locus-tag	class	description
O165_RS00015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O165_RS00025	COG0583	DNA-binding transcription factor activity
O165_RS00030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O165_RS00055	COG1902	pentaerythritol trinitrate reductase activity
O165_RS00065	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
O165_RS00070	COG0204	Acyl-transferase
O165_RS00100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O165_RS00105	COG0693	protein deglycase activity
O165_RS00140	COG0469	pyruvate kinase activity
O165_RS00155	COG2925	Exonuclease
O165_RS00165	COG0788	formyltetrahydrofolate deformylase activity
O165_RS00180	COG0438	transferase activity, transferring glycosyl groups
O165_RS00180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O165_RS00185	COG0840	transmembrane signaling receptor activity
O165_RS00190	COG0433	COG0433 Predicted ATPase
O165_RS00195	COG0306	phosphate transporter
O165_RS00205	COG1414	Transcriptional regulator
O165_RS00210	COG2814	Major facilitator Superfamily
O165_RS00215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O165_RS00220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O165_RS00225	COG0183	Belongs to the thiolase family
O165_RS00230	COG0477	Major facilitator Superfamily
O165_RS00235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O165_RS00240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O165_RS00245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O165_RS00280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS00285	COG1309	transcriptional regulator
O165_RS00290	COG0477	Major facilitator Superfamily
O165_RS00295	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O165_RS00300	COG0583	DNA-binding transcription factor activity
O165_RS00310	COG2910	NAD(P)H-binding
O165_RS00315	COG0583	DNA-binding transcription factor activity
O165_RS00325	COG2207	Transcriptional regulator
O165_RS00355	COG0477	Major facilitator Superfamily
O165_RS00365	COG4191	Histidine kinase
O165_RS00390	COG1629	transport
O165_RS00410	COG0584	glycerophosphoryl diester phosphodiesterase
O165_RS00425	COG2267	carboxylic ester hydrolase activity
O165_RS00455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O165_RS00500	COG0354	folic acid binding
O165_RS00505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
O165_RS00515	COG2974	May be involved in recombination
O165_RS00530	COG0443	Heat shock 70 kDa protein
O165_RS00535	COG2214	Heat shock protein DnaJ domain protein
O165_RS00545	COG0583	DNA-binding transcription factor activity
O165_RS00550	COG2146	nitrite reductase [NAD(P)H] activity
O165_RS00550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O165_RS00555	COG2146	nitrite reductase [NAD(P)H] activity
O165_RS00555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O165_RS00560	COG0243	molybdopterin cofactor binding
O165_RS00570	COG0024	Methionine aminopeptidase
O165_RS00575	COG1902	pentaerythritol trinitrate reductase activity
O165_RS00585	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS00590	COG2979	Protein of unknown function (DUF533)
O165_RS00595	COG0840	transmembrane signaling receptor activity
O165_RS00605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O165_RS00605	COG0457	Tetratricopeptide repeat
O165_RS00620	COG2201	protein-glutamate methylesterase activity
O165_RS00625	COG2203	Gaf domain
O165_RS00625	COG3706	GGDEF domain
O165_RS00625	COG4251	negative regulation of phosphorylation
O165_RS00625	COG5001	Diguanylate cyclase
O165_RS00635	COG3339	Conserved Protein
O165_RS00650	COG2200	EAL domain
O165_RS00650	COG2199	diguanylate cyclase activity
O165_RS00685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O165_RS00690	COG0481	GTPase activity
O165_RS00695	COG0681	Belongs to the peptidase S26 family
O165_RS00700	COG0571	ribonuclease III activity
O165_RS00705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O165_RS00710	COG1381	Involved in DNA repair and RecF pathway recombination
O165_RS00715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O165_RS00735	COG0500	methyltransferase
O165_RS00740	COG2226	methyltransferase
O165_RS00750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O165_RS00765	COG4206	TonB-dependent receptor
O165_RS00770	COG4628	conserved protein (DUF2132)
O165_RS00780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O165_RS00785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O165_RS00895	COG3179	chitinase
O165_RS00905	COG1546	Belongs to the CinA family
O165_RS00910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O165_RS00915	COG2137	regulation of response to DNA damage stimulus
O165_RS00935	COG3148	PFAM DTW domain containing protein
O165_RS00950	COG0583	DNA-binding transcription factor activity
O165_RS00965	COG4807	Protein conserved in bacteria
O165_RS00980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O165_RS00985	COG3158	transport of potassium into the cell
O165_RS01015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O165_RS01025	COG0442	prolyl-tRNA aminoacylation
O165_RS01040	COG2900	Belongs to the SlyX family
O165_RS01050	COG0783	Belongs to the Dps family
O165_RS01065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O165_RS01070	COG0217	transcriptional regulatory protein
O165_RS01075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O165_RS01080	COG0632	four-way junction helicase activity
O165_RS01085	COG2255	four-way junction helicase activity
O165_RS01090	COG0824	Thioesterase
O165_RS01110	COG0823	Involved in the tonB-independent uptake of proteins
O165_RS01115	COG2885	chlorophyll binding
O165_RS01120	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
O165_RS01125	COG0602	queuosine metabolic process
O165_RS01130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O165_RS01140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O165_RS01160	COG3609	addiction module antidote protein, CC2985 family
O165_RS01275	COG1074	ATP-dependent DNA helicase activity
O165_RS01330	COG2135	peptidase activity
O165_RS01440	COG1917	Cupin 2, conserved barrel domain protein
O165_RS01440	COG2169	Transcriptional regulator
O165_RS01500	COG1238	metal cluster binding
O165_RS01520	COG2814	Major facilitator Superfamily
O165_RS01540	COG0642	Histidine kinase
O165_RS01550	COG3039	Transposase
O165_RS01595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O165_RS01605	COG0789	Transcriptional regulator
O165_RS01640	COG4644	lycopene metabolic process
O165_RS01705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O165_RS01715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O165_RS01760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O165_RS01785	COG3081	Nucleoid-associated protein
O165_RS01800	COG0305	Participates in initiation and elongation during chromosome replication
O165_RS01830	COG1366	Belongs to the anti-sigma-factor antagonist family
O165_RS01835	COG1366	Belongs to the anti-sigma-factor antagonist family
O165_RS01840	COG2172	sigma factor antagonist activity
O165_RS01850	COG2205	protein histidine kinase activity
O165_RS01855	COG4191	Histidine kinase
O165_RS01855	COG0784	Response regulator, receiver
O165_RS01865	COG0833	amino acid
O165_RS01870	COG2194	sulfuric ester hydrolase activity
O165_RS01875	COG0840	transmembrane signaling receptor activity
O165_RS01880	COG0531	amino acid
O165_RS01890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O165_RS01895	COG4783	chaperone-mediated protein folding
O165_RS01900	COG0425	Belongs to the sulfur carrier protein TusA family
O165_RS01910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O165_RS01920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O165_RS01925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
O165_RS01930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O165_RS01935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O165_RS01955	COG0579	oxidoreductase
O165_RS01960	COG0640	Transcriptional regulator
O165_RS01965	COG1902	pentaerythritol trinitrate reductase activity
O165_RS01970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS01980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O165_RS01985	COG3938	Belongs to the proline racemase family
O165_RS01990	COG0531	amino acid
O165_RS02000	COG0583	DNA-binding transcription factor activity
O165_RS02005	COG0521	Mo-molybdopterin cofactor biosynthetic process
O165_RS02010	COG3781	membrane
O165_RS02015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O165_RS02020	COG0243	molybdopterin cofactor binding
O165_RS02025	COG1522	sequence-specific DNA binding
O165_RS02030	COG0626	cystathionine gamma-synthase activity
O165_RS02045	COG2194	sulfuric ester hydrolase activity
O165_RS02055	COG3100	YcgL domain-containing protein
O165_RS02060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O165_RS02070	COG2983	Belongs to the UPF0260 family
O165_RS02125	COG0121	glutamine amidotransferase
O165_RS02140	COG2814	Major facilitator Superfamily
O165_RS02145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O165_RS02150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O165_RS02155	COG1984	allophanate hydrolase subunit 2
O165_RS02180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O165_RS02200	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
O165_RS02225	COG1295	ribonuclease BN
O165_RS02230	COG0242	peptide deformylase activity
O165_RS02245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS02275	COG3795	YCII-related domain
O165_RS02280	COG4941	Belongs to the sigma-70 factor family
O165_RS02285	COG2030	dehydratase
O165_RS02290	COG2267	carboxylic ester hydrolase activity
O165_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS02300	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS02305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS02310	COG0174	glutamine synthetase
O165_RS02315	COG1643	Atp-dependent helicase
O165_RS02325	COG2188	Transcriptional regulator
O165_RS02335	COG1132	(ABC) transporter
O165_RS02345	COG2267	carboxylic ester hydrolase activity
O165_RS02360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O165_RS02370	COG0583	DNA-binding transcription factor activity
O165_RS02375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O165_RS02395	COG0668	transmembrane transport
O165_RS02400	COG0513	Belongs to the DEAD box helicase family
O165_RS02425	COG0697	spore germination
O165_RS02435	COG0583	DNA-binding transcription factor activity
O165_RS02440	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
O165_RS02440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS02445	COG2326	polyphosphate kinase activity
O165_RS02450	COG0697	spore germination
O165_RS02455	COG0114	fumarate hydratase activity
O165_RS02465	COG0271	Belongs to the BolA IbaG family
O165_RS02470	COG1054	Belongs to the UPF0176 family
O165_RS02485	COG5001	Diguanylate cyclase
O165_RS02485	COG5002	protein histidine kinase activity
O165_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS02500	COG0546	phosphoglycolate phosphatase activity
O165_RS02505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O165_RS02510	COG0402	S-adenosylhomocysteine deaminase activity
O165_RS02515	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O165_RS02525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O165_RS02535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O165_RS02540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O165_RS02560	COG0776	regulation of translation
O165_RS02590	COG1086	Polysaccharide biosynthesis protein
O165_RS02605	COG0438	transferase activity, transferring glycosyl groups
O165_RS02610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O165_RS02615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O165_RS02625	COG2030	dehydratase
O165_RS02630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O165_RS02645	COG1091	dTDP-4-dehydrorhamnose reductase activity
O165_RS02655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O165_RS02675	COG1215	transferase activity, transferring glycosyl groups
O165_RS02685	COG0284	orotidine-5'-phosphate decarboxylase activity
O165_RS02695	COG1215	transferase activity, transferring glycosyl groups
O165_RS02715	COG1555	photosystem II stabilization
O165_RS02720	COG2130	NADP-dependent
O165_RS02730	COG2814	Major facilitator Superfamily
O165_RS02740	COG0840	transmembrane signaling receptor activity
O165_RS02745	COG3135	benzoate transporter
O165_RS02750	COG0625	glutathione transferase activity
O165_RS02760	COG0302	gtp cyclohydrolase
O165_RS02765	COG2840	Smr protein MutS2
O165_RS02795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O165_RS02800	COG2814	Major facilitator Superfamily
O165_RS02805	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O165_RS02835	COG1368	sulfuric ester hydrolase activity
O165_RS02855	COG0519	Catalyzes the synthesis of GMP from XMP
O165_RS02860	COG0598	Magnesium transport protein CorA
O165_RS02865	COG0204	Acyl-transferase
O165_RS02895	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
O165_RS02920	COG2814	Major facilitator Superfamily
O165_RS02925	COG0583	DNA-binding transcription factor activity
O165_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS02935	COG0583	DNA-binding transcription factor activity
O165_RS02955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O165_RS02960	COG1764	response to oxidative stress
O165_RS02965	COG1846	Transcriptional regulator
O165_RS02970	COG0583	DNA-binding transcription factor activity
O165_RS02980	COG0583	DNA-binding transcription factor activity
O165_RS02990	COG3214	Protein conserved in bacteria
O165_RS02995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
O165_RS03010	COG3384	dioxygenase
O165_RS03015	COG0500	methyltransferase
O165_RS03020	COG0501	Belongs to the peptidase M48B family
O165_RS03025	COG0436	Aminotransferase
O165_RS03030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O165_RS03035	COG0386	Belongs to the glutathione peroxidase family
O165_RS03040	COG3437	response regulator, receiver
O165_RS03040	COG4999	Histidine kinase
O165_RS03040	COG3850	Histidine kinase
O165_RS03040	COG2205	protein histidine kinase activity
O165_RS03050	COG1956	GAF domain-containing protein
O165_RS03080	COG0582	viral genome integration into host DNA
O165_RS03085	COG2837	iron assimilation
O165_RS03095	COG0583	DNA-binding transcription factor activity
O165_RS03160	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O165_RS03165	COG1252	NADH dehydrogenase
O165_RS03170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O165_RS03175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O165_RS03175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O165_RS03230	COG2003	Belongs to the UPF0758 family
O165_RS03435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O165_RS03440	COG0629	single-stranded DNA binding
O165_RS03520	COG0625	glutathione transferase activity
O165_RS03525	COG1131	(ABC) transporter
O165_RS03530	COG0842	Transport permease protein
O165_RS03540	COG0658	competence protein
O165_RS03540	COG2333	competence protein COMEC
O165_RS03550	COG0848	biopolymer transport protein
O165_RS03555	COG1663	tetraacyldisaccharide 4'-kinase activity
O165_RS03560	COG2835	tetraacyldisaccharide 4'-kinase activity
O165_RS03565	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
O165_RS03570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O165_RS03575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O165_RS03580	COG1530	ribonuclease E activity
O165_RS03590	COG0546	phosphoglycolate phosphatase activity
O165_RS03595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O165_RS03595	COG0616	signal peptide processing
O165_RS03600	COG0424	maF-like protein
O165_RS03610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O165_RS03615	COG0416	fatty acid biosynthetic process
O165_RS03630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O165_RS03635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O165_RS03645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O165_RS03650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O165_RS03660	COG0084	hydrolase, TatD family'
O165_RS03675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O165_RS03715	COG1953	Uracil, thiamine, allantoin
O165_RS03720	COG1522	sequence-specific DNA binding
O165_RS03730	COG2831	hemolysin activation secretion protein
O165_RS03770	COG0435	Glutathione S-transferase
O165_RS03775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O165_RS03785	COG1960	acyl-CoA dehydrogenase activity
O165_RS03795	COG0367	asparagine synthase
O165_RS03800	COG1024	Enoyl-CoA hydratase
O165_RS03805	COG3425	synthase
O165_RS03810	COG0583	DNA-binding transcription factor activity
O165_RS03825	COG1538	Outer membrane efflux protein
O165_RS03830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS03845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O165_RS03855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O165_RS03865	COG0469	pyruvate kinase activity
O165_RS03875	COG2084	Dehydrogenase
O165_RS03880	COG3622	Belongs to the hyi family
O165_RS03885	COG3960	tartronate-semialdehyde synthase activity
O165_RS03910	COG2354	Protein conserved in bacteria
O165_RS03925	COG2233	PERMEase
O165_RS03940	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
O165_RS03965	COG2252	PERMEase
O165_RS03975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O165_RS03980	COG0402	S-adenosylhomocysteine deaminase activity
O165_RS04010	COG3115	cell septum assembly
O165_RS04015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O165_RS04045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O165_RS04050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O165_RS04055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O165_RS04060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O165_RS04065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O165_RS04085	COG2217	Heavy metal translocating P-type atpase
O165_RS04095	COG0348	domain, Protein
O165_RS04100	COG2010	Cytochrome c
O165_RS04115	COG3278	Belongs to the heme-copper respiratory oxidase family
O165_RS04120	COG2010	Cytochrome c
O165_RS04135	COG3278	Belongs to the heme-copper respiratory oxidase family
O165_RS04145	COG3123	guanosine phosphorylase activity
O165_RS04175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O165_RS04190	COG0642	Histidine kinase
O165_RS04215	COG1136	(ABC) transporter
O165_RS04215	COG0577	efflux transmembrane transporter activity
O165_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS04230	COG2198	Histidine kinase
O165_RS04230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS04230	COG0784	Response regulator, receiver
O165_RS04230	COG2205	protein histidine kinase activity
O165_RS04265	COG2885	chlorophyll binding
O165_RS04270	COG2027	D-alanyl-D-alanine carboxypeptidase
O165_RS04275	COG3171	Protein conserved in bacteria
O165_RS04280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS04280	COG2205	protein histidine kinase activity
O165_RS04285	COG2197	response regulator
O165_RS04310	COG0004	ammonium transporteR
O165_RS04325	COG0564	pseudouridine synthase activity
O165_RS04330	COG0840	transmembrane signaling receptor activity
O165_RS04345	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
O165_RS04350	COG0425	Belongs to the sulfur carrier protein TusA family
O165_RS04355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O165_RS04385	COG0521	Mo-molybdopterin cofactor biosynthetic process
O165_RS04390	COG0303	'Molybdopterin
O165_RS04395	COG0438	transferase activity, transferring glycosyl groups
O165_RS04400	COG0662	Cupin 2, conserved barrel domain protein
O165_RS04400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
O165_RS04405	COG1597	lipid kinase activity
O165_RS04410	COG2197	response regulator
O165_RS04415	COG3851	Histidine kinase
O165_RS04435	COG0741	lytic transglycosylase activity
O165_RS04440	COG0488	(ABC) transporter
O165_RS04445	COG0589	response to stress
O165_RS04455	COG1024	Enoyl-CoA hydratase
O165_RS04455	COG1250	3-hydroxyacyl-CoA dehydrogenase
O165_RS04460	COG0183	Belongs to the thiolase family
O165_RS04490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O165_RS04505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O165_RS04515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O165_RS04525	COG1477	protein flavinylation
O165_RS04530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O165_RS04535	COG0584	glycerophosphoryl diester phosphodiesterase
O165_RS04545	COG4591	ABC-type transport system involved in lipoprotein release permease component
O165_RS04550	COG1136	(ABC) transporter
O165_RS04555	COG4591	ABC-type transport system involved in lipoprotein release permease component
O165_RS04575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O165_RS04575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O165_RS04590	COG2853	Lipoprotein
O165_RS04600	COG4566	intracellular signal transduction
O165_RS04615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O165_RS04620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O165_RS04695	COG2323	membrane
O165_RS04705	COG1058	Belongs to the CinA family
O165_RS04705	COG1546	Belongs to the CinA family
O165_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS04725	COG1063	alcohol dehydrogenase
O165_RS04775	COG0583	DNA-binding transcription factor activity
O165_RS04805	COG3766	membrane
O165_RS04815	COG0754	glutathionylspermidine amidase activity
O165_RS04830	COG3383	formate dehydrogenase (NAD+) activity
O165_RS04845	COG4178	(ABC) transporter
O165_RS04850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O165_RS04870	COG0745	RESPONSE REGULATOR receiver
O165_RS04875	COG4251	negative regulation of phosphorylation
O165_RS04915	COG2866	Carboxypeptidase
O165_RS04945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O165_RS04950	COG1960	acyl-CoA dehydrogenase activity
O165_RS04955	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS04960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O165_RS04970	COG0366	Alpha amylase catalytic
O165_RS04975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O165_RS04985	COG3568	Endonuclease Exonuclease Phosphatase
O165_RS05005	COG1640	4-alpha-glucanotransferase
O165_RS05010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O165_RS05015	COG0297	glycogen (starch) synthase activity
O165_RS05020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O165_RS05025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O165_RS05035	COG3387	PFAM Glycoside hydrolase 15-related
O165_RS05050	COG2271	Major facilitator Superfamily
O165_RS05080	COG2080	2 iron, 2 sulfur cluster binding
O165_RS05085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O165_RS05090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O165_RS05110	COG2080	2 iron, 2 sulfur cluster binding
O165_RS05135	COG2066	Belongs to the glutaminase family
O165_RS05160	COG1418	mRNA catabolic process
O165_RS05225	COG3132	Protein of unknown function, DUF480
O165_RS05230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O165_RS05235	COG0583	DNA-binding transcription factor activity
O165_RS05245	COG1253	flavin adenine dinucleotide binding
O165_RS05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS05375	COG0305	Participates in initiation and elongation during chromosome replication
O165_RS05435	COG4695	Portal protein
O165_RS05545	COG3179	chitinase
O165_RS05575	COG5001	Diguanylate cyclase
O165_RS05580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O165_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS05605	COG0616	signal peptide processing
O165_RS05660	COG0789	Transcriptional regulator
O165_RS05685	COG2259	Doxx family
O165_RS05705	COG4191	Histidine kinase
O165_RS05705	COG0784	Response regulator, receiver
O165_RS05710	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
O165_RS05715	COG0745	RESPONSE REGULATOR receiver
O165_RS05720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O165_RS05730	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
O165_RS05750	COG1953	Uracil, thiamine, allantoin
O165_RS05760	COG0493	'glutamate synthase
O165_RS05770	COG0583	DNA-binding transcription factor activity
O165_RS05825	COG0477	Major facilitator Superfamily
O165_RS05830	COG0583	DNA-binding transcription factor activity
O165_RS05835	COG1309	transcriptional regulator
O165_RS05865	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O165_RS05870	COG1024	Enoyl-CoA hydratase
O165_RS05875	COG2816	NAD+ diphosphatase activity
O165_RS05890	COG0730	response to heat
O165_RS05895	COG0174	glutamine synthetase
O165_RS05905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS05915	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
O165_RS05920	COG2153	protein acetylation
O165_RS05925	COG2850	peptidyl-arginine hydroxylation
O165_RS05935	COG2915	High frequency lysogenization protein hflD homolog
O165_RS05940	COG0482	sulfurtransferase activity
O165_RS05965	COG1278	Cold shock
O165_RS05970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O165_RS05975	COG0542	response to heat
O165_RS05980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O165_RS05985	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O165_RS05990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O165_RS05995	COG1674	ftsk spoiiie
O165_RS06000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O165_RS06005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O165_RS06010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O165_RS06015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O165_RS06020	COG1648	precorrin-2 dehydrogenase activity
O165_RS06020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O165_RS06025	COG0435	Glutathione S-transferase
O165_RS06030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O165_RS06035	COG2920	part of a sulfur-relay system
O165_RS06055	COG2233	PERMEase
O165_RS06090	COG0583	DNA-binding transcription factor activity
O165_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS06100	COG0456	acetyltransferase
O165_RS06130	COG2199	diguanylate cyclase activity
O165_RS06135	COG0490	domain, Protein
O165_RS06135	COG0471	metal ion transport
O165_RS06145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O165_RS06160	COG0488	(ABC) transporter
O165_RS06165	COG1278	Cold shock
O165_RS06175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O165_RS06180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O165_RS06185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O165_RS06190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O165_RS06195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O165_RS06200	COG0072	phenylalanine-tRNA ligase activity
O165_RS06205	COG0776	regulation of translation
O165_RS06320	COG1484	DNA-dependent DNA replication
O165_RS06375	COG1802	Transcriptional regulator
O165_RS06375	COG4626	Terminase
O165_RS06475	COG3179	chitinase
O165_RS06540	COG1070	Carbohydrate kinase
O165_RS06545	COG0246	Mannitol dehydrogenase
O165_RS06560	COG1175	transmembrane transport
O165_RS06590	COG2873	o-acetylhomoserine
O165_RS06600	COG1999	signal sequence binding
O165_RS06615	COG0583	DNA-binding transcription factor activity
O165_RS06620	COG0477	Major facilitator Superfamily
O165_RS06635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS06645	COG4106	trans-aconitate 2-methyltransferase activity
O165_RS06655	COG0583	DNA-binding transcription factor activity
O165_RS06660	COG2271	Major facilitator Superfamily
O165_RS06665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS06670	COG0217	transcriptional regulatory protein
O165_RS06675	COG0583	DNA-binding transcription factor activity
O165_RS06680	COG0076	glutamate decarboxylase activity
O165_RS06710	COG0625	glutathione transferase activity
O165_RS06720	COG0583	DNA-binding transcription factor activity
O165_RS06725	COG3300	MHYT domain
O165_RS06725	COG5001	Diguanylate cyclase
O165_RS06740	COG0477	Major facilitator Superfamily
O165_RS06745	COG1082	Xylose isomerase domain protein TIM barrel
O165_RS06745	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O165_RS06750	COG1309	transcriptional regulator
O165_RS06755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O165_RS06760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O165_RS06765	COG0579	oxidoreductase
O165_RS06780	COG3842	ATPase activity
O165_RS06785	COG1177	transmembrane transport
O165_RS06790	COG1176	ABC-type spermidine putrescine transport system, permease component I
O165_RS06800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O165_RS06810	COG0861	Integral membrane protein TerC family
O165_RS06860	COG0583	DNA-binding transcription factor activity
O165_RS06875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O165_RS06885	COG0019	diaminopimelate decarboxylase activity
O165_RS06895	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O165_RS06900	COG0477	Major facilitator Superfamily
O165_RS06920	COG3706	GGDEF domain
O165_RS06945	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O165_RS06950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O165_RS06965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O165_RS06975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O165_RS06985	COG0583	DNA-binding transcription factor activity
O165_RS07000	COG2010	Cytochrome c
O165_RS07005	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O165_RS07005	COG3608	succinylglutamate desuccinylase aspartoacylase
O165_RS07010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O165_RS07025	COG0604	alcohol dehydrogenase
O165_RS07025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O165_RS07025	COG4221	oxidoreductase activity
O165_RS07025	COG3321	synthase
O165_RS07030	COG0583	DNA-binding transcription factor activity
O165_RS07055	COG3469	chitinase activity
O165_RS07070	COG1595	DNA-templated transcription, initiation
O165_RS07075	COG3712	iron ion homeostasis
O165_RS07090	COG0625	glutathione transferase activity
O165_RS07100	COG1132	(ABC) transporter
O165_RS07110	COG0640	Transcriptional regulator
O165_RS07120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O165_RS07125	COG0431	NADPH-dependent FMN reductase
O165_RS07165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O165_RS07180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O165_RS07190	COG0436	Aminotransferase
O165_RS07220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O165_RS07225	COG0583	DNA-binding transcription factor activity
O165_RS07235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O165_RS07235	COG2890	protein-(glutamine-N5) methyltransferase activity
O165_RS07255	COG0604	alcohol dehydrogenase
O165_RS07255	COG3321	synthase
O165_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS07270	COG1199	ATP-dependent helicase activity
O165_RS07305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O165_RS07310	COG0590	tRNA wobble adenosine to inosine editing
O165_RS07315	COG2807	transmembrane transport
O165_RS07330	COG0247	lactate metabolic process
O165_RS07335	COG0277	FAD linked oxidase domain protein
O165_RS07340	COG0277	FAD linked oxidase domain protein
O165_RS07350	COG0583	DNA-binding transcription factor activity
O165_RS07360	COG4991	sh3 domain protein
O165_RS07365	COG1611	Belongs to the LOG family
O165_RS07410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS07440	COG1917	Cupin 2, conserved barrel domain protein
O165_RS07440	COG1396	sequence-specific DNA binding
O165_RS07450	COG3038	cytochrome b561
O165_RS07455	COG0753	catalase activity
O165_RS07460	COG1595	DNA-templated transcription, initiation
O165_RS07475	COG1250	3-hydroxyacyl-CoA dehydrogenase
O165_RS07480	COG0183	Belongs to the thiolase family
O165_RS07510	COG0534	Mate efflux family protein
O165_RS07520	COG0583	DNA-binding transcription factor activity
O165_RS07525	COG2814	Major facilitator Superfamily
O165_RS07530	COG1280	lysine exporter protein (LysE YggA)
O165_RS07545	COG1104	cysteine desulfurase activity
O165_RS07570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O165_RS07575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O165_RS07575	COG0316	Belongs to the HesB IscA family
O165_RS07590	COG1999	signal sequence binding
O165_RS07610	COG2207	Transcriptional regulator
O165_RS07615	COG2207	Transcriptional regulator
O165_RS07665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O165_RS07670	COG0708	Exodeoxyribonuclease III
O165_RS07680	COG0729	surface antigen
O165_RS07710	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS07715	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS07740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O165_RS07745	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS07750	COG0531	amino acid
O165_RS07760	COG2267	carboxylic ester hydrolase activity
O165_RS07765	COG2072	flavoprotein involved in K transport
O165_RS07800	COG2409	Drug exporters of the RND superfamily
O165_RS07815	COG2508	Transcriptional regulator
O165_RS07835	COG2366	antibiotic biosynthetic process
O165_RS07840	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O165_RS07850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O165_RS07855	COG0215	cysteine-tRNA ligase activity
O165_RS07865	COG0745	RESPONSE REGULATOR receiver
O165_RS07870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O165_RS07885	COG0829	nickel cation binding
O165_RS07890	COG0831	urea catabolic process
O165_RS07895	COG0832	Belongs to the urease beta subunit family
O165_RS07900	COG0804	urea catabolic process
O165_RS07905	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
O165_RS07915	COG0830	nickel cation binding
O165_RS07920	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O165_RS07930	COG1595	DNA-templated transcription, initiation
O165_RS07935	COG3712	iron ion homeostasis
O165_RS07960	COG4176	ABC-type proline glycine betaine transport system permease component
O165_RS07970	COG0840	transmembrane signaling receptor activity
O165_RS07975	COG2056	Na+-H+ antiporter family
O165_RS07985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O165_RS07990	COG1454	alcohol dehydrogenase
O165_RS08045	COG0726	polysaccharide deacetylase
O165_RS08055	COG1216	Glycosyl transferase, family 2
O165_RS08065	COG0438	transferase activity, transferring glycosyl groups
O165_RS08105	COG4774	siderophore transport
O165_RS08130	COG0583	DNA-binding transcription factor activity
O165_RS08135	COG1760	l-serine dehydratase
O165_RS08140	COG0814	amino acid
O165_RS08160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS08170	COG0174	glutamine synthetase
O165_RS08180	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS08185	COG0583	DNA-binding transcription factor activity
O165_RS08205	COG0826	peptidase U32
O165_RS08220	COG2384	SAM-dependent methyltransferase
O165_RS08225	COG2271	Major facilitator Superfamily
O165_RS08235	COG0583	DNA-binding transcription factor activity
O165_RS08250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O165_RS08255	COG2226	methyltransferase
O165_RS08270	COG1126	abc transporter atp-binding protein
O165_RS08275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS08315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS08320	COG0577	efflux transmembrane transporter activity
O165_RS08320	COG1136	(ABC) transporter
O165_RS08350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O165_RS08390	COG1595	DNA-templated transcription, initiation
O165_RS08445	COG3257	ureidoglycine aminohydrolase activity
O165_RS08460	COG1253	flavin adenine dinucleotide binding
O165_RS08470	COG2200	EAL domain
O165_RS08490	COG4191	Histidine kinase
O165_RS08490	COG0784	Response regulator, receiver
O165_RS08505	COG0814	amino acid
O165_RS08530	COG1538	Outer membrane efflux protein
O165_RS08570	COG4974	Belongs to the 'phage' integrase family
O165_RS08585	COG1196	nuclear chromosome segregation
O165_RS08585	COG0741	lytic transglycosylase activity
O165_RS08585	COG0739	heme binding
O165_RS08590	COG5002	protein histidine kinase activity
O165_RS08595	COG5002	protein histidine kinase activity
O165_RS08600	COG2204	response regulator
O165_RS08615	COG3265	gluconokinase activity
O165_RS08620	COG1609	Transcriptional regulator
O165_RS08630	COG2837	iron assimilation
O165_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS08655	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS08660	COG1960	acyl-CoA dehydrogenase activity
O165_RS08670	COG0531	amino acid
O165_RS08680	COG2207	Transcriptional regulator
O165_RS08680	COG3708	Transcriptional regulator
O165_RS08690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS08705	COG1201	RNA secondary structure unwinding
O165_RS08710	COG1793	dna ligase
O165_RS08735	COG1902	pentaerythritol trinitrate reductase activity
O165_RS08735	COG0446	pyridine nucleotide-disulphide oxidoreductase
O165_RS08745	COG1737	Transcriptional regulator
O165_RS08770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS08775	COG1073	alpha beta
O165_RS08805	COG2204	response regulator
O165_RS08810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O165_RS08835	COG4796	Type ii and iii secretion system protein
O165_RS08840	COG2165	general secretion pathway protein
O165_RS08870	COG1733	regulation of RNA biosynthetic process
O165_RS08885	COG0583	DNA-binding transcription factor activity
O165_RS08910	COG3706	GGDEF domain
O165_RS08910	COG4251	negative regulation of phosphorylation
O165_RS08910	COG2203	Gaf domain
O165_RS08910	COG5001	Diguanylate cyclase
O165_RS08915	COG1234	tRNA 3'-trailer cleavage
O165_RS08925	COG3971	2-oxopent-4-enoate hydratase activity
O165_RS08935	COG3384	dioxygenase
O165_RS08940	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS08950	COG0179	Fumarylacetoacetate (FAA) hydrolase
O165_RS08960	COG1846	Transcriptional regulator
O165_RS08990	COG2890	protein-(glutamine-N5) methyltransferase activity
O165_RS08995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O165_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS09020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O165_RS09050	COG0653	protein targeting
O165_RS09060	COG1238	metal cluster binding
O165_RS09080	COG4191	Histidine kinase
O165_RS09085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O165_RS09090	COG2814	Major facilitator Superfamily
O165_RS09210	COG0392	lysyltransferase activity
O165_RS09215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O165_RS09220	COG3568	Endonuclease Exonuclease Phosphatase
O165_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS09270	COG2030	dehydratase
O165_RS09290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O165_RS09295	COG2151	metal-sulfur cluster biosynthetic enzyme
O165_RS09300	COG3396	Phenylacetate-CoA oxygenase
O165_RS09305	COG3460	Phenylacetate-CoA oxygenase
O165_RS09310	COG3396	Phenylacetate-CoA oxygenase
O165_RS09320	COG0183	Belongs to the thiolase family
O165_RS09325	COG2050	protein possibly involved in aromatic compounds catabolism
O165_RS09330	COG1250	3-hydroxyacyl-CoA dehydrogenase
O165_RS09335	COG1024	Enoyl-CoA hydratase
O165_RS09340	COG1024	Enoyl-CoA hydratase
O165_RS09350	COG3327	negative regulation of DNA-templated transcription, initiation
O165_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS09375	COG3433	isochorismatase activity
O165_RS09375	COG1535	isochorismatase
O165_RS09380	COG1021	2,3-dihydroxybenzoate-AMP ligase
O165_RS09385	COG1169	isochorismate synthase
O165_RS09390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O165_RS09410	COG1132	(ABC) transporter
O165_RS09410	COG2375	cellular response to nickel ion
O165_RS09415	COG1132	(ABC) transporter
O165_RS09420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O165_RS09425	COG4605	iron ion homeostasis
O165_RS09430	COG4604	ABC transporter, ATP-binding protein
O165_RS09435	COG4607	ABC-type enterochelin transport system periplasmic component
O165_RS09440	COG4774	siderophore transport
O165_RS09445	COG0583	DNA-binding transcription factor activity
O165_RS09455	COG0840	transmembrane signaling receptor activity
O165_RS09470	COG2814	Major facilitator Superfamily
O165_RS09495	COG1566	PFAM secretion protein HlyD family protein
O165_RS09520	COG0411	ABC transporter
O165_RS09535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O165_RS09540	COG0579	oxidoreductase
O165_RS09550	COG1802	Transcriptional regulator
O165_RS09565	COG3344	reverse transcriptase
O165_RS09615	COG1250	3-hydroxyacyl-CoA dehydrogenase
O165_RS09620	COG1024	Enoyl-CoA hydratase
O165_RS09630	COG1960	acyl-CoA dehydrogenase activity
O165_RS09640	COG1942	4-Oxalocrotonate Tautomerase
O165_RS09645	COG0583	DNA-binding transcription factor activity
O165_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS09680	COG3384	dioxygenase
O165_RS09700	COG4974	Belongs to the 'phage' integrase family
O165_RS09785	COG2986	histidine ammonia-lyase
O165_RS09790	COG4175	Glycine betaine
O165_RS09795	COG4176	ABC-type proline glycine betaine transport system permease component
O165_RS09810	COG0534	Mate efflux family protein
O165_RS09835	COG0583	DNA-binding transcription factor activity
O165_RS09875	COG0668	transmembrane transport
O165_RS09885	COG0028	Belongs to the TPP enzyme family
O165_RS09890	COG0693	protein deglycase activity
O165_RS09900	COG0789	Transcriptional regulator
O165_RS09905	COG1366	Belongs to the anti-sigma-factor antagonist family
O165_RS09915	COG4221	oxidoreductase activity
O165_RS09930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O165_RS09940	COG3046	protein related to deoxyribodipyrimidine photolyase
O165_RS09980	COG2267	carboxylic ester hydrolase activity
O165_RS09985	COG2771	luxR family
O165_RS09990	COG2267	carboxylic ester hydrolase activity
O165_RS09995	COG0601	transmembrane transport
O165_RS10000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O165_RS10005	COG0444	Belongs to the ABC transporter superfamily
O165_RS10010	COG4608	Belongs to the ABC transporter superfamily
O165_RS10030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O165_RS10095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O165_RS10100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O165_RS10110	COG4174	ABC transporter (Permease)
O165_RS10115	COG4239	(ABC) transporter, permease
O165_RS10120	COG3829	transcription factor binding
O165_RS10120	COG3290	protein histidine kinase activity
O165_RS10125	COG2610	gluconate transmembrane transporter activity
O165_RS10130	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS10135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O165_RS10140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O165_RS10145	COG0840	transmembrane signaling receptor activity
O165_RS10170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O165_RS10195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O165_RS10200	COG1247	-acetyltransferase
O165_RS10255	COG2135	peptidase activity
O165_RS10270	COG3179	chitinase
O165_RS10500	COG3646	Phage regulatory protein
O165_RS10590	COG0629	single-stranded DNA binding
O165_RS10615	COG0270	DNA (cytosine-5-)-methyltransferase activity
O165_RS10665	COG0488	(ABC) transporter
O165_RS10680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O165_RS10785	COG2207	Transcriptional regulator
O165_RS10790	COG1396	sequence-specific DNA binding
O165_RS10795	COG0235	Class ii aldolase
O165_RS10800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O165_RS10805	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
O165_RS10860	COG2031	fatty acid transporter
O165_RS10870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O165_RS10880	COG0656	L-ascorbic acid biosynthetic process
O165_RS10885	COG0587	DNA-directed DNA polymerase activity
O165_RS10900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O165_RS10925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O165_RS10940	COG0583	DNA-binding transcription factor activity
O165_RS10955	COG2207	Transcriptional regulator
O165_RS10960	COG0789	Transcriptional regulator
O165_RS10970	COG1285	pathogenesis
O165_RS10975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O165_RS11005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O165_RS11015	COG3145	DNA-N1-methyladenine dioxygenase activity
O165_RS11025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O165_RS11055	COG0811	peptide transport
O165_RS11080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O165_RS11085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O165_RS11090	COG2271	Major facilitator Superfamily
O165_RS11095	COG2721	sulfolactate sulfo-lyase activity
O165_RS11100	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS11105	COG2186	Transcriptional regulator
O165_RS11110	COG2207	Transcriptional regulator
O165_RS11145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O165_RS11155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O165_RS11165	COG1609	Transcriptional regulator
O165_RS11170	COG0768	penicillin binding
O165_RS11190	COG2258	MOSC domain
O165_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS11215	COG2197	response regulator
O165_RS11230	COG1960	acyl-CoA dehydrogenase activity
O165_RS11240	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS11285	COG1132	(ABC) transporter
O165_RS11290	COG3284	Transcriptional regulator
O165_RS11325	COG1968	undecaprenyl-diphosphatase activity
O165_RS11330	COG0840	transmembrane signaling receptor activity
O165_RS11430	COG3813	Protein conserved in bacteria
O165_RS11435	COG2197	response regulator
O165_RS11440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS11440	COG2205	protein histidine kinase activity
O165_RS11460	COG0346	lactoylglutathione lyase activity
O165_RS11480	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS11505	COG0477	Major facilitator Superfamily
O165_RS11525	COG2837	iron assimilation
O165_RS11530	COG2116	formate transmembrane transporter activity
O165_RS11540	COG0633	Ferredoxin
O165_RS11540	COG3217	Mosc domain protein beta barrel domain protein
O165_RS11560	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS11580	COG3712	iron ion homeostasis
O165_RS11605	COG0251	oxidation-reduction process
O165_RS11635	COG1984	allophanate hydrolase subunit 2
O165_RS11645	COG0439	Biotin carboxylase
O165_RS11655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O165_RS11675	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O165_RS11675	COG0456	acetyltransferase
O165_RS11680	COG0445	tRNA wobble uridine modification
O165_RS11695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O165_RS11700	COG0348	domain, Protein
O165_RS11705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS11715	COG4191	Histidine kinase
O165_RS11715	COG0784	Response regulator, receiver
O165_RS11720	COG4191	Histidine kinase
O165_RS11720	COG0784	Response regulator, receiver
O165_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS11730	COG2814	Major facilitator Superfamily
O165_RS11735	COG1566	PFAM secretion protein HlyD family protein
O165_RS11740	COG1846	Transcriptional regulator
O165_RS11745	COG1929	Belongs to the glycerate kinase type-1 family
O165_RS11750	COG3835	regulator
O165_RS11755	COG2271	Major facilitator Superfamily
O165_RS11775	COG0583	DNA-binding transcription factor activity
O165_RS11780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O165_RS11815	COG0454	-acetyltransferase
O165_RS11820	COG1686	Belongs to the peptidase S11 family
O165_RS11840	COG0784	Response regulator, receiver
O165_RS11840	COG2198	Histidine kinase
O165_RS11840	COG2205	protein histidine kinase activity
O165_RS11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS11845	COG5002	protein histidine kinase activity
O165_RS11845	COG0784	Response regulator, receiver
O165_RS11845	COG2205	protein histidine kinase activity
O165_RS11855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O165_RS11860	COG4999	Histidine kinase
O165_RS11860	COG2205	protein histidine kinase activity
O165_RS11860	COG3437	response regulator, receiver
O165_RS11860	COG3850	Histidine kinase
O165_RS11885	COG1959	2 iron, 2 sulfur cluster binding
O165_RS11905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O165_RS11910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O165_RS11915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O165_RS11925	COG2267	carboxylic ester hydrolase activity
O165_RS11930	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS11940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O165_RS11945	COG2186	Transcriptional regulator
O165_RS11950	COG2816	NAD+ diphosphatase activity
O165_RS11955	COG0784	Response regulator, receiver
O165_RS11955	COG4191	Histidine kinase
O165_RS11965	COG1280	lysine exporter protein (LysE YggA)
O165_RS12030	COG1121	(ABC) transporter
O165_RS12035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O165_RS12080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS12095	COG2814	Major facilitator Superfamily
O165_RS12115	COG0625	glutathione transferase activity
O165_RS12135	COG0393	Putative heavy-metal-binding
O165_RS12150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O165_RS12150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O165_RS12165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O165_RS12170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O165_RS12170	COG0515	serine threonine protein kinase
O165_RS12180	COG0500	methyltransferase
O165_RS12205	COG1917	Cupin 2, conserved barrel domain protein
O165_RS12205	COG4977	sequence-specific DNA binding
O165_RS12215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O165_RS12220	COG1215	transferase activity, transferring glycosyl groups
O165_RS12235	COG5001	Diguanylate cyclase
O165_RS12240	COG2205	protein histidine kinase activity
O165_RS12245	COG0745	RESPONSE REGULATOR receiver
O165_RS12250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS12260	COG0746	molybdenum cofactor guanylyltransferase activity
O165_RS12275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS12285	COG0667	Aldo Keto reductase
O165_RS12295	COG2814	Major facilitator Superfamily
O165_RS12300	COG0583	DNA-binding transcription factor activity
O165_RS12310	COG0583	DNA-binding transcription factor activity
O165_RS12315	COG1280	lysine exporter protein (LysE YggA)
O165_RS12335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O165_RS12365	COG1064	alcohol dehydrogenase
O165_RS12370	COG2207	Transcriptional regulator
O165_RS12380	COG2249	NAD(P)H dehydrogenase (quinone) activity
O165_RS12400	COG1869	D-ribose catabolic process
O165_RS12405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O165_RS12410	COG1609	Transcriptional regulator
O165_RS12415	COG1172	Belongs to the binding-protein-dependent transport system permease family
O165_RS12420	COG1129	ABC transporter
O165_RS12430	COG0252	asparaginase activity
O165_RS12445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O165_RS12450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O165_RS12470	COG1879	ABC-type sugar transport system periplasmic component
O165_RS12485	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
O165_RS12495	COG2814	Major facilitator Superfamily
O165_RS12500	COG3634	alkyl hydroperoxide reductase activity
O165_RS12520	COG3258	Cytochrome c
O165_RS12525	COG2863	cytochrome
O165_RS12550	COG1944	ATP diphosphatase activity
O165_RS12570	COG3011	Protein conserved in bacteria
O165_RS12585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O165_RS12620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
O165_RS12640	COG1063	alcohol dehydrogenase
O165_RS12670	COG0322	excinuclease ABC activity
O165_RS12690	COG1215	transferase activity, transferring glycosyl groups
O165_RS12710	COG1696	Membrane protein involved in D-alanine export
O165_RS12750	COG0306	phosphate transporter
O165_RS12755	COG0625	glutathione transferase activity
O165_RS12770	COG4774	siderophore transport
O165_RS12780	COG1252	NADH dehydrogenase
O165_RS12790	COG3220	belongs to the UPF0276 family
O165_RS12810	COG0417	DNA replication proofreading
O165_RS12820	COG0583	DNA-binding transcription factor activity
O165_RS12855	COG2259	Doxx family
O165_RS12890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O165_RS12895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O165_RS12975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O165_RS12990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O165_RS12995	COG0659	secondary active sulfate transmembrane transporter activity
O165_RS13015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O165_RS13020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O165_RS13025	COG0649	NAD binding
O165_RS13025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O165_RS13040	COG1034	ATP synthesis coupled electron transport
O165_RS13045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O165_RS13050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O165_RS13060	COG0713	ATP synthesis coupled electron transport
O165_RS13075	COG1007	ATP synthesis coupled electron transport
O165_RS13090	COG0826	peptidase U32
O165_RS13095	COG2132	Multicopper oxidase
O165_RS13110	COG1238	metal cluster binding
O165_RS13145	COG4789	Type iii secretion
O165_RS13195	COG4790	Type iii secretion
O165_RS13200	COG4794	Type iii secretion
O165_RS13210	COG4792	protein secretion
O165_RS13290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O165_RS13295	COG2133	pyrroloquinoline quinone binding
O165_RS13315	COG0583	DNA-binding transcription factor activity
O165_RS13345	COG0589	response to stress
O165_RS13355	COG0517	IMP dehydrogenase activity
O165_RS13355	COG0617	tRNA 3'-terminal CCA addition
O165_RS13355	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O165_RS13385	COG0720	synthase
O165_RS13405	COG2079	MmgE PrpD family protein
O165_RS13420	COG0372	Belongs to the citrate synthase family
O165_RS13430	COG1802	Transcriptional regulator
O165_RS13435	COG4067	protein conserved in archaea
O165_RS13435	COG0189	ligase activity
O165_RS13465	COG0589	response to stress
O165_RS13470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O165_RS13505	COG4181	ATPase activity
O165_RS13510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
O165_RS13515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O165_RS13525	COG2259	Doxx family
O165_RS13530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O165_RS13535	COG0084	hydrolase, TatD family'
O165_RS13570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O165_RS13580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O165_RS13585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O165_RS13590	COG0740	serine-type endopeptidase activity
O165_RS13595	COG0544	peptidyl-prolyl cis-trans isomerase activity
O165_RS13625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O165_RS13635	COG2423	ornithine cyclodeaminase activity
O165_RS13645	COG4215	(ABC) transporter
O165_RS13670	COG0840	transmembrane signaling receptor activity
O165_RS13695	COG4977	sequence-specific DNA binding
O165_RS13725	COG0583	DNA-binding transcription factor activity
O165_RS13730	COG0840	transmembrane signaling receptor activity
O165_RS13735	COG0251	oxidation-reduction process
O165_RS13740	COG0730	response to heat
O165_RS13855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O165_RS13855	COG2111	Na H antiporter
O165_RS13860	COG1006	Multisubunit Na H antiporter MnhC subunit
O165_RS13865	COG0651	ATP synthesis coupled electron transport
O165_RS13875	COG2212	antiporter activity
O165_RS13880	COG1320	monovalent cation:proton antiporter activity
O165_RS13925	COG1024	Enoyl-CoA hydratase
O165_RS13930	COG1960	acyl-CoA dehydrogenase activity
O165_RS13935	COG0183	Belongs to the thiolase family
O165_RS13945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O165_RS13965	COG0583	DNA-binding transcription factor activity
O165_RS13970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O165_RS13975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O165_RS13980	COG0431	NADPH-dependent FMN reductase
O165_RS14000	COG0328	RNA-DNA hybrid ribonuclease activity
O165_RS14010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O165_RS14015	COG1388	LysM domain
O165_RS14015	COG0741	lytic transglycosylase activity
O165_RS14020	COG4166	transmembrane transport
O165_RS14025	COG4166	transmembrane transport
O165_RS14030	COG4174	ABC transporter (Permease)
O165_RS14035	COG4239	(ABC) transporter, permease
O165_RS14040	COG4172	Belongs to the ABC transporter superfamily
O165_RS14075	COG0531	amino acid
O165_RS14080	COG2197	response regulator
O165_RS14095	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O165_RS14120	COG2271	Major facilitator Superfamily
O165_RS14130	COG2851	Citrate transporter
O165_RS14135	COG1301	dicarboxylic acid transport
O165_RS14140	COG2828	Protein conserved in bacteria
O165_RS14145	COG0583	DNA-binding transcription factor activity
O165_RS14165	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
O165_RS14170	COG0288	reversible hydration of carbon dioxide
O165_RS14175	COG0583	DNA-binding transcription factor activity
O165_RS14185	COG0583	DNA-binding transcription factor activity
O165_RS14195	COG3706	GGDEF domain
O165_RS14205	COG2205	protein histidine kinase activity
O165_RS14210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
O165_RS14220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
O165_RS14230	COG0628	permease
O165_RS14240	COG0596	Alpha beta hydrolase
O165_RS14255	COG2062	phosphohistidine phosphatase, SixA
O165_RS14265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O165_RS14280	COG4999	Histidine kinase
O165_RS14280	COG2205	protein histidine kinase activity
O165_RS14280	COG3437	response regulator, receiver
O165_RS14280	COG3850	Histidine kinase
O165_RS14285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O165_RS14305	COG1741	Belongs to the pirin family
O165_RS14315	COG0326	Molecular chaperone. Has ATPase activity
O165_RS14350	COG0045	succinate-CoA ligase (ADP-forming) activity
O165_RS14355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O165_RS14375	COG1053	succinate dehydrogenase
O165_RS14380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O165_RS14385	COG2009	succinate dehydrogenase
O165_RS14410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS14430	COG0116	Belongs to the methyltransferase superfamily
O165_RS14430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O165_RS14435	COG0167	dihydroorotate dehydrogenase activity
O165_RS14440	COG1116	anion transmembrane transporter activity
O165_RS14440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O165_RS14445	COG3707	response regulator
O165_RS14450	COG2223	nitrite transmembrane transporter activity
O165_RS14455	COG0515	serine threonine protein kinase
O165_RS14470	COG0668	transmembrane transport
O165_RS14485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O165_RS14500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O165_RS14515	COG2186	Transcriptional regulator
O165_RS14520	COG0579	oxidoreductase
O165_RS14530	COG0714	Associated with various cellular activities
O165_RS14560	COG0420	3'-5' exonuclease activity
O165_RS14575	COG2706	6-phosphogluconolactonase activity
O165_RS14595	COG0308	aminopeptidase N
O165_RS14605	COG3139	Protein of unknown function (DUF1315)
O165_RS14615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O165_RS14620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O165_RS14630	COG3038	cytochrome b561
O165_RS14645	COG1902	pentaerythritol trinitrate reductase activity
O165_RS14645	COG0446	pyridine nucleotide-disulphide oxidoreductase
O165_RS14700	COG1286	toxin biosynthetic process
O165_RS14710	COG0285	dihydrofolate synthase activity
O165_RS14715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O165_RS14720	COG0135	phosphoribosylanthranilate isomerase activity
O165_RS14760	COG0473	3-isopropylmalate dehydrogenase activity
O165_RS14765	COG0066	3-isopropylmalate dehydratase activity
O165_RS14770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O165_RS14790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O165_RS14800	COG0596	Alpha beta hydrolase
O165_RS14840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O165_RS14855	COG0556	nucleotide-excision repair
O165_RS14900	COG1138	Cytochrome C-type biogenesis protein
O165_RS14905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O165_RS14925	COG4133	protoheme IX ABC transporter activity
O165_RS14935	COG2257	FlhB HrpN YscU SpaS Family
O165_RS14950	COG0835	chemotaxis
O165_RS14960	COG1192	Involved in chromosome partitioning
O165_RS14965	COG1360	Flagellar Motor Protein
O165_RS14970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O165_RS14975	COG2201	protein-glutamate methylesterase activity
O165_RS14980	COG2198	Histidine kinase
O165_RS14980	COG0643	Histidine kinase
O165_RS14980	COG0784	Response regulator, receiver
O165_RS14985	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
O165_RS15025	COG1987	bacterial-type flagellum assembly
O165_RS15065	COG0745	RESPONSE REGULATOR receiver
O165_RS15075	COG2882	bacterial-type flagellum organization
O165_RS15100	COG1677	Flagellar hook-basal body complex protein FliE
O165_RS15135	COG1334	flagellar protein FlaG
O165_RS15145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O165_RS15165	COG1706	bacterial-type flagellum-dependent cell motility
O165_RS15170	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O165_RS15180	COG4787	bacterial-type flagellum-dependent cell motility
O165_RS15190	COG1749	Flagellar hook protein flgE
O165_RS15205	COG1815	bacterial-type flagellum-dependent cell motility
O165_RS15210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O165_RS15215	COG0784	Response regulator, receiver
O165_RS15215	COG0835	chemotaxis
O165_RS15235	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
O165_RS15240	COG0477	Major facilitator Superfamily
O165_RS15250	COG1522	sequence-specific DNA binding
O165_RS15255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O165_RS15260	COG0022	dehydrogenase e1 component
O165_RS15270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O165_RS15275	COG3706	GGDEF domain
O165_RS15290	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
O165_RS15300	COG2239	Acts as a magnesium transporter
O165_RS15330	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O165_RS15335	COG0527	aspartate kinase activity
O165_RS15340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O165_RS15345	COG2988	succinylglutamate desuccinylase activity
O165_RS15355	COG3724	N-succinylarginine dihydrolase activity
O165_RS15360	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS15375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O165_RS15395	COG4215	(ABC) transporter
O165_RS15400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS15405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O165_RS15425	COG2154	pterin-4-alpha-carbinolamine dehydratase
O165_RS15445	COG0247	lactate metabolic process
O165_RS15445	COG0277	FAD linked oxidase domain protein
O165_RS15450	COG0583	DNA-binding transcription factor activity
O165_RS15455	COG1113	amino acid transport
O165_RS15465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O165_RS15475	COG0009	L-threonylcarbamoyladenylate synthase
O165_RS15480	COG0613	PHP domain protein
O165_RS15485	COG2917	probably involved in intracellular septation
O165_RS15490	COG2350	Protein conserved in bacteria
O165_RS15500	COG0745	RESPONSE REGULATOR receiver
O165_RS15515	COG0778	Nitroreductase
O165_RS15520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O165_RS15545	COG2207	Transcriptional regulator
O165_RS15560	COG1752	Esterase of the alpha-beta hydrolase superfamily
O165_RS15580	COG2832	Protein of unknown function (DUF454)
O165_RS15600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS15610	COG0840	transmembrane signaling receptor activity
O165_RS15625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O165_RS15630	COG0367	asparagine synthase
O165_RS15635	COG0189	ligase activity
O165_RS15635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O165_RS15640	COG1363	Peptidase, m42
O165_RS15645	COG3089	Belongs to the UPF0270 family
O165_RS15650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O165_RS15665	COG2205	protein histidine kinase activity
O165_RS15665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS15670	COG2197	response regulator
O165_RS15695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O165_RS15700	COG3162	membrane
O165_RS15705	COG2113	Glycine betaine
O165_RS15725	COG2853	Lipoprotein
O165_RS15735	COG1560	Kdo2-lipid A biosynthetic process
O165_RS15740	COG0850	regulation of cytokinetic process
O165_RS15745	COG2894	cell division
O165_RS15750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O165_RS15755	COG0564	pseudouridine synthase activity
O165_RS15760	COG1362	aminopeptidase activity
O165_RS15770	COG0668	transmembrane transport
O165_RS15785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O165_RS15790	COG0395	ABC-type sugar transport system, permease component
O165_RS15810	COG0385	Bile acid
O165_RS15815	COG2076	Multidrug Resistance protein
O165_RS15820	COG0477	Major facilitator Superfamily
O165_RS15830	COG2814	Major facilitator Superfamily
O165_RS15835	COG2205	protein histidine kinase activity
O165_RS15885	COG1846	Transcriptional regulator
O165_RS15890	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O165_RS15895	COG0406	alpha-ribazole phosphatase activity
O165_RS15900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O165_RS15910	COG1492	cobalamin metabolic process
O165_RS15920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
O165_RS15925	COG0778	Nitroreductase
O165_RS15930	COG1797	cobyrinic acid a,c-diamide synthase activity
O165_RS15945	COG0791	NLP P60 protein
O165_RS15950	COG0791	NLP P60 protein
O165_RS15960	COG0628	permease
O165_RS15970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O165_RS15975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O165_RS15990	COG3122	Protein conserved in bacteria
O165_RS15995	COG3956	TIGRFAM MazG family protein
O165_RS16000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O165_RS16005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O165_RS16025	COG5002	protein histidine kinase activity
O165_RS16025	COG2205	protein histidine kinase activity
O165_RS16025	COG0784	Response regulator, receiver
O165_RS16030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O165_RS16050	COG1393	Belongs to the ArsC family
O165_RS16070	COG0037	tRNA processing
O165_RS16080	COG3091	SprT-like family
O165_RS16085	COG1301	dicarboxylic acid transport
O165_RS16115	COG2205	protein histidine kinase activity
O165_RS16120	COG0745	RESPONSE REGULATOR receiver
O165_RS16125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O165_RS16125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O165_RS16130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O165_RS16160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS16170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O165_RS16170	COG1017	nitric oxide dioxygenase activity
O165_RS16175	COG0625	glutathione transferase activity
O165_RS16180	COG3012	SEC-C Motif Domain Protein
O165_RS16180	COG3318	Belongs to the UPF0149 family
O165_RS16185	COG0252	asparaginase activity
O165_RS16195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O165_RS16235	COG2116	formate transmembrane transporter activity
O165_RS16245	COG3706	GGDEF domain
O165_RS16250	COG5001	Diguanylate cyclase
O165_RS16265	COG0583	DNA-binding transcription factor activity
O165_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS16280	COG4221	oxidoreductase activity
O165_RS16315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O165_RS16325	COG2084	Dehydrogenase
O165_RS16370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
O165_RS16385	COG0259	pyridoxamine-phosphate oxidase activity
O165_RS16390	COG2885	chlorophyll binding
O165_RS16405	COG1199	ATP-dependent helicase activity
O165_RS16440	COG3012	SEC-C Motif Domain Protein
O165_RS16450	COG0653	protein targeting
O165_RS16455	COG2366	antibiotic biosynthetic process
O165_RS16460	COG1598	PFAM Uncharacterised protein family UPF0150
O165_RS16465	COG1724	mRNA binding
O165_RS16480	COG0717	Belongs to the dCTP deaminase family
O165_RS16485	COG1278	Cold shock
O165_RS16490	COG0489	protein tyrosine kinase activity
O165_RS16495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O165_RS16495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O165_RS16500	COG4657	Part of a membrane complex involved in electron transport
O165_RS16510	COG4659	FMN binding
O165_RS16520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O165_RS16530	COG2197	response regulator
O165_RS16540	COG0137	argininosuccinate synthase activity
O165_RS16550	COG0418	dihydroorotase activity
O165_RS16555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O165_RS16560	COG0450	alkyl hydroperoxide reductase
O165_RS16575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O165_RS16580	COG0243	molybdopterin cofactor binding
O165_RS16585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O165_RS16590	COG3842	ATPase activity
O165_RS16600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O165_RS16610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O165_RS16630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS16635	COG0765	amino acid transport
O165_RS16640	COG0765	amino acid transport
O165_RS16645	COG1126	abc transporter atp-binding protein
O165_RS16650	COG4191	Histidine kinase
O165_RS16665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O165_RS16675	COG0583	DNA-binding transcription factor activity
O165_RS16685	COG1201	RNA secondary structure unwinding
O165_RS16690	COG0254	rRNA binding
O165_RS16695	COG0069	glutamate synthase activity
O165_RS16700	COG1113	amino acid transport
O165_RS16710	COG1695	Transcriptional regulator
O165_RS16715	COG2375	cellular response to nickel ion
O165_RS16725	COG1073	alpha beta
O165_RS16745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O165_RS16755	COG0742	ribosomal rna small subunit methyltransferase
O165_RS16790	COG0563	adenylate kinase activity
O165_RS16795	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O165_RS16810	COG2885	chlorophyll binding
O165_RS16825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O165_RS16830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O165_RS16835	COG0585	pseudouridine synthase activity
O165_RS16840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O165_RS16845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O165_RS16850	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O165_RS16860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O165_RS16870	COG0148	phosphopyruvate hydratase activity
O165_RS16875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
O165_RS16880	COG0504	CTP synthase activity
O165_RS16885	COG0037	tRNA processing
O165_RS16890	COG0825	malonyl-CoA metabolic process
O165_RS16900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O165_RS16905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O165_RS16910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O165_RS16915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O165_RS16920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O165_RS16940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O165_RS16950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O165_RS16955	COG0233	cytoplasmic translational termination
O165_RS16960	COG0528	UMP kinase activity
O165_RS16965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O165_RS16970	COG0052	Belongs to the universal ribosomal protein uS2 family
O165_RS16975	COG0024	Methionine aminopeptidase
O165_RS16980	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O165_RS16985	COG0436	Aminotransferase
O165_RS16990	COG0025	NhaP-type Na H and K H
O165_RS16995	COG1393	Belongs to the ArsC family
O165_RS17000	COG2171	N-acyltransferase activity
O165_RS17005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O165_RS17010	COG2166	iron-sulfur cluster assembly
O165_RS17015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O165_RS17020	COG1215	transferase activity, transferring glycosyl groups
O165_RS17030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O165_RS17035	COG2226	methyltransferase
O165_RS17050	COG2937	Belongs to the GPAT DAPAT family
O165_RS17065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS17085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O165_RS17135	COG4974	Belongs to the 'phage' integrase family
O165_RS17140	COG3263	regulation of cellular component size
O165_RS17145	COG1607	acyl-coa hydrolase
O165_RS17150	COG0335	large ribosomal subunit rRNA binding
O165_RS17155	COG0336	Belongs to the RNA methyltransferase TrmD family
O165_RS17160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O165_RS17165	COG0228	four-way junction DNA binding
O165_RS17170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O165_RS17180	COG4536	flavin adenine dinucleotide binding
O165_RS17185	COG0477	Major facilitator Superfamily
O165_RS17190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O165_RS17275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O165_RS17305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O165_RS17310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O165_RS17320	COG2188	Transcriptional regulator
O165_RS17325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O165_RS17330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O165_RS17335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O165_RS17335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O165_RS17340	COG1263	PTS System
O165_RS17340	COG2190	(PTS) system
O165_RS17340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O165_RS17345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O165_RS17350	COG0047	phosphoribosylformylglycinamidine synthase activity
O165_RS17350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O165_RS17355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O165_RS17360	COG0590	tRNA wobble adenosine to inosine editing
O165_RS17395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O165_RS17395	COG0519	Catalyzes the synthesis of GMP from XMP
O165_RS17420	COG1570	exodeoxyribonuclease VII activity
O165_RS17425	COG0739	heme binding
O165_RS17430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O165_RS17435	COG0800	Aldolase
O165_RS17450	COG1737	Transcriptional regulator
O165_RS17455	COG0676	glucose-6-phosphate 1-epimerase activity
O165_RS17465	COG3842	ATPase activity
O165_RS17475	COG1175	transmembrane transport
O165_RS17535	COG2832	Protein of unknown function (DUF454)
O165_RS17550	COG2235	arginine
O165_RS17555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O165_RS17575	COG0509	glycine decarboxylation via glycine cleavage system
O165_RS17580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O165_RS17580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O165_RS17585	COG1760	l-serine dehydratase
O165_RS17590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O165_RS17595	COG1278	Cold shock
O165_RS17605	COG0795	lipopolysaccharide-transporting ATPase activity
O165_RS17610	COG0795	lipopolysaccharide-transporting ATPase activity
O165_RS17615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O165_RS17630	COG0525	valine-tRNA ligase activity
O165_RS17635	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
O165_RS17645	COG3081	Nucleoid-associated protein
O165_RS17670	COG3081	Nucleoid-associated protein
O165_RS17675	COG4581	dead DEAH box helicase
O165_RS17705	COG3081	Nucleoid-associated protein
O165_RS17715	COG2827	Endonuclease containing a URI domain
O165_RS17725	COG2807	transmembrane transport
O165_RS17730	COG2186	Transcriptional regulator
O165_RS17735	COG1113	amino acid transport
O165_RS17755	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
O165_RS17770	COG0747	negative chemotaxis
O165_RS17775	COG0747	negative chemotaxis
O165_RS17785	COG0747	negative chemotaxis
O165_RS17790	COG0601	transmembrane transport
O165_RS17795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O165_RS17800	COG0444	Belongs to the ABC transporter superfamily
O165_RS17805	COG4608	Belongs to the ABC transporter superfamily
O165_RS17820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS17835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O165_RS17860	COG4772	TonB-dependent receptor
O165_RS17875	COG0019	diaminopimelate decarboxylase activity
O165_RS17885	COG3128	pkhd-type hydroxylase
O165_RS17900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O165_RS17905	COG0436	Aminotransferase
O165_RS17910	COG1160	GTP binding
O165_RS17925	COG0124	histidyl-tRNA synthetase
O165_RS17930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O165_RS17945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O165_RS17950	COG0105	UTP biosynthetic process
O165_RS17960	COG0633	Ferredoxin
O165_RS17965	COG0443	Heat shock 70 kDa protein
O165_RS17970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O165_RS17975	COG0316	Belongs to the HesB IscA family
O165_RS17985	COG1104	cysteine desulfurase activity
O165_RS17995	COG1045	serine acetyltransferase
O165_RS18010	COG3134	Outer membrane lipoprotein
O165_RS18025	COG1862	Preprotein translocase
O165_RS18030	COG0343	queuine tRNA-ribosyltransferase activity
O165_RS18035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O165_RS18045	COG0582	viral genome integration into host DNA
O165_RS18135	COG3781	membrane
O165_RS18145	COG3022	response to hydroperoxide
O165_RS18150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O165_RS18155	COG1215	transferase activity, transferring glycosyl groups
O165_RS18160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS18165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
O165_RS18175	COG3420	alginic acid biosynthetic process
O165_RS18190	COG1696	Membrane protein involved in D-alanine export
O165_RS18205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
O165_RS18205	COG0662	Cupin 2, conserved barrel domain protein
O165_RS18215	COG0300	oxidoreductase activity
O165_RS18245	COG1566	PFAM secretion protein HlyD family protein
O165_RS18265	COG0583	DNA-binding transcription factor activity
O165_RS18270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O165_RS18280	COG3708	Transcriptional regulator
O165_RS18280	COG2207	Transcriptional regulator
O165_RS18315	COG0386	Belongs to the glutathione peroxidase family
O165_RS18330	COG0857	belongs to the CobB CobQ family
O165_RS18330	COG0280	phosphate acetyltransferase
O165_RS18360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O165_RS18375	COG2026	Addiction module toxin, RelE StbE family
O165_RS18390	COG2205	protein histidine kinase activity
O165_RS18395	COG0596	Alpha beta hydrolase
O165_RS18495	COG0582	viral genome integration into host DNA
O165_RS18520	COG0237	dephospho-CoA kinase activity
O165_RS18525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
O165_RS18550	COG1252	NADH dehydrogenase
O165_RS18555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O165_RS18575	COG0542	response to heat
O165_RS18600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS18630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O165_RS18635	COG1047	Peptidyl-prolyl cis-trans
O165_RS18640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O165_RS18645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O165_RS18650	COG0196	riboflavin kinase activity
O165_RS18660	COG0268	Binds directly to 16S ribosomal RNA
O165_RS18665	COG3008	intermembrane lipid transfer
O165_RS18670	COG2995	paraquat-inducible protein a
O165_RS18675	COG2995	paraquat-inducible protein a
O165_RS18720	COG1309	transcriptional regulator
O165_RS18735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O165_RS18745	COG2814	Major facilitator Superfamily
O165_RS18770	COG0840	transmembrane signaling receptor activity
O165_RS18775	COG2207	Transcriptional regulator
O165_RS18785	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS18800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O165_RS18870	COG4964	Belongs to the GSP D family
O165_RS18900	COG3485	protocatechuate 3,4-dioxygenase
O165_RS18905	COG3485	protocatechuate 3,4-dioxygenase
O165_RS18910	COG2321	neutral zinc metallopeptidase
O165_RS18915	COG0840	transmembrane signaling receptor activity
O165_RS18925	COG0583	DNA-binding transcription factor activity
O165_RS18930	COG2249	NAD(P)H dehydrogenase (quinone) activity
O165_RS18950	COG1166	arginine decarboxylase activity
O165_RS18955	COG0023	Translation Initiation Factor
O165_RS18985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O165_RS19050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
O165_RS19055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O165_RS19060	COG1183	phosphatidylcholine synthase activity
O165_RS19065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O165_RS19075	COG0028	Belongs to the TPP enzyme family
O165_RS19080	COG3098	single-species biofilm formation
O165_RS19090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O165_RS19115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O165_RS19120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O165_RS19125	COG4558	Periplasmic binding protein
O165_RS19135	COG1489	DNA binding
O165_RS19140	COG0436	Aminotransferase
O165_RS19150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O165_RS19160	COG4191	Histidine kinase
O165_RS19165	COG2204	response regulator
O165_RS19170	COG0617	tRNA 3'-terminal CCA addition
O165_RS19180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O165_RS19185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O165_RS19190	COG0166	Belongs to the GPI family
O165_RS19195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O165_RS19200	COG0640	Transcriptional regulator
O165_RS19210	COG2329	Antibiotic biosynthesis monooxygenase
O165_RS19235	COG2823	Periplasmic or secreted lipoprotein
O165_RS19240	COG1185	polyribonucleotide nucleotidyltransferase activity
O165_RS19245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O165_RS19250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O165_RS19255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O165_RS19260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O165_RS19265	COG0195	Participates in both transcription termination and antitermination
O165_RS19270	COG0779	Required for maturation of 30S ribosomal subunits
O165_RS19285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O165_RS19290	COG0149	triose-phosphate isomerase activity
O165_RS19295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O165_RS19300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O165_RS19310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O165_RS19325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O165_RS19330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O165_RS19335	COG0505	Belongs to the CarA family
O165_RS19340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O165_RS19345	COG0484	heat shock protein binding
O165_RS19350	COG0443	Heat shock 70 kDa protein
O165_RS19355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O165_RS19360	COG0497	DNA recombination
O165_RS19370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O165_RS19380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O165_RS19385	COG2186	Transcriptional regulator
O165_RS19390	COG1620	l-lactate permease
O165_RS19395	COG1304	FMN binding
O165_RS19405	COG2264	protein methyltransferase activity
O165_RS19415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O165_RS19425	COG0138	bifunctional purine biosynthesis protein purh
O165_RS19430	COG0151	Belongs to the GarS family
O165_RS19440	COG2095	MarC family integral membrane protein
O165_RS19460	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O165_RS19470	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
O165_RS19495	COG0330	HflC and HflK could
O165_RS19525	COG1113	amino acid transport
O165_RS19565	COG0789	Transcriptional regulator
O165_RS19570	COG0484	heat shock protein binding
O165_RS19575	COG0443	Heat shock 70 kDa protein
O165_RS19595	COG0697	spore germination
O165_RS19600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O165_RS19615	COG2982	Protein involved in outer membrane biogenesis
O165_RS19635	COG4221	oxidoreductase activity
O165_RS19665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O165_RS19670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O165_RS19685	COG1032	radical SAM domain protein
O165_RS19690	COG0305	Participates in initiation and elongation during chromosome replication
O165_RS19695	COG0359	binds to the 23S rRNA
O165_RS19705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O165_RS19710	COG0360	Binds together with S18 to 16S ribosomal RNA
O165_RS19715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O165_RS19720	COG0557	exoribonuclease II activity
O165_RS19735	COG1840	ABC-type Fe3 transport system, periplasmic component
O165_RS19740	COG1178	ABC-type Fe3 transport system permease component
O165_RS19745	COG0840	transmembrane signaling receptor activity
O165_RS19750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O165_RS19755	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O165_RS19760	COG0330	HflC and HflK could
O165_RS19765	COG0330	HflC and HflK could
O165_RS19770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O165_RS19775	COG1923	regulation of RNA biosynthetic process
O165_RS19780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O165_RS19785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O165_RS19790	COG0860	N-Acetylmuramoyl-L-alanine amidase
O165_RS19795	COG0802	atpase or kinase
O165_RS19800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O165_RS19800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O165_RS19810	COG2860	membrane
O165_RS19815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O165_RS19820	COG1162	GTPase activity
O165_RS19850	COG0688	phosphatidylethanolamine metabolic process
O165_RS19855	COG0560	Phosphoserine phosphatase
O165_RS19855	COG3830	Belongs to the UPF0237 family
O165_RS19875	COG3577	Aspartyl protease
O165_RS19890	COG3150	esterase
O165_RS19895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O165_RS19905	COG0494	nUDIX hydrolase
O165_RS19920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O165_RS19925	COG1538	Outer membrane efflux protein
O165_RS19930	COG1519	Transferase
O165_RS19935	COG0583	DNA-binding transcription factor activity
O165_RS19950	COG0667	Aldo Keto reductase
O165_RS19960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O165_RS19960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
O165_RS19965	COG1132	(ABC) transporter
O165_RS19980	COG0297	glycogen (starch) synthase activity
O165_RS20000	COG0438	transferase activity, transferring glycosyl groups
O165_RS20005	COG2192	nodulation
O165_RS20010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O165_RS20015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O165_RS20020	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
O165_RS20020	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
O165_RS20020	COG0506	proline dehydrogenase activity
O165_RS20025	COG4115	mRNA cleavage
O165_RS20030	COG2161	toxin-antitoxin pair type II binding
O165_RS20035	COG1960	acyl-CoA dehydrogenase activity
O165_RS20045	COG0312	modulator of DNA gyrase
O165_RS20050	COG0477	Major facilitator Superfamily
O165_RS20055	COG0513	Belongs to the DEAD box helicase family
O165_RS20060	COG2081	HI0933 family
O165_RS20065	COG1289	transmembrane transporter activity
O165_RS20075	COG2153	protein acetylation
O165_RS20085	COG1451	nucleotide metabolic process
O165_RS20090	COG5001	Diguanylate cyclase
O165_RS20090	COG3300	MHYT domain
O165_RS20110	COG0126	phosphoglycerate kinase activity
O165_RS20115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O165_RS20120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O165_RS20125	COG0640	Transcriptional regulator
O165_RS20130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O165_RS20135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O165_RS20175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
O165_RS20180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O165_RS20200	COG2353	YceI-like domain
O165_RS20205	COG3038	cytochrome b561
O165_RS20225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O165_RS20230	COG1272	protein, Hemolysin III
O165_RS20240	COG0784	Response regulator, receiver
O165_RS20240	COG0643	Histidine kinase
O165_RS20240	COG0784	Response regulator, receiver
O165_RS20240	COG2198	Histidine kinase
O165_RS20240	COG2198	Histidine kinase
O165_RS20240	COG0643	Histidine kinase
O165_RS20265	COG0189	ligase activity
O165_RS20275	COG1678	Uncharacterized ACR, COG1678
O165_RS20280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O165_RS20285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O165_RS20290	COG0540	Belongs to the ATCase OTCase family
O165_RS20295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O165_RS20300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O165_RS20305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O165_RS20350	COG2226	methyltransferase
O165_RS20360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O165_RS20365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O165_RS20370	COG0140	phosphoribosyl-ATP diphosphatase activity
O165_RS20375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O165_RS20380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O165_RS20395	COG0840	transmembrane signaling receptor activity
O165_RS20400	COG0840	transmembrane signaling receptor activity
O165_RS20405	COG1126	abc transporter atp-binding protein
O165_RS20410	COG0765	amino acid transport
O165_RS20420	COG2943	transferase activity, transferring hexosyl groups
O165_RS20425	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
O165_RS20430	COG1490	D-aminoacyl-tRNA deacylase activity
O165_RS20450	COG1228	amidohydrolase
O165_RS20460	COG2986	histidine ammonia-lyase
O165_RS20465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O165_RS20475	COG2188	Transcriptional regulator
O165_RS20480	COG0402	S-adenosylhomocysteine deaminase activity
O165_RS20505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
O165_RS20510	COG0058	SHG alpha-glucan phosphorylase activity
O165_RS20520	COG1217	gtp-binding protein TYPA
O165_RS20525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O165_RS20525	COG0301	tRNA thio-modification
O165_RS20540	COG3852	Histidine kinase
O165_RS20555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O165_RS20560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O165_RS20570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O165_RS20575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O165_RS20580	COG4942	peptidase
O165_RS20585	COG0793	Belongs to the peptidase S41A family
O165_RS20590	COG2861	carbohydrate metabolic process
O165_RS20595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O165_RS20600	COG1309	transcriptional regulator
O165_RS20605	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS20610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
O165_RS20615	COG3263	regulation of cellular component size
O165_RS20620	COG3264	Mechanosensitive ion channel
O165_RS20620	COG1196	nuclear chromosome segregation
O165_RS20625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O165_RS20630	COG3118	belongs to the thioredoxin family
O165_RS20645	COG1192	Involved in chromosome partitioning
O165_RS20660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O165_RS20665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O165_RS20690	COG2986	histidine ammonia-lyase
O165_RS20710	COG2226	methyltransferase
O165_RS20720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O165_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS20735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O165_RS20745	COG0583	DNA-binding transcription factor activity
O165_RS20750	COG2814	Major facilitator Superfamily
O165_RS20760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O165_RS20765	COG0493	'glutamate synthase
O165_RS20770	COG0067	glutamate synthase
O165_RS20770	COG0070	glutamate synthase
O165_RS20770	COG0069	glutamate synthase activity
O165_RS20780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O165_RS20785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O165_RS20815	COG0281	malic enzyme
O165_RS20825	COG0254	rRNA binding
O165_RS20830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O165_RS20835	COG0018	arginyl-trna synthetase
O165_RS20850	COG0791	NLP P60 protein
O165_RS20875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O165_RS20880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O165_RS20880	COG2813	Specifically methylates the guanine in position
O165_RS20890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O165_RS20895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O165_RS20905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O165_RS20910	COG2022	thiamine diphosphate biosynthetic process
O165_RS20920	COG2363	Small membrane protein
O165_RS20925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O165_RS20935	COG2177	Part of the ABC transporter FtsEX involved in
O165_RS20940	COG2884	Cell division ATP-binding protein ftsE
O165_RS20945	COG0552	protein localization to endoplasmic reticulum
O165_RS20950	COG0612	Peptidase, M16
O165_RS20955	COG0612	Peptidase, M16
O165_RS20960	COG0742	ribosomal rna small subunit methyltransferase
O165_RS20975	COG1309	transcriptional regulator
O165_RS20990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
O165_RS20995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O165_RS21000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O165_RS21005	COG0405	Gamma-glutamyltransferase
O165_RS21010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O165_RS21015	COG1639	'signal transduction protein
O165_RS21020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O165_RS21035	COG3246	L-lysine catabolic process to acetate
O165_RS21040	COG1250	3-hydroxyacyl-CoA dehydrogenase
O165_RS21060	COG1760	l-serine dehydratase
O165_RS21075	COG4176	ABC-type proline glycine betaine transport system permease component
O165_RS21080	COG4175	Glycine betaine
O165_RS21085	COG0107	imidazoleglycerol-phosphate synthase activity
O165_RS21090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O165_RS21100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O165_RS21105	COG0131	Imidazoleglycerol-phosphate dehydratase
O165_RS21110	COG2223	nitrite transmembrane transporter activity
O165_RS21125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
O165_RS21160	COG4215	(ABC) transporter
O165_RS21180	COG2076	Multidrug Resistance protein
O165_RS21190	COG3655	Transcriptional regulator
O165_RS21250	COG1840	ABC-type Fe3 transport system, periplasmic component
O165_RS21255	COG1178	ABC-type Fe3 transport system permease component
O165_RS21260	COG3842	ATPase activity
O165_RS21275	COG0789	Transcriptional regulator
O165_RS21280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O165_RS21285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O165_RS21290	COG0730	response to heat
O165_RS21300	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
O165_RS21305	COG0494	nUDIX hydrolase
O165_RS21315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O165_RS21320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O165_RS21325	COG3204	pilus organization
O165_RS21330	COG3204	pilus organization
O165_RS21335	COG0179	Fumarylacetoacetate (FAA) hydrolase
O165_RS21340	COG0277	FAD linked oxidase domain protein
O165_RS21345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O165_RS21365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS21370	COG1683	Conserved Protein
O165_RS21405	COG2267	carboxylic ester hydrolase activity
O165_RS21410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS21415	COG1126	abc transporter atp-binding protein
O165_RS21420	COG0765	amino acid transport
O165_RS21425	COG0765	amino acid transport
O165_RS21435	COG3829	transcription factor binding
O165_RS21460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O165_RS21465	COG4208	sulfate ABC transporter
O165_RS21475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O165_RS21485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS21495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS21505	COG1177	transmembrane transport
O165_RS21510	COG1176	ABC-type spermidine putrescine transport system, permease component I
O165_RS21515	COG3842	ATPase activity
O165_RS21535	COG0174	glutamine synthetase
O165_RS21540	COG0174	glutamine synthetase
O165_RS21545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O165_RS21545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O165_RS21560	COG1522	sequence-specific DNA binding
O165_RS21580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O165_RS21580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O165_RS21585	COG0509	glycine decarboxylation via glycine cleavage system
O165_RS21590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O165_RS21595	COG1178	ABC-type Fe3 transport system permease component
O165_RS21605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O165_RS21615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O165_RS21620	COG0006	proline dipeptidase activity
O165_RS21625	COG3079	Belongs to the UPF0149 family
O165_RS21640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O165_RS21650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS21655	COG0842	Transport permease protein
O165_RS21655	COG1129	ABC transporter
O165_RS21660	COG0842	Transport permease protein
O165_RS21690	COG1464	Belongs to the NlpA lipoprotein family
O165_RS21695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O165_RS21700	COG2011	ABC-type metal ion transport system permease component
O165_RS21715	COG2199	diguanylate cyclase activity
O165_RS21725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O165_RS21730	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS21740	COG4771	TonB-dependent receptor
O165_RS21760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O165_RS21845	COG0582	viral genome integration into host DNA
O165_RS21860	COG0517	IMP dehydrogenase activity
O165_RS21890	COG1280	lysine exporter protein (LysE YggA)
O165_RS21900	COG0488	(ABC) transporter
O165_RS21925	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O165_RS21945	COG0181	hydroxymethylbilane synthase activity
O165_RS21955	COG0165	Argininosuccinate lyase
O165_RS21960	COG0625	glutathione transferase activity
O165_RS21980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O165_RS21990	COG1965	Belongs to the frataxin family
O165_RS22000	COG0019	diaminopimelate decarboxylase activity
O165_RS22005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O165_RS22015	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O165_RS22020	COG0546	phosphoglycolate phosphatase activity
O165_RS22030	COG0004	ammonium transporteR
O165_RS22035	COG0347	Belongs to the P(II) protein family
O165_RS22060	COG0606	chelatase, subunit chli
O165_RS22085	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS22095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O165_RS22100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O165_RS22105	COG0747	negative chemotaxis
O165_RS22110	COG2003	Belongs to the UPF0758 family
O165_RS22115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O165_RS22120	COG0756	dUTP diphosphatase activity
O165_RS22125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O165_RS22130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O165_RS22140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O165_RS22145	COG0708	Exodeoxyribonuclease III
O165_RS22155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O165_RS22160	COG1561	YicC-like family, N-terminal region
O165_RS22165	COG0194	GDP metabolic process
O165_RS22175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O165_RS22180	COG0174	glutamine synthetase
O165_RS22190	COG1758	RNA polymerase activity
O165_RS22195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O165_RS22220	COG0848	biopolymer transport protein
O165_RS22230	COG0583	DNA-binding transcription factor activity
O165_RS22235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O165_RS22265	COG3161	chorismate lyase activity
O165_RS22270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O165_RS22290	COG1253	flavin adenine dinucleotide binding
O165_RS22295	COG0739	heme binding
O165_RS22305	COG0704	Plays a role in the regulation of phosphate uptake
O165_RS22310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O165_RS22315	COG0581	inorganic phosphate transmembrane transporter activity
O165_RS22335	COG1607	acyl-coa hydrolase
O165_RS22340	COG0676	glucose-6-phosphate 1-epimerase activity
O165_RS22365	COG0583	DNA-binding transcription factor activity
O165_RS22370	COG1027	Aspartate ammonia-lyase
O165_RS22410	COG0511	ligase activity, forming carbon-carbon bonds
O165_RS22410	COG5016	pyruvate
O165_RS22415	COG0439	Biotin carboxylase
O165_RS22420	COG0583	DNA-binding transcription factor activity
O165_RS22430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O165_RS22435	COG3300	MHYT domain
O165_RS22435	COG5001	Diguanylate cyclase
O165_RS22440	COG0210	DNA helicase
O165_RS22455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O165_RS22455	COG4651	solute:proton antiporter activity
O165_RS22460	COG1607	acyl-coa hydrolase
O165_RS22465	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O165_RS22475	COG0523	cobalamin synthesis protein
O165_RS22495	COG1469	GTP cyclohydrolase I activity
O165_RS22505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O165_RS22510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O165_RS22515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O165_RS22545	COG1247	-acetyltransferase
O165_RS22550	COG2072	flavoprotein involved in K transport
O165_RS22560	COG0431	NADPH-dependent FMN reductase
O165_RS22565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O165_RS22570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O165_RS22575	COG0640	Transcriptional regulator
O165_RS22595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O165_RS22605	COG0573	inorganic phosphate transmembrane transporter activity
O165_RS22610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O165_RS22630	COG3320	Male sterility
O165_RS22630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O165_RS22640	COG2197	response regulator
O165_RS22655	COG0464	growth
O165_RS22675	COG2433	Pfam Transposase IS66
O165_RS22680	COG0659	secondary active sulfate transmembrane transporter activity
O165_RS22710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS22775	COG1230	cation diffusion facilitator family transporter
O165_RS22790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O165_RS22800	COG0431	NADPH-dependent FMN reductase
O165_RS22805	COG0798	PFAM Bile acid sodium symporter
O165_RS22810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O165_RS22815	COG0640	Transcriptional regulator
O165_RS22855	COG0464	growth
O165_RS22880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O165_RS22885	COG1349	DNA-binding transcription factor activity
O165_RS22890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O165_RS22895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O165_RS22900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O165_RS22905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O165_RS22910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O165_RS22915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O165_RS22920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O165_RS22930	COG0356	it plays a direct role in the translocation of protons across the membrane
O165_RS22935	COG3312	ion transport
O165_RS22940	COG1475	DNA binding
O165_RS22945	COG1192	Involved in chromosome partitioning
O165_RS22950	COG0357	Ribosomal RNA small subunit methyltransferase G
O165_RS22955	COG0445	tRNA wobble uridine modification
O165_RS22960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O165_RS22965	COG0706	membrane insertase activity
O165_RS22970	COG0594	ribonuclease P activity
O165_RS22975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O165_RS22980	COG0592	DNA-directed DNA polymerase activity
O165_RS22985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O165_RS22990	COG0187	DNA topoisomerase II activity
O165_RS23070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS23145	COG2194	sulfuric ester hydrolase activity
O165_RS23195	COG0463	Glycosyl transferase, family 2
O165_RS23305	COG0477	Major facilitator Superfamily
O165_RS23315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O165_RS23320	COG0751	glycine-tRNA ligase activity
O165_RS23325	COG0752	glycyl-tRNA synthetase alpha subunit
O165_RS23330	COG2818	Glycosylase
O165_RS23345	COG0569	domain protein
O165_RS23350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O165_RS23355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O165_RS23360	COG0242	peptide deformylase activity
O165_RS23365	COG0758	DNA mediated transformation
O165_RS23370	COG0009	L-threonylcarbamoyladenylate synthase
O165_RS23385	COG0408	coproporphyrinogen oxidase activity
O165_RS23390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O165_RS23395	COG0659	secondary active sulfate transmembrane transporter activity
O165_RS23405	COG3119	arylsulfatase activity
O165_RS23420	COG0159	tryptophan synthase activity
O165_RS23425	COG0133	tryptophan synthase activity
O165_RS23440	COG3360	Dodecin
O165_RS23450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O165_RS23455	COG1764	response to oxidative stress
O165_RS23485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O165_RS23490	COG0339	signal peptide processing
O165_RS23495	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
O165_RS23500	COG0339	signal peptide processing
O165_RS23520	COG3039	Transposase
O165_RS23570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O165_RS23595	COG2433	Pfam Transposase IS66
O165_RS23605	COG0589	response to stress
O165_RS23610	COG0659	secondary active sulfate transmembrane transporter activity
O165_RS23660	COG0527	aspartate kinase activity
O165_RS23665	COG0156	8-amino-7-oxononanoate synthase activity
O165_RS23685	COG0477	Major facilitator Superfamily
O165_RS23690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS23705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O165_RS23710	COG2197	response regulator
O165_RS23715	COG3842	ATPase activity
O165_RS23720	COG1176	ABC-type spermidine putrescine transport system, permease component I
O165_RS23745	COG0183	Belongs to the thiolase family
O165_RS23750	COG1250	3-hydroxyacyl-CoA dehydrogenase
O165_RS23755	COG1024	Enoyl-CoA hydratase
O165_RS23765	COG1960	acyl-CoA dehydrogenase activity
O165_RS23770	COG0006	proline dipeptidase activity
O165_RS23830	COG0659	secondary active sulfate transmembrane transporter activity
O165_RS23840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O165_RS23845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O165_RS23850	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
O165_RS23875	COG1612	heme a metabolic process
O165_RS23880	COG0109	protoheme IX farnesyltransferase activity
O165_RS23890	COG1464	Belongs to the NlpA lipoprotein family
O165_RS23895	COG2011	ABC-type metal ion transport system permease component
O165_RS23900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O165_RS23915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O165_RS23920	COG1121	(ABC) transporter
O165_RS23925	COG0735	belongs to the Fur family
O165_RS23930	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O165_RS23950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O165_RS23955	COG3245	cytochrome
O165_RS23965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O165_RS23985	COG3023	N-Acetylmuramoyl-L-alanine amidase
O165_RS23990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
O165_RS23995	COG5002	protein histidine kinase activity
O165_RS24000	COG2204	response regulator
O165_RS24025	COG1301	dicarboxylic acid transport
O165_RS24030	COG0700	Nucleoside recognition
O165_RS24045	COG1127	ABC transporter
O165_RS24050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O165_RS24065	COG1283	sodium-dependent phosphate transmembrane transporter activity
O165_RS24070	COG0861	Integral membrane protein TerC family
O165_RS24075	COG2851	Citrate transporter
O165_RS24110	COG0534	Mate efflux family protein
O165_RS24120	COG0840	transmembrane signaling receptor activity
O165_RS24125	COG5383	Protein conserved in bacteria
O165_RS24130	COG0583	DNA-binding transcription factor activity
O165_RS24135	COG1012	belongs to the aldehyde dehydrogenase family
O165_RS24140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS24150	COG1335	isochorismatase
O165_RS24165	COG0583	DNA-binding transcription factor activity
O165_RS24170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O165_RS24175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O165_RS24185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS24205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O165_RS24210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O165_RS24225	COG0427	acetyl-CoA hydrolase
O165_RS24230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O165_RS24245	COG0427	acetyl-CoA hydrolase
O165_RS24265	COG0583	DNA-binding transcription factor activity
O165_RS24270	COG1960	acyl-CoA dehydrogenase activity
O165_RS24335	COG1802	Transcriptional regulator
O165_RS24345	COG3300	MHYT domain
O165_RS24345	COG5001	Diguanylate cyclase
O165_RS24375	COG2274	protein secretion by the type I secretion system
O165_RS24380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS24400	COG1289	transmembrane transporter activity
O165_RS24410	COG1566	PFAM secretion protein HlyD family protein
O165_RS24440	COG0672	)-iron permease
O165_RS24445	COG1671	Belongs to the UPF0178 family
O165_RS24450	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
O165_RS24470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O165_RS24475	COG0248	Ppx GppA phosphatase
O165_RS24490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O165_RS24505	COG1126	abc transporter atp-binding protein
O165_RS24510	COG0765	amino acid transport
O165_RS24515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS24520	COG1045	serine acetyltransferase
O165_RS24525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O165_RS24530	COG2175	clavaminate synthase activity
O165_RS24535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O165_RS24540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
O165_RS24545	COG4521	taurine ABC transporter
O165_RS24555	COG0450	alkyl hydroperoxide reductase
O165_RS24560	COG0431	NADPH-dependent FMN reductase
O165_RS24565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O165_RS24570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O165_RS24575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O165_RS24580	COG1116	anion transmembrane transporter activity
O165_RS24595	COG2918	glutathione biosynthetic process
O165_RS24605	COG2183	response to ionizing radiation
O165_RS24620	COG0189	ligase activity
O165_RS24625	COG0189	ligase activity
O165_RS24625	COG4067	protein conserved in archaea
O165_RS24630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O165_RS24640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O165_RS24645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O165_RS24655	COG2197	response regulator
O165_RS24660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O165_RS24670	COG0243	molybdopterin cofactor binding
O165_RS24675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O165_RS24680	COG1652	LysM domain
O165_RS24685	COG1011	Hydrolase
O165_RS24690	COG0494	nUDIX hydrolase
O165_RS24695	COG1218	3'(2'),5'-bisphosphate nucleotidase
O165_RS24715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O165_RS24720	COG1088	dTDP-glucose 4,6-dehydratase activity
O165_RS24725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O165_RS24730	COG2957	Belongs to the agmatine deiminase family
O165_RS24745	COG0069	glutamate synthase activity
O165_RS24755	COG3209	COG3209 Rhs family protein
O165_RS24820	COG0842	Transport permease protein
O165_RS24820	COG1131	(ABC) transporter
O165_RS24820	COG1716	ATPase activity
O165_RS24835	COG1360	Flagellar Motor Protein
O165_RS24855	COG2815	serine threonine protein kinase
O165_RS24855	COG0515	serine threonine protein kinase
O165_RS24860	COG0577	efflux transmembrane transporter activity
O165_RS24860	COG1136	(ABC) transporter
O165_RS24895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O165_RS24910	COG1823	symporter activity
O165_RS24920	COG0129	dihydroxy-acid dehydratase activity
O165_RS24945	COG0446	pyridine nucleotide-disulphide oxidoreductase
O165_RS24945	COG1902	pentaerythritol trinitrate reductase activity
O165_RS24950	COG0247	lactate metabolic process
O165_RS24950	COG2181	nitrate reductase activity
O165_RS24955	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O165_RS24970	COG4638	Rieske (2fe-2S)
O165_RS24975	COG1017	nitric oxide dioxygenase activity
O165_RS24975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O165_RS24995	COG0840	transmembrane signaling receptor activity
O165_RS25005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O165_RS25035	COG1063	alcohol dehydrogenase
O165_RS25050	COG0531	amino acid
O165_RS25055	COG0204	Acyl-transferase
O165_RS25065	COG0745	RESPONSE REGULATOR receiver
O165_RS25070	COG2205	protein histidine kinase activity
O165_RS25075	COG4452	Inner membrane protein CreD
O165_RS25085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O165_RS25105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O165_RS25120	COG0438	transferase activity, transferring glycosyl groups
O165_RS25155	COG4774	siderophore transport
O165_RS25160	COG3712	iron ion homeostasis
O165_RS25165	COG1595	DNA-templated transcription, initiation
O165_RS25170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O165_RS25185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O165_RS25205	COG3585	molybdate ion transport
O165_RS25205	COG2005	Transcriptional regulator
O165_RS25210	COG1040	competence protein
O165_RS25215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O165_RS25220	COG0156	8-amino-7-oxononanoate synthase activity
O165_RS25245	COG1960	acyl-CoA dehydrogenase activity
O165_RS25250	COG3706	GGDEF domain
O165_RS25255	COG1960	acyl-CoA dehydrogenase activity
O165_RS25260	COG0583	DNA-binding transcription factor activity
O165_RS25265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O165_RS25280	COG0535	radical SAM domain protein
O165_RS25290	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
O165_RS25295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O165_RS25300	COG1025	Belongs to the peptidase M16 family
O165_RS25305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O165_RS25315	COG2944	sequence-specific DNA binding
O165_RS25320	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
O165_RS25345	COG1690	Belongs to the RtcB family
O165_RS25350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O165_RS25370	COG0358	DNA primase activity
O165_RS25380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O165_RS25385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O165_RS25390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O165_RS25400	COG0617	tRNA 3'-terminal CCA addition
O165_RS25405	COG2719	SpoVR family
O165_RS25410	COG2718	Belongs to the UPF0229 family
O165_RS25415	COG2766	serine protein kinase
O165_RS25420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O165_RS25425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O165_RS25430	COG2967	ApaG domain
O165_RS25435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O165_RS25440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O165_RS25445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O165_RS25450	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O165_RS25455	COG3178	'Phosphotransferase
O165_RS25460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O165_RS25465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O165_RS25475	COG4585	Histidine kinase
O165_RS25480	COG2197	response regulator
O165_RS25485	COG3842	ATPase activity
O165_RS25495	COG1176	ABC-type spermidine putrescine transport system, permease component I
O165_RS25505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O165_RS25510	COG0546	phosphoglycolate phosphatase activity
O165_RS25515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O165_RS25520	COG4625	pathogenesis
O165_RS25520	COG3240	lipase activity
O165_RS25525	COG0512	Glutamine amidotransferase of anthranilate synthase
O165_RS25530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O165_RS25535	COG0134	indole-3-glycerol-phosphate synthase activity
O165_RS25550	COG1765	OsmC-like protein
O165_RS25565	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
O165_RS25570	COG0537	adenosine 5'-monophosphoramidase activity
O165_RS25575	COG0300	oxidoreductase activity
O165_RS25580	COG2070	2-Nitropropane dioxygenase
O165_RS25585	COG1981	membrane
O165_RS25590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O165_RS25595	COG0316	Belongs to the HesB IscA family
O165_RS25600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O165_RS25605	COG0739	heme binding
O165_RS25610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O165_RS25640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O165_RS25640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O165_RS25645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O165_RS25670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O165_RS25690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O165_RS25695	COG0081	regulation of translation
O165_RS25700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O165_RS25705	COG0222	ribosome binding
O165_RS25710	COG0085	RNA polymerase activity
O165_RS25715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O165_RS25720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O165_RS25725	COG0049	tRNA binding
O165_RS25730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O165_RS25735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O165_RS25745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O165_RS25750	COG0088	Forms part of the polypeptide exit tunnel
O165_RS25755	COG0089	rRNA binding
O165_RS25760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O165_RS25765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O165_RS25770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O165_RS25775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O165_RS25780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O165_RS25785	COG0255	Belongs to the universal ribosomal protein uL29 family
O165_RS25790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O165_RS25795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O165_RS25800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O165_RS25805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O165_RS25810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O165_RS25815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O165_RS25820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O165_RS25825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O165_RS25830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O165_RS25835	COG1841	ribosomal large subunit assembly
O165_RS25840	COG0200	Binds to the 23S rRNA
O165_RS25850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O165_RS25855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O165_RS25860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O165_RS25865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O165_RS25870	COG0202	RNA polymerase activity
O165_RS25875	COG0203	ribosomal protein L17
O165_RS25880	COG0753	catalase activity
O165_RS25885	COG2193	ferroxidase activity
O165_RS25890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O165_RS25895	COG2814	Major facilitator Superfamily
O165_RS25900	COG0629	single-stranded DNA binding
O165_RS25915	COG3383	formate dehydrogenase (NAD+) activity
O165_RS25915	COG0243	molybdopterin cofactor binding
O165_RS25920	COG3383	formate dehydrogenase (NAD+) activity
O165_RS25920	COG0243	molybdopterin cofactor binding
O165_RS25925	COG0437	4 iron, 4 sulfur cluster binding
O165_RS25930	COG2864	formate dehydrogenase
O165_RS25935	COG3058	Necessary for formate dehydrogenase activity
O165_RS25940	COG1921	L-seryl-tRNASec selenium transferase activity
O165_RS25945	COG3276	selenocysteine insertion sequence binding
O165_RS25955	COG0252	asparaginase activity
O165_RS25960	COG1115	amino acid carrier protein
O165_RS25980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O165_RS25990	COG2814	Major facilitator Superfamily
O165_RS25995	COG3047	cAMP biosynthetic process
O165_RS26010	COG1136	(ABC) transporter
O165_RS26010	COG0577	efflux transmembrane transporter activity
O165_RS26025	COG3118	belongs to the thioredoxin family
O165_RS26030	COG2264	protein methyltransferase activity
O165_RS26040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O165_RS26045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O165_RS26045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O165_RS26060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O165_RS26065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O165_RS26070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O165_RS26075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O165_RS26085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O165_RS26095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O165_RS26100	COG4206	TonB-dependent receptor
O165_RS26105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O165_RS26110	COG0142	geranyltranstransferase activity
O165_RS26115	COG1722	exodeoxyribonuclease VII activity
O165_RS26120	COG1696	Membrane protein involved in D-alanine export
O165_RS26135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O165_RS26140	COG4650	regulator
O165_RS26150	COG1690	Belongs to the RtcB family
O165_RS26160	COG3712	iron ion homeostasis
O165_RS26170	COG1629	transport
O165_RS26180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O165_RS26185	COG3228	Belongs to the MtfA family
O165_RS26190	COG0586	Pfam SNARE associated Golgi protein
O165_RS26195	COG0456	acetyltransferase
O165_RS26200	COG4302	ethanolamine ammonia-lyase activity
O165_RS26205	COG4303	Ethanolamine ammonia lyase large subunit
O165_RS26210	COG0531	amino acid
O165_RS26220	COG3284	Transcriptional regulator
O165_RS26225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O165_RS26240	COG0702	epimerase
O165_RS26260	COG1346	cytolysis
O165_RS26270	COG0586	Pfam SNARE associated Golgi protein
O165_RS26275	COG2094	Belongs to the DNA glycosylase MPG family
O165_RS26280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O165_RS26285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O165_RS26295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O165_RS26300	COG0768	penicillin binding
O165_RS26305	COG0772	Belongs to the SEDS family
O165_RS26310	COG2951	lytic endotransglycosylase activity
O165_RS26320	COG1686	Belongs to the peptidase S11 family
O165_RS26325	COG2921	Belongs to the UPF0250 family
O165_RS26330	COG0321	lipoyl(octanoyl) transferase activity
O165_RS26335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O165_RS26340	COG1619	proteins homologs of microcin C7 resistance protein MccF
O165_RS26345	COG2951	lytic endotransglycosylase activity
O165_RS26365	COG0495	leucyl-tRNA aminoacylation
O165_RS26380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O165_RS26385	COG4535	Mg2 and Co2 transporter CorC
O165_RS26390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O165_RS26395	COG1702	phosphate starvation-inducible protein PhoH
O165_RS26405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O165_RS26410	COG0352	thiamine-phosphate diphosphorylase activity
O165_RS26415	COG0351	phosphomethylpyrimidine kinase
O165_RS26420	COG0784	Response regulator, receiver
O165_RS26420	COG5002	protein histidine kinase activity
O165_RS26420	COG2205	protein histidine kinase activity
O165_RS26425	COG1960	acyl-CoA dehydrogenase activity
O165_RS26430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O165_RS26445	COG1522	sequence-specific DNA binding
O165_RS26475	COG1643	Atp-dependent helicase
O165_RS26485	COG3416	Protein conserved in bacteria
O165_RS26495	COG1522	sequence-specific DNA binding
O165_RS26500	COG0697	spore germination
O165_RS26505	COG0513	Belongs to the DEAD box helicase family
O165_RS26515	COG0123	including yeast histone deacetylase and acetoin utilization protein
O165_RS26530	COG1946	Acyl-CoA thioesterase
O165_RS26540	COG0604	alcohol dehydrogenase
O165_RS26540	COG3321	synthase
O165_RS26570	COG0189	ligase activity
O165_RS26570	COG0569	domain protein
O165_RS26585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS26610	COG1214	PFAM Peptidase M22, glycoprotease
O165_RS26610	COG0456	acetyltransferase
O165_RS26635	COG0529	Catalyzes the synthesis of activated sulfate
O165_RS26645	COG0583	DNA-binding transcription factor activity
O165_RS26650	COG0477	Major facilitator Superfamily
O165_RS26680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O165_RS26685	COG1074	ATP-dependent DNA helicase activity
O165_RS26690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O165_RS26700	COG2199	diguanylate cyclase activity
O165_RS26705	COG2885	chlorophyll binding
O165_RS26730	COG4589	Belongs to the CDS family
O165_RS26745	COG0671	phosphoesterase, PA-phosphatase related
O165_RS26745	COG2453	phosphatase
O165_RS26750	COG2267	carboxylic ester hydrolase activity
O165_RS26755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O165_RS26760	COG0534	Mate efflux family protein
O165_RS26765	COG2373	Large extracellular alpha-helical protein
O165_RS26775	COG4953	penicillin-binding protein 1C
O165_RS26790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O165_RS26795	COG2252	PERMEase
O165_RS26805	COG1271	oxidase subunit
O165_RS26810	COG1294	oxidase, subunit
O165_RS26820	COG2813	Specifically methylates the guanine in position
O165_RS26825	COG2197	response regulator
O165_RS26835	COG1970	mechanosensitive ion channel activity
O165_RS26850	COG2233	PERMEase
O165_RS26860	COG1966	Carbon starvation protein
O165_RS26865	COG2879	small protein
O165_RS26870	COG0523	cobalamin synthesis protein
O165_RS26885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O165_RS26900	COG0488	(ABC) transporter
O165_RS26905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O165_RS26910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O165_RS26930	COG1067	ATP-dependent peptidase activity
O165_RS26940	COG2862	Uncharacterized protein family, UPF0114
O165_RS26950	COG0545	Peptidyl-prolyl cis-trans isomerase
O165_RS26960	COG2824	Alkylphosphonate utilization operon protein PhnA
O165_RS26965	COG0142	geranyltranstransferase activity
O165_RS26970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O165_RS26975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O165_RS26980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O165_RS26985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O165_RS26990	COG3045	CreA protein
O165_RS27015	COG0456	acetyltransferase
O165_RS27050	COG2223	nitrite transmembrane transporter activity
O165_RS27055	COG3039	Transposase
O165_RS27070	COG3712	iron ion homeostasis
O165_RS27075	COG1595	DNA-templated transcription, initiation
O165_RS27085	COG2169	Transcriptional regulator
O165_RS27085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O165_RS27090	COG3264	Mechanosensitive ion channel
O165_RS27090	COG1511	domain protein
O165_RS27110	COG1335	isochorismatase
O165_RS27115	COG1335	isochorismatase
O165_RS27120	COG0583	DNA-binding transcription factor activity
O165_RS27125	COG2814	Major facilitator Superfamily
O165_RS27140	COG0193	aminoacyl-tRNA hydrolase activity
O165_RS27145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O165_RS27150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O165_RS27160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O165_RS27165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O165_RS27175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O165_RS27180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O165_RS27190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O165_RS27195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O165_RS27210	COG0789	Transcriptional regulator
O165_RS27220	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
O165_RS27225	COG1090	epimerase
O165_RS27230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O165_RS27240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O165_RS27245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O165_RS27265	COG0579	oxidoreductase
O165_RS27305	COG2135	peptidase activity
O165_RS27310	COG0840	transmembrane signaling receptor activity
O165_RS27320	COG2119	membrane
O165_RS27325	COG2813	Specifically methylates the guanine in position
O165_RS27330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O165_RS27335	COG0318	PFAM AMP-dependent synthetase and ligase
O165_RS27365	COG2336	PFAM SpoVT AbrB
O165_RS27370	COG2337	Toxic component of a toxin-antitoxin (TA) module
O165_RS27375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O165_RS27380	COG2885	chlorophyll binding
O165_RS27385	COG2957	Belongs to the agmatine deiminase family
O165_RS27400	COG2957	Belongs to the agmatine deiminase family
O165_RS27410	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O165_RS27455	COG0583	DNA-binding transcription factor activity
O165_RS27460	COG1380	Effector of murein hydrolase LrgA
O165_RS27465	COG1346	cytolysis
O165_RS27470	COG0596	Alpha beta hydrolase
O165_RS27475	COG1028	Short-chain dehydrogenase reductase Sdr
O165_RS27485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O165_RS27550	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
O165_RS27555	COG0492	ferredoxin-NADP+ reductase activity
O165_RS27575	COG3725	Membrane protein required for beta-lactamase induction
O165_RS27580	COG0840	transmembrane signaling receptor activity
O165_RS27595	COG0084	hydrolase, TatD family'
O165_RS27600	COG1609	Transcriptional regulator
O165_RS27610	COG1105	Belongs to the carbohydrate kinase PfkB family
O165_RS27615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O165_RS27615	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O165_RS27615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O165_RS27620	COG3530	Putative quorum-sensing-regulated virulence factor
O165_RS27630	COG5001	Diguanylate cyclase
O165_RS27630	COG4251	negative regulation of phosphorylation
O165_RS27630	COG2203	Gaf domain
O165_RS27630	COG3706	GGDEF domain
O165_RS27655	COG5002	protein histidine kinase activity
O165_RS27665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS27670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS27690	COG0835	chemotaxis
O165_RS27690	COG0784	Response regulator, receiver
O165_RS27695	COG3604	Transcriptional regulator
O165_RS27700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O165_RS27700	COG1017	nitric oxide dioxygenase activity
O165_RS27705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O165_RS27710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O165_RS27715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O165_RS27720	COG1845	cytochrome c oxidase, subunit III
O165_RS27730	COG0109	protoheme IX farnesyltransferase activity
O165_RS27750	COG0436	Aminotransferase
O165_RS27755	COG0727	PFAM Uncharacterised protein family (UPF0153)
O165_RS27810	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
O165_RS27815	COG0709	Synthesizes selenophosphate from selenide and ATP
O165_RS27820	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
O165_RS27825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
O165_RS27830	COG3639	organic phosphonate transmembrane transporter activity
O165_RS27835	COG3639	organic phosphonate transmembrane transporter activity
O165_RS27840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O165_RS27845	COG0315	cyclic pyranopterin monophosphate synthase activity
O165_RS27850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O165_RS27860	COG0513	Belongs to the DEAD box helicase family
O165_RS27865	COG0400	carboxylic ester hydrolase activity
O165_RS27870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS27875	COG4597	amino acid ABC transporter
O165_RS27880	COG0765	amino acid transport
O165_RS27885	COG1126	abc transporter atp-binding protein
O165_RS27890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O165_RS27900	COG0175	sulfate reduction
O165_RS27910	COG1522	sequence-specific DNA binding
O165_RS27920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O165_RS27935	COG0180	Tryptophanyl-tRNA synthetase
O165_RS27940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O165_RS27950	COG0667	Aldo Keto reductase
O165_RS27955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O165_RS27960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O165_RS27965	COG0723	plastoquinol--plastocyanin reductase activity
O165_RS27970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O165_RS27975	COG2857	Cytochrome c1
O165_RS27980	COG0625	glutathione transferase activity
O165_RS27985	COG2969	positive regulation of protein catabolic process
O165_RS27995	COG2823	Periplasmic or secreted lipoprotein
O165_RS28000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O165_RS28005	COG0792	nuclease activity
O165_RS28010	COG3107	peptidoglycan biosynthetic process
O165_RS28020	COG2001	Belongs to the MraZ family
O165_RS28025	COG0275	rRNA processing
O165_RS28040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O165_RS28045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O165_RS28050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O165_RS28055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O165_RS28060	COG0772	Belongs to the SEDS family
O165_RS28065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O165_RS28070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O165_RS28075	COG1181	Belongs to the D-alanine--D-alanine ligase family
O165_RS28090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O165_RS28095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O165_RS28105	COG0653	protein targeting
O165_RS28110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O165_RS28120	COG0494	nUDIX hydrolase
O165_RS28125	COG2096	Adenosyltransferase
O165_RS28130	COG4191	Histidine kinase
O165_RS28130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O165_RS28140	COG1666	GTP binding
O165_RS28145	COG0668	transmembrane transport
O165_RS28180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O165_RS28185	COG0459	protein refolding
O165_RS28200	COG0642	Histidine kinase
O165_RS28210	COG3642	lipopolysaccharide core region biosynthetic process
O165_RS28220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O165_RS28235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O165_RS28240	COG0154	amidase activity
O165_RS28245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O165_RS28250	COG1077	Cell shape determining protein MreB Mrl
O165_RS28255	COG1792	Involved in formation and maintenance of cell shape
O165_RS28265	COG0424	maF-like protein
O165_RS28280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O165_RS28285	COG0312	modulator of DNA gyrase
O165_RS28290	COG3028	Belongs to the UPF0307 family
O165_RS28295	COG0312	modulator of DNA gyrase
O165_RS28325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O165_RS28330	COG1660	Displays ATPase and GTPase activities
O165_RS28340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O165_RS28345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O165_RS28350	COG1137	ATPase activity
O165_RS28355	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O165_RS28365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
O165_RS28375	COG1127	ABC transporter
O165_RS28380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O165_RS28385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O165_RS28405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O165_RS28410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O165_RS28415	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O165_RS28420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O165_RS28425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O165_RS28430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O165_RS28460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O165_RS28470	COG0583	DNA-binding transcription factor activity
O165_RS28475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O165_RS28585	COG1404	Belongs to the peptidase S8 family
O165_RS28615	COG1271	oxidase subunit
O165_RS28730	COG0653	protein targeting
O165_RS28780	COG0583	DNA-binding transcription factor activity
O165_RS28810	COG1515	deoxyribonuclease V activity
O165_RS29040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O165_RS29215	COG3130	regulation of translation
O165_RS29415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O165_RS29420	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O165_RS29515	COG0586	Pfam SNARE associated Golgi protein
O165_RS29565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O165_RS29570	COG0051	transcription antitermination factor activity, RNA binding
O165_RS29760	COG3210	domain, Protein