locus-tag	class	description
PF1751_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PF1751_RS00010	COG0592	DNA-directed DNA polymerase activity
PF1751_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PF1751_RS00020	COG0187	DNA topoisomerase II activity
PF1751_RS00025	COG0745	RESPONSE REGULATOR receiver
PF1751_RS00040	COG5002	protein histidine kinase activity
PF1751_RS00050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PF1751_RS00055	COG0751	glycine-tRNA ligase activity
PF1751_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
PF1751_RS00065	COG2818	Glycosylase
PF1751_RS00080	COG0569	domain protein
PF1751_RS00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PF1751_RS00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PF1751_RS00095	COG0242	peptide deformylase activity
PF1751_RS00105	COG0758	DNA mediated transformation
PF1751_RS00110	COG0009	L-threonylcarbamoyladenylate synthase
PF1751_RS00120	COG0408	coproporphyrinogen oxidase activity
PF1751_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF1751_RS00140	COG3119	arylsulfatase activity
PF1751_RS00145	COG0583	DNA-binding transcription factor activity
PF1751_RS00155	COG3734	2-keto-3-deoxy-galactonokinase
PF1751_RS00160	COG0800	Aldolase
PF1751_RS00165	COG4948	Mandelate Racemase Muconate Lactonizing
PF1751_RS00170	COG2271	Major facilitator Superfamily
PF1751_RS00180	COG0159	tryptophan synthase activity
PF1751_RS00200	COG3360	Dodecin
PF1751_RS00210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF1751_RS00215	COG1764	response to oxidative stress
PF1751_RS00240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF1751_RS00245	COG0339	signal peptide processing
PF1751_RS00290	COG0659	secondary active sulfate transmembrane transporter activity
PF1751_RS00300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF1751_RS00305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF1751_RS00310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PF1751_RS00340	COG0109	protoheme IX farnesyltransferase activity
PF1751_RS00350	COG1464	Belongs to the NlpA lipoprotein family
PF1751_RS00355	COG2011	ABC-type metal ion transport system permease component
PF1751_RS00360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF1751_RS00375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF1751_RS00380	COG1121	(ABC) transporter
PF1751_RS00385	COG0735	belongs to the Fur family
PF1751_RS00390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PF1751_RS00410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PF1751_RS00415	COG3245	cytochrome
PF1751_RS00425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF1751_RS00440	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF1751_RS00445	COG5002	protein histidine kinase activity
PF1751_RS00450	COG2204	response regulator
PF1751_RS00470	COG1301	dicarboxylic acid transport
PF1751_RS00475	COG0700	Nucleoside recognition
PF1751_RS00490	COG1127	ABC transporter
PF1751_RS00495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF1751_RS00505	COG0612	Peptidase, M16
PF1751_RS00510	COG1283	sodium-dependent phosphate transmembrane transporter activity
PF1751_RS00515	COG0861	Integral membrane protein TerC family
PF1751_RS00520	COG2851	Citrate transporter
PF1751_RS00555	COG0427	acetyl-CoA hydrolase
PF1751_RS00575	COG0583	DNA-binding transcription factor activity
PF1751_RS00580	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS00585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF1751_RS00620	COG0840	transmembrane signaling receptor activity
PF1751_RS00630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF1751_RS00645	COG1802	Transcriptional regulator
PF1751_RS00650	COG2175	clavaminate synthase activity
PF1751_RS00665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF1751_RS00695	COG1595	DNA-templated transcription, initiation
PF1751_RS00700	COG3712	iron ion homeostasis
PF1751_RS00705	COG4774	siderophore transport
PF1751_RS00735	COG1289	transmembrane transporter activity
PF1751_RS00765	COG0457	Tetratricopeptide repeat
PF1751_RS00770	COG1649	PFAM Uncharacterised BCR, COG1649
PF1751_RS00770	COG0726	polysaccharide deacetylase
PF1751_RS00775	COG1215	transferase activity, transferring glycosyl groups
PF1751_RS00785	COG2831	hemolysin activation secretion protein
PF1751_RS00830	COG2304	oxidoreductase activity
PF1751_RS00835	COG1595	DNA-templated transcription, initiation
PF1751_RS00910	COG0582	viral genome integration into host DNA
PF1751_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS00925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF1751_RS00930	COG0745	RESPONSE REGULATOR receiver
PF1751_RS00935	COG2199	diguanylate cyclase activity
PF1751_RS00955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF1751_RS00965	COG4208	sulfate ABC transporter
PF1751_RS00970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PF1751_RS00980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF1751_RS01000	COG2807	transmembrane transport
PF1751_RS01005	COG0583	DNA-binding transcription factor activity
PF1751_RS01025	COG0765	amino acid transport
PF1751_RS01030	COG0765	amino acid transport
PF1751_RS01035	COG1126	abc transporter atp-binding protein
PF1751_RS01040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS01055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS01060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF1751_RS01070	COG2011	ABC-type metal ion transport system permease component
PF1751_RS01075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF1751_RS01105	COG1126	abc transporter atp-binding protein
PF1751_RS01110	COG0765	amino acid transport
PF1751_RS01115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS01125	COG1045	serine acetyltransferase
PF1751_RS01130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF1751_RS01140	COG0667	Aldo Keto reductase
PF1751_RS01145	COG2175	clavaminate synthase activity
PF1751_RS01150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF1751_RS01155	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PF1751_RS01160	COG4521	taurine ABC transporter
PF1751_RS01165	COG2918	glutathione biosynthetic process
PF1751_RS01175	COG2183	response to ionizing radiation
PF1751_RS01190	COG0189	ligase activity
PF1751_RS01195	COG0189	ligase activity
PF1751_RS01195	COG4067	protein conserved in archaea
PF1751_RS01200	COG3287	FIST C domain
PF1751_RS01200	COG2199	diguanylate cyclase activity
PF1751_RS01200	COG2200	EAL domain
PF1751_RS01205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF1751_RS01215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PF1751_RS01220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PF1751_RS01240	COG2184	nucleotidyltransferase activity
PF1751_RS01250	COG0514	ATP-dependent DNA helicase (RecQ)
PF1751_RS01255	COG0824	Thioesterase
PF1751_RS01265	COG0243	molybdopterin cofactor binding
PF1751_RS01270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF1751_RS01280	COG1652	LysM domain
PF1751_RS01285	COG1011	Hydrolase
PF1751_RS01290	COG0494	nUDIX hydrolase
PF1751_RS01295	COG1218	3'(2'),5'-bisphosphate nucleotidase
PF1751_RS01330	COG1088	dTDP-glucose 4,6-dehydratase activity
PF1751_RS01335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF1751_RS01340	COG2957	Belongs to the agmatine deiminase family
PF1751_RS01360	COG1942	4-Oxalocrotonate Tautomerase
PF1751_RS01365	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS01390	COG2342	PFAM TM1410 hypothetical-related protein
PF1751_RS01415	COG0438	transferase activity, transferring glycosyl groups
PF1751_RS01470	COG1192	Involved in chromosome partitioning
PF1751_RS01540	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PF1751_RS01545	COG1194	a g-specific adenine glycosylase
PF1751_RS01555	COG2223	nitrite transmembrane transporter activity
PF1751_RS01560	COG0131	Imidazoleglycerol-phosphate dehydratase
PF1751_RS01565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF1751_RS01575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PF1751_RS01580	COG0107	imidazoleglycerol-phosphate synthase activity
PF1751_RS01590	COG2861	carbohydrate metabolic process
PF1751_RS01595	COG0793	Belongs to the peptidase S41A family
PF1751_RS01600	COG4942	peptidase
PF1751_RS01605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF1751_RS01610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF1751_RS01620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PF1751_RS01640	COG3852	Histidine kinase
PF1751_RS01660	COG0301	tRNA thio-modification
PF1751_RS01660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF1751_RS01665	COG1217	gtp-binding protein TYPA
PF1751_RS01675	COG0058	SHG alpha-glucan phosphorylase activity
PF1751_RS01690	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PF1751_RS01700	COG3040	lipid binding
PF1751_RS01705	COG0402	S-adenosylhomocysteine deaminase activity
PF1751_RS01710	COG2188	Transcriptional regulator
PF1751_RS01720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PF1751_RS01725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF1751_RS01735	COG4176	ABC-type proline glycine betaine transport system permease component
PF1751_RS01740	COG0517	IMP dehydrogenase activity
PF1751_RS01740	COG4175	Glycine betaine
PF1751_RS01745	COG2986	histidine ammonia-lyase
PF1751_RS01750	COG2986	histidine ammonia-lyase
PF1751_RS01755	COG1113	amino acid transport
PF1751_RS01760	COG1228	amidohydrolase
PF1751_RS01780	COG0596	Alpha beta hydrolase
PF1751_RS01785	COG1490	D-aminoacyl-tRNA deacylase activity
PF1751_RS01790	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PF1751_RS01795	COG2943	transferase activity, transferring hexosyl groups
PF1751_RS01805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS01810	COG0765	amino acid transport
PF1751_RS01815	COG1126	abc transporter atp-binding protein
PF1751_RS01820	COG0840	transmembrane signaling receptor activity
PF1751_RS01825	COG0840	transmembrane signaling receptor activity
PF1751_RS01840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF1751_RS01845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF1751_RS01850	COG0140	phosphoribosyl-ATP diphosphatase activity
PF1751_RS01855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF1751_RS01860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PF1751_RS01870	COG2226	methyltransferase
PF1751_RS01890	COG1309	transcriptional regulator
PF1751_RS01915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PF1751_RS01920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PF1751_RS01930	COG0018	arginyl-trna synthetase
PF1751_RS01935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF1751_RS01940	COG0254	rRNA binding
PF1751_RS01950	COG0281	malic enzyme
PF1751_RS01980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PF1751_RS01985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PF1751_RS02000	COG0070	glutamate synthase
PF1751_RS02000	COG0067	glutamate synthase
PF1751_RS02000	COG0069	glutamate synthase activity
PF1751_RS02005	COG0493	'glutamate synthase
PF1751_RS02010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PF1751_RS02015	COG2814	Major facilitator Superfamily
PF1751_RS02020	COG0583	DNA-binding transcription factor activity
PF1751_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF1751_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS02045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF1751_RS02055	COG2226	methyltransferase
PF1751_RS02080	COG2986	histidine ammonia-lyase
PF1751_RS02095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF1751_RS02105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF1751_RS02110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF1751_RS02125	COG1192	Involved in chromosome partitioning
PF1751_RS02135	COG3118	belongs to the thioredoxin family
PF1751_RS02140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PF1751_RS02145	COG3264	Mechanosensitive ion channel
PF1751_RS02145	COG1196	nuclear chromosome segregation
PF1751_RS02150	COG3263	regulation of cellular component size
PF1751_RS02170	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS02175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF1751_RS02175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PF1751_RS02175	COG0506	proline dehydrogenase activity
PF1751_RS02180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF1751_RS02195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PF1751_RS02200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF1751_RS02220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PF1751_RS02225	COG0859	PFAM glycosyl transferase family 9
PF1751_RS02230	COG0859	PFAM glycosyl transferase family 9
PF1751_RS02235	COG0438	transferase activity, transferring glycosyl groups
PF1751_RS02260	COG4772	TonB-dependent receptor
PF1751_RS02265	COG2192	nodulation
PF1751_RS02280	COG0438	transferase activity, transferring glycosyl groups
PF1751_RS02285	COG1215	transferase activity, transferring glycosyl groups
PF1751_RS02295	COG1132	(ABC) transporter
PF1751_RS02300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PF1751_RS02300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PF1751_RS02305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF1751_RS02315	COG0667	Aldo Keto reductase
PF1751_RS02330	COG0583	DNA-binding transcription factor activity
PF1751_RS02335	COG1519	Transferase
PF1751_RS02340	COG1538	Outer membrane efflux protein
PF1751_RS02345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PF1751_RS02360	COG0494	nUDIX hydrolase
PF1751_RS02370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF1751_RS02375	COG3150	esterase
PF1751_RS02405	COG3830	Belongs to the UPF0237 family
PF1751_RS02405	COG0560	Phosphoserine phosphatase
PF1751_RS02410	COG0688	phosphatidylethanolamine metabolic process
PF1751_RS02435	COG1162	GTPase activity
PF1751_RS02440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PF1751_RS02445	COG2860	membrane
PF1751_RS02455	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PF1751_RS02455	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF1751_RS02460	COG0802	atpase or kinase
PF1751_RS02465	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF1751_RS02470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF1751_RS02475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PF1751_RS02480	COG1923	regulation of RNA biosynthetic process
PF1751_RS02485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF1751_RS02490	COG0330	HflC and HflK could
PF1751_RS02495	COG0330	HflC and HflK could
PF1751_RS02500	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PF1751_RS02505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PF1751_RS02515	COG1178	ABC-type Fe3 transport system permease component
PF1751_RS02520	COG1840	ABC-type Fe3 transport system, periplasmic component
PF1751_RS02535	COG0557	exoribonuclease II activity
PF1751_RS02540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF1751_RS02545	COG0360	Binds together with S18 to 16S ribosomal RNA
PF1751_RS02550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PF1751_RS02560	COG0359	binds to the 23S rRNA
PF1751_RS02565	COG0305	Participates in initiation and elongation during chromosome replication
PF1751_RS02570	COG1032	radical SAM domain protein
PF1751_RS02590	COG2307	Protein conserved in bacteria
PF1751_RS02590	COG2308	Evidence 4 Homologs of previously reported genes of
PF1751_RS02610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF1751_RS02615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PF1751_RS02620	COG0583	DNA-binding transcription factor activity
PF1751_RS02625	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS02630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS02660	COG4221	oxidoreductase activity
PF1751_RS02680	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PF1751_RS02685	COG0830	nickel cation binding
PF1751_RS02690	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PF1751_RS02695	COG0791	NLP P60 protein
PF1751_RS02700	COG1309	transcriptional regulator
PF1751_RS02710	COG2982	Protein involved in outer membrane biogenesis
PF1751_RS02720	COG0583	DNA-binding transcription factor activity
PF1751_RS02725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF1751_RS02730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PF1751_RS02735	COG0697	spore germination
PF1751_RS02740	COG2207	Transcriptional regulator
PF1751_RS02755	COG0443	Heat shock 70 kDa protein
PF1751_RS02760	COG0484	heat shock protein binding
PF1751_RS02765	COG0804	urea catabolic process
PF1751_RS02770	COG0832	Belongs to the urease beta subunit family
PF1751_RS02785	COG0831	urea catabolic process
PF1751_RS02790	COG0829	nickel cation binding
PF1751_RS02800	COG0411	ABC transporter
PF1751_RS02825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF1751_RS02835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PF1751_RS02880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF1751_RS02905	COG2095	MarC family integral membrane protein
PF1751_RS02915	COG0151	Belongs to the GarS family
PF1751_RS02920	COG0138	bifunctional purine biosynthesis protein purh
PF1751_RS02930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF1751_RS02940	COG2264	protein methyltransferase activity
PF1751_RS02955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PF1751_RS02980	COG0023	Translation Initiation Factor
PF1751_RS02985	COG1166	arginine decarboxylase activity
PF1751_RS02990	COG0534	Mate efflux family protein
PF1751_RS02995	COG2373	Large extracellular alpha-helical protein
PF1751_RS03005	COG4953	penicillin-binding protein 1C
PF1751_RS03015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF1751_RS03085	COG4964	Belongs to the GSP D family
PF1751_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS03145	COG2217	Heavy metal translocating P-type atpase
PF1751_RS03160	COG2814	Major facilitator Superfamily
PF1751_RS03170	COG0604	alcohol dehydrogenase
PF1751_RS03175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF1751_RS03180	COG0583	DNA-binding transcription factor activity
PF1751_RS03190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PF1751_RS03195	COG0387	Pfam Sodium calcium exchanger
PF1751_RS03215	COG1309	transcriptional regulator
PF1751_RS03220	COG2233	PERMEase
PF1751_RS03265	COG2995	paraquat-inducible protein a
PF1751_RS03270	COG2995	paraquat-inducible protein a
PF1751_RS03275	COG3008	intermembrane lipid transfer
PF1751_RS03300	COG0456	acetyltransferase
PF1751_RS03310	COG0288	reversible hydration of carbon dioxide
PF1751_RS03330	COG2031	fatty acid transporter
PF1751_RS03335	COG0477	Major facilitator Superfamily
PF1751_RS03385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF1751_RS03405	COG1496	oxidoreductase activity
PF1751_RS03410	COG0405	Gamma-glutamyltransferase
PF1751_RS03425	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
PF1751_RS03465	COG1157	protein secretion by the type III secretion system
PF1751_RS03480	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF1751_RS03490	COG4794	Type iii secretion
PF1751_RS03500	COG4792	protein secretion
PF1751_RS03540	COG4669	(LipO)protein
PF1751_RS03555	COG0012	GTP binding
PF1751_RS03560	COG0193	aminoacyl-tRNA hydrolase activity
PF1751_RS03565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PF1751_RS03570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF1751_RS03580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PF1751_RS03585	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PF1751_RS03595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PF1751_RS03600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PF1751_RS03610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF1751_RS03615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF1751_RS03635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PF1751_RS03650	COG4221	oxidoreductase activity
PF1751_RS03660	COG0415	Belongs to the DNA photolyase family
PF1751_RS03665	COG0789	Transcriptional regulator
PF1751_RS03680	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PF1751_RS03685	COG1090	epimerase
PF1751_RS03690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PF1751_RS03700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF1751_RS03710	COG0175	sulfate reduction
PF1751_RS03720	COG0204	Acyl-transferase
PF1751_RS03725	COG0280	phosphate acetyltransferase
PF1751_RS03725	COG0857	belongs to the CobB CobQ family
PF1751_RS03740	COG0268	Binds directly to 16S ribosomal RNA
PF1751_RS03750	COG0196	riboflavin kinase activity
PF1751_RS03755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF1751_RS03760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PF1751_RS03765	COG1047	Peptidyl-prolyl cis-trans
PF1751_RS03770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PF1751_RS03800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS03825	COG0542	response to heat
PF1751_RS03850	COG1252	NADH dehydrogenase
PF1751_RS03880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PF1751_RS03885	COG0237	dephospho-CoA kinase activity
PF1751_RS03930	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF1751_RS03950	COG0084	hydrolase, TatD family'
PF1751_RS03955	COG1609	Transcriptional regulator
PF1751_RS03965	COG1105	Belongs to the carbohydrate kinase PfkB family
PF1751_RS03970	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PF1751_RS03970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF1751_RS03970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF1751_RS03980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF1751_RS03985	COG4774	siderophore transport
PF1751_RS03990	COG3128	pkhd-type hydroxylase
PF1751_RS04000	COG0019	diaminopimelate decarboxylase activity
PF1751_RS04025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PF1751_RS04040	COG4608	Belongs to the ABC transporter superfamily
PF1751_RS04045	COG0444	Belongs to the ABC transporter superfamily
PF1751_RS04050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF1751_RS04055	COG0601	transmembrane transport
PF1751_RS04060	COG0747	negative chemotaxis
PF1751_RS04070	COG0747	negative chemotaxis
PF1751_RS04075	COG0747	negative chemotaxis
PF1751_RS04080	COG0747	negative chemotaxis
PF1751_RS04095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PF1751_RS04100	COG4178	(ABC) transporter
PF1751_RS04115	COG0180	Tryptophanyl-tRNA synthetase
PF1751_RS04120	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF1751_RS04130	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS04135	COG0667	Aldo Keto reductase
PF1751_RS04140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PF1751_RS04145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF1751_RS04150	COG0723	plastoquinol--plastocyanin reductase activity
PF1751_RS04155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF1751_RS04160	COG2857	Cytochrome c1
PF1751_RS04165	COG0625	glutathione transferase activity
PF1751_RS04170	COG2969	positive regulation of protein catabolic process
PF1751_RS04175	COG2186	Transcriptional regulator
PF1751_RS04190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF1751_RS04200	COG2271	Major facilitator Superfamily
PF1751_RS04205	COG2721	sulfolactate sulfo-lyase activity
PF1751_RS04215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF1751_RS04225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF1751_RS04230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF1751_RS04235	COG0154	amidase activity
PF1751_RS04240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF1751_RS04245	COG1077	Cell shape determining protein MreB Mrl
PF1751_RS04250	COG1792	Involved in formation and maintenance of cell shape
PF1751_RS04260	COG0424	maF-like protein
PF1751_RS04265	COG1530	ribonuclease E activity
PF1751_RS04275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF1751_RS04280	COG0312	modulator of DNA gyrase
PF1751_RS04285	COG3028	Belongs to the UPF0307 family
PF1751_RS04290	COG0312	modulator of DNA gyrase
PF1751_RS04325	COG1660	Displays ATPase and GTPase activities
PF1751_RS04335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PF1751_RS04340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PF1751_RS04345	COG1137	ATPase activity
PF1751_RS04350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PF1751_RS04360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PF1751_RS04370	COG1127	ABC transporter
PF1751_RS04375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PF1751_RS04380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PF1751_RS04400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF1751_RS04410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF1751_RS04415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF1751_RS04420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PF1751_RS04430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PF1751_RS04435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PF1751_RS04495	COG2135	peptidase activity
PF1751_RS04500	COG0840	transmembrane signaling receptor activity
PF1751_RS04505	COG0501	Belongs to the peptidase M48B family
PF1751_RS04510	COG2119	membrane
PF1751_RS04515	COG2813	Specifically methylates the guanine in position
PF1751_RS04520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF1751_RS04525	COG1280	lysine exporter protein (LysE YggA)
PF1751_RS04530	COG0318	PFAM AMP-dependent synthetase and ligase
PF1751_RS04550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF1751_RS04555	COG2885	chlorophyll binding
PF1751_RS04560	COG2823	Periplasmic or secreted lipoprotein
PF1751_RS04565	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PF1751_RS04570	COG0792	nuclease activity
PF1751_RS04585	COG2001	Belongs to the MraZ family
PF1751_RS04590	COG0275	rRNA processing
PF1751_RS04605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF1751_RS04610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF1751_RS04615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF1751_RS04620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF1751_RS04625	COG0772	Belongs to the SEDS family
PF1751_RS04630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF1751_RS04635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF1751_RS04640	COG1181	Belongs to the D-alanine--D-alanine ligase family
PF1751_RS04655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF1751_RS04660	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PF1751_RS04665	COG5001	Diguanylate cyclase
PF1751_RS04665	COG4251	negative regulation of phosphorylation
PF1751_RS04665	COG3706	GGDEF domain
PF1751_RS04665	COG2203	Gaf domain
PF1751_RS04675	COG5002	protein histidine kinase activity
PF1751_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS04715	COG0784	Response regulator, receiver
PF1751_RS04715	COG0835	chemotaxis
PF1751_RS04725	COG0583	DNA-binding transcription factor activity
PF1751_RS04745	COG1566	PFAM secretion protein HlyD family protein
PF1751_RS04755	COG0477	Major facilitator Superfamily
PF1751_RS04765	COG0300	oxidoreductase activity
PF1751_RS04780	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PF1751_RS04780	COG0662	Cupin 2, conserved barrel domain protein
PF1751_RS04795	COG1696	Membrane protein involved in D-alanine export
PF1751_RS04810	COG3420	alginic acid biosynthetic process
PF1751_RS04820	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PF1751_RS04825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS04830	COG1215	transferase activity, transferring glycosyl groups
PF1751_RS04850	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PF1751_RS04855	COG0315	cyclic pyranopterin monophosphate synthase activity
PF1751_RS04860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PF1751_RS04880	COG0513	Belongs to the DEAD box helicase family
PF1751_RS04885	COG0400	carboxylic ester hydrolase activity
PF1751_RS04890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS04895	COG4597	amino acid ABC transporter
PF1751_RS04900	COG0765	amino acid transport
PF1751_RS04905	COG1126	abc transporter atp-binding protein
PF1751_RS04910	COG2186	Transcriptional regulator
PF1751_RS04915	COG2807	transmembrane transport
PF1751_RS04930	COG3188	usher protein
PF1751_RS04935	COG3121	Chaperone
PF1751_RS04960	COG3539	Fimbrial protein
PF1751_RS04980	COG2827	Endonuclease containing a URI domain
PF1751_RS04990	COG4774	siderophore transport
PF1751_RS04995	COG2027	D-alanyl-D-alanine carboxypeptidase
PF1751_RS05005	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PF1751_RS05010	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF1751_RS05030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF1751_RS05060	COG0814	amino acid
PF1751_RS05065	COG1760	l-serine dehydratase
PF1751_RS05070	COG0583	DNA-binding transcription factor activity
PF1751_RS05080	COG4772	TonB-dependent receptor
PF1751_RS05085	COG3712	iron ion homeostasis
PF1751_RS05090	COG1595	DNA-templated transcription, initiation
PF1751_RS05115	COG3712	iron ion homeostasis
PF1751_RS05125	COG3081	Nucleoid-associated protein
PF1751_RS05135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PF1751_RS05140	COG0525	valine-tRNA ligase activity
PF1751_RS05155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PF1751_RS05160	COG0795	lipopolysaccharide-transporting ATPase activity
PF1751_RS05165	COG0795	lipopolysaccharide-transporting ATPase activity
PF1751_RS05170	COG0481	GTPase activity
PF1751_RS05175	COG0681	Belongs to the peptidase S26 family
PF1751_RS05180	COG0571	ribonuclease III activity
PF1751_RS05185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF1751_RS05190	COG1381	Involved in DNA repair and RecF pathway recombination
PF1751_RS05195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PF1751_RS05205	COG0590	tRNA wobble adenosine to inosine editing
PF1751_RS05210	COG0500	methyltransferase
PF1751_RS05215	COG2226	methyltransferase
PF1751_RS05230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF1751_RS05270	COG0523	cobalamin synthesis protein
PF1751_RS05290	COG4206	TonB-dependent receptor
PF1751_RS05295	COG4628	conserved protein (DUF2132)
PF1751_RS05315	COG3188	usher protein
PF1751_RS05320	COG3121	Chaperone
PF1751_RS05330	COG3539	Fimbrial protein
PF1751_RS05340	COG3539	Fimbrial protein
PF1751_RS05350	COG2375	cellular response to nickel ion
PF1751_RS05355	COG1695	Transcriptional regulator
PF1751_RS05385	COG1113	amino acid transport
PF1751_RS05395	COG0069	glutamate synthase activity
PF1751_RS05405	COG2205	protein histidine kinase activity
PF1751_RS05410	COG1858	cytochrome C peroxidase
PF1751_RS05435	COG0583	DNA-binding transcription factor activity
PF1751_RS05445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF1751_RS05465	COG2076	Multidrug Resistance protein
PF1751_RS05485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF1751_RS05500	COG4191	Histidine kinase
PF1751_RS05505	COG2204	response regulator
PF1751_RS05525	COG1126	abc transporter atp-binding protein
PF1751_RS05530	COG0765	amino acid transport
PF1751_RS05535	COG0765	amino acid transport
PF1751_RS05540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS05555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF1751_RS05565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF1751_RS05570	COG3842	ATPase activity
PF1751_RS05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PF1751_RS05580	COG0243	molybdopterin cofactor binding
PF1751_RS05585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PF1751_RS05600	COG0450	alkyl hydroperoxide reductase
PF1751_RS05605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF1751_RS05610	COG0418	dihydroorotase activity
PF1751_RS05620	COG0137	argininosuccinate synthase activity
PF1751_RS05625	COG2197	response regulator
PF1751_RS05635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF1751_RS05640	COG2878	Part of a membrane complex involved in electron transport
PF1751_RS05645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF1751_RS05645	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF1751_RS05650	COG0489	protein tyrosine kinase activity
PF1751_RS05655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PF1751_RS05660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PF1751_RS05770	COG3179	chitinase
PF1751_RS05780	COG1546	Belongs to the CinA family
PF1751_RS05785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PF1751_RS05790	COG2137	regulation of response to DNA damage stimulus
PF1751_RS05805	COG3148	PFAM DTW domain containing protein
PF1751_RS05820	COG0583	DNA-binding transcription factor activity
PF1751_RS05835	COG4807	Protein conserved in bacteria
PF1751_RS05850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF1751_RS05855	COG3158	transport of potassium into the cell
PF1751_RS05860	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS05865	COG2311	Membrane
PF1751_RS05880	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PF1751_RS05885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PF1751_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS05895	COG1177	transmembrane transport
PF1751_RS05900	COG1176	ABC-type spermidine putrescine transport system, permease component I
PF1751_RS05905	COG3842	ATPase activity
PF1751_RS05910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PF1751_RS05920	COG0583	DNA-binding transcription factor activity
PF1751_RS05930	COG0840	transmembrane signaling receptor activity
PF1751_RS05940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF1751_RS05940	COG0457	Tetratricopeptide repeat
PF1751_RS05955	COG2201	protein-glutamate methylesterase activity
PF1751_RS05960	COG2203	Gaf domain
PF1751_RS05960	COG3706	GGDEF domain
PF1751_RS05960	COG4251	negative regulation of phosphorylation
PF1751_RS05960	COG5001	Diguanylate cyclase
PF1751_RS05975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PF1751_RS05995	COG1073	alpha beta
PF1751_RS06015	COG2885	chlorophyll binding
PF1751_RS06030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PF1751_RS06035	COG0563	adenylate kinase activity
PF1751_RS06040	COG1214	PFAM Peptidase M22, glycoprotease
PF1751_RS06070	COG0742	ribosomal rna small subunit methyltransferase
PF1751_RS06080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS06105	COG2937	Belongs to the GPAT DAPAT family
PF1751_RS06120	COG2226	methyltransferase
PF1751_RS06125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF1751_RS06130	COG1215	transferase activity, transferring glycosyl groups
PF1751_RS06135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF1751_RS06140	COG2166	iron-sulfur cluster assembly
PF1751_RS06145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF1751_RS06150	COG2171	N-acyltransferase activity
PF1751_RS06155	COG1393	Belongs to the ArsC family
PF1751_RS06160	COG0025	NhaP-type Na H and K H
PF1751_RS06165	COG0436	Aminotransferase
PF1751_RS06170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PF1751_RS06180	COG0052	Belongs to the universal ribosomal protein uS2 family
PF1751_RS06185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PF1751_RS06190	COG0528	UMP kinase activity
PF1751_RS06195	COG0233	cytoplasmic translational termination
PF1751_RS06200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF1751_RS06210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PF1751_RS06230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF1751_RS06235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF1751_RS06240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF1751_RS06245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF1751_RS06250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF1751_RS06255	COG0587	DNA-directed DNA polymerase activity
PF1751_RS06260	COG0825	malonyl-CoA metabolic process
PF1751_RS06265	COG0037	tRNA processing
PF1751_RS06270	COG0504	CTP synthase activity
PF1751_RS06275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PF1751_RS06280	COG0148	phosphopyruvate hydratase activity
PF1751_RS06290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PF1751_RS06300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PF1751_RS06305	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PF1751_RS06310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PF1751_RS06315	COG0585	pseudouridine synthase activity
PF1751_RS06320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PF1751_RS06325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PF1751_RS06340	COG1278	Cold shock
PF1751_RS06345	COG0717	Belongs to the dCTP deaminase family
PF1751_RS06360	COG1201	RNA secondary structure unwinding
PF1751_RS06390	COG1793	dna ligase
PF1751_RS06400	COG2366	antibiotic biosynthetic process
PF1751_RS06405	COG0625	glutathione transferase activity
PF1751_RS06410	COG1120	ATPase activity
PF1751_RS06415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF1751_RS06430	COG4774	siderophore transport
PF1751_RS06445	COG0653	protein targeting
PF1751_RS06455	COG3012	SEC-C Motif Domain Protein
PF1751_RS06480	COG1199	ATP-dependent helicase activity
PF1751_RS06500	COG0259	pyridoxamine-phosphate oxidase activity
PF1751_RS06510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF1751_RS06520	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PF1751_RS06535	COG0583	DNA-binding transcription factor activity
PF1751_RS06550	COG3220	belongs to the UPF0276 family
PF1751_RS06605	COG2271	Major facilitator Superfamily
PF1751_RS06610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF1751_RS06630	COG0583	DNA-binding transcription factor activity
PF1751_RS06645	COG0306	phosphate transporter
PF1751_RS06655	COG1414	Transcriptional regulator
PF1751_RS06660	COG2814	Major facilitator Superfamily
PF1751_RS06665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF1751_RS06670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF1751_RS06675	COG0183	Belongs to the thiolase family
PF1751_RS06680	COG3485	protocatechuate 3,4-dioxygenase
PF1751_RS06685	COG3485	protocatechuate 3,4-dioxygenase
PF1751_RS06690	COG0477	Major facilitator Superfamily
PF1751_RS06700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF1751_RS06705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF1751_RS06735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS06740	COG1309	transcriptional regulator
PF1751_RS06745	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS06750	COG2814	Major facilitator Superfamily
PF1751_RS06795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF1751_RS06805	COG1704	LemA family
PF1751_RS06825	COG0697	spore germination
PF1751_RS06830	COG1629	transport
PF1751_RS06840	COG1595	DNA-templated transcription, initiation
PF1751_RS06845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF1751_RS06850	COG0235	Class ii aldolase
PF1751_RS06855	COG1396	sequence-specific DNA binding
PF1751_RS06865	COG1454	alcohol dehydrogenase
PF1751_RS06875	COG0156	8-amino-7-oxononanoate synthase activity
PF1751_RS06890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF1751_RS06895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF1751_RS06900	COG2271	Major facilitator Superfamily
PF1751_RS06925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF1751_RS06930	COG0583	DNA-binding transcription factor activity
PF1751_RS06935	COG2814	Major facilitator Superfamily
PF1751_RS06960	COG2267	carboxylic ester hydrolase activity
PF1751_RS06990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PF1751_RS07045	COG0642	Histidine kinase
PF1751_RS07060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PF1751_RS07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF1751_RS07100	COG0425	Belongs to the sulfur carrier protein TusA family
PF1751_RS07110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF1751_RS07120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF1751_RS07125	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PF1751_RS07130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PF1751_RS07135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PF1751_RS07150	COG0582	viral genome integration into host DNA
PF1751_RS07170	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
PF1751_RS07360	COG3179	chitinase
PF1751_RS07375	COG2135	peptidase activity
PF1751_RS07395	COG1192	Involved in chromosome partitioning
PF1751_RS07420	COG0583	DNA-binding transcription factor activity
PF1751_RS07425	COG0477	Major facilitator Superfamily
PF1751_RS07440	COG0583	DNA-binding transcription factor activity
PF1751_RS07460	COG1802	Transcriptional regulator
PF1751_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS07470	COG3246	L-lysine catabolic process to acetate
PF1751_RS07505	COG2807	transmembrane transport
PF1751_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS07520	COG0583	DNA-binding transcription factor activity
PF1751_RS07525	COG2910	NAD(P)H-binding
PF1751_RS07535	COG0583	DNA-binding transcription factor activity
PF1751_RS07560	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PF1751_RS07570	COG0583	DNA-binding transcription factor activity
PF1751_RS07585	COG0174	glutamine synthetase
PF1751_RS07600	COG3100	YcgL domain-containing protein
PF1751_RS07605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF1751_RS07620	COG2983	Belongs to the UPF0260 family
PF1751_RS07665	COG1770	oligopeptidase
PF1751_RS07675	COG0121	glutamine amidotransferase
PF1751_RS07685	COG0583	DNA-binding transcription factor activity
PF1751_RS07690	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PF1751_RS07695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PF1751_RS07700	COG1984	allophanate hydrolase subunit 2
PF1751_RS07715	COG0542	response to heat
PF1751_RS07725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF1751_RS07740	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PF1751_RS07745	COG0425	Belongs to the sulfur carrier protein TusA family
PF1751_RS07755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF1751_RS07765	COG1132	(ABC) transporter
PF1751_RS07770	COG0741	lytic transglycosylase activity
PF1751_RS07775	COG0488	(ABC) transporter
PF1751_RS07780	COG0589	response to stress
PF1751_RS07790	COG1024	Enoyl-CoA hydratase
PF1751_RS07790	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF1751_RS07795	COG0183	Belongs to the thiolase family
PF1751_RS07840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF1751_RS07850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF1751_RS07865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF1751_RS07870	COG0584	glycerophosphoryl diester phosphodiesterase
PF1751_RS07880	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF1751_RS07885	COG1136	(ABC) transporter
PF1751_RS07890	COG4591	ABC-type transport system involved in lipoprotein release permease component
PF1751_RS07910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PF1751_RS07910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PF1751_RS07925	COG2853	Lipoprotein
PF1751_RS07935	COG2204	response regulator
PF1751_RS07945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF1751_RS07955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF1751_RS07985	COG2814	Major facilitator Superfamily
PF1751_RS07990	COG0579	oxidoreductase
PF1751_RS07995	COG0583	DNA-binding transcription factor activity
PF1751_RS08030	COG1611	Belongs to the LOG family
PF1751_RS08040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PF1751_RS08060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF1751_RS08065	COG0583	DNA-binding transcription factor activity
PF1751_RS08070	COG2814	Major facilitator Superfamily
PF1751_RS08080	COG2233	PERMEase
PF1751_RS08090	COG2197	response regulator
PF1751_RS08095	COG0596	Alpha beta hydrolase
PF1751_RS08105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF1751_RS08120	COG0747	negative chemotaxis
PF1751_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS08130	COG0546	phosphoglycolate phosphatase activity
PF1751_RS08135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF1751_RS08140	COG0402	S-adenosylhomocysteine deaminase activity
PF1751_RS08145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PF1751_RS08155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PF1751_RS08165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PF1751_RS08170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF1751_RS08175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PF1751_RS08190	COG0776	regulation of translation
PF1751_RS08200	COG1086	Polysaccharide biosynthesis protein
PF1751_RS08220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF1751_RS08260	COG0028	Belongs to the TPP enzyme family
PF1751_RS08275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF1751_RS08280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF1751_RS08280	COG0543	2 iron, 2 sulfur cluster binding
PF1751_RS08285	COG1555	photosystem II stabilization
PF1751_RS08315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PF1751_RS08325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PF1751_RS08330	COG2205	protein histidine kinase activity
PF1751_RS08335	COG0745	RESPONSE REGULATOR receiver
PF1751_RS08370	COG3209	COG3209 Rhs family protein
PF1751_RS08370	COG3209	COG3209 Rhs family protein
PF1751_RS08380	COG0084	hydrolase, TatD family'
PF1751_RS08385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PF1751_RS08390	COG2259	Doxx family
PF1751_RS08410	COG1131	(ABC) transporter
PF1751_RS08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF1751_RS08425	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PF1751_RS08430	COG4181	ATPase activity
PF1751_RS08445	COG1376	ErfK ybiS ycfS ynhG family protein
PF1751_RS08475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF1751_RS08495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF1751_RS08510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PF1751_RS08520	COG1764	response to oxidative stress
PF1751_RS08525	COG1846	Transcriptional regulator
PF1751_RS08530	COG0583	DNA-binding transcription factor activity
PF1751_RS08535	COG0730	response to heat
PF1751_RS08540	COG0583	DNA-binding transcription factor activity
PF1751_RS08550	COG3214	Protein conserved in bacteria
PF1751_RS08555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PF1751_RS08575	COG3384	dioxygenase
PF1751_RS08580	COG0500	methyltransferase
PF1751_RS08585	COG0501	Belongs to the peptidase M48B family
PF1751_RS08590	COG0436	Aminotransferase
PF1751_RS08595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF1751_RS08600	COG0386	Belongs to the glutathione peroxidase family
PF1751_RS08605	COG1846	Transcriptional regulator
PF1751_RS08610	COG0784	Response regulator, receiver
PF1751_RS08610	COG2205	protein histidine kinase activity
PF1751_RS08610	COG5002	protein histidine kinase activity
PF1751_RS08620	COG1956	GAF domain-containing protein
PF1751_RS08625	COG2205	protein histidine kinase activity
PF1751_RS08625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS08630	COG2197	response regulator
PF1751_RS08665	COG0004	ammonium transporteR
PF1751_RS08685	COG0564	pseudouridine synthase activity
PF1751_RS08695	COG0746	molybdenum cofactor guanylyltransferase activity
PF1751_RS08700	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF1751_RS08705	COG0303	'Molybdopterin
PF1751_RS08710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF1751_RS08720	COG4133	protoheme IX ABC transporter activity
PF1751_RS08740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PF1751_RS08745	COG1138	Cytochrome C-type biogenesis protein
PF1751_RS08755	COG3088	subunit of a heme lyase
PF1751_RS08760	COG4235	cytochrome complex assembly
PF1751_RS08770	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
PF1751_RS08795	COG2814	Major facilitator Superfamily
PF1751_RS08805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PF1751_RS08810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF1751_RS08820	COG0469	pyruvate kinase activity
PF1751_RS08830	COG2084	Dehydrogenase
PF1751_RS08835	COG3622	Belongs to the hyi family
PF1751_RS08840	COG3960	tartronate-semialdehyde synthase activity
PF1751_RS08855	COG1309	transcriptional regulator
PF1751_RS08860	COG2354	Protein conserved in bacteria
PF1751_RS08865	COG2853	Lipoprotein
PF1751_RS08885	COG2113	Glycine betaine
PF1751_RS08890	COG3162	membrane
PF1751_RS08895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF1751_RS08905	COG2009	succinate dehydrogenase
PF1751_RS08910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PF1751_RS08915	COG1053	succinate dehydrogenase
PF1751_RS08920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF1751_RS08935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF1751_RS08940	COG0045	succinate-CoA ligase (ADP-forming) activity
PF1751_RS08975	COG0326	Molecular chaperone. Has ATPase activity
PF1751_RS08985	COG1741	Belongs to the pirin family
PF1751_RS09000	COG0840	transmembrane signaling receptor activity
PF1751_RS09015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF1751_RS09020	COG2205	protein histidine kinase activity
PF1751_RS09020	COG5002	protein histidine kinase activity
PF1751_RS09020	COG0784	Response regulator, receiver
PF1751_RS09030	COG4771	TonB-dependent receptor
PF1751_RS09035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PF1751_RS09050	COG1022	Amp-dependent synthetase and ligase
PF1751_RS09075	COG0628	permease
PF1751_RS09090	COG0284	orotidine-5'-phosphate decarboxylase activity
PF1751_RS09095	COG2130	NADP-dependent
PF1751_RS09110	COG0840	transmembrane signaling receptor activity
PF1751_RS09160	COG3217	Mosc domain protein beta barrel domain protein
PF1751_RS09160	COG0633	Ferredoxin
PF1751_RS09175	COG0811	peptide transport
PF1751_RS09195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF1751_RS09200	COG3540	Alkaline phosphatase
PF1751_RS09205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PF1751_RS09230	COG0625	glutathione transferase activity
PF1751_RS09235	COG1131	(ABC) transporter
PF1751_RS09240	COG0842	Transport permease protein
PF1751_RS09270	COG2076	Multidrug Resistance protein
PF1751_RS09275	COG0385	Bile acid
PF1751_RS09280	COG2974	May be involved in recombination
PF1751_RS09325	COG2010	Cytochrome c
PF1751_RS09330	COG0545	Peptidyl-prolyl cis-trans isomerase
PF1751_RS09350	COG2200	EAL domain
PF1751_RS09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF1751_RS09360	COG3321	synthase
PF1751_RS09360	COG4221	oxidoreductase activity
PF1751_RS09360	COG0604	alcohol dehydrogenase
PF1751_RS09370	COG3842	ATPase activity
PF1751_RS09380	COG1176	ABC-type spermidine putrescine transport system, permease component I
PF1751_RS09405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF1751_RS09410	COG1121	(ABC) transporter
PF1751_RS09440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PF1751_RS09445	COG0066	3-isopropylmalate dehydratase activity
PF1751_RS09450	COG0583	DNA-binding transcription factor activity
PF1751_RS09455	COG1301	dicarboxylic acid transport
PF1751_RS09460	COG0596	Alpha beta hydrolase
PF1751_RS09480	COG3829	transcription factor binding
PF1751_RS09490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF1751_RS09495	COG0431	NADPH-dependent FMN reductase
PF1751_RS09515	COG0583	DNA-binding transcription factor activity
PF1751_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS09540	COG5006	permease, DMT superfamily
PF1751_RS09570	COG0768	penicillin binding
PF1751_RS09590	COG0417	DNA replication proofreading
PF1751_RS09615	COG0728	peptidoglycan biosynthetic process
PF1751_RS09660	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PF1751_RS09660	COG0662	Cupin 2, conserved barrel domain protein
PF1751_RS09665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF1751_RS09675	COG3712	iron ion homeostasis
PF1751_RS09680	COG1595	DNA-templated transcription, initiation
PF1751_RS09695	COG4977	sequence-specific DNA binding
PF1751_RS09710	COG3387	PFAM Glycoside hydrolase 15-related
PF1751_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS09720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF1751_RS09725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF1751_RS09735	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS09765	COG1595	DNA-templated transcription, initiation
PF1751_RS09775	COG4772	TonB-dependent receptor
PF1751_RS09790	COG2223	nitrite transmembrane transporter activity
PF1751_RS09795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PF1751_RS09815	COG3675	Pfam Lipase (class 3)
PF1751_RS09820	COG0402	S-adenosylhomocysteine deaminase activity
PF1751_RS09830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF1751_RS09835	COG1051	belongs to the nudix hydrolase family
PF1751_RS09840	COG1476	TRANSCRIPTIONal
PF1751_RS09850	COG0720	synthase
PF1751_RS09880	COG0840	transmembrane signaling receptor activity
PF1751_RS09885	COG2056	Na+-H+ antiporter family
PF1751_RS09890	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF1751_RS09900	COG0826	peptidase U32
PF1751_RS09920	COG0628	permease
PF1751_RS09940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF1751_RS09945	COG3132	Protein of unknown function, DUF480
PF1751_RS09955	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PF1751_RS09965	COG0583	DNA-binding transcription factor activity
PF1751_RS09975	COG1253	flavin adenine dinucleotide binding
PF1751_RS09980	COG0709	Synthesizes selenophosphate from selenide and ATP
PF1751_RS09985	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PF1751_RS09990	COG0701	Predicted permease
PF1751_RS10000	COG0625	glutathione transferase activity
PF1751_RS10005	COG0384	phenazine biosynthesis protein PhzF
PF1751_RS10010	COG0113	porphobilinogen synthase activity
PF1751_RS10015	COG1280	lysine exporter protein (LysE YggA)
PF1751_RS10045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF1751_RS10050	COG0583	DNA-binding transcription factor activity
PF1751_RS10060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF1751_RS10065	COG0517	IMP dehydrogenase activity
PF1751_RS10070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF1751_RS10095	COG4335	DNA alkylation repair
PF1751_RS10100	COG0174	glutamine synthetase
PF1751_RS10115	COG2814	Major facilitator Superfamily
PF1751_RS10145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF1751_RS10165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF1751_RS10175	COG2197	response regulator
PF1751_RS10180	COG2205	protein histidine kinase activity
PF1751_RS10180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS10190	COG0656	L-ascorbic acid biosynthetic process
PF1751_RS10200	COG1024	Enoyl-CoA hydratase
PF1751_RS10205	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS10220	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF1751_RS10225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PF1751_RS10245	COG0322	excinuclease ABC activity
PF1751_RS10265	COG0784	Response regulator, receiver
PF1751_RS10265	COG4191	Histidine kinase
PF1751_RS10280	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS10280	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF1751_RS10285	COG2113	Glycine betaine
PF1751_RS10295	COG2271	Major facilitator Superfamily
PF1751_RS10310	COG5002	protein histidine kinase activity
PF1751_RS10315	COG0745	RESPONSE REGULATOR receiver
PF1751_RS10355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF1751_RS10390	COG4214	carbohydrate transport
PF1751_RS10395	COG1129	ABC transporter
PF1751_RS10400	COG4213	ABC transporter substrate-binding protein
PF1751_RS10405	COG2115	Belongs to the xylose isomerase family
PF1751_RS10410	COG2207	Transcriptional regulator
PF1751_RS10410	COG1609	Transcriptional regulator
PF1751_RS10430	COG3781	membrane
PF1751_RS10435	COG0640	Transcriptional regulator
PF1751_RS10440	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS10470	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS10480	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS10485	COG1129	ABC transporter
PF1751_RS10490	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS10510	COG2207	Transcriptional regulator
PF1751_RS10520	COG0625	glutathione transferase activity
PF1751_RS10535	COG0673	inositol 2-dehydrogenase activity
PF1751_RS10575	COG1968	undecaprenyl-diphosphatase activity
PF1751_RS10585	COG0747	negative chemotaxis
PF1751_RS10620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF1751_RS10635	COG1309	transcriptional regulator
PF1751_RS10645	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS10650	COG0604	alcohol dehydrogenase
PF1751_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS10650	COG3321	synthase
PF1751_RS10685	COG1064	alcohol dehydrogenase
PF1751_RS10790	COG1522	sequence-specific DNA binding
PF1751_RS10835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF1751_RS10845	COG0583	DNA-binding transcription factor activity
PF1751_RS10875	COG0475	glutathione-regulated potassium exporter activity
PF1751_RS10875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF1751_RS10885	COG0697	spore germination
PF1751_RS10890	COG0367	asparagine synthase
PF1751_RS10900	COG1024	Enoyl-CoA hydratase
PF1751_RS10905	COG2207	Transcriptional regulator
PF1751_RS11015	COG1177	transmembrane transport
PF1751_RS11020	COG1176	ABC-type spermidine putrescine transport system, permease component I
PF1751_RS11025	COG3842	ATPase activity
PF1751_RS11030	COG1414	Transcriptional regulator
PF1751_RS11040	COG2205	protein histidine kinase activity
PF1751_RS11040	COG2198	Histidine kinase
PF1751_RS11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS11040	COG0784	Response regulator, receiver
PF1751_RS11060	COG3842	ATPase activity
PF1751_RS11075	COG0114	fumarate hydratase activity
PF1751_RS11080	COG1301	dicarboxylic acid transport
PF1751_RS11090	COG2188	Transcriptional regulator
PF1751_RS11110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF1751_RS11120	COG0534	Mate efflux family protein
PF1751_RS11125	COG1309	transcriptional regulator
PF1751_RS11190	COG1522	sequence-specific DNA binding
PF1751_RS11195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF1751_RS11210	COG3284	Transcriptional regulator
PF1751_RS11215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF1751_RS11220	COG0022	dehydrogenase e1 component
PF1751_RS11235	COG0174	glutamine synthetase
PF1751_RS11245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS11250	COG0583	DNA-binding transcription factor activity
PF1751_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS11270	COG5002	protein histidine kinase activity
PF1751_RS11275	COG0745	RESPONSE REGULATOR receiver
PF1751_RS11300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF1751_RS11310	COG3718	enzyme involved in inositol metabolism
PF1751_RS11325	COG0673	inositol 2-dehydrogenase activity
PF1751_RS11330	COG0673	inositol 2-dehydrogenase activity
PF1751_RS11340	COG1129	ABC transporter
PF1751_RS11345	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS11405	COG4774	siderophore transport
PF1751_RS11425	COG4251	negative regulation of phosphorylation
PF1751_RS11425	COG3706	GGDEF domain
PF1751_RS11425	COG2203	Gaf domain
PF1751_RS11425	COG5001	Diguanylate cyclase
PF1751_RS11440	COG1595	DNA-templated transcription, initiation
PF1751_RS11465	COG0616	signal peptide processing
PF1751_RS11475	COG0583	DNA-binding transcription factor activity
PF1751_RS11485	COG2376	Dihydroxyacetone kinase
PF1751_RS11490	COG1063	alcohol dehydrogenase
PF1751_RS11495	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS11500	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS11505	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS11510	COG1129	ABC transporter
PF1751_RS11515	COG0698	ribose 5-phosphate isomerase
PF1751_RS11520	COG2390	Transcriptional regulator
PF1751_RS11525	COG1253	flavin adenine dinucleotide binding
PF1751_RS11545	COG0765	amino acid transport
PF1751_RS11550	COG0765	amino acid transport
PF1751_RS11580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF1751_RS11590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF1751_RS11595	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS11600	COG2610	gluconate transmembrane transporter activity
PF1751_RS11605	COG3829	transcription factor binding
PF1751_RS11605	COG3290	protein histidine kinase activity
PF1751_RS11610	COG4172	Belongs to the ABC transporter superfamily
PF1751_RS11615	COG4239	(ABC) transporter, permease
PF1751_RS11620	COG4174	ABC transporter (Permease)
PF1751_RS11625	COG4166	transmembrane transport
PF1751_RS11630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF1751_RS11635	COG4172	Belongs to the ABC transporter superfamily
PF1751_RS11640	COG4239	(ABC) transporter, permease
PF1751_RS11645	COG4174	ABC transporter (Permease)
PF1751_RS11650	COG4166	transmembrane transport
PF1751_RS11655	COG4166	transmembrane transport
PF1751_RS11660	COG0741	lytic transglycosylase activity
PF1751_RS11660	COG1388	LysM domain
PF1751_RS11665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF1751_RS11675	COG0328	RNA-DNA hybrid ribonuclease activity
PF1751_RS11680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF1751_RS11690	COG0456	acetyltransferase
PF1751_RS11710	COG0431	NADPH-dependent FMN reductase
PF1751_RS11715	COG0028	Belongs to the TPP enzyme family
PF1751_RS11725	COG0789	Transcriptional regulator
PF1751_RS11740	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS11760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PF1751_RS11760	COG0316	Belongs to the HesB IscA family
PF1751_RS11810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF1751_RS11815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF1751_RS11825	COG3139	Protein of unknown function (DUF1315)
PF1751_RS11835	COG0308	aminopeptidase N
PF1751_RS11840	COG0667	Aldo Keto reductase
PF1751_RS11855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF1751_RS11875	COG2194	sulfuric ester hydrolase activity
PF1751_RS11880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PF1751_RS11885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PF1751_RS11890	COG0561	phosphatase activity
PF1751_RS11980	COG2233	PERMEase
PF1751_RS12000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF1751_RS12010	COG1609	Transcriptional regulator
PF1751_RS12025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS12030	COG0745	RESPONSE REGULATOR receiver
PF1751_RS12035	COG2205	protein histidine kinase activity
PF1751_RS12045	COG1595	DNA-templated transcription, initiation
PF1751_RS12060	COG0730	response to heat
PF1751_RS12070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF1751_RS12080	COG0189	ligase activity
PF1751_RS12085	COG0598	Magnesium transport protein CorA
PF1751_RS12090	COG0024	Methionine aminopeptidase
PF1751_RS12100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF1751_RS12125	COG1070	Carbohydrate kinase
PF1751_RS12145	COG1175	transmembrane transport
PF1751_RS12190	COG1538	Outer membrane efflux protein
PF1751_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS12210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS12215	COG0348	domain, Protein
PF1751_RS12225	COG1285	pathogenesis
PF1751_RS12240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PF1751_RS12250	COG0784	Response regulator, receiver
PF1751_RS12250	COG4191	Histidine kinase
PF1751_RS12260	COG2814	Major facilitator Superfamily
PF1751_RS12290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF1751_RS12295	COG3318	Belongs to the UPF0149 family
PF1751_RS12295	COG3012	SEC-C Motif Domain Protein
PF1751_RS12300	COG0038	chloride channel
PF1751_RS12305	COG1024	Enoyl-CoA hydratase
PF1751_RS12310	COG2816	NAD+ diphosphatase activity
PF1751_RS12340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF1751_RS12365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PF1751_RS12375	COG1595	DNA-templated transcription, initiation
PF1751_RS12380	COG3712	iron ion homeostasis
PF1751_RS12385	COG1116	anion transmembrane transporter activity
PF1751_RS12390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF1751_RS12395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS12405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PF1751_RS12410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF1751_RS12420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF1751_RS12435	COG2271	Major facilitator Superfamily
PF1751_RS12440	COG1335	isochorismatase
PF1751_RS12445	COG3473	Maleate cis-trans isomerase
PF1751_RS12450	COG0596	Alpha beta hydrolase
PF1751_RS12455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF1751_RS12460	COG2309	aminopeptidase activity
PF1751_RS12465	COG1846	Transcriptional regulator
PF1751_RS12470	COG2080	2 iron, 2 sulfur cluster binding
PF1751_RS12475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF1751_RS12475	COG2010	Cytochrome c
PF1751_RS12480	COG1309	transcriptional regulator
PF1751_RS12500	COG0840	transmembrane signaling receptor activity
PF1751_RS12505	COG1968	undecaprenyl-diphosphatase activity
PF1751_RS12520	COG0583	DNA-binding transcription factor activity
PF1751_RS12525	COG0583	DNA-binding transcription factor activity
PF1751_RS12555	COG3685	Protein conserved in bacteria
PF1751_RS12570	COG2323	membrane
PF1751_RS12595	COG5001	Diguanylate cyclase
PF1751_RS12595	COG2203	Gaf domain
PF1751_RS12595	COG4251	negative regulation of phosphorylation
PF1751_RS12595	COG3706	GGDEF domain
PF1751_RS12600	COG3546	catalase activity
PF1751_RS12605	COG3685	Protein conserved in bacteria
PF1751_RS12745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF1751_RS12765	COG0667	Aldo Keto reductase
PF1751_RS12775	COG1199	ATP-dependent helicase activity
PF1751_RS12775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF1751_RS12830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF1751_RS12845	COG0488	(ABC) transporter
PF1751_RS12875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PF1751_RS12885	COG2133	pyrroloquinoline quinone binding
PF1751_RS12900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF1751_RS12905	COG2822	iron ion transport
PF1751_RS12915	COG2822	iron ion transport
PF1751_RS12920	COG0672	)-iron permease
PF1751_RS12925	COG2207	Transcriptional regulator
PF1751_RS12945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS12965	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF1751_RS13000	COG1132	(ABC) transporter
PF1751_RS13005	COG2375	cellular response to nickel ion
PF1751_RS13005	COG1132	(ABC) transporter
PF1751_RS13010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF1751_RS13010	COG3433	isochorismatase activity
PF1751_RS13010	COG2226	methyltransferase
PF1751_RS13015	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF1751_RS13015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF1751_RS13035	COG4771	TonB-dependent receptor
PF1751_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS13070	COG4948	Mandelate Racemase Muconate Lactonizing
PF1751_RS13085	COG0667	Aldo Keto reductase
PF1751_RS13095	COG0477	Major facilitator Superfamily
PF1751_RS13115	COG2207	Transcriptional regulator
PF1751_RS13120	COG0300	oxidoreductase activity
PF1751_RS13130	COG0604	alcohol dehydrogenase
PF1751_RS13130	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS13130	COG3321	synthase
PF1751_RS13140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS13155	COG0210	DNA helicase
PF1751_RS13170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS13190	COG1113	amino acid transport
PF1751_RS13235	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PF1751_RS13250	COG1199	ATP-dependent helicase activity
PF1751_RS13250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF1751_RS13255	COG2267	carboxylic ester hydrolase activity
PF1751_RS13270	COG2308	Evidence 4 Homologs of previously reported genes of
PF1751_RS13305	COG0697	spore germination
PF1751_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS13365	COG3038	cytochrome b561
PF1751_RS13375	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS13380	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS13385	COG1609	Transcriptional regulator
PF1751_RS13390	COG1070	Carbohydrate kinase
PF1751_RS13395	COG1522	sequence-specific DNA binding
PF1751_RS13405	COG0826	peptidase U32
PF1751_RS13415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF1751_RS13435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PF1751_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS13540	COG2814	Major facilitator Superfamily
PF1751_RS13545	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS13550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF1751_RS13560	COG0463	Glycosyl transferase, family 2
PF1751_RS13565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF1751_RS13565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PF1751_RS13570	COG0726	polysaccharide deacetylase
PF1751_RS13575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF1751_RS13580	COG2076	Multidrug Resistance protein
PF1751_RS13585	COG2076	Multidrug Resistance protein
PF1751_RS13605	COG1024	Enoyl-CoA hydratase
PF1751_RS13610	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS13615	COG1024	Enoyl-CoA hydratase
PF1751_RS13620	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS13625	COG0183	Belongs to the thiolase family
PF1751_RS13635	COG3781	membrane
PF1751_RS13645	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PF1751_RS13660	COG2205	protein histidine kinase activity
PF1751_RS13660	COG0784	Response regulator, receiver
PF1751_RS13660	COG5002	protein histidine kinase activity
PF1751_RS13670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF1751_RS13675	COG2205	protein histidine kinase activity
PF1751_RS13675	COG2198	Histidine kinase
PF1751_RS13675	COG0784	Response regulator, receiver
PF1751_RS13700	COG3278	Belongs to the heme-copper respiratory oxidase family
PF1751_RS13710	COG1794	racemase activity, acting on amino acids and derivatives
PF1751_RS13715	COG1247	-acetyltransferase
PF1751_RS13740	COG1929	Belongs to the glycerate kinase type-1 family
PF1751_RS13745	COG3835	regulator
PF1751_RS13750	COG2271	Major facilitator Superfamily
PF1751_RS13760	COG0583	DNA-binding transcription factor activity
PF1751_RS13765	COG0667	Aldo Keto reductase
PF1751_RS13785	COG0583	DNA-binding transcription factor activity
PF1751_RS13790	COG2200	EAL domain
PF1751_RS13865	COG3145	DNA-N1-methyladenine dioxygenase activity
PF1751_RS13870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF1751_RS13870	COG2169	Transcriptional regulator
PF1751_RS13890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PF1751_RS13900	COG0488	(ABC) transporter
PF1751_RS13920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF1751_RS13930	COG0640	Transcriptional regulator
PF1751_RS13940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF1751_RS13945	COG0431	NADPH-dependent FMN reductase
PF1751_RS13950	COG2207	Transcriptional regulator
PF1751_RS13950	COG1917	Cupin 2, conserved barrel domain protein
PF1751_RS14020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF1751_RS14025	COG0581	inorganic phosphate transmembrane transporter activity
PF1751_RS14035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF1751_RS14065	COG0531	amino acid
PF1751_RS14070	COG3938	Belongs to the proline racemase family
PF1751_RS14075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF1751_RS14085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS14105	COG0583	DNA-binding transcription factor activity
PF1751_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS14145	COG2366	antibiotic biosynthetic process
PF1751_RS14160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF1751_RS14165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS14170	COG1116	anion transmembrane transporter activity
PF1751_RS14170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS14190	COG0583	DNA-binding transcription factor activity
PF1751_RS14195	COG0667	Aldo Keto reductase
PF1751_RS14215	COG1238	metal cluster binding
PF1751_RS14220	COG2267	carboxylic ester hydrolase activity
PF1751_RS14225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF1751_RS14230	COG0297	glycogen (starch) synthase activity
PF1751_RS14235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PF1751_RS14240	COG1640	4-alpha-glucanotransferase
PF1751_RS14295	COG1113	amino acid transport
PF1751_RS14305	COG1522	sequence-specific DNA binding
PF1751_RS14330	COG2814	Major facilitator Superfamily
PF1751_RS14335	COG0583	DNA-binding transcription factor activity
PF1751_RS14340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF1751_RS14375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF1751_RS14380	COG1944	ATP diphosphatase activity
PF1751_RS14385	COG0840	transmembrane signaling receptor activity
PF1751_RS14415	COG0583	DNA-binding transcription factor activity
PF1751_RS14435	COG1247	-acetyltransferase
PF1751_RS14455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF1751_RS14455	COG2146	nitrite reductase [NAD(P)H] activity
PF1751_RS14460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF1751_RS14460	COG2146	nitrite reductase [NAD(P)H] activity
PF1751_RS14465	COG0243	molybdopterin cofactor binding
PF1751_RS14495	COG0456	acetyltransferase
PF1751_RS14495	COG1846	Transcriptional regulator
PF1751_RS14500	COG2271	Major facilitator Superfamily
PF1751_RS14505	COG0519	Catalyzes the synthesis of GMP from XMP
PF1751_RS14520	COG5001	Diguanylate cyclase
PF1751_RS14520	COG3300	MHYT domain
PF1751_RS14525	COG2207	Transcriptional regulator
PF1751_RS14530	COG2223	nitrite transmembrane transporter activity
PF1751_RS14535	COG5001	Diguanylate cyclase
PF1751_RS14535	COG3300	MHYT domain
PF1751_RS14580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS14585	COG0697	spore germination
PF1751_RS14590	COG2353	YceI-like domain
PF1751_RS14640	COG2079	MmgE PrpD family protein
PF1751_RS14645	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS14650	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
PF1751_RS14655	COG0583	DNA-binding transcription factor activity
PF1751_RS14675	COG2205	protein histidine kinase activity
PF1751_RS14680	COG0745	RESPONSE REGULATOR receiver
PF1751_RS14695	COG0589	response to stress
PF1751_RS14710	COG0814	amino acid
PF1751_RS14730	COG1335	isochorismatase
PF1751_RS14735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF1751_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS14750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF1751_RS14765	COG2818	Glycosylase
PF1751_RS14800	COG0714	Associated with various cellular activities
PF1751_RS14830	COG0420	3'-5' exonuclease activity
PF1751_RS14850	COG2706	6-phosphogluconolactonase activity
PF1751_RS14875	COG0673	inositol 2-dehydrogenase activity
PF1751_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
PF1751_RS14885	COG0183	Belongs to the thiolase family
PF1751_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS14900	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS14930	COG3239	Fatty acid desaturase
PF1751_RS14935	COG2267	carboxylic ester hydrolase activity
PF1751_RS14955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF1751_RS14965	COG0515	serine threonine protein kinase
PF1751_RS15050	COG0656	L-ascorbic acid biosynthetic process
PF1751_RS15065	COG0596	Alpha beta hydrolase
PF1751_RS15075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PF1751_RS15080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF1751_RS15115	COG0625	glutathione transferase activity
PF1751_RS15145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF1751_RS15150	COG3842	ATPase activity
PF1751_RS15155	COG1177	transmembrane transport
PF1751_RS15160	COG1175	transmembrane transport
PF1751_RS15170	COG1609	Transcriptional regulator
PF1751_RS15175	COG0019	diaminopimelate decarboxylase activity
PF1751_RS15190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS15195	COG0765	amino acid transport
PF1751_RS15200	COG1126	abc transporter atp-binding protein
PF1751_RS15205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS15215	COG2066	Belongs to the glutaminase family
PF1751_RS15235	COG2207	Transcriptional regulator
PF1751_RS15245	COG0673	inositol 2-dehydrogenase activity
PF1751_RS15265	COG5383	Protein conserved in bacteria
PF1751_RS15285	COG4191	Histidine kinase
PF1751_RS15285	COG0784	Response regulator, receiver
PF1751_RS15290	COG0587	DNA-directed DNA polymerase activity
PF1751_RS15305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF1751_RS15310	COG3209	COG3209 Rhs family protein
PF1751_RS15310	COG3209	COG3209 Rhs family protein
PF1751_RS15330	COG0494	nUDIX hydrolase
PF1751_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS15345	COG1304	FMN binding
PF1751_RS15350	COG1349	DNA-binding transcription factor activity
PF1751_RS15370	COG0693	protein deglycase activity
PF1751_RS15395	COG0840	transmembrane signaling receptor activity
PF1751_RS15410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF1751_RS15410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PF1751_RS15425	COG2181	nitrate reductase activity
PF1751_RS15430	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
PF1751_RS15435	COG1140	nitrate reductase beta subunit
PF1751_RS15440	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PF1751_RS15445	COG2223	nitrite transmembrane transporter activity
PF1751_RS15455	COG3850	Histidine kinase
PF1751_RS15460	COG2197	response regulator
PF1751_RS15465	COG3154	lipid carrier protein
PF1751_RS15470	COG0826	peptidase U32
PF1751_RS15475	COG0826	peptidase U32
PF1751_RS15480	COG0303	'Molybdopterin
PF1751_RS15485	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF1751_RS15520	COG1999	signal sequence binding
PF1751_RS15540	COG0589	response to stress
PF1751_RS15545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF1751_RS15555	COG0589	response to stress
PF1751_RS15570	COG1063	alcohol dehydrogenase
PF1751_RS15610	COG1595	DNA-templated transcription, initiation
PF1751_RS15630	COG1280	lysine exporter protein (LysE YggA)
PF1751_RS15660	COG2814	Major facilitator Superfamily
PF1751_RS15670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF1751_RS15675	COG3209	COG3209 Rhs family protein
PF1751_RS15675	COG3209	COG3209 Rhs family protein
PF1751_RS15695	COG3706	GGDEF domain
PF1751_RS15710	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PF1751_RS15730	COG0235	Class ii aldolase
PF1751_RS15735	COG0583	DNA-binding transcription factor activity
PF1751_RS15745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF1751_RS15750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS15755	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS15775	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
PF1751_RS15785	COG5001	Diguanylate cyclase
PF1751_RS15785	COG3447	MASE1 domain protein
PF1751_RS15785	COG5002	protein histidine kinase activity
PF1751_RS15795	COG0583	DNA-binding transcription factor activity
PF1751_RS15800	COG1335	isochorismatase
PF1751_RS15820	COG1917	Cupin 2, conserved barrel domain protein
PF1751_RS15820	COG4977	sequence-specific DNA binding
PF1751_RS15840	COG1741	Belongs to the pirin family
PF1751_RS15850	COG1116	anion transmembrane transporter activity
PF1751_RS15855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF1751_RS15870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS15875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS15885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PF1751_RS15890	COG2814	Major facilitator Superfamily
PF1751_RS15935	COG0395	ABC-type sugar transport system, permease component
PF1751_RS15945	COG3842	ATPase activity
PF1751_RS15950	COG3842	ATPase activity
PF1751_RS15955	COG3284	Transcriptional regulator
PF1751_RS15965	COG1595	DNA-templated transcription, initiation
PF1751_RS16015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PF1751_RS16020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF1751_RS16025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PF1751_RS16030	COG2835	tetraacyldisaccharide 4'-kinase activity
PF1751_RS16035	COG1663	tetraacyldisaccharide 4'-kinase activity
PF1751_RS16040	COG0848	biopolymer transport protein
PF1751_RS16045	COG0811	peptide transport
PF1751_RS16050	COG2333	competence protein COMEC
PF1751_RS16050	COG0658	competence protein
PF1751_RS16070	COG5002	protein histidine kinase activity
PF1751_RS16070	COG2205	protein histidine kinase activity
PF1751_RS16070	COG0784	Response regulator, receiver
PF1751_RS16075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF1751_RS16095	COG1393	Belongs to the ArsC family
PF1751_RS16115	COG0037	tRNA processing
PF1751_RS16125	COG3091	SprT-like family
PF1751_RS16130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF1751_RS16150	COG2920	part of a sulfur-relay system
PF1751_RS16155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF1751_RS16160	COG0435	Glutathione S-transferase
PF1751_RS16165	COG1648	precorrin-2 dehydrogenase activity
PF1751_RS16165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF1751_RS16170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PF1751_RS16175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF1751_RS16180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF1751_RS16185	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF1751_RS16190	COG1674	ftsk spoiiie
PF1751_RS16195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PF1751_RS16200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PF1751_RS16205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PF1751_RS16210	COG0542	response to heat
PF1751_RS16215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PF1751_RS16220	COG1278	Cold shock
PF1751_RS16240	COG0482	sulfurtransferase activity
PF1751_RS16245	COG2915	High frequency lysogenization protein hflD homolog
PF1751_RS16255	COG2850	peptidyl-arginine hydroxylation
PF1751_RS16260	COG2153	protein acetylation
PF1751_RS16270	COG2224	Isocitrate lyase
PF1751_RS16275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF1751_RS16280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF1751_RS16285	COG0649	NAD binding
PF1751_RS16285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF1751_RS16300	COG1034	ATP synthesis coupled electron transport
PF1751_RS16305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PF1751_RS16310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PF1751_RS16320	COG0713	ATP synthesis coupled electron transport
PF1751_RS16335	COG1007	ATP synthesis coupled electron transport
PF1751_RS16340	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
PF1751_RS16380	COG2814	Major facilitator Superfamily
PF1751_RS16395	COG3220	belongs to the UPF0276 family
PF1751_RS16445	COG0577	efflux transmembrane transporter activity
PF1751_RS16445	COG1136	(ABC) transporter
PF1751_RS16450	COG0577	efflux transmembrane transporter activity
PF1751_RS16450	COG1136	(ABC) transporter
PF1751_RS16460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS16525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF1751_RS16525	COG2111	Na H antiporter
PF1751_RS16530	COG1006	Multisubunit Na H antiporter MnhC subunit
PF1751_RS16535	COG0651	ATP synthesis coupled electron transport
PF1751_RS16545	COG2212	antiporter activity
PF1751_RS16550	COG1320	monovalent cation:proton antiporter activity
PF1751_RS16560	COG1733	regulation of RNA biosynthetic process
PF1751_RS16580	COG3340	Belongs to the peptidase S51 family
PF1751_RS16585	COG0215	cysteine-tRNA ligase activity
PF1751_RS16590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF1751_RS16600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PF1751_RS16605	COG2814	Major facilitator Superfamily
PF1751_RS16610	COG1566	PFAM secretion protein HlyD family protein
PF1751_RS16620	COG1846	Transcriptional regulator
PF1751_RS16625	COG0784	Response regulator, receiver
PF1751_RS16625	COG2205	protein histidine kinase activity
PF1751_RS16630	COG3300	MHYT domain
PF1751_RS16630	COG5001	Diguanylate cyclase
PF1751_RS16640	COG2197	response regulator
PF1751_RS16650	COG3121	Chaperone
PF1751_RS16660	COG2911	Protein conserved in bacteria
PF1751_RS16665	COG0729	surface antigen
PF1751_RS16675	COG0708	Exodeoxyribonuclease III
PF1751_RS16680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF1751_RS16685	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS16695	COG0789	Transcriptional regulator
PF1751_RS16705	COG0318	PFAM AMP-dependent synthetase and ligase
PF1751_RS16710	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS16715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF1751_RS16740	COG2866	Carboxypeptidase
PF1751_RS16750	COG2814	Major facilitator Superfamily
PF1751_RS16810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PF1751_RS16820	COG0217	transcriptional regulatory protein
PF1751_RS16835	COG0583	DNA-binding transcription factor activity
PF1751_RS16840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF1751_RS16845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF1751_RS16850	COG3038	cytochrome b561
PF1751_RS16860	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS16860	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF1751_RS16875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PF1751_RS16880	COG1846	Transcriptional regulator
PF1751_RS16885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PF1751_RS16895	COG0583	DNA-binding transcription factor activity
PF1751_RS16900	COG2814	Major facilitator Superfamily
PF1751_RS16905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF1751_RS16910	COG0776	regulation of translation
PF1751_RS16915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF1751_RS16920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PF1751_RS16925	COG0740	serine-type endopeptidase activity
PF1751_RS16930	COG0544	peptidyl-prolyl cis-trans isomerase activity
PF1751_RS16955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PF1751_RS16960	COG1686	Belongs to the peptidase S11 family
PF1751_RS16980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS17000	COG1953	Uracil, thiamine, allantoin
PF1751_RS17010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF1751_RS17010	COG0493	'glutamate synthase
PF1751_RS17020	COG1309	transcriptional regulator
PF1751_RS17035	COG1276	copper resistance
PF1751_RS17045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF1751_RS17055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PF1751_RS17090	COG4221	oxidoreductase activity
PF1751_RS17095	COG0471	metal ion transport
PF1751_RS17100	COG4191	Histidine kinase
PF1751_RS17120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF1751_RS17155	COG4585	Histidine kinase
PF1751_RS17170	COG1131	(ABC) transporter
PF1751_RS17190	COG0784	Response regulator, receiver
PF1751_RS17190	COG2205	protein histidine kinase activity
PF1751_RS17210	COG0640	Transcriptional regulator
PF1751_RS17220	COG1522	sequence-specific DNA binding
PF1751_RS17225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF1751_RS17230	COG0022	dehydrogenase e1 component
PF1751_RS17240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF1751_RS17245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF1751_RS17265	COG2423	ornithine cyclodeaminase activity
PF1751_RS17275	COG4215	(ABC) transporter
PF1751_RS17315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS17320	COG0577	efflux transmembrane transporter activity
PF1751_RS17320	COG1136	(ABC) transporter
PF1751_RS17335	COG2186	Transcriptional regulator
PF1751_RS17380	COG1609	Transcriptional regulator
PF1751_RS17385	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS17390	COG1070	Carbohydrate kinase
PF1751_RS17395	COG1063	alcohol dehydrogenase
PF1751_RS17400	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS17410	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS17460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF1751_RS17515	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS17520	COG3384	dioxygenase
PF1751_RS17530	COG2271	Major facilitator Superfamily
PF1751_RS17535	COG3971	2-oxopent-4-enoate hydratase activity
PF1751_RS17545	COG1846	Transcriptional regulator
PF1751_RS17550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS17585	COG0531	amino acid
PF1751_RS17595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF1751_RS17600	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS17605	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS17610	COG0251	oxidation-reduction process
PF1751_RS17630	COG0583	DNA-binding transcription factor activity
PF1751_RS17640	COG0625	glutathione transferase activity
PF1751_RS17645	COG0390	transport system, permease component
PF1751_RS17650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF1751_RS17695	COG1450	Type ii and iii secretion system protein
PF1751_RS17710	COG3166	PFAM Fimbrial assembly family protein
PF1751_RS17715	COG3156	type II secretion system protein K
PF1751_RS17730	COG2165	general secretion pathway protein
PF1751_RS17735	COG2165	general secretion pathway protein
PF1751_RS17740	COG1459	type II secretion system
PF1751_RS17745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF1751_RS17750	COG1120	ATPase activity
PF1751_RS17755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF1751_RS17760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF1751_RS17765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF1751_RS17770	COG4774	siderophore transport
PF1751_RS17785	COG0765	amino acid transport
PF1751_RS17790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS17810	COG0745	RESPONSE REGULATOR receiver
PF1751_RS17815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF1751_RS17845	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF1751_RS17915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF1751_RS17920	COG1309	transcriptional regulator
PF1751_RS17930	COG1063	alcohol dehydrogenase
PF1751_RS17935	COG2853	Lipoprotein
PF1751_RS17945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF1751_RS17955	COG2205	protein histidine kinase activity
PF1751_RS17960	COG0745	RESPONSE REGULATOR receiver
PF1751_RS17970	COG2135	peptidase activity
PF1751_RS17985	COG3179	chitinase
PF1751_RS18185	COG1484	DNA-dependent DNA replication
PF1751_RS18255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PF1751_RS18305	COG0270	DNA (cytosine-5-)-methyltransferase activity
PF1751_RS18355	COG0776	regulation of translation
PF1751_RS18360	COG0072	phenylalanine-tRNA ligase activity
PF1751_RS18365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PF1751_RS18370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PF1751_RS18375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PF1751_RS18380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PF1751_RS18385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PF1751_RS18395	COG1278	Cold shock
PF1751_RS18420	COG1869	D-ribose catabolic process
PF1751_RS18425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF1751_RS18430	COG1609	Transcriptional regulator
PF1751_RS18435	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS18440	COG1129	ABC transporter
PF1751_RS18445	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS18470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PF1751_RS18485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF1751_RS18505	COG5002	protein histidine kinase activity
PF1751_RS18545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS18580	COG1286	toxin biosynthetic process
PF1751_RS18585	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF1751_RS18590	COG0285	dihydrofolate synthase activity
PF1751_RS18595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PF1751_RS18600	COG0135	phosphoribosylanthranilate isomerase activity
PF1751_RS18625	COG0473	3-isopropylmalate dehydrogenase activity
PF1751_RS18630	COG2226	methyltransferase
PF1751_RS18635	COG0066	3-isopropylmalate dehydratase activity
PF1751_RS18640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PF1751_RS18670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF1751_RS18680	COG0596	Alpha beta hydrolase
PF1751_RS18710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF1751_RS18715	COG0556	nucleotide-excision repair
PF1751_RS18730	COG0583	DNA-binding transcription factor activity
PF1751_RS18735	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS18750	COG1864	DNA RNA non-specific endonuclease
PF1751_RS18750	COG3591	Belongs to the peptidase S1B family
PF1751_RS18755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF1751_RS18760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF1751_RS18765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PF1751_RS18785	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PF1751_RS18815	COG1280	lysine exporter protein (LysE YggA)
PF1751_RS18820	COG0583	DNA-binding transcription factor activity
PF1751_RS18870	COG4104	PAAR repeat-containing protein
PF1751_RS18905	COG2384	SAM-dependent methyltransferase
PF1751_RS18910	COG2186	Transcriptional regulator
PF1751_RS18925	COG4521	taurine ABC transporter
PF1751_RS18945	COG0235	Class ii aldolase
PF1751_RS18955	COG5285	phytanoyl-CoA dioxygenase
PF1751_RS18960	COG1126	abc transporter atp-binding protein
PF1751_RS18965	COG0583	DNA-binding transcription factor activity
PF1751_RS18975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PF1751_RS18985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF1751_RS19000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS19005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PF1751_RS19010	COG2391	methyltransferase activity
PF1751_RS19025	COG1309	transcriptional regulator
PF1751_RS19040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF1751_RS19045	COG0436	Aminotransferase
PF1751_RS19050	COG1301	dicarboxylic acid transport
PF1751_RS19065	COG1301	dicarboxylic acid transport
PF1751_RS19070	COG0583	DNA-binding transcription factor activity
PF1751_RS19075	COG0640	Transcriptional regulator
PF1751_RS19135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF1751_RS19145	COG0583	DNA-binding transcription factor activity
PF1751_RS19150	COG1304	FMN binding
PF1751_RS19165	COG5002	protein histidine kinase activity
PF1751_RS19165	COG5001	Diguanylate cyclase
PF1751_RS19180	COG1054	Belongs to the UPF0176 family
PF1751_RS19210	COG0271	Belongs to the BolA IbaG family
PF1751_RS19220	COG0114	fumarate hydratase activity
PF1751_RS19225	COG0697	spore germination
PF1751_RS19230	COG0183	Belongs to the thiolase family
PF1751_RS19235	COG2326	polyphosphate kinase activity
PF1751_RS19245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PF1751_RS19245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS19250	COG0367	asparagine synthase
PF1751_RS19255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF1751_RS19255	COG0189	ligase activity
PF1751_RS19260	COG1363	Peptidase, m42
PF1751_RS19265	COG3089	Belongs to the UPF0270 family
PF1751_RS19280	COG1368	sulfuric ester hydrolase activity
PF1751_RS19305	COG0318	PFAM AMP-dependent synthetase and ligase
PF1751_RS19315	COG2197	response regulator
PF1751_RS19320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PF1751_RS19330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PF1751_RS19335	COG1073	alpha beta
PF1751_RS19360	COG2840	Smr protein MutS2
PF1751_RS19365	COG0302	gtp cyclohydrolase
PF1751_RS19385	COG2851	Citrate transporter
PF1751_RS19390	COG0583	DNA-binding transcription factor activity
PF1751_RS19395	COG0625	glutathione transferase activity
PF1751_RS19400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS19410	COG2252	PERMEase
PF1751_RS19440	COG4266	Belongs to the allantoicase family
PF1751_RS19445	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PF1751_RS19455	COG2233	PERMEase
PF1751_RS19470	COG1560	Kdo2-lipid A biosynthetic process
PF1751_RS19475	COG0850	regulation of cytokinetic process
PF1751_RS19480	COG2894	cell division
PF1751_RS19485	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PF1751_RS19490	COG0564	pseudouridine synthase activity
PF1751_RS19495	COG1362	aminopeptidase activity
PF1751_RS19500	COG0668	transmembrane transport
PF1751_RS19505	COG1473	amidohydrolase
PF1751_RS19520	COG3023	N-Acetylmuramoyl-L-alanine amidase
PF1751_RS19525	COG0642	Histidine kinase
PF1751_RS19540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF1751_RS19590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF1751_RS19595	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS19615	COG3123	guanosine phosphorylase activity
PF1751_RS19620	COG3217	Mosc domain protein beta barrel domain protein
PF1751_RS19620	COG0633	Ferredoxin
PF1751_RS19635	COG3851	Histidine kinase
PF1751_RS19640	COG2197	response regulator
PF1751_RS19645	COG1597	lipid kinase activity
PF1751_RS19665	COG1192	Involved in chromosome partitioning
PF1751_RS19670	COG1360	Flagellar Motor Protein
PF1751_RS19675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF1751_RS19680	COG2201	protein-glutamate methylesterase activity
PF1751_RS19685	COG2198	Histidine kinase
PF1751_RS19685	COG0784	Response regulator, receiver
PF1751_RS19685	COG0643	Histidine kinase
PF1751_RS19690	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PF1751_RS19720	COG1278	Cold shock
PF1751_RS19730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF1751_RS19780	COG0745	RESPONSE REGULATOR receiver
PF1751_RS19815	COG1677	Flagellar hook-basal body complex protein FliE
PF1751_RS19845	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PF1751_RS19860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF1751_RS19880	COG1706	bacterial-type flagellum-dependent cell motility
PF1751_RS19885	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PF1751_RS19895	COG4787	bacterial-type flagellum-dependent cell motility
PF1751_RS19910	COG2154	pterin-4-alpha-carbinolamine dehydratase
PF1751_RS19925	COG2207	Transcriptional regulator
PF1751_RS19945	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF1751_RS19950	COG1846	Transcriptional regulator
PF1751_RS19955	COG0514	ATP-dependent DNA helicase (RecQ)
PF1751_RS19965	COG2832	Protein of unknown function (DUF454)
PF1751_RS19970	COG0784	Response regulator, receiver
PF1751_RS19970	COG2205	protein histidine kinase activity
PF1751_RS20015	COG1846	Transcriptional regulator
PF1751_RS20020	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PF1751_RS20025	COG0406	alpha-ribazole phosphatase activity
PF1751_RS20030	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PF1751_RS20040	COG1492	cobalamin metabolic process
PF1751_RS20050	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PF1751_RS20055	COG0778	Nitroreductase
PF1751_RS20060	COG1797	cobyrinic acid a,c-diamide synthase activity
PF1751_RS20070	COG0791	NLP P60 protein
PF1751_RS20075	COG0791	NLP P60 protein
PF1751_RS20080	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PF1751_RS20085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF1751_RS20100	COG1216	Glycosyl transferase, family 2
PF1751_RS20100	COG0438	transferase activity, transferring glycosyl groups
PF1751_RS20105	COG0628	permease
PF1751_RS20115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PF1751_RS20120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF1751_RS20135	COG3122	Protein conserved in bacteria
PF1751_RS20140	COG3956	TIGRFAM MazG family protein
PF1751_RS20145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF1751_RS20150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF1751_RS20190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF1751_RS20195	COG0583	DNA-binding transcription factor activity
PF1751_RS20205	COG1953	Uracil, thiamine, allantoin
PF1751_RS20215	COG2996	Protein conserved in bacteria
PF1751_RS20265	COG0513	Belongs to the DEAD box helicase family
PF1751_RS20270	COG0668	transmembrane transport
PF1751_RS20280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF1751_RS20305	COG1132	(ABC) transporter
PF1751_RS20310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PF1751_RS20320	COG2188	Transcriptional regulator
PF1751_RS20330	COG1595	DNA-templated transcription, initiation
PF1751_RS20340	COG1643	Atp-dependent helicase
PF1751_RS20345	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PF1751_RS20385	COG2076	Multidrug Resistance protein
PF1751_RS20390	COG0529	Catalyzes the synthesis of activated sulfate
PF1751_RS20445	COG0840	transmembrane signaling receptor activity
PF1751_RS20455	COG3278	Belongs to the heme-copper respiratory oxidase family
PF1751_RS20475	COG3278	Belongs to the heme-copper respiratory oxidase family
PF1751_RS20490	COG2010	Cytochrome c
PF1751_RS20505	COG0348	domain, Protein
PF1751_RS20540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF1751_RS20545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF1751_RS20550	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS20555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF1751_RS20560	COG2130	NADP-dependent
PF1751_RS20565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PF1751_RS20570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF1751_RS20585	COG0583	DNA-binding transcription factor activity
PF1751_RS20615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PF1751_RS20620	COG3115	cell septum assembly
PF1751_RS20640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF1751_RS20650	COG0402	S-adenosylhomocysteine deaminase activity
PF1751_RS20655	COG1802	Transcriptional regulator
PF1751_RS20660	COG3135	benzoate transporter
PF1751_RS20665	COG3171	Protein conserved in bacteria
PF1751_RS20680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF1751_RS20680	COG0116	Belongs to the methyltransferase superfamily
PF1751_RS20685	COG0167	dihydroorotate dehydrogenase activity
PF1751_RS20700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF1751_RS20710	COG1116	anion transmembrane transporter activity
PF1751_RS20710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS20715	COG3707	response regulator
PF1751_RS20720	COG2223	nitrite transmembrane transporter activity
PF1751_RS20730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF1751_RS20735	COG2885	chlorophyll binding
PF1751_RS20735	COG3047	cAMP biosynthetic process
PF1751_RS20760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PF1751_RS20775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PF1751_RS20780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS20795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF1751_RS20800	COG1045	serine acetyltransferase
PF1751_RS20805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PF1751_RS20820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF1751_RS20825	COG0372	Belongs to the citrate synthase family
PF1751_RS20835	COG1802	Transcriptional regulator
PF1751_RS20840	COG4067	protein conserved in archaea
PF1751_RS20840	COG0189	ligase activity
PF1751_RS20850	COG0189	ligase activity
PF1751_RS20855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF1751_RS20870	COG0560	Phosphoserine phosphatase
PF1751_RS20880	COG1953	Uracil, thiamine, allantoin
PF1751_RS20890	COG0583	DNA-binding transcription factor activity
PF1751_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS20900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF1751_RS20970	COG0598	Magnesium transport protein CorA
PF1751_RS20975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF1751_RS20975	COG0519	Catalyzes the synthesis of GMP from XMP
PF1751_RS20980	COG1024	Enoyl-CoA hydratase
PF1751_RS20980	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF1751_RS20985	COG0183	Belongs to the thiolase family
PF1751_RS20995	COG1305	Transglutaminase-like
PF1751_RS21005	COG2308	Evidence 4 Homologs of previously reported genes of
PF1751_RS21035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS21040	COG2885	chlorophyll binding
PF1751_RS21070	COG2207	Transcriptional regulator
PF1751_RS21075	COG1064	alcohol dehydrogenase
PF1751_RS21080	COG1414	Transcriptional regulator
PF1751_RS21085	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF1751_RS21090	COG1129	ABC transporter
PF1751_RS21095	COG1879	ABC-type sugar transport system periplasmic component
PF1751_RS21100	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS21135	COG1397	ADP-ribosylglycohydrolase
PF1751_RS21140	COG2188	Transcriptional regulator
PF1751_RS21165	COG0084	hydrolase, TatD family'
PF1751_RS21175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF1751_RS21180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF1751_RS21190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF1751_RS21195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF1751_RS21210	COG0416	fatty acid biosynthetic process
PF1751_RS21215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PF1751_RS21220	COG1399	metal-binding, possibly nucleic acid-binding protein
PF1751_RS21225	COG0424	maF-like protein
PF1751_RS21230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PF1751_RS21230	COG0616	signal peptide processing
PF1751_RS21235	COG0546	phosphoglycolate phosphatase activity
PF1751_RS21245	COG1530	ribonuclease E activity
PF1751_RS21255	COG3608	succinylglutamate desuccinylase aspartoacylase
PF1751_RS21255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PF1751_RS21260	COG1301	dicarboxylic acid transport
PF1751_RS21265	COG1917	Cupin 2, conserved barrel domain protein
PF1751_RS21265	COG4977	sequence-specific DNA binding
PF1751_RS21285	COG2977	Belongs to the P-Pant transferase superfamily
PF1751_RS21290	COG2205	protein histidine kinase activity
PF1751_RS21295	COG0745	RESPONSE REGULATOR receiver
PF1751_RS21315	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PF1751_RS21320	COG1558	bacterial-type flagellum-dependent cell motility
PF1751_RS21325	COG1815	bacterial-type flagellum-dependent cell motility
PF1751_RS21330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF1751_RS21335	COG0835	chemotaxis
PF1751_RS21335	COG0784	Response regulator, receiver
PF1751_RS21355	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PF1751_RS21360	COG0477	Major facilitator Superfamily
PF1751_RS21385	COG2239	Acts as a magnesium transporter
PF1751_RS21405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PF1751_RS21410	COG0527	aspartate kinase activity
PF1751_RS21415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PF1751_RS21420	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
PF1751_RS21425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PF1751_RS21435	COG2988	succinylglutamate desuccinylase activity
PF1751_RS21445	COG3724	N-succinylarginine dihydrolase activity
PF1751_RS21450	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS21465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF1751_RS21500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS21505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF1751_RS21520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF1751_RS21535	COG0165	Argininosuccinate lyase
PF1751_RS21540	COG0765	amino acid transport
PF1751_RS21555	COG2814	Major facilitator Superfamily
PF1751_RS21570	COG0154	amidase activity
PF1751_RS21590	COG3706	GGDEF domain
PF1751_RS21610	COG0504	CTP synthase activity
PF1751_RS21615	COG2329	Antibiotic biosynthesis monooxygenase
PF1751_RS21625	COG0584	glycerophosphoryl diester phosphodiesterase
PF1751_RS21650	COG0306	phosphate transporter
PF1751_RS21655	COG1984	allophanate hydrolase subunit 2
PF1751_RS21665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PF1751_RS21675	COG0583	DNA-binding transcription factor activity
PF1751_RS21680	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS21690	COG0583	DNA-binding transcription factor activity
PF1751_RS21700	COG4941	Belongs to the sigma-70 factor family
PF1751_RS21710	COG3795	YCII-related domain
PF1751_RS21730	COG0436	Aminotransferase
PF1751_RS21740	COG3265	gluconokinase activity
PF1751_RS21745	COG1609	Transcriptional regulator
PF1751_RS21765	COG2271	Major facilitator Superfamily
PF1751_RS21795	COG0242	peptide deformylase activity
PF1751_RS21800	COG1295	ribonuclease BN
PF1751_RS21815	COG0318	PFAM AMP-dependent synthetase and ligase
PF1751_RS21820	COG0318	PFAM AMP-dependent synthetase and ligase
PF1751_RS21830	COG2030	dehydratase
PF1751_RS21840	COG3530	Putative quorum-sensing-regulated virulence factor
PF1751_RS21845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF1751_RS21850	COG0800	Aldolase
PF1751_RS21865	COG1737	Transcriptional regulator
PF1751_RS21870	COG0676	glucose-6-phosphate 1-epimerase activity
PF1751_RS21880	COG3842	ATPase activity
PF1751_RS21885	COG0395	ABC-type sugar transport system, permease component
PF1751_RS21890	COG1175	transmembrane transport
PF1751_RS21895	COG1653	transport
PF1751_RS21910	COG1088	dTDP-glucose 4,6-dehydratase activity
PF1751_RS21915	COG0583	DNA-binding transcription factor activity
PF1751_RS21930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF1751_RS21955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF1751_RS21985	COG1113	amino acid transport
PF1751_RS22010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF1751_RS22020	COG0009	L-threonylcarbamoyladenylate synthase
PF1751_RS22030	COG2917	probably involved in intracellular septation
PF1751_RS22035	COG2350	Protein conserved in bacteria
PF1751_RS22045	COG0745	RESPONSE REGULATOR receiver
PF1751_RS22055	COG0642	Histidine kinase
PF1751_RS22105	COG0509	glycine decarboxylation via glycine cleavage system
PF1751_RS22110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PF1751_RS22110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PF1751_RS22115	COG1760	l-serine dehydratase
PF1751_RS22120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PF1751_RS22125	COG1278	Cold shock
PF1751_RS22135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF1751_RS22150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF1751_RS22155	COG0602	queuosine metabolic process
PF1751_RS22160	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PF1751_RS22165	COG2885	chlorophyll binding
PF1751_RS22170	COG0823	Involved in the tonB-independent uptake of proteins
PF1751_RS22190	COG0824	Thioesterase
PF1751_RS22195	COG2255	four-way junction helicase activity
PF1751_RS22200	COG0632	four-way junction helicase activity
PF1751_RS22205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PF1751_RS22210	COG0217	transcriptional regulatory protein
PF1751_RS22215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PF1751_RS22230	COG0783	Belongs to the Dps family
PF1751_RS22240	COG2900	Belongs to the SlyX family
PF1751_RS22255	COG0668	transmembrane transport
PF1751_RS22260	COG1666	GTP binding
PF1751_RS22270	COG4191	Histidine kinase
PF1751_RS22270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS22275	COG2096	Adenosyltransferase
PF1751_RS22285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF1751_RS22290	COG0653	protein targeting
PF1751_RS22300	COG0433	COG0433 Predicted ATPase
PF1751_RS22320	COG2925	Exonuclease
PF1751_RS22345	COG0714	Associated with various cellular activities
PF1751_RS22365	COG0469	pyruvate kinase activity
PF1751_RS22370	COG1024	Enoyl-CoA hydratase
PF1751_RS22385	COG4191	Histidine kinase
PF1751_RS22395	COG0477	Major facilitator Superfamily
PF1751_RS22415	COG2207	Transcriptional regulator
PF1751_RS22450	COG3712	iron ion homeostasis
PF1751_RS22455	COG4771	TonB-dependent receptor
PF1751_RS22465	COG2832	Protein of unknown function (DUF454)
PF1751_RS22470	COG0840	transmembrane signaling receptor activity
PF1751_RS22495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS22500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF1751_RS22510	COG3642	lipopolysaccharide core region biosynthetic process
PF1751_RS22520	COG0642	Histidine kinase
PF1751_RS22530	COG0459	protein refolding
PF1751_RS22535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PF1751_RS22565	COG0442	prolyl-tRNA aminoacylation
PF1751_RS22575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF1751_RS22610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PF1751_RS22640	COG4974	Belongs to the 'phage' integrase family
PF1751_RS22645	COG1607	acyl-coa hydrolase
PF1751_RS22650	COG0335	large ribosomal subunit rRNA binding
PF1751_RS22655	COG0336	Belongs to the RNA methyltransferase TrmD family
PF1751_RS22660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF1751_RS22665	COG0228	four-way junction DNA binding
PF1751_RS22670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF1751_RS22680	COG4536	flavin adenine dinucleotide binding
PF1751_RS22685	COG0477	Major facilitator Superfamily
PF1751_RS22690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PF1751_RS22710	COG0494	nUDIX hydrolase
PF1751_RS22725	COG2188	Transcriptional regulator
PF1751_RS22730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PF1751_RS22735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF1751_RS22740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF1751_RS22740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF1751_RS22745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF1751_RS22745	COG1263	PTS System
PF1751_RS22745	COG2190	(PTS) system
PF1751_RS22760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF1751_RS22765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF1751_RS22765	COG0047	phosphoribosylformylglycinamidine synthase activity
PF1751_RS22770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PF1751_RS22780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF1751_RS22780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF1751_RS22785	COG4580	involved in the transport of maltose and maltodextrins
PF1751_RS22790	COG0366	Alpha amylase catalytic
PF1751_RS22795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF1751_RS22795	COG1263	PTS System
PF1751_RS22800	COG2188	Transcriptional regulator
PF1751_RS22815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF1751_RS22815	COG0519	Catalyzes the synthesis of GMP from XMP
PF1751_RS22835	COG0583	DNA-binding transcription factor activity
PF1751_RS22840	COG1570	exodeoxyribonuclease VII activity
PF1751_RS22845	COG0739	heme binding
PF1751_RS22855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF1751_RS22865	COG0436	Aminotransferase
PF1751_RS22870	COG1160	GTP binding
PF1751_RS22885	COG0124	histidyl-tRNA synthetase
PF1751_RS22890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PF1751_RS22895	COG1426	Protein conserved in bacteria
PF1751_RS22905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PF1751_RS22910	COG0105	UTP biosynthetic process
PF1751_RS22920	COG0633	Ferredoxin
PF1751_RS22925	COG0443	Heat shock 70 kDa protein
PF1751_RS22930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PF1751_RS22935	COG0316	Belongs to the HesB IscA family
PF1751_RS22945	COG1104	cysteine desulfurase activity
PF1751_RS22955	COG1045	serine acetyltransferase
PF1751_RS22970	COG3134	Outer membrane lipoprotein
PF1751_RS22985	COG1862	Preprotein translocase
PF1751_RS22990	COG0343	queuine tRNA-ribosyltransferase activity
PF1751_RS22995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PF1751_RS23030	COG1280	lysine exporter protein (LysE YggA)
PF1751_RS23060	COG4251	negative regulation of phosphorylation
PF1751_RS23080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS23085	COG0583	DNA-binding transcription factor activity
PF1751_RS23090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF1751_RS23100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PF1751_RS23105	COG0109	protoheme IX farnesyltransferase activity
PF1751_RS23115	COG1845	cytochrome c oxidase, subunit III
PF1751_RS23120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF1751_RS23125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF1751_RS23130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF1751_RS23135	COG1017	nitric oxide dioxygenase activity
PF1751_RS23135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF1751_RS23140	COG3604	Transcriptional regulator
PF1751_RS23150	COG3708	Transcriptional regulator
PF1751_RS23150	COG2207	Transcriptional regulator
PF1751_RS23155	COG2909	trisaccharide binding
PF1751_RS23170	COG1028	Short-chain dehydrogenase reductase Sdr
PF1751_RS23175	COG0596	Alpha beta hydrolase
PF1751_RS23185	COG1346	cytolysis
PF1751_RS23190	COG1380	Effector of murein hydrolase LrgA
PF1751_RS23195	COG0583	DNA-binding transcription factor activity
PF1751_RS23205	COG1366	Belongs to the anti-sigma-factor antagonist family
PF1751_RS23215	COG0789	Transcriptional regulator
PF1751_RS23230	COG0302	gtp cyclohydrolase
PF1751_RS23235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF1751_RS23250	COG0492	ferredoxin-NADP+ reductase activity
PF1751_RS23255	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PF1751_RS23270	COG0386	Belongs to the glutathione peroxidase family
PF1751_RS23275	COG3045	CreA protein
PF1751_RS23280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF1751_RS23285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PF1751_RS23290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PF1751_RS23295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PF1751_RS23300	COG0142	geranyltranstransferase activity
PF1751_RS23305	COG2824	Alkylphosphonate utilization operon protein PhnA
PF1751_RS23310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PF1751_RS23315	COG0545	Peptidyl-prolyl cis-trans isomerase
PF1751_RS23320	COG0840	transmembrane signaling receptor activity
PF1751_RS23330	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PF1751_RS23340	COG2610	gluconate transmembrane transporter activity
PF1751_RS23350	COG0659	secondary active sulfate transmembrane transporter activity
PF1751_RS23360	COG0583	DNA-binding transcription factor activity
PF1751_RS23365	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF1751_RS23380	COG1113	amino acid transport
PF1751_RS23390	COG1522	sequence-specific DNA binding
PF1751_RS23395	COG3485	protocatechuate 3,4-dioxygenase
PF1751_RS23400	COG4829	muconolactone delta-isomerase
PF1751_RS23405	COG4948	Mandelate Racemase Muconate Lactonizing
PF1751_RS23420	COG4638	Rieske (2fe-2S)
PF1751_RS23425	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PF1751_RS23430	COG0543	2 iron, 2 sulfur cluster binding
PF1751_RS23430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF1751_RS23435	COG1113	amino acid transport
PF1751_RS23440	COG3483	tryptophan 2,3-dioxygenase activity
PF1751_RS23445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PF1751_RS23475	COG0583	DNA-binding transcription factor activity
PF1751_RS23505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF1751_RS23510	COG1074	ATP-dependent DNA helicase activity
PF1751_RS23515	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PF1751_RS23545	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PF1751_RS23550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF1751_RS23555	COG1183	phosphatidylcholine synthase activity
PF1751_RS23560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PF1751_RS23570	COG0028	Belongs to the TPP enzyme family
PF1751_RS23575	COG3098	single-species biofilm formation
PF1751_RS23585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF1751_RS23605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PF1751_RS23610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF1751_RS23615	COG4558	Periplasmic binding protein
PF1751_RS23625	COG1489	DNA binding
PF1751_RS23630	COG0436	Aminotransferase
PF1751_RS23640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF1751_RS23650	COG4191	Histidine kinase
PF1751_RS23670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PF1751_RS23675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PF1751_RS23680	COG0166	Belongs to the GPI family
PF1751_RS23685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF1751_RS23695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF1751_RS23705	COG2823	Periplasmic or secreted lipoprotein
PF1751_RS23710	COG1185	polyribonucleotide nucleotidyltransferase activity
PF1751_RS23715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PF1751_RS23720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF1751_RS23725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PF1751_RS23730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PF1751_RS23735	COG0195	Participates in both transcription termination and antitermination
PF1751_RS23740	COG0779	Required for maturation of 30S ribosomal subunits
PF1751_RS23755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF1751_RS23760	COG0149	triose-phosphate isomerase activity
PF1751_RS23765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF1751_RS23770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF1751_RS23780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PF1751_RS23795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF1751_RS23800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF1751_RS23805	COG0505	Belongs to the CarA family
PF1751_RS23810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PF1751_RS23815	COG0484	heat shock protein binding
PF1751_RS23820	COG0443	Heat shock 70 kDa protein
PF1751_RS23825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PF1751_RS23830	COG0497	DNA recombination
PF1751_RS23835	COG0735	belongs to the Fur family
PF1751_RS23840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF1751_RS23845	COG2914	Belongs to the UPF0125 (RnfH) family
PF1751_RS23855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PF1751_RS23860	COG2186	Transcriptional regulator
PF1751_RS23865	COG1620	l-lactate permease
PF1751_RS23930	COG2862	Uncharacterized protein family, UPF0114
PF1751_RS23945	COG1067	ATP-dependent peptidase activity
PF1751_RS23970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF1751_RS23980	COG0488	(ABC) transporter
PF1751_RS23995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PF1751_RS24000	COG0523	cobalamin synthesis protein
PF1751_RS24005	COG2879	small protein
PF1751_RS24010	COG1966	Carbon starvation protein
PF1751_RS24035	COG1970	mechanosensitive ion channel activity
PF1751_RS24045	COG2197	response regulator
PF1751_RS24050	COG2813	Specifically methylates the guanine in position
PF1751_RS24055	COG1294	oxidase, subunit
PF1751_RS24060	COG1271	oxidase subunit
PF1751_RS24070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF1751_RS24075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PF1751_RS24080	COG2080	2 iron, 2 sulfur cluster binding
PF1751_RS24090	COG2252	PERMEase
PF1751_RS24095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF1751_RS24135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PF1751_RS24140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF1751_RS24145	COG1309	transcriptional regulator
PF1751_RS24150	COG3185	4-Hydroxyphenylpyruvate dioxygenase
PF1751_RS24150	COG1082	Xylose isomerase domain protein TIM barrel
PF1751_RS24155	COG0477	Major facilitator Superfamily
PF1751_RS24170	COG2321	neutral zinc metallopeptidase
PF1751_RS24185	COG1946	Acyl-CoA thioesterase
PF1751_RS24195	COG0123	including yeast histone deacetylase and acetoin utilization protein
PF1751_RS24205	COG0513	Belongs to the DEAD box helicase family
PF1751_RS24210	COG0697	spore germination
PF1751_RS24215	COG1522	sequence-specific DNA binding
PF1751_RS24225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF1751_RS24225	COG1199	ATP-dependent helicase activity
PF1751_RS24235	COG3416	Protein conserved in bacteria
PF1751_RS24260	COG1643	Atp-dependent helicase
PF1751_RS24270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF1751_RS24280	COG1522	sequence-specific DNA binding
PF1751_RS24295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF1751_RS24300	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS24315	COG0352	thiamine-phosphate diphosphorylase activity
PF1751_RS24320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PF1751_RS24335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF1751_RS24340	COG1702	phosphate starvation-inducible protein PhoH
PF1751_RS24345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PF1751_RS24350	COG4535	Mg2 and Co2 transporter CorC
PF1751_RS24355	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PF1751_RS24370	COG0495	leucyl-tRNA aminoacylation
PF1751_RS24380	COG1466	dna polymerase III delta subunit
PF1751_RS24390	COG2951	lytic endotransglycosylase activity
PF1751_RS24400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF1751_RS24405	COG0321	lipoyl(octanoyl) transferase activity
PF1751_RS24410	COG2921	Belongs to the UPF0250 family
PF1751_RS24415	COG1686	Belongs to the peptidase S11 family
PF1751_RS24425	COG2951	lytic endotransglycosylase activity
PF1751_RS24430	COG0772	Belongs to the SEDS family
PF1751_RS24435	COG0768	penicillin binding
PF1751_RS24440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PF1751_RS24450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PF1751_RS24455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PF1751_RS24460	COG2094	Belongs to the DNA glycosylase MPG family
PF1751_RS24465	COG0586	Pfam SNARE associated Golgi protein
PF1751_RS24475	COG1346	cytolysis
PF1751_RS24480	COG1380	Effector of murein hydrolase LrgA
PF1751_RS24495	COG0702	epimerase
PF1751_RS24510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF1751_RS24515	COG3284	Transcriptional regulator
PF1751_RS24525	COG0531	amino acid
PF1751_RS24530	COG4303	Ethanolamine ammonia lyase large subunit
PF1751_RS24535	COG4302	ethanolamine ammonia-lyase activity
PF1751_RS24540	COG0456	acetyltransferase
PF1751_RS24545	COG0586	Pfam SNARE associated Golgi protein
PF1751_RS24550	COG3228	Belongs to the MtfA family
PF1751_RS24555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PF1751_RS24590	COG2003	Belongs to the UPF0758 family
PF1751_RS24630	COG1335	isochorismatase
PF1751_RS24645	COG1722	exodeoxyribonuclease VII activity
PF1751_RS24650	COG0142	geranyltranstransferase activity
PF1751_RS24655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PF1751_RS24660	COG4206	TonB-dependent receptor
PF1751_RS24665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF1751_RS24675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF1751_RS24685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF1751_RS24690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF1751_RS24695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PF1751_RS24710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF1751_RS24710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF1751_RS24715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PF1751_RS24725	COG2264	protein methyltransferase activity
PF1751_RS24730	COG3118	belongs to the thioredoxin family
PF1751_RS24745	COG4181	ATPase activity
PF1751_RS24770	COG0668	transmembrane transport
PF1751_RS24775	COG3568	Endonuclease Exonuclease Phosphatase
PF1751_RS24780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF1751_RS24785	COG0392	lysyltransferase activity
PF1751_RS24805	COG1335	isochorismatase
PF1751_RS24810	COG4106	trans-aconitate 2-methyltransferase activity
PF1751_RS24825	COG0629	single-stranded DNA binding
PF1751_RS24830	COG2814	Major facilitator Superfamily
PF1751_RS24835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF1751_RS24840	COG2193	ferroxidase activity
PF1751_RS24850	COG0203	ribosomal protein L17
PF1751_RS24855	COG0202	RNA polymerase activity
PF1751_RS24860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PF1751_RS24865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PF1751_RS24870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PF1751_RS24880	COG0200	Binds to the 23S rRNA
PF1751_RS24885	COG1841	ribosomal large subunit assembly
PF1751_RS24890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PF1751_RS24895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PF1751_RS24900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PF1751_RS24905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PF1751_RS24910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PF1751_RS24915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PF1751_RS24920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PF1751_RS24925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PF1751_RS24930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PF1751_RS24935	COG0255	Belongs to the universal ribosomal protein uL29 family
PF1751_RS24940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PF1751_RS24945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PF1751_RS24950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PF1751_RS24955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PF1751_RS24960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PF1751_RS24965	COG0089	rRNA binding
PF1751_RS24970	COG0088	Forms part of the polypeptide exit tunnel
PF1751_RS24975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PF1751_RS24980	COG0051	transcription antitermination factor activity, RNA binding
PF1751_RS24985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PF1751_RS24990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PF1751_RS24995	COG0049	tRNA binding
PF1751_RS25000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PF1751_RS25005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PF1751_RS25010	COG0085	RNA polymerase activity
PF1751_RS25015	COG0222	ribosome binding
PF1751_RS25020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PF1751_RS25025	COG0081	regulation of translation
PF1751_RS25030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PF1751_RS25070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PF1751_RS25105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF1751_RS25110	COG0739	heme binding
PF1751_RS25115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PF1751_RS25120	COG0316	Belongs to the HesB IscA family
PF1751_RS25125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PF1751_RS25130	COG1981	membrane
PF1751_RS25150	COG0537	adenosine 5'-monophosphoramidase activity
PF1751_RS25155	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PF1751_RS25160	COG1765	OsmC-like protein
PF1751_RS25175	COG0134	indole-3-glycerol-phosphate synthase activity
PF1751_RS25180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF1751_RS25185	COG0512	Glutamine amidotransferase of anthranilate synthase
PF1751_RS25190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF1751_RS25195	COG0546	phosphoglycolate phosphatase activity
PF1751_RS25200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF1751_RS25205	COG1454	alcohol dehydrogenase
PF1751_RS25215	COG1176	ABC-type spermidine putrescine transport system, permease component I
PF1751_RS25225	COG3842	ATPase activity
PF1751_RS25230	COG2197	response regulator
PF1751_RS25245	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PF1751_RS25250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF1751_RS25255	COG3178	'Phosphotransferase
PF1751_RS25260	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PF1751_RS25265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF1751_RS25270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PF1751_RS25275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF1751_RS25280	COG2967	ApaG domain
PF1751_RS25285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF1751_RS25290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF1751_RS25295	COG2766	serine protein kinase
PF1751_RS25300	COG2718	Belongs to the UPF0229 family
PF1751_RS25305	COG2719	SpoVR family
PF1751_RS25310	COG0617	tRNA 3'-terminal CCA addition
PF1751_RS25320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF1751_RS25325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PF1751_RS25330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PF1751_RS25340	COG0358	DNA primase activity
PF1751_RS25345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PF1751_RS25365	COG0583	DNA-binding transcription factor activity
PF1751_RS25380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF1751_RS25385	COG1025	Belongs to the peptidase M16 family
PF1751_RS25390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PF1751_RS25395	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PF1751_RS25405	COG0535	radical SAM domain protein
PF1751_RS25415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF1751_RS25420	COG0583	DNA-binding transcription factor activity
PF1751_RS25425	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS25430	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS25440	COG1960	acyl-CoA dehydrogenase activity
PF1751_RS25460	COG2226	methyltransferase
PF1751_RS25460	COG1073	alpha beta
PF1751_RS25465	COG0156	8-amino-7-oxononanoate synthase activity
PF1751_RS25470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PF1751_RS25480	COG3585	molybdate ion transport
PF1751_RS25480	COG2005	Transcriptional regulator
PF1751_RS25490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF1751_RS25505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PF1751_RS25515	COG3279	Response regulator of the LytR AlgR family
PF1751_RS25530	COG1595	DNA-templated transcription, initiation
PF1751_RS25545	COG4774	siderophore transport
PF1751_RS25555	COG2423	ornithine cyclodeaminase activity
PF1751_RS25560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS25575	COG1126	abc transporter atp-binding protein
PF1751_RS25580	COG2964	Protein conserved in bacteria
PF1751_RS25590	COG4452	Inner membrane protein CreD
PF1751_RS25595	COG2205	protein histidine kinase activity
PF1751_RS25600	COG0745	RESPONSE REGULATOR receiver
PF1751_RS25605	COG4067	protein conserved in archaea
PF1751_RS25605	COG0189	ligase activity
PF1751_RS25610	COG0204	Acyl-transferase
PF1751_RS25625	COG1063	alcohol dehydrogenase
PF1751_RS25655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PF1751_RS25675	COG1017	nitric oxide dioxygenase activity
PF1751_RS25675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF1751_RS25680	COG4638	Rieske (2fe-2S)
PF1751_RS25690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PF1751_RS25695	COG2181	nitrate reductase activity
PF1751_RS25695	COG0247	lactate metabolic process
PF1751_RS25700	COG1902	pentaerythritol trinitrate reductase activity
PF1751_RS25700	COG0446	pyridine nucleotide-disulphide oxidoreductase
PF1751_RS25740	COG3246	L-lysine catabolic process to acetate
PF1751_RS25745	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF1751_RS25770	COG1760	l-serine dehydratase
PF1751_RS25780	COG4176	ABC-type proline glycine betaine transport system permease component
PF1751_RS25785	COG4175	Glycine betaine
PF1751_RS25790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF1751_RS25795	COG1309	transcriptional regulator
PF1751_RS25800	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS25805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PF1751_RS25825	COG0477	Major facilitator Superfamily
PF1751_RS25830	COG0513	Belongs to the DEAD box helicase family
PF1751_RS25835	COG2081	HI0933 family
PF1751_RS25840	COG1289	transmembrane transporter activity
PF1751_RS25850	COG2153	protein acetylation
PF1751_RS25860	COG1451	nucleotide metabolic process
PF1751_RS25890	COG0126	phosphoglycerate kinase activity
PF1751_RS25895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF1751_RS25900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF1751_RS25905	COG0640	Transcriptional regulator
PF1751_RS25910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PF1751_RS25920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PF1751_RS25925	COG1422	Protein of unknown function (DUF1090)
PF1751_RS25950	COG2116	formate transmembrane transporter activity
PF1751_RS25965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PF1751_RS25970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF1751_RS25985	COG0513	Belongs to the DEAD box helicase family
PF1751_RS25990	COG2353	YceI-like domain
PF1751_RS25995	COG3038	cytochrome b561
PF1751_RS26005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF1751_RS26030	COG1272	protein, Hemolysin III
PF1751_RS26050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF1751_RS26070	COG3052	prosthetic group binding
PF1751_RS26075	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PF1751_RS26090	COG2198	Histidine kinase
PF1751_RS26090	COG0784	Response regulator, receiver
PF1751_RS26090	COG0643	Histidine kinase
PF1751_RS26115	COG0189	ligase activity
PF1751_RS26125	COG1678	Uncharacterized ACR, COG1678
PF1751_RS26130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF1751_RS26135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PF1751_RS26140	COG0540	Belongs to the ATCase OTCase family
PF1751_RS26145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF1751_RS26155	COG0791	NLP P60 protein
PF1751_RS26180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF1751_RS26185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PF1751_RS26185	COG2813	Specifically methylates the guanine in position
PF1751_RS26195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PF1751_RS26200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF1751_RS26210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF1751_RS26215	COG2022	thiamine diphosphate biosynthetic process
PF1751_RS26225	COG2363	Small membrane protein
PF1751_RS26230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF1751_RS26240	COG2177	Part of the ABC transporter FtsEX involved in
PF1751_RS26245	COG2884	Cell division ATP-binding protein ftsE
PF1751_RS26250	COG0552	protein localization to endoplasmic reticulum
PF1751_RS26255	COG0612	Peptidase, M16
PF1751_RS26260	COG0612	Peptidase, M16
PF1751_RS26265	COG0742	ribosomal rna small subunit methyltransferase
PF1751_RS26270	COG0429	hydrolase of the alpha beta-hydrolase fold
PF1751_RS26280	COG1309	transcriptional regulator
PF1751_RS26295	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PF1751_RS26300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PF1751_RS26305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PF1751_RS26310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PF1751_RS26320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF1751_RS26325	COG2814	Major facilitator Superfamily
PF1751_RS26330	COG0129	dihydroxy-acid dehydratase activity
PF1751_RS26340	COG1823	symporter activity
PF1751_RS26355	COG1160	GTP binding
PF1751_RS26375	COG1840	ABC-type Fe3 transport system, periplasmic component
PF1751_RS26380	COG1178	ABC-type Fe3 transport system permease component
PF1751_RS26385	COG3842	ATPase activity
PF1751_RS26390	COG0583	DNA-binding transcription factor activity
PF1751_RS26400	COG0789	Transcriptional regulator
PF1751_RS26405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF1751_RS26410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PF1751_RS26415	COG0730	response to heat
PF1751_RS26430	COG0494	nUDIX hydrolase
PF1751_RS26450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF1751_RS26455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PF1751_RS26460	COG3204	pilus organization
PF1751_RS26465	COG3204	pilus organization
PF1751_RS26470	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF1751_RS26475	COG0277	FAD linked oxidase domain protein
PF1751_RS26480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF1751_RS26490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS26495	COG1683	Conserved Protein
PF1751_RS26525	COG1917	Cupin 2, conserved barrel domain protein
PF1751_RS26525	COG4977	sequence-specific DNA binding
PF1751_RS26530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF1751_RS26545	COG1177	transmembrane transport
PF1751_RS26550	COG1176	ABC-type spermidine putrescine transport system, permease component I
PF1751_RS26555	COG3842	ATPase activity
PF1751_RS26575	COG0174	glutamine synthetase
PF1751_RS26580	COG0174	glutamine synthetase
PF1751_RS26595	COG1116	anion transmembrane transporter activity
PF1751_RS26600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF1751_RS26605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF1751_RS26610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF1751_RS26615	COG0431	NADPH-dependent FMN reductase
PF1751_RS26620	COG0450	alkyl hydroperoxide reductase
PF1751_RS26630	COG4521	taurine ABC transporter
PF1751_RS26635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PF1751_RS26635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PF1751_RS26650	COG1522	sequence-specific DNA binding
PF1751_RS26660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF1751_RS26665	COG0330	HflC and HflK could
PF1751_RS26685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF1751_RS26690	COG0509	glycine decarboxylation via glycine cleavage system
PF1751_RS26695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PF1751_RS26700	COG1178	ABC-type Fe3 transport system permease component
PF1751_RS26710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF1751_RS26720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF1751_RS26725	COG0006	proline dipeptidase activity
PF1751_RS26730	COG3079	Belongs to the UPF0149 family
PF1751_RS26745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF1751_RS26755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF1751_RS26760	COG0842	Transport permease protein
PF1751_RS26760	COG1129	ABC transporter
PF1751_RS26765	COG0842	Transport permease protein
PF1751_RS26780	COG2271	Major facilitator Superfamily
PF1751_RS26800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PF1751_RS26815	COG2186	Transcriptional regulator
PF1751_RS26820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS26825	COG0765	amino acid transport
PF1751_RS26830	COG0765	amino acid transport
PF1751_RS26835	COG1126	abc transporter atp-binding protein
PF1751_RS26845	COG3188	usher protein
PF1751_RS26850	COG3121	Chaperone
PF1751_RS26860	COG0248	Ppx GppA phosphatase
PF1751_RS26870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PF1751_RS26880	COG0586	Pfam SNARE associated Golgi protein
PF1751_RS26890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PF1751_RS26895	COG1671	Belongs to the UPF0178 family
PF1751_RS26900	COG0672	)-iron permease
PF1751_RS26915	COG0488	(ABC) transporter
PF1751_RS26945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF1751_RS26965	COG0181	hydroxymethylbilane synthase activity
PF1751_RS26975	COG0165	Argininosuccinate lyase
PF1751_RS26980	COG0625	glutathione transferase activity
PF1751_RS27000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF1751_RS27005	COG1965	Belongs to the frataxin family
PF1751_RS27015	COG0019	diaminopimelate decarboxylase activity
PF1751_RS27020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PF1751_RS27030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PF1751_RS27035	COG1011	Hydrolase
PF1751_RS27045	COG0432	Pfam Uncharacterised protein family UPF0047
PF1751_RS27050	COG0004	ammonium transporteR
PF1751_RS27055	COG0347	Belongs to the P(II) protein family
PF1751_RS27090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF1751_RS27110	COG0840	transmembrane signaling receptor activity
PF1751_RS27115	COG0583	DNA-binding transcription factor activity
PF1751_RS27120	COG0534	Mate efflux family protein
PF1751_RS27135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF1751_RS27140	COG0427	acetyl-CoA hydrolase
PF1751_RS27155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF1751_RS27160	COG0251	oxidation-reduction process
PF1751_RS27165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS27180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF1751_RS27190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF1751_RS27195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF1751_RS27205	COG1012	belongs to the aldehyde dehydrogenase family
PF1751_RS27215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PF1751_RS27220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PF1751_RS27225	COG0747	negative chemotaxis
PF1751_RS27230	COG2003	Belongs to the UPF0758 family
PF1751_RS27235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF1751_RS27240	COG0756	dUTP diphosphatase activity
PF1751_RS27245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF1751_RS27250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PF1751_RS27255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PF1751_RS27260	COG0708	Exodeoxyribonuclease III
PF1751_RS27270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PF1751_RS27275	COG1561	YicC-like family, N-terminal region
PF1751_RS27280	COG0194	GDP metabolic process
PF1751_RS27285	COG1758	RNA polymerase activity
PF1751_RS27290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF1751_RS27315	COG0848	biopolymer transport protein
PF1751_RS27325	COG0583	DNA-binding transcription factor activity
PF1751_RS27330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF1751_RS27360	COG1136	(ABC) transporter
PF1751_RS27365	COG0515	serine threonine protein kinase
PF1751_RS27365	COG2815	serine threonine protein kinase
PF1751_RS27370	COG0631	protein serine/threonine phosphatase activity
PF1751_RS27480	COG3161	chorismate lyase activity
PF1751_RS27485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PF1751_RS27505	COG1253	flavin adenine dinucleotide binding
PF1751_RS27510	COG0739	heme binding
PF1751_RS27520	COG0704	Plays a role in the regulation of phosphate uptake
PF1751_RS27525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF1751_RS27530	COG0573	inorganic phosphate transmembrane transporter activity
PF1751_RS27545	COG0477	Major facilitator Superfamily
PF1751_RS27550	COG1607	acyl-coa hydrolase
PF1751_RS27580	COG0583	DNA-binding transcription factor activity
PF1751_RS27585	COG1027	Aspartate ammonia-lyase
PF1751_RS27590	COG1115	amino acid carrier protein
PF1751_RS27595	COG0252	asparaginase activity
PF1751_RS27625	COG2808	Putative FMN-binding domain
PF1751_RS27645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF1751_RS27650	COG0765	amino acid transport
PF1751_RS27665	COG0511	ligase activity, forming carbon-carbon bonds
PF1751_RS27665	COG5016	pyruvate
PF1751_RS27670	COG0439	Biotin carboxylase
PF1751_RS27675	COG0583	DNA-binding transcription factor activity
PF1751_RS27690	COG3300	MHYT domain
PF1751_RS27690	COG5001	Diguanylate cyclase
PF1751_RS27695	COG0210	DNA helicase
PF1751_RS27710	COG4651	solute:proton antiporter activity
PF1751_RS27710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF1751_RS27715	COG1607	acyl-coa hydrolase
PF1751_RS27720	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PF1751_RS27730	COG0523	cobalamin synthesis protein
PF1751_RS27755	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF1751_RS27760	COG1469	GTP cyclohydrolase I activity
PF1751_RS27765	COG1121	(ABC) transporter
PF1751_RS27780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF1751_RS27790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF1751_RS27800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF1751_RS27805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PF1751_RS27815	COG3220	belongs to the UPF0276 family
PF1751_RS27845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF1751_RS27850	COG2267	carboxylic ester hydrolase activity
PF1751_RS27855	COG0671	phosphoesterase, PA-phosphatase related
PF1751_RS27855	COG2453	phosphatase
PF1751_RS27870	COG4589	Belongs to the CDS family
PF1751_RS27875	COG1522	sequence-specific DNA binding
PF1751_RS27880	COG1280	lysine exporter protein (LysE YggA)
PF1751_RS27885	COG2373	Large extracellular alpha-helical protein
PF1751_RS27890	COG4953	penicillin-binding protein 1C
PF1751_RS27900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF1751_RS27905	COG1349	DNA-binding transcription factor activity
PF1751_RS27910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PF1751_RS27915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PF1751_RS27920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PF1751_RS27925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PF1751_RS27930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PF1751_RS27935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PF1751_RS27940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PF1751_RS27950	COG0356	it plays a direct role in the translocation of protons across the membrane
PF1751_RS27955	COG3312	ion transport
PF1751_RS27960	COG1475	DNA binding
PF1751_RS27965	COG1192	Involved in chromosome partitioning
PF1751_RS27970	COG0357	Ribosomal RNA small subunit methyltransferase G
PF1751_RS27975	COG0445	tRNA wobble uridine modification
PF1751_RS27980	COG1595	DNA-templated transcription, initiation
PF1751_RS27985	COG3712	iron ion homeostasis
PF1751_RS27990	COG4774	siderophore transport
PF1751_RS27995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PF1751_RS28000	COG0706	membrane insertase activity
PF1751_RS28010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PF1751_RS28090	COG5487	UPF0391 membrane protein
PF1751_RS28220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF1751_RS28365	COG0588	phosphoglycerate mutase activity
PF1751_RS28400	COG1309	transcriptional regulator
PF1751_RS28470	COG3038	cytochrome b561
PF1751_RS28490	COG0456	acetyltransferase
PF1751_RS28540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PF1751_RS28565	COG3130	regulation of translation
PF1751_RS28650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PF1751_RS28660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PF1751_RS28745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PF1751_RS28750	COG0594	ribonuclease P activity