCA addition
L483_RS01990	COG2719	SpoVR family
L483_RS01995	COG2718	Belongs to the UPF0229 family
L483_RS02000	COG2766	serine protein kinase
L483_RS02005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L483_RS02010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L483_RS02015	COG2967	ApaG domain
L483_RS02020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L483_RS02025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L483_RS02030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L483_RS02035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L483_RS02040	COG3178	'Phosphotransferase
L483_RS02045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L483_RS02050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L483_RS02065	COG2197	response regulator
L483_RS02070	COG3842	ATPase activity
L483_RS02080	COG1176	ABC-type spermidine putrescine transport system, permease component I
L483_RS02090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L483_RS02095	COG0546	phosphoglycolate phosphatase activity
L483_RS02100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L483_RS02105	COG4625	pathogenesis
L483_RS02105	COG3240	lipase activity
L483_RS02110	COG0512	Glutamine amidotransferase of anthranilate synthase
L483_RS02115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L483_RS02120	COG0134	indole-3-glycerol-phosphate synthase activity
L483_RS02135	COG1765	OsmC-like protein
L483_RS02145	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L483_RS02150	COG0537	adenosine 5'-monophosphoramidase activity
L483_RS02155	COG0300	oxidoreductase activity
L483_RS02160	COG2070	2-Nitropropane dioxygenase
L483_RS02165	COG1981	membrane
L483_RS02170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L483_RS02175	COG0316	Belongs to the HesB IscA family
L483_RS02180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L483_RS02185	COG0739	heme binding
L483_RS02190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L483_RS02210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L483_RS02210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L483_RS02215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L483_RS02240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L483_RS02260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L483_RS02265	COG0081	regulation of translation
L483_RS02270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L483_RS02275	COG0222	ribosome binding
L483_RS02280	COG0085	RNA polymerase activity
L483_RS02285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L483_RS02290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L483_RS02295	COG0049	tRNA binding
L483_RS02300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L483_RS02305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L483_RS02310	COG0051	transcription antitermination factor activity, RNA binding
L483_RS02315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L483_RS02320	COG0088	Forms part of the polypeptide exit tunnel
L483_RS02325	COG0089	rRNA binding
L483_RS02330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L483_RS02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L483_RS02340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L483_RS02345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L483_RS02350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L483_RS02355	COG0255	Belongs to the universal ribosomal protein uL29 family
L483_RS02360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L483_RS02365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L483_RS02370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L483_RS02375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L483_RS02380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L483_RS02385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L483_RS02390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L483_RS02395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L483_RS02400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L483_RS02405	COG1841	ribosomal large subunit assembly
L483_RS02410	COG0200	Binds to the 23S rRNA
L483_RS02420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L483_RS02425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L483_RS02430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L483_RS02435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L483_RS02440	COG0202	RNA polymerase activity
L483_RS02445	COG0203	ribosomal protein L17
L483_RS02450	COG0753	catalase activity
L483_RS02455	COG2193	ferroxidase activity
L483_RS02460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L483_RS02465	COG2814	Major facilitator Superfamily
L483_RS02470	COG0629	single-stranded DNA binding
L483_RS02495	COG0419	ATPase involved in DNA repair
L483_RS02525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS02535	COG0730	response to heat
L483_RS02540	COG4221	oxidoreductase activity
L483_RS02545	COG0243	molybdopterin cofactor binding
L483_RS02545	COG3383	formate dehydrogenase (NAD+) activity
L483_RS02550	COG3383	formate dehydrogenase (NAD+) activity
L483_RS02550	COG0243	molybdopterin cofactor binding
L483_RS02555	COG0437	4 iron, 4 sulfur cluster binding
L483_RS02560	COG2864	formate dehydrogenase
L483_RS02565	COG3058	Necessary for formate dehydrogenase activity
L483_RS02570	COG1921	L-seryl-tRNASec selenium transferase activity
L483_RS02575	COG3276	selenocysteine insertion sequence binding
L483_RS02585	COG0252	asparaginase activity
L483_RS02590	COG1115	amino acid carrier protein
L483_RS02625	COG2814	Major facilitator Superfamily
L483_RS02630	COG3047	cAMP biosynthetic process
L483_RS02660	COG3118	belongs to the thioredoxin family
L483_RS02665	COG2264	protein methyltransferase activity
L483_RS02675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L483_RS02680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L483_RS02680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L483_RS02695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L483_RS02700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L483_RS02705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L483_RS02710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L483_RS02720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L483_RS02730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L483_RS02735	COG4206	TonB-dependent receptor
L483_RS02740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L483_RS02745	COG0142	geranyltranstransferase activity
L483_RS02750	COG1722	exodeoxyribonuclease VII activity
L483_RS02755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L483_RS02760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L483_RS02765	COG2819	hydrolase of the alpha beta superfamily
L483_RS02795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L483_RS02800	COG3228	Belongs to the MtfA family
L483_RS02805	COG0586	Pfam SNARE associated Golgi protein
L483_RS02810	COG0456	acetyltransferase
L483_RS02815	COG4302	ethanolamine ammonia-lyase activity
L483_RS02820	COG4303	Ethanolamine ammonia lyase large subunit
L483_RS02825	COG0531	amino acid
L483_RS02835	COG3284	Transcriptional regulator
L483_RS02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L483_RS02855	COG0702	epimerase
L483_RS02865	COG1063	alcohol dehydrogenase
L483_RS02875	COG0022	dehydrogenase e1 component
L483_RS02880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L483_RS02885	COG3199	ATP-NAD kinase
L483_RS02890	COG3284	Transcriptional regulator
L483_RS02905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L483_RS02935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L483_RS02940	COG0023	Translation Initiation Factor
L483_RS02945	COG1166	arginine decarboxylase activity
L483_RS02955	COG0534	Mate efflux family protein
L483_RS02960	COG2373	Large extracellular alpha-helical protein
L483_RS02970	COG4953	penicillin-binding protein 1C
L483_RS02975	COG2831	hemolysin activation secretion protein
L483_RS03000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L483_RS03010	COG2030	dehydratase
L483_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS03025	COG2207	Transcriptional regulator
L483_RS03040	COG2217	Heavy metal translocating P-type atpase
L483_RS03055	COG2814	Major facilitator Superfamily
L483_RS03065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L483_RS03070	COG0300	oxidoreductase activity
L483_RS03075	COG1739	Uncharacterized protein family UPF0029
L483_RS03080	COG1309	transcriptional regulator
L483_RS03125	COG2995	paraquat-inducible protein a
L483_RS03130	COG2995	paraquat-inducible protein a
L483_RS03135	COG3008	intermembrane lipid transfer
L483_RS03140	COG0268	Binds directly to 16S ribosomal RNA
L483_RS03150	COG0196	riboflavin kinase activity
L483_RS03155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L483_RS03160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L483_RS03165	COG1047	Peptidyl-prolyl cis-trans
L483_RS03170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L483_RS03200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS03225	COG0542	response to heat
L483_RS03255	COG1252	NADH dehydrogenase
L483_RS03280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L483_RS03285	COG0237	dephospho-CoA kinase activity
L483_RS03345	COG0039	L-malate dehydrogenase activity
L483_RS03350	COG0765	amino acid transport
L483_RS03355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS03365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS03385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L483_RS03400	COG0488	(ABC) transporter
L483_RS03405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L483_RS03410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L483_RS03430	COG1067	ATP-dependent peptidase activity
L483_RS03440	COG2862	Uncharacterized protein family, UPF0114
L483_RS03450	COG0545	Peptidyl-prolyl cis-trans isomerase
L483_RS03460	COG2824	Alkylphosphonate utilization operon protein PhnA
L483_RS03465	COG0142	geranyltranstransferase activity
L483_RS03470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L483_RS03475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L483_RS03480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L483_RS03485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L483_RS03490	COG3045	CreA protein
L483_RS03515	COG0456	acetyltransferase
L483_RS03545	COG2223	nitrite transmembrane transporter activity
L483_RS03560	COG1595	DNA-templated transcription, initiation
L483_RS03570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L483_RS03570	COG2169	Transcriptional regulator
L483_RS03575	COG1511	domain protein
L483_RS03575	COG3264	Mechanosensitive ion channel
L483_RS03600	COG1335	isochorismatase
L483_RS03620	COG0193	aminoacyl-tRNA hydrolase activity
L483_RS03625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L483_RS03630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L483_RS03640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L483_RS03645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L483_RS03660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L483_RS03665	COG3848	Pyruvate phosphate dikinase
L483_RS03665	COG0574	Belongs to the PEP-utilizing enzyme family
L483_RS03670	COG0574	Belongs to the PEP-utilizing enzyme family
L483_RS03670	COG3848	Pyruvate phosphate dikinase
L483_RS03690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L483_RS03695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L483_RS03705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L483_RS03710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L483_RS03725	COG0415	Belongs to the DNA photolyase family
L483_RS03730	COG0789	Transcriptional regulator
L483_RS03740	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
L483_RS03745	COG1090	epimerase
L483_RS03750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L483_RS03760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L483_RS03765	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L483_RS03780	COG0579	oxidoreductase
L483_RS03820	COG2135	peptidase activity
L483_RS03835	COG2119	membrane
L483_RS03840	COG2813	Specifically methylates the guanine in position
L483_RS03845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L483_RS03850	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS03880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L483_RS03885	COG2885	chlorophyll binding
L483_RS03890	COG0857	belongs to the CobB CobQ family
L483_RS03890	COG0280	phosphate acetyltransferase
L483_RS03900	COG0386	Belongs to the glutathione peroxidase family
L483_RS03915	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
L483_RS03920	COG0492	ferredoxin-NADP+ reductase activity
L483_RS03935	COG3023	N-Acetylmuramoyl-L-alanine amidase
L483_RS03940	COG3725	Membrane protein required for beta-lactamase induction
L483_RS03945	COG0084	hydrolase, TatD family'
L483_RS03950	COG1609	Transcriptional regulator
L483_RS03955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L483_RS03955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L483_RS03960	COG1105	Belongs to the carbohydrate kinase PfkB family
L483_RS03965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L483_RS03965	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L483_RS03965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L483_RS03970	COG3530	Putative quorum-sensing-regulated virulence factor
L483_RS03980	COG2203	Gaf domain
L483_RS03980	COG3706	GGDEF domain
L483_RS03980	COG4251	negative regulation of phosphorylation
L483_RS03980	COG5001	Diguanylate cyclase
L483_RS03995	COG5002	protein histidine kinase activity
L483_RS04005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L483_RS04055	COG3604	Transcriptional regulator
L483_RS04060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L483_RS04060	COG1017	nitric oxide dioxygenase activity
L483_RS04065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L483_RS04070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L483_RS04075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L483_RS04080	COG1845	cytochrome c oxidase, subunit III
L483_RS04085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L483_RS04090	COG0109	protoheme IX farnesyltransferase activity
L483_RS04095	COG0436	Aminotransferase
L483_RS04105	COG0727	PFAM Uncharacterised protein family (UPF0153)
L483_RS04120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L483_RS04135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L483_RS04140	COG0709	Synthesizes selenophosphate from selenide and ATP
L483_RS04145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
L483_RS04150	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L483_RS04155	COG3639	organic phosphonate transmembrane transporter activity
L483_RS04160	COG3639	organic phosphonate transmembrane transporter activity
L483_RS04165	COG3781	membrane
L483_RS04185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L483_RS04190	COG0343	queuine tRNA-ribosyltransferase activity
L483_RS04195	COG1862	Preprotein translocase
L483_RS04210	COG3134	Outer membrane lipoprotein
L483_RS04225	COG1045	serine acetyltransferase
L483_RS04235	COG1104	cysteine desulfurase activity
L483_RS04245	COG0316	Belongs to the HesB IscA family
L483_RS04250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L483_RS04255	COG0443	Heat shock 70 kDa protein
L483_RS04260	COG0633	Ferredoxin
L483_RS04270	COG0105	UTP biosynthetic process
L483_RS04275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L483_RS04290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L483_RS04295	COG0124	histidyl-tRNA synthetase
L483_RS04310	COG1160	GTP binding
L483_RS04315	COG0436	Aminotransferase
L483_RS04325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L483_RS04330	COG4774	siderophore transport
L483_RS04335	COG3128	pkhd-type hydroxylase
L483_RS04350	COG0019	diaminopimelate decarboxylase activity
L483_RS04365	COG4772	TonB-dependent receptor
L483_RS04390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L483_RS04405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L483_RS04420	COG4608	Belongs to the ABC transporter superfamily
L483_RS04425	COG0444	Belongs to the ABC transporter superfamily
L483_RS04430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L483_RS04435	COG0601	transmembrane transport
L483_RS04440	COG0747	negative chemotaxis
L483_RS04450	COG0747	negative chemotaxis
L483_RS04455	COG0747	negative chemotaxis
L483_RS04470	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
L483_RS04480	COG1113	amino acid transport
L483_RS04495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L483_RS04500	COG0154	amidase activity
L483_RS04505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L483_RS04510	COG1077	Cell shape determining protein MreB Mrl
L483_RS04515	COG1792	Involved in formation and maintenance of cell shape
L483_RS04525	COG0424	maF-like protein
L483_RS04540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L483_RS04545	COG0312	modulator of DNA gyrase
L483_RS04550	COG3028	Belongs to the UPF0307 family
L483_RS04555	COG0312	modulator of DNA gyrase
L483_RS04585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L483_RS04590	COG1660	Displays ATPase and GTPase activities
L483_RS04600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L483_RS04605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L483_RS04610	COG1137	ATPase activity
L483_RS04615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L483_RS04625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L483_RS04635	COG1127	ABC transporter
L483_RS04640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L483_RS04645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L483_RS04665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L483_RS04670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L483_RS04675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L483_RS04680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L483_RS04685	COG2186	Transcriptional regulator
L483_RS04690	COG2807	transmembrane transport
L483_RS04705	COG2827	Endonuclease containing a URI domain
L483_RS04710	COG3081	Nucleoid-associated protein
L483_RS04715	COG0776	regulation of translation
L483_RS04720	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
L483_RS04725	COG0525	valine-tRNA ligase activity
L483_RS04740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L483_RS04750	COG0795	lipopolysaccharide-transporting ATPase activity
L483_RS04755	COG0795	lipopolysaccharide-transporting ATPase activity
L483_RS04765	COG1278	Cold shock
L483_RS04770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L483_RS04775	COG1760	l-serine dehydratase
L483_RS04780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L483_RS04780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L483_RS04785	COG0509	glycine decarboxylation via glycine cleavage system
L483_RS04800	COG0786	glutamate:sodium symporter activity
L483_RS04820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L483_RS04825	COG2235	arginine
L483_RS04840	COG2832	Protein of unknown function (DUF454)
L483_RS04895	COG1653	transport
L483_RS04900	COG1175	transmembrane transport
L483_RS04910	COG3842	ATPase activity
L483_RS04920	COG0676	glucose-6-phosphate 1-epimerase activity
L483_RS04925	COG1737	Transcriptional regulator
L483_RS04940	COG0800	Aldolase
L483_RS04945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L483_RS04950	COG0739	heme binding
L483_RS04955	COG1570	exodeoxyribonuclease VII activity
L483_RS04960	COG0583	DNA-binding transcription factor activity
L483_RS04980	COG0519	Catalyzes the synthesis of GMP from XMP
L483_RS04980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L483_RS04990	COG0590	tRNA wobble adenosine to inosine editing
L483_RS04995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L483_RS05000	COG0047	phosphoribosylformylglycinamidine synthase activity
L483_RS05000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L483_RS05015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L483_RS05050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L483_RS05135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L483_RS05140	COG0477	Major facilitator Superfamily
L483_RS05145	COG4536	flavin adenine dinucleotide binding
L483_RS05155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L483_RS05160	COG0228	four-way junction DNA binding
L483_RS05165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L483_RS05170	COG0336	Belongs to the RNA methyltransferase TrmD family
L483_RS05175	COG0335	large ribosomal subunit rRNA binding
L483_RS05180	COG1607	acyl-coa hydrolase
L483_RS05185	COG4974	Belongs to the 'phage' integrase family
L483_RS05220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L483_RS05235	COG1902	pentaerythritol trinitrate reductase activity
L483_RS05240	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS05245	COG1177	transmembrane transport
L483_RS05250	COG1176	ABC-type spermidine putrescine transport system, permease component I
L483_RS05255	COG3842	ATPase activity
L483_RS05260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L483_RS05265	COG2979	Protein of unknown function (DUF533)
L483_RS05270	COG0840	transmembrane signaling receptor activity
L483_RS05280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L483_RS05280	COG0457	Tetratricopeptide repeat
L483_RS05295	COG2201	protein-glutamate methylesterase activity
L483_RS05300	COG2203	Gaf domain
L483_RS05300	COG3706	GGDEF domain
L483_RS05300	COG4251	negative regulation of phosphorylation
L483_RS05300	COG5001	Diguanylate cyclase
L483_RS05310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L483_RS05340	COG2885	chlorophyll binding
L483_RS05355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L483_RS05360	COG0563	adenylate kinase activity
L483_RS05395	COG0742	ribosomal rna small subunit methyltransferase
L483_RS05405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS05425	COG2937	Belongs to the GPAT DAPAT family
L483_RS05440	COG2226	methyltransferase
L483_RS05445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L483_RS05450	COG1215	transferase activity, transferring glycosyl groups
L483_RS05455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L483_RS05465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L483_RS05470	COG2171	N-acyltransferase activity
L483_RS05475	COG1393	Belongs to the ArsC family
L483_RS05485	COG0025	NhaP-type Na H and K H
L483_RS05490	COG0436	Aminotransferase
L483_RS05495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L483_RS05500	COG0024	Methionine aminopeptidase
L483_RS05505	COG0052	Belongs to the universal ribosomal protein uS2 family
L483_RS05510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L483_RS05515	COG0528	UMP kinase activity
L483_RS05520	COG0233	cytoplasmic translational termination
L483_RS05525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L483_RS05535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L483_RS05555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L483_RS05560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L483_RS05565	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L483_RS05570	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L483_RS05575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L483_RS05585	COG0825	malonyl-CoA metabolic process
L483_RS05590	COG0037	tRNA processing
L483_RS05595	COG0504	CTP synthase activity
L483_RS05600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L483_RS05605	COG0148	phosphopyruvate hydratase activity
L483_RS05615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L483_RS05625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L483_RS05635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L483_RS05640	COG0585	pseudouridine synthase activity
L483_RS05645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L483_RS05650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L483_RS05665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L483_RS05670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L483_RS05680	COG1546	Belongs to the CinA family
L483_RS05685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L483_RS05690	COG2137	regulation of response to DNA damage stimulus
L483_RS05710	COG3148	PFAM DTW domain containing protein
L483_RS05725	COG0583	DNA-binding transcription factor activity
L483_RS05735	COG3091	SprT-like family
L483_RS05745	COG0037	tRNA processing
L483_RS05765	COG1393	Belongs to the ArsC family
L483_RS05785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L483_RS05790	COG5002	protein histidine kinase activity
L483_RS05790	COG2205	protein histidine kinase activity
L483_RS05790	COG0784	Response regulator, receiver
L483_RS05810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L483_RS05815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L483_RS05820	COG3956	TIGRFAM MazG family protein
L483_RS05825	COG3122	Protein conserved in bacteria
L483_RS05840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L483_RS05845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L483_RS05855	COG0628	permease
L483_RS05865	COG0791	NLP P60 protein
L483_RS05870	COG0791	NLP P60 protein
L483_RS05885	COG1797	cobyrinic acid a,c-diamide synthase activity
L483_RS05890	COG0778	Nitroreductase
L483_RS05905	COG1492	cobalamin metabolic process
L483_RS05915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L483_RS05925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L483_RS05935	COG1846	Transcriptional regulator
L483_RS05960	COG0583	DNA-binding transcription factor activity
L483_RS05990	COG2205	protein histidine kinase activity
L483_RS05995	COG2814	Major facilitator Superfamily
L483_RS06000	COG0477	Major facilitator Superfamily
L483_RS06005	COG2076	Multidrug Resistance protein
L483_RS06010	COG0385	Bile acid
L483_RS06015	COG2974	May be involved in recombination
L483_RS06030	COG0024	Methionine aminopeptidase
L483_RS06035	COG0243	molybdopterin cofactor binding
L483_RS06040	COG2146	nitrite reductase [NAD(P)H] activity
L483_RS06040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L483_RS06045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L483_RS06045	COG2146	nitrite reductase [NAD(P)H] activity
L483_RS06050	COG0583	DNA-binding transcription factor activity
L483_RS06060	COG0545	Peptidyl-prolyl cis-trans isomerase
L483_RS06065	COG3339	Conserved Protein
L483_RS06080	COG3300	MHYT domain
L483_RS06080	COG5001	Diguanylate cyclase
L483_RS06110	COG1176	ABC-type spermidine putrescine transport system, permease component I
L483_RS06130	COG0668	transmembrane transport
L483_RS06135	COG1362	aminopeptidase activity
L483_RS06140	COG0564	pseudouridine synthase activity
L483_RS06145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L483_RS06150	COG2894	cell division
L483_RS06155	COG0850	regulation of cytokinetic process
L483_RS06160	COG1560	Kdo2-lipid A biosynthetic process
L483_RS06170	COG2853	Lipoprotein
L483_RS06190	COG2113	Glycine betaine
L483_RS06195	COG3162	membrane
L483_RS06200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L483_RS06220	COG3089	Belongs to the UPF0270 family
L483_RS06225	COG1363	Peptidase, m42
L483_RS06230	COG0189	ligase activity
L483_RS06230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L483_RS06235	COG0367	asparagine synthase
L483_RS06240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L483_RS06240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS06245	COG2326	polyphosphate kinase activity
L483_RS06250	COG0697	spore germination
L483_RS06255	COG0114	fumarate hydratase activity
L483_RS06265	COG0271	Belongs to the BolA IbaG family
L483_RS06270	COG1054	Belongs to the UPF0176 family
L483_RS06285	COG5001	Diguanylate cyclase
L483_RS06285	COG5002	protein histidine kinase activity
L483_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS06300	COG0546	phosphoglycolate phosphatase activity
L483_RS06305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L483_RS06310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L483_RS06320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L483_RS06330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L483_RS06335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L483_RS06345	COG0776	regulation of translation
L483_RS06355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L483_RS06365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L483_RS06380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L483_RS06395	COG0463	Glycosyl transferase, family 2
L483_RS06450	COG1083	cytidylyl-transferase
L483_RS06455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L483_RS06460	COG0438	transferase activity, transferring glycosyl groups
L483_RS06460	COG1216	Glycosyl transferase, family 2
L483_RS06485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS06495	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
L483_RS06505	COG0438	transferase activity, transferring glycosyl groups
L483_RS06520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L483_RS06535	COG0166	Belongs to the GPI family
L483_RS06540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L483_RS06545	COG1555	photosystem II stabilization
L483_RS06550	COG0284	orotidine-5'-phosphate decarboxylase activity
L483_RS06555	COG2130	NADP-dependent
L483_RS06570	COG3135	benzoate transporter
L483_RS06575	COG0625	glutathione transferase activity
L483_RS06585	COG0302	gtp cyclohydrolase
L483_RS06590	COG2840	Smr protein MutS2
L483_RS06620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L483_RS06625	COG2814	Major facilitator Superfamily
L483_RS06630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L483_RS06660	COG1368	sulfuric ester hydrolase activity
L483_RS06675	COG2010	Cytochrome c
L483_RS06675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L483_RS06680	COG0519	Catalyzes the synthesis of GMP from XMP
L483_RS06685	COG0598	Magnesium transport protein CorA
L483_RS06715	COG2814	Major facilitator Superfamily
L483_RS06720	COG0583	DNA-binding transcription factor activity
L483_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS06730	COG0583	DNA-binding transcription factor activity
L483_RS06750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L483_RS06755	COG1764	response to oxidative stress
L483_RS06760	COG1846	Transcriptional regulator
L483_RS06765	COG0583	DNA-binding transcription factor activity
L483_RS06775	COG0583	DNA-binding transcription factor activity
L483_RS06785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L483_RS06800	COG3384	dioxygenase
L483_RS06805	COG0500	methyltransferase
L483_RS06810	COG0501	Belongs to the peptidase M48B family
L483_RS06815	COG0436	Aminotransferase
L483_RS06820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L483_RS06825	COG0386	Belongs to the glutathione peroxidase family
L483_RS06830	COG4999	Histidine kinase
L483_RS06830	COG3850	Histidine kinase
L483_RS06830	COG3437	response regulator, receiver
L483_RS06830	COG2205	protein histidine kinase activity
L483_RS06840	COG1956	GAF domain-containing protein
L483_RS06870	COG3209	COG3209 Rhs family protein
L483_RS06895	COG3121	Chaperone
L483_RS06920	COG0625	glutathione transferase activity
L483_RS06925	COG1131	(ABC) transporter
L483_RS06930	COG0842	Transport permease protein
L483_RS06940	COG0658	competence protein
L483_RS06940	COG2333	competence protein COMEC
L483_RS06945	COG0811	peptide transport
L483_RS06950	COG0848	biopolymer transport protein
L483_RS06955	COG1663	tetraacyldisaccharide 4'-kinase activity
L483_RS06960	COG2835	tetraacyldisaccharide 4'-kinase activity
L483_RS06965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L483_RS06975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L483_RS06980	COG1530	ribonuclease E activity
L483_RS06990	COG0546	phosphoglycolate phosphatase activity
L483_RS06995	COG0616	signal peptide processing
L483_RS06995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L483_RS07000	COG0424	maF-like protein
L483_RS07010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L483_RS07015	COG0416	fatty acid biosynthetic process
L483_RS07020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L483_RS07030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L483_RS07035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L483_RS07045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L483_RS07050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L483_RS07060	COG0084	hydrolase, TatD family'
L483_RS07070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L483_RS07100	COG0556	nucleotide-excision repair
L483_RS07115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L483_RS07145	COG2267	carboxylic ester hydrolase activity
L483_RS07155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L483_RS07175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L483_RS07180	COG0066	3-isopropylmalate dehydratase activity
L483_RS07185	COG2226	methyltransferase
L483_RS07190	COG0473	3-isopropylmalate dehydrogenase activity
L483_RS07225	COG0135	phosphoribosylanthranilate isomerase activity
L483_RS07230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L483_RS07235	COG0285	dihydrofolate synthase activity
L483_RS07245	COG1286	toxin biosynthetic process
L483_RS07300	COG1902	pentaerythritol trinitrate reductase activity
L483_RS07300	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS07310	COG3038	cytochrome b561
L483_RS07320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L483_RS07325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L483_RS07330	COG0705	Rhomboid family
L483_RS07335	COG3139	Protein of unknown function (DUF1315)
L483_RS07345	COG0308	aminopeptidase N
L483_RS07365	COG2706	6-phosphogluconolactonase activity
L483_RS07385	COG0420	3'-5' exonuclease activity
L483_RS07415	COG0714	Associated with various cellular activities
L483_RS07430	COG3135	benzoate transporter
L483_RS07435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L483_RS07460	COG0583	DNA-binding transcription factor activity
L483_RS07465	COG2828	Protein conserved in bacteria
L483_RS07470	COG1301	dicarboxylic acid transport
L483_RS07475	COG2851	Citrate transporter
L483_RS07485	COG3237	CsbD-like
L483_RS07490	COG0789	Transcriptional regulator
L483_RS07500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L483_RS07505	COG2188	Transcriptional regulator
L483_RS07550	COG1595	DNA-templated transcription, initiation
L483_RS07555	COG0019	diaminopimelate decarboxylase activity
L483_RS07560	COG0583	DNA-binding transcription factor activity
L483_RS07575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L483_RS07590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L483_RS07605	COG0668	transmembrane transport
L483_RS07620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L483_RS07630	COG2223	nitrite transmembrane transporter activity
L483_RS07635	COG3707	response regulator
L483_RS07640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS07640	COG1116	anion transmembrane transporter activity
L483_RS07645	COG0167	dihydroorotate dehydrogenase activity
L483_RS07650	COG0116	Belongs to the methyltransferase superfamily
L483_RS07650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L483_RS07660	COG2027	D-alanyl-D-alanine carboxypeptidase
L483_RS07665	COG3171	Protein conserved in bacteria
L483_RS07675	COG2197	response regulator
L483_RS07700	COG0004	ammonium transporteR
L483_RS07725	COG0840	transmembrane signaling receptor activity
L483_RS07735	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
L483_RS07750	COG0425	Belongs to the sulfur carrier protein TusA family
L483_RS07755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L483_RS07760	COG1132	(ABC) transporter
L483_RS07780	COG0521	Mo-molybdopterin cofactor biosynthetic process
L483_RS07795	COG1597	lipid kinase activity
L483_RS07800	COG2197	response regulator
L483_RS07805	COG3851	Histidine kinase
L483_RS07815	COG0784	Response regulator, receiver
L483_RS07815	COG0835	chemotaxis
L483_RS07825	COG0741	lytic transglycosylase activity
L483_RS07830	COG0488	(ABC) transporter
L483_RS07835	COG0589	response to stress
L483_RS07845	COG1250	3-hydroxyacyl-CoA dehydrogenase
L483_RS07845	COG1024	Enoyl-CoA hydratase
L483_RS07850	COG0183	Belongs to the thiolase family
L483_RS07880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L483_RS07890	COG1376	ErfK ybiS ycfS ynhG family protein
L483_RS07900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L483_RS07910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L483_RS07920	COG1477	protein flavinylation
L483_RS07925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L483_RS07930	COG0584	glycerophosphoryl diester phosphodiesterase
L483_RS07940	COG4591	ABC-type transport system involved in lipoprotein release permease component
L483_RS07945	COG1136	(ABC) transporter
L483_RS07950	COG4591	ABC-type transport system involved in lipoprotein release permease component
L483_RS07970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L483_RS07970	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L483_RS07985	COG2853	Lipoprotein
L483_RS07995	COG4566	intracellular signal transduction
L483_RS08010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L483_RS08015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L483_RS08085	COG5532	Uncharacterized conserved protein (DUF2303)
L483_RS08205	COG4695	Portal protein
L483_RS08210	COG0740	serine-type endopeptidase activity
L483_RS08280	COG3642	lipopolysaccharide core region biosynthetic process
L483_RS08335	COG3685	Protein conserved in bacteria
L483_RS08340	COG2323	membrane
L483_RS08350	COG1058	Belongs to the CinA family
L483_RS08350	COG1546	Belongs to the CinA family
L483_RS08410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L483_RS08485	COG1953	Uracil, thiamine, allantoin
L483_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS08525	COG0583	DNA-binding transcription factor activity
L483_RS08535	COG0174	glutamine synthetase
L483_RS08540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L483_RS08605	COG3383	formate dehydrogenase (NAD+) activity
L483_RS08615	COG0589	response to stress
L483_RS08660	COG0010	Belongs to the arginase family
L483_RS08670	COG2133	pyrroloquinoline quinone binding
L483_RS08675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L483_RS08680	COG0596	Alpha beta hydrolase
L483_RS08685	COG1238	metal cluster binding
L483_RS08705	COG0826	peptidase U32
L483_RS08715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS08720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L483_RS08725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L483_RS08730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L483_RS08735	COG0583	DNA-binding transcription factor activity
L483_RS08740	COG2207	Transcriptional regulator
L483_RS08750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L483_RS08760	COG0183	Belongs to the thiolase family
L483_RS08765	COG1960	acyl-CoA dehydrogenase activity
L483_RS08770	COG1024	Enoyl-CoA hydratase
L483_RS08795	COG1320	monovalent cation:proton antiporter activity
L483_RS08800	COG2212	antiporter activity
L483_RS08810	COG0651	ATP synthesis coupled electron transport
L483_RS08815	COG1006	Multisubunit Na H antiporter MnhC subunit
L483_RS08820	COG2111	Na H antiporter
L483_RS08820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L483_RS08835	COG1335	isochorismatase
L483_RS08870	COG5006	permease, DMT superfamily
L483_RS08920	COG0183	Belongs to the thiolase family
L483_RS08925	COG1250	3-hydroxyacyl-CoA dehydrogenase
L483_RS08925	COG1024	Enoyl-CoA hydratase
L483_RS08930	COG1960	acyl-CoA dehydrogenase activity
L483_RS08935	COG2909	trisaccharide binding
L483_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS08970	COG2175	clavaminate synthase activity
L483_RS08985	COG2855	membrane
L483_RS09010	COG4447	cellulose binding
L483_RS09020	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS09025	COG3246	L-lysine catabolic process to acetate
L483_RS09030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L483_RS09060	COG0730	response to heat
L483_RS09065	COG0251	oxidation-reduction process
L483_RS09070	COG0840	transmembrane signaling receptor activity
L483_RS09075	COG0583	DNA-binding transcription factor activity
L483_RS09095	COG2186	Transcriptional regulator
L483_RS09105	COG0840	transmembrane signaling receptor activity
L483_RS09115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L483_RS09145	COG0544	peptidyl-prolyl cis-trans isomerase activity
L483_RS09150	COG0740	serine-type endopeptidase activity
L483_RS09155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L483_RS09160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L483_RS09170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L483_RS09200	COG0840	transmembrane signaling receptor activity
L483_RS09210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L483_RS09220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L483_RS09225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L483_RS09230	COG4181	ATPase activity
L483_RS09245	COG1388	LysM domain
L483_RS09245	COG1376	ErfK ybiS ycfS ynhG family protein
L483_RS09265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L483_RS09270	COG0589	response to stress
L483_RS09300	COG0189	ligase activity
L483_RS09300	COG4067	protein conserved in archaea
L483_RS09305	COG1802	Transcriptional regulator
L483_RS09315	COG0372	Belongs to the citrate synthase family
L483_RS09330	COG2079	MmgE PrpD family protein
L483_RS09345	COG0720	synthase
L483_RS09375	COG0517	IMP dehydrogenase activity
L483_RS09390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L483_RS09410	COG0745	RESPONSE REGULATOR receiver
L483_RS09415	COG4251	negative regulation of phosphorylation
L483_RS09455	COG2866	Carboxypeptidase
L483_RS09465	COG2365	Tyrosine phosphatase family
L483_RS09470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS09475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS09480	COG2207	Transcriptional regulator
L483_RS09485	COG2223	nitrite transmembrane transporter activity
L483_RS09530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L483_RS09535	COG0316	Belongs to the HesB IscA family
L483_RS09535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L483_RS09540	COG1999	signal sequence binding
L483_RS09595	COG0583	DNA-binding transcription factor activity
L483_RS09600	COG0583	DNA-binding transcription factor activity
L483_RS09605	COG2814	Major facilitator Superfamily
L483_RS09610	COG0417	DNA replication proofreading
L483_RS09625	COG2205	protein histidine kinase activity
L483_RS09650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS09655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L483_RS09675	COG0477	Major facilitator Superfamily
L483_RS09680	COG4774	siderophore transport
L483_RS09690	COG1192	Involved in chromosome partitioning
L483_RS09725	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L483_RS09730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L483_RS09745	COG4774	siderophore transport
L483_RS09760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L483_RS09790	COG2249	NAD(P)H dehydrogenase (quinone) activity
L483_RS09800	COG2207	Transcriptional regulator
L483_RS09805	COG1064	alcohol dehydrogenase
L483_RS09815	COG2814	Major facilitator Superfamily
L483_RS09830	COG0583	DNA-binding transcription factor activity
L483_RS09845	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS09850	COG0583	DNA-binding transcription factor activity
L483_RS09865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS09880	COG4106	trans-aconitate 2-methyltransferase activity
L483_RS09890	COG0583	DNA-binding transcription factor activity
L483_RS09900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS09905	COG0217	transcriptional regulatory protein
L483_RS09910	COG0583	DNA-binding transcription factor activity
L483_RS09915	COG0076	glutamate decarboxylase activity
L483_RS09925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L483_RS09925	COG1082	Xylose isomerase domain protein TIM barrel
L483_RS09935	COG1116	anion transmembrane transporter activity
L483_RS09940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS09945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS09950	COG4206	TonB-dependent receptor
L483_RS09955	COG4771	TonB-dependent receptor
L483_RS09970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS09975	COG1132	(ABC) transporter
L483_RS09980	COG1132	(ABC) transporter
L483_RS10000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS10005	COG0747	negative chemotaxis
L483_RS10015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L483_RS10025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS10040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS10055	COG3829	transcription factor binding
L483_RS10065	COG1595	DNA-templated transcription, initiation
L483_RS10075	COG4774	siderophore transport
L483_RS10090	COG3712	iron ion homeostasis
L483_RS10095	COG1595	DNA-templated transcription, initiation
L483_RS10110	COG0210	DNA helicase
L483_RS10125	COG0596	Alpha beta hydrolase
L483_RS10145	COG0477	Major facilitator Superfamily
L483_RS10155	COG0346	lactoylglutathione lyase activity
L483_RS10165	COG2995	paraquat-inducible protein a
L483_RS10180	COG1309	transcriptional regulator
L483_RS10185	COG2194	sulfuric ester hydrolase activity
L483_RS10225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L483_RS10230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS10250	COG4221	oxidoreductase activity
L483_RS10255	COG2233	PERMEase
L483_RS10270	COG0583	DNA-binding transcription factor activity
L483_RS10290	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L483_RS10300	COG0583	DNA-binding transcription factor activity
L483_RS10305	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS10310	COG0531	amino acid
L483_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS10330	COG1053	succinate dehydrogenase
L483_RS10340	COG0673	inositol 2-dehydrogenase activity
L483_RS10395	COG1053	succinate dehydrogenase
L483_RS10405	COG1053	succinate dehydrogenase
L483_RS10410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS10415	COG1414	Transcriptional regulator
L483_RS10420	COG1132	(ABC) transporter
L483_RS10425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L483_RS10445	COG1595	DNA-templated transcription, initiation
L483_RS10465	COG3459	Glycosyltransferase 36 associated
L483_RS10515	COG1309	transcriptional regulator
L483_RS10540	COG1522	sequence-specific DNA binding
L483_RS10555	COG2271	Major facilitator Superfamily
L483_RS10585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L483_RS10595	COG0581	inorganic phosphate transmembrane transporter activity
L483_RS10600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L483_RS10625	COG0784	Response regulator, receiver
L483_RS10625	COG2205	protein histidine kinase activity
L483_RS10645	COG1131	(ABC) transporter
L483_RS10715	COG0784	Response regulator, receiver
L483_RS10715	COG2205	protein histidine kinase activity
L483_RS10715	COG5002	protein histidine kinase activity
L483_RS10720	COG0583	DNA-binding transcription factor activity
L483_RS10725	COG3048	D-serine ammonia-lyase activity
L483_RS10730	COG2610	gluconate transmembrane transporter activity
L483_RS10745	COG1305	Transglutaminase-like
L483_RS10755	COG2308	Evidence 4 Homologs of previously reported genes of
L483_RS10760	COG0251	oxidation-reduction process
L483_RS10775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS10785	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS10805	COG0010	Belongs to the arginase family
L483_RS10810	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS10830	COG1113	amino acid transport
L483_RS10850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L483_RS10855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L483_RS10860	COG0678	peroxiredoxin activity
L483_RS10865	COG0583	DNA-binding transcription factor activity
L483_RS10880	COG1473	amidohydrolase
L483_RS10890	COG0708	Exodeoxyribonuclease III
L483_RS10895	COG0028	Belongs to the TPP enzyme family
L483_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS10915	COG0693	protein deglycase activity
L483_RS10920	COG1366	Belongs to the anti-sigma-factor antagonist family
L483_RS10925	COG1366	Belongs to the anti-sigma-factor antagonist family
L483_RS10930	COG2172	sigma factor antagonist activity
L483_RS10945	COG4191	Histidine kinase
L483_RS10945	COG0784	Response regulator, receiver
L483_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS10965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L483_RS10970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L483_RS10975	COG2080	2 iron, 2 sulfur cluster binding
L483_RS10995	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
L483_RS11005	COG0431	NADPH-dependent FMN reductase
L483_RS11015	COG0640	Transcriptional regulator
L483_RS11025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L483_RS11055	COG3220	belongs to the UPF0276 family
L483_RS11065	COG1595	DNA-templated transcription, initiation
L483_RS11070	COG4944	Protein of unknown function (DUF1109)
L483_RS11075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L483_RS11080	COG1063	alcohol dehydrogenase
L483_RS11105	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS11165	COG3046	protein related to deoxyribodipyrimidine photolyase
L483_RS11190	COG4221	oxidoreductase activity
L483_RS11200	COG1366	Belongs to the anti-sigma-factor antagonist family
L483_RS11205	COG0789	Transcriptional regulator
L483_RS11210	COG3158	transport of potassium into the cell
L483_RS11235	COG2271	Major facilitator Superfamily
L483_RS11240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L483_RS11245	COG0730	response to heat
L483_RS11255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L483_RS11260	COG1501	Belongs to the glycosyl hydrolase 31 family
L483_RS11315	COG1285	pathogenesis
L483_RS11325	COG0668	transmembrane transport
L483_RS11350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L483_RS11370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L483_RS11395	COG0392	lysyltransferase activity
L483_RS11400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L483_RS11405	COG3568	Endonuclease Exonuclease Phosphatase
L483_RS11430	COG1595	DNA-templated transcription, initiation
L483_RS11435	COG0693	protein deglycase activity
L483_RS11450	COG2205	protein histidine kinase activity
L483_RS11470	COG1063	alcohol dehydrogenase
L483_RS11470	COG1063	alcohol dehydrogenase
L483_RS11490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L483_RS11495	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L483_RS11500	COG2080	2 iron, 2 sulfur cluster binding
L483_RS11505	COG0028	Belongs to the TPP enzyme family
L483_RS11515	COG3300	MHYT domain
L483_RS11515	COG5001	Diguanylate cyclase
L483_RS11535	COG3387	PFAM Glycoside hydrolase 15-related
L483_RS11540	COG2323	membrane
L483_RS11550	COG1058	Belongs to the CinA family
L483_RS11550	COG1546	Belongs to the CinA family
L483_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS11590	COG1063	alcohol dehydrogenase
L483_RS11775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L483_RS11820	COG1192	Involved in chromosome partitioning
L483_RS11840	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS11845	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L483_RS11870	COG3039	Transposase
L483_RS11875	COG0582	viral genome integration into host DNA
L483_RS11885	COG0604	alcohol dehydrogenase
L483_RS11885	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS11885	COG3321	synthase
L483_RS11895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS11905	COG4948	Mandelate Racemase Muconate Lactonizing
L483_RS11915	COG0583	DNA-binding transcription factor activity
L483_RS11920	COG2721	sulfolactate sulfo-lyase activity
L483_RS11940	COG1199	ATP-dependent helicase activity
L483_RS11940	COG1199	ATP-dependent helicase activity
L483_RS11945	COG4974	Belongs to the 'phage' integrase family
L483_RS11950	COG0829	nickel cation binding
L483_RS11955	COG0831	urea catabolic process
L483_RS11960	COG0832	Belongs to the urease beta subunit family
L483_RS11965	COG0804	urea catabolic process
L483_RS11970	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
L483_RS11980	COG0830	nickel cation binding
L483_RS11985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L483_RS12040	COG0840	transmembrane signaling receptor activity
L483_RS12045	COG1968	undecaprenyl-diphosphatase activity
L483_RS12060	COG0583	DNA-binding transcription factor activity
L483_RS12065	COG0583	DNA-binding transcription factor activity
L483_RS12070	COG1475	DNA binding
L483_RS12110	COG1196	nuclear chromosome segregation
L483_RS12125	COG0210	DNA helicase
L483_RS12125	COG0210	DNA helicase
L483_RS12250	COG0515	serine threonine protein kinase
L483_RS12250	COG2815	serine threonine protein kinase
L483_RS12295	COG2801	Transposase and inactivated derivatives
L483_RS12300	COG2963	transposase activity
L483_RS12325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L483_RS12335	COG1902	pentaerythritol trinitrate reductase activity
L483_RS12335	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS12345	COG0235	Class ii aldolase
L483_RS12355	COG0393	Putative heavy-metal-binding
L483_RS12395	COG4221	oxidoreductase activity
L483_RS12410	COG1917	Cupin 2, conserved barrel domain protein
L483_RS12410	COG1396	sequence-specific DNA binding
L483_RS12415	COG0477	Major facilitator Superfamily
L483_RS12420	COG3038	cytochrome b561
L483_RS12430	COG1595	DNA-templated transcription, initiation
L483_RS12440	COG0708	Exodeoxyribonuclease III
L483_RS12450	COG0729	surface antigen
L483_RS12490	COG2366	antibiotic biosynthetic process
L483_RS12495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L483_RS12505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L483_RS12510	COG0215	cysteine-tRNA ligase activity
L483_RS12525	COG5002	protein histidine kinase activity
L483_RS12525	COG3850	Histidine kinase
L483_RS12530	COG0745	RESPONSE REGULATOR receiver
L483_RS12535	COG1802	Transcriptional regulator
L483_RS12545	COG0579	oxidoreductase
L483_RS12550	COG1113	amino acid transport
L483_RS12560	COG0113	porphobilinogen synthase activity
L483_RS12575	COG0307	riboflavin synthase, alpha
L483_RS12590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L483_RS12600	COG1984	allophanate hydrolase subunit 2
L483_RS12650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L483_RS12660	COG0463	Glycosyl transferase, family 2
L483_RS12685	COG0019	diaminopimelate decarboxylase activity
L483_RS12705	COG0625	glutathione transferase activity
L483_RS12720	COG0488	(ABC) transporter
L483_RS12880	COG3646	Phage regulatory protein
L483_RS13050	COG3642	lipopolysaccharide core region biosynthetic process
L483_RS13225	COG1253	flavin adenine dinucleotide binding
L483_RS13235	COG2200	EAL domain
L483_RS13255	COG4191	Histidine kinase
L483_RS13255	COG0784	Response regulator, receiver
L483_RS13280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS13290	COG3712	iron ion homeostasis
L483_RS13295	COG1595	DNA-templated transcription, initiation
L483_RS13315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS13320	COG1459	type II secretion system
L483_RS13330	COG1196	nuclear chromosome segregation
L483_RS13330	COG0741	lytic transglycosylase activity
L483_RS13330	COG0739	heme binding
L483_RS13335	COG5002	protein histidine kinase activity
L483_RS13340	COG2205	protein histidine kinase activity
L483_RS13360	COG3265	gluconokinase activity
L483_RS13365	COG1609	Transcriptional regulator
L483_RS13375	COG2205	protein histidine kinase activity
L483_RS13375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS13380	COG2197	response regulator
L483_RS13385	COG3813	Protein conserved in bacteria
L483_RS13415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS13420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS13430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L483_RS13435	COG0601	transmembrane transport
L483_RS13440	COG0747	negative chemotaxis
L483_RS13445	COG0235	Class ii aldolase
L483_RS13455	COG1960	acyl-CoA dehydrogenase activity
L483_RS13460	COG0583	DNA-binding transcription factor activity
L483_RS13465	COG1609	Transcriptional regulator
L483_RS13470	COG4771	TonB-dependent receptor
L483_RS13475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS13480	COG0667	Aldo Keto reductase
L483_RS13485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS13555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L483_RS13560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L483_RS13570	COG2271	Major facilitator Superfamily
L483_RS13630	COG1609	Transcriptional regulator
L483_RS13640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L483_RS13645	COG2271	Major facilitator Superfamily
L483_RS13655	COG2356	endonuclease I
L483_RS13665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L483_RS13670	COG0745	RESPONSE REGULATOR receiver
L483_RS13675	COG2205	protein histidine kinase activity
L483_RS13680	COG0667	Aldo Keto reductase
L483_RS13690	COG2814	Major facilitator Superfamily
L483_RS13695	COG1522	sequence-specific DNA binding
L483_RS13700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS13705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS13710	COG1126	abc transporter atp-binding protein
L483_RS13715	COG0765	amino acid transport
L483_RS13755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L483_RS13780	COG0642	Histidine kinase
L483_RS13790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L483_RS13805	COG0765	amino acid transport
L483_RS13810	COG0765	amino acid transport
L483_RS13815	COG1126	abc transporter atp-binding protein
L483_RS13830	COG2814	Major facilitator Superfamily
L483_RS13835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L483_RS13840	COG4569	acetaldehyde dehydrogenase (acetylating) activity
L483_RS13855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L483_RS13860	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS13895	COG1024	Enoyl-CoA hydratase
L483_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS13910	COG1960	acyl-CoA dehydrogenase activity
L483_RS13925	COG1960	acyl-CoA dehydrogenase activity
L483_RS13930	COG1960	acyl-CoA dehydrogenase activity
L483_RS13935	COG1960	acyl-CoA dehydrogenase activity
L483_RS13950	COG1902	pentaerythritol trinitrate reductase activity
L483_RS13950	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS13960	COG2814	Major facilitator Superfamily
L483_RS13980	COG1902	pentaerythritol trinitrate reductase activity
L483_RS13985	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS14025	COG1024	Enoyl-CoA hydratase
L483_RS14035	COG1024	Enoyl-CoA hydratase
L483_RS14040	COG1960	acyl-CoA dehydrogenase activity
L483_RS14045	COG1960	acyl-CoA dehydrogenase activity
L483_RS14050	COG0183	Belongs to the thiolase family
L483_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS14070	COG0183	Belongs to the thiolase family
L483_RS14095	COG0300	oxidoreductase activity
L483_RS14110	COG4191	Histidine kinase
L483_RS14110	COG0784	Response regulator, receiver
L483_RS14125	COG2721	sulfolactate sulfo-lyase activity
L483_RS14130	COG2271	Major facilitator Superfamily
L483_RS14150	COG0477	Major facilitator Superfamily
L483_RS14175	COG0346	lactoylglutathione lyase activity
L483_RS14190	COG1846	Transcriptional regulator
L483_RS14195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L483_RS14230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L483_RS14230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L483_RS14240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L483_RS14245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L483_RS14275	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS14310	COG0583	DNA-binding transcription factor activity
L483_RS14315	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS14320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS14325	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L483_RS14340	COG3039	Transposase
L483_RS14365	COG2433	Pfam Transposase IS66
L483_RS14380	COG1454	alcohol dehydrogenase
L483_RS14430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L483_RS14435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L483_RS14435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L483_RS14455	COG0583	DNA-binding transcription factor activity
L483_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS14490	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS14490	COG3321	synthase
L483_RS14490	COG0604	alcohol dehydrogenase
L483_RS14505	COG2918	glutathione biosynthetic process
L483_RS14530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L483_RS14545	COG0346	lactoylglutathione lyase activity
L483_RS14575	COG3039	Transposase
L483_RS14595	COG4644	lycopene metabolic process
L483_RS14610	COG4644	lycopene metabolic process
L483_RS14630	COG0681	Belongs to the peptidase S26 family
L483_RS14755	COG4974	Belongs to the 'phage' integrase family
L483_RS14785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L483_RS14845	COG2974	May be involved in recombination
L483_RS14850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L483_RS14925	COG0681	Belongs to the peptidase S26 family
L483_RS14965	COG3344	reverse transcriptase
L483_RS14975	COG2433	Pfam Transposase IS66
L483_RS15040	COG0551	DNA topoisomerase type I activity
L483_RS15040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L483_RS15065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L483_RS15070	COG1192	Involved in chromosome partitioning
L483_RS15075	COG1475	DNA binding
L483_RS15170	COG0210	DNA helicase
L483_RS15305	COG3039	Transposase
L483_RS15370	COG0305	Participates in initiation and elongation during chromosome replication
L483_RS15375	COG0305	Participates in initiation and elongation during chromosome replication
L483_RS15435	COG0789	Transcriptional regulator
L483_RS15510	COG1403	HNH endonuclease
L483_RS15520	COG2433	Pfam Transposase IS66
L483_RS15640	COG1230	cation diffusion facilitator family transporter
L483_RS15655	COG0640	Transcriptional regulator
L483_RS15660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L483_RS15665	COG0798	PFAM Bile acid sodium symporter
L483_RS15670	COG0431	NADPH-dependent FMN reductase
L483_RS15680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L483_RS15760	COG0463	Glycosyl transferase, family 2
L483_RS15810	COG2194	sulfuric ester hydrolase activity
L483_RS15825	COG1403	HNH endonuclease
L483_RS15900	COG3091	SprT-like family
L483_RS15930	COG2974	May be involved in recombination
L483_RS16005	COG2217	Heavy metal translocating P-type atpase
L483_RS16010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L483_RS16015	COG1074	ATP-dependent DNA helicase activity
L483_RS16050	COG2132	Multicopper oxidase
L483_RS16085	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L483_RS16090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS16115	COG4644	lycopene metabolic process
L483_RS16140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L483_RS16180	COG1802	Transcriptional regulator
L483_RS16185	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS16200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L483_RS16210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L483_RS16220	COG4774	siderophore transport
L483_RS16225	COG3712	iron ion homeostasis
L483_RS16235	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L483_RS16280	COG0625	glutathione transferase activity
L483_RS16285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L483_RS16315	COG2169	Transcriptional regulator
L483_RS16315	COG1917	Cupin 2, conserved barrel domain protein
L483_RS16360	COG1522	sequence-specific DNA binding
L483_RS16365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L483_RS16370	COG0508	dehydrogenase complex catalyzes the overall conversion of
L483_RS16375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L483_RS16390	COG3344	reverse transcriptase
L483_RS16395	COG0604	alcohol dehydrogenase
L483_RS16395	COG3321	synthase
L483_RS16405	COG3039	Transposase
L483_RS16425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L483_RS16430	COG0066	3-isopropylmalate dehydratase activity
L483_RS16435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L483_RS16445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L483_RS16450	COG0583	DNA-binding transcription factor activity
L483_RS16465	COG2814	Major facilitator Superfamily
L483_RS16470	COG3473	Maleate cis-trans isomerase
L483_RS16475	COG0583	DNA-binding transcription factor activity
L483_RS16495	COG3385	transposase activity
L483_RS16515	COG2963	transposase activity
L483_RS16520	COG2801	Transposase and inactivated derivatives
L483_RS16530	COG1111	helicase
L483_RS16530	COG1205	dead DEAH box helicase
L483_RS16545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L483_RS16585	COG0004	ammonium transporteR
L483_RS16590	COG0069	glutamate synthase activity
L483_RS16595	COG2218	PFAM glutamate synthase alpha subunit domain protein
L483_RS16600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L483_RS16620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L483_RS16635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L483_RS16635	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS16680	COG1024	Enoyl-CoA hydratase
L483_RS16700	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS16710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L483_RS16715	COG0523	cobalamin synthesis protein
L483_RS16750	COG2353	YceI-like domain
L483_RS16755	COG2353	YceI-like domain
L483_RS16760	COG3038	cytochrome b561
L483_RS16765	COG0583	DNA-binding transcription factor activity
L483_RS16780	COG3038	cytochrome b561
L483_RS16790	COG2814	Major facilitator Superfamily
L483_RS16795	COG0655	NAD(P)H dehydrogenase (quinone) activity
L483_RS16800	COG1741	Belongs to the pirin family
L483_RS16870	COG0668	transmembrane transport
L483_RS16875	COG3327	negative regulation of DNA-templated transcription, initiation
L483_RS16885	COG1024	Enoyl-CoA hydratase
L483_RS16890	COG1024	Enoyl-CoA hydratase
L483_RS16895	COG1250	3-hydroxyacyl-CoA dehydrogenase
L483_RS16900	COG2050	protein possibly involved in aromatic compounds catabolism
L483_RS16905	COG0183	Belongs to the thiolase family
L483_RS16915	COG3396	Phenylacetate-CoA oxygenase
L483_RS16920	COG3460	Phenylacetate-CoA oxygenase
L483_RS16925	COG3396	Phenylacetate-CoA oxygenase
L483_RS16930	COG2151	metal-sulfur cluster biosynthetic enzyme
L483_RS16935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L483_RS16940	COG3162	membrane
L483_RS16955	COG2030	dehydratase
L483_RS16955	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS16965	COG1063	alcohol dehydrogenase
L483_RS16975	COG0494	nUDIX hydrolase
L483_RS16990	COG3568	Endonuclease Exonuclease Phosphatase
L483_RS17000	COG0392	lysyltransferase activity
L483_RS17025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L483_RS17045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L483_RS17050	COG2890	protein-(glutamine-N5) methyltransferase activity
L483_RS17075	COG0667	Aldo Keto reductase
L483_RS17080	COG2837	iron assimilation
L483_RS17135	COG3384	dioxygenase
L483_RS17150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L483_RS17155	COG2423	ornithine cyclodeaminase activity
L483_RS17160	COG0402	S-adenosylhomocysteine deaminase activity
L483_RS17170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L483_RS17175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L483_RS17190	COG1999	signal sequence binding
L483_RS17205	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS17210	COG0583	DNA-binding transcription factor activity
L483_RS17215	COG1929	Belongs to the glycerate kinase type-1 family
L483_RS17220	COG3835	regulator
L483_RS17225	COG2271	Major facilitator Superfamily
L483_RS17235	COG0667	Aldo Keto reductase
L483_RS17240	COG1902	pentaerythritol trinitrate reductase activity
L483_RS17245	COG1278	Cold shock
L483_RS17270	COG3135	benzoate transporter
L483_RS17275	COG3485	protocatechuate 3,4-dioxygenase
L483_RS17280	COG2814	Major facilitator Superfamily
L483_RS17345	COG0583	DNA-binding transcription factor activity
L483_RS17350	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS17365	COG0174	glutamine synthetase
L483_RS17375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS17385	COG1760	l-serine dehydratase
L483_RS17390	COG0583	DNA-binding transcription factor activity
L483_RS17395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L483_RS17410	COG0438	transferase activity, transferring glycosyl groups
L483_RS17415	COG2990	Protein conserved in bacteria
L483_RS17420	COG1215	transferase activity, transferring glycosyl groups
L483_RS17460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L483_RS17485	COG1396	sequence-specific DNA binding
L483_RS17490	COG2031	fatty acid transporter
L483_RS17500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L483_RS17510	COG0656	L-ascorbic acid biosynthetic process
L483_RS17515	COG0587	DNA-directed DNA polymerase activity
L483_RS17530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L483_RS17555	COG1053	succinate dehydrogenase
L483_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS17570	COG1414	Transcriptional regulator
L483_RS17575	COG0154	amidase activity
L483_RS17585	COG1473	amidohydrolase
L483_RS17620	COG1881	PFAM PEBP family protein
L483_RS17625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L483_RS17630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L483_RS17640	COG4174	ABC transporter (Permease)
L483_RS17645	COG4239	(ABC) transporter, permease
L483_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS17655	COG4574	serine-type endopeptidase inhibitor activity
L483_RS17660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L483_RS17685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L483_RS17700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L483_RS17710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L483_RS17720	COG1215	transferase activity, transferring glycosyl groups
L483_RS17735	COG3706	GGDEF domain
L483_RS17740	COG2205	protein histidine kinase activity
L483_RS17745	COG0745	RESPONSE REGULATOR receiver
L483_RS17750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS17760	COG0746	molybdenum cofactor guanylyltransferase activity
L483_RS17765	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS17790	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS17810	COG1132	(ABC) transporter
L483_RS17815	COG3284	Transcriptional regulator
L483_RS17850	COG4968	Prepilin-type N-terminal cleavage methylation domain
L483_RS17860	COG4796	Type ii and iii secretion system protein
L483_RS17885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L483_RS17975	COG1960	acyl-CoA dehydrogenase activity
L483_RS17990	COG2384	SAM-dependent methyltransferase
L483_RS18000	COG0826	peptidase U32
L483_RS18005	COG2204	response regulator
L483_RS18045	COG0488	(ABC) transporter
L483_RS18050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L483_RS18060	COG0583	DNA-binding transcription factor activity
L483_RS18095	COG1309	transcriptional regulator
L483_RS18100	COG0697	spore germination
L483_RS18110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS18120	COG3257	ureidoglycine aminohydrolase activity
L483_RS18130	COG1113	amino acid transport
L483_RS18135	COG1522	sequence-specific DNA binding
L483_RS18140	COG2423	ornithine cyclodeaminase activity
L483_RS18150	COG0583	DNA-binding transcription factor activity
L483_RS18155	COG0405	Gamma-glutamyltransferase
L483_RS18170	COG2207	Transcriptional regulator
L483_RS18175	COG0789	Transcriptional regulator
L483_RS18185	COG1285	pathogenesis
L483_RS18195	COG0348	domain, Protein
L483_RS18200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS18210	COG4191	Histidine kinase
L483_RS18210	COG0784	Response regulator, receiver
L483_RS18215	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS18220	COG2814	Major facilitator Superfamily
L483_RS18225	COG1566	PFAM secretion protein HlyD family protein
L483_RS18230	COG1846	Transcriptional regulator
L483_RS18235	COG4566	intracellular signal transduction
L483_RS18245	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS18250	COG1960	acyl-CoA dehydrogenase activity
L483_RS18260	COG2056	Na+-H+ antiporter family
L483_RS18265	COG0840	transmembrane signaling receptor activity
L483_RS18275	COG4176	ABC-type proline glycine betaine transport system permease component
L483_RS18280	COG0583	DNA-binding transcription factor activity
L483_RS18305	COG1280	lysine exporter protein (LysE YggA)
L483_RS18310	COG2814	Major facilitator Superfamily
L483_RS18315	COG0583	DNA-binding transcription factor activity
L483_RS18340	COG2072	flavoprotein involved in K transport
L483_RS18355	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS18360	COG2271	Major facilitator Superfamily
L483_RS18375	COG4774	siderophore transport
L483_RS18380	COG3712	iron ion homeostasis
L483_RS18385	COG1595	DNA-templated transcription, initiation
L483_RS18435	COG0814	amino acid
L483_RS18460	COG4215	(ABC) transporter
L483_RS18470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS18475	COG1126	abc transporter atp-binding protein
L483_RS18480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L483_RS18485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L483_RS18490	COG2271	Major facilitator Superfamily
L483_RS18495	COG2721	sulfolactate sulfo-lyase activity
L483_RS18500	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS18505	COG2186	Transcriptional regulator
L483_RS18520	COG2391	methyltransferase activity
L483_RS18535	COG4335	DNA alkylation repair
L483_RS18580	COG1944	ATP diphosphatase activity
L483_RS18620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS18635	COG4991	sh3 domain protein
L483_RS18650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L483_RS18660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L483_RS18665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L483_RS18670	COG1116	anion transmembrane transporter activity
L483_RS18695	COG1959	2 iron, 2 sulfur cluster binding
L483_RS18715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L483_RS18725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L483_RS18735	COG2267	carboxylic ester hydrolase activity
L483_RS18740	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS18750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L483_RS18755	COG2186	Transcriptional regulator
L483_RS18760	COG2816	NAD+ diphosphatase activity
L483_RS18765	COG0784	Response regulator, receiver
L483_RS18765	COG4191	Histidine kinase
L483_RS18780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L483_RS18785	COG0069	glutamate synthase activity
L483_RS18790	COG2218	PFAM glutamate synthase alpha subunit domain protein
L483_RS18795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L483_RS18810	COG3920	Histidine kinase
L483_RS18830	COG2855	membrane
L483_RS18835	COG1611	Belongs to the LOG family
L483_RS18840	COG3300	MHYT domain
L483_RS18840	COG5001	Diguanylate cyclase
L483_RS18845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L483_RS18855	COG0477	Major facilitator Superfamily
L483_RS18865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L483_RS18875	COG0656	L-ascorbic acid biosynthetic process
L483_RS18880	COG5001	Diguanylate cyclase
L483_RS18890	COG3485	protocatechuate 3,4-dioxygenase
L483_RS18895	COG4829	muconolactone delta-isomerase
L483_RS18900	COG4948	Mandelate Racemase Muconate Lactonizing
L483_RS18910	COG1113	amino acid transport
L483_RS18920	COG1522	sequence-specific DNA binding
L483_RS18925	COG0583	DNA-binding transcription factor activity
L483_RS18945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L483_RS18965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L483_RS18970	COG2249	NAD(P)H dehydrogenase (quinone) activity
L483_RS18985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L483_RS18995	COG0045	succinate-CoA ligase (ADP-forming) activity
L483_RS19000	COG1960	acyl-CoA dehydrogenase activity
L483_RS19005	COG1024	Enoyl-CoA hydratase
L483_RS19010	COG0833	amino acid
L483_RS19035	COG1024	Enoyl-CoA hydratase
L483_RS19045	COG0577	efflux transmembrane transporter activity
L483_RS19050	COG4181	ATPase activity
L483_RS19085	COG0768	penicillin binding
L483_RS19105	COG0559	Belongs to the binding-protein-dependent transport system permease family
L483_RS19115	COG2186	Transcriptional regulator
L483_RS19120	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS19125	COG0028	Belongs to the TPP enzyme family
L483_RS19135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L483_RS19140	COG0436	Aminotransferase
L483_RS19155	COG4221	oxidoreductase activity
L483_RS19160	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS19165	COG1309	transcriptional regulator
L483_RS19205	COG2186	Transcriptional regulator
L483_RS19210	COG0277	FAD linked oxidase domain protein
L483_RS19215	COG0277	FAD linked oxidase domain protein
L483_RS19220	COG0247	lactate metabolic process
L483_RS19225	COG3193	protein, possibly involved in utilization of glycolate and propanediol
L483_RS19230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L483_RS19245	COG2807	transmembrane transport
L483_RS19250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L483_RS19260	COG0183	Belongs to the thiolase family
L483_RS19265	COG1250	3-hydroxyacyl-CoA dehydrogenase
L483_RS19275	COG2205	protein histidine kinase activity
L483_RS19275	COG2198	Histidine kinase
L483_RS19275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS19275	COG0784	Response regulator, receiver
L483_RS19280	COG2205	protein histidine kinase activity
L483_RS19280	COG3850	Histidine kinase
L483_RS19280	COG4999	Histidine kinase
L483_RS19280	COG3437	response regulator, receiver
L483_RS19290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L483_RS19295	COG0784	Response regulator, receiver
L483_RS19295	COG2198	Histidine kinase
L483_RS19295	COG2205	protein histidine kinase activity
L483_RS19330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS19385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L483_RS19395	COG1686	Belongs to the peptidase S11 family
L483_RS19435	COG1121	(ABC) transporter
L483_RS19480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L483_RS19485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS19495	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS19495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L483_RS19510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L483_RS19520	COG1176	ABC-type spermidine putrescine transport system, permease component I
L483_RS19525	COG1177	transmembrane transport
L483_RS19530	COG3842	ATPase activity
L483_RS19535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L483_RS19540	COG0861	Integral membrane protein TerC family
L483_RS19565	COG1104	cysteine desulfurase activity
L483_RS19570	COG5654	RES domain protein
L483_RS19575	COG5642	Protein of unknown function (DUF2384)
L483_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS19600	COG0625	glutathione transferase activity
L483_RS19605	COG2814	Major facilitator Superfamily
L483_RS19610	COG0583	DNA-binding transcription factor activity
L483_RS19630	COG2814	Major facilitator Superfamily
L483_RS19645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L483_RS19650	COG1960	acyl-CoA dehydrogenase activity
L483_RS19655	COG0183	Belongs to the thiolase family
L483_RS19660	COG1022	Amp-dependent synthetase and ligase
L483_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS19670	COG1024	Enoyl-CoA hydratase
L483_RS19685	COG1231	oxidoreductase activity
L483_RS19710	COG2873	o-acetylhomoserine
L483_RS19730	COG0667	Aldo Keto reductase
L483_RS19755	COG2066	Belongs to the glutaminase family
L483_RS19760	COG0697	spore germination
L483_RS19765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS19780	COG3384	dioxygenase
L483_RS19785	COG0583	DNA-binding transcription factor activity
L483_RS19790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L483_RS19795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L483_RS19800	COG2828	Protein conserved in bacteria
L483_RS19810	COG0302	gtp cyclohydrolase
L483_RS19815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L483_RS19860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L483_RS20035	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
L483_RS20340	COG3846	protein secretion by the type IV secretion system
L483_RS20355	COG3451	type IV secretory pathway VirB4
L483_RS20365	COG3838	Conjugal transfer protein Trbc
L483_RS20370	COG4962	Type ii secretion system protein e
L483_RS20400	COG2076	Multidrug Resistance protein
L483_RS20410	COG0583	DNA-binding transcription factor activity
L483_RS20445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L483_RS20450	COG1127	ABC transporter
L483_RS20515	COG5489	Protein of unknown function (DUF736)
L483_RS20540	COG2003	Belongs to the UPF0758 family
L483_RS20545	COG4804	nuclease activity
L483_RS20665	COG5532	Uncharacterized conserved protein (DUF2303)
L483_RS20745	COG0582	viral genome integration into host DNA
L483_RS20760	COG0776	regulation of translation
L483_RS20765	COG0072	phenylalanine-tRNA ligase activity
L483_RS20770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L483_RS20775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L483_RS20780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L483_RS20785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L483_RS20790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L483_RS20800	COG1278	Cold shock
L483_RS20820	COG1869	D-ribose catabolic process
L483_RS20825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L483_RS20830	COG1609	Transcriptional regulator
L483_RS20835	COG1172	Belongs to the binding-protein-dependent transport system permease family
L483_RS20840	COG1129	ABC transporter
L483_RS20850	COG0252	asparaginase activity
L483_RS20855	COG4772	TonB-dependent receptor
L483_RS20870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L483_RS20880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L483_RS20885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L483_RS20890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L483_RS20895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L483_RS20960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS20970	COG1253	flavin adenine dinucleotide binding
L483_RS20980	COG0583	DNA-binding transcription factor activity
L483_RS20985	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L483_RS20990	COG3132	Protein of unknown function, DUF480
L483_RS21000	COG3634	alkyl hydroperoxide reductase activity
L483_RS21015	COG3344	reverse transcriptase
L483_RS21025	COG3258	Cytochrome c
L483_RS21030	COG2863	cytochrome
L483_RS21060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L483_RS21070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L483_RS21080	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
L483_RS21085	COG0784	Response regulator, receiver
L483_RS21085	COG4191	Histidine kinase
L483_RS21100	COG2259	Doxx family
L483_RS21110	COG1064	alcohol dehydrogenase
L483_RS21120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L483_RS21130	COG2135	peptidase activity
L483_RS21160	COG0616	signal peptide processing
L483_RS21180	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS21185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L483_RS21215	COG0490	domain, Protein
L483_RS21215	COG0471	metal ion transport
L483_RS21220	COG2199	diguanylate cyclase activity
L483_RS21250	COG2271	Major facilitator Superfamily
L483_RS21255	COG1335	isochorismatase
L483_RS21260	COG3473	Maleate cis-trans isomerase
L483_RS21265	COG0596	Alpha beta hydrolase
L483_RS21270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L483_RS21275	COG2309	aminopeptidase activity
L483_RS21280	COG1846	Transcriptional regulator
L483_RS21285	COG2080	2 iron, 2 sulfur cluster binding
L483_RS21290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L483_RS21290	COG2010	Cytochrome c
L483_RS21295	COG1309	transcriptional regulator
L483_RS21320	COG4608	Belongs to the ABC transporter superfamily
L483_RS21325	COG0444	Belongs to the ABC transporter superfamily
L483_RS21330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L483_RS21335	COG0747	negative chemotaxis
L483_RS21340	COG0601	transmembrane transport
L483_RS21345	COG0747	negative chemotaxis
L483_RS21350	COG4948	Mandelate Racemase Muconate Lactonizing
L483_RS21360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L483_RS21380	COG0583	DNA-binding transcription factor activity
L483_RS21385	COG0840	transmembrane signaling receptor activity
L483_RS21395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L483_RS21415	COG0583	DNA-binding transcription factor activity
L483_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS21435	COG0477	Major facilitator Superfamily
L483_RS21460	COG1473	amidohydrolase
L483_RS21465	COG2807	transmembrane transport
L483_RS21480	COG3842	ATPase activity
L483_RS21485	COG1177	transmembrane transport
L483_RS21490	COG1176	ABC-type spermidine putrescine transport system, permease component I
L483_RS21495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L483_RS21515	COG2508	Transcriptional regulator
L483_RS21575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS21605	COG1192	Involved in chromosome partitioning
L483_RS21650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L483_RS21710	COG1595	DNA-templated transcription, initiation
L483_RS21715	COG3712	iron ion homeostasis
L483_RS21720	COG4774	siderophore transport
L483_RS21730	COG0668	transmembrane transport
L483_RS21735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L483_RS21740	COG2358	TRAP transporter, solute receptor (TAXI family
L483_RS21755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS21760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L483_RS21910	COG2233	PERMEase
L483_RS21930	COG2920	part of a sulfur-relay system
L483_RS21935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L483_RS21940	COG0435	Glutathione S-transferase
L483_RS21945	COG1648	precorrin-2 dehydrogenase activity
L483_RS21945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L483_RS21950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L483_RS21955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L483_RS21960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L483_RS21965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L483_RS21970	COG1674	ftsk spoiiie
L483_RS21975	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L483_RS21980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L483_RS21985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L483_RS21990	COG0542	response to heat
L483_RS21995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L483_RS22000	COG1278	Cold shock
L483_RS22020	COG0482	sulfurtransferase activity
L483_RS22025	COG2915	High frequency lysogenization protein hflD homolog
L483_RS22035	COG2850	peptidyl-arginine hydroxylation
L483_RS22040	COG2153	protein acetylation
L483_RS22050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS22065	COG2816	NAD+ diphosphatase activity
L483_RS22070	COG1024	Enoyl-CoA hydratase
L483_RS22075	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L483_RS22080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L483_RS22085	COG3040	lipid binding
L483_RS22095	COG1234	tRNA 3'-trailer cleavage
L483_RS22110	COG1953	Uracil, thiamine, allantoin
L483_RS22115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L483_RS22130	COG1309	transcriptional regulator
L483_RS22140	COG3387	PFAM Glycoside hydrolase 15-related
L483_RS22145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L483_RS22150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L483_RS22155	COG0297	glycogen (starch) synthase activity
L483_RS22160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L483_RS22165	COG1640	4-alpha-glucanotransferase
L483_RS22185	COG3568	Endonuclease Exonuclease Phosphatase
L483_RS22195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L483_RS22200	COG0366	Alpha amylase catalytic
L483_RS22210	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS22215	COG1960	acyl-CoA dehydrogenase activity
L483_RS22220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L483_RS22250	COG0583	DNA-binding transcription factor activity
L483_RS22295	COG0179	Fumarylacetoacetate (FAA) hydrolase
L483_RS22300	COG3971	2-oxopent-4-enoate hydratase activity
L483_RS22310	COG0477	Major facilitator Superfamily
L483_RS22315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L483_RS22330	COG1414	Transcriptional regulator
L483_RS22355	COG0322	excinuclease ABC activity
L483_RS22375	COG3189	MarR family transcriptional regulator
L483_RS22380	COG0306	phosphate transporter
L483_RS22385	COG0625	glutathione transferase activity
L483_RS22390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L483_RS22390	COG2050	protein possibly involved in aromatic compounds catabolism
L483_RS22395	COG1113	amino acid transport
L483_RS22400	COG0583	DNA-binding transcription factor activity
L483_RS22405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L483_RS22420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L483_RS22425	COG0659	secondary active sulfate transmembrane transporter activity
L483_RS22460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L483_RS22465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L483_RS22470	COG0649	NAD binding
L483_RS22470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L483_RS22485	COG1034	ATP synthesis coupled electron transport
L483_RS22490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L483_RS22495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L483_RS22505	COG0713	ATP synthesis coupled electron transport
L483_RS22520	COG1007	ATP synthesis coupled electron transport
L483_RS22555	COG0431	NADPH-dependent FMN reductase
L483_RS22575	COG0328	RNA-DNA hybrid ribonuclease activity
L483_RS22585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L483_RS22590	COG1388	LysM domain
L483_RS22590	COG0741	lytic transglycosylase activity
L483_RS22600	COG4166	transmembrane transport
L483_RS22605	COG4166	transmembrane transport
L483_RS22610	COG4174	ABC transporter (Permease)
L483_RS22615	COG4239	(ABC) transporter, permease
L483_RS22620	COG4172	Belongs to the ABC transporter superfamily
L483_RS22630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L483_RS22640	COG0583	DNA-binding transcription factor activity
L483_RS22645	COG0745	RESPONSE REGULATOR receiver
L483_RS22650	COG2205	protein histidine kinase activity
L483_RS22655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L483_RS22665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L483_RS22675	COG0628	permease
L483_RS22710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L483_RS22725	COG2205	protein histidine kinase activity
L483_RS22725	COG4999	Histidine kinase
L483_RS22725	COG3850	Histidine kinase
L483_RS22725	COG3437	response regulator, receiver
L483_RS22730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L483_RS22745	COG1741	Belongs to the pirin family
L483_RS22755	COG0326	Molecular chaperone. Has ATPase activity
L483_RS22790	COG0045	succinate-CoA ligase (ADP-forming) activity
L483_RS22795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L483_RS22815	COG1053	succinate dehydrogenase
L483_RS22820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L483_RS22825	COG2009	succinate dehydrogenase
L483_RS22850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS22855	COG3047	cAMP biosynthetic process
L483_RS22855	COG2885	chlorophyll binding
L483_RS22885	COG2944	sequence-specific DNA binding
L483_RS22895	COG0477	Major facilitator Superfamily
L483_RS22915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS22920	COG0577	efflux transmembrane transporter activity
L483_RS22920	COG1136	(ABC) transporter
L483_RS22925	COG1538	Outer membrane efflux protein
L483_RS22945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L483_RS22965	COG0657	acetylesterase activity
L483_RS22995	COG0642	Histidine kinase
L483_RS23015	COG2010	Cytochrome c
L483_RS23035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L483_RS23085	COG3123	guanosine phosphorylase activity
L483_RS23095	COG3278	Belongs to the heme-copper respiratory oxidase family
L483_RS23110	COG2010	Cytochrome c
L483_RS23115	COG3278	Belongs to the heme-copper respiratory oxidase family
L483_RS23130	COG2010	Cytochrome c
L483_RS23135	COG0348	domain, Protein
L483_RS23145	COG2217	Heavy metal translocating P-type atpase
L483_RS23165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L483_RS23170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L483_RS23175	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L483_RS23180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L483_RS23185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L483_RS23200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L483_RS23205	COG3115	cell septum assembly
L483_RS23235	COG0402	S-adenosylhomocysteine deaminase activity
L483_RS23240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L483_RS23250	COG2252	PERMEase
L483_RS23270	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L483_RS23280	COG2233	PERMEase
L483_RS23295	COG1368	sulfuric ester hydrolase activity
L483_RS23300	COG2354	Protein conserved in bacteria
L483_RS23315	COG3960	tartronate-semialdehyde synthase activity
L483_RS23320	COG3622	Belongs to the hyi family
L483_RS23325	COG2084	Dehydrogenase
L483_RS23335	COG0469	pyruvate kinase activity
L483_RS23345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L483_RS23355	COG0668	transmembrane transport
L483_RS23360	COG0116	Belongs to the methyltransferase superfamily
L483_RS23360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L483_RS23370	COG1522	sequence-specific DNA binding
L483_RS23375	COG1953	Uracil, thiamine, allantoin
L483_RS23410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L483_RS23440	COG1138	Cytochrome C-type biogenesis protein
L483_RS23445	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L483_RS23465	COG4133	protoheme IX ABC transporter activity
L483_RS23475	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L483_RS23495	COG0835	chemotaxis
L483_RS23505	COG1192	Involved in chromosome partitioning
L483_RS23510	COG1360	Flagellar Motor Protein
L483_RS23515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L483_RS23520	COG2201	protein-glutamate methylesterase activity
L483_RS23525	COG2198	Histidine kinase
L483_RS23525	COG0643	Histidine kinase
L483_RS23525	COG0784	Response regulator, receiver
L483_RS23530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
L483_RS23555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L483_RS23570	COG1987	bacterial-type flagellum assembly
L483_RS23610	COG0745	RESPONSE REGULATOR receiver
L483_RS23645	COG1677	Flagellar hook-basal body complex protein FliE
L483_RS23660	COG1216	Glycosyl transferase, family 2
L483_RS23665	COG0463	Glycosyl transferase, family 2
L483_RS23665	COG1216	Glycosyl transferase, family 2
L483_RS23695	COG0028	Belongs to the TPP enzyme family
L483_RS23715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L483_RS23735	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L483_RS23740	COG1334	flagellar protein FlaG
L483_RS23750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L483_RS23760	COG4786	Flagellar basal body rod
L483_RS23760	COG1256	bacterial-type flagellum assembly
L483_RS23770	COG1706	bacterial-type flagellum-dependent cell motility
L483_RS23775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L483_RS23785	COG4787	bacterial-type flagellum-dependent cell motility
L483_RS23800	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L483_RS23810	COG1815	bacterial-type flagellum-dependent cell motility
L483_RS23815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L483_RS23820	COG0784	Response regulator, receiver
L483_RS23820	COG0835	chemotaxis
L483_RS23840	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
L483_RS23845	COG0477	Major facilitator Superfamily
L483_RS23855	COG1522	sequence-specific DNA binding
L483_RS23860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L483_RS23865	COG0022	dehydrogenase e1 component
L483_RS23875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L483_RS23880	COG3706	GGDEF domain
L483_RS23885	COG1802	Transcriptional regulator
L483_RS23895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L483_RS23920	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
L483_RS23930	COG2239	Acts as a magnesium transporter
L483_RS23955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L483_RS23960	COG0527	aspartate kinase activity
L483_RS23965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L483_RS23970	COG2988	succinylglutamate desuccinylase activity
L483_RS23980	COG3724	N-succinylarginine dihydrolase activity
L483_RS23985	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS24000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L483_RS24025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS24030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L483_RS24050	COG2154	pterin-4-alpha-carbinolamine dehydratase
L483_RS24055	COG2365	Tyrosine phosphatase family
L483_RS24065	COG0277	FAD linked oxidase domain protein
L483_RS24065	COG0247	lactate metabolic process
L483_RS24075	COG1113	amino acid transport
L483_RS24085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L483_RS24095	COG0009	L-threonylcarbamoyladenylate synthase
L483_RS24100	COG0613	PHP domain protein
L483_RS24105	COG2917	probably involved in intracellular septation
L483_RS24110	COG2350	Protein conserved in bacteria
L483_RS24115	COG0745	RESPONSE REGULATOR receiver
L483_RS24130	COG0778	Nitroreductase
L483_RS24135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L483_RS24155	COG2207	Transcriptional regulator
L483_RS24170	COG1752	Esterase of the alpha-beta hydrolase superfamily
L483_RS24180	COG0514	ATP-dependent DNA helicase (RecQ)
L483_RS24190	COG2832	Protein of unknown function (DUF454)
L483_RS24205	COG0840	transmembrane signaling receptor activity
L483_RS24225	COG0583	DNA-binding transcription factor activity
L483_RS24235	COG0697	spore germination
L483_RS24245	COG3657	addiction module killer protein
L483_RS24250	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L483_RS24260	COG0513	Belongs to the DEAD box helicase family
L483_RS24265	COG0668	transmembrane transport
L483_RS24270	COG0679	Auxin Efflux Carrier
L483_RS24280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L483_RS24295	COG2267	carboxylic ester hydrolase activity
L483_RS24305	COG1132	(ABC) transporter
L483_RS24315	COG2188	Transcriptional regulator
L483_RS24325	COG1643	Atp-dependent helicase
L483_RS24330	COG0174	glutamine synthetase
L483_RS24335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS24340	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS24345	COG0318	PFAM AMP-dependent synthetase and ligase
L483_RS24350	COG2267	carboxylic ester hydrolase activity
L483_RS24355	COG2030	dehydratase
L483_RS24360	COG4941	Belongs to the sigma-70 factor family
L483_RS24370	COG3795	YCII-related domain
L483_RS24390	COG0242	peptide deformylase activity
L483_RS24395	COG1295	ribonuclease BN
L483_RS24405	COG3420	alginic acid biosynthetic process
L483_RS24425	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L483_RS24455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L483_RS24475	COG1984	allophanate hydrolase subunit 2
L483_RS24480	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L483_RS24485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L483_RS24490	COG2814	Major facilitator Superfamily
L483_RS24505	COG0121	glutamine amidotransferase
L483_RS24545	COG2983	Belongs to the UPF0260 family
L483_RS24555	COG3100	YcgL domain-containing protein
L483_RS24575	COG0626	cystathionine gamma-synthase activity
L483_RS24580	COG1522	sequence-specific DNA binding
L483_RS24590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L483_RS24595	COG3781	membrane
L483_RS24605	COG0521	Mo-molybdopterin cofactor biosynthetic process
L483_RS24610	COG0583	DNA-binding transcription factor activity
L483_RS24620	COG0531	amino acid
L483_RS24625	COG3938	Belongs to the proline racemase family
L483_RS24630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L483_RS24645	COG1902	pentaerythritol trinitrate reductase activity
L483_RS24650	COG0640	Transcriptional regulator
L483_RS24655	COG0579	oxidoreductase
L483_RS24660	COG1595	DNA-templated transcription, initiation
L483_RS24725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L483_RS24730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L483_RS24735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
L483_RS24740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L483_RS24750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L483_RS24760	COG0425	Belongs to the sulfur carrier protein TusA family
L483_RS24770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L483_RS24780	COG0531	amino acid
L483_RS24785	COG0840	transmembrane signaling receptor activity
L483_RS24800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L483_RS24805	COG0602	queuosine metabolic process
L483_RS24810	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
L483_RS24815	COG2885	chlorophyll binding
L483_RS24820	COG0823	Involved in the tonB-independent uptake of proteins
L483_RS24840	COG0824	Thioesterase
L483_RS24845	COG2255	four-way junction helicase activity
L483_RS24850	COG0632	four-way junction helicase activity
L483_RS24855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L483_RS24860	COG0217	transcriptional regulatory protein
L483_RS24865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L483_RS24880	COG0783	Belongs to the Dps family
L483_RS24890	COG2900	Belongs to the SlyX family
L483_RS24905	COG0442	prolyl-tRNA aminoacylation
L483_RS24915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L483_RS24945	COG3158	transport of potassium into the cell
L483_RS24950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L483_RS24975	COG0519	Catalyzes the synthesis of GMP from XMP
L483_RS24985	COG4807	Protein conserved in bacteria
L483_RS24995	COG1301	dicarboxylic acid transport
L483_RS25025	COG2205	protein histidine kinase activity
L483_RS25030	COG0745	RESPONSE REGULATOR receiver
L483_RS25035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L483_RS25035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L483_RS25040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L483_RS25050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L483_RS25060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L483_RS25085	COG2271	Major facilitator Superfamily
L483_RS25090	COG0583	DNA-binding transcription factor activity
L483_RS25095	COG1017	nitric oxide dioxygenase activity
L483_RS25095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L483_RS25100	COG0625	glutathione transferase activity
L483_RS25105	COG3012	SEC-C Motif Domain Protein
L483_RS25105	COG3318	Belongs to the UPF0149 family
L483_RS25110	COG0252	asparaginase activity
L483_RS25120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L483_RS25150	COG2116	formate transmembrane transporter activity
L483_RS25155	COG3706	GGDEF domain
L483_RS25160	COG5001	Diguanylate cyclase
L483_RS25170	COG0583	DNA-binding transcription factor activity
L483_RS25175	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS25190	COG1289	transmembrane transporter activity
L483_RS25210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L483_RS25260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L483_RS25265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L483_RS25280	COG0259	pyridoxamine-phosphate oxidase activity
L483_RS25285	COG2885	chlorophyll binding
L483_RS25300	COG1199	ATP-dependent helicase activity
L483_RS25370	COG3012	SEC-C Motif Domain Protein
L483_RS25380	COG0653	protein targeting
L483_RS25390	COG2814	Major facilitator Superfamily
L483_RS25395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L483_RS25400	COG1045	serine acetyltransferase
L483_RS25405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS25410	COG2366	antibiotic biosynthetic process
L483_RS25415	COG1793	dna ligase
L483_RS25415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L483_RS25420	COG1793	dna ligase
L483_RS25430	COG1201	RNA secondary structure unwinding
L483_RS25445	COG0717	Belongs to the dCTP deaminase family
L483_RS25450	COG1278	Cold shock
L483_RS25455	COG0489	protein tyrosine kinase activity
L483_RS25460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L483_RS25460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L483_RS25475	COG4659	FMN binding
L483_RS25485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L483_RS25495	COG2197	response regulator
L483_RS25505	COG0137	argininosuccinate synthase activity
L483_RS25515	COG0418	dihydroorotase activity
L483_RS25520	COG0450	alkyl hydroperoxide reductase
L483_RS25540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L483_RS25545	COG0243	molybdopterin cofactor binding
L483_RS25550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L483_RS25555	COG3842	ATPase activity
L483_RS25560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L483_RS25570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L483_RS25595	COG0765	amino acid transport
L483_RS25600	COG0765	amino acid transport
L483_RS25605	COG1126	abc transporter atp-binding protein
L483_RS25625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L483_RS25630	COG0583	DNA-binding transcription factor activity
L483_RS25635	COG0494	nUDIX hydrolase
L483_RS25640	COG1201	RNA secondary structure unwinding
L483_RS25645	COG0069	glutamate synthase activity
L483_RS25650	COG1113	amino acid transport
L483_RS25660	COG1695	Transcriptional regulator
L483_RS25665	COG2375	cellular response to nickel ion
L483_RS25675	COG4628	conserved protein (DUF2132)
L483_RS25680	COG4206	TonB-dependent receptor
L483_RS25695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L483_RS25715	COG2226	methyltransferase
L483_RS25720	COG0500	methyltransferase
L483_RS25740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L483_RS25745	COG1381	Involved in DNA repair and RecF pathway recombination
L483_RS25750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L483_RS25755	COG0571	ribonuclease III activity
L483_RS25760	COG0681	Belongs to the peptidase S26 family
L483_RS25765	COG0481	GTPase activity
L483_RS25770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L483_RS25800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L483_RS25805	COG0354	folic acid binding
L483_RS25845	COG3180	Ammonia monooxygenase
L483_RS25850	COG0737	Belongs to the 5'-nucleotidase family
L483_RS25855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L483_RS25880	COG2267	carboxylic ester hydrolase activity
L483_RS25920	COG4191	Histidine kinase
L483_RS25930	COG0477	Major facilitator Superfamily
L483_RS25960	COG2207	Transcriptional regulator
L483_RS25970	COG0583	DNA-binding transcription factor activity
L483_RS25975	COG2910	NAD(P)H-binding
L483_RS25990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L483_RS25995	COG0477	Major facilitator Superfamily
L483_RS26000	COG1309	transcriptional regulator
L483_RS26005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS26010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L483_RS26035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L483_RS26040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L483_RS26045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L483_RS26050	COG0477	Major facilitator Superfamily
L483_RS26055	COG0183	Belongs to the thiolase family
L483_RS26060	COG2814	Major facilitator Superfamily
L483_RS26065	COG1414	Transcriptional regulator
L483_RS26075	COG0306	phosphate transporter
L483_RS26080	COG0433	COG0433 Predicted ATPase
L483_RS26085	COG0840	transmembrane signaling receptor activity
L483_RS26090	COG0438	transferase activity, transferring glycosyl groups
L483_RS26090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L483_RS26105	COG0788	formyltetrahydrofolate deformylase activity
L483_RS26115	COG2925	Exonuclease
L483_RS26130	COG0469	pyruvate kinase activity
L483_RS26160	COG0693	protein deglycase activity
L483_RS26210	COG1902	pentaerythritol trinitrate reductase activity
L483_RS26220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L483_RS26225	COG0583	DNA-binding transcription factor activity
L483_RS26235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L483_RS26275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS26280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L483_RS26285	COG2814	Major facilitator Superfamily
L483_RS26295	COG3642	lipopolysaccharide core region biosynthetic process
L483_RS26305	COG0642	Histidine kinase
L483_RS26320	COG0459	protein refolding
L483_RS26325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L483_RS26330	COG3030	protein affecting phage T7 exclusion by the F plasmid
L483_RS26360	COG0668	transmembrane transport
L483_RS26365	COG1666	GTP binding
L483_RS26380	COG2096	Adenosyltransferase
L483_RS26385	COG0352	thiamine-phosphate diphosphorylase activity
L483_RS26395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L483_RS26400	COG0653	protein targeting
L483_RS26420	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L483_RS26425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L483_RS26440	COG1181	Belongs to the D-alanine--D-alanine ligase family
L483_RS26445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L483_RS26450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L483_RS26455	COG0772	Belongs to the SEDS family
L483_RS26460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L483_RS26465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L483_RS26470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L483_RS26475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L483_RS26490	COG0275	rRNA processing
L483_RS26495	COG2001	Belongs to the MraZ family
L483_RS26505	COG3107	peptidoglycan biosynthetic process
L483_RS26510	COG0792	nuclease activity
L483_RS26515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L483_RS26520	COG2823	Periplasmic or secreted lipoprotein
L483_RS26530	COG2969	positive regulation of protein catabolic process
L483_RS26535	COG0625	glutathione transferase activity
L483_RS26540	COG2857	Cytochrome c1
L483_RS26545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L483_RS26550	COG0723	plastoquinol--plastocyanin reductase activity
L483_RS26555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L483_RS26560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L483_RS26565	COG0667	Aldo Keto reductase
L483_RS26575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L483_RS26580	COG0180	Tryptophanyl-tRNA synthetase
L483_RS26600	COG1522	sequence-specific DNA binding
L483_RS26625	COG0175	sulfate reduction
L483_RS26635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L483_RS26640	COG1126	abc transporter atp-binding protein
L483_RS26645	COG0765	amino acid transport
L483_RS26650	COG4597	amino acid ABC transporter
L483_RS26655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS26660	COG0400	carboxylic ester hydrolase activity
L483_RS26665	COG0513	Belongs to the DEAD box helicase family
L483_RS26675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L483_RS26680	COG0315	cyclic pyranopterin monophosphate synthase activity
L483_RS26685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L483_RS26695	COG3022	response to hydroperoxide
L483_RS26705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L483_RS26710	COG1215	transferase activity, transferring glycosyl groups
L483_RS26715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS26720	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
L483_RS26730	COG3420	alginic acid biosynthetic process
L483_RS26745	COG1696	Membrane protein involved in D-alanine export
L483_RS26760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
L483_RS26760	COG0662	Cupin 2, conserved barrel domain protein
L483_RS26770	COG0300	oxidoreductase activity
L483_RS26800	COG1566	PFAM secretion protein HlyD family protein
L483_RS26820	COG0583	DNA-binding transcription factor activity
L483_RS26825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L483_RS26830	COG0697	spore germination
L483_RS26835	COG3708	Transcriptional regulator
L483_RS26835	COG2207	Transcriptional regulator
L483_RS26870	COG1595	DNA-templated transcription, initiation
L483_RS26875	COG3712	iron ion homeostasis
L483_RS26880	COG4772	TonB-dependent receptor
L483_RS26905	COG4964	Belongs to the GSP D family
L483_RS26985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L483_RS27025	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L483_RS27035	COG1028	Short-chain dehydrogenase reductase Sdr
L483_RS27040	COG0596	Alpha beta hydrolase
L483_RS27045	COG1346	cytolysis
L483_RS27050	COG1380	Effector of murein hydrolase LrgA
L483_RS27055	COG0583	DNA-binding transcription factor activity
L483_RS27065	COG1366	Belongs to the anti-sigma-factor antagonist family
L483_RS27075	COG0789	Transcriptional regulator
L483_RS27105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L483_RS27130	COG2957	Belongs to the agmatine deiminase family
L483_RS27150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L483_RS27160	COG0523	cobalamin synthesis protein
L483_RS27165	COG2879	small protein
L483_RS27170	COG1966	Carbon starvation protein
L483_RS27180	COG2233	PERMEase
L483_RS27190	COG1970	mechanosensitive ion channel activity
L483_RS27200	COG2197	response regulator
L483_RS27205	COG2813	Specifically methylates the guanine in position
L483_RS27215	COG1294	oxidase, subunit
L483_RS27220	COG1271	oxidase subunit
L483_RS27230	COG2252	PERMEase
L483_RS27235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L483_RS27240	COG3485	protocatechuate 3,4-dioxygenase
L483_RS27245	COG3485	protocatechuate 3,4-dioxygenase
L483_RS27250	COG2321	neutral zinc metallopeptidase
L483_RS27255	COG0840	transmembrane signaling receptor activity
L483_RS27265	COG0583	DNA-binding transcription factor activity
L483_RS27270	COG2249	NAD(P)H dehydrogenase (quinone) activity
L483_RS27290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L483_RS27295	COG2267	carboxylic ester hydrolase activity
L483_RS27300	COG0671	phosphoesterase, PA-phosphatase related
L483_RS27300	COG2453	phosphatase
L483_RS27315	COG4589	Belongs to the CDS family
L483_RS27340	COG2885	chlorophyll binding
L483_RS27340	COG3047	cAMP biosynthetic process
L483_RS27345	COG2199	diguanylate cyclase activity
L483_RS27355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L483_RS27360	COG1074	ATP-dependent DNA helicase activity
L483_RS27365	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L483_RS27395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
L483_RS27400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L483_RS27405	COG1183	phosphatidylcholine synthase activity
L483_RS27410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L483_RS27420	COG0028	Belongs to the TPP enzyme family
L483_RS27425	COG3098	single-species biofilm formation
L483_RS27435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L483_RS27455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
L483_RS27460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L483_RS27465	COG4558	Periplasmic binding protein
L483_RS27475	COG1489	DNA binding
L483_RS27480	COG0436	Aminotransferase
L483_RS27490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L483_RS27500	COG4191	Histidine kinase
L483_RS27510	COG0617	tRNA 3'-terminal CCA addition
L483_RS27520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L483_RS27525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L483_RS27530	COG0166	Belongs to the GPI family
L483_RS27535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L483_RS27560	COG2823	Periplasmic or secreted lipoprotein
L483_RS27565	COG1185	polyribonucleotide nucleotidyltransferase activity
L483_RS27570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L483_RS27575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L483_RS27580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L483_RS27585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L483_RS27590	COG0195	Participates in both transcription termination and antitermination
L483_RS27595	COG0779	Required for maturation of 30S ribosomal subunits
L483_RS27610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L483_RS27615	COG0149	triose-phosphate isomerase activity
L483_RS27620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L483_RS27625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L483_RS27635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L483_RS27650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L483_RS27655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L483_RS27660	COG0505	Belongs to the CarA family
L483_RS27665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L483_RS27670	COG0484	heat shock protein binding
L483_RS27675	COG0443	Heat shock 70 kDa protein
L483_RS27680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L483_RS27685	COG0497	DNA recombination
L483_RS27690	COG0735	belongs to the Fur family
L483_RS27695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L483_RS27705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L483_RS27715	COG1620	l-lactate permease
L483_RS27720	COG1304	FMN binding
L483_RS27855	COG4626	Terminase
L483_RS27855	COG1802	Transcriptional regulator
L483_RS28000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L483_RS28030	COG0582	viral genome integration into host DNA
L483_RS28060	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
L483_RS28075	COG0765	amino acid transport
L483_RS28080	COG1126	abc transporter atp-binding protein
L483_RS28085	COG0006	proline dipeptidase activity
L483_RS28090	COG1902	pentaerythritol trinitrate reductase activity
L483_RS28090	COG0446	pyridine nucleotide-disulphide oxidoreductase
L483_RS28100	COG4774	siderophore transport
L483_RS28260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L483_RS28365	COG0604	alcohol dehydrogenase
L483_RS28365	COG3321	synthase
L483_RS28375	COG1946	Acyl-CoA thioesterase
L483_RS28390	COG0123	including yeast histone deacetylase and acetoin utilization protein
L483_RS28400	COG0513	Belongs to the DEAD box helicase family
L483_RS28405	COG0697	spore germination
L483_RS28410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L483_RS28420	COG3416	Protein conserved in bacteria
L483_RS28430	COG1643	Atp-dependent helicase
L483_RS28450	COG1522	sequence-specific DNA binding
L483_RS28465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L483_RS28470	COG1960	acyl-CoA dehydrogenase activity
L483_RS28500	COG2205	protein histidine kinase activity
L483_RS28500	COG3437	response regulator, receiver
L483_RS28500	COG3850	Histidine kinase
L483_RS28500	COG4999	Histidine kinase
L483_RS28505	COG0351	phosphomethylpyrimidine kinase
L483_RS28510	COG0352	thiamine-phosphate diphosphorylase activity
L483_RS28515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L483_RS28530	COG1702	phosphate starvation-inducible protein PhoH
L483_RS28535	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L483_RS28540	COG4535	Mg2 and Co2 transporter CorC
L483_RS28545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L483_RS28560	COG0495	leucyl-tRNA aminoacylation
L483_RS28580	COG2951	lytic endotransglycosylase activity
L483_RS28585	COG1619	proteins homologs of microcin C7 resistance protein MccF
L483_RS28590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L483_RS28595	COG0321	lipoyl(octanoyl) transferase activity
L483_RS28600	COG2921	Belongs to the UPF0250 family
L483_RS28605	COG1686	Belongs to the peptidase S11 family
L483_RS28615	COG2951	lytic endotransglycosylase activity
L483_RS28620	COG0772	Belongs to the SEDS family
L483_RS28625	COG0768	penicillin binding
L483_RS28630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L483_RS28640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L483_RS28645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L483_RS28655	COG0586	Pfam SNARE associated Golgi protein
L483_RS28665	COG1346	cytolysis
L483_RS28680	COG2264	protein methyltransferase activity
L483_RS28690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L483_RS28700	COG0138	bifunctional purine biosynthesis protein purh
L483_RS28705	COG0151	Belongs to the GarS family
L483_RS28715	COG2095	MarC family integral membrane protein
L483_RS28750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L483_RS28760	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
L483_RS28775	COG0330	HflC and HflK could
L483_RS28795	COG4774	siderophore transport
L483_RS28805	COG1113	amino acid transport
L483_RS28825	COG0411	ABC transporter
L483_RS28840	COG0789	Transcriptional regulator
L483_RS28845	COG0484	heat shock protein binding
L483_RS28850	COG0443	Heat shock 70 kDa protein
L483_RS28870	COG0697	spore germination
L483_RS28875	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L483_RS28890	COG2982	Protein involved in outer membrane biogenesis
L483_RS28910	COG4221	oxidoreductase activity
L483_RS28940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L483_RS28945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L483_RS28960	COG1032	radical SAM domain protein
L483_RS28975	COG5265	(ABC) transporter
L483_RS28980	COG0305	Participates in initiation and elongation during chromosome replication
L483_RS28985	COG0359	binds to the 23S rRNA
L483_RS28995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L483_RS29000	COG0360	Binds together with S18 to 16S ribosomal RNA
L483_RS29005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L483_RS29010	COG0557	exoribonuclease II activity
L483_RS29025	COG1840	ABC-type Fe3 transport system, periplasmic component
L483_RS29030	COG1178	ABC-type Fe3 transport system permease component
L483_RS29035	COG0840	transmembrane signaling receptor activity
L483_RS29040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L483_RS29045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L483_RS29050	COG0330	HflC and HflK could
L483_RS29055	COG0330	HflC and HflK could
L483_RS29060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L483_RS29065	COG1923	regulation of RNA biosynthetic process
L483_RS29070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L483_RS29075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L483_RS29080	COG0860	N-Acetylmuramoyl-L-alanine amidase
L483_RS29085	COG0802	atpase or kinase
L483_RS29090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L483_RS29090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L483_RS29100	COG2860	membrane
L483_RS29105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L483_RS29110	COG1162	GTPase activity
L483_RS29120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L483_RS29135	COG0688	phosphatidylethanolamine metabolic process
L483_RS29140	COG3830	Belongs to the UPF0237 family
L483_RS29140	COG0560	Phosphoserine phosphatase
L483_RS29160	COG3577	Aspartyl protease
L483_RS29175	COG3150	esterase
L483_RS29180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L483_RS29190	COG0494	nUDIX hydrolase
L483_RS29205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L483_RS29210	COG1538	Outer membrane efflux protein
L483_RS29215	COG1519	Transferase
L483_RS29240	COG0667	Aldo Keto reductase
L483_RS29250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L483_RS29250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L483_RS29255	COG1132	(ABC) transporter
L483_RS29270	COG0438	transferase activity, transferring glycosyl groups
L483_RS29295	COG0438	transferase activity, transferring glycosyl groups
L483_RS29300	COG2192	nodulation
L483_RS29305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L483_RS29315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L483_RS29320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L483_RS29320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L483_RS29320	COG0506	proline dehydrogenase activity
L483_RS29335	COG1960	acyl-CoA dehydrogenase activity
L483_RS29345	COG0312	modulator of DNA gyrase
L483_RS29350	COG0477	Major facilitator Superfamily
L483_RS29355	COG0513	Belongs to the DEAD box helicase family
L483_RS29360	COG2081	HI0933 family
L483_RS29365	COG1289	transmembrane transporter activity
L483_RS29370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS29375	COG2153	protein acetylation
L483_RS29385	COG1451	nucleotide metabolic process
L483_RS29410	COG0126	phosphoglycerate kinase activity
L483_RS29425	COG0640	Transcriptional regulator
L483_RS29430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L483_RS29435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L483_RS29475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L483_RS29480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L483_RS29495	COG0513	Belongs to the DEAD box helicase family
L483_RS29500	COG2353	YceI-like domain
L483_RS29505	COG3038	cytochrome b561
L483_RS29525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L483_RS29530	COG1272	protein, Hemolysin III
L483_RS29540	COG0643	Histidine kinase
L483_RS29540	COG0784	Response regulator, receiver
L483_RS29540	COG2198	Histidine kinase
L483_RS29565	COG0189	ligase activity
L483_RS29575	COG1678	Uncharacterized ACR, COG1678
L483_RS29580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L483_RS29585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L483_RS29590	COG0540	Belongs to the ATCase OTCase family
L483_RS29595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L483_RS29600	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L483_RS29605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L483_RS29655	COG2226	methyltransferase
L483_RS29665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L483_RS29670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L483_RS29675	COG0140	phosphoribosyl-ATP diphosphatase activity
L483_RS29680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L483_RS29700	COG0840	transmembrane signaling receptor activity
L483_RS29705	COG0840	transmembrane signaling receptor activity
L483_RS29710	COG1126	abc transporter atp-binding protein
L483_RS29715	COG0765	amino acid transport
L483_RS29725	COG2943	transferase activity, transferring hexosyl groups
L483_RS29730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
L483_RS29735	COG1490	D-aminoacyl-tRNA deacylase activity
L483_RS29755	COG1228	amidohydrolase
L483_RS29765	COG2986	histidine ammonia-lyase
L483_RS29770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L483_RS29780	COG2188	Transcriptional regulator
L483_RS29785	COG0402	S-adenosylhomocysteine deaminase activity
L483_RS29805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L483_RS29810	COG0058	SHG alpha-glucan phosphorylase activity
L483_RS29820	COG1217	gtp-binding protein TYPA
L483_RS29825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L483_RS29825	COG0301	tRNA thio-modification
L483_RS29835	COG3852	Histidine kinase
L483_RS29850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L483_RS29855	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L483_RS29865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L483_RS29870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L483_RS29875	COG4942	peptidase
L483_RS29880	COG0793	Belongs to the peptidase S41A family
L483_RS29885	COG2861	carbohydrate metabolic process
L483_RS29890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L483_RS29895	COG1309	transcriptional regulator
L483_RS29900	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS29905	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L483_RS29915	COG3263	regulation of cellular component size
L483_RS29920	COG1196	nuclear chromosome segregation
L483_RS29920	COG3264	Mechanosensitive ion channel
L483_RS29925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L483_RS29930	COG3118	belongs to the thioredoxin family
L483_RS29940	COG1192	Involved in chromosome partitioning
L483_RS29945	COG0583	DNA-binding transcription factor activity
L483_RS29950	COG2814	Major facilitator Superfamily
L483_RS29960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L483_RS29965	COG0493	'glutamate synthase
L483_RS29970	COG0067	glutamate synthase
L483_RS29970	COG0070	glutamate synthase
L483_RS29970	COG0069	glutamate synthase activity
L483_RS29980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L483_RS29985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L483_RS30015	COG0281	malic enzyme
L483_RS30025	COG0254	rRNA binding
L483_RS30030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L483_RS30035	COG0018	arginyl-trna synthetase
L483_RS30050	COG0791	NLP P60 protein
L483_RS30075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L483_RS30080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L483_RS30080	COG2813	Specifically methylates the guanine in position
L483_RS30090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L483_RS30095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L483_RS30105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L483_RS30110	COG2022	thiamine diphosphate biosynthetic process
L483_RS30115	COG2104	thiamine diphosphate biosynthetic process
L483_RS30115	COG2022	thiamine diphosphate biosynthetic process
L483_RS30120	COG2363	Small membrane protein
L483_RS30125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L483_RS30135	COG2177	Part of the ABC transporter FtsEX involved in
L483_RS30140	COG2884	Cell division ATP-binding protein ftsE
L483_RS30145	COG0552	protein localization to endoplasmic reticulum
L483_RS30150	COG0612	Peptidase, M16
L483_RS30155	COG0612	Peptidase, M16
L483_RS30160	COG0742	ribosomal rna small subunit methyltransferase
L483_RS30165	COG0612	Peptidase, M16
L483_RS30195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L483_RS30200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L483_RS30205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L483_RS30215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L483_RS30225	COG0129	dihydroxy-acid dehydratase activity
L483_RS30235	COG1823	symporter activity
L483_RS30250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L483_RS30255	COG1840	ABC-type Fe3 transport system, periplasmic component
L483_RS30260	COG1178	ABC-type Fe3 transport system permease component
L483_RS30265	COG3842	ATPase activity
L483_RS30280	COG0789	Transcriptional regulator
L483_RS30285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L483_RS30290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L483_RS30295	COG0730	response to heat
L483_RS30300	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
L483_RS30305	COG0494	nUDIX hydrolase
L483_RS30320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L483_RS30325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L483_RS30330	COG3204	pilus organization
L483_RS30335	COG3204	pilus organization
L483_RS30340	COG0179	Fumarylacetoacetate (FAA) hydrolase
L483_RS30345	COG0277	FAD linked oxidase domain protein
L483_RS30350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L483_RS30360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS30365	COG1683	Conserved Protein
L483_RS30400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L483_RS30405	COG1126	abc transporter atp-binding protein
L483_RS30410	COG0765	amino acid transport
L483_RS30415	COG0765	amino acid transport
L483_RS30425	COG3829	transcription factor binding
L483_RS30450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L483_RS30455	COG4208	sulfate ABC transporter
L483_RS30465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L483_RS30475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L483_RS30495	COG1177	transmembrane transport
L483_RS30500	COG1176	ABC-type spermidine putrescine transport system, permease component I
L483_RS30505	COG3842	ATPase activity
L483_RS30525	COG0174	glutamine synthetase
L483_RS30530	COG0174	glutamine synthetase
L483_RS30535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L483_RS30535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L483_RS30540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L483_RS30550	COG1522	sequence-specific DNA binding
L483_RS30560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L483_RS30570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L483_RS30570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L483_RS30575	COG0509	glycine decarboxylation via glycine cleavage system
L483_RS30580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L483_RS30585	COG1178	ABC-type Fe3 transport system permease component
L483_RS30595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L483_RS30605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L483_RS30610	COG0006	proline dipeptidase activity
L483_RS30615	COG3079	Belongs to the UPF0149 family
L483_RS30630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L483_RS30640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L483_RS30650	COG0842	Transport permease protein
L483_RS30675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L483_RS30695	COG0248	Ppx GppA phosphatase
L483_RS30700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L483_RS30715	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L483_RS30720	COG1671	Belongs to the UPF0178 family
L483_RS30725	COG3072	Adenylate cyclase
L483_RS30730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L483_RS30740	COG1965	Belongs to the frataxin family
L483_RS30750	COG0019	diaminopimelate decarboxylase activity
L483_RS30755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L483_RS30765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L483_RS30770	COG0546	phosphoglycolate phosphatase activity
L483_RS30780	COG0004	ammonium transporteR
L483_RS30785	COG0347	Belongs to the P(II) protein family
L483_RS30835	COG0606	chelatase, subunit chli
L483_RS30850	COG0583	DNA-binding transcription factor activity
L483_RS30865	COG1335	isochorismatase
L483_RS30875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS30880	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS30885	COG0583	DNA-binding transcription factor activity
L483_RS30890	COG5383	Protein conserved in bacteria
L483_RS30895	COG0583	DNA-binding transcription factor activity
L483_RS30900	COG0534	Mate efflux family protein
L483_RS30915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L483_RS30920	COG0427	acetyl-CoA hydrolase
L483_RS30940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS30955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L483_RS30965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L483_RS30970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L483_RS30980	COG1012	belongs to the aldehyde dehydrogenase family
L483_RS30990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L483_RS30995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L483_RS31000	COG0747	negative chemotaxis
L483_RS31005	COG2003	Belongs to the UPF0758 family
L483_RS31010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L483_RS31015	COG0756	dUTP diphosphatase activity
L483_RS31020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L483_RS31025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L483_RS31030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L483_RS31035	COG0708	Exodeoxyribonuclease III
L483_RS31040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L483_RS31045	COG1561	YicC-like family, N-terminal region
L483_RS31050	COG0194	GDP metabolic process
L483_RS31060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L483_RS31065	COG0174	glutamine synthetase
L483_RS31075	COG1758	RNA polymerase activity
L483_RS31080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L483_RS31105	COG0848	biopolymer transport protein
L483_RS31115	COG0583	DNA-binding transcription factor activity
L483_RS31120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L483_RS31150	COG3161	chorismate lyase activity
L483_RS31155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L483_RS31175	COG1253	flavin adenine dinucleotide binding
L483_RS31180	COG0739	heme binding
L483_RS31190	COG0704	Plays a role in the regulation of phosphate uptake
L483_RS31195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L483_RS31200	COG0581	inorganic phosphate transmembrane transporter activity
L483_RS31215	COG0477	Major facilitator Superfamily
L483_RS31220	COG1607	acyl-coa hydrolase
L483_RS31250	COG0583	DNA-binding transcription factor activity
L483_RS31255	COG1027	Aspartate ammonia-lyase
L483_RS31295	COG5016	pyruvate
L483_RS31295	COG0511	ligase activity, forming carbon-carbon bonds
L483_RS31300	COG0439	Biotin carboxylase
L483_RS31305	COG0583	DNA-binding transcription factor activity
L483_RS31315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L483_RS31325	COG0210	DNA helicase
L483_RS31340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L483_RS31340	COG4651	solute:proton antiporter activity
L483_RS31345	COG1607	acyl-coa hydrolase
L483_RS31350	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L483_RS31360	COG0523	cobalamin synthesis protein
L483_RS31380	COG1469	GTP cyclohydrolase I activity
L483_RS31390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L483_RS31395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L483_RS31400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L483_RS31420	COG2814	Major facilitator Superfamily
L483_RS31430	COG1230	cation diffusion facilitator family transporter
L483_RS31455	COG1238	metal cluster binding
L483_RS31470	COG0659	secondary active sulfate transmembrane transporter activity
L483_RS31475	COG0589	response to stress
L483_RS31485	COG2433	Pfam Transposase IS66
L483_RS31590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L483_RS31595	COG1349	DNA-binding transcription factor activity
L483_RS31600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L483_RS31605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L483_RS31610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L483_RS31615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L483_RS31620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L483_RS31625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L483_RS31630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L483_RS31640	COG0356	it plays a direct role in the translocation of protons across the membrane
L483_RS31645	COG3312	ion transport
L483_RS31650	COG1475	DNA binding
L483_RS31655	COG1192	Involved in chromosome partitioning
L483_RS31660	COG0357	Ribosomal RNA small subunit methyltransferase G
L483_RS31665	COG0445	tRNA wobble uridine modification
L483_RS31670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L483_RS31675	COG0706	membrane insertase activity
L483_RS31680	COG0594	ribonuclease P activity
L483_RS31685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L483_RS31690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L483_RS31695	COG0592	DNA-directed DNA polymerase activity
L483_RS31700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L483_RS31705	COG0187	DNA topoisomerase II activity
L483_RS31745	COG0477	Major facilitator Superfamily
L483_RS31755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L483_RS31760	COG0751	glycine-tRNA ligase activity
L483_RS31765	COG0752	glycyl-tRNA synthetase alpha subunit
L483_RS31770	COG2818	Glycosylase
L483_RS31790	COG0569	domain protein
L483_RS31795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L483_RS31800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L483_RS31805	COG0242	peptide deformylase activity
L483_RS31810	COG0758	DNA mediated transformation
L483_RS31815	COG0009	L-threonylcarbamoyladenylate synthase
L483_RS31895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L483_RS31900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity