locus-tag	class	description
HKK55_RS00030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HKK55_RS00035	COG1074	ATP-dependent DNA helicase activity
HKK55_RS00040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKK55_RS00050	COG2199	diguanylate cyclase activity
HKK55_RS00110	COG2274	protein secretion by the type I secretion system
HKK55_RS00125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKK55_RS00140	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HKK55_RS00145	COG3483	tryptophan 2,3-dioxygenase activity
HKK55_RS00150	COG1113	amino acid transport
HKK55_RS00155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK55_RS00155	COG0543	2 iron, 2 sulfur cluster binding
HKK55_RS00160	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HKK55_RS00165	COG4638	Rieske (2fe-2S)
HKK55_RS00180	COG4948	Mandelate Racemase Muconate Lactonizing
HKK55_RS00185	COG4829	muconolactone delta-isomerase
HKK55_RS00190	COG3485	protocatechuate 3,4-dioxygenase
HKK55_RS00195	COG1522	sequence-specific DNA binding
HKK55_RS00205	COG1113	amino acid transport
HKK55_RS00210	COG0583	DNA-binding transcription factor activity
HKK55_RS00225	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK55_RS00230	COG0583	DNA-binding transcription factor activity
HKK55_RS00240	COG0659	secondary active sulfate transmembrane transporter activity
HKK55_RS00250	COG2610	gluconate transmembrane transporter activity
HKK55_RS00260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HKK55_RS00275	COG0840	transmembrane signaling receptor activity
HKK55_RS00295	COG0633	Ferredoxin
HKK55_RS00295	COG3217	Mosc domain protein beta barrel domain protein
HKK55_RS00310	COG0583	DNA-binding transcription factor activity
HKK55_RS00365	COG1620	l-lactate permease
HKK55_RS00370	COG2186	Transcriptional regulator
HKK55_RS00375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HKK55_RS00380	COG0733	neurotransmitter:sodium symporter activity
HKK55_RS00390	COG2914	Belongs to the UPF0125 (RnfH) family
HKK55_RS00395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKK55_RS00405	COG0497	DNA recombination
HKK55_RS00410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKK55_RS00415	COG0443	Heat shock 70 kDa protein
HKK55_RS00420	COG0484	heat shock protein binding
HKK55_RS00425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HKK55_RS00430	COG0505	Belongs to the CarA family
HKK55_RS00435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HKK55_RS00440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK55_RS00455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HKK55_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKK55_RS00470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK55_RS00475	COG0149	triose-phosphate isomerase activity
HKK55_RS00480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKK55_RS00495	COG0779	Required for maturation of 30S ribosomal subunits
HKK55_RS00500	COG0195	Participates in both transcription termination and antitermination
HKK55_RS00505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKK55_RS00510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKK55_RS00515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKK55_RS00520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKK55_RS00525	COG1185	polyribonucleotide nucleotidyltransferase activity
HKK55_RS00530	COG2823	Periplasmic or secreted lipoprotein
HKK55_RS00540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK55_RS00550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK55_RS00555	COG0166	Belongs to the GPI family
HKK55_RS00560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HKK55_RS00565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HKK55_RS00575	COG0617	tRNA 3'-terminal CCA addition
HKK55_RS00580	COG2204	response regulator
HKK55_RS00585	COG4191	Histidine kinase
HKK55_RS00595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK55_RS00610	COG1489	DNA binding
HKK55_RS00620	COG4558	Periplasmic binding protein
HKK55_RS00625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK55_RS00630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HKK55_RS00650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK55_RS00660	COG3098	single-species biofilm formation
HKK55_RS00665	COG0028	Belongs to the TPP enzyme family
HKK55_RS00675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKK55_RS00680	COG1183	phosphatidylcholine synthase activity
HKK55_RS00685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKK55_RS00690	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HKK55_RS00720	COG2995	paraquat-inducible protein a
HKK55_RS00725	COG2995	paraquat-inducible protein a
HKK55_RS00730	COG3008	intermembrane lipid transfer
HKK55_RS00755	COG0456	acetyltransferase
HKK55_RS00765	COG0288	reversible hydration of carbon dioxide
HKK55_RS00785	COG2031	fatty acid transporter
HKK55_RS00800	COG0477	Major facilitator Superfamily
HKK55_RS00865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKK55_RS00895	COG0405	Gamma-glutamyltransferase
HKK55_RS00975	COG0582	viral genome integration into host DNA
HKK55_RS00990	COG2223	nitrite transmembrane transporter activity
HKK55_RS01015	COG4792	protein secretion
HKK55_RS01075	COG0012	GTP binding
HKK55_RS01080	COG0193	aminoacyl-tRNA hydrolase activity
HKK55_RS01085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HKK55_RS01090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKK55_RS01100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HKK55_RS01105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HKK55_RS01115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HKK55_RS01120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKK55_RS01130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HKK55_RS01135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HKK55_RS01145	COG4221	oxidoreductase activity
HKK55_RS01150	COG0415	Belongs to the DNA photolyase family
HKK55_RS01155	COG0789	Transcriptional regulator
HKK55_RS01165	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HKK55_RS01170	COG1090	epimerase
HKK55_RS01190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK55_RS01200	COG0175	sulfate reduction
HKK55_RS01210	COG0204	Acyl-transferase
HKK55_RS01215	COG0857	belongs to the CobB CobQ family
HKK55_RS01215	COG0280	phosphate acetyltransferase
HKK55_RS01225	COG1047	Peptidyl-prolyl cis-trans
HKK55_RS01230	COG0386	Belongs to the glutathione peroxidase family
HKK55_RS01245	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HKK55_RS01250	COG0492	ferredoxin-NADP+ reductase activity
HKK55_RS01265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKK55_RS01270	COG0302	gtp cyclohydrolase
HKK55_RS01295	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK55_RS01310	COG0596	Alpha beta hydrolase
HKK55_RS01315	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS01330	COG2197	response regulator
HKK55_RS01340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HKK55_RS01345	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK55_RS01365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKK55_RS01390	COG0814	amino acid
HKK55_RS01395	COG1760	l-serine dehydratase
HKK55_RS01400	COG0583	DNA-binding transcription factor activity
HKK55_RS01410	COG4772	TonB-dependent receptor
HKK55_RS01415	COG3712	iron ion homeostasis
HKK55_RS01420	COG1595	DNA-templated transcription, initiation
HKK55_RS01455	COG4774	siderophore transport
HKK55_RS01465	COG2027	D-alanyl-D-alanine carboxypeptidase
HKK55_RS01475	COG0697	spore germination
HKK55_RS01480	COG3604	Transcriptional regulator
HKK55_RS01485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK55_RS01485	COG1017	nitric oxide dioxygenase activity
HKK55_RS01490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HKK55_RS01495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKK55_RS01500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKK55_RS01515	COG0109	protoheme IX farnesyltransferase activity
HKK55_RS01525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKK55_RS01575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS01580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS01585	COG1126	abc transporter atp-binding protein
HKK55_RS01595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK55_RS01600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS01605	COG3706	GGDEF domain
HKK55_RS01625	COG2853	Lipoprotein
HKK55_RS01630	COG0745	RESPONSE REGULATOR receiver
HKK55_RS01675	COG0745	RESPONSE REGULATOR receiver
HKK55_RS01720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HKK55_RS01725	COG0343	queuine tRNA-ribosyltransferase activity
HKK55_RS01730	COG1862	Preprotein translocase
HKK55_RS01745	COG3134	Outer membrane lipoprotein
HKK55_RS01760	COG1045	serine acetyltransferase
HKK55_RS01770	COG1104	cysteine desulfurase activity
HKK55_RS01780	COG0316	Belongs to the HesB IscA family
HKK55_RS01785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HKK55_RS01790	COG0443	Heat shock 70 kDa protein
HKK55_RS01795	COG0633	Ferredoxin
HKK55_RS01805	COG0105	UTP biosynthetic process
HKK55_RS01810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HKK55_RS01825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKK55_RS01830	COG0124	histidyl-tRNA synthetase
HKK55_RS01845	COG1160	GTP binding
HKK55_RS01850	COG0436	Aminotransferase
HKK55_RS01860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK55_RS01865	COG0739	heme binding
HKK55_RS01870	COG1570	exodeoxyribonuclease VII activity
HKK55_RS01895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKK55_RS01895	COG0519	Catalyzes the synthesis of GMP from XMP
HKK55_RS01905	COG2188	Transcriptional regulator
HKK55_RS01910	COG1263	PTS System
HKK55_RS01910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK55_RS01915	COG0366	Alpha amylase catalytic
HKK55_RS01920	COG4580	involved in the transport of maltose and maltodextrins
HKK55_RS01925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK55_RS01925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK55_RS01935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HKK55_RS01940	COG0047	phosphoribosylformylglycinamidine synthase activity
HKK55_RS01940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKK55_RS01945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKK55_RS01955	COG2190	(PTS) system
HKK55_RS01955	COG1263	PTS System
HKK55_RS01955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK55_RS01960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK55_RS01960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK55_RS01965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKK55_RS01970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKK55_RS01975	COG2188	Transcriptional regulator
HKK55_RS01990	COG0494	nUDIX hydrolase
HKK55_RS02010	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HKK55_RS02015	COG0477	Major facilitator Superfamily
HKK55_RS02020	COG4536	flavin adenine dinucleotide binding
HKK55_RS02030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKK55_RS02035	COG0228	four-way junction DNA binding
HKK55_RS02040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKK55_RS02045	COG0336	Belongs to the RNA methyltransferase TrmD family
HKK55_RS02050	COG0335	large ribosomal subunit rRNA binding
HKK55_RS02055	COG3263	regulation of cellular component size
HKK55_RS02060	COG4974	Belongs to the 'phage' integrase family
HKK55_RS02080	COG2205	protein histidine kinase activity
HKK55_RS02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS02085	COG2202	Pas domain
HKK55_RS02085	COG2200	EAL domain
HKK55_RS02085	COG2199	diguanylate cyclase activity
HKK55_RS02090	COG2197	response regulator
HKK55_RS02110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK55_RS02125	COG1902	pentaerythritol trinitrate reductase activity
HKK55_RS02135	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HKK55_RS02155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK55_RS02155	COG0457	Tetratricopeptide repeat
HKK55_RS02170	COG2201	protein-glutamate methylesterase activity
HKK55_RS02175	COG5001	Diguanylate cyclase
HKK55_RS02175	COG3706	GGDEF domain
HKK55_RS02175	COG2203	Gaf domain
HKK55_RS02175	COG4251	negative regulation of phosphorylation
HKK55_RS02185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKK55_RS02200	COG1073	alpha beta
HKK55_RS02230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKK55_RS02235	COG0563	adenylate kinase activity
HKK55_RS02240	COG1214	PFAM Peptidase M22, glycoprotease
HKK55_RS02250	COG1801	Protein of unknown function DUF72
HKK55_RS02265	COG0742	ribosomal rna small subunit methyltransferase
HKK55_RS02305	COG2937	Belongs to the GPAT DAPAT family
HKK55_RS02320	COG2226	methyltransferase
HKK55_RS02325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK55_RS02330	COG1215	transferase activity, transferring glycosyl groups
HKK55_RS02335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HKK55_RS02345	COG2166	iron-sulfur cluster assembly
HKK55_RS02350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKK55_RS02355	COG2171	N-acyltransferase activity
HKK55_RS02360	COG1393	Belongs to the ArsC family
HKK55_RS02365	COG0025	NhaP-type Na H and K H
HKK55_RS02375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HKK55_RS02380	COG0024	Methionine aminopeptidase
HKK55_RS02385	COG0052	Belongs to the universal ribosomal protein uS2 family
HKK55_RS02390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKK55_RS02395	COG0528	UMP kinase activity
HKK55_RS02400	COG0233	cytoplasmic translational termination
HKK55_RS02405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKK55_RS02415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HKK55_RS02435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK55_RS02440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKK55_RS02445	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK55_RS02450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK55_RS02455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKK55_RS02460	COG0587	DNA-directed DNA polymerase activity
HKK55_RS02465	COG0825	malonyl-CoA metabolic process
HKK55_RS02470	COG0037	tRNA processing
HKK55_RS02475	COG0504	CTP synthase activity
HKK55_RS02480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HKK55_RS02485	COG0148	phosphopyruvate hydratase activity
HKK55_RS02495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HKK55_RS02505	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HKK55_RS02510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HKK55_RS02515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HKK55_RS02520	COG0585	pseudouridine synthase activity
HKK55_RS02525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HKK55_RS02530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKK55_RS02545	COG1278	Cold shock
HKK55_RS02550	COG0717	Belongs to the dCTP deaminase family
HKK55_RS02585	COG2366	antibiotic biosynthetic process
HKK55_RS02590	COG0625	glutathione transferase activity
HKK55_RS02595	COG1335	isochorismatase
HKK55_RS02600	COG0653	protein targeting
HKK55_RS02610	COG3012	SEC-C Motif Domain Protein
HKK55_RS02640	COG1199	ATP-dependent helicase activity
HKK55_RS02660	COG0259	pyridoxamine-phosphate oxidase activity
HKK55_RS02680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK55_RS02690	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HKK55_RS02705	COG0583	DNA-binding transcription factor activity
HKK55_RS02720	COG3220	belongs to the UPF0276 family
HKK55_RS02775	COG0727	PFAM Uncharacterised protein family (UPF0153)
HKK55_RS02780	COG2271	Major facilitator Superfamily
HKK55_RS02785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKK55_RS02800	COG0306	phosphate transporter
HKK55_RS02810	COG1414	Transcriptional regulator
HKK55_RS02815	COG2814	Major facilitator Superfamily
HKK55_RS02820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKK55_RS02825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKK55_RS02830	COG0183	Belongs to the thiolase family
HKK55_RS02835	COG3485	protocatechuate 3,4-dioxygenase
HKK55_RS02840	COG3485	protocatechuate 3,4-dioxygenase
HKK55_RS02845	COG0477	Major facilitator Superfamily
HKK55_RS02855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK55_RS02860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK55_RS02890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS02895	COG1309	transcriptional regulator
HKK55_RS02905	COG1902	pentaerythritol trinitrate reductase activity
HKK55_RS02910	COG2814	Major facilitator Superfamily
HKK55_RS02950	COG1473	amidohydrolase
HKK55_RS02960	COG0154	amidase activity
HKK55_RS02975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK55_RS02985	COG1704	LemA family
HKK55_RS03005	COG0697	spore germination
HKK55_RS03010	COG1629	transport
HKK55_RS03025	COG3422	double-strand break repair
HKK55_RS03030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK55_RS03035	COG0235	Class ii aldolase
HKK55_RS03040	COG1396	sequence-specific DNA binding
HKK55_RS03050	COG1454	alcohol dehydrogenase
HKK55_RS03075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK55_RS03080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK55_RS03085	COG2271	Major facilitator Superfamily
HKK55_RS03130	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK55_RS03145	COG3938	Belongs to the proline racemase family
HKK55_RS03150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK55_RS03155	COG0531	amino acid
HKK55_RS03165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HKK55_RS03185	COG0583	DNA-binding transcription factor activity
HKK55_RS03210	COG3657	addiction module killer protein
HKK55_RS03220	COG2267	carboxylic ester hydrolase activity
HKK55_RS03250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKK55_RS03300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HKK55_RS03330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK55_RS03340	COG0425	Belongs to the sulfur carrier protein TusA family
HKK55_RS03350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKK55_RS03360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK55_RS03365	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HKK55_RS03370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK55_RS03375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HKK55_RS03390	COG0583	DNA-binding transcription factor activity
HKK55_RS03435	COG2807	transmembrane transport
HKK55_RS03440	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS03450	COG0583	DNA-binding transcription factor activity
HKK55_RS03455	COG2910	NAD(P)H-binding
HKK55_RS03465	COG0583	DNA-binding transcription factor activity
HKK55_RS03495	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HKK55_RS03505	COG0583	DNA-binding transcription factor activity
HKK55_RS03515	COG0174	glutamine synthetase
HKK55_RS03520	COG2194	sulfuric ester hydrolase activity
HKK55_RS03535	COG3100	YcgL domain-containing protein
HKK55_RS03540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK55_RS03555	COG2983	Belongs to the UPF0260 family
HKK55_RS03595	COG1770	oligopeptidase
HKK55_RS03605	COG0121	glutamine amidotransferase
HKK55_RS03615	COG0583	DNA-binding transcription factor activity
HKK55_RS03620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HKK55_RS03625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HKK55_RS03630	COG1984	allophanate hydrolase subunit 2
HKK55_RS03640	COG0542	response to heat
HKK55_RS03650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKK55_RS03670	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HKK55_RS03680	COG1643	Atp-dependent helicase
HKK55_RS03690	COG1595	DNA-templated transcription, initiation
HKK55_RS03710	COG0513	Belongs to the DEAD box helicase family
HKK55_RS03715	COG0668	transmembrane transport
HKK55_RS03725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK55_RS03750	COG1132	(ABC) transporter
HKK55_RS03755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKK55_RS03795	COG2996	Protein conserved in bacteria
HKK55_RS03800	COG1953	Uracil, thiamine, allantoin
HKK55_RS03810	COG0583	DNA-binding transcription factor activity
HKK55_RS03815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK55_RS03850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK55_RS03855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKK55_RS03860	COG3956	TIGRFAM MazG family protein
HKK55_RS03865	COG3122	Protein conserved in bacteria
HKK55_RS03880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKK55_RS03885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HKK55_RS03895	COG0628	permease
HKK55_RS03900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKK55_RS03905	COG0791	NLP P60 protein
HKK55_RS03910	COG0791	NLP P60 protein
HKK55_RS03925	COG1797	cobyrinic acid a,c-diamide synthase activity
HKK55_RS03930	COG0778	Nitroreductase
HKK55_RS03945	COG1492	cobalamin metabolic process
HKK55_RS03955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HKK55_RS03960	COG0406	alpha-ribazole phosphatase activity
HKK55_RS03965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HKK55_RS03970	COG1846	Transcriptional regulator
HKK55_RS03985	COG2067	long-chain fatty acid transport protein
HKK55_RS04010	COG0784	Response regulator, receiver
HKK55_RS04010	COG2205	protein histidine kinase activity
HKK55_RS04010	COG2198	Histidine kinase
HKK55_RS04015	COG2832	Protein of unknown function (DUF454)
HKK55_RS04025	COG0514	ATP-dependent DNA helicase (RecQ)
HKK55_RS04030	COG1846	Transcriptional regulator
HKK55_RS04035	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKK55_RS04070	COG2154	pterin-4-alpha-carbinolamine dehydratase
HKK55_RS04080	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HKK55_RS04085	COG4787	bacterial-type flagellum-dependent cell motility
HKK55_RS04095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HKK55_RS04100	COG1706	bacterial-type flagellum-dependent cell motility
HKK55_RS04110	COG1256	bacterial-type flagellum assembly
HKK55_RS04155	COG5002	protein histidine kinase activity
HKK55_RS04165	COG1677	Flagellar hook-basal body complex protein FliE
HKK55_RS04200	COG0745	RESPONSE REGULATOR receiver
HKK55_RS04295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HKK55_RS04300	COG0784	Response regulator, receiver
HKK55_RS04300	COG0643	Histidine kinase
HKK55_RS04300	COG2198	Histidine kinase
HKK55_RS04305	COG2201	protein-glutamate methylesterase activity
HKK55_RS04310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HKK55_RS04320	COG1192	Involved in chromosome partitioning
HKK55_RS04330	COG0835	chemotaxis
HKK55_RS04340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKK55_RS04350	COG4133	protoheme IX ABC transporter activity
HKK55_RS04370	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HKK55_RS04375	COG1138	Cytochrome C-type biogenesis protein
HKK55_RS04385	COG3088	subunit of a heme lyase
HKK55_RS04390	COG4235	cytochrome complex assembly
HKK55_RS04405	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HKK55_RS04410	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HKK55_RS04415	COG3639	organic phosphonate transmembrane transporter activity
HKK55_RS04420	COG2188	Transcriptional regulator
HKK55_RS04425	COG3624	Phosphonate C-P lyase system protein PhnG
HKK55_RS04435	COG3626	phosphonate metabolism
HKK55_RS04440	COG3627	carbon phosphorus lyase activity
HKK55_RS04445	COG4107	phosphonate C-P lyase system protein PhnK
HKK55_RS04450	COG4778	phosphonate C-P lyase system protein PhnL
HKK55_RS04455	COG3454	Phosphonate metabolism
HKK55_RS04460	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HKK55_RS04465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK55_RS04490	COG0583	DNA-binding transcription factor activity
HKK55_RS04505	COG2814	Major facilitator Superfamily
HKK55_RS04520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK55_RS04530	COG0469	pyruvate kinase activity
HKK55_RS04540	COG2084	Dehydrogenase
HKK55_RS04545	COG3622	Belongs to the hyi family
HKK55_RS04550	COG3960	tartronate-semialdehyde synthase activity
HKK55_RS04565	COG1309	transcriptional regulator
HKK55_RS04570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS04580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS04590	COG2354	Protein conserved in bacteria
HKK55_RS04595	COG1289	transmembrane transporter activity
HKK55_RS04600	COG2853	Lipoprotein
HKK55_RS04620	COG2113	Glycine betaine
HKK55_RS04625	COG3162	membrane
HKK55_RS04630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK55_RS04640	COG2009	succinate dehydrogenase
HKK55_RS04645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HKK55_RS04655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKK55_RS04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK55_RS04675	COG0045	succinate-CoA ligase (ADP-forming) activity
HKK55_RS04710	COG0326	Molecular chaperone. Has ATPase activity
HKK55_RS04720	COG1741	Belongs to the pirin family
HKK55_RS04745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKK55_RS04750	COG5002	protein histidine kinase activity
HKK55_RS04750	COG2205	protein histidine kinase activity
HKK55_RS04750	COG0784	Response regulator, receiver
HKK55_RS04765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HKK55_RS04780	COG1022	Amp-dependent synthetase and ligase
HKK55_RS04805	COG0628	permease
HKK55_RS04810	COG2205	protein histidine kinase activity
HKK55_RS04820	COG0284	orotidine-5'-phosphate decarboxylase activity
HKK55_RS04825	COG2130	NADP-dependent
HKK55_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS04840	COG0840	transmembrane signaling receptor activity
HKK55_RS04885	COG0811	peptide transport
HKK55_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKK55_RS04905	COG3540	Alkaline phosphatase
HKK55_RS04925	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS04935	COG0625	glutathione transferase activity
HKK55_RS04940	COG1131	(ABC) transporter
HKK55_RS04945	COG0842	Transport permease protein
HKK55_RS04975	COG2076	Multidrug Resistance protein
HKK55_RS04980	COG0385	Bile acid
HKK55_RS04985	COG2974	May be involved in recombination
HKK55_RS05015	COG0583	DNA-binding transcription factor activity
HKK55_RS05025	COG2010	Cytochrome c
HKK55_RS05030	COG0545	Peptidyl-prolyl cis-trans isomerase
HKK55_RS05055	COG2200	EAL domain
HKK55_RS05065	COG3321	synthase
HKK55_RS05065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKK55_RS05065	COG0604	alcohol dehydrogenase
HKK55_RS05065	COG4221	oxidoreductase activity
HKK55_RS05075	COG3842	ATPase activity
HKK55_RS05085	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK55_RS05105	COG1473	amidohydrolase
HKK55_RS05110	COG0668	transmembrane transport
HKK55_RS05120	COG1362	aminopeptidase activity
HKK55_RS05125	COG0564	pseudouridine synthase activity
HKK55_RS05130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HKK55_RS05135	COG2894	cell division
HKK55_RS05140	COG0850	regulation of cytokinetic process
HKK55_RS05145	COG1560	Kdo2-lipid A biosynthetic process
HKK55_RS05165	COG2233	PERMEase
HKK55_RS05175	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HKK55_RS05180	COG4266	Belongs to the allantoicase family
HKK55_RS05210	COG2252	PERMEase
HKK55_RS05220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS05225	COG0625	glutathione transferase activity
HKK55_RS05230	COG0583	DNA-binding transcription factor activity
HKK55_RS05235	COG2851	Citrate transporter
HKK55_RS05255	COG0302	gtp cyclohydrolase
HKK55_RS05260	COG2840	Smr protein MutS2
HKK55_RS05285	COG1073	alpha beta
HKK55_RS05290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKK55_RS05300	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HKK55_RS05305	COG2197	response regulator
HKK55_RS05315	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS05355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK55_RS05360	COG3089	Belongs to the UPF0270 family
HKK55_RS05370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKK55_RS05370	COG0189	ligase activity
HKK55_RS05375	COG0367	asparagine synthase
HKK55_RS05380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS05380	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HKK55_RS05390	COG2326	polyphosphate kinase activity
HKK55_RS05395	COG0183	Belongs to the thiolase family
HKK55_RS05400	COG0697	spore germination
HKK55_RS05405	COG0114	fumarate hydratase activity
HKK55_RS05415	COG0271	Belongs to the BolA IbaG family
HKK55_RS05435	COG5002	protein histidine kinase activity
HKK55_RS05435	COG5001	Diguanylate cyclase
HKK55_RS05445	COG3706	GGDEF domain
HKK55_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS05455	COG0546	phosphoglycolate phosphatase activity
HKK55_RS05460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKK55_RS05465	COG0402	S-adenosylhomocysteine deaminase activity
HKK55_RS05470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HKK55_RS05480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HKK55_RS05490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKK55_RS05495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKK55_RS05500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HKK55_RS05510	COG0776	regulation of translation
HKK55_RS05525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HKK55_RS05545	COG2244	polysaccharide biosynthetic process
HKK55_RS05550	COG0463	Glycosyl transferase, family 2
HKK55_RS05575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKK55_RS05580	COG1086	Polysaccharide biosynthesis protein
HKK55_RS05600	COG1555	photosystem II stabilization
HKK55_RS05630	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKK55_RS05640	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKK55_RS05645	COG2205	protein histidine kinase activity
HKK55_RS05650	COG0745	RESPONSE REGULATOR receiver
HKK55_RS05690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HKK55_RS05715	COG1131	(ABC) transporter
HKK55_RS05725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK55_RS05730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HKK55_RS05735	COG4181	ATPase activity
HKK55_RS05750	COG1376	ErfK ybiS ycfS ynhG family protein
HKK55_RS05780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKK55_RS05800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK55_RS05815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKK55_RS05820	COG1764	response to oxidative stress
HKK55_RS05825	COG1846	Transcriptional regulator
HKK55_RS05830	COG0583	DNA-binding transcription factor activity
HKK55_RS05840	COG0583	DNA-binding transcription factor activity
HKK55_RS05850	COG3214	Protein conserved in bacteria
HKK55_RS05855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HKK55_RS05875	COG3384	dioxygenase
HKK55_RS05880	COG0500	methyltransferase
HKK55_RS05885	COG0501	Belongs to the peptidase M48B family
HKK55_RS05890	COG0436	Aminotransferase
HKK55_RS05895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK55_RS05900	COG0386	Belongs to the glutathione peroxidase family
HKK55_RS05905	COG1846	Transcriptional regulator
HKK55_RS05920	COG1956	GAF domain-containing protein
HKK55_RS05925	COG2205	protein histidine kinase activity
HKK55_RS05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS05930	COG2197	response regulator
HKK55_RS05945	COG3300	MHYT domain
HKK55_RS05945	COG5001	Diguanylate cyclase
HKK55_RS05965	COG0004	ammonium transporteR
HKK55_RS05990	COG0746	molybdenum cofactor guanylyltransferase activity
HKK55_RS05995	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKK55_RS06000	COG0303	'Molybdopterin
HKK55_RS06005	COG1597	lipid kinase activity
HKK55_RS06010	COG2197	response regulator
HKK55_RS06015	COG3851	Histidine kinase
HKK55_RS06035	COG3123	guanosine phosphorylase activity
HKK55_RS06050	COG1024	Enoyl-CoA hydratase
HKK55_RS06055	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS06060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKK55_RS06110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKK55_RS06125	COG0642	Histidine kinase
HKK55_RS06130	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKK55_RS06145	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS06155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS06160	COG1063	alcohol dehydrogenase
HKK55_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS06175	COG1609	Transcriptional regulator
HKK55_RS06220	COG2186	Transcriptional regulator
HKK55_RS06235	COG0745	RESPONSE REGULATOR receiver
HKK55_RS06240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKK55_RS06245	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKK55_RS06285	COG1846	Transcriptional regulator
HKK55_RS06320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS06325	COG0577	efflux transmembrane transporter activity
HKK55_RS06325	COG1136	(ABC) transporter
HKK55_RS06340	COG1522	sequence-specific DNA binding
HKK55_RS06345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS06350	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS06355	COG3706	GGDEF domain
HKK55_RS06370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS06375	COG2814	Major facilitator Superfamily
HKK55_RS06380	COG0583	DNA-binding transcription factor activity
HKK55_RS06390	COG1335	isochorismatase
HKK55_RS06395	COG1335	isochorismatase
HKK55_RS06405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK55_RS06410	COG4773	Receptor
HKK55_RS06430	COG2226	methyltransferase
HKK55_RS06495	COG0174	glutamine synthetase
HKK55_RS06505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS06530	COG1177	transmembrane transport
HKK55_RS06535	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK55_RS06540	COG3842	ATPase activity
HKK55_RS06545	COG1414	Transcriptional regulator
HKK55_RS06555	COG0534	Mate efflux family protein
HKK55_RS06565	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS06570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS06575	COG0765	amino acid transport
HKK55_RS06580	COG1126	abc transporter atp-binding protein
HKK55_RS06585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKK55_RS06600	COG1595	DNA-templated transcription, initiation
HKK55_RS06610	COG4772	TonB-dependent receptor
HKK55_RS06630	COG2223	nitrite transmembrane transporter activity
HKK55_RS06640	COG0738	Major facilitator superfamily
HKK55_RS06645	COG3254	rhamnose metabolic process
HKK55_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS06660	COG4948	Mandelate Racemase Muconate Lactonizing
HKK55_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS06680	COG2186	Transcriptional regulator
HKK55_RS06685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKK55_RS06690	COG3501	Rhs element vgr protein
HKK55_RS06710	COG0402	S-adenosylhomocysteine deaminase activity
HKK55_RS06715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKK55_RS06720	COG1051	belongs to the nudix hydrolase family
HKK55_RS06725	COG0720	synthase
HKK55_RS06745	COG0745	RESPONSE REGULATOR receiver
HKK55_RS06750	COG2205	protein histidine kinase activity
HKK55_RS06755	COG0840	transmembrane signaling receptor activity
HKK55_RS06760	COG2056	Na+-H+ antiporter family
HKK55_RS06800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK55_RS06805	COG3132	Protein of unknown function, DUF480
HKK55_RS06815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HKK55_RS06825	COG0583	DNA-binding transcription factor activity
HKK55_RS06835	COG1253	flavin adenine dinucleotide binding
HKK55_RS06840	COG0709	Synthesizes selenophosphate from selenide and ATP
HKK55_RS06845	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HKK55_RS06850	COG0701	Predicted permease
HKK55_RS06860	COG0625	glutathione transferase activity
HKK55_RS06865	COG0384	phenazine biosynthesis protein PhzF
HKK55_RS06875	COG0113	porphobilinogen synthase activity
HKK55_RS06880	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS06910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKK55_RS06915	COG0583	DNA-binding transcription factor activity
HKK55_RS06925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKK55_RS06930	COG0517	IMP dehydrogenase activity
HKK55_RS06935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKK55_RS06940	COG0477	Major facilitator Superfamily
HKK55_RS06960	COG4335	DNA alkylation repair
HKK55_RS06965	COG0174	glutamine synthetase
HKK55_RS06990	COG1704	LemA family
HKK55_RS06995	COG2814	Major facilitator Superfamily
HKK55_RS07005	COG3237	CsbD-like
HKK55_RS07055	COG2423	ornithine cyclodeaminase activity
HKK55_RS07065	COG0456	acetyltransferase
HKK55_RS07070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKK55_RS07075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK55_RS07085	COG0022	dehydrogenase e1 component
HKK55_RS07090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKK55_RS07095	COG1522	sequence-specific DNA binding
HKK55_RS07105	COG0640	Transcriptional regulator
HKK55_RS07115	COG0730	response to heat
HKK55_RS07150	COG0577	efflux transmembrane transporter activity
HKK55_RS07150	COG1136	(ABC) transporter
HKK55_RS07155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS07180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKK55_RS07195	COG0587	DNA-directed DNA polymerase activity
HKK55_RS07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS07215	COG0577	efflux transmembrane transporter activity
HKK55_RS07215	COG1136	(ABC) transporter
HKK55_RS07220	COG1136	(ABC) transporter
HKK55_RS07220	COG0577	efflux transmembrane transporter activity
HKK55_RS07235	COG0583	DNA-binding transcription factor activity
HKK55_RS07245	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS07260	COG2814	Major facilitator Superfamily
HKK55_RS07320	COG2197	response regulator
HKK55_RS07325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS07325	COG2205	protein histidine kinase activity
HKK55_RS07335	COG0656	L-ascorbic acid biosynthetic process
HKK55_RS07350	COG4206	TonB-dependent receptor
HKK55_RS07355	COG0583	DNA-binding transcription factor activity
HKK55_RS07385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKK55_RS07385	COG0475	glutathione-regulated potassium exporter activity
HKK55_RS07510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKK55_RS07515	COG0583	DNA-binding transcription factor activity
HKK55_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS07535	COG5002	protein histidine kinase activity
HKK55_RS07540	COG0745	RESPONSE REGULATOR receiver
HKK55_RS07560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS07565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS07585	COG3718	enzyme involved in inositol metabolism
HKK55_RS07600	COG3962	Belongs to the TPP enzyme family
HKK55_RS07605	COG0673	inositol 2-dehydrogenase activity
HKK55_RS07610	COG1082	Xylose isomerase domain protein TIM barrel
HKK55_RS07615	COG0673	inositol 2-dehydrogenase activity
HKK55_RS07630	COG1129	ABC transporter
HKK55_RS07635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS07675	COG4774	siderophore transport
HKK55_RS07690	COG0154	amidase activity
HKK55_RS07695	COG1349	DNA-binding transcription factor activity
HKK55_RS07700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK55_RS07730	COG3284	Transcriptional regulator
HKK55_RS07735	COG3842	ATPase activity
HKK55_RS07740	COG3842	ATPase activity
HKK55_RS07750	COG0395	ABC-type sugar transport system, permease component
HKK55_RS07775	COG1007	ATP synthesis coupled electron transport
HKK55_RS07790	COG0713	ATP synthesis coupled electron transport
HKK55_RS07800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK55_RS07805	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HKK55_RS07810	COG1034	ATP synthesis coupled electron transport
HKK55_RS07825	COG0649	NAD binding
HKK55_RS07825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK55_RS07830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK55_RS07835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK55_RS07850	COG2153	protein acetylation
HKK55_RS07855	COG2850	peptidyl-arginine hydroxylation
HKK55_RS07865	COG2915	High frequency lysogenization protein hflD homolog
HKK55_RS07870	COG0482	sulfurtransferase activity
HKK55_RS07895	COG1278	Cold shock
HKK55_RS07900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HKK55_RS07905	COG0542	response to heat
HKK55_RS07910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKK55_RS07915	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HKK55_RS07920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HKK55_RS07925	COG1674	ftsk spoiiie
HKK55_RS07930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HKK55_RS07935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKK55_RS07940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKK55_RS07945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKK55_RS07950	COG1648	precorrin-2 dehydrogenase activity
HKK55_RS07950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKK55_RS07955	COG0435	Glutathione S-transferase
HKK55_RS07960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKK55_RS07965	COG2920	part of a sulfur-relay system
HKK55_RS08040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKK55_RS08125	COG0590	tRNA wobble adenosine to inosine editing
HKK55_RS08145	COG0583	DNA-binding transcription factor activity
HKK55_RS08190	COG2814	Major facilitator Superfamily
HKK55_RS08220	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK55_RS08245	COG5001	Diguanylate cyclase
HKK55_RS08245	COG2203	Gaf domain
HKK55_RS08245	COG4251	negative regulation of phosphorylation
HKK55_RS08245	COG3706	GGDEF domain
HKK55_RS08310	COG0673	inositol 2-dehydrogenase activity
HKK55_RS08325	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK55_RS08325	COG1902	pentaerythritol trinitrate reductase activity
HKK55_RS08330	COG0235	Class ii aldolase
HKK55_RS08340	COG1024	Enoyl-CoA hydratase
HKK55_RS08345	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS08365	COG0601	transmembrane transport
HKK55_RS08380	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK55_RS08400	COG0656	L-ascorbic acid biosynthetic process
HKK55_RS08430	COG0631	protein serine/threonine phosphatase activity
HKK55_RS08455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKK55_RS08475	COG2267	carboxylic ester hydrolase activity
HKK55_RS08480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS08505	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS08520	COG0183	Belongs to the thiolase family
HKK55_RS08525	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS08530	COG0673	inositol 2-dehydrogenase activity
HKK55_RS08555	COG2706	6-phosphogluconolactonase activity
HKK55_RS08580	COG0420	3'-5' exonuclease activity
HKK55_RS08615	COG0714	Associated with various cellular activities
HKK55_RS08645	COG2818	Glycosylase
HKK55_RS08660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK55_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS08680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK55_RS08690	COG0814	amino acid
HKK55_RS08705	COG0589	response to stress
HKK55_RS08720	COG0745	RESPONSE REGULATOR receiver
HKK55_RS08725	COG2205	protein histidine kinase activity
HKK55_RS08740	COG3791	Glutathione-dependent formaldehyde-activating
HKK55_RS08755	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HKK55_RS08760	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS08825	COG0697	spore germination
HKK55_RS08830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS08845	COG0626	cystathionine gamma-synthase activity
HKK55_RS08915	COG2814	Major facilitator Superfamily
HKK55_RS08920	COG0840	transmembrane signaling receptor activity
HKK55_RS09020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK55_RS09030	COG1024	Enoyl-CoA hydratase
HKK55_RS09035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK55_RS09040	COG2814	Major facilitator Superfamily
HKK55_RS09050	COG4608	Belongs to the ABC transporter superfamily
HKK55_RS09055	COG0444	Belongs to the ABC transporter superfamily
HKK55_RS09060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK55_RS09065	COG0601	transmembrane transport
HKK55_RS09070	COG0747	negative chemotaxis
HKK55_RS09075	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HKK55_RS09095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKK55_RS09100	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS09140	COG2814	Major facilitator Superfamily
HKK55_RS09170	COG1741	Belongs to the pirin family
HKK55_RS09185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HKK55_RS09190	COG0583	DNA-binding transcription factor activity
HKK55_RS09215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK55_RS09220	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS09230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK55_RS09250	COG0583	DNA-binding transcription factor activity
HKK55_RS09260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK55_RS09265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS09270	COG1116	anion transmembrane transporter activity
HKK55_RS09285	COG2207	Transcriptional regulator
HKK55_RS09295	COG1609	Transcriptional regulator
HKK55_RS09300	COG0673	inositol 2-dehydrogenase activity
HKK55_RS09310	COG2211	Major facilitator Superfamily
HKK55_RS09315	COG1522	sequence-specific DNA binding
HKK55_RS09325	COG2066	Belongs to the glutaminase family
HKK55_RS09340	COG0019	diaminopimelate decarboxylase activity
HKK55_RS09375	COG1309	transcriptional regulator
HKK55_RS09515	COG1403	HNH endonuclease
HKK55_RS09530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK55_RS09545	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK55_RS09550	COG1733	regulation of RNA biosynthetic process
HKK55_RS09565	COG0642	Histidine kinase
HKK55_RS09585	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK55_RS09585	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK55_RS09610	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS09615	COG2207	Transcriptional regulator
HKK55_RS09620	COG1505	serine-type exopeptidase activity
HKK55_RS09650	COG4214	carbohydrate transport
HKK55_RS09655	COG1129	ABC transporter
HKK55_RS09660	COG4213	ABC transporter substrate-binding protein
HKK55_RS09665	COG2115	Belongs to the xylose isomerase family
HKK55_RS09670	COG2207	Transcriptional regulator
HKK55_RS09670	COG1609	Transcriptional regulator
HKK55_RS09680	COG0765	amino acid transport
HKK55_RS09685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS09690	COG2186	Transcriptional regulator
HKK55_RS09710	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS09720	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS09725	COG1129	ABC transporter
HKK55_RS09730	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS09760	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS09825	COG0640	Transcriptional regulator
HKK55_RS09840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKK55_RS09865	COG0488	(ABC) transporter
HKK55_RS09875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HKK55_RS09925	COG3321	synthase
HKK55_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS09925	COG0604	alcohol dehydrogenase
HKK55_RS09930	COG2169	Transcriptional regulator
HKK55_RS09930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKK55_RS09960	COG2863	cytochrome
HKK55_RS09965	COG3258	Cytochrome c
HKK55_RS10030	COG2200	EAL domain
HKK55_RS10045	COG1522	sequence-specific DNA binding
HKK55_RS10050	COG0667	Aldo Keto reductase
HKK55_RS10070	COG0583	DNA-binding transcription factor activity
HKK55_RS10080	COG2271	Major facilitator Superfamily
HKK55_RS10085	COG3835	regulator
HKK55_RS10090	COG1929	Belongs to the glycerate kinase type-1 family
HKK55_RS10120	COG1595	DNA-templated transcription, initiation
HKK55_RS10125	COG3712	iron ion homeostasis
HKK55_RS10130	COG4206	TonB-dependent receptor
HKK55_RS10140	COG4166	transmembrane transport
HKK55_RS10145	COG4174	ABC transporter (Permease)
HKK55_RS10150	COG4239	(ABC) transporter, permease
HKK55_RS10155	COG4172	Belongs to the ABC transporter superfamily
HKK55_RS10165	COG0738	Major facilitator superfamily
HKK55_RS10175	COG1349	DNA-binding transcription factor activity
HKK55_RS10180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HKK55_RS10185	COG2995	paraquat-inducible protein a
HKK55_RS10190	COG2995	paraquat-inducible protein a
HKK55_RS10195	COG3008	intermembrane lipid transfer
HKK55_RS10205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS10210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS10255	COG3501	Rhs element vgr protein
HKK55_RS10290	COG0475	glutathione-regulated potassium exporter activity
HKK55_RS10295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKK55_RS10310	COG0826	peptidase U32
HKK55_RS10315	COG0583	DNA-binding transcription factor activity
HKK55_RS10320	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS10330	COG1070	Carbohydrate kinase
HKK55_RS10340	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS10345	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS10360	COG1309	transcriptional regulator
HKK55_RS10395	COG2308	Evidence 4 Homologs of previously reported genes of
HKK55_RS10410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK55_RS10425	COG0745	RESPONSE REGULATOR receiver
HKK55_RS10435	COG2267	carboxylic ester hydrolase activity
HKK55_RS10440	COG0513	Belongs to the DEAD box helicase family
HKK55_RS10455	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK55_RS10500	COG1113	amino acid transport
HKK55_RS10520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS10535	COG0210	DNA helicase
HKK55_RS10550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS10560	COG3321	synthase
HKK55_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS10560	COG0604	alcohol dehydrogenase
HKK55_RS10585	COG0745	RESPONSE REGULATOR receiver
HKK55_RS10590	COG0745	RESPONSE REGULATOR receiver
HKK55_RS10595	COG0642	Histidine kinase
HKK55_RS10600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS10615	COG2207	Transcriptional regulator
HKK55_RS10620	COG0672	)-iron permease
HKK55_RS10625	COG2822	iron ion transport
HKK55_RS10635	COG2822	iron ion transport
HKK55_RS10645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK55_RS10660	COG2133	pyrroloquinoline quinone binding
HKK55_RS10670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HKK55_RS10695	COG0500	methyltransferase
HKK55_RS10700	COG0488	(ABC) transporter
HKK55_RS10715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK55_RS10735	COG1968	undecaprenyl-diphosphatase activity
HKK55_RS10740	COG0840	transmembrane signaling receptor activity
HKK55_RS10755	COG1024	Enoyl-CoA hydratase
HKK55_RS10760	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS10780	COG1238	metal cluster binding
HKK55_RS10800	COG0596	Alpha beta hydrolase
HKK55_RS10805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK55_RS10810	COG0297	glycogen (starch) synthase activity
HKK55_RS10815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKK55_RS10820	COG1640	4-alpha-glucanotransferase
HKK55_RS10865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKK55_RS10885	COG0348	domain, Protein
HKK55_RS10890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS10910	COG1538	Outer membrane efflux protein
HKK55_RS10915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS10955	COG3278	Belongs to the heme-copper respiratory oxidase family
HKK55_RS10970	COG1794	racemase activity, acting on amino acids and derivatives
HKK55_RS10975	COG1247	-acetyltransferase
HKK55_RS10980	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKK55_RS10990	COG0542	response to heat
HKK55_RS11000	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HKK55_RS11000	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HKK55_RS11010	COG0463	Glycosyl transferase, family 2
HKK55_RS11015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK55_RS11015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK55_RS11020	COG0726	polysaccharide deacetylase
HKK55_RS11025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKK55_RS11030	COG2076	Multidrug Resistance protein
HKK55_RS11035	COG2076	Multidrug Resistance protein
HKK55_RS11060	COG2366	antibiotic biosynthetic process
HKK55_RS11075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS11080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK55_RS11085	COG1116	anion transmembrane transporter activity
HKK55_RS11105	COG0583	DNA-binding transcription factor activity
HKK55_RS11110	COG0667	Aldo Keto reductase
HKK55_RS11115	COG1024	Enoyl-CoA hydratase
HKK55_RS11120	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS11135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK55_RS11140	COG3781	membrane
HKK55_RS11150	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HKK55_RS11165	COG2204	response regulator
HKK55_RS11170	COG0784	Response regulator, receiver
HKK55_RS11170	COG2205	protein histidine kinase activity
HKK55_RS11180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK55_RS11185	COG2198	Histidine kinase
HKK55_RS11185	COG0784	Response regulator, receiver
HKK55_RS11185	COG2205	protein histidine kinase activity
HKK55_RS11195	COG0745	RESPONSE REGULATOR receiver
HKK55_RS11210	COG1175	transmembrane transport
HKK55_RS11230	COG1070	Carbohydrate kinase
HKK55_RS11255	COG4574	serine-type endopeptidase inhibitor activity
HKK55_RS11260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKK55_RS11275	COG0598	Magnesium transport protein CorA
HKK55_RS11280	COG0189	ligase activity
HKK55_RS11290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK55_RS11305	COG2816	NAD+ diphosphatase activity
HKK55_RS11310	COG1024	Enoyl-CoA hydratase
HKK55_RS11315	COG2205	protein histidine kinase activity
HKK55_RS11320	COG0745	RESPONSE REGULATOR receiver
HKK55_RS11325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS11330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS11355	COG1609	Transcriptional regulator
HKK55_RS11365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK55_RS11385	COG0010	Belongs to the arginase family
HKK55_RS11400	COG2233	PERMEase
HKK55_RS11415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK55_RS11480	COG2204	response regulator
HKK55_RS11490	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK55_RS11495	COG0561	phosphatase activity
HKK55_RS11500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKK55_RS11505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HKK55_RS11515	COG2194	sulfuric ester hydrolase activity
HKK55_RS11550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK55_RS11565	COG0667	Aldo Keto reductase
HKK55_RS11580	COG0308	aminopeptidase N
HKK55_RS11590	COG3139	Protein of unknown function (DUF1315)
HKK55_RS11600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKK55_RS11605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKK55_RS11640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK55_RS11665	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HKK55_RS11665	COG0316	Belongs to the HesB IscA family
HKK55_RS11715	COG0028	Belongs to the TPP enzyme family
HKK55_RS11725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK55_RS11730	COG0431	NADPH-dependent FMN reductase
HKK55_RS11760	COG1982	Orn Lys Arg decarboxylase major
HKK55_RS11765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK55_RS11795	COG0328	RNA-DNA hybrid ribonuclease activity
HKK55_RS11805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKK55_RS11810	COG0741	lytic transglycosylase activity
HKK55_RS11810	COG1388	LysM domain
HKK55_RS11815	COG4166	transmembrane transport
HKK55_RS11820	COG4166	transmembrane transport
HKK55_RS11825	COG4174	ABC transporter (Permease)
HKK55_RS11830	COG4239	(ABC) transporter, permease
HKK55_RS11835	COG4172	Belongs to the ABC transporter superfamily
HKK55_RS11850	COG2186	Transcriptional regulator
HKK55_RS11875	COG0494	nUDIX hydrolase
HKK55_RS11880	COG1349	DNA-binding transcription factor activity
HKK55_RS11890	COG1304	FMN binding
HKK55_RS11940	COG1999	signal sequence binding
HKK55_RS11955	COG0165	Argininosuccinate lyase
HKK55_RS11960	COG1301	dicarboxylic acid transport
HKK55_RS11965	COG0583	DNA-binding transcription factor activity
HKK55_RS11985	COG2072	flavoprotein involved in K transport
HKK55_RS12010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKK55_RS12040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKK55_RS12060	COG2989	Protein conserved in bacteria
HKK55_RS12090	COG0625	glutathione transferase activity
HKK55_RS12095	COG0596	Alpha beta hydrolase
HKK55_RS12110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HKK55_RS12125	COG2010	Cytochrome c
HKK55_RS12125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK55_RS12130	COG2080	2 iron, 2 sulfur cluster binding
HKK55_RS12135	COG1846	Transcriptional regulator
HKK55_RS12140	COG2309	aminopeptidase activity
HKK55_RS12145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK55_RS12150	COG0596	Alpha beta hydrolase
HKK55_RS12155	COG3473	Maleate cis-trans isomerase
HKK55_RS12160	COG1335	isochorismatase
HKK55_RS12165	COG2271	Major facilitator Superfamily
HKK55_RS12170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKK55_RS12185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS12190	COG1116	anion transmembrane transporter activity
HKK55_RS12195	COG4774	siderophore transport
HKK55_RS12200	COG3712	iron ion homeostasis
HKK55_RS12205	COG1595	DNA-templated transcription, initiation
HKK55_RS12210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK55_RS12215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK55_RS12220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKK55_RS12230	COG4948	Mandelate Racemase Muconate Lactonizing
HKK55_RS12235	COG2271	Major facilitator Superfamily
HKK55_RS12240	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS12255	COG0583	DNA-binding transcription factor activity
HKK55_RS12260	COG0477	Major facilitator Superfamily
HKK55_RS12270	COG0667	Aldo Keto reductase
HKK55_RS12280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK55_RS12305	COG0730	response to heat
HKK55_RS12315	COG0038	chloride channel
HKK55_RS12320	COG3012	SEC-C Motif Domain Protein
HKK55_RS12320	COG3318	Belongs to the UPF0149 family
HKK55_RS12330	COG5507	3-demethylubiquinone-9 3-methyltransferase
HKK55_RS12335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKK55_RS12345	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK55_RS12380	COG3706	GGDEF domain
HKK55_RS12385	COG0596	Alpha beta hydrolase
HKK55_RS12420	COG3920	Histidine kinase
HKK55_RS12435	COG0563	adenylate kinase activity
HKK55_RS12450	COG2814	Major facilitator Superfamily
HKK55_RS12455	COG0583	DNA-binding transcription factor activity
HKK55_RS12545	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS12580	COG0673	inositol 2-dehydrogenase activity
HKK55_RS12600	COG1968	undecaprenyl-diphosphatase activity
HKK55_RS12615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKK55_RS12625	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKK55_RS12630	COG0583	DNA-binding transcription factor activity
HKK55_RS12650	COG2197	response regulator
HKK55_RS12670	COG3842	ATPase activity
HKK55_RS12685	COG0745	RESPONSE REGULATOR receiver
HKK55_RS12690	COG0642	Histidine kinase
HKK55_RS12695	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS12700	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HKK55_RS12705	COG0583	DNA-binding transcription factor activity
HKK55_RS12715	COG1522	sequence-specific DNA binding
HKK55_RS12720	COG1113	amino acid transport
HKK55_RS12725	COG1448	Aminotransferase
HKK55_RS12770	COG0604	alcohol dehydrogenase
HKK55_RS12775	COG0583	DNA-binding transcription factor activity
HKK55_RS12780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK55_RS12790	COG2149	membrane
HKK55_RS12795	COG0583	DNA-binding transcription factor activity
HKK55_RS12805	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS12810	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS12835	COG4447	cellulose binding
HKK55_RS12840	COG2409	Drug exporters of the RND superfamily
HKK55_RS12850	COG4160	amino acid transport
HKK55_RS12860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS12865	COG1473	amidohydrolase
HKK55_RS12870	COG0583	DNA-binding transcription factor activity
HKK55_RS12890	COG1063	alcohol dehydrogenase
HKK55_RS12905	COG0069	glutamate synthase activity
HKK55_RS12910	COG1607	acyl-coa hydrolase
HKK55_RS12940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HKK55_RS12945	COG0295	cytidine deaminase activity
HKK55_RS12960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS13000	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS13010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK55_RS13045	COG1231	oxidoreductase activity
HKK55_RS13050	COG1309	transcriptional regulator
HKK55_RS13070	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK55_RS13080	COG4774	siderophore transport
HKK55_RS13095	COG5001	Diguanylate cyclase
HKK55_RS13095	COG4251	negative regulation of phosphorylation
HKK55_RS13095	COG3706	GGDEF domain
HKK55_RS13095	COG2203	Gaf domain
HKK55_RS13105	COG1511	domain protein
HKK55_RS13105	COG3264	Mechanosensitive ion channel
HKK55_RS13120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HKK55_RS13130	COG0583	DNA-binding transcription factor activity
HKK55_RS13150	COG0322	excinuclease ABC activity
HKK55_RS13155	COG2197	response regulator
HKK55_RS13170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK55_RS13175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKK55_RS13180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK55_RS13190	COG4174	ABC transporter (Permease)
HKK55_RS13195	COG4239	(ABC) transporter, permease
HKK55_RS13200	COG4172	Belongs to the ABC transporter superfamily
HKK55_RS13205	COG3290	protein histidine kinase activity
HKK55_RS13205	COG3829	transcription factor binding
HKK55_RS13210	COG2610	gluconate transmembrane transporter activity
HKK55_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS13220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK55_RS13230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK55_RS13235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK55_RS13260	COG0765	amino acid transport
HKK55_RS13265	COG0765	amino acid transport
HKK55_RS13275	COG3118	belongs to the thioredoxin family
HKK55_RS13280	COG0384	phenazine biosynthesis protein PhzF
HKK55_RS13285	COG1253	flavin adenine dinucleotide binding
HKK55_RS13290	COG2390	Transcriptional regulator
HKK55_RS13295	COG0698	ribose 5-phosphate isomerase
HKK55_RS13300	COG1129	ABC transporter
HKK55_RS13305	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS13310	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS13320	COG1063	alcohol dehydrogenase
HKK55_RS13325	COG2376	Dihydroxyacetone kinase
HKK55_RS13335	COG0583	DNA-binding transcription factor activity
HKK55_RS13345	COG0616	signal peptide processing
HKK55_RS13365	COG5383	Protein conserved in bacteria
HKK55_RS13450	COG2111	Na H antiporter
HKK55_RS13450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKK55_RS13455	COG1006	Multisubunit Na H antiporter MnhC subunit
HKK55_RS13460	COG0651	ATP synthesis coupled electron transport
HKK55_RS13470	COG2212	antiporter activity
HKK55_RS13475	COG1320	monovalent cation:proton antiporter activity
HKK55_RS13480	COG0215	cysteine-tRNA ligase activity
HKK55_RS13485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK55_RS13495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK55_RS13500	COG2814	Major facilitator Superfamily
HKK55_RS13505	COG1566	PFAM secretion protein HlyD family protein
HKK55_RS13515	COG1846	Transcriptional regulator
HKK55_RS13520	COG2911	Protein conserved in bacteria
HKK55_RS13525	COG0729	surface antigen
HKK55_RS13535	COG0708	Exodeoxyribonuclease III
HKK55_RS13540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HKK55_RS13545	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS13555	COG0789	Transcriptional regulator
HKK55_RS13565	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS13570	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS13575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKK55_RS13600	COG2866	Carboxypeptidase
HKK55_RS13615	COG2814	Major facilitator Superfamily
HKK55_RS13620	COG3038	cytochrome b561
HKK55_RS13675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK55_RS13685	COG0217	transcriptional regulatory protein
HKK55_RS13700	COG0583	DNA-binding transcription factor activity
HKK55_RS13705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HKK55_RS13710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK55_RS13715	COG3038	cytochrome b561
HKK55_RS13725	COG1902	pentaerythritol trinitrate reductase activity
HKK55_RS13725	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK55_RS13745	COG0583	DNA-binding transcription factor activity
HKK55_RS13755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK55_RS13760	COG0776	regulation of translation
HKK55_RS13765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKK55_RS13770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKK55_RS13775	COG0740	serine-type endopeptidase activity
HKK55_RS13780	COG0544	peptidyl-prolyl cis-trans isomerase activity
HKK55_RS13805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKK55_RS13810	COG1686	Belongs to the peptidase S11 family
HKK55_RS13835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS13850	COG1953	Uracil, thiamine, allantoin
HKK55_RS13860	COG0493	'glutamate synthase
HKK55_RS13870	COG1309	transcriptional regulator
HKK55_RS13885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK55_RS13895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HKK55_RS13995	COG1538	Outer membrane efflux protein
HKK55_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS14010	COG3387	PFAM Glycoside hydrolase 15-related
HKK55_RS14020	COG4977	sequence-specific DNA binding
HKK55_RS14035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKK55_RS14090	COG0728	peptidoglycan biosynthetic process
HKK55_RS14120	COG0417	DNA replication proofreading
HKK55_RS14160	COG0768	penicillin binding
HKK55_RS14170	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS14175	COG0583	DNA-binding transcription factor activity
HKK55_RS14205	COG5006	permease, DMT superfamily
HKK55_RS14215	COG1309	transcriptional regulator
HKK55_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS14255	COG0431	NADPH-dependent FMN reductase
HKK55_RS14260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK55_RS14270	COG3829	transcription factor binding
HKK55_RS14290	COG2011	ABC-type metal ion transport system permease component
HKK55_RS14315	COG0583	DNA-binding transcription factor activity
HKK55_RS14325	COG0066	3-isopropylmalate dehydratase activity
HKK55_RS14330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKK55_RS14360	COG1121	(ABC) transporter
HKK55_RS14365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK55_RS14390	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS14395	COG3384	dioxygenase
HKK55_RS14405	COG2271	Major facilitator Superfamily
HKK55_RS14410	COG3971	2-oxopent-4-enoate hydratase activity
HKK55_RS14420	COG1846	Transcriptional regulator
HKK55_RS14425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS14450	COG3209	COG3209 Rhs family protein
HKK55_RS14480	COG0531	amino acid
HKK55_RS14490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKK55_RS14495	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS14500	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS14505	COG2771	luxR family
HKK55_RS14515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK55_RS14545	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS14550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HKK55_RS14560	COG0390	transport system, permease component
HKK55_RS14565	COG1122	ATPase activity
HKK55_RS14575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKK55_RS14580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKK55_RS14620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS14680	COG3646	Phage regulatory protein
HKK55_RS14835	COG1733	regulation of RNA biosynthetic process
HKK55_RS15055	COG0776	regulation of translation
HKK55_RS15060	COG0072	phenylalanine-tRNA ligase activity
HKK55_RS15065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKK55_RS15070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKK55_RS15075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HKK55_RS15080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKK55_RS15085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKK55_RS15095	COG1278	Cold shock
HKK55_RS15120	COG1869	D-ribose catabolic process
HKK55_RS15125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK55_RS15130	COG1609	Transcriptional regulator
HKK55_RS15135	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS15140	COG1129	ABC transporter
HKK55_RS15145	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS15170	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK55_RS15185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK55_RS15225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS15230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKK55_RS15230	COG3608	succinylglutamate desuccinylase aspartoacylase
HKK55_RS15235	COG2010	Cytochrome c
HKK55_RS15245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK55_RS15280	COG1286	toxin biosynthetic process
HKK55_RS15285	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKK55_RS15290	COG0285	dihydrofolate synthase activity
HKK55_RS15295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKK55_RS15300	COG0135	phosphoribosylanthranilate isomerase activity
HKK55_RS15330	COG0473	3-isopropylmalate dehydrogenase activity
HKK55_RS15335	COG2226	methyltransferase
HKK55_RS15340	COG0066	3-isopropylmalate dehydratase activity
HKK55_RS15345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKK55_RS15370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKK55_RS15380	COG0596	Alpha beta hydrolase
HKK55_RS15410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK55_RS15425	COG0556	nucleotide-excision repair
HKK55_RS15505	COG3011	Protein conserved in bacteria
HKK55_RS15525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS15530	COG4215	(ABC) transporter
HKK55_RS15550	COG1737	Transcriptional regulator
HKK55_RS15560	COG2384	SAM-dependent methyltransferase
HKK55_RS15565	COG3781	membrane
HKK55_RS15570	COG2814	Major facilitator Superfamily
HKK55_RS15575	COG1309	transcriptional regulator
HKK55_RS15600	COG0625	glutathione transferase activity
HKK55_RS15605	COG3663	DNA glycosylase
HKK55_RS15610	COG5001	Diguanylate cyclase
HKK55_RS15610	COG3300	MHYT domain
HKK55_RS15635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS15665	COG4774	siderophore transport
HKK55_RS15670	COG4607	ABC-type enterochelin transport system periplasmic component
HKK55_RS15675	COG4604	ABC transporter, ATP-binding protein
HKK55_RS15680	COG4605	iron ion homeostasis
HKK55_RS15685	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK55_RS15720	COG1169	isochorismate synthase
HKK55_RS15725	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKK55_RS15740	COG1944	ATP diphosphatase activity
HKK55_RS15785	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK55_RS15790	COG1024	Enoyl-CoA hydratase
HKK55_RS15800	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS15805	COG2814	Major facilitator Superfamily
HKK55_RS15815	COG2233	PERMEase
HKK55_RS15820	COG2814	Major facilitator Superfamily
HKK55_RS15825	COG0583	DNA-binding transcription factor activity
HKK55_RS15830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK55_RS15835	COG0583	DNA-binding transcription factor activity
HKK55_RS15845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HKK55_RS15855	COG1611	Belongs to the LOG family
HKK55_RS15860	COG0583	DNA-binding transcription factor activity
HKK55_RS15870	COG0251	oxidation-reduction process
HKK55_RS15900	COG0579	oxidoreductase
HKK55_RS15905	COG1309	transcriptional regulator
HKK55_RS15925	COG0789	Transcriptional regulator
HKK55_RS15930	COG2814	Major facilitator Superfamily
HKK55_RS15950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKK55_RS15955	COG1968	undecaprenyl-diphosphatase activity
HKK55_RS15975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKK55_RS15980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKK55_RS16005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKK55_RS16065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKK55_RS16085	COG2853	Lipoprotein
HKK55_RS16100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HKK55_RS16100	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HKK55_RS16120	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKK55_RS16125	COG1136	(ABC) transporter
HKK55_RS16130	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKK55_RS16140	COG0584	glycerophosphoryl diester phosphodiesterase
HKK55_RS16145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK55_RS16150	COG1477	protein flavinylation
HKK55_RS16165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKK55_RS16175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKK55_RS16220	COG0183	Belongs to the thiolase family
HKK55_RS16225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK55_RS16225	COG1024	Enoyl-CoA hydratase
HKK55_RS16235	COG0589	response to stress
HKK55_RS16245	COG0741	lytic transglycosylase activity
HKK55_RS16250	COG1132	(ABC) transporter
HKK55_RS16265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK55_RS16275	COG0425	Belongs to the sulfur carrier protein TusA family
HKK55_RS16280	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HKK55_RS16295	COG0840	transmembrane signaling receptor activity
HKK55_RS16305	COG3278	Belongs to the heme-copper respiratory oxidase family
HKK55_RS16320	COG2010	Cytochrome c
HKK55_RS16325	COG3278	Belongs to the heme-copper respiratory oxidase family
HKK55_RS16340	COG2010	Cytochrome c
HKK55_RS16355	COG0348	domain, Protein
HKK55_RS16390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK55_RS16395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKK55_RS16405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKK55_RS16410	COG2130	NADP-dependent
HKK55_RS16415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKK55_RS16420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKK55_RS16430	COG0840	transmembrane signaling receptor activity
HKK55_RS16450	COG0583	DNA-binding transcription factor activity
HKK55_RS16480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKK55_RS16485	COG3115	cell septum assembly
HKK55_RS16505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK55_RS16515	COG0402	S-adenosylhomocysteine deaminase activity
HKK55_RS16520	COG1802	Transcriptional regulator
HKK55_RS16525	COG3135	benzoate transporter
HKK55_RS16530	COG3171	Protein conserved in bacteria
HKK55_RS16540	COG3706	GGDEF domain
HKK55_RS16545	COG0116	Belongs to the methyltransferase superfamily
HKK55_RS16545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK55_RS16550	COG3130	regulation of translation
HKK55_RS16555	COG0167	dihydroorotate dehydrogenase activity
HKK55_RS16575	COG1116	anion transmembrane transporter activity
HKK55_RS16575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK55_RS16580	COG3707	response regulator
HKK55_RS16585	COG2223	nitrite transmembrane transporter activity
HKK55_RS16595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK55_RS16600	COG2146	nitrite reductase [NAD(P)H] activity
HKK55_RS16605	COG0243	molybdopterin cofactor binding
HKK55_RS16610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKK55_RS16615	COG2885	chlorophyll binding
HKK55_RS16615	COG3047	cAMP biosynthetic process
HKK55_RS16625	COG0668	transmembrane transport
HKK55_RS16635	COG0598	Magnesium transport protein CorA
HKK55_RS16640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKK55_RS16655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HKK55_RS16660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS16680	COG1045	serine acetyltransferase
HKK55_RS16685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKK55_RS16690	COG2079	MmgE PrpD family protein
HKK55_RS16700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKK55_RS16705	COG0372	Belongs to the citrate synthase family
HKK55_RS16715	COG1802	Transcriptional regulator
HKK55_RS16720	COG4067	protein conserved in archaea
HKK55_RS16720	COG0189	ligase activity
HKK55_RS16730	COG0189	ligase activity
HKK55_RS16740	COG0560	Phosphoserine phosphatase
HKK55_RS16750	COG1953	Uracil, thiamine, allantoin
HKK55_RS16760	COG0583	DNA-binding transcription factor activity
HKK55_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS16770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK55_RS16810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKK55_RS16815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKK55_RS16825	COG1063	alcohol dehydrogenase
HKK55_RS16855	COG3121	Chaperone
HKK55_RS16865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS16865	COG2205	protein histidine kinase activity
HKK55_RS16870	COG0784	Response regulator, receiver
HKK55_RS16870	COG2205	protein histidine kinase activity
HKK55_RS16875	COG2197	response regulator
HKK55_RS16885	COG2203	Gaf domain
HKK55_RS16885	COG4251	negative regulation of phosphorylation
HKK55_RS16885	COG5001	Diguanylate cyclase
HKK55_RS16885	COG3706	GGDEF domain
HKK55_RS16915	COG1132	(ABC) transporter
HKK55_RS16925	COG0312	modulator of DNA gyrase
HKK55_RS16950	COG4166	transmembrane transport
HKK55_RS16955	COG4174	ABC transporter (Permease)
HKK55_RS16960	COG4239	(ABC) transporter, permease
HKK55_RS16965	COG4172	Belongs to the ABC transporter superfamily
HKK55_RS16970	COG1511	domain protein
HKK55_RS16970	COG3264	Mechanosensitive ion channel
HKK55_RS16980	COG0183	Belongs to the thiolase family
HKK55_RS16985	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS17010	COG3008	intermembrane lipid transfer
HKK55_RS17015	COG2995	paraquat-inducible protein a
HKK55_RS17020	COG2995	paraquat-inducible protein a
HKK55_RS17030	COG4993	Dehydrogenase
HKK55_RS17100	COG0653	protein targeting
HKK55_RS17125	COG1475	DNA binding
HKK55_RS17165	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK55_RS17165	COG1024	Enoyl-CoA hydratase
HKK55_RS17175	COG0598	Magnesium transport protein CorA
HKK55_RS17180	COG0519	Catalyzes the synthesis of GMP from XMP
HKK55_RS17180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKK55_RS17185	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK55_RS17185	COG1024	Enoyl-CoA hydratase
HKK55_RS17190	COG0183	Belongs to the thiolase family
HKK55_RS17200	COG1305	Transglutaminase-like
HKK55_RS17210	COG2308	Evidence 4 Homologs of previously reported genes of
HKK55_RS17240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS17245	COG2885	chlorophyll binding
HKK55_RS17245	COG3047	cAMP biosynthetic process
HKK55_RS17275	COG2207	Transcriptional regulator
HKK55_RS17280	COG1064	alcohol dehydrogenase
HKK55_RS17285	COG1414	Transcriptional regulator
HKK55_RS17290	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK55_RS17295	COG1129	ABC transporter
HKK55_RS17300	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS17315	COG1418	mRNA catabolic process
HKK55_RS17340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK55_RS17350	COG1397	ADP-ribosylglycohydrolase
HKK55_RS17355	COG2188	Transcriptional regulator
HKK55_RS17370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKK55_RS17380	COG0084	hydrolase, TatD family'
HKK55_RS17390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKK55_RS17395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKK55_RS17405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK55_RS17410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK55_RS17425	COG0416	fatty acid biosynthetic process
HKK55_RS17430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HKK55_RS17440	COG0424	maF-like protein
HKK55_RS17445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK55_RS17445	COG0616	signal peptide processing
HKK55_RS17450	COG0546	phosphoglycolate phosphatase activity
HKK55_RS17460	COG1530	ribonuclease E activity
HKK55_RS17465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK55_RS17470	COG3608	succinylglutamate desuccinylase aspartoacylase
HKK55_RS17470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKK55_RS17485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HKK55_RS17490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK55_RS17495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HKK55_RS17500	COG2835	tetraacyldisaccharide 4'-kinase activity
HKK55_RS17505	COG1663	tetraacyldisaccharide 4'-kinase activity
HKK55_RS17510	COG0848	biopolymer transport protein
HKK55_RS17515	COG0811	peptide transport
HKK55_RS17520	COG0658	competence protein
HKK55_RS17520	COG2333	competence protein COMEC
HKK55_RS17540	COG2205	protein histidine kinase activity
HKK55_RS17540	COG5002	protein histidine kinase activity
HKK55_RS17540	COG0784	Response regulator, receiver
HKK55_RS17545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK55_RS17565	COG1393	Belongs to the ArsC family
HKK55_RS17585	COG0037	tRNA processing
HKK55_RS17595	COG3091	SprT-like family
HKK55_RS17600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK55_RS17610	COG1917	Cupin 2, conserved barrel domain protein
HKK55_RS17610	COG4977	sequence-specific DNA binding
HKK55_RS17620	COG0745	RESPONSE REGULATOR receiver
HKK55_RS17630	COG2977	Belongs to the P-Pant transferase superfamily
HKK55_RS17635	COG2205	protein histidine kinase activity
HKK55_RS17640	COG0745	RESPONSE REGULATOR receiver
HKK55_RS17655	COG1749	Flagellar hook protein flgE
HKK55_RS17670	COG1815	bacterial-type flagellum-dependent cell motility
HKK55_RS17675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK55_RS17680	COG0835	chemotaxis
HKK55_RS17680	COG0784	Response regulator, receiver
HKK55_RS17700	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HKK55_RS17705	COG0477	Major facilitator Superfamily
HKK55_RS17735	COG2239	Acts as a magnesium transporter
HKK55_RS17755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK55_RS17760	COG0527	aspartate kinase activity
HKK55_RS17765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKK55_RS17770	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HKK55_RS17775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HKK55_RS17780	COG2988	succinylglutamate desuccinylase activity
HKK55_RS17790	COG3724	N-succinylarginine dihydrolase activity
HKK55_RS17795	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS17810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK55_RS17840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS17855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK55_RS17870	COG1487	ribonuclease activity
HKK55_RS17885	COG0165	Argininosuccinate lyase
HKK55_RS17890	COG0765	amino acid transport
HKK55_RS17905	COG2814	Major facilitator Superfamily
HKK55_RS17920	COG4977	sequence-specific DNA binding
HKK55_RS17925	COG4221	oxidoreductase activity
HKK55_RS17930	COG0154	amidase activity
HKK55_RS17945	COG3706	GGDEF domain
HKK55_RS17960	COG0504	CTP synthase activity
HKK55_RS17970	COG0584	glycerophosphoryl diester phosphodiesterase
HKK55_RS17985	COG0306	phosphate transporter
HKK55_RS17990	COG1984	allophanate hydrolase subunit 2
HKK55_RS18010	COG0583	DNA-binding transcription factor activity
HKK55_RS18015	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS18035	COG0583	DNA-binding transcription factor activity
HKK55_RS18040	COG0583	DNA-binding transcription factor activity
HKK55_RS18045	COG4221	oxidoreductase activity
HKK55_RS18050	COG4941	Belongs to the sigma-70 factor family
HKK55_RS18060	COG3795	YCII-related domain
HKK55_RS18080	COG0436	Aminotransferase
HKK55_RS18090	COG3265	gluconokinase activity
HKK55_RS18095	COG1609	Transcriptional regulator
HKK55_RS18105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKK55_RS18110	COG2271	Major facilitator Superfamily
HKK55_RS18125	COG0583	DNA-binding transcription factor activity
HKK55_RS18130	COG0625	glutathione transferase activity
HKK55_RS18145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK55_RS18160	COG3712	iron ion homeostasis
HKK55_RS18165	COG1595	DNA-templated transcription, initiation
HKK55_RS18190	COG0242	peptide deformylase activity
HKK55_RS18195	COG1295	ribonuclease BN
HKK55_RS18215	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS18220	COG2267	carboxylic ester hydrolase activity
HKK55_RS18225	COG2030	dehydratase
HKK55_RS18235	COG3530	Putative quorum-sensing-regulated virulence factor
HKK55_RS18240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKK55_RS18245	COG0800	Aldolase
HKK55_RS18260	COG1737	Transcriptional regulator
HKK55_RS18265	COG0676	glucose-6-phosphate 1-epimerase activity
HKK55_RS18285	COG1175	transmembrane transport
HKK55_RS18290	COG1653	transport
HKK55_RS18295	COG2942	2-epimerase
HKK55_RS18305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK55_RS18310	COG0583	DNA-binding transcription factor activity
HKK55_RS18325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKK55_RS18340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKK55_RS18355	COG2271	Major facilitator Superfamily
HKK55_RS18385	COG1113	amino acid transport
HKK55_RS18405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKK55_RS18415	COG0009	L-threonylcarbamoyladenylate synthase
HKK55_RS18425	COG2917	probably involved in intracellular septation
HKK55_RS18430	COG2350	Protein conserved in bacteria
HKK55_RS18440	COG0745	RESPONSE REGULATOR receiver
HKK55_RS18450	COG0642	Histidine kinase
HKK55_RS18455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK55_RS18460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HKK55_RS18500	COG0509	glycine decarboxylation via glycine cleavage system
HKK55_RS18505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKK55_RS18505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKK55_RS18510	COG1760	l-serine dehydratase
HKK55_RS18515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK55_RS18520	COG1278	Cold shock
HKK55_RS18530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKK55_RS18535	COG0583	DNA-binding transcription factor activity
HKK55_RS18540	COG1304	FMN binding
HKK55_RS18560	COG0583	DNA-binding transcription factor activity
HKK55_RS18570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKK55_RS18575	COG0602	queuosine metabolic process
HKK55_RS18580	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HKK55_RS18585	COG2885	chlorophyll binding
HKK55_RS18590	COG0823	Involved in the tonB-independent uptake of proteins
HKK55_RS18610	COG0824	Thioesterase
HKK55_RS18615	COG2255	four-way junction helicase activity
HKK55_RS18620	COG0632	four-way junction helicase activity
HKK55_RS18625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HKK55_RS18630	COG0217	transcriptional regulatory protein
HKK55_RS18635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HKK55_RS18650	COG0783	Belongs to the Dps family
HKK55_RS18660	COG2900	Belongs to the SlyX family
HKK55_RS18675	COG0668	transmembrane transport
HKK55_RS18680	COG1666	GTP binding
HKK55_RS18690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS18690	COG4191	Histidine kinase
HKK55_RS18695	COG2096	Adenosyltransferase
HKK55_RS18705	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKK55_RS18710	COG0653	protein targeting
HKK55_RS18720	COG0433	COG0433 Predicted ATPase
HKK55_RS18745	COG2925	Exonuclease
HKK55_RS18770	COG0714	Associated with various cellular activities
HKK55_RS18790	COG0469	pyruvate kinase activity
HKK55_RS18795	COG1024	Enoyl-CoA hydratase
HKK55_RS18810	COG4191	Histidine kinase
HKK55_RS18820	COG0477	Major facilitator Superfamily
HKK55_RS18845	COG2207	Transcriptional regulator
HKK55_RS18855	COG0745	RESPONSE REGULATOR receiver
HKK55_RS18880	COG3712	iron ion homeostasis
HKK55_RS18885	COG4771	TonB-dependent receptor
HKK55_RS18895	COG2832	Protein of unknown function (DUF454)
HKK55_RS18900	COG0840	transmembrane signaling receptor activity
HKK55_RS18925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS18930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK55_RS18940	COG3642	lipopolysaccharide core region biosynthetic process
HKK55_RS18950	COG0642	Histidine kinase
HKK55_RS18960	COG1368	sulfuric ester hydrolase activity
HKK55_RS18970	COG0745	RESPONSE REGULATOR receiver
HKK55_RS18975	COG2205	protein histidine kinase activity
HKK55_RS18985	COG0459	protein refolding
HKK55_RS18990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKK55_RS19005	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS19020	COG2211	Major facilitator Superfamily
HKK55_RS19025	COG0442	prolyl-tRNA aminoacylation
HKK55_RS19035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKK55_RS19060	COG3158	transport of potassium into the cell
HKK55_RS19065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKK55_RS19070	COG0519	Catalyzes the synthesis of GMP from XMP
HKK55_RS19075	COG1187	pseudouridine synthase activity
HKK55_RS19080	COG4807	Protein conserved in bacteria
HKK55_RS19095	COG0583	DNA-binding transcription factor activity
HKK55_RS19125	COG2137	regulation of response to DNA damage stimulus
HKK55_RS19130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKK55_RS19135	COG1546	Belongs to the CinA family
HKK55_RS19140	COG3179	chitinase
HKK55_RS19235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HKK55_RS19245	COG0489	protein tyrosine kinase activity
HKK55_RS19250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK55_RS19250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK55_RS19255	COG4657	Part of a membrane complex involved in electron transport
HKK55_RS19260	COG2878	Part of a membrane complex involved in electron transport
HKK55_RS19265	COG4658	electron transport chain
HKK55_RS19280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKK55_RS19290	COG2197	response regulator
HKK55_RS19295	COG0137	argininosuccinate synthase activity
HKK55_RS19305	COG0418	dihydroorotase activity
HKK55_RS19310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK55_RS19320	COG0450	alkyl hydroperoxide reductase
HKK55_RS19335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKK55_RS19340	COG0243	molybdopterin cofactor binding
HKK55_RS19345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKK55_RS19350	COG3842	ATPase activity
HKK55_RS19355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKK55_RS19365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKK55_RS19380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS19385	COG0765	amino acid transport
HKK55_RS19390	COG0765	amino acid transport
HKK55_RS19395	COG1126	abc transporter atp-binding protein
HKK55_RS19400	COG4191	Histidine kinase
HKK55_RS19420	COG4191	Histidine kinase
HKK55_RS19435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK55_RS19460	COG2076	Multidrug Resistance protein
HKK55_RS19480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK55_RS19485	COG0583	DNA-binding transcription factor activity
HKK55_RS19495	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS19500	COG0494	nUDIX hydrolase
HKK55_RS19515	COG0254	rRNA binding
HKK55_RS19525	COG0069	glutamate synthase activity
HKK55_RS19545	COG1113	amino acid transport
HKK55_RS19580	COG4886	Leucine-rich repeat (LRR) protein
HKK55_RS19625	COG1695	Transcriptional regulator
HKK55_RS19630	COG2375	cellular response to nickel ion
HKK55_RS19640	COG4628	conserved protein (DUF2132)
HKK55_RS19645	COG4206	TonB-dependent receptor
HKK55_RS19670	COG0523	cobalamin synthesis protein
HKK55_RS19685	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS19705	COG1802	Transcriptional regulator
HKK55_RS19710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKK55_RS19725	COG2226	methyltransferase
HKK55_RS19730	COG0500	methyltransferase
HKK55_RS19735	COG0590	tRNA wobble adenosine to inosine editing
HKK55_RS19745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HKK55_RS19750	COG1381	Involved in DNA repair and RecF pathway recombination
HKK55_RS19755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKK55_RS19760	COG0571	ribonuclease III activity
HKK55_RS19765	COG0681	Belongs to the peptidase S26 family
HKK55_RS19770	COG0481	GTPase activity
HKK55_RS19775	COG0795	lipopolysaccharide-transporting ATPase activity
HKK55_RS19780	COG0795	lipopolysaccharide-transporting ATPase activity
HKK55_RS19785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKK55_RS19800	COG0525	valine-tRNA ligase activity
HKK55_RS19805	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HKK55_RS19815	COG3081	Nucleoid-associated protein
HKK55_RS19830	COG2827	Endonuclease containing a URI domain
HKK55_RS19840	COG2197	response regulator
HKK55_RS19845	COG0784	Response regulator, receiver
HKK55_RS19845	COG2205	protein histidine kinase activity
HKK55_RS19860	COG3539	Fimbrial protein
HKK55_RS19875	COG3121	Chaperone
HKK55_RS19880	COG3188	usher protein
HKK55_RS19885	COG3539	Fimbrial protein
HKK55_RS19890	COG3539	Fimbrial protein
HKK55_RS19895	COG2807	transmembrane transport
HKK55_RS19900	COG2186	Transcriptional regulator
HKK55_RS19910	COG1126	abc transporter atp-binding protein
HKK55_RS19915	COG0765	amino acid transport
HKK55_RS19920	COG4597	amino acid ABC transporter
HKK55_RS19925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS19930	COG0400	carboxylic ester hydrolase activity
HKK55_RS19935	COG0513	Belongs to the DEAD box helicase family
HKK55_RS19950	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HKK55_RS19955	COG0315	cyclic pyranopterin monophosphate synthase activity
HKK55_RS19965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HKK55_RS19980	COG3022	response to hydroperoxide
HKK55_RS19990	COG1215	transferase activity, transferring glycosyl groups
HKK55_RS19995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS20000	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HKK55_RS20010	COG3420	alginic acid biosynthetic process
HKK55_RS20025	COG1696	Membrane protein involved in D-alanine export
HKK55_RS20040	COG0662	Cupin 2, conserved barrel domain protein
HKK55_RS20040	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HKK55_RS20050	COG0300	oxidoreductase activity
HKK55_RS20070	COG1566	PFAM secretion protein HlyD family protein
HKK55_RS20095	COG0583	DNA-binding transcription factor activity
HKK55_RS20100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK55_RS20145	COG5002	protein histidine kinase activity
HKK55_RS20155	COG2203	Gaf domain
HKK55_RS20155	COG3706	GGDEF domain
HKK55_RS20155	COG4251	negative regulation of phosphorylation
HKK55_RS20155	COG5001	Diguanylate cyclase
HKK55_RS20160	COG3706	GGDEF domain
HKK55_RS20160	COG2203	Gaf domain
HKK55_RS20160	COG5001	Diguanylate cyclase
HKK55_RS20160	COG4251	negative regulation of phosphorylation
HKK55_RS20165	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HKK55_RS20170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKK55_RS20185	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKK55_RS20190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKK55_RS20195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKK55_RS20200	COG0772	Belongs to the SEDS family
HKK55_RS20205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKK55_RS20210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKK55_RS20215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKK55_RS20220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKK55_RS20235	COG0275	rRNA processing
HKK55_RS20240	COG2001	Belongs to the MraZ family
HKK55_RS20260	COG0792	nuclease activity
HKK55_RS20265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HKK55_RS20270	COG2823	Periplasmic or secreted lipoprotein
HKK55_RS20280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKK55_RS20300	COG0318	PFAM AMP-dependent synthetase and ligase
HKK55_RS20305	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS20310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK55_RS20315	COG2813	Specifically methylates the guanine in position
HKK55_RS20320	COG2119	membrane
HKK55_RS20325	COG0501	Belongs to the peptidase M48B family
HKK55_RS20330	COG2135	peptidase activity
HKK55_RS20395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKK55_RS20405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKK55_RS20410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKK55_RS20415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HKK55_RS20420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKK55_RS20440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKK55_RS20445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKK55_RS20450	COG1127	ABC transporter
HKK55_RS20460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HKK55_RS20470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HKK55_RS20475	COG1137	ATPase activity
HKK55_RS20480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HKK55_RS20485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKK55_RS20495	COG1660	Displays ATPase and GTPase activities
HKK55_RS20530	COG0312	modulator of DNA gyrase
HKK55_RS20535	COG3028	Belongs to the UPF0307 family
HKK55_RS20540	COG0312	modulator of DNA gyrase
HKK55_RS20545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK55_RS20555	COG1530	ribonuclease E activity
HKK55_RS20560	COG0424	maF-like protein
HKK55_RS20570	COG1792	Involved in formation and maintenance of cell shape
HKK55_RS20575	COG1077	Cell shape determining protein MreB Mrl
HKK55_RS20580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKK55_RS20585	COG0154	amidase activity
HKK55_RS20590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKK55_RS20595	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKK55_RS20605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK55_RS20615	COG2721	sulfolactate sulfo-lyase activity
HKK55_RS20620	COG2271	Major facilitator Superfamily
HKK55_RS20630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK55_RS20640	COG2186	Transcriptional regulator
HKK55_RS20645	COG2969	positive regulation of protein catabolic process
HKK55_RS20650	COG0625	glutathione transferase activity
HKK55_RS20655	COG2857	Cytochrome c1
HKK55_RS20660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HKK55_RS20665	COG0723	plastoquinol--plastocyanin reductase activity
HKK55_RS20670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HKK55_RS20675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKK55_RS20680	COG0667	Aldo Keto reductase
HKK55_RS20685	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS20695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK55_RS20700	COG0180	Tryptophanyl-tRNA synthetase
HKK55_RS20715	COG4178	(ABC) transporter
HKK55_RS20720	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HKK55_RS20740	COG0747	negative chemotaxis
HKK55_RS20745	COG0747	negative chemotaxis
HKK55_RS20750	COG0747	negative chemotaxis
HKK55_RS20760	COG0747	negative chemotaxis
HKK55_RS20765	COG0601	transmembrane transport
HKK55_RS20770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK55_RS20775	COG0444	Belongs to the ABC transporter superfamily
HKK55_RS20780	COG4608	Belongs to the ABC transporter superfamily
HKK55_RS20795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKK55_RS20820	COG0019	diaminopimelate decarboxylase activity
HKK55_RS20830	COG3128	pkhd-type hydroxylase
HKK55_RS20835	COG4774	siderophore transport
HKK55_RS20845	COG4774	siderophore transport
HKK55_RS20850	COG3712	iron ion homeostasis
HKK55_RS20865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HKK55_RS20865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK55_RS20865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK55_RS20870	COG1105	Belongs to the carbohydrate kinase PfkB family
HKK55_RS20880	COG1609	Transcriptional regulator
HKK55_RS20885	COG0084	hydrolase, TatD family'
HKK55_RS20905	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKK55_RS20950	COG0237	dephospho-CoA kinase activity
HKK55_RS20955	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HKK55_RS21005	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS21010	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS21025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKK55_RS21035	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HKK55_RS21045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKK55_RS21075	COG1252	NADH dehydrogenase
HKK55_RS21100	COG0542	response to heat
HKK55_RS21125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS21130	COG4969	Belongs to the N-Me-Phe pilin family
HKK55_RS21155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HKK55_RS21160	COG1047	Peptidyl-prolyl cis-trans
HKK55_RS21165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKK55_RS21170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKK55_RS21175	COG0196	riboflavin kinase activity
HKK55_RS21185	COG0268	Binds directly to 16S ribosomal RNA
HKK55_RS21190	COG3045	CreA protein
HKK55_RS21195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKK55_RS21200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKK55_RS21205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HKK55_RS21210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HKK55_RS21215	COG0142	geranyltranstransferase activity
HKK55_RS21220	COG2824	Alkylphosphonate utilization operon protein PhnA
HKK55_RS21225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK55_RS21230	COG0545	Peptidyl-prolyl cis-trans isomerase
HKK55_RS21235	COG2862	Uncharacterized protein family, UPF0114
HKK55_RS21250	COG1067	ATP-dependent peptidase activity
HKK55_RS21275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK55_RS21285	COG0488	(ABC) transporter
HKK55_RS21295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKK55_RS21300	COG0523	cobalamin synthesis protein
HKK55_RS21305	COG2879	small protein
HKK55_RS21310	COG1966	Carbon starvation protein
HKK55_RS21335	COG1970	mechanosensitive ion channel activity
HKK55_RS21345	COG2197	response regulator
HKK55_RS21350	COG2813	Specifically methylates the guanine in position
HKK55_RS21360	COG1294	oxidase, subunit
HKK55_RS21365	COG1271	oxidase subunit
HKK55_RS21380	COG2252	PERMEase
HKK55_RS21385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK55_RS21410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HKK55_RS21415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK55_RS21420	COG1309	transcriptional regulator
HKK55_RS21445	COG2321	neutral zinc metallopeptidase
HKK55_RS21460	COG1946	Acyl-CoA thioesterase
HKK55_RS21470	COG0123	including yeast histone deacetylase and acetoin utilization protein
HKK55_RS21475	COG2081	HI0933 family
HKK55_RS21480	COG0513	Belongs to the DEAD box helicase family
HKK55_RS21485	COG0697	spore germination
HKK55_RS21490	COG1522	sequence-specific DNA binding
HKK55_RS21515	COG1199	ATP-dependent helicase activity
HKK55_RS21515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK55_RS21525	COG3416	Protein conserved in bacteria
HKK55_RS21540	COG1643	Atp-dependent helicase
HKK55_RS21550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKK55_RS21560	COG1522	sequence-specific DNA binding
HKK55_RS21575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKK55_RS21580	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS21595	COG0352	thiamine-phosphate diphosphorylase activity
HKK55_RS21600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HKK55_RS21615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKK55_RS21620	COG1702	phosphate starvation-inducible protein PhoH
HKK55_RS21625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKK55_RS21630	COG4535	Mg2 and Co2 transporter CorC
HKK55_RS21635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HKK55_RS21650	COG0495	leucyl-tRNA aminoacylation
HKK55_RS21670	COG2951	lytic endotransglycosylase activity
HKK55_RS21675	COG1619	proteins homologs of microcin C7 resistance protein MccF
HKK55_RS21680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKK55_RS21685	COG0321	lipoyl(octanoyl) transferase activity
HKK55_RS21690	COG2921	Belongs to the UPF0250 family
HKK55_RS21695	COG1686	Belongs to the peptidase S11 family
HKK55_RS21705	COG2951	lytic endotransglycosylase activity
HKK55_RS21710	COG0772	Belongs to the SEDS family
HKK55_RS21715	COG0768	penicillin binding
HKK55_RS21720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HKK55_RS21730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKK55_RS21735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKK55_RS21740	COG2094	Belongs to the DNA glycosylase MPG family
HKK55_RS21745	COG0586	Pfam SNARE associated Golgi protein
HKK55_RS21760	COG1346	cytolysis
HKK55_RS21765	COG1380	Effector of murein hydrolase LrgA
HKK55_RS21780	COG0702	epimerase
HKK55_RS21795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKK55_RS21800	COG3284	Transcriptional regulator
HKK55_RS21805	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS21810	COG0531	amino acid
HKK55_RS21815	COG4303	Ethanolamine ammonia lyase large subunit
HKK55_RS21820	COG4302	ethanolamine ammonia-lyase activity
HKK55_RS21825	COG0456	acetyltransferase
HKK55_RS21830	COG0586	Pfam SNARE associated Golgi protein
HKK55_RS21835	COG3228	Belongs to the MtfA family
HKK55_RS21840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKK55_RS21875	COG3385	transposase activity
HKK55_RS21930	COG3188	usher protein
HKK55_RS21935	COG3121	Chaperone
HKK55_RS21970	COG0583	DNA-binding transcription factor activity
HKK55_RS21980	COG2197	response regulator
HKK55_RS21985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS21985	COG2205	protein histidine kinase activity
HKK55_RS21995	COG3188	usher protein
HKK55_RS22000	COG3121	Chaperone
HKK55_RS22010	COG5001	Diguanylate cyclase
HKK55_RS22010	COG3300	MHYT domain
HKK55_RS22025	COG3039	Transposase
HKK55_RS22035	COG3039	Transposase
HKK55_RS22045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS22045	COG2205	protein histidine kinase activity
HKK55_RS22055	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK55_RS22065	COG1722	exodeoxyribonuclease VII activity
HKK55_RS22070	COG0142	geranyltranstransferase activity
HKK55_RS22075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKK55_RS22080	COG4206	TonB-dependent receptor
HKK55_RS22085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKK55_RS22095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKK55_RS22105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HKK55_RS22110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKK55_RS22115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HKK55_RS22130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKK55_RS22130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKK55_RS22135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKK55_RS22145	COG2264	protein methyltransferase activity
HKK55_RS22150	COG3118	belongs to the thioredoxin family
HKK55_RS22190	COG1201	RNA secondary structure unwinding
HKK55_RS22195	COG2814	Major facilitator Superfamily
HKK55_RS22210	COG2207	Transcriptional regulator
HKK55_RS22210	COG4753	response regulator
HKK55_RS22215	COG1335	isochorismatase
HKK55_RS22220	COG4106	trans-aconitate 2-methyltransferase activity
HKK55_RS22225	COG0583	DNA-binding transcription factor activity
HKK55_RS22235	COG0629	single-stranded DNA binding
HKK55_RS22240	COG2814	Major facilitator Superfamily
HKK55_RS22245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKK55_RS22250	COG2193	ferroxidase activity
HKK55_RS22260	COG0203	ribosomal protein L17
HKK55_RS22265	COG0202	RNA polymerase activity
HKK55_RS22270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKK55_RS22275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKK55_RS22280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKK55_RS22285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKK55_RS22295	COG0200	Binds to the 23S rRNA
HKK55_RS22300	COG1841	ribosomal large subunit assembly
HKK55_RS22305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKK55_RS22310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKK55_RS22315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKK55_RS22320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKK55_RS22325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKK55_RS22330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKK55_RS22335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKK55_RS22340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKK55_RS22345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKK55_RS22350	COG0255	Belongs to the universal ribosomal protein uL29 family
HKK55_RS22355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKK55_RS22360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKK55_RS22365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKK55_RS22370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKK55_RS22375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKK55_RS22380	COG0089	rRNA binding
HKK55_RS22385	COG0088	Forms part of the polypeptide exit tunnel
HKK55_RS22390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKK55_RS22395	COG0051	transcription antitermination factor activity, RNA binding
HKK55_RS22400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKK55_RS22405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKK55_RS22410	COG0049	tRNA binding
HKK55_RS22415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKK55_RS22420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKK55_RS22425	COG0085	RNA polymerase activity
HKK55_RS22430	COG0222	ribosome binding
HKK55_RS22435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HKK55_RS22440	COG0081	regulation of translation
HKK55_RS22445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKK55_RS22485	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HKK55_RS22520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKK55_RS22525	COG0739	heme binding
HKK55_RS22530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HKK55_RS22535	COG0316	Belongs to the HesB IscA family
HKK55_RS22540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKK55_RS22560	COG4221	oxidoreductase activity
HKK55_RS22565	COG0537	adenosine 5'-monophosphoramidase activity
HKK55_RS22570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HKK55_RS22575	COG1765	OsmC-like protein
HKK55_RS22590	COG0134	indole-3-glycerol-phosphate synthase activity
HKK55_RS22595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKK55_RS22600	COG0512	Glutamine amidotransferase of anthranilate synthase
HKK55_RS22605	COG3240	lipase activity
HKK55_RS22605	COG4625	pathogenesis
HKK55_RS22615	COG0546	phosphoglycolate phosphatase activity
HKK55_RS22620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKK55_RS22625	COG1454	alcohol dehydrogenase
HKK55_RS22635	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK55_RS22645	COG3842	ATPase activity
HKK55_RS22650	COG2197	response regulator
HKK55_RS22670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKK55_RS22675	COG3178	'Phosphotransferase
HKK55_RS22680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HKK55_RS22685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK55_RS22690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HKK55_RS22695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKK55_RS22700	COG2967	ApaG domain
HKK55_RS22705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKK55_RS22710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK55_RS22715	COG2766	serine protein kinase
HKK55_RS22720	COG2718	Belongs to the UPF0229 family
HKK55_RS22725	COG2719	SpoVR family
HKK55_RS22730	COG0617	tRNA 3'-terminal CCA addition
HKK55_RS22740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKK55_RS22745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HKK55_RS22750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKK55_RS22755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HKK55_RS22760	COG0358	DNA primase activity
HKK55_RS22765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKK55_RS22795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKK55_RS22800	COG0154	amidase activity
HKK55_RS22810	COG0583	DNA-binding transcription factor activity
HKK55_RS22830	COG1879	ABC-type sugar transport system periplasmic component
HKK55_RS22845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK55_RS22850	COG1025	Belongs to the peptidase M16 family
HKK55_RS22860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK55_RS22865	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HKK55_RS22875	COG0535	radical SAM domain protein
HKK55_RS22895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK55_RS22900	COG0583	DNA-binding transcription factor activity
HKK55_RS22905	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS22910	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS22915	COG3706	GGDEF domain
HKK55_RS22925	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS22945	COG2226	methyltransferase
HKK55_RS22945	COG1073	alpha beta
HKK55_RS22950	COG0156	8-amino-7-oxononanoate synthase activity
HKK55_RS22955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HKK55_RS22965	COG3585	molybdate ion transport
HKK55_RS22965	COG2005	Transcriptional regulator
HKK55_RS22975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKK55_RS22985	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HKK55_RS22990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HKK55_RS23000	COG2204	response regulator
HKK55_RS23015	COG1595	DNA-templated transcription, initiation
HKK55_RS23025	COG4774	siderophore transport
HKK55_RS23045	COG4452	Inner membrane protein CreD
HKK55_RS23050	COG2205	protein histidine kinase activity
HKK55_RS23055	COG0745	RESPONSE REGULATOR receiver
HKK55_RS23060	COG4067	protein conserved in archaea
HKK55_RS23060	COG0189	ligase activity
HKK55_RS23065	COG0204	Acyl-transferase
HKK55_RS23080	COG1063	alcohol dehydrogenase
HKK55_RS23110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKK55_RS23130	COG1017	nitric oxide dioxygenase activity
HKK55_RS23130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK55_RS23135	COG4638	Rieske (2fe-2S)
HKK55_RS23150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HKK55_RS23155	COG0247	lactate metabolic process
HKK55_RS23155	COG2181	nitrate reductase activity
HKK55_RS23160	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK55_RS23160	COG1902	pentaerythritol trinitrate reductase activity
HKK55_RS23180	COG2814	Major facilitator Superfamily
HKK55_RS23210	COG3246	L-lysine catabolic process to acetate
HKK55_RS23215	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK55_RS23240	COG1760	l-serine dehydratase
HKK55_RS23250	COG4176	ABC-type proline glycine betaine transport system permease component
HKK55_RS23255	COG4175	Glycine betaine
HKK55_RS23260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKK55_RS23265	COG1309	transcriptional regulator
HKK55_RS23270	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS23275	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HKK55_RS23280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKK55_RS23300	COG0477	Major facilitator Superfamily
HKK55_RS23305	COG0513	Belongs to the DEAD box helicase family
HKK55_RS23310	COG2081	HI0933 family
HKK55_RS23315	COG1289	transmembrane transporter activity
HKK55_RS23325	COG2153	protein acetylation
HKK55_RS23335	COG1451	nucleotide metabolic process
HKK55_RS23370	COG0126	phosphoglycerate kinase activity
HKK55_RS23375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HKK55_RS23380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKK55_RS23390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKK55_RS23400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKK55_RS23435	COG0463	Glycosyl transferase, family 2
HKK55_RS23455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HKK55_RS23460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKK55_RS23470	COG0513	Belongs to the DEAD box helicase family
HKK55_RS23475	COG2353	YceI-like domain
HKK55_RS23480	COG3038	cytochrome b561
HKK55_RS23490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKK55_RS23495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS23515	COG1272	protein, Hemolysin III
HKK55_RS23545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKK55_RS23565	COG3052	prosthetic group binding
HKK55_RS23570	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HKK55_RS23595	COG0784	Response regulator, receiver
HKK55_RS23595	COG2198	Histidine kinase
HKK55_RS23595	COG0643	Histidine kinase
HKK55_RS23620	COG0189	ligase activity
HKK55_RS23630	COG1678	Uncharacterized ACR, COG1678
HKK55_RS23635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKK55_RS23640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKK55_RS23645	COG0540	Belongs to the ATCase OTCase family
HKK55_RS23650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK55_RS23660	COG0791	NLP P60 protein
HKK55_RS23685	COG1872	DUF167
HKK55_RS23690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK55_RS23695	COG2813	Specifically methylates the guanine in position
HKK55_RS23695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK55_RS23705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKK55_RS23710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKK55_RS23720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKK55_RS23725	COG2022	thiamine diphosphate biosynthetic process
HKK55_RS23735	COG2363	Small membrane protein
HKK55_RS23740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK55_RS23750	COG2177	Part of the ABC transporter FtsEX involved in
HKK55_RS23755	COG2884	Cell division ATP-binding protein ftsE
HKK55_RS23760	COG0552	protein localization to endoplasmic reticulum
HKK55_RS23765	COG0612	Peptidase, M16
HKK55_RS23770	COG0612	Peptidase, M16
HKK55_RS23775	COG0742	ribosomal rna small subunit methyltransferase
HKK55_RS23780	COG0429	hydrolase of the alpha beta-hydrolase fold
HKK55_RS23790	COG1309	transcriptional regulator
HKK55_RS23805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HKK55_RS23810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKK55_RS23815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKK55_RS23820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKK55_RS23830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK55_RS23835	COG2814	Major facilitator Superfamily
HKK55_RS23840	COG0129	dihydroxy-acid dehydratase activity
HKK55_RS23855	COG2026	Addiction module toxin, RelE StbE family
HKK55_RS23860	COG3077	Addiction module antitoxin, RelB DinJ family
HKK55_RS23875	COG1160	GTP binding
HKK55_RS23890	COG1840	ABC-type Fe3 transport system, periplasmic component
HKK55_RS23895	COG1178	ABC-type Fe3 transport system permease component
HKK55_RS23900	COG3842	ATPase activity
HKK55_RS23915	COG0789	Transcriptional regulator
HKK55_RS23920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HKK55_RS23925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKK55_RS23930	COG0730	response to heat
HKK55_RS23940	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HKK55_RS23945	COG0494	nUDIX hydrolase
HKK55_RS23960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKK55_RS23965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HKK55_RS23970	COG2234	aminopeptidase activity
HKK55_RS23975	COG3204	pilus organization
HKK55_RS23980	COG3204	pilus organization
HKK55_RS23985	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK55_RS23990	COG0277	FAD linked oxidase domain protein
HKK55_RS23995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK55_RS24005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS24010	COG1683	Conserved Protein
HKK55_RS24050	COG1177	transmembrane transport
HKK55_RS24055	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK55_RS24060	COG3842	ATPase activity
HKK55_RS24080	COG0174	glutamine synthetase
HKK55_RS24085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HKK55_RS24090	COG0174	glutamine synthetase
HKK55_RS24105	COG1116	anion transmembrane transporter activity
HKK55_RS24110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS24120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK55_RS24125	COG0431	NADPH-dependent FMN reductase
HKK55_RS24130	COG0450	alkyl hydroperoxide reductase
HKK55_RS24140	COG4521	taurine ABC transporter
HKK55_RS24145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKK55_RS24145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HKK55_RS24160	COG1522	sequence-specific DNA binding
HKK55_RS24180	COG0330	HflC and HflK could
HKK55_RS24195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HKK55_RS24200	COG0509	glycine decarboxylation via glycine cleavage system
HKK55_RS24205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK55_RS24210	COG1178	ABC-type Fe3 transport system permease component
HKK55_RS24220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK55_RS24225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK55_RS24230	COG0006	proline dipeptidase activity
HKK55_RS24235	COG3079	Belongs to the UPF0149 family
HKK55_RS24255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKK55_RS24280	COG2271	Major facilitator Superfamily
HKK55_RS24305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HKK55_RS24310	COG2755	lipolytic protein G-D-S-L family
HKK55_RS24310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HKK55_RS24325	COG2186	Transcriptional regulator
HKK55_RS24330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS24335	COG0765	amino acid transport
HKK55_RS24345	COG1126	abc transporter atp-binding protein
HKK55_RS24355	COG3188	usher protein
HKK55_RS24360	COG3121	Chaperone
HKK55_RS24370	COG0248	Ppx GppA phosphatase
HKK55_RS24375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HKK55_RS24385	COG0586	Pfam SNARE associated Golgi protein
HKK55_RS24395	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HKK55_RS24400	COG1671	Belongs to the UPF0178 family
HKK55_RS24405	COG0672	)-iron permease
HKK55_RS24410	COG1280	lysine exporter protein (LysE YggA)
HKK55_RS24420	COG0488	(ABC) transporter
HKK55_RS24445	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HKK55_RS24460	COG0181	hydroxymethylbilane synthase activity
HKK55_RS24470	COG0165	Argininosuccinate lyase
HKK55_RS24475	COG0625	glutathione transferase activity
HKK55_RS24495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK55_RS24505	COG1965	Belongs to the frataxin family
HKK55_RS24515	COG0019	diaminopimelate decarboxylase activity
HKK55_RS24520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKK55_RS24530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKK55_RS24535	COG1011	Hydrolase
HKK55_RS24545	COG0432	Pfam Uncharacterised protein family UPF0047
HKK55_RS24550	COG0004	ammonium transporteR
HKK55_RS24555	COG0347	Belongs to the P(II) protein family
HKK55_RS24570	COG0606	chelatase, subunit chli
HKK55_RS24585	COG0840	transmembrane signaling receptor activity
HKK55_RS24590	COG0583	DNA-binding transcription factor activity
HKK55_RS24595	COG0534	Mate efflux family protein
HKK55_RS24610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKK55_RS24615	COG0427	acetyl-CoA hydrolase
HKK55_RS24630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKK55_RS24640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS24655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS24665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK55_RS24670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK55_RS24680	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS24695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKK55_RS24700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HKK55_RS24705	COG0747	negative chemotaxis
HKK55_RS24710	COG2003	Belongs to the UPF0758 family
HKK55_RS24715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKK55_RS24720	COG0756	dUTP diphosphatase activity
HKK55_RS24725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK55_RS24730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKK55_RS24735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKK55_RS24740	COG0708	Exodeoxyribonuclease III
HKK55_RS24750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HKK55_RS24755	COG1561	YicC-like family, N-terminal region
HKK55_RS24760	COG0194	GDP metabolic process
HKK55_RS24765	COG1758	RNA polymerase activity
HKK55_RS24770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKK55_RS24800	COG0848	biopolymer transport protein
HKK55_RS24810	COG0583	DNA-binding transcription factor activity
HKK55_RS24815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKK55_RS24845	COG0577	efflux transmembrane transporter activity
HKK55_RS24845	COG1136	(ABC) transporter
HKK55_RS24850	COG2815	serine threonine protein kinase
HKK55_RS24850	COG0515	serine threonine protein kinase
HKK55_RS24855	COG0631	protein serine/threonine phosphatase activity
HKK55_RS24930	COG3501	Rhs element vgr protein
HKK55_RS24935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKK55_RS24980	COG3161	chorismate lyase activity
HKK55_RS24985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HKK55_RS25005	COG1253	flavin adenine dinucleotide binding
HKK55_RS25010	COG0739	heme binding
HKK55_RS25030	COG0704	Plays a role in the regulation of phosphate uptake
HKK55_RS25035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK55_RS25040	COG0573	inorganic phosphate transmembrane transporter activity
HKK55_RS25055	COG0477	Major facilitator Superfamily
HKK55_RS25060	COG1607	acyl-coa hydrolase
HKK55_RS25090	COG0583	DNA-binding transcription factor activity
HKK55_RS25095	COG1027	Aspartate ammonia-lyase
HKK55_RS25100	COG1115	amino acid carrier protein
HKK55_RS25105	COG0252	asparaginase activity
HKK55_RS25170	COG5016	pyruvate
HKK55_RS25170	COG0511	ligase activity, forming carbon-carbon bonds
HKK55_RS25175	COG0439	Biotin carboxylase
HKK55_RS25180	COG0583	DNA-binding transcription factor activity
HKK55_RS25200	COG0210	DNA helicase
HKK55_RS25215	COG4651	solute:proton antiporter activity
HKK55_RS25215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKK55_RS25220	COG1607	acyl-coa hydrolase
HKK55_RS25225	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HKK55_RS25235	COG0523	cobalamin synthesis protein
HKK55_RS25260	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKK55_RS25265	COG1469	GTP cyclohydrolase I activity
HKK55_RS25270	COG1121	(ABC) transporter
HKK55_RS25285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKK55_RS25295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK55_RS25305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK55_RS25315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HKK55_RS25355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKK55_RS25360	COG2267	carboxylic ester hydrolase activity
HKK55_RS25365	COG0671	phosphoesterase, PA-phosphatase related
HKK55_RS25365	COG2453	phosphatase
HKK55_RS25380	COG4589	Belongs to the CDS family
HKK55_RS25395	COG2373	Large extracellular alpha-helical protein
HKK55_RS25400	COG4953	penicillin-binding protein 1C
HKK55_RS25410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKK55_RS25415	COG1349	DNA-binding transcription factor activity
HKK55_RS25420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK55_RS25425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HKK55_RS25430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKK55_RS25435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKK55_RS25440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKK55_RS25445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKK55_RS25450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HKK55_RS25460	COG0356	it plays a direct role in the translocation of protons across the membrane
HKK55_RS25465	COG3312	ion transport
HKK55_RS25470	COG1475	DNA binding
HKK55_RS25475	COG1192	Involved in chromosome partitioning
HKK55_RS25480	COG0357	Ribosomal RNA small subunit methyltransferase G
HKK55_RS25485	COG0445	tRNA wobble uridine modification
HKK55_RS25490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HKK55_RS25495	COG0706	membrane insertase activity
HKK55_RS25500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HKK55_RS25505	COG0594	ribonuclease P activity
HKK55_RS25510	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HKK55_RS25515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKK55_RS25520	COG0592	DNA-directed DNA polymerase activity
HKK55_RS25525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKK55_RS25530	COG0187	DNA topoisomerase II activity
HKK55_RS25535	COG0745	RESPONSE REGULATOR receiver
HKK55_RS25545	COG5002	protein histidine kinase activity
HKK55_RS25560	COG0751	glycine-tRNA ligase activity
HKK55_RS25565	COG0752	glycyl-tRNA synthetase alpha subunit
HKK55_RS25570	COG2818	Glycosylase
HKK55_RS25585	COG0569	domain protein
HKK55_RS25590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKK55_RS25595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK55_RS25600	COG0242	peptide deformylase activity
HKK55_RS25610	COG0758	DNA mediated transformation
HKK55_RS25615	COG0009	L-threonylcarbamoyladenylate synthase
HKK55_RS25625	COG0408	coproporphyrinogen oxidase activity
HKK55_RS25630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK55_RS25645	COG3119	arylsulfatase activity
HKK55_RS25650	COG0583	DNA-binding transcription factor activity
HKK55_RS25660	COG3734	2-keto-3-deoxy-galactonokinase
HKK55_RS25665	COG0800	Aldolase
HKK55_RS25670	COG4948	Mandelate Racemase Muconate Lactonizing
HKK55_RS25675	COG2271	Major facilitator Superfamily
HKK55_RS25690	COG0159	tryptophan synthase activity
HKK55_RS25710	COG3360	Dodecin
HKK55_RS25720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK55_RS25725	COG1764	response to oxidative stress
HKK55_RS25755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKK55_RS25760	COG0339	signal peptide processing
HKK55_RS25765	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HKK55_RS25770	COG0339	signal peptide processing
HKK55_RS25805	COG0659	secondary active sulfate transmembrane transporter activity
HKK55_RS25815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKK55_RS25820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKK55_RS25825	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HKK55_RS25855	COG0109	protoheme IX farnesyltransferase activity
HKK55_RS25870	COG2011	ABC-type metal ion transport system permease component
HKK55_RS25875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK55_RS25890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK55_RS25895	COG1121	(ABC) transporter
HKK55_RS25900	COG0735	belongs to the Fur family
HKK55_RS25905	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HKK55_RS25925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HKK55_RS25930	COG3245	cytochrome
HKK55_RS25940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKK55_RS25955	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKK55_RS25960	COG5002	protein histidine kinase activity
HKK55_RS25965	COG2204	response regulator
HKK55_RS25975	COG5487	UPF0391 membrane protein
HKK55_RS25985	COG1301	dicarboxylic acid transport
HKK55_RS25990	COG0700	Nucleoside recognition
HKK55_RS26005	COG1127	ABC transporter
HKK55_RS26010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKK55_RS26020	COG0612	Peptidase, M16
HKK55_RS26025	COG1283	sodium-dependent phosphate transmembrane transporter activity
HKK55_RS26030	COG0861	Integral membrane protein TerC family
HKK55_RS26035	COG2851	Citrate transporter
HKK55_RS26075	COG0427	acetyl-CoA hydrolase
HKK55_RS26095	COG0583	DNA-binding transcription factor activity
HKK55_RS26100	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS26155	COG0840	transmembrane signaling receptor activity
HKK55_RS26165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKK55_RS26180	COG1802	Transcriptional regulator
HKK55_RS26190	COG3300	MHYT domain
HKK55_RS26190	COG5001	Diguanylate cyclase
HKK55_RS26205	COG1538	Outer membrane efflux protein
HKK55_RS26210	COG2274	protein secretion by the type I secretion system
HKK55_RS26215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK55_RS26220	COG2175	clavaminate synthase activity
HKK55_RS26235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS26285	COG1289	transmembrane transporter activity
HKK55_RS26295	COG1566	PFAM secretion protein HlyD family protein
HKK55_RS26310	COG5339	Protein conserved in bacteria
HKK55_RS26315	COG0457	Tetratricopeptide repeat
HKK55_RS26320	COG1649	PFAM Uncharacterised BCR, COG1649
HKK55_RS26320	COG0726	polysaccharide deacetylase
HKK55_RS26325	COG1215	transferase activity, transferring glycosyl groups
HKK55_RS26420	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK55_RS26425	COG2304	oxidoreductase activity
HKK55_RS26485	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS26490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK55_RS26500	COG0745	RESPONSE REGULATOR receiver
HKK55_RS26505	COG0745	RESPONSE REGULATOR receiver
HKK55_RS26510	COG2205	protein histidine kinase activity
HKK55_RS26550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKK55_RS26560	COG4208	sulfate ABC transporter
HKK55_RS26565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HKK55_RS26615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS26620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK55_RS26645	COG4771	TonB-dependent receptor
HKK55_RS26650	COG2807	transmembrane transport
HKK55_RS26655	COG0590	tRNA wobble adenosine to inosine editing
HKK55_RS26660	COG0583	DNA-binding transcription factor activity
HKK55_RS26700	COG0765	amino acid transport
HKK55_RS26705	COG0765	amino acid transport
HKK55_RS26710	COG1126	abc transporter atp-binding protein
HKK55_RS26715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS26720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKK55_RS26750	COG2011	ABC-type metal ion transport system permease component
HKK55_RS26755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK55_RS26760	COG1464	Belongs to the NlpA lipoprotein family
HKK55_RS26805	COG1045	serine acetyltransferase
HKK55_RS26810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKK55_RS26820	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS26835	COG0667	Aldo Keto reductase
HKK55_RS26840	COG2175	clavaminate synthase activity
HKK55_RS26845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK55_RS26850	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HKK55_RS26855	COG4521	taurine ABC transporter
HKK55_RS26860	COG2918	glutathione biosynthetic process
HKK55_RS26870	COG2183	response to ionizing radiation
HKK55_RS26875	COG0745	RESPONSE REGULATOR receiver
HKK55_RS26885	COG0189	ligase activity
HKK55_RS26890	COG4067	protein conserved in archaea
HKK55_RS26890	COG0189	ligase activity
HKK55_RS26895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKK55_RS26900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HKK55_RS26905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HKK55_RS26920	COG0514	ATP-dependent DNA helicase (RecQ)
HKK55_RS26925	COG0824	Thioesterase
HKK55_RS26935	COG0243	molybdopterin cofactor binding
HKK55_RS26940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HKK55_RS26945	COG1652	LysM domain
HKK55_RS26950	COG1011	Hydrolase
HKK55_RS26955	COG0494	nUDIX hydrolase
HKK55_RS26960	COG1218	3'(2'),5'-bisphosphate nucleotidase
HKK55_RS27000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK55_RS27010	COG2957	Belongs to the agmatine deiminase family
HKK55_RS27040	COG1942	4-Oxalocrotonate Tautomerase
HKK55_RS27045	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS27120	COG3041	Addiction module toxin RelE StbE family
HKK55_RS27135	COG2197	response regulator
HKK55_RS27205	COG1538	Outer membrane efflux protein
HKK55_RS27210	COG2274	protein secretion by the type I secretion system
HKK55_RS27230	COG0582	viral genome integration into host DNA
HKK55_RS27355	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HKK55_RS27360	COG1194	a g-specific adenine glycosylase
HKK55_RS27370	COG2223	nitrite transmembrane transporter activity
HKK55_RS27375	COG0131	Imidazoleglycerol-phosphate dehydratase
HKK55_RS27380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKK55_RS27390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKK55_RS27395	COG0107	imidazoleglycerol-phosphate synthase activity
HKK55_RS27410	COG2861	carbohydrate metabolic process
HKK55_RS27415	COG0793	Belongs to the peptidase S41A family
HKK55_RS27420	COG4942	peptidase
HKK55_RS27425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKK55_RS27430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK55_RS27440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HKK55_RS27445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HKK55_RS27460	COG3852	Histidine kinase
HKK55_RS27475	COG0301	tRNA thio-modification
HKK55_RS27475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK55_RS27490	COG0058	SHG alpha-glucan phosphorylase activity
HKK55_RS27505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HKK55_RS27515	COG3040	lipid binding
HKK55_RS27520	COG0402	S-adenosylhomocysteine deaminase activity
HKK55_RS27525	COG2188	Transcriptional regulator
HKK55_RS27535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HKK55_RS27540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKK55_RS27550	COG4176	ABC-type proline glycine betaine transport system permease component
HKK55_RS27555	COG4175	Glycine betaine
HKK55_RS27555	COG0517	IMP dehydrogenase activity
HKK55_RS27560	COG2986	histidine ammonia-lyase
HKK55_RS27565	COG2986	histidine ammonia-lyase
HKK55_RS27575	COG1228	amidohydrolase
HKK55_RS27595	COG0596	Alpha beta hydrolase
HKK55_RS27600	COG1490	D-aminoacyl-tRNA deacylase activity
HKK55_RS27605	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HKK55_RS27610	COG2943	transferase activity, transferring hexosyl groups
HKK55_RS27615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS27620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK55_RS27625	COG0765	amino acid transport
HKK55_RS27630	COG1126	abc transporter atp-binding protein
HKK55_RS27635	COG0840	transmembrane signaling receptor activity
HKK55_RS27640	COG0840	transmembrane signaling receptor activity
HKK55_RS27655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKK55_RS27660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKK55_RS27665	COG0140	phosphoribosyl-ATP diphosphatase activity
HKK55_RS27670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKK55_RS27675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKK55_RS27685	COG2226	methyltransferase
HKK55_RS27730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HKK55_RS27735	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HKK55_RS27745	COG0018	arginyl-trna synthetase
HKK55_RS27750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKK55_RS27755	COG0254	rRNA binding
HKK55_RS27765	COG0281	malic enzyme
HKK55_RS27800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKK55_RS27805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKK55_RS27815	COG0070	glutamate synthase
HKK55_RS27815	COG0069	glutamate synthase activity
HKK55_RS27815	COG0067	glutamate synthase
HKK55_RS27820	COG0493	'glutamate synthase
HKK55_RS27825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HKK55_RS27830	COG2814	Major facilitator Superfamily
HKK55_RS27835	COG0583	DNA-binding transcription factor activity
HKK55_RS27850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK55_RS27855	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS27865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK55_RS27875	COG2226	methyltransferase
HKK55_RS27900	COG2986	histidine ammonia-lyase
HKK55_RS27925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK55_RS27930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK55_RS27945	COG1192	Involved in chromosome partitioning
HKK55_RS27955	COG3118	belongs to the thioredoxin family
HKK55_RS27965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HKK55_RS27970	COG3264	Mechanosensitive ion channel
HKK55_RS27970	COG1196	nuclear chromosome segregation
HKK55_RS27975	COG3263	regulation of cellular component size
HKK55_RS27995	COG1960	acyl-CoA dehydrogenase activity
HKK55_RS28000	COG0506	proline dehydrogenase activity
HKK55_RS28000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKK55_RS28000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKK55_RS28005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK55_RS28015	COG3501	Rhs element vgr protein
HKK55_RS28025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HKK55_RS28030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK55_RS28050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKK55_RS28055	COG0859	PFAM glycosyl transferase family 9
HKK55_RS28060	COG0859	PFAM glycosyl transferase family 9
HKK55_RS28065	COG0438	transferase activity, transferring glycosyl groups
HKK55_RS28075	COG3642	lipopolysaccharide core region biosynthetic process
HKK55_RS28095	COG4772	TonB-dependent receptor
HKK55_RS28105	COG2192	nodulation
HKK55_RS28110	COG0438	transferase activity, transferring glycosyl groups
HKK55_RS28130	COG1215	transferase activity, transferring glycosyl groups
HKK55_RS28140	COG1132	(ABC) transporter
HKK55_RS28155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HKK55_RS28155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HKK55_RS28170	COG0667	Aldo Keto reductase
HKK55_RS28190	COG1519	Transferase
HKK55_RS28195	COG1538	Outer membrane efflux protein
HKK55_RS28200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HKK55_RS28215	COG0494	nUDIX hydrolase
HKK55_RS28225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKK55_RS28240	COG0583	DNA-binding transcription factor activity
HKK55_RS28245	COG3150	esterase
HKK55_RS28285	COG0688	phosphatidylethanolamine metabolic process
HKK55_RS28310	COG1162	GTPase activity
HKK55_RS28315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HKK55_RS28320	COG2860	membrane
HKK55_RS28330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKK55_RS28330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKK55_RS28335	COG0802	atpase or kinase
HKK55_RS28340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKK55_RS28345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKK55_RS28350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKK55_RS28355	COG1923	regulation of RNA biosynthetic process
HKK55_RS28360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKK55_RS28365	COG0330	HflC and HflK could
HKK55_RS28370	COG0330	HflC and HflK could
HKK55_RS28375	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HKK55_RS28380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKK55_RS28390	COG1178	ABC-type Fe3 transport system permease component
HKK55_RS28395	COG1840	ABC-type Fe3 transport system, periplasmic component
HKK55_RS28410	COG0557	exoribonuclease II activity
HKK55_RS28415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKK55_RS28420	COG0360	Binds together with S18 to 16S ribosomal RNA
HKK55_RS28425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKK55_RS28435	COG0359	binds to the 23S rRNA
HKK55_RS28440	COG0305	Participates in initiation and elongation during chromosome replication
HKK55_RS28450	COG1032	radical SAM domain protein
HKK55_RS28480	COG2308	Evidence 4 Homologs of previously reported genes of
HKK55_RS28480	COG2307	Protein conserved in bacteria
HKK55_RS28505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKK55_RS28510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKK55_RS28515	COG0583	DNA-binding transcription factor activity
HKK55_RS28520	COG1012	belongs to the aldehyde dehydrogenase family
HKK55_RS28525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK55_RS28555	COG4221	oxidoreductase activity
HKK55_RS28575	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKK55_RS28580	COG0830	nickel cation binding
HKK55_RS28585	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HKK55_RS28590	COG0791	NLP P60 protein
HKK55_RS28595	COG1309	transcriptional regulator
HKK55_RS28605	COG2982	Protein involved in outer membrane biogenesis
HKK55_RS28615	COG0583	DNA-binding transcription factor activity
HKK55_RS28620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK55_RS28630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HKK55_RS28635	COG0697	spore germination
HKK55_RS28655	COG0443	Heat shock 70 kDa protein
HKK55_RS28660	COG0484	heat shock protein binding
HKK55_RS28665	COG0789	Transcriptional regulator
HKK55_RS28675	COG0804	urea catabolic process
HKK55_RS28680	COG0832	Belongs to the urease beta subunit family
HKK55_RS28695	COG0831	urea catabolic process
HKK55_RS28700	COG0829	nickel cation binding
HKK55_RS28710	COG0411	ABC transporter
HKK55_RS28725	COG0683	leucine binding
HKK55_RS28730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK55_RS28740	COG1120	ATPase activity
HKK55_RS28805	COG2095	MarC family integral membrane protein
HKK55_RS28815	COG0151	Belongs to the GarS family
HKK55_RS28820	COG0138	bifunctional purine biosynthesis protein purh
HKK55_RS28830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKK55_RS28840	COG2264	protein methyltransferase activity
HKK55_RS28855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HKK55_RS28880	COG0023	Translation Initiation Factor
HKK55_RS28885	COG1166	arginine decarboxylase activity
HKK55_RS28900	COG0534	Mate efflux family protein
HKK55_RS28920	COG0583	DNA-binding transcription factor activity
HKK55_RS28925	COG2373	Large extracellular alpha-helical protein
HKK55_RS28935	COG4953	penicillin-binding protein 1C
HKK55_RS28945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKK55_RS29015	COG4964	Belongs to the GSP D family
HKK55_RS29030	COG0745	RESPONSE REGULATOR receiver
HKK55_RS29050	COG1028	Short-chain dehydrogenase reductase Sdr
HKK55_RS29080	COG2814	Major facilitator Superfamily
HKK55_RS29090	COG0604	alcohol dehydrogenase
HKK55_RS29095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HKK55_RS29100	COG0583	DNA-binding transcription factor activity
HKK55_RS29110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKK55_RS29115	COG0387	Pfam Sodium calcium exchanger
HKK55_RS29130	COG1739	Uncharacterized protein family UPF0029
HKK55_RS29135	COG1309	transcriptional regulator
HKK55_RS29140	COG2233	PERMEase