locus-tag	class	description
C1S65_RS00010	COG0592	DNA-directed DNA polymerase activity
C1S65_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1S65_RS00020	COG0187	DNA topoisomerase II activity
C1S65_RS00035	COG1252	NADH dehydrogenase
C1S65_RS00040	COG0730	response to heat
C1S65_RS00055	COG0477	Major facilitator Superfamily
C1S65_RS00065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1S65_RS00070	COG0751	glycine-tRNA ligase activity
C1S65_RS00075	COG0752	glycyl-tRNA synthetase alpha subunit
C1S65_RS00080	COG2818	Glycosylase
C1S65_RS00095	COG0569	domain protein
C1S65_RS00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1S65_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1S65_RS00110	COG0242	peptide deformylase activity
C1S65_RS00115	COG0758	DNA mediated transformation
C1S65_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
C1S65_RS00135	COG0408	coproporphyrinogen oxidase activity
C1S65_RS00140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1S65_RS00145	COG0659	secondary active sulfate transmembrane transporter activity
C1S65_RS00155	COG3119	arylsulfatase activity
C1S65_RS00170	COG0159	tryptophan synthase activity
C1S65_RS00175	COG0133	tryptophan synthase activity
C1S65_RS00190	COG3360	Dodecin
C1S65_RS00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS00205	COG1764	response to oxidative stress
C1S65_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1S65_RS00240	COG0339	signal peptide processing
C1S65_RS00245	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1S65_RS00260	COG0659	secondary active sulfate transmembrane transporter activity
C1S65_RS00285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1S65_RS00285	COG1565	acr, cog1565
C1S65_RS00290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1S65_RS00295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1S65_RS00320	COG1612	heme a metabolic process
C1S65_RS00325	COG0109	protoheme IX farnesyltransferase activity
C1S65_RS00340	COG2011	ABC-type metal ion transport system permease component
C1S65_RS00345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1S65_RS00360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S65_RS00365	COG1121	(ABC) transporter
C1S65_RS00370	COG0735	belongs to the Fur family
C1S65_RS00375	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1S65_RS00395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1S65_RS00410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S65_RS00425	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1S65_RS00430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C1S65_RS00435	COG5002	protein histidine kinase activity
C1S65_RS00440	COG2204	response regulator
C1S65_RS00465	COG1301	dicarboxylic acid transport
C1S65_RS00470	COG0700	Nucleoside recognition
C1S65_RS00485	COG1127	ABC transporter
C1S65_RS00490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S65_RS00505	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1S65_RS00510	COG0861	Integral membrane protein TerC family
C1S65_RS00515	COG2851	Citrate transporter
C1S65_RS00525	COG0708	Exodeoxyribonuclease III
C1S65_RS00530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1S65_RS00550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1S65_RS00555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S65_RS00560	COG0756	dUTP diphosphatase activity
C1S65_RS00565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1S65_RS00570	COG2003	Belongs to the UPF0758 family
C1S65_RS00575	COG0747	negative chemotaxis
C1S65_RS00580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1S65_RS00585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1S65_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS00610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S65_RS00615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS00625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS00640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS00645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1S65_RS00660	COG0427	acetyl-CoA hydrolase
C1S65_RS00665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1S65_RS00680	COG0534	Mate efflux family protein
C1S65_RS00685	COG0583	DNA-binding transcription factor activity
C1S65_RS00690	COG0672	)-iron permease
C1S65_RS00695	COG1671	Belongs to the UPF0178 family
C1S65_RS00700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1S65_RS00720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1S65_RS00740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1S65_RS00770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1S65_RS00790	COG3079	Belongs to the UPF0149 family
C1S65_RS00795	COG0006	proline dipeptidase activity
C1S65_RS00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S65_RS00810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S65_RS00820	COG1178	ABC-type Fe3 transport system permease component
C1S65_RS00825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S65_RS00830	COG0509	glycine decarboxylation via glycine cleavage system
C1S65_RS00835	COG5383	Protein conserved in bacteria
C1S65_RS00840	COG0583	DNA-binding transcription factor activity
C1S65_RS00845	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS00850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS00860	COG1335	isochorismatase
C1S65_RS00875	COG0583	DNA-binding transcription factor activity
C1S65_RS00880	COG1335	isochorismatase
C1S65_RS00890	COG3093	addiction module antidote protein HigA
C1S65_RS00910	COG0606	chelatase, subunit chli
C1S65_RS00915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S65_RS00930	COG1136	(ABC) transporter
C1S65_RS00930	COG0577	efflux transmembrane transporter activity
C1S65_RS00935	COG1136	(ABC) transporter
C1S65_RS00935	COG0577	efflux transmembrane transporter activity
C1S65_RS00975	COG0347	Belongs to the P(II) protein family
C1S65_RS00980	COG0004	ammonium transporteR
C1S65_RS00995	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C1S65_RS01005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1S65_RS01010	COG0019	diaminopimelate decarboxylase activity
C1S65_RS01020	COG1965	Belongs to the frataxin family
C1S65_RS01030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S65_RS01035	COG3072	Adenylate cyclase
C1S65_RS01050	COG0625	glutathione transferase activity
C1S65_RS01055	COG0165	Argininosuccinate lyase
C1S65_RS01065	COG0181	hydroxymethylbilane synthase activity
C1S65_RS01085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1S65_RS01110	COG0488	(ABC) transporter
C1S65_RS01120	COG1280	lysine exporter protein (LysE YggA)
C1S65_RS01135	COG0517	IMP dehydrogenase activity
C1S65_RS01160	COG2188	Transcriptional regulator
C1S65_RS01165	COG1053	succinate dehydrogenase
C1S65_RS01180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS01205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS01225	COG4771	TonB-dependent receptor
C1S65_RS01235	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS01240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S65_RS01250	COG0745	RESPONSE REGULATOR receiver
C1S65_RS01255	COG2199	diguanylate cyclase activity
C1S65_RS01270	COG2011	ABC-type metal ion transport system permease component
C1S65_RS01275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1S65_RS01305	COG1126	abc transporter atp-binding protein
C1S65_RS01310	COG0765	amino acid transport
C1S65_RS01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS01320	COG1045	serine acetyltransferase
C1S65_RS01325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S65_RS01330	COG2175	clavaminate synthase activity
C1S65_RS01335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS01340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C1S65_RS01345	COG4521	taurine ABC transporter
C1S65_RS01355	COG0450	alkyl hydroperoxide reductase
C1S65_RS01360	COG0431	NADPH-dependent FMN reductase
C1S65_RS01365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS01370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS01375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS01380	COG1116	anion transmembrane transporter activity
C1S65_RS01395	COG2918	glutathione biosynthetic process
C1S65_RS01405	COG2183	response to ionizing radiation
C1S65_RS01420	COG0189	ligase activity
C1S65_RS01425	COG4067	protein conserved in archaea
C1S65_RS01425	COG0189	ligase activity
C1S65_RS01430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1S65_RS01440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1S65_RS01445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1S65_RS01455	COG2197	response regulator
C1S65_RS01460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1S65_RS01475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1S65_RS01480	COG1652	LysM domain
C1S65_RS01485	COG1011	Hydrolase
C1S65_RS01490	COG0494	nUDIX hydrolase
C1S65_RS01495	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1S65_RS01525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1S65_RS01540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S65_RS01545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S65_RS01555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S65_RS01560	COG2957	Belongs to the agmatine deiminase family
C1S65_RS01580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1S65_RS01595	COG2223	nitrite transmembrane transporter activity
C1S65_RS01600	COG0131	Imidazoleglycerol-phosphate dehydratase
C1S65_RS01605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1S65_RS01615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1S65_RS01620	COG0107	imidazoleglycerol-phosphate synthase activity
C1S65_RS01625	COG4175	Glycine betaine
C1S65_RS01630	COG4176	ABC-type proline glycine betaine transport system permease component
C1S65_RS01640	COG1760	l-serine dehydratase
C1S65_RS01660	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1S65_RS01665	COG3246	L-lysine catabolic process to acetate
C1S65_RS01695	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS01695	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S65_RS01705	COG2181	nitrate reductase activity
C1S65_RS01705	COG0247	lactate metabolic process
C1S65_RS01710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1S65_RS01735	COG1017	nitric oxide dioxygenase activity
C1S65_RS01735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S65_RS01760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S65_RS01795	COG1063	alcohol dehydrogenase
C1S65_RS01810	COG0204	Acyl-transferase
C1S65_RS01815	COG0189	ligase activity
C1S65_RS01815	COG4067	protein conserved in archaea
C1S65_RS01820	COG0745	RESPONSE REGULATOR receiver
C1S65_RS01825	COG2205	protein histidine kinase activity
C1S65_RS01830	COG4452	Inner membrane protein CreD
C1S65_RS01840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S65_RS01860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1S65_RS01880	COG0438	transferase activity, transferring glycosyl groups
C1S65_RS01915	COG4774	siderophore transport
C1S65_RS01925	COG1595	DNA-templated transcription, initiation
C1S65_RS01930	COG2176	DNA-directed DNA polymerase activity
C1S65_RS01935	COG0516	GMP reductase activity
C1S65_RS01935	COG0517	IMP dehydrogenase activity
C1S65_RS01940	COG2204	response regulator
C1S65_RS01945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1S65_RS01960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1S65_RS01965	COG2005	Transcriptional regulator
C1S65_RS01965	COG3585	molybdate ion transport
C1S65_RS01970	COG1040	competence protein
C1S65_RS01975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1S65_RS01980	COG0156	8-amino-7-oxononanoate synthase activity
C1S65_RS02005	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS02010	COG3706	GGDEF domain
C1S65_RS02015	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS02020	COG0583	DNA-binding transcription factor activity
C1S65_RS02025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S65_RS02040	COG0535	radical SAM domain protein
C1S65_RS02050	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C1S65_RS02055	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1S65_RS02065	COG1025	Belongs to the peptidase M16 family
C1S65_RS02070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S65_RS02115	COG1690	Belongs to the RtcB family
C1S65_RS02120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1S65_RS02140	COG0358	DNA primase activity
C1S65_RS02145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1S65_RS02150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1S65_RS02155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1S65_RS02160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1S65_RS02170	COG0617	tRNA 3'-terminal CCA addition
C1S65_RS02175	COG2719	SpoVR family
C1S65_RS02180	COG2718	Belongs to the UPF0229 family
C1S65_RS02185	COG2766	serine protein kinase
C1S65_RS02190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1S65_RS02195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1S65_RS02200	COG2967	ApaG domain
C1S65_RS02205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1S65_RS02210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1S65_RS02215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S65_RS02220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1S65_RS02225	COG3178	'Phosphotransferase
C1S65_RS02230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1S65_RS02235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1S65_RS02245	COG4585	Histidine kinase
C1S65_RS02250	COG2197	response regulator
C1S65_RS02260	COG3842	ATPase activity
C1S65_RS02270	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1S65_RS02280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1S65_RS02285	COG0546	phosphoglycolate phosphatase activity
C1S65_RS02290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S65_RS02295	COG4625	pathogenesis
C1S65_RS02295	COG3240	lipase activity
C1S65_RS02300	COG0512	Glutamine amidotransferase of anthranilate synthase
C1S65_RS02305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1S65_RS02325	COG1765	OsmC-like protein
C1S65_RS02335	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C1S65_RS02340	COG0537	adenosine 5'-monophosphoramidase activity
C1S65_RS02345	COG0300	oxidoreductase activity
C1S65_RS02350	COG2070	2-Nitropropane dioxygenase
C1S65_RS02355	COG1981	membrane
C1S65_RS02360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1S65_RS02365	COG0316	Belongs to the HesB IscA family
C1S65_RS02370	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1S65_RS02375	COG0739	heme binding
C1S65_RS02385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1S65_RS02420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1S65_RS02445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1S65_RS02465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1S65_RS02470	COG0081	regulation of translation
C1S65_RS02475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1S65_RS02480	COG0222	ribosome binding
C1S65_RS02485	COG0085	RNA polymerase activity
C1S65_RS02490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1S65_RS02495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1S65_RS02500	COG0049	tRNA binding
C1S65_RS02505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S65_RS02510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1S65_RS02515	COG0051	transcription antitermination factor activity, RNA binding
C1S65_RS02520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1S65_RS02525	COG0088	Forms part of the polypeptide exit tunnel
C1S65_RS02530	COG0089	rRNA binding
C1S65_RS02535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1S65_RS02540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1S65_RS02545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1S65_RS02550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1S65_RS02555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1S65_RS02560	COG0255	Belongs to the universal ribosomal protein uL29 family
C1S65_RS02565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1S65_RS02570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1S65_RS02575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1S65_RS02580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1S65_RS02585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1S65_RS02590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1S65_RS02595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1S65_RS02600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1S65_RS02605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1S65_RS02610	COG1841	ribosomal large subunit assembly
C1S65_RS02615	COG0200	Binds to the 23S rRNA
C1S65_RS02625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1S65_RS02630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1S65_RS02635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1S65_RS02640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1S65_RS02645	COG0202	RNA polymerase activity
C1S65_RS02650	COG0203	ribosomal protein L17
C1S65_RS02655	COG0753	catalase activity
C1S65_RS02660	COG2193	ferroxidase activity
C1S65_RS02665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1S65_RS02670	COG2814	Major facilitator Superfamily
C1S65_RS02675	COG0629	single-stranded DNA binding
C1S65_RS02685	COG3383	formate dehydrogenase (NAD+) activity
C1S65_RS02685	COG0243	molybdopterin cofactor binding
C1S65_RS02690	COG3383	formate dehydrogenase (NAD+) activity
C1S65_RS02690	COG0243	molybdopterin cofactor binding
C1S65_RS02695	COG0437	4 iron, 4 sulfur cluster binding
C1S65_RS02700	COG2864	formate dehydrogenase
C1S65_RS02705	COG3058	Necessary for formate dehydrogenase activity
C1S65_RS02710	COG1921	L-seryl-tRNASec selenium transferase activity
C1S65_RS02715	COG3276	selenocysteine insertion sequence binding
C1S65_RS02725	COG0252	asparaginase activity
C1S65_RS02730	COG1115	amino acid carrier protein
C1S65_RS02770	COG2814	Major facilitator Superfamily
C1S65_RS02775	COG3047	cAMP biosynthetic process
C1S65_RS02790	COG1136	(ABC) transporter
C1S65_RS02790	COG0577	efflux transmembrane transporter activity
C1S65_RS02805	COG3118	belongs to the thioredoxin family
C1S65_RS02810	COG2264	protein methyltransferase activity
C1S65_RS02820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1S65_RS02825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S65_RS02825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1S65_RS02840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1S65_RS02845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1S65_RS02855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1S65_RS02865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S65_RS02875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1S65_RS02880	COG4206	TonB-dependent receptor
C1S65_RS02885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1S65_RS02890	COG0142	geranyltranstransferase activity
C1S65_RS02895	COG1722	exodeoxyribonuclease VII activity
C1S65_RS02915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S65_RS02925	COG4650	regulator
C1S65_RS02935	COG1690	Belongs to the RtcB family
C1S65_RS02940	COG3541	Predicted nucleotidyltransferase
C1S65_RS02945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1S65_RS02950	COG0583	DNA-binding transcription factor activity
C1S65_RS02960	COG0601	transmembrane transport
C1S65_RS02965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S65_RS02970	COG4172	Belongs to the ABC transporter superfamily
C1S65_RS02985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S65_RS03035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S65_RS03050	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1S65_RS03055	COG3228	Belongs to the MtfA family
C1S65_RS03060	COG0586	Pfam SNARE associated Golgi protein
C1S65_RS03070	COG0456	acetyltransferase
C1S65_RS03075	COG4302	ethanolamine ammonia-lyase activity
C1S65_RS03080	COG4303	Ethanolamine ammonia lyase large subunit
C1S65_RS03085	COG0531	amino acid
C1S65_RS03095	COG3284	Transcriptional regulator
C1S65_RS03100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1S65_RS03115	COG0702	epimerase
C1S65_RS03135	COG1346	cytolysis
C1S65_RS03145	COG0586	Pfam SNARE associated Golgi protein
C1S65_RS03150	COG2094	Belongs to the DNA glycosylase MPG family
C1S65_RS03155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1S65_RS03160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1S65_RS03170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1S65_RS03175	COG0768	penicillin binding
C1S65_RS03180	COG0772	Belongs to the SEDS family
C1S65_RS03185	COG2951	lytic endotransglycosylase activity
C1S65_RS03195	COG1686	Belongs to the peptidase S11 family
C1S65_RS03200	COG2921	Belongs to the UPF0250 family
C1S65_RS03205	COG0321	lipoyl(octanoyl) transferase activity
C1S65_RS03210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1S65_RS03215	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1S65_RS03220	COG2951	lytic endotransglycosylase activity
C1S65_RS03240	COG0495	leucyl-tRNA aminoacylation
C1S65_RS03255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1S65_RS03260	COG4535	Mg2 and Co2 transporter CorC
C1S65_RS03265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1S65_RS03270	COG1702	phosphate starvation-inducible protein PhoH
C1S65_RS03280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1S65_RS03285	COG0352	thiamine-phosphate diphosphorylase activity
C1S65_RS03290	COG0351	phosphomethylpyrimidine kinase
C1S65_RS03295	COG2205	protein histidine kinase activity
C1S65_RS03295	COG3437	response regulator, receiver
C1S65_RS03295	COG3850	Histidine kinase
C1S65_RS03295	COG4999	Histidine kinase
C1S65_RS03300	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS03305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1S65_RS03320	COG1522	sequence-specific DNA binding
C1S65_RS03340	COG1643	Atp-dependent helicase
C1S65_RS03350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S65_RS03365	COG3416	Protein conserved in bacteria
C1S65_RS03375	COG1522	sequence-specific DNA binding
C1S65_RS03380	COG0697	spore germination
C1S65_RS03385	COG0513	Belongs to the DEAD box helicase family
C1S65_RS03400	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1S65_RS03415	COG1946	Acyl-CoA thioesterase
C1S65_RS03420	COG0546	phosphoglycolate phosphatase activity
C1S65_RS03430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S65_RS03435	COG1120	ATPase activity
C1S65_RS03455	COG4589	Belongs to the CDS family
C1S65_RS03470	COG0671	phosphoesterase, PA-phosphatase related
C1S65_RS03470	COG2453	phosphatase
C1S65_RS03475	COG2267	carboxylic ester hydrolase activity
C1S65_RS03480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1S65_RS03495	COG1309	transcriptional regulator
C1S65_RS03500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1S65_RS03500	COG2010	Cytochrome c
C1S65_RS03505	COG2080	2 iron, 2 sulfur cluster binding
C1S65_RS03510	COG1846	Transcriptional regulator
C1S65_RS03515	COG2309	aminopeptidase activity
C1S65_RS03520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S65_RS03525	COG0596	Alpha beta hydrolase
C1S65_RS03530	COG3473	Maleate cis-trans isomerase
C1S65_RS03535	COG1335	isochorismatase
C1S65_RS03540	COG2271	Major facilitator Superfamily
C1S65_RS03550	COG0583	DNA-binding transcription factor activity
C1S65_RS03565	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S65_RS03570	COG0583	DNA-binding transcription factor activity
C1S65_RS03580	COG0840	transmembrane signaling receptor activity
C1S65_RS03585	COG0840	transmembrane signaling receptor activity
C1S65_RS03590	COG2321	neutral zinc metallopeptidase
C1S65_RS03595	COG3485	protocatechuate 3,4-dioxygenase
C1S65_RS03600	COG3485	protocatechuate 3,4-dioxygenase
C1S65_RS03605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1S65_RS03610	COG2252	PERMEase
C1S65_RS03630	COG1304	FMN binding
C1S65_RS03635	COG1620	l-lactate permease
C1S65_RS03645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1S65_RS03655	COG2914	Belongs to the UPF0125 (RnfH) family
C1S65_RS03660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S65_RS03665	COG0735	belongs to the Fur family
C1S65_RS03670	COG0497	DNA recombination
C1S65_RS03675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1S65_RS03680	COG0443	Heat shock 70 kDa protein
C1S65_RS03685	COG0484	heat shock protein binding
C1S65_RS03690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1S65_RS03695	COG0505	Belongs to the CarA family
C1S65_RS03700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1S65_RS03705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S65_RS03720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1S65_RS03730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1S65_RS03735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S65_RS03740	COG0149	triose-phosphate isomerase activity
C1S65_RS03745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1S65_RS03760	COG0779	Required for maturation of 30S ribosomal subunits
C1S65_RS03765	COG0195	Participates in both transcription termination and antitermination
C1S65_RS03770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1S65_RS03775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1S65_RS03780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1S65_RS03785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1S65_RS03795	COG1185	polyribonucleotide nucleotidyltransferase activity
C1S65_RS03800	COG2823	Periplasmic or secreted lipoprotein
C1S65_RS03815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S65_RS03820	COG0166	Belongs to the GPI family
C1S65_RS03825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1S65_RS03830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1S65_RS03845	COG2204	response regulator
C1S65_RS03850	COG4191	Histidine kinase
C1S65_RS03860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S65_RS03870	COG0436	Aminotransferase
C1S65_RS03875	COG1489	DNA binding
C1S65_RS03885	COG4558	Periplasmic binding protein
C1S65_RS03895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S65_RS03900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S65_RS03900	COG1648	precorrin-2 dehydrogenase activity
C1S65_RS03920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S65_RS03930	COG3098	single-species biofilm formation
C1S65_RS03935	COG0028	Belongs to the TPP enzyme family
C1S65_RS03945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1S65_RS03950	COG1183	phosphatidylcholine synthase activity
C1S65_RS03955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1S65_RS03960	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1S65_RS03990	COG2995	paraquat-inducible protein a
C1S65_RS03995	COG2995	paraquat-inducible protein a
C1S65_RS04000	COG3008	intermembrane lipid transfer
C1S65_RS04005	COG0268	Binds directly to 16S ribosomal RNA
C1S65_RS04020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1S65_RS04025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1S65_RS04030	COG1047	Peptidyl-prolyl cis-trans
C1S65_RS04035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1S65_RS04065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS04145	COG2336	PFAM SpoVT AbrB
C1S65_RS04155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S65_RS04160	COG2885	chlorophyll binding
C1S65_RS04165	COG0280	phosphate acetyltransferase
C1S65_RS04165	COG0857	belongs to the CobB CobQ family
C1S65_RS04180	COG0386	Belongs to the glutathione peroxidase family
C1S65_RS04210	COG0270	DNA (cytosine-5-)-methyltransferase activity
C1S65_RS04230	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C1S65_RS04235	COG0492	ferredoxin-NADP+ reductase activity
C1S65_RS04250	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1S65_RS04260	COG0840	transmembrane signaling receptor activity
C1S65_RS04295	COG2223	nitrite transmembrane transporter activity
C1S65_RS04310	COG3712	iron ion homeostasis
C1S65_RS04315	COG1595	DNA-templated transcription, initiation
C1S65_RS04325	COG2169	Transcriptional regulator
C1S65_RS04325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1S65_RS04330	COG1511	domain protein
C1S65_RS04330	COG3264	Mechanosensitive ion channel
C1S65_RS04370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1S65_RS04375	COG1522	sequence-specific DNA binding
C1S65_RS04385	COG1309	transcriptional regulator
C1S65_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS04415	COG0012	GTP binding
C1S65_RS04420	COG0193	aminoacyl-tRNA hydrolase activity
C1S65_RS04425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1S65_RS04430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1S65_RS04440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1S65_RS04445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1S65_RS04455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1S65_RS04460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1S65_RS04470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1S65_RS04475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1S65_RS04490	COG0415	Belongs to the DNA photolyase family
C1S65_RS04495	COG0789	Transcriptional regulator
C1S65_RS04500	COG3272	Protein of unknown function (DUF1722)
C1S65_RS04505	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C1S65_RS04510	COG1090	epimerase
C1S65_RS04515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1S65_RS04525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1S65_RS04530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1S65_RS04550	COG0579	oxidoreductase
C1S65_RS04590	COG2135	peptidase activity
C1S65_RS04595	COG0840	transmembrane signaling receptor activity
C1S65_RS04605	COG2119	membrane
C1S65_RS04610	COG2813	Specifically methylates the guanine in position
C1S65_RS04615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S65_RS04620	COG0318	PFAM AMP-dependent synthetase and ligase
C1S65_RS04640	COG0542	response to heat
C1S65_RS04660	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C1S65_RS04665	COG1252	NADH dehydrogenase
C1S65_RS04685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1S65_RS04690	COG0237	dephospho-CoA kinase activity
C1S65_RS04715	COG0582	viral genome integration into host DNA
C1S65_RS04780	COG3059	membrane
C1S65_RS04785	COG4977	sequence-specific DNA binding
C1S65_RS04785	COG1917	Cupin 2, conserved barrel domain protein
C1S65_RS04805	COG1522	sequence-specific DNA binding
C1S65_RS04820	COG0583	DNA-binding transcription factor activity
C1S65_RS04835	COG1063	alcohol dehydrogenase
C1S65_RS04845	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C1S65_RS04850	COG4221	oxidoreductase activity
C1S65_RS04855	COG4977	sequence-specific DNA binding
C1S65_RS04860	COG1309	transcriptional regulator
C1S65_RS04865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S65_RS04870	COG2814	Major facilitator Superfamily
C1S65_RS04880	COG1733	regulation of RNA biosynthetic process
C1S65_RS04890	COG2205	protein histidine kinase activity
C1S65_RS04930	COG0477	Major facilitator Superfamily
C1S65_RS04935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S65_RS04945	COG1764	response to oxidative stress
C1S65_RS04970	COG2957	Belongs to the agmatine deiminase family
C1S65_RS04985	COG2957	Belongs to the agmatine deiminase family
C1S65_RS04995	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1S65_RS05035	COG0789	Transcriptional regulator
C1S65_RS05045	COG1366	Belongs to the anti-sigma-factor antagonist family
C1S65_RS05055	COG0583	DNA-binding transcription factor activity
C1S65_RS05060	COG1380	Effector of murein hydrolase LrgA
C1S65_RS05065	COG1346	cytolysis
C1S65_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS05085	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1S65_RS05110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1S65_RS05135	COG1595	DNA-templated transcription, initiation
C1S65_RS05140	COG3712	iron ion homeostasis
C1S65_RS05155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS05170	COG4772	TonB-dependent receptor
C1S65_RS05175	COG3712	iron ion homeostasis
C1S65_RS05180	COG1595	DNA-templated transcription, initiation
C1S65_RS05220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C1S65_RS05235	COG4608	Belongs to the ABC transporter superfamily
C1S65_RS05240	COG0444	Belongs to the ABC transporter superfamily
C1S65_RS05245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S65_RS05250	COG0601	transmembrane transport
C1S65_RS05255	COG0747	negative chemotaxis
C1S65_RS05265	COG0747	negative chemotaxis
C1S65_RS05270	COG0747	negative chemotaxis
C1S65_RS05285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C1S65_RS05305	COG1113	amino acid transport
C1S65_RS05310	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S65_RS05325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1S65_RS05330	COG0154	amidase activity
C1S65_RS05335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1S65_RS05340	COG1077	Cell shape determining protein MreB Mrl
C1S65_RS05345	COG1792	Involved in formation and maintenance of cell shape
C1S65_RS05355	COG0424	maF-like protein
C1S65_RS05370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S65_RS05375	COG0312	modulator of DNA gyrase
C1S65_RS05380	COG3028	Belongs to the UPF0307 family
C1S65_RS05385	COG0312	modulator of DNA gyrase
C1S65_RS05415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S65_RS05420	COG1660	Displays ATPase and GTPase activities
C1S65_RS05430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1S65_RS05435	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1S65_RS05440	COG1137	ATPase activity
C1S65_RS05445	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1S65_RS05455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1S65_RS05465	COG1127	ABC transporter
C1S65_RS05470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S65_RS05475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S65_RS05495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1S65_RS05500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1S65_RS05505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1S65_RS05510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1S65_RS05515	COG2186	Transcriptional regulator
C1S65_RS05520	COG2807	transmembrane transport
C1S65_RS05535	COG2827	Endonuclease containing a URI domain
C1S65_RS05540	COG3081	Nucleoid-associated protein
C1S65_RS05550	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1S65_RS05555	COG0525	valine-tRNA ligase activity
C1S65_RS05570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1S65_RS05580	COG0795	lipopolysaccharide-transporting ATPase activity
C1S65_RS05585	COG0795	lipopolysaccharide-transporting ATPase activity
C1S65_RS05595	COG1278	Cold shock
C1S65_RS05605	COG1760	l-serine dehydratase
C1S65_RS05610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S65_RS05610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S65_RS05615	COG0509	glycine decarboxylation via glycine cleavage system
C1S65_RS05640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1S65_RS05645	COG2235	arginine
C1S65_RS05665	COG2832	Protein of unknown function (DUF454)
C1S65_RS05675	COG4771	TonB-dependent receptor
C1S65_RS05725	COG1175	transmembrane transport
C1S65_RS05730	COG0395	ABC-type sugar transport system, permease component
C1S65_RS05735	COG3842	ATPase activity
C1S65_RS05745	COG0676	glucose-6-phosphate 1-epimerase activity
C1S65_RS05750	COG1737	Transcriptional regulator
C1S65_RS05765	COG0800	Aldolase
C1S65_RS05770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S65_RS05775	COG0739	heme binding
C1S65_RS05780	COG1570	exodeoxyribonuclease VII activity
C1S65_RS05800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1S65_RS05800	COG0519	Catalyzes the synthesis of GMP from XMP
C1S65_RS05815	COG0745	RESPONSE REGULATOR receiver
C1S65_RS05830	COG0590	tRNA wobble adenosine to inosine editing
C1S65_RS05835	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1S65_RS05840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1S65_RS05840	COG0047	phosphoribosylformylglycinamidine synthase activity
C1S65_RS05845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1S65_RS05860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S65_RS05865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S65_RS05960	COG3034	peptidoglycan biosynthetic process
C1S65_RS05970	COG0494	nUDIX hydrolase
C1S65_RS05990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1S65_RS05995	COG0477	Major facilitator Superfamily
C1S65_RS06000	COG4536	flavin adenine dinucleotide binding
C1S65_RS06010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1S65_RS06015	COG0228	four-way junction DNA binding
C1S65_RS06020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1S65_RS06025	COG0336	Belongs to the RNA methyltransferase TrmD family
C1S65_RS06030	COG0335	large ribosomal subunit rRNA binding
C1S65_RS06035	COG1607	acyl-coa hydrolase
C1S65_RS06040	COG4974	Belongs to the 'phage' integrase family
C1S65_RS06045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1S65_RS06075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S65_RS06090	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS06095	COG2979	Protein of unknown function (DUF533)
C1S65_RS06100	COG0840	transmembrane signaling receptor activity
C1S65_RS06110	COG0457	Tetratricopeptide repeat
C1S65_RS06110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1S65_RS06125	COG2201	protein-glutamate methylesterase activity
C1S65_RS06130	COG5001	Diguanylate cyclase
C1S65_RS06130	COG4251	negative regulation of phosphorylation
C1S65_RS06130	COG3706	GGDEF domain
C1S65_RS06130	COG2203	Gaf domain
C1S65_RS06145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1S65_RS06175	COG2885	chlorophyll binding
C1S65_RS06190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1S65_RS06195	COG0563	adenylate kinase activity
C1S65_RS06230	COG0742	ribosomal rna small subunit methyltransferase
C1S65_RS06240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS06265	COG1024	Enoyl-CoA hydratase
C1S65_RS06270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1S65_RS06315	COG0354	folic acid binding
C1S65_RS06320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1S65_RS06350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S65_RS06355	COG0481	GTPase activity
C1S65_RS06360	COG0681	Belongs to the peptidase S26 family
C1S65_RS06365	COG0571	ribonuclease III activity
C1S65_RS06370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1S65_RS06375	COG1381	Involved in DNA repair and RecF pathway recombination
C1S65_RS06380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1S65_RS06385	COG0642	Histidine kinase
C1S65_RS06400	COG0500	methyltransferase
C1S65_RS06405	COG2226	methyltransferase
C1S65_RS06425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1S65_RS06445	COG4206	TonB-dependent receptor
C1S65_RS06450	COG4628	conserved protein (DUF2132)
C1S65_RS06460	COG2375	cellular response to nickel ion
C1S65_RS06465	COG1695	Transcriptional regulator
C1S65_RS06475	COG0069	glutamate synthase activity
C1S65_RS06480	COG0254	rRNA binding
C1S65_RS06485	COG1201	RNA secondary structure unwinding
C1S65_RS06490	COG0494	nUDIX hydrolase
C1S65_RS06495	COG0583	DNA-binding transcription factor activity
C1S65_RS06500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S65_RS06515	COG1126	abc transporter atp-binding protein
C1S65_RS06520	COG0765	amino acid transport
C1S65_RS06525	COG0765	amino acid transport
C1S65_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS06545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1S65_RS06555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1S65_RS06560	COG3842	ATPase activity
C1S65_RS06565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1S65_RS06570	COG0243	molybdopterin cofactor binding
C1S65_RS06575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1S65_RS06595	COG0450	alkyl hydroperoxide reductase
C1S65_RS06600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1S65_RS06605	COG0418	dihydroorotase activity
C1S65_RS06615	COG0137	argininosuccinate synthase activity
C1S65_RS06625	COG2197	response regulator
C1S65_RS06630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1S65_RS06635	COG4660	Part of a membrane complex involved in electron transport
C1S65_RS06640	COG4659	FMN binding
C1S65_RS06650	COG2878	Part of a membrane complex involved in electron transport
C1S65_RS06655	COG4657	Part of a membrane complex involved in electron transport
C1S65_RS06660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S65_RS06660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S65_RS06665	COG0489	protein tyrosine kinase activity
C1S65_RS06670	COG1278	Cold shock
C1S65_RS06675	COG0717	Belongs to the dCTP deaminase family
C1S65_RS06690	COG1201	RNA secondary structure unwinding
C1S65_RS06700	COG1793	dna ligase
C1S65_RS06710	COG2366	antibiotic biosynthetic process
C1S65_RS06715	COG0653	protein targeting
C1S65_RS06725	COG3012	SEC-C Motif Domain Protein
C1S65_RS06760	COG1199	ATP-dependent helicase activity
C1S65_RS06780	COG0259	pyridoxamine-phosphate oxidase activity
C1S65_RS06790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1S65_RS06805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C1S65_RS06855	COG2084	Dehydrogenase
C1S65_RS06865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1S65_RS06880	COG1289	transmembrane transporter activity
C1S65_RS06895	COG4221	oxidoreductase activity
C1S65_RS06915	COG3706	GGDEF domain
C1S65_RS06925	COG2116	formate transmembrane transporter activity
C1S65_RS06965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1S65_RS06970	COG2706	6-phosphogluconolactonase activity
C1S65_RS06975	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1S65_RS06985	COG3012	SEC-C Motif Domain Protein
C1S65_RS06985	COG3318	Belongs to the UPF0149 family
C1S65_RS06990	COG0625	glutathione transferase activity
C1S65_RS07020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1S65_RS07030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S65_RS07045	COG2814	Major facilitator Superfamily
C1S65_RS07050	COG1309	transcriptional regulator
C1S65_RS07075	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C1S65_RS07080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1S65_RS07085	COG0583	DNA-binding transcription factor activity
C1S65_RS07095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1S65_RS07100	COG0583	DNA-binding transcription factor activity
C1S65_RS07120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S65_RS07125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1S65_RS07125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S65_RS07140	COG2205	protein histidine kinase activity
C1S65_RS07170	COG1301	dicarboxylic acid transport
C1S65_RS07175	COG3091	SprT-like family
C1S65_RS07185	COG0037	tRNA processing
C1S65_RS07205	COG1393	Belongs to the ArsC family
C1S65_RS07225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S65_RS07230	COG2205	protein histidine kinase activity
C1S65_RS07230	COG5002	protein histidine kinase activity
C1S65_RS07230	COG0784	Response regulator, receiver
C1S65_RS07250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1S65_RS07255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S65_RS07260	COG3956	TIGRFAM MazG family protein
C1S65_RS07265	COG3122	Protein conserved in bacteria
C1S65_RS07280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1S65_RS07285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1S65_RS07295	COG0628	permease
C1S65_RS07300	COG0579	oxidoreductase
C1S65_RS07330	COG0531	amino acid
C1S65_RS07360	COG4789	Type iii secretion
C1S65_RS07365	COG4964	Belongs to the GSP D family
C1S65_RS07395	COG4669	(LipO)protein
C1S65_RS07420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1S65_RS07425	COG4790	Type iii secretion
C1S65_RS07435	COG4791	protein targeting
C1S65_RS07440	COG4792	protein secretion
C1S65_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS07480	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1S65_RS07485	COG3781	membrane
C1S65_RS07490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1S65_RS07495	COG1522	sequence-specific DNA binding
C1S65_RS07500	COG0626	cystathionine gamma-synthase activity
C1S65_RS07510	COG2194	sulfuric ester hydrolase activity
C1S65_RS07520	COG3100	YcgL domain-containing protein
C1S65_RS07535	COG2983	Belongs to the UPF0260 family
C1S65_RS07580	COG0121	glutamine amidotransferase
C1S65_RS07595	COG2814	Major facilitator Superfamily
C1S65_RS07600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1S65_RS07605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1S65_RS07610	COG1984	allophanate hydrolase subunit 2
C1S65_RS07620	COG0542	response to heat
C1S65_RS07630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1S65_RS07650	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C1S65_RS07670	COG3420	alginic acid biosynthetic process
C1S65_RS07680	COG1295	ribonuclease BN
C1S65_RS07685	COG0242	peptide deformylase activity
C1S65_RS07700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS07715	COG3795	YCII-related domain
C1S65_RS07720	COG4941	Belongs to the sigma-70 factor family
C1S65_RS07725	COG2030	dehydratase
C1S65_RS07730	COG2267	carboxylic ester hydrolase activity
C1S65_RS07735	COG0318	PFAM AMP-dependent synthetase and ligase
C1S65_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
C1S65_RS07745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS07750	COG0174	glutamine synthetase
C1S65_RS07760	COG1643	Atp-dependent helicase
C1S65_RS07770	COG2188	Transcriptional regulator
C1S65_RS07780	COG1132	(ABC) transporter
C1S65_RS07790	COG2267	carboxylic ester hydrolase activity
C1S65_RS07805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1S65_RS07810	COG0583	DNA-binding transcription factor activity
C1S65_RS07830	COG0679	Auxin Efflux Carrier
C1S65_RS07850	COG0668	transmembrane transport
C1S65_RS07855	COG0513	Belongs to the DEAD box helicase family
C1S65_RS07875	COG3210	domain, Protein
C1S65_RS07915	COG0697	spore germination
C1S65_RS07940	COG0583	DNA-binding transcription factor activity
C1S65_RS07945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S65_RS07960	COG0840	transmembrane signaling receptor activity
C1S65_RS07975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS07995	COG2832	Protein of unknown function (DUF454)
C1S65_RS08005	COG0514	ATP-dependent DNA helicase (RecQ)
C1S65_RS08015	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1S65_RS08050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1S65_RS08055	COG0778	Nitroreductase
C1S65_RS08060	COG0642	Histidine kinase
C1S65_RS08070	COG3214	Protein conserved in bacteria
C1S65_RS08075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1S65_RS08090	COG3384	dioxygenase
C1S65_RS08095	COG0500	methyltransferase
C1S65_RS08100	COG0501	Belongs to the peptidase M48B family
C1S65_RS08105	COG0436	Aminotransferase
C1S65_RS08110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S65_RS08115	COG0386	Belongs to the glutathione peroxidase family
C1S65_RS08120	COG5002	protein histidine kinase activity
C1S65_RS08120	COG2205	protein histidine kinase activity
C1S65_RS08120	COG0784	Response regulator, receiver
C1S65_RS08130	COG1956	GAF domain-containing protein
C1S65_RS08160	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS08165	COG0625	glutathione transferase activity
C1S65_RS08170	COG1131	(ABC) transporter
C1S65_RS08175	COG0842	Transport permease protein
C1S65_RS08190	COG0811	peptide transport
C1S65_RS08195	COG0848	biopolymer transport protein
C1S65_RS08200	COG1663	tetraacyldisaccharide 4'-kinase activity
C1S65_RS08205	COG2835	tetraacyldisaccharide 4'-kinase activity
C1S65_RS08210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1S65_RS08215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S65_RS08220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1S65_RS08225	COG1530	ribonuclease E activity
C1S65_RS08240	COG0546	phosphoglycolate phosphatase activity
C1S65_RS08245	COG0616	signal peptide processing
C1S65_RS08245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1S65_RS08250	COG0424	maF-like protein
C1S65_RS08260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1S65_RS08265	COG0416	fatty acid biosynthetic process
C1S65_RS08280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S65_RS08285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1S65_RS08295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1S65_RS08300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1S65_RS08310	COG0084	hydrolase, TatD family'
C1S65_RS08345	COG0556	nucleotide-excision repair
C1S65_RS08360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S65_RS08410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S65_RS08430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1S65_RS08435	COG0066	3-isopropylmalate dehydratase activity
C1S65_RS08440	COG2226	methyltransferase
C1S65_RS08445	COG0473	3-isopropylmalate dehydrogenase activity
C1S65_RS08470	COG0135	phosphoribosylanthranilate isomerase activity
C1S65_RS08475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1S65_RS08480	COG0285	dihydrofolate synthase activity
C1S65_RS08490	COG1286	toxin biosynthetic process
C1S65_RS08545	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S65_RS08545	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS08565	COG3038	cytochrome b561
C1S65_RS08575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1S65_RS08580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1S65_RS08590	COG3139	Protein of unknown function (DUF1315)
C1S65_RS08600	COG0308	aminopeptidase N
C1S65_RS08620	COG2706	6-phosphogluconolactonase activity
C1S65_RS08640	COG0420	3'-5' exonuclease activity
C1S65_RS08670	COG0714	Associated with various cellular activities
C1S65_RS08675	COG2252	PERMEase
C1S65_RS08685	COG0402	S-adenosylhomocysteine deaminase activity
C1S65_RS08715	COG3115	cell septum assembly
C1S65_RS08720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1S65_RS08760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1S65_RS08765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1S65_RS08770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1S65_RS08780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S65_RS08785	COG4413	Urea transporter
C1S65_RS08795	COG0469	pyruvate kinase activity
C1S65_RS08805	COG2084	Dehydrogenase
C1S65_RS08810	COG3622	Belongs to the hyi family
C1S65_RS08815	COG3960	tartronate-semialdehyde synthase activity
C1S65_RS08825	COG1309	transcriptional regulator
C1S65_RS08830	COG2354	Protein conserved in bacteria
C1S65_RS08845	COG2233	PERMEase
C1S65_RS08855	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C1S65_RS08875	COG2831	hemolysin activation secretion protein
C1S65_RS08880	COG3210	domain, Protein
C1S65_RS08905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1S65_RS08920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S65_RS08935	COG0668	transmembrane transport
C1S65_RS08955	COG2223	nitrite transmembrane transporter activity
C1S65_RS08960	COG3707	response regulator
C1S65_RS08965	COG1116	anion transmembrane transporter activity
C1S65_RS08965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS08970	COG0167	dihydroorotate dehydrogenase activity
C1S65_RS08975	COG3130	regulation of translation
C1S65_RS08980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1S65_RS08980	COG0116	Belongs to the methyltransferase superfamily
C1S65_RS08990	COG2027	D-alanyl-D-alanine carboxypeptidase
C1S65_RS08995	COG3171	Protein conserved in bacteria
C1S65_RS09000	COG2205	protein histidine kinase activity
C1S65_RS09000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS09005	COG2197	response regulator
C1S65_RS09015	COG1192	Involved in chromosome partitioning
C1S65_RS09195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1S65_RS09250	COG4575	ribosome binding
C1S65_RS09255	COG0004	ammonium transporteR
C1S65_RS09280	COG0840	transmembrane signaling receptor activity
C1S65_RS09295	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1S65_RS09300	COG0425	Belongs to the sulfur carrier protein TusA family
C1S65_RS09305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S65_RS09325	COG0730	response to heat
C1S65_RS09330	COG0840	transmembrane signaling receptor activity
C1S65_RS09335	COG0583	DNA-binding transcription factor activity
C1S65_RS09350	COG1214	PFAM Peptidase M22, glycoprotease
C1S65_RS09350	COG0456	acetyltransferase
C1S65_RS09360	COG4977	sequence-specific DNA binding
C1S65_RS09370	COG2186	Transcriptional regulator
C1S65_RS09385	COG4598	ABC transporter
C1S65_RS09415	COG1538	Outer membrane efflux protein
C1S65_RS09420	COG1136	(ABC) transporter
C1S65_RS09420	COG0577	efflux transmembrane transporter activity
C1S65_RS09425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS09435	COG2205	protein histidine kinase activity
C1S65_RS09435	COG2198	Histidine kinase
C1S65_RS09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS09435	COG0784	Response regulator, receiver
C1S65_RS09450	COG1132	(ABC) transporter
C1S65_RS09465	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1S65_RS09475	COG0438	transferase activity, transferring glycosyl groups
C1S65_RS09480	COG1597	lipid kinase activity
C1S65_RS09485	COG2197	response regulator
C1S65_RS09490	COG3851	Histidine kinase
C1S65_RS09500	COG0784	Response regulator, receiver
C1S65_RS09500	COG0835	chemotaxis
C1S65_RS09515	COG0642	Histidine kinase
C1S65_RS09525	COG2423	ornithine cyclodeaminase activity
C1S65_RS09535	COG3284	Transcriptional regulator
C1S65_RS09540	COG3842	ATPase activity
C1S65_RS09545	COG3842	ATPase activity
C1S65_RS09555	COG0395	ABC-type sugar transport system, permease component
C1S65_RS09570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1S65_RS09605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S65_RS09630	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1S65_RS09635	COG0740	serine-type endopeptidase activity
C1S65_RS09640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1S65_RS09645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1S65_RS09655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S65_RS09695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1S65_RS09700	COG2259	Doxx family
C1S65_RS09710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S65_RS09720	COG2814	Major facilitator Superfamily
C1S65_RS09725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1S65_RS09730	COG4181	ATPase activity
C1S65_RS09770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1S65_RS09775	COG0589	response to stress
C1S65_RS09805	COG0189	ligase activity
C1S65_RS09805	COG4067	protein conserved in archaea
C1S65_RS09810	COG1802	Transcriptional regulator
C1S65_RS09820	COG0372	Belongs to the citrate synthase family
C1S65_RS09835	COG2828	Protein conserved in bacteria
C1S65_RS09860	COG0720	synthase
C1S65_RS09890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1S65_RS09890	COG0517	IMP dehydrogenase activity
C1S65_RS09890	COG0617	tRNA 3'-terminal CCA addition
C1S65_RS09910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1S65_RS09930	COG0745	RESPONSE REGULATOR receiver
C1S65_RS09935	COG4251	negative regulation of phosphorylation
C1S65_RS09975	COG2866	Carboxypeptidase
C1S65_RS10005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S65_RS10010	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS10015	COG0318	PFAM AMP-dependent synthetase and ligase
C1S65_RS10035	COG0366	Alpha amylase catalytic
C1S65_RS10040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1S65_RS10085	COG1640	4-alpha-glucanotransferase
C1S65_RS10090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1S65_RS10095	COG0297	glycogen (starch) synthase activity
C1S65_RS10100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C1S65_RS10105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1S65_RS10125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS10130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS10135	COG0625	glutathione transferase activity
C1S65_RS10145	COG2066	Belongs to the glutaminase family
C1S65_RS10155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C1S65_RS10155	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C1S65_RS10160	COG2153	protein acetylation
C1S65_RS10165	COG2850	peptidyl-arginine hydroxylation
C1S65_RS10175	COG2915	High frequency lysogenization protein hflD homolog
C1S65_RS10180	COG0482	sulfurtransferase activity
C1S65_RS10200	COG1278	Cold shock
C1S65_RS10205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1S65_RS10210	COG0542	response to heat
C1S65_RS10215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1S65_RS10220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1S65_RS10225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1S65_RS10230	COG1674	ftsk spoiiie
C1S65_RS10235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1S65_RS10240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1S65_RS10245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1S65_RS10250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1S65_RS10255	COG1648	precorrin-2 dehydrogenase activity
C1S65_RS10255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S65_RS10260	COG0435	Glutathione S-transferase
C1S65_RS10265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1S65_RS10270	COG2920	part of a sulfur-relay system
C1S65_RS10290	COG2233	PERMEase
C1S65_RS10340	COG1404	Belongs to the peptidase S8 family
C1S65_RS10345	COG0464	growth
C1S65_RS10355	COG0596	Alpha beta hydrolase
C1S65_RS10385	COG2199	diguanylate cyclase activity
C1S65_RS10390	COG0490	domain, Protein
C1S65_RS10390	COG0471	metal ion transport
C1S65_RS10395	COG3387	PFAM Glycoside hydrolase 15-related
C1S65_RS10400	COG1007	ATP synthesis coupled electron transport
C1S65_RS10415	COG0713	ATP synthesis coupled electron transport
C1S65_RS10425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S65_RS10430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1S65_RS10435	COG1034	ATP synthesis coupled electron transport
C1S65_RS10450	COG0649	NAD binding
C1S65_RS10450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S65_RS10455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S65_RS10460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S65_RS10480	COG0659	secondary active sulfate transmembrane transporter activity
C1S65_RS10485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S65_RS10510	COG0583	DNA-binding transcription factor activity
C1S65_RS10515	COG1113	amino acid transport
C1S65_RS10525	COG0625	glutathione transferase activity
C1S65_RS10530	COG3189	MarR family transcriptional regulator
C1S65_RS10550	COG0322	excinuclease ABC activity
C1S65_RS10595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1S65_RS10605	COG0668	transmembrane transport
C1S65_RS10610	COG1595	DNA-templated transcription, initiation
C1S65_RS10615	COG3712	iron ion homeostasis
C1S65_RS10635	COG2072	flavoprotein involved in K transport
C1S65_RS10655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C1S65_RS10665	COG2031	fatty acid transporter
C1S65_RS10695	COG1595	DNA-templated transcription, initiation
C1S65_RS10710	COG1124	(ABC) transporter
C1S65_RS10715	COG0444	Belongs to the ABC transporter superfamily
C1S65_RS10720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S65_RS10725	COG0601	transmembrane transport
C1S65_RS10730	COG0747	negative chemotaxis
C1S65_RS10735	COG0864	Transcriptional regulator
C1S65_RS10750	COG4221	oxidoreductase activity
C1S65_RS10755	COG2207	Transcriptional regulator
C1S65_RS10765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1S65_RS10770	COG1121	(ABC) transporter
C1S65_RS10820	COG0657	acetylesterase activity
C1S65_RS10830	COG0583	DNA-binding transcription factor activity
C1S65_RS10835	COG1301	dicarboxylic acid transport
C1S65_RS10845	COG0235	Class ii aldolase
C1S65_RS10850	COG0583	DNA-binding transcription factor activity
C1S65_RS10860	COG0789	Transcriptional regulator
C1S65_RS10865	COG2207	Transcriptional regulator
C1S65_RS10885	COG0583	DNA-binding transcription factor activity
C1S65_RS10915	COG2204	response regulator
C1S65_RS10920	COG3119	arylsulfatase activity
C1S65_RS10965	COG0840	transmembrane signaling receptor activity
C1S65_RS10970	COG1968	undecaprenyl-diphosphatase activity
C1S65_RS10985	COG0583	DNA-binding transcription factor activity
C1S65_RS10990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1S65_RS11010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1S65_RS11015	COG1454	alcohol dehydrogenase
C1S65_RS11065	COG0726	polysaccharide deacetylase
C1S65_RS11075	COG1215	transferase activity, transferring glycosyl groups
C1S65_RS11130	COG2271	Major facilitator Superfamily
C1S65_RS11135	COG3835	regulator
C1S65_RS11140	COG1929	Belongs to the glycerate kinase type-1 family
C1S65_RS11150	COG3040	lipid binding
C1S65_RS11165	COG1024	Enoyl-CoA hydratase
C1S65_RS11170	COG1309	transcriptional regulator
C1S65_RS11190	COG0833	amino acid
C1S65_RS11195	COG1024	Enoyl-CoA hydratase
C1S65_RS11200	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS11220	COG1959	2 iron, 2 sulfur cluster binding
C1S65_RS11230	COG0601	transmembrane transport
C1S65_RS11235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S65_RS11240	COG4172	Belongs to the ABC transporter superfamily
C1S65_RS11245	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S65_RS11250	COG0768	penicillin binding
C1S65_RS11255	COG1132	(ABC) transporter
C1S65_RS11275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1S65_RS11285	COG0581	inorganic phosphate transmembrane transporter activity
C1S65_RS11290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S65_RS11315	COG0531	amino acid
C1S65_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS11360	COG2264	protein methyltransferase activity
C1S65_RS11365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1S65_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS11440	COG0392	lysyltransferase activity
C1S65_RS11445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S65_RS11450	COG3568	Endonuclease Exonuclease Phosphatase
C1S65_RS11490	COG3046	protein related to deoxyribodipyrimidine photolyase
C1S65_RS11505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S65_RS11530	COG1366	Belongs to the anti-sigma-factor antagonist family
C1S65_RS11535	COG0789	Transcriptional regulator
C1S65_RS11550	COG1063	alcohol dehydrogenase
C1S65_RS11570	COG5295	Hep Hag repeat protein
C1S65_RS11580	COG2197	response regulator
C1S65_RS11585	COG2198	Histidine kinase
C1S65_RS11585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS11585	COG2205	protein histidine kinase activity
C1S65_RS11585	COG0784	Response regulator, receiver
C1S65_RS11600	COG0583	DNA-binding transcription factor activity
C1S65_RS11630	COG2885	chlorophyll binding
C1S65_RS11640	COG1686	Belongs to the peptidase S11 family
C1S65_RS11665	COG2814	Major facilitator Superfamily
C1S65_RS11685	COG2323	membrane
C1S65_RS11695	COG1058	Belongs to the CinA family
C1S65_RS11695	COG1546	Belongs to the CinA family
C1S65_RS11700	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS11705	COG0693	protein deglycase activity
C1S65_RS11720	COG0028	Belongs to the TPP enzyme family
C1S65_RS11725	COG4297	protein containing double-stranded beta helix domain
C1S65_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS11785	COG4566	intracellular signal transduction
C1S65_RS11795	COG4191	Histidine kinase
C1S65_RS11800	COG2807	transmembrane transport
C1S65_RS11805	COG2207	Transcriptional regulator
C1S65_RS11810	COG2205	protein histidine kinase activity
C1S65_RS11840	COG3685	Protein conserved in bacteria
C1S65_RS11855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1S65_RS11865	COG1063	alcohol dehydrogenase
C1S65_RS11875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS11885	COG1199	ATP-dependent helicase activity
C1S65_RS11885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1S65_RS11900	COG0210	DNA helicase
C1S65_RS11910	COG0477	Major facilitator Superfamily
C1S65_RS11920	COG2964	Protein conserved in bacteria
C1S65_RS11925	COG0154	amidase activity
C1S65_RS11930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S65_RS11935	COG0625	glutathione transferase activity
C1S65_RS11940	COG1252	NADH dehydrogenase
C1S65_RS11950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S65_RS11955	COG4638	Rieske (2fe-2S)
C1S65_RS11960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S65_RS11970	COG0583	DNA-binding transcription factor activity
C1S65_RS11975	COG0697	spore germination
C1S65_RS11980	COG0393	Putative heavy-metal-binding
C1S65_RS12010	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1S65_RS12015	COG0183	Belongs to the thiolase family
C1S65_RS12025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S65_RS12030	COG0590	tRNA wobble adenosine to inosine editing
C1S65_RS12035	COG2807	transmembrane transport
C1S65_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS12050	COG4977	sequence-specific DNA binding
C1S65_RS12055	COG0583	DNA-binding transcription factor activity
C1S65_RS12070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS12075	COG2358	TRAP transporter, solute receptor (TAXI family
C1S65_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS12090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1S65_RS12095	COG0583	DNA-binding transcription factor activity
C1S65_RS12100	COG1942	4-Oxalocrotonate Tautomerase
C1S65_RS12115	COG4991	sh3 domain protein
C1S65_RS12120	COG1611	Belongs to the LOG family
C1S65_RS12145	COG1686	Belongs to the peptidase S11 family
C1S65_RS12160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1S65_RS12200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1S65_RS12210	COG3850	Histidine kinase
C1S65_RS12210	COG2205	protein histidine kinase activity
C1S65_RS12210	COG4999	Histidine kinase
C1S65_RS12210	COG3437	response regulator, receiver
C1S65_RS12215	COG2205	protein histidine kinase activity
C1S65_RS12215	COG2198	Histidine kinase
C1S65_RS12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS12215	COG0784	Response regulator, receiver
C1S65_RS12240	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS12255	COG0840	transmembrane signaling receptor activity
C1S65_RS12260	COG2056	Na+-H+ antiporter family
C1S65_RS12265	COG0583	DNA-binding transcription factor activity
C1S65_RS12270	COG3493	citrate carrier protein
C1S65_RS12275	COG0066	3-isopropylmalate dehydratase activity
C1S65_RS12280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1S65_RS12285	COG3226	Transcriptional regulator
C1S65_RS12300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS12315	COG2207	Transcriptional regulator
C1S65_RS12325	COG0477	Major facilitator Superfamily
C1S65_RS12330	COG0583	DNA-binding transcription factor activity
C1S65_RS12335	COG1027	Aspartate ammonia-lyase
C1S65_RS12345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS12350	COG0583	DNA-binding transcription factor activity
C1S65_RS12355	COG1760	l-serine dehydratase
C1S65_RS12360	COG0814	amino acid
C1S65_RS12365	COG0596	Alpha beta hydrolase
C1S65_RS12385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS12395	COG0174	glutamine synthetase
C1S65_RS12440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1S65_RS12475	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS12480	COG0667	Aldo Keto reductase
C1S65_RS12490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S65_RS12500	COG3284	Transcriptional regulator
C1S65_RS12505	COG1132	(ABC) transporter
C1S65_RS12525	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS12550	COG0318	PFAM AMP-dependent synthetase and ligase
C1S65_RS12555	COG0746	molybdenum cofactor guanylyltransferase activity
C1S65_RS12565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS12570	COG0745	RESPONSE REGULATOR receiver
C1S65_RS12575	COG2205	protein histidine kinase activity
C1S65_RS12580	COG0488	(ABC) transporter
C1S65_RS12590	COG0753	catalase activity
C1S65_RS12595	COG1126	abc transporter atp-binding protein
C1S65_RS12600	COG0765	amino acid transport
C1S65_RS12605	COG0765	amino acid transport
C1S65_RS12610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS12615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS12620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1S65_RS12625	COG2423	ornithine cyclodeaminase activity
C1S65_RS12630	COG0006	proline dipeptidase activity
C1S65_RS12635	COG3608	succinylglutamate desuccinylase aspartoacylase
C1S65_RS12640	COG1522	sequence-specific DNA binding
C1S65_RS12645	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS12650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1S65_RS12655	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS12660	COG0583	DNA-binding transcription factor activity
C1S65_RS12675	COG2207	Transcriptional regulator
C1S65_RS12680	COG0300	oxidoreductase activity
C1S65_RS12695	COG2011	ABC-type metal ion transport system permease component
C1S65_RS12715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1S65_RS12775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1S65_RS12800	COG2837	iron assimilation
C1S65_RS12820	COG0826	peptidase U32
C1S65_RS12840	COG2851	Citrate transporter
C1S65_RS12860	COG2384	SAM-dependent methyltransferase
C1S65_RS12870	COG0583	DNA-binding transcription factor activity
C1S65_RS12890	COG2271	Major facilitator Superfamily
C1S65_RS12895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S65_RS12900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S65_RS12905	COG0583	DNA-binding transcription factor activity
C1S65_RS12915	COG1064	alcohol dehydrogenase
C1S65_RS12920	COG1473	amidohydrolase
C1S65_RS12930	COG0154	amidase activity
C1S65_RS12955	COG1126	abc transporter atp-binding protein
C1S65_RS12965	COG1966	Carbon starvation protein
C1S65_RS12970	COG2879	small protein
C1S65_RS12990	COG2822	iron ion transport
C1S65_RS13000	COG2822	iron ion transport
C1S65_RS13005	COG0672	)-iron permease
C1S65_RS13030	COG0678	peroxiredoxin activity
C1S65_RS13035	COG0789	Transcriptional regulator
C1S65_RS13040	COG2814	Major facilitator Superfamily
C1S65_RS13050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1S65_RS13055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1S65_RS13060	COG2080	2 iron, 2 sulfur cluster binding
C1S65_RS13065	COG0028	Belongs to the TPP enzyme family
C1S65_RS13070	COG0583	DNA-binding transcription factor activity
C1S65_RS13075	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS13080	COG2271	Major facilitator Superfamily
C1S65_RS13085	COG3959	Transketolase, thiamine diphosphate binding domain
C1S65_RS13090	COG3958	Transketolase
C1S65_RS13105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S65_RS13110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S65_RS13115	COG2814	Major facilitator Superfamily
C1S65_RS13155	COG1414	Transcriptional regulator
C1S65_RS13210	COG3685	Protein conserved in bacteria
C1S65_RS13230	COG0402	S-adenosylhomocysteine deaminase activity
C1S65_RS13245	COG0583	DNA-binding transcription factor activity
C1S65_RS13300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S65_RS13315	COG1917	Cupin 2, conserved barrel domain protein
C1S65_RS13325	COG0583	DNA-binding transcription factor activity
C1S65_RS13330	COG3038	cytochrome b561
C1S65_RS13335	COG0753	catalase activity
C1S65_RS13340	COG1733	regulation of RNA biosynthetic process
C1S65_RS13345	COG2207	Transcriptional regulator
C1S65_RS13350	COG2807	transmembrane transport
C1S65_RS13370	COG2706	6-phosphogluconolactonase activity
C1S65_RS13375	COG2828	Protein conserved in bacteria
C1S65_RS13380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1S65_RS13385	COG2851	Citrate transporter
C1S65_RS13440	COG1205	dead DEAH box helicase
C1S65_RS13440	COG1111	helicase
C1S65_RS13460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1S65_RS13500	COG0583	DNA-binding transcription factor activity
C1S65_RS13515	COG3327	negative regulation of DNA-templated transcription, initiation
C1S65_RS13525	COG1024	Enoyl-CoA hydratase
C1S65_RS13530	COG1024	Enoyl-CoA hydratase
C1S65_RS13535	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1S65_RS13540	COG2050	protein possibly involved in aromatic compounds catabolism
C1S65_RS13545	COG0183	Belongs to the thiolase family
C1S65_RS13555	COG3396	Phenylacetate-CoA oxygenase
C1S65_RS13560	COG3460	Phenylacetate-CoA oxygenase
C1S65_RS13565	COG3396	Phenylacetate-CoA oxygenase
C1S65_RS13570	COG2151	metal-sulfur cluster biosynthetic enzyme
C1S65_RS13575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S65_RS13595	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS13595	COG2030	dehydratase
C1S65_RS13600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S65_RS13610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S65_RS13620	COG0583	DNA-binding transcription factor activity
C1S65_RS13625	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS13635	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS13640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1S65_RS13645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S65_RS13650	COG4166	transmembrane transport
C1S65_RS13655	COG4174	ABC transporter (Permease)
C1S65_RS13660	COG4239	(ABC) transporter, permease
C1S65_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS13670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S65_RS13675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1S65_RS13700	COG0577	efflux transmembrane transporter activity
C1S65_RS13700	COG1136	(ABC) transporter
C1S65_RS13705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS13745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1S65_RS13745	COG0515	serine threonine protein kinase
C1S65_RS13770	COG2814	Major facilitator Superfamily
C1S65_RS13790	COG0583	DNA-binding transcription factor activity
C1S65_RS13815	COG3257	ureidoglycine aminohydrolase activity
C1S65_RS13835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS13870	COG4191	Histidine kinase
C1S65_RS13870	COG0784	Response regulator, receiver
C1S65_RS13885	COG2200	EAL domain
C1S65_RS13895	COG1253	flavin adenine dinucleotide binding
C1S65_RS13905	COG2207	Transcriptional regulator
C1S65_RS13910	COG1396	sequence-specific DNA binding
C1S65_RS13915	COG0235	Class ii aldolase
C1S65_RS13920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S65_RS13930	COG1126	abc transporter atp-binding protein
C1S65_RS13935	COG0765	amino acid transport
C1S65_RS13940	COG0765	amino acid transport
C1S65_RS13945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1S65_RS13955	COG0477	Major facilitator Superfamily
C1S65_RS13975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1S65_RS13980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1S65_RS14010	COG2259	Doxx family
C1S65_RS14020	COG3220	belongs to the UPF0276 family
C1S65_RS14035	COG0417	DNA replication proofreading
C1S65_RS14050	COG1040	competence protein
C1S65_RS14060	COG0738	Major facilitator superfamily
C1S65_RS14085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS14105	COG2945	thiolester hydrolase activity
C1S65_RS14135	COG3813	Protein conserved in bacteria
C1S65_RS14140	COG2197	response regulator
C1S65_RS14145	COG2205	protein histidine kinase activity
C1S65_RS14145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS14155	COG1609	Transcriptional regulator
C1S65_RS14160	COG3265	gluconokinase activity
C1S65_RS14185	COG0251	oxidation-reduction process
C1S65_RS14190	COG0019	diaminopimelate decarboxylase activity
C1S65_RS14200	COG0251	oxidation-reduction process
C1S65_RS14205	COG0579	oxidoreductase
C1S65_RS14245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1S65_RS14250	COG0830	nickel cation binding
C1S65_RS14260	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C1S65_RS14265	COG0804	urea catabolic process
C1S65_RS14270	COG0832	Belongs to the urease beta subunit family
C1S65_RS14275	COG0831	urea catabolic process
C1S65_RS14280	COG0829	nickel cation binding
C1S65_RS14290	COG4774	siderophore transport
C1S65_RS14300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1S65_RS14305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S65_RS14310	COG2271	Major facilitator Superfamily
C1S65_RS14315	COG2721	sulfolactate sulfo-lyase activity
C1S65_RS14320	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS14330	COG1017	nitric oxide dioxygenase activity
C1S65_RS14330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S65_RS14335	COG2186	Transcriptional regulator
C1S65_RS14340	COG2207	Transcriptional regulator
C1S65_RS14380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1S65_RS14415	COG1846	Transcriptional regulator
C1S65_RS14420	COG2267	carboxylic ester hydrolase activity
C1S65_RS14425	COG2807	transmembrane transport
C1S65_RS14430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S65_RS14440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S65_RS14450	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1S65_RS14455	COG1177	transmembrane transport
C1S65_RS14460	COG3842	ATPase activity
C1S65_RS14470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S65_RS14475	COG0235	Class ii aldolase
C1S65_RS14480	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS14480	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S65_RS14495	COG0583	DNA-binding transcription factor activity
C1S65_RS14505	COG3773	Cell wall hydrolase
C1S65_RS14520	COG0346	lactoylglutathione lyase activity
C1S65_RS14530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C1S65_RS14575	COG0814	amino acid
C1S65_RS14595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S65_RS14605	COG0747	negative chemotaxis
C1S65_RS14610	COG1280	lysine exporter protein (LysE YggA)
C1S65_RS14620	COG2391	methyltransferase activity
C1S65_RS14625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1S65_RS14630	COG2226	methyltransferase
C1S65_RS14670	COG1999	signal sequence binding
C1S65_RS14675	COG0316	Belongs to the HesB IscA family
C1S65_RS14675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1S65_RS14680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S65_RS14695	COG3829	transcription factor binding
C1S65_RS14700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS14710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS14715	COG0747	negative chemotaxis
C1S65_RS14725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS14730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS14735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS14740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS14740	COG1116	anion transmembrane transporter activity
C1S65_RS14785	COG1595	DNA-templated transcription, initiation
C1S65_RS14795	COG3038	cytochrome b561
C1S65_RS14805	COG1917	Cupin 2, conserved barrel domain protein
C1S65_RS14805	COG1396	sequence-specific DNA binding
C1S65_RS14820	COG4221	oxidoreductase activity
C1S65_RS14825	COG1309	transcriptional regulator
C1S65_RS14835	COG0583	DNA-binding transcription factor activity
C1S65_RS14855	COG2814	Major facilitator Superfamily
C1S65_RS14865	COG1064	alcohol dehydrogenase
C1S65_RS14870	COG2207	Transcriptional regulator
C1S65_RS14880	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S65_RS14885	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C1S65_RS14895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S65_RS14910	COG4774	siderophore transport
C1S65_RS14950	COG0667	Aldo Keto reductase
C1S65_RS14955	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS14960	COG0477	Major facilitator Superfamily
C1S65_RS14965	COG0583	DNA-binding transcription factor activity
C1S65_RS14985	COG2271	Major facilitator Superfamily
C1S65_RS14990	COG4948	Mandelate Racemase Muconate Lactonizing
C1S65_RS15015	COG0583	DNA-binding transcription factor activity
C1S65_RS15025	COG0583	DNA-binding transcription factor activity
C1S65_RS15030	COG2828	Protein conserved in bacteria
C1S65_RS15035	COG1301	dicarboxylic acid transport
C1S65_RS15040	COG2851	Citrate transporter
C1S65_RS15060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S65_RS15090	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S65_RS15095	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS15120	COG0583	DNA-binding transcription factor activity
C1S65_RS15125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS15140	COG0477	Major facilitator Superfamily
C1S65_RS15145	COG0583	DNA-binding transcription factor activity
C1S65_RS15150	COG0494	nUDIX hydrolase
C1S65_RS15155	COG1944	ATP diphosphatase activity
C1S65_RS15165	COG5001	Diguanylate cyclase
C1S65_RS15165	COG3300	MHYT domain
C1S65_RS15195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S65_RS15200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS15205	COG1116	anion transmembrane transporter activity
C1S65_RS15220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1S65_RS15225	COG0251	oxidation-reduction process
C1S65_RS15245	COG0583	DNA-binding transcription factor activity
C1S65_RS15250	COG4654	Cytochrome c, class I
C1S65_RS15255	COG0583	DNA-binding transcription factor activity
C1S65_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS15285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S65_RS15295	COG0747	negative chemotaxis
C1S65_RS15300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS15320	COG1132	(ABC) transporter
C1S65_RS15325	COG1132	(ABC) transporter
C1S65_RS15330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS15350	COG4771	TonB-dependent receptor
C1S65_RS15355	COG4206	TonB-dependent receptor
C1S65_RS15360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS15365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS15370	COG1116	anion transmembrane transporter activity
C1S65_RS15385	COG0165	Argininosuccinate lyase
C1S65_RS15390	COG0765	amino acid transport
C1S65_RS15400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS15405	COG2814	Major facilitator Superfamily
C1S65_RS15420	COG1126	abc transporter atp-binding protein
C1S65_RS15425	COG0765	amino acid transport
C1S65_RS15430	COG0765	amino acid transport
C1S65_RS15440	COG0583	DNA-binding transcription factor activity
C1S65_RS15450	COG0488	(ABC) transporter
C1S65_RS15455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1S65_RS15460	COG0745	RESPONSE REGULATOR receiver
C1S65_RS15465	COG2205	protein histidine kinase activity
C1S65_RS15470	COG0215	cysteine-tRNA ligase activity
C1S65_RS15475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S65_RS15485	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S65_RS15490	COG2366	antibiotic biosynthetic process
C1S65_RS15530	COG0729	surface antigen
C1S65_RS15540	COG0708	Exodeoxyribonuclease III
C1S65_RS15555	COG1476	TRANSCRIPTIONal
C1S65_RS15570	COG1285	pathogenesis
C1S65_RS15580	COG0348	domain, Protein
C1S65_RS15585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS15600	COG2814	Major facilitator Superfamily
C1S65_RS15605	COG1566	PFAM secretion protein HlyD family protein
C1S65_RS15610	COG1846	Transcriptional regulator
C1S65_RS15630	COG5001	Diguanylate cyclase
C1S65_RS15630	COG3300	MHYT domain
C1S65_RS15645	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1S65_RS15660	COG5001	Diguanylate cyclase
C1S65_RS15680	COG1309	transcriptional regulator
C1S65_RS15685	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C1S65_RS15685	COG1082	Xylose isomerase domain protein TIM barrel
C1S65_RS15690	COG0477	Major facilitator Superfamily
C1S65_RS15695	COG0076	glutamate decarboxylase activity
C1S65_RS15700	COG0583	DNA-binding transcription factor activity
C1S65_RS15705	COG0217	transcriptional regulatory protein
C1S65_RS15710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS15720	COG0583	DNA-binding transcription factor activity
C1S65_RS15730	COG4106	trans-aconitate 2-methyltransferase activity
C1S65_RS15745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS15750	COG0587	DNA-directed DNA polymerase activity
C1S65_RS15765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1S65_RS15805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S65_RS15810	COG2814	Major facilitator Superfamily
C1S65_RS15815	COG0583	DNA-binding transcription factor activity
C1S65_RS15825	COG1959	2 iron, 2 sulfur cluster binding
C1S65_RS15840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S65_RS15850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S65_RS15860	COG2267	carboxylic ester hydrolase activity
C1S65_RS15865	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS15875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S65_RS15880	COG2186	Transcriptional regulator
C1S65_RS15890	COG4191	Histidine kinase
C1S65_RS15890	COG0784	Response regulator, receiver
C1S65_RS15895	COG0784	Response regulator, receiver
C1S65_RS15895	COG4191	Histidine kinase
C1S65_RS15900	COG1280	lysine exporter protein (LysE YggA)
C1S65_RS15920	COG0583	DNA-binding transcription factor activity
C1S65_RS15925	COG3180	Ammonia monooxygenase
C1S65_RS15930	COG0277	FAD linked oxidase domain protein
C1S65_RS15935	COG0277	FAD linked oxidase domain protein
C1S65_RS15940	COG0247	lactate metabolic process
C1S65_RS15955	COG1280	lysine exporter protein (LysE YggA)
C1S65_RS15965	COG0402	S-adenosylhomocysteine deaminase activity
C1S65_RS15970	COG2508	Transcriptional regulator
C1S65_RS15975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S65_RS16040	COG0776	regulation of translation
C1S65_RS16045	COG0072	phenylalanine-tRNA ligase activity
C1S65_RS16050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1S65_RS16055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1S65_RS16060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1S65_RS16065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1S65_RS16070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1S65_RS16080	COG1278	Cold shock
C1S65_RS16100	COG1869	D-ribose catabolic process
C1S65_RS16105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S65_RS16110	COG1609	Transcriptional regulator
C1S65_RS16115	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1S65_RS16120	COG1129	ABC transporter
C1S65_RS16130	COG0252	asparaginase activity
C1S65_RS16140	COG2356	endonuclease I
C1S65_RS16145	COG0667	Aldo Keto reductase
C1S65_RS16155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S65_RS16180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS16195	COG1253	flavin adenine dinucleotide binding
C1S65_RS16205	COG0583	DNA-binding transcription factor activity
C1S65_RS16210	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1S65_RS16215	COG3132	Protein of unknown function, DUF480
C1S65_RS16225	COG3634	alkyl hydroperoxide reductase activity
C1S65_RS16240	COG3121	Chaperone
C1S65_RS16265	COG3258	Cytochrome c
C1S65_RS16270	COG2863	cytochrome
C1S65_RS16295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1S65_RS16305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1S65_RS16310	COG0745	RESPONSE REGULATOR receiver
C1S65_RS16315	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C1S65_RS16320	COG4191	Histidine kinase
C1S65_RS16320	COG0784	Response regulator, receiver
C1S65_RS16335	COG2259	Doxx family
C1S65_RS16365	COG2203	Gaf domain
C1S65_RS16365	COG2200	EAL domain
C1S65_RS16365	COG2199	diguanylate cyclase activity
C1S65_RS16420	COG2135	peptidase activity
C1S65_RS16645	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C1S65_RS16755	COG0629	single-stranded DNA binding
C1S65_RS16840	COG0616	signal peptide processing
C1S65_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS16865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S65_RS16880	COG5001	Diguanylate cyclase
C1S65_RS16925	COG2271	Major facilitator Superfamily
C1S65_RS16935	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C1S65_RS16975	COG0730	response to heat
C1S65_RS16980	COG2816	NAD+ diphosphatase activity
C1S65_RS16985	COG1024	Enoyl-CoA hydratase
C1S65_RS16995	COG1234	tRNA 3'-trailer cleavage
C1S65_RS17010	COG2271	Major facilitator Superfamily
C1S65_RS17035	COG0515	serine threonine protein kinase
C1S65_RS17065	COG0583	DNA-binding transcription factor activity
C1S65_RS17075	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C1S65_RS17195	COG1595	DNA-templated transcription, initiation
C1S65_RS17210	COG1953	Uracil, thiamine, allantoin
C1S65_RS17220	COG0493	'glutamate synthase
C1S65_RS17230	COG1309	transcriptional regulator
C1S65_RS17240	COG0628	permease
C1S65_RS17245	COG0826	peptidase U32
C1S65_RS17265	COG1238	metal cluster binding
C1S65_RS17270	COG0596	Alpha beta hydrolase
C1S65_RS17280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1S65_RS17285	COG2133	pyrroloquinoline quinone binding
C1S65_RS17315	COG0589	response to stress
C1S65_RS17345	COG5006	permease, DMT superfamily
C1S65_RS17385	COG1335	isochorismatase
C1S65_RS17400	COG2111	Na H antiporter
C1S65_RS17400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1S65_RS17405	COG1006	Multisubunit Na H antiporter MnhC subunit
C1S65_RS17410	COG0651	ATP synthesis coupled electron transport
C1S65_RS17420	COG2212	antiporter activity
C1S65_RS17425	COG1320	monovalent cation:proton antiporter activity
C1S65_RS17460	COG1024	Enoyl-CoA hydratase
C1S65_RS17465	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS17470	COG0183	Belongs to the thiolase family
C1S65_RS17480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S65_RS17500	COG0583	DNA-binding transcription factor activity
C1S65_RS17505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1S65_RS17515	COG0431	NADPH-dependent FMN reductase
C1S65_RS17535	COG0328	RNA-DNA hybrid ribonuclease activity
C1S65_RS17545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S65_RS17550	COG0741	lytic transglycosylase activity
C1S65_RS17550	COG1388	LysM domain
C1S65_RS17555	COG4166	transmembrane transport
C1S65_RS17560	COG4166	transmembrane transport
C1S65_RS17565	COG4174	ABC transporter (Permease)
C1S65_RS17570	COG4239	(ABC) transporter, permease
C1S65_RS17575	COG4172	Belongs to the ABC transporter superfamily
C1S65_RS17580	COG2271	Major facilitator Superfamily
C1S65_RS17590	COG2205	protein histidine kinase activity
C1S65_RS17595	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1S65_RS17605	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1S65_RS17615	COG0628	permease
C1S65_RS17625	COG0596	Alpha beta hydrolase
C1S65_RS17645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1S65_RS17660	COG4999	Histidine kinase
C1S65_RS17660	COG2205	protein histidine kinase activity
C1S65_RS17660	COG3850	Histidine kinase
C1S65_RS17660	COG3437	response regulator, receiver
C1S65_RS17665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1S65_RS17680	COG1741	Belongs to the pirin family
C1S65_RS17690	COG0326	Molecular chaperone. Has ATPase activity
C1S65_RS17725	COG0045	succinate-CoA ligase (ADP-forming) activity
C1S65_RS17730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S65_RS17750	COG1053	succinate dehydrogenase
C1S65_RS17755	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1S65_RS17760	COG2009	succinate dehydrogenase
C1S65_RS17785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S65_RS17790	COG2885	chlorophyll binding
C1S65_RS17840	COG3383	formate dehydrogenase (NAD+) activity
C1S65_RS17905	COG2135	peptidase activity
C1S65_RS17920	COG3179	chitinase
C1S65_RS18075	COG4197	protein conserved in bacteria, prophage-related
C1S65_RS18125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S65_RS18130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1S65_RS18145	COG2204	response regulator
C1S65_RS18150	COG0667	Aldo Keto reductase
C1S65_RS18155	COG0583	DNA-binding transcription factor activity
C1S65_RS18175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1S65_RS18175	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1S65_RS18195	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1S65_RS18200	COG1136	(ABC) transporter
C1S65_RS18205	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1S65_RS18220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S65_RS18225	COG1477	protein flavinylation
C1S65_RS18235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1S65_RS18245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1S65_RS18255	COG1376	ErfK ybiS ycfS ynhG family protein
C1S65_RS18300	COG0183	Belongs to the thiolase family
C1S65_RS18305	COG1024	Enoyl-CoA hydratase
C1S65_RS18305	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1S65_RS18315	COG0589	response to stress
C1S65_RS18320	COG0488	(ABC) transporter
C1S65_RS18325	COG0741	lytic transglycosylase activity
C1S65_RS18335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1S65_RS18375	COG3123	guanosine phosphorylase activity
C1S65_RS18385	COG3278	Belongs to the heme-copper respiratory oxidase family
C1S65_RS18400	COG2010	Cytochrome c
C1S65_RS18410	COG3278	Belongs to the heme-copper respiratory oxidase family
C1S65_RS18425	COG2010	Cytochrome c
C1S65_RS18430	COG0348	domain, Protein
C1S65_RS18440	COG2217	Heavy metal translocating P-type atpase
C1S65_RS18460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S65_RS18465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1S65_RS18470	COG0116	Belongs to the methyltransferase superfamily
C1S65_RS18470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1S65_RS18480	COG1522	sequence-specific DNA binding
C1S65_RS18485	COG1953	Uracil, thiamine, allantoin
C1S65_RS18525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S65_RS18550	COG1138	Cytochrome C-type biogenesis protein
C1S65_RS18555	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1S65_RS18575	COG4133	protoheme IX ABC transporter activity
C1S65_RS18585	COG2257	FlhB HrpN YscU SpaS Family
C1S65_RS18595	COG0835	chemotaxis
C1S65_RS18605	COG1192	Involved in chromosome partitioning
C1S65_RS18610	COG1360	Flagellar Motor Protein
C1S65_RS18615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1S65_RS18620	COG2201	protein-glutamate methylesterase activity
C1S65_RS18625	COG2198	Histidine kinase
C1S65_RS18625	COG0784	Response regulator, receiver
C1S65_RS18625	COG0643	Histidine kinase
C1S65_RS18630	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1S65_RS18655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1S65_RS18665	COG1684	flagellar biosynthetic protein fliR
C1S65_RS18670	COG1987	bacterial-type flagellum assembly
C1S65_RS18715	COG0745	RESPONSE REGULATOR receiver
C1S65_RS18725	COG2882	bacterial-type flagellum organization
C1S65_RS18750	COG1677	Flagellar hook-basal body complex protein FliE
C1S65_RS18790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1S65_RS18820	COG1256	bacterial-type flagellum assembly
C1S65_RS18830	COG1706	bacterial-type flagellum-dependent cell motility
C1S65_RS18835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1S65_RS18845	COG4787	bacterial-type flagellum-dependent cell motility
C1S65_RS18870	COG1815	bacterial-type flagellum-dependent cell motility
C1S65_RS18880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1S65_RS18885	COG0835	chemotaxis
C1S65_RS18885	COG0784	Response regulator, receiver
C1S65_RS18905	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C1S65_RS18910	COG0477	Major facilitator Superfamily
C1S65_RS18920	COG1522	sequence-specific DNA binding
C1S65_RS18925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1S65_RS18930	COG0022	dehydrogenase e1 component
C1S65_RS18940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S65_RS18965	COG2239	Acts as a magnesium transporter
C1S65_RS18990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1S65_RS18995	COG0527	aspartate kinase activity
C1S65_RS19000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1S65_RS19010	COG2988	succinylglutamate desuccinylase activity
C1S65_RS19020	COG3724	N-succinylarginine dihydrolase activity
C1S65_RS19025	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS19040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S65_RS19065	COG4215	(ABC) transporter
C1S65_RS19070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS19075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S65_RS19100	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1S65_RS19110	COG0277	FAD linked oxidase domain protein
C1S65_RS19110	COG0247	lactate metabolic process
C1S65_RS19120	COG1113	amino acid transport
C1S65_RS19130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1S65_RS19140	COG0009	L-threonylcarbamoyladenylate synthase
C1S65_RS19145	COG0613	PHP domain protein
C1S65_RS19150	COG2917	probably involved in intracellular septation
C1S65_RS19155	COG2350	Protein conserved in bacteria
C1S65_RS19165	COG0745	RESPONSE REGULATOR receiver
C1S65_RS19175	COG0583	DNA-binding transcription factor activity
C1S65_RS19185	COG0583	DNA-binding transcription factor activity
C1S65_RS19190	COG1846	Transcriptional regulator
C1S65_RS19195	COG1764	response to oxidative stress
C1S65_RS19200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1S65_RS19220	COG0583	DNA-binding transcription factor activity
C1S65_RS19225	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS19250	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C1S65_RS19260	COG4774	siderophore transport
C1S65_RS19265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1S65_RS19285	COG0598	Magnesium transport protein CorA
C1S65_RS19290	COG0519	Catalyzes the synthesis of GMP from XMP
C1S65_RS19310	COG1368	sulfuric ester hydrolase activity
C1S65_RS19340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C1S65_RS19345	COG2814	Major facilitator Superfamily
C1S65_RS19350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1S65_RS19380	COG2840	Smr protein MutS2
C1S65_RS19385	COG0302	gtp cyclohydrolase
C1S65_RS19395	COG0625	glutathione transferase activity
C1S65_RS19400	COG3135	benzoate transporter
C1S65_RS19405	COG0840	transmembrane signaling receptor activity
C1S65_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS19425	COG2130	NADP-dependent
C1S65_RS19430	COG0284	orotidine-5'-phosphate decarboxylase activity
C1S65_RS19440	COG1555	photosystem II stabilization
C1S65_RS19450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1S65_RS19460	COG0438	transferase activity, transferring glycosyl groups
C1S65_RS19470	COG1045	serine acetyltransferase
C1S65_RS19495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1S65_RS19500	COG1088	dTDP-glucose 4,6-dehydratase activity
C1S65_RS19505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S65_RS19510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1S65_RS19530	COG0438	transferase activity, transferring glycosyl groups
C1S65_RS19540	COG0776	regulation of translation
C1S65_RS19555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1S65_RS19560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1S65_RS19570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1S65_RS19580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C1S65_RS19585	COG0402	S-adenosylhomocysteine deaminase activity
C1S65_RS19590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S65_RS19595	COG0546	phosphoglycolate phosphatase activity
C1S65_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS19610	COG5001	Diguanylate cyclase
C1S65_RS19610	COG5002	protein histidine kinase activity
C1S65_RS19625	COG1054	Belongs to the UPF0176 family
C1S65_RS19630	COG0271	Belongs to the BolA IbaG family
C1S65_RS19640	COG0114	fumarate hydratase activity
C1S65_RS19645	COG0697	spore germination
C1S65_RS19650	COG2326	polyphosphate kinase activity
C1S65_RS19655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1S65_RS19655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S65_RS19660	COG0367	asparagine synthase
C1S65_RS19665	COG0189	ligase activity
C1S65_RS19665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1S65_RS19670	COG1363	Peptidase, m42
C1S65_RS19675	COG3089	Belongs to the UPF0270 family
C1S65_RS19680	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1S65_RS19690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS19690	COG2205	protein histidine kinase activity
C1S65_RS19695	COG2197	response regulator
C1S65_RS19720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S65_RS19725	COG3162	membrane
C1S65_RS19730	COG2113	Glycine betaine
C1S65_RS19755	COG2853	Lipoprotein
C1S65_RS19765	COG1560	Kdo2-lipid A biosynthetic process
C1S65_RS19770	COG0850	regulation of cytokinetic process
C1S65_RS19775	COG2894	cell division
C1S65_RS19780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1S65_RS19785	COG0564	pseudouridine synthase activity
C1S65_RS19790	COG1362	aminopeptidase activity
C1S65_RS19795	COG0668	transmembrane transport
C1S65_RS19815	COG0395	ABC-type sugar transport system, permease component
C1S65_RS19845	COG2200	EAL domain
C1S65_RS19860	COG3339	Conserved Protein
C1S65_RS19865	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S65_RS19875	COG0583	DNA-binding transcription factor activity
C1S65_RS19905	COG2146	nitrite reductase [NAD(P)H] activity
C1S65_RS19905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S65_RS19910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S65_RS19910	COG2146	nitrite reductase [NAD(P)H] activity
C1S65_RS19915	COG0243	molybdopterin cofactor binding
C1S65_RS19925	COG0024	Methionine aminopeptidase
C1S65_RS19935	COG2214	Heat shock protein DnaJ domain protein
C1S65_RS19940	COG0443	Heat shock 70 kDa protein
C1S65_RS19960	COG2974	May be involved in recombination
C1S65_RS19965	COG0385	Bile acid
C1S65_RS19970	COG2076	Multidrug Resistance protein
C1S65_RS19980	COG0840	transmembrane signaling receptor activity
C1S65_RS19985	COG3618	amidohydrolase
C1S65_RS19990	COG2814	Major facilitator Superfamily
C1S65_RS19995	COG2188	Transcriptional regulator
C1S65_RS20005	COG2814	Major facilitator Superfamily
C1S65_RS20010	COG2205	protein histidine kinase activity
C1S65_RS20070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1S65_RS20075	COG0406	alpha-ribazole phosphatase activity
C1S65_RS20080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1S65_RS20090	COG1492	cobalamin metabolic process
C1S65_RS20100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1S65_RS20105	COG0778	Nitroreductase
C1S65_RS20110	COG1797	cobyrinic acid a,c-diamide synthase activity
C1S65_RS20125	COG0791	NLP P60 protein
C1S65_RS20130	COG0791	NLP P60 protein
C1S65_RS20175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1S65_RS20180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1S65_RS20185	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1S65_RS20190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S65_RS20200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1S65_RS20210	COG0425	Belongs to the sulfur carrier protein TusA family
C1S65_RS20220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1S65_RS20225	COG5339	Protein conserved in bacteria
C1S65_RS20235	COG0531	amino acid
C1S65_RS20240	COG0840	transmembrane signaling receptor activity
C1S65_RS20245	COG1414	Transcriptional regulator
C1S65_RS20250	COG3842	ATPase activity
C1S65_RS20255	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1S65_RS20260	COG1177	transmembrane transport
C1S65_RS20290	COG0463	Glycosyl transferase, family 2
C1S65_RS20305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1S65_RS20310	COG0602	queuosine metabolic process
C1S65_RS20315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1S65_RS20320	COG2885	chlorophyll binding
C1S65_RS20325	COG0823	Involved in the tonB-independent uptake of proteins
C1S65_RS20345	COG0824	Thioesterase
C1S65_RS20350	COG2255	four-way junction helicase activity
C1S65_RS20355	COG0632	four-way junction helicase activity
C1S65_RS20360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1S65_RS20365	COG0217	transcriptional regulatory protein
C1S65_RS20370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1S65_RS20385	COG0783	Belongs to the Dps family
C1S65_RS20395	COG2900	Belongs to the SlyX family
C1S65_RS20410	COG0442	prolyl-tRNA aminoacylation
C1S65_RS20420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1S65_RS20450	COG3158	transport of potassium into the cell
C1S65_RS20455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1S65_RS20470	COG4807	Protein conserved in bacteria
C1S65_RS20485	COG0583	DNA-binding transcription factor activity
C1S65_RS20500	COG3148	PFAM DTW domain containing protein
C1S65_RS20520	COG2137	regulation of response to DNA damage stimulus
C1S65_RS20525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1S65_RS20530	COG1546	Belongs to the CinA family
C1S65_RS20540	COG3179	chitinase
C1S65_RS20635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1S65_RS20640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1S65_RS20655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1S65_RS20660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1S65_RS20665	COG0585	pseudouridine synthase activity
C1S65_RS20670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1S65_RS20680	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1S65_RS20690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1S65_RS20700	COG0148	phosphopyruvate hydratase activity
C1S65_RS20705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1S65_RS20710	COG0504	CTP synthase activity
C1S65_RS20715	COG0037	tRNA processing
C1S65_RS20720	COG0825	malonyl-CoA metabolic process
C1S65_RS20730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1S65_RS20735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S65_RS20740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S65_RS20745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1S65_RS20750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1S65_RS20760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S65_RS20770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1S65_RS20780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1S65_RS20785	COG0233	cytoplasmic translational termination
C1S65_RS20790	COG0528	UMP kinase activity
C1S65_RS20795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1S65_RS20800	COG0052	Belongs to the universal ribosomal protein uS2 family
C1S65_RS20805	COG0024	Methionine aminopeptidase
C1S65_RS20810	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1S65_RS20815	COG0436	Aminotransferase
C1S65_RS20825	COG0025	NhaP-type Na H and K H
C1S65_RS20830	COG1393	Belongs to the ArsC family
C1S65_RS20835	COG2171	N-acyltransferase activity
C1S65_RS20840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1S65_RS20850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1S65_RS20855	COG1215	transferase activity, transferring glycosyl groups
C1S65_RS20860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S65_RS20865	COG2226	methyltransferase
C1S65_RS20880	COG2937	Belongs to the GPAT DAPAT family
C1S65_RS20895	COG2267	carboxylic ester hydrolase activity
C1S65_RS20915	COG0584	glycerophosphoryl diester phosphodiesterase
C1S65_RS20955	COG4191	Histidine kinase
C1S65_RS20965	COG0477	Major facilitator Superfamily
C1S65_RS20995	COG2207	Transcriptional regulator
C1S65_RS21010	COG2910	NAD(P)H-binding
C1S65_RS21020	COG0583	DNA-binding transcription factor activity
C1S65_RS21025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1S65_RS21030	COG0477	Major facilitator Superfamily
C1S65_RS21035	COG1309	transcriptional regulator
C1S65_RS21040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS21075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S65_RS21080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S65_RS21085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1S65_RS21090	COG0477	Major facilitator Superfamily
C1S65_RS21095	COG0183	Belongs to the thiolase family
C1S65_RS21100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C1S65_RS21105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C1S65_RS21110	COG2814	Major facilitator Superfamily
C1S65_RS21115	COG1414	Transcriptional regulator
C1S65_RS21125	COG0306	phosphate transporter
C1S65_RS21130	COG0433	COG0433 Predicted ATPase
C1S65_RS21135	COG0840	transmembrane signaling receptor activity
C1S65_RS21170	COG2925	Exonuclease
C1S65_RS21185	COG0469	pyruvate kinase activity
C1S65_RS21205	COG0693	protein deglycase activity
C1S65_RS21210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S65_RS21255	COG2814	Major facilitator Superfamily
C1S65_RS21260	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS21270	COG3468	outer membrane autotransporter barrel domain protein
C1S65_RS21305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S65_RS21310	COG0583	DNA-binding transcription factor activity
C1S65_RS21320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1S65_RS21350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS21355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S65_RS21365	COG3642	lipopolysaccharide core region biosynthetic process
C1S65_RS21375	COG5002	protein histidine kinase activity
C1S65_RS21375	COG5000	phosphorelay sensor kinase activity
C1S65_RS21390	COG0459	protein refolding
C1S65_RS21395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1S65_RS21400	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1S65_RS21430	COG0668	transmembrane transport
C1S65_RS21435	COG1666	GTP binding
C1S65_RS21450	COG2096	Adenosyltransferase
C1S65_RS21455	COG0352	thiamine-phosphate diphosphorylase activity
C1S65_RS21465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1S65_RS21470	COG0653	protein targeting
C1S65_RS21480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1S65_RS21485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1S65_RS21500	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1S65_RS21505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1S65_RS21510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1S65_RS21515	COG0772	Belongs to the SEDS family
C1S65_RS21520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1S65_RS21525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1S65_RS21530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1S65_RS21535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1S65_RS21550	COG0275	rRNA processing
C1S65_RS21555	COG2001	Belongs to the MraZ family
C1S65_RS21570	COG3107	peptidoglycan biosynthetic process
C1S65_RS21575	COG0792	nuclease activity
C1S65_RS21580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1S65_RS21585	COG2823	Periplasmic or secreted lipoprotein
C1S65_RS21595	COG2969	positive regulation of protein catabolic process
C1S65_RS21600	COG0625	glutathione transferase activity
C1S65_RS21605	COG2857	Cytochrome c1
C1S65_RS21610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1S65_RS21615	COG0723	plastoquinol--plastocyanin reductase activity
C1S65_RS21620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1S65_RS21625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1S65_RS21630	COG0667	Aldo Keto reductase
C1S65_RS21640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1S65_RS21645	COG0180	Tryptophanyl-tRNA synthetase
C1S65_RS21665	COG1522	sequence-specific DNA binding
C1S65_RS21670	COG4104	PAAR repeat-containing protein
C1S65_RS21685	COG0175	sulfate reduction
C1S65_RS21695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S65_RS21700	COG1126	abc transporter atp-binding protein
C1S65_RS21705	COG0765	amino acid transport
C1S65_RS21710	COG4597	amino acid ABC transporter
C1S65_RS21715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS21720	COG0400	carboxylic ester hydrolase activity
C1S65_RS21725	COG0513	Belongs to the DEAD box helicase family
C1S65_RS21735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1S65_RS21740	COG0315	cyclic pyranopterin monophosphate synthase activity
C1S65_RS21745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1S65_RS21755	COG3022	response to hydroperoxide
C1S65_RS21760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1S65_RS21765	COG1215	transferase activity, transferring glycosyl groups
C1S65_RS21770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS21775	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1S65_RS21785	COG3420	alginic acid biosynthetic process
C1S65_RS21800	COG1696	Membrane protein involved in D-alanine export
C1S65_RS21815	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C1S65_RS21815	COG0662	Cupin 2, conserved barrel domain protein
C1S65_RS21825	COG0300	oxidoreductase activity
C1S65_RS21845	COG0583	DNA-binding transcription factor activity
C1S65_RS21855	COG1566	PFAM secretion protein HlyD family protein
C1S65_RS21875	COG0583	DNA-binding transcription factor activity
C1S65_RS21880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1S65_RS21885	COG0463	Glycosyl transferase, family 2
C1S65_RS21915	COG4774	siderophore transport
C1S65_RS21920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1S65_RS21945	COG4772	TonB-dependent receptor
C1S65_RS21960	COG0019	diaminopimelate decarboxylase activity
C1S65_RS21970	COG3128	pkhd-type hydroxylase
C1S65_RS21975	COG4774	siderophore transport
C1S65_RS21990	COG0436	Aminotransferase
C1S65_RS21995	COG1160	GTP binding
C1S65_RS22010	COG0124	histidyl-tRNA synthetase
C1S65_RS22015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1S65_RS22030	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1S65_RS22035	COG0105	UTP biosynthetic process
C1S65_RS22045	COG0633	Ferredoxin
C1S65_RS22050	COG0443	Heat shock 70 kDa protein
C1S65_RS22055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1S65_RS22060	COG0316	Belongs to the HesB IscA family
C1S65_RS22070	COG1104	cysteine desulfurase activity
C1S65_RS22080	COG1045	serine acetyltransferase
C1S65_RS22095	COG3134	Outer membrane lipoprotein
C1S65_RS22110	COG1862	Preprotein translocase
C1S65_RS22115	COG0343	queuine tRNA-ribosyltransferase activity
C1S65_RS22120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1S65_RS22155	COG3706	GGDEF domain
C1S65_RS22160	COG3781	membrane
C1S65_RS22170	COG3639	organic phosphonate transmembrane transporter activity
C1S65_RS22175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1S65_RS22180	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C1S65_RS22185	COG0709	Synthesizes selenophosphate from selenide and ATP
C1S65_RS22190	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1S65_RS22205	COG0583	DNA-binding transcription factor activity
C1S65_RS22235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S65_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS22260	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS22280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S65_RS22290	COG0727	PFAM Uncharacterised protein family (UPF0153)
C1S65_RS22295	COG0436	Aminotransferase
C1S65_RS22305	COG0109	protoheme IX farnesyltransferase activity
C1S65_RS22310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1S65_RS22315	COG1845	cytochrome c oxidase, subunit III
C1S65_RS22320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1S65_RS22325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1S65_RS22335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1S65_RS22340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S65_RS22340	COG1017	nitric oxide dioxygenase activity
C1S65_RS22345	COG3604	Transcriptional regulator
C1S65_RS22375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S65_RS22400	COG3706	GGDEF domain
C1S65_RS22400	COG4251	negative regulation of phosphorylation
C1S65_RS22400	COG2203	Gaf domain
C1S65_RS22400	COG5001	Diguanylate cyclase
C1S65_RS22410	COG3530	Putative quorum-sensing-regulated virulence factor
C1S65_RS22415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1S65_RS22415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S65_RS22415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S65_RS22420	COG1105	Belongs to the carbohydrate kinase PfkB family
C1S65_RS22430	COG1609	Transcriptional regulator
C1S65_RS22435	COG0084	hydrolase, TatD family'
C1S65_RS22440	COG0456	acetyltransferase
C1S65_RS22465	COG3045	CreA protein
C1S65_RS22470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1S65_RS22475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1S65_RS22480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1S65_RS22485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1S65_RS22490	COG0142	geranyltranstransferase activity
C1S65_RS22495	COG2824	Alkylphosphonate utilization operon protein PhnA
C1S65_RS22500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1S65_RS22505	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S65_RS22515	COG2862	Uncharacterized protein family, UPF0114
C1S65_RS22525	COG1067	ATP-dependent peptidase activity
C1S65_RS22545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S65_RS22550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1S65_RS22555	COG0488	(ABC) transporter
C1S65_RS22560	COG3546	catalase activity
C1S65_RS22585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S65_RS22590	COG0523	cobalamin synthesis protein
C1S65_RS22595	COG2879	small protein
C1S65_RS22600	COG1966	Carbon starvation protein
C1S65_RS22610	COG2233	PERMEase
C1S65_RS22635	COG1629	transport
C1S65_RS22655	COG1970	mechanosensitive ion channel activity
C1S65_RS22670	COG2813	Specifically methylates the guanine in position
C1S65_RS22685	COG1294	oxidase, subunit
C1S65_RS22690	COG1271	oxidase subunit
C1S65_RS22730	COG3039	Transposase
C1S65_RS22765	COG0582	viral genome integration into host DNA
C1S65_RS22780	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS22870	COG2079	MmgE PrpD family protein
C1S65_RS22875	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS22880	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C1S65_RS22885	COG0583	DNA-binding transcription factor activity
C1S65_RS22920	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS22925	COG1177	transmembrane transport
C1S65_RS22930	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1S65_RS22935	COG3842	ATPase activity
C1S65_RS22945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1S65_RS22950	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS22955	COG0583	DNA-binding transcription factor activity
C1S65_RS22960	COG0840	transmembrane signaling receptor activity
C1S65_RS22970	COG0583	DNA-binding transcription factor activity
C1S65_RS22975	COG1301	dicarboxylic acid transport
C1S65_RS22980	COG0165	Argininosuccinate lyase
C1S65_RS22990	COG2831	hemolysin activation secretion protein
C1S65_RS23000	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
C1S65_RS23015	COG1414	Transcriptional regulator
C1S65_RS23025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S65_RS23025	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S65_RS23030	COG1177	transmembrane transport
C1S65_RS23035	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1S65_RS23040	COG3842	ATPase activity
C1S65_RS23055	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS23085	COG0569	domain protein
C1S65_RS23085	COG0189	ligase activity
C1S65_RS23105	COG2186	Transcriptional regulator
C1S65_RS23135	COG2885	chlorophyll binding
C1S65_RS23135	COG3047	cAMP biosynthetic process
C1S65_RS23140	COG2199	diguanylate cyclase activity
C1S65_RS23150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1S65_RS23155	COG1074	ATP-dependent DNA helicase activity
C1S65_RS23160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1S65_RS23205	COG1309	transcriptional regulator
C1S65_RS23210	COG1739	Uncharacterized protein family UPF0029
C1S65_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS23225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1S65_RS23240	COG2814	Major facilitator Superfamily
C1S65_RS23255	COG2217	Heavy metal translocating P-type atpase
C1S65_RS23265	COG0840	transmembrane signaling receptor activity
C1S65_RS23275	COG2207	Transcriptional regulator
C1S65_RS23285	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS23300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S65_RS23370	COG4964	Belongs to the GSP D family
C1S65_RS23400	COG4953	penicillin-binding protein 1C
C1S65_RS23410	COG2373	Large extracellular alpha-helical protein
C1S65_RS23415	COG0534	Mate efflux family protein
C1S65_RS23420	COG1166	arginine decarboxylase activity
C1S65_RS23425	COG0023	Translation Initiation Factor
C1S65_RS23455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1S65_RS23475	COG2264	protein methyltransferase activity
C1S65_RS23490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1S65_RS23500	COG0138	bifunctional purine biosynthesis protein purh
C1S65_RS23505	COG0151	Belongs to the GarS family
C1S65_RS23540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S65_RS23550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C1S65_RS23565	COG0330	HflC and HflK could
C1S65_RS23585	COG4774	siderophore transport
C1S65_RS23595	COG1113	amino acid transport
C1S65_RS23625	COG0411	ABC transporter
C1S65_RS23645	COG0789	Transcriptional regulator
C1S65_RS23650	COG0484	heat shock protein binding
C1S65_RS23655	COG0443	Heat shock 70 kDa protein
C1S65_RS23675	COG0697	spore germination
C1S65_RS23680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1S65_RS23695	COG0596	Alpha beta hydrolase
C1S65_RS23705	COG2982	Protein involved in outer membrane biogenesis
C1S65_RS23730	COG4221	oxidoreductase activity
C1S65_RS23765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1S65_RS23770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1S65_RS23790	COG1032	radical SAM domain protein
C1S65_RS23800	COG0305	Participates in initiation and elongation during chromosome replication
C1S65_RS23805	COG0359	binds to the 23S rRNA
C1S65_RS23815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1S65_RS23820	COG0360	Binds together with S18 to 16S ribosomal RNA
C1S65_RS23825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S65_RS23830	COG0557	exoribonuclease II activity
C1S65_RS23850	COG1178	ABC-type Fe3 transport system permease component
C1S65_RS23865	COG1028	Short-chain dehydrogenase reductase Sdr
C1S65_RS23870	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S65_RS23870	COG1902	pentaerythritol trinitrate reductase activity
C1S65_RS23885	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1S65_RS23890	COG3916	Acyl-homoserine-lactone synthase
C1S65_RS23895	COG2197	response regulator
C1S65_RS23900	COG0840	transmembrane signaling receptor activity
C1S65_RS23905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1S65_RS23910	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C1S65_RS23915	COG0330	HflC and HflK could
C1S65_RS23920	COG0330	HflC and HflK could
C1S65_RS23925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1S65_RS23930	COG1923	regulation of RNA biosynthetic process
C1S65_RS23935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1S65_RS23940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1S65_RS23945	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1S65_RS23950	COG0802	atpase or kinase
C1S65_RS23955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1S65_RS23955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1S65_RS23965	COG2860	membrane
C1S65_RS23970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1S65_RS23975	COG1162	GTPase activity
C1S65_RS23985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1S65_RS24000	COG0688	phosphatidylethanolamine metabolic process
C1S65_RS24005	COG3830	Belongs to the UPF0237 family
C1S65_RS24005	COG0560	Phosphoserine phosphatase
C1S65_RS24025	COG3577	Aspartyl protease
C1S65_RS24040	COG3150	esterase
C1S65_RS24045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1S65_RS24055	COG0494	nUDIX hydrolase
C1S65_RS24070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1S65_RS24075	COG1538	Outer membrane efflux protein
C1S65_RS24085	COG1519	Transferase
C1S65_RS24105	COG0667	Aldo Keto reductase
C1S65_RS24115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1S65_RS24115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1S65_RS24120	COG1132	(ABC) transporter
C1S65_RS24135	COG0438	transferase activity, transferring glycosyl groups
C1S65_RS24160	COG0438	transferase activity, transferring glycosyl groups
C1S65_RS24165	COG2192	nodulation
C1S65_RS24170	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1S65_RS24175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S65_RS24180	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1S65_RS24180	COG0506	proline dehydrogenase activity
C1S65_RS24180	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1S65_RS24190	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS24200	COG0312	modulator of DNA gyrase
C1S65_RS24205	COG0477	Major facilitator Superfamily
C1S65_RS24210	COG0513	Belongs to the DEAD box helicase family
C1S65_RS24215	COG2081	HI0933 family
C1S65_RS24220	COG1289	transmembrane transporter activity
C1S65_RS24235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1S65_RS24250	COG1451	nucleotide metabolic process
C1S65_RS24255	COG1917	Cupin 2, conserved barrel domain protein
C1S65_RS24255	COG2207	Transcriptional regulator
C1S65_RS24265	COG1175	transmembrane transport
C1S65_RS24285	COG0246	Mannitol dehydrogenase
C1S65_RS24290	COG1070	Carbohydrate kinase
C1S65_RS24305	COG5001	Diguanylate cyclase
C1S65_RS24305	COG3300	MHYT domain
C1S65_RS24325	COG0126	phosphoglycerate kinase activity
C1S65_RS24330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S65_RS24335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1S65_RS24340	COG0640	Transcriptional regulator
C1S65_RS24345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1S65_RS24350	COG1422	Protein of unknown function (DUF1090)
C1S65_RS24385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1S65_RS24390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1S65_RS24405	COG2353	YceI-like domain
C1S65_RS24410	COG3038	cytochrome b561
C1S65_RS24425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1S65_RS24430	COG1272	protein, Hemolysin III
C1S65_RS24440	COG2198	Histidine kinase
C1S65_RS24440	COG0643	Histidine kinase
C1S65_RS24440	COG0784	Response regulator, receiver
C1S65_RS24465	COG0189	ligase activity
C1S65_RS24475	COG1678	Uncharacterized ACR, COG1678
C1S65_RS24480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1S65_RS24485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1S65_RS24490	COG0540	Belongs to the ATCase OTCase family
C1S65_RS24495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1S65_RS24500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1S65_RS24505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1S65_RS24550	COG2226	methyltransferase
C1S65_RS24560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S65_RS24565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1S65_RS24570	COG0140	phosphoribosyl-ATP diphosphatase activity
C1S65_RS24575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S65_RS24580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S65_RS24595	COG0840	transmembrane signaling receptor activity
C1S65_RS24600	COG0840	transmembrane signaling receptor activity
C1S65_RS24605	COG1126	abc transporter atp-binding protein
C1S65_RS24610	COG0765	amino acid transport
C1S65_RS24620	COG2943	transferase activity, transferring hexosyl groups
C1S65_RS24625	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1S65_RS24630	COG1490	D-aminoacyl-tRNA deacylase activity
C1S65_RS24650	COG1228	amidohydrolase
C1S65_RS24655	COG1113	amino acid transport
C1S65_RS24660	COG2986	histidine ammonia-lyase
C1S65_RS24665	COG2986	histidine ammonia-lyase
C1S65_RS24670	COG0517	IMP dehydrogenase activity
C1S65_RS24670	COG4175	Glycine betaine
C1S65_RS24675	COG4176	ABC-type proline glycine betaine transport system permease component
C1S65_RS24685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1S65_RS24695	COG2188	Transcriptional regulator
C1S65_RS24700	COG0402	S-adenosylhomocysteine deaminase activity
C1S65_RS24725	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1S65_RS24730	COG0058	SHG alpha-glucan phosphorylase activity
C1S65_RS24740	COG1217	gtp-binding protein TYPA
C1S65_RS24745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1S65_RS24745	COG0301	tRNA thio-modification
C1S65_RS24760	COG3852	Histidine kinase
C1S65_RS24775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1S65_RS24815	COG3655	Transcriptional regulator
C1S65_RS24855	COG2026	Addiction module toxin, RelE StbE family
C1S65_RS24875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S65_RS24880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C1S65_RS24885	COG0640	Transcriptional regulator
C1S65_RS24935	COG1136	(ABC) transporter
C1S65_RS24940	COG2815	serine threonine protein kinase
C1S65_RS24940	COG0515	serine threonine protein kinase
C1S65_RS24960	COG1360	Flagellar Motor Protein
C1S65_RS25030	COG3209	COG3209 Rhs family protein
C1S65_RS25055	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1S65_RS25065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1S65_RS25070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1S65_RS25075	COG4942	peptidase
C1S65_RS25080	COG0793	Belongs to the peptidase S41A family
C1S65_RS25085	COG2861	carbohydrate metabolic process
C1S65_RS25095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S65_RS25100	COG1309	transcriptional regulator
C1S65_RS25105	COG1012	belongs to the aldehyde dehydrogenase family
C1S65_RS25110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C1S65_RS25115	COG3263	regulation of cellular component size
C1S65_RS25120	COG1196	nuclear chromosome segregation
C1S65_RS25120	COG3264	Mechanosensitive ion channel
C1S65_RS25125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1S65_RS25130	COG3118	belongs to the thioredoxin family
C1S65_RS25135	COG1192	Involved in chromosome partitioning
C1S65_RS25140	COG0583	DNA-binding transcription factor activity
C1S65_RS25145	COG2814	Major facilitator Superfamily
C1S65_RS25210	COG3397	chitin binding
C1S65_RS25215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1S65_RS25220	COG0493	'glutamate synthase
C1S65_RS25225	COG0067	glutamate synthase
C1S65_RS25225	COG0069	glutamate synthase activity
C1S65_RS25225	COG0070	glutamate synthase
C1S65_RS25235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1S65_RS25240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1S65_RS25270	COG0281	malic enzyme
C1S65_RS25280	COG0254	rRNA binding
C1S65_RS25285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1S65_RS25290	COG0018	arginyl-trna synthetase
C1S65_RS25305	COG0791	NLP P60 protein
C1S65_RS25330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S65_RS25335	COG2813	Specifically methylates the guanine in position
C1S65_RS25335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S65_RS25345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1S65_RS25350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1S65_RS25360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1S65_RS25365	COG2022	thiamine diphosphate biosynthetic process
C1S65_RS25375	COG2363	Small membrane protein
C1S65_RS25380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S65_RS25390	COG2177	Part of the ABC transporter FtsEX involved in
C1S65_RS25395	COG2884	Cell division ATP-binding protein ftsE
C1S65_RS25400	COG0552	protein localization to endoplasmic reticulum
C1S65_RS25410	COG0612	Peptidase, M16
C1S65_RS25415	COG0612	Peptidase, M16
C1S65_RS25420	COG0742	ribosomal rna small subunit methyltransferase
C1S65_RS25425	COG0612	Peptidase, M16
C1S65_RS25440	COG1309	transcriptional regulator
C1S65_RS25450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1S65_RS25455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1S65_RS25460	COG0405	Gamma-glutamyltransferase
C1S65_RS25465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1S65_RS25475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1S65_RS25480	COG2239	Acts as a magnesium transporter
C1S65_RS25485	COG0129	dihydroxy-acid dehydratase activity
C1S65_RS25495	COG1823	symporter activity
C1S65_RS25510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1S65_RS25520	COG1840	ABC-type Fe3 transport system, periplasmic component
C1S65_RS25525	COG1178	ABC-type Fe3 transport system permease component
C1S65_RS25530	COG3842	ATPase activity
C1S65_RS25545	COG0789	Transcriptional regulator
C1S65_RS25550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1S65_RS25555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1S65_RS25560	COG0730	response to heat
C1S65_RS25570	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C1S65_RS25575	COG0494	nUDIX hydrolase
C1S65_RS25590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1S65_RS25595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1S65_RS25600	COG3204	pilus organization
C1S65_RS25605	COG3204	pilus organization
C1S65_RS25610	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1S65_RS25615	COG0277	FAD linked oxidase domain protein
C1S65_RS25620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S65_RS25630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS25635	COG1683	Conserved Protein
C1S65_RS25670	COG2267	carboxylic ester hydrolase activity
C1S65_RS25675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S65_RS25680	COG1126	abc transporter atp-binding protein
C1S65_RS25685	COG0765	amino acid transport
C1S65_RS25690	COG0765	amino acid transport
C1S65_RS25700	COG3829	transcription factor binding
C1S65_RS25725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1S65_RS25730	COG4208	sulfate ABC transporter
C1S65_RS25740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1S65_RS25755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS25760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS25770	COG1177	transmembrane transport
C1S65_RS25775	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1S65_RS25780	COG3842	ATPase activity
C1S65_RS25800	COG0174	glutamine synthetase
C1S65_RS25805	COG0174	glutamine synthetase
C1S65_RS25810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1S65_RS25810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1S65_RS25825	COG1522	sequence-specific DNA binding
C1S65_RS25845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S65_RS25845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S65_RS25850	COG0840	transmembrane signaling receptor activity
C1S65_RS25860	COG1566	PFAM secretion protein HlyD family protein
C1S65_RS25870	COG1289	transmembrane transporter activity
C1S65_RS25890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S65_RS25905	COG2175	clavaminate synthase activity
C1S65_RS25910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1S65_RS25935	COG2200	EAL domain
C1S65_RS25935	COG2199	diguanylate cyclase activity
C1S65_RS25945	COG1802	Transcriptional regulator
C1S65_RS26010	COG1960	acyl-CoA dehydrogenase activity
C1S65_RS26015	COG0583	DNA-binding transcription factor activity
C1S65_RS26040	COG0427	acetyl-CoA hydrolase
C1S65_RS26075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1S65_RS26080	COG1561	YicC-like family, N-terminal region
C1S65_RS26085	COG0194	GDP metabolic process
C1S65_RS26095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1S65_RS26100	COG0174	glutamine synthetase
C1S65_RS26110	COG1758	RNA polymerase activity
C1S65_RS26115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S65_RS26145	COG0848	biopolymer transport protein
C1S65_RS26155	COG0583	DNA-binding transcription factor activity
C1S65_RS26160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1S65_RS26190	COG3161	chorismate lyase activity
C1S65_RS26195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1S65_RS26215	COG1253	flavin adenine dinucleotide binding
C1S65_RS26220	COG0739	heme binding
C1S65_RS26230	COG0704	Plays a role in the regulation of phosphate uptake
C1S65_RS26235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S65_RS26240	COG0581	inorganic phosphate transmembrane transporter activity
C1S65_RS26255	COG0477	Major facilitator Superfamily
C1S65_RS26260	COG1607	acyl-coa hydrolase
C1S65_RS26290	COG0583	DNA-binding transcription factor activity
C1S65_RS26295	COG1027	Aspartate ammonia-lyase
C1S65_RS26335	COG0511	ligase activity, forming carbon-carbon bonds
C1S65_RS26335	COG5016	pyruvate
C1S65_RS26340	COG0439	Biotin carboxylase
C1S65_RS26345	COG0583	DNA-binding transcription factor activity
C1S65_RS26360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1S65_RS26365	COG5001	Diguanylate cyclase
C1S65_RS26370	COG0210	DNA helicase
C1S65_RS26385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S65_RS26385	COG4651	solute:proton antiporter activity
C1S65_RS26390	COG1607	acyl-coa hydrolase
C1S65_RS26395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1S65_RS26405	COG0523	cobalamin synthesis protein
C1S65_RS26425	COG1469	GTP cyclohydrolase I activity
C1S65_RS26435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1S65_RS26440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S65_RS26445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S65_RS26465	COG1113	amino acid transport
C1S65_RS26470	COG1335	isochorismatase
C1S65_RS26475	COG0583	DNA-binding transcription factor activity
C1S65_RS26480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1S65_RS26485	COG1349	DNA-binding transcription factor activity
C1S65_RS26490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1S65_RS26495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1S65_RS26500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1S65_RS26505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1S65_RS26510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1S65_RS26515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1S65_RS26520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1S65_RS26530	COG0356	it plays a direct role in the translocation of protons across the membrane
C1S65_RS26535	COG3312	ion transport
C1S65_RS26540	COG1475	DNA binding
C1S65_RS26545	COG1192	Involved in chromosome partitioning
C1S65_RS26550	COG0357	Ribosomal RNA small subunit methyltransferase G
C1S65_RS26555	COG0445	tRNA wobble uridine modification
C1S65_RS26560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1S65_RS26565	COG0706	membrane insertase activity
C1S65_RS26570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1S65_RS26575	COG0594	ribonuclease P activity
C1S65_RS26580	COG0230	Belongs to the bacterial ribosomal protein bL34 family