locus-tag	class	description
HKK58_RS00030	COG0583	DNA-binding transcription factor activity
HKK58_RS00040	COG0768	penicillin binding
HKK58_RS00065	COG0417	DNA replication proofreading
HKK58_RS00090	COG0728	peptidoglycan biosynthetic process
HKK58_RS00135	COG0662	Cupin 2, conserved barrel domain protein
HKK58_RS00135	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HKK58_RS00150	COG3712	iron ion homeostasis
HKK58_RS00155	COG1595	DNA-templated transcription, initiation
HKK58_RS00170	COG4977	sequence-specific DNA binding
HKK58_RS00175	COG4251	negative regulation of phosphorylation
HKK58_RS00185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKK58_RS00195	COG3387	PFAM Glycoside hydrolase 15-related
HKK58_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS00205	COG2207	Transcriptional regulator
HKK58_RS00225	COG1595	DNA-templated transcription, initiation
HKK58_RS00235	COG4772	TonB-dependent receptor
HKK58_RS00255	COG2223	nitrite transmembrane transporter activity
HKK58_RS00265	COG3501	Rhs element vgr protein
HKK58_RS00285	COG0402	S-adenosylhomocysteine deaminase activity
HKK58_RS00295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKK58_RS00315	COG0720	synthase
HKK58_RS00335	COG0745	RESPONSE REGULATOR receiver
HKK58_RS00340	COG2205	protein histidine kinase activity
HKK58_RS00345	COG0840	transmembrane signaling receptor activity
HKK58_RS00350	COG2056	Na+-H+ antiporter family
HKK58_RS00365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKK58_RS00370	COG0436	Aminotransferase
HKK58_RS00405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK58_RS00410	COG3132	Protein of unknown function, DUF480
HKK58_RS00420	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HKK58_RS00430	COG0583	DNA-binding transcription factor activity
HKK58_RS00440	COG1253	flavin adenine dinucleotide binding
HKK58_RS00445	COG0709	Synthesizes selenophosphate from selenide and ATP
HKK58_RS00450	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HKK58_RS00455	COG0701	Predicted permease
HKK58_RS00465	COG0625	glutathione transferase activity
HKK58_RS00470	COG0384	phenazine biosynthesis protein PhzF
HKK58_RS00475	COG0113	porphobilinogen synthase activity
HKK58_RS00485	COG3209	COG3209 Rhs family protein
HKK58_RS00490	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS00520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKK58_RS00525	COG0583	DNA-binding transcription factor activity
HKK58_RS00535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKK58_RS00540	COG0517	IMP dehydrogenase activity
HKK58_RS00545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKK58_RS00570	COG4335	DNA alkylation repair
HKK58_RS00575	COG0174	glutamine synthetase
HKK58_RS00595	COG2814	Major facilitator Superfamily
HKK58_RS00605	COG3237	CsbD-like
HKK58_RS00620	COG4977	sequence-specific DNA binding
HKK58_RS00620	COG1917	Cupin 2, conserved barrel domain protein
HKK58_RS00625	COG0384	phenazine biosynthesis protein PhzF
HKK58_RS00655	COG2197	response regulator
HKK58_RS00660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS00660	COG2205	protein histidine kinase activity
HKK58_RS00670	COG0656	L-ascorbic acid biosynthetic process
HKK58_RS00685	COG0515	serine threonine protein kinase
HKK58_RS00715	COG1902	pentaerythritol trinitrate reductase activity
HKK58_RS00715	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK58_RS00720	COG0235	Class ii aldolase
HKK58_RS00730	COG1024	Enoyl-CoA hydratase
HKK58_RS00735	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS00770	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK58_RS00775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKK58_RS00780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK58_RS00800	COG2197	response regulator
HKK58_RS00805	COG0322	excinuclease ABC activity
HKK58_RS00865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK58_RS00885	COG1063	alcohol dehydrogenase
HKK58_RS00930	COG0300	oxidoreductase activity
HKK58_RS00965	COG2831	hemolysin activation secretion protein
HKK58_RS00970	COG3210	domain, Protein
HKK58_RS01130	COG1595	DNA-templated transcription, initiation
HKK58_RS01140	COG3284	Transcriptional regulator
HKK58_RS01145	COG3842	ATPase activity
HKK58_RS01150	COG3842	ATPase activity
HKK58_RS01160	COG0395	ABC-type sugar transport system, permease component
HKK58_RS01175	COG2207	Transcriptional regulator
HKK58_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS01200	COG1063	alcohol dehydrogenase
HKK58_RS01240	COG2814	Major facilitator Superfamily
HKK58_RS01260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKK58_RS01270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS01275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS01295	COG0667	Aldo Keto reductase
HKK58_RS01330	COG1741	Belongs to the pirin family
HKK58_RS01350	COG4977	sequence-specific DNA binding
HKK58_RS01350	COG1917	Cupin 2, conserved barrel domain protein
HKK58_RS01365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HKK58_RS01370	COG1335	isochorismatase
HKK58_RS01375	COG0583	DNA-binding transcription factor activity
HKK58_RS01390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK58_RS01395	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS01405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS01410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS01415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK58_RS01425	COG0583	DNA-binding transcription factor activity
HKK58_RS01445	COG2205	protein histidine kinase activity
HKK58_RS01450	COG0745	RESPONSE REGULATOR receiver
HKK58_RS01465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK58_RS01470	COG2011	ABC-type metal ion transport system permease component
HKK58_RS01490	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS01495	COG3706	GGDEF domain
HKK58_RS01505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK58_RS01510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS01515	COG2814	Major facilitator Superfamily
HKK58_RS01530	COG1959	2 iron, 2 sulfur cluster binding
HKK58_RS01570	COG2207	Transcriptional regulator
HKK58_RS01610	COG2814	Major facilitator Superfamily
HKK58_RS01635	COG0745	RESPONSE REGULATOR receiver
HKK58_RS01640	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HKK58_RS01645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKK58_RS01650	COG0583	DNA-binding transcription factor activity
HKK58_RS01665	COG2271	Major facilitator Superfamily
HKK58_RS01670	COG1609	Transcriptional regulator
HKK58_RS01690	COG2072	flavoprotein involved in K transport
HKK58_RS01730	COG0583	DNA-binding transcription factor activity
HKK58_RS01740	COG0165	Argininosuccinate lyase
HKK58_RS01750	COG1999	signal sequence binding
HKK58_RS01790	COG0693	protein deglycase activity
HKK58_RS01815	COG1349	DNA-binding transcription factor activity
HKK58_RS01820	COG1304	FMN binding
HKK58_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS01835	COG0494	nUDIX hydrolase
HKK58_RS01855	COG0616	signal peptide processing
HKK58_RS01865	COG0583	DNA-binding transcription factor activity
HKK58_RS01875	COG1253	flavin adenine dinucleotide binding
HKK58_RS01880	COG3118	belongs to the thioredoxin family
HKK58_RS01895	COG0765	amino acid transport
HKK58_RS01900	COG0765	amino acid transport
HKK58_RS01925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK58_RS01945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK58_RS01955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK58_RS01960	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS01965	COG2610	gluconate transmembrane transporter activity
HKK58_RS01970	COG3829	transcription factor binding
HKK58_RS01970	COG3290	protein histidine kinase activity
HKK58_RS01975	COG4172	Belongs to the ABC transporter superfamily
HKK58_RS01980	COG4239	(ABC) transporter, permease
HKK58_RS01985	COG4174	ABC transporter (Permease)
HKK58_RS01990	COG4166	transmembrane transport
HKK58_RS01995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK58_RS02000	COG4172	Belongs to the ABC transporter superfamily
HKK58_RS02005	COG4239	(ABC) transporter, permease
HKK58_RS02010	COG4174	ABC transporter (Permease)
HKK58_RS02015	COG4166	transmembrane transport
HKK58_RS02020	COG4166	transmembrane transport
HKK58_RS02025	COG0741	lytic transglycosylase activity
HKK58_RS02025	COG1388	LysM domain
HKK58_RS02030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKK58_RS02040	COG0328	RNA-DNA hybrid ribonuclease activity
HKK58_RS02045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK58_RS02050	COG1982	Orn Lys Arg decarboxylase major
HKK58_RS02055	COG0456	acetyltransferase
HKK58_RS02080	COG0431	NADPH-dependent FMN reductase
HKK58_RS02085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK58_RS02090	COG0583	DNA-binding transcription factor activity
HKK58_RS02095	COG0028	Belongs to the TPP enzyme family
HKK58_RS02135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HKK58_RS02140	COG0316	Belongs to the HesB IscA family
HKK58_RS02140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HKK58_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS02200	COG1136	(ABC) transporter
HKK58_RS02200	COG0577	efflux transmembrane transporter activity
HKK58_RS02215	COG1522	sequence-specific DNA binding
HKK58_RS02220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK58_RS02230	COG2814	Major facilitator Superfamily
HKK58_RS02245	COG0174	glutamine synthetase
HKK58_RS02255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS02260	COG0583	DNA-binding transcription factor activity
HKK58_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS02280	COG2205	protein histidine kinase activity
HKK58_RS02285	COG0745	RESPONSE REGULATOR receiver
HKK58_RS02315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS02320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK58_RS02335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK58_RS02345	COG3718	enzyme involved in inositol metabolism
HKK58_RS02355	COG3962	Belongs to the TPP enzyme family
HKK58_RS02360	COG0673	inositol 2-dehydrogenase activity
HKK58_RS02365	COG1082	Xylose isomerase domain protein TIM barrel
HKK58_RS02370	COG0673	inositol 2-dehydrogenase activity
HKK58_RS02385	COG1129	ABC transporter
HKK58_RS02390	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK58_RS02435	COG4774	siderophore transport
HKK58_RS02465	COG3209	COG3209 Rhs family protein
HKK58_RS02470	COG4774	siderophore transport
HKK58_RS02480	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK58_RS02500	COG2203	Gaf domain
HKK58_RS02500	COG3706	GGDEF domain
HKK58_RS02500	COG5001	Diguanylate cyclase
HKK58_RS02500	COG4251	negative regulation of phosphorylation
HKK58_RS02545	COG0673	inositol 2-dehydrogenase activity
HKK58_RS02555	COG2207	Transcriptional regulator
HKK58_RS02570	COG2066	Belongs to the glutaminase family
HKK58_RS02575	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKK58_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS02600	COG0019	diaminopimelate decarboxylase activity
HKK58_RS02605	COG1609	Transcriptional regulator
HKK58_RS02615	COG1175	transmembrane transport
HKK58_RS02625	COG3842	ATPase activity
HKK58_RS02630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKK58_RS02675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HKK58_RS02680	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HKK58_RS02690	COG0596	Alpha beta hydrolase
HKK58_RS02695	COG0625	glutathione transferase activity
HKK58_RS02725	COG2989	Protein conserved in bacteria
HKK58_RS02740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKK58_RS02760	COG0656	L-ascorbic acid biosynthetic process
HKK58_RS02805	COG2204	response regulator
HKK58_RS02865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKK58_RS02885	COG2267	carboxylic ester hydrolase activity
HKK58_RS02890	COG3239	Fatty acid desaturase
HKK58_RS02920	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS02940	COG0318	PFAM AMP-dependent synthetase and ligase
HKK58_RS02955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK58_RS02965	COG1609	Transcriptional regulator
HKK58_RS02980	COG3468	outer membrane autotransporter barrel domain protein
HKK58_RS02995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS03000	COG0745	RESPONSE REGULATOR receiver
HKK58_RS03005	COG2205	protein histidine kinase activity
HKK58_RS03015	COG1595	DNA-templated transcription, initiation
HKK58_RS03030	COG0730	response to heat
HKK58_RS03040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS03050	COG0189	ligase activity
HKK58_RS03055	COG0598	Magnesium transport protein CorA
HKK58_RS03060	COG0024	Methionine aminopeptidase
HKK58_RS03070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKK58_RS03090	COG1070	Carbohydrate kinase
HKK58_RS03110	COG1175	transmembrane transport
HKK58_RS03150	COG1538	Outer membrane efflux protein
HKK58_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS03175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS03180	COG0348	domain, Protein
HKK58_RS03190	COG1285	pathogenesis
HKK58_RS03215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKK58_RS03225	COG0784	Response regulator, receiver
HKK58_RS03225	COG4191	Histidine kinase
HKK58_RS03265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKK58_RS03270	COG3397	chitin binding
HKK58_RS03275	COG3318	Belongs to the UPF0149 family
HKK58_RS03275	COG3012	SEC-C Motif Domain Protein
HKK58_RS03280	COG0038	chloride channel
HKK58_RS03285	COG1024	Enoyl-CoA hydratase
HKK58_RS03290	COG2816	NAD+ diphosphatase activity
HKK58_RS03320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK58_RS03350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK58_RS03355	COG1595	DNA-templated transcription, initiation
HKK58_RS03360	COG3712	iron ion homeostasis
HKK58_RS03365	COG1116	anion transmembrane transporter activity
HKK58_RS03370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK58_RS03375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS03390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKK58_RS03395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK58_RS03405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK58_RS03415	COG0583	DNA-binding transcription factor activity
HKK58_RS03430	COG0277	FAD linked oxidase domain protein
HKK58_RS03435	COG0436	Aminotransferase
HKK58_RS03440	COG0765	amino acid transport
HKK58_RS03450	COG1126	abc transporter atp-binding protein
HKK58_RS03460	COG0625	glutathione transferase activity
HKK58_RS03475	COG2271	Major facilitator Superfamily
HKK58_RS03480	COG1335	isochorismatase
HKK58_RS03485	COG3473	Maleate cis-trans isomerase
HKK58_RS03490	COG0596	Alpha beta hydrolase
HKK58_RS03495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK58_RS03500	COG2309	aminopeptidase activity
HKK58_RS03505	COG1846	Transcriptional regulator
HKK58_RS03510	COG2080	2 iron, 2 sulfur cluster binding
HKK58_RS03515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK58_RS03515	COG2010	Cytochrome c
HKK58_RS03520	COG1309	transcriptional regulator
HKK58_RS03535	COG1846	Transcriptional regulator
HKK58_RS03540	COG0708	Exodeoxyribonuclease III
HKK58_RS03545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK58_RS03560	COG0840	transmembrane signaling receptor activity
HKK58_RS03565	COG1968	undecaprenyl-diphosphatase activity
HKK58_RS03580	COG0583	DNA-binding transcription factor activity
HKK58_RS03590	COG2207	Transcriptional regulator
HKK58_RS03595	COG2814	Major facilitator Superfamily
HKK58_RS03600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK58_RS03615	COG0488	(ABC) transporter
HKK58_RS03625	COG0500	methyltransferase
HKK58_RS03650	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HKK58_RS03660	COG2133	pyrroloquinoline quinone binding
HKK58_RS03675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK58_RS03685	COG2822	iron ion transport
HKK58_RS03695	COG2822	iron ion transport
HKK58_RS03700	COG0672	)-iron permease
HKK58_RS03705	COG2207	Transcriptional regulator
HKK58_RS03710	COG0076	glutamate decarboxylase activity
HKK58_RS03735	COG1538	Outer membrane efflux protein
HKK58_RS03740	COG2814	Major facilitator Superfamily
HKK58_RS03760	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS03805	COG2814	Major facilitator Superfamily
HKK58_RS03815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK58_RS03815	COG1024	Enoyl-CoA hydratase
HKK58_RS03830	COG0529	Catalyzes the synthesis of activated sulfate
HKK58_RS03835	COG1064	alcohol dehydrogenase
HKK58_RS03850	COG0583	DNA-binding transcription factor activity
HKK58_RS03860	COG4948	Mandelate Racemase Muconate Lactonizing
HKK58_RS03865	COG2084	Dehydrogenase
HKK58_RS03885	COG0604	alcohol dehydrogenase
HKK58_RS03885	COG3321	synthase
HKK58_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS03895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS03910	COG0210	DNA helicase
HKK58_RS03925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS03985	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK58_RS04010	COG0513	Belongs to the DEAD box helicase family
HKK58_RS04015	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS04025	COG2267	carboxylic ester hydrolase activity
HKK58_RS04035	COG0745	RESPONSE REGULATOR receiver
HKK58_RS04040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK58_RS04050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK58_RS04065	COG2308	Evidence 4 Homologs of previously reported genes of
HKK58_RS04090	COG0583	DNA-binding transcription factor activity
HKK58_RS04095	COG0667	Aldo Keto reductase
HKK58_RS04130	COG0697	spore germination
HKK58_RS04145	COG0583	DNA-binding transcription factor activity
HKK58_RS04150	COG1716	ATPase activity
HKK58_RS04150	COG5001	Diguanylate cyclase
HKK58_RS04155	COG0784	Response regulator, receiver
HKK58_RS04160	COG2205	protein histidine kinase activity
HKK58_RS04160	COG2202	Pas domain
HKK58_RS04175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK58_RS04180	COG1879	ABC-type sugar transport system periplasmic component
HKK58_RS04185	COG1609	Transcriptional regulator
HKK58_RS04190	COG1070	Carbohydrate kinase
HKK58_RS04200	COG0656	L-ascorbic acid biosynthetic process
HKK58_RS04220	COG0826	peptidase U32
HKK58_RS04230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK58_RS04250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HKK58_RS04260	COG0583	DNA-binding transcription factor activity
HKK58_RS04265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK58_RS04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS04295	COG1942	4-Oxalocrotonate Tautomerase
HKK58_RS04305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HKK58_RS04305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HKK58_RS04325	COG0295	cytidine deaminase activity
HKK58_RS04330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HKK58_RS04345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKK58_RS04395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK58_RS04405	COG2010	Cytochrome c
HKK58_RS04410	COG3608	succinylglutamate desuccinylase aspartoacylase
HKK58_RS04410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKK58_RS04415	COG0784	Response regulator, receiver
HKK58_RS04415	COG4191	Histidine kinase
HKK58_RS04420	COG3237	CsbD-like
HKK58_RS04425	COG0586	Pfam SNARE associated Golgi protein
HKK58_RS04435	COG0302	gtp cyclohydrolase
HKK58_RS04470	COG1802	Transcriptional regulator
HKK58_RS04475	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS04490	COG0765	amino acid transport
HKK58_RS04500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK58_RS04510	COG1942	4-Oxalocrotonate Tautomerase
HKK58_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS04535	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HKK58_RS04540	COG1349	DNA-binding transcription factor activity
HKK58_RS04550	COG0738	Major facilitator superfamily
HKK58_RS04560	COG2814	Major facilitator Superfamily
HKK58_RS04570	COG0583	DNA-binding transcription factor activity
HKK58_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS04580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKK58_RS04590	COG0463	Glycosyl transferase, family 2
HKK58_RS04595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK58_RS04595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK58_RS04600	COG0726	polysaccharide deacetylase
HKK58_RS04605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKK58_RS04610	COG2076	Multidrug Resistance protein
HKK58_RS04615	COG2076	Multidrug Resistance protein
HKK58_RS04640	COG1024	Enoyl-CoA hydratase
HKK58_RS04645	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS04650	COG1024	Enoyl-CoA hydratase
HKK58_RS04655	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS04660	COG0183	Belongs to the thiolase family
HKK58_RS04670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK58_RS04675	COG3781	membrane
HKK58_RS04685	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HKK58_RS04705	COG0784	Response regulator, receiver
HKK58_RS04705	COG2205	protein histidine kinase activity
HKK58_RS04715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK58_RS04720	COG0784	Response regulator, receiver
HKK58_RS04720	COG2198	Histidine kinase
HKK58_RS04720	COG2205	protein histidine kinase activity
HKK58_RS04755	COG1794	racemase activity, acting on amino acids and derivatives
HKK58_RS04760	COG1247	-acetyltransferase
HKK58_RS04765	COG5342	invasion associated locus B
HKK58_RS04770	COG1929	Belongs to the glycerate kinase type-1 family
HKK58_RS04775	COG3835	regulator
HKK58_RS04780	COG2271	Major facilitator Superfamily
HKK58_RS04790	COG0583	DNA-binding transcription factor activity
HKK58_RS04795	COG0667	Aldo Keto reductase
HKK58_RS04815	COG0583	DNA-binding transcription factor activity
HKK58_RS04820	COG2200	EAL domain
HKK58_RS04900	COG3145	DNA-N1-methyladenine dioxygenase activity
HKK58_RS04905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKK58_RS04905	COG2169	Transcriptional regulator
HKK58_RS04935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HKK58_RS04945	COG0488	(ABC) transporter
HKK58_RS04970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKK58_RS04980	COG0640	Transcriptional regulator
HKK58_RS04995	COG2207	Transcriptional regulator
HKK58_RS04995	COG1917	Cupin 2, conserved barrel domain protein
HKK58_RS05070	COG2135	peptidase activity
HKK58_RS05080	COG3179	chitinase
HKK58_RS05450	COG0270	DNA (cytosine-5-)-methyltransferase activity
HKK58_RS05525	COG0596	Alpha beta hydrolase
HKK58_RS05530	COG5002	protein histidine kinase activity
HKK58_RS05570	COG0583	DNA-binding transcription factor activity
HKK58_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS05595	COG0531	amino acid
HKK58_RS05600	COG3938	Belongs to the proline racemase family
HKK58_RS05605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK58_RS05615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS05620	COG1397	ADP-ribosylglycohydrolase
HKK58_RS05635	COG2267	carboxylic ester hydrolase activity
HKK58_RS05650	COG1309	transcriptional regulator
HKK58_RS05670	COG0583	DNA-binding transcription factor activity
HKK58_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS05710	COG2366	antibiotic biosynthetic process
HKK58_RS05730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK58_RS05735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS05740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS05740	COG1116	anion transmembrane transporter activity
HKK58_RS05760	COG0583	DNA-binding transcription factor activity
HKK58_RS05765	COG0667	Aldo Keto reductase
HKK58_RS05785	COG1238	metal cluster binding
HKK58_RS05790	COG0596	Alpha beta hydrolase
HKK58_RS05795	COG0596	Alpha beta hydrolase
HKK58_RS05800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK58_RS05805	COG0297	glycogen (starch) synthase activity
HKK58_RS05810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKK58_RS05815	COG1640	4-alpha-glucanotransferase
HKK58_RS05875	COG0840	transmembrane signaling receptor activity
HKK58_RS05890	COG1846	Transcriptional regulator
HKK58_RS05910	COG0640	Transcriptional regulator
HKK58_RS05930	COG1024	Enoyl-CoA hydratase
HKK58_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS05975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK58_RS05985	COG0626	cystathionine gamma-synthase activity
HKK58_RS05990	COG1944	ATP diphosphatase activity
HKK58_RS05995	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS06015	COG1309	transcriptional regulator
HKK58_RS06025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS06045	COG1335	isochorismatase
HKK58_RS06050	COG0183	Belongs to the thiolase family
HKK58_RS06060	COG0667	Aldo Keto reductase
HKK58_RS06105	COG0583	DNA-binding transcription factor activity
HKK58_RS06145	COG1846	Transcriptional regulator
HKK58_RS06145	COG0456	acetyltransferase
HKK58_RS06150	COG2271	Major facilitator Superfamily
HKK58_RS06155	COG0519	Catalyzes the synthesis of GMP from XMP
HKK58_RS06170	COG2207	Transcriptional regulator
HKK58_RS06175	COG2223	nitrite transmembrane transporter activity
HKK58_RS06180	COG3706	GGDEF domain
HKK58_RS06195	COG0154	amidase activity
HKK58_RS06220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS06225	COG0697	spore germination
HKK58_RS06285	COG2079	MmgE PrpD family protein
HKK58_RS06290	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS06295	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HKK58_RS06300	COG0583	DNA-binding transcription factor activity
HKK58_RS06305	COG3791	Glutathione-dependent formaldehyde-activating
HKK58_RS06320	COG2205	protein histidine kinase activity
HKK58_RS06325	COG0745	RESPONSE REGULATOR receiver
HKK58_RS06340	COG0589	response to stress
HKK58_RS06365	COG0814	amino acid
HKK58_RS06380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK58_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS06400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK58_RS06415	COG2818	Glycosylase
HKK58_RS06450	COG0714	Associated with various cellular activities
HKK58_RS06485	COG0420	3'-5' exonuclease activity
HKK58_RS06505	COG2706	6-phosphogluconolactonase activity
HKK58_RS06530	COG0673	inositol 2-dehydrogenase activity
HKK58_RS06540	COG2233	PERMEase
HKK58_RS06555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK58_RS06560	COG0583	DNA-binding transcription factor activity
HKK58_RS06625	COG2204	response regulator
HKK58_RS06635	COG0561	phosphatase activity
HKK58_RS06640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HKK58_RS06645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HKK58_RS06655	COG2194	sulfuric ester hydrolase activity
HKK58_RS06670	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK58_RS06685	COG0667	Aldo Keto reductase
HKK58_RS06690	COG0308	aminopeptidase N
HKK58_RS06700	COG3139	Protein of unknown function (DUF1315)
HKK58_RS06710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKK58_RS06715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKK58_RS06785	COG1309	transcriptional regulator
HKK58_RS06790	COG0534	Mate efflux family protein
HKK58_RS06805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK58_RS06855	COG1414	Transcriptional regulator
HKK58_RS06860	COG3842	ATPase activity
HKK58_RS06865	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK58_RS06870	COG1177	transmembrane transport
HKK58_RS06895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKK58_RS06980	COG0583	DNA-binding transcription factor activity
HKK58_RS06995	COG2207	Transcriptional regulator
HKK58_RS07060	COG0583	DNA-binding transcription factor activity
HKK58_RS07075	COG0318	PFAM AMP-dependent synthetase and ligase
HKK58_RS07090	COG0688	phosphatidylethanolamine metabolic process
HKK58_RS07100	COG2814	Major facilitator Superfamily
HKK58_RS07105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK58_RS07110	COG1024	Enoyl-CoA hydratase
HKK58_RS07115	COG1971	Probably functions as a manganese efflux pump
HKK58_RS07120	COG1064	alcohol dehydrogenase
HKK58_RS07130	COG3321	synthase
HKK58_RS07130	COG0604	alcohol dehydrogenase
HKK58_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS07135	COG1902	pentaerythritol trinitrate reductase activity
HKK58_RS07145	COG1309	transcriptional regulator
HKK58_RS07160	COG1968	undecaprenyl-diphosphatase activity
HKK58_RS07170	COG0430	RNA-3'-phosphate cyclase activity
HKK58_RS07175	COG3541	Predicted nucleotidyltransferase
HKK58_RS07180	COG1690	Belongs to the RtcB family
HKK58_RS07185	COG4650	regulator
HKK58_RS07190	COG0625	glutathione transferase activity
HKK58_RS07220	COG2207	Transcriptional regulator
HKK58_RS07245	COG1879	ABC-type sugar transport system periplasmic component
HKK58_RS07255	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS07310	COG3781	membrane
HKK58_RS07345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKK58_RS07425	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HKK58_RS07430	COG2267	carboxylic ester hydrolase activity
HKK58_RS07450	COG2135	peptidase activity
HKK58_RS07455	COG3545	Serine hydrolase
HKK58_RS07490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HKK58_RS07495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK58_RS07500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HKK58_RS07505	COG2835	tetraacyldisaccharide 4'-kinase activity
HKK58_RS07510	COG1663	tetraacyldisaccharide 4'-kinase activity
HKK58_RS07520	COG0811	peptide transport
HKK58_RS07525	COG2333	competence protein COMEC
HKK58_RS07525	COG0658	competence protein
HKK58_RS07545	COG0784	Response regulator, receiver
HKK58_RS07545	COG2205	protein histidine kinase activity
HKK58_RS07545	COG5002	protein histidine kinase activity
HKK58_RS07550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK58_RS07570	COG1393	Belongs to the ArsC family
HKK58_RS07590	COG0037	tRNA processing
HKK58_RS07600	COG3091	SprT-like family
HKK58_RS07605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK58_RS07635	COG0435	Glutathione S-transferase
HKK58_RS07640	COG1648	precorrin-2 dehydrogenase activity
HKK58_RS07640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKK58_RS07645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKK58_RS07650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKK58_RS07655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKK58_RS07660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HKK58_RS07665	COG1674	ftsk spoiiie
HKK58_RS07670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HKK58_RS07675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HKK58_RS07680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKK58_RS07685	COG0542	response to heat
HKK58_RS07690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HKK58_RS07695	COG1278	Cold shock
HKK58_RS07715	COG0482	sulfurtransferase activity
HKK58_RS07720	COG2915	High frequency lysogenization protein hflD homolog
HKK58_RS07730	COG2850	peptidyl-arginine hydroxylation
HKK58_RS07735	COG2153	protein acetylation
HKK58_RS07745	COG2224	Isocitrate lyase
HKK58_RS07750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK58_RS07755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK58_RS07760	COG0649	NAD binding
HKK58_RS07760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK58_RS07775	COG1034	ATP synthesis coupled electron transport
HKK58_RS07780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HKK58_RS07785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK58_RS07795	COG0713	ATP synthesis coupled electron transport
HKK58_RS07810	COG1007	ATP synthesis coupled electron transport
HKK58_RS07845	COG3501	Rhs element vgr protein
HKK58_RS07925	COG5383	Protein conserved in bacteria
HKK58_RS07945	COG0784	Response regulator, receiver
HKK58_RS07945	COG4191	Histidine kinase
HKK58_RS07950	COG0587	DNA-directed DNA polymerase activity
HKK58_RS07965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKK58_RS07975	COG0277	FAD linked oxidase domain protein
HKK58_RS08025	COG2814	Major facilitator Superfamily
HKK58_RS08035	COG3220	belongs to the UPF0276 family
HKK58_RS08075	COG4792	protein secretion
HKK58_RS08080	COG4791	protein targeting
HKK58_RS08090	COG4790	Type iii secretion
HKK58_RS08095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HKK58_RS08150	COG4964	Belongs to the GSP D family
HKK58_RS08155	COG4789	Type iii secretion
HKK58_RS08210	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS08235	COG0577	efflux transmembrane transporter activity
HKK58_RS08235	COG1136	(ABC) transporter
HKK58_RS08240	COG1136	(ABC) transporter
HKK58_RS08240	COG0577	efflux transmembrane transporter activity
HKK58_RS08250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS08315	COG2111	Na H antiporter
HKK58_RS08315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKK58_RS08320	COG1006	Multisubunit Na H antiporter MnhC subunit
HKK58_RS08325	COG0651	ATP synthesis coupled electron transport
HKK58_RS08330	COG1863	multisubunit Na H antiporter MnhE subunit
HKK58_RS08335	COG2212	antiporter activity
HKK58_RS08340	COG1320	monovalent cation:proton antiporter activity
HKK58_RS08355	COG3340	Belongs to the peptidase S51 family
HKK58_RS08365	COG0215	cysteine-tRNA ligase activity
HKK58_RS08370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK58_RS08380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK58_RS08385	COG2814	Major facilitator Superfamily
HKK58_RS08390	COG1566	PFAM secretion protein HlyD family protein
HKK58_RS08400	COG1846	Transcriptional regulator
HKK58_RS08410	COG0729	surface antigen
HKK58_RS08420	COG0708	Exodeoxyribonuclease III
HKK58_RS08425	COG2885	chlorophyll binding
HKK58_RS08430	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS08440	COG0789	Transcriptional regulator
HKK58_RS08450	COG0318	PFAM AMP-dependent synthetase and ligase
HKK58_RS08455	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS08460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKK58_RS08465	COG1024	Enoyl-CoA hydratase
HKK58_RS08485	COG2866	Carboxypeptidase
HKK58_RS08490	COG3038	cytochrome b561
HKK58_RS08545	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK58_RS08555	COG0217	transcriptional regulatory protein
HKK58_RS08560	COG0583	DNA-binding transcription factor activity
HKK58_RS08565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HKK58_RS08570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK58_RS08575	COG3038	cytochrome b561
HKK58_RS08585	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK58_RS08585	COG1902	pentaerythritol trinitrate reductase activity
HKK58_RS08600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HKK58_RS08605	COG1846	Transcriptional regulator
HKK58_RS08610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HKK58_RS08620	COG0583	DNA-binding transcription factor activity
HKK58_RS08630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK58_RS08635	COG0776	regulation of translation
HKK58_RS08640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKK58_RS08645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKK58_RS08650	COG0740	serine-type endopeptidase activity
HKK58_RS08655	COG0544	peptidyl-prolyl cis-trans isomerase activity
HKK58_RS08680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKK58_RS08690	COG1686	Belongs to the peptidase S11 family
HKK58_RS08715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS08735	COG1953	Uracil, thiamine, allantoin
HKK58_RS08745	COG0493	'glutamate synthase
HKK58_RS08745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKK58_RS08755	COG1309	transcriptional regulator
HKK58_RS08770	COG1276	copper resistance
HKK58_RS08780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK58_RS08790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HKK58_RS08830	COG0640	Transcriptional regulator
HKK58_RS08840	COG1522	sequence-specific DNA binding
HKK58_RS08845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKK58_RS08850	COG0022	dehydrogenase e1 component
HKK58_RS08860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK58_RS08865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKK58_RS08870	COG0456	acetyltransferase
HKK58_RS08895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS08900	COG0577	efflux transmembrane transporter activity
HKK58_RS08900	COG1136	(ABC) transporter
HKK58_RS08925	COG1609	Transcriptional regulator
HKK58_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS08935	COG1070	Carbohydrate kinase
HKK58_RS08940	COG1063	alcohol dehydrogenase
HKK58_RS08945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK58_RS08955	COG1879	ABC-type sugar transport system periplasmic component
HKK58_RS08995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKK58_RS09000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HKK58_RS09015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK58_RS09020	COG0601	transmembrane transport
HKK58_RS09025	COG0747	negative chemotaxis
HKK58_RS09035	COG3191	aminopeptidase activity
HKK58_RS09040	COG4206	TonB-dependent receptor
HKK58_RS09045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS09050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HKK58_RS09055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS09060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS09070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS09100	COG0583	DNA-binding transcription factor activity
HKK58_RS09105	COG0583	DNA-binding transcription factor activity
HKK58_RS09110	COG0625	glutathione transferase activity
HKK58_RS09115	COG0583	DNA-binding transcription factor activity
HKK58_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS09130	COG1063	alcohol dehydrogenase
HKK58_RS09135	COG0390	transport system, permease component
HKK58_RS09140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK58_RS09145	COG0667	Aldo Keto reductase
HKK58_RS09160	COG0243	molybdopterin cofactor binding
HKK58_RS09170	COG3121	Chaperone
HKK58_RS09180	COG0784	Response regulator, receiver
HKK58_RS09180	COG2205	protein histidine kinase activity
HKK58_RS09185	COG2200	EAL domain
HKK58_RS09185	COG2203	Gaf domain
HKK58_RS09185	COG2199	diguanylate cyclase activity
HKK58_RS09190	COG2205	protein histidine kinase activity
HKK58_RS09190	COG0784	Response regulator, receiver
HKK58_RS09195	COG2197	response regulator
HKK58_RS09205	COG3121	Chaperone
HKK58_RS09235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS09245	COG1231	oxidoreductase activity
HKK58_RS09255	COG1126	abc transporter atp-binding protein
HKK58_RS09270	COG1450	Type ii and iii secretion system protein
HKK58_RS09290	COG3156	type II secretion system protein K
HKK58_RS09310	COG2165	general secretion pathway protein
HKK58_RS09315	COG1459	type II secretion system
HKK58_RS09320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKK58_RS09325	COG1609	Transcriptional regulator
HKK58_RS09335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS09340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS09345	COG1120	ATPase activity
HKK58_RS09350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK58_RS09355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK58_RS09360	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HKK58_RS09365	COG4774	siderophore transport
HKK58_RS09390	COG0776	regulation of translation
HKK58_RS09395	COG0072	phenylalanine-tRNA ligase activity
HKK58_RS09400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKK58_RS09405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKK58_RS09410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HKK58_RS09415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKK58_RS09420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKK58_RS09430	COG1278	Cold shock
HKK58_RS09455	COG1869	D-ribose catabolic process
HKK58_RS09460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK58_RS09465	COG1609	Transcriptional regulator
HKK58_RS09470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK58_RS09475	COG1129	ABC transporter
HKK58_RS09480	COG1879	ABC-type sugar transport system periplasmic component
HKK58_RS09505	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK58_RS09555	COG0454	-acetyltransferase
HKK58_RS09560	COG1940	carbohydrate kinase activity
HKK58_RS09570	COG1940	carbohydrate kinase activity
HKK58_RS09575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKK58_RS09580	COG0477	Major facilitator Superfamily
HKK58_RS09595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS09630	COG1286	toxin biosynthetic process
HKK58_RS09635	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKK58_RS09640	COG0285	dihydrofolate synthase activity
HKK58_RS09645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HKK58_RS09650	COG0135	phosphoribosylanthranilate isomerase activity
HKK58_RS09675	COG0473	3-isopropylmalate dehydrogenase activity
HKK58_RS09680	COG2226	methyltransferase
HKK58_RS09685	COG0066	3-isopropylmalate dehydratase activity
HKK58_RS09690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKK58_RS09720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKK58_RS09730	COG0596	Alpha beta hydrolase
HKK58_RS09765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK58_RS09770	COG0556	nucleotide-excision repair
HKK58_RS09785	COG0583	DNA-binding transcription factor activity
HKK58_RS09790	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS09800	COG2205	protein histidine kinase activity
HKK58_RS09805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HKK58_RS09815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKK58_RS09820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK58_RS09825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HKK58_RS09850	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HKK58_RS09915	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS09930	COG4172	Belongs to the ABC transporter superfamily
HKK58_RS09935	COG4239	(ABC) transporter, permease
HKK58_RS09940	COG4174	ABC transporter (Permease)
HKK58_RS09945	COG4166	transmembrane transport
HKK58_RS09950	COG4206	TonB-dependent receptor
HKK58_RS09950	COG4206	TonB-dependent receptor
HKK58_RS09960	COG3712	iron ion homeostasis
HKK58_RS09965	COG1595	DNA-templated transcription, initiation
HKK58_RS09970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK58_RS10005	COG2384	SAM-dependent methyltransferase
HKK58_RS10010	COG2186	Transcriptional regulator
HKK58_RS10030	COG3657	addiction module killer protein
HKK58_RS10035	COG4521	taurine ABC transporter
HKK58_RS10055	COG0235	Class ii aldolase
HKK58_RS10065	COG5285	phytanoyl-CoA dioxygenase
HKK58_RS10070	COG1126	abc transporter atp-binding protein
HKK58_RS10075	COG0583	DNA-binding transcription factor activity
HKK58_RS10085	COG1063	alcohol dehydrogenase
HKK58_RS10125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK58_RS10135	COG0730	response to heat
HKK58_RS10140	COG1104	cysteine desulfurase activity
HKK58_RS10185	COG0402	S-adenosylhomocysteine deaminase activity
HKK58_RS10195	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HKK58_RS10205	COG0583	DNA-binding transcription factor activity
HKK58_RS10215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS10220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HKK58_RS10245	COG0477	Major facilitator Superfamily
HKK58_RS10250	COG1984	allophanate hydrolase subunit 2
HKK58_RS10255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HKK58_RS10270	COG2391	methyltransferase activity
HKK58_RS10280	COG1335	isochorismatase
HKK58_RS10295	COG4993	Dehydrogenase
HKK58_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS10305	COG0583	DNA-binding transcription factor activity
HKK58_RS10310	COG2814	Major facilitator Superfamily
HKK58_RS10315	COG1309	transcriptional regulator
HKK58_RS10335	COG4772	TonB-dependent receptor
HKK58_RS10340	COG3712	iron ion homeostasis
HKK58_RS10345	COG1595	DNA-templated transcription, initiation
HKK58_RS10355	COG0583	DNA-binding transcription factor activity
HKK58_RS10360	COG1304	FMN binding
HKK58_RS10365	COG3706	GGDEF domain
HKK58_RS10375	COG5002	protein histidine kinase activity
HKK58_RS10375	COG5001	Diguanylate cyclase
HKK58_RS10395	COG0271	Belongs to the BolA IbaG family
HKK58_RS10405	COG0114	fumarate hydratase activity
HKK58_RS10410	COG0697	spore germination
HKK58_RS10415	COG0183	Belongs to the thiolase family
HKK58_RS10420	COG2326	polyphosphate kinase activity
HKK58_RS10425	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HKK58_RS10425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS10435	COG0367	asparagine synthase
HKK58_RS10440	COG0189	ligase activity
HKK58_RS10440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKK58_RS10450	COG3089	Belongs to the UPF0270 family
HKK58_RS10455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK58_RS10470	COG1368	sulfuric ester hydrolase activity
HKK58_RS10490	COG0318	PFAM AMP-dependent synthetase and ligase
HKK58_RS10500	COG2197	response regulator
HKK58_RS10505	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HKK58_RS10515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKK58_RS10520	COG1073	alpha beta
HKK58_RS10545	COG2840	Smr protein MutS2
HKK58_RS10550	COG0302	gtp cyclohydrolase
HKK58_RS10570	COG2851	Citrate transporter
HKK58_RS10575	COG0583	DNA-binding transcription factor activity
HKK58_RS10580	COG0625	glutathione transferase activity
HKK58_RS10585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS10595	COG2252	PERMEase
HKK58_RS10625	COG4266	Belongs to the allantoicase family
HKK58_RS10630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HKK58_RS10640	COG2233	PERMEase
HKK58_RS10655	COG1560	Kdo2-lipid A biosynthetic process
HKK58_RS10660	COG0850	regulation of cytokinetic process
HKK58_RS10665	COG2894	cell division
HKK58_RS10670	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HKK58_RS10675	COG0564	pseudouridine synthase activity
HKK58_RS10680	COG1362	aminopeptidase activity
HKK58_RS10690	COG0668	transmembrane transport
HKK58_RS10695	COG1473	amidohydrolase
HKK58_RS10710	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKK58_RS10715	COG0642	Histidine kinase
HKK58_RS10730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKK58_RS10740	COG3469	chitinase activity
HKK58_RS10745	COG3397	chitin binding
HKK58_RS10785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKK58_RS10790	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS10795	COG1024	Enoyl-CoA hydratase
HKK58_RS10810	COG3123	guanosine phosphorylase activity
HKK58_RS10815	COG3217	Mosc domain protein beta barrel domain protein
HKK58_RS10815	COG0633	Ferredoxin
HKK58_RS10830	COG3851	Histidine kinase
HKK58_RS10835	COG2197	response regulator
HKK58_RS10840	COG1597	lipid kinase activity
HKK58_RS10850	COG0835	chemotaxis
HKK58_RS10860	COG1192	Involved in chromosome partitioning
HKK58_RS10865	COG1360	Flagellar Motor Protein
HKK58_RS10870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HKK58_RS10875	COG2201	protein-glutamate methylesterase activity
HKK58_RS10880	COG2198	Histidine kinase
HKK58_RS10880	COG0643	Histidine kinase
HKK58_RS10880	COG0784	Response regulator, receiver
HKK58_RS10885	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HKK58_RS10915	COG1278	Cold shock
HKK58_RS10925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKK58_RS11010	COG1677	Flagellar hook-basal body complex protein FliE
HKK58_RS11020	COG5002	protein histidine kinase activity
HKK58_RS11065	COG1256	bacterial-type flagellum assembly
HKK58_RS11075	COG1706	bacterial-type flagellum-dependent cell motility
HKK58_RS11080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HKK58_RS11090	COG4787	bacterial-type flagellum-dependent cell motility
HKK58_RS11105	COG2154	pterin-4-alpha-carbinolamine dehydratase
HKK58_RS11120	COG2207	Transcriptional regulator
HKK58_RS11135	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKK58_RS11140	COG1846	Transcriptional regulator
HKK58_RS11145	COG0514	ATP-dependent DNA helicase (RecQ)
HKK58_RS11155	COG2832	Protein of unknown function (DUF454)
HKK58_RS11160	COG0784	Response regulator, receiver
HKK58_RS11160	COG2205	protein histidine kinase activity
HKK58_RS11205	COG1846	Transcriptional regulator
HKK58_RS11210	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HKK58_RS11215	COG0406	alpha-ribazole phosphatase activity
HKK58_RS11220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HKK58_RS11230	COG1492	cobalamin metabolic process
HKK58_RS11240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HKK58_RS11245	COG0778	Nitroreductase
HKK58_RS11250	COG1797	cobyrinic acid a,c-diamide synthase activity
HKK58_RS11265	COG0791	NLP P60 protein
HKK58_RS11270	COG0791	NLP P60 protein
HKK58_RS11275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKK58_RS11280	COG0628	permease
HKK58_RS11290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HKK58_RS11295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKK58_RS11310	COG3122	Protein conserved in bacteria
HKK58_RS11315	COG3956	TIGRFAM MazG family protein
HKK58_RS11320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKK58_RS11325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK58_RS11360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK58_RS11365	COG0583	DNA-binding transcription factor activity
HKK58_RS11375	COG1953	Uracil, thiamine, allantoin
HKK58_RS11385	COG2996	Protein conserved in bacteria
HKK58_RS11415	COG0513	Belongs to the DEAD box helicase family
HKK58_RS11420	COG0668	transmembrane transport
HKK58_RS11430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK58_RS11455	COG1132	(ABC) transporter
HKK58_RS11460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKK58_RS11470	COG2188	Transcriptional regulator
HKK58_RS11480	COG1595	DNA-templated transcription, initiation
HKK58_RS11490	COG1643	Atp-dependent helicase
HKK58_RS11495	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HKK58_RS11500	COG0840	transmembrane signaling receptor activity
HKK58_RS11550	COG1696	Membrane protein involved in D-alanine export
HKK58_RS11615	COG0840	transmembrane signaling receptor activity
HKK58_RS11625	COG3278	Belongs to the heme-copper respiratory oxidase family
HKK58_RS11640	COG2010	Cytochrome c
HKK58_RS11645	COG3278	Belongs to the heme-copper respiratory oxidase family
HKK58_RS11660	COG2010	Cytochrome c
HKK58_RS11665	COG0348	domain, Protein
HKK58_RS11700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK58_RS11705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKK58_RS11710	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS11715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKK58_RS11720	COG2130	NADP-dependent
HKK58_RS11725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKK58_RS11730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKK58_RS11750	COG0583	DNA-binding transcription factor activity
HKK58_RS11790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKK58_RS11795	COG3115	cell septum assembly
HKK58_RS11815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK58_RS11825	COG0402	S-adenosylhomocysteine deaminase activity
HKK58_RS11830	COG1802	Transcriptional regulator
HKK58_RS11835	COG3135	benzoate transporter
HKK58_RS11840	COG3171	Protein conserved in bacteria
HKK58_RS11850	COG3706	GGDEF domain
HKK58_RS11855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK58_RS11855	COG0116	Belongs to the methyltransferase superfamily
HKK58_RS11860	COG3130	regulation of translation
HKK58_RS11865	COG0167	dihydroorotate dehydrogenase activity
HKK58_RS11885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS11885	COG1116	anion transmembrane transporter activity
HKK58_RS11890	COG3707	response regulator
HKK58_RS11895	COG2223	nitrite transmembrane transporter activity
HKK58_RS11905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK58_RS11910	COG2146	nitrite reductase [NAD(P)H] activity
HKK58_RS11915	COG0243	molybdopterin cofactor binding
HKK58_RS11920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKK58_RS11925	COG3047	cAMP biosynthetic process
HKK58_RS11925	COG2885	chlorophyll binding
HKK58_RS11950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKK58_RS11965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HKK58_RS11970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS11985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKK58_RS11990	COG1045	serine acetyltransferase
HKK58_RS11995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKK58_RS12010	COG1116	anion transmembrane transporter activity
HKK58_RS12015	COG2079	MmgE PrpD family protein
HKK58_RS12025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKK58_RS12030	COG0372	Belongs to the citrate synthase family
HKK58_RS12040	COG1802	Transcriptional regulator
HKK58_RS12045	COG0189	ligase activity
HKK58_RS12045	COG4067	protein conserved in archaea
HKK58_RS12055	COG0189	ligase activity
HKK58_RS12060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKK58_RS12065	COG0560	Phosphoserine phosphatase
HKK58_RS12075	COG1953	Uracil, thiamine, allantoin
HKK58_RS12085	COG0583	DNA-binding transcription factor activity
HKK58_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS12095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK58_RS12100	COG0300	oxidoreductase activity
HKK58_RS12105	COG0583	DNA-binding transcription factor activity
HKK58_RS12180	COG0598	Magnesium transport protein CorA
HKK58_RS12185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKK58_RS12185	COG0519	Catalyzes the synthesis of GMP from XMP
HKK58_RS12190	COG1024	Enoyl-CoA hydratase
HKK58_RS12190	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK58_RS12195	COG0183	Belongs to the thiolase family
HKK58_RS12205	COG1305	Transglutaminase-like
HKK58_RS12215	COG2308	Evidence 4 Homologs of previously reported genes of
HKK58_RS12245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS12250	COG2885	chlorophyll binding
HKK58_RS12280	COG2207	Transcriptional regulator
HKK58_RS12285	COG1064	alcohol dehydrogenase
HKK58_RS12290	COG1414	Transcriptional regulator
HKK58_RS12295	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK58_RS12300	COG1129	ABC transporter
HKK58_RS12305	COG1879	ABC-type sugar transport system periplasmic component
HKK58_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS12355	COG1397	ADP-ribosylglycohydrolase
HKK58_RS12360	COG2188	Transcriptional regulator
HKK58_RS12375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKK58_RS12385	COG0084	hydrolase, TatD family'
HKK58_RS12395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKK58_RS12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKK58_RS12410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK58_RS12415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK58_RS12430	COG0416	fatty acid biosynthetic process
HKK58_RS12435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HKK58_RS12445	COG0424	maF-like protein
HKK58_RS12450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK58_RS12450	COG0616	signal peptide processing
HKK58_RS12455	COG0546	phosphoglycolate phosphatase activity
HKK58_RS12465	COG1530	ribonuclease E activity
HKK58_RS12470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK58_RS12475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKK58_RS12475	COG3608	succinylglutamate desuccinylase aspartoacylase
HKK58_RS12480	COG1301	dicarboxylic acid transport
HKK58_RS12485	COG1917	Cupin 2, conserved barrel domain protein
HKK58_RS12485	COG4977	sequence-specific DNA binding
HKK58_RS12495	COG0745	RESPONSE REGULATOR receiver
HKK58_RS12510	COG2205	protein histidine kinase activity
HKK58_RS12515	COG0745	RESPONSE REGULATOR receiver
HKK58_RS12535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HKK58_RS12540	COG1558	bacterial-type flagellum-dependent cell motility
HKK58_RS12545	COG1815	bacterial-type flagellum-dependent cell motility
HKK58_RS12550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK58_RS12555	COG0835	chemotaxis
HKK58_RS12555	COG0784	Response regulator, receiver
HKK58_RS12575	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HKK58_RS12580	COG0477	Major facilitator Superfamily
HKK58_RS12605	COG2239	Acts as a magnesium transporter
HKK58_RS12625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK58_RS12630	COG0527	aspartate kinase activity
HKK58_RS12635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKK58_RS12640	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HKK58_RS12645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HKK58_RS12655	COG2988	succinylglutamate desuccinylase activity
HKK58_RS12665	COG3724	N-succinylarginine dihydrolase activity
HKK58_RS12670	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS12685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK58_RS12720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS12725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK58_RS12735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK58_RS12755	COG0165	Argininosuccinate lyase
HKK58_RS12760	COG0765	amino acid transport
HKK58_RS12775	COG2814	Major facilitator Superfamily
HKK58_RS12790	COG0563	adenylate kinase activity
HKK58_RS12800	COG4221	oxidoreductase activity
HKK58_RS12820	COG3706	GGDEF domain
HKK58_RS12835	COG0583	DNA-binding transcription factor activity
HKK58_RS12840	COG0504	CTP synthase activity
HKK58_RS12845	COG2329	Antibiotic biosynthesis monooxygenase
HKK58_RS12855	COG0584	glycerophosphoryl diester phosphodiesterase
HKK58_RS12875	COG0306	phosphate transporter
HKK58_RS12880	COG1984	allophanate hydrolase subunit 2
HKK58_RS12890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HKK58_RS12900	COG0583	DNA-binding transcription factor activity
HKK58_RS12905	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS12920	COG0583	DNA-binding transcription factor activity
HKK58_RS12925	COG0583	DNA-binding transcription factor activity
HKK58_RS12930	COG4221	oxidoreductase activity
HKK58_RS12935	COG4941	Belongs to the sigma-70 factor family
HKK58_RS12945	COG3795	YCII-related domain
HKK58_RS12970	COG0436	Aminotransferase
HKK58_RS12980	COG3265	gluconokinase activity
HKK58_RS12985	COG1609	Transcriptional regulator
HKK58_RS12995	COG0583	DNA-binding transcription factor activity
HKK58_RS13010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK58_RS13015	COG2271	Major facilitator Superfamily
HKK58_RS13030	COG0583	DNA-binding transcription factor activity
HKK58_RS13035	COG0625	glutathione transferase activity
HKK58_RS13040	COG2986	histidine ammonia-lyase
HKK58_RS13050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS13065	COG3712	iron ion homeostasis
HKK58_RS13070	COG1595	DNA-templated transcription, initiation
HKK58_RS13095	COG0242	peptide deformylase activity
HKK58_RS13100	COG1295	ribonuclease BN
HKK58_RS13120	COG0318	PFAM AMP-dependent synthetase and ligase
HKK58_RS13130	COG2030	dehydratase
HKK58_RS13140	COG3530	Putative quorum-sensing-regulated virulence factor
HKK58_RS13145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKK58_RS13150	COG0800	Aldolase
HKK58_RS13165	COG1737	Transcriptional regulator
HKK58_RS13170	COG0676	glucose-6-phosphate 1-epimerase activity
HKK58_RS13180	COG3842	ATPase activity
HKK58_RS13190	COG1175	transmembrane transport
HKK58_RS13195	COG1653	transport
HKK58_RS13210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK58_RS13215	COG0583	DNA-binding transcription factor activity
HKK58_RS13230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKK58_RS13250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKK58_RS13285	COG1113	amino acid transport
HKK58_RS13310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKK58_RS13320	COG0009	L-threonylcarbamoyladenylate synthase
HKK58_RS13330	COG2917	probably involved in intracellular septation
HKK58_RS13335	COG2350	Protein conserved in bacteria
HKK58_RS13345	COG0745	RESPONSE REGULATOR receiver
HKK58_RS13355	COG0642	Histidine kinase
HKK58_RS13405	COG0509	glycine decarboxylation via glycine cleavage system
HKK58_RS13410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKK58_RS13410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKK58_RS13415	COG1760	l-serine dehydratase
HKK58_RS13420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK58_RS13425	COG1278	Cold shock
HKK58_RS13435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKK58_RS13470	COG0573	inorganic phosphate transmembrane transporter activity
HKK58_RS13480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK58_RS13490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKK58_RS13495	COG0602	queuosine metabolic process
HKK58_RS13500	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HKK58_RS13505	COG2885	chlorophyll binding
HKK58_RS13510	COG0823	Involved in the tonB-independent uptake of proteins
HKK58_RS13530	COG0824	Thioesterase
HKK58_RS13535	COG2255	four-way junction helicase activity
HKK58_RS13540	COG0632	four-way junction helicase activity
HKK58_RS13545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HKK58_RS13550	COG0217	transcriptional regulatory protein
HKK58_RS13555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HKK58_RS13570	COG0783	Belongs to the Dps family
HKK58_RS13580	COG2900	Belongs to the SlyX family
HKK58_RS13595	COG0668	transmembrane transport
HKK58_RS13600	COG1666	GTP binding
HKK58_RS13610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS13610	COG4191	Histidine kinase
HKK58_RS13615	COG2096	Adenosyltransferase
HKK58_RS13625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKK58_RS13630	COG0653	protein targeting
HKK58_RS13640	COG0433	COG0433 Predicted ATPase
HKK58_RS13655	COG0788	formyltetrahydrofolate deformylase activity
HKK58_RS13665	COG2925	Exonuclease
HKK58_RS13690	COG0714	Associated with various cellular activities
HKK58_RS13710	COG0469	pyruvate kinase activity
HKK58_RS13715	COG1024	Enoyl-CoA hydratase
HKK58_RS13730	COG4191	Histidine kinase
HKK58_RS13740	COG0477	Major facilitator Superfamily
HKK58_RS13765	COG2207	Transcriptional regulator
HKK58_RS13775	COG0745	RESPONSE REGULATOR receiver
HKK58_RS13795	COG1595	DNA-templated transcription, initiation
HKK58_RS13800	COG3712	iron ion homeostasis
HKK58_RS13805	COG4771	TonB-dependent receptor
HKK58_RS13815	COG2832	Protein of unknown function (DUF454)
HKK58_RS13820	COG0840	transmembrane signaling receptor activity
HKK58_RS13850	COG3642	lipopolysaccharide core region biosynthetic process
HKK58_RS13875	COG0459	protein refolding
HKK58_RS13880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKK58_RS13910	COG0442	prolyl-tRNA aminoacylation
HKK58_RS13920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKK58_RS13955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK58_RS13985	COG4974	Belongs to the 'phage' integrase family
HKK58_RS13990	COG1607	acyl-coa hydrolase
HKK58_RS13995	COG0335	large ribosomal subunit rRNA binding
HKK58_RS14000	COG0336	Belongs to the RNA methyltransferase TrmD family
HKK58_RS14005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKK58_RS14010	COG0228	four-way junction DNA binding
HKK58_RS14015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKK58_RS14025	COG4536	flavin adenine dinucleotide binding
HKK58_RS14030	COG0477	Major facilitator Superfamily
HKK58_RS14035	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HKK58_RS14055	COG0494	nUDIX hydrolase
HKK58_RS14070	COG2188	Transcriptional regulator
HKK58_RS14075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HKK58_RS14080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKK58_RS14085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK58_RS14085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK58_RS14090	COG2190	(PTS) system
HKK58_RS14090	COG1263	PTS System
HKK58_RS14090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK58_RS14100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKK58_RS14105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKK58_RS14105	COG0047	phosphoribosylformylglycinamidine synthase activity
HKK58_RS14110	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HKK58_RS14120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK58_RS14120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK58_RS14125	COG4580	involved in the transport of maltose and maltodextrins
HKK58_RS14130	COG0366	Alpha amylase catalytic
HKK58_RS14135	COG1263	PTS System
HKK58_RS14135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK58_RS14140	COG2188	Transcriptional regulator
HKK58_RS14195	COG5314	conjugation
HKK58_RS14240	COG0582	viral genome integration into host DNA
HKK58_RS14245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKK58_RS14245	COG0519	Catalyzes the synthesis of GMP from XMP
HKK58_RS14265	COG0583	DNA-binding transcription factor activity
HKK58_RS14270	COG1570	exodeoxyribonuclease VII activity
HKK58_RS14275	COG0739	heme binding
HKK58_RS14280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK58_RS14285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK58_RS14290	COG0436	Aminotransferase
HKK58_RS14295	COG1160	GTP binding
HKK58_RS14310	COG0124	histidyl-tRNA synthetase
HKK58_RS14315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKK58_RS14320	COG1426	Protein conserved in bacteria
HKK58_RS14330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HKK58_RS14335	COG0105	UTP biosynthetic process
HKK58_RS14345	COG0633	Ferredoxin
HKK58_RS14350	COG0443	Heat shock 70 kDa protein
HKK58_RS14355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HKK58_RS14360	COG0316	Belongs to the HesB IscA family
HKK58_RS14370	COG1104	cysteine desulfurase activity
HKK58_RS14395	COG3134	Outer membrane lipoprotein
HKK58_RS14410	COG1862	Preprotein translocase
HKK58_RS14415	COG0343	queuine tRNA-ribosyltransferase activity
HKK58_RS14420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HKK58_RS14435	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS14460	COG0642	Histidine kinase
HKK58_RS14465	COG0745	RESPONSE REGULATOR receiver
HKK58_RS14510	COG4251	negative regulation of phosphorylation
HKK58_RS14525	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HKK58_RS14535	COG3706	GGDEF domain
HKK58_RS14540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS14545	COG0583	DNA-binding transcription factor activity
HKK58_RS14550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK58_RS14585	COG0506	proline dehydrogenase activity
HKK58_RS14600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKK58_RS14605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKK58_RS14610	COG0109	protoheme IX farnesyltransferase activity
HKK58_RS14625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKK58_RS14630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKK58_RS14635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HKK58_RS14640	COG1017	nitric oxide dioxygenase activity
HKK58_RS14640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK58_RS14645	COG3604	Transcriptional regulator
HKK58_RS14655	COG3708	Transcriptional regulator
HKK58_RS14655	COG2207	Transcriptional regulator
HKK58_RS14660	COG2197	response regulator
HKK58_RS14675	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS14680	COG0596	Alpha beta hydrolase
HKK58_RS14690	COG1346	cytolysis
HKK58_RS14700	COG0583	DNA-binding transcription factor activity
HKK58_RS14710	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK58_RS14735	COG0302	gtp cyclohydrolase
HKK58_RS14740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKK58_RS14755	COG0492	ferredoxin-NADP+ reductase activity
HKK58_RS14760	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HKK58_RS14775	COG0386	Belongs to the glutathione peroxidase family
HKK58_RS14780	COG3045	CreA protein
HKK58_RS14785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKK58_RS14790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKK58_RS14795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HKK58_RS14800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HKK58_RS14805	COG0142	geranyltranstransferase activity
HKK58_RS14810	COG2824	Alkylphosphonate utilization operon protein PhnA
HKK58_RS14815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK58_RS14820	COG0545	Peptidyl-prolyl cis-trans isomerase
HKK58_RS14825	COG0840	transmembrane signaling receptor activity
HKK58_RS14835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HKK58_RS14845	COG2610	gluconate transmembrane transporter activity
HKK58_RS14855	COG0659	secondary active sulfate transmembrane transporter activity
HKK58_RS14890	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS14900	COG0583	DNA-binding transcription factor activity
HKK58_RS14905	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK58_RS14915	COG0583	DNA-binding transcription factor activity
HKK58_RS14920	COG1113	amino acid transport
HKK58_RS14930	COG1522	sequence-specific DNA binding
HKK58_RS14935	COG3485	protocatechuate 3,4-dioxygenase
HKK58_RS14940	COG4829	muconolactone delta-isomerase
HKK58_RS14945	COG4948	Mandelate Racemase Muconate Lactonizing
HKK58_RS14960	COG4638	Rieske (2fe-2S)
HKK58_RS14965	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HKK58_RS14970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK58_RS14970	COG0543	2 iron, 2 sulfur cluster binding
HKK58_RS14975	COG1113	amino acid transport
HKK58_RS14980	COG3483	tryptophan 2,3-dioxygenase activity
HKK58_RS14985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HKK58_RS15030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKK58_RS15035	COG1074	ATP-dependent DNA helicase activity
HKK58_RS15040	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HKK58_RS15070	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HKK58_RS15075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKK58_RS15080	COG1183	phosphatidylcholine synthase activity
HKK58_RS15085	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKK58_RS15095	COG0028	Belongs to the TPP enzyme family
HKK58_RS15100	COG3098	single-species biofilm formation
HKK58_RS15110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK58_RS15130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HKK58_RS15135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK58_RS15140	COG4558	Periplasmic binding protein
HKK58_RS15150	COG1489	DNA binding
HKK58_RS15165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK58_RS15175	COG4191	Histidine kinase
HKK58_RS15195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HKK58_RS15200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HKK58_RS15205	COG0166	Belongs to the GPI family
HKK58_RS15210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK58_RS15220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK58_RS15230	COG2823	Periplasmic or secreted lipoprotein
HKK58_RS15235	COG1185	polyribonucleotide nucleotidyltransferase activity
HKK58_RS15240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKK58_RS15245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKK58_RS15250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKK58_RS15255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKK58_RS15260	COG0195	Participates in both transcription termination and antitermination
HKK58_RS15265	COG0779	Required for maturation of 30S ribosomal subunits
HKK58_RS15280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKK58_RS15285	COG0149	triose-phosphate isomerase activity
HKK58_RS15290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK58_RS15295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKK58_RS15305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HKK58_RS15320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK58_RS15325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HKK58_RS15330	COG0505	Belongs to the CarA family
HKK58_RS15335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HKK58_RS15340	COG0484	heat shock protein binding
HKK58_RS15345	COG0443	Heat shock 70 kDa protein
HKK58_RS15350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HKK58_RS15355	COG0497	DNA recombination
HKK58_RS15360	COG0735	belongs to the Fur family
HKK58_RS15365	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKK58_RS15370	COG2914	Belongs to the UPF0125 (RnfH) family
HKK58_RS15380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HKK58_RS15385	COG2186	Transcriptional regulator
HKK58_RS15390	COG1620	l-lactate permease
HKK58_RS15410	COG0582	viral genome integration into host DNA
HKK58_RS15425	COG3311	Transcriptional regulator
HKK58_RS15460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKK58_RS15465	COG0270	DNA (cytosine-5-)-methyltransferase activity
HKK58_RS15485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK58_RS15490	COG0473	3-isopropylmalate dehydrogenase activity
HKK58_RS15490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKK58_RS15510	COG2862	Uncharacterized protein family, UPF0114
HKK58_RS15525	COG1067	ATP-dependent peptidase activity
HKK58_RS15550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK58_RS15560	COG0488	(ABC) transporter
HKK58_RS15570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKK58_RS15575	COG0523	cobalamin synthesis protein
HKK58_RS15580	COG2879	small protein
HKK58_RS15585	COG1966	Carbon starvation protein
HKK58_RS15615	COG1970	mechanosensitive ion channel activity
HKK58_RS15625	COG2197	response regulator
HKK58_RS15630	COG2813	Specifically methylates the guanine in position
HKK58_RS15640	COG1294	oxidase, subunit
HKK58_RS15645	COG1271	oxidase subunit
HKK58_RS15655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK58_RS15660	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HKK58_RS15665	COG2080	2 iron, 2 sulfur cluster binding
HKK58_RS15675	COG2252	PERMEase
HKK58_RS15680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK58_RS15685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HKK58_RS15690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK58_RS15695	COG1309	transcriptional regulator
HKK58_RS15705	COG0477	Major facilitator Superfamily
HKK58_RS15720	COG2321	neutral zinc metallopeptidase
HKK58_RS15735	COG1946	Acyl-CoA thioesterase
HKK58_RS15745	COG0123	including yeast histone deacetylase and acetoin utilization protein
HKK58_RS15755	COG0513	Belongs to the DEAD box helicase family
HKK58_RS15760	COG0697	spore germination
HKK58_RS15765	COG1522	sequence-specific DNA binding
HKK58_RS15780	COG1199	ATP-dependent helicase activity
HKK58_RS15780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK58_RS15790	COG3416	Protein conserved in bacteria
HKK58_RS15805	COG1643	Atp-dependent helicase
HKK58_RS15815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKK58_RS15825	COG1522	sequence-specific DNA binding
HKK58_RS15840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKK58_RS15845	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS15860	COG0352	thiamine-phosphate diphosphorylase activity
HKK58_RS15865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HKK58_RS15880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKK58_RS15885	COG1702	phosphate starvation-inducible protein PhoH
HKK58_RS15890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKK58_RS15895	COG4535	Mg2 and Co2 transporter CorC
HKK58_RS15900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HKK58_RS15915	COG0495	leucyl-tRNA aminoacylation
HKK58_RS15925	COG1466	dna polymerase III delta subunit
HKK58_RS15935	COG2951	lytic endotransglycosylase activity
HKK58_RS15945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKK58_RS15950	COG0321	lipoyl(octanoyl) transferase activity
HKK58_RS15955	COG2921	Belongs to the UPF0250 family
HKK58_RS15960	COG1686	Belongs to the peptidase S11 family
HKK58_RS15970	COG2951	lytic endotransglycosylase activity
HKK58_RS15975	COG0772	Belongs to the SEDS family
HKK58_RS15980	COG0768	penicillin binding
HKK58_RS15985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HKK58_RS15995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKK58_RS16000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKK58_RS16005	COG2094	Belongs to the DNA glycosylase MPG family
HKK58_RS16010	COG0586	Pfam SNARE associated Golgi protein
HKK58_RS16020	COG1346	cytolysis
HKK58_RS16040	COG0702	epimerase
HKK58_RS16055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKK58_RS16070	COG3284	Transcriptional regulator
HKK58_RS16075	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS16080	COG0531	amino acid
HKK58_RS16085	COG4303	Ethanolamine ammonia lyase large subunit
HKK58_RS16090	COG4302	ethanolamine ammonia-lyase activity
HKK58_RS16095	COG0456	acetyltransferase
HKK58_RS16100	COG0586	Pfam SNARE associated Golgi protein
HKK58_RS16105	COG3228	Belongs to the MtfA family
HKK58_RS16110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKK58_RS16130	COG1335	isochorismatase
HKK58_RS16135	COG0754	glutathionylspermidine amidase activity
HKK58_RS16145	COG3766	membrane
HKK58_RS16160	COG1842	Phage shock protein A
HKK58_RS16175	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKK58_RS16215	COG1722	exodeoxyribonuclease VII activity
HKK58_RS16220	COG0142	geranyltranstransferase activity
HKK58_RS16225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKK58_RS16230	COG4206	TonB-dependent receptor
HKK58_RS16240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKK58_RS16250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKK58_RS16260	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HKK58_RS16265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKK58_RS16270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HKK58_RS16285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKK58_RS16285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKK58_RS16290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKK58_RS16300	COG2264	protein methyltransferase activity
HKK58_RS16305	COG3118	belongs to the thioredoxin family
HKK58_RS16345	COG1201	RNA secondary structure unwinding
HKK58_RS16350	COG0668	transmembrane transport
HKK58_RS16355	COG2814	Major facilitator Superfamily
HKK58_RS16365	COG3568	Endonuclease Exonuclease Phosphatase
HKK58_RS16370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK58_RS16375	COG0392	lysyltransferase activity
HKK58_RS16390	COG1335	isochorismatase
HKK58_RS16395	COG4106	trans-aconitate 2-methyltransferase activity
HKK58_RS16400	COG0583	DNA-binding transcription factor activity
HKK58_RS16405	COG0629	single-stranded DNA binding
HKK58_RS16410	COG2814	Major facilitator Superfamily
HKK58_RS16415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKK58_RS16420	COG2193	ferroxidase activity
HKK58_RS16430	COG0203	ribosomal protein L17
HKK58_RS16435	COG0202	RNA polymerase activity
HKK58_RS16440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKK58_RS16445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKK58_RS16450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKK58_RS16455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKK58_RS16465	COG0200	Binds to the 23S rRNA
HKK58_RS16470	COG1841	ribosomal large subunit assembly
HKK58_RS16475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKK58_RS16480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKK58_RS16485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKK58_RS16490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKK58_RS16495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKK58_RS16500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKK58_RS16505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKK58_RS16510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKK58_RS16515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKK58_RS16520	COG0255	Belongs to the universal ribosomal protein uL29 family
HKK58_RS16525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKK58_RS16530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKK58_RS16535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKK58_RS16540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKK58_RS16545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKK58_RS16550	COG0089	rRNA binding
HKK58_RS16555	COG0088	Forms part of the polypeptide exit tunnel
HKK58_RS16560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKK58_RS16565	COG0051	transcription antitermination factor activity, RNA binding
HKK58_RS16570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKK58_RS16575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKK58_RS16580	COG0049	tRNA binding
HKK58_RS16585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKK58_RS16590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKK58_RS16595	COG0085	RNA polymerase activity
HKK58_RS16600	COG0222	ribosome binding
HKK58_RS16605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HKK58_RS16610	COG0081	regulation of translation
HKK58_RS16615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKK58_RS16655	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HKK58_RS16690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKK58_RS16695	COG0739	heme binding
HKK58_RS16700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HKK58_RS16705	COG0316	Belongs to the HesB IscA family
HKK58_RS16710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKK58_RS16730	COG4221	oxidoreductase activity
HKK58_RS16735	COG0537	adenosine 5'-monophosphoramidase activity
HKK58_RS16740	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HKK58_RS16745	COG1765	OsmC-like protein
HKK58_RS16760	COG0134	indole-3-glycerol-phosphate synthase activity
HKK58_RS16765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKK58_RS16770	COG0512	Glutamine amidotransferase of anthranilate synthase
HKK58_RS16775	COG4625	pathogenesis
HKK58_RS16775	COG3240	lipase activity
HKK58_RS16780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKK58_RS16785	COG0546	phosphoglycolate phosphatase activity
HKK58_RS16790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKK58_RS16795	COG1454	alcohol dehydrogenase
HKK58_RS16805	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK58_RS16815	COG3842	ATPase activity
HKK58_RS16820	COG2197	response regulator
HKK58_RS16835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HKK58_RS16840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKK58_RS16845	COG3178	'Phosphotransferase
HKK58_RS16850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HKK58_RS16855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKK58_RS16860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HKK58_RS16865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKK58_RS16870	COG2967	ApaG domain
HKK58_RS16875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKK58_RS16880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK58_RS16885	COG2766	serine protein kinase
HKK58_RS16890	COG2718	Belongs to the UPF0229 family
HKK58_RS16895	COG2719	SpoVR family
HKK58_RS16900	COG0617	tRNA 3'-terminal CCA addition
HKK58_RS16910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKK58_RS16915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HKK58_RS16920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKK58_RS16925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HKK58_RS16930	COG0358	DNA primase activity
HKK58_RS16935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKK58_RS16965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK58_RS16970	COG1025	Belongs to the peptidase M16 family
HKK58_RS16980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK58_RS16985	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HKK58_RS16995	COG0535	radical SAM domain protein
HKK58_RS17005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK58_RS17010	COG0583	DNA-binding transcription factor activity
HKK58_RS17015	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS17020	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS17025	COG3706	GGDEF domain
HKK58_RS17035	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS17055	COG2226	methyltransferase
HKK58_RS17055	COG1073	alpha beta
HKK58_RS17060	COG0156	8-amino-7-oxononanoate synthase activity
HKK58_RS17065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HKK58_RS17075	COG2005	Transcriptional regulator
HKK58_RS17075	COG3585	molybdate ion transport
HKK58_RS17085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKK58_RS17100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HKK58_RS17110	COG4566	intracellular signal transduction
HKK58_RS17110	COG0745	RESPONSE REGULATOR receiver
HKK58_RS17120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK58_RS17125	COG1595	DNA-templated transcription, initiation
HKK58_RS17135	COG3321	synthase
HKK58_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS17135	COG0604	alcohol dehydrogenase
HKK58_RS17140	COG4774	siderophore transport
HKK58_RS17155	COG0625	glutathione transferase activity
HKK58_RS17160	COG4452	Inner membrane protein CreD
HKK58_RS17165	COG2205	protein histidine kinase activity
HKK58_RS17170	COG0745	RESPONSE REGULATOR receiver
HKK58_RS17175	COG0189	ligase activity
HKK58_RS17175	COG4067	protein conserved in archaea
HKK58_RS17180	COG0204	Acyl-transferase
HKK58_RS17190	COG1595	DNA-templated transcription, initiation
HKK58_RS17200	COG1063	alcohol dehydrogenase
HKK58_RS17230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKK58_RS17245	COG1017	nitric oxide dioxygenase activity
HKK58_RS17245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK58_RS17250	COG4638	Rieske (2fe-2S)
HKK58_RS17260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HKK58_RS17265	COG0247	lactate metabolic process
HKK58_RS17265	COG2181	nitrate reductase activity
HKK58_RS17270	COG1902	pentaerythritol trinitrate reductase activity
HKK58_RS17270	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK58_RS17315	COG3246	L-lysine catabolic process to acetate
HKK58_RS17320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK58_RS17345	COG1760	l-serine dehydratase
HKK58_RS17360	COG4175	Glycine betaine
HKK58_RS17365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKK58_RS17370	COG1309	transcriptional regulator
HKK58_RS17375	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS17380	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HKK58_RS17400	COG0477	Major facilitator Superfamily
HKK58_RS17405	COG0513	Belongs to the DEAD box helicase family
HKK58_RS17410	COG2081	HI0933 family
HKK58_RS17415	COG1289	transmembrane transporter activity
HKK58_RS17425	COG2153	protein acetylation
HKK58_RS17435	COG1451	nucleotide metabolic process
HKK58_RS17465	COG0126	phosphoglycerate kinase activity
HKK58_RS17470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HKK58_RS17475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKK58_RS17480	COG0640	Transcriptional regulator
HKK58_RS17485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKK58_RS17490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKK58_RS17495	COG1422	Protein of unknown function (DUF1090)
HKK58_RS17525	COG2116	formate transmembrane transporter activity
HKK58_RS17535	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HKK58_RS17540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKK58_RS17550	COG0513	Belongs to the DEAD box helicase family
HKK58_RS17555	COG2353	YceI-like domain
HKK58_RS17560	COG3038	cytochrome b561
HKK58_RS17570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKK58_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS17590	COG1272	protein, Hemolysin III
HKK58_RS17620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKK58_RS17640	COG3052	prosthetic group binding
HKK58_RS17645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HKK58_RS17685	COG2198	Histidine kinase
HKK58_RS17685	COG0784	Response regulator, receiver
HKK58_RS17685	COG0643	Histidine kinase
HKK58_RS17710	COG0189	ligase activity
HKK58_RS17720	COG1678	Uncharacterized ACR, COG1678
HKK58_RS17725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKK58_RS17730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKK58_RS17735	COG0540	Belongs to the ATCase OTCase family
HKK58_RS17740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK58_RS17750	COG0791	NLP P60 protein
HKK58_RS17775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK58_RS17780	COG2813	Specifically methylates the guanine in position
HKK58_RS17780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK58_RS17790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKK58_RS17795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKK58_RS17805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKK58_RS17810	COG2022	thiamine diphosphate biosynthetic process
HKK58_RS17820	COG2363	Small membrane protein
HKK58_RS17825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK58_RS17835	COG2177	Part of the ABC transporter FtsEX involved in
HKK58_RS17840	COG2884	Cell division ATP-binding protein ftsE
HKK58_RS17845	COG0552	protein localization to endoplasmic reticulum
HKK58_RS17850	COG0612	Peptidase, M16
HKK58_RS17855	COG0612	Peptidase, M16
HKK58_RS17860	COG0742	ribosomal rna small subunit methyltransferase
HKK58_RS17865	COG0429	hydrolase of the alpha beta-hydrolase fold
HKK58_RS17875	COG1309	transcriptional regulator
HKK58_RS17890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HKK58_RS17895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKK58_RS17900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKK58_RS17905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKK58_RS17915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK58_RS17920	COG2814	Major facilitator Superfamily
HKK58_RS17925	COG0129	dihydroxy-acid dehydratase activity
HKK58_RS17950	COG1160	GTP binding
HKK58_RS17965	COG1840	ABC-type Fe3 transport system, periplasmic component
HKK58_RS17970	COG1178	ABC-type Fe3 transport system permease component
HKK58_RS17975	COG3842	ATPase activity
HKK58_RS17980	COG0583	DNA-binding transcription factor activity
HKK58_RS17990	COG0789	Transcriptional regulator
HKK58_RS17995	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HKK58_RS18000	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKK58_RS18015	COG0494	nUDIX hydrolase
HKK58_RS18030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKK58_RS18035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HKK58_RS18040	COG2234	aminopeptidase activity
HKK58_RS18045	COG3204	pilus organization
HKK58_RS18050	COG3204	pilus organization
HKK58_RS18055	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK58_RS18060	COG0277	FAD linked oxidase domain protein
HKK58_RS18065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK58_RS18080	COG1683	Conserved Protein
HKK58_RS18145	COG1917	Cupin 2, conserved barrel domain protein
HKK58_RS18145	COG4977	sequence-specific DNA binding
HKK58_RS18150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK58_RS18165	COG1177	transmembrane transport
HKK58_RS18170	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK58_RS18175	COG3842	ATPase activity
HKK58_RS18195	COG0174	glutamine synthetase
HKK58_RS18200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HKK58_RS18205	COG0174	glutamine synthetase
HKK58_RS18220	COG1116	anion transmembrane transporter activity
HKK58_RS18225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK58_RS18230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS18235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS18240	COG0431	NADPH-dependent FMN reductase
HKK58_RS18245	COG0450	alkyl hydroperoxide reductase
HKK58_RS18255	COG4521	taurine ABC transporter
HKK58_RS18260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HKK58_RS18260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKK58_RS18275	COG1522	sequence-specific DNA binding
HKK58_RS18290	COG0330	HflC and HflK could
HKK58_RS18310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HKK58_RS18315	COG0509	glycine decarboxylation via glycine cleavage system
HKK58_RS18320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK58_RS18325	COG1178	ABC-type Fe3 transport system permease component
HKK58_RS18335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK58_RS18345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKK58_RS18350	COG0006	proline dipeptidase activity
HKK58_RS18355	COG3079	Belongs to the UPF0149 family
HKK58_RS18375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKK58_RS18390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS18395	COG1129	ABC transporter
HKK58_RS18395	COG0842	Transport permease protein
HKK58_RS18400	COG0842	Transport permease protein
HKK58_RS18415	COG2271	Major facilitator Superfamily
HKK58_RS18440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HKK58_RS18460	COG2186	Transcriptional regulator
HKK58_RS18465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS18470	COG0765	amino acid transport
HKK58_RS18480	COG1126	abc transporter atp-binding protein
HKK58_RS18490	COG3188	usher protein
HKK58_RS18495	COG3121	Chaperone
HKK58_RS18505	COG0248	Ppx GppA phosphatase
HKK58_RS18510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HKK58_RS18520	COG0586	Pfam SNARE associated Golgi protein
HKK58_RS18530	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HKK58_RS18535	COG1671	Belongs to the UPF0178 family
HKK58_RS18540	COG0672	)-iron permease
HKK58_RS18565	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS18575	COG0488	(ABC) transporter
HKK58_RS18600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HKK58_RS18620	COG0181	hydroxymethylbilane synthase activity
HKK58_RS18630	COG0165	Argininosuccinate lyase
HKK58_RS18635	COG0625	glutathione transferase activity
HKK58_RS18655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK58_RS18665	COG1965	Belongs to the frataxin family
HKK58_RS18675	COG0019	diaminopimelate decarboxylase activity
HKK58_RS18680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKK58_RS18690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKK58_RS18695	COG1011	Hydrolase
HKK58_RS18705	COG0432	Pfam Uncharacterised protein family UPF0047
HKK58_RS18710	COG0004	ammonium transporteR
HKK58_RS18715	COG0347	Belongs to the P(II) protein family
HKK58_RS18725	COG0606	chelatase, subunit chli
HKK58_RS18740	COG0840	transmembrane signaling receptor activity
HKK58_RS18745	COG0583	DNA-binding transcription factor activity
HKK58_RS18750	COG0534	Mate efflux family protein
HKK58_RS18765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKK58_RS18770	COG0427	acetyl-CoA hydrolase
HKK58_RS18785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKK58_RS18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS18810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS18820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS18825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK58_RS18835	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS18845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKK58_RS18850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HKK58_RS18855	COG0747	negative chemotaxis
HKK58_RS18860	COG2003	Belongs to the UPF0758 family
HKK58_RS18865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKK58_RS18870	COG0756	dUTP diphosphatase activity
HKK58_RS18875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK58_RS18880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKK58_RS18885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKK58_RS18890	COG0708	Exodeoxyribonuclease III
HKK58_RS18900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HKK58_RS18905	COG1561	YicC-like family, N-terminal region
HKK58_RS18910	COG0194	GDP metabolic process
HKK58_RS18915	COG1758	RNA polymerase activity
HKK58_RS18920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKK58_RS18950	COG0848	biopolymer transport protein
HKK58_RS18960	COG0583	DNA-binding transcription factor activity
HKK58_RS18965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKK58_RS18995	COG1136	(ABC) transporter
HKK58_RS19000	COG2815	serine threonine protein kinase
HKK58_RS19000	COG0515	serine threonine protein kinase
HKK58_RS19005	COG0631	protein serine/threonine phosphatase activity
HKK58_RS19080	COG3501	Rhs element vgr protein
HKK58_RS19105	COG3209	COG3209 Rhs family protein
HKK58_RS19130	COG3161	chorismate lyase activity
HKK58_RS19135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HKK58_RS19155	COG1253	flavin adenine dinucleotide binding
HKK58_RS19165	COG0704	Plays a role in the regulation of phosphate uptake
HKK58_RS19170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK58_RS19175	COG0573	inorganic phosphate transmembrane transporter activity
HKK58_RS19190	COG0477	Major facilitator Superfamily
HKK58_RS19195	COG1607	acyl-coa hydrolase
HKK58_RS19200	COG0676	glucose-6-phosphate 1-epimerase activity
HKK58_RS19225	COG0583	DNA-binding transcription factor activity
HKK58_RS19230	COG1027	Aspartate ammonia-lyase
HKK58_RS19235	COG1115	amino acid carrier protein
HKK58_RS19240	COG0252	asparaginase activity
HKK58_RS19270	COG2808	Putative FMN-binding domain
HKK58_RS19295	COG5016	pyruvate
HKK58_RS19295	COG0511	ligase activity, forming carbon-carbon bonds
HKK58_RS19300	COG0439	Biotin carboxylase
HKK58_RS19305	COG0583	DNA-binding transcription factor activity
HKK58_RS19320	COG3300	MHYT domain
HKK58_RS19320	COG5001	Diguanylate cyclase
HKK58_RS19340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKK58_RS19340	COG4651	solute:proton antiporter activity
HKK58_RS19345	COG1607	acyl-coa hydrolase
HKK58_RS19350	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HKK58_RS19360	COG0523	cobalamin synthesis protein
HKK58_RS19385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKK58_RS19390	COG1469	GTP cyclohydrolase I activity
HKK58_RS19410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKK58_RS19420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK58_RS19430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK58_RS19435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HKK58_RS19475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKK58_RS19480	COG2267	carboxylic ester hydrolase activity
HKK58_RS19485	COG0671	phosphoesterase, PA-phosphatase related
HKK58_RS19485	COG2453	phosphatase
HKK58_RS19500	COG4589	Belongs to the CDS family
HKK58_RS19505	COG1522	sequence-specific DNA binding
HKK58_RS19510	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS19515	COG2373	Large extracellular alpha-helical protein
HKK58_RS19520	COG4953	penicillin-binding protein 1C
HKK58_RS19535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK58_RS19545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKK58_RS19550	COG1349	DNA-binding transcription factor activity
HKK58_RS19555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK58_RS19560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HKK58_RS19565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKK58_RS19570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKK58_RS19575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKK58_RS19580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKK58_RS19585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HKK58_RS19595	COG0356	it plays a direct role in the translocation of protons across the membrane
HKK58_RS19600	COG3312	ion transport
HKK58_RS19605	COG1475	DNA binding
HKK58_RS19610	COG1192	Involved in chromosome partitioning
HKK58_RS19615	COG0357	Ribosomal RNA small subunit methyltransferase G
HKK58_RS19620	COG0445	tRNA wobble uridine modification
HKK58_RS19625	COG1595	DNA-templated transcription, initiation
HKK58_RS19630	COG3712	iron ion homeostasis
HKK58_RS19635	COG4774	siderophore transport
HKK58_RS19640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HKK58_RS19645	COG0706	membrane insertase activity
HKK58_RS19650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HKK58_RS19655	COG0594	ribonuclease P activity
HKK58_RS19660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HKK58_RS19665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKK58_RS19670	COG0592	DNA-directed DNA polymerase activity
HKK58_RS19680	COG0187	DNA topoisomerase II activity
HKK58_RS19685	COG0745	RESPONSE REGULATOR receiver
HKK58_RS19690	COG5002	protein histidine kinase activity
HKK58_RS19700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HKK58_RS19705	COG0751	glycine-tRNA ligase activity
HKK58_RS19710	COG0752	glycyl-tRNA synthetase alpha subunit
HKK58_RS19715	COG2818	Glycosylase
HKK58_RS19730	COG0569	domain protein
HKK58_RS19735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKK58_RS19740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK58_RS19745	COG0242	peptide deformylase activity
HKK58_RS19755	COG0758	DNA mediated transformation
HKK58_RS19760	COG0009	L-threonylcarbamoyladenylate synthase
HKK58_RS19770	COG0408	coproporphyrinogen oxidase activity
HKK58_RS19775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK58_RS19790	COG3119	arylsulfatase activity
HKK58_RS19795	COG0583	DNA-binding transcription factor activity
HKK58_RS19805	COG3734	2-keto-3-deoxy-galactonokinase
HKK58_RS19810	COG0800	Aldolase
HKK58_RS19815	COG4948	Mandelate Racemase Muconate Lactonizing
HKK58_RS19820	COG2271	Major facilitator Superfamily
HKK58_RS19830	COG0159	tryptophan synthase activity
HKK58_RS19850	COG3360	Dodecin
HKK58_RS19860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS19865	COG1764	response to oxidative stress
HKK58_RS19890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKK58_RS19895	COG0339	signal peptide processing
HKK58_RS19935	COG0659	secondary active sulfate transmembrane transporter activity
HKK58_RS19945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKK58_RS19950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKK58_RS19955	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HKK58_RS19980	COG1612	heme a metabolic process
HKK58_RS19985	COG0109	protoheme IX farnesyltransferase activity
HKK58_RS20000	COG2011	ABC-type metal ion transport system permease component
HKK58_RS20005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK58_RS20020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK58_RS20025	COG1121	(ABC) transporter
HKK58_RS20030	COG0735	belongs to the Fur family
HKK58_RS20035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HKK58_RS20055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HKK58_RS20070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKK58_RS20085	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKK58_RS20090	COG5002	protein histidine kinase activity
HKK58_RS20095	COG2204	response regulator
HKK58_RS20105	COG5487	UPF0391 membrane protein
HKK58_RS20115	COG1301	dicarboxylic acid transport
HKK58_RS20120	COG0700	Nucleoside recognition
HKK58_RS20135	COG1127	ABC transporter
HKK58_RS20140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKK58_RS20150	COG0612	Peptidase, M16
HKK58_RS20155	COG1283	sodium-dependent phosphate transmembrane transporter activity
HKK58_RS20160	COG0861	Integral membrane protein TerC family
HKK58_RS20165	COG2851	Citrate transporter
HKK58_RS20200	COG0427	acetyl-CoA hydrolase
HKK58_RS20220	COG0583	DNA-binding transcription factor activity
HKK58_RS20225	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS20270	COG3712	iron ion homeostasis
HKK58_RS20275	COG1595	DNA-templated transcription, initiation
HKK58_RS20280	COG0840	transmembrane signaling receptor activity
HKK58_RS20315	COG5001	Diguanylate cyclase
HKK58_RS20315	COG3300	MHYT domain
HKK58_RS20330	COG1538	Outer membrane efflux protein
HKK58_RS20335	COG2274	protein secretion by the type I secretion system
HKK58_RS20340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS20345	COG2175	clavaminate synthase activity
HKK58_RS20355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK58_RS20410	COG1289	transmembrane transporter activity
HKK58_RS20420	COG1566	PFAM secretion protein HlyD family protein
HKK58_RS20435	COG5339	Protein conserved in bacteria
HKK58_RS20440	COG0457	Tetratricopeptide repeat
HKK58_RS20445	COG0726	polysaccharide deacetylase
HKK58_RS20445	COG1649	PFAM Uncharacterised BCR, COG1649
HKK58_RS20450	COG1215	transferase activity, transferring glycosyl groups
HKK58_RS20570	COG2304	oxidoreductase activity
HKK58_RS20575	COG1595	DNA-templated transcription, initiation
HKK58_RS20595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HKK58_RS20640	COG1715	Restriction endonuclease
HKK58_RS20660	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS20665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK58_RS20670	COG0745	RESPONSE REGULATOR receiver
HKK58_RS20695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKK58_RS20705	COG4208	sulfate ABC transporter
HKK58_RS20710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HKK58_RS20720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK58_RS20750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK58_RS20755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK58_RS20780	COG4771	TonB-dependent receptor
HKK58_RS20785	COG2807	transmembrane transport
HKK58_RS20790	COG0583	DNA-binding transcription factor activity
HKK58_RS20825	COG0765	amino acid transport
HKK58_RS20830	COG0765	amino acid transport
HKK58_RS20835	COG1126	abc transporter atp-binding protein
HKK58_RS20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS20860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK58_RS20875	COG2011	ABC-type metal ion transport system permease component
HKK58_RS20880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK58_RS20885	COG1464	Belongs to the NlpA lipoprotein family
HKK58_RS20925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HKK58_RS20930	COG1045	serine acetyltransferase
HKK58_RS20935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKK58_RS20945	COG0667	Aldo Keto reductase
HKK58_RS20955	COG2175	clavaminate synthase activity
HKK58_RS20960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK58_RS20965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HKK58_RS20970	COG4521	taurine ABC transporter
HKK58_RS20975	COG2918	glutathione biosynthetic process
HKK58_RS20985	COG2183	response to ionizing radiation
HKK58_RS20990	COG0745	RESPONSE REGULATOR receiver
HKK58_RS21000	COG0189	ligase activity
HKK58_RS21005	COG4067	protein conserved in archaea
HKK58_RS21005	COG0189	ligase activity
HKK58_RS21010	COG2200	EAL domain
HKK58_RS21015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKK58_RS21025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HKK58_RS21030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HKK58_RS21055	COG0514	ATP-dependent DNA helicase (RecQ)
HKK58_RS21060	COG0824	Thioesterase
HKK58_RS21070	COG0243	molybdopterin cofactor binding
HKK58_RS21085	COG1652	LysM domain
HKK58_RS21090	COG1011	Hydrolase
HKK58_RS21095	COG0494	nUDIX hydrolase
HKK58_RS21100	COG1218	3'(2'),5'-bisphosphate nucleotidase
HKK58_RS21125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK58_RS21130	COG2957	Belongs to the agmatine deiminase family
HKK58_RS21155	COG1942	4-Oxalocrotonate Tautomerase
HKK58_RS21165	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS21185	COG1192	Involved in chromosome partitioning
HKK58_RS21205	COG4215	(ABC) transporter
HKK58_RS21250	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HKK58_RS21255	COG1194	a g-specific adenine glycosylase
HKK58_RS21265	COG2223	nitrite transmembrane transporter activity
HKK58_RS21280	COG0131	Imidazoleglycerol-phosphate dehydratase
HKK58_RS21285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKK58_RS21295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKK58_RS21300	COG0107	imidazoleglycerol-phosphate synthase activity
HKK58_RS21310	COG2861	carbohydrate metabolic process
HKK58_RS21315	COG0793	Belongs to the peptidase S41A family
HKK58_RS21320	COG4942	peptidase
HKK58_RS21325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKK58_RS21330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK58_RS21340	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HKK58_RS21360	COG3852	Histidine kinase
HKK58_RS21385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK58_RS21385	COG0301	tRNA thio-modification
HKK58_RS21400	COG0058	SHG alpha-glucan phosphorylase activity
HKK58_RS21415	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HKK58_RS21430	COG0402	S-adenosylhomocysteine deaminase activity
HKK58_RS21435	COG2188	Transcriptional regulator
HKK58_RS21445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HKK58_RS21450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKK58_RS21460	COG4176	ABC-type proline glycine betaine transport system permease component
HKK58_RS21465	COG4175	Glycine betaine
HKK58_RS21465	COG0517	IMP dehydrogenase activity
HKK58_RS21470	COG2986	histidine ammonia-lyase
HKK58_RS21475	COG2986	histidine ammonia-lyase
HKK58_RS21485	COG1228	amidohydrolase
HKK58_RS21505	COG0596	Alpha beta hydrolase
HKK58_RS21510	COG1490	D-aminoacyl-tRNA deacylase activity
HKK58_RS21515	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HKK58_RS21520	COG2943	transferase activity, transferring hexosyl groups
HKK58_RS21525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS21530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS21535	COG0765	amino acid transport
HKK58_RS21540	COG1126	abc transporter atp-binding protein
HKK58_RS21545	COG0840	transmembrane signaling receptor activity
HKK58_RS21560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKK58_RS21565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKK58_RS21570	COG0140	phosphoribosyl-ATP diphosphatase activity
HKK58_RS21575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKK58_RS21580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKK58_RS21590	COG2226	methyltransferase
HKK58_RS21635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HKK58_RS21640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HKK58_RS21650	COG0018	arginyl-trna synthetase
HKK58_RS21655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKK58_RS21660	COG0254	rRNA binding
HKK58_RS21665	COG0281	malic enzyme
HKK58_RS21695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKK58_RS21700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKK58_RS21710	COG0067	glutamate synthase
HKK58_RS21710	COG0070	glutamate synthase
HKK58_RS21710	COG0069	glutamate synthase activity
HKK58_RS21715	COG0493	'glutamate synthase
HKK58_RS21720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HKK58_RS21725	COG2814	Major facilitator Superfamily
HKK58_RS21730	COG0583	DNA-binding transcription factor activity
HKK58_RS21745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK58_RS21750	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS21760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK58_RS21770	COG2226	methyltransferase
HKK58_RS21795	COG2986	histidine ammonia-lyase
HKK58_RS21810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKK58_RS21820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK58_RS21825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK58_RS21840	COG1192	Involved in chromosome partitioning
HKK58_RS21850	COG3118	belongs to the thioredoxin family
HKK58_RS21855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HKK58_RS21860	COG3264	Mechanosensitive ion channel
HKK58_RS21860	COG1196	nuclear chromosome segregation
HKK58_RS21865	COG3263	regulation of cellular component size
HKK58_RS21885	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS21890	COG0506	proline dehydrogenase activity
HKK58_RS21890	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKK58_RS21890	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKK58_RS21900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK58_RS21920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HKK58_RS21925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK58_RS21945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKK58_RS21950	COG0859	PFAM glycosyl transferase family 9
HKK58_RS21955	COG0859	PFAM glycosyl transferase family 9
HKK58_RS21960	COG0438	transferase activity, transferring glycosyl groups
HKK58_RS21970	COG3642	lipopolysaccharide core region biosynthetic process
HKK58_RS21985	COG4772	TonB-dependent receptor
HKK58_RS22000	COG2192	nodulation
HKK58_RS22005	COG0438	transferase activity, transferring glycosyl groups
HKK58_RS22030	COG1215	transferase activity, transferring glycosyl groups
HKK58_RS22040	COG1132	(ABC) transporter
HKK58_RS22045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HKK58_RS22045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HKK58_RS22050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK58_RS22060	COG0667	Aldo Keto reductase
HKK58_RS22080	COG1519	Transferase
HKK58_RS22085	COG1538	Outer membrane efflux protein
HKK58_RS22090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HKK58_RS22105	COG0494	nUDIX hydrolase
HKK58_RS22115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKK58_RS22120	COG3150	esterase
HKK58_RS22155	COG0560	Phosphoserine phosphatase
HKK58_RS22155	COG3830	Belongs to the UPF0237 family
HKK58_RS22160	COG0688	phosphatidylethanolamine metabolic process
HKK58_RS22185	COG1162	GTPase activity
HKK58_RS22190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HKK58_RS22195	COG2860	membrane
HKK58_RS22205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKK58_RS22205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKK58_RS22210	COG0802	atpase or kinase
HKK58_RS22215	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKK58_RS22220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKK58_RS22225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKK58_RS22230	COG1923	regulation of RNA biosynthetic process
HKK58_RS22235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKK58_RS22240	COG0330	HflC and HflK could
HKK58_RS22245	COG0330	HflC and HflK could
HKK58_RS22250	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HKK58_RS22255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKK58_RS22265	COG1178	ABC-type Fe3 transport system permease component
HKK58_RS22270	COG1840	ABC-type Fe3 transport system, periplasmic component
HKK58_RS22285	COG0557	exoribonuclease II activity
HKK58_RS22290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKK58_RS22295	COG0360	Binds together with S18 to 16S ribosomal RNA
HKK58_RS22300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKK58_RS22310	COG0359	binds to the 23S rRNA
HKK58_RS22315	COG0305	Participates in initiation and elongation during chromosome replication
HKK58_RS22320	COG1032	radical SAM domain protein
HKK58_RS22340	COG2308	Evidence 4 Homologs of previously reported genes of
HKK58_RS22340	COG2307	Protein conserved in bacteria
HKK58_RS22360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKK58_RS22365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKK58_RS22370	COG0583	DNA-binding transcription factor activity
HKK58_RS22375	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS22380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS22410	COG4221	oxidoreductase activity
HKK58_RS22430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKK58_RS22435	COG0830	nickel cation binding
HKK58_RS22440	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HKK58_RS22445	COG0791	NLP P60 protein
HKK58_RS22450	COG1309	transcriptional regulator
HKK58_RS22460	COG2982	Protein involved in outer membrane biogenesis
HKK58_RS22470	COG0583	DNA-binding transcription factor activity
HKK58_RS22475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKK58_RS22480	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HKK58_RS22485	COG0697	spore germination
HKK58_RS22515	COG0443	Heat shock 70 kDa protein
HKK58_RS22520	COG0484	heat shock protein binding
HKK58_RS22530	COG0804	urea catabolic process
HKK58_RS22535	COG0832	Belongs to the urease beta subunit family
HKK58_RS22550	COG0831	urea catabolic process
HKK58_RS22555	COG0829	nickel cation binding
HKK58_RS22565	COG0411	ABC transporter
HKK58_RS22590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK58_RS22600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HKK58_RS22605	COG4774	siderophore transport
HKK58_RS22650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK58_RS22675	COG2095	MarC family integral membrane protein
HKK58_RS22685	COG0151	Belongs to the GarS family
HKK58_RS22690	COG0138	bifunctional purine biosynthesis protein purh
HKK58_RS22700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKK58_RS22710	COG2264	protein methyltransferase activity
HKK58_RS22725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HKK58_RS22750	COG0023	Translation Initiation Factor
HKK58_RS22755	COG1166	arginine decarboxylase activity
HKK58_RS22765	COG0534	Mate efflux family protein
HKK58_RS22770	COG2373	Large extracellular alpha-helical protein
HKK58_RS22780	COG4953	penicillin-binding protein 1C
HKK58_RS22790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKK58_RS22860	COG4964	Belongs to the GSP D family
HKK58_RS22905	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS22925	COG2217	Heavy metal translocating P-type atpase
HKK58_RS22940	COG2814	Major facilitator Superfamily
HKK58_RS22950	COG0604	alcohol dehydrogenase
HKK58_RS22955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HKK58_RS22960	COG0583	DNA-binding transcription factor activity
HKK58_RS22970	COG0477	Major facilitator Superfamily
HKK58_RS22975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKK58_RS22980	COG0387	Pfam Sodium calcium exchanger
HKK58_RS23010	COG1309	transcriptional regulator
HKK58_RS23015	COG2233	PERMEase
HKK58_RS23060	COG2995	paraquat-inducible protein a
HKK58_RS23065	COG2995	paraquat-inducible protein a
HKK58_RS23070	COG3008	intermembrane lipid transfer
HKK58_RS23095	COG0456	acetyltransferase
HKK58_RS23105	COG0288	reversible hydration of carbon dioxide
HKK58_RS23125	COG2031	fatty acid transporter
HKK58_RS23185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKK58_RS23210	COG3655	Transcriptional regulator
HKK58_RS23230	COG0405	Gamma-glutamyltransferase
HKK58_RS23375	COG0582	viral genome integration into host DNA
HKK58_RS23405	COG1157	protein secretion by the type III secretion system
HKK58_RS23430	COG4794	Type iii secretion
HKK58_RS23440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKK58_RS23470	COG4669	(LipO)protein
HKK58_RS23495	COG0193	aminoacyl-tRNA hydrolase activity
HKK58_RS23500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HKK58_RS23505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKK58_RS23515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HKK58_RS23520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HKK58_RS23530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HKK58_RS23535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKK58_RS23550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HKK58_RS23570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HKK58_RS23580	COG0493	'glutamate synthase
HKK58_RS23585	COG4221	oxidoreductase activity
HKK58_RS23595	COG0415	Belongs to the DNA photolyase family
HKK58_RS23600	COG0789	Transcriptional regulator
HKK58_RS23615	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HKK58_RS23620	COG1090	epimerase
HKK58_RS23625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HKK58_RS23640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK58_RS23650	COG0175	sulfate reduction
HKK58_RS23660	COG0204	Acyl-transferase
HKK58_RS23665	COG0280	phosphate acetyltransferase
HKK58_RS23665	COG0857	belongs to the CobB CobQ family
HKK58_RS23680	COG0268	Binds directly to 16S ribosomal RNA
HKK58_RS23690	COG0196	riboflavin kinase activity
HKK58_RS23695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKK58_RS23700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKK58_RS23705	COG1047	Peptidyl-prolyl cis-trans
HKK58_RS23710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HKK58_RS23740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK58_RS23765	COG0542	response to heat
HKK58_RS23790	COG1335	isochorismatase
HKK58_RS23795	COG0583	DNA-binding transcription factor activity
HKK58_RS23800	COG1252	NADH dehydrogenase
HKK58_RS23830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HKK58_RS23835	COG0237	dephospho-CoA kinase activity
HKK58_RS23840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HKK58_RS23875	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKK58_RS23885	COG0840	transmembrane signaling receptor activity
HKK58_RS23895	COG0084	hydrolase, TatD family'
HKK58_RS23900	COG1609	Transcriptional regulator
HKK58_RS23910	COG1105	Belongs to the carbohydrate kinase PfkB family
HKK58_RS23915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HKK58_RS23915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK58_RS23915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK58_RS23925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HKK58_RS23930	COG4774	siderophore transport
HKK58_RS23935	COG3128	pkhd-type hydroxylase
HKK58_RS23945	COG0019	diaminopimelate decarboxylase activity
HKK58_RS23970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKK58_RS23990	COG4608	Belongs to the ABC transporter superfamily
HKK58_RS23995	COG0444	Belongs to the ABC transporter superfamily
HKK58_RS24000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK58_RS24005	COG0601	transmembrane transport
HKK58_RS24010	COG0747	negative chemotaxis
HKK58_RS24020	COG0747	negative chemotaxis
HKK58_RS24025	COG0747	negative chemotaxis
HKK58_RS24030	COG0747	negative chemotaxis
HKK58_RS24045	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HKK58_RS24050	COG4178	(ABC) transporter
HKK58_RS24065	COG0180	Tryptophanyl-tRNA synthetase
HKK58_RS24070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK58_RS24080	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS24085	COG0667	Aldo Keto reductase
HKK58_RS24090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKK58_RS24095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HKK58_RS24100	COG0723	plastoquinol--plastocyanin reductase activity
HKK58_RS24105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HKK58_RS24110	COG2857	Cytochrome c1
HKK58_RS24115	COG0625	glutathione transferase activity
HKK58_RS24120	COG2969	positive regulation of protein catabolic process
HKK58_RS24125	COG2186	Transcriptional regulator
HKK58_RS24135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK58_RS24145	COG2271	Major facilitator Superfamily
HKK58_RS24150	COG2721	sulfolactate sulfo-lyase activity
HKK58_RS24160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK58_RS24170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKK58_RS24175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKK58_RS24180	COG0154	amidase activity
HKK58_RS24185	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKK58_RS24190	COG1077	Cell shape determining protein MreB Mrl
HKK58_RS24195	COG1792	Involved in formation and maintenance of cell shape
HKK58_RS24205	COG0424	maF-like protein
HKK58_RS24210	COG1530	ribonuclease E activity
HKK58_RS24220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK58_RS24225	COG0312	modulator of DNA gyrase
HKK58_RS24230	COG3028	Belongs to the UPF0307 family
HKK58_RS24235	COG0312	modulator of DNA gyrase
HKK58_RS24270	COG1660	Displays ATPase and GTPase activities
HKK58_RS24285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HKK58_RS24290	COG1137	ATPase activity
HKK58_RS24295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HKK58_RS24305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HKK58_RS24315	COG1127	ABC transporter
HKK58_RS24320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKK58_RS24325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKK58_RS24345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKK58_RS24350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HKK58_RS24355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKK58_RS24360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKK58_RS24370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKK58_RS24435	COG2135	peptidase activity
HKK58_RS24440	COG0840	transmembrane signaling receptor activity
HKK58_RS24450	COG2119	membrane
HKK58_RS24455	COG2813	Specifically methylates the guanine in position
HKK58_RS24460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK58_RS24465	COG1280	lysine exporter protein (LysE YggA)
HKK58_RS24470	COG0318	PFAM AMP-dependent synthetase and ligase
HKK58_RS24490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKK58_RS24495	COG2885	chlorophyll binding
HKK58_RS24500	COG2823	Periplasmic or secreted lipoprotein
HKK58_RS24505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HKK58_RS24510	COG0792	nuclease activity
HKK58_RS24530	COG2001	Belongs to the MraZ family
HKK58_RS24535	COG0275	rRNA processing
HKK58_RS24550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKK58_RS24555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKK58_RS24560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKK58_RS24565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKK58_RS24570	COG0772	Belongs to the SEDS family
HKK58_RS24575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKK58_RS24580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKK58_RS24585	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKK58_RS24600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKK58_RS24605	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HKK58_RS24615	COG5001	Diguanylate cyclase
HKK58_RS24615	COG4251	negative regulation of phosphorylation
HKK58_RS24615	COG3706	GGDEF domain
HKK58_RS24615	COG2203	Gaf domain
HKK58_RS24620	COG3706	GGDEF domain
HKK58_RS24620	COG4251	negative regulation of phosphorylation
HKK58_RS24620	COG2203	Gaf domain
HKK58_RS24620	COG5001	Diguanylate cyclase
HKK58_RS24630	COG5002	protein histidine kinase activity
HKK58_RS24655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS24660	COG0840	transmembrane signaling receptor activity
HKK58_RS24665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS24680	COG0835	chemotaxis
HKK58_RS24680	COG0784	Response regulator, receiver
HKK58_RS24685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK58_RS24690	COG0583	DNA-binding transcription factor activity
HKK58_RS24710	COG1566	PFAM secretion protein HlyD family protein
HKK58_RS24720	COG0477	Major facilitator Superfamily
HKK58_RS24730	COG0300	oxidoreductase activity
HKK58_RS24740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HKK58_RS24740	COG0662	Cupin 2, conserved barrel domain protein
HKK58_RS24755	COG1696	Membrane protein involved in D-alanine export
HKK58_RS24770	COG3420	alginic acid biosynthetic process
HKK58_RS24780	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HKK58_RS24785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS24795	COG1215	transferase activity, transferring glycosyl groups
HKK58_RS24805	COG3022	response to hydroperoxide
HKK58_RS24815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HKK58_RS24825	COG0315	cyclic pyranopterin monophosphate synthase activity
HKK58_RS24830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HKK58_RS24840	COG0513	Belongs to the DEAD box helicase family
HKK58_RS24845	COG0400	carboxylic ester hydrolase activity
HKK58_RS24850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS24855	COG4597	amino acid ABC transporter
HKK58_RS24860	COG0765	amino acid transport
HKK58_RS24865	COG1126	abc transporter atp-binding protein
HKK58_RS24880	COG2186	Transcriptional regulator
HKK58_RS24885	COG2807	transmembrane transport
HKK58_RS24890	COG3539	Fimbrial protein
HKK58_RS24900	COG3539	Fimbrial protein
HKK58_RS24905	COG3188	usher protein
HKK58_RS24910	COG3121	Chaperone
HKK58_RS24920	COG3539	Fimbrial protein
HKK58_RS24935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS24935	COG2198	Histidine kinase
HKK58_RS24935	COG2205	protein histidine kinase activity
HKK58_RS24935	COG0784	Response regulator, receiver
HKK58_RS24950	COG2827	Endonuclease containing a URI domain
HKK58_RS24960	COG4774	siderophore transport
HKK58_RS24965	COG2027	D-alanyl-D-alanine carboxypeptidase
HKK58_RS24975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HKK58_RS24980	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK58_RS25000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKK58_RS25020	COG0814	amino acid
HKK58_RS25025	COG1760	l-serine dehydratase
HKK58_RS25030	COG0583	DNA-binding transcription factor activity
HKK58_RS25040	COG0477	Major facilitator Superfamily
HKK58_RS25045	COG0583	DNA-binding transcription factor activity
HKK58_RS25050	COG4772	TonB-dependent receptor
HKK58_RS25055	COG3712	iron ion homeostasis
HKK58_RS25060	COG1595	DNA-templated transcription, initiation
HKK58_RS25095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKK58_RS25100	COG3081	Nucleoid-associated protein
HKK58_RS25110	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HKK58_RS25115	COG0525	valine-tRNA ligase activity
HKK58_RS25130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKK58_RS25135	COG0795	lipopolysaccharide-transporting ATPase activity
HKK58_RS25140	COG0795	lipopolysaccharide-transporting ATPase activity
HKK58_RS25145	COG0481	GTPase activity
HKK58_RS25150	COG0681	Belongs to the peptidase S26 family
HKK58_RS25155	COG0571	ribonuclease III activity
HKK58_RS25160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKK58_RS25165	COG1381	Involved in DNA repair and RecF pathway recombination
HKK58_RS25170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HKK58_RS25180	COG0590	tRNA wobble adenosine to inosine editing
HKK58_RS25185	COG0500	methyltransferase
HKK58_RS25190	COG2226	methyltransferase
HKK58_RS25205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HKK58_RS25245	COG0523	cobalamin synthesis protein
HKK58_RS25265	COG4206	TonB-dependent receptor
HKK58_RS25270	COG4628	conserved protein (DUF2132)
HKK58_RS25280	COG2375	cellular response to nickel ion
HKK58_RS25285	COG1695	Transcriptional regulator
HKK58_RS25330	COG1113	amino acid transport
HKK58_RS25345	COG0069	glutamate synthase activity
HKK58_RS25350	COG2197	response regulator
HKK58_RS25360	COG0531	amino acid
HKK58_RS25365	COG0254	rRNA binding
HKK58_RS25385	COG0583	DNA-binding transcription factor activity
HKK58_RS25410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK58_RS25425	COG4191	Histidine kinase
HKK58_RS25450	COG1126	abc transporter atp-binding protein
HKK58_RS25455	COG0765	amino acid transport
HKK58_RS25460	COG0765	amino acid transport
HKK58_RS25465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS25470	COG4774	siderophore transport
HKK58_RS25490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKK58_RS25500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKK58_RS25505	COG3842	ATPase activity
HKK58_RS25510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKK58_RS25515	COG0243	molybdopterin cofactor binding
HKK58_RS25520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKK58_RS25535	COG0450	alkyl hydroperoxide reductase
HKK58_RS25540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK58_RS25545	COG0418	dihydroorotase activity
HKK58_RS25555	COG0137	argininosuccinate synthase activity
HKK58_RS25560	COG2197	response regulator
HKK58_RS25570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKK58_RS25575	COG2878	Part of a membrane complex involved in electron transport
HKK58_RS25580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK58_RS25580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK58_RS25585	COG0489	protein tyrosine kinase activity
HKK58_RS25590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HKK58_RS25595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HKK58_RS25700	COG3179	chitinase
HKK58_RS25710	COG1546	Belongs to the CinA family
HKK58_RS25715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKK58_RS25720	COG2137	regulation of response to DNA damage stimulus
HKK58_RS25750	COG0583	DNA-binding transcription factor activity
HKK58_RS25765	COG4807	Protein conserved in bacteria
HKK58_RS25780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKK58_RS25785	COG3158	transport of potassium into the cell
HKK58_RS25790	COG1902	pentaerythritol trinitrate reductase activity
HKK58_RS25800	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HKK58_RS25805	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HKK58_RS25810	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS25815	COG1177	transmembrane transport
HKK58_RS25820	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK58_RS25825	COG3842	ATPase activity
HKK58_RS25830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HKK58_RS25840	COG0583	DNA-binding transcription factor activity
HKK58_RS25860	COG0457	Tetratricopeptide repeat
HKK58_RS25860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK58_RS25875	COG2201	protein-glutamate methylesterase activity
HKK58_RS25880	COG5001	Diguanylate cyclase
HKK58_RS25880	COG3706	GGDEF domain
HKK58_RS25880	COG2203	Gaf domain
HKK58_RS25880	COG4251	negative regulation of phosphorylation
HKK58_RS25890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKK58_RS25910	COG1073	alpha beta
HKK58_RS25925	COG2885	chlorophyll binding
HKK58_RS25940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKK58_RS25945	COG0563	adenylate kinase activity
HKK58_RS25950	COG1214	PFAM Peptidase M22, glycoprotease
HKK58_RS25960	COG1801	Protein of unknown function DUF72
HKK58_RS25980	COG0742	ribosomal rna small subunit methyltransferase
HKK58_RS26015	COG2937	Belongs to the GPAT DAPAT family
HKK58_RS26030	COG2226	methyltransferase
HKK58_RS26035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK58_RS26040	COG1215	transferase activity, transferring glycosyl groups
HKK58_RS26045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HKK58_RS26050	COG2166	iron-sulfur cluster assembly
HKK58_RS26055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKK58_RS26060	COG2171	N-acyltransferase activity
HKK58_RS26065	COG1393	Belongs to the ArsC family
HKK58_RS26070	COG0025	NhaP-type Na H and K H
HKK58_RS26075	COG0436	Aminotransferase
HKK58_RS26080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HKK58_RS26085	COG0024	Methionine aminopeptidase
HKK58_RS26090	COG0052	Belongs to the universal ribosomal protein uS2 family
HKK58_RS26095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKK58_RS26100	COG0528	UMP kinase activity
HKK58_RS26105	COG0233	cytoplasmic translational termination
HKK58_RS26110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKK58_RS26120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HKK58_RS26130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKK58_RS26140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK58_RS26145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKK58_RS26150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK58_RS26155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKK58_RS26160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKK58_RS26165	COG0587	DNA-directed DNA polymerase activity
HKK58_RS26170	COG0825	malonyl-CoA metabolic process
HKK58_RS26175	COG0037	tRNA processing
HKK58_RS26180	COG0504	CTP synthase activity
HKK58_RS26185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HKK58_RS26190	COG0148	phosphopyruvate hydratase activity
HKK58_RS26200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HKK58_RS26210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HKK58_RS26215	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HKK58_RS26220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HKK58_RS26225	COG0585	pseudouridine synthase activity
HKK58_RS26230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HKK58_RS26235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKK58_RS26250	COG1278	Cold shock
HKK58_RS26255	COG0717	Belongs to the dCTP deaminase family
HKK58_RS26270	COG1201	RNA secondary structure unwinding
HKK58_RS26285	COG4160	amino acid transport
HKK58_RS26300	COG1793	dna ligase
HKK58_RS26310	COG2366	antibiotic biosynthetic process
HKK58_RS26315	COG0625	glutathione transferase activity
HKK58_RS26320	COG1120	ATPase activity
HKK58_RS26325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK58_RS26335	COG4774	siderophore transport
HKK58_RS26340	COG0745	RESPONSE REGULATOR receiver
HKK58_RS26345	COG2205	protein histidine kinase activity
HKK58_RS26350	COG0653	protein targeting
HKK58_RS26360	COG3012	SEC-C Motif Domain Protein
HKK58_RS26390	COG1199	ATP-dependent helicase activity
HKK58_RS26410	COG0259	pyridoxamine-phosphate oxidase activity
HKK58_RS26425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK58_RS26435	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HKK58_RS26450	COG0583	DNA-binding transcription factor activity
HKK58_RS26465	COG3220	belongs to the UPF0276 family
HKK58_RS26520	COG0727	PFAM Uncharacterised protein family (UPF0153)
HKK58_RS26525	COG2271	Major facilitator Superfamily
HKK58_RS26530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKK58_RS26550	COG0583	DNA-binding transcription factor activity
HKK58_RS26560	COG0306	phosphate transporter
HKK58_RS26580	COG1414	Transcriptional regulator
HKK58_RS26585	COG2814	Major facilitator Superfamily
HKK58_RS26590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKK58_RS26595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKK58_RS26600	COG0183	Belongs to the thiolase family
HKK58_RS26605	COG3485	protocatechuate 3,4-dioxygenase
HKK58_RS26610	COG3485	protocatechuate 3,4-dioxygenase
HKK58_RS26615	COG0477	Major facilitator Superfamily
HKK58_RS26625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK58_RS26630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK58_RS26650	COG0443	Heat shock 70 kDa protein
HKK58_RS26665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS26670	COG1309	transcriptional regulator
HKK58_RS26675	COG1902	pentaerythritol trinitrate reductase activity
HKK58_RS26680	COG2814	Major facilitator Superfamily
HKK58_RS26720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK58_RS26735	COG1704	LemA family
HKK58_RS26755	COG0697	spore germination
HKK58_RS26760	COG1629	transport
HKK58_RS26770	COG1595	DNA-templated transcription, initiation
HKK58_RS26780	COG1454	alcohol dehydrogenase
HKK58_RS26795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK58_RS26800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK58_RS26805	COG2271	Major facilitator Superfamily
HKK58_RS26840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKK58_RS26845	COG0583	DNA-binding transcription factor activity
HKK58_RS26850	COG2814	Major facilitator Superfamily
HKK58_RS26875	COG2267	carboxylic ester hydrolase activity
HKK58_RS26910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKK58_RS26945	COG0642	Histidine kinase
HKK58_RS26960	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HKK58_RS26990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK58_RS27000	COG0425	Belongs to the sulfur carrier protein TusA family
HKK58_RS27005	COG0628	permease
HKK58_RS27010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKK58_RS27020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK58_RS27025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HKK58_RS27030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK58_RS27035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HKK58_RS27075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS27075	COG2205	protein histidine kinase activity
HKK58_RS27080	COG2197	response regulator
HKK58_RS27095	COG1595	DNA-templated transcription, initiation
HKK58_RS27105	COG0583	DNA-binding transcription factor activity
HKK58_RS27110	COG0477	Major facilitator Superfamily
HKK58_RS27130	COG4191	Histidine kinase
HKK58_RS27130	COG0784	Response regulator, receiver
HKK58_RS27135	COG2205	protein histidine kinase activity
HKK58_RS27145	COG2172	sigma factor antagonist activity
HKK58_RS27150	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK58_RS27155	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK58_RS27160	COG0583	DNA-binding transcription factor activity
HKK58_RS27210	COG2807	transmembrane transport
HKK58_RS27215	COG1012	belongs to the aldehyde dehydrogenase family
HKK58_RS27225	COG0583	DNA-binding transcription factor activity
HKK58_RS27230	COG2910	NAD(P)H-binding
HKK58_RS27240	COG0583	DNA-binding transcription factor activity
HKK58_RS27275	COG0174	glutamine synthetase
HKK58_RS27290	COG3100	YcgL domain-containing protein
HKK58_RS27295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK58_RS27305	COG2983	Belongs to the UPF0260 family
HKK58_RS27350	COG1770	oligopeptidase
HKK58_RS27360	COG0121	glutamine amidotransferase
HKK58_RS27370	COG0583	DNA-binding transcription factor activity
HKK58_RS27375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HKK58_RS27380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HKK58_RS27385	COG1984	allophanate hydrolase subunit 2
HKK58_RS27395	COG0542	response to heat
HKK58_RS27410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKK58_RS27425	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HKK58_RS27430	COG0425	Belongs to the sulfur carrier protein TusA family
HKK58_RS27440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK58_RS27450	COG1132	(ABC) transporter
HKK58_RS27455	COG0741	lytic transglycosylase activity
HKK58_RS27465	COG0589	response to stress
HKK58_RS27475	COG1024	Enoyl-CoA hydratase
HKK58_RS27475	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK58_RS27480	COG0183	Belongs to the thiolase family
HKK58_RS27525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKK58_RS27535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKK58_RS27555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK58_RS27560	COG0584	glycerophosphoryl diester phosphodiesterase
HKK58_RS27570	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKK58_RS27575	COG1136	(ABC) transporter
HKK58_RS27580	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKK58_RS27600	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HKK58_RS27600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HKK58_RS27615	COG2853	Lipoprotein
HKK58_RS27625	COG2204	response regulator
HKK58_RS27635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKK58_RS27665	COG2814	Major facilitator Superfamily
HKK58_RS27670	COG0579	oxidoreductase
HKK58_RS27680	COG0583	DNA-binding transcription factor activity
HKK58_RS27685	COG0583	DNA-binding transcription factor activity
HKK58_RS27720	COG1611	Belongs to the LOG family
HKK58_RS27730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HKK58_RS27740	COG0583	DNA-binding transcription factor activity
HKK58_RS27745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK58_RS27750	COG0583	DNA-binding transcription factor activity
HKK58_RS27755	COG2814	Major facilitator Superfamily
HKK58_RS27765	COG2233	PERMEase
HKK58_RS27770	COG2267	carboxylic ester hydrolase activity
HKK58_RS27775	COG2197	response regulator
HKK58_RS27780	COG0596	Alpha beta hydrolase
HKK58_RS27795	COG0444	Belongs to the ABC transporter superfamily
HKK58_RS27800	COG4608	Belongs to the ABC transporter superfamily
HKK58_RS27805	COG0747	negative chemotaxis
HKK58_RS27810	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS27815	COG0546	phosphoglycolate phosphatase activity
HKK58_RS27820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKK58_RS27825	COG0402	S-adenosylhomocysteine deaminase activity
HKK58_RS27830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HKK58_RS27840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HKK58_RS27850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKK58_RS27855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKK58_RS27860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HKK58_RS27875	COG0776	regulation of translation
HKK58_RS27890	COG2244	polysaccharide biosynthetic process
HKK58_RS27915	COG0438	transferase activity, transferring glycosyl groups
HKK58_RS27935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKK58_RS27945	COG1555	photosystem II stabilization
HKK58_RS27980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKK58_RS27990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKK58_RS27995	COG2205	protein histidine kinase activity
HKK58_RS28000	COG0745	RESPONSE REGULATOR receiver
HKK58_RS28035	COG3209	COG3209 Rhs family protein
HKK58_RS28050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HKK58_RS28055	COG2259	Doxx family
HKK58_RS28075	COG1131	(ABC) transporter
HKK58_RS28085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK58_RS28090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HKK58_RS28095	COG4181	ATPase activity
HKK58_RS28110	COG1376	ErfK ybiS ycfS ynhG family protein
HKK58_RS28140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HKK58_RS28160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK58_RS28175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKK58_RS28185	COG1764	response to oxidative stress
HKK58_RS28190	COG1846	Transcriptional regulator
HKK58_RS28195	COG0583	DNA-binding transcription factor activity
HKK58_RS28205	COG0583	DNA-binding transcription factor activity
HKK58_RS28215	COG3214	Protein conserved in bacteria
HKK58_RS28220	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HKK58_RS28230	COG1024	Enoyl-CoA hydratase
HKK58_RS28240	COG3384	dioxygenase
HKK58_RS28245	COG0500	methyltransferase
HKK58_RS28250	COG0501	Belongs to the peptidase M48B family
HKK58_RS28255	COG0436	Aminotransferase
HKK58_RS28260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK58_RS28265	COG0386	Belongs to the glutathione peroxidase family
HKK58_RS28270	COG1846	Transcriptional regulator
HKK58_RS28285	COG1956	GAF domain-containing protein
HKK58_RS28290	COG2205	protein histidine kinase activity
HKK58_RS28290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK58_RS28295	COG2197	response regulator
HKK58_RS28330	COG0004	ammonium transporteR
HKK58_RS28350	COG0564	pseudouridine synthase activity
HKK58_RS28360	COG0746	molybdenum cofactor guanylyltransferase activity
HKK58_RS28365	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKK58_RS28375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKK58_RS28385	COG4133	protoheme IX ABC transporter activity
HKK58_RS28405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HKK58_RS28410	COG1138	Cytochrome C-type biogenesis protein
HKK58_RS28420	COG3088	subunit of a heme lyase
HKK58_RS28425	COG4235	cytochrome complex assembly
HKK58_RS28440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HKK58_RS28445	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HKK58_RS28450	COG3639	organic phosphonate transmembrane transporter activity
HKK58_RS28455	COG2188	Transcriptional regulator
HKK58_RS28460	COG3624	Phosphonate C-P lyase system protein PhnG
HKK58_RS28470	COG3626	phosphonate metabolism
HKK58_RS28475	COG3627	carbon phosphorus lyase activity
HKK58_RS28480	COG4107	phosphonate C-P lyase system protein PhnK
HKK58_RS28485	COG4778	phosphonate C-P lyase system protein PhnL
HKK58_RS28490	COG3454	Phosphonate metabolism
HKK58_RS28495	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HKK58_RS28500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK58_RS28515	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HKK58_RS28520	COG0583	DNA-binding transcription factor activity
HKK58_RS28540	COG2814	Major facilitator Superfamily
HKK58_RS28550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKK58_RS28555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK58_RS28565	COG0469	pyruvate kinase activity
HKK58_RS28575	COG2084	Dehydrogenase
HKK58_RS28580	COG3622	Belongs to the hyi family
HKK58_RS28585	COG3960	tartronate-semialdehyde synthase activity
HKK58_RS28595	COG1309	transcriptional regulator
HKK58_RS28600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK58_RS28610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK58_RS28620	COG2354	Protein conserved in bacteria
HKK58_RS28630	COG2853	Lipoprotein
HKK58_RS28650	COG2113	Glycine betaine
HKK58_RS28655	COG3162	membrane
HKK58_RS28660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK58_RS28670	COG2009	succinate dehydrogenase
HKK58_RS28675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HKK58_RS28680	COG1053	succinate dehydrogenase
HKK58_RS28685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKK58_RS28700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK58_RS28705	COG0045	succinate-CoA ligase (ADP-forming) activity
HKK58_RS28740	COG0326	Molecular chaperone. Has ATPase activity
HKK58_RS28750	COG1741	Belongs to the pirin family
HKK58_RS28775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKK58_RS28780	COG5002	protein histidine kinase activity
HKK58_RS28780	COG2205	protein histidine kinase activity
HKK58_RS28780	COG0784	Response regulator, receiver
HKK58_RS28795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HKK58_RS28810	COG1022	Amp-dependent synthetase and ligase
HKK58_RS28835	COG0628	permease
HKK58_RS28840	COG2205	protein histidine kinase activity
HKK58_RS28850	COG0284	orotidine-5'-phosphate decarboxylase activity
HKK58_RS28855	COG2130	NADP-dependent
HKK58_RS28865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK58_RS28870	COG0840	transmembrane signaling receptor activity
HKK58_RS28875	COG2267	carboxylic ester hydrolase activity
HKK58_RS28905	COG0786	glutamate:sodium symporter activity
HKK58_RS28910	COG2197	response regulator
HKK58_RS28915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HKK58_RS28975	COG0811	peptide transport
HKK58_RS29000	COG3540	Alkaline phosphatase
HKK58_RS29020	COG1960	acyl-CoA dehydrogenase activity
HKK58_RS29030	COG0625	glutathione transferase activity
HKK58_RS29035	COG1131	(ABC) transporter
HKK58_RS29040	COG0842	Transport permease protein
HKK58_RS29065	COG2076	Multidrug Resistance protein
HKK58_RS29070	COG0385	Bile acid
HKK58_RS29075	COG2974	May be involved in recombination
HKK58_RS29105	COG0477	Major facilitator Superfamily
HKK58_RS29110	COG0583	DNA-binding transcription factor activity
HKK58_RS29115	COG0745	RESPONSE REGULATOR receiver
HKK58_RS29120	COG2205	protein histidine kinase activity
HKK58_RS29125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HKK58_RS29130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKK58_RS29135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKK58_RS29150	COG2010	Cytochrome c
HKK58_RS29155	COG0545	Peptidyl-prolyl cis-trans isomerase
HKK58_RS29175	COG2200	EAL domain
HKK58_RS29185	COG3321	synthase
HKK58_RS29185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKK58_RS29185	COG4221	oxidoreductase activity
HKK58_RS29185	COG0604	alcohol dehydrogenase
HKK58_RS29195	COG3842	ATPase activity
HKK58_RS29205	COG0395	ABC-type sugar transport system, permease component
HKK58_RS29230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK58_RS29235	COG1121	(ABC) transporter
HKK58_RS29265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKK58_RS29270	COG0066	3-isopropylmalate dehydratase activity
HKK58_RS29275	COG1509	lysine 2,3-aminomutase activity
HKK58_RS29295	COG0583	DNA-binding transcription factor activity
HKK58_RS29300	COG1301	dicarboxylic acid transport
HKK58_RS29305	COG0596	Alpha beta hydrolase
HKK58_RS29320	COG2011	ABC-type metal ion transport system permease component
HKK58_RS29340	COG3829	transcription factor binding
HKK58_RS29350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK58_RS29355	COG0431	NADPH-dependent FMN reductase
HKK58_RS29375	COG0583	DNA-binding transcription factor activity
HKK58_RS29390	COG1028	Short-chain dehydrogenase reductase Sdr
HKK58_RS29400	COG5006	permease, DMT superfamily