locus-tag	class	description
PPS_RS00005	COG1475	DNA binding
PPS_RS00010	COG1192	Involved in chromosome partitioning
PPS_RS00015	COG0357	Ribosomal RNA small subunit methyltransferase G
PPS_RS00020	COG0445	tRNA wobble uridine modification
PPS_RS00025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPS_RS00030	COG0706	membrane insertase activity
PPS_RS00040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PPS_RS00045	COG0592	DNA-directed DNA polymerase activity
PPS_RS00050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPS_RS00055	COG0187	DNA topoisomerase II activity
PPS_RS00090	COG0477	Major facilitator Superfamily
PPS_RS00100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PPS_RS00105	COG0751	glycine-tRNA ligase activity
PPS_RS00110	COG0752	glycyl-tRNA synthetase alpha subunit
PPS_RS00115	COG2818	Glycosylase
PPS_RS00130	COG0569	domain protein
PPS_RS00135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPS_RS00140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PPS_RS00145	COG0242	peptide deformylase activity
PPS_RS00150	COG0758	DNA mediated transformation
PPS_RS00155	COG0009	L-threonylcarbamoyladenylate synthase
PPS_RS00170	COG0408	coproporphyrinogen oxidase activity
PPS_RS00175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPS_RS00180	COG0659	secondary active sulfate transmembrane transporter activity
PPS_RS00190	COG3119	arylsulfatase activity
PPS_RS00210	COG0159	tryptophan synthase activity
PPS_RS00215	COG0133	tryptophan synthase activity
PPS_RS00230	COG3360	Dodecin
PPS_RS00240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPS_RS00245	COG1764	response to oxidative stress
PPS_RS00275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PPS_RS00280	COG0339	signal peptide processing
PPS_RS00285	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PPS_RS00290	COG0339	signal peptide processing
PPS_RS00305	COG0659	secondary active sulfate transmembrane transporter activity
PPS_RS00315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PPS_RS00320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PPS_RS00325	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PPS_RS00340	COG3346	SURF1 family
PPS_RS00350	COG1612	heme a metabolic process
PPS_RS00355	COG0109	protoheme IX farnesyltransferase activity
PPS_RS00370	COG2011	ABC-type metal ion transport system permease component
PPS_RS00375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPS_RS00390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPS_RS00395	COG1121	(ABC) transporter
PPS_RS00400	COG0735	belongs to the Fur family
PPS_RS00405	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PPS_RS00430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PPS_RS00435	COG3245	cytochrome
PPS_RS00445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PPS_RS00460	COG3023	N-Acetylmuramoyl-L-alanine amidase
PPS_RS00465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PPS_RS00470	COG5002	protein histidine kinase activity
PPS_RS00475	COG2204	response regulator
PPS_RS00500	COG1301	dicarboxylic acid transport
PPS_RS00505	COG0700	Nucleoside recognition
PPS_RS00520	COG1127	ABC transporter
PPS_RS00525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PPS_RS00540	COG1283	sodium-dependent phosphate transmembrane transporter activity
PPS_RS00545	COG0861	Integral membrane protein TerC family
PPS_RS00550	COG2851	Citrate transporter
PPS_RS00585	COG0427	acetyl-CoA hydrolase
PPS_RS00605	COG0583	DNA-binding transcription factor activity
PPS_RS00610	COG1960	acyl-CoA dehydrogenase activity
PPS_RS00655	COG1802	Transcriptional regulator
PPS_RS00665	COG3300	MHYT domain
PPS_RS00665	COG5001	Diguanylate cyclase
PPS_RS00675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS00695	COG3039	Transposase
PPS_RS00710	COG2175	clavaminate synthase activity
PPS_RS00725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPS_RS00745	COG1289	transmembrane transporter activity
PPS_RS00755	COG1566	PFAM secretion protein HlyD family protein
PPS_RS00775	COG0672	)-iron permease
PPS_RS00790	COG0625	glutathione transferase activity
PPS_RS00795	COG0165	Argininosuccinate lyase
PPS_RS00805	COG0181	hydroxymethylbilane synthase activity
PPS_RS00825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PPS_RS00855	COG0488	(ABC) transporter
PPS_RS00860	COG1280	lysine exporter protein (LysE YggA)
PPS_RS00930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PPS_RS00940	COG1136	(ABC) transporter
PPS_RS00975	COG2188	Transcriptional regulator
PPS_RS00980	COG1053	succinate dehydrogenase
PPS_RS00995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPS_RS01020	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PPS_RS01035	COG0745	RESPONSE REGULATOR receiver
PPS_RS01040	COG2199	diguanylate cyclase activity
PPS_RS01055	COG2011	ABC-type metal ion transport system permease component
PPS_RS01060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPS_RS01065	COG1464	Belongs to the NlpA lipoprotein family
PPS_RS01090	COG1126	abc transporter atp-binding protein
PPS_RS01095	COG0765	amino acid transport
PPS_RS01100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS01105	COG1045	serine acetyltransferase
PPS_RS01110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PPS_RS01115	COG2175	clavaminate synthase activity
PPS_RS01120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPS_RS01125	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PPS_RS01130	COG4521	taurine ABC transporter
PPS_RS01140	COG0450	alkyl hydroperoxide reductase
PPS_RS01145	COG0431	NADPH-dependent FMN reductase
PPS_RS01150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPS_RS01155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPS_RS01160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPS_RS01165	COG1116	anion transmembrane transporter activity
PPS_RS01180	COG2918	glutathione biosynthetic process
PPS_RS01190	COG2183	response to ionizing radiation
PPS_RS01205	COG0189	ligase activity
PPS_RS01210	COG0189	ligase activity
PPS_RS01210	COG4067	protein conserved in archaea
PPS_RS01215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PPS_RS01225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PPS_RS01230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PPS_RS01245	COG0243	molybdopterin cofactor binding
PPS_RS01250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PPS_RS01255	COG1652	LysM domain
PPS_RS01260	COG1011	Hydrolase
PPS_RS01265	COG0494	nUDIX hydrolase
PPS_RS01270	COG1218	3'(2'),5'-bisphosphate nucleotidase
PPS_RS01295	COG2957	Belongs to the agmatine deiminase family
PPS_RS01310	COG0069	glutamate synthase activity
PPS_RS01335	COG2801	Transposase and inactivated derivatives
PPS_RS01370	COG4215	(ABC) transporter
PPS_RS01405	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PPS_RS01420	COG2223	nitrite transmembrane transporter activity
PPS_RS01425	COG0131	Imidazoleglycerol-phosphate dehydratase
PPS_RS01430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PPS_RS01440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PPS_RS01445	COG0107	imidazoleglycerol-phosphate synthase activity
PPS_RS01450	COG4175	Glycine betaine
PPS_RS01455	COG4176	ABC-type proline glycine betaine transport system permease component
PPS_RS01465	COG1760	l-serine dehydratase
PPS_RS01485	COG1250	3-hydroxyacyl-CoA dehydrogenase
PPS_RS01490	COG3246	L-lysine catabolic process to acetate
PPS_RS01540	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPS_RS01540	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS01545	COG0247	lactate metabolic process
PPS_RS01545	COG2181	nitrate reductase activity
PPS_RS01550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PPS_RS01570	COG1017	nitric oxide dioxygenase activity
PPS_RS01570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PPS_RS01590	COG0840	transmembrane signaling receptor activity
PPS_RS01600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PPS_RS01635	COG1063	alcohol dehydrogenase
PPS_RS01640	COG3039	Transposase
PPS_RS01650	COG0531	amino acid
PPS_RS01655	COG0204	Acyl-transferase
PPS_RS01665	COG0745	RESPONSE REGULATOR receiver
PPS_RS01670	COG2205	protein histidine kinase activity
PPS_RS01675	COG4452	Inner membrane protein CreD
PPS_RS01685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPS_RS01705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PPS_RS01720	COG0438	transferase activity, transferring glycosyl groups
PPS_RS01760	COG4774	siderophore transport
PPS_RS01765	COG3712	iron ion homeostasis
PPS_RS01770	COG1595	DNA-templated transcription, initiation
PPS_RS01775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPS_RS01790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PPS_RS01810	COG3585	molybdate ion transport
PPS_RS01810	COG2005	Transcriptional regulator
PPS_RS01815	COG1040	competence protein
PPS_RS01820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPS_RS01825	COG0156	8-amino-7-oxononanoate synthase activity
PPS_RS01850	COG1960	acyl-CoA dehydrogenase activity
PPS_RS01855	COG3706	GGDEF domain
PPS_RS01860	COG1960	acyl-CoA dehydrogenase activity
PPS_RS01865	COG0583	DNA-binding transcription factor activity
PPS_RS01870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PPS_RS01885	COG0535	radical SAM domain protein
PPS_RS01895	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PPS_RS01900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPS_RS01905	COG1025	Belongs to the peptidase M16 family
PPS_RS01910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPS_RS01955	COG0358	DNA primase activity
PPS_RS01960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PPS_RS01965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PPS_RS01970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PPS_RS01975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PPS_RS01985	COG0617	tRNA 3'-terminal CCA addition
PPS_RS01990	COG2719	SpoVR family
PPS_RS01995	COG2718	Belongs to the UPF0229 family
PPS_RS02000	COG2766	serine protein kinase
PPS_RS02005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPS_RS02010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPS_RS02015	COG2967	ApaG domain
PPS_RS02020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PPS_RS02025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PPS_RS02030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPS_RS02035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PPS_RS02040	COG3178	'Phosphotransferase
PPS_RS02045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PPS_RS02050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PPS_RS02060	COG4585	Histidine kinase
PPS_RS02065	COG2197	response regulator
PPS_RS02070	COG3842	ATPase activity
PPS_RS02080	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPS_RS02090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PPS_RS02095	COG0546	phosphoglycolate phosphatase activity
PPS_RS02100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PPS_RS02110	COG4625	pathogenesis
PPS_RS02110	COG3240	lipase activity
PPS_RS02115	COG0512	Glutamine amidotransferase of anthranilate synthase
PPS_RS02120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPS_RS02125	COG0134	indole-3-glycerol-phosphate synthase activity
PPS_RS02140	COG1765	OsmC-like protein
PPS_RS02150	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PPS_RS02155	COG0537	adenosine 5'-monophosphoramidase activity
PPS_RS02160	COG0300	oxidoreductase activity
PPS_RS02170	COG1981	membrane
PPS_RS02175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PPS_RS02180	COG0316	Belongs to the HesB IscA family
PPS_RS02185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PPS_RS02190	COG0739	heme binding
PPS_RS02195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PPS_RS02215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PPS_RS02215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PPS_RS02220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PPS_RS02245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PPS_RS02265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PPS_RS02270	COG0081	regulation of translation
PPS_RS02275	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PPS_RS02280	COG0222	ribosome binding
PPS_RS02285	COG0085	RNA polymerase activity
PPS_RS02290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PPS_RS02295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PPS_RS02300	COG0049	tRNA binding
PPS_RS02305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPS_RS02310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PPS_RS02320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PPS_RS02325	COG0088	Forms part of the polypeptide exit tunnel
PPS_RS02330	COG0089	rRNA binding
PPS_RS02335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PPS_RS02340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PPS_RS02345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PPS_RS02350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PPS_RS02355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PPS_RS02360	COG0255	Belongs to the universal ribosomal protein uL29 family
PPS_RS02365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PPS_RS02370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PPS_RS02375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PPS_RS02380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PPS_RS02385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PPS_RS02390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PPS_RS02395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PPS_RS02400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PPS_RS02405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PPS_RS02410	COG1841	ribosomal large subunit assembly
PPS_RS02415	COG0200	Binds to the 23S rRNA
PPS_RS02425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PPS_RS02430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PPS_RS02435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PPS_RS02440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PPS_RS02445	COG0202	RNA polymerase activity
PPS_RS02450	COG0203	ribosomal protein L17
PPS_RS02455	COG0753	catalase activity
PPS_RS02460	COG2193	ferroxidase activity
PPS_RS02465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PPS_RS02470	COG2814	Major facilitator Superfamily
PPS_RS02475	COG0629	single-stranded DNA binding
PPS_RS02480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS02485	COG0730	response to heat
PPS_RS02490	COG4221	oxidoreductase activity
PPS_RS02495	COG0243	molybdopterin cofactor binding
PPS_RS02495	COG3383	formate dehydrogenase (NAD+) activity
PPS_RS02500	COG0243	molybdopterin cofactor binding
PPS_RS02500	COG3383	formate dehydrogenase (NAD+) activity
PPS_RS02505	COG0437	4 iron, 4 sulfur cluster binding
PPS_RS02510	COG2864	formate dehydrogenase
PPS_RS02515	COG3058	Necessary for formate dehydrogenase activity
PPS_RS02520	COG1921	L-seryl-tRNASec selenium transferase activity
PPS_RS02525	COG3276	selenocysteine insertion sequence binding
PPS_RS02535	COG0252	asparaginase activity
PPS_RS02540	COG1115	amino acid carrier protein
PPS_RS02565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPS_RS02575	COG2814	Major facilitator Superfamily
PPS_RS02580	COG3047	cAMP biosynthetic process
PPS_RS02610	COG3118	belongs to the thioredoxin family
PPS_RS02615	COG2264	protein methyltransferase activity
PPS_RS02625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PPS_RS02630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PPS_RS02630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PPS_RS02645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PPS_RS02650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPS_RS02655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PPS_RS02660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PPS_RS02670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPS_RS02680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPS_RS02685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PPS_RS02690	COG0142	geranyltranstransferase activity
PPS_RS02695	COG1722	exodeoxyribonuclease VII activity
PPS_RS02700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPS_RS02705	COG1690	Belongs to the RtcB family
PPS_RS02715	COG0579	oxidoreductase
PPS_RS02735	COG2132	Multicopper oxidase
PPS_RS02745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PPS_RS02750	COG3228	Belongs to the MtfA family
PPS_RS02755	COG0586	Pfam SNARE associated Golgi protein
PPS_RS02760	COG0456	acetyltransferase
PPS_RS02765	COG4302	ethanolamine ammonia-lyase activity
PPS_RS02770	COG4303	Ethanolamine ammonia lyase large subunit
PPS_RS02775	COG0531	amino acid
PPS_RS02785	COG3284	Transcriptional regulator
PPS_RS02790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPS_RS02805	COG0702	epimerase
PPS_RS02815	COG1063	alcohol dehydrogenase
PPS_RS02825	COG0022	dehydrogenase e1 component
PPS_RS02830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PPS_RS02835	COG3199	ATP-NAD kinase
PPS_RS02840	COG3284	Transcriptional regulator
PPS_RS02855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PPS_RS02865	COG3328	transposase activity
PPS_RS02890	COG0023	Translation Initiation Factor
PPS_RS02895	COG1166	arginine decarboxylase activity
PPS_RS02905	COG0534	Mate efflux family protein
PPS_RS02910	COG2373	Large extracellular alpha-helical protein
PPS_RS02920	COG4953	penicillin-binding protein 1C
PPS_RS02950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPS_RS02960	COG2030	dehydratase
PPS_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS02975	COG2207	Transcriptional regulator
PPS_RS02980	COG0840	transmembrane signaling receptor activity
PPS_RS02990	COG2217	Heavy metal translocating P-type atpase
PPS_RS03005	COG2814	Major facilitator Superfamily
PPS_RS03015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PPS_RS03020	COG0300	oxidoreductase activity
PPS_RS03025	COG1739	Uncharacterized protein family UPF0029
PPS_RS03030	COG1309	transcriptional regulator
PPS_RS03065	COG2995	paraquat-inducible protein a
PPS_RS03070	COG2995	paraquat-inducible protein a
PPS_RS03075	COG3008	intermembrane lipid transfer
PPS_RS03080	COG0268	Binds directly to 16S ribosomal RNA
PPS_RS03090	COG0196	riboflavin kinase activity
PPS_RS03095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PPS_RS03100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PPS_RS03105	COG1047	Peptidyl-prolyl cis-trans
PPS_RS03110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PPS_RS03140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS03165	COG0542	response to heat
PPS_RS03195	COG1252	NADH dehydrogenase
PPS_RS03220	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PPS_RS03225	COG0237	dephospho-CoA kinase activity
PPS_RS03250	COG0582	viral genome integration into host DNA
PPS_RS03310	COG2963	transposase activity
PPS_RS03315	COG2801	Transposase and inactivated derivatives
PPS_RS03335	COG0583	DNA-binding transcription factor activity
PPS_RS03360	COG4191	Histidine kinase
PPS_RS03365	COG0039	L-malate dehydrogenase activity
PPS_RS03370	COG0765	amino acid transport
PPS_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS03385	COG0626	cystathionine gamma-synthase activity
PPS_RS03390	COG0833	amino acid
PPS_RS03395	COG0583	DNA-binding transcription factor activity
PPS_RS03405	COG1522	sequence-specific DNA binding
PPS_RS03415	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS03430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PPS_RS03445	COG0488	(ABC) transporter
PPS_RS03450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PPS_RS03480	COG1067	ATP-dependent peptidase activity
PPS_RS03490	COG2862	Uncharacterized protein family, UPF0114
PPS_RS03500	COG0545	Peptidyl-prolyl cis-trans isomerase
PPS_RS03510	COG2824	Alkylphosphonate utilization operon protein PhnA
PPS_RS03515	COG0142	geranyltranstransferase activity
PPS_RS03520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PPS_RS03525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PPS_RS03530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPS_RS03535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PPS_RS03540	COG3045	CreA protein
PPS_RS03565	COG0456	acetyltransferase
PPS_RS03600	COG2223	nitrite transmembrane transporter activity
PPS_RS03615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPS_RS03615	COG2169	Transcriptional regulator
PPS_RS03620	COG3264	Mechanosensitive ion channel
PPS_RS03620	COG1511	domain protein
PPS_RS03655	COG1126	abc transporter atp-binding protein
PPS_RS03660	COG0765	amino acid transport
PPS_RS03665	COG0765	amino acid transport
PPS_RS03670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS03675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS03680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PPS_RS03685	COG2423	ornithine cyclodeaminase activity
PPS_RS03690	COG0006	proline dipeptidase activity
PPS_RS03695	COG3608	succinylglutamate desuccinylase aspartoacylase
PPS_RS03700	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS03705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PPS_RS03710	COG1335	isochorismatase
PPS_RS03725	COG0628	permease
PPS_RS03775	COG2963	transposase activity
PPS_RS03785	COG2433	Pfam Transposase IS66
PPS_RS03810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPS_RS03840	COG0640	Transcriptional regulator
PPS_RS03845	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS03850	COG0604	alcohol dehydrogenase
PPS_RS03870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPS_RS03870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PPS_RS03895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPS_RS03900	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS03910	COG0583	DNA-binding transcription factor activity
PPS_RS03915	COG4221	oxidoreductase activity
PPS_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS03950	COG0604	alcohol dehydrogenase
PPS_RS03950	COG3321	synthase
PPS_RS03955	COG0582	viral genome integration into host DNA
PPS_RS03960	COG0012	GTP binding
PPS_RS03965	COG0193	aminoacyl-tRNA hydrolase activity
PPS_RS03970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PPS_RS03975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PPS_RS03985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PPS_RS03990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PPS_RS04000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPS_RS04005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PPS_RS04010	COG3848	Pyruvate phosphate dikinase
PPS_RS04010	COG0574	Belongs to the PEP-utilizing enzyme family
PPS_RS04040	COG3039	Transposase
PPS_RS04055	COG3039	Transposase
PPS_RS04060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PPS_RS04065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PPS_RS04075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPS_RS04080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPS_RS04095	COG0415	Belongs to the DNA photolyase family
PPS_RS04100	COG0789	Transcriptional regulator
PPS_RS04105	COG3272	Protein of unknown function (DUF1722)
PPS_RS04110	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PPS_RS04115	COG1090	epimerase
PPS_RS04120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PPS_RS04130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PPS_RS04135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PPS_RS04155	COG0579	oxidoreductase
PPS_RS04190	COG2135	peptidase activity
PPS_RS04200	COG2119	membrane
PPS_RS04205	COG2813	Specifically methylates the guanine in position
PPS_RS04210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPS_RS04215	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS04245	COG2336	PFAM SpoVT AbrB
PPS_RS04255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPS_RS04260	COG2885	chlorophyll binding
PPS_RS04265	COG0857	belongs to the CobB CobQ family
PPS_RS04265	COG0280	phosphate acetyltransferase
PPS_RS04280	COG0386	Belongs to the glutathione peroxidase family
PPS_RS04305	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PPS_RS04310	COG0492	ferredoxin-NADP+ reductase activity
PPS_RS04335	COG0084	hydrolase, TatD family'
PPS_RS04340	COG1609	Transcriptional regulator
PPS_RS04350	COG1105	Belongs to the carbohydrate kinase PfkB family
PPS_RS04355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPS_RS04355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPS_RS04355	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PPS_RS04360	COG3530	Putative quorum-sensing-regulated virulence factor
PPS_RS04370	COG5001	Diguanylate cyclase
PPS_RS04370	COG4251	negative regulation of phosphorylation
PPS_RS04370	COG3706	GGDEF domain
PPS_RS04370	COG2203	Gaf domain
PPS_RS04395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPS_RS04420	COG3604	Transcriptional regulator
PPS_RS04425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PPS_RS04425	COG1017	nitric oxide dioxygenase activity
PPS_RS04430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PPS_RS04435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PPS_RS04440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PPS_RS04445	COG1845	cytochrome c oxidase, subunit III
PPS_RS04450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PPS_RS04455	COG0109	protoheme IX farnesyltransferase activity
PPS_RS04460	COG0436	Aminotransferase
PPS_RS04470	COG0727	PFAM Uncharacterised protein family (UPF0153)
PPS_RS04485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPS_RS04500	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PPS_RS04505	COG0709	Synthesizes selenophosphate from selenide and ATP
PPS_RS04510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PPS_RS04515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PPS_RS04520	COG3639	organic phosphonate transmembrane transporter activity
PPS_RS04525	COG3639	organic phosphonate transmembrane transporter activity
PPS_RS04530	COG3781	membrane
PPS_RS04550	COG2801	Transposase and inactivated derivatives
PPS_RS04555	COG2963	transposase activity
PPS_RS04570	COG0765	amino acid transport
PPS_RS04575	COG0765	amino acid transport
PPS_RS04580	COG0154	amidase activity
PPS_RS04610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PPS_RS04615	COG0343	queuine tRNA-ribosyltransferase activity
PPS_RS04620	COG1862	Preprotein translocase
PPS_RS04635	COG3134	Outer membrane lipoprotein
PPS_RS04650	COG1045	serine acetyltransferase
PPS_RS04660	COG1104	cysteine desulfurase activity
PPS_RS04670	COG0316	Belongs to the HesB IscA family
PPS_RS04675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PPS_RS04680	COG0443	Heat shock 70 kDa protein
PPS_RS04685	COG0633	Ferredoxin
PPS_RS04695	COG0105	UTP biosynthetic process
PPS_RS04700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPS_RS04710	COG1426	Protein conserved in bacteria
PPS_RS04715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PPS_RS04720	COG0124	histidyl-tRNA synthetase
PPS_RS04735	COG1160	GTP binding
PPS_RS04740	COG0436	Aminotransferase
PPS_RS04755	COG4774	siderophore transport
PPS_RS04760	COG3128	pkhd-type hydroxylase
PPS_RS04770	COG0019	diaminopimelate decarboxylase activity
PPS_RS04810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PPS_RS04825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS04835	COG4608	Belongs to the ABC transporter superfamily
PPS_RS04840	COG0444	Belongs to the ABC transporter superfamily
PPS_RS04845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPS_RS04850	COG0601	transmembrane transport
PPS_RS04855	COG0747	negative chemotaxis
PPS_RS04865	COG0747	negative chemotaxis
PPS_RS04870	COG0747	negative chemotaxis
PPS_RS04885	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PPS_RS04895	COG1113	amino acid transport
PPS_RS04900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPS_RS04910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PPS_RS04915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPS_RS04920	COG0154	amidase activity
PPS_RS04925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPS_RS04930	COG1077	Cell shape determining protein MreB Mrl
PPS_RS04935	COG1792	Involved in formation and maintenance of cell shape
PPS_RS04945	COG0424	maF-like protein
PPS_RS04960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPS_RS04965	COG0312	modulator of DNA gyrase
PPS_RS04970	COG3028	Belongs to the UPF0307 family
PPS_RS04975	COG0312	modulator of DNA gyrase
PPS_RS04995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPS_RS05000	COG1660	Displays ATPase and GTPase activities
PPS_RS05010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PPS_RS05015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PPS_RS05020	COG1137	ATPase activity
PPS_RS05025	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PPS_RS05035	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PPS_RS05045	COG1127	ABC transporter
PPS_RS05050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PPS_RS05055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PPS_RS05075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPS_RS05080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PPS_RS05085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PPS_RS05090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPS_RS05095	COG2186	Transcriptional regulator
PPS_RS05100	COG2807	transmembrane transport
PPS_RS05110	COG2801	Transposase and inactivated derivatives
PPS_RS05120	COG2827	Endonuclease containing a URI domain
PPS_RS05125	COG3081	Nucleoid-associated protein
PPS_RS05130	COG0776	regulation of translation
PPS_RS05135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PPS_RS05140	COG0525	valine-tRNA ligase activity
PPS_RS05155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PPS_RS05165	COG0795	lipopolysaccharide-transporting ATPase activity
PPS_RS05170	COG0795	lipopolysaccharide-transporting ATPase activity
PPS_RS05185	COG1278	Cold shock
PPS_RS05190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPS_RS05195	COG1760	l-serine dehydratase
PPS_RS05200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPS_RS05200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPS_RS05205	COG0509	glycine decarboxylation via glycine cleavage system
PPS_RS05230	COG0786	glutamate:sodium symporter activity
PPS_RS05250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PPS_RS05255	COG2235	arginine
PPS_RS05270	COG2832	Protein of unknown function (DUF454)
PPS_RS05335	COG1175	transmembrane transport
PPS_RS05345	COG3842	ATPase activity
PPS_RS05355	COG0676	glucose-6-phosphate 1-epimerase activity
PPS_RS05360	COG1737	Transcriptional regulator
PPS_RS05375	COG0800	Aldolase
PPS_RS05380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPS_RS05385	COG0739	heme binding
PPS_RS05390	COG1570	exodeoxyribonuclease VII activity
PPS_RS05395	COG0583	DNA-binding transcription factor activity
PPS_RS05415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PPS_RS05415	COG0519	Catalyzes the synthesis of GMP from XMP
PPS_RS05420	COG0582	viral genome integration into host DNA
PPS_RS05440	COG3436	PFAM IS66 Orf2 family protein
PPS_RS05505	COG1397	ADP-ribosylglycohydrolase
PPS_RS05510	COG2369	cell adhesion
PPS_RS05520	COG0590	tRNA wobble adenosine to inosine editing
PPS_RS05525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PPS_RS05530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPS_RS05530	COG0047	phosphoribosylformylglycinamidine synthase activity
PPS_RS05545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPS_RS05550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPS_RS05580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPS_RS05645	COG0494	nUDIX hydrolase
PPS_RS05665	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PPS_RS05670	COG0477	Major facilitator Superfamily
PPS_RS05675	COG4536	flavin adenine dinucleotide binding
PPS_RS05685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PPS_RS05690	COG0228	four-way junction DNA binding
PPS_RS05695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PPS_RS05700	COG0336	Belongs to the RNA methyltransferase TrmD family
PPS_RS05705	COG0335	large ribosomal subunit rRNA binding
PPS_RS05710	COG1607	acyl-coa hydrolase
PPS_RS05715	COG4974	Belongs to the 'phage' integrase family
PPS_RS05755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PPS_RS05775	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS05785	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS05790	COG1177	transmembrane transport
PPS_RS05795	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPS_RS05800	COG3842	ATPase activity
PPS_RS05805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PPS_RS05810	COG2979	Protein of unknown function (DUF533)
PPS_RS05815	COG0840	transmembrane signaling receptor activity
PPS_RS05825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPS_RS05825	COG0457	Tetratricopeptide repeat
PPS_RS05840	COG2201	protein-glutamate methylesterase activity
PPS_RS05845	COG2203	Gaf domain
PPS_RS05845	COG3706	GGDEF domain
PPS_RS05845	COG4251	negative regulation of phosphorylation
PPS_RS05845	COG5001	Diguanylate cyclase
PPS_RS05855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PPS_RS05875	COG1073	alpha beta
PPS_RS05885	COG2885	chlorophyll binding
PPS_RS05900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PPS_RS05905	COG0563	adenylate kinase activity
PPS_RS05940	COG0742	ribosomal rna small subunit methyltransferase
PPS_RS05950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS05980	COG2937	Belongs to the GPAT DAPAT family
PPS_RS05995	COG2226	methyltransferase
PPS_RS06000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PPS_RS06005	COG1215	transferase activity, transferring glycosyl groups
PPS_RS06010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PPS_RS06020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PPS_RS06025	COG2171	N-acyltransferase activity
PPS_RS06030	COG1393	Belongs to the ArsC family
PPS_RS06035	COG0025	NhaP-type Na H and K H
PPS_RS06040	COG0436	Aminotransferase
PPS_RS06045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PPS_RS06050	COG0024	Methionine aminopeptidase
PPS_RS06055	COG0052	Belongs to the universal ribosomal protein uS2 family
PPS_RS06060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PPS_RS06065	COG0528	UMP kinase activity
PPS_RS06070	COG0233	cytoplasmic translational termination
PPS_RS06075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PPS_RS06085	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PPS_RS06105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPS_RS06110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPS_RS06115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPS_RS06120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPS_RS06125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PPS_RS06135	COG0825	malonyl-CoA metabolic process
PPS_RS06140	COG0037	tRNA processing
PPS_RS06145	COG0504	CTP synthase activity
PPS_RS06150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PPS_RS06155	COG0148	phosphopyruvate hydratase activity
PPS_RS06165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PPS_RS06175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PPS_RS06185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PPS_RS06190	COG0585	pseudouridine synthase activity
PPS_RS06195	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PPS_RS06200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PPS_RS06215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PPS_RS06220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PPS_RS06415	COG0616	signal peptide processing
PPS_RS06455	COG4386	tail sheath protein
PPS_RS06495	COG3299	homolog of phage Mu protein gp47
PPS_RS06575	COG1546	Belongs to the CinA family
PPS_RS06580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PPS_RS06585	COG2137	regulation of response to DNA damage stimulus
PPS_RS06605	COG3148	PFAM DTW domain containing protein
PPS_RS06620	COG0583	DNA-binding transcription factor activity
PPS_RS06635	COG3091	SprT-like family
PPS_RS06645	COG0037	tRNA processing
PPS_RS06665	COG1393	Belongs to the ArsC family
PPS_RS06685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPS_RS06690	COG2205	protein histidine kinase activity
PPS_RS06690	COG0784	Response regulator, receiver
PPS_RS06690	COG5002	protein histidine kinase activity
PPS_RS06710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPS_RS06715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPS_RS06720	COG3956	TIGRFAM MazG family protein
PPS_RS06725	COG3122	Protein conserved in bacteria
PPS_RS06740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PPS_RS06745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PPS_RS06755	COG0628	permease
PPS_RS06765	COG0791	NLP P60 protein
PPS_RS06770	COG0791	NLP P60 protein
PPS_RS06800	COG1797	cobyrinic acid a,c-diamide synthase activity
PPS_RS06805	COG0778	Nitroreductase
PPS_RS06820	COG1492	cobalamin metabolic process
PPS_RS06830	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PPS_RS06835	COG0406	alpha-ribazole phosphatase activity
PPS_RS06840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PPS_RS06850	COG1846	Transcriptional regulator
PPS_RS06875	COG0583	DNA-binding transcription factor activity
PPS_RS06905	COG2205	protein histidine kinase activity
PPS_RS06910	COG2814	Major facilitator Superfamily
PPS_RS06915	COG0477	Major facilitator Superfamily
PPS_RS06920	COG2076	Multidrug Resistance protein
PPS_RS06925	COG0385	Bile acid
PPS_RS06930	COG2974	May be involved in recombination
PPS_RS06955	COG0024	Methionine aminopeptidase
PPS_RS06960	COG0243	molybdopterin cofactor binding
PPS_RS06965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPS_RS06965	COG2146	nitrite reductase [NAD(P)H] activity
PPS_RS06970	COG2146	nitrite reductase [NAD(P)H] activity
PPS_RS06970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPS_RS06975	COG0583	DNA-binding transcription factor activity
PPS_RS06980	COG0545	Peptidyl-prolyl cis-trans isomerase
PPS_RS06985	COG3339	Conserved Protein
PPS_RS07000	COG3300	MHYT domain
PPS_RS07000	COG5001	Diguanylate cyclase
PPS_RS07030	COG0395	ABC-type sugar transport system, permease component
PPS_RS07050	COG0668	transmembrane transport
PPS_RS07055	COG1362	aminopeptidase activity
PPS_RS07060	COG0564	pseudouridine synthase activity
PPS_RS07065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PPS_RS07070	COG2894	cell division
PPS_RS07075	COG0850	regulation of cytokinetic process
PPS_RS07080	COG1560	Kdo2-lipid A biosynthetic process
PPS_RS07090	COG2853	Lipoprotein
PPS_RS07110	COG2113	Glycine betaine
PPS_RS07115	COG3162	membrane
PPS_RS07120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PPS_RS07135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PPS_RS07140	COG3089	Belongs to the UPF0270 family
PPS_RS07145	COG1363	Peptidase, m42
PPS_RS07150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PPS_RS07150	COG0189	ligase activity
PPS_RS07155	COG0367	asparagine synthase
PPS_RS07160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PPS_RS07160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS07165	COG2326	polyphosphate kinase activity
PPS_RS07170	COG0697	spore germination
PPS_RS07175	COG0114	fumarate hydratase activity
PPS_RS07185	COG0271	Belongs to the BolA IbaG family
PPS_RS07190	COG1054	Belongs to the UPF0176 family
PPS_RS07205	COG5002	protein histidine kinase activity
PPS_RS07205	COG5001	Diguanylate cyclase
PPS_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS07220	COG0546	phosphoglycolate phosphatase activity
PPS_RS07225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPS_RS07230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PPS_RS07240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PPS_RS07250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PPS_RS07255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PPS_RS07265	COG0776	regulation of translation
PPS_RS07275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PPS_RS07285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPS_RS07300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPS_RS07340	COG3436	PFAM IS66 Orf2 family protein
PPS_RS07360	COG1083	cytidylyl-transferase
PPS_RS07365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPS_RS07370	COG1216	Glycosyl transferase, family 2
PPS_RS07370	COG0438	transferase activity, transferring glycosyl groups
PPS_RS07395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS07405	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PPS_RS07415	COG0438	transferase activity, transferring glycosyl groups
PPS_RS07430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPS_RS07440	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PPS_RS07440	COG0517	IMP dehydrogenase activity
PPS_RS07445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PPS_RS07460	COG1215	transferase activity, transferring glycosyl groups
PPS_RS07475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PPS_RS07480	COG1555	photosystem II stabilization
PPS_RS07490	COG0284	orotidine-5'-phosphate decarboxylase activity
PPS_RS07495	COG2130	NADP-dependent
PPS_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS07505	COG0840	transmembrane signaling receptor activity
PPS_RS07510	COG3135	benzoate transporter
PPS_RS07515	COG0625	glutathione transferase activity
PPS_RS07525	COG0302	gtp cyclohydrolase
PPS_RS07530	COG2840	Smr protein MutS2
PPS_RS07560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PPS_RS07565	COG2814	Major facilitator Superfamily
PPS_RS07570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PPS_RS07600	COG1368	sulfuric ester hydrolase activity
PPS_RS07620	COG0519	Catalyzes the synthesis of GMP from XMP
PPS_RS07625	COG0598	Magnesium transport protein CorA
PPS_RS07630	COG0204	Acyl-transferase
PPS_RS07655	COG2814	Major facilitator Superfamily
PPS_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS07665	COG0583	DNA-binding transcription factor activity
PPS_RS07685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PPS_RS07690	COG1764	response to oxidative stress
PPS_RS07695	COG1846	Transcriptional regulator
PPS_RS07700	COG0583	DNA-binding transcription factor activity
PPS_RS07710	COG0583	DNA-binding transcription factor activity
PPS_RS07720	COG3214	Protein conserved in bacteria
PPS_RS07725	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PPS_RS07740	COG3384	dioxygenase
PPS_RS07745	COG0500	methyltransferase
PPS_RS07750	COG0501	Belongs to the peptidase M48B family
PPS_RS07755	COG0436	Aminotransferase
PPS_RS07760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPS_RS07765	COG0386	Belongs to the glutathione peroxidase family
PPS_RS07770	COG3437	response regulator, receiver
PPS_RS07770	COG3850	Histidine kinase
PPS_RS07770	COG2205	protein histidine kinase activity
PPS_RS07770	COG4999	Histidine kinase
PPS_RS07780	COG1956	GAF domain-containing protein
PPS_RS07845	COG3121	Chaperone
PPS_RS07860	COG1960	acyl-CoA dehydrogenase activity
PPS_RS07865	COG0625	glutathione transferase activity
PPS_RS07870	COG1131	(ABC) transporter
PPS_RS07875	COG0842	Transport permease protein
PPS_RS07885	COG2333	competence protein COMEC
PPS_RS07885	COG0658	competence protein
PPS_RS07890	COG0811	peptide transport
PPS_RS07895	COG0848	biopolymer transport protein
PPS_RS07900	COG1663	tetraacyldisaccharide 4'-kinase activity
PPS_RS07905	COG2835	tetraacyldisaccharide 4'-kinase activity
PPS_RS07910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PPS_RS07915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPS_RS07920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PPS_RS07925	COG1530	ribonuclease E activity
PPS_RS07935	COG0546	phosphoglycolate phosphatase activity
PPS_RS07940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPS_RS07940	COG0616	signal peptide processing
PPS_RS07945	COG0424	maF-like protein
PPS_RS07955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PPS_RS07960	COG0416	fatty acid biosynthetic process
PPS_RS07965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPS_RS07975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPS_RS07980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPS_RS07990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PPS_RS07995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PPS_RS08005	COG0084	hydrolase, TatD family'
PPS_RS08015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPS_RS08050	COG0556	nucleotide-excision repair
PPS_RS08065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPS_RS08115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPS_RS08120	COG3328	transposase activity
PPS_RS08140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PPS_RS08145	COG0066	3-isopropylmalate dehydratase activity
PPS_RS08150	COG2226	methyltransferase
PPS_RS08155	COG0473	3-isopropylmalate dehydrogenase activity
PPS_RS08180	COG0135	phosphoribosylanthranilate isomerase activity
PPS_RS08185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PPS_RS08190	COG0285	dihydrofolate synthase activity
PPS_RS08200	COG1286	toxin biosynthetic process
PPS_RS08245	COG0697	spore germination
PPS_RS08250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS08265	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPS_RS08265	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS08275	COG3038	cytochrome b561
PPS_RS08285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PPS_RS08290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPS_RS08295	COG0705	Rhomboid family
PPS_RS08300	COG3139	Protein of unknown function (DUF1315)
PPS_RS08310	COG0308	aminopeptidase N
PPS_RS08330	COG2706	6-phosphogluconolactonase activity
PPS_RS08350	COG0420	3'-5' exonuclease activity
PPS_RS08420	COG0714	Associated with various cellular activities
PPS_RS08435	COG3135	benzoate transporter
PPS_RS08445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPS_RS08480	COG2814	Major facilitator Superfamily
PPS_RS08490	COG0789	Transcriptional regulator
PPS_RS08495	COG2188	Transcriptional regulator
PPS_RS08510	COG0019	diaminopimelate decarboxylase activity
PPS_RS08515	COG0583	DNA-binding transcription factor activity
PPS_RS08530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PPS_RS08545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PPS_RS08560	COG0668	transmembrane transport
PPS_RS08585	COG2223	nitrite transmembrane transporter activity
PPS_RS08590	COG3707	response regulator
PPS_RS08595	COG1116	anion transmembrane transporter activity
PPS_RS08595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPS_RS08600	COG0167	dihydroorotate dehydrogenase activity
PPS_RS08605	COG0116	Belongs to the methyltransferase superfamily
PPS_RS08605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PPS_RS08615	COG2027	D-alanyl-D-alanine carboxypeptidase
PPS_RS08620	COG3171	Protein conserved in bacteria
PPS_RS08625	COG2205	protein histidine kinase activity
PPS_RS08625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS08630	COG2197	response regulator
PPS_RS08655	COG0004	ammonium transporteR
PPS_RS08680	COG0840	transmembrane signaling receptor activity
PPS_RS08695	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PPS_RS08705	COG0425	Belongs to the sulfur carrier protein TusA family
PPS_RS08710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPS_RS08715	COG1132	(ABC) transporter
PPS_RS08740	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPS_RS08755	COG1597	lipid kinase activity
PPS_RS08760	COG2197	response regulator
PPS_RS08765	COG3851	Histidine kinase
PPS_RS08780	COG0835	chemotaxis
PPS_RS08780	COG0784	Response regulator, receiver
PPS_RS08790	COG0741	lytic transglycosylase activity
PPS_RS08795	COG0488	(ABC) transporter
PPS_RS08800	COG0589	response to stress
PPS_RS08815	COG0183	Belongs to the thiolase family
PPS_RS08845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPS_RS08855	COG1376	ErfK ybiS ycfS ynhG family protein
PPS_RS08875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPS_RS08895	COG1477	protein flavinylation
PPS_RS08900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPS_RS08905	COG0584	glycerophosphoryl diester phosphodiesterase
PPS_RS08915	COG4591	ABC-type transport system involved in lipoprotein release permease component
PPS_RS08920	COG1136	(ABC) transporter
PPS_RS08925	COG4591	ABC-type transport system involved in lipoprotein release permease component
PPS_RS08940	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PPS_RS08940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PPS_RS08955	COG2853	Lipoprotein
PPS_RS08965	COG4566	intracellular signal transduction
PPS_RS08980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PPS_RS08985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPS_RS09030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPS_RS09200	COG3179	chitinase
PPS_RS09280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPS_RS09285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PPS_RS09290	COG2814	Major facilitator Superfamily
PPS_RS09310	COG1414	Transcriptional regulator
PPS_RS09325	COG3383	formate dehydrogenase (NAD+) activity
PPS_RS09335	COG0589	response to stress
PPS_RS09360	COG1595	DNA-templated transcription, initiation
PPS_RS09380	COG0010	Belongs to the arginase family
PPS_RS09390	COG2133	pyrroloquinoline quinone binding
PPS_RS09395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PPS_RS09405	COG0596	Alpha beta hydrolase
PPS_RS09410	COG1238	metal cluster binding
PPS_RS09430	COG0826	peptidase U32
PPS_RS09440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPS_RS09445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PPS_RS09450	COG0583	DNA-binding transcription factor activity
PPS_RS09470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPS_RS09480	COG0183	Belongs to the thiolase family
PPS_RS09485	COG1960	acyl-CoA dehydrogenase activity
PPS_RS09490	COG1024	Enoyl-CoA hydratase
PPS_RS09520	COG1320	monovalent cation:proton antiporter activity
PPS_RS09525	COG2212	antiporter activity
PPS_RS09535	COG0651	ATP synthesis coupled electron transport
PPS_RS09540	COG1006	Multisubunit Na H antiporter MnhC subunit
PPS_RS09545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PPS_RS09545	COG2111	Na H antiporter
PPS_RS09560	COG1335	isochorismatase
PPS_RS09615	COG4178	(ABC) transporter
PPS_RS09635	COG0730	response to heat
PPS_RS09650	COG0251	oxidation-reduction process
PPS_RS09655	COG3949	Membrane
PPS_RS09660	COG0840	transmembrane signaling receptor activity
PPS_RS09665	COG0583	DNA-binding transcription factor activity
PPS_RS09685	COG2186	Transcriptional regulator
PPS_RS09700	COG0840	transmembrane signaling receptor activity
PPS_RS09715	COG3328	transposase activity
PPS_RS09720	COG3284	Transcriptional regulator
PPS_RS09725	COG3842	ATPase activity
PPS_RS09730	COG3842	ATPase activity
PPS_RS09740	COG0395	ABC-type sugar transport system, permease component
PPS_RS09755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPS_RS09785	COG0544	peptidyl-prolyl cis-trans isomerase activity
PPS_RS09790	COG0740	serine-type endopeptidase activity
PPS_RS09795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PPS_RS09800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PPS_RS09810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPS_RS09850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PPS_RS09855	COG2259	Doxx family
PPS_RS09865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPS_RS09870	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PPS_RS09875	COG4181	ATPase activity
PPS_RS09890	COG1388	LysM domain
PPS_RS09890	COG1376	ErfK ybiS ycfS ynhG family protein
PPS_RS09905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PPS_RS09910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PPS_RS09915	COG0589	response to stress
PPS_RS09945	COG4067	protein conserved in archaea
PPS_RS09945	COG0189	ligase activity
PPS_RS09950	COG1802	Transcriptional regulator
PPS_RS09960	COG0372	Belongs to the citrate synthase family
PPS_RS09975	COG2079	MmgE PrpD family protein
PPS_RS09990	COG0720	synthase
PPS_RS10020	COG0517	IMP dehydrogenase activity
PPS_RS10035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PPS_RS10065	COG4251	negative regulation of phosphorylation
PPS_RS10105	COG2866	Carboxypeptidase
PPS_RS10110	COG2207	Transcriptional regulator
PPS_RS10115	COG2223	nitrite transmembrane transporter activity
PPS_RS10125	COG2853	Lipoprotein
PPS_RS10135	COG2205	protein histidine kinase activity
PPS_RS10160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPS_RS10185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PPS_RS10190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PPS_RS10190	COG0316	Belongs to the HesB IscA family
PPS_RS10195	COG1999	signal sequence binding
PPS_RS10210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PPS_RS10225	COG1982	Orn Lys Arg decarboxylase major
PPS_RS10230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPS_RS10270	COG0583	DNA-binding transcription factor activity
PPS_RS10275	COG0417	DNA replication proofreading
PPS_RS10295	COG3220	belongs to the UPF0276 family
PPS_RS10305	COG2259	Doxx family
PPS_RS10335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPS_RS10340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PPS_RS10375	COG1192	Involved in chromosome partitioning
PPS_RS10395	COG1120	ATPase activity
PPS_RS10400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPS_RS10415	COG4774	siderophore transport
PPS_RS10420	COG0583	DNA-binding transcription factor activity
PPS_RS10430	COG1253	flavin adenine dinucleotide binding
PPS_RS10440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS10460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPS_RS10470	COG0252	asparaginase activity
PPS_RS10475	COG1879	ABC-type sugar transport system periplasmic component
PPS_RS10480	COG1129	ABC transporter
PPS_RS10485	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPS_RS10490	COG1609	Transcriptional regulator
PPS_RS10495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPS_RS10500	COG1869	D-ribose catabolic process
PPS_RS10520	COG1278	Cold shock
PPS_RS10530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPS_RS10535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PPS_RS10540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PPS_RS10545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PPS_RS10550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PPS_RS10555	COG0072	phenylalanine-tRNA ligase activity
PPS_RS10560	COG0776	regulation of translation
PPS_RS10590	COG2066	Belongs to the glutaminase family
PPS_RS10595	COG2186	Transcriptional regulator
PPS_RS10615	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS10655	COG2873	o-acetylhomoserine
PPS_RS10670	COG4977	sequence-specific DNA binding
PPS_RS10690	COG0583	DNA-binding transcription factor activity
PPS_RS10695	COG2814	Major facilitator Superfamily
PPS_RS10700	COG0625	glutathione transferase activity
PPS_RS10720	COG2271	Major facilitator Superfamily
PPS_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS10745	COG1063	alcohol dehydrogenase
PPS_RS10750	COG2814	Major facilitator Superfamily
PPS_RS10755	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS10765	COG2026	Addiction module toxin, RelE StbE family
PPS_RS10775	COG0583	DNA-binding transcription factor activity
PPS_RS10800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS10810	COG4106	trans-aconitate 2-methyltransferase activity
PPS_RS10820	COG0583	DNA-binding transcription factor activity
PPS_RS10830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS10835	COG0217	transcriptional regulatory protein
PPS_RS10840	COG0583	DNA-binding transcription factor activity
PPS_RS10845	COG0076	glutamate decarboxylase activity
PPS_RS10850	COG0477	Major facilitator Superfamily
PPS_RS10855	COG1082	Xylose isomerase domain protein TIM barrel
PPS_RS10855	COG3185	4-Hydroxyphenylpyruvate dioxygenase
PPS_RS10870	COG3300	MHYT domain
PPS_RS10870	COG5001	Diguanylate cyclase
PPS_RS10895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PPS_RS10905	COG1301	dicarboxylic acid transport
PPS_RS10910	COG0583	DNA-binding transcription factor activity
PPS_RS10925	COG0210	DNA helicase
PPS_RS10935	COG0596	Alpha beta hydrolase
PPS_RS10945	COG0596	Alpha beta hydrolase
PPS_RS10950	COG0477	Major facilitator Superfamily
PPS_RS10975	COG0300	oxidoreductase activity
PPS_RS10995	COG0346	lactoylglutathione lyase activity
PPS_RS11020	COG2995	paraquat-inducible protein a
PPS_RS11025	COG3008	intermembrane lipid transfer
PPS_RS11035	COG2194	sulfuric ester hydrolase activity
PPS_RS11055	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS11060	COG0531	amino acid
PPS_RS11065	COG2197	response regulator
PPS_RS11075	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS11085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPS_RS11090	COG1053	succinate dehydrogenase
PPS_RS11100	COG0673	inositol 2-dehydrogenase activity
PPS_RS11115	COG1053	succinate dehydrogenase
PPS_RS11125	COG1053	succinate dehydrogenase
PPS_RS11130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPS_RS11135	COG1414	Transcriptional regulator
PPS_RS11160	COG1177	transmembrane transport
PPS_RS11165	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPS_RS11170	COG3842	ATPase activity
PPS_RS11175	COG1414	Transcriptional regulator
PPS_RS11180	COG1132	(ABC) transporter
PPS_RS11190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PPS_RS11200	COG1984	allophanate hydrolase subunit 2
PPS_RS11240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPS_RS11245	COG3217	Mosc domain protein beta barrel domain protein
PPS_RS11245	COG0633	Ferredoxin
PPS_RS11275	COG3158	transport of potassium into the cell
PPS_RS11305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPS_RS11315	COG0581	inorganic phosphate transmembrane transporter activity
PPS_RS11320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPS_RS11340	COG0174	glutamine synthetase
PPS_RS11345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PPS_RS11370	COG3046	protein related to deoxyribodipyrimidine photolyase
PPS_RS11380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PPS_RS11395	COG4221	oxidoreductase activity
PPS_RS11405	COG1366	Belongs to the anti-sigma-factor antagonist family
PPS_RS11405	COG2202	Pas domain
PPS_RS11410	COG0789	Transcriptional regulator
PPS_RS11425	COG2205	protein histidine kinase activity
PPS_RS11425	COG0784	Response regulator, receiver
PPS_RS11445	COG1131	(ABC) transporter
PPS_RS11460	COG4585	Histidine kinase
PPS_RS11520	COG4191	Histidine kinase
PPS_RS11525	COG0659	secondary active sulfate transmembrane transporter activity
PPS_RS11530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS11540	COG1538	Outer membrane efflux protein
PPS_RS11545	COG0477	Major facilitator Superfamily
PPS_RS11550	COG3958	Transketolase
PPS_RS11555	COG3959	Transketolase, thiamine diphosphate binding domain
PPS_RS11560	COG0371	Dehydrogenase
PPS_RS11565	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS11570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPS_RS11580	COG1454	alcohol dehydrogenase
PPS_RS11590	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS11600	COG1129	ABC transporter
PPS_RS11605	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPS_RS11610	COG1802	Transcriptional regulator
PPS_RS11615	COG2116	formate transmembrane transporter activity
PPS_RS11645	COG0668	transmembrane transport
PPS_RS11660	COG2323	membrane
PPS_RS11670	COG1058	Belongs to the CinA family
PPS_RS11670	COG1546	Belongs to the CinA family
PPS_RS11680	COG1063	alcohol dehydrogenase
PPS_RS11740	COG0583	DNA-binding transcription factor activity
PPS_RS11745	COG0583	DNA-binding transcription factor activity
PPS_RS11750	COG0604	alcohol dehydrogenase
PPS_RS11750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPS_RS11750	COG3321	synthase
PPS_RS11750	COG4221	oxidoreductase activity
PPS_RS11760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PPS_RS11765	COG0431	NADPH-dependent FMN reductase
PPS_RS11770	COG0798	PFAM Bile acid sodium symporter
PPS_RS11775	COG0640	Transcriptional regulator
PPS_RS11795	COG0583	DNA-binding transcription factor activity
PPS_RS11800	COG2828	Protein conserved in bacteria
PPS_RS11805	COG1301	dicarboxylic acid transport
PPS_RS11810	COG2851	Citrate transporter
PPS_RS11825	COG2203	Gaf domain
PPS_RS11825	COG5001	Diguanylate cyclase
PPS_RS11825	COG4251	negative regulation of phosphorylation
PPS_RS11825	COG3706	GGDEF domain
PPS_RS11830	COG1090	epimerase
PPS_RS11860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPS_RS11885	COG2113	Glycine betaine
PPS_RS11890	COG0006	proline dipeptidase activity
PPS_RS11895	COG1063	alcohol dehydrogenase
PPS_RS11910	COG4638	Rieske (2fe-2S)
PPS_RS11915	COG0583	DNA-binding transcription factor activity
PPS_RS11920	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS11930	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS11935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPS_RS11940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS11945	COG2207	Transcriptional regulator
PPS_RS11945	COG0662	Cupin 2, conserved barrel domain protein
PPS_RS11950	COG0251	oxidation-reduction process
PPS_RS11960	COG2271	Major facilitator Superfamily
PPS_RS11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS11975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPS_RS11985	COG0583	DNA-binding transcription factor activity
PPS_RS11990	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS11995	COG2271	Major facilitator Superfamily
PPS_RS12000	COG1802	Transcriptional regulator
PPS_RS12005	COG4977	sequence-specific DNA binding
PPS_RS12010	COG4638	Rieske (2fe-2S)
PPS_RS12015	COG2113	Glycine betaine
PPS_RS12020	COG4176	ABC-type proline glycine betaine transport system permease component
PPS_RS12135	COG2207	Transcriptional regulator
PPS_RS12150	COG3268	Saccharopine dehydrogenase
PPS_RS12210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PPS_RS12255	COG1192	Involved in chromosome partitioning
PPS_RS12290	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPS_RS12305	COG0523	cobalamin synthesis protein
PPS_RS12310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPS_RS12320	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS12350	COG0840	transmembrane signaling receptor activity
PPS_RS12360	COG0372	Belongs to the citrate synthase family
PPS_RS12390	COG1024	Enoyl-CoA hydratase
PPS_RS12395	COG0604	alcohol dehydrogenase
PPS_RS12400	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PPS_RS12405	COG1960	acyl-CoA dehydrogenase activity
PPS_RS12420	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPS_RS12425	COG1177	transmembrane transport
PPS_RS12455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PPS_RS12465	COG0251	oxidation-reduction process
PPS_RS12475	COG0477	Major facilitator Superfamily
PPS_RS12490	COG0235	Class ii aldolase
PPS_RS12495	COG0477	Major facilitator Superfamily
PPS_RS12500	COG0583	DNA-binding transcription factor activity
PPS_RS12510	COG1113	amino acid transport
PPS_RS12520	COG2423	ornithine cyclodeaminase activity
PPS_RS12530	COG3039	Transposase
PPS_RS12535	COG0697	spore germination
PPS_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS12555	COG0604	alcohol dehydrogenase
PPS_RS12555	COG3321	synthase
PPS_RS12565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS12575	COG4948	Mandelate Racemase Muconate Lactonizing
PPS_RS12585	COG0582	viral genome integration into host DNA
PPS_RS12590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPS_RS12740	COG0305	Participates in initiation and elongation during chromosome replication
PPS_RS12970	COG0583	DNA-binding transcription factor activity
PPS_RS12975	COG2721	sulfolactate sulfo-lyase activity
PPS_RS12990	COG2271	Major facilitator Superfamily
PPS_RS13000	COG1199	ATP-dependent helicase activity
PPS_RS13000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPS_RS13010	COG4974	Belongs to the 'phage' integrase family
PPS_RS13015	COG0829	nickel cation binding
PPS_RS13020	COG0831	urea catabolic process
PPS_RS13025	COG0832	Belongs to the urease beta subunit family
PPS_RS13030	COG0804	urea catabolic process
PPS_RS13035	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PPS_RS13045	COG0830	nickel cation binding
PPS_RS13050	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PPS_RS13105	COG0840	transmembrane signaling receptor activity
PPS_RS13110	COG1968	undecaprenyl-diphosphatase activity
PPS_RS13130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PPS_RS13135	COG1252	NADH dehydrogenase
PPS_RS13145	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS13145	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPS_RS13155	COG0235	Class ii aldolase
PPS_RS13165	COG0393	Putative heavy-metal-binding
PPS_RS13205	COG4221	oxidoreductase activity
PPS_RS13215	COG1396	sequence-specific DNA binding
PPS_RS13215	COG1917	Cupin 2, conserved barrel domain protein
PPS_RS13225	COG3038	cytochrome b561
PPS_RS13235	COG1595	DNA-templated transcription, initiation
PPS_RS13290	COG3064	Membrane
PPS_RS13310	COG0583	DNA-binding transcription factor activity
PPS_RS13320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPS_RS13360	COG2204	response regulator
PPS_RS13365	COG0625	glutathione transferase activity
PPS_RS13380	COG0488	(ABC) transporter
PPS_RS13385	COG2135	peptidase activity
PPS_RS13395	COG1858	cytochrome C peroxidase
PPS_RS13425	COG1301	dicarboxylic acid transport
PPS_RS13455	COG2175	clavaminate synthase activity
PPS_RS13460	COG3246	L-lysine catabolic process to acetate
PPS_RS13465	COG2814	Major facilitator Superfamily
PPS_RS13480	COG2855	membrane
PPS_RS13515	COG1960	acyl-CoA dehydrogenase activity
PPS_RS13520	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS13525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPS_RS13545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPS_RS13570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPS_RS13575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPS_RS13580	COG4574	serine-type endopeptidase inhibitor activity
PPS_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS13590	COG2610	gluconate transmembrane transporter activity
PPS_RS13595	COG3290	protein histidine kinase activity
PPS_RS13595	COG3829	transcription factor binding
PPS_RS13600	COG4239	(ABC) transporter, permease
PPS_RS13605	COG4174	ABC transporter (Permease)
PPS_RS13610	COG4166	transmembrane transport
PPS_RS13615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPS_RS13620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PPS_RS13625	COG1881	PFAM PEBP family protein
PPS_RS13635	COG2356	endonuclease I
PPS_RS13640	COG2814	Major facilitator Superfamily
PPS_RS13655	COG0531	amino acid
PPS_RS13665	COG2197	response regulator
PPS_RS13670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PPS_RS13690	COG0678	peroxiredoxin activity
PPS_RS13700	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS13705	COG0583	DNA-binding transcription factor activity
PPS_RS13720	COG0028	Belongs to the TPP enzyme family
PPS_RS13770	COG0583	DNA-binding transcription factor activity
PPS_RS13780	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PPS_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS13790	COG4977	sequence-specific DNA binding
PPS_RS13820	COG1522	sequence-specific DNA binding
PPS_RS13855	COG3327	negative regulation of DNA-templated transcription, initiation
PPS_RS13865	COG1024	Enoyl-CoA hydratase
PPS_RS13870	COG1024	Enoyl-CoA hydratase
PPS_RS13875	COG1250	3-hydroxyacyl-CoA dehydrogenase
PPS_RS13880	COG2050	protein possibly involved in aromatic compounds catabolism
PPS_RS13885	COG0183	Belongs to the thiolase family
PPS_RS13895	COG3396	Phenylacetate-CoA oxygenase
PPS_RS13900	COG3460	Phenylacetate-CoA oxygenase
PPS_RS13905	COG3396	Phenylacetate-CoA oxygenase
PPS_RS13910	COG2151	metal-sulfur cluster biosynthetic enzyme
PPS_RS13915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PPS_RS13920	COG3162	membrane
PPS_RS13935	COG2030	dehydratase
PPS_RS13935	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS13955	COG0494	nUDIX hydrolase
PPS_RS13975	COG3568	Endonuclease Exonuclease Phosphatase
PPS_RS13980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPS_RS13985	COG0392	lysyltransferase activity
PPS_RS14015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PPS_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS14040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPS_RS14045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PPS_RS14050	COG2890	protein-(glutamine-N5) methyltransferase activity
PPS_RS14075	COG0667	Aldo Keto reductase
PPS_RS14080	COG2837	iron assimilation
PPS_RS14115	COG5001	Diguanylate cyclase
PPS_RS14115	COG4251	negative regulation of phosphorylation
PPS_RS14115	COG3706	GGDEF domain
PPS_RS14115	COG2203	Gaf domain
PPS_RS14135	COG0402	S-adenosylhomocysteine deaminase activity
PPS_RS14140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PPS_RS14155	COG1999	signal sequence binding
PPS_RS14175	COG1929	Belongs to the glycerate kinase type-1 family
PPS_RS14180	COG3835	regulator
PPS_RS14185	COG2271	Major facilitator Superfamily
PPS_RS14190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPS_RS14195	COG0667	Aldo Keto reductase
PPS_RS14205	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS14210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPS_RS14235	COG3135	benzoate transporter
PPS_RS14240	COG3485	protocatechuate 3,4-dioxygenase
PPS_RS14245	COG2814	Major facilitator Superfamily
PPS_RS14315	COG0583	DNA-binding transcription factor activity
PPS_RS14320	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS14340	COG0174	glutamine synthetase
PPS_RS14350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS14360	COG1760	l-serine dehydratase
PPS_RS14365	COG0583	DNA-binding transcription factor activity
PPS_RS14370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPS_RS14385	COG0438	transferase activity, transferring glycosyl groups
PPS_RS14390	COG2990	Protein conserved in bacteria
PPS_RS14395	COG1215	transferase activity, transferring glycosyl groups
PPS_RS14400	COG1045	serine acetyltransferase
PPS_RS14435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PPS_RS14460	COG1396	sequence-specific DNA binding
PPS_RS14465	COG2031	fatty acid transporter
PPS_RS14475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PPS_RS14485	COG0656	L-ascorbic acid biosynthetic process
PPS_RS14490	COG0587	DNA-directed DNA polymerase activity
PPS_RS14505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPS_RS14510	COG1280	lysine exporter protein (LysE YggA)
PPS_RS14515	COG0583	DNA-binding transcription factor activity
PPS_RS14520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPS_RS14535	COG1414	Transcriptional regulator
PPS_RS14540	COG0154	amidase activity
PPS_RS14550	COG1473	amidohydrolase
PPS_RS14585	COG2369	cell adhesion
PPS_RS14720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPS_RS14730	COG1609	Transcriptional regulator
PPS_RS14850	COG3813	Protein conserved in bacteria
PPS_RS14855	COG2197	response regulator
PPS_RS14860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS14860	COG2205	protein histidine kinase activity
PPS_RS14945	COG1609	Transcriptional regulator
PPS_RS14950	COG3265	gluconokinase activity
PPS_RS14965	COG2204	response regulator
PPS_RS14970	COG2205	protein histidine kinase activity
PPS_RS14975	COG5002	protein histidine kinase activity
PPS_RS14980	COG0739	heme binding
PPS_RS14980	COG0741	lytic transglycosylase activity
PPS_RS14980	COG1196	nuclear chromosome segregation
PPS_RS14990	COG1459	type II secretion system
PPS_RS14995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS15020	COG4191	Histidine kinase
PPS_RS15020	COG0784	Response regulator, receiver
PPS_RS15040	COG2200	EAL domain
PPS_RS15050	COG1253	flavin adenine dinucleotide binding
PPS_RS15095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PPS_RS15105	COG1215	transferase activity, transferring glycosyl groups
PPS_RS15120	COG5001	Diguanylate cyclase
PPS_RS15125	COG2205	protein histidine kinase activity
PPS_RS15130	COG0745	RESPONSE REGULATOR receiver
PPS_RS15135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS15145	COG0746	molybdenum cofactor guanylyltransferase activity
PPS_RS15150	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS15175	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS15195	COG1132	(ABC) transporter
PPS_RS15200	COG3284	Transcriptional regulator
PPS_RS15235	COG2165	general secretion pathway protein
PPS_RS15240	COG2165	general secretion pathway protein
PPS_RS15270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPS_RS15275	COG2204	response regulator
PPS_RS15345	COG3052	prosthetic group binding
PPS_RS15365	COG1960	acyl-CoA dehydrogenase activity
PPS_RS15370	COG0583	DNA-binding transcription factor activity
PPS_RS15380	COG2384	SAM-dependent methyltransferase
PPS_RS15390	COG0826	peptidase U32
PPS_RS15410	COG0019	diaminopimelate decarboxylase activity
PPS_RS15425	COG0583	DNA-binding transcription factor activity
PPS_RS15440	COG0579	oxidoreductase
PPS_RS15460	COG0307	riboflavin synthase, alpha
PPS_RS15475	COG0113	porphobilinogen synthase activity
PPS_RS15485	COG1113	amino acid transport
PPS_RS15490	COG0579	oxidoreductase
PPS_RS15500	COG1802	Transcriptional regulator
PPS_RS15505	COG0745	RESPONSE REGULATOR receiver
PPS_RS15510	COG5002	protein histidine kinase activity
PPS_RS15510	COG3850	Histidine kinase
PPS_RS15515	COG0215	cysteine-tRNA ligase activity
PPS_RS15520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPS_RS15530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PPS_RS15535	COG2366	antibiotic biosynthetic process
PPS_RS15575	COG0729	surface antigen
PPS_RS15585	COG0708	Exodeoxyribonuclease III
PPS_RS15590	COG1309	transcriptional regulator
PPS_RS15595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPS_RS15605	COG3257	ureidoglycine aminohydrolase activity
PPS_RS15615	COG0583	DNA-binding transcription factor activity
PPS_RS15620	COG0405	Gamma-glutamyltransferase
PPS_RS15635	COG2207	Transcriptional regulator
PPS_RS15640	COG0789	Transcriptional regulator
PPS_RS15650	COG1285	pathogenesis
PPS_RS15660	COG0348	domain, Protein
PPS_RS15665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS15675	COG0784	Response regulator, receiver
PPS_RS15675	COG4191	Histidine kinase
PPS_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS15685	COG1477	protein flavinylation
PPS_RS15700	COG2814	Major facilitator Superfamily
PPS_RS15705	COG1566	PFAM secretion protein HlyD family protein
PPS_RS15710	COG1846	Transcriptional regulator
PPS_RS15720	COG4566	intracellular signal transduction
PPS_RS15725	COG4191	Histidine kinase
PPS_RS15730	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS15735	COG1960	acyl-CoA dehydrogenase activity
PPS_RS15745	COG2056	Na+-H+ antiporter family
PPS_RS15750	COG0840	transmembrane signaling receptor activity
PPS_RS15760	COG4176	ABC-type proline glycine betaine transport system permease component
PPS_RS15790	COG1280	lysine exporter protein (LysE YggA)
PPS_RS15795	COG2814	Major facilitator Superfamily
PPS_RS15800	COG0583	DNA-binding transcription factor activity
PPS_RS15840	COG4774	siderophore transport
PPS_RS15845	COG3712	iron ion homeostasis
PPS_RS15850	COG1595	DNA-templated transcription, initiation
PPS_RS15905	COG0814	amino acid
PPS_RS15940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS15945	COG1126	abc transporter atp-binding protein
PPS_RS15950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PPS_RS15955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPS_RS15960	COG2271	Major facilitator Superfamily
PPS_RS15965	COG2721	sulfolactate sulfo-lyase activity
PPS_RS15970	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS15975	COG2186	Transcriptional regulator
PPS_RS16035	COG1944	ATP diphosphatase activity
PPS_RS16050	COG2010	Cytochrome c
PPS_RS16080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PPS_RS16090	COG4991	sh3 domain protein
PPS_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS16110	COG1942	4-Oxalocrotonate Tautomerase
PPS_RS16120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PPS_RS16130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPS_RS16135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPS_RS16140	COG1116	anion transmembrane transporter activity
PPS_RS16155	COG2207	Transcriptional regulator
PPS_RS16160	COG1959	2 iron, 2 sulfur cluster binding
PPS_RS16170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PPS_RS16175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PPS_RS16180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPS_RS16190	COG2267	carboxylic ester hydrolase activity
PPS_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS16205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPS_RS16210	COG2186	Transcriptional regulator
PPS_RS16220	COG4191	Histidine kinase
PPS_RS16220	COG0784	Response regulator, receiver
PPS_RS16225	COG1280	lysine exporter protein (LysE YggA)
PPS_RS16240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PPS_RS16245	COG0004	ammonium transporteR
PPS_RS16250	COG0069	glutamate synthase activity
PPS_RS16255	COG2218	PFAM glutamate synthase alpha subunit domain protein
PPS_RS16260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PPS_RS16290	COG3039	Transposase
PPS_RS16310	COG2855	membrane
PPS_RS16315	COG1611	Belongs to the LOG family
PPS_RS16320	COG3300	MHYT domain
PPS_RS16320	COG5001	Diguanylate cyclase
PPS_RS16340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPS_RS16345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PPS_RS16365	COG0656	L-ascorbic acid biosynthetic process
PPS_RS16370	COG5001	Diguanylate cyclase
PPS_RS16380	COG3485	protocatechuate 3,4-dioxygenase
PPS_RS16385	COG4829	muconolactone delta-isomerase
PPS_RS16390	COG4948	Mandelate Racemase Muconate Lactonizing
PPS_RS16400	COG3048	D-serine ammonia-lyase activity
PPS_RS16420	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPS_RS16435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PPS_RS16445	COG0045	succinate-CoA ligase (ADP-forming) activity
PPS_RS16450	COG1960	acyl-CoA dehydrogenase activity
PPS_RS16455	COG1024	Enoyl-CoA hydratase
PPS_RS16460	COG0833	amino acid
PPS_RS16485	COG1024	Enoyl-CoA hydratase
PPS_RS16495	COG0577	efflux transmembrane transporter activity
PPS_RS16510	COG3039	Transposase
PPS_RS16545	COG0768	penicillin binding
PPS_RS16575	COG2186	Transcriptional regulator
PPS_RS16580	COG0277	FAD linked oxidase domain protein
PPS_RS16585	COG0277	FAD linked oxidase domain protein
PPS_RS16590	COG0247	lactate metabolic process
PPS_RS16595	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PPS_RS16615	COG2807	transmembrane transport
PPS_RS16620	COG0590	tRNA wobble adenosine to inosine editing
PPS_RS16625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPS_RS16635	COG0183	Belongs to the thiolase family
PPS_RS16640	COG1250	3-hydroxyacyl-CoA dehydrogenase
PPS_RS16650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS16650	COG0784	Response regulator, receiver
PPS_RS16650	COG2205	protein histidine kinase activity
PPS_RS16650	COG2198	Histidine kinase
PPS_RS16655	COG5002	protein histidine kinase activity
PPS_RS16655	COG0784	Response regulator, receiver
PPS_RS16655	COG2205	protein histidine kinase activity
PPS_RS16665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPS_RS16670	COG0784	Response regulator, receiver
PPS_RS16670	COG5002	protein histidine kinase activity
PPS_RS16705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPS_RS16750	COG1686	Belongs to the peptidase S11 family
PPS_RS16790	COG1121	(ABC) transporter
PPS_RS16795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPS_RS16835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPS_RS16850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPS_RS16850	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPS_RS16860	COG0583	DNA-binding transcription factor activity
PPS_RS16870	COG1741	Belongs to the pirin family
PPS_RS16880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPS_RS16890	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPS_RS16895	COG1177	transmembrane transport
PPS_RS16900	COG3842	ATPase activity
PPS_RS16905	COG2885	chlorophyll binding
PPS_RS16910	COG0861	Integral membrane protein TerC family
PPS_RS16925	COG1104	cysteine desulfurase activity
PPS_RS16930	COG5654	RES domain protein
PPS_RS16935	COG5642	Protein of unknown function (DUF2384)
PPS_RS16945	COG0583	DNA-binding transcription factor activity
PPS_RS16960	COG2814	Major facilitator Superfamily
PPS_RS16970	COG1064	alcohol dehydrogenase
PPS_RS16975	COG2207	Transcriptional regulator
PPS_RS16995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPS_RS17005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PPS_RS17010	COG3132	Protein of unknown function, DUF480
PPS_RS17020	COG3634	alkyl hydroperoxide reductase activity
PPS_RS17040	COG3258	Cytochrome c
PPS_RS17045	COG2863	cytochrome
PPS_RS17075	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PPS_RS17085	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PPS_RS17090	COG0745	RESPONSE REGULATOR receiver
PPS_RS17095	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PPS_RS17100	COG0784	Response regulator, receiver
PPS_RS17100	COG4191	Histidine kinase
PPS_RS17115	COG2259	Doxx family
PPS_RS17125	COG1064	alcohol dehydrogenase
PPS_RS17140	COG0583	DNA-binding transcription factor activity
PPS_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS17150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPS_RS17200	COG0616	signal peptide processing
PPS_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS17225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPS_RS17250	COG0471	metal ion transport
PPS_RS17250	COG0490	domain, Protein
PPS_RS17255	COG2199	diguanylate cyclase activity
PPS_RS17270	COG1335	isochorismatase
PPS_RS17345	COG2433	Pfam Transposase IS66
PPS_RS17370	COG3039	Transposase
PPS_RS17385	COG0583	DNA-binding transcription factor activity
PPS_RS17395	COG0154	amidase activity
PPS_RS17400	COG0523	cobalamin synthesis protein
PPS_RS17405	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PPS_RS17410	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS17435	COG0583	DNA-binding transcription factor activity
PPS_RS17440	COG3960	tartronate-semialdehyde synthase activity
PPS_RS17445	COG3622	Belongs to the hyi family
PPS_RS17450	COG2084	Dehydrogenase
PPS_RS17455	COG2186	Transcriptional regulator
PPS_RS17460	COG0277	FAD linked oxidase domain protein
PPS_RS17465	COG0277	FAD linked oxidase domain protein
PPS_RS17485	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PPS_RS17490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PPS_RS17500	COG0697	spore germination
PPS_RS17505	COG2801	Transposase and inactivated derivatives
PPS_RS17510	COG2963	transposase activity
PPS_RS17515	COG2814	Major facilitator Superfamily
PPS_RS17520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PPS_RS17530	COG0583	DNA-binding transcription factor activity
PPS_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS17570	COG0154	amidase activity
PPS_RS17650	COG4974	Belongs to the 'phage' integrase family
PPS_RS17665	COG2233	PERMEase
PPS_RS17685	COG2920	part of a sulfur-relay system
PPS_RS17690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPS_RS17695	COG0435	Glutathione S-transferase
PPS_RS17700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PPS_RS17700	COG1648	precorrin-2 dehydrogenase activity
PPS_RS17705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PPS_RS17710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPS_RS17715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPS_RS17720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PPS_RS17725	COG1674	ftsk spoiiie
PPS_RS17730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PPS_RS17735	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PPS_RS17740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PPS_RS17745	COG0542	response to heat
PPS_RS17750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PPS_RS17755	COG1278	Cold shock
PPS_RS17775	COG0482	sulfurtransferase activity
PPS_RS17780	COG2915	High frequency lysogenization protein hflD homolog
PPS_RS17790	COG2850	peptidyl-arginine hydroxylation
PPS_RS17795	COG2153	protein acetylation
PPS_RS17800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PPS_RS17805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS17820	COG2816	NAD+ diphosphatase activity
PPS_RS17825	COG1024	Enoyl-CoA hydratase
PPS_RS17830	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPS_RS17840	COG3040	lipid binding
PPS_RS17845	COG1234	tRNA 3'-trailer cleavage
PPS_RS17855	COG1953	Uracil, thiamine, allantoin
PPS_RS17865	COG0493	'glutamate synthase
PPS_RS17875	COG1309	transcriptional regulator
PPS_RS17885	COG3387	PFAM Glycoside hydrolase 15-related
PPS_RS17890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPS_RS17895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PPS_RS17920	COG0297	glycogen (starch) synthase activity
PPS_RS17925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PPS_RS17930	COG1640	4-alpha-glucanotransferase
PPS_RS17950	COG3568	Endonuclease Exonuclease Phosphatase
PPS_RS17960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PPS_RS17965	COG0366	Alpha amylase catalytic
PPS_RS17975	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS17980	COG1960	acyl-CoA dehydrogenase activity
PPS_RS17985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PPS_RS18005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPS_RS18025	COG0583	DNA-binding transcription factor activity
PPS_RS18030	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS18035	COG2271	Major facilitator Superfamily
PPS_RS18040	COG3959	Transketolase, thiamine diphosphate binding domain
PPS_RS18045	COG3958	Transketolase
PPS_RS18050	COG1126	abc transporter atp-binding protein
PPS_RS18055	COG0765	amino acid transport
PPS_RS18060	COG0765	amino acid transport
PPS_RS18065	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PPS_RS18085	COG0840	transmembrane signaling receptor activity
PPS_RS18140	COG0322	excinuclease ABC activity
PPS_RS18165	COG0306	phosphate transporter
PPS_RS18170	COG0625	glutathione transferase activity
PPS_RS18175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PPS_RS18175	COG2050	protein possibly involved in aromatic compounds catabolism
PPS_RS18180	COG1113	amino acid transport
PPS_RS18185	COG0583	DNA-binding transcription factor activity
PPS_RS18190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PPS_RS18205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PPS_RS18240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPS_RS18245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPS_RS18250	COG0649	NAD binding
PPS_RS18250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPS_RS18265	COG1034	ATP synthesis coupled electron transport
PPS_RS18270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PPS_RS18275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PPS_RS18285	COG0713	ATP synthesis coupled electron transport
PPS_RS18300	COG1007	ATP synthesis coupled electron transport
PPS_RS18335	COG0431	NADPH-dependent FMN reductase
PPS_RS18355	COG0328	RNA-DNA hybrid ribonuclease activity
PPS_RS18365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPS_RS18370	COG0741	lytic transglycosylase activity
PPS_RS18370	COG1388	LysM domain
PPS_RS18375	COG4166	transmembrane transport
PPS_RS18380	COG4166	transmembrane transport
PPS_RS18385	COG4174	ABC transporter (Permease)
PPS_RS18390	COG4239	(ABC) transporter, permease
PPS_RS18395	COG4172	Belongs to the ABC transporter superfamily
PPS_RS18415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PPS_RS18420	COG0583	DNA-binding transcription factor activity
PPS_RS18445	COG0745	RESPONSE REGULATOR receiver
PPS_RS18450	COG2205	protein histidine kinase activity
PPS_RS18455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PPS_RS18465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PPS_RS18475	COG0628	permease
PPS_RS18505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PPS_RS18520	COG3850	Histidine kinase
PPS_RS18520	COG2205	protein histidine kinase activity
PPS_RS18520	COG3437	response regulator, receiver
PPS_RS18520	COG4999	Histidine kinase
PPS_RS18525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPS_RS18540	COG1741	Belongs to the pirin family
PPS_RS18550	COG0326	Molecular chaperone. Has ATPase activity
PPS_RS18575	COG2801	Transposase and inactivated derivatives
PPS_RS18595	COG0045	succinate-CoA ligase (ADP-forming) activity
PPS_RS18600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPS_RS18620	COG1053	succinate dehydrogenase
PPS_RS18625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PPS_RS18630	COG2009	succinate dehydrogenase
PPS_RS18655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS18660	COG2885	chlorophyll binding
PPS_RS18660	COG3047	cAMP biosynthetic process
PPS_RS18705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS18710	COG1136	(ABC) transporter
PPS_RS18710	COG0577	efflux transmembrane transporter activity
PPS_RS18735	COG0657	acetylesterase activity
PPS_RS18750	COG0642	Histidine kinase
PPS_RS18810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPS_RS18830	COG1131	(ABC) transporter
PPS_RS18860	COG3123	guanosine phosphorylase activity
PPS_RS18870	COG3278	Belongs to the heme-copper respiratory oxidase family
PPS_RS18885	COG2010	Cytochrome c
PPS_RS18890	COG3278	Belongs to the heme-copper respiratory oxidase family
PPS_RS18905	COG2010	Cytochrome c
PPS_RS18910	COG0348	domain, Protein
PPS_RS18920	COG2217	Heavy metal translocating P-type atpase
PPS_RS18940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPS_RS18945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPS_RS18950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PPS_RS18955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PPS_RS18960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PPS_RS18980	COG0789	Transcriptional regulator
PPS_RS18990	COG2963	transposase activity
PPS_RS18995	COG2801	Transposase and inactivated derivatives
PPS_RS19015	COG3039	Transposase
PPS_RS19075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPS_RS19080	COG3115	cell septum assembly
PPS_RS19110	COG0402	S-adenosylhomocysteine deaminase activity
PPS_RS19115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PPS_RS19125	COG2252	PERMEase
PPS_RS19150	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PPS_RS19160	COG2233	PERMEase
PPS_RS19175	COG2354	Protein conserved in bacteria
PPS_RS19190	COG3960	tartronate-semialdehyde synthase activity
PPS_RS19195	COG3622	Belongs to the hyi family
PPS_RS19200	COG2084	Dehydrogenase
PPS_RS19210	COG0469	pyruvate kinase activity
PPS_RS19220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPS_RS19230	COG0116	Belongs to the methyltransferase superfamily
PPS_RS19230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PPS_RS19240	COG1522	sequence-specific DNA binding
PPS_RS19245	COG1953	Uracil, thiamine, allantoin
PPS_RS19280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPS_RS19305	COG1138	Cytochrome C-type biogenesis protein
PPS_RS19310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PPS_RS19330	COG4133	protoheme IX ABC transporter activity
PPS_RS19345	COG2257	FlhB HrpN YscU SpaS Family
PPS_RS19350	COG2207	Transcriptional regulator
PPS_RS19400	COG0835	chemotaxis
PPS_RS19410	COG1192	Involved in chromosome partitioning
PPS_RS19415	COG1360	Flagellar Motor Protein
PPS_RS19420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PPS_RS19425	COG2201	protein-glutamate methylesterase activity
PPS_RS19430	COG0643	Histidine kinase
PPS_RS19430	COG0784	Response regulator, receiver
PPS_RS19430	COG2198	Histidine kinase
PPS_RS19435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PPS_RS19460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPS_RS19475	COG1987	bacterial-type flagellum assembly
PPS_RS19515	COG0745	RESPONSE REGULATOR receiver
PPS_RS19525	COG2882	bacterial-type flagellum organization
PPS_RS19550	COG1677	Flagellar hook-basal body complex protein FliE
PPS_RS19585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PPS_RS19600	COG3039	Transposase
PPS_RS19605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPS_RS19625	COG1706	bacterial-type flagellum-dependent cell motility
PPS_RS19630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PPS_RS19640	COG4787	bacterial-type flagellum-dependent cell motility
PPS_RS19655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PPS_RS19665	COG1815	bacterial-type flagellum-dependent cell motility
PPS_RS19670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPS_RS19675	COG0784	Response regulator, receiver
PPS_RS19675	COG0835	chemotaxis
PPS_RS19695	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PPS_RS19700	COG2801	Transposase and inactivated derivatives
PPS_RS19710	COG0477	Major facilitator Superfamily
PPS_RS19720	COG1522	sequence-specific DNA binding
PPS_RS19725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PPS_RS19730	COG0022	dehydrogenase e1 component
PPS_RS19740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPS_RS19745	COG3706	GGDEF domain
PPS_RS19780	COG2239	Acts as a magnesium transporter
PPS_RS19805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PPS_RS19810	COG0527	aspartate kinase activity
PPS_RS19815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PPS_RS19825	COG2988	succinylglutamate desuccinylase activity
PPS_RS19835	COG3724	N-succinylarginine dihydrolase activity
PPS_RS19840	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS19855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PPS_RS19880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS19885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPS_RS19905	COG2154	pterin-4-alpha-carbinolamine dehydratase
PPS_RS19920	COG0247	lactate metabolic process
PPS_RS19920	COG0277	FAD linked oxidase domain protein
PPS_RS19930	COG1113	amino acid transport
PPS_RS19935	COG3344	reverse transcriptase
PPS_RS19945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PPS_RS19955	COG0009	L-threonylcarbamoyladenylate synthase
PPS_RS19960	COG0613	PHP domain protein
PPS_RS19965	COG2917	probably involved in intracellular septation
PPS_RS19970	COG2350	Protein conserved in bacteria
PPS_RS19975	COG0745	RESPONSE REGULATOR receiver
PPS_RS19990	COG0778	Nitroreductase
PPS_RS19995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PPS_RS20015	COG2207	Transcriptional regulator
PPS_RS20035	COG1752	Esterase of the alpha-beta hydrolase superfamily
PPS_RS20045	COG0514	ATP-dependent DNA helicase (RecQ)
PPS_RS20055	COG2832	Protein of unknown function (DUF454)
PPS_RS20070	COG0840	transmembrane signaling receptor activity
PPS_RS20085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PPS_RS20090	COG0583	DNA-binding transcription factor activity
PPS_RS20100	COG0697	spore germination
PPS_RS20120	COG0513	Belongs to the DEAD box helicase family
PPS_RS20125	COG0668	transmembrane transport
PPS_RS20130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PPS_RS20140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PPS_RS20165	COG1132	(ABC) transporter
PPS_RS20175	COG2188	Transcriptional regulator
PPS_RS20185	COG1643	Atp-dependent helicase
PPS_RS20190	COG0174	glutamine synthetase
PPS_RS20195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS20200	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS20205	COG0318	PFAM AMP-dependent synthetase and ligase
PPS_RS20210	COG2267	carboxylic ester hydrolase activity
PPS_RS20215	COG2030	dehydratase
PPS_RS20220	COG4941	Belongs to the sigma-70 factor family
PPS_RS20230	COG3795	YCII-related domain
PPS_RS20250	COG0242	peptide deformylase activity
PPS_RS20255	COG1295	ribonuclease BN
PPS_RS20280	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PPS_RS20350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPS_RS20370	COG1984	allophanate hydrolase subunit 2
PPS_RS20375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PPS_RS20380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PPS_RS20385	COG2814	Major facilitator Superfamily
PPS_RS20400	COG0121	glutamine amidotransferase
PPS_RS20440	COG2801	Transposase and inactivated derivatives
PPS_RS20450	COG2983	Belongs to the UPF0260 family
PPS_RS20460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPS_RS20465	COG3100	YcgL domain-containing protein
PPS_RS20475	COG2194	sulfuric ester hydrolase activity
PPS_RS20490	COG0626	cystathionine gamma-synthase activity
PPS_RS20495	COG1522	sequence-specific DNA binding
PPS_RS20500	COG0243	molybdopterin cofactor binding
PPS_RS20505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPS_RS20510	COG3781	membrane
PPS_RS20515	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPS_RS20530	COG0531	amino acid
PPS_RS20535	COG3938	Belongs to the proline racemase family
PPS_RS20540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPS_RS20550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS20555	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS20560	COG0640	Transcriptional regulator
PPS_RS20575	COG0579	oxidoreductase
PPS_RS20580	COG3938	Belongs to the proline racemase family
PPS_RS20590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PPS_RS20595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPS_RS20605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PPS_RS20610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPS_RS20615	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PPS_RS20620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPS_RS20630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PPS_RS20640	COG0425	Belongs to the sulfur carrier protein TusA family
PPS_RS20645	COG4783	chaperone-mediated protein folding
PPS_RS20650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PPS_RS20660	COG0531	amino acid
PPS_RS20665	COG0840	transmembrane signaling receptor activity
PPS_RS20680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PPS_RS20685	COG0602	queuosine metabolic process
PPS_RS20690	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PPS_RS20695	COG2885	chlorophyll binding
PPS_RS20700	COG0823	Involved in the tonB-independent uptake of proteins
PPS_RS20720	COG0824	Thioesterase
PPS_RS20725	COG2255	four-way junction helicase activity
PPS_RS20730	COG0632	four-way junction helicase activity
PPS_RS20735	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PPS_RS20740	COG0217	transcriptional regulatory protein
PPS_RS20745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPS_RS20760	COG0783	Belongs to the Dps family
PPS_RS20770	COG2900	Belongs to the SlyX family
PPS_RS20785	COG0442	prolyl-tRNA aminoacylation
PPS_RS20795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPS_RS20820	COG3158	transport of potassium into the cell
PPS_RS20825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPS_RS20850	COG0519	Catalyzes the synthesis of GMP from XMP
PPS_RS20860	COG4807	Protein conserved in bacteria
PPS_RS20870	COG1301	dicarboxylic acid transport
PPS_RS20900	COG2205	protein histidine kinase activity
PPS_RS20905	COG0745	RESPONSE REGULATOR receiver
PPS_RS20915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PPS_RS20915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPS_RS20920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPS_RS20975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPS_RS20990	COG3088	subunit of a heme lyase
PPS_RS21000	COG1138	Cytochrome C-type biogenesis protein
PPS_RS21005	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PPS_RS21020	COG0596	Alpha beta hydrolase
PPS_RS21025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PPS_RS21055	COG4372	Transposase
PPS_RS21065	COG3436	PFAM IS66 Orf2 family protein
PPS_RS21070	COG4372	Transposase
PPS_RS21085	COG0477	Major facilitator Superfamily
PPS_RS21125	COG0579	oxidoreductase
PPS_RS21190	COG0583	DNA-binding transcription factor activity
PPS_RS21200	COG0625	glutathione transferase activity
PPS_RS21205	COG3012	SEC-C Motif Domain Protein
PPS_RS21205	COG3318	Belongs to the UPF0149 family
PPS_RS21210	COG0252	asparaginase activity
PPS_RS21220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPS_RS21250	COG2116	formate transmembrane transporter activity
PPS_RS21260	COG3706	GGDEF domain
PPS_RS21265	COG5001	Diguanylate cyclase
PPS_RS21265	COG3300	MHYT domain
PPS_RS21275	COG0583	DNA-binding transcription factor activity
PPS_RS21280	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS21295	COG1289	transmembrane transporter activity
PPS_RS21315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPS_RS21370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PPS_RS21375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PPS_RS21390	COG0259	pyridoxamine-phosphate oxidase activity
PPS_RS21395	COG2885	chlorophyll binding
PPS_RS21410	COG1199	ATP-dependent helicase activity
PPS_RS21445	COG3012	SEC-C Motif Domain Protein
PPS_RS21455	COG0653	protein targeting
PPS_RS21460	COG2814	Major facilitator Superfamily
PPS_RS21465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS21470	COG2366	antibiotic biosynthetic process
PPS_RS21475	COG1793	dna ligase
PPS_RS21475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PPS_RS21480	COG1793	dna ligase
PPS_RS21490	COG1201	RNA secondary structure unwinding
PPS_RS21505	COG0717	Belongs to the dCTP deaminase family
PPS_RS21510	COG1278	Cold shock
PPS_RS21515	COG0489	protein tyrosine kinase activity
PPS_RS21520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPS_RS21520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPS_RS21535	COG4659	FMN binding
PPS_RS21545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PPS_RS21555	COG2197	response regulator
PPS_RS21565	COG0137	argininosuccinate synthase activity
PPS_RS21575	COG0418	dihydroorotase activity
PPS_RS21580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPS_RS21585	COG0450	alkyl hydroperoxide reductase
PPS_RS21605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PPS_RS21610	COG0243	molybdopterin cofactor binding
PPS_RS21615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PPS_RS21620	COG3842	ATPase activity
PPS_RS21625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PPS_RS21635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PPS_RS21655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS21660	COG0765	amino acid transport
PPS_RS21665	COG0765	amino acid transport
PPS_RS21670	COG1126	abc transporter atp-binding protein
PPS_RS21690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPS_RS21695	COG0583	DNA-binding transcription factor activity
PPS_RS21700	COG0494	nUDIX hydrolase
PPS_RS21705	COG1201	RNA secondary structure unwinding
PPS_RS21710	COG0069	glutamate synthase activity
PPS_RS21715	COG1113	amino acid transport
PPS_RS21725	COG1695	Transcriptional regulator
PPS_RS21730	COG2375	cellular response to nickel ion
PPS_RS21740	COG4628	conserved protein (DUF2132)
PPS_RS21745	COG4206	TonB-dependent receptor
PPS_RS21760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PPS_RS21770	COG2226	methyltransferase
PPS_RS21775	COG0500	methyltransferase
PPS_RS21790	COG0642	Histidine kinase
PPS_RS21795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PPS_RS21800	COG1381	Involved in DNA repair and RecF pathway recombination
PPS_RS21805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PPS_RS21810	COG0571	ribonuclease III activity
PPS_RS21815	COG0681	Belongs to the peptidase S26 family
PPS_RS21820	COG0481	GTPase activity
PPS_RS21830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPS_RS21860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PPS_RS21865	COG0354	folic acid binding
PPS_RS21905	COG3180	Ammonia monooxygenase
PPS_RS21910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PPS_RS21950	COG3328	transposase activity
PPS_RS21975	COG4191	Histidine kinase
PPS_RS21985	COG0477	Major facilitator Superfamily
PPS_RS22015	COG2207	Transcriptional regulator
PPS_RS22025	COG0583	DNA-binding transcription factor activity
PPS_RS22035	COG2910	NAD(P)H-binding
PPS_RS22050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PPS_RS22055	COG0477	Major facilitator Superfamily
PPS_RS22060	COG1309	transcriptional regulator
PPS_RS22065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS22090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPS_RS22095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPS_RS22100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PPS_RS22105	COG0477	Major facilitator Superfamily
PPS_RS22110	COG0183	Belongs to the thiolase family
PPS_RS22115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PPS_RS22120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PPS_RS22125	COG2814	Major facilitator Superfamily
PPS_RS22130	COG1414	Transcriptional regulator
PPS_RS22140	COG0306	phosphate transporter
PPS_RS22145	COG0433	COG0433 Predicted ATPase
PPS_RS22150	COG0840	transmembrane signaling receptor activity
PPS_RS22170	COG0788	formyltetrahydrofolate deformylase activity
PPS_RS22180	COG2925	Exonuclease
PPS_RS22195	COG0469	pyruvate kinase activity
PPS_RS22210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPS_RS22210	COG3153	acetyltransferase
PPS_RS22225	COG0693	protein deglycase activity
PPS_RS22230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPS_RS22275	COG1902	pentaerythritol trinitrate reductase activity
PPS_RS22285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPS_RS22290	COG0583	DNA-binding transcription factor activity
PPS_RS22300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PPS_RS22305	COG3622	Belongs to the hyi family
PPS_RS22345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS22350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPS_RS22360	COG3642	lipopolysaccharide core region biosynthetic process
PPS_RS22385	COG0459	protein refolding
PPS_RS22390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PPS_RS22425	COG0668	transmembrane transport
PPS_RS22430	COG1666	GTP binding
PPS_RS22445	COG2096	Adenosyltransferase
PPS_RS22450	COG0352	thiamine-phosphate diphosphorylase activity
PPS_RS22460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PPS_RS22465	COG0653	protein targeting
PPS_RS22475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PPS_RS22480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PPS_RS22495	COG1181	Belongs to the D-alanine--D-alanine ligase family
PPS_RS22500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPS_RS22505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPS_RS22510	COG0772	Belongs to the SEDS family
PPS_RS22515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PPS_RS22520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPS_RS22525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PPS_RS22530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PPS_RS22545	COG0275	rRNA processing
PPS_RS22550	COG2001	Belongs to the MraZ family
PPS_RS22560	COG3107	peptidoglycan biosynthetic process
PPS_RS22565	COG0792	nuclease activity
PPS_RS22570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PPS_RS22575	COG2823	Periplasmic or secreted lipoprotein
PPS_RS22585	COG2969	positive regulation of protein catabolic process
PPS_RS22590	COG0625	glutathione transferase activity
PPS_RS22595	COG2857	Cytochrome c1
PPS_RS22600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PPS_RS22605	COG0723	plastoquinol--plastocyanin reductase activity
PPS_RS22610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PPS_RS22615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PPS_RS22620	COG0667	Aldo Keto reductase
PPS_RS22630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PPS_RS22635	COG0180	Tryptophanyl-tRNA synthetase
PPS_RS22655	COG1522	sequence-specific DNA binding
PPS_RS22665	COG0175	sulfate reduction
PPS_RS22675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPS_RS22680	COG1126	abc transporter atp-binding protein
PPS_RS22685	COG0765	amino acid transport
PPS_RS22690	COG4597	amino acid ABC transporter
PPS_RS22695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPS_RS22700	COG0400	carboxylic ester hydrolase activity
PPS_RS22705	COG0513	Belongs to the DEAD box helicase family
PPS_RS22715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PPS_RS22720	COG0315	cyclic pyranopterin monophosphate synthase activity
PPS_RS22725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PPS_RS22735	COG3022	response to hydroperoxide
PPS_RS22740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PPS_RS22745	COG1215	transferase activity, transferring glycosyl groups
PPS_RS22750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS22755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PPS_RS22765	COG3420	alginic acid biosynthetic process
PPS_RS22780	COG1696	Membrane protein involved in D-alanine export
PPS_RS22795	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPS_RS22795	COG0662	Cupin 2, conserved barrel domain protein
PPS_RS22805	COG0300	oxidoreductase activity
PPS_RS22810	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS22840	COG1566	PFAM secretion protein HlyD family protein
PPS_RS22860	COG0583	DNA-binding transcription factor activity
PPS_RS22865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPS_RS22880	COG3708	Transcriptional regulator
PPS_RS22880	COG2207	Transcriptional regulator
PPS_RS22955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PPS_RS22965	COG1028	Short-chain dehydrogenase reductase Sdr
PPS_RS22980	COG0596	Alpha beta hydrolase
PPS_RS22985	COG1346	cytolysis
PPS_RS22990	COG1380	Effector of murein hydrolase LrgA
PPS_RS22995	COG0583	DNA-binding transcription factor activity
PPS_RS23005	COG1366	Belongs to the anti-sigma-factor antagonist family
PPS_RS23045	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPS_RS23065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PPS_RS23075	COG0523	cobalamin synthesis protein
PPS_RS23080	COG2879	small protein
PPS_RS23085	COG1966	Carbon starvation protein
PPS_RS23095	COG2233	PERMEase
PPS_RS23105	COG1970	mechanosensitive ion channel activity
PPS_RS23115	COG2197	response regulator
PPS_RS23120	COG2813	Specifically methylates the guanine in position
PPS_RS23130	COG1294	oxidase, subunit
PPS_RS23135	COG1271	oxidase subunit
PPS_RS23145	COG2252	PERMEase
PPS_RS23150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPS_RS23155	COG3485	protocatechuate 3,4-dioxygenase
PPS_RS23160	COG3485	protocatechuate 3,4-dioxygenase
PPS_RS23165	COG2321	neutral zinc metallopeptidase
PPS_RS23170	COG0840	transmembrane signaling receptor activity
PPS_RS23180	COG0583	DNA-binding transcription factor activity
PPS_RS23185	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPS_RS23205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PPS_RS23210	COG2267	carboxylic ester hydrolase activity
PPS_RS23215	COG2453	phosphatase
PPS_RS23215	COG0671	phosphoesterase, PA-phosphatase related
PPS_RS23230	COG4589	Belongs to the CDS family
PPS_RS23250	COG0110	maltose O-acetyltransferase activity
PPS_RS23275	COG3039	Transposase
PPS_RS23300	COG2199	diguanylate cyclase activity
PPS_RS23310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PPS_RS23315	COG1074	ATP-dependent DNA helicase activity
PPS_RS23320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PPS_RS23340	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PPS_RS23345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PPS_RS23350	COG1183	phosphatidylcholine synthase activity
PPS_RS23355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PPS_RS23365	COG0028	Belongs to the TPP enzyme family
PPS_RS23370	COG3098	single-species biofilm formation
PPS_RS23380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPS_RS23400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PPS_RS23405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPS_RS23410	COG4558	Periplasmic binding protein
PPS_RS23420	COG1489	DNA binding
PPS_RS23425	COG0436	Aminotransferase
PPS_RS23435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPS_RS23445	COG4191	Histidine kinase
PPS_RS23455	COG0617	tRNA 3'-terminal CCA addition
PPS_RS23465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PPS_RS23470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PPS_RS23485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPS_RS23510	COG2823	Periplasmic or secreted lipoprotein
PPS_RS23515	COG1185	polyribonucleotide nucleotidyltransferase activity
PPS_RS23520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PPS_RS23525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PPS_RS23530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PPS_RS23535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PPS_RS23540	COG0195	Participates in both transcription termination and antitermination
PPS_RS23545	COG0779	Required for maturation of 30S ribosomal subunits
PPS_RS23560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPS_RS23565	COG0149	triose-phosphate isomerase activity
PPS_RS23570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPS_RS23575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PPS_RS23585	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PPS_RS23600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPS_RS23605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PPS_RS23610	COG0505	Belongs to the CarA family
PPS_RS23615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PPS_RS23620	COG0484	heat shock protein binding
PPS_RS23625	COG0443	Heat shock 70 kDa protein
PPS_RS23630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PPS_RS23635	COG0497	DNA recombination
PPS_RS23640	COG0735	belongs to the Fur family
PPS_RS23645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PPS_RS23655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PPS_RS23665	COG1620	l-lactate permease
PPS_RS23670	COG1304	FMN binding
PPS_RS23755	COG3321	synthase
PPS_RS23755	COG0604	alcohol dehydrogenase
PPS_RS23760	COG0546	phosphoglycolate phosphatase activity
PPS_RS23765	COG1946	Acyl-CoA thioesterase
PPS_RS23780	COG0123	including yeast histone deacetylase and acetoin utilization protein
PPS_RS23790	COG0513	Belongs to the DEAD box helicase family
PPS_RS23795	COG0697	spore germination
PPS_RS23800	COG1522	sequence-specific DNA binding
PPS_RS23805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPS_RS23815	COG3416	Protein conserved in bacteria
PPS_RS23830	COG1643	Atp-dependent helicase
PPS_RS23850	COG1522	sequence-specific DNA binding
PPS_RS23865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPS_RS23870	COG1960	acyl-CoA dehydrogenase activity
PPS_RS23885	COG3328	transposase activity
PPS_RS23890	COG2205	protein histidine kinase activity
PPS_RS23890	COG3437	response regulator, receiver
PPS_RS23890	COG3850	Histidine kinase
PPS_RS23890	COG4999	Histidine kinase
PPS_RS23895	COG0351	phosphomethylpyrimidine kinase
PPS_RS23900	COG0352	thiamine-phosphate diphosphorylase activity
PPS_RS23905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPS_RS23920	COG1702	phosphate starvation-inducible protein PhoH
PPS_RS23925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PPS_RS23930	COG4535	Mg2 and Co2 transporter CorC
PPS_RS23935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PPS_RS23950	COG0495	leucyl-tRNA aminoacylation
PPS_RS23970	COG2951	lytic endotransglycosylase activity
PPS_RS23975	COG1619	proteins homologs of microcin C7 resistance protein MccF
PPS_RS23980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PPS_RS23985	COG0321	lipoyl(octanoyl) transferase activity
PPS_RS23990	COG2921	Belongs to the UPF0250 family
PPS_RS23995	COG1686	Belongs to the peptidase S11 family
PPS_RS24005	COG2951	lytic endotransglycosylase activity
PPS_RS24010	COG0772	Belongs to the SEDS family
PPS_RS24015	COG0768	penicillin binding
PPS_RS24020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PPS_RS24030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PPS_RS24035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PPS_RS24040	COG2094	Belongs to the DNA glycosylase MPG family
PPS_RS24045	COG0586	Pfam SNARE associated Golgi protein
PPS_RS24055	COG1346	cytolysis
PPS_RS24070	COG2264	protein methyltransferase activity
PPS_RS24080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPS_RS24090	COG0138	bifunctional purine biosynthesis protein purh
PPS_RS24095	COG0151	Belongs to the GarS family
PPS_RS24105	COG2095	MarC family integral membrane protein
PPS_RS24135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPS_RS24145	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PPS_RS24160	COG0330	HflC and HflK could
PPS_RS24185	COG4774	siderophore transport
PPS_RS24195	COG1113	amino acid transport
PPS_RS24215	COG0411	ABC transporter
PPS_RS24230	COG0789	Transcriptional regulator
PPS_RS24235	COG0484	heat shock protein binding
PPS_RS24240	COG0443	Heat shock 70 kDa protein
PPS_RS24260	COG0697	spore germination
PPS_RS24265	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PPS_RS24280	COG2982	Protein involved in outer membrane biogenesis
PPS_RS24300	COG4221	oxidoreductase activity
PPS_RS24330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PPS_RS24335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PPS_RS24350	COG1032	radical SAM domain protein
PPS_RS24355	COG0305	Participates in initiation and elongation during chromosome replication
PPS_RS24360	COG0359	binds to the 23S rRNA
PPS_RS24370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PPS_RS24375	COG0360	Binds together with S18 to 16S ribosomal RNA
PPS_RS24380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPS_RS24385	COG0557	exoribonuclease II activity
PPS_RS24400	COG1840	ABC-type Fe3 transport system, periplasmic component
PPS_RS24405	COG1178	ABC-type Fe3 transport system permease component
PPS_RS24445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PPS_RS24450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PPS_RS24455	COG0330	HflC and HflK could
PPS_RS24460	COG0330	HflC and HflK could
PPS_RS24465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PPS_RS24470	COG1923	regulation of RNA biosynthetic process
PPS_RS24475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PPS_RS24480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PPS_RS24485	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPS_RS24490	COG0802	atpase or kinase
PPS_RS24495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PPS_RS24495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PPS_RS24505	COG2860	membrane
PPS_RS24510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PPS_RS24515	COG1162	GTPase activity
PPS_RS24525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PPS_RS24540	COG0688	phosphatidylethanolamine metabolic process
PPS_RS24545	COG0560	Phosphoserine phosphatase
PPS_RS24545	COG3830	Belongs to the UPF0237 family
PPS_RS24565	COG3577	Aspartyl protease
PPS_RS24580	COG3150	esterase
PPS_RS24585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PPS_RS24595	COG0494	nUDIX hydrolase
PPS_RS24610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPS_RS24615	COG1538	Outer membrane efflux protein
PPS_RS24625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS24630	COG2274	protein secretion by the type I secretion system
PPS_RS24635	COG1519	Transferase
PPS_RS24640	COG0583	DNA-binding transcription factor activity
PPS_RS24660	COG0667	Aldo Keto reductase
PPS_RS24670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PPS_RS24670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PPS_RS24675	COG1132	(ABC) transporter
PPS_RS24690	COG0438	transferase activity, transferring glycosyl groups
PPS_RS24715	COG0438	transferase activity, transferring glycosyl groups
PPS_RS24720	COG2192	nodulation
PPS_RS24725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PPS_RS24730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PPS_RS24735	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PPS_RS24735	COG0506	proline dehydrogenase activity
PPS_RS24735	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PPS_RS24750	COG1960	acyl-CoA dehydrogenase activity
PPS_RS24760	COG0312	modulator of DNA gyrase
PPS_RS24765	COG0477	Major facilitator Superfamily
PPS_RS24770	COG0513	Belongs to the DEAD box helicase family
PPS_RS24775	COG2081	HI0933 family
PPS_RS24780	COG1289	transmembrane transporter activity
PPS_RS24790	COG2153	protein acetylation
PPS_RS24800	COG1451	nucleotide metabolic process
PPS_RS24805	COG5001	Diguanylate cyclase
PPS_RS24805	COG3300	MHYT domain
PPS_RS24825	COG0126	phosphoglycerate kinase activity
PPS_RS24830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PPS_RS24835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PPS_RS24840	COG0640	Transcriptional regulator
PPS_RS24845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PPS_RS24850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPS_RS24890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PPS_RS24895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PPS_RS24910	COG0513	Belongs to the DEAD box helicase family
PPS_RS24915	COG2353	YceI-like domain
PPS_RS24920	COG3038	cytochrome b561
PPS_RS24935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PPS_RS24940	COG1272	protein, Hemolysin III
PPS_RS24950	COG0643	Histidine kinase
PPS_RS24950	COG0784	Response regulator, receiver
PPS_RS24950	COG2198	Histidine kinase
PPS_RS24975	COG0189	ligase activity
PPS_RS24985	COG1678	Uncharacterized ACR, COG1678
PPS_RS24990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PPS_RS24995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PPS_RS25000	COG0540	Belongs to the ATCase OTCase family
PPS_RS25005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PPS_RS25010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PPS_RS25015	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PPS_RS25060	COG2226	methyltransferase
PPS_RS25070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PPS_RS25075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PPS_RS25080	COG0140	phosphoribosyl-ATP diphosphatase activity
PPS_RS25085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPS_RS25105	COG0840	transmembrane signaling receptor activity
PPS_RS25110	COG0840	transmembrane signaling receptor activity
PPS_RS25115	COG1126	abc transporter atp-binding protein
PPS_RS25120	COG0765	amino acid transport
PPS_RS25130	COG2943	transferase activity, transferring hexosyl groups
PPS_RS25135	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PPS_RS25140	COG1490	D-aminoacyl-tRNA deacylase activity
PPS_RS25160	COG1228	amidohydrolase
PPS_RS25170	COG2986	histidine ammonia-lyase
PPS_RS25175	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PPS_RS25185	COG2188	Transcriptional regulator
PPS_RS25190	COG0402	S-adenosylhomocysteine deaminase activity
PPS_RS25210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PPS_RS25215	COG0058	SHG alpha-glucan phosphorylase activity
PPS_RS25235	COG1217	gtp-binding protein TYPA
PPS_RS25240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPS_RS25240	COG0301	tRNA thio-modification
PPS_RS25260	COG3852	Histidine kinase
PPS_RS25275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PPS_RS25280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PPS_RS25290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPS_RS25295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PPS_RS25300	COG4942	peptidase
PPS_RS25305	COG0793	Belongs to the peptidase S41A family
PPS_RS25310	COG2861	carbohydrate metabolic process
PPS_RS25320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PPS_RS25325	COG1309	transcriptional regulator
PPS_RS25330	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS25335	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PPS_RS25340	COG3263	regulation of cellular component size
PPS_RS25345	COG3264	Mechanosensitive ion channel
PPS_RS25345	COG1196	nuclear chromosome segregation
PPS_RS25350	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PPS_RS25355	COG3118	belongs to the thioredoxin family
PPS_RS25360	COG1192	Involved in chromosome partitioning
PPS_RS25365	COG0583	DNA-binding transcription factor activity
PPS_RS25370	COG2814	Major facilitator Superfamily
PPS_RS25380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PPS_RS25385	COG0493	'glutamate synthase
PPS_RS25390	COG0067	glutamate synthase
PPS_RS25390	COG0069	glutamate synthase activity
PPS_RS25390	COG0070	glutamate synthase
PPS_RS25400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPS_RS25405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PPS_RS25435	COG0281	malic enzyme
PPS_RS25445	COG0254	rRNA binding
PPS_RS25450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPS_RS25455	COG0018	arginyl-trna synthetase
PPS_RS25470	COG0791	NLP P60 protein
PPS_RS25495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPS_RS25500	COG2813	Specifically methylates the guanine in position
PPS_RS25500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPS_RS25510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PPS_RS25515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPS_RS25525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PPS_RS25530	COG2022	thiamine diphosphate biosynthetic process
PPS_RS25540	COG2363	Small membrane protein
PPS_RS25545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPS_RS25555	COG2177	Part of the ABC transporter FtsEX involved in
PPS_RS25560	COG2884	Cell division ATP-binding protein ftsE
PPS_RS25565	COG0552	protein localization to endoplasmic reticulum
PPS_RS25570	COG0612	Peptidase, M16
PPS_RS25575	COG0612	Peptidase, M16
PPS_RS25580	COG0742	ribosomal rna small subunit methyltransferase
PPS_RS25590	COG0612	Peptidase, M16
PPS_RS25620	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PPS_RS25625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PPS_RS25630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPS_RS25635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PPS_RS25645	COG0693	protein deglycase activity
PPS_RS25650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PPS_RS25655	COG0129	dihydroxy-acid dehydratase activity
PPS_RS25660	COG0583	DNA-binding transcription factor activity
PPS_RS25675	COG1823	symporter activity
PPS_RS25690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPS_RS25700	COG1840	ABC-type Fe3 transport system, periplasmic component
PPS_RS25705	COG1178	ABC-type Fe3 transport system permease component
PPS_RS25710	COG3842	ATPase activity
PPS_RS25725	COG0789	Transcriptional regulator
PPS_RS25730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PPS_RS25735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PPS_RS25740	COG0730	response to heat
PPS_RS25750	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PPS_RS25755	COG0494	nUDIX hydrolase
PPS_RS25770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PPS_RS25775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PPS_RS25785	COG3204	pilus organization
PPS_RS25790	COG3204	pilus organization
PPS_RS25795	COG0179	Fumarylacetoacetate (FAA) hydrolase
PPS_RS25800	COG0277	FAD linked oxidase domain protein
PPS_RS25805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPS_RS25820	COG1683	Conserved Protein
PPS_RS25865	COG2267	carboxylic ester hydrolase activity
PPS_RS25885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PPS_RS25890	COG4208	sulfate ABC transporter
PPS_RS25900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PPS_RS25910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPS_RS25935	COG1177	transmembrane transport
PPS_RS25940	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPS_RS25945	COG3842	ATPase activity
PPS_RS25965	COG0174	glutamine synthetase
PPS_RS25975	COG0174	glutamine synthetase
PPS_RS25980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PPS_RS25980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PPS_RS25985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PPS_RS25995	COG1522	sequence-specific DNA binding
PPS_RS26005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PPS_RS26015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPS_RS26015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPS_RS26020	COG0509	glycine decarboxylation via glycine cleavage system
PPS_RS26025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPS_RS26030	COG1178	ABC-type Fe3 transport system permease component
PPS_RS26040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PPS_RS26050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PPS_RS26055	COG0006	proline dipeptidase activity
PPS_RS26060	COG3079	Belongs to the UPF0149 family
PPS_RS26075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PPS_RS26085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPS_RS26090	COG0842	Transport permease protein
PPS_RS26090	COG1129	ABC transporter
PPS_RS26095	COG0842	Transport permease protein
PPS_RS26120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPS_RS26135	COG0248	Ppx GppA phosphatase
PPS_RS26140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PPS_RS26155	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PPS_RS26160	COG1671	Belongs to the UPF0178 family
PPS_RS26165	COG3072	Adenylate cyclase
PPS_RS26170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPS_RS26180	COG1965	Belongs to the frataxin family
PPS_RS26190	COG0019	diaminopimelate decarboxylase activity
PPS_RS26195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PPS_RS26205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PPS_RS26210	COG0546	phosphoglycolate phosphatase activity
PPS_RS26220	COG0004	ammonium transporteR
PPS_RS26225	COG0347	Belongs to the P(II) protein family
PPS_RS26240	COG0606	chelatase, subunit chli
PPS_RS26245	COG4566	intracellular signal transduction
PPS_RS26250	COG4566	intracellular signal transduction
PPS_RS26255	COG4191	Histidine kinase
PPS_RS26260	COG1335	isochorismatase
PPS_RS26285	COG1335	isochorismatase
PPS_RS26290	COG0583	DNA-binding transcription factor activity
PPS_RS26300	COG0477	Major facilitator Superfamily
PPS_RS26320	COG1335	isochorismatase
PPS_RS26330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS26335	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS26340	COG0583	DNA-binding transcription factor activity
PPS_RS26345	COG5383	Protein conserved in bacteria
PPS_RS26355	COG0534	Mate efflux family protein
PPS_RS26370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPS_RS26375	COG0427	acetyl-CoA hydrolase
PPS_RS26395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS26410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPS_RS26420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPS_RS26425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPS_RS26435	COG1012	belongs to the aldehyde dehydrogenase family
PPS_RS26445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PPS_RS26455	COG0747	negative chemotaxis
PPS_RS26460	COG2003	Belongs to the UPF0758 family
PPS_RS26465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPS_RS26470	COG0756	dUTP diphosphatase activity
PPS_RS26475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPS_RS26480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PPS_RS26485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PPS_RS26490	COG0708	Exodeoxyribonuclease III
PPS_RS26500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PPS_RS26505	COG1561	YicC-like family, N-terminal region
PPS_RS26510	COG0194	GDP metabolic process
PPS_RS26520	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PPS_RS26525	COG0174	glutamine synthetase
PPS_RS26535	COG1758	RNA polymerase activity
PPS_RS26540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPS_RS26565	COG0848	biopolymer transport protein
PPS_RS26575	COG0583	DNA-binding transcription factor activity
PPS_RS26580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PPS_RS26610	COG3161	chorismate lyase activity
PPS_RS26615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPS_RS26635	COG1253	flavin adenine dinucleotide binding
PPS_RS26640	COG0739	heme binding
PPS_RS26650	COG0704	Plays a role in the regulation of phosphate uptake
PPS_RS26655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPS_RS26660	COG0581	inorganic phosphate transmembrane transporter activity
PPS_RS26675	COG0477	Major facilitator Superfamily
PPS_RS26680	COG1607	acyl-coa hydrolase
PPS_RS26715	COG0583	DNA-binding transcription factor activity
PPS_RS26720	COG1027	Aspartate ammonia-lyase
PPS_RS26760	COG5016	pyruvate
PPS_RS26760	COG0511	ligase activity, forming carbon-carbon bonds
PPS_RS26765	COG0439	Biotin carboxylase
PPS_RS26770	COG0583	DNA-binding transcription factor activity
PPS_RS26780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPS_RS26790	COG0210	DNA helicase
PPS_RS26805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PPS_RS26805	COG4651	solute:proton antiporter activity
PPS_RS26810	COG1607	acyl-coa hydrolase
PPS_RS26815	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PPS_RS26825	COG0523	cobalamin synthesis protein
PPS_RS26840	COG1469	GTP cyclohydrolase I activity
PPS_RS26850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPS_RS26855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PPS_RS26860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPS_RS26870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PPS_RS26880	COG0431	NADPH-dependent FMN reductase
PPS_RS26885	COG0798	PFAM Bile acid sodium symporter
PPS_RS26890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPS_RS26895	COG0640	Transcriptional regulator
PPS_RS26910	COG2072	flavoprotein involved in K transport
PPS_RS26915	COG2194	sulfuric ester hydrolase activity
PPS_RS26930	COG4644	lycopene metabolic process
PPS_RS26935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PPS_RS26950	COG0789	Transcriptional regulator
PPS_RS26960	COG2608	mercury ion transmembrane transporter activity
PPS_RS26965	COG2608	mercury ion transmembrane transporter activity
PPS_RS26970	COG0789	Transcriptional regulator
PPS_RS27050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PPS_RS27085	COG2132	Multicopper oxidase
PPS_RS27150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PPS_RS27155	COG1349	DNA-binding transcription factor activity
PPS_RS27160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPS_RS27165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PPS_RS27170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPS_RS27175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PPS_RS27180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPS_RS27185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPS_RS27190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPS_RS27200	COG0356	it plays a direct role in the translocation of protons across the membrane
PPS_RS27205	COG3312	ion transport
PPS_RS27285	COG0840	transmembrane signaling receptor activity