locus-tag	class	description
YSA_RS00025	COG1475	DNA binding
YSA_RS00030	COG1192	Involved in chromosome partitioning
YSA_RS00085	COG3485	protocatechuate 3,4-dioxygenase
YSA_RS00095	COG2814	Major facilitator Superfamily
YSA_RS00100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
YSA_RS00115	COG0789	Transcriptional regulator
YSA_RS00180	COG1475	DNA binding
YSA_RS00185	COG1570	exodeoxyribonuclease VII activity
YSA_RS00250	COG3692	DNA binding
YSA_RS00290	COG0582	viral genome integration into host DNA
YSA_RS00370	COG1733	regulation of RNA biosynthetic process
YSA_RS00380	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS00385	COG0667	Aldo Keto reductase
YSA_RS00420	COG0589	response to stress
YSA_RS00430	COG0583	DNA-binding transcription factor activity
YSA_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS00555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
YSA_RS00620	COG0488	(ABC) transporter
YSA_RS00625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YSA_RS00635	COG0583	DNA-binding transcription factor activity
YSA_RS00640	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
YSA_RS00660	COG3064	Membrane
YSA_RS00705	COG1309	transcriptional regulator
YSA_RS00715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YSA_RS00725	COG3257	ureidoglycine aminohydrolase activity
YSA_RS00735	COG1522	sequence-specific DNA binding
YSA_RS00740	COG2423	ornithine cyclodeaminase activity
YSA_RS00745	COG0583	DNA-binding transcription factor activity
YSA_RS00750	COG0405	Gamma-glutamyltransferase
YSA_RS00760	COG2207	Transcriptional regulator
YSA_RS00765	COG0789	Transcriptional regulator
YSA_RS00775	COG1285	pathogenesis
YSA_RS00785	COG0348	domain, Protein
YSA_RS00790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS00800	COG0784	Response regulator, receiver
YSA_RS00800	COG4191	Histidine kinase
YSA_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS00825	COG1566	PFAM secretion protein HlyD family protein
YSA_RS00830	COG1846	Transcriptional regulator
YSA_RS00835	COG4566	intracellular signal transduction
YSA_RS00845	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS00850	COG1960	acyl-CoA dehydrogenase activity
YSA_RS00860	COG2056	Na+-H+ antiporter family
YSA_RS00870	COG0840	transmembrane signaling receptor activity
YSA_RS00880	COG4176	ABC-type proline glycine betaine transport system permease component
YSA_RS00910	COG1280	lysine exporter protein (LysE YggA)
YSA_RS00915	COG2814	Major facilitator Superfamily
YSA_RS00920	COG0583	DNA-binding transcription factor activity
YSA_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS00975	COG4774	siderophore transport
YSA_RS00980	COG3712	iron ion homeostasis
YSA_RS00985	COG1595	DNA-templated transcription, initiation
YSA_RS01035	COG2814	Major facilitator Superfamily
YSA_RS01040	COG0814	amino acid
YSA_RS01075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS01080	COG1126	abc transporter atp-binding protein
YSA_RS01095	COG0784	Response regulator, receiver
YSA_RS01095	COG2205	protein histidine kinase activity
YSA_RS01125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YSA_RS01130	COG0581	inorganic phosphate transmembrane transporter activity
YSA_RS01140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YSA_RS01170	COG2271	Major facilitator Superfamily
YSA_RS01185	COG1522	sequence-specific DNA binding
YSA_RS01245	COG0454	-acetyltransferase
YSA_RS01270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YSA_RS01275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YSA_RS01280	COG3118	belongs to the thioredoxin family
YSA_RS01280	COG0457	Tetratricopeptide repeat
YSA_RS01285	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YSA_RS01290	COG1215	transferase activity, transferring glycosyl groups
YSA_RS01310	COG2194	sulfuric ester hydrolase activity
YSA_RS01325	COG1132	(ABC) transporter
YSA_RS01420	COG1414	Transcriptional regulator
YSA_RS01425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YSA_RS01430	COG1053	succinate dehydrogenase
YSA_RS01440	COG1053	succinate dehydrogenase
YSA_RS01455	COG0673	inositol 2-dehydrogenase activity
YSA_RS01465	COG1053	succinate dehydrogenase
YSA_RS01470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YSA_RS01475	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS01490	COG0531	amino acid
YSA_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS01525	COG2194	sulfuric ester hydrolase activity
YSA_RS01535	COG3008	intermembrane lipid transfer
YSA_RS01540	COG2995	paraquat-inducible protein a
YSA_RS01560	COG0346	lactoylglutathione lyase activity
YSA_RS01570	COG0477	Major facilitator Superfamily
YSA_RS01580	COG0596	Alpha beta hydrolase
YSA_RS01590	COG0210	DNA helicase
YSA_RS01645	COG1082	Xylose isomerase domain protein TIM barrel
YSA_RS01645	COG3185	4-Hydroxyphenylpyruvate dioxygenase
YSA_RS01650	COG0477	Major facilitator Superfamily
YSA_RS01655	COG0076	glutamate decarboxylase activity
YSA_RS01660	COG0583	DNA-binding transcription factor activity
YSA_RS01665	COG0217	transcriptional regulatory protein
YSA_RS01670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS01675	COG2814	Major facilitator Superfamily
YSA_RS01680	COG0583	DNA-binding transcription factor activity
YSA_RS01690	COG4106	trans-aconitate 2-methyltransferase activity
YSA_RS01705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS01745	COG0625	glutathione transferase activity
YSA_RS01750	COG2814	Major facilitator Superfamily
YSA_RS01755	COG0583	DNA-binding transcription factor activity
YSA_RS01760	COG1309	transcriptional regulator
YSA_RS01765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
YSA_RS01790	COG2873	o-acetylhomoserine
YSA_RS01810	COG1418	mRNA catabolic process
YSA_RS01820	COG2066	Belongs to the glutaminase family
YSA_RS01830	COG3384	dioxygenase
YSA_RS01840	COG0583	DNA-binding transcription factor activity
YSA_RS01845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YSA_RS01850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YSA_RS01855	COG2828	Protein conserved in bacteria
YSA_RS01865	COG0302	gtp cyclohydrolase
YSA_RS01930	COG1942	4-Oxalocrotonate Tautomerase
YSA_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS01965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YSA_RS01970	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS01980	COG1522	sequence-specific DNA binding
YSA_RS01985	COG3608	succinylglutamate desuccinylase aspartoacylase
YSA_RS01990	COG0006	proline dipeptidase activity
YSA_RS01995	COG2423	ornithine cyclodeaminase activity
YSA_RS02000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YSA_RS02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS02010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS02015	COG0765	amino acid transport
YSA_RS02020	COG0765	amino acid transport
YSA_RS02025	COG1126	abc transporter atp-binding protein
YSA_RS02065	COG0659	secondary active sulfate transmembrane transporter activity
YSA_RS02080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YSA_RS02095	COG0640	Transcriptional regulator
YSA_RS02100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YSA_RS02105	COG0798	PFAM Bile acid sodium symporter
YSA_RS02110	COG0431	NADPH-dependent FMN reductase
YSA_RS02120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YSA_RS02150	COG1294	oxidase, subunit
YSA_RS02250	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS02260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YSA_RS02275	COG2826	transposase and inactivated derivatives, IS30 family
YSA_RS02295	COG1192	Involved in chromosome partitioning
YSA_RS02340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YSA_RS02605	COG1358	cellular component organization or biogenesis
YSA_RS02655	COG0776	regulation of translation
YSA_RS02660	COG0072	phenylalanine-tRNA ligase activity
YSA_RS02665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YSA_RS02670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
YSA_RS02675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
YSA_RS02680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
YSA_RS02685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YSA_RS02695	COG1278	Cold shock
YSA_RS02720	COG1869	D-ribose catabolic process
YSA_RS02725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YSA_RS02730	COG1609	Transcriptional regulator
YSA_RS02735	COG1172	Belongs to the binding-protein-dependent transport system permease family
YSA_RS02740	COG1129	ABC transporter
YSA_RS02750	COG0252	asparaginase activity
YSA_RS02755	COG3604	Transcriptional regulator
YSA_RS02760	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
YSA_RS02765	COG2116	formate transmembrane transporter activity
YSA_RS02780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YSA_RS02800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS02815	COG1253	flavin adenine dinucleotide binding
YSA_RS02825	COG0583	DNA-binding transcription factor activity
YSA_RS02830	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
YSA_RS02835	COG3132	Protein of unknown function, DUF480
YSA_RS02855	COG3634	alkyl hydroperoxide reductase activity
YSA_RS02865	COG0861	Integral membrane protein TerC family
YSA_RS02880	COG1104	cysteine desulfurase activity
YSA_RS02885	COG5654	RES domain protein
YSA_RS02890	COG5642	Protein of unknown function (DUF2384)
YSA_RS02900	COG0583	DNA-binding transcription factor activity
YSA_RS02915	COG2814	Major facilitator Superfamily
YSA_RS02925	COG1064	alcohol dehydrogenase
YSA_RS02930	COG2207	Transcriptional regulator
YSA_RS02945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YSA_RS02955	COG4774	siderophore transport
YSA_RS02970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YSA_RS02975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YSA_RS02995	COG1192	Involved in chromosome partitioning
YSA_RS03000	COG0477	Major facilitator Superfamily
YSA_RS03020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YSA_RS03025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YSA_RS03060	COG2259	Doxx family
YSA_RS03070	COG3220	belongs to the UPF0276 family
YSA_RS03095	COG0417	DNA replication proofreading
YSA_RS03100	COG2814	Major facilitator Superfamily
YSA_RS03105	COG0583	DNA-binding transcription factor activity
YSA_RS03110	COG0583	DNA-binding transcription factor activity
YSA_RS03160	COG1999	signal sequence binding
YSA_RS03165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
YSA_RS03165	COG0316	Belongs to the HesB IscA family
YSA_RS03170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YSA_RS03215	COG2814	Major facilitator Superfamily
YSA_RS03220	COG2223	nitrite transmembrane transporter activity
YSA_RS03225	COG2207	Transcriptional regulator
YSA_RS03230	COG2866	Carboxypeptidase
YSA_RS03270	COG4251	negative regulation of phosphorylation
YSA_RS03275	COG0745	RESPONSE REGULATOR receiver
YSA_RS03295	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YSA_RS03310	COG0517	IMP dehydrogenase activity
YSA_RS03310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
YSA_RS03310	COG0617	tRNA 3'-terminal CCA addition
YSA_RS03340	COG0720	synthase
YSA_RS03360	COG2079	MmgE PrpD family protein
YSA_RS03375	COG0372	Belongs to the citrate synthase family
YSA_RS03385	COG1802	Transcriptional regulator
YSA_RS03390	COG4067	protein conserved in archaea
YSA_RS03390	COG0189	ligase activity
YSA_RS03425	COG0589	response to stress
YSA_RS03430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YSA_RS03435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YSA_RS03450	COG1376	ErfK ybiS ycfS ynhG family protein
YSA_RS03450	COG1388	LysM domain
YSA_RS03465	COG4181	ATPase activity
YSA_RS03470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YSA_RS03475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YSA_RS03485	COG2259	Doxx family
YSA_RS03490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
YSA_RS03500	COG0840	transmembrane signaling receptor activity
YSA_RS03530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YSA_RS03540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YSA_RS03545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YSA_RS03550	COG0740	serine-type endopeptidase activity
YSA_RS03555	COG0544	peptidyl-prolyl cis-trans isomerase activity
YSA_RS03585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
YSA_RS03600	COG0395	ABC-type sugar transport system, permease component
YSA_RS03610	COG3842	ATPase activity
YSA_RS03615	COG3842	ATPase activity
YSA_RS03620	COG3284	Transcriptional regulator
YSA_RS03630	COG0840	transmembrane signaling receptor activity
YSA_RS03645	COG2186	Transcriptional regulator
YSA_RS03665	COG0583	DNA-binding transcription factor activity
YSA_RS03670	COG0840	transmembrane signaling receptor activity
YSA_RS03675	COG3949	Membrane
YSA_RS03680	COG0251	oxidation-reduction process
YSA_RS03695	COG0730	response to heat
YSA_RS03780	COG1335	isochorismatase
YSA_RS03795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YSA_RS03795	COG2111	Na H antiporter
YSA_RS03800	COG1006	Multisubunit Na H antiporter MnhC subunit
YSA_RS03805	COG0651	ATP synthesis coupled electron transport
YSA_RS03815	COG2212	antiporter activity
YSA_RS03820	COG1320	monovalent cation:proton antiporter activity
YSA_RS03850	COG1024	Enoyl-CoA hydratase
YSA_RS03855	COG1960	acyl-CoA dehydrogenase activity
YSA_RS03860	COG0183	Belongs to the thiolase family
YSA_RS03870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YSA_RS03880	COG2207	Transcriptional regulator
YSA_RS03885	COG0583	DNA-binding transcription factor activity
YSA_RS03890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YSA_RS03895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YSA_RS03910	COG0826	peptidase U32
YSA_RS03925	COG1238	metal cluster binding
YSA_RS03930	COG0596	Alpha beta hydrolase
YSA_RS03940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YSA_RS03945	COG2133	pyrroloquinoline quinone binding
YSA_RS03955	COG0010	Belongs to the arginase family
YSA_RS03975	COG1595	DNA-templated transcription, initiation
YSA_RS04000	COG0589	response to stress
YSA_RS04010	COG3383	formate dehydrogenase (NAD+) activity
YSA_RS04040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YSA_RS04045	COG0174	glutamine synthetase
YSA_RS04055	COG0583	DNA-binding transcription factor activity
YSA_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS04105	COG3328	transposase activity
YSA_RS04115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YSA_RS04120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YSA_RS04135	COG4566	intracellular signal transduction
YSA_RS04145	COG2853	Lipoprotein
YSA_RS04160	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
YSA_RS04160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
YSA_RS04180	COG4591	ABC-type transport system involved in lipoprotein release permease component
YSA_RS04185	COG1136	(ABC) transporter
YSA_RS04190	COG4591	ABC-type transport system involved in lipoprotein release permease component
YSA_RS04200	COG0584	glycerophosphoryl diester phosphodiesterase
YSA_RS04205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YSA_RS04210	COG1477	protein flavinylation
YSA_RS04220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YSA_RS04230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YSA_RS04245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YSA_RS04275	COG0183	Belongs to the thiolase family
YSA_RS04280	COG1250	3-hydroxyacyl-CoA dehydrogenase
YSA_RS04280	COG1024	Enoyl-CoA hydratase
YSA_RS04290	COG0589	response to stress
YSA_RS04295	COG0488	(ABC) transporter
YSA_RS04300	COG0741	lytic transglycosylase activity
YSA_RS04310	COG0633	Ferredoxin
YSA_RS04310	COG3217	Mosc domain protein beta barrel domain protein
YSA_RS04315	COG0784	Response regulator, receiver
YSA_RS04315	COG0835	chemotaxis
YSA_RS04325	COG3851	Histidine kinase
YSA_RS04330	COG2197	response regulator
YSA_RS04335	COG1597	lipid kinase activity
YSA_RS04340	COG0438	transferase activity, transferring glycosyl groups
YSA_RS04350	COG0521	Mo-molybdopterin cofactor biosynthetic process
YSA_RS04370	COG1132	(ABC) transporter
YSA_RS04375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YSA_RS04380	COG0425	Belongs to the sulfur carrier protein TusA family
YSA_RS04390	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
YSA_RS04400	COG0840	transmembrane signaling receptor activity
YSA_RS04425	COG0004	ammonium transporteR
YSA_RS04450	COG2197	response regulator
YSA_RS04455	COG2205	protein histidine kinase activity
YSA_RS04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS04460	COG3171	Protein conserved in bacteria
YSA_RS04465	COG2027	D-alanyl-D-alanine carboxypeptidase
YSA_RS04475	COG0116	Belongs to the methyltransferase superfamily
YSA_RS04475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YSA_RS04480	COG3130	regulation of translation
YSA_RS04485	COG0167	dihydroorotate dehydrogenase activity
YSA_RS04490	COG1116	anion transmembrane transporter activity
YSA_RS04490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YSA_RS04495	COG3707	response regulator
YSA_RS04500	COG2223	nitrite transmembrane transporter activity
YSA_RS04525	COG0668	transmembrane transport
YSA_RS04540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YSA_RS04555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
YSA_RS04570	COG0583	DNA-binding transcription factor activity
YSA_RS04575	COG0019	diaminopimelate decarboxylase activity
YSA_RS04580	COG1595	DNA-templated transcription, initiation
YSA_RS04650	COG2188	Transcriptional regulator
YSA_RS04655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YSA_RS04665	COG0789	Transcriptional regulator
YSA_RS04670	COG3237	CsbD-like
YSA_RS04680	COG2851	Citrate transporter
YSA_RS04685	COG1301	dicarboxylic acid transport
YSA_RS04690	COG2828	Protein conserved in bacteria
YSA_RS04695	COG0583	DNA-binding transcription factor activity
YSA_RS04710	COG0246	Mannitol dehydrogenase
YSA_RS04715	COG0183	Belongs to the thiolase family
YSA_RS04725	COG1454	alcohol dehydrogenase
YSA_RS04730	COG1960	acyl-CoA dehydrogenase activity
YSA_RS04735	COG1250	3-hydroxyacyl-CoA dehydrogenase
YSA_RS04735	COG1024	Enoyl-CoA hydratase
YSA_RS04740	COG0583	DNA-binding transcription factor activity
YSA_RS04745	COG2015	COG2015, Alkyl sulfatase and related hydrolases
YSA_RS04755	COG2149	membrane
YSA_RS04780	COG1960	acyl-CoA dehydrogenase activity
YSA_RS04785	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS04795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YSA_RS04800	COG3135	benzoate transporter
YSA_RS04815	COG0714	Associated with various cellular activities
YSA_RS04850	COG0420	3'-5' exonuclease activity
YSA_RS04865	COG2706	6-phosphogluconolactonase activity
YSA_RS04885	COG0308	aminopeptidase N
YSA_RS04895	COG3139	Protein of unknown function (DUF1315)
YSA_RS04900	COG0705	Rhomboid family
YSA_RS04905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YSA_RS04910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YSA_RS04920	COG3038	cytochrome b561
YSA_RS04930	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS04930	COG0446	pyridine nucleotide-disulphide oxidoreductase
YSA_RS04935	COG2207	Transcriptional regulator
YSA_RS04945	COG0604	alcohol dehydrogenase
YSA_RS04950	COG4221	oxidoreductase activity
YSA_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS05000	COG2205	protein histidine kinase activity
YSA_RS05000	COG0784	Response regulator, receiver
YSA_RS05005	COG2202	Pas domain
YSA_RS05005	COG2199	diguanylate cyclase activity
YSA_RS05005	COG2200	EAL domain
YSA_RS05010	COG2205	protein histidine kinase activity
YSA_RS05010	COG0784	Response regulator, receiver
YSA_RS05015	COG2197	response regulator
YSA_RS05090	COG1286	toxin biosynthetic process
YSA_RS05100	COG0285	dihydrofolate synthase activity
YSA_RS05105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
YSA_RS05110	COG0135	phosphoribosylanthranilate isomerase activity
YSA_RS05145	COG0473	3-isopropylmalate dehydrogenase activity
YSA_RS05150	COG2226	methyltransferase
YSA_RS05155	COG0066	3-isopropylmalate dehydratase activity
YSA_RS05160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YSA_RS05180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YSA_RS05190	COG0596	Alpha beta hydrolase
YSA_RS05230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YSA_RS05245	COG0556	nucleotide-excision repair
YSA_RS05300	COG0084	hydrolase, TatD family'
YSA_RS05310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YSA_RS05315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YSA_RS05325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YSA_RS05330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YSA_RS05345	COG0416	fatty acid biosynthetic process
YSA_RS05350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YSA_RS05360	COG0424	maF-like protein
YSA_RS05365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YSA_RS05365	COG0616	signal peptide processing
YSA_RS05370	COG0546	phosphoglycolate phosphatase activity
YSA_RS05385	COG1530	ribonuclease E activity
YSA_RS05390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YSA_RS05395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YSA_RS05400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
YSA_RS05405	COG2835	tetraacyldisaccharide 4'-kinase activity
YSA_RS05410	COG1663	tetraacyldisaccharide 4'-kinase activity
YSA_RS05415	COG0848	biopolymer transport protein
YSA_RS05420	COG0811	peptide transport
YSA_RS05435	COG0842	Transport permease protein
YSA_RS05440	COG1131	(ABC) transporter
YSA_RS05445	COG0625	glutathione transferase activity
YSA_RS05465	COG3121	Chaperone
YSA_RS05515	COG3188	usher protein
YSA_RS05560	COG1956	GAF domain-containing protein
YSA_RS05570	COG5002	protein histidine kinase activity
YSA_RS05570	COG2205	protein histidine kinase activity
YSA_RS05570	COG0784	Response regulator, receiver
YSA_RS05575	COG0386	Belongs to the glutathione peroxidase family
YSA_RS05580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YSA_RS05585	COG0436	Aminotransferase
YSA_RS05595	COG0501	Belongs to the peptidase M48B family
YSA_RS05600	COG0500	methyltransferase
YSA_RS05605	COG3384	dioxygenase
YSA_RS05620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
YSA_RS05640	COG0583	DNA-binding transcription factor activity
YSA_RS05650	COG0583	DNA-binding transcription factor activity
YSA_RS05655	COG1846	Transcriptional regulator
YSA_RS05660	COG1764	response to oxidative stress
YSA_RS05665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YSA_RS05685	COG0583	DNA-binding transcription factor activity
YSA_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS05695	COG0583	DNA-binding transcription factor activity
YSA_RS05700	COG2814	Major facilitator Superfamily
YSA_RS05715	COG4773	Receptor
YSA_RS05735	COG0598	Magnesium transport protein CorA
YSA_RS05740	COG0519	Catalyzes the synthesis of GMP from XMP
YSA_RS05760	COG1368	sulfuric ester hydrolase activity
YSA_RS05800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
YSA_RS05805	COG2814	Major facilitator Superfamily
YSA_RS05810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YSA_RS05840	COG2840	Smr protein MutS2
YSA_RS05845	COG0302	gtp cyclohydrolase
YSA_RS05860	COG0625	glutathione transferase activity
YSA_RS05865	COG3135	benzoate transporter
YSA_RS05870	COG0840	transmembrane signaling receptor activity
YSA_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS05885	COG2130	NADP-dependent
YSA_RS05895	COG0284	orotidine-5'-phosphate decarboxylase activity
YSA_RS05905	COG1555	photosystem II stabilization
YSA_RS05935	COG0166	Belongs to the GPI family
YSA_RS05940	COG2877	3-deoxy-8-phosphooctulonate synthase activity
YSA_RS05945	COG0517	IMP dehydrogenase activity
YSA_RS05945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YSA_RS05955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YSA_RS05985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
YSA_RS05995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS06020	COG1216	Glycosyl transferase, family 2
YSA_RS06020	COG0438	transferase activity, transferring glycosyl groups
YSA_RS06030	COG0438	transferase activity, transferring glycosyl groups
YSA_RS06035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YSA_RS06070	COG0438	transferase activity, transferring glycosyl groups
YSA_RS06090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YSA_RS06095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
YSA_RS06095	COG0662	Cupin 2, conserved barrel domain protein
YSA_RS06100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YSA_RS06100	COG2755	lipolytic protein G-D-S-L family
YSA_RS06105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YSA_RS06115	COG0776	regulation of translation
YSA_RS06130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YSA_RS06135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
YSA_RS06145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
YSA_RS06160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YSA_RS06165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YSA_RS06170	COG0546	phosphoglycolate phosphatase activity
YSA_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS06185	COG5002	protein histidine kinase activity
YSA_RS06185	COG5001	Diguanylate cyclase
YSA_RS06200	COG1054	Belongs to the UPF0176 family
YSA_RS06205	COG0271	Belongs to the BolA IbaG family
YSA_RS06215	COG0114	fumarate hydratase activity
YSA_RS06220	COG0697	spore germination
YSA_RS06225	COG2326	polyphosphate kinase activity
YSA_RS06230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS06230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
YSA_RS06235	COG0367	asparagine synthase
YSA_RS06240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YSA_RS06240	COG0189	ligase activity
YSA_RS06245	COG1363	Peptidase, m42
YSA_RS06250	COG3089	Belongs to the UPF0270 family
YSA_RS06260	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS06295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YSA_RS06300	COG3162	membrane
YSA_RS06305	COG2113	Glycine betaine
YSA_RS06325	COG2853	Lipoprotein
YSA_RS06335	COG1560	Kdo2-lipid A biosynthetic process
YSA_RS06340	COG0850	regulation of cytokinetic process
YSA_RS06345	COG2894	cell division
YSA_RS06350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YSA_RS06355	COG0564	pseudouridine synthase activity
YSA_RS06360	COG1362	aminopeptidase activity
YSA_RS06365	COG0668	transmembrane transport
YSA_RS06385	COG1176	ABC-type spermidine putrescine transport system, permease component I
YSA_RS06415	COG3300	MHYT domain
YSA_RS06415	COG5001	Diguanylate cyclase
YSA_RS06430	COG3339	Conserved Protein
YSA_RS06435	COG0545	Peptidyl-prolyl cis-trans isomerase
YSA_RS06440	COG0583	DNA-binding transcription factor activity
YSA_RS06455	COG2169	Transcriptional regulator
YSA_RS06460	COG2271	Major facilitator Superfamily
YSA_RS06465	COG0179	Fumarylacetoacetate (FAA) hydrolase
YSA_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS06475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YSA_RS06485	COG2146	nitrite reductase [NAD(P)H] activity
YSA_RS06485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YSA_RS06490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YSA_RS06490	COG2146	nitrite reductase [NAD(P)H] activity
YSA_RS06495	COG0243	molybdopterin cofactor binding
YSA_RS06505	COG0024	Methionine aminopeptidase
YSA_RS06530	COG2974	May be involved in recombination
YSA_RS06535	COG2076	Multidrug Resistance protein
YSA_RS06540	COG0477	Major facilitator Superfamily
YSA_RS06550	COG2814	Major facilitator Superfamily
YSA_RS06555	COG2188	Transcriptional regulator
YSA_RS06560	COG2814	Major facilitator Superfamily
YSA_RS06565	COG2205	protein histidine kinase activity
YSA_RS06595	COG0583	DNA-binding transcription factor activity
YSA_RS06615	COG1846	Transcriptional regulator
YSA_RS06625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
YSA_RS06630	COG0406	alpha-ribazole phosphatase activity
YSA_RS06635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
YSA_RS06645	COG1492	cobalamin metabolic process
YSA_RS06655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YSA_RS06660	COG0778	Nitroreductase
YSA_RS06665	COG1797	cobyrinic acid a,c-diamide synthase activity
YSA_RS06675	COG0791	NLP P60 protein
YSA_RS06680	COG0791	NLP P60 protein
YSA_RS06690	COG0628	permease
YSA_RS06705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YSA_RS06710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YSA_RS06745	COG3122	Protein conserved in bacteria
YSA_RS06750	COG3956	TIGRFAM MazG family protein
YSA_RS06755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YSA_RS06765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YSA_RS06785	COG5002	protein histidine kinase activity
YSA_RS06785	COG2205	protein histidine kinase activity
YSA_RS06785	COG0784	Response regulator, receiver
YSA_RS06790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YSA_RS06835	COG0037	tRNA processing
YSA_RS06845	COG3091	SprT-like family
YSA_RS06855	COG0583	DNA-binding transcription factor activity
YSA_RS06870	COG3148	PFAM DTW domain containing protein
YSA_RS06895	COG2137	regulation of response to DNA damage stimulus
YSA_RS06900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YSA_RS06905	COG1546	Belongs to the CinA family
YSA_RS06915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
YSA_RS06920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
YSA_RS06935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YSA_RS06940	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
YSA_RS06945	COG0585	pseudouridine synthase activity
YSA_RS06950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
YSA_RS06960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
YSA_RS06970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YSA_RS06980	COG0148	phosphopyruvate hydratase activity
YSA_RS06985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
YSA_RS06990	COG0504	CTP synthase activity
YSA_RS06995	COG0037	tRNA processing
YSA_RS07000	COG0825	malonyl-CoA metabolic process
YSA_RS07010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
YSA_RS07015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YSA_RS07020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YSA_RS07025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YSA_RS07030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YSA_RS07050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
YSA_RS07060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YSA_RS07065	COG0233	cytoplasmic translational termination
YSA_RS07070	COG0528	UMP kinase activity
YSA_RS07075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YSA_RS07080	COG0052	Belongs to the universal ribosomal protein uS2 family
YSA_RS07085	COG0024	Methionine aminopeptidase
YSA_RS07090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
YSA_RS07095	COG0436	Aminotransferase
YSA_RS07105	COG0025	NhaP-type Na H and K H
YSA_RS07120	COG1393	Belongs to the ArsC family
YSA_RS07125	COG2171	N-acyltransferase activity
YSA_RS07130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YSA_RS07140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YSA_RS07145	COG1215	transferase activity, transferring glycosyl groups
YSA_RS07150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YSA_RS07155	COG2226	methyltransferase
YSA_RS07170	COG2937	Belongs to the GPAT DAPAT family
YSA_RS07190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS07200	COG0742	ribosomal rna small subunit methyltransferase
YSA_RS07235	COG0563	adenylate kinase activity
YSA_RS07240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
YSA_RS07260	COG2885	chlorophyll binding
YSA_RS07270	COG1073	alpha beta
YSA_RS07290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YSA_RS07300	COG5001	Diguanylate cyclase
YSA_RS07300	COG4251	negative regulation of phosphorylation
YSA_RS07300	COG2203	Gaf domain
YSA_RS07300	COG3706	GGDEF domain
YSA_RS07305	COG2201	protein-glutamate methylesterase activity
YSA_RS07320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YSA_RS07320	COG0457	Tetratricopeptide repeat
YSA_RS07330	COG0840	transmembrane signaling receptor activity
YSA_RS07335	COG2979	Protein of unknown function (DUF533)
YSA_RS07340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YSA_RS07345	COG3842	ATPase activity
YSA_RS07350	COG1176	ABC-type spermidine putrescine transport system, permease component I
YSA_RS07355	COG1177	transmembrane transport
YSA_RS07360	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS07375	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS07390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YSA_RS07425	COG4974	Belongs to the 'phage' integrase family
YSA_RS07435	COG1607	acyl-coa hydrolase
YSA_RS07440	COG0335	large ribosomal subunit rRNA binding
YSA_RS07445	COG0336	Belongs to the RNA methyltransferase TrmD family
YSA_RS07450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
YSA_RS07455	COG0228	four-way junction DNA binding
YSA_RS07460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YSA_RS07470	COG4536	flavin adenine dinucleotide binding
YSA_RS07475	COG0477	Major facilitator Superfamily
YSA_RS07480	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
YSA_RS07500	COG0494	nUDIX hydrolase
YSA_RS07530	COG4628	conserved protein (DUF2132)
YSA_RS07535	COG4206	TonB-dependent receptor
YSA_RS07550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YSA_RS07560	COG2226	methyltransferase
YSA_RS07565	COG0500	methyltransferase
YSA_RS07585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YSA_RS07590	COG1381	Involved in DNA repair and RecF pathway recombination
YSA_RS07595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YSA_RS07600	COG0571	ribonuclease III activity
YSA_RS07605	COG0681	Belongs to the peptidase S26 family
YSA_RS07610	COG0481	GTPase activity
YSA_RS07615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YSA_RS07645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
YSA_RS07650	COG0354	folic acid binding
YSA_RS07690	COG3180	Ammonia monooxygenase
YSA_RS07700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YSA_RS07730	COG2267	carboxylic ester hydrolase activity
YSA_RS07765	COG4191	Histidine kinase
YSA_RS07775	COG0477	Major facilitator Superfamily
YSA_RS07805	COG2207	Transcriptional regulator
YSA_RS07815	COG0583	DNA-binding transcription factor activity
YSA_RS07820	COG2910	NAD(P)H-binding
YSA_RS07830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
YSA_RS07835	COG0477	Major facilitator Superfamily
YSA_RS07840	COG1309	transcriptional regulator
YSA_RS07845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS07870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YSA_RS07875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YSA_RS07880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YSA_RS07885	COG0477	Major facilitator Superfamily
YSA_RS07890	COG0183	Belongs to the thiolase family
YSA_RS07895	COG2814	Major facilitator Superfamily
YSA_RS07900	COG1414	Transcriptional regulator
YSA_RS07915	COG0306	phosphate transporter
YSA_RS07920	COG0433	COG0433 Predicted ATPase
YSA_RS07925	COG0840	transmembrane signaling receptor activity
YSA_RS07930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YSA_RS07930	COG0438	transferase activity, transferring glycosyl groups
YSA_RS07950	COG0788	formyltetrahydrofolate deformylase activity
YSA_RS07960	COG2925	Exonuclease
YSA_RS07980	COG0459	protein refolding
YSA_RS07985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
YSA_RS07990	COG3030	protein affecting phage T7 exclusion by the F plasmid
YSA_RS08025	COG0668	transmembrane transport
YSA_RS08030	COG1666	GTP binding
YSA_RS08045	COG2096	Adenosyltransferase
YSA_RS08055	COG0494	nUDIX hydrolase
YSA_RS08065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
YSA_RS08070	COG0653	protein targeting
YSA_RS08085	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
YSA_RS08090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YSA_RS08105	COG1181	Belongs to the D-alanine--D-alanine ligase family
YSA_RS08110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YSA_RS08115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YSA_RS08120	COG0772	Belongs to the SEDS family
YSA_RS08125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
YSA_RS08130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YSA_RS08135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YSA_RS08140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YSA_RS08155	COG0275	rRNA processing
YSA_RS08160	COG2001	Belongs to the MraZ family
YSA_RS08180	COG0792	nuclease activity
YSA_RS08185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YSA_RS08190	COG2823	Periplasmic or secreted lipoprotein
YSA_RS08195	COG2969	positive regulation of protein catabolic process
YSA_RS08200	COG0625	glutathione transferase activity
YSA_RS08205	COG2857	Cytochrome c1
YSA_RS08210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
YSA_RS08215	COG0723	plastoquinol--plastocyanin reductase activity
YSA_RS08220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
YSA_RS08225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YSA_RS08230	COG0667	Aldo Keto reductase
YSA_RS08240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YSA_RS08245	COG0180	Tryptophanyl-tRNA synthetase
YSA_RS08265	COG1522	sequence-specific DNA binding
YSA_RS08285	COG0175	sulfate reduction
YSA_RS08295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YSA_RS08300	COG1126	abc transporter atp-binding protein
YSA_RS08305	COG0765	amino acid transport
YSA_RS08310	COG4597	amino acid ABC transporter
YSA_RS08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS08320	COG0400	carboxylic ester hydrolase activity
YSA_RS08325	COG0513	Belongs to the DEAD box helicase family
YSA_RS08340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YSA_RS08345	COG0315	cyclic pyranopterin monophosphate synthase activity
YSA_RS08350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
YSA_RS08360	COG3022	response to hydroperoxide
YSA_RS08365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
YSA_RS08370	COG1215	transferase activity, transferring glycosyl groups
YSA_RS08375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS08380	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
YSA_RS08390	COG3420	alginic acid biosynthetic process
YSA_RS08410	COG1696	Membrane protein involved in D-alanine export
YSA_RS08425	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
YSA_RS08425	COG0662	Cupin 2, conserved barrel domain protein
YSA_RS08440	COG0300	oxidoreductase activity
YSA_RS08470	COG1566	PFAM secretion protein HlyD family protein
YSA_RS08490	COG0583	DNA-binding transcription factor activity
YSA_RS08495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YSA_RS08500	COG0697	spore germination
YSA_RS08505	COG2207	Transcriptional regulator
YSA_RS08505	COG3708	Transcriptional regulator
YSA_RS08585	COG0179	Fumarylacetoacetate (FAA) hydrolase
YSA_RS08590	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
YSA_RS08610	COG1346	cytolysis
YSA_RS08620	COG0583	DNA-binding transcription factor activity
YSA_RS08630	COG1366	Belongs to the anti-sigma-factor antagonist family
YSA_RS08675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
YSA_RS08685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YSA_RS08695	COG0523	cobalamin synthesis protein
YSA_RS08700	COG2879	small protein
YSA_RS08705	COG1966	Carbon starvation protein
YSA_RS08715	COG2233	PERMEase
YSA_RS08725	COG1970	mechanosensitive ion channel activity
YSA_RS08740	COG2197	response regulator
YSA_RS08745	COG2813	Specifically methylates the guanine in position
YSA_RS08755	COG1294	oxidase, subunit
YSA_RS08760	COG1271	oxidase subunit
YSA_RS08770	COG2252	PERMEase
YSA_RS08775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YSA_RS08780	COG3485	protocatechuate 3,4-dioxygenase
YSA_RS08785	COG3485	protocatechuate 3,4-dioxygenase
YSA_RS08790	COG2321	neutral zinc metallopeptidase
YSA_RS08795	COG0840	transmembrane signaling receptor activity
YSA_RS08805	COG0583	DNA-binding transcription factor activity
YSA_RS08815	COG2249	NAD(P)H dehydrogenase (quinone) activity
YSA_RS08865	COG2885	chlorophyll binding
YSA_RS08865	COG3047	cAMP biosynthetic process
YSA_RS08870	COG2199	diguanylate cyclase activity
YSA_RS08880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YSA_RS08885	COG1074	ATP-dependent DNA helicase activity
YSA_RS08890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YSA_RS08920	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
YSA_RS08925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YSA_RS08930	COG1183	phosphatidylcholine synthase activity
YSA_RS08935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YSA_RS08945	COG0028	Belongs to the TPP enzyme family
YSA_RS08950	COG3098	single-species biofilm formation
YSA_RS08960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YSA_RS08980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YSA_RS08985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YSA_RS08990	COG4558	Periplasmic binding protein
YSA_RS09000	COG1489	DNA binding
YSA_RS09005	COG0436	Aminotransferase
YSA_RS09015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YSA_RS09025	COG4191	Histidine kinase
YSA_RS09045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YSA_RS09050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YSA_RS09055	COG0166	Belongs to the GPI family
YSA_RS09065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YSA_RS09090	COG2823	Periplasmic or secreted lipoprotein
YSA_RS09095	COG1185	polyribonucleotide nucleotidyltransferase activity
YSA_RS09105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
YSA_RS09110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YSA_RS09115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
YSA_RS09120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YSA_RS09125	COG0195	Participates in both transcription termination and antitermination
YSA_RS09130	COG0779	Required for maturation of 30S ribosomal subunits
YSA_RS09145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YSA_RS09150	COG0149	triose-phosphate isomerase activity
YSA_RS09155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YSA_RS09160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YSA_RS09170	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
YSA_RS09185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YSA_RS09190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YSA_RS09195	COG0505	Belongs to the CarA family
YSA_RS09200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
YSA_RS09205	COG0484	heat shock protein binding
YSA_RS09210	COG0443	Heat shock 70 kDa protein
YSA_RS09215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YSA_RS09220	COG0497	DNA recombination
YSA_RS09225	COG0735	belongs to the Fur family
YSA_RS09230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YSA_RS09240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YSA_RS09245	COG2186	Transcriptional regulator
YSA_RS09250	COG1620	l-lactate permease
YSA_RS09255	COG1304	FMN binding
YSA_RS09275	COG0582	viral genome integration into host DNA
YSA_RS09335	COG0789	Transcriptional regulator
YSA_RS09345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
YSA_RS09355	COG0626	cystathionine gamma-synthase activity
YSA_RS09365	COG1280	lysine exporter protein (LysE YggA)
YSA_RS09370	COG3039	Transposase
YSA_RS09380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
YSA_RS09440	COG0840	transmembrane signaling receptor activity
YSA_RS09450	COG0582	viral genome integration into host DNA
YSA_RS09460	COG4983	Phage plasmid primase, P4 family domain protein
YSA_RS09505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YSA_RS09530	COG1401	restriction endodeoxyribonuclease activity
YSA_RS09555	COG4774	siderophore transport
YSA_RS09585	COG2271	Major facilitator Superfamily
YSA_RS09590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YSA_RS09595	COG0583	DNA-binding transcription factor activity
YSA_RS09620	COG3321	synthase
YSA_RS09620	COG0604	alcohol dehydrogenase
YSA_RS09625	COG0546	phosphoglycolate phosphatase activity
YSA_RS09630	COG1946	Acyl-CoA thioesterase
YSA_RS09640	COG0406	alpha-ribazole phosphatase activity
YSA_RS09645	COG0123	including yeast histone deacetylase and acetoin utilization protein
YSA_RS09655	COG0513	Belongs to the DEAD box helicase family
YSA_RS09660	COG0697	spore germination
YSA_RS09665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YSA_RS09675	COG3416	Protein conserved in bacteria
YSA_RS09690	COG1643	Atp-dependent helicase
YSA_RS09710	COG1522	sequence-specific DNA binding
YSA_RS09730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YSA_RS09735	COG1960	acyl-CoA dehydrogenase activity
YSA_RS09740	COG4999	Histidine kinase
YSA_RS09740	COG3850	Histidine kinase
YSA_RS09740	COG3437	response regulator, receiver
YSA_RS09740	COG2205	protein histidine kinase activity
YSA_RS09745	COG0351	phosphomethylpyrimidine kinase
YSA_RS09750	COG0352	thiamine-phosphate diphosphorylase activity
YSA_RS09755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YSA_RS09770	COG1702	phosphate starvation-inducible protein PhoH
YSA_RS09775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
YSA_RS09780	COG4535	Mg2 and Co2 transporter CorC
YSA_RS09785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YSA_RS09805	COG0495	leucyl-tRNA aminoacylation
YSA_RS09825	COG2951	lytic endotransglycosylase activity
YSA_RS09830	COG1619	proteins homologs of microcin C7 resistance protein MccF
YSA_RS09835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YSA_RS09840	COG0321	lipoyl(octanoyl) transferase activity
YSA_RS09845	COG2921	Belongs to the UPF0250 family
YSA_RS09850	COG1686	Belongs to the peptidase S11 family
YSA_RS09860	COG2951	lytic endotransglycosylase activity
YSA_RS09865	COG0772	Belongs to the SEDS family
YSA_RS09870	COG0768	penicillin binding
YSA_RS09875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
YSA_RS09885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YSA_RS09890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YSA_RS09900	COG2094	Belongs to the DNA glycosylase MPG family
YSA_RS09905	COG0586	Pfam SNARE associated Golgi protein
YSA_RS09915	COG1346	cytolysis
YSA_RS09930	COG2264	protein methyltransferase activity
YSA_RS09940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YSA_RS09950	COG0138	bifunctional purine biosynthesis protein purh
YSA_RS09955	COG0151	Belongs to the GarS family
YSA_RS09965	COG2095	MarC family integral membrane protein
YSA_RS10000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YSA_RS10010	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
YSA_RS10025	COG0330	HflC and HflK could
YSA_RS10045	COG4774	siderophore transport
YSA_RS10055	COG1113	amino acid transport
YSA_RS10075	COG0411	ABC transporter
YSA_RS10090	COG0789	Transcriptional regulator
YSA_RS10095	COG0484	heat shock protein binding
YSA_RS10100	COG0443	Heat shock 70 kDa protein
YSA_RS10120	COG0697	spore germination
YSA_RS10140	COG2982	Protein involved in outer membrane biogenesis
YSA_RS10170	COG4221	oxidoreductase activity
YSA_RS10200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
YSA_RS10205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YSA_RS10220	COG1032	radical SAM domain protein
YSA_RS10225	COG0305	Participates in initiation and elongation during chromosome replication
YSA_RS10230	COG0359	binds to the 23S rRNA
YSA_RS10240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YSA_RS10245	COG0360	Binds together with S18 to 16S ribosomal RNA
YSA_RS10250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YSA_RS10270	COG1840	ABC-type Fe3 transport system, periplasmic component
YSA_RS10275	COG1178	ABC-type Fe3 transport system permease component
YSA_RS10285	COG0840	transmembrane signaling receptor activity
YSA_RS10290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YSA_RS10295	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
YSA_RS10300	COG0330	HflC and HflK could
YSA_RS10305	COG0330	HflC and HflK could
YSA_RS10310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YSA_RS10315	COG1923	regulation of RNA biosynthetic process
YSA_RS10320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YSA_RS10325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YSA_RS10330	COG0860	N-Acetylmuramoyl-L-alanine amidase
YSA_RS10335	COG0802	atpase or kinase
YSA_RS10340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YSA_RS10340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YSA_RS10350	COG2860	membrane
YSA_RS10355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YSA_RS10360	COG1162	GTPase activity
YSA_RS10370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YSA_RS10385	COG0688	phosphatidylethanolamine metabolic process
YSA_RS10390	COG0560	Phosphoserine phosphatase
YSA_RS10390	COG3830	Belongs to the UPF0237 family
YSA_RS10415	COG3577	Aspartyl protease
YSA_RS10430	COG3150	esterase
YSA_RS10435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YSA_RS10445	COG0494	nUDIX hydrolase
YSA_RS10460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YSA_RS10465	COG1538	Outer membrane efflux protein
YSA_RS10470	COG1519	Transferase
YSA_RS10475	COG0583	DNA-binding transcription factor activity
YSA_RS10490	COG0667	Aldo Keto reductase
YSA_RS10500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
YSA_RS10500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
YSA_RS10505	COG1132	(ABC) transporter
YSA_RS10520	COG0438	transferase activity, transferring glycosyl groups
YSA_RS10545	COG0438	transferase activity, transferring glycosyl groups
YSA_RS10550	COG2192	nodulation
YSA_RS10555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YSA_RS10560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YSA_RS10565	COG0506	proline dehydrogenase activity
YSA_RS10565	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YSA_RS10565	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YSA_RS10580	COG1960	acyl-CoA dehydrogenase activity
YSA_RS10590	COG0312	modulator of DNA gyrase
YSA_RS10595	COG0477	Major facilitator Superfamily
YSA_RS10600	COG0513	Belongs to the DEAD box helicase family
YSA_RS10605	COG2081	HI0933 family
YSA_RS10610	COG1289	transmembrane transporter activity
YSA_RS10615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS10620	COG2153	protein acetylation
YSA_RS10630	COG1451	nucleotide metabolic process
YSA_RS10635	COG5001	Diguanylate cyclase
YSA_RS10635	COG3300	MHYT domain
YSA_RS10655	COG0126	phosphoglycerate kinase activity
YSA_RS10660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YSA_RS10665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YSA_RS10670	COG0640	Transcriptional regulator
YSA_RS10675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YSA_RS10680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YSA_RS10725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
YSA_RS10730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
YSA_RS10750	COG0513	Belongs to the DEAD box helicase family
YSA_RS10755	COG2353	YceI-like domain
YSA_RS10760	COG3038	cytochrome b561
YSA_RS10780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YSA_RS10785	COG1272	protein, Hemolysin III
YSA_RS10795	COG2198	Histidine kinase
YSA_RS10795	COG0643	Histidine kinase
YSA_RS10795	COG0784	Response regulator, receiver
YSA_RS10820	COG0189	ligase activity
YSA_RS10830	COG1678	Uncharacterized ACR, COG1678
YSA_RS10835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
YSA_RS10840	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
YSA_RS10845	COG0540	Belongs to the ATCase OTCase family
YSA_RS10850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YSA_RS10855	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
YSA_RS10860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
YSA_RS10910	COG2226	methyltransferase
YSA_RS10920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YSA_RS10925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YSA_RS10930	COG0140	phosphoribosyl-ATP diphosphatase activity
YSA_RS10935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YSA_RS10955	COG0840	transmembrane signaling receptor activity
YSA_RS10960	COG0840	transmembrane signaling receptor activity
YSA_RS10965	COG1126	abc transporter atp-binding protein
YSA_RS10970	COG0765	amino acid transport
YSA_RS10980	COG2943	transferase activity, transferring hexosyl groups
YSA_RS10985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
YSA_RS10990	COG1490	D-aminoacyl-tRNA deacylase activity
YSA_RS11005	COG1228	amidohydrolase
YSA_RS11015	COG2986	histidine ammonia-lyase
YSA_RS11020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
YSA_RS11030	COG2188	Transcriptional regulator
YSA_RS11035	COG0402	S-adenosylhomocysteine deaminase activity
YSA_RS11060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YSA_RS11065	COG0058	SHG alpha-glucan phosphorylase activity
YSA_RS11080	COG1217	gtp-binding protein TYPA
YSA_RS11085	COG0301	tRNA thio-modification
YSA_RS11085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YSA_RS11100	COG3852	Histidine kinase
YSA_RS11115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YSA_RS11120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
YSA_RS11130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YSA_RS11135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YSA_RS11140	COG4942	peptidase
YSA_RS11145	COG0793	Belongs to the peptidase S41A family
YSA_RS11150	COG2861	carbohydrate metabolic process
YSA_RS11160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YSA_RS11165	COG1309	transcriptional regulator
YSA_RS11170	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS11175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YSA_RS11185	COG3263	regulation of cellular component size
YSA_RS11190	COG3264	Mechanosensitive ion channel
YSA_RS11190	COG1196	nuclear chromosome segregation
YSA_RS11195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
YSA_RS11205	COG3118	belongs to the thioredoxin family
YSA_RS11210	COG1192	Involved in chromosome partitioning
YSA_RS11215	COG0583	DNA-binding transcription factor activity
YSA_RS11220	COG2814	Major facilitator Superfamily
YSA_RS11290	COG3397	chitin binding
YSA_RS11295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
YSA_RS11300	COG0493	'glutamate synthase
YSA_RS11305	COG0070	glutamate synthase
YSA_RS11305	COG0069	glutamate synthase activity
YSA_RS11305	COG0067	glutamate synthase
YSA_RS11315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
YSA_RS11320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YSA_RS11350	COG0281	malic enzyme
YSA_RS11360	COG0254	rRNA binding
YSA_RS11365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YSA_RS11370	COG0018	arginyl-trna synthetase
YSA_RS11385	COG0791	NLP P60 protein
YSA_RS11415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YSA_RS11420	COG2813	Specifically methylates the guanine in position
YSA_RS11420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YSA_RS11430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YSA_RS11435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YSA_RS11445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
YSA_RS11450	COG2022	thiamine diphosphate biosynthetic process
YSA_RS11460	COG2363	Small membrane protein
YSA_RS11465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YSA_RS11475	COG2177	Part of the ABC transporter FtsEX involved in
YSA_RS11480	COG2884	Cell division ATP-binding protein ftsE
YSA_RS11485	COG0552	protein localization to endoplasmic reticulum
YSA_RS11495	COG0612	Peptidase, M16
YSA_RS11500	COG0612	Peptidase, M16
YSA_RS11505	COG0742	ribosomal rna small subunit methyltransferase
YSA_RS11515	COG0612	Peptidase, M16
YSA_RS11545	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YSA_RS11550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YSA_RS11555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YSA_RS11565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YSA_RS11575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YSA_RS11580	COG0129	dihydroxy-acid dehydratase activity
YSA_RS11605	COG1823	symporter activity
YSA_RS11620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YSA_RS11625	COG1840	ABC-type Fe3 transport system, periplasmic component
YSA_RS11630	COG1178	ABC-type Fe3 transport system permease component
YSA_RS11635	COG3842	ATPase activity
YSA_RS11645	COG0583	DNA-binding transcription factor activity
YSA_RS11655	COG0789	Transcriptional regulator
YSA_RS11660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
YSA_RS11665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YSA_RS11670	COG0730	response to heat
YSA_RS11680	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
YSA_RS11685	COG0494	nUDIX hydrolase
YSA_RS11700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YSA_RS11705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YSA_RS11710	COG3204	pilus organization
YSA_RS11715	COG3204	pilus organization
YSA_RS11725	COG0179	Fumarylacetoacetate (FAA) hydrolase
YSA_RS11730	COG0277	FAD linked oxidase domain protein
YSA_RS11735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YSA_RS11790	COG3829	transcription factor binding
YSA_RS11800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YSA_RS11805	COG4208	sulfate ABC transporter
YSA_RS11820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YSA_RS11830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YSA_RS11850	COG1177	transmembrane transport
YSA_RS11855	COG1176	ABC-type spermidine putrescine transport system, permease component I
YSA_RS11860	COG3842	ATPase activity
YSA_RS11880	COG0174	glutamine synthetase
YSA_RS11890	COG0174	glutamine synthetase
YSA_RS11895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YSA_RS11895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
YSA_RS11900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YSA_RS11910	COG1522	sequence-specific DNA binding
YSA_RS11930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YSA_RS11930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YSA_RS11935	COG0509	glycine decarboxylation via glycine cleavage system
YSA_RS11940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YSA_RS11945	COG1178	ABC-type Fe3 transport system permease component
YSA_RS11955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YSA_RS11965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YSA_RS11970	COG0006	proline dipeptidase activity
YSA_RS11975	COG3079	Belongs to the UPF0149 family
YSA_RS11995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YSA_RS12005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS12010	COG1129	ABC transporter
YSA_RS12010	COG0842	Transport permease protein
YSA_RS12015	COG0842	Transport permease protein
YSA_RS12040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
YSA_RS12055	COG0248	Ppx GppA phosphatase
YSA_RS12060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YSA_RS12075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YSA_RS12080	COG1671	Belongs to the UPF0178 family
YSA_RS12090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YSA_RS12100	COG1965	Belongs to the frataxin family
YSA_RS12110	COG0019	diaminopimelate decarboxylase activity
YSA_RS12115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YSA_RS12125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YSA_RS12130	COG0546	phosphoglycolate phosphatase activity
YSA_RS12145	COG0004	ammonium transporteR
YSA_RS12150	COG0347	Belongs to the P(II) protein family
YSA_RS12170	COG0606	chelatase, subunit chli
YSA_RS12180	COG4566	intracellular signal transduction
YSA_RS12185	COG4191	Histidine kinase
YSA_RS12190	COG1335	isochorismatase
YSA_RS12225	COG1335	isochorismatase
YSA_RS12230	COG0583	DNA-binding transcription factor activity
YSA_RS12265	COG1335	isochorismatase
YSA_RS12275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS12280	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS12285	COG0583	DNA-binding transcription factor activity
YSA_RS12290	COG5383	Protein conserved in bacteria
YSA_RS12300	COG0534	Mate efflux family protein
YSA_RS12315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YSA_RS12320	COG0427	acetyl-CoA hydrolase
YSA_RS12335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YSA_RS12345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS12370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS12375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YSA_RS12385	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS12400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YSA_RS12405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YSA_RS12410	COG0747	negative chemotaxis
YSA_RS12455	COG2963	transposase activity
YSA_RS12465	COG2433	Pfam Transposase IS66
YSA_RS12480	COG1288	antiporter activity
YSA_RS12495	COG2194	sulfuric ester hydrolase activity
YSA_RS12545	COG0463	Glycosyl transferase, family 2
YSA_RS12645	COG2003	Belongs to the UPF0758 family
YSA_RS12650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YSA_RS12655	COG0756	dUTP diphosphatase activity
YSA_RS12665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YSA_RS12670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YSA_RS12675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
YSA_RS12680	COG0708	Exodeoxyribonuclease III
YSA_RS12690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
YSA_RS12695	COG1561	YicC-like family, N-terminal region
YSA_RS12700	COG0194	GDP metabolic process
YSA_RS12710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YSA_RS12715	COG0174	glutamine synthetase
YSA_RS12725	COG1758	RNA polymerase activity
YSA_RS12730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YSA_RS12760	COG0848	biopolymer transport protein
YSA_RS12770	COG0583	DNA-binding transcription factor activity
YSA_RS12775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YSA_RS12810	COG3161	chorismate lyase activity
YSA_RS12815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
YSA_RS12835	COG1253	flavin adenine dinucleotide binding
YSA_RS12840	COG0739	heme binding
YSA_RS12850	COG0704	Plays a role in the regulation of phosphate uptake
YSA_RS12855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YSA_RS12860	COG0581	inorganic phosphate transmembrane transporter activity
YSA_RS12875	COG0477	Major facilitator Superfamily
YSA_RS12880	COG1607	acyl-coa hydrolase
YSA_RS12915	COG0583	DNA-binding transcription factor activity
YSA_RS12920	COG1027	Aspartate ammonia-lyase
YSA_RS12960	COG0511	ligase activity, forming carbon-carbon bonds
YSA_RS12960	COG5016	pyruvate
YSA_RS12965	COG0439	Biotin carboxylase
YSA_RS12970	COG0583	DNA-binding transcription factor activity
YSA_RS12985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YSA_RS12990	COG0210	DNA helicase
YSA_RS13005	COG4651	solute:proton antiporter activity
YSA_RS13005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YSA_RS13010	COG1607	acyl-coa hydrolase
YSA_RS13015	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
YSA_RS13025	COG0523	cobalamin synthesis protein
YSA_RS13050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YSA_RS13055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YSA_RS13060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YSA_RS13065	COG3958	Transketolase
YSA_RS13070	COG3959	Transketolase, thiamine diphosphate binding domain
YSA_RS13075	COG2271	Major facilitator Superfamily
YSA_RS13080	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS13085	COG0583	DNA-binding transcription factor activity
YSA_RS13140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YSA_RS13145	COG1349	DNA-binding transcription factor activity
YSA_RS13150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YSA_RS13155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YSA_RS13160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
YSA_RS13165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YSA_RS13170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
YSA_RS13175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
YSA_RS13180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YSA_RS13190	COG0356	it plays a direct role in the translocation of protons across the membrane
YSA_RS13195	COG3312	ion transport
YSA_RS13200	COG1475	DNA binding
YSA_RS13205	COG1192	Involved in chromosome partitioning
YSA_RS13210	COG0357	Ribosomal RNA small subunit methyltransferase G
YSA_RS13215	COG0445	tRNA wobble uridine modification
YSA_RS13220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YSA_RS13225	COG0706	membrane insertase activity
YSA_RS13230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
YSA_RS13235	COG0594	ribonuclease P activity
YSA_RS13240	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YSA_RS13245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YSA_RS13250	COG0592	DNA-directed DNA polymerase activity
YSA_RS13255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YSA_RS13260	COG0187	DNA topoisomerase II activity
YSA_RS13300	COG0477	Major facilitator Superfamily
YSA_RS13310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YSA_RS13315	COG0751	glycine-tRNA ligase activity
YSA_RS13320	COG0752	glycyl-tRNA synthetase alpha subunit
YSA_RS13325	COG2818	Glycosylase
YSA_RS13340	COG0569	domain protein
YSA_RS13345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YSA_RS13350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YSA_RS13355	COG0242	peptide deformylase activity
YSA_RS13360	COG0758	DNA mediated transformation
YSA_RS13365	COG0009	L-threonylcarbamoyladenylate synthase
YSA_RS13385	COG0408	coproporphyrinogen oxidase activity
YSA_RS13390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YSA_RS13395	COG0659	secondary active sulfate transmembrane transporter activity
YSA_RS13410	COG3119	arylsulfatase activity
YSA_RS13430	COG0159	tryptophan synthase activity
YSA_RS13435	COG0133	tryptophan synthase activity
YSA_RS13450	COG3360	Dodecin
YSA_RS13460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YSA_RS13465	COG1764	response to oxidative stress
YSA_RS13495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YSA_RS13500	COG0339	signal peptide processing
YSA_RS13505	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YSA_RS13525	COG0659	secondary active sulfate transmembrane transporter activity
YSA_RS13535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YSA_RS13540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YSA_RS13545	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
YSA_RS13570	COG1612	heme a metabolic process
YSA_RS13575	COG0109	protoheme IX farnesyltransferase activity
YSA_RS13590	COG2011	ABC-type metal ion transport system permease component
YSA_RS13595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
YSA_RS13610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YSA_RS13615	COG1121	(ABC) transporter
YSA_RS13620	COG0735	belongs to the Fur family
YSA_RS13625	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YSA_RS13650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
YSA_RS13655	COG3245	cytochrome
YSA_RS13665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YSA_RS13680	COG3023	N-Acetylmuramoyl-L-alanine amidase
YSA_RS13685	COG4943	cyclic-guanylate-specific phosphodiesterase activity
YSA_RS13690	COG5002	protein histidine kinase activity
YSA_RS13695	COG2204	response regulator
YSA_RS13720	COG1301	dicarboxylic acid transport
YSA_RS13725	COG0700	Nucleoside recognition
YSA_RS13740	COG1127	ABC transporter
YSA_RS13745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YSA_RS13760	COG1283	sodium-dependent phosphate transmembrane transporter activity
YSA_RS13765	COG0861	Integral membrane protein TerC family
YSA_RS13770	COG2851	Citrate transporter
YSA_RS13805	COG0427	acetyl-CoA hydrolase
YSA_RS13825	COG0583	DNA-binding transcription factor activity
YSA_RS13830	COG1960	acyl-CoA dehydrogenase activity
YSA_RS13875	COG1802	Transcriptional regulator
YSA_RS13885	COG5001	Diguanylate cyclase
YSA_RS13885	COG3300	MHYT domain
YSA_RS13890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS13915	COG2175	clavaminate synthase activity
YSA_RS13930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YSA_RS13950	COG1289	transmembrane transporter activity
YSA_RS13960	COG1566	PFAM secretion protein HlyD family protein
YSA_RS13980	COG0672	)-iron permease
YSA_RS13995	COG0625	glutathione transferase activity
YSA_RS14000	COG0165	Argininosuccinate lyase
YSA_RS14010	COG0181	hydroxymethylbilane synthase activity
YSA_RS14030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
YSA_RS14055	COG0488	(ABC) transporter
YSA_RS14070	COG1280	lysine exporter protein (LysE YggA)
YSA_RS14100	COG0516	GMP reductase activity
YSA_RS14100	COG0517	IMP dehydrogenase activity
YSA_RS14120	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS14125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YSA_RS14135	COG2199	diguanylate cyclase activity
YSA_RS14150	COG2011	ABC-type metal ion transport system permease component
YSA_RS14155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
YSA_RS14160	COG1464	Belongs to the NlpA lipoprotein family
YSA_RS14180	COG1126	abc transporter atp-binding protein
YSA_RS14185	COG0765	amino acid transport
YSA_RS14190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS14195	COG1045	serine acetyltransferase
YSA_RS14200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YSA_RS14205	COG2175	clavaminate synthase activity
YSA_RS14210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YSA_RS14215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
YSA_RS14220	COG4521	taurine ABC transporter
YSA_RS14230	COG0450	alkyl hydroperoxide reductase
YSA_RS14235	COG0431	NADPH-dependent FMN reductase
YSA_RS14240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YSA_RS14245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YSA_RS14250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YSA_RS14255	COG1116	anion transmembrane transporter activity
YSA_RS14270	COG2918	glutathione biosynthetic process
YSA_RS14280	COG2183	response to ionizing radiation
YSA_RS14295	COG0189	ligase activity
YSA_RS14300	COG0189	ligase activity
YSA_RS14300	COG4067	protein conserved in archaea
YSA_RS14305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YSA_RS14315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
YSA_RS14325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
YSA_RS14350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
YSA_RS14355	COG1652	LysM domain
YSA_RS14360	COG1011	Hydrolase
YSA_RS14365	COG0494	nUDIX hydrolase
YSA_RS14395	COG2957	Belongs to the agmatine deiminase family
YSA_RS14415	COG0069	glutamate synthase activity
YSA_RS14450	COG0582	viral genome integration into host DNA
YSA_RS14530	COG4215	(ABC) transporter
YSA_RS14570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
YSA_RS14585	COG2223	nitrite transmembrane transporter activity
YSA_RS14590	COG0131	Imidazoleglycerol-phosphate dehydratase
YSA_RS14595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YSA_RS14605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YSA_RS14610	COG0107	imidazoleglycerol-phosphate synthase activity
YSA_RS14615	COG4175	Glycine betaine
YSA_RS14620	COG4176	ABC-type proline glycine betaine transport system permease component
YSA_RS14630	COG1760	l-serine dehydratase
YSA_RS14645	COG3291	Pkd domain containing protein
YSA_RS14655	COG1250	3-hydroxyacyl-CoA dehydrogenase
YSA_RS14660	COG3246	L-lysine catabolic process to acetate
YSA_RS14700	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS14700	COG0446	pyridine nucleotide-disulphide oxidoreductase
YSA_RS14705	COG0247	lactate metabolic process
YSA_RS14705	COG2181	nitrate reductase activity
YSA_RS14710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
YSA_RS14725	COG4638	Rieske (2fe-2S)
YSA_RS14735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YSA_RS14735	COG1017	nitric oxide dioxygenase activity
YSA_RS14760	COG0840	transmembrane signaling receptor activity
YSA_RS14770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YSA_RS14800	COG1063	alcohol dehydrogenase
YSA_RS14815	COG0204	Acyl-transferase
YSA_RS14825	COG0745	RESPONSE REGULATOR receiver
YSA_RS14830	COG2205	protein histidine kinase activity
YSA_RS14835	COG4452	Inner membrane protein CreD
YSA_RS14845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YSA_RS14865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
YSA_RS14880	COG0438	transferase activity, transferring glycosyl groups
YSA_RS14920	COG4774	siderophore transport
YSA_RS14930	COG3712	iron ion homeostasis
YSA_RS14935	COG1595	DNA-templated transcription, initiation
YSA_RS14940	COG2176	DNA-directed DNA polymerase activity
YSA_RS14945	COG0516	GMP reductase activity
YSA_RS14945	COG0517	IMP dehydrogenase activity
YSA_RS14950	COG2204	response regulator
YSA_RS14955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YSA_RS14970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YSA_RS14975	COG2005	Transcriptional regulator
YSA_RS14975	COG3585	molybdate ion transport
YSA_RS14980	COG1040	competence protein
YSA_RS14985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
YSA_RS14990	COG0156	8-amino-7-oxononanoate synthase activity
YSA_RS15015	COG1960	acyl-CoA dehydrogenase activity
YSA_RS15020	COG3706	GGDEF domain
YSA_RS15025	COG1960	acyl-CoA dehydrogenase activity
YSA_RS15030	COG0583	DNA-binding transcription factor activity
YSA_RS15035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YSA_RS15050	COG0535	radical SAM domain protein
YSA_RS15060	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
YSA_RS15070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YSA_RS15080	COG1025	Belongs to the peptidase M16 family
YSA_RS15085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YSA_RS15120	COG0358	DNA primase activity
YSA_RS15125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YSA_RS15130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YSA_RS15135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
YSA_RS15140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YSA_RS15155	COG0617	tRNA 3'-terminal CCA addition
YSA_RS15160	COG2719	SpoVR family
YSA_RS15165	COG2718	Belongs to the UPF0229 family
YSA_RS15170	COG2766	serine protein kinase
YSA_RS15175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YSA_RS15180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YSA_RS15185	COG2967	ApaG domain
YSA_RS15190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YSA_RS15195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YSA_RS15200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YSA_RS15205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YSA_RS15210	COG3178	'Phosphotransferase
YSA_RS15215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
YSA_RS15230	COG4585	Histidine kinase
YSA_RS15235	COG2197	response regulator
YSA_RS15240	COG3842	ATPase activity
YSA_RS15250	COG1176	ABC-type spermidine putrescine transport system, permease component I
YSA_RS15260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YSA_RS15265	COG0546	phosphoglycolate phosphatase activity
YSA_RS15270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
YSA_RS15275	COG4625	pathogenesis
YSA_RS15275	COG3240	lipase activity
YSA_RS15280	COG0512	Glutamine amidotransferase of anthranilate synthase
YSA_RS15285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YSA_RS15290	COG0134	indole-3-glycerol-phosphate synthase activity
YSA_RS15305	COG1765	OsmC-like protein
YSA_RS15315	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
YSA_RS15320	COG0537	adenosine 5'-monophosphoramidase activity
YSA_RS15325	COG0300	oxidoreductase activity
YSA_RS15335	COG1981	membrane
YSA_RS15340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YSA_RS15345	COG0316	Belongs to the HesB IscA family
YSA_RS15350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
YSA_RS15355	COG0739	heme binding
YSA_RS15365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
YSA_RS15395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
YSA_RS15395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
YSA_RS15400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
YSA_RS15425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YSA_RS15445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YSA_RS15450	COG0081	regulation of translation
YSA_RS15455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YSA_RS15460	COG0222	ribosome binding
YSA_RS15465	COG0085	RNA polymerase activity
YSA_RS15470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YSA_RS15475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YSA_RS15480	COG0049	tRNA binding
YSA_RS15485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YSA_RS15490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YSA_RS15495	COG0051	transcription antitermination factor activity, RNA binding
YSA_RS15500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YSA_RS15505	COG0088	Forms part of the polypeptide exit tunnel
YSA_RS15510	COG0089	rRNA binding
YSA_RS15515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YSA_RS15520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YSA_RS15525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YSA_RS15530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YSA_RS15535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YSA_RS15540	COG0255	Belongs to the universal ribosomal protein uL29 family
YSA_RS15545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YSA_RS15550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YSA_RS15555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YSA_RS15560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YSA_RS15565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
YSA_RS15570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YSA_RS15575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YSA_RS15580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
YSA_RS15585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YSA_RS15590	COG1841	ribosomal large subunit assembly
YSA_RS15595	COG0200	Binds to the 23S rRNA
YSA_RS15605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YSA_RS15610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YSA_RS15615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
YSA_RS15620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YSA_RS15625	COG0202	RNA polymerase activity
YSA_RS15630	COG0203	ribosomal protein L17
YSA_RS15635	COG0753	catalase activity
YSA_RS15640	COG2193	ferroxidase activity
YSA_RS15645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YSA_RS15650	COG2814	Major facilitator Superfamily
YSA_RS15655	COG0629	single-stranded DNA binding
YSA_RS15660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS15670	COG4221	oxidoreductase activity
YSA_RS15675	COG0243	molybdopterin cofactor binding
YSA_RS15675	COG3383	formate dehydrogenase (NAD+) activity
YSA_RS15680	COG3383	formate dehydrogenase (NAD+) activity
YSA_RS15680	COG0243	molybdopterin cofactor binding
YSA_RS15685	COG0437	4 iron, 4 sulfur cluster binding
YSA_RS15690	COG2864	formate dehydrogenase
YSA_RS15695	COG3058	Necessary for formate dehydrogenase activity
YSA_RS15700	COG1921	L-seryl-tRNASec selenium transferase activity
YSA_RS15705	COG3276	selenocysteine insertion sequence binding
YSA_RS15715	COG0252	asparaginase activity
YSA_RS15720	COG1115	amino acid carrier protein
YSA_RS15755	COG2814	Major facilitator Superfamily
YSA_RS15760	COG3047	cAMP biosynthetic process
YSA_RS15780	COG0577	efflux transmembrane transporter activity
YSA_RS15780	COG1136	(ABC) transporter
YSA_RS15795	COG3118	belongs to the thioredoxin family
YSA_RS15800	COG2264	protein methyltransferase activity
YSA_RS15810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YSA_RS15815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YSA_RS15815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YSA_RS15830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YSA_RS15835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YSA_RS15840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YSA_RS15845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YSA_RS15855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YSA_RS15865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YSA_RS15870	COG4206	TonB-dependent receptor
YSA_RS15880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YSA_RS15885	COG0142	geranyltranstransferase activity
YSA_RS15890	COG1722	exodeoxyribonuclease VII activity
YSA_RS15895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YSA_RS15905	COG2819	hydrolase of the alpha beta superfamily
YSA_RS15955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YSA_RS15960	COG3228	Belongs to the MtfA family
YSA_RS15965	COG0586	Pfam SNARE associated Golgi protein
YSA_RS15970	COG0456	acetyltransferase
YSA_RS15975	COG4302	ethanolamine ammonia-lyase activity
YSA_RS15980	COG4303	Ethanolamine ammonia lyase large subunit
YSA_RS15985	COG0531	amino acid
YSA_RS15995	COG3284	Transcriptional regulator
YSA_RS16000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YSA_RS16015	COG0702	epimerase
YSA_RS16025	COG1063	alcohol dehydrogenase
YSA_RS16035	COG0022	dehydrogenase e1 component
YSA_RS16040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YSA_RS16045	COG3199	ATP-NAD kinase
YSA_RS16050	COG3284	Transcriptional regulator
YSA_RS16065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YSA_RS16100	COG0023	Translation Initiation Factor
YSA_RS16105	COG1166	arginine decarboxylase activity
YSA_RS16115	COG0534	Mate efflux family protein
YSA_RS16120	COG2373	Large extracellular alpha-helical protein
YSA_RS16130	COG4953	penicillin-binding protein 1C
YSA_RS16160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YSA_RS16170	COG2030	dehydratase
YSA_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS16185	COG2207	Transcriptional regulator
YSA_RS16190	COG0840	transmembrane signaling receptor activity
YSA_RS16200	COG2217	Heavy metal translocating P-type atpase
YSA_RS16215	COG2814	Major facilitator Superfamily
YSA_RS16230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
YSA_RS16240	COG1739	Uncharacterized protein family UPF0029
YSA_RS16245	COG1309	transcriptional regulator
YSA_RS16290	COG2995	paraquat-inducible protein a
YSA_RS16295	COG2995	paraquat-inducible protein a
YSA_RS16300	COG3008	intermembrane lipid transfer
YSA_RS16305	COG0268	Binds directly to 16S ribosomal RNA
YSA_RS16315	COG0196	riboflavin kinase activity
YSA_RS16320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
YSA_RS16325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
YSA_RS16330	COG1047	Peptidyl-prolyl cis-trans
YSA_RS16335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
YSA_RS16365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS16390	COG1172	Belongs to the binding-protein-dependent transport system permease family
YSA_RS16435	COG0542	response to heat
YSA_RS16465	COG1252	NADH dehydrogenase
YSA_RS16490	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
YSA_RS16495	COG0237	dephospho-CoA kinase activity
YSA_RS16525	COG1278	Cold shock
YSA_RS16595	COG0494	nUDIX hydrolase
YSA_RS16635	COG0039	L-malate dehydrogenase activity
YSA_RS16640	COG0765	amino acid transport
YSA_RS16645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS16650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
YSA_RS16650	COG0646	methionine synthase
YSA_RS16655	COG0626	cystathionine gamma-synthase activity
YSA_RS16660	COG0833	amino acid
YSA_RS16665	COG0583	DNA-binding transcription factor activity
YSA_RS16685	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS16700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YSA_RS16720	COG0488	(ABC) transporter
YSA_RS16725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
YSA_RS16730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YSA_RS16750	COG1067	ATP-dependent peptidase activity
YSA_RS16760	COG2862	Uncharacterized protein family, UPF0114
YSA_RS16770	COG0545	Peptidyl-prolyl cis-trans isomerase
YSA_RS16775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YSA_RS16780	COG2824	Alkylphosphonate utilization operon protein PhnA
YSA_RS16785	COG0142	geranyltranstransferase activity
YSA_RS16790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
YSA_RS16795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
YSA_RS16800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YSA_RS16805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
YSA_RS16810	COG3045	CreA protein
YSA_RS16840	COG0456	acetyltransferase
YSA_RS16870	COG2223	nitrite transmembrane transporter activity
YSA_RS16880	COG3712	iron ion homeostasis
YSA_RS16885	COG1595	DNA-templated transcription, initiation
YSA_RS16895	COG2169	Transcriptional regulator
YSA_RS16895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YSA_RS16900	COG3264	Mechanosensitive ion channel
YSA_RS16900	COG1511	domain protein
YSA_RS16930	COG1335	isochorismatase
YSA_RS16945	COG0628	permease
YSA_RS16975	COG0193	aminoacyl-tRNA hydrolase activity
YSA_RS16980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
YSA_RS16985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YSA_RS16995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
YSA_RS17000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
YSA_RS17030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YSA_RS17035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YSA_RS17045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YSA_RS17050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
YSA_RS17065	COG0415	Belongs to the DNA photolyase family
YSA_RS17070	COG0789	Transcriptional regulator
YSA_RS17080	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
YSA_RS17085	COG1090	epimerase
YSA_RS17090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
YSA_RS17100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YSA_RS17105	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YSA_RS17130	COG0579	oxidoreductase
YSA_RS17170	COG2135	peptidase activity
YSA_RS17180	COG2119	membrane
YSA_RS17185	COG2813	Specifically methylates the guanine in position
YSA_RS17190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YSA_RS17200	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS17240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YSA_RS17245	COG2885	chlorophyll binding
YSA_RS17250	COG0280	phosphate acetyltransferase
YSA_RS17250	COG0857	belongs to the CobB CobQ family
YSA_RS17265	COG0386	Belongs to the glutathione peroxidase family
YSA_RS17295	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YSA_RS17300	COG0492	ferredoxin-NADP+ reductase activity
YSA_RS17315	COG3023	N-Acetylmuramoyl-L-alanine amidase
YSA_RS17325	COG0084	hydrolase, TatD family'
YSA_RS17330	COG1609	Transcriptional regulator
YSA_RS17340	COG1105	Belongs to the carbohydrate kinase PfkB family
YSA_RS17345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YSA_RS17345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YSA_RS17345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YSA_RS17350	COG3530	Putative quorum-sensing-regulated virulence factor
YSA_RS17360	COG5001	Diguanylate cyclase
YSA_RS17360	COG4251	negative regulation of phosphorylation
YSA_RS17360	COG3706	GGDEF domain
YSA_RS17360	COG2203	Gaf domain
YSA_RS17410	COG3604	Transcriptional regulator
YSA_RS17415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YSA_RS17415	COG1017	nitric oxide dioxygenase activity
YSA_RS17425	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
YSA_RS17430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YSA_RS17435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YSA_RS17440	COG1845	cytochrome c oxidase, subunit III
YSA_RS17445	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YSA_RS17450	COG0109	protoheme IX farnesyltransferase activity
YSA_RS17455	COG0436	Aminotransferase
YSA_RS17465	COG0727	PFAM Uncharacterised protein family (UPF0153)
YSA_RS17475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YSA_RS17480	COG1595	DNA-templated transcription, initiation
YSA_RS17505	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YSA_RS17510	COG0709	Synthesizes selenophosphate from selenide and ATP
YSA_RS17515	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YSA_RS17520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
YSA_RS17525	COG3639	organic phosphonate transmembrane transporter activity
YSA_RS17530	COG3639	organic phosphonate transmembrane transporter activity
YSA_RS17535	COG3781	membrane
YSA_RS17540	COG3657	addiction module killer protein
YSA_RS17585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YSA_RS17590	COG0343	queuine tRNA-ribosyltransferase activity
YSA_RS17595	COG1862	Preprotein translocase
YSA_RS17610	COG3134	Outer membrane lipoprotein
YSA_RS17635	COG1045	serine acetyltransferase
YSA_RS17645	COG1104	cysteine desulfurase activity
YSA_RS17655	COG0316	Belongs to the HesB IscA family
YSA_RS17660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YSA_RS17665	COG0443	Heat shock 70 kDa protein
YSA_RS17670	COG0633	Ferredoxin
YSA_RS17680	COG0105	UTP biosynthetic process
YSA_RS17685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
YSA_RS17700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
YSA_RS17705	COG0124	histidyl-tRNA synthetase
YSA_RS17720	COG1160	GTP binding
YSA_RS17725	COG0436	Aminotransferase
YSA_RS17740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YSA_RS17745	COG4774	siderophore transport
YSA_RS17750	COG3128	pkhd-type hydroxylase
YSA_RS17765	COG0019	diaminopimelate decarboxylase activity
YSA_RS17770	COG1595	DNA-templated transcription, initiation
YSA_RS17780	COG4772	TonB-dependent receptor
YSA_RS17810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
YSA_RS17825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS17825	COG0723	plastoquinol--plastocyanin reductase activity
YSA_RS17850	COG4608	Belongs to the ABC transporter superfamily
YSA_RS17855	COG0444	Belongs to the ABC transporter superfamily
YSA_RS17860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YSA_RS17865	COG0601	transmembrane transport
YSA_RS17870	COG0747	negative chemotaxis
YSA_RS17880	COG0747	negative chemotaxis
YSA_RS17885	COG0747	negative chemotaxis
YSA_RS17900	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
YSA_RS17920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YSA_RS17925	COG0693	protein deglycase activity
YSA_RS17940	COG3153	acetyltransferase
YSA_RS17940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YSA_RS17970	COG0642	Histidine kinase
YSA_RS17980	COG3642	lipopolysaccharide core region biosynthetic process
YSA_RS17990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YSA_RS17995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS18035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YSA_RS18045	COG0583	DNA-binding transcription factor activity
YSA_RS18050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YSA_RS18060	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS18095	COG1113	amino acid transport
YSA_RS18110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YSA_RS18115	COG0154	amidase activity
YSA_RS18120	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YSA_RS18125	COG1077	Cell shape determining protein MreB Mrl
YSA_RS18130	COG1792	Involved in formation and maintenance of cell shape
YSA_RS18140	COG0424	maF-like protein
YSA_RS18155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YSA_RS18160	COG0312	modulator of DNA gyrase
YSA_RS18165	COG3028	Belongs to the UPF0307 family
YSA_RS18170	COG0312	modulator of DNA gyrase
YSA_RS18200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YSA_RS18205	COG1660	Displays ATPase and GTPase activities
YSA_RS18215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YSA_RS18220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YSA_RS18225	COG1137	ATPase activity
YSA_RS18230	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YSA_RS18240	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YSA_RS18250	COG1127	ABC transporter
YSA_RS18255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YSA_RS18260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YSA_RS18280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YSA_RS18285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
YSA_RS18290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YSA_RS18295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YSA_RS18305	COG2186	Transcriptional regulator
YSA_RS18310	COG2807	transmembrane transport
YSA_RS18320	COG2827	Endonuclease containing a URI domain
YSA_RS18325	COG3081	Nucleoid-associated protein
YSA_RS18330	COG0776	regulation of translation
YSA_RS18335	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
YSA_RS18340	COG0525	valine-tRNA ligase activity
YSA_RS18355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YSA_RS18365	COG0795	lipopolysaccharide-transporting ATPase activity
YSA_RS18370	COG0795	lipopolysaccharide-transporting ATPase activity
YSA_RS18380	COG1278	Cold shock
YSA_RS18385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YSA_RS18390	COG1760	l-serine dehydratase
YSA_RS18395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YSA_RS18395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YSA_RS18400	COG0509	glycine decarboxylation via glycine cleavage system
YSA_RS18415	COG3220	belongs to the UPF0276 family
YSA_RS18425	COG1595	DNA-templated transcription, initiation
YSA_RS18430	COG4944	Protein of unknown function (DUF1109)
YSA_RS18435	COG0786	glutamate:sodium symporter activity
YSA_RS18455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YSA_RS18460	COG2235	arginine
YSA_RS18475	COG2832	Protein of unknown function (DUF454)
YSA_RS18530	COG1653	transport
YSA_RS18535	COG1175	transmembrane transport
YSA_RS18545	COG3842	ATPase activity
YSA_RS18555	COG0676	glucose-6-phosphate 1-epimerase activity
YSA_RS18560	COG1737	Transcriptional regulator
YSA_RS18575	COG0800	Aldolase
YSA_RS18590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YSA_RS18600	COG0739	heme binding
YSA_RS18605	COG1570	exodeoxyribonuclease VII activity
YSA_RS18610	COG0583	DNA-binding transcription factor activity
YSA_RS18630	COG0519	Catalyzes the synthesis of GMP from XMP
YSA_RS18630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YSA_RS18635	COG1397	ADP-ribosylglycohydrolase
YSA_RS18640	COG2369	cell adhesion
YSA_RS18650	COG0590	tRNA wobble adenosine to inosine editing
YSA_RS18655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
YSA_RS18660	COG0047	phosphoribosylformylglycinamidine synthase activity
YSA_RS18660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
YSA_RS18675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YSA_RS18680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YSA_RS18710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YSA_RS18755	COG2375	cellular response to nickel ion
YSA_RS18760	COG1695	Transcriptional regulator
YSA_RS18770	COG1113	amino acid transport
YSA_RS18775	COG0069	glutamate synthase activity
YSA_RS18780	COG1201	RNA secondary structure unwinding
YSA_RS18785	COG0494	nUDIX hydrolase
YSA_RS18790	COG0583	DNA-binding transcription factor activity
YSA_RS18795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YSA_RS18815	COG1126	abc transporter atp-binding protein
YSA_RS18820	COG0765	amino acid transport
YSA_RS18825	COG0765	amino acid transport
YSA_RS18830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS18850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YSA_RS18860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YSA_RS18865	COG3842	ATPase activity
YSA_RS18870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YSA_RS18875	COG0243	molybdopterin cofactor binding
YSA_RS18880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YSA_RS18900	COG0450	alkyl hydroperoxide reductase
YSA_RS18905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YSA_RS18910	COG0418	dihydroorotase activity
YSA_RS18920	COG0137	argininosuccinate synthase activity
YSA_RS18930	COG2197	response regulator
YSA_RS18935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YSA_RS18945	COG4659	FMN binding
YSA_RS18955	COG4657	Part of a membrane complex involved in electron transport
YSA_RS18960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YSA_RS18960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YSA_RS18965	COG0489	protein tyrosine kinase activity
YSA_RS18970	COG1278	Cold shock
YSA_RS18975	COG0717	Belongs to the dCTP deaminase family
YSA_RS18990	COG1201	RNA secondary structure unwinding
YSA_RS19000	COG1793	dna ligase
YSA_RS19005	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YSA_RS19005	COG1793	dna ligase
YSA_RS19010	COG2366	antibiotic biosynthetic process
YSA_RS19015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS19020	COG1045	serine acetyltransferase
YSA_RS19025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YSA_RS19030	COG2814	Major facilitator Superfamily
YSA_RS19045	COG0653	protein targeting
YSA_RS19055	COG3012	SEC-C Motif Domain Protein
YSA_RS19085	COG1199	ATP-dependent helicase activity
YSA_RS19105	COG0259	pyridoxamine-phosphate oxidase activity
YSA_RS19120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YSA_RS19125	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
YSA_RS19165	COG2084	Dehydrogenase
YSA_RS19175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YSA_RS19190	COG1289	transmembrane transporter activity
YSA_RS19210	COG3300	MHYT domain
YSA_RS19210	COG5001	Diguanylate cyclase
YSA_RS19215	COG3706	GGDEF domain
YSA_RS19220	COG2116	formate transmembrane transporter activity
YSA_RS19265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YSA_RS19275	COG0252	asparaginase activity
YSA_RS19280	COG3318	Belongs to the UPF0149 family
YSA_RS19280	COG3012	SEC-C Motif Domain Protein
YSA_RS19285	COG0625	glutathione transferase activity
YSA_RS19295	COG0583	DNA-binding transcription factor activity
YSA_RS19320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YSA_RS19330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YSA_RS19345	COG3077	Addiction module antitoxin, RelB DinJ family
YSA_RS19355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YSA_RS19360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YSA_RS19360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YSA_RS19365	COG0745	RESPONSE REGULATOR receiver
YSA_RS19370	COG2205	protein histidine kinase activity
YSA_RS19405	COG1301	dicarboxylic acid transport
YSA_RS19415	COG4807	Protein conserved in bacteria
YSA_RS19425	COG0519	Catalyzes the synthesis of GMP from XMP
YSA_RS19450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YSA_RS19455	COG3158	transport of potassium into the cell
YSA_RS19485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YSA_RS19495	COG0442	prolyl-tRNA aminoacylation
YSA_RS19510	COG2900	Belongs to the SlyX family
YSA_RS19520	COG0783	Belongs to the Dps family
YSA_RS19525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YSA_RS19540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YSA_RS19545	COG0217	transcriptional regulatory protein
YSA_RS19550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
YSA_RS19555	COG0632	four-way junction helicase activity
YSA_RS19560	COG2255	four-way junction helicase activity
YSA_RS19565	COG0824	Thioesterase
YSA_RS19585	COG0823	Involved in the tonB-independent uptake of proteins
YSA_RS19590	COG2885	chlorophyll binding
YSA_RS19595	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YSA_RS19600	COG0602	queuosine metabolic process
YSA_RS19605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YSA_RS19620	COG0840	transmembrane signaling receptor activity
YSA_RS19625	COG0531	amino acid
YSA_RS19630	COG5339	Protein conserved in bacteria
YSA_RS19635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
YSA_RS19645	COG0425	Belongs to the sulfur carrier protein TusA family
YSA_RS19655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YSA_RS19665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YSA_RS19670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YSA_RS19675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YSA_RS19680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
YSA_RS19805	COG0616	signal peptide processing
YSA_RS19910	COG3179	chitinase
YSA_RS20020	COG0579	oxidoreductase
YSA_RS20025	COG0640	Transcriptional regulator
YSA_RS20030	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS20045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YSA_RS20050	COG3938	Belongs to the proline racemase family
YSA_RS20055	COG0531	amino acid
YSA_RS20065	COG0583	DNA-binding transcription factor activity
YSA_RS20070	COG0521	Mo-molybdopterin cofactor biosynthetic process
YSA_RS20075	COG3781	membrane
YSA_RS20080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YSA_RS20090	COG1522	sequence-specific DNA binding
YSA_RS20095	COG0626	cystathionine gamma-synthase activity
YSA_RS20120	COG3100	YcgL domain-containing protein
YSA_RS20135	COG2983	Belongs to the UPF0260 family
YSA_RS20180	COG0121	glutamine amidotransferase
YSA_RS20195	COG2814	Major facilitator Superfamily
YSA_RS20200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
YSA_RS20205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
YSA_RS20210	COG1984	allophanate hydrolase subunit 2
YSA_RS20230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YSA_RS20255	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
YSA_RS20280	COG1295	ribonuclease BN
YSA_RS20285	COG0242	peptide deformylase activity
YSA_RS20305	COG3795	YCII-related domain
YSA_RS20315	COG4941	Belongs to the sigma-70 factor family
YSA_RS20320	COG2030	dehydratase
YSA_RS20325	COG2267	carboxylic ester hydrolase activity
YSA_RS20330	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS20335	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS20340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS20345	COG0174	glutamine synthetase
YSA_RS20350	COG1643	Atp-dependent helicase
YSA_RS20360	COG2188	Transcriptional regulator
YSA_RS20370	COG1132	(ABC) transporter
YSA_RS20380	COG2267	carboxylic ester hydrolase activity
YSA_RS20395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YSA_RS20425	COG0668	transmembrane transport
YSA_RS20430	COG0513	Belongs to the DEAD box helicase family
YSA_RS20465	COG0583	DNA-binding transcription factor activity
YSA_RS20485	COG0840	transmembrane signaling receptor activity
YSA_RS20500	COG2832	Protein of unknown function (DUF454)
YSA_RS20515	COG0514	ATP-dependent DNA helicase (RecQ)
YSA_RS20525	COG1752	Esterase of the alpha-beta hydrolase superfamily
YSA_RS20540	COG2207	Transcriptional regulator
YSA_RS20560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YSA_RS20565	COG0778	Nitroreductase
YSA_RS20580	COG0745	RESPONSE REGULATOR receiver
YSA_RS20590	COG2350	Protein conserved in bacteria
YSA_RS20595	COG2917	probably involved in intracellular septation
YSA_RS20600	COG0613	PHP domain protein
YSA_RS20605	COG0009	L-threonylcarbamoyladenylate synthase
YSA_RS20615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
YSA_RS20625	COG1113	amino acid transport
YSA_RS20635	COG0247	lactate metabolic process
YSA_RS20635	COG0277	FAD linked oxidase domain protein
YSA_RS20650	COG2154	pterin-4-alpha-carbinolamine dehydratase
YSA_RS20675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YSA_RS20680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS20685	COG4215	(ABC) transporter
YSA_RS20705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YSA_RS20720	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS20725	COG3724	N-succinylarginine dihydrolase activity
YSA_RS20735	COG2988	succinylglutamate desuccinylase activity
YSA_RS20740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YSA_RS20745	COG0527	aspartate kinase activity
YSA_RS20750	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YSA_RS20780	COG2239	Acts as a magnesium transporter
YSA_RS20800	COG1113	amino acid transport
YSA_RS20810	COG3706	GGDEF domain
YSA_RS20815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YSA_RS20825	COG0022	dehydrogenase e1 component
YSA_RS20830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YSA_RS20835	COG1522	sequence-specific DNA binding
YSA_RS20845	COG0477	Major facilitator Superfamily
YSA_RS20850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
YSA_RS20870	COG0784	Response regulator, receiver
YSA_RS20870	COG0835	chemotaxis
YSA_RS20875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YSA_RS20880	COG1815	bacterial-type flagellum-dependent cell motility
YSA_RS20905	COG4787	bacterial-type flagellum-dependent cell motility
YSA_RS20915	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YSA_RS20920	COG1706	bacterial-type flagellum-dependent cell motility
YSA_RS20965	COG0438	transferase activity, transferring glycosyl groups
YSA_RS20965	COG1216	Glycosyl transferase, family 2
YSA_RS20970	COG2089	acid synthase
YSA_RS20975	COG0028	Belongs to the TPP enzyme family
YSA_RS20980	COG0275	rRNA processing
YSA_RS20985	COG1088	dTDP-glucose 4,6-dehydratase activity
YSA_RS20995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YSA_RS21040	COG1677	Flagellar hook-basal body complex protein FliE
YSA_RS21065	COG2882	bacterial-type flagellum organization
YSA_RS21080	COG0745	RESPONSE REGULATOR receiver
YSA_RS21120	COG1987	bacterial-type flagellum assembly
YSA_RS21145	COG1104	cysteine desulfurase activity
YSA_RS21165	COG1181	Belongs to the D-alanine--D-alanine ligase family
YSA_RS21170	COG1802	Transcriptional regulator
YSA_RS21175	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YSA_RS21200	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YSA_RS21205	COG0784	Response regulator, receiver
YSA_RS21205	COG2198	Histidine kinase
YSA_RS21205	COG0643	Histidine kinase
YSA_RS21210	COG2201	protein-glutamate methylesterase activity
YSA_RS21215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YSA_RS21220	COG1360	Flagellar Motor Protein
YSA_RS21225	COG1192	Involved in chromosome partitioning
YSA_RS21235	COG0835	chemotaxis
YSA_RS21250	COG2257	FlhB HrpN YscU SpaS Family
YSA_RS21260	COG4133	protoheme IX ABC transporter activity
YSA_RS21280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
YSA_RS21285	COG1138	Cytochrome C-type biogenesis protein
YSA_RS21315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YSA_RS21350	COG1953	Uracil, thiamine, allantoin
YSA_RS21355	COG1522	sequence-specific DNA binding
YSA_RS21365	COG0116	Belongs to the methyltransferase superfamily
YSA_RS21365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YSA_RS21380	COG0477	Major facilitator Superfamily
YSA_RS21395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YSA_RS21405	COG0469	pyruvate kinase activity
YSA_RS21415	COG2084	Dehydrogenase
YSA_RS21425	COG3622	Belongs to the hyi family
YSA_RS21430	COG3960	tartronate-semialdehyde synthase activity
YSA_RS21445	COG2354	Protein conserved in bacteria
YSA_RS21460	COG2233	PERMEase
YSA_RS21470	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
YSA_RS21495	COG2252	PERMEase
YSA_RS21505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YSA_RS21510	COG0402	S-adenosylhomocysteine deaminase activity
YSA_RS21520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YSA_RS21540	COG3115	cell septum assembly
YSA_RS21545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YSA_RS21555	COG0789	Transcriptional regulator
YSA_RS21575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YSA_RS21580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YSA_RS21590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
YSA_RS21595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YSA_RS21600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YSA_RS21620	COG2217	Heavy metal translocating P-type atpase
YSA_RS21630	COG0348	domain, Protein
YSA_RS21635	COG2010	Cytochrome c
YSA_RS21650	COG3278	Belongs to the heme-copper respiratory oxidase family
YSA_RS21660	COG2010	Cytochrome c
YSA_RS21675	COG3278	Belongs to the heme-copper respiratory oxidase family
YSA_RS21685	COG3123	guanosine phosphorylase activity
YSA_RS21730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YSA_RS21765	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
YSA_RS21765	COG3608	succinylglutamate desuccinylase aspartoacylase
YSA_RS21770	COG2068	MobA-Related Protein
YSA_RS21815	COG0642	Histidine kinase
YSA_RS21855	COG0477	Major facilitator Superfamily
YSA_RS21865	COG2944	sequence-specific DNA binding
YSA_RS21895	COG2885	chlorophyll binding
YSA_RS21900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS21925	COG2009	succinate dehydrogenase
YSA_RS21930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YSA_RS21935	COG1053	succinate dehydrogenase
YSA_RS21955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YSA_RS21960	COG0045	succinate-CoA ligase (ADP-forming) activity
YSA_RS22020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YSA_RS22040	COG0577	efflux transmembrane transporter activity
YSA_RS22040	COG1136	(ABC) transporter
YSA_RS22045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS22065	COG0326	Molecular chaperone. Has ATPase activity
YSA_RS22075	COG1741	Belongs to the pirin family
YSA_RS22090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YSA_RS22095	COG2205	protein histidine kinase activity
YSA_RS22095	COG3850	Histidine kinase
YSA_RS22095	COG3437	response regulator, receiver
YSA_RS22095	COG4999	Histidine kinase
YSA_RS22110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YSA_RS22145	COG0628	permease
YSA_RS22155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
YSA_RS22165	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
YSA_RS22170	COG2205	protein histidine kinase activity
YSA_RS22175	COG0745	RESPONSE REGULATOR receiver
YSA_RS22180	COG0583	DNA-binding transcription factor activity
YSA_RS22185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YSA_RS22195	COG4172	Belongs to the ABC transporter superfamily
YSA_RS22200	COG4239	(ABC) transporter, permease
YSA_RS22205	COG4174	ABC transporter (Permease)
YSA_RS22210	COG4166	transmembrane transport
YSA_RS22215	COG4166	transmembrane transport
YSA_RS22220	COG0741	lytic transglycosylase activity
YSA_RS22220	COG1388	LysM domain
YSA_RS22225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YSA_RS22235	COG0328	RNA-DNA hybrid ribonuclease activity
YSA_RS22255	COG0431	NADPH-dependent FMN reductase
YSA_RS22290	COG1007	ATP synthesis coupled electron transport
YSA_RS22305	COG0713	ATP synthesis coupled electron transport
YSA_RS22315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YSA_RS22320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
YSA_RS22325	COG1034	ATP synthesis coupled electron transport
YSA_RS22340	COG0649	NAD binding
YSA_RS22340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YSA_RS22345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YSA_RS22350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YSA_RS22385	COG0659	secondary active sulfate transmembrane transporter activity
YSA_RS22390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YSA_RS22405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YSA_RS22410	COG0583	DNA-binding transcription factor activity
YSA_RS22415	COG1113	amino acid transport
YSA_RS22420	COG2050	protein possibly involved in aromatic compounds catabolism
YSA_RS22420	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YSA_RS22425	COG0625	glutathione transferase activity
YSA_RS22435	COG0306	phosphate transporter
YSA_RS22445	COG0456	acetyltransferase
YSA_RS22445	COG1846	Transcriptional regulator
YSA_RS22460	COG0322	excinuclease ABC activity
YSA_RS22500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YSA_RS22515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YSA_RS22520	COG1960	acyl-CoA dehydrogenase activity
YSA_RS22530	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS22540	COG0366	Alpha amylase catalytic
YSA_RS22545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
YSA_RS22555	COG3568	Endonuclease Exonuclease Phosphatase
YSA_RS22575	COG1640	4-alpha-glucanotransferase
YSA_RS22580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
YSA_RS22585	COG0297	glycogen (starch) synthase activity
YSA_RS22590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
YSA_RS22595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YSA_RS22600	COG3387	PFAM Glycoside hydrolase 15-related
YSA_RS22610	COG1309	transcriptional regulator
YSA_RS22620	COG0493	'glutamate synthase
YSA_RS22630	COG1953	Uracil, thiamine, allantoin
YSA_RS22640	COG1234	tRNA 3'-trailer cleavage
YSA_RS22645	COG3040	lipid binding
YSA_RS22650	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YSA_RS22655	COG1024	Enoyl-CoA hydratase
YSA_RS22660	COG2816	NAD+ diphosphatase activity
YSA_RS22685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS22690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YSA_RS22695	COG2153	protein acetylation
YSA_RS22700	COG2850	peptidyl-arginine hydroxylation
YSA_RS22710	COG2915	High frequency lysogenization protein hflD homolog
YSA_RS22715	COG0482	sulfurtransferase activity
YSA_RS22735	COG1278	Cold shock
YSA_RS22740	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
YSA_RS22745	COG0542	response to heat
YSA_RS22750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YSA_RS22755	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
YSA_RS22760	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
YSA_RS22765	COG1674	ftsk spoiiie
YSA_RS22770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
YSA_RS22775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YSA_RS22780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YSA_RS22785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YSA_RS22790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YSA_RS22790	COG1648	precorrin-2 dehydrogenase activity
YSA_RS22795	COG0435	Glutathione S-transferase
YSA_RS22800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YSA_RS22805	COG2920	part of a sulfur-relay system
YSA_RS22825	COG2233	PERMEase
YSA_RS22840	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS22850	COG1850	ribulose-bisphosphate carboxylase activity
YSA_RS22860	COG0477	Major facilitator Superfamily
YSA_RS22865	COG0469	pyruvate kinase activity
YSA_RS22870	COG0148	phosphopyruvate hydratase activity
YSA_RS22875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YSA_RS22895	COG0583	DNA-binding transcription factor activity
YSA_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS22920	COG0523	cobalamin synthesis protein
YSA_RS22945	COG0667	Aldo Keto reductase
YSA_RS23045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YSA_RS23050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YSA_RS23055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
YSA_RS23080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YSA_RS23090	COG4948	Mandelate Racemase Muconate Lactonizing
YSA_RS23095	COG0747	negative chemotaxis
YSA_RS23100	COG0601	transmembrane transport
YSA_RS23105	COG0747	negative chemotaxis
YSA_RS23110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YSA_RS23115	COG0444	Belongs to the ABC transporter superfamily
YSA_RS23120	COG4608	Belongs to the ABC transporter superfamily
YSA_RS23135	COG1725	Transcriptional regulator
YSA_RS23150	COG1309	transcriptional regulator
YSA_RS23155	COG2010	Cytochrome c
YSA_RS23155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YSA_RS23160	COG2080	2 iron, 2 sulfur cluster binding
YSA_RS23170	COG1846	Transcriptional regulator
YSA_RS23175	COG2309	aminopeptidase activity
YSA_RS23180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YSA_RS23185	COG0596	Alpha beta hydrolase
YSA_RS23190	COG3473	Maleate cis-trans isomerase
YSA_RS23195	COG1335	isochorismatase
YSA_RS23200	COG2271	Major facilitator Superfamily
YSA_RS23230	COG2199	diguanylate cyclase activity
YSA_RS23235	COG0490	domain, Protein
YSA_RS23235	COG0471	metal ion transport
YSA_RS23260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YSA_RS23265	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS23285	COG0616	signal peptide processing
YSA_RS23365	COG5532	Uncharacterized conserved protein (DUF2303)
YSA_RS23400	COG2963	transposase activity
YSA_RS23410	COG2433	Pfam Transposase IS66
YSA_RS23455	COG0305	Participates in initiation and elongation during chromosome replication
YSA_RS23535	COG4695	Portal protein
YSA_RS23540	COG0740	serine-type endopeptidase activity
YSA_RS23655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YSA_RS23785	COG1090	epimerase
YSA_RS23805	COG1064	alcohol dehydrogenase
YSA_RS23815	COG2259	Doxx family
YSA_RS23825	COG4191	Histidine kinase
YSA_RS23825	COG0784	Response regulator, receiver
YSA_RS23830	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
YSA_RS23835	COG0745	RESPONSE REGULATOR receiver
YSA_RS23840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YSA_RS23850	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
YSA_RS23880	COG2863	cytochrome
YSA_RS23885	COG3258	Cytochrome c
YSA_RS23905	COG3842	ATPase activity
YSA_RS23910	COG1177	transmembrane transport
YSA_RS23915	COG1176	ABC-type spermidine putrescine transport system, permease component I
YSA_RS23925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
YSA_RS23940	COG0583	DNA-binding transcription factor activity
YSA_RS23985	COG1121	(ABC) transporter
YSA_RS24025	COG1686	Belongs to the peptidase S11 family
YSA_RS24035	COG4974	Belongs to the 'phage' integrase family
YSA_RS24055	COG2020	methyltransferase activity
YSA_RS24065	COG1309	transcriptional regulator
YSA_RS24105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YSA_RS24140	COG2198	Histidine kinase
YSA_RS24140	COG0784	Response regulator, receiver
YSA_RS24140	COG2205	protein histidine kinase activity
YSA_RS24145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YSA_RS24160	COG0784	Response regulator, receiver
YSA_RS24160	COG2198	Histidine kinase
YSA_RS24160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS24160	COG2205	protein histidine kinase activity
YSA_RS24170	COG1250	3-hydroxyacyl-CoA dehydrogenase
YSA_RS24175	COG0183	Belongs to the thiolase family
YSA_RS24185	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YSA_RS24190	COG2807	transmembrane transport
YSA_RS24205	COG3193	protein, possibly involved in utilization of glycolate and propanediol
YSA_RS24210	COG0247	lactate metabolic process
YSA_RS24215	COG0277	FAD linked oxidase domain protein
YSA_RS24220	COG0277	FAD linked oxidase domain protein
YSA_RS24225	COG2186	Transcriptional regulator
YSA_RS24240	COG0768	penicillin binding
YSA_RS24280	COG0577	efflux transmembrane transporter activity
YSA_RS24290	COG1024	Enoyl-CoA hydratase
YSA_RS24315	COG0833	amino acid
YSA_RS24320	COG1024	Enoyl-CoA hydratase
YSA_RS24325	COG1960	acyl-CoA dehydrogenase activity
YSA_RS24340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YSA_RS24355	COG2249	NAD(P)H dehydrogenase (quinone) activity
YSA_RS24375	COG3192	ethanolamine utilization protein
YSA_RS24405	COG4948	Mandelate Racemase Muconate Lactonizing
YSA_RS24410	COG4829	muconolactone delta-isomerase
YSA_RS24415	COG3485	protocatechuate 3,4-dioxygenase
YSA_RS24425	COG5001	Diguanylate cyclase
YSA_RS24430	COG0656	L-ascorbic acid biosynthetic process
YSA_RS24445	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
YSA_RS24455	COG0477	Major facilitator Superfamily
YSA_RS24465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YSA_RS24470	COG3300	MHYT domain
YSA_RS24470	COG5001	Diguanylate cyclase
YSA_RS24475	COG1611	Belongs to the LOG family
YSA_RS24480	COG2855	membrane
YSA_RS24490	COG2030	dehydratase
YSA_RS24500	COG2814	Major facilitator Superfamily
YSA_RS24515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
YSA_RS24530	COG1280	lysine exporter protein (LysE YggA)
YSA_RS24535	COG4191	Histidine kinase
YSA_RS24535	COG0784	Response regulator, receiver
YSA_RS24540	COG2816	NAD+ diphosphatase activity
YSA_RS24545	COG2186	Transcriptional regulator
YSA_RS24550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YSA_RS24560	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS24565	COG2267	carboxylic ester hydrolase activity
YSA_RS24575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YSA_RS24585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
YSA_RS24600	COG1959	2 iron, 2 sulfur cluster binding
YSA_RS24605	COG2207	Transcriptional regulator
YSA_RS24625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YSA_RS24630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YSA_RS24640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YSA_RS24650	COG4991	sh3 domain protein
YSA_RS24665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YSA_RS24705	COG1944	ATP diphosphatase activity
YSA_RS24745	COG4335	DNA alkylation repair
YSA_RS24770	COG2186	Transcriptional regulator
YSA_RS24775	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS24780	COG2721	sulfolactate sulfo-lyase activity
YSA_RS24785	COG2271	Major facilitator Superfamily
YSA_RS24790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YSA_RS24805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YSA_RS24820	COG1131	(ABC) transporter
YSA_RS24905	COG5002	protein histidine kinase activity
YSA_RS24905	COG2205	protein histidine kinase activity
YSA_RS24905	COG0784	Response regulator, receiver
YSA_RS24940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS24945	COG0583	DNA-binding transcription factor activity
YSA_RS24950	COG3048	D-serine ammonia-lyase activity
YSA_RS24955	COG2610	gluconate transmembrane transporter activity
YSA_RS24965	COG1305	Transglutaminase-like
YSA_RS24975	COG2308	Evidence 4 Homologs of previously reported genes of
YSA_RS24995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YSA_RS25005	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS25015	COG0583	DNA-binding transcription factor activity
YSA_RS25020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YSA_RS25035	COG0678	peroxiredoxin activity
YSA_RS25035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YSA_RS25040	COG0583	DNA-binding transcription factor activity
YSA_RS25055	COG1473	amidohydrolase
YSA_RS25070	COG0708	Exodeoxyribonuclease III
YSA_RS25110	COG0431	NADPH-dependent FMN reductase
YSA_RS25115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YSA_RS25120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YSA_RS25125	COG0640	Transcriptional regulator
YSA_RS25140	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS25150	COG0693	protein deglycase activity
YSA_RS25155	COG2323	membrane
YSA_RS25185	COG3046	protein related to deoxyribodipyrimidine photolyase
YSA_RS25200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YSA_RS25215	COG4221	oxidoreductase activity
YSA_RS25225	COG1366	Belongs to the anti-sigma-factor antagonist family
YSA_RS25230	COG0789	Transcriptional regulator
YSA_RS25235	COG0668	transmembrane transport
YSA_RS25255	COG0589	response to stress
YSA_RS25325	COG1129	ABC transporter
YSA_RS25330	COG1172	Belongs to the binding-protein-dependent transport system permease family
YSA_RS25335	COG1172	Belongs to the binding-protein-dependent transport system permease family
YSA_RS25340	COG1960	acyl-CoA dehydrogenase activity
YSA_RS25345	COG0431	NADPH-dependent FMN reductase
YSA_RS25370	COG1172	Belongs to the binding-protein-dependent transport system permease family
YSA_RS25380	COG3829	transcription factor binding
YSA_RS25390	COG4175	Glycine betaine
YSA_RS25395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YSA_RS25400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YSA_RS25410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YSA_RS25455	COG2249	NAD(P)H dehydrogenase (quinone) activity
YSA_RS25470	COG0604	alcohol dehydrogenase
YSA_RS25470	COG3321	synthase
YSA_RS25470	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS25495	COG4948	Mandelate Racemase Muconate Lactonizing
YSA_RS25505	COG0583	DNA-binding transcription factor activity
YSA_RS25510	COG2721	sulfolactate sulfo-lyase activity
YSA_RS25525	COG2271	Major facilitator Superfamily
YSA_RS25535	COG1199	ATP-dependent helicase activity
YSA_RS25535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YSA_RS25545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YSA_RS25550	COG0829	nickel cation binding
YSA_RS25555	COG0831	urea catabolic process
YSA_RS25560	COG0832	Belongs to the urease beta subunit family
YSA_RS25565	COG0804	urea catabolic process
YSA_RS25570	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
YSA_RS25580	COG0830	nickel cation binding
YSA_RS25585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YSA_RS25655	COG0840	transmembrane signaling receptor activity
YSA_RS25660	COG1968	undecaprenyl-diphosphatase activity
YSA_RS25680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YSA_RS25685	COG1252	NADH dehydrogenase
YSA_RS25695	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS25695	COG0446	pyridine nucleotide-disulphide oxidoreductase
YSA_RS25705	COG0235	Class ii aldolase
YSA_RS25715	COG0393	Putative heavy-metal-binding
YSA_RS25755	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS25770	COG1917	Cupin 2, conserved barrel domain protein
YSA_RS25770	COG1396	sequence-specific DNA binding
YSA_RS25775	COG0477	Major facilitator Superfamily
YSA_RS25780	COG3038	cytochrome b561
YSA_RS25790	COG1595	DNA-templated transcription, initiation
YSA_RS25800	COG0708	Exodeoxyribonuclease III
YSA_RS25810	COG0729	surface antigen
YSA_RS25850	COG2366	antibiotic biosynthetic process
YSA_RS25855	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YSA_RS25865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YSA_RS25870	COG0215	cysteine-tRNA ligase activity
YSA_RS25875	COG2205	protein histidine kinase activity
YSA_RS25880	COG0745	RESPONSE REGULATOR receiver
YSA_RS25885	COG1802	Transcriptional regulator
YSA_RS25895	COG0579	oxidoreductase
YSA_RS25900	COG1113	amino acid transport
YSA_RS25910	COG0113	porphobilinogen synthase activity
YSA_RS25925	COG0307	riboflavin synthase, alpha
YSA_RS25940	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
YSA_RS25950	COG1984	allophanate hydrolase subunit 2
YSA_RS25965	COG0579	oxidoreductase
YSA_RS25975	COG4106	trans-aconitate 2-methyltransferase activity
YSA_RS25985	COG0019	diaminopimelate decarboxylase activity
YSA_RS26015	COG0625	glutathione transferase activity
YSA_RS26030	COG0488	(ABC) transporter
YSA_RS26055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YSA_RS26090	COG2135	peptidase activity
YSA_RS26100	COG1858	cytochrome C peroxidase
YSA_RS26110	COG4191	Histidine kinase
YSA_RS26110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS26125	COG1477	protein flavinylation
YSA_RS26130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YSA_RS26150	COG0642	Histidine kinase
YSA_RS26155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YSA_RS26160	COG0697	spore germination
YSA_RS26220	COG0583	DNA-binding transcription factor activity
YSA_RS26245	COG0189	ligase activity
YSA_RS26285	COG0456	acetyltransferase
YSA_RS26285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
YSA_RS26315	COG0446	pyridine nucleotide-disulphide oxidoreductase
YSA_RS26315	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS26355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YSA_RS26360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YSA_RS26365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YSA_RS26370	COG0477	Major facilitator Superfamily
YSA_RS26430	COG2175	clavaminate synthase activity
YSA_RS26435	COG3246	L-lysine catabolic process to acetate
YSA_RS26440	COG2814	Major facilitator Superfamily
YSA_RS26485	COG1960	acyl-CoA dehydrogenase activity
YSA_RS26490	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS26500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YSA_RS26515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YSA_RS26610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YSA_RS26775	COG3179	chitinase
YSA_RS26805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YSA_RS26810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YSA_RS26815	COG4574	serine-type endopeptidase inhibitor activity
YSA_RS26820	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS26825	COG2610	gluconate transmembrane transporter activity
YSA_RS26830	COG3829	transcription factor binding
YSA_RS26830	COG3290	protein histidine kinase activity
YSA_RS26835	COG4239	(ABC) transporter, permease
YSA_RS26840	COG4174	ABC transporter (Permease)
YSA_RS26845	COG4166	transmembrane transport
YSA_RS26850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YSA_RS26855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YSA_RS26860	COG1881	PFAM PEBP family protein
YSA_RS27070	COG1473	amidohydrolase
YSA_RS27080	COG0154	amidase activity
YSA_RS27085	COG1414	Transcriptional regulator
YSA_RS27095	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS27100	COG1053	succinate dehydrogenase
YSA_RS27115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YSA_RS27120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YSA_RS27135	COG0587	DNA-directed DNA polymerase activity
YSA_RS27145	COG0656	L-ascorbic acid biosynthetic process
YSA_RS27155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
YSA_RS27165	COG2031	fatty acid transporter
YSA_RS27170	COG1396	sequence-specific DNA binding
YSA_RS27195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YSA_RS27240	COG1215	transferase activity, transferring glycosyl groups
YSA_RS27245	COG2990	Protein conserved in bacteria
YSA_RS27255	COG1215	transferase activity, transferring glycosyl groups
YSA_RS27270	COG0583	DNA-binding transcription factor activity
YSA_RS27275	COG1760	l-serine dehydratase
YSA_RS27285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YSA_RS27295	COG0174	glutamine synthetase
YSA_RS27310	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS27315	COG0583	DNA-binding transcription factor activity
YSA_RS27375	COG2814	Major facilitator Superfamily
YSA_RS27380	COG3485	protocatechuate 3,4-dioxygenase
YSA_RS27385	COG3135	benzoate transporter
YSA_RS27405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YSA_RS27410	COG1902	pentaerythritol trinitrate reductase activity
YSA_RS27415	COG0667	Aldo Keto reductase
YSA_RS27420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YSA_RS27425	COG2271	Major facilitator Superfamily
YSA_RS27430	COG3835	regulator
YSA_RS27435	COG1929	Belongs to the glycerate kinase type-1 family
YSA_RS27440	COG0583	DNA-binding transcription factor activity
YSA_RS27460	COG1999	signal sequence binding
YSA_RS27475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
YSA_RS27480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
YSA_RS27490	COG0402	S-adenosylhomocysteine deaminase activity
YSA_RS27495	COG2423	ornithine cyclodeaminase activity
YSA_RS27500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YSA_RS27530	COG4251	negative regulation of phosphorylation
YSA_RS27530	COG5001	Diguanylate cyclase
YSA_RS27530	COG3706	GGDEF domain
YSA_RS27530	COG2203	Gaf domain
YSA_RS27540	COG1285	pathogenesis
YSA_RS27550	COG0385	Bile acid
YSA_RS27555	COG2837	iron assimilation
YSA_RS27560	COG0667	Aldo Keto reductase
YSA_RS27585	COG2890	protein-(glutamine-N5) methyltransferase activity
YSA_RS27590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
YSA_RS27615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YSA_RS27645	COG0392	lysyltransferase activity
YSA_RS27650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YSA_RS27655	COG3568	Endonuclease Exonuclease Phosphatase
YSA_RS27685	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS27685	COG2030	dehydratase
YSA_RS27700	COG3162	membrane
YSA_RS27705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YSA_RS27710	COG2151	metal-sulfur cluster biosynthetic enzyme
YSA_RS27715	COG3396	Phenylacetate-CoA oxygenase
YSA_RS27720	COG3460	Phenylacetate-CoA oxygenase
YSA_RS27725	COG3396	Phenylacetate-CoA oxygenase
YSA_RS27735	COG0183	Belongs to the thiolase family
YSA_RS27740	COG2050	protein possibly involved in aromatic compounds catabolism
YSA_RS27745	COG1250	3-hydroxyacyl-CoA dehydrogenase
YSA_RS27750	COG1024	Enoyl-CoA hydratase
YSA_RS27755	COG1024	Enoyl-CoA hydratase
YSA_RS27765	COG3327	negative regulation of DNA-templated transcription, initiation
YSA_RS27775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YSA_RS27800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YSA_RS27840	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
YSA_RS27850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YSA_RS27870	COG0589	response to stress
YSA_RS27945	COG4974	Belongs to the 'phage' integrase family
YSA_RS27955	COG1473	amidohydrolase
YSA_RS27965	COG0583	DNA-binding transcription factor activity
YSA_RS27980	COG3384	dioxygenase
YSA_RS27990	COG2267	carboxylic ester hydrolase activity
YSA_RS27995	COG0778	Nitroreductase
YSA_RS28005	COG1942	4-Oxalocrotonate Tautomerase
YSA_RS28020	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS28025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YSA_RS28030	COG1082	Xylose isomerase domain protein TIM barrel
YSA_RS28045	COG0583	DNA-binding transcription factor activity
YSA_RS28065	COG4948	Mandelate Racemase Muconate Lactonizing
YSA_RS28070	COG4829	muconolactone delta-isomerase
YSA_RS28095	COG1733	regulation of RNA biosynthetic process
YSA_RS28135	COG0427	acetyl-CoA hydrolase
YSA_RS28145	COG2814	Major facilitator Superfamily
YSA_RS28150	COG1946	Acyl-CoA thioesterase
YSA_RS28155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
YSA_RS28165	COG0583	DNA-binding transcription factor activity
YSA_RS28190	COG2301	Belongs to the HpcH HpaI aldolase family
YSA_RS28195	COG1960	acyl-CoA dehydrogenase activity
YSA_RS28200	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
YSA_RS28210	COG2814	Major facilitator Superfamily
YSA_RS28220	COG1473	amidohydrolase
YSA_RS28265	COG0531	amino acid
YSA_RS28290	COG0861	Integral membrane protein TerC family
YSA_RS28310	COG0028	Belongs to the TPP enzyme family
YSA_RS28315	COG2080	2 iron, 2 sulfur cluster binding
YSA_RS28320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YSA_RS28325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YSA_RS28335	COG1058	Belongs to the CinA family
YSA_RS28335	COG1546	Belongs to the CinA family
YSA_RS28345	COG1063	alcohol dehydrogenase
YSA_RS28355	COG1028	Short-chain dehydrogenase reductase Sdr
YSA_RS28360	COG1538	Outer membrane efflux protein
YSA_RS28375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YSA_RS28380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YSA_RS28385	COG2814	Major facilitator Superfamily
YSA_RS28400	COG1469	GTP cyclohydrolase I activity
YSA_RS28415	COG1301	dicarboxylic acid transport
YSA_RS28425	COG0583	DNA-binding transcription factor activity
YSA_RS28455	COG3706	GGDEF domain
YSA_RS28460	COG0668	transmembrane transport
YSA_RS28465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YSA_RS28475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YSA_RS28500	COG2814	Major facilitator Superfamily
YSA_RS28510	COG0667	Aldo Keto reductase
YSA_RS28515	COG2205	protein histidine kinase activity
YSA_RS28520	COG0745	RESPONSE REGULATOR receiver
YSA_RS28535	COG2356	endonuclease I
YSA_RS28545	COG2271	Major facilitator Superfamily
YSA_RS28550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YSA_RS28560	COG1609	Transcriptional regulator
YSA_RS28620	COG2271	Major facilitator Superfamily
YSA_RS28635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YSA_RS28725	COG3813	Protein conserved in bacteria
YSA_RS28730	COG2197	response regulator
YSA_RS28735	COG2205	protein histidine kinase activity
YSA_RS28735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YSA_RS28750	COG1609	Transcriptional regulator
YSA_RS28755	COG3265	gluconokinase activity
YSA_RS28770	COG2204	response regulator
YSA_RS28775	COG2205	protein histidine kinase activity
YSA_RS28785	COG5002	protein histidine kinase activity
YSA_RS28790	COG1196	nuclear chromosome segregation
YSA_RS28790	COG0741	lytic transglycosylase activity
YSA_RS28790	COG0739	heme binding
YSA_RS28800	COG1459	type II secretion system
YSA_RS28805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS28830	COG0784	Response regulator, receiver
YSA_RS28830	COG4191	Histidine kinase
YSA_RS28850	COG2200	EAL domain
YSA_RS28860	COG1253	flavin adenine dinucleotide binding
YSA_RS28900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YSA_RS28910	COG2205	protein histidine kinase activity
YSA_RS28915	COG0745	RESPONSE REGULATOR receiver
YSA_RS28920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YSA_RS28930	COG0746	molybdenum cofactor guanylyltransferase activity
YSA_RS28935	COG0318	PFAM AMP-dependent synthetase and ligase
YSA_RS28960	COG1012	belongs to the aldehyde dehydrogenase family
YSA_RS28980	COG1132	(ABC) transporter
YSA_RS28985	COG3284	Transcriptional regulator
YSA_RS29015	COG2165	general secretion pathway protein
YSA_RS29020	COG2165	general secretion pathway protein
YSA_RS29025	COG4796	Type ii and iii secretion system protein
YSA_RS29050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YSA_RS29060	COG2204	response regulator
YSA_RS29100	COG1960	acyl-CoA dehydrogenase activity
YSA_RS29115	COG2384	SAM-dependent methyltransferase
YSA_RS29125	COG0826	peptidase U32
YSA_RS29130	COG2204	response regulator
YSA_RS29245	COG1110	DNA topoisomerase II activity
YSA_RS29315	COG4974	Belongs to the 'phage' integrase family
YSA_RS29430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YSA_RS29445	COG0305	Participates in initiation and elongation during chromosome replication
YSA_RS29495	COG3706	GGDEF domain
YSA_RS29495	COG4251	negative regulation of phosphorylation
YSA_RS29495	COG5001	Diguanylate cyclase
YSA_RS29495	COG2203	Gaf domain
YSA_RS29510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YSA_RS29640	COG1475	DNA binding
YSA_RS29645	COG1192	Involved in chromosome partitioning
YSA_RS29740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB