locus-tag	class	description
IGB31_RS00175	COG1192	Involved in chromosome partitioning
IGB31_RS00185	COG2197	response regulator
IGB31_RS00190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS00190	COG2205	protein histidine kinase activity
IGB31_RS00195	COG3171	Protein conserved in bacteria
IGB31_RS00200	COG2027	D-alanyl-D-alanine carboxypeptidase
IGB31_RS00210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IGB31_RS00210	COG0116	Belongs to the methyltransferase superfamily
IGB31_RS00215	COG3130	regulation of translation
IGB31_RS00220	COG0167	dihydroorotate dehydrogenase activity
IGB31_RS00225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IGB31_RS00225	COG1116	anion transmembrane transporter activity
IGB31_RS00230	COG3707	response regulator
IGB31_RS00235	COG2223	nitrite transmembrane transporter activity
IGB31_RS00240	COG0515	serine threonine protein kinase
IGB31_RS00260	COG0668	transmembrane transport
IGB31_RS00275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGB31_RS00290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IGB31_RS00305	COG0583	DNA-binding transcription factor activity
IGB31_RS00310	COG0019	diaminopimelate decarboxylase activity
IGB31_RS00350	COG1609	Transcriptional regulator
IGB31_RS00355	COG0789	Transcriptional regulator
IGB31_RS00360	COG3237	CsbD-like
IGB31_RS00370	COG0246	Mannitol dehydrogenase
IGB31_RS00380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGB31_RS00395	COG0714	Associated with various cellular activities
IGB31_RS00425	COG0420	3'-5' exonuclease activity
IGB31_RS00440	COG2706	6-phosphogluconolactonase activity
IGB31_RS00460	COG0308	aminopeptidase N
IGB31_RS00470	COG3139	Protein of unknown function (DUF1315)
IGB31_RS00475	COG0705	Rhomboid family
IGB31_RS00480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGB31_RS00485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IGB31_RS00495	COG3038	cytochrome b561
IGB31_RS00505	COG1902	pentaerythritol trinitrate reductase activity
IGB31_RS00505	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGB31_RS00520	COG0789	Transcriptional regulator
IGB31_RS00535	COG2851	Citrate transporter
IGB31_RS00540	COG1301	dicarboxylic acid transport
IGB31_RS00545	COG2828	Protein conserved in bacteria
IGB31_RS00550	COG0583	DNA-binding transcription factor activity
IGB31_RS00625	COG1286	toxin biosynthetic process
IGB31_RS00635	COG0285	dihydrofolate synthase activity
IGB31_RS00640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IGB31_RS00645	COG0135	phosphoribosylanthranilate isomerase activity
IGB31_RS00670	COG0473	3-isopropylmalate dehydrogenase activity
IGB31_RS00675	COG2226	methyltransferase
IGB31_RS00680	COG0066	3-isopropylmalate dehydratase activity
IGB31_RS00685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IGB31_RS00705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IGB31_RS00745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGB31_RS00760	COG0556	nucleotide-excision repair
IGB31_RS00795	COG0084	hydrolase, TatD family'
IGB31_RS00805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGB31_RS00810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IGB31_RS00820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGB31_RS00825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGB31_RS00840	COG0416	fatty acid biosynthetic process
IGB31_RS00845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGB31_RS00855	COG0424	maF-like protein
IGB31_RS00860	COG0616	signal peptide processing
IGB31_RS00860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGB31_RS00865	COG0546	phosphoglycolate phosphatase activity
IGB31_RS00875	COG1530	ribonuclease E activity
IGB31_RS00880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IGB31_RS00885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGB31_RS00890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IGB31_RS00895	COG2835	tetraacyldisaccharide 4'-kinase activity
IGB31_RS00900	COG1663	tetraacyldisaccharide 4'-kinase activity
IGB31_RS00905	COG0848	biopolymer transport protein
IGB31_RS00910	COG0811	peptide transport
IGB31_RS00915	COG2333	competence protein COMEC
IGB31_RS00915	COG0658	competence protein
IGB31_RS00925	COG0842	Transport permease protein
IGB31_RS00930	COG1131	(ABC) transporter
IGB31_RS00935	COG0625	glutathione transferase activity
IGB31_RS00960	COG3121	Chaperone
IGB31_RS00965	COG3539	Fimbrial protein
IGB31_RS01040	COG1956	GAF domain-containing protein
IGB31_RS01050	COG2205	protein histidine kinase activity
IGB31_RS01050	COG3437	response regulator, receiver
IGB31_RS01050	COG3850	Histidine kinase
IGB31_RS01050	COG4999	Histidine kinase
IGB31_RS01055	COG0386	Belongs to the glutathione peroxidase family
IGB31_RS01060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGB31_RS01065	COG0436	Aminotransferase
IGB31_RS01070	COG0501	Belongs to the peptidase M48B family
IGB31_RS01075	COG0500	methyltransferase
IGB31_RS01080	COG3384	dioxygenase
IGB31_RS01095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IGB31_RS01105	COG0583	DNA-binding transcription factor activity
IGB31_RS01110	COG1846	Transcriptional regulator
IGB31_RS01115	COG1764	response to oxidative stress
IGB31_RS01120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IGB31_RS01140	COG0583	DNA-binding transcription factor activity
IGB31_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS01150	COG2814	Major facilitator Superfamily
IGB31_RS01175	COG0598	Magnesium transport protein CorA
IGB31_RS01180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IGB31_RS01190	COG0531	amino acid
IGB31_RS01195	COG0840	transmembrane signaling receptor activity
IGB31_RS01240	COG0531	amino acid
IGB31_RS01245	COG1733	regulation of RNA biosynthetic process
IGB31_RS01260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IGB31_RS01265	COG0602	queuosine metabolic process
IGB31_RS01270	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IGB31_RS01275	COG2885	chlorophyll binding
IGB31_RS01280	COG0823	Involved in the tonB-independent uptake of proteins
IGB31_RS01300	COG0824	Thioesterase
IGB31_RS01305	COG2255	four-way junction helicase activity
IGB31_RS01310	COG0632	four-way junction helicase activity
IGB31_RS01315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IGB31_RS01320	COG0217	transcriptional regulatory protein
IGB31_RS01325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGB31_RS01340	COG0783	Belongs to the Dps family
IGB31_RS01350	COG2900	Belongs to the SlyX family
IGB31_RS01365	COG0442	prolyl-tRNA aminoacylation
IGB31_RS01375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGB31_RS01405	COG3158	transport of potassium into the cell
IGB31_RS01410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGB31_RS01415	COG1214	PFAM Peptidase M22, glycoprotease
IGB31_RS01415	COG0456	acetyltransferase
IGB31_RS01425	COG4807	Protein conserved in bacteria
IGB31_RS01445	COG1301	dicarboxylic acid transport
IGB31_RS01475	COG2205	protein histidine kinase activity
IGB31_RS01480	COG0745	RESPONSE REGULATOR receiver
IGB31_RS01485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGB31_RS01485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGB31_RS01490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGB31_RS01495	COG3621	Patatin-like phospholipase
IGB31_RS01505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IGB31_RS01560	COG1414	Transcriptional regulator
IGB31_RS01565	COG2271	Major facilitator Superfamily
IGB31_RS01570	COG4948	Mandelate Racemase Muconate Lactonizing
IGB31_RS01575	COG0800	Aldolase
IGB31_RS01580	COG3734	2-keto-3-deoxy-galactonokinase
IGB31_RS01595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGB31_RS01605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IGB31_RS01640	COG0625	glutathione transferase activity
IGB31_RS01650	COG0252	asparaginase activity
IGB31_RS01660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGB31_RS01700	COG2116	formate transmembrane transporter activity
IGB31_RS01710	COG3706	GGDEF domain
IGB31_RS01715	COG5001	Diguanylate cyclase
IGB31_RS01715	COG3300	MHYT domain
IGB31_RS01725	COG0583	DNA-binding transcription factor activity
IGB31_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS01745	COG1289	transmembrane transporter activity
IGB31_RS01765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGB31_RS01775	COG2084	Dehydrogenase
IGB31_RS01815	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IGB31_RS01830	COG0259	pyridoxamine-phosphate oxidase activity
IGB31_RS01835	COG2885	chlorophyll binding
IGB31_RS01850	COG1199	ATP-dependent helicase activity
IGB31_RS01880	COG3012	SEC-C Motif Domain Protein
IGB31_RS01890	COG0653	protein targeting
IGB31_RS01900	COG2814	Major facilitator Superfamily
IGB31_RS01910	COG1045	serine acetyltransferase
IGB31_RS01915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS01920	COG2366	antibiotic biosynthetic process
IGB31_RS01925	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IGB31_RS01925	COG1793	dna ligase
IGB31_RS01930	COG1793	dna ligase
IGB31_RS01940	COG1201	RNA secondary structure unwinding
IGB31_RS01955	COG0717	Belongs to the dCTP deaminase family
IGB31_RS01960	COG1278	Cold shock
IGB31_RS01965	COG0489	protein tyrosine kinase activity
IGB31_RS01970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGB31_RS01970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGB31_RS01975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IGB31_RS01985	COG2197	response regulator
IGB31_RS01995	COG0137	argininosuccinate synthase activity
IGB31_RS02005	COG0418	dihydroorotase activity
IGB31_RS02010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGB31_RS02015	COG0450	alkyl hydroperoxide reductase
IGB31_RS02030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IGB31_RS02035	COG0243	molybdopterin cofactor binding
IGB31_RS02040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGB31_RS02045	COG3842	ATPase activity
IGB31_RS02050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IGB31_RS02060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGB31_RS02090	COG0765	amino acid transport
IGB31_RS02095	COG0765	amino acid transport
IGB31_RS02100	COG1126	abc transporter atp-binding protein
IGB31_RS02115	COG0583	DNA-binding transcription factor activity
IGB31_RS02125	COG1201	RNA secondary structure unwinding
IGB31_RS02130	COG0069	glutamate synthase activity
IGB31_RS02135	COG1113	amino acid transport
IGB31_RS02145	COG1695	Transcriptional regulator
IGB31_RS02150	COG2375	cellular response to nickel ion
IGB31_RS02160	COG4628	conserved protein (DUF2132)
IGB31_RS02165	COG4206	TonB-dependent receptor
IGB31_RS02180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGB31_RS02190	COG2226	methyltransferase
IGB31_RS02195	COG0500	methyltransferase
IGB31_RS02215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IGB31_RS02220	COG1381	Involved in DNA repair and RecF pathway recombination
IGB31_RS02225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGB31_RS02230	COG0571	ribonuclease III activity
IGB31_RS02235	COG0681	Belongs to the peptidase S26 family
IGB31_RS02240	COG0481	GTPase activity
IGB31_RS02245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGB31_RS02275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IGB31_RS02325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IGB31_RS02330	COG1024	Enoyl-CoA hydratase
IGB31_RS02355	COG2267	carboxylic ester hydrolase activity
IGB31_RS02400	COG4191	Histidine kinase
IGB31_RS02410	COG0477	Major facilitator Superfamily
IGB31_RS02440	COG2207	Transcriptional regulator
IGB31_RS02460	COG0583	DNA-binding transcription factor activity
IGB31_RS02465	COG2910	NAD(P)H-binding
IGB31_RS02480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IGB31_RS02485	COG0477	Major facilitator Superfamily
IGB31_RS02490	COG1309	transcriptional regulator
IGB31_RS02495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS02520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGB31_RS02525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGB31_RS02530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGB31_RS02535	COG0477	Major facilitator Superfamily
IGB31_RS02540	COG0183	Belongs to the thiolase family
IGB31_RS02545	COG2814	Major facilitator Superfamily
IGB31_RS02550	COG1414	Transcriptional regulator
IGB31_RS02560	COG0306	phosphate transporter
IGB31_RS02565	COG0433	COG0433 Predicted ATPase
IGB31_RS02570	COG0840	transmembrane signaling receptor activity
IGB31_RS02575	COG0438	transferase activity, transferring glycosyl groups
IGB31_RS02575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGB31_RS02590	COG0788	formyltetrahydrofolate deformylase activity
IGB31_RS02600	COG2925	Exonuclease
IGB31_RS02615	COG0469	pyruvate kinase activity
IGB31_RS02630	COG3153	acetyltransferase
IGB31_RS02630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGB31_RS02645	COG0693	protein deglycase activity
IGB31_RS02650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGB31_RS02680	COG1902	pentaerythritol trinitrate reductase activity
IGB31_RS02690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGB31_RS02695	COG0583	DNA-binding transcription factor activity
IGB31_RS02705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IGB31_RS02745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS02750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGB31_RS02760	COG3642	lipopolysaccharide core region biosynthetic process
IGB31_RS02770	COG0642	Histidine kinase
IGB31_RS02785	COG0459	protein refolding
IGB31_RS02790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGB31_RS02825	COG0668	transmembrane transport
IGB31_RS02830	COG1666	GTP binding
IGB31_RS02845	COG2096	Adenosyltransferase
IGB31_RS02850	COG0494	nUDIX hydrolase
IGB31_RS02855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IGB31_RS02860	COG0653	protein targeting
IGB31_RS02870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IGB31_RS02875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IGB31_RS02890	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGB31_RS02895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGB31_RS02900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGB31_RS02905	COG0772	Belongs to the SEDS family
IGB31_RS02910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGB31_RS02915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGB31_RS02920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IGB31_RS02925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGB31_RS02940	COG0275	rRNA processing
IGB31_RS02945	COG2001	Belongs to the MraZ family
IGB31_RS02960	COG3107	peptidoglycan biosynthetic process
IGB31_RS02965	COG0792	nuclease activity
IGB31_RS02970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IGB31_RS02975	COG2823	Periplasmic or secreted lipoprotein
IGB31_RS02980	COG2969	positive regulation of protein catabolic process
IGB31_RS02985	COG0625	glutathione transferase activity
IGB31_RS02990	COG2857	Cytochrome c1
IGB31_RS02995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGB31_RS03000	COG0723	plastoquinol--plastocyanin reductase activity
IGB31_RS03005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGB31_RS03010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGB31_RS03015	COG0667	Aldo Keto reductase
IGB31_RS03025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IGB31_RS03030	COG0180	Tryptophanyl-tRNA synthetase
IGB31_RS03065	COG0175	sulfate reduction
IGB31_RS03075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGB31_RS03080	COG1126	abc transporter atp-binding protein
IGB31_RS03085	COG0765	amino acid transport
IGB31_RS03090	COG4597	amino acid ABC transporter
IGB31_RS03095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS03100	COG0400	carboxylic ester hydrolase activity
IGB31_RS03105	COG0513	Belongs to the DEAD box helicase family
IGB31_RS03115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IGB31_RS03120	COG0315	cyclic pyranopterin monophosphate synthase activity
IGB31_RS03125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IGB31_RS03135	COG3022	response to hydroperoxide
IGB31_RS03140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGB31_RS03145	COG1215	transferase activity, transferring glycosyl groups
IGB31_RS03150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS03155	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IGB31_RS03165	COG3420	alginic acid biosynthetic process
IGB31_RS03180	COG1696	Membrane protein involved in D-alanine export
IGB31_RS03195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IGB31_RS03195	COG0662	Cupin 2, conserved barrel domain protein
IGB31_RS03205	COG0300	oxidoreductase activity
IGB31_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS03235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGB31_RS03240	COG0583	DNA-binding transcription factor activity
IGB31_RS03260	COG1566	PFAM secretion protein HlyD family protein
IGB31_RS03270	COG0583	DNA-binding transcription factor activity
IGB31_RS03310	COG4566	intracellular signal transduction
IGB31_RS03325	COG4964	Belongs to the GSP D family
IGB31_RS03390	COG3436	PFAM IS66 Orf2 family protein
IGB31_RS03440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IGB31_RS03460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IGB31_RS03470	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS03475	COG0596	Alpha beta hydrolase
IGB31_RS03480	COG1346	cytolysis
IGB31_RS03485	COG1380	Effector of murein hydrolase LrgA
IGB31_RS03490	COG0583	DNA-binding transcription factor activity
IGB31_RS03500	COG1366	Belongs to the anti-sigma-factor antagonist family
IGB31_RS03510	COG0789	Transcriptional regulator
IGB31_RS03535	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IGB31_RS03545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IGB31_RS03555	COG0523	cobalamin synthesis protein
IGB31_RS03560	COG2879	small protein
IGB31_RS03565	COG1966	Carbon starvation protein
IGB31_RS03575	COG2233	PERMEase
IGB31_RS03585	COG1970	mechanosensitive ion channel activity
IGB31_RS03595	COG2197	response regulator
IGB31_RS03600	COG2813	Specifically methylates the guanine in position
IGB31_RS03610	COG1294	oxidase, subunit
IGB31_RS03615	COG1271	oxidase subunit
IGB31_RS03625	COG2252	PERMEase
IGB31_RS03630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGB31_RS03645	COG3485	protocatechuate 3,4-dioxygenase
IGB31_RS03650	COG3485	protocatechuate 3,4-dioxygenase
IGB31_RS03655	COG2321	neutral zinc metallopeptidase
IGB31_RS03660	COG0840	transmembrane signaling receptor activity
IGB31_RS03670	COG0583	DNA-binding transcription factor activity
IGB31_RS03675	COG2249	NAD(P)H dehydrogenase (quinone) activity
IGB31_RS03695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IGB31_RS03700	COG2267	carboxylic ester hydrolase activity
IGB31_RS03705	COG0671	phosphoesterase, PA-phosphatase related
IGB31_RS03705	COG2453	phosphatase
IGB31_RS03720	COG4589	Belongs to the CDS family
IGB31_RS03750	COG2199	diguanylate cyclase activity
IGB31_RS03760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGB31_RS03765	COG1074	ATP-dependent DNA helicase activity
IGB31_RS03770	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IGB31_RS03790	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IGB31_RS03795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGB31_RS03800	COG1183	phosphatidylcholine synthase activity
IGB31_RS03805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IGB31_RS03815	COG0028	Belongs to the TPP enzyme family
IGB31_RS03830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGB31_RS03850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGB31_RS03855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGB31_RS03860	COG4558	Periplasmic binding protein
IGB31_RS03870	COG1489	DNA binding
IGB31_RS03875	COG0436	Aminotransferase
IGB31_RS03885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGB31_RS03905	COG4191	Histidine kinase
IGB31_RS03910	COG2204	response regulator
IGB31_RS03915	COG0617	tRNA 3'-terminal CCA addition
IGB31_RS03925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IGB31_RS03930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IGB31_RS03935	COG0166	Belongs to the GPI family
IGB31_RS03940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGB31_RS03965	COG2823	Periplasmic or secreted lipoprotein
IGB31_RS03970	COG1185	polyribonucleotide nucleotidyltransferase activity
IGB31_RS03975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGB31_RS03980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IGB31_RS03985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGB31_RS03990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IGB31_RS03995	COG0195	Participates in both transcription termination and antitermination
IGB31_RS04000	COG0779	Required for maturation of 30S ribosomal subunits
IGB31_RS04015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IGB31_RS04020	COG0149	triose-phosphate isomerase activity
IGB31_RS04025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGB31_RS04030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IGB31_RS04040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IGB31_RS04055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGB31_RS04060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGB31_RS04065	COG0505	Belongs to the CarA family
IGB31_RS04070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGB31_RS04075	COG0484	heat shock protein binding
IGB31_RS04080	COG0443	Heat shock 70 kDa protein
IGB31_RS04085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGB31_RS04090	COG0497	DNA recombination
IGB31_RS04110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGB31_RS04115	COG2186	Transcriptional regulator
IGB31_RS04120	COG1620	l-lactate permease
IGB31_RS04125	COG1304	FMN binding
IGB31_RS04260	COG0740	serine-type endopeptidase activity
IGB31_RS04265	COG4695	Portal protein
IGB31_RS04270	COG4626	Terminase
IGB31_RS04270	COG1802	Transcriptional regulator
IGB31_RS04325	COG0305	Participates in initiation and elongation during chromosome replication
IGB31_RS04330	COG1484	DNA-dependent DNA replication
IGB31_RS04395	COG3646	Phage regulatory protein
IGB31_RS04400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IGB31_RS04415	COG0582	viral genome integration into host DNA
IGB31_RS04425	COG0582	viral genome integration into host DNA
IGB31_RS04475	COG2003	Belongs to the UPF0758 family
IGB31_RS04505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IGB31_RS04510	COG1061	Type III restriction enzyme res subunit
IGB31_RS04515	COG1002	Type II restriction enzyme, methylase subunits
IGB31_RS04560	COG4774	siderophore transport
IGB31_RS04565	COG0784	Response regulator, receiver
IGB31_RS04565	COG4191	Histidine kinase
IGB31_RS04570	COG2205	protein histidine kinase activity
IGB31_RS04580	COG2172	sigma factor antagonist activity
IGB31_RS04585	COG1366	Belongs to the anti-sigma-factor antagonist family
IGB31_RS04590	COG1366	Belongs to the anti-sigma-factor antagonist family
IGB31_RS04610	COG1609	Transcriptional regulator
IGB31_RS04615	COG3321	synthase
IGB31_RS04615	COG0604	alcohol dehydrogenase
IGB31_RS04620	COG0546	phosphoglycolate phosphatase activity
IGB31_RS04625	COG1946	Acyl-CoA thioesterase
IGB31_RS04645	COG0123	including yeast histone deacetylase and acetoin utilization protein
IGB31_RS04655	COG0513	Belongs to the DEAD box helicase family
IGB31_RS04660	COG0697	spore germination
IGB31_RS04675	COG3416	Protein conserved in bacteria
IGB31_RS04685	COG1643	Atp-dependent helicase
IGB31_RS04720	COG1643	Atp-dependent helicase
IGB31_RS04740	COG1522	sequence-specific DNA binding
IGB31_RS04755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IGB31_RS04760	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS04765	COG5002	protein histidine kinase activity
IGB31_RS04765	COG2205	protein histidine kinase activity
IGB31_RS04765	COG0784	Response regulator, receiver
IGB31_RS04770	COG0351	phosphomethylpyrimidine kinase
IGB31_RS04775	COG0352	thiamine-phosphate diphosphorylase activity
IGB31_RS04780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IGB31_RS04790	COG1702	phosphate starvation-inducible protein PhoH
IGB31_RS04795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IGB31_RS04800	COG4535	Mg2 and Co2 transporter CorC
IGB31_RS04805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGB31_RS04820	COG0495	leucyl-tRNA aminoacylation
IGB31_RS04840	COG2951	lytic endotransglycosylase activity
IGB31_RS04845	COG1619	proteins homologs of microcin C7 resistance protein MccF
IGB31_RS04850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IGB31_RS04855	COG0321	lipoyl(octanoyl) transferase activity
IGB31_RS04860	COG2921	Belongs to the UPF0250 family
IGB31_RS04865	COG1686	Belongs to the peptidase S11 family
IGB31_RS04875	COG2951	lytic endotransglycosylase activity
IGB31_RS04880	COG0772	Belongs to the SEDS family
IGB31_RS04885	COG0768	penicillin binding
IGB31_RS04890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IGB31_RS04900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGB31_RS04905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGB31_RS04910	COG2094	Belongs to the DNA glycosylase MPG family
IGB31_RS04915	COG0586	Pfam SNARE associated Golgi protein
IGB31_RS04925	COG1346	cytolysis
IGB31_RS04940	COG2264	protein methyltransferase activity
IGB31_RS04950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IGB31_RS04960	COG0138	bifunctional purine biosynthesis protein purh
IGB31_RS04965	COG0151	Belongs to the GarS family
IGB31_RS04975	COG2095	MarC family integral membrane protein
IGB31_RS05010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGB31_RS05020	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IGB31_RS05035	COG0330	HflC and HflK could
IGB31_RS05055	COG4774	siderophore transport
IGB31_RS05065	COG1113	amino acid transport
IGB31_RS05085	COG0411	ABC transporter
IGB31_RS05100	COG0789	Transcriptional regulator
IGB31_RS05105	COG0484	heat shock protein binding
IGB31_RS05110	COG0443	Heat shock 70 kDa protein
IGB31_RS05125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IGB31_RS05140	COG2982	Protein involved in outer membrane biogenesis
IGB31_RS05160	COG4221	oxidoreductase activity
IGB31_RS05190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IGB31_RS05195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IGB31_RS05210	COG1032	radical SAM domain protein
IGB31_RS05225	COG0305	Participates in initiation and elongation during chromosome replication
IGB31_RS05230	COG0359	binds to the 23S rRNA
IGB31_RS05240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGB31_RS05245	COG0360	Binds together with S18 to 16S ribosomal RNA
IGB31_RS05250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGB31_RS05255	COG0557	exoribonuclease II activity
IGB31_RS05270	COG1840	ABC-type Fe3 transport system, periplasmic component
IGB31_RS05275	COG1178	ABC-type Fe3 transport system permease component
IGB31_RS05325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGB31_RS05330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IGB31_RS05335	COG0330	HflC and HflK could
IGB31_RS05340	COG0330	HflC and HflK could
IGB31_RS05345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGB31_RS05350	COG1923	regulation of RNA biosynthetic process
IGB31_RS05355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGB31_RS05360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IGB31_RS05365	COG0860	N-Acetylmuramoyl-L-alanine amidase
IGB31_RS05370	COG0802	atpase or kinase
IGB31_RS05375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IGB31_RS05375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IGB31_RS05385	COG2860	membrane
IGB31_RS05390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IGB31_RS05395	COG1162	GTPase activity
IGB31_RS05405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IGB31_RS05420	COG0688	phosphatidylethanolamine metabolic process
IGB31_RS05425	COG0560	Phosphoserine phosphatase
IGB31_RS05425	COG3830	Belongs to the UPF0237 family
IGB31_RS05445	COG3577	Aspartyl protease
IGB31_RS05460	COG3150	esterase
IGB31_RS05465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IGB31_RS05475	COG0494	nUDIX hydrolase
IGB31_RS05490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IGB31_RS05495	COG1538	Outer membrane efflux protein
IGB31_RS05500	COG1519	Transferase
IGB31_RS05505	COG0583	DNA-binding transcription factor activity
IGB31_RS05520	COG0667	Aldo Keto reductase
IGB31_RS05530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IGB31_RS05530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IGB31_RS05535	COG1132	(ABC) transporter
IGB31_RS05565	COG0438	transferase activity, transferring glycosyl groups
IGB31_RS05570	COG2192	nodulation
IGB31_RS05575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IGB31_RS05580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGB31_RS05585	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IGB31_RS05585	COG0506	proline dehydrogenase activity
IGB31_RS05585	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IGB31_RS05590	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS05600	COG0312	modulator of DNA gyrase
IGB31_RS05605	COG0477	Major facilitator Superfamily
IGB31_RS05610	COG0513	Belongs to the DEAD box helicase family
IGB31_RS05615	COG2081	HI0933 family
IGB31_RS05620	COG1289	transmembrane transporter activity
IGB31_RS05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS05635	COG1451	nucleotide metabolic process
IGB31_RS05660	COG0126	phosphoglycerate kinase activity
IGB31_RS05665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IGB31_RS05670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IGB31_RS05680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGB31_RS05685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGB31_RS05725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IGB31_RS05730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IGB31_RS05745	COG0513	Belongs to the DEAD box helicase family
IGB31_RS05750	COG2353	YceI-like domain
IGB31_RS05755	COG3038	cytochrome b561
IGB31_RS05770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IGB31_RS05775	COG1272	protein, Hemolysin III
IGB31_RS05785	COG0643	Histidine kinase
IGB31_RS05785	COG0784	Response regulator, receiver
IGB31_RS05785	COG2198	Histidine kinase
IGB31_RS05810	COG0189	ligase activity
IGB31_RS05820	COG1678	Uncharacterized ACR, COG1678
IGB31_RS05825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGB31_RS05830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IGB31_RS05835	COG0540	Belongs to the ATCase OTCase family
IGB31_RS05840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGB31_RS05845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IGB31_RS05850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IGB31_RS05900	COG2226	methyltransferase
IGB31_RS05910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IGB31_RS05915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IGB31_RS05920	COG0140	phosphoribosyl-ATP diphosphatase activity
IGB31_RS05925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGB31_RS05945	COG0840	transmembrane signaling receptor activity
IGB31_RS05950	COG0840	transmembrane signaling receptor activity
IGB31_RS05955	COG1126	abc transporter atp-binding protein
IGB31_RS05960	COG0765	amino acid transport
IGB31_RS05970	COG2943	transferase activity, transferring hexosyl groups
IGB31_RS05975	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IGB31_RS05980	COG1490	D-aminoacyl-tRNA deacylase activity
IGB31_RS06000	COG1228	amidohydrolase
IGB31_RS06010	COG2986	histidine ammonia-lyase
IGB31_RS06015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IGB31_RS06030	COG2188	Transcriptional regulator
IGB31_RS06035	COG0402	S-adenosylhomocysteine deaminase activity
IGB31_RS06055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IGB31_RS06060	COG0058	SHG alpha-glucan phosphorylase activity
IGB31_RS06070	COG1217	gtp-binding protein TYPA
IGB31_RS06075	COG0301	tRNA thio-modification
IGB31_RS06075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGB31_RS06090	COG3852	Histidine kinase
IGB31_RS06105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IGB31_RS06110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IGB31_RS06120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGB31_RS06125	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IGB31_RS06130	COG4942	peptidase
IGB31_RS06135	COG0793	Belongs to the peptidase S41A family
IGB31_RS06140	COG2861	carbohydrate metabolic process
IGB31_RS06150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IGB31_RS06155	COG1309	transcriptional regulator
IGB31_RS06160	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS06165	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IGB31_RS06170	COG3263	regulation of cellular component size
IGB31_RS06175	COG1196	nuclear chromosome segregation
IGB31_RS06175	COG3264	Mechanosensitive ion channel
IGB31_RS06180	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IGB31_RS06185	COG3118	belongs to the thioredoxin family
IGB31_RS06200	COG1192	Involved in chromosome partitioning
IGB31_RS06205	COG0583	DNA-binding transcription factor activity
IGB31_RS06210	COG2814	Major facilitator Superfamily
IGB31_RS06280	COG3397	chitin binding
IGB31_RS06285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IGB31_RS06290	COG0493	'glutamate synthase
IGB31_RS06295	COG0067	glutamate synthase
IGB31_RS06295	COG0069	glutamate synthase activity
IGB31_RS06295	COG0070	glutamate synthase
IGB31_RS06305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGB31_RS06310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGB31_RS06340	COG0281	malic enzyme
IGB31_RS06350	COG0254	rRNA binding
IGB31_RS06355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IGB31_RS06360	COG0018	arginyl-trna synthetase
IGB31_RS06375	COG0791	NLP P60 protein
IGB31_RS06400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGB31_RS06405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGB31_RS06405	COG2813	Specifically methylates the guanine in position
IGB31_RS06410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGB31_RS06415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGB31_RS06425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IGB31_RS06430	COG2022	thiamine diphosphate biosynthetic process
IGB31_RS06440	COG2363	Small membrane protein
IGB31_RS06445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGB31_RS06455	COG2177	Part of the ABC transporter FtsEX involved in
IGB31_RS06460	COG2884	Cell division ATP-binding protein ftsE
IGB31_RS06465	COG0552	protein localization to endoplasmic reticulum
IGB31_RS06470	COG0612	Peptidase, M16
IGB31_RS06475	COG0612	Peptidase, M16
IGB31_RS06480	COG0742	ribosomal rna small subunit methyltransferase
IGB31_RS06485	COG0612	Peptidase, M16
IGB31_RS06520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IGB31_RS06525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGB31_RS06530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IGB31_RS06535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGB31_RS06545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IGB31_RS06550	COG0129	dihydroxy-acid dehydratase activity
IGB31_RS06560	COG1823	symporter activity
IGB31_RS06575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IGB31_RS06585	COG0789	Transcriptional regulator
IGB31_RS06590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IGB31_RS06595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGB31_RS06600	COG0730	response to heat
IGB31_RS06610	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IGB31_RS06615	COG0494	nUDIX hydrolase
IGB31_RS06625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGB31_RS06630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IGB31_RS06635	COG3204	pilus organization
IGB31_RS06640	COG3204	pilus organization
IGB31_RS06645	COG0179	Fumarylacetoacetate (FAA) hydrolase
IGB31_RS06650	COG0277	FAD linked oxidase domain protein
IGB31_RS06655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGB31_RS06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS06705	COG3829	transcription factor binding
IGB31_RS06715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IGB31_RS06720	COG4208	sulfate ABC transporter
IGB31_RS06730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IGB31_RS06740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGB31_RS06760	COG1177	transmembrane transport
IGB31_RS06765	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGB31_RS06770	COG3842	ATPase activity
IGB31_RS06790	COG0174	glutamine synthetase
IGB31_RS06795	COG0174	glutamine synthetase
IGB31_RS06800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGB31_RS06800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IGB31_RS06805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGB31_RS06815	COG1522	sequence-specific DNA binding
IGB31_RS06830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGB31_RS06830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGB31_RS06835	COG0509	glycine decarboxylation via glycine cleavage system
IGB31_RS06840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGB31_RS06845	COG1178	ABC-type Fe3 transport system permease component
IGB31_RS06855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGB31_RS06865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGB31_RS06870	COG0006	proline dipeptidase activity
IGB31_RS06875	COG3079	Belongs to the UPF0149 family
IGB31_RS06895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IGB31_RS06930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IGB31_RS06945	COG0248	Ppx GppA phosphatase
IGB31_RS06950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IGB31_RS06955	COG0586	Pfam SNARE associated Golgi protein
IGB31_RS06960	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IGB31_RS06965	COG1671	Belongs to the UPF0178 family
IGB31_RS06975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGB31_RS06985	COG1965	Belongs to the frataxin family
IGB31_RS06995	COG0019	diaminopimelate decarboxylase activity
IGB31_RS07000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IGB31_RS07010	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IGB31_RS07015	COG0546	phosphoglycolate phosphatase activity
IGB31_RS07025	COG0004	ammonium transporteR
IGB31_RS07030	COG0347	Belongs to the P(II) protein family
IGB31_RS07045	COG0606	chelatase, subunit chli
IGB31_RS07050	COG4566	intracellular signal transduction
IGB31_RS07055	COG4566	intracellular signal transduction
IGB31_RS07060	COG4191	Histidine kinase
IGB31_RS07065	COG1335	isochorismatase
IGB31_RS07100	COG1335	isochorismatase
IGB31_RS07105	COG0583	DNA-binding transcription factor activity
IGB31_RS07125	COG1335	isochorismatase
IGB31_RS07135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS07145	COG0583	DNA-binding transcription factor activity
IGB31_RS07150	COG5383	Protein conserved in bacteria
IGB31_RS07165	COG0534	Mate efflux family protein
IGB31_RS07180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGB31_RS07185	COG0427	acetyl-CoA hydrolase
IGB31_RS07205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS07220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS07230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS07235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGB31_RS07245	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS07260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGB31_RS07265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGB31_RS07270	COG0747	negative chemotaxis
IGB31_RS07275	COG2003	Belongs to the UPF0758 family
IGB31_RS07280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IGB31_RS07285	COG0756	dUTP diphosphatase activity
IGB31_RS07295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGB31_RS07300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGB31_RS07305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGB31_RS07310	COG0708	Exodeoxyribonuclease III
IGB31_RS07315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IGB31_RS07320	COG1561	YicC-like family, N-terminal region
IGB31_RS07325	COG0194	GDP metabolic process
IGB31_RS07335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGB31_RS07340	COG0174	glutamine synthetase
IGB31_RS07350	COG1758	RNA polymerase activity
IGB31_RS07355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IGB31_RS07380	COG0848	biopolymer transport protein
IGB31_RS07390	COG0583	DNA-binding transcription factor activity
IGB31_RS07395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IGB31_RS07425	COG3161	chorismate lyase activity
IGB31_RS07430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IGB31_RS07450	COG1253	flavin adenine dinucleotide binding
IGB31_RS07455	COG0739	heme binding
IGB31_RS07465	COG0704	Plays a role in the regulation of phosphate uptake
IGB31_RS07470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGB31_RS07475	COG0581	inorganic phosphate transmembrane transporter activity
IGB31_RS07490	COG0477	Major facilitator Superfamily
IGB31_RS07495	COG1607	acyl-coa hydrolase
IGB31_RS07530	COG0583	DNA-binding transcription factor activity
IGB31_RS07535	COG1027	Aspartate ammonia-lyase
IGB31_RS07585	COG0511	ligase activity, forming carbon-carbon bonds
IGB31_RS07585	COG5016	pyruvate
IGB31_RS07590	COG0439	Biotin carboxylase
IGB31_RS07595	COG0583	DNA-binding transcription factor activity
IGB31_RS07610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IGB31_RS07620	COG0210	DNA helicase
IGB31_RS07635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGB31_RS07635	COG4651	solute:proton antiporter activity
IGB31_RS07645	COG1607	acyl-coa hydrolase
IGB31_RS07650	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IGB31_RS07660	COG0523	cobalamin synthesis protein
IGB31_RS07680	COG1469	GTP cyclohydrolase I activity
IGB31_RS07690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGB31_RS07695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGB31_RS07700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGB31_RS07720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IGB31_RS07730	COG0431	NADPH-dependent FMN reductase
IGB31_RS07735	COG0798	PFAM Bile acid sodium symporter
IGB31_RS07740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGB31_RS07745	COG0640	Transcriptional regulator
IGB31_RS07765	COG2194	sulfuric ester hydrolase activity
IGB31_RS07780	COG4644	lycopene metabolic process
IGB31_RS07785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IGB31_RS07800	COG0789	Transcriptional regulator
IGB31_RS07810	COG2608	mercury ion transmembrane transporter activity
IGB31_RS07815	COG2608	mercury ion transmembrane transporter activity
IGB31_RS07820	COG0789	Transcriptional regulator
IGB31_RS07840	COG4584	PFAM Integrase catalytic
IGB31_RS07845	COG1484	DNA-dependent DNA replication
IGB31_RS07925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGB31_RS07955	COG2132	Multicopper oxidase
IGB31_RS08020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGB31_RS08025	COG1349	DNA-binding transcription factor activity
IGB31_RS08030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGB31_RS08035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGB31_RS08040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGB31_RS08045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGB31_RS08050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGB31_RS08055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGB31_RS08060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGB31_RS08070	COG0356	it plays a direct role in the translocation of protons across the membrane
IGB31_RS08075	COG3312	ion transport
IGB31_RS08080	COG1475	DNA binding
IGB31_RS08085	COG1192	Involved in chromosome partitioning
IGB31_RS08090	COG0357	Ribosomal RNA small subunit methyltransferase G
IGB31_RS08095	COG0445	tRNA wobble uridine modification
IGB31_RS08100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IGB31_RS08105	COG0706	membrane insertase activity
IGB31_RS08110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGB31_RS08115	COG0594	ribonuclease P activity
IGB31_RS08120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IGB31_RS08125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IGB31_RS08130	COG0592	DNA-directed DNA polymerase activity
IGB31_RS08135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGB31_RS08140	COG0187	DNA topoisomerase II activity
IGB31_RS08180	COG0477	Major facilitator Superfamily
IGB31_RS08190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IGB31_RS08195	COG0751	glycine-tRNA ligase activity
IGB31_RS08200	COG0752	glycyl-tRNA synthetase alpha subunit
IGB31_RS08205	COG2818	Glycosylase
IGB31_RS08220	COG0569	domain protein
IGB31_RS08225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGB31_RS08230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGB31_RS08235	COG0242	peptide deformylase activity
IGB31_RS08240	COG0758	DNA mediated transformation
IGB31_RS08245	COG0009	L-threonylcarbamoyladenylate synthase
IGB31_RS08260	COG0408	coproporphyrinogen oxidase activity
IGB31_RS08265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGB31_RS08270	COG0659	secondary active sulfate transmembrane transporter activity
IGB31_RS08280	COG3119	arylsulfatase activity
IGB31_RS08285	COG0583	DNA-binding transcription factor activity
IGB31_RS08295	COG0159	tryptophan synthase activity
IGB31_RS08300	COG0133	tryptophan synthase activity
IGB31_RS08315	COG3360	Dodecin
IGB31_RS08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGB31_RS08330	COG1764	response to oxidative stress
IGB31_RS08360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IGB31_RS08365	COG0339	signal peptide processing
IGB31_RS08370	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IGB31_RS08390	COG0659	secondary active sulfate transmembrane transporter activity
IGB31_RS08400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGB31_RS08405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGB31_RS08410	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IGB31_RS08440	COG0109	protoheme IX farnesyltransferase activity
IGB31_RS08455	COG2011	ABC-type metal ion transport system permease component
IGB31_RS08460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGB31_RS08475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGB31_RS08480	COG1121	(ABC) transporter
IGB31_RS08485	COG0735	belongs to the Fur family
IGB31_RS08490	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IGB31_RS08510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IGB31_RS08515	COG3245	cytochrome
IGB31_RS08525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IGB31_RS08540	COG3023	N-Acetylmuramoyl-L-alanine amidase
IGB31_RS08545	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IGB31_RS08550	COG5002	protein histidine kinase activity
IGB31_RS08555	COG2204	response regulator
IGB31_RS08580	COG1301	dicarboxylic acid transport
IGB31_RS08585	COG0700	Nucleoside recognition
IGB31_RS08600	COG1127	ABC transporter
IGB31_RS08605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IGB31_RS08620	COG1283	sodium-dependent phosphate transmembrane transporter activity
IGB31_RS08625	COG0861	Integral membrane protein TerC family
IGB31_RS08630	COG2851	Citrate transporter
IGB31_RS08665	COG0427	acetyl-CoA hydrolase
IGB31_RS08685	COG0583	DNA-binding transcription factor activity
IGB31_RS08690	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS08750	COG3712	iron ion homeostasis
IGB31_RS08770	COG5001	Diguanylate cyclase
IGB31_RS08770	COG3300	MHYT domain
IGB31_RS08775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS08810	COG1289	transmembrane transporter activity
IGB31_RS08820	COG1566	PFAM secretion protein HlyD family protein
IGB31_RS08840	COG0672	)-iron permease
IGB31_RS08855	COG0625	glutathione transferase activity
IGB31_RS08860	COG0165	Argininosuccinate lyase
IGB31_RS08870	COG0181	hydroxymethylbilane synthase activity
IGB31_RS08890	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IGB31_RS08915	COG0488	(ABC) transporter
IGB31_RS08925	COG1280	lysine exporter protein (LysE YggA)
IGB31_RS08955	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS08960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGB31_RS08970	COG2199	diguanylate cyclase activity
IGB31_RS08985	COG2011	ABC-type metal ion transport system permease component
IGB31_RS08990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGB31_RS09015	COG1126	abc transporter atp-binding protein
IGB31_RS09020	COG0765	amino acid transport
IGB31_RS09025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS09030	COG1045	serine acetyltransferase
IGB31_RS09035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IGB31_RS09040	COG2175	clavaminate synthase activity
IGB31_RS09045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGB31_RS09050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IGB31_RS09055	COG4521	taurine ABC transporter
IGB31_RS09065	COG0450	alkyl hydroperoxide reductase
IGB31_RS09070	COG0431	NADPH-dependent FMN reductase
IGB31_RS09075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IGB31_RS09080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGB31_RS09085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGB31_RS09090	COG1116	anion transmembrane transporter activity
IGB31_RS09105	COG2918	glutathione biosynthetic process
IGB31_RS09115	COG2183	response to ionizing radiation
IGB31_RS09130	COG0189	ligase activity
IGB31_RS09135	COG4067	protein conserved in archaea
IGB31_RS09135	COG0189	ligase activity
IGB31_RS09140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IGB31_RS09150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IGB31_RS09155	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IGB31_RS09170	COG0243	molybdopterin cofactor binding
IGB31_RS09175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IGB31_RS09180	COG1652	LysM domain
IGB31_RS09185	COG1011	Hydrolase
IGB31_RS09190	COG0494	nUDIX hydrolase
IGB31_RS09220	COG2957	Belongs to the agmatine deiminase family
IGB31_RS09280	COG4215	(ABC) transporter
IGB31_RS09340	COG3293	Transposase
IGB31_RS09370	COG0463	Glycosyl transferase, family 2
IGB31_RS09385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGB31_RS09395	COG1484	DNA-dependent DNA replication
IGB31_RS09400	COG4584	PFAM Integrase catalytic
IGB31_RS09420	COG3436	PFAM IS66 Orf2 family protein
IGB31_RS09440	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IGB31_RS09455	COG2223	nitrite transmembrane transporter activity
IGB31_RS09465	COG0131	Imidazoleglycerol-phosphate dehydratase
IGB31_RS09470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGB31_RS09480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IGB31_RS09485	COG0107	imidazoleglycerol-phosphate synthase activity
IGB31_RS09495	COG4176	ABC-type proline glycine betaine transport system permease component
IGB31_RS09505	COG1760	l-serine dehydratase
IGB31_RS09515	COG1595	DNA-templated transcription, initiation
IGB31_RS09530	COG2369	cell adhesion
IGB31_RS09540	COG4771	TonB-dependent receptor
IGB31_RS09545	COG0612	Peptidase, M16
IGB31_RS09570	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGB31_RS09575	COG3246	L-lysine catabolic process to acetate
IGB31_RS09615	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGB31_RS09615	COG1902	pentaerythritol trinitrate reductase activity
IGB31_RS09620	COG2181	nitrate reductase activity
IGB31_RS09620	COG0247	lactate metabolic process
IGB31_RS09625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IGB31_RS09645	COG1017	nitric oxide dioxygenase activity
IGB31_RS09645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGB31_RS09665	COG0840	transmembrane signaling receptor activity
IGB31_RS09675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGB31_RS09705	COG1063	alcohol dehydrogenase
IGB31_RS09740	COG0531	amino acid
IGB31_RS09745	COG0204	Acyl-transferase
IGB31_RS09760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGB31_RS09780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IGB31_RS09795	COG0438	transferase activity, transferring glycosyl groups
IGB31_RS09835	COG4774	siderophore transport
IGB31_RS09845	COG1595	DNA-templated transcription, initiation
IGB31_RS09850	COG2176	DNA-directed DNA polymerase activity
IGB31_RS09855	COG0517	IMP dehydrogenase activity
IGB31_RS09855	COG0516	GMP reductase activity
IGB31_RS09865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IGB31_RS09880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IGB31_RS09885	COG3585	molybdate ion transport
IGB31_RS09885	COG2005	Transcriptional regulator
IGB31_RS09890	COG1040	competence protein
IGB31_RS09895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGB31_RS09900	COG0156	8-amino-7-oxononanoate synthase activity
IGB31_RS09925	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS09935	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS09940	COG0583	DNA-binding transcription factor activity
IGB31_RS09945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGB31_RS09960	COG0535	radical SAM domain protein
IGB31_RS09970	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IGB31_RS09975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGB31_RS09985	COG1025	Belongs to the peptidase M16 family
IGB31_RS09990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGB31_RS09995	COG1231	oxidoreductase activity
IGB31_RS10025	COG0358	DNA primase activity
IGB31_RS10030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IGB31_RS10035	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGB31_RS10040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IGB31_RS10045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IGB31_RS10055	COG0617	tRNA 3'-terminal CCA addition
IGB31_RS10060	COG2719	SpoVR family
IGB31_RS10065	COG2718	Belongs to the UPF0229 family
IGB31_RS10070	COG2766	serine protein kinase
IGB31_RS10075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGB31_RS10080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGB31_RS10085	COG2967	ApaG domain
IGB31_RS10090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGB31_RS10095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IGB31_RS10100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGB31_RS10105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IGB31_RS10110	COG3178	'Phosphotransferase
IGB31_RS10115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGB31_RS10120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IGB31_RS10135	COG2197	response regulator
IGB31_RS10140	COG3842	ATPase activity
IGB31_RS10150	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGB31_RS10160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IGB31_RS10165	COG0546	phosphoglycolate phosphatase activity
IGB31_RS10170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGB31_RS10175	COG3240	lipase activity
IGB31_RS10175	COG4625	pathogenesis
IGB31_RS10180	COG0512	Glutamine amidotransferase of anthranilate synthase
IGB31_RS10185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGB31_RS10190	COG0134	indole-3-glycerol-phosphate synthase activity
IGB31_RS10205	COG1765	OsmC-like protein
IGB31_RS10215	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IGB31_RS10220	COG0537	adenosine 5'-monophosphoramidase activity
IGB31_RS10225	COG0300	oxidoreductase activity
IGB31_RS10230	COG1981	membrane
IGB31_RS10235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGB31_RS10240	COG0316	Belongs to the HesB IscA family
IGB31_RS10245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IGB31_RS10250	COG0739	heme binding
IGB31_RS10255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGB31_RS10285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IGB31_RS10285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IGB31_RS10290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IGB31_RS10315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGB31_RS10335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGB31_RS10340	COG0081	regulation of translation
IGB31_RS10345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGB31_RS10350	COG0222	ribosome binding
IGB31_RS10355	COG0085	RNA polymerase activity
IGB31_RS10360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGB31_RS10365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGB31_RS10370	COG0049	tRNA binding
IGB31_RS10375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGB31_RS10380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGB31_RS10385	COG0051	transcription antitermination factor activity, RNA binding
IGB31_RS10390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGB31_RS10395	COG0088	Forms part of the polypeptide exit tunnel
IGB31_RS10400	COG0089	rRNA binding
IGB31_RS10405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGB31_RS10410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IGB31_RS10415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IGB31_RS10420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGB31_RS10425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGB31_RS10430	COG0255	Belongs to the universal ribosomal protein uL29 family
IGB31_RS10435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGB31_RS10440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGB31_RS10445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGB31_RS10450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGB31_RS10455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGB31_RS10460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IGB31_RS10465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IGB31_RS10470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IGB31_RS10475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGB31_RS10480	COG1841	ribosomal large subunit assembly
IGB31_RS10485	COG0200	Binds to the 23S rRNA
IGB31_RS10495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IGB31_RS10500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGB31_RS10505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGB31_RS10510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGB31_RS10515	COG0202	RNA polymerase activity
IGB31_RS10520	COG0203	ribosomal protein L17
IGB31_RS10525	COG0753	catalase activity
IGB31_RS10530	COG2193	ferroxidase activity
IGB31_RS10535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGB31_RS10540	COG2814	Major facilitator Superfamily
IGB31_RS10545	COG0629	single-stranded DNA binding
IGB31_RS10555	COG0437	4 iron, 4 sulfur cluster binding
IGB31_RS10560	COG2864	formate dehydrogenase
IGB31_RS10565	COG3058	Necessary for formate dehydrogenase activity
IGB31_RS10570	COG1921	L-seryl-tRNASec selenium transferase activity
IGB31_RS10575	COG3276	selenocysteine insertion sequence binding
IGB31_RS10585	COG0252	asparaginase activity
IGB31_RS10590	COG1115	amino acid carrier protein
IGB31_RS10615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGB31_RS10630	COG3047	cAMP biosynthetic process
IGB31_RS10645	COG1136	(ABC) transporter
IGB31_RS10660	COG3118	belongs to the thioredoxin family
IGB31_RS10665	COG2264	protein methyltransferase activity
IGB31_RS10675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGB31_RS10680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGB31_RS10680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGB31_RS10695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IGB31_RS10700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGB31_RS10705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IGB31_RS10710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IGB31_RS10720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGB31_RS10730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IGB31_RS10735	COG4206	TonB-dependent receptor
IGB31_RS10740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGB31_RS10745	COG0142	geranyltranstransferase activity
IGB31_RS10750	COG1722	exodeoxyribonuclease VII activity
IGB31_RS10755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGB31_RS10760	COG2819	hydrolase of the alpha beta superfamily
IGB31_RS10785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IGB31_RS10790	COG3228	Belongs to the MtfA family
IGB31_RS10795	COG0586	Pfam SNARE associated Golgi protein
IGB31_RS10800	COG0456	acetyltransferase
IGB31_RS10805	COG4302	ethanolamine ammonia-lyase activity
IGB31_RS10810	COG4303	Ethanolamine ammonia lyase large subunit
IGB31_RS10815	COG0531	amino acid
IGB31_RS10825	COG3284	Transcriptional regulator
IGB31_RS10830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGB31_RS10845	COG0702	epimerase
IGB31_RS10860	COG1063	alcohol dehydrogenase
IGB31_RS10870	COG0022	dehydrogenase e1 component
IGB31_RS10875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGB31_RS10880	COG3199	ATP-NAD kinase
IGB31_RS10885	COG3284	Transcriptional regulator
IGB31_RS10900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IGB31_RS10930	COG0023	Translation Initiation Factor
IGB31_RS10935	COG1166	arginine decarboxylase activity
IGB31_RS10940	COG1943	Transposase
IGB31_RS10945	COG0534	Mate efflux family protein
IGB31_RS10950	COG2373	Large extracellular alpha-helical protein
IGB31_RS10960	COG4953	penicillin-binding protein 1C
IGB31_RS10985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGB31_RS10995	COG2030	dehydratase
IGB31_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS11005	COG0183	Belongs to the thiolase family
IGB31_RS11010	COG2207	Transcriptional regulator
IGB31_RS11040	COG2814	Major facilitator Superfamily
IGB31_RS11050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGB31_RS11060	COG1739	Uncharacterized protein family UPF0029
IGB31_RS11065	COG1309	transcriptional regulator
IGB31_RS11100	COG2995	paraquat-inducible protein a
IGB31_RS11105	COG2995	paraquat-inducible protein a
IGB31_RS11110	COG3008	intermembrane lipid transfer
IGB31_RS11115	COG0268	Binds directly to 16S ribosomal RNA
IGB31_RS11125	COG0196	riboflavin kinase activity
IGB31_RS11130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGB31_RS11135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IGB31_RS11140	COG1047	Peptidyl-prolyl cis-trans
IGB31_RS11145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IGB31_RS11175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS11200	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGB31_RS11240	COG0542	response to heat
IGB31_RS11260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IGB31_RS11280	COG3609	addiction module antidote protein, CC2985 family
IGB31_RS11390	COG1074	ATP-dependent DNA helicase activity
IGB31_RS11430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGB31_RS11565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGB31_RS11575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGB31_RS11625	COG3081	Nucleoid-associated protein
IGB31_RS11640	COG0305	Participates in initiation and elongation during chromosome replication
IGB31_RS11665	COG1252	NADH dehydrogenase
IGB31_RS11685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IGB31_RS11690	COG0237	dephospho-CoA kinase activity
IGB31_RS11715	COG0582	viral genome integration into host DNA
IGB31_RS11760	COG2205	protein histidine kinase activity
IGB31_RS11760	COG0784	Response regulator, receiver
IGB31_RS11830	COG3237	CsbD-like
IGB31_RS11835	COG0765	amino acid transport
IGB31_RS11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS11850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IGB31_RS11860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGB31_RS11875	COG0488	(ABC) transporter
IGB31_RS11880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IGB31_RS11885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGB31_RS11905	COG1067	ATP-dependent peptidase activity
IGB31_RS11915	COG2862	Uncharacterized protein family, UPF0114
IGB31_RS11920	COG0545	Peptidyl-prolyl cis-trans isomerase
IGB31_RS11930	COG2824	Alkylphosphonate utilization operon protein PhnA
IGB31_RS11935	COG0142	geranyltranstransferase activity
IGB31_RS11940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IGB31_RS11945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGB31_RS11950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGB31_RS11955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IGB31_RS11960	COG3045	CreA protein
IGB31_RS11985	COG0456	acetyltransferase
IGB31_RS12010	COG2223	nitrite transmembrane transporter activity
IGB31_RS12030	COG1595	DNA-templated transcription, initiation
IGB31_RS12040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGB31_RS12040	COG2169	Transcriptional regulator
IGB31_RS12045	COG1511	domain protein
IGB31_RS12045	COG3264	Mechanosensitive ion channel
IGB31_RS12070	COG0193	aminoacyl-tRNA hydrolase activity
IGB31_RS12075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IGB31_RS12080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGB31_RS12090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGB31_RS12095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IGB31_RS12105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IGB31_RS12110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGB31_RS12120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IGB31_RS12125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IGB31_RS12145	COG0789	Transcriptional regulator
IGB31_RS12150	COG3272	Protein of unknown function (DUF1722)
IGB31_RS12155	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IGB31_RS12160	COG1090	epimerase
IGB31_RS12165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IGB31_RS12175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IGB31_RS12180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IGB31_RS12195	COG0579	oxidoreductase
IGB31_RS12230	COG2135	peptidase activity
IGB31_RS12240	COG2119	membrane
IGB31_RS12245	COG2813	Specifically methylates the guanine in position
IGB31_RS12250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGB31_RS12255	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS12290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGB31_RS12295	COG2885	chlorophyll binding
IGB31_RS12300	COG0857	belongs to the CobB CobQ family
IGB31_RS12300	COG0280	phosphate acetyltransferase
IGB31_RS12315	COG0386	Belongs to the glutathione peroxidase family
IGB31_RS12330	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IGB31_RS12335	COG0492	ferredoxin-NADP+ reductase activity
IGB31_RS12350	COG3023	N-Acetylmuramoyl-L-alanine amidase
IGB31_RS12360	COG0084	hydrolase, TatD family'
IGB31_RS12365	COG1609	Transcriptional regulator
IGB31_RS12375	COG1105	Belongs to the carbohydrate kinase PfkB family
IGB31_RS12380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGB31_RS12380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IGB31_RS12380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGB31_RS12385	COG3530	Putative quorum-sensing-regulated virulence factor
IGB31_RS12415	COG5002	protein histidine kinase activity
IGB31_RS12425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGB31_RS12475	COG3604	Transcriptional regulator
IGB31_RS12480	COG1017	nitric oxide dioxygenase activity
IGB31_RS12480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGB31_RS12485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IGB31_RS12490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGB31_RS12495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGB31_RS12500	COG1845	cytochrome c oxidase, subunit III
IGB31_RS12505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IGB31_RS12510	COG0109	protoheme IX farnesyltransferase activity
IGB31_RS12515	COG0436	Aminotransferase
IGB31_RS12525	COG0727	PFAM Uncharacterised protein family (UPF0153)
IGB31_RS12530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGB31_RS12545	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IGB31_RS12550	COG0709	Synthesizes selenophosphate from selenide and ATP
IGB31_RS12555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IGB31_RS12560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IGB31_RS12565	COG3639	organic phosphonate transmembrane transporter activity
IGB31_RS12570	COG3639	organic phosphonate transmembrane transporter activity
IGB31_RS12575	COG3781	membrane
IGB31_RS12590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IGB31_RS12595	COG0343	queuine tRNA-ribosyltransferase activity
IGB31_RS12600	COG1862	Preprotein translocase
IGB31_RS12615	COG3134	Outer membrane lipoprotein
IGB31_RS12630	COG1045	serine acetyltransferase
IGB31_RS12640	COG1104	cysteine desulfurase activity
IGB31_RS12650	COG0316	Belongs to the HesB IscA family
IGB31_RS12655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IGB31_RS12660	COG0443	Heat shock 70 kDa protein
IGB31_RS12665	COG0633	Ferredoxin
IGB31_RS12675	COG0105	UTP biosynthetic process
IGB31_RS12680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGB31_RS12695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGB31_RS12700	COG0124	histidyl-tRNA synthetase
IGB31_RS12715	COG1160	GTP binding
IGB31_RS12725	COG0436	Aminotransferase
IGB31_RS12745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IGB31_RS12750	COG4774	siderophore transport
IGB31_RS12755	COG3128	pkhd-type hydroxylase
IGB31_RS12765	COG0019	diaminopimelate decarboxylase activity
IGB31_RS12790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IGB31_RS12805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS12805	COG0723	plastoquinol--plastocyanin reductase activity
IGB31_RS12810	COG4977	sequence-specific DNA binding
IGB31_RS12820	COG4608	Belongs to the ABC transporter superfamily
IGB31_RS12825	COG0444	Belongs to the ABC transporter superfamily
IGB31_RS12830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGB31_RS12835	COG0601	transmembrane transport
IGB31_RS12840	COG0747	negative chemotaxis
IGB31_RS12850	COG0747	negative chemotaxis
IGB31_RS12870	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IGB31_RS12880	COG1113	amino acid transport
IGB31_RS12895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGB31_RS12900	COG0154	amidase activity
IGB31_RS12905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGB31_RS12910	COG1077	Cell shape determining protein MreB Mrl
IGB31_RS12915	COG1792	Involved in formation and maintenance of cell shape
IGB31_RS12925	COG0424	maF-like protein
IGB31_RS12940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGB31_RS12945	COG0312	modulator of DNA gyrase
IGB31_RS12950	COG3028	Belongs to the UPF0307 family
IGB31_RS12955	COG0312	modulator of DNA gyrase
IGB31_RS12985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGB31_RS12990	COG1660	Displays ATPase and GTPase activities
IGB31_RS13000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IGB31_RS13005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IGB31_RS13010	COG1137	ATPase activity
IGB31_RS13015	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IGB31_RS13025	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IGB31_RS13035	COG1127	ABC transporter
IGB31_RS13040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IGB31_RS13045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IGB31_RS13065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGB31_RS13070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IGB31_RS13075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGB31_RS13080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGB31_RS13085	COG2186	Transcriptional regulator
IGB31_RS13090	COG2807	transmembrane transport
IGB31_RS13105	COG2827	Endonuclease containing a URI domain
IGB31_RS13110	COG3081	Nucleoid-associated protein
IGB31_RS13115	COG0776	regulation of translation
IGB31_RS13120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IGB31_RS13125	COG0525	valine-tRNA ligase activity
IGB31_RS13140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGB31_RS13145	COG0795	lipopolysaccharide-transporting ATPase activity
IGB31_RS13150	COG0795	lipopolysaccharide-transporting ATPase activity
IGB31_RS13160	COG1278	Cold shock
IGB31_RS13165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGB31_RS13170	COG1760	l-serine dehydratase
IGB31_RS13175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGB31_RS13175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGB31_RS13180	COG0509	glycine decarboxylation via glycine cleavage system
IGB31_RS13185	COG0786	glutamate:sodium symporter activity
IGB31_RS13205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGB31_RS13210	COG2235	arginine
IGB31_RS13225	COG2832	Protein of unknown function (DUF454)
IGB31_RS13235	COG4771	TonB-dependent receptor
IGB31_RS13235	COG1629	transport
IGB31_RS13285	COG1653	transport
IGB31_RS13290	COG1175	transmembrane transport
IGB31_RS13300	COG3842	ATPase activity
IGB31_RS13310	COG0676	glucose-6-phosphate 1-epimerase activity
IGB31_RS13315	COG1737	Transcriptional regulator
IGB31_RS13330	COG0800	Aldolase
IGB31_RS13335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGB31_RS13340	COG0739	heme binding
IGB31_RS13345	COG1570	exodeoxyribonuclease VII activity
IGB31_RS13350	COG0583	DNA-binding transcription factor activity
IGB31_RS13370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IGB31_RS13370	COG0519	Catalyzes the synthesis of GMP from XMP
IGB31_RS13400	COG0590	tRNA wobble adenosine to inosine editing
IGB31_RS13405	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IGB31_RS13410	COG0047	phosphoribosylformylglycinamidine synthase activity
IGB31_RS13410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGB31_RS13430	COG2816	NAD+ diphosphatase activity
IGB31_RS13455	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IGB31_RS13460	COG0477	Major facilitator Superfamily
IGB31_RS13465	COG4536	flavin adenine dinucleotide binding
IGB31_RS13475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IGB31_RS13480	COG0228	four-way junction DNA binding
IGB31_RS13485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGB31_RS13490	COG0336	Belongs to the RNA methyltransferase TrmD family
IGB31_RS13495	COG0335	large ribosomal subunit rRNA binding
IGB31_RS13500	COG1607	acyl-coa hydrolase
IGB31_RS13505	COG4974	Belongs to the 'phage' integrase family
IGB31_RS13540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGB31_RS13545	COG4681	YaeQ
IGB31_RS13555	COG1902	pentaerythritol trinitrate reductase activity
IGB31_RS13560	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS13565	COG1177	transmembrane transport
IGB31_RS13570	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGB31_RS13575	COG3842	ATPase activity
IGB31_RS13580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IGB31_RS13585	COG2979	Protein of unknown function (DUF533)
IGB31_RS13590	COG0840	transmembrane signaling receptor activity
IGB31_RS13600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IGB31_RS13600	COG0457	Tetratricopeptide repeat
IGB31_RS13615	COG2201	protein-glutamate methylesterase activity
IGB31_RS13620	COG2203	Gaf domain
IGB31_RS13620	COG3706	GGDEF domain
IGB31_RS13620	COG4251	negative regulation of phosphorylation
IGB31_RS13620	COG5001	Diguanylate cyclase
IGB31_RS13630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IGB31_RS13655	COG1073	alpha beta
IGB31_RS13665	COG2885	chlorophyll binding
IGB31_RS13680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IGB31_RS13685	COG0563	adenylate kinase activity
IGB31_RS13720	COG0742	ribosomal rna small subunit methyltransferase
IGB31_RS13735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS13765	COG2937	Belongs to the GPAT DAPAT family
IGB31_RS13780	COG2226	methyltransferase
IGB31_RS13785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGB31_RS13790	COG1215	transferase activity, transferring glycosyl groups
IGB31_RS13795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IGB31_RS13800	COG2166	iron-sulfur cluster assembly
IGB31_RS13805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGB31_RS13810	COG2171	N-acyltransferase activity
IGB31_RS13815	COG1393	Belongs to the ArsC family
IGB31_RS13830	COG0025	NhaP-type Na H and K H
IGB31_RS13835	COG0436	Aminotransferase
IGB31_RS13840	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IGB31_RS13845	COG0024	Methionine aminopeptidase
IGB31_RS13850	COG0052	Belongs to the universal ribosomal protein uS2 family
IGB31_RS13855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGB31_RS13860	COG0528	UMP kinase activity
IGB31_RS13865	COG0233	cytoplasmic translational termination
IGB31_RS13870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGB31_RS13880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IGB31_RS13900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGB31_RS13905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGB31_RS13910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGB31_RS13915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGB31_RS13920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGB31_RS13930	COG0825	malonyl-CoA metabolic process
IGB31_RS13935	COG0037	tRNA processing
IGB31_RS13940	COG0504	CTP synthase activity
IGB31_RS13945	COG0148	phosphopyruvate hydratase activity
IGB31_RS13955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IGB31_RS13965	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IGB31_RS13975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IGB31_RS13980	COG0585	pseudouridine synthase activity
IGB31_RS13985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IGB31_RS13990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGB31_RS14005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IGB31_RS14010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IGB31_RS14015	COG1546	Belongs to the CinA family
IGB31_RS14020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGB31_RS14025	COG2137	regulation of response to DNA damage stimulus
IGB31_RS14045	COG3148	PFAM DTW domain containing protein
IGB31_RS14060	COG0583	DNA-binding transcription factor activity
IGB31_RS14080	COG0037	tRNA processing
IGB31_RS14100	COG1393	Belongs to the ArsC family
IGB31_RS14120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGB31_RS14125	COG5002	protein histidine kinase activity
IGB31_RS14125	COG0784	Response regulator, receiver
IGB31_RS14125	COG2205	protein histidine kinase activity
IGB31_RS14355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGB31_RS14460	COG0004	ammonium transporteR
IGB31_RS14485	COG0840	transmembrane signaling receptor activity
IGB31_RS14495	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IGB31_RS14500	COG0425	Belongs to the sulfur carrier protein TusA family
IGB31_RS14505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGB31_RS14515	COG1132	(ABC) transporter
IGB31_RS14530	COG0521	Mo-molybdopterin cofactor biosynthetic process
IGB31_RS14545	COG1597	lipid kinase activity
IGB31_RS14550	COG2197	response regulator
IGB31_RS14575	COG0741	lytic transglycosylase activity
IGB31_RS14580	COG0488	(ABC) transporter
IGB31_RS14585	COG0589	response to stress
IGB31_RS14595	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGB31_RS14595	COG1024	Enoyl-CoA hydratase
IGB31_RS14600	COG0183	Belongs to the thiolase family
IGB31_RS14630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGB31_RS14645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGB31_RS14655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IGB31_RS14665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGB31_RS14670	COG0584	glycerophosphoryl diester phosphodiesterase
IGB31_RS14680	COG4591	ABC-type transport system involved in lipoprotein release permease component
IGB31_RS14685	COG1136	(ABC) transporter
IGB31_RS14690	COG4591	ABC-type transport system involved in lipoprotein release permease component
IGB31_RS14710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IGB31_RS14710	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IGB31_RS14725	COG2853	Lipoprotein
IGB31_RS14735	COG4566	intracellular signal transduction
IGB31_RS14750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGB31_RS14755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IGB31_RS14785	COG1953	Uracil, thiamine, allantoin
IGB31_RS14795	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS14800	COG0174	glutamine synthetase
IGB31_RS14805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGB31_RS14835	COG0322	excinuclease ABC activity
IGB31_RS14850	COG0582	viral genome integration into host DNA
IGB31_RS14880	COG1846	Transcriptional regulator
IGB31_RS14895	COG1484	DNA-dependent DNA replication
IGB31_RS14900	COG4584	PFAM Integrase catalytic
IGB31_RS14920	COG0583	DNA-binding transcription factor activity
IGB31_RS14935	COG0583	DNA-binding transcription factor activity
IGB31_RS14990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IGB31_RS14995	COG1252	NADH dehydrogenase
IGB31_RS15000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGB31_RS15060	COG2003	Belongs to the UPF0758 family
IGB31_RS15115	COG3311	Transcriptional regulator
IGB31_RS15120	COG1569	PIN domain
IGB31_RS15290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGB31_RS15295	COG0629	single-stranded DNA binding
IGB31_RS15495	COG0840	transmembrane signaling receptor activity
IGB31_RS15515	COG0765	amino acid transport
IGB31_RS15520	COG0765	amino acid transport
IGB31_RS15525	COG1126	abc transporter atp-binding protein
IGB31_RS15540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGB31_RS15560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGB31_RS15565	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS15570	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS15585	COG0366	Alpha amylase catalytic
IGB31_RS15590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGB31_RS15615	COG1640	4-alpha-glucanotransferase
IGB31_RS15620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGB31_RS15625	COG0297	glycogen (starch) synthase activity
IGB31_RS15630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGB31_RS15635	COG5001	Diguanylate cyclase
IGB31_RS15635	COG2203	Gaf domain
IGB31_RS15635	COG3706	GGDEF domain
IGB31_RS15635	COG4251	negative regulation of phosphorylation
IGB31_RS15645	COG4172	Belongs to the ABC transporter superfamily
IGB31_RS15650	COG4239	(ABC) transporter, permease
IGB31_RS15655	COG4174	ABC transporter (Permease)
IGB31_RS15660	COG4166	transmembrane transport
IGB31_RS15665	COG4166	transmembrane transport
IGB31_RS15670	COG1388	LysM domain
IGB31_RS15670	COG0741	lytic transglycosylase activity
IGB31_RS15675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGB31_RS15685	COG0328	RNA-DNA hybrid ribonuclease activity
IGB31_RS15700	COG0431	NADPH-dependent FMN reductase
IGB31_RS15735	COG1007	ATP synthesis coupled electron transport
IGB31_RS15750	COG0713	ATP synthesis coupled electron transport
IGB31_RS15760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGB31_RS15765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGB31_RS15770	COG1034	ATP synthesis coupled electron transport
IGB31_RS15785	COG0649	NAD binding
IGB31_RS15785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGB31_RS15790	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGB31_RS15795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGB31_RS15810	COG0659	secondary active sulfate transmembrane transporter activity
IGB31_RS15815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGB31_RS15830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGB31_RS15835	COG0583	DNA-binding transcription factor activity
IGB31_RS15840	COG1113	amino acid transport
IGB31_RS15845	COG2050	protein possibly involved in aromatic compounds catabolism
IGB31_RS15845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IGB31_RS15860	COG3383	formate dehydrogenase (NAD+) activity
IGB31_RS15870	COG0589	response to stress
IGB31_RS15895	COG1595	DNA-templated transcription, initiation
IGB31_RS15915	COG0010	Belongs to the arginase family
IGB31_RS15925	COG2133	pyrroloquinoline quinone binding
IGB31_RS15930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IGB31_RS15940	COG1238	metal cluster binding
IGB31_RS15950	COG0826	peptidase U32
IGB31_RS15955	COG0628	permease
IGB31_RS15975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGB31_RS15985	COG0183	Belongs to the thiolase family
IGB31_RS15990	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS15995	COG1024	Enoyl-CoA hydratase
IGB31_RS16020	COG1320	monovalent cation:proton antiporter activity
IGB31_RS16025	COG2212	antiporter activity
IGB31_RS16035	COG0651	ATP synthesis coupled electron transport
IGB31_RS16040	COG1006	Multisubunit Na H antiporter MnhC subunit
IGB31_RS16045	COG2111	Na H antiporter
IGB31_RS16045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGB31_RS16060	COG1335	isochorismatase
IGB31_RS16115	COG4178	(ABC) transporter
IGB31_RS16125	COG0730	response to heat
IGB31_RS16130	COG0840	transmembrane signaling receptor activity
IGB31_RS16135	COG0583	DNA-binding transcription factor activity
IGB31_RS16150	COG2186	Transcriptional regulator
IGB31_RS16160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGB31_RS16190	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGB31_RS16195	COG0740	serine-type endopeptidase activity
IGB31_RS16200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGB31_RS16205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGB31_RS16215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGB31_RS16255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IGB31_RS16260	COG2259	Doxx family
IGB31_RS16270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGB31_RS16275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IGB31_RS16280	COG4181	ATPase activity
IGB31_RS16310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IGB31_RS16315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGB31_RS16350	COG0189	ligase activity
IGB31_RS16350	COG4067	protein conserved in archaea
IGB31_RS16355	COG1802	Transcriptional regulator
IGB31_RS16365	COG0372	Belongs to the citrate synthase family
IGB31_RS16395	COG0720	synthase
IGB31_RS16425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IGB31_RS16425	COG0517	IMP dehydrogenase activity
IGB31_RS16425	COG0617	tRNA 3'-terminal CCA addition
IGB31_RS16465	COG4251	negative regulation of phosphorylation
IGB31_RS16505	COG2866	Carboxypeptidase
IGB31_RS16510	COG0656	L-ascorbic acid biosynthetic process
IGB31_RS16545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IGB31_RS16550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IGB31_RS16550	COG0316	Belongs to the HesB IscA family
IGB31_RS16555	COG1999	signal sequence binding
IGB31_RS16605	COG0583	DNA-binding transcription factor activity
IGB31_RS16615	COG0252	asparaginase activity
IGB31_RS16625	COG1129	ABC transporter
IGB31_RS16630	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGB31_RS16635	COG1609	Transcriptional regulator
IGB31_RS16640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGB31_RS16645	COG1869	D-ribose catabolic process
IGB31_RS16665	COG1278	Cold shock
IGB31_RS16675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGB31_RS16680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGB31_RS16685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGB31_RS16690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGB31_RS16695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGB31_RS16700	COG0072	phenylalanine-tRNA ligase activity
IGB31_RS16705	COG0776	regulation of translation
IGB31_RS16735	COG3642	lipopolysaccharide core region biosynthetic process
IGB31_RS16760	COG2186	Transcriptional regulator
IGB31_RS16780	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS16785	COG2066	Belongs to the glutaminase family
IGB31_RS16790	COG0667	Aldo Keto reductase
IGB31_RS16815	COG1024	Enoyl-CoA hydratase
IGB31_RS16820	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS16830	COG0183	Belongs to the thiolase family
IGB31_RS16835	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS16840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IGB31_RS16860	COG0583	DNA-binding transcription factor activity
IGB31_RS16865	COG2814	Major facilitator Superfamily
IGB31_RS16870	COG0625	glutathione transferase activity
IGB31_RS16885	COG2194	sulfuric ester hydrolase activity
IGB31_RS16925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGB31_RS16930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGB31_RS16945	COG2814	Major facilitator Superfamily
IGB31_RS16950	COG0583	DNA-binding transcription factor activity
IGB31_RS16955	COG0531	amino acid
IGB31_RS16960	COG2197	response regulator
IGB31_RS16970	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS16975	COG1053	succinate dehydrogenase
IGB31_RS16985	COG0673	inositol 2-dehydrogenase activity
IGB31_RS17015	COG2391	methyltransferase activity
IGB31_RS17030	COG2186	Transcriptional regulator
IGB31_RS17035	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS17040	COG2721	sulfolactate sulfo-lyase activity
IGB31_RS17045	COG2271	Major facilitator Superfamily
IGB31_RS17050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGB31_RS17055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGB31_RS17060	COG1126	abc transporter atp-binding protein
IGB31_RS17065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS17075	COG4215	(ABC) transporter
IGB31_RS17100	COG0814	amino acid
IGB31_RS17150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IGB31_RS17160	COG0477	Major facilitator Superfamily
IGB31_RS17170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGB31_RS17175	COG3300	MHYT domain
IGB31_RS17175	COG5001	Diguanylate cyclase
IGB31_RS17180	COG1611	Belongs to the LOG family
IGB31_RS17185	COG2855	membrane
IGB31_RS17195	COG2814	Major facilitator Superfamily
IGB31_RS17230	COG2186	Transcriptional regulator
IGB31_RS17235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGB31_RS17245	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS17250	COG2267	carboxylic ester hydrolase activity
IGB31_RS17260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGB31_RS17270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IGB31_RS17285	COG2207	Transcriptional regulator
IGB31_RS17305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IGB31_RS17310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGB31_RS17320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGB31_RS17335	COG0583	DNA-binding transcription factor activity
IGB31_RS17340	COG0477	Major facilitator Superfamily
IGB31_RS17355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS17370	COG4106	trans-aconitate 2-methyltransferase activity
IGB31_RS17375	COG0217	transcriptional regulatory protein
IGB31_RS17380	COG0583	DNA-binding transcription factor activity
IGB31_RS17385	COG0076	glutamate decarboxylase activity
IGB31_RS17395	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IGB31_RS17395	COG1082	Xylose isomerase domain protein TIM barrel
IGB31_RS17400	COG5001	Diguanylate cyclase
IGB31_RS17400	COG3300	MHYT domain
IGB31_RS17450	COG1253	flavin adenine dinucleotide binding
IGB31_RS17460	COG2200	EAL domain
IGB31_RS17475	COG4191	Histidine kinase
IGB31_RS17475	COG0784	Response regulator, receiver
IGB31_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS17540	COG3046	protein related to deoxyribodipyrimidine photolyase
IGB31_RS17555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGB31_RS17570	COG4221	oxidoreductase activity
IGB31_RS17580	COG1366	Belongs to the anti-sigma-factor antagonist family
IGB31_RS17590	COG0693	protein deglycase activity
IGB31_RS17610	COG0028	Belongs to the TPP enzyme family
IGB31_RS17630	COG0673	inositol 2-dehydrogenase activity
IGB31_RS17655	COG1063	alcohol dehydrogenase
IGB31_RS17660	COG4191	Histidine kinase
IGB31_RS17660	COG0784	Response regulator, receiver
IGB31_RS17665	COG0784	Response regulator, receiver
IGB31_RS17665	COG4191	Histidine kinase
IGB31_RS17670	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS17690	COG3920	Histidine kinase
IGB31_RS17745	COG3321	synthase
IGB31_RS17745	COG0604	alcohol dehydrogenase
IGB31_RS17745	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS17765	COG1199	ATP-dependent helicase activity
IGB31_RS17765	COG1199	ATP-dependent helicase activity
IGB31_RS17770	COG4974	Belongs to the 'phage' integrase family
IGB31_RS17775	COG0829	nickel cation binding
IGB31_RS17780	COG0831	urea catabolic process
IGB31_RS17785	COG0832	Belongs to the urease beta subunit family
IGB31_RS17790	COG0804	urea catabolic process
IGB31_RS17795	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IGB31_RS17805	COG0830	nickel cation binding
IGB31_RS17810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IGB31_RS17860	COG0840	transmembrane signaling receptor activity
IGB31_RS17865	COG1968	undecaprenyl-diphosphatase activity
IGB31_RS17890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGB31_RS17900	COG0393	Putative heavy-metal-binding
IGB31_RS17935	COG4221	oxidoreductase activity
IGB31_RS17950	COG1396	sequence-specific DNA binding
IGB31_RS17950	COG1917	Cupin 2, conserved barrel domain protein
IGB31_RS17960	COG3038	cytochrome b561
IGB31_RS17965	COG0753	catalase activity
IGB31_RS17970	COG1595	DNA-templated transcription, initiation
IGB31_RS17980	COG0708	Exodeoxyribonuclease III
IGB31_RS17990	COG0729	surface antigen
IGB31_RS18030	COG2366	antibiotic biosynthetic process
IGB31_RS18035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGB31_RS18045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGB31_RS18050	COG0215	cysteine-tRNA ligase activity
IGB31_RS18060	COG0745	RESPONSE REGULATOR receiver
IGB31_RS18070	COG0113	porphobilinogen synthase activity
IGB31_RS18085	COG0307	riboflavin synthase, alpha
IGB31_RS18100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IGB31_RS18110	COG1984	allophanate hydrolase subunit 2
IGB31_RS18130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IGB31_RS18140	COG0581	inorganic phosphate transmembrane transporter activity
IGB31_RS18145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGB31_RS18170	COG0784	Response regulator, receiver
IGB31_RS18170	COG2205	protein histidine kinase activity
IGB31_RS18190	COG1131	(ABC) transporter
IGB31_RS18270	COG0784	Response regulator, receiver
IGB31_RS18270	COG2205	protein histidine kinase activity
IGB31_RS18270	COG5002	protein histidine kinase activity
IGB31_RS18280	COG1305	Transglutaminase-like
IGB31_RS18290	COG2308	Evidence 4 Homologs of previously reported genes of
IGB31_RS18320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS18335	COG3265	gluconokinase activity
IGB31_RS18340	COG1609	Transcriptional regulator
IGB31_RS18350	COG2205	protein histidine kinase activity
IGB31_RS18350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS18355	COG2197	response regulator
IGB31_RS18430	COG1609	Transcriptional regulator
IGB31_RS18440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGB31_RS18445	COG2271	Major facilitator Superfamily
IGB31_RS18455	COG2356	endonuclease I
IGB31_RS18460	COG0667	Aldo Keto reductase
IGB31_RS18465	COG2814	Major facilitator Superfamily
IGB31_RS18470	COG0583	DNA-binding transcription factor activity
IGB31_RS18485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGB31_RS18495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGB31_RS18525	COG4206	TonB-dependent receptor
IGB31_RS18550	COG1595	DNA-templated transcription, initiation
IGB31_RS18555	COG3712	iron ion homeostasis
IGB31_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS18590	COG0243	molybdopterin cofactor binding
IGB31_RS18595	COG0668	transmembrane transport
IGB31_RS18610	COG0302	gtp cyclohydrolase
IGB31_RS18620	COG0861	Integral membrane protein TerC family
IGB31_RS18650	COG1230	cation diffusion facilitator family transporter
IGB31_RS18665	COG0583	DNA-binding transcription factor activity
IGB31_RS18670	COG2197	response regulator
IGB31_RS18680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IGB31_RS18710	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS18715	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS18720	COG3162	membrane
IGB31_RS18725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGB31_RS18730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGB31_RS18735	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS18740	COG0531	amino acid
IGB31_RS18755	COG2072	flavoprotein involved in K transport
IGB31_RS18790	COG2409	Drug exporters of the RND superfamily
IGB31_RS18805	COG2508	Transcriptional regulator
IGB31_RS18815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS18905	COG5290	Psort location Cytoplasmic, score
IGB31_RS18950	COG1484	DNA-dependent DNA replication
IGB31_RS18955	COG4584	PFAM Integrase catalytic
IGB31_RS19005	COG1196	nuclear chromosome segregation
IGB31_RS19010	COG1074	ATP-dependent DNA helicase activity
IGB31_RS19035	COG0497	DNA recombination
IGB31_RS19055	COG4584	PFAM Integrase catalytic
IGB31_RS19060	COG1484	DNA-dependent DNA replication
IGB31_RS19075	COG2129	metallophosphoesterase
IGB31_RS19095	COG2080	2 iron, 2 sulfur cluster binding
IGB31_RS19100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IGB31_RS19105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGB31_RS19135	COG3568	Endonuclease Exonuclease Phosphatase
IGB31_RS19140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGB31_RS19145	COG0392	lysyltransferase activity
IGB31_RS19195	COG2264	protein methyltransferase activity
IGB31_RS19210	COG3729	General stress protein
IGB31_RS19220	COG0667	Aldo Keto reductase
IGB31_RS19225	COG2837	iron assimilation
IGB31_RS19240	COG1285	pathogenesis
IGB31_RS19270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGB31_RS19275	COG0402	S-adenosylhomocysteine deaminase activity
IGB31_RS19285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IGB31_RS19290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IGB31_RS19305	COG1929	Belongs to the glycerate kinase type-1 family
IGB31_RS19310	COG3835	regulator
IGB31_RS19315	COG2271	Major facilitator Superfamily
IGB31_RS19320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGB31_RS19370	COG0583	DNA-binding transcription factor activity
IGB31_RS19375	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS19390	COG0174	glutamine synthetase
IGB31_RS19400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS19405	COG1760	l-serine dehydratase
IGB31_RS19410	COG0583	DNA-binding transcription factor activity
IGB31_RS19435	COG2990	Protein conserved in bacteria
IGB31_RS19440	COG1215	transferase activity, transferring glycosyl groups
IGB31_RS19485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IGB31_RS19515	COG1396	sequence-specific DNA binding
IGB31_RS19520	COG2031	fatty acid transporter
IGB31_RS19530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IGB31_RS19540	COG0656	L-ascorbic acid biosynthetic process
IGB31_RS19545	COG0587	DNA-directed DNA polymerase activity
IGB31_RS19560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGB31_RS19575	COG1414	Transcriptional regulator
IGB31_RS19580	COG0154	amidase activity
IGB31_RS19590	COG1473	amidohydrolase
IGB31_RS19595	COG4774	siderophore transport
IGB31_RS19615	COG0028	Belongs to the TPP enzyme family
IGB31_RS19640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGB31_RS19645	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS19690	COG3436	PFAM IS66 Orf2 family protein
IGB31_RS19740	COG3436	PFAM IS66 Orf2 family protein
IGB31_RS19785	COG3209	COG3209 Rhs family protein
IGB31_RS19910	COG1595	DNA-templated transcription, initiation
IGB31_RS19915	COG3712	iron ion homeostasis
IGB31_RS19970	COG3052	prosthetic group binding
IGB31_RS19990	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS20005	COG2384	SAM-dependent methyltransferase
IGB31_RS20015	COG0826	peptidase U32
IGB31_RS20020	COG2204	response regulator
IGB31_RS20055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGB31_RS20095	COG1309	transcriptional regulator
IGB31_RS20105	COG3257	ureidoglycine aminohydrolase activity
IGB31_RS20115	COG0583	DNA-binding transcription factor activity
IGB31_RS20120	COG0405	Gamma-glutamyltransferase
IGB31_RS20135	COG0789	Transcriptional regulator
IGB31_RS20145	COG1285	pathogenesis
IGB31_RS20155	COG0348	domain, Protein
IGB31_RS20160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS20170	COG2814	Major facilitator Superfamily
IGB31_RS20175	COG1566	PFAM secretion protein HlyD family protein
IGB31_RS20180	COG1846	Transcriptional regulator
IGB31_RS20185	COG4566	intracellular signal transduction
IGB31_RS20195	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS20200	COG1960	acyl-CoA dehydrogenase activity
IGB31_RS20210	COG2056	Na+-H+ antiporter family
IGB31_RS20215	COG0840	transmembrane signaling receptor activity
IGB31_RS20225	COG4176	ABC-type proline glycine betaine transport system permease component
IGB31_RS20230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGB31_RS20240	COG2205	protein histidine kinase activity
IGB31_RS20245	COG0745	RESPONSE REGULATOR receiver
IGB31_RS20250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS20260	COG0776	regulation of translation
IGB31_RS20265	COG0746	molybdenum cofactor guanylyltransferase activity
IGB31_RS20275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IGB31_RS20280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGB31_RS20290	COG4174	ABC transporter (Permease)
IGB31_RS20295	COG4239	(ABC) transporter, permease
IGB31_RS20300	COG3829	transcription factor binding
IGB31_RS20300	COG3290	protein histidine kinase activity
IGB31_RS20305	COG2610	gluconate transmembrane transporter activity
IGB31_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS20315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGB31_RS20335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGB31_RS20350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGB31_RS20385	COG5002	protein histidine kinase activity
IGB31_RS20390	COG0596	Alpha beta hydrolase
IGB31_RS20410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IGB31_RS20410	COG0456	acetyltransferase
IGB31_RS20420	COG0488	(ABC) transporter
IGB31_RS20435	COG0625	glutathione transferase activity
IGB31_RS20455	COG0019	diaminopimelate decarboxylase activity
IGB31_RS20470	COG0583	DNA-binding transcription factor activity
IGB31_RS20525	COG0640	Transcriptional regulator
IGB31_RS20530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IGB31_RS20535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGB31_RS20540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGB31_RS20545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGB31_RS20555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS20585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS20590	COG0697	spore germination
IGB31_RS20595	COG0583	DNA-binding transcription factor activity
IGB31_RS20600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGB31_RS20605	COG1132	(ABC) transporter
IGB31_RS20610	COG1414	Transcriptional regulator
IGB31_RS20615	COG1053	succinate dehydrogenase
IGB31_RS20620	COG1944	ATP diphosphatase activity
IGB31_RS20660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IGB31_RS20670	COG4991	sh3 domain protein
IGB31_RS20680	COG0346	lactoylglutathione lyase activity
IGB31_RS20695	COG0596	Alpha beta hydrolase
IGB31_RS20700	COG0210	DNA helicase
IGB31_RS20730	COG1280	lysine exporter protein (LysE YggA)
IGB31_RS20735	COG2814	Major facilitator Superfamily
IGB31_RS20740	COG0583	DNA-binding transcription factor activity
IGB31_RS20775	COG4774	siderophore transport
IGB31_RS20780	COG3712	iron ion homeostasis
IGB31_RS20785	COG1595	DNA-templated transcription, initiation
IGB31_RS20810	COG3485	protocatechuate 3,4-dioxygenase
IGB31_RS20815	COG4829	muconolactone delta-isomerase
IGB31_RS20820	COG4948	Mandelate Racemase Muconate Lactonizing
IGB31_RS20835	COG0577	efflux transmembrane transporter activity
IGB31_RS20865	COG0768	penicillin binding
IGB31_RS20880	COG2186	Transcriptional regulator
IGB31_RS20885	COG0277	FAD linked oxidase domain protein
IGB31_RS20890	COG0277	FAD linked oxidase domain protein
IGB31_RS20895	COG0247	lactate metabolic process
IGB31_RS20900	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IGB31_RS20915	COG2807	transmembrane transport
IGB31_RS20920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGB31_RS20930	COG0183	Belongs to the thiolase family
IGB31_RS20935	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGB31_RS20945	COG2198	Histidine kinase
IGB31_RS20945	COG2205	protein histidine kinase activity
IGB31_RS20945	COG0784	Response regulator, receiver
IGB31_RS20945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS20950	COG3437	response regulator, receiver
IGB31_RS20950	COG4999	Histidine kinase
IGB31_RS20950	COG2205	protein histidine kinase activity
IGB31_RS20950	COG3850	Histidine kinase
IGB31_RS20960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IGB31_RS20965	COG5002	protein histidine kinase activity
IGB31_RS20965	COG0784	Response regulator, receiver
IGB31_RS20965	COG2198	Histidine kinase
IGB31_RS21005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGB31_RS21040	COG1686	Belongs to the peptidase S11 family
IGB31_RS21075	COG1121	(ABC) transporter
IGB31_RS21115	COG0583	DNA-binding transcription factor activity
IGB31_RS21120	COG0657	acetylesterase activity
IGB31_RS21135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGB31_RS21145	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGB31_RS21150	COG1177	transmembrane transport
IGB31_RS21155	COG3842	ATPase activity
IGB31_RS21165	COG0861	Integral membrane protein TerC family
IGB31_RS21180	COG1104	cysteine desulfurase activity
IGB31_RS21190	COG0583	DNA-binding transcription factor activity
IGB31_RS21205	COG2814	Major facilitator Superfamily
IGB31_RS21215	COG1064	alcohol dehydrogenase
IGB31_RS21220	COG2207	Transcriptional regulator
IGB31_RS21235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGB31_RS21245	COG4774	siderophore transport
IGB31_RS21260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGB31_RS21265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGB31_RS21285	COG0477	Major facilitator Superfamily
IGB31_RS21305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IGB31_RS21310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGB31_RS21325	COG0417	DNA replication proofreading
IGB31_RS21330	COG4772	TonB-dependent receptor
IGB31_RS21340	COG2199	diguanylate cyclase activity
IGB31_RS21340	COG2200	EAL domain
IGB31_RS21340	COG2203	Gaf domain
IGB31_RS21365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS21380	COG1253	flavin adenine dinucleotide binding
IGB31_RS21390	COG0583	DNA-binding transcription factor activity
IGB31_RS21395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IGB31_RS21400	COG3132	Protein of unknown function, DUF480
IGB31_RS21410	COG3634	alkyl hydroperoxide reductase activity
IGB31_RS21430	COG3258	Cytochrome c
IGB31_RS21435	COG2863	cytochrome
IGB31_RS21470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IGB31_RS21480	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IGB31_RS21485	COG0745	RESPONSE REGULATOR receiver
IGB31_RS21490	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IGB31_RS21495	COG4191	Histidine kinase
IGB31_RS21495	COG0784	Response regulator, receiver
IGB31_RS21505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IGB31_RS21510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGB31_RS21515	COG2271	Major facilitator Superfamily
IGB31_RS21520	COG2207	Transcriptional regulator
IGB31_RS21535	COG2814	Major facilitator Superfamily
IGB31_RS21560	COG2197	response regulator
IGB31_RS21575	COG2259	Doxx family
IGB31_RS21585	COG1064	alcohol dehydrogenase
IGB31_RS21610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGB31_RS21615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS21650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGB31_RS21660	COG2135	peptidase activity
IGB31_RS21675	COG0616	signal peptide processing
IGB31_RS21725	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS21730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGB31_RS21760	COG0471	metal ion transport
IGB31_RS21760	COG0490	domain, Protein
IGB31_RS21765	COG2199	diguanylate cyclase activity
IGB31_RS21800	COG0840	transmembrane signaling receptor activity
IGB31_RS21810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IGB31_RS21815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGB31_RS21855	COG4584	PFAM Integrase catalytic
IGB31_RS21860	COG1484	DNA-dependent DNA replication
IGB31_RS21895	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS21895	COG0604	alcohol dehydrogenase
IGB31_RS21895	COG3321	synthase
IGB31_RS21920	COG2233	PERMEase
IGB31_RS21940	COG2920	part of a sulfur-relay system
IGB31_RS21945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGB31_RS21950	COG0435	Glutathione S-transferase
IGB31_RS21955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGB31_RS21955	COG1648	precorrin-2 dehydrogenase activity
IGB31_RS21960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGB31_RS21965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGB31_RS21970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGB31_RS21975	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IGB31_RS21980	COG1674	ftsk spoiiie
IGB31_RS21985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IGB31_RS21990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IGB31_RS21995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGB31_RS22000	COG0542	response to heat
IGB31_RS22005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IGB31_RS22010	COG1278	Cold shock
IGB31_RS22030	COG0482	sulfurtransferase activity
IGB31_RS22035	COG2915	High frequency lysogenization protein hflD homolog
IGB31_RS22045	COG2850	peptidyl-arginine hydroxylation
IGB31_RS22050	COG2153	protein acetylation
IGB31_RS22060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IGB31_RS22070	COG0583	DNA-binding transcription factor activity
IGB31_RS22075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS22085	COG2816	NAD+ diphosphatase activity
IGB31_RS22090	COG1024	Enoyl-CoA hydratase
IGB31_RS22100	COG1234	tRNA 3'-trailer cleavage
IGB31_RS22110	COG1953	Uracil, thiamine, allantoin
IGB31_RS22120	COG0493	'glutamate synthase
IGB31_RS22130	COG1309	transcriptional regulator
IGB31_RS22140	COG3387	PFAM Glycoside hydrolase 15-related
IGB31_RS22145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IGB31_RS22150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IGB31_RS22160	COG0583	DNA-binding transcription factor activity
IGB31_RS22180	COG0745	RESPONSE REGULATOR receiver
IGB31_RS22185	COG2205	protein histidine kinase activity
IGB31_RS22190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IGB31_RS22200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IGB31_RS22210	COG0628	permease
IGB31_RS22235	COG2062	phosphohistidine phosphatase, SixA
IGB31_RS22245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGB31_RS22260	COG3850	Histidine kinase
IGB31_RS22260	COG2205	protein histidine kinase activity
IGB31_RS22260	COG3437	response regulator, receiver
IGB31_RS22260	COG4999	Histidine kinase
IGB31_RS22265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGB31_RS22280	COG1741	Belongs to the pirin family
IGB31_RS22290	COG0326	Molecular chaperone. Has ATPase activity
IGB31_RS22325	COG0045	succinate-CoA ligase (ADP-forming) activity
IGB31_RS22330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGB31_RS22350	COG1053	succinate dehydrogenase
IGB31_RS22355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IGB31_RS22360	COG2009	succinate dehydrogenase
IGB31_RS22375	COG1215	transferase activity, transferring glycosyl groups
IGB31_RS22405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGB31_RS22410	COG2885	chlorophyll binding
IGB31_RS22440	COG0477	Major facilitator Superfamily
IGB31_RS22455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS22460	COG1136	(ABC) transporter
IGB31_RS22460	COG0577	efflux transmembrane transporter activity
IGB31_RS22485	COG0515	serine threonine protein kinase
IGB31_RS22485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IGB31_RS22505	COG0657	acetylesterase activity
IGB31_RS22535	COG0642	Histidine kinase
IGB31_RS22575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IGB31_RS22575	COG3608	succinylglutamate desuccinylase aspartoacylase
IGB31_RS22600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGB31_RS22645	COG3123	guanosine phosphorylase activity
IGB31_RS22655	COG3278	Belongs to the heme-copper respiratory oxidase family
IGB31_RS22670	COG2010	Cytochrome c
IGB31_RS22675	COG3278	Belongs to the heme-copper respiratory oxidase family
IGB31_RS22690	COG2010	Cytochrome c
IGB31_RS22695	COG0348	domain, Protein
IGB31_RS22705	COG2217	Heavy metal translocating P-type atpase
IGB31_RS22725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGB31_RS22730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGB31_RS22735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IGB31_RS22740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IGB31_RS22745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IGB31_RS22760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGB31_RS22765	COG3115	cell septum assembly
IGB31_RS22795	COG0402	S-adenosylhomocysteine deaminase activity
IGB31_RS22805	COG2252	PERMEase
IGB31_RS22825	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IGB31_RS22835	COG2233	PERMEase
IGB31_RS22850	COG2354	Protein conserved in bacteria
IGB31_RS22865	COG3960	tartronate-semialdehyde synthase activity
IGB31_RS22870	COG3622	Belongs to the hyi family
IGB31_RS22875	COG2084	Dehydrogenase
IGB31_RS22885	COG0469	pyruvate kinase activity
IGB31_RS22895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGB31_RS22905	COG0668	transmembrane transport
IGB31_RS22910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IGB31_RS22910	COG0116	Belongs to the methyltransferase superfamily
IGB31_RS22920	COG1522	sequence-specific DNA binding
IGB31_RS22925	COG1953	Uracil, thiamine, allantoin
IGB31_RS22980	COG1138	Cytochrome C-type biogenesis protein
IGB31_RS22985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IGB31_RS23005	COG4133	protoheme IX ABC transporter activity
IGB31_RS23015	COG2257	FlhB HrpN YscU SpaS Family
IGB31_RS23035	COG0835	chemotaxis
IGB31_RS23045	COG1192	Involved in chromosome partitioning
IGB31_RS23050	COG1360	Flagellar Motor Protein
IGB31_RS23055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IGB31_RS23060	COG2201	protein-glutamate methylesterase activity
IGB31_RS23065	COG0643	Histidine kinase
IGB31_RS23065	COG2198	Histidine kinase
IGB31_RS23065	COG0784	Response regulator, receiver
IGB31_RS23070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IGB31_RS23095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IGB31_RS23115	COG1987	bacterial-type flagellum assembly
IGB31_RS23155	COG0745	RESPONSE REGULATOR receiver
IGB31_RS23165	COG2882	bacterial-type flagellum organization
IGB31_RS23190	COG1677	Flagellar hook-basal body complex protein FliE
IGB31_RS23220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IGB31_RS23235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGB31_RS23255	COG1706	bacterial-type flagellum-dependent cell motility
IGB31_RS23260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IGB31_RS23270	COG4787	bacterial-type flagellum-dependent cell motility
IGB31_RS23285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IGB31_RS23295	COG1815	bacterial-type flagellum-dependent cell motility
IGB31_RS23300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IGB31_RS23305	COG0784	Response regulator, receiver
IGB31_RS23305	COG0835	chemotaxis
IGB31_RS23325	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IGB31_RS23330	COG0477	Major facilitator Superfamily
IGB31_RS23335	COG1522	sequence-specific DNA binding
IGB31_RS23340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGB31_RS23345	COG0022	dehydrogenase e1 component
IGB31_RS23355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGB31_RS23360	COG3706	GGDEF domain
IGB31_RS23380	COG2239	Acts as a magnesium transporter
IGB31_RS23410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IGB31_RS23415	COG0527	aspartate kinase activity
IGB31_RS23420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGB31_RS23430	COG2988	succinylglutamate desuccinylase activity
IGB31_RS23440	COG3724	N-succinylarginine dihydrolase activity
IGB31_RS23445	COG1012	belongs to the aldehyde dehydrogenase family
IGB31_RS23460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGB31_RS23480	COG4215	(ABC) transporter
IGB31_RS23485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGB31_RS23490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGB31_RS23510	COG2154	pterin-4-alpha-carbinolamine dehydratase
IGB31_RS23520	COG0277	FAD linked oxidase domain protein
IGB31_RS23520	COG0247	lactate metabolic process
IGB31_RS23530	COG1113	amino acid transport
IGB31_RS23540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IGB31_RS23545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IGB31_RS23550	COG0009	L-threonylcarbamoyladenylate synthase
IGB31_RS23555	COG0613	PHP domain protein
IGB31_RS23560	COG2917	probably involved in intracellular septation
IGB31_RS23565	COG2350	Protein conserved in bacteria
IGB31_RS23570	COG0745	RESPONSE REGULATOR receiver
IGB31_RS23585	COG0778	Nitroreductase
IGB31_RS23590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IGB31_RS23615	COG1752	Esterase of the alpha-beta hydrolase superfamily
IGB31_RS23635	COG2832	Protein of unknown function (DUF454)
IGB31_RS23650	COG0840	transmembrane signaling receptor activity
IGB31_RS23665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGB31_RS23685	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGB31_RS23695	COG0513	Belongs to the DEAD box helicase family
IGB31_RS23700	COG0668	transmembrane transport
IGB31_RS23715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGB31_RS23730	COG2267	carboxylic ester hydrolase activity
IGB31_RS23740	COG1132	(ABC) transporter
IGB31_RS23750	COG2188	Transcriptional regulator
IGB31_RS23760	COG1643	Atp-dependent helicase
IGB31_RS23770	COG0174	glutamine synthetase
IGB31_RS23775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS23780	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS23785	COG0318	PFAM AMP-dependent synthetase and ligase
IGB31_RS23790	COG2267	carboxylic ester hydrolase activity
IGB31_RS23795	COG2030	dehydratase
IGB31_RS23815	COG0242	peptide deformylase activity
IGB31_RS23820	COG1295	ribonuclease BN
IGB31_RS23850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IGB31_RS23880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGB31_RS23900	COG1984	allophanate hydrolase subunit 2
IGB31_RS23905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IGB31_RS23910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IGB31_RS23915	COG2814	Major facilitator Superfamily
IGB31_RS23920	COG0583	DNA-binding transcription factor activity
IGB31_RS23930	COG0121	glutamine amidotransferase
IGB31_RS23985	COG2983	Belongs to the UPF0260 family
IGB31_RS24000	COG3100	YcgL domain-containing protein
IGB31_RS24010	COG2194	sulfuric ester hydrolase activity
IGB31_RS24020	COG0626	cystathionine gamma-synthase activity
IGB31_RS24025	COG1522	sequence-specific DNA binding
IGB31_RS24035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGB31_RS24040	COG3781	membrane
IGB31_RS24045	COG0521	Mo-molybdopterin cofactor biosynthetic process
IGB31_RS24050	COG0583	DNA-binding transcription factor activity
IGB31_RS24060	COG0531	amino acid
IGB31_RS24065	COG3938	Belongs to the proline racemase family
IGB31_RS24070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGB31_RS24080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS24085	COG1902	pentaerythritol trinitrate reductase activity
IGB31_RS24090	COG0640	Transcriptional regulator
IGB31_RS24095	COG0579	oxidoreductase
IGB31_RS24155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGB31_RS24225	COG2433	Pfam Transposase IS66
IGB31_RS24230	COG0784	Response regulator, receiver
IGB31_RS24230	COG4191	Histidine kinase
IGB31_RS24240	COG0745	RESPONSE REGULATOR receiver
IGB31_RS24245	COG2205	protein histidine kinase activity
IGB31_RS24245	COG2198	Histidine kinase
IGB31_RS24245	COG0784	Response regulator, receiver
IGB31_RS24335	COG3436	PFAM IS66 Orf2 family protein
IGB31_RS24355	COG0745	RESPONSE REGULATOR receiver
IGB31_RS24365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IGB31_RS24370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGB31_RS24380	COG3284	Transcriptional regulator
IGB31_RS24395	COG1177	transmembrane transport
IGB31_RS24400	COG3842	ATPase activity
IGB31_RS24410	COG2223	nitrite transmembrane transporter activity
IGB31_RS24420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGB31_RS24430	COG4584	PFAM Integrase catalytic
IGB31_RS24435	COG1484	DNA-dependent DNA replication
IGB31_RS24440	COG0840	transmembrane signaling receptor activity
IGB31_RS24455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IGB31_RS24460	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IGB31_RS24465	COG0251	oxidation-reduction process
IGB31_RS24470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS24475	COG1414	Transcriptional regulator
IGB31_RS24480	COG0697	spore germination
IGB31_RS24520	COG1476	TRANSCRIPTIONal
IGB31_RS24535	COG3039	Transposase
IGB31_RS24565	COG3039	Transposase
IGB31_RS24575	COG4993	Dehydrogenase
IGB31_RS24580	COG3039	Transposase
IGB31_RS24650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IGB31_RS24655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGB31_RS24660	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IGB31_RS24665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGB31_RS24675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IGB31_RS24685	COG0425	Belongs to the sulfur carrier protein TusA family
IGB31_RS24695	COG0519	Catalyzes the synthesis of GMP from XMP
IGB31_RS24720	COG1368	sulfuric ester hydrolase activity
IGB31_RS24750	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IGB31_RS24755	COG2814	Major facilitator Superfamily
IGB31_RS24760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGB31_RS24790	COG2840	Smr protein MutS2
IGB31_RS24795	COG0302	gtp cyclohydrolase
IGB31_RS24805	COG0625	glutathione transferase activity
IGB31_RS24810	COG3135	benzoate transporter
IGB31_RS24820	COG0840	transmembrane signaling receptor activity
IGB31_RS24825	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS24830	COG2130	NADP-dependent
IGB31_RS24835	COG1215	transferase activity, transferring glycosyl groups
IGB31_RS24845	COG0284	orotidine-5'-phosphate decarboxylase activity
IGB31_RS24855	COG1555	photosystem II stabilization
IGB31_RS24865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IGB31_RS24880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGB31_RS24895	COG0438	transferase activity, transferring glycosyl groups
IGB31_RS24905	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IGB31_RS24915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGB31_RS24940	COG0438	transferase activity, transferring glycosyl groups
IGB31_RS24940	COG1216	Glycosyl transferase, family 2
IGB31_RS24975	COG1091	dTDP-4-dehydrorhamnose reductase activity
IGB31_RS24990	COG0517	IMP dehydrogenase activity
IGB31_RS24990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IGB31_RS25000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGB31_RS25030	COG0438	transferase activity, transferring glycosyl groups
IGB31_RS25035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGB31_RS25045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IGB31_RS25055	COG0776	regulation of translation
IGB31_RS25070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IGB31_RS25075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGB31_RS25085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IGB31_RS25095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IGB31_RS25100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGB31_RS25105	COG0546	phosphoglycolate phosphatase activity
IGB31_RS25110	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS25120	COG5002	protein histidine kinase activity
IGB31_RS25120	COG5001	Diguanylate cyclase
IGB31_RS25135	COG1054	Belongs to the UPF0176 family
IGB31_RS25140	COG0271	Belongs to the BolA IbaG family
IGB31_RS25150	COG0114	fumarate hydratase activity
IGB31_RS25155	COG0697	spore germination
IGB31_RS25160	COG2326	polyphosphate kinase activity
IGB31_RS25165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGB31_RS25165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IGB31_RS25170	COG0367	asparagine synthase
IGB31_RS25175	COG0189	ligase activity
IGB31_RS25175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGB31_RS25180	COG1363	Peptidase, m42
IGB31_RS25190	COG3089	Belongs to the UPF0270 family
IGB31_RS25195	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IGB31_RS25210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IGB31_RS25215	COG3162	membrane
IGB31_RS25220	COG2113	Glycine betaine
IGB31_RS25240	COG2853	Lipoprotein
IGB31_RS25250	COG1560	Kdo2-lipid A biosynthetic process
IGB31_RS25255	COG0850	regulation of cytokinetic process
IGB31_RS25260	COG2894	cell division
IGB31_RS25265	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IGB31_RS25270	COG0564	pseudouridine synthase activity
IGB31_RS25275	COG1362	aminopeptidase activity
IGB31_RS25285	COG0668	transmembrane transport
IGB31_RS25305	COG0395	ABC-type sugar transport system, permease component
IGB31_RS25345	COG2184	nucleotidyltransferase activity
IGB31_RS25355	COG3339	Conserved Protein
IGB31_RS25360	COG0545	Peptidyl-prolyl cis-trans isomerase
IGB31_RS25365	COG0583	DNA-binding transcription factor activity
IGB31_RS25370	COG2169	Transcriptional regulator
IGB31_RS25375	COG2271	Major facilitator Superfamily
IGB31_RS25385	COG1028	Short-chain dehydrogenase reductase Sdr
IGB31_RS25390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGB31_RS25395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGB31_RS25395	COG2146	nitrite reductase [NAD(P)H] activity
IGB31_RS25400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGB31_RS25400	COG2146	nitrite reductase [NAD(P)H] activity
IGB31_RS25405	COG0243	molybdopterin cofactor binding
IGB31_RS25410	COG0024	Methionine aminopeptidase
IGB31_RS25435	COG2974	May be involved in recombination
IGB31_RS25440	COG2076	Multidrug Resistance protein
IGB31_RS25445	COG0477	Major facilitator Superfamily
IGB31_RS25455	COG2814	Major facilitator Superfamily
IGB31_RS25460	COG2188	Transcriptional regulator
IGB31_RS25465	COG2205	protein histidine kinase activity
IGB31_RS25495	COG0583	DNA-binding transcription factor activity
IGB31_RS25510	COG1484	DNA-dependent DNA replication
IGB31_RS25515	COG4584	PFAM Integrase catalytic
IGB31_RS25535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IGB31_RS25545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGB31_RS25555	COG1492	cobalamin metabolic process
IGB31_RS25565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IGB31_RS25570	COG0778	Nitroreductase
IGB31_RS25575	COG1797	cobyrinic acid a,c-diamide synthase activity
IGB31_RS25600	COG0791	NLP P60 protein
IGB31_RS25605	COG0791	NLP P60 protein