locus-tag	class	description
PP4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PP4_RS00010	COG0592	DNA-directed DNA polymerase activity
PP4_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PP4_RS00020	COG0187	DNA topoisomerase II activity
PP4_RS00080	COG2194	sulfuric ester hydrolase activity
PP4_RS00130	COG0463	Glycosyl transferase, family 2
PP4_RS00240	COG0477	Major facilitator Superfamily
PP4_RS00250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PP4_RS00255	COG0751	glycine-tRNA ligase activity
PP4_RS00260	COG0752	glycyl-tRNA synthetase alpha subunit
PP4_RS00265	COG2818	Glycosylase
PP4_RS00280	COG0569	domain protein
PP4_RS00285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PP4_RS00290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PP4_RS00295	COG0242	peptide deformylase activity
PP4_RS00300	COG0758	DNA mediated transformation
PP4_RS00305	COG0009	L-threonylcarbamoyladenylate synthase
PP4_RS00325	COG0408	coproporphyrinogen oxidase activity
PP4_RS00330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PP4_RS00335	COG0659	secondary active sulfate transmembrane transporter activity
PP4_RS00345	COG3119	arylsulfatase activity
PP4_RS00365	COG0159	tryptophan synthase activity
PP4_RS00370	COG0133	tryptophan synthase activity
PP4_RS00385	COG3360	Dodecin
PP4_RS00395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS00400	COG1764	response to oxidative stress
PP4_RS00430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PP4_RS00435	COG0339	signal peptide processing
PP4_RS00440	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PP4_RS00455	COG0659	secondary active sulfate transmembrane transporter activity
PP4_RS00465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PP4_RS00470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PP4_RS00475	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PP4_RS00500	COG1612	heme a metabolic process
PP4_RS00505	COG0109	protoheme IX farnesyltransferase activity
PP4_RS00520	COG2011	ABC-type metal ion transport system permease component
PP4_RS00525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PP4_RS00540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PP4_RS00545	COG1121	(ABC) transporter
PP4_RS00550	COG0735	belongs to the Fur family
PP4_RS00555	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PP4_RS00575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PP4_RS00580	COG3245	cytochrome
PP4_RS00590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PP4_RS00605	COG3023	N-Acetylmuramoyl-L-alanine amidase
PP4_RS00610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PP4_RS00615	COG5002	protein histidine kinase activity
PP4_RS00620	COG2204	response regulator
PP4_RS00645	COG1301	dicarboxylic acid transport
PP4_RS00650	COG0700	Nucleoside recognition
PP4_RS00665	COG1127	ABC transporter
PP4_RS00670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PP4_RS00685	COG1283	sodium-dependent phosphate transmembrane transporter activity
PP4_RS00690	COG0861	Integral membrane protein TerC family
PP4_RS00695	COG2851	Citrate transporter
PP4_RS00730	COG0427	acetyl-CoA hydrolase
PP4_RS00750	COG0583	DNA-binding transcription factor activity
PP4_RS00755	COG1960	acyl-CoA dehydrogenase activity
PP4_RS00815	COG3712	iron ion homeostasis
PP4_RS00825	COG1802	Transcriptional regulator
PP4_RS00835	COG3300	MHYT domain
PP4_RS00835	COG5001	Diguanylate cyclase
PP4_RS00840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS00860	COG2175	clavaminate synthase activity
PP4_RS00875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS00895	COG1289	transmembrane transporter activity
PP4_RS00905	COG1566	PFAM secretion protein HlyD family protein
PP4_RS00920	COG0672	)-iron permease
PP4_RS00935	COG0625	glutathione transferase activity
PP4_RS00940	COG0165	Argininosuccinate lyase
PP4_RS00950	COG0181	hydroxymethylbilane synthase activity
PP4_RS00970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PP4_RS00995	COG0488	(ABC) transporter
PP4_RS01005	COG1280	lysine exporter protein (LysE YggA)
PP4_RS01035	COG0516	GMP reductase activity
PP4_RS01035	COG0517	IMP dehydrogenase activity
PP4_RS01060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PP4_RS01070	COG1136	(ABC) transporter
PP4_RS01110	COG2188	Transcriptional regulator
PP4_RS01115	COG1053	succinate dehydrogenase
PP4_RS01130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS01155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS01160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS01175	COG4771	TonB-dependent receptor
PP4_RS01185	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS01190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PP4_RS01200	COG2199	diguanylate cyclase activity
PP4_RS01220	COG2011	ABC-type metal ion transport system permease component
PP4_RS01225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PP4_RS01230	COG1464	Belongs to the NlpA lipoprotein family
PP4_RS01250	COG1126	abc transporter atp-binding protein
PP4_RS01255	COG0765	amino acid transport
PP4_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS01265	COG1045	serine acetyltransferase
PP4_RS01270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PP4_RS01275	COG2175	clavaminate synthase activity
PP4_RS01280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS01285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PP4_RS01290	COG4521	taurine ABC transporter
PP4_RS01300	COG0450	alkyl hydroperoxide reductase
PP4_RS01305	COG0431	NADPH-dependent FMN reductase
PP4_RS01310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS01315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS01320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS01325	COG1116	anion transmembrane transporter activity
PP4_RS01340	COG2918	glutathione biosynthetic process
PP4_RS01350	COG2183	response to ionizing radiation
PP4_RS01365	COG0189	ligase activity
PP4_RS01370	COG0189	ligase activity
PP4_RS01370	COG4067	protein conserved in archaea
PP4_RS01375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PP4_RS01385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PP4_RS01390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PP4_RS01415	COG0243	molybdopterin cofactor binding
PP4_RS01420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PP4_RS01425	COG1652	LysM domain
PP4_RS01430	COG1011	Hydrolase
PP4_RS01435	COG0494	nUDIX hydrolase
PP4_RS01465	COG2957	Belongs to the agmatine deiminase family
PP4_RS01485	COG0069	glutamate synthase activity
PP4_RS01525	COG0582	viral genome integration into host DNA
PP4_RS01555	COG4215	(ABC) transporter
PP4_RS01590	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PP4_RS01595	COG1194	a g-specific adenine glycosylase
PP4_RS01605	COG2223	nitrite transmembrane transporter activity
PP4_RS01610	COG0131	Imidazoleglycerol-phosphate dehydratase
PP4_RS01615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PP4_RS01625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PP4_RS01630	COG0107	imidazoleglycerol-phosphate synthase activity
PP4_RS01635	COG4175	Glycine betaine
PP4_RS01640	COG4176	ABC-type proline glycine betaine transport system permease component
PP4_RS01650	COG1760	l-serine dehydratase
PP4_RS01680	COG1250	3-hydroxyacyl-CoA dehydrogenase
PP4_RS01685	COG3246	L-lysine catabolic process to acetate
PP4_RS01715	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS01715	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS01720	COG2181	nitrate reductase activity
PP4_RS01720	COG0247	lactate metabolic process
PP4_RS01725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PP4_RS01740	COG4638	Rieske (2fe-2S)
PP4_RS01745	COG1017	nitric oxide dioxygenase activity
PP4_RS01745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PP4_RS01765	COG0840	transmembrane signaling receptor activity
PP4_RS01775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PP4_RS01805	COG1063	alcohol dehydrogenase
PP4_RS01820	COG0531	amino acid
PP4_RS01825	COG0204	Acyl-transferase
PP4_RS01840	COG0745	RESPONSE REGULATOR receiver
PP4_RS01845	COG2205	protein histidine kinase activity
PP4_RS01850	COG4452	Inner membrane protein CreD
PP4_RS01860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PP4_RS01880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PP4_RS01895	COG0438	transferase activity, transferring glycosyl groups
PP4_RS01935	COG4774	siderophore transport
PP4_RS01940	COG3712	iron ion homeostasis
PP4_RS01945	COG1595	DNA-templated transcription, initiation
PP4_RS01950	COG2176	DNA-directed DNA polymerase activity
PP4_RS01965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PP4_RS01985	COG2005	Transcriptional regulator
PP4_RS01985	COG3585	molybdate ion transport
PP4_RS01995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PP4_RS02000	COG0156	8-amino-7-oxononanoate synthase activity
PP4_RS02025	COG1960	acyl-CoA dehydrogenase activity
PP4_RS02030	COG3706	GGDEF domain
PP4_RS02035	COG1960	acyl-CoA dehydrogenase activity
PP4_RS02040	COG0583	DNA-binding transcription factor activity
PP4_RS02045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PP4_RS02060	COG0535	radical SAM domain protein
PP4_RS02070	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PP4_RS02075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PP4_RS02080	COG1025	Belongs to the peptidase M16 family
PP4_RS02085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PP4_RS02095	COG2944	sequence-specific DNA binding
PP4_RS02135	COG0358	DNA primase activity
PP4_RS02140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PP4_RS02145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PP4_RS02150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PP4_RS02155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PP4_RS02165	COG0617	tRNA 3'-terminal CCA addition
PP4_RS02170	COG2719	SpoVR family
PP4_RS02175	COG2718	Belongs to the UPF0229 family
PP4_RS02180	COG2766	serine protein kinase
PP4_RS02185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PP4_RS02190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PP4_RS02195	COG2967	ApaG domain
PP4_RS02200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PP4_RS02205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PP4_RS02210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PP4_RS02215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PP4_RS02220	COG3178	'Phosphotransferase
PP4_RS02225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PP4_RS02230	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PP4_RS02240	COG4585	Histidine kinase
PP4_RS02245	COG2197	response regulator
PP4_RS02250	COG3842	ATPase activity
PP4_RS02260	COG1176	ABC-type spermidine putrescine transport system, permease component I
PP4_RS02270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PP4_RS02275	COG0546	phosphoglycolate phosphatase activity
PP4_RS02280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PP4_RS02285	COG3240	lipase activity
PP4_RS02285	COG4625	pathogenesis
PP4_RS02290	COG0512	Glutamine amidotransferase of anthranilate synthase
PP4_RS02295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PP4_RS02300	COG0134	indole-3-glycerol-phosphate synthase activity
PP4_RS02315	COG1765	OsmC-like protein
PP4_RS02325	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PP4_RS02330	COG0537	adenosine 5'-monophosphoramidase activity
PP4_RS02335	COG0300	oxidoreductase activity
PP4_RS02340	COG2070	2-Nitropropane dioxygenase
PP4_RS02345	COG1981	membrane
PP4_RS02350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PP4_RS02355	COG0316	Belongs to the HesB IscA family
PP4_RS02360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PP4_RS02365	COG0739	heme binding
PP4_RS02370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PP4_RS02400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PP4_RS02400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PP4_RS02405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PP4_RS02430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PP4_RS02450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PP4_RS02455	COG0081	regulation of translation
PP4_RS02460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PP4_RS02465	COG0222	ribosome binding
PP4_RS02470	COG0085	RNA polymerase activity
PP4_RS02475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PP4_RS02480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PP4_RS02485	COG0049	tRNA binding
PP4_RS02490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PP4_RS02495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PP4_RS02500	COG0051	transcription antitermination factor activity, RNA binding
PP4_RS02505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PP4_RS02510	COG0088	Forms part of the polypeptide exit tunnel
PP4_RS02515	COG0089	rRNA binding
PP4_RS02520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PP4_RS02525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PP4_RS02530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PP4_RS02535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PP4_RS02540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PP4_RS02545	COG0255	Belongs to the universal ribosomal protein uL29 family
PP4_RS02550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PP4_RS02555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PP4_RS02560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PP4_RS02565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PP4_RS02570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PP4_RS02575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PP4_RS02580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PP4_RS02585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PP4_RS02590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PP4_RS02595	COG1841	ribosomal large subunit assembly
PP4_RS02600	COG0200	Binds to the 23S rRNA
PP4_RS02610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PP4_RS02615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PP4_RS02620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PP4_RS02625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PP4_RS02630	COG0202	RNA polymerase activity
PP4_RS02635	COG0203	ribosomal protein L17
PP4_RS02640	COG0753	catalase activity
PP4_RS02645	COG2193	ferroxidase activity
PP4_RS02650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PP4_RS02655	COG2814	Major facilitator Superfamily
PP4_RS02660	COG0629	single-stranded DNA binding
PP4_RS02665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS02675	COG0730	response to heat
PP4_RS02680	COG4221	oxidoreductase activity
PP4_RS02685	COG0243	molybdopterin cofactor binding
PP4_RS02685	COG3383	formate dehydrogenase (NAD+) activity
PP4_RS02690	COG3383	formate dehydrogenase (NAD+) activity
PP4_RS02690	COG0243	molybdopterin cofactor binding
PP4_RS02695	COG0437	4 iron, 4 sulfur cluster binding
PP4_RS02700	COG2864	formate dehydrogenase
PP4_RS02705	COG3058	Necessary for formate dehydrogenase activity
PP4_RS02710	COG1921	L-seryl-tRNASec selenium transferase activity
PP4_RS02715	COG3276	selenocysteine insertion sequence binding
PP4_RS02725	COG0252	asparaginase activity
PP4_RS02730	COG1115	amino acid carrier protein
PP4_RS02770	COG2814	Major facilitator Superfamily
PP4_RS02775	COG3047	cAMP biosynthetic process
PP4_RS02810	COG3118	belongs to the thioredoxin family
PP4_RS02815	COG2264	protein methyltransferase activity
PP4_RS02825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PP4_RS02830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PP4_RS02830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PP4_RS02845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PP4_RS02850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PP4_RS02855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PP4_RS02860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PP4_RS02870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PP4_RS02880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PP4_RS02885	COG4206	TonB-dependent receptor
PP4_RS02890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PP4_RS02895	COG0142	geranyltranstransferase activity
PP4_RS02900	COG1722	exodeoxyribonuclease VII activity
PP4_RS02905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PP4_RS02910	COG1690	Belongs to the RtcB family
PP4_RS02920	COG2819	hydrolase of the alpha beta superfamily
PP4_RS02985	COG2067	long-chain fatty acid transport protein
PP4_RS03010	COG0714	Associated with various cellular activities
PP4_RS03045	COG3119	arylsulfatase activity
PP4_RS03055	COG2985	domain, Protein
PP4_RS03060	COG0668	transmembrane transport
PP4_RS03095	COG5001	Diguanylate cyclase
PP4_RS03110	COG1595	DNA-templated transcription, initiation
PP4_RS03115	COG4206	TonB-dependent receptor
PP4_RS03115	COG1629	transport
PP4_RS03125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PP4_RS03130	COG3228	Belongs to the MtfA family
PP4_RS03135	COG0586	Pfam SNARE associated Golgi protein
PP4_RS03140	COG0456	acetyltransferase
PP4_RS03145	COG4302	ethanolamine ammonia-lyase activity
PP4_RS03150	COG4303	Ethanolamine ammonia lyase large subunit
PP4_RS03155	COG0531	amino acid
PP4_RS03165	COG3284	Transcriptional regulator
PP4_RS03170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PP4_RS03185	COG0702	epimerase
PP4_RS03195	COG1063	alcohol dehydrogenase
PP4_RS03205	COG0022	dehydrogenase e1 component
PP4_RS03210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PP4_RS03215	COG3199	ATP-NAD kinase
PP4_RS03220	COG3284	Transcriptional regulator
PP4_RS03235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PP4_RS03265	COG0023	Translation Initiation Factor
PP4_RS03270	COG1166	arginine decarboxylase activity
PP4_RS03275	COG1943	Transposase
PP4_RS03280	COG0534	Mate efflux family protein
PP4_RS03285	COG2373	Large extracellular alpha-helical protein
PP4_RS03295	COG4953	penicillin-binding protein 1C
PP4_RS03325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PP4_RS03335	COG2030	dehydratase
PP4_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS03350	COG2207	Transcriptional regulator
PP4_RS03365	COG2217	Heavy metal translocating P-type atpase
PP4_RS03380	COG2814	Major facilitator Superfamily
PP4_RS03390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PP4_RS03395	COG0300	oxidoreductase activity
PP4_RS03405	COG1309	transcriptional regulator
PP4_RS03440	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PP4_RS03445	COG1074	ATP-dependent DNA helicase activity
PP4_RS03450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PP4_RS03460	COG2199	diguanylate cyclase activity
PP4_RS03465	COG3047	cAMP biosynthetic process
PP4_RS03465	COG2885	chlorophyll binding
PP4_RS03505	COG4589	Belongs to the CDS family
PP4_RS03520	COG2453	phosphatase
PP4_RS03520	COG0671	phosphoesterase, PA-phosphatase related
PP4_RS03525	COG2267	carboxylic ester hydrolase activity
PP4_RS03530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PP4_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
PP4_RS03555	COG0583	DNA-binding transcription factor activity
PP4_RS03570	COG0840	transmembrane signaling receptor activity
PP4_RS03575	COG2321	neutral zinc metallopeptidase
PP4_RS03580	COG3485	protocatechuate 3,4-dioxygenase
PP4_RS03585	COG3485	protocatechuate 3,4-dioxygenase
PP4_RS03600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PP4_RS03605	COG2252	PERMEase
PP4_RS03615	COG1271	oxidase subunit
PP4_RS03620	COG1294	oxidase, subunit
PP4_RS03630	COG2813	Specifically methylates the guanine in position
PP4_RS03635	COG2197	response regulator
PP4_RS03645	COG1970	mechanosensitive ion channel activity
PP4_RS03655	COG2233	PERMEase
PP4_RS03665	COG1966	Carbon starvation protein
PP4_RS03670	COG2879	small protein
PP4_RS03675	COG0523	cobalamin synthesis protein
PP4_RS03685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PP4_RS03705	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PP4_RS03735	COG0789	Transcriptional regulator
PP4_RS03745	COG1366	Belongs to the anti-sigma-factor antagonist family
PP4_RS03755	COG0583	DNA-binding transcription factor activity
PP4_RS03760	COG1380	Effector of murein hydrolase LrgA
PP4_RS03765	COG1346	cytolysis
PP4_RS03770	COG0596	Alpha beta hydrolase
PP4_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS03785	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PP4_RS03875	COG4964	Belongs to the GSP D family
PP4_RS03900	COG4772	TonB-dependent receptor
PP4_RS03905	COG3712	iron ion homeostasis
PP4_RS03910	COG1595	DNA-templated transcription, initiation
PP4_RS03945	COG3708	Transcriptional regulator
PP4_RS03945	COG2207	Transcriptional regulator
PP4_RS03950	COG0697	spore germination
PP4_RS03955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PP4_RS03960	COG0583	DNA-binding transcription factor activity
PP4_RS03980	COG1566	PFAM secretion protein HlyD family protein
PP4_RS04020	COG0300	oxidoreductase activity
PP4_RS04030	COG0662	Cupin 2, conserved barrel domain protein
PP4_RS04030	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PP4_RS04045	COG1696	Membrane protein involved in D-alanine export
PP4_RS04060	COG3420	alginic acid biosynthetic process
PP4_RS04070	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PP4_RS04075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS04080	COG1215	transferase activity, transferring glycosyl groups
PP4_RS04085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PP4_RS04090	COG3022	response to hydroperoxide
PP4_RS04100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PP4_RS04105	COG0315	cyclic pyranopterin monophosphate synthase activity
PP4_RS04110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PP4_RS04120	COG0513	Belongs to the DEAD box helicase family
PP4_RS04125	COG0400	carboxylic ester hydrolase activity
PP4_RS04130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS04135	COG4597	amino acid ABC transporter
PP4_RS04140	COG0765	amino acid transport
PP4_RS04145	COG1126	abc transporter atp-binding protein
PP4_RS04150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PP4_RS04160	COG0175	sulfate reduction
PP4_RS04170	COG1522	sequence-specific DNA binding
PP4_RS04190	COG0180	Tryptophanyl-tRNA synthetase
PP4_RS04195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PP4_RS04205	COG0667	Aldo Keto reductase
PP4_RS04210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PP4_RS04215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PP4_RS04220	COG0723	plastoquinol--plastocyanin reductase activity
PP4_RS04225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PP4_RS04230	COG2857	Cytochrome c1
PP4_RS04235	COG0625	glutathione transferase activity
PP4_RS04240	COG2969	positive regulation of protein catabolic process
PP4_RS04250	COG2823	Periplasmic or secreted lipoprotein
PP4_RS04255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PP4_RS04260	COG0792	nuclease activity
PP4_RS04265	COG3107	peptidoglycan biosynthetic process
PP4_RS04275	COG2001	Belongs to the MraZ family
PP4_RS04280	COG0275	rRNA processing
PP4_RS04295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PP4_RS04300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PP4_RS04305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PP4_RS04310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PP4_RS04315	COG0772	Belongs to the SEDS family
PP4_RS04320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PP4_RS04325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PP4_RS04330	COG1181	Belongs to the D-alanine--D-alanine ligase family
PP4_RS04345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PP4_RS04350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PP4_RS04360	COG0653	protein targeting
PP4_RS04365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PP4_RS04375	COG0352	thiamine-phosphate diphosphorylase activity
PP4_RS04380	COG2096	Adenosyltransferase
PP4_RS04395	COG1666	GTP binding
PP4_RS04400	COG0668	transmembrane transport
PP4_RS04430	COG3030	protein affecting phage T7 exclusion by the F plasmid
PP4_RS04435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PP4_RS04440	COG0459	protein refolding
PP4_RS04455	COG0642	Histidine kinase
PP4_RS04465	COG3642	lipopolysaccharide core region biosynthetic process
PP4_RS04475	COG2814	Major facilitator Superfamily
PP4_RS04485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PP4_RS04490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS04525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PP4_RS04535	COG0583	DNA-binding transcription factor activity
PP4_RS04540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PP4_RS04550	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS04595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PP4_RS04600	COG0693	protein deglycase activity
PP4_RS04615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PP4_RS04615	COG3153	acetyltransferase
PP4_RS04630	COG0469	pyruvate kinase activity
PP4_RS04645	COG2925	Exonuclease
PP4_RS04655	COG0788	formyltetrahydrofolate deformylase activity
PP4_RS04670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PP4_RS04670	COG0438	transferase activity, transferring glycosyl groups
PP4_RS04675	COG0840	transmembrane signaling receptor activity
PP4_RS04680	COG0433	COG0433 Predicted ATPase
PP4_RS04685	COG0306	phosphate transporter
PP4_RS04695	COG1414	Transcriptional regulator
PP4_RS04700	COG2814	Major facilitator Superfamily
PP4_RS04705	COG0183	Belongs to the thiolase family
PP4_RS04710	COG0477	Major facilitator Superfamily
PP4_RS04715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PP4_RS04720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PP4_RS04725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PP4_RS04750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PP4_RS04755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS04760	COG1309	transcriptional regulator
PP4_RS04765	COG0477	Major facilitator Superfamily
PP4_RS04770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PP4_RS04785	COG2910	NAD(P)H-binding
PP4_RS04790	COG0583	DNA-binding transcription factor activity
PP4_RS04800	COG2207	Transcriptional regulator
PP4_RS04835	COG0477	Major facilitator Superfamily
PP4_RS04845	COG4191	Histidine kinase
PP4_RS04905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PP4_RS04910	COG3180	Ammonia monooxygenase
PP4_RS04950	COG0354	folic acid binding
PP4_RS04955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PP4_RS04985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PP4_RS04990	COG0481	GTPase activity
PP4_RS04995	COG0681	Belongs to the peptidase S26 family
PP4_RS05000	COG0571	ribonuclease III activity
PP4_RS05005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PP4_RS05010	COG1381	Involved in DNA repair and RecF pathway recombination
PP4_RS05015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PP4_RS05035	COG0500	methyltransferase
PP4_RS05040	COG2226	methyltransferase
PP4_RS05050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PP4_RS05065	COG4206	TonB-dependent receptor
PP4_RS05070	COG4628	conserved protein (DUF2132)
PP4_RS05080	COG2375	cellular response to nickel ion
PP4_RS05085	COG1695	Transcriptional regulator
PP4_RS05095	COG1113	amino acid transport
PP4_RS05100	COG0069	glutamate synthase activity
PP4_RS05105	COG1201	RNA secondary structure unwinding
PP4_RS05110	COG0494	nUDIX hydrolase
PP4_RS05115	COG0583	DNA-binding transcription factor activity
PP4_RS05120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PP4_RS05140	COG1126	abc transporter atp-binding protein
PP4_RS05145	COG0765	amino acid transport
PP4_RS05150	COG0765	amino acid transport
PP4_RS05175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PP4_RS05185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PP4_RS05190	COG3842	ATPase activity
PP4_RS05195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PP4_RS05200	COG0243	molybdopterin cofactor binding
PP4_RS05205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PP4_RS05225	COG0450	alkyl hydroperoxide reductase
PP4_RS05230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PP4_RS05235	COG0418	dihydroorotase activity
PP4_RS05245	COG0137	argininosuccinate synthase activity
PP4_RS05255	COG2197	response regulator
PP4_RS05265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PP4_RS05275	COG4659	FMN binding
PP4_RS05290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PP4_RS05290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PP4_RS05295	COG0489	protein tyrosine kinase activity
PP4_RS05305	COG1278	Cold shock
PP4_RS05310	COG0717	Belongs to the dCTP deaminase family
PP4_RS05325	COG1201	RNA secondary structure unwinding
PP4_RS05335	COG1793	dna ligase
PP4_RS05340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PP4_RS05340	COG1793	dna ligase
PP4_RS05345	COG2366	antibiotic biosynthetic process
PP4_RS05350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS05355	COG1045	serine acetyltransferase
PP4_RS05365	COG2814	Major facilitator Superfamily
PP4_RS05375	COG0653	protein targeting
PP4_RS05385	COG3012	SEC-C Motif Domain Protein
PP4_RS05420	COG1199	ATP-dependent helicase activity
PP4_RS05435	COG2885	chlorophyll binding
PP4_RS05440	COG0259	pyridoxamine-phosphate oxidase activity
PP4_RS05455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PP4_RS05460	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PP4_RS05510	COG2084	Dehydrogenase
PP4_RS05520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PP4_RS05540	COG1289	transmembrane transporter activity
PP4_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS05560	COG0583	DNA-binding transcription factor activity
PP4_RS05570	COG5001	Diguanylate cyclase
PP4_RS05570	COG3300	MHYT domain
PP4_RS05575	COG3706	GGDEF domain
PP4_RS05585	COG2116	formate transmembrane transporter activity
PP4_RS05615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PP4_RS05625	COG0252	asparaginase activity
PP4_RS05630	COG3318	Belongs to the UPF0149 family
PP4_RS05630	COG3012	SEC-C Motif Domain Protein
PP4_RS05635	COG3318	Belongs to the UPF0149 family
PP4_RS05635	COG3012	SEC-C Motif Domain Protein
PP4_RS05640	COG0625	glutathione transferase activity
PP4_RS05645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PP4_RS05645	COG1017	nitric oxide dioxygenase activity
PP4_RS05650	COG0583	DNA-binding transcription factor activity
PP4_RS05655	COG2271	Major facilitator Superfamily
PP4_RS05680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PP4_RS05690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PP4_RS05700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PP4_RS05705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PP4_RS05705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PP4_RS05710	COG0745	RESPONSE REGULATOR receiver
PP4_RS05715	COG2205	protein histidine kinase activity
PP4_RS05745	COG1301	dicarboxylic acid transport
PP4_RS05755	COG4807	Protein conserved in bacteria
PP4_RS05765	COG0519	Catalyzes the synthesis of GMP from XMP
PP4_RS05795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PP4_RS05800	COG3158	transport of potassium into the cell
PP4_RS05830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PP4_RS05840	COG0442	prolyl-tRNA aminoacylation
PP4_RS05855	COG2900	Belongs to the SlyX family
PP4_RS05865	COG0783	Belongs to the Dps family
PP4_RS05880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PP4_RS05885	COG0217	transcriptional regulatory protein
PP4_RS05890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PP4_RS05895	COG0632	four-way junction helicase activity
PP4_RS05900	COG2255	four-way junction helicase activity
PP4_RS05905	COG0824	Thioesterase
PP4_RS05925	COG0823	Involved in the tonB-independent uptake of proteins
PP4_RS05930	COG2885	chlorophyll binding
PP4_RS05935	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PP4_RS05940	COG0602	queuosine metabolic process
PP4_RS05945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PP4_RS05960	COG0840	transmembrane signaling receptor activity
PP4_RS05965	COG0531	amino acid
PP4_RS05975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PP4_RS05985	COG0425	Belongs to the sulfur carrier protein TusA family
PP4_RS06000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PP4_RS06010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PP4_RS06015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PP4_RS06020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PP4_RS06025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PP4_RS06075	COG1595	DNA-templated transcription, initiation
PP4_RS06080	COG0579	oxidoreductase
PP4_RS06085	COG0640	Transcriptional regulator
PP4_RS06090	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS06115	COG3938	Belongs to the proline racemase family
PP4_RS06120	COG0531	amino acid
PP4_RS06130	COG0583	DNA-binding transcription factor activity
PP4_RS06135	COG0521	Mo-molybdopterin cofactor biosynthetic process
PP4_RS06140	COG3781	membrane
PP4_RS06145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PP4_RS06150	COG0243	molybdopterin cofactor binding
PP4_RS06155	COG1522	sequence-specific DNA binding
PP4_RS06160	COG0626	cystathionine gamma-synthase activity
PP4_RS06180	COG3100	YcgL domain-containing protein
PP4_RS06195	COG2983	Belongs to the UPF0260 family
PP4_RS06220	COG2271	Major facilitator Superfamily
PP4_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS06260	COG0121	glutamine amidotransferase
PP4_RS06275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PP4_RS06280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PP4_RS06285	COG1984	allophanate hydrolase subunit 2
PP4_RS06305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PP4_RS06365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PP4_RS06385	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PP4_RS06395	COG1595	DNA-templated transcription, initiation
PP4_RS06400	COG3712	iron ion homeostasis
PP4_RS06420	COG3420	alginic acid biosynthetic process
PP4_RS06430	COG1295	ribonuclease BN
PP4_RS06435	COG0242	peptide deformylase activity
PP4_RS06460	COG3795	YCII-related domain
PP4_RS06470	COG4941	Belongs to the sigma-70 factor family
PP4_RS06475	COG2030	dehydratase
PP4_RS06480	COG2267	carboxylic ester hydrolase activity
PP4_RS06485	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS06490	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS06495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS06500	COG0174	glutamine synthetase
PP4_RS06510	COG1643	Atp-dependent helicase
PP4_RS06520	COG2188	Transcriptional regulator
PP4_RS06530	COG1132	(ABC) transporter
PP4_RS06540	COG2267	carboxylic ester hydrolase activity
PP4_RS06555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PP4_RS06565	COG0679	Auxin Efflux Carrier
PP4_RS06570	COG0668	transmembrane transport
PP4_RS06575	COG0513	Belongs to the DEAD box helicase family
PP4_RS06585	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PP4_RS06590	COG3657	addiction module killer protein
PP4_RS06600	COG0697	spore germination
PP4_RS06610	COG0583	DNA-binding transcription factor activity
PP4_RS06630	COG0840	transmembrane signaling receptor activity
PP4_RS06645	COG2832	Protein of unknown function (DUF454)
PP4_RS06655	COG0514	ATP-dependent DNA helicase (RecQ)
PP4_RS06665	COG1752	Esterase of the alpha-beta hydrolase superfamily
PP4_RS06680	COG2207	Transcriptional regulator
PP4_RS06700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PP4_RS06705	COG0778	Nitroreductase
PP4_RS06720	COG0745	RESPONSE REGULATOR receiver
PP4_RS06725	COG2350	Protein conserved in bacteria
PP4_RS06730	COG2917	probably involved in intracellular septation
PP4_RS06735	COG0613	PHP domain protein
PP4_RS06740	COG0009	L-threonylcarbamoyladenylate synthase
PP4_RS06750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PP4_RS06760	COG1113	amino acid transport
PP4_RS06770	COG0277	FAD linked oxidase domain protein
PP4_RS06770	COG0247	lactate metabolic process
PP4_RS06780	COG2154	pterin-4-alpha-carbinolamine dehydratase
PP4_RS06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PP4_RS06805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS06830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PP4_RS06845	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS06850	COG3724	N-succinylarginine dihydrolase activity
PP4_RS06860	COG2988	succinylglutamate desuccinylase activity
PP4_RS06870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PP4_RS06875	COG0527	aspartate kinase activity
PP4_RS06880	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PP4_RS06905	COG2239	Acts as a magnesium transporter
PP4_RS06945	COG3706	GGDEF domain
PP4_RS06950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PP4_RS06960	COG0022	dehydrogenase e1 component
PP4_RS06965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PP4_RS06970	COG1522	sequence-specific DNA binding
PP4_RS06980	COG0477	Major facilitator Superfamily
PP4_RS06985	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PP4_RS07005	COG0784	Response regulator, receiver
PP4_RS07005	COG0835	chemotaxis
PP4_RS07010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PP4_RS07015	COG1815	bacterial-type flagellum-dependent cell motility
PP4_RS07025	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PP4_RS07050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PP4_RS07055	COG1706	bacterial-type flagellum-dependent cell motility
PP4_RS07065	COG4786	Flagellar basal body rod
PP4_RS07065	COG1256	bacterial-type flagellum assembly
PP4_RS07075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PP4_RS07085	COG1334	flagellar protein FlaG
PP4_RS07090	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PP4_RS07130	COG0028	Belongs to the TPP enzyme family
PP4_RS07165	COG1216	Glycosyl transferase, family 2
PP4_RS07165	COG0463	Glycosyl transferase, family 2
PP4_RS07170	COG1216	Glycosyl transferase, family 2
PP4_RS07185	COG1677	Flagellar hook-basal body complex protein FliE
PP4_RS07210	COG2882	bacterial-type flagellum organization
PP4_RS07220	COG0745	RESPONSE REGULATOR receiver
PP4_RS07260	COG1987	bacterial-type flagellum assembly
PP4_RS07275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PP4_RS07300	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PP4_RS07305	COG0643	Histidine kinase
PP4_RS07305	COG2198	Histidine kinase
PP4_RS07305	COG0784	Response regulator, receiver
PP4_RS07310	COG2201	protein-glutamate methylesterase activity
PP4_RS07315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PP4_RS07320	COG1360	Flagellar Motor Protein
PP4_RS07325	COG1192	Involved in chromosome partitioning
PP4_RS07335	COG0835	chemotaxis
PP4_RS07350	COG2257	FlhB HrpN YscU SpaS Family
PP4_RS07360	COG4133	protoheme IX ABC transporter activity
PP4_RS07380	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PP4_RS07385	COG1138	Cytochrome C-type biogenesis protein
PP4_RS07410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PP4_RS07445	COG1953	Uracil, thiamine, allantoin
PP4_RS07450	COG1522	sequence-specific DNA binding
PP4_RS07460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PP4_RS07460	COG0116	Belongs to the methyltransferase superfamily
PP4_RS07465	COG0668	transmembrane transport
PP4_RS07475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PP4_RS07485	COG0469	pyruvate kinase activity
PP4_RS07495	COG2084	Dehydrogenase
PP4_RS07500	COG3622	Belongs to the hyi family
PP4_RS07505	COG3960	tartronate-semialdehyde synthase activity
PP4_RS07520	COG2354	Protein conserved in bacteria
PP4_RS07525	COG1368	sulfuric ester hydrolase activity
PP4_RS07545	COG2233	PERMEase
PP4_RS07555	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PP4_RS07575	COG2252	PERMEase
PP4_RS07585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PP4_RS07590	COG0402	S-adenosylhomocysteine deaminase activity
PP4_RS07600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PP4_RS07620	COG3115	cell septum assembly
PP4_RS07625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PP4_RS07670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PP4_RS07675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PP4_RS07680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PP4_RS07685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PP4_RS07690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PP4_RS07710	COG2217	Heavy metal translocating P-type atpase
PP4_RS07720	COG0348	domain, Protein
PP4_RS07725	COG2010	Cytochrome c
PP4_RS07740	COG3278	Belongs to the heme-copper respiratory oxidase family
PP4_RS07745	COG2010	Cytochrome c
PP4_RS07760	COG3278	Belongs to the heme-copper respiratory oxidase family
PP4_RS07770	COG3123	guanosine phosphorylase activity
PP4_RS07805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PP4_RS07825	COG2010	Cytochrome c
PP4_RS07830	COG3608	succinylglutamate desuccinylase aspartoacylase
PP4_RS07830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PP4_RS07855	COG0642	Histidine kinase
PP4_RS07875	COG0657	acetylesterase activity
PP4_RS07895	COG1538	Outer membrane efflux protein
PP4_RS07900	COG1136	(ABC) transporter
PP4_RS07900	COG0577	efflux transmembrane transporter activity
PP4_RS07905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS07950	COG3047	cAMP biosynthetic process
PP4_RS07950	COG2885	chlorophyll binding
PP4_RS07955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS07980	COG2009	succinate dehydrogenase
PP4_RS07985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PP4_RS07990	COG1053	succinate dehydrogenase
PP4_RS08010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PP4_RS08015	COG0045	succinate-CoA ligase (ADP-forming) activity
PP4_RS08050	COG0326	Molecular chaperone. Has ATPase activity
PP4_RS08060	COG1741	Belongs to the pirin family
PP4_RS08075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PP4_RS08080	COG2205	protein histidine kinase activity
PP4_RS08080	COG3437	response regulator, receiver
PP4_RS08080	COG3850	Histidine kinase
PP4_RS08080	COG4999	Histidine kinase
PP4_RS08095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PP4_RS08105	COG2062	phosphohistidine phosphatase, SixA
PP4_RS08120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PP4_RS08130	COG0628	permease
PP4_RS08140	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PP4_RS08150	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PP4_RS08155	COG2205	protein histidine kinase activity
PP4_RS08160	COG0745	RESPONSE REGULATOR receiver
PP4_RS08175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PP4_RS08180	COG1569	PIN domain
PP4_RS08185	COG3311	Transcriptional regulator
PP4_RS08195	COG4172	Belongs to the ABC transporter superfamily
PP4_RS08200	COG4239	(ABC) transporter, permease
PP4_RS08205	COG4174	ABC transporter (Permease)
PP4_RS08210	COG4166	transmembrane transport
PP4_RS08215	COG4166	transmembrane transport
PP4_RS08220	COG1388	LysM domain
PP4_RS08220	COG0741	lytic transglycosylase activity
PP4_RS08225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PP4_RS08235	COG0328	RNA-DNA hybrid ribonuclease activity
PP4_RS08255	COG0431	NADPH-dependent FMN reductase
PP4_RS08290	COG1007	ATP synthesis coupled electron transport
PP4_RS08305	COG0713	ATP synthesis coupled electron transport
PP4_RS08315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PP4_RS08320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PP4_RS08325	COG1034	ATP synthesis coupled electron transport
PP4_RS08340	COG0649	NAD binding
PP4_RS08340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PP4_RS08345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PP4_RS08350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PP4_RS08370	COG1404	Belongs to the peptidase S8 family
PP4_RS08375	COG0659	secondary active sulfate transmembrane transporter activity
PP4_RS08380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PP4_RS08395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PP4_RS08400	COG0583	DNA-binding transcription factor activity
PP4_RS08405	COG1113	amino acid transport
PP4_RS08415	COG0625	glutathione transferase activity
PP4_RS08425	COG0306	phosphate transporter
PP4_RS08430	COG3189	MarR family transcriptional regulator
PP4_RS08450	COG0322	excinuclease ABC activity
PP4_RS08470	COG2207	Transcriptional regulator
PP4_RS08510	COG4790	Type iii secretion
PP4_RS08580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PP4_RS08585	COG0235	Class ii aldolase
PP4_RS08590	COG0477	Major facilitator Superfamily
PP4_RS08595	COG0583	DNA-binding transcription factor activity
PP4_RS08615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PP4_RS08630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PP4_RS08635	COG1960	acyl-CoA dehydrogenase activity
PP4_RS08640	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS08660	COG0366	Alpha amylase catalytic
PP4_RS08665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PP4_RS08675	COG3568	Endonuclease Exonuclease Phosphatase
PP4_RS08695	COG1640	4-alpha-glucanotransferase
PP4_RS08700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PP4_RS08705	COG0297	glycogen (starch) synthase activity
PP4_RS08710	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PP4_RS08715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PP4_RS08720	COG3387	PFAM Glycoside hydrolase 15-related
PP4_RS08725	COG3093	addiction module antidote protein HigA
PP4_RS08730	COG1309	transcriptional regulator
PP4_RS08750	COG1953	Uracil, thiamine, allantoin
PP4_RS08765	COG1234	tRNA 3'-trailer cleavage
PP4_RS08785	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PP4_RS08790	COG1024	Enoyl-CoA hydratase
PP4_RS08795	COG2816	NAD+ diphosphatase activity
PP4_RS08815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS08820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PP4_RS08825	COG2153	protein acetylation
PP4_RS08830	COG2850	peptidyl-arginine hydroxylation
PP4_RS08840	COG2915	High frequency lysogenization protein hflD homolog
PP4_RS08845	COG0482	sulfurtransferase activity
PP4_RS08865	COG1278	Cold shock
PP4_RS08870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PP4_RS08875	COG0542	response to heat
PP4_RS08880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PP4_RS08885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PP4_RS08890	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PP4_RS08895	COG1674	ftsk spoiiie
PP4_RS08900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PP4_RS08905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PP4_RS08910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PP4_RS08915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PP4_RS08920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PP4_RS08920	COG1648	precorrin-2 dehydrogenase activity
PP4_RS08925	COG0435	Glutathione S-transferase
PP4_RS08930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PP4_RS08935	COG2920	part of a sulfur-relay system
PP4_RS08955	COG2233	PERMEase
PP4_RS08990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PP4_RS09000	COG0840	transmembrane signaling receptor activity
PP4_RS09005	COG0583	DNA-binding transcription factor activity
PP4_RS09020	COG1309	transcriptional regulator
PP4_RS09025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PP4_RS09025	COG2010	Cytochrome c
PP4_RS09030	COG2080	2 iron, 2 sulfur cluster binding
PP4_RS09035	COG1846	Transcriptional regulator
PP4_RS09040	COG2309	aminopeptidase activity
PP4_RS09045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PP4_RS09050	COG0596	Alpha beta hydrolase
PP4_RS09055	COG3473	Maleate cis-trans isomerase
PP4_RS09060	COG1335	isochorismatase
PP4_RS09065	COG2271	Major facilitator Superfamily
PP4_RS09095	COG2199	diguanylate cyclase activity
PP4_RS09100	COG0471	metal ion transport
PP4_RS09100	COG0490	domain, Protein
PP4_RS09130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PP4_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS09155	COG0616	signal peptide processing
PP4_RS09205	COG0629	single-stranded DNA binding
PP4_RS09260	COG1598	PFAM Uncharacterised protein family UPF0150
PP4_RS09265	COG1724	mRNA binding
PP4_RS09280	COG2135	peptidase activity
PP4_RS09290	COG1073	alpha beta
PP4_RS09310	COG0667	Aldo Keto reductase
PP4_RS09320	COG0667	Aldo Keto reductase
PP4_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS09365	COG1064	alcohol dehydrogenase
PP4_RS09375	COG2259	Doxx family
PP4_RS09390	COG0784	Response regulator, receiver
PP4_RS09390	COG4191	Histidine kinase
PP4_RS09395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PP4_RS09400	COG0745	RESPONSE REGULATOR receiver
PP4_RS09405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PP4_RS09415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PP4_RS09445	COG2863	cytochrome
PP4_RS09450	COG3258	Cytochrome c
PP4_RS09470	COG3634	alkyl hydroperoxide reductase activity
PP4_RS09480	COG3132	Protein of unknown function, DUF480
PP4_RS09485	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PP4_RS09490	COG0583	DNA-binding transcription factor activity
PP4_RS09500	COG1253	flavin adenine dinucleotide binding
PP4_RS09510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS09530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PP4_RS09545	COG4772	TonB-dependent receptor
PP4_RS09575	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS09580	COG0531	amino acid
PP4_RS09590	COG2207	Transcriptional regulator
PP4_RS09595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS09600	COG1846	Transcriptional regulator
PP4_RS09610	COG1960	acyl-CoA dehydrogenase activity
PP4_RS09615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PP4_RS09625	COG3971	2-oxopent-4-enoate hydratase activity
PP4_RS09630	COG2271	Major facilitator Superfamily
PP4_RS09640	COG3384	dioxygenase
PP4_RS09645	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS09655	COG0179	Fumarylacetoacetate (FAA) hydrolase
PP4_RS09665	COG1846	Transcriptional regulator
PP4_RS09670	COG0252	asparaginase activity
PP4_RS09675	COG1879	ABC-type sugar transport system periplasmic component
PP4_RS09680	COG1129	ABC transporter
PP4_RS09685	COG1172	Belongs to the binding-protein-dependent transport system permease family
PP4_RS09690	COG1609	Transcriptional regulator
PP4_RS09695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PP4_RS09700	COG1869	D-ribose catabolic process
PP4_RS09720	COG1278	Cold shock
PP4_RS09730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PP4_RS09735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PP4_RS09740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PP4_RS09745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PP4_RS09750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PP4_RS09755	COG0072	phenylalanine-tRNA ligase activity
PP4_RS09760	COG0776	regulation of translation
PP4_RS09780	COG1401	restriction endodeoxyribonuclease activity
PP4_RS09805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PP4_RS09830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS09835	COG0697	spore germination
PP4_RS09845	COG2066	Belongs to the glutaminase family
PP4_RS09885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PP4_RS09905	COG2873	o-acetylhomoserine
PP4_RS09935	COG1231	oxidoreductase activity
PP4_RS09940	COG4771	TonB-dependent receptor
PP4_RS09975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PP4_RS09985	COG0583	DNA-binding transcription factor activity
PP4_RS09990	COG2814	Major facilitator Superfamily
PP4_RS09995	COG0625	glutathione transferase activity
PP4_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS10020	COG5642	Protein of unknown function (DUF2384)
PP4_RS10025	COG5654	RES domain protein
PP4_RS10030	COG1104	cysteine desulfurase activity
PP4_RS10055	COG0861	Integral membrane protein TerC family
PP4_RS10065	COG3842	ATPase activity
PP4_RS10070	COG1177	transmembrane transport
PP4_RS10075	COG1176	ABC-type spermidine putrescine transport system, permease component I
PP4_RS10085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PP4_RS10100	COG0583	DNA-binding transcription factor activity
PP4_RS10105	COG4221	oxidoreductase activity
PP4_RS10120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PP4_RS10120	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS10135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PP4_RS10180	COG1121	(ABC) transporter
PP4_RS10220	COG1686	Belongs to the peptidase S11 family
PP4_RS10265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PP4_RS10300	COG0784	Response regulator, receiver
PP4_RS10300	COG2198	Histidine kinase
PP4_RS10300	COG2205	protein histidine kinase activity
PP4_RS10305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PP4_RS10315	COG2205	protein histidine kinase activity
PP4_RS10315	COG0784	Response regulator, receiver
PP4_RS10320	COG2198	Histidine kinase
PP4_RS10320	COG2205	protein histidine kinase activity
PP4_RS10320	COG0784	Response regulator, receiver
PP4_RS10320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS10330	COG1250	3-hydroxyacyl-CoA dehydrogenase
PP4_RS10335	COG0183	Belongs to the thiolase family
PP4_RS10345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PP4_RS10350	COG2807	transmembrane transport
PP4_RS10370	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PP4_RS10375	COG0247	lactate metabolic process
PP4_RS10380	COG0277	FAD linked oxidase domain protein
PP4_RS10385	COG0277	FAD linked oxidase domain protein
PP4_RS10390	COG2186	Transcriptional regulator
PP4_RS10400	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS10405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PP4_RS10410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS10415	COG2207	Transcriptional regulator
PP4_RS10415	COG0662	Cupin 2, conserved barrel domain protein
PP4_RS10425	COG2271	Major facilitator Superfamily
PP4_RS10435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS10460	COG1309	transcriptional regulator
PP4_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS10470	COG4221	oxidoreductase activity
PP4_RS10485	COG0436	Aminotransferase
PP4_RS10490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PP4_RS10500	COG0028	Belongs to the TPP enzyme family
PP4_RS10505	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS10510	COG2186	Transcriptional regulator
PP4_RS10520	COG0559	Belongs to the binding-protein-dependent transport system permease family
PP4_RS10540	COG0768	penicillin binding
PP4_RS10560	COG2814	Major facilitator Superfamily
PP4_RS10600	COG4181	ATPase activity
PP4_RS10605	COG0577	efflux transmembrane transporter activity
PP4_RS10615	COG1024	Enoyl-CoA hydratase
PP4_RS10640	COG0833	amino acid
PP4_RS10645	COG1024	Enoyl-CoA hydratase
PP4_RS10650	COG1960	acyl-CoA dehydrogenase activity
PP4_RS10665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PP4_RS10680	COG2249	NAD(P)H dehydrogenase (quinone) activity
PP4_RS10700	COG5002	protein histidine kinase activity
PP4_RS10700	COG3447	MASE1 domain protein
PP4_RS10700	COG5001	Diguanylate cyclase
PP4_RS10705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PP4_RS10725	COG0583	DNA-binding transcription factor activity
PP4_RS10730	COG1522	sequence-specific DNA binding
PP4_RS10740	COG1113	amino acid transport
PP4_RS10750	COG4948	Mandelate Racemase Muconate Lactonizing
PP4_RS10755	COG4829	muconolactone delta-isomerase
PP4_RS10760	COG3485	protocatechuate 3,4-dioxygenase
PP4_RS10770	COG5001	Diguanylate cyclase
PP4_RS10775	COG0656	L-ascorbic acid biosynthetic process
PP4_RS10790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PP4_RS10800	COG0477	Major facilitator Superfamily
PP4_RS10810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PP4_RS10820	COG0583	DNA-binding transcription factor activity
PP4_RS10825	COG5001	Diguanylate cyclase
PP4_RS10825	COG5002	protein histidine kinase activity
PP4_RS10825	COG3447	MASE1 domain protein
PP4_RS10830	COG1611	Belongs to the LOG family
PP4_RS10835	COG2855	membrane
PP4_RS10865	COG3920	Histidine kinase
PP4_RS10870	COG2814	Major facilitator Superfamily
PP4_RS10885	COG3485	protocatechuate 3,4-dioxygenase
PP4_RS10890	COG0583	DNA-binding transcription factor activity
PP4_RS10905	COG0583	DNA-binding transcription factor activity
PP4_RS10920	COG0673	inositol 2-dehydrogenase activity
PP4_RS10925	COG0673	inositol 2-dehydrogenase activity
PP4_RS10940	COG4214	carbohydrate transport
PP4_RS10950	COG1609	Transcriptional regulator
PP4_RS10955	COG4993	Dehydrogenase
PP4_RS10965	COG0765	amino acid transport
PP4_RS10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS10990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PP4_RS10995	COG2218	PFAM glutamate synthase alpha subunit domain protein
PP4_RS11000	COG0069	glutamate synthase activity
PP4_RS11005	COG0004	ammonium transporteR
PP4_RS11010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PP4_RS11025	COG0784	Response regulator, receiver
PP4_RS11025	COG4191	Histidine kinase
PP4_RS11030	COG2816	NAD+ diphosphatase activity
PP4_RS11035	COG2186	Transcriptional regulator
PP4_RS11040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PP4_RS11050	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS11055	COG2267	carboxylic ester hydrolase activity
PP4_RS11065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS11070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PP4_RS11075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PP4_RS11105	COG2207	Transcriptional regulator
PP4_RS11120	COG1116	anion transmembrane transporter activity
PP4_RS11125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS11130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS11140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PP4_RS11155	COG4991	sh3 domain protein
PP4_RS11170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PP4_RS11215	COG1944	ATP diphosphatase activity
PP4_RS11265	COG2391	methyltransferase activity
PP4_RS11275	COG0583	DNA-binding transcription factor activity
PP4_RS11290	COG2186	Transcriptional regulator
PP4_RS11295	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS11300	COG2721	sulfolactate sulfo-lyase activity
PP4_RS11305	COG2271	Major facilitator Superfamily
PP4_RS11310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PP4_RS11315	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PP4_RS11320	COG1126	abc transporter atp-binding protein
PP4_RS11325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS11335	COG4215	(ABC) transporter
PP4_RS11365	COG0814	amino acid
PP4_RS11415	COG1595	DNA-templated transcription, initiation
PP4_RS11420	COG3712	iron ion homeostasis
PP4_RS11425	COG4774	siderophore transport
PP4_RS11440	COG2271	Major facilitator Superfamily
PP4_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS11460	COG2072	flavoprotein involved in K transport
PP4_RS11490	COG0583	DNA-binding transcription factor activity
PP4_RS11495	COG2814	Major facilitator Superfamily
PP4_RS11500	COG1280	lysine exporter protein (LysE YggA)
PP4_RS11525	COG0583	DNA-binding transcription factor activity
PP4_RS11530	COG4176	ABC-type proline glycine betaine transport system permease component
PP4_RS11540	COG0840	transmembrane signaling receptor activity
PP4_RS11545	COG2056	Na+-H+ antiporter family
PP4_RS11555	COG1960	acyl-CoA dehydrogenase activity
PP4_RS11560	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS11570	COG4566	intracellular signal transduction
PP4_RS11575	COG1846	Transcriptional regulator
PP4_RS11580	COG1566	PFAM secretion protein HlyD family protein
PP4_RS11585	COG2814	Major facilitator Superfamily
PP4_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS11595	COG4191	Histidine kinase
PP4_RS11595	COG0784	Response regulator, receiver
PP4_RS11600	COG0784	Response regulator, receiver
PP4_RS11600	COG4191	Histidine kinase
PP4_RS11605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS11610	COG0348	domain, Protein
PP4_RS11620	COG1285	pathogenesis
PP4_RS11630	COG0789	Transcriptional regulator
PP4_RS11635	COG2207	Transcriptional regulator
PP4_RS11650	COG0405	Gamma-glutamyltransferase
PP4_RS11655	COG0583	DNA-binding transcription factor activity
PP4_RS11665	COG2423	ornithine cyclodeaminase activity
PP4_RS11670	COG1522	sequence-specific DNA binding
PP4_RS11675	COG1113	amino acid transport
PP4_RS11695	COG3209	COG3209 Rhs family protein
PP4_RS11700	COG3257	ureidoglycine aminohydrolase activity
PP4_RS11710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS11720	COG0697	spore germination
PP4_RS11725	COG1309	transcriptional regulator
PP4_RS11770	COG3064	Membrane
PP4_RS11790	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
PP4_RS11795	COG0583	DNA-binding transcription factor activity
PP4_RS11805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PP4_RS11810	COG0488	(ABC) transporter
PP4_RS11850	COG2204	response regulator
PP4_RS11855	COG0826	peptidase U32
PP4_RS11940	COG2384	SAM-dependent methyltransferase
PP4_RS11955	COG1960	acyl-CoA dehydrogenase activity
PP4_RS12045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PP4_RS12075	COG2165	general secretion pathway protein
PP4_RS12080	COG2165	general secretion pathway protein
PP4_RS12110	COG3284	Transcriptional regulator
PP4_RS12115	COG1132	(ABC) transporter
PP4_RS12160	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS12165	COG0746	molybdenum cofactor guanylyltransferase activity
PP4_RS12175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS12180	COG0745	RESPONSE REGULATOR receiver
PP4_RS12185	COG2205	protein histidine kinase activity
PP4_RS12190	COG3706	GGDEF domain
PP4_RS12205	COG1215	transferase activity, transferring glycosyl groups
PP4_RS12215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PP4_RS12230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PP4_RS12240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PP4_RS12240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PP4_RS12250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PP4_RS12275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PP4_RS12280	COG4574	serine-type endopeptidase inhibitor activity
PP4_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS12290	COG4239	(ABC) transporter, permease
PP4_RS12295	COG4174	ABC transporter (Permease)
PP4_RS12305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PP4_RS12310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PP4_RS12315	COG1881	PFAM PEBP family protein
PP4_RS12350	COG3712	iron ion homeostasis
PP4_RS12355	COG1595	DNA-templated transcription, initiation
PP4_RS12445	COG1397	ADP-ribosylglycohydrolase
PP4_RS12480	COG2369	cell adhesion
PP4_RS12505	COG3209	COG3209 Rhs family protein
PP4_RS12520	COG3209	COG3209 Rhs family protein
PP4_RS12540	COG1473	amidohydrolase
PP4_RS12550	COG0154	amidase activity
PP4_RS12555	COG1414	Transcriptional regulator
PP4_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS12570	COG1053	succinate dehydrogenase
PP4_RS12590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PP4_RS12595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PP4_RS12610	COG0587	DNA-directed DNA polymerase activity
PP4_RS12615	COG0656	L-ascorbic acid biosynthetic process
PP4_RS12625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PP4_RS12635	COG2031	fatty acid transporter
PP4_RS12640	COG1396	sequence-specific DNA binding
PP4_RS12665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PP4_RS12705	COG1215	transferase activity, transferring glycosyl groups
PP4_RS12710	COG2990	Protein conserved in bacteria
PP4_RS12715	COG0438	transferase activity, transferring glycosyl groups
PP4_RS12735	COG0583	DNA-binding transcription factor activity
PP4_RS12740	COG1760	l-serine dehydratase
PP4_RS12750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS12760	COG0174	glutamine synthetase
PP4_RS12775	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS12780	COG0583	DNA-binding transcription factor activity
PP4_RS12810	COG1073	alpha beta
PP4_RS12815	COG0583	DNA-binding transcription factor activity
PP4_RS12820	COG4175	Glycine betaine
PP4_RS12825	COG4176	ABC-type proline glycine betaine transport system permease component
PP4_RS12830	COG2113	Glycine betaine
PP4_RS12835	COG4977	sequence-specific DNA binding
PP4_RS12865	COG2814	Major facilitator Superfamily
PP4_RS12870	COG3135	benzoate transporter
PP4_RS12895	COG1278	Cold shock
PP4_RS12900	COG3344	reverse transcriptase
PP4_RS12905	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS12910	COG0667	Aldo Keto reductase
PP4_RS12915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PP4_RS12920	COG2271	Major facilitator Superfamily
PP4_RS12925	COG3835	regulator
PP4_RS12930	COG1929	Belongs to the glycerate kinase type-1 family
PP4_RS12935	COG0583	DNA-binding transcription factor activity
PP4_RS12940	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS12955	COG1999	signal sequence binding
PP4_RS12970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PP4_RS12975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PP4_RS12985	COG0402	S-adenosylhomocysteine deaminase activity
PP4_RS12990	COG2423	ornithine cyclodeaminase activity
PP4_RS12995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PP4_RS13040	COG2837	iron assimilation
PP4_RS13045	COG0667	Aldo Keto reductase
PP4_RS13070	COG2890	protein-(glutamine-N5) methyltransferase activity
PP4_RS13075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PP4_RS13095	COG1051	belongs to the nudix hydrolase family
PP4_RS13125	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS13125	COG2030	dehydratase
PP4_RS13140	COG3162	membrane
PP4_RS13145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PP4_RS13150	COG2151	metal-sulfur cluster biosynthetic enzyme
PP4_RS13155	COG3396	Phenylacetate-CoA oxygenase
PP4_RS13160	COG3460	Phenylacetate-CoA oxygenase
PP4_RS13165	COG3396	Phenylacetate-CoA oxygenase
PP4_RS13175	COG0183	Belongs to the thiolase family
PP4_RS13180	COG2050	protein possibly involved in aromatic compounds catabolism
PP4_RS13185	COG1250	3-hydroxyacyl-CoA dehydrogenase
PP4_RS13190	COG1024	Enoyl-CoA hydratase
PP4_RS13195	COG1024	Enoyl-CoA hydratase
PP4_RS13205	COG3327	negative regulation of DNA-templated transcription, initiation
PP4_RS13210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PP4_RS13225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PP4_RS13260	COG3046	protein related to deoxyribodipyrimidine photolyase
PP4_RS13270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PP4_RS13285	COG1366	Belongs to the anti-sigma-factor antagonist family
PP4_RS13290	COG0789	Transcriptional regulator
PP4_RS13305	COG2801	Transposase and inactivated derivatives
PP4_RS13335	COG2271	Major facilitator Superfamily
PP4_RS13340	COG2721	sulfolactate sulfo-lyase activity
PP4_RS13345	COG2828	Protein conserved in bacteria
PP4_RS13350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PP4_RS13355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PP4_RS13360	COG0583	DNA-binding transcription factor activity
PP4_RS13365	COG3384	dioxygenase
PP4_RS13385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PP4_RS13395	COG0583	DNA-binding transcription factor activity
PP4_RS13400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PP4_RS13405	COG1115	amino acid carrier protein
PP4_RS13410	COG0477	Major facilitator Superfamily
PP4_RS13415	COG0583	DNA-binding transcription factor activity
PP4_RS13425	COG0028	Belongs to the TPP enzyme family
PP4_RS13425	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PP4_RS13430	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13450	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
PP4_RS13470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PP4_RS13475	COG0477	Major facilitator Superfamily
PP4_RS13490	COG0784	Response regulator, receiver
PP4_RS13490	COG4191	Histidine kinase
PP4_RS13495	COG0778	Nitroreductase
PP4_RS13510	COG0300	oxidoreductase activity
PP4_RS13535	COG0183	Belongs to the thiolase family
PP4_RS13545	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS13555	COG0183	Belongs to the thiolase family
PP4_RS13560	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13565	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13570	COG1024	Enoyl-CoA hydratase
PP4_RS13580	COG1024	Enoyl-CoA hydratase
PP4_RS13620	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS13625	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS13645	COG2814	Major facilitator Superfamily
PP4_RS13650	COG2267	carboxylic ester hydrolase activity
PP4_RS13670	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13675	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13680	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13695	COG1960	acyl-CoA dehydrogenase activity
PP4_RS13710	COG1024	Enoyl-CoA hydratase
PP4_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS13750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PP4_RS13765	COG4569	acetaldehyde dehydrogenase (acetylating) activity
PP4_RS13770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PP4_RS13775	COG2814	Major facilitator Superfamily
PP4_RS13790	COG1126	abc transporter atp-binding protein
PP4_RS13795	COG0765	amino acid transport
PP4_RS13800	COG0765	amino acid transport
PP4_RS13815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PP4_RS13840	COG2814	Major facilitator Superfamily
PP4_RS13845	COG0583	DNA-binding transcription factor activity
PP4_RS13850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PP4_RS13895	COG0765	amino acid transport
PP4_RS13900	COG1126	abc transporter atp-binding protein
PP4_RS13905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS13915	COG1522	sequence-specific DNA binding
PP4_RS13920	COG2814	Major facilitator Superfamily
PP4_RS13930	COG0667	Aldo Keto reductase
PP4_RS13935	COG2205	protein histidine kinase activity
PP4_RS13940	COG0745	RESPONSE REGULATOR receiver
PP4_RS13945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PP4_RS13955	COG2356	endonuclease I
PP4_RS13970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PP4_RS13980	COG1609	Transcriptional regulator
PP4_RS14110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS14115	COG0667	Aldo Keto reductase
PP4_RS14120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS14125	COG4771	TonB-dependent receptor
PP4_RS14130	COG1609	Transcriptional regulator
PP4_RS14135	COG0583	DNA-binding transcription factor activity
PP4_RS14140	COG1960	acyl-CoA dehydrogenase activity
PP4_RS14145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PP4_RS14150	COG0235	Class ii aldolase
PP4_RS14155	COG0747	negative chemotaxis
PP4_RS14160	COG0601	transmembrane transport
PP4_RS14165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PP4_RS14180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS14185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS14215	COG3813	Protein conserved in bacteria
PP4_RS14220	COG2197	response regulator
PP4_RS14225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS14225	COG2205	protein histidine kinase activity
PP4_RS14235	COG1609	Transcriptional regulator
PP4_RS14240	COG3265	gluconokinase activity
PP4_RS14255	COG2204	response regulator
PP4_RS14260	COG2205	protein histidine kinase activity
PP4_RS14265	COG5002	protein histidine kinase activity
PP4_RS14270	COG1196	nuclear chromosome segregation
PP4_RS14270	COG0741	lytic transglycosylase activity
PP4_RS14270	COG0739	heme binding
PP4_RS14280	COG1459	type II secretion system
PP4_RS14285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS14305	COG1595	DNA-templated transcription, initiation
PP4_RS14310	COG3712	iron ion homeostasis
PP4_RS14320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS14345	COG0784	Response regulator, receiver
PP4_RS14345	COG4191	Histidine kinase
PP4_RS14365	COG2200	EAL domain
PP4_RS14375	COG1253	flavin adenine dinucleotide binding
PP4_RS14440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PP4_RS14490	COG0488	(ABC) transporter
PP4_RS14505	COG0625	glutathione transferase activity
PP4_RS14525	COG0019	diaminopimelate decarboxylase activity
PP4_RS14550	COG0463	Glycosyl transferase, family 2
PP4_RS14560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PP4_RS14565	COG0579	oxidoreductase
PP4_RS14610	COG1984	allophanate hydrolase subunit 2
PP4_RS14620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PP4_RS14635	COG0307	riboflavin synthase, alpha
PP4_RS14650	COG0113	porphobilinogen synthase activity
PP4_RS14660	COG1113	amino acid transport
PP4_RS14665	COG0579	oxidoreductase
PP4_RS14675	COG1802	Transcriptional regulator
PP4_RS14680	COG0745	RESPONSE REGULATOR receiver
PP4_RS14685	COG2205	protein histidine kinase activity
PP4_RS14690	COG0215	cysteine-tRNA ligase activity
PP4_RS14695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PP4_RS14705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PP4_RS14710	COG2366	antibiotic biosynthetic process
PP4_RS14745	COG2911	Protein conserved in bacteria
PP4_RS14750	COG0729	surface antigen
PP4_RS14760	COG0708	Exodeoxyribonuclease III
PP4_RS14770	COG1595	DNA-templated transcription, initiation
PP4_RS14780	COG3038	cytochrome b561
PP4_RS14785	COG0477	Major facilitator Superfamily
PP4_RS14790	COG1917	Cupin 2, conserved barrel domain protein
PP4_RS14790	COG1396	sequence-specific DNA binding
PP4_RS14805	COG4221	oxidoreductase activity
PP4_RS14845	COG0393	Putative heavy-metal-binding
PP4_RS14855	COG0235	Class ii aldolase
PP4_RS14865	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS14865	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS14875	COG1252	NADH dehydrogenase
PP4_RS14880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PP4_RS14900	COG1968	undecaprenyl-diphosphatase activity
PP4_RS14905	COG0840	transmembrane signaling receptor activity
PP4_RS14960	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PP4_RS14965	COG0830	nickel cation binding
PP4_RS14975	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PP4_RS14980	COG0804	urea catabolic process
PP4_RS14985	COG0832	Belongs to the urease beta subunit family
PP4_RS14990	COG0831	urea catabolic process
PP4_RS14995	COG0829	nickel cation binding
PP4_RS15000	COG4974	Belongs to the 'phage' integrase family
PP4_RS15005	COG1199	ATP-dependent helicase activity
PP4_RS15005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PP4_RS15015	COG2271	Major facilitator Superfamily
PP4_RS15030	COG2721	sulfolactate sulfo-lyase activity
PP4_RS15035	COG0583	DNA-binding transcription factor activity
PP4_RS15045	COG4948	Mandelate Racemase Muconate Lactonizing
PP4_RS15055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS15065	COG3321	synthase
PP4_RS15065	COG0604	alcohol dehydrogenase
PP4_RS15155	COG0556	nucleotide-excision repair
PP4_RS15165	COG2249	NAD(P)H dehydrogenase (quinone) activity
PP4_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS15185	COG0583	DNA-binding transcription factor activity
PP4_RS15205	COG0028	Belongs to the TPP enzyme family
PP4_RS15210	COG0596	Alpha beta hydrolase
PP4_RS15215	COG5002	protein histidine kinase activity
PP4_RS15215	COG5000	phosphorelay sensor kinase activity
PP4_RS15235	COG2080	2 iron, 2 sulfur cluster binding
PP4_RS15240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PP4_RS15245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PP4_RS15250	COG1063	alcohol dehydrogenase
PP4_RS15255	COG0693	protein deglycase activity
PP4_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS15290	COG0784	Response regulator, receiver
PP4_RS15290	COG4191	Histidine kinase
PP4_RS15305	COG2172	sigma factor antagonist activity
PP4_RS15310	COG1366	Belongs to the anti-sigma-factor antagonist family
PP4_RS15315	COG1366	Belongs to the anti-sigma-factor antagonist family
PP4_RS15325	COG3568	Endonuclease Exonuclease Phosphatase
PP4_RS15330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PP4_RS15335	COG0392	lysyltransferase activity
PP4_RS15360	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
PP4_RS15375	COG3706	GGDEF domain
PP4_RS15390	COG1595	DNA-templated transcription, initiation
PP4_RS15400	COG3220	belongs to the UPF0276 family
PP4_RS15425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PP4_RS15450	COG4221	oxidoreductase activity
PP4_RS15460	COG0583	DNA-binding transcription factor activity
PP4_RS15475	COG0668	transmembrane transport
PP4_RS15485	COG0640	Transcriptional regulator
PP4_RS15490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PP4_RS15495	COG0431	NADPH-dependent FMN reductase
PP4_RS15545	COG4993	Dehydrogenase
PP4_RS15560	COG0583	DNA-binding transcription factor activity
PP4_RS15565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PP4_RS15580	COG3119	arylsulfatase activity
PP4_RS15615	COG0714	Associated with various cellular activities
PP4_RS15645	COG2995	paraquat-inducible protein a
PP4_RS15650	COG3008	intermembrane lipid transfer
PP4_RS15660	COG2067	long-chain fatty acid transport protein
PP4_RS15665	COG0741	lytic transglycosylase activity
PP4_RS15710	COG1473	amidohydrolase
PP4_RS15730	COG0678	peroxiredoxin activity
PP4_RS15735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PP4_RS15740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PP4_RS15780	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS15785	COG0010	Belongs to the arginase family
PP4_RS15805	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS15815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PP4_RS15835	COG2308	Evidence 4 Homologs of previously reported genes of
PP4_RS15845	COG1305	Transglutaminase-like
PP4_RS15860	COG3048	D-serine ammonia-lyase activity
PP4_RS15865	COG0583	DNA-binding transcription factor activity
PP4_RS15880	COG2205	protein histidine kinase activity
PP4_RS15880	COG5002	protein histidine kinase activity
PP4_RS15880	COG0784	Response regulator, receiver
PP4_RS15950	COG1131	(ABC) transporter
PP4_RS15970	COG2205	protein histidine kinase activity
PP4_RS15970	COG0784	Response regulator, receiver
PP4_RS15995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PP4_RS16000	COG0581	inorganic phosphate transmembrane transporter activity
PP4_RS16010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PP4_RS16045	COG2271	Major facilitator Superfamily
PP4_RS16065	COG1309	transcriptional regulator
PP4_RS16125	COG1595	DNA-templated transcription, initiation
PP4_RS16170	COG2197	response regulator
PP4_RS16175	COG2205	protein histidine kinase activity
PP4_RS16175	COG4191	Histidine kinase
PP4_RS16175	COG0745	RESPONSE REGULATOR receiver
PP4_RS16185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PP4_RS16195	COG0457	Tetratricopeptide repeat
PP4_RS16195	COG3118	belongs to the thioredoxin family
PP4_RS16200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PP4_RS16205	COG1215	transferase activity, transferring glycosyl groups
PP4_RS16210	COG1215	transferase activity, transferring glycosyl groups
PP4_RS16215	COG1192	Involved in chromosome partitioning
PP4_RS16225	COG2194	sulfuric ester hydrolase activity
PP4_RS16240	COG1132	(ABC) transporter
PP4_RS16245	COG1414	Transcriptional regulator
PP4_RS16250	COG3842	ATPase activity
PP4_RS16255	COG1176	ABC-type spermidine putrescine transport system, permease component I
PP4_RS16260	COG1177	transmembrane transport
PP4_RS16265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PP4_RS16265	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS16275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS16285	COG1414	Transcriptional regulator
PP4_RS16290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PP4_RS16295	COG1053	succinate dehydrogenase
PP4_RS16305	COG1053	succinate dehydrogenase
PP4_RS16345	COG0673	inositol 2-dehydrogenase activity
PP4_RS16355	COG1053	succinate dehydrogenase
PP4_RS16360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PP4_RS16365	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS16375	COG2197	response regulator
PP4_RS16380	COG0531	amino acid
PP4_RS16385	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS16390	COG0583	DNA-binding transcription factor activity
PP4_RS16400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PP4_RS16420	COG0583	DNA-binding transcription factor activity
PP4_RS16430	COG0583	DNA-binding transcription factor activity
PP4_RS16435	COG2814	Major facilitator Superfamily
PP4_RS16445	COG2233	PERMEase
PP4_RS16450	COG4221	oxidoreductase activity
PP4_RS16465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PP4_RS16470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PP4_RS16475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PP4_RS16515	COG2194	sulfuric ester hydrolase activity
PP4_RS16520	COG1309	transcriptional regulator
PP4_RS16540	COG0346	lactoylglutathione lyase activity
PP4_RS16550	COG0477	Major facilitator Superfamily
PP4_RS16555	COG0596	Alpha beta hydrolase
PP4_RS16565	COG0596	Alpha beta hydrolase
PP4_RS16575	COG0210	DNA helicase
PP4_RS16590	COG1595	DNA-templated transcription, initiation
PP4_RS16595	COG3712	iron ion homeostasis
PP4_RS16615	COG4774	siderophore transport
PP4_RS16625	COG1595	DNA-templated transcription, initiation
PP4_RS16630	COG0583	DNA-binding transcription factor activity
PP4_RS16635	COG1301	dicarboxylic acid transport
PP4_RS16645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PP4_RS16650	COG3829	transcription factor binding
PP4_RS16665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS16670	COG0747	negative chemotaxis
PP4_RS16680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS16690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PP4_RS16700	COG0747	negative chemotaxis
PP4_RS16705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS16725	COG1132	(ABC) transporter
PP4_RS16730	COG1132	(ABC) transporter
PP4_RS16735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PP4_RS16750	COG4771	TonB-dependent receptor
PP4_RS16755	COG4206	TonB-dependent receptor
PP4_RS16760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS16765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PP4_RS16770	COG1116	anion transmembrane transporter activity
PP4_RS16795	COG0500	methyltransferase
PP4_RS16800	COG1082	Xylose isomerase domain protein TIM barrel
PP4_RS16800	COG3185	4-Hydroxyphenylpyruvate dioxygenase
PP4_RS16805	COG0477	Major facilitator Superfamily
PP4_RS16810	COG0076	glutamate decarboxylase activity
PP4_RS16815	COG0583	DNA-binding transcription factor activity
PP4_RS16820	COG0217	transcriptional regulatory protein
PP4_RS16825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS16835	COG0583	DNA-binding transcription factor activity
PP4_RS16845	COG4106	trans-aconitate 2-methyltransferase activity
PP4_RS16875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS16885	COG0477	Major facilitator Superfamily
PP4_RS16890	COG0583	DNA-binding transcription factor activity
PP4_RS16905	COG2026	Addiction module toxin, RelE StbE family
PP4_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS16935	COG0583	DNA-binding transcription factor activity
PP4_RS16950	COG2814	Major facilitator Superfamily
PP4_RS16960	COG1064	alcohol dehydrogenase
PP4_RS16965	COG2207	Transcriptional regulator
PP4_RS16975	COG2249	NAD(P)H dehydrogenase (quinone) activity
PP4_RS17005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PP4_RS17020	COG4774	siderophore transport
PP4_RS17035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PP4_RS17040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PP4_RS17070	COG3706	GGDEF domain
PP4_RS17075	COG1192	Involved in chromosome partitioning
PP4_RS17085	COG4774	siderophore transport
PP4_RS17095	COG0477	Major facilitator Superfamily
PP4_RS17115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PP4_RS17120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PP4_RS17150	COG2259	Doxx family
PP4_RS17160	COG3220	belongs to the UPF0276 family
PP4_RS17185	COG0417	DNA replication proofreading
PP4_RS17190	COG2814	Major facilitator Superfamily
PP4_RS17195	COG0583	DNA-binding transcription factor activity
PP4_RS17200	COG0583	DNA-binding transcription factor activity
PP4_RS17255	COG1999	signal sequence binding
PP4_RS17260	COG0316	Belongs to the HesB IscA family
PP4_RS17260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PP4_RS17265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PP4_RS17290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PP4_RS17325	COG2853	Lipoprotein
PP4_RS17335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS17340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS17345	COG2365	Tyrosine phosphatase family
PP4_RS17355	COG2866	Carboxypeptidase
PP4_RS17395	COG4251	negative regulation of phosphorylation
PP4_RS17400	COG0745	RESPONSE REGULATOR receiver
PP4_RS17420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PP4_RS17465	COG0720	synthase
PP4_RS17480	COG2079	MmgE PrpD family protein
PP4_RS17495	COG0372	Belongs to the citrate synthase family
PP4_RS17505	COG1802	Transcriptional regulator
PP4_RS17510	COG0189	ligase activity
PP4_RS17510	COG4067	protein conserved in archaea
PP4_RS17540	COG0589	response to stress
PP4_RS17545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PP4_RS17565	COG1376	ErfK ybiS ycfS ynhG family protein
PP4_RS17565	COG1388	LysM domain
PP4_RS17580	COG4181	ATPase activity
PP4_RS17585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PP4_RS17590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PP4_RS17600	COG2259	Doxx family
PP4_RS17605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PP4_RS17645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PP4_RS17655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PP4_RS17660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PP4_RS17665	COG0740	serine-type endopeptidase activity
PP4_RS17670	COG0544	peptidyl-prolyl cis-trans isomerase activity
PP4_RS17680	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
PP4_RS17710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PP4_RS17725	COG0395	ABC-type sugar transport system, permease component
PP4_RS17735	COG3842	ATPase activity
PP4_RS17740	COG3842	ATPase activity
PP4_RS17745	COG3284	Transcriptional regulator
PP4_RS17755	COG0840	transmembrane signaling receptor activity
PP4_RS17765	COG2186	Transcriptional regulator
PP4_RS17785	COG0583	DNA-binding transcription factor activity
PP4_RS17790	COG0840	transmembrane signaling receptor activity
PP4_RS17795	COG3949	Membrane
PP4_RS17800	COG0251	oxidation-reduction process
PP4_RS17815	COG0730	response to heat
PP4_RS17845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PP4_RS17860	COG3246	L-lysine catabolic process to acetate
PP4_RS17865	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS17900	COG2855	membrane
PP4_RS17915	COG2175	clavaminate synthase activity
PP4_RS17925	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS17950	COG2909	trisaccharide binding
PP4_RS17955	COG1960	acyl-CoA dehydrogenase activity
PP4_RS17960	COG1250	3-hydroxyacyl-CoA dehydrogenase
PP4_RS17960	COG1024	Enoyl-CoA hydratase
PP4_RS17965	COG0183	Belongs to the thiolase family
PP4_RS18045	COG1335	isochorismatase
PP4_RS18060	COG2111	Na H antiporter
PP4_RS18060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PP4_RS18065	COG1006	Multisubunit Na H antiporter MnhC subunit
PP4_RS18070	COG0651	ATP synthesis coupled electron transport
PP4_RS18080	COG2212	antiporter activity
PP4_RS18085	COG1320	monovalent cation:proton antiporter activity
PP4_RS18110	COG1024	Enoyl-CoA hydratase
PP4_RS18115	COG1960	acyl-CoA dehydrogenase activity
PP4_RS18120	COG0183	Belongs to the thiolase family
PP4_RS18130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PP4_RS18145	COG0583	DNA-binding transcription factor activity
PP4_RS18150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PP4_RS18155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PP4_RS18160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PP4_RS18165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS18175	COG0826	peptidase U32
PP4_RS18180	COG2132	Multicopper oxidase
PP4_RS18195	COG1238	metal cluster binding
PP4_RS18200	COG0596	Alpha beta hydrolase
PP4_RS18205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PP4_RS18210	COG2133	pyrroloquinoline quinone binding
PP4_RS18220	COG0010	Belongs to the arginase family
PP4_RS18265	COG0589	response to stress
PP4_RS18275	COG3383	formate dehydrogenase (NAD+) activity
PP4_RS18335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PP4_RS18340	COG0174	glutamine synthetase
PP4_RS18350	COG0583	DNA-binding transcription factor activity
PP4_RS18355	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS18390	COG1953	Uracil, thiamine, allantoin
PP4_RS18400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PP4_RS18405	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PP4_RS18420	COG1230	cation diffusion facilitator family transporter
PP4_RS18450	COG0583	DNA-binding transcription factor activity
PP4_RS18460	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PP4_RS18470	COG0402	S-adenosylhomocysteine deaminase activity
PP4_RS18475	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS18475	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS18505	COG0583	DNA-binding transcription factor activity
PP4_RS18510	COG2249	NAD(P)H dehydrogenase (quinone) activity
PP4_RS18520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PP4_RS18525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PP4_RS18540	COG4566	intracellular signal transduction
PP4_RS18550	COG2853	Lipoprotein
PP4_RS18565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PP4_RS18565	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PP4_RS18585	COG4591	ABC-type transport system involved in lipoprotein release permease component
PP4_RS18590	COG1136	(ABC) transporter
PP4_RS18595	COG4591	ABC-type transport system involved in lipoprotein release permease component
PP4_RS18605	COG0584	glycerophosphoryl diester phosphodiesterase
PP4_RS18610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PP4_RS18615	COG1477	protein flavinylation
PP4_RS18625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PP4_RS18635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PP4_RS18655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PP4_RS18685	COG0183	Belongs to the thiolase family
PP4_RS18690	COG1024	Enoyl-CoA hydratase
PP4_RS18690	COG1250	3-hydroxyacyl-CoA dehydrogenase
PP4_RS18700	COG0589	response to stress
PP4_RS18705	COG0488	(ABC) transporter
PP4_RS18710	COG0741	lytic transglycosylase activity
PP4_RS18720	COG0784	Response regulator, receiver
PP4_RS18720	COG0835	chemotaxis
PP4_RS18735	COG2197	response regulator
PP4_RS18740	COG1597	lipid kinase activity
PP4_RS18755	COG0521	Mo-molybdopterin cofactor biosynthetic process
PP4_RS18775	COG1132	(ABC) transporter
PP4_RS18780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PP4_RS18785	COG0425	Belongs to the sulfur carrier protein TusA family
PP4_RS18790	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PP4_RS18800	COG0840	transmembrane signaling receptor activity
PP4_RS18825	COG0004	ammonium transporteR
PP4_RS18850	COG2197	response regulator
PP4_RS18860	COG3171	Protein conserved in bacteria
PP4_RS18865	COG2027	D-alanyl-D-alanine carboxypeptidase
PP4_RS18875	COG0116	Belongs to the methyltransferase superfamily
PP4_RS18875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PP4_RS18880	COG0167	dihydroorotate dehydrogenase activity
PP4_RS18885	COG1116	anion transmembrane transporter activity
PP4_RS18885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PP4_RS18890	COG3707	response regulator
PP4_RS18895	COG2223	nitrite transmembrane transporter activity
PP4_RS18920	COG0668	transmembrane transport
PP4_RS18935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PP4_RS18950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PP4_RS18965	COG0583	DNA-binding transcription factor activity
PP4_RS18970	COG0019	diaminopimelate decarboxylase activity
PP4_RS18975	COG1595	DNA-templated transcription, initiation
PP4_RS19030	COG2814	Major facilitator Superfamily
PP4_RS19035	COG2188	Transcriptional regulator
PP4_RS19040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PP4_RS19050	COG0789	Transcriptional regulator
PP4_RS19055	COG3237	CsbD-like
PP4_RS19065	COG2851	Citrate transporter
PP4_RS19070	COG1301	dicarboxylic acid transport
PP4_RS19075	COG2828	Protein conserved in bacteria
PP4_RS19080	COG0583	DNA-binding transcription factor activity
PP4_RS19090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PP4_RS19100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PP4_RS19105	COG3135	benzoate transporter
PP4_RS19120	COG0714	Associated with various cellular activities
PP4_RS19150	COG0420	3'-5' exonuclease activity
PP4_RS19165	COG2706	6-phosphogluconolactonase activity
PP4_RS19185	COG0308	aminopeptidase N
PP4_RS19195	COG3139	Protein of unknown function (DUF1315)
PP4_RS19205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PP4_RS19210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PP4_RS19220	COG3038	cytochrome b561
PP4_RS19230	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS19230	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS19285	COG1286	toxin biosynthetic process
PP4_RS19295	COG0285	dihydrofolate synthase activity
PP4_RS19300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PP4_RS19305	COG0135	phosphoribosylanthranilate isomerase activity
PP4_RS19330	COG0473	3-isopropylmalate dehydrogenase activity
PP4_RS19335	COG2226	methyltransferase
PP4_RS19340	COG0066	3-isopropylmalate dehydratase activity
PP4_RS19345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PP4_RS19365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PP4_RS19375	COG2267	carboxylic ester hydrolase activity
PP4_RS19415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PP4_RS19430	COG0556	nucleotide-excision repair
PP4_RS19460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PP4_RS19470	COG0084	hydrolase, TatD family'
PP4_RS19480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PP4_RS19485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PP4_RS19495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PP4_RS19500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PP4_RS19510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PP4_RS19515	COG0416	fatty acid biosynthetic process
PP4_RS19520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PP4_RS19530	COG0424	maF-like protein
PP4_RS19535	COG0616	signal peptide processing
PP4_RS19535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PP4_RS19540	COG0546	phosphoglycolate phosphatase activity
PP4_RS19550	COG1530	ribonuclease E activity
PP4_RS19555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PP4_RS19560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PP4_RS19565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PP4_RS19570	COG2835	tetraacyldisaccharide 4'-kinase activity
PP4_RS19575	COG1663	tetraacyldisaccharide 4'-kinase activity
PP4_RS19580	COG0848	biopolymer transport protein
PP4_RS19585	COG0811	peptide transport
PP4_RS19590	COG0658	competence protein
PP4_RS19590	COG2333	competence protein COMEC
PP4_RS19595	COG0842	Transport permease protein
PP4_RS19600	COG1131	(ABC) transporter
PP4_RS19605	COG0625	glutathione transferase activity
PP4_RS19640	COG3121	Chaperone
PP4_RS19650	COG3188	usher protein
PP4_RS19690	COG1956	GAF domain-containing protein
PP4_RS19700	COG2205	protein histidine kinase activity
PP4_RS19700	COG0784	Response regulator, receiver
PP4_RS19700	COG5002	protein histidine kinase activity
PP4_RS19705	COG0386	Belongs to the glutathione peroxidase family
PP4_RS19710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PP4_RS19715	COG0436	Aminotransferase
PP4_RS19720	COG0501	Belongs to the peptidase M48B family
PP4_RS19725	COG0500	methyltransferase
PP4_RS19730	COG3384	dioxygenase
PP4_RS19745	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PP4_RS19755	COG0583	DNA-binding transcription factor activity
PP4_RS19765	COG0583	DNA-binding transcription factor activity
PP4_RS19770	COG1846	Transcriptional regulator
PP4_RS19775	COG1764	response to oxidative stress
PP4_RS19780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PP4_RS19795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PP4_RS19800	COG0583	DNA-binding transcription factor activity
PP4_RS19805	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS19810	COG2814	Major facilitator Superfamily
PP4_RS19820	COG4773	Receptor
PP4_RS19835	COG0204	Acyl-transferase
PP4_RS19840	COG0598	Magnesium transport protein CorA
PP4_RS19845	COG0519	Catalyzes the synthesis of GMP from XMP
PP4_RS19865	COG1368	sulfuric ester hydrolase activity
PP4_RS19895	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PP4_RS19900	COG2814	Major facilitator Superfamily
PP4_RS19905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PP4_RS19935	COG2840	Smr protein MutS2
PP4_RS19940	COG0302	gtp cyclohydrolase
PP4_RS19950	COG0625	glutathione transferase activity
PP4_RS19955	COG3135	benzoate transporter
PP4_RS19960	COG0840	transmembrane signaling receptor activity
PP4_RS19965	COG0436	Aminotransferase
PP4_RS19970	COG2814	Major facilitator Superfamily
PP4_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS19980	COG2130	NADP-dependent
PP4_RS19985	COG3274	enterobacterial common antigen metabolic process
PP4_RS19990	COG0284	orotidine-5'-phosphate decarboxylase activity
PP4_RS19995	COG1555	photosystem II stabilization
PP4_RS20000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PP4_RS20005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PP4_RS20065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PP4_RS20080	COG0438	transferase activity, transferring glycosyl groups
PP4_RS20105	COG2244	polysaccharide biosynthetic process
PP4_RS20130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PP4_RS20140	COG0776	regulation of translation
PP4_RS20145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PP4_RS20155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PP4_RS20160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PP4_RS20170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PP4_RS20180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PP4_RS20185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PP4_RS20190	COG0546	phosphoglycolate phosphatase activity
PP4_RS20195	COG1028	Short-chain dehydrogenase reductase Sdr
PP4_RS20205	COG5001	Diguanylate cyclase
PP4_RS20205	COG5002	protein histidine kinase activity
PP4_RS20220	COG1054	Belongs to the UPF0176 family
PP4_RS20225	COG0271	Belongs to the BolA IbaG family
PP4_RS20235	COG0114	fumarate hydratase activity
PP4_RS20240	COG0697	spore germination
PP4_RS20245	COG2326	polyphosphate kinase activity
PP4_RS20250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS20250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PP4_RS20255	COG0367	asparagine synthase
PP4_RS20260	COG0189	ligase activity
PP4_RS20260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PP4_RS20265	COG1363	Peptidase, m42
PP4_RS20270	COG3089	Belongs to the UPF0270 family
PP4_RS20275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PP4_RS20290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS20290	COG2205	protein histidine kinase activity
PP4_RS20295	COG2197	response regulator
PP4_RS20320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PP4_RS20325	COG3162	membrane
PP4_RS20330	COG2113	Glycine betaine
PP4_RS20350	COG2853	Lipoprotein
PP4_RS20360	COG1560	Kdo2-lipid A biosynthetic process
PP4_RS20365	COG0850	regulation of cytokinetic process
PP4_RS20370	COG2894	cell division
PP4_RS20375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PP4_RS20380	COG0564	pseudouridine synthase activity
PP4_RS20385	COG1362	aminopeptidase activity
PP4_RS20390	COG0668	transmembrane transport
PP4_RS20410	COG1176	ABC-type spermidine putrescine transport system, permease component I
PP4_RS20440	COG3300	MHYT domain
PP4_RS20440	COG5001	Diguanylate cyclase
PP4_RS20455	COG3339	Conserved Protein
PP4_RS20460	COG0545	Peptidyl-prolyl cis-trans isomerase
PP4_RS20465	COG0583	DNA-binding transcription factor activity
PP4_RS20475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PP4_RS20475	COG2146	nitrite reductase [NAD(P)H] activity
PP4_RS20480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PP4_RS20480	COG2146	nitrite reductase [NAD(P)H] activity
PP4_RS20485	COG0243	molybdopterin cofactor binding
PP4_RS20495	COG0024	Methionine aminopeptidase
PP4_RS20525	COG2974	May be involved in recombination
PP4_RS20530	COG0385	Bile acid
PP4_RS20535	COG2076	Multidrug Resistance protein
PP4_RS20540	COG0477	Major facilitator Superfamily
PP4_RS20545	COG2814	Major facilitator Superfamily
PP4_RS20550	COG2205	protein histidine kinase activity
PP4_RS20580	COG0583	DNA-binding transcription factor activity
PP4_RS20610	COG1846	Transcriptional regulator
PP4_RS20615	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PP4_RS20620	COG0406	alpha-ribazole phosphatase activity
PP4_RS20625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PP4_RS20635	COG1492	cobalamin metabolic process
PP4_RS20650	COG0778	Nitroreductase
PP4_RS20655	COG1797	cobyrinic acid a,c-diamide synthase activity
PP4_RS20675	COG0791	NLP P60 protein
PP4_RS20680	COG0791	NLP P60 protein
PP4_RS20690	COG0628	permease
PP4_RS20700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PP4_RS20705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PP4_RS20720	COG3122	Protein conserved in bacteria
PP4_RS20725	COG3956	TIGRFAM MazG family protein
PP4_RS20730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PP4_RS20735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PP4_RS20755	COG5002	protein histidine kinase activity
PP4_RS20755	COG0784	Response regulator, receiver
PP4_RS20755	COG2205	protein histidine kinase activity
PP4_RS20760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PP4_RS20800	COG0037	tRNA processing
PP4_RS20810	COG3091	SprT-like family
PP4_RS20820	COG0583	DNA-binding transcription factor activity
PP4_RS20835	COG3148	PFAM DTW domain containing protein
PP4_RS20855	COG2137	regulation of response to DNA damage stimulus
PP4_RS20860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PP4_RS20865	COG1546	Belongs to the CinA family
PP4_RS20875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PP4_RS20880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PP4_RS20900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PP4_RS20905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PP4_RS20910	COG0585	pseudouridine synthase activity
PP4_RS20915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PP4_RS20925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PP4_RS20935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PP4_RS20945	COG0148	phosphopyruvate hydratase activity
PP4_RS20950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PP4_RS20955	COG0504	CTP synthase activity
PP4_RS20960	COG0037	tRNA processing
PP4_RS20965	COG0825	malonyl-CoA metabolic process
PP4_RS20975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PP4_RS20980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PP4_RS20985	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PP4_RS20990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PP4_RS20995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PP4_RS21015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PP4_RS21025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PP4_RS21030	COG0233	cytoplasmic translational termination
PP4_RS21035	COG0528	UMP kinase activity
PP4_RS21040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PP4_RS21045	COG0052	Belongs to the universal ribosomal protein uS2 family
PP4_RS21050	COG0024	Methionine aminopeptidase
PP4_RS21055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PP4_RS21060	COG0436	Aminotransferase
PP4_RS21065	COG0025	NhaP-type Na H and K H
PP4_RS21075	COG1393	Belongs to the ArsC family
PP4_RS21080	COG2171	N-acyltransferase activity
PP4_RS21085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PP4_RS21095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PP4_RS21100	COG1215	transferase activity, transferring glycosyl groups
PP4_RS21105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PP4_RS21110	COG2226	methyltransferase
PP4_RS21125	COG2937	Belongs to the GPAT DAPAT family
PP4_RS21145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS21155	COG0742	ribosomal rna small subunit methyltransferase
PP4_RS21190	COG0563	adenylate kinase activity
PP4_RS21195	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PP4_RS21210	COG2885	chlorophyll binding
PP4_RS21220	COG1073	alpha beta
PP4_RS21240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PP4_RS21250	COG4251	negative regulation of phosphorylation
PP4_RS21250	COG3706	GGDEF domain
PP4_RS21250	COG5001	Diguanylate cyclase
PP4_RS21250	COG2203	Gaf domain
PP4_RS21255	COG2201	protein-glutamate methylesterase activity
PP4_RS21270	COG0457	Tetratricopeptide repeat
PP4_RS21270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PP4_RS21280	COG0840	transmembrane signaling receptor activity
PP4_RS21285	COG2979	Protein of unknown function (DUF533)
PP4_RS21290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PP4_RS21295	COG3842	ATPase activity
PP4_RS21300	COG1176	ABC-type spermidine putrescine transport system, permease component I
PP4_RS21305	COG1177	transmembrane transport
PP4_RS21310	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS21315	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS21330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PP4_RS21370	COG4974	Belongs to the 'phage' integrase family
PP4_RS21380	COG1607	acyl-coa hydrolase
PP4_RS21385	COG0335	large ribosomal subunit rRNA binding
PP4_RS21390	COG0336	Belongs to the RNA methyltransferase TrmD family
PP4_RS21395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PP4_RS21400	COG0228	four-way junction DNA binding
PP4_RS21405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PP4_RS21415	COG4536	flavin adenine dinucleotide binding
PP4_RS21420	COG0477	Major facilitator Superfamily
PP4_RS21425	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PP4_RS21445	COG0494	nUDIX hydrolase
PP4_RS21500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PP4_RS21530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PP4_RS21535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PP4_RS21550	COG0047	phosphoribosylformylglycinamidine synthase activity
PP4_RS21550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PP4_RS21555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PP4_RS21560	COG0590	tRNA wobble adenosine to inosine editing
PP4_RS21575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PP4_RS21575	COG0519	Catalyzes the synthesis of GMP from XMP
PP4_RS21595	COG0583	DNA-binding transcription factor activity
PP4_RS21600	COG1570	exodeoxyribonuclease VII activity
PP4_RS21605	COG0739	heme binding
PP4_RS21610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PP4_RS21620	COG0800	Aldolase
PP4_RS21635	COG1737	Transcriptional regulator
PP4_RS21640	COG0676	glucose-6-phosphate 1-epimerase activity
PP4_RS21650	COG3842	ATPase activity
PP4_RS21660	COG1175	transmembrane transport
PP4_RS21705	COG1629	transport
PP4_RS21705	COG4771	TonB-dependent receptor
PP4_RS21715	COG2832	Protein of unknown function (DUF454)
PP4_RS21730	COG2235	arginine
PP4_RS21735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PP4_RS21755	COG0786	glutamate:sodium symporter activity
PP4_RS21760	COG0509	glycine decarboxylation via glycine cleavage system
PP4_RS21765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PP4_RS21765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PP4_RS21770	COG1760	l-serine dehydratase
PP4_RS21775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PP4_RS21780	COG1278	Cold shock
PP4_RS21790	COG0795	lipopolysaccharide-transporting ATPase activity
PP4_RS21795	COG0795	lipopolysaccharide-transporting ATPase activity
PP4_RS21800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PP4_RS21815	COG0525	valine-tRNA ligase activity
PP4_RS21820	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PP4_RS21825	COG0776	regulation of translation
PP4_RS21830	COG3081	Nucleoid-associated protein
PP4_RS21835	COG2827	Endonuclease containing a URI domain
PP4_RS21845	COG2807	transmembrane transport
PP4_RS21850	COG2186	Transcriptional regulator
PP4_RS21860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PP4_RS21865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PP4_RS21870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PP4_RS21875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PP4_RS21895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PP4_RS21900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PP4_RS21905	COG1127	ABC transporter
PP4_RS21915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PP4_RS21925	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PP4_RS21930	COG1137	ATPase activity
PP4_RS21935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PP4_RS21940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PP4_RS21950	COG1660	Displays ATPase and GTPase activities
PP4_RS21955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PP4_RS21985	COG0312	modulator of DNA gyrase
PP4_RS21990	COG3028	Belongs to the UPF0307 family
PP4_RS21995	COG0312	modulator of DNA gyrase
PP4_RS22000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PP4_RS22015	COG0424	maF-like protein
PP4_RS22025	COG1792	Involved in formation and maintenance of cell shape
PP4_RS22030	COG1077	Cell shape determining protein MreB Mrl
PP4_RS22035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PP4_RS22040	COG0154	amidase activity
PP4_RS22045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PP4_RS22060	COG1113	amino acid transport
PP4_RS22070	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PP4_RS22085	COG0747	negative chemotaxis
PP4_RS22090	COG0747	negative chemotaxis
PP4_RS22100	COG0747	negative chemotaxis
PP4_RS22105	COG0601	transmembrane transport
PP4_RS22110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PP4_RS22115	COG0444	Belongs to the ABC transporter superfamily
PP4_RS22120	COG4608	Belongs to the ABC transporter superfamily
PP4_RS22135	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PP4_RS22150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PP4_RS22160	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
PP4_RS22185	COG4772	TonB-dependent receptor
PP4_RS22200	COG0019	diaminopimelate decarboxylase activity
PP4_RS22215	COG3128	pkhd-type hydroxylase
PP4_RS22220	COG4774	siderophore transport
PP4_RS22225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PP4_RS22235	COG0436	Aminotransferase
PP4_RS22245	COG1160	GTP binding
PP4_RS22260	COG0124	histidyl-tRNA synthetase
PP4_RS22265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PP4_RS22280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PP4_RS22285	COG0105	UTP biosynthetic process
PP4_RS22295	COG0633	Ferredoxin
PP4_RS22300	COG0443	Heat shock 70 kDa protein
PP4_RS22305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PP4_RS22310	COG0316	Belongs to the HesB IscA family
PP4_RS22320	COG1104	cysteine desulfurase activity
PP4_RS22330	COG1045	serine acetyltransferase
PP4_RS22345	COG3134	Outer membrane lipoprotein
PP4_RS22360	COG1862	Preprotein translocase
PP4_RS22365	COG0343	queuine tRNA-ribosyltransferase activity
PP4_RS22370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PP4_RS22385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS22410	COG3657	addiction module killer protein
PP4_RS22415	COG3781	membrane
PP4_RS22420	COG3639	organic phosphonate transmembrane transporter activity
PP4_RS22425	COG3639	organic phosphonate transmembrane transporter activity
PP4_RS22430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PP4_RS22435	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PP4_RS22440	COG0709	Synthesizes selenophosphate from selenide and ATP
PP4_RS22445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PP4_RS22460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PP4_RS22465	COG0727	PFAM Uncharacterised protein family (UPF0153)
PP4_RS22475	COG0436	Aminotransferase
PP4_RS22480	COG0109	protoheme IX farnesyltransferase activity
PP4_RS22485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PP4_RS22490	COG1845	cytochrome c oxidase, subunit III
PP4_RS22495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PP4_RS22500	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PP4_RS22505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PP4_RS22510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PP4_RS22510	COG1017	nitric oxide dioxygenase activity
PP4_RS22515	COG3604	Transcriptional regulator
PP4_RS22560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PP4_RS22585	COG5001	Diguanylate cyclase
PP4_RS22585	COG4251	negative regulation of phosphorylation
PP4_RS22585	COG2203	Gaf domain
PP4_RS22585	COG3706	GGDEF domain
PP4_RS22595	COG3530	Putative quorum-sensing-regulated virulence factor
PP4_RS22600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PP4_RS22600	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PP4_RS22600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PP4_RS22605	COG1105	Belongs to the carbohydrate kinase PfkB family
PP4_RS22615	COG1609	Transcriptional regulator
PP4_RS22620	COG0084	hydrolase, TatD family'
PP4_RS22625	COG3725	Membrane protein required for beta-lactamase induction
PP4_RS22630	COG3023	N-Acetylmuramoyl-L-alanine amidase
PP4_RS22645	COG0492	ferredoxin-NADP+ reductase activity
PP4_RS22650	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PP4_RS22670	COG0386	Belongs to the glutathione peroxidase family
PP4_RS22685	COG0280	phosphate acetyltransferase
PP4_RS22685	COG0857	belongs to the CobB CobQ family
PP4_RS22690	COG2885	chlorophyll binding
PP4_RS22695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PP4_RS22730	COG0318	PFAM AMP-dependent synthetase and ligase
PP4_RS22735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PP4_RS22740	COG2813	Specifically methylates the guanine in position
PP4_RS22745	COG2119	membrane
PP4_RS22755	COG2135	peptidase activity
PP4_RS22795	COG0579	oxidoreductase
PP4_RS22815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PP4_RS22820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PP4_RS22830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PP4_RS22835	COG1090	epimerase
PP4_RS22840	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PP4_RS22850	COG0789	Transcriptional regulator
PP4_RS22870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PP4_RS22875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PP4_RS22885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PP4_RS22890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PP4_RS22900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PP4_RS22905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PP4_RS22915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PP4_RS22920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PP4_RS22925	COG0193	aminoacyl-tRNA hydrolase activity
PP4_RS22955	COG0628	permease
PP4_RS22970	COG1335	isochorismatase
PP4_RS22995	COG1511	domain protein
PP4_RS22995	COG3264	Mechanosensitive ion channel
PP4_RS23000	COG2169	Transcriptional regulator
PP4_RS23000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PP4_RS23010	COG1595	DNA-templated transcription, initiation
PP4_RS23025	COG2223	nitrite transmembrane transporter activity
PP4_RS23055	COG0456	acetyltransferase
PP4_RS23080	COG3045	CreA protein
PP4_RS23085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PP4_RS23090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PP4_RS23095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PP4_RS23100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PP4_RS23105	COG0142	geranyltranstransferase activity
PP4_RS23110	COG2824	Alkylphosphonate utilization operon protein PhnA
PP4_RS23120	COG0545	Peptidyl-prolyl cis-trans isomerase
PP4_RS23130	COG2862	Uncharacterized protein family, UPF0114
PP4_RS23140	COG1067	ATP-dependent peptidase activity
PP4_RS23165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PP4_RS23170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PP4_RS23175	COG0488	(ABC) transporter
PP4_RS23190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PP4_RS23200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PP4_RS23215	COG0039	L-malate dehydrogenase activity
PP4_RS23260	COG0582	viral genome integration into host DNA
PP4_RS23285	COG0237	dephospho-CoA kinase activity
PP4_RS23290	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PP4_RS23310	COG1252	NADH dehydrogenase
PP4_RS23340	COG0542	response to heat
PP4_RS23365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS23395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PP4_RS23400	COG1047	Peptidyl-prolyl cis-trans
PP4_RS23405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PP4_RS23410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PP4_RS23415	COG0196	riboflavin kinase activity
PP4_RS23425	COG0268	Binds directly to 16S ribosomal RNA
PP4_RS23430	COG3008	intermembrane lipid transfer
PP4_RS23435	COG2995	paraquat-inducible protein a
PP4_RS23440	COG2995	paraquat-inducible protein a
PP4_RS23470	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PP4_RS23475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PP4_RS23480	COG1183	phosphatidylcholine synthase activity
PP4_RS23485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PP4_RS23495	COG0028	Belongs to the TPP enzyme family
PP4_RS23500	COG3098	single-species biofilm formation
PP4_RS23510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PP4_RS23530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PP4_RS23535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PP4_RS23540	COG4558	Periplasmic binding protein
PP4_RS23550	COG1489	DNA binding
PP4_RS23555	COG0436	Aminotransferase
PP4_RS23565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PP4_RS23575	COG4191	Histidine kinase
PP4_RS23585	COG0617	tRNA 3'-terminal CCA addition
PP4_RS23595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PP4_RS23600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PP4_RS23605	COG0166	Belongs to the GPI family
PP4_RS23610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PP4_RS23635	COG2823	Periplasmic or secreted lipoprotein
PP4_RS23645	COG1185	polyribonucleotide nucleotidyltransferase activity
PP4_RS23650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PP4_RS23655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PP4_RS23660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PP4_RS23665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PP4_RS23670	COG0195	Participates in both transcription termination and antitermination
PP4_RS23675	COG0779	Required for maturation of 30S ribosomal subunits
PP4_RS23690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PP4_RS23695	COG0149	triose-phosphate isomerase activity
PP4_RS23700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PP4_RS23705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PP4_RS23715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PP4_RS23730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PP4_RS23735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PP4_RS23740	COG0505	Belongs to the CarA family
PP4_RS23745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PP4_RS23750	COG0484	heat shock protein binding
PP4_RS23755	COG0443	Heat shock 70 kDa protein
PP4_RS23760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PP4_RS23765	COG0497	DNA recombination
PP4_RS23770	COG0735	belongs to the Fur family
PP4_RS23775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PP4_RS23785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PP4_RS23795	COG1620	l-lactate permease
PP4_RS23800	COG1304	FMN binding
PP4_RS23850	COG0765	amino acid transport
PP4_RS23855	COG1126	abc transporter atp-binding protein
PP4_RS23860	COG0006	proline dipeptidase activity
PP4_RS23865	COG1902	pentaerythritol trinitrate reductase activity
PP4_RS23865	COG0446	pyridine nucleotide-disulphide oxidoreductase
PP4_RS23875	COG4774	siderophore transport
PP4_RS23885	COG0477	Major facilitator Superfamily
PP4_RS23915	COG1609	Transcriptional regulator
PP4_RS23920	COG3321	synthase
PP4_RS23920	COG0604	alcohol dehydrogenase
PP4_RS23925	COG0546	phosphoglycolate phosphatase activity
PP4_RS23930	COG1946	Acyl-CoA thioesterase
PP4_RS23945	COG0123	including yeast histone deacetylase and acetoin utilization protein
PP4_RS23955	COG0513	Belongs to the DEAD box helicase family
PP4_RS23960	COG0697	spore germination
PP4_RS23975	COG3416	Protein conserved in bacteria
PP4_RS24025	COG2207	Transcriptional regulator
PP4_RS24100	COG1643	Atp-dependent helicase
PP4_RS24125	COG1643	Atp-dependent helicase
PP4_RS24170	COG0515	serine threonine protein kinase
PP4_RS24170	COG0457	Tetratricopeptide repeat
PP4_RS24205	COG0840	transmembrane signaling receptor activity
PP4_RS24255	COG2814	Major facilitator Superfamily
PP4_RS24265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PP4_RS24345	COG1643	Atp-dependent helicase
PP4_RS24365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PP4_RS24390	COG1643	Atp-dependent helicase
PP4_RS24410	COG1522	sequence-specific DNA binding
PP4_RS24425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PP4_RS24430	COG1960	acyl-CoA dehydrogenase activity
PP4_RS24445	COG2205	protein histidine kinase activity
PP4_RS24445	COG3850	Histidine kinase
PP4_RS24445	COG4999	Histidine kinase
PP4_RS24445	COG3437	response regulator, receiver
PP4_RS24450	COG0351	phosphomethylpyrimidine kinase
PP4_RS24455	COG0352	thiamine-phosphate diphosphorylase activity
PP4_RS24460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PP4_RS24475	COG1702	phosphate starvation-inducible protein PhoH
PP4_RS24480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PP4_RS24485	COG4535	Mg2 and Co2 transporter CorC
PP4_RS24490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PP4_RS24505	COG0495	leucyl-tRNA aminoacylation
PP4_RS24525	COG2951	lytic endotransglycosylase activity
PP4_RS24530	COG1619	proteins homologs of microcin C7 resistance protein MccF
PP4_RS24535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PP4_RS24540	COG0321	lipoyl(octanoyl) transferase activity
PP4_RS24545	COG2921	Belongs to the UPF0250 family
PP4_RS24550	COG1686	Belongs to the peptidase S11 family
PP4_RS24560	COG2951	lytic endotransglycosylase activity
PP4_RS24565	COG0772	Belongs to the SEDS family
PP4_RS24570	COG0768	penicillin binding
PP4_RS24575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PP4_RS24585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PP4_RS24590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PP4_RS24595	COG2094	Belongs to the DNA glycosylase MPG family
PP4_RS24600	COG0586	Pfam SNARE associated Golgi protein
PP4_RS24610	COG1346	cytolysis
PP4_RS24625	COG2264	protein methyltransferase activity
PP4_RS24635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PP4_RS24645	COG0138	bifunctional purine biosynthesis protein purh
PP4_RS24650	COG0151	Belongs to the GarS family
PP4_RS24660	COG2095	MarC family integral membrane protein
PP4_RS24695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PP4_RS24705	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PP4_RS24720	COG0330	HflC and HflK could
PP4_RS24740	COG4771	TonB-dependent receptor
PP4_RS24750	COG1113	amino acid transport
PP4_RS24770	COG0411	ABC transporter
PP4_RS24785	COG0789	Transcriptional regulator
PP4_RS24790	COG0484	heat shock protein binding
PP4_RS24795	COG0443	Heat shock 70 kDa protein
PP4_RS24815	COG0697	spore germination
PP4_RS24820	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PP4_RS24835	COG2982	Protein involved in outer membrane biogenesis
PP4_RS24855	COG4221	oxidoreductase activity
PP4_RS24885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PP4_RS24890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PP4_RS24905	COG1032	radical SAM domain protein
PP4_RS24915	COG0305	Participates in initiation and elongation during chromosome replication
PP4_RS24920	COG0359	binds to the 23S rRNA
PP4_RS24930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PP4_RS24935	COG0360	Binds together with S18 to 16S ribosomal RNA
PP4_RS24940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PP4_RS24945	COG0557	exoribonuclease II activity
PP4_RS24960	COG1840	ABC-type Fe3 transport system, periplasmic component
PP4_RS24965	COG1178	ABC-type Fe3 transport system permease component
PP4_RS24975	COG0840	transmembrane signaling receptor activity
PP4_RS24980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PP4_RS24985	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PP4_RS24990	COG0330	HflC and HflK could
PP4_RS24995	COG0330	HflC and HflK could
PP4_RS25000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PP4_RS25005	COG1923	regulation of RNA biosynthetic process
PP4_RS25010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PP4_RS25015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PP4_RS25020	COG0860	N-Acetylmuramoyl-L-alanine amidase
PP4_RS25025	COG0802	atpase or kinase
PP4_RS25030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PP4_RS25030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PP4_RS25040	COG2860	membrane
PP4_RS25045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PP4_RS25050	COG1162	GTPase activity
PP4_RS25060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PP4_RS25075	COG0688	phosphatidylethanolamine metabolic process
PP4_RS25080	COG3830	Belongs to the UPF0237 family
PP4_RS25080	COG0560	Phosphoserine phosphatase
PP4_RS25100	COG3577	Aspartyl protease
PP4_RS25115	COG3150	esterase
PP4_RS25120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PP4_RS25130	COG0494	nUDIX hydrolase
PP4_RS25145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PP4_RS25150	COG1538	Outer membrane efflux protein
PP4_RS25155	COG1519	Transferase
PP4_RS25165	COG0583	DNA-binding transcription factor activity
PP4_RS25180	COG0667	Aldo Keto reductase
PP4_RS25190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PP4_RS25190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PP4_RS25195	COG1132	(ABC) transporter
PP4_RS25210	COG0438	transferase activity, transferring glycosyl groups
PP4_RS25235	COG0438	transferase activity, transferring glycosyl groups
PP4_RS25240	COG2192	nodulation
PP4_RS25245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PP4_RS25250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PP4_RS25255	COG0506	proline dehydrogenase activity
PP4_RS25255	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PP4_RS25255	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PP4_RS25270	COG1960	acyl-CoA dehydrogenase activity
PP4_RS25280	COG0312	modulator of DNA gyrase
PP4_RS25285	COG0477	Major facilitator Superfamily
PP4_RS25290	COG0513	Belongs to the DEAD box helicase family
PP4_RS25295	COG2081	HI0933 family
PP4_RS25300	COG1289	transmembrane transporter activity
PP4_RS25305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS25310	COG2153	protein acetylation
PP4_RS25320	COG1451	nucleotide metabolic process
PP4_RS25345	COG0126	phosphoglycerate kinase activity
PP4_RS25350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PP4_RS25360	COG0640	Transcriptional regulator
PP4_RS25365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PP4_RS25370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PP4_RS25410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PP4_RS25415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PP4_RS25435	COG0513	Belongs to the DEAD box helicase family
PP4_RS25440	COG2353	YceI-like domain
PP4_RS25445	COG3038	cytochrome b561
PP4_RS25465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PP4_RS25470	COG1272	protein, Hemolysin III
PP4_RS25480	COG0784	Response regulator, receiver
PP4_RS25480	COG0784	Response regulator, receiver
PP4_RS25480	COG0643	Histidine kinase
PP4_RS25480	COG2198	Histidine kinase
PP4_RS25480	COG2198	Histidine kinase
PP4_RS25480	COG0643	Histidine kinase
PP4_RS25505	COG0189	ligase activity
PP4_RS25515	COG1678	Uncharacterized ACR, COG1678
PP4_RS25520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PP4_RS25525	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PP4_RS25530	COG0540	Belongs to the ATCase OTCase family
PP4_RS25535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PP4_RS25540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PP4_RS25545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PP4_RS25595	COG2226	methyltransferase
PP4_RS25605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PP4_RS25610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PP4_RS25615	COG0140	phosphoribosyl-ATP diphosphatase activity
PP4_RS25620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PP4_RS25640	COG0840	transmembrane signaling receptor activity
PP4_RS25645	COG0840	transmembrane signaling receptor activity
PP4_RS25650	COG1126	abc transporter atp-binding protein
PP4_RS25655	COG0765	amino acid transport
PP4_RS25665	COG2943	transferase activity, transferring hexosyl groups
PP4_RS25670	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PP4_RS25675	COG1490	D-aminoacyl-tRNA deacylase activity
PP4_RS25690	COG1228	amidohydrolase
PP4_RS25700	COG2986	histidine ammonia-lyase
PP4_RS25705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PP4_RS25715	COG2188	Transcriptional regulator
PP4_RS25720	COG0402	S-adenosylhomocysteine deaminase activity
PP4_RS25740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PP4_RS25745	COG0058	SHG alpha-glucan phosphorylase activity
PP4_RS25755	COG1217	gtp-binding protein TYPA
PP4_RS25760	COG0301	tRNA thio-modification
PP4_RS25760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PP4_RS25770	COG3852	Histidine kinase
PP4_RS25785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PP4_RS25790	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PP4_RS25800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PP4_RS25805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PP4_RS25810	COG4942	peptidase
PP4_RS25815	COG0793	Belongs to the peptidase S41A family
PP4_RS25820	COG2861	carbohydrate metabolic process
PP4_RS25825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PP4_RS25830	COG1309	transcriptional regulator
PP4_RS25835	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS25840	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PP4_RS25850	COG3263	regulation of cellular component size
PP4_RS25855	COG1196	nuclear chromosome segregation
PP4_RS25855	COG3264	Mechanosensitive ion channel
PP4_RS25860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PP4_RS25865	COG3118	belongs to the thioredoxin family
PP4_RS25880	COG1192	Involved in chromosome partitioning
PP4_RS25885	COG0583	DNA-binding transcription factor activity
PP4_RS25890	COG2814	Major facilitator Superfamily
PP4_RS25900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PP4_RS25905	COG0493	'glutamate synthase
PP4_RS25910	COG0070	glutamate synthase
PP4_RS25910	COG0069	glutamate synthase activity
PP4_RS25910	COG0067	glutamate synthase
PP4_RS25920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PP4_RS25925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PP4_RS25955	COG0281	malic enzyme
PP4_RS25965	COG0254	rRNA binding
PP4_RS25970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PP4_RS25975	COG0018	arginyl-trna synthetase
PP4_RS25990	COG0791	NLP P60 protein
PP4_RS26015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PP4_RS26020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PP4_RS26020	COG2813	Specifically methylates the guanine in position
PP4_RS26030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PP4_RS26035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PP4_RS26045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PP4_RS26050	COG2022	thiamine diphosphate biosynthetic process
PP4_RS26060	COG2363	Small membrane protein
PP4_RS26065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PP4_RS26075	COG2177	Part of the ABC transporter FtsEX involved in
PP4_RS26080	COG2884	Cell division ATP-binding protein ftsE
PP4_RS26085	COG0552	protein localization to endoplasmic reticulum
PP4_RS26090	COG0612	Peptidase, M16
PP4_RS26095	COG0612	Peptidase, M16
PP4_RS26100	COG0742	ribosomal rna small subunit methyltransferase
PP4_RS26130	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PP4_RS26135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PP4_RS26140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PP4_RS26145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PP4_RS26155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PP4_RS26160	COG0129	dihydroxy-acid dehydratase activity
PP4_RS26170	COG1823	symporter activity
PP4_RS26185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PP4_RS26195	COG1840	ABC-type Fe3 transport system, periplasmic component
PP4_RS26200	COG1178	ABC-type Fe3 transport system permease component
PP4_RS26205	COG3842	ATPase activity
PP4_RS26225	COG0789	Transcriptional regulator
PP4_RS26230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PP4_RS26235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PP4_RS26240	COG0730	response to heat
PP4_RS26250	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PP4_RS26255	COG0494	nUDIX hydrolase
PP4_RS26270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PP4_RS26275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PP4_RS26280	COG3204	pilus organization
PP4_RS26285	COG3204	pilus organization
PP4_RS26290	COG0179	Fumarylacetoacetate (FAA) hydrolase
PP4_RS26295	COG0277	FAD linked oxidase domain protein
PP4_RS26300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PP4_RS26310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS26315	COG1683	Conserved Protein
PP4_RS26350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PP4_RS26355	COG1126	abc transporter atp-binding protein
PP4_RS26360	COG0765	amino acid transport
PP4_RS26365	COG0765	amino acid transport
PP4_RS26375	COG3829	transcription factor binding
PP4_RS26400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PP4_RS26405	COG4208	sulfate ABC transporter
PP4_RS26415	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PP4_RS26425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PP4_RS26450	COG1177	transmembrane transport
PP4_RS26455	COG1176	ABC-type spermidine putrescine transport system, permease component I
PP4_RS26460	COG3842	ATPase activity
PP4_RS26480	COG0174	glutamine synthetase
PP4_RS26485	COG0174	glutamine synthetase
PP4_RS26490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PP4_RS26490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PP4_RS26495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PP4_RS26505	COG1522	sequence-specific DNA binding
PP4_RS26525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PP4_RS26525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PP4_RS26530	COG0509	glycine decarboxylation via glycine cleavage system
PP4_RS26535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PP4_RS26540	COG1178	ABC-type Fe3 transport system permease component
PP4_RS26550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PP4_RS26560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PP4_RS26565	COG0006	proline dipeptidase activity
PP4_RS26570	COG3079	Belongs to the UPF0149 family
PP4_RS26585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PP4_RS26595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PP4_RS26600	COG1129	ABC transporter
PP4_RS26600	COG0842	Transport permease protein
PP4_RS26605	COG0842	Transport permease protein
PP4_RS26630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PP4_RS26640	COG3657	addiction module killer protein
PP4_RS26655	COG0248	Ppx GppA phosphatase
PP4_RS26660	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PP4_RS26675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PP4_RS26680	COG1671	Belongs to the UPF0178 family
PP4_RS26690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PP4_RS26700	COG1965	Belongs to the frataxin family
PP4_RS26710	COG0019	diaminopimelate decarboxylase activity
PP4_RS26715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PP4_RS26725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PP4_RS26730	COG0546	phosphoglycolate phosphatase activity
PP4_RS26740	COG0004	ammonium transporteR
PP4_RS26745	COG0347	Belongs to the P(II) protein family
PP4_RS26765	COG0606	chelatase, subunit chli
PP4_RS26780	COG1335	isochorismatase
PP4_RS26785	COG0583	DNA-binding transcription factor activity
PP4_RS26800	COG1335	isochorismatase
PP4_RS26810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS26815	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS26820	COG0583	DNA-binding transcription factor activity
PP4_RS26825	COG5383	Protein conserved in bacteria
PP4_RS26835	COG0534	Mate efflux family protein
PP4_RS26850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PP4_RS26855	COG0427	acetyl-CoA hydrolase
PP4_RS26870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PP4_RS26875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS26890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PP4_RS26900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PP4_RS26905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PP4_RS26915	COG1012	belongs to the aldehyde dehydrogenase family
PP4_RS26925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PP4_RS26930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PP4_RS26935	COG0747	negative chemotaxis
PP4_RS26940	COG2003	Belongs to the UPF0758 family
PP4_RS26945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PP4_RS26950	COG0756	dUTP diphosphatase activity
PP4_RS26955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PP4_RS26960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PP4_RS26965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PP4_RS26970	COG0708	Exodeoxyribonuclease III
PP4_RS26975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PP4_RS26980	COG1561	YicC-like family, N-terminal region
PP4_RS26985	COG0194	GDP metabolic process
PP4_RS26995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PP4_RS27000	COG0174	glutamine synthetase
PP4_RS27010	COG1758	RNA polymerase activity
PP4_RS27015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PP4_RS27040	COG0848	biopolymer transport protein
PP4_RS27050	COG0583	DNA-binding transcription factor activity
PP4_RS27055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PP4_RS27085	COG3161	chorismate lyase activity
PP4_RS27090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PP4_RS27115	COG1253	flavin adenine dinucleotide binding
PP4_RS27120	COG0739	heme binding
PP4_RS27130	COG0704	Plays a role in the regulation of phosphate uptake
PP4_RS27135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PP4_RS27140	COG0581	inorganic phosphate transmembrane transporter activity
PP4_RS27155	COG0477	Major facilitator Superfamily
PP4_RS27160	COG1607	acyl-coa hydrolase
PP4_RS27190	COG0583	DNA-binding transcription factor activity
PP4_RS27195	COG1027	Aspartate ammonia-lyase
PP4_RS27235	COG0511	ligase activity, forming carbon-carbon bonds
PP4_RS27235	COG5016	pyruvate
PP4_RS27240	COG0439	Biotin carboxylase
PP4_RS27245	COG0583	DNA-binding transcription factor activity
PP4_RS27255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PP4_RS27265	COG0210	DNA helicase
PP4_RS27280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PP4_RS27280	COG4651	solute:proton antiporter activity
PP4_RS27290	COG1607	acyl-coa hydrolase
PP4_RS27295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PP4_RS27305	COG0523	cobalamin synthesis protein
PP4_RS27325	COG1469	GTP cyclohydrolase I activity
PP4_RS27335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PP4_RS27340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PP4_RS27345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PP4_RS27350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PP4_RS27355	COG1349	DNA-binding transcription factor activity
PP4_RS27360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PP4_RS27365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PP4_RS27370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PP4_RS27375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PP4_RS27380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PP4_RS27385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PP4_RS27390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PP4_RS27400	COG0356	it plays a direct role in the translocation of protons across the membrane
PP4_RS27405	COG3312	ion transport
PP4_RS27410	COG1475	DNA binding
PP4_RS27415	COG1192	Involved in chromosome partitioning
PP4_RS27420	COG0357	Ribosomal RNA small subunit methyltransferase G
PP4_RS27425	COG0445	tRNA wobble uridine modification
PP4_RS27430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PP4_RS27435	COG0706	membrane insertase activity