locus-tag	class	description
IF189_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IF189_RS00010	COG0592	DNA-directed DNA polymerase activity
IF189_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IF189_RS00020	COG0187	DNA topoisomerase II activity
IF189_RS00025	COG3645	SOS response
IF189_RS00035	COG2205	protein histidine kinase activity
IF189_RS00045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IF189_RS00050	COG0751	glycine-tRNA ligase activity
IF189_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
IF189_RS00060	COG2818	Glycosylase
IF189_RS00075	COG0569	domain protein
IF189_RS00080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IF189_RS00085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IF189_RS00090	COG0242	peptide deformylase activity
IF189_RS00100	COG0758	DNA mediated transformation
IF189_RS00105	COG0009	L-threonylcarbamoyladenylate synthase
IF189_RS00125	COG0156	8-amino-7-oxononanoate synthase activity
IF189_RS00140	COG0408	coproporphyrinogen oxidase activity
IF189_RS00145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IF189_RS00160	COG3119	arylsulfatase activity
IF189_RS00180	COG2851	Citrate transporter
IF189_RS00185	COG0861	Integral membrane protein TerC family
IF189_RS00190	COG1283	sodium-dependent phosphate transmembrane transporter activity
IF189_RS00195	COG0612	Peptidase, M16
IF189_RS00205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IF189_RS00210	COG1127	ABC transporter
IF189_RS00225	COG0700	Nucleoside recognition
IF189_RS00230	COG1301	dicarboxylic acid transport
IF189_RS00240	COG5487	UPF0391 membrane protein
IF189_RS00250	COG2204	response regulator
IF189_RS00255	COG5002	protein histidine kinase activity
IF189_RS00260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IF189_RS00265	COG3023	N-Acetylmuramoyl-L-alanine amidase
IF189_RS00280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF189_RS00295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IF189_RS00315	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IF189_RS00320	COG0735	belongs to the Fur family
IF189_RS00325	COG1121	(ABC) transporter
IF189_RS00330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IF189_RS00345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IF189_RS00350	COG2011	ABC-type metal ion transport system permease component
IF189_RS00365	COG0109	protoheme IX farnesyltransferase activity
IF189_RS00370	COG1612	heme a metabolic process
IF189_RS00395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IF189_RS00400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IF189_RS00405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IF189_RS00415	COG0659	secondary active sulfate transmembrane transporter activity
IF189_RS00460	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IF189_RS00465	COG0339	signal peptide processing
IF189_RS00470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IF189_RS00500	COG1764	response to oxidative stress
IF189_RS00505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IF189_RS00515	COG3360	Dodecin
IF189_RS00530	COG0133	tryptophan synthase activity
IF189_RS00535	COG0159	tryptophan synthase activity
IF189_RS00575	COG0427	acetyl-CoA hydrolase
IF189_RS00595	COG0583	DNA-binding transcription factor activity
IF189_RS00650	COG3712	iron ion homeostasis
IF189_RS00655	COG1595	DNA-templated transcription, initiation
IF189_RS00660	COG0840	transmembrane signaling receptor activity
IF189_RS00685	COG1802	Transcriptional regulator
IF189_RS00695	COG3300	MHYT domain
IF189_RS00695	COG5001	Diguanylate cyclase
IF189_RS00710	COG1538	Outer membrane efflux protein
IF189_RS00715	COG2274	protein secretion by the type I secretion system
IF189_RS00720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS00725	COG2175	clavaminate synthase activity
IF189_RS00735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IF189_RS00740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF189_RS00840	COG0529	Catalyzes the synthesis of activated sulfate
IF189_RS00855	COG0330	HflC and HflK could
IF189_RS00890	COG1289	transmembrane transporter activity
IF189_RS00915	COG5339	Protein conserved in bacteria
IF189_RS00920	COG0457	Tetratricopeptide repeat
IF189_RS00925	COG0726	polysaccharide deacetylase
IF189_RS00925	COG1649	PFAM Uncharacterised BCR, COG1649
IF189_RS00930	COG1215	transferase activity, transferring glycosyl groups
IF189_RS00945	COG2304	oxidoreductase activity
IF189_RS00950	COG1595	DNA-templated transcription, initiation
IF189_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS00975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IF189_RS00985	COG2199	diguanylate cyclase activity
IF189_RS01005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IF189_RS01015	COG4208	sulfate ABC transporter
IF189_RS01020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IF189_RS01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF189_RS01085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF189_RS01110	COG4771	TonB-dependent receptor
IF189_RS01155	COG0765	amino acid transport
IF189_RS01160	COG0765	amino acid transport
IF189_RS01165	COG1126	abc transporter atp-binding protein
IF189_RS01170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS01175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IF189_RS01190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF189_RS01200	COG2011	ABC-type metal ion transport system permease component
IF189_RS01205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IF189_RS01210	COG1464	Belongs to the NlpA lipoprotein family
IF189_RS01235	COG1126	abc transporter atp-binding protein
IF189_RS01240	COG0765	amino acid transport
IF189_RS01245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS01250	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IF189_RS01255	COG1045	serine acetyltransferase
IF189_RS01260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF189_RS01270	COG1609	Transcriptional regulator
IF189_RS01285	COG0667	Aldo Keto reductase
IF189_RS01290	COG2175	clavaminate synthase activity
IF189_RS01295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF189_RS01300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IF189_RS01305	COG4521	taurine ABC transporter
IF189_RS01310	COG2918	glutathione biosynthetic process
IF189_RS01320	COG2183	response to ionizing radiation
IF189_RS01335	COG0189	ligase activity
IF189_RS01340	COG0189	ligase activity
IF189_RS01340	COG4067	protein conserved in archaea
IF189_RS01345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IF189_RS01355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IF189_RS01360	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IF189_RS01395	COG0514	ATP-dependent DNA helicase (RecQ)
IF189_RS01400	COG1024	Enoyl-CoA hydratase
IF189_RS01400	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF189_RS01420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IF189_RS01425	COG0583	DNA-binding transcription factor activity
IF189_RS01430	COG1652	LysM domain
IF189_RS01435	COG1011	Hydrolase
IF189_RS01440	COG0494	nUDIX hydrolase
IF189_RS01445	COG1218	3'(2'),5'-bisphosphate nucleotidase
IF189_RS01470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IF189_RS01475	COG2957	Belongs to the agmatine deiminase family
IF189_RS01525	COG1942	4-Oxalocrotonate Tautomerase
IF189_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS01540	COG1724	mRNA binding
IF189_RS01545	COG1598	PFAM Uncharacterised protein family UPF0150
IF189_RS01560	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IF189_RS01595	COG4215	(ABC) transporter
IF189_RS01600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS01630	COG4804	nuclease activity
IF189_RS01665	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IF189_RS01670	COG1194	a g-specific adenine glycosylase
IF189_RS01680	COG2223	nitrite transmembrane transporter activity
IF189_RS01685	COG0131	Imidazoleglycerol-phosphate dehydratase
IF189_RS01690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IF189_RS01700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IF189_RS01705	COG0107	imidazoleglycerol-phosphate synthase activity
IF189_RS01720	COG2861	carbohydrate metabolic process
IF189_RS01725	COG0793	Belongs to the peptidase S41A family
IF189_RS01730	COG4942	peptidase
IF189_RS01735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IF189_RS01750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IF189_RS01755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IF189_RS01770	COG3852	Histidine kinase
IF189_RS01790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF189_RS01790	COG0301	tRNA thio-modification
IF189_RS01795	COG1217	gtp-binding protein TYPA
IF189_RS01805	COG0058	SHG alpha-glucan phosphorylase activity
IF189_RS01820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IF189_RS01840	COG3040	lipid binding
IF189_RS01845	COG0402	S-adenosylhomocysteine deaminase activity
IF189_RS01850	COG2188	Transcriptional regulator
IF189_RS01860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IF189_RS01865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IF189_RS01875	COG4176	ABC-type proline glycine betaine transport system permease component
IF189_RS01880	COG0517	IMP dehydrogenase activity
IF189_RS01880	COG4175	Glycine betaine
IF189_RS01885	COG2986	histidine ammonia-lyase
IF189_RS01890	COG2986	histidine ammonia-lyase
IF189_RS01895	COG1228	amidohydrolase
IF189_RS01910	COG0657	acetylesterase activity
IF189_RS01915	COG0596	Alpha beta hydrolase
IF189_RS01920	COG1490	D-aminoacyl-tRNA deacylase activity
IF189_RS01925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IF189_RS01930	COG2943	transferase activity, transferring hexosyl groups
IF189_RS01940	COG0765	amino acid transport
IF189_RS01950	COG0840	transmembrane signaling receptor activity
IF189_RS01965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IF189_RS01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IF189_RS01975	COG0140	phosphoribosyl-ATP diphosphatase activity
IF189_RS01980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IF189_RS01985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IF189_RS01995	COG2226	methyltransferase
IF189_RS02040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IF189_RS02045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IF189_RS02055	COG0018	arginyl-trna synthetase
IF189_RS02060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IF189_RS02065	COG0254	rRNA binding
IF189_RS02075	COG0281	malic enzyme
IF189_RS02110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IF189_RS02115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IF189_RS02125	COG0067	glutamate synthase
IF189_RS02125	COG0069	glutamate synthase activity
IF189_RS02125	COG0070	glutamate synthase
IF189_RS02130	COG0493	'glutamate synthase
IF189_RS02135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IF189_RS02140	COG2814	Major facilitator Superfamily
IF189_RS02145	COG0583	DNA-binding transcription factor activity
IF189_RS02155	COG3657	addiction module killer protein
IF189_RS02160	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF189_RS02170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF189_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS02185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF189_RS02225	COG2986	histidine ammonia-lyase
IF189_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF189_RS02250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF189_RS02255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF189_RS02270	COG1192	Involved in chromosome partitioning
IF189_RS02275	COG3118	belongs to the thioredoxin family
IF189_RS02280	COG4680	protein conserved in bacteria
IF189_RS02285	COG5499	transcription regulator containing HTH domain
IF189_RS02290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IF189_RS02295	COG1196	nuclear chromosome segregation
IF189_RS02295	COG3264	Mechanosensitive ion channel
IF189_RS02300	COG3263	regulation of cellular component size
IF189_RS02320	COG0840	transmembrane signaling receptor activity
IF189_RS02325	COG1960	acyl-CoA dehydrogenase activity
IF189_RS02330	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IF189_RS02330	COG0506	proline dehydrogenase activity
IF189_RS02330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IF189_RS02370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IF189_RS02375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF189_RS02400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IF189_RS02405	COG0859	PFAM glycosyl transferase family 9
IF189_RS02410	COG0859	PFAM glycosyl transferase family 9
IF189_RS02415	COG0438	transferase activity, transferring glycosyl groups
IF189_RS02450	COG2192	nodulation
IF189_RS02455	COG0438	transferase activity, transferring glycosyl groups
IF189_RS02470	COG0438	transferase activity, transferring glycosyl groups
IF189_RS02475	COG1215	transferase activity, transferring glycosyl groups
IF189_RS02495	COG1132	(ABC) transporter
IF189_RS02505	COG0529	Catalyzes the synthesis of activated sulfate
IF189_RS02510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IF189_RS02510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IF189_RS02520	COG0667	Aldo Keto reductase
IF189_RS02540	COG1519	Transferase
IF189_RS02545	COG1538	Outer membrane efflux protein
IF189_RS02550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IF189_RS02565	COG0494	nUDIX hydrolase
IF189_RS02575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IF189_RS02580	COG3150	esterase
IF189_RS02595	COG3577	Aspartyl protease
IF189_RS02615	COG0560	Phosphoserine phosphatase
IF189_RS02615	COG3830	Belongs to the UPF0237 family
IF189_RS02630	COG0688	phosphatidylethanolamine metabolic process
IF189_RS02655	COG1162	GTPase activity
IF189_RS02660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IF189_RS02665	COG2860	membrane
IF189_RS02675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IF189_RS02675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IF189_RS02680	COG0802	atpase or kinase
IF189_RS02685	COG0860	N-Acetylmuramoyl-L-alanine amidase
IF189_RS02690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IF189_RS02695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IF189_RS02700	COG1923	regulation of RNA biosynthetic process
IF189_RS02705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IF189_RS02710	COG0330	HflC and HflK could
IF189_RS02715	COG0330	HflC and HflK could
IF189_RS02720	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IF189_RS02725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IF189_RS02735	COG1178	ABC-type Fe3 transport system permease component
IF189_RS02740	COG1840	ABC-type Fe3 transport system, periplasmic component
IF189_RS02760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF189_RS02765	COG0360	Binds together with S18 to 16S ribosomal RNA
IF189_RS02770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IF189_RS02780	COG0359	binds to the 23S rRNA
IF189_RS02785	COG0305	Participates in initiation and elongation during chromosome replication
IF189_RS02790	COG1032	radical SAM domain protein
IF189_RS02800	COG2308	Evidence 4 Homologs of previously reported genes of
IF189_RS02800	COG2307	Protein conserved in bacteria
IF189_RS02825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IF189_RS02830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IF189_RS02835	COG0583	DNA-binding transcription factor activity
IF189_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS02845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS02855	COG0559	Belongs to the binding-protein-dependent transport system permease family
IF189_RS02875	COG4221	oxidoreductase activity
IF189_RS02895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IF189_RS02900	COG0830	nickel cation binding
IF189_RS02905	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IF189_RS02910	COG1309	transcriptional regulator
IF189_RS02920	COG2982	Protein involved in outer membrane biogenesis
IF189_RS02930	COG0583	DNA-binding transcription factor activity
IF189_RS02935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IF189_RS02945	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IF189_RS02950	COG0697	spore germination
IF189_RS02970	COG0443	Heat shock 70 kDa protein
IF189_RS02975	COG0484	heat shock protein binding
IF189_RS02980	COG0789	Transcriptional regulator
IF189_RS02995	COG0804	urea catabolic process
IF189_RS03000	COG0832	Belongs to the urease beta subunit family
IF189_RS03015	COG0831	urea catabolic process
IF189_RS03020	COG0829	nickel cation binding
IF189_RS03030	COG0411	ABC transporter
IF189_RS03045	COG0683	leucine binding
IF189_RS03050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF189_RS03060	COG1120	ATPase activity
IF189_RS03105	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IF189_RS03120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF189_RS03145	COG2095	MarC family integral membrane protein
IF189_RS03165	COG0151	Belongs to the GarS family
IF189_RS03170	COG0138	bifunctional purine biosynthesis protein purh
IF189_RS03180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IF189_RS03190	COG2264	protein methyltransferase activity
IF189_RS03250	COG0023	Translation Initiation Factor
IF189_RS03255	COG1166	arginine decarboxylase activity
IF189_RS03270	COG0657	acetylesterase activity
IF189_RS03275	COG0534	Mate efflux family protein
IF189_RS03290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF189_RS03360	COG4964	Belongs to the GSP D family
IF189_RS03395	COG2030	dehydratase
IF189_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS03405	COG0183	Belongs to the thiolase family
IF189_RS03410	COG0840	transmembrane signaling receptor activity
IF189_RS03430	COG2217	Heavy metal translocating P-type atpase
IF189_RS03440	COG2217	Heavy metal translocating P-type atpase
IF189_RS03455	COG0604	alcohol dehydrogenase
IF189_RS03465	COG0583	DNA-binding transcription factor activity
IF189_RS03475	COG0477	Major facilitator Superfamily
IF189_RS03480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IF189_RS03495	COG0387	Pfam Sodium calcium exchanger
IF189_RS03520	COG1079	Belongs to the binding-protein-dependent transport system permease family
IF189_RS03525	COG4603	Belongs to the binding-protein-dependent transport system permease family
IF189_RS03530	COG3845	ABC transporter
IF189_RS03540	COG1309	transcriptional regulator
IF189_RS03585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IF189_RS03590	COG1074	ATP-dependent DNA helicase activity
IF189_RS03595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF189_RS03605	COG2199	diguanylate cyclase activity
IF189_RS03610	COG2885	chlorophyll binding
IF189_RS03635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IF189_RS03655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IF189_RS03665	COG2084	Dehydrogenase
IF189_RS03675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS03680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF189_RS03690	COG0640	Transcriptional regulator
IF189_RS03695	COG3161	chorismate lyase activity
IF189_RS03705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IF189_RS03710	COG0583	DNA-binding transcription factor activity
IF189_RS03725	COG2249	NAD(P)H dehydrogenase (quinone) activity
IF189_RS03730	COG0583	DNA-binding transcription factor activity
IF189_RS03740	COG2192	nodulation
IF189_RS03760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IF189_RS03780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IF189_RS03785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IF189_RS03815	COG0840	transmembrane signaling receptor activity
IF189_RS03830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IF189_RS03845	COG4983	Phage plasmid primase, P4 family domain protein
IF189_RS03930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IF189_RS03960	COG0582	viral genome integration into host DNA
IF189_RS03990	COG0247	lactate metabolic process
IF189_RS03995	COG1620	l-lactate permease
IF189_RS04005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IF189_RS04010	COG0733	neurotransmitter:sodium symporter activity
IF189_RS04020	COG2914	Belongs to the UPF0125 (RnfH) family
IF189_RS04025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF189_RS04030	COG0735	belongs to the Fur family
IF189_RS04035	COG0497	DNA recombination
IF189_RS04040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IF189_RS04045	COG0443	Heat shock 70 kDa protein
IF189_RS04050	COG0484	heat shock protein binding
IF189_RS04055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IF189_RS04060	COG0505	Belongs to the CarA family
IF189_RS04065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IF189_RS04070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF189_RS04085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IF189_RS04095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IF189_RS04100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF189_RS04105	COG0149	triose-phosphate isomerase activity
IF189_RS04110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IF189_RS04125	COG0779	Required for maturation of 30S ribosomal subunits
IF189_RS04130	COG0195	Participates in both transcription termination and antitermination
IF189_RS04135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IF189_RS04140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IF189_RS04145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IF189_RS04150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IF189_RS04155	COG1185	polyribonucleotide nucleotidyltransferase activity
IF189_RS04185	COG3023	N-Acetylmuramoyl-L-alanine amidase
IF189_RS04205	COG0084	hydrolase, TatD family'
IF189_RS04210	COG1609	Transcriptional regulator
IF189_RS04220	COG1105	Belongs to the carbohydrate kinase PfkB family
IF189_RS04225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF189_RS04225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF189_RS04225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IF189_RS04235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IF189_RS04240	COG4774	siderophore transport
IF189_RS04245	COG3128	pkhd-type hydroxylase
IF189_RS04265	COG0019	diaminopimelate decarboxylase activity
IF189_RS04290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IF189_RS04305	COG4608	Belongs to the ABC transporter superfamily
IF189_RS04310	COG0444	Belongs to the ABC transporter superfamily
IF189_RS04315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF189_RS04320	COG0601	transmembrane transport
IF189_RS04325	COG0747	negative chemotaxis
IF189_RS04335	COG0747	negative chemotaxis
IF189_RS04340	COG0747	negative chemotaxis
IF189_RS04345	COG0747	negative chemotaxis
IF189_RS04370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IF189_RS04375	COG4178	(ABC) transporter
IF189_RS04400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF189_RS04410	COG2271	Major facilitator Superfamily
IF189_RS04415	COG2721	sulfolactate sulfo-lyase activity
IF189_RS04425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF189_RS04435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IF189_RS04440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IF189_RS04445	COG0154	amidase activity
IF189_RS04450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IF189_RS04455	COG1077	Cell shape determining protein MreB Mrl
IF189_RS04460	COG1792	Involved in formation and maintenance of cell shape
IF189_RS04465	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IF189_RS04470	COG0424	maF-like protein
IF189_RS04475	COG1530	ribonuclease E activity
IF189_RS04485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IF189_RS04490	COG0312	modulator of DNA gyrase
IF189_RS04495	COG3028	Belongs to the UPF0307 family
IF189_RS04500	COG0312	modulator of DNA gyrase
IF189_RS04535	COG1660	Displays ATPase and GTPase activities
IF189_RS04545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IF189_RS04550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IF189_RS04555	COG1137	ATPase activity
IF189_RS04570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IF189_RS04580	COG1127	ABC transporter
IF189_RS04585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IF189_RS04590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IF189_RS04605	COG5007	Belongs to the BolA IbaG family
IF189_RS04610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IF189_RS04615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IF189_RS04620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IF189_RS04625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IF189_RS04630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IF189_RS04640	COG0175	sulfate reduction
IF189_RS04650	COG0204	Acyl-transferase
IF189_RS04655	COG0857	belongs to the CobB CobQ family
IF189_RS04655	COG0280	phosphate acetyltransferase
IF189_RS04665	COG1047	Peptidyl-prolyl cis-trans
IF189_RS04670	COG0386	Belongs to the glutathione peroxidase family
IF189_RS04685	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IF189_RS04690	COG0492	ferredoxin-NADP+ reductase activity
IF189_RS04705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IF189_RS04710	COG0302	gtp cyclohydrolase
IF189_RS04725	COG0789	Transcriptional regulator
IF189_RS04735	COG1366	Belongs to the anti-sigma-factor antagonist family
IF189_RS04745	COG0583	DNA-binding transcription factor activity
IF189_RS04750	COG1380	Effector of murein hydrolase LrgA
IF189_RS04755	COG1346	cytolysis
IF189_RS04770	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS04785	COG2909	trisaccharide binding
IF189_RS04800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IF189_RS04805	COG0179	Fumarylacetoacetate (FAA) hydrolase
IF189_RS04815	COG2271	Major facilitator Superfamily
IF189_RS04825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IF189_RS04845	COG0814	amino acid
IF189_RS04850	COG1760	l-serine dehydratase
IF189_RS04855	COG0583	DNA-binding transcription factor activity
IF189_RS04865	COG4772	TonB-dependent receptor
IF189_RS04870	COG3712	iron ion homeostasis
IF189_RS04875	COG1595	DNA-templated transcription, initiation
IF189_RS04895	COG4774	siderophore transport
IF189_RS04915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF189_RS04920	COG0583	DNA-binding transcription factor activity
IF189_RS04940	COG1566	PFAM secretion protein HlyD family protein
IF189_RS04965	COG0300	oxidoreductase activity
IF189_RS04980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IF189_RS04980	COG0662	Cupin 2, conserved barrel domain protein
IF189_RS04995	COG1696	Membrane protein involved in D-alanine export
IF189_RS05010	COG3420	alginic acid biosynthetic process
IF189_RS05020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IF189_RS05025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS05030	COG1215	transferase activity, transferring glycosyl groups
IF189_RS05040	COG3022	response to hydroperoxide
IF189_RS05050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IF189_RS05055	COG0315	cyclic pyranopterin monophosphate synthase activity
IF189_RS05060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IF189_RS05090	COG0513	Belongs to the DEAD box helicase family
IF189_RS05095	COG0400	carboxylic ester hydrolase activity
IF189_RS05100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS05105	COG4597	amino acid ABC transporter
IF189_RS05110	COG0765	amino acid transport
IF189_RS05115	COG1126	abc transporter atp-binding protein
IF189_RS05120	COG2186	Transcriptional regulator
IF189_RS05125	COG2807	transmembrane transport
IF189_RS05135	COG2827	Endonuclease containing a URI domain
IF189_RS05150	COG3081	Nucleoid-associated protein
IF189_RS05160	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IF189_RS05165	COG0525	valine-tRNA ligase activity
IF189_RS05180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IF189_RS05185	COG0795	lipopolysaccharide-transporting ATPase activity
IF189_RS05190	COG0795	lipopolysaccharide-transporting ATPase activity
IF189_RS05195	COG0481	GTPase activity
IF189_RS05200	COG0681	Belongs to the peptidase S26 family
IF189_RS05205	COG0571	ribonuclease III activity
IF189_RS05210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IF189_RS05215	COG1381	Involved in DNA repair and RecF pathway recombination
IF189_RS05220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IF189_RS05225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IF189_RS05230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IF189_RS05230	COG0047	phosphoribosylformylglycinamidine synthase activity
IF189_RS05245	COG2190	(PTS) system
IF189_RS05245	COG1263	PTS System
IF189_RS05245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF189_RS05250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF189_RS05250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IF189_RS05255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IF189_RS05260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IF189_RS05265	COG2188	Transcriptional regulator
IF189_RS05280	COG0494	nUDIX hydrolase
IF189_RS05300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IF189_RS05305	COG0477	Major facilitator Superfamily
IF189_RS05310	COG4536	flavin adenine dinucleotide binding
IF189_RS05320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IF189_RS05325	COG0228	four-way junction DNA binding
IF189_RS05330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IF189_RS05335	COG0336	Belongs to the RNA methyltransferase TrmD family
IF189_RS05340	COG0335	large ribosomal subunit rRNA binding
IF189_RS05345	COG1607	acyl-coa hydrolase
IF189_RS05355	COG4974	Belongs to the 'phage' integrase family
IF189_RS05375	COG2205	protein histidine kinase activity
IF189_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS05395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IF189_RS05410	COG1902	pentaerythritol trinitrate reductase activity
IF189_RS05420	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IF189_RS05445	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS05450	COG1177	transmembrane transport
IF189_RS05455	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS05460	COG3842	ATPase activity
IF189_RS05465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IF189_RS05475	COG0583	DNA-binding transcription factor activity
IF189_RS05530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IF189_RS05530	COG0457	Tetratricopeptide repeat
IF189_RS05545	COG2201	protein-glutamate methylesterase activity
IF189_RS05550	COG3706	GGDEF domain
IF189_RS05550	COG2203	Gaf domain
IF189_RS05550	COG5001	Diguanylate cyclase
IF189_RS05550	COG4251	negative regulation of phosphorylation
IF189_RS05560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IF189_RS05580	COG1073	alpha beta
IF189_RS05605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IF189_RS05610	COG0563	adenylate kinase activity
IF189_RS05615	COG1214	PFAM Peptidase M22, glycoprotease
IF189_RS05625	COG1801	Protein of unknown function DUF72
IF189_RS05640	COG0742	ribosomal rna small subunit methyltransferase
IF189_RS05650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS05685	COG2937	Belongs to the GPAT DAPAT family
IF189_RS05700	COG2226	methyltransferase
IF189_RS05705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IF189_RS05715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IF189_RS05725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IF189_RS05730	COG2171	N-acyltransferase activity
IF189_RS05735	COG1393	Belongs to the ArsC family
IF189_RS05740	COG0025	NhaP-type Na H and K H
IF189_RS05750	COG0436	Aminotransferase
IF189_RS05755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IF189_RS05760	COG0024	Methionine aminopeptidase
IF189_RS05765	COG0052	Belongs to the universal ribosomal protein uS2 family
IF189_RS05770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IF189_RS05775	COG0528	UMP kinase activity
IF189_RS05780	COG0233	cytoplasmic translational termination
IF189_RS05785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IF189_RS05795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IF189_RS05815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF189_RS05820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF189_RS05825	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF189_RS05830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF189_RS05835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IF189_RS05840	COG0587	DNA-directed DNA polymerase activity
IF189_RS05845	COG0825	malonyl-CoA metabolic process
IF189_RS05850	COG0037	tRNA processing
IF189_RS05855	COG0504	CTP synthase activity
IF189_RS05860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IF189_RS05865	COG0148	phosphopyruvate hydratase activity
IF189_RS05875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IF189_RS05885	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IF189_RS05890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IF189_RS05895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IF189_RS05900	COG0585	pseudouridine synthase activity
IF189_RS05905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IF189_RS05910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IF189_RS05930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IF189_RS06055	COG4386	tail sheath protein
IF189_RS06090	COG4381	Mu-like prophage protein gp46
IF189_RS06120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IF189_RS06155	COG3179	chitinase
IF189_RS06165	COG1546	Belongs to the CinA family
IF189_RS06170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IF189_RS06175	COG2137	regulation of response to DNA damage stimulus
IF189_RS06195	COG3148	PFAM DTW domain containing protein
IF189_RS06210	COG0583	DNA-binding transcription factor activity
IF189_RS06230	COG4807	Protein conserved in bacteria
IF189_RS06245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IF189_RS06250	COG3158	transport of potassium into the cell
IF189_RS06280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IF189_RS06290	COG0442	prolyl-tRNA aminoacylation
IF189_RS06295	COG2211	Major facilitator Superfamily
IF189_RS06310	COG1278	Cold shock
IF189_RS06315	COG0717	Belongs to the dCTP deaminase family
IF189_RS06330	COG1201	RNA secondary structure unwinding
IF189_RS06345	COG4160	amino acid transport
IF189_RS06360	COG1793	dna ligase
IF189_RS06370	COG2366	antibiotic biosynthetic process
IF189_RS06375	COG0625	glutathione transferase activity
IF189_RS06385	COG0653	protein targeting
IF189_RS06395	COG3012	SEC-C Motif Domain Protein
IF189_RS06430	COG1199	ATP-dependent helicase activity
IF189_RS06440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IF189_RS06450	COG0259	pyridoxamine-phosphate oxidase activity
IF189_RS06480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF189_RS06490	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IF189_RS06510	COG0583	DNA-binding transcription factor activity
IF189_RS06525	COG3220	belongs to the UPF0276 family
IF189_RS06575	COG2084	Dehydrogenase
IF189_RS06585	COG0727	PFAM Uncharacterised protein family (UPF0153)
IF189_RS06590	COG2271	Major facilitator Superfamily
IF189_RS06595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IF189_RS06615	COG0306	phosphate transporter
IF189_RS06625	COG1414	Transcriptional regulator
IF189_RS06630	COG2814	Major facilitator Superfamily
IF189_RS06635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IF189_RS06640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IF189_RS06645	COG0183	Belongs to the thiolase family
IF189_RS06650	COG3485	protocatechuate 3,4-dioxygenase
IF189_RS06655	COG3485	protocatechuate 3,4-dioxygenase
IF189_RS06660	COG0477	Major facilitator Superfamily
IF189_RS06670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IF189_RS06675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF189_RS06720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS06730	COG1902	pentaerythritol trinitrate reductase activity
IF189_RS06735	COG2814	Major facilitator Superfamily
IF189_RS06780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF189_RS06790	COG1704	LemA family
IF189_RS06795	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IF189_RS06810	COG0697	spore germination
IF189_RS06815	COG0693	protein deglycase activity
IF189_RS06820	COG3422	double-strand break repair
IF189_RS06825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF189_RS06830	COG0235	Class ii aldolase
IF189_RS06835	COG1396	sequence-specific DNA binding
IF189_RS06845	COG1454	alcohol dehydrogenase
IF189_RS06910	COG4106	trans-aconitate 2-methyltransferase activity
IF189_RS06985	COG2267	carboxylic ester hydrolase activity
IF189_RS07020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IF189_RS07070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IF189_RS07100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IF189_RS07105	COG4783	chaperone-mediated protein folding
IF189_RS07110	COG0425	Belongs to the sulfur carrier protein TusA family
IF189_RS07115	COG0628	permease
IF189_RS07120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IF189_RS07130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF189_RS07135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IF189_RS07140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IF189_RS07145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IF189_RS07165	COG0463	Glycosyl transferase, family 2
IF189_RS07205	COG2807	transmembrane transport
IF189_RS07210	COG2194	sulfuric ester hydrolase activity
IF189_RS07220	COG3100	YcgL domain-containing protein
IF189_RS07235	COG2983	Belongs to the UPF0260 family
IF189_RS07275	COG1770	oligopeptidase
IF189_RS07285	COG0121	glutamine amidotransferase
IF189_RS07295	COG0583	DNA-binding transcription factor activity
IF189_RS07300	COG2814	Major facilitator Superfamily
IF189_RS07305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IF189_RS07310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IF189_RS07315	COG1984	allophanate hydrolase subunit 2
IF189_RS07325	COG0542	response to heat
IF189_RS07340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IF189_RS07375	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IF189_RS07380	COG1643	Atp-dependent helicase
IF189_RS07390	COG1595	DNA-templated transcription, initiation
IF189_RS07400	COG2188	Transcriptional regulator
IF189_RS07410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IF189_RS07415	COG1132	(ABC) transporter
IF189_RS07440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IF189_RS07460	COG0583	DNA-binding transcription factor activity
IF189_RS07465	COG1335	isochorismatase
IF189_RS07470	COG0668	transmembrane transport
IF189_RS07475	COG0513	Belongs to the DEAD box helicase family
IF189_RS07520	COG2996	Protein conserved in bacteria
IF189_RS07530	COG0697	spore germination
IF189_RS07540	COG0583	DNA-binding transcription factor activity
IF189_RS07555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF189_RS07585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS07610	COG2832	Protein of unknown function (DUF454)
IF189_RS07635	COG1752	Esterase of the alpha-beta hydrolase superfamily
IF189_RS07650	COG2207	Transcriptional regulator
IF189_RS07675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IF189_RS07680	COG0778	Nitroreductase
IF189_RS07685	COG0642	Histidine kinase
IF189_RS07695	COG0745	RESPONSE REGULATOR receiver
IF189_RS07705	COG2350	Protein conserved in bacteria
IF189_RS07710	COG2917	probably involved in intracellular septation
IF189_RS07720	COG0009	L-threonylcarbamoyladenylate synthase
IF189_RS07725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IF189_RS07730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IF189_RS07745	COG1113	amino acid transport
IF189_RS07775	COG2154	pterin-4-alpha-carbinolamine dehydratase
IF189_RS07790	COG4787	bacterial-type flagellum-dependent cell motility
IF189_RS07800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IF189_RS07805	COG1706	bacterial-type flagellum-dependent cell motility
IF189_RS07815	COG1256	bacterial-type flagellum assembly
IF189_RS07820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF189_RS07825	COG1216	Glycosyl transferase, family 2
IF189_RS07825	COG0438	transferase activity, transferring glycosyl groups
IF189_RS07850	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IF189_RS07860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF189_RS07875	COG1216	Glycosyl transferase, family 2
IF189_RS07875	COG0438	transferase activity, transferring glycosyl groups
IF189_RS07880	COG1086	Polysaccharide biosynthesis protein
IF189_RS07885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IF189_RS07895	COG1083	cytidylyl-transferase
IF189_RS07905	COG2089	acid synthase
IF189_RS07910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IF189_RS07965	COG1677	Flagellar hook-basal body complex protein FliE
IF189_RS08000	COG0745	RESPONSE REGULATOR receiver
IF189_RS08015	COG1580	Controls the rotational direction of flagella during chemotaxis
IF189_RS08040	COG1987	bacterial-type flagellum assembly
IF189_RS08085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IF189_RS08090	COG2198	Histidine kinase
IF189_RS08090	COG0643	Histidine kinase
IF189_RS08090	COG0784	Response regulator, receiver
IF189_RS08095	COG2201	protein-glutamate methylesterase activity
IF189_RS08100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IF189_RS08110	COG1192	Involved in chromosome partitioning
IF189_RS08120	COG0835	chemotaxis
IF189_RS08140	COG4133	protoheme IX ABC transporter activity
IF189_RS08160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IF189_RS08165	COG1138	Cytochrome C-type biogenesis protein
IF189_RS08175	COG3088	subunit of a heme lyase
IF189_RS08190	COG1569	PIN domain
IF189_RS08195	COG3311	Transcriptional regulator
IF189_RS08200	COG0583	DNA-binding transcription factor activity
IF189_RS08205	COG1598	PFAM Uncharacterised protein family UPF0150
IF189_RS08210	COG2814	Major facilitator Superfamily
IF189_RS08220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IF189_RS08225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF189_RS08230	COG4413	Urea transporter
IF189_RS08235	COG0469	pyruvate kinase activity
IF189_RS08245	COG2084	Dehydrogenase
IF189_RS08250	COG3622	Belongs to the hyi family
IF189_RS08255	COG3960	tartronate-semialdehyde synthase activity
IF189_RS08270	COG1309	transcriptional regulator
IF189_RS08280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF189_RS08285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF189_RS08295	COG2354	Protein conserved in bacteria
IF189_RS08300	COG3152	Membrane
IF189_RS08305	COG2853	Lipoprotein
IF189_RS08325	COG2113	Glycine betaine
IF189_RS08330	COG3162	membrane
IF189_RS08335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF189_RS08350	COG2009	succinate dehydrogenase
IF189_RS08355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IF189_RS08360	COG1053	succinate dehydrogenase
IF189_RS08365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IF189_RS08380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF189_RS08385	COG0045	succinate-CoA ligase (ADP-forming) activity
IF189_RS08425	COG0326	Molecular chaperone. Has ATPase activity
IF189_RS08440	COG1741	Belongs to the pirin family
IF189_RS08465	COG0477	Major facilitator Superfamily
IF189_RS08480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IF189_RS08485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IF189_RS08495	COG0628	permease
IF189_RS08500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IF189_RS08505	COG0791	NLP P60 protein
IF189_RS08510	COG0791	NLP P60 protein
IF189_RS08530	COG1797	cobyrinic acid a,c-diamide synthase activity
IF189_RS08535	COG0778	Nitroreductase
IF189_RS08550	COG1492	cobalamin metabolic process
IF189_RS08560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IF189_RS08570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IF189_RS08645	COG2076	Multidrug Resistance protein
IF189_RS08650	COG0385	Bile acid
IF189_RS08655	COG2974	May be involved in recombination
IF189_RS08680	COG0753	catalase activity
IF189_RS08685	COG2010	Cytochrome c
IF189_RS08690	COG0545	Peptidyl-prolyl cis-trans isomerase
IF189_RS08715	COG3209	COG3209 Rhs family protein
IF189_RS08725	COG2200	EAL domain
IF189_RS08730	COG0793	Belongs to the peptidase S41A family
IF189_RS08735	COG4221	oxidoreductase activity
IF189_RS08735	COG3321	synthase
IF189_RS08735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IF189_RS08735	COG0604	alcohol dehydrogenase
IF189_RS08745	COG3842	ATPase activity
IF189_RS08755	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS08780	COG0668	transmembrane transport
IF189_RS08790	COG1362	aminopeptidase activity
IF189_RS08795	COG0564	pseudouridine synthase activity
IF189_RS08800	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IF189_RS08805	COG2894	cell division
IF189_RS08810	COG0850	regulation of cytokinetic process
IF189_RS08815	COG1560	Kdo2-lipid A biosynthetic process
IF189_RS08835	COG2233	PERMEase
IF189_RS08845	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IF189_RS08850	COG4266	Belongs to the allantoicase family
IF189_RS08880	COG2252	PERMEase
IF189_RS08890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS08900	COG0302	gtp cyclohydrolase
IF189_RS08905	COG2840	Smr protein MutS2
IF189_RS08935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IF189_RS08945	COG0235	Class ii aldolase
IF189_RS08950	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IF189_RS08955	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IF189_RS08965	COG0318	PFAM AMP-dependent synthetase and ligase
IF189_RS08985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IF189_RS09000	COG2308	Evidence 4 Homologs of previously reported genes of
IF189_RS09010	COG1305	Transglutaminase-like
IF189_RS09025	COG0183	Belongs to the thiolase family
IF189_RS09030	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF189_RS09030	COG1024	Enoyl-CoA hydratase
IF189_RS09035	COG0519	Catalyzes the synthesis of GMP from XMP
IF189_RS09035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IF189_RS09040	COG0598	Magnesium transport protein CorA
IF189_RS09060	COG0393	Putative heavy-metal-binding
IF189_RS09095	COG3209	COG3209 Rhs family protein
IF189_RS09095	COG3209	COG3209 Rhs family protein
IF189_RS09100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF189_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS09120	COG1953	Uracil, thiamine, allantoin
IF189_RS09130	COG0560	Phosphoserine phosphatase
IF189_RS09150	COG4067	protein conserved in archaea
IF189_RS09150	COG0189	ligase activity
IF189_RS09155	COG1802	Transcriptional regulator
IF189_RS09165	COG0372	Belongs to the citrate synthase family
IF189_RS09170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IF189_RS09185	COG1116	anion transmembrane transporter activity
IF189_RS09195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IF189_RS09210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IF189_RS09225	COG0668	transmembrane transport
IF189_RS09240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IF189_RS09245	COG0243	molybdopterin cofactor binding
IF189_RS09250	COG2146	nitrite reductase [NAD(P)H] activity
IF189_RS09255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF189_RS09260	COG2815	serine threonine protein kinase
IF189_RS09260	COG0515	serine threonine protein kinase
IF189_RS09265	COG2223	nitrite transmembrane transporter activity
IF189_RS09270	COG3707	response regulator
IF189_RS09275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF189_RS09275	COG1116	anion transmembrane transporter activity
IF189_RS09280	COG0167	dihydroorotate dehydrogenase activity
IF189_RS09285	COG3130	regulation of translation
IF189_RS09290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF189_RS09290	COG0116	Belongs to the methyltransferase superfamily
IF189_RS09300	COG2027	D-alanyl-D-alanine carboxypeptidase
IF189_RS09305	COG3171	Protein conserved in bacteria
IF189_RS09310	COG3135	benzoate transporter
IF189_RS09315	COG1802	Transcriptional regulator
IF189_RS09320	COG0402	S-adenosylhomocysteine deaminase activity
IF189_RS09350	COG3115	cell septum assembly
IF189_RS09355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IF189_RS09380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IF189_RS09385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IF189_RS09390	COG2130	NADP-dependent
IF189_RS09395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IF189_RS09400	COG1960	acyl-CoA dehydrogenase activity
IF189_RS09405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IF189_RS09410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF189_RS09445	COG0348	domain, Protein
IF189_RS09460	COG2010	Cytochrome c
IF189_RS09475	COG3278	Belongs to the heme-copper respiratory oxidase family
IF189_RS09480	COG2010	Cytochrome c
IF189_RS09495	COG3278	Belongs to the heme-copper respiratory oxidase family
IF189_RS09550	COG0840	transmembrane signaling receptor activity
IF189_RS09565	COG4977	sequence-specific DNA binding
IF189_RS09580	COG3387	PFAM Glycoside hydrolase 15-related
IF189_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS09595	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IF189_RS09620	COG0657	acetylesterase activity
IF189_RS09660	COG1136	(ABC) transporter
IF189_RS09660	COG0577	efflux transmembrane transporter activity
IF189_RS09665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS09680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IF189_RS09695	COG2197	response regulator
IF189_RS09700	COG2205	protein histidine kinase activity
IF189_RS09700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS09705	COG0656	L-ascorbic acid biosynthetic process
IF189_RS09740	COG2233	PERMEase
IF189_RS09760	COG0556	nucleotide-excision repair
IF189_RS09775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF189_RS09805	COG0596	Alpha beta hydrolase
IF189_RS09815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IF189_RS09830	COG2214	Heat shock protein DnaJ domain protein
IF189_RS09835	COG0443	Heat shock 70 kDa protein
IF189_RS09850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IF189_RS09855	COG0066	3-isopropylmalate dehydratase activity
IF189_RS09860	COG2226	methyltransferase
IF189_RS09865	COG0473	3-isopropylmalate dehydrogenase activity
IF189_RS09890	COG0135	phosphoribosylanthranilate isomerase activity
IF189_RS09895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IF189_RS09900	COG0285	dihydrofolate synthase activity
IF189_RS09910	COG1286	toxin biosynthetic process
IF189_RS09945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IF189_RS09955	COG2010	Cytochrome c
IF189_RS09960	COG3608	succinylglutamate desuccinylase aspartoacylase
IF189_RS09960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IF189_RS09965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS09990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IF189_RS10025	COG1879	ABC-type sugar transport system periplasmic component
IF189_RS10030	COG1129	ABC transporter
IF189_RS10035	COG1172	Belongs to the binding-protein-dependent transport system permease family
IF189_RS10045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF189_RS10050	COG1869	D-ribose catabolic process
IF189_RS10075	COG1278	Cold shock
IF189_RS10085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IF189_RS10090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IF189_RS10095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IF189_RS10100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IF189_RS10105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IF189_RS10110	COG0072	phenylalanine-tRNA ligase activity
IF189_RS10115	COG0776	regulation of translation
IF189_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS10150	COG3321	synthase
IF189_RS10150	COG0604	alcohol dehydrogenase
IF189_RS10165	COG1741	Belongs to the pirin family
IF189_RS10210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IF189_RS10215	COG1335	isochorismatase
IF189_RS10230	COG0583	DNA-binding transcription factor activity
IF189_RS10240	COG1459	type II secretion system
IF189_RS10250	COG0741	lytic transglycosylase activity
IF189_RS10250	COG0739	heme binding
IF189_RS10250	COG1196	nuclear chromosome segregation
IF189_RS10285	COG0745	RESPONSE REGULATOR receiver
IF189_RS10290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF189_RS10345	COG1462	curli production assembly transport component CsgG
IF189_RS10390	COG5002	protein histidine kinase activity
IF189_RS10405	COG2205	protein histidine kinase activity
IF189_RS10455	COG0726	polysaccharide deacetylase
IF189_RS10475	COG0438	transferase activity, transferring glycosyl groups
IF189_RS10515	COG1136	(ABC) transporter
IF189_RS10540	COG2720	vancomycin resistance protein
IF189_RS10585	COG3209	COG3209 Rhs family protein
IF189_RS10605	COG5383	Protein conserved in bacteria
IF189_RS10610	COG2267	carboxylic ester hydrolase activity
IF189_RS10615	COG2072	flavoprotein involved in K transport
IF189_RS10620	COG3706	GGDEF domain
IF189_RS10635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IF189_RS10650	COG0531	amino acid
IF189_RS10665	COG1335	isochorismatase
IF189_RS10730	COG0583	DNA-binding transcription factor activity
IF189_RS10735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IF189_RS10750	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IF189_RS10755	COG0583	DNA-binding transcription factor activity
IF189_RS10760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IF189_RS10765	COG4106	trans-aconitate 2-methyltransferase activity
IF189_RS10775	COG3220	belongs to the UPF0276 family
IF189_RS10850	COG0579	oxidoreductase
IF189_RS10885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IF189_RS10890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IF189_RS10895	COG2080	2 iron, 2 sulfur cluster binding
IF189_RS10915	COG5507	3-demethylubiquinone-9 3-methyltransferase
IF189_RS10925	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IF189_RS10935	COG1177	transmembrane transport
IF189_RS10940	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS10945	COG3842	ATPase activity
IF189_RS10950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IF189_RS10955	COG0174	glutamine synthetase
IF189_RS10960	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS10965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS10970	COG1396	sequence-specific DNA binding
IF189_RS10970	COG1917	Cupin 2, conserved barrel domain protein
IF189_RS11005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF189_RS11025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS11030	COG0174	glutamine synthetase
IF189_RS11045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IF189_RS11055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IF189_RS11060	COG0583	DNA-binding transcription factor activity
IF189_RS11065	COG0521	Mo-molybdopterin cofactor biosynthetic process
IF189_RS11080	COG3791	Glutathione-dependent formaldehyde-activating
IF189_RS11085	COG0583	DNA-binding transcription factor activity
IF189_RS11110	COG2169	Transcriptional regulator
IF189_RS11110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IF189_RS11130	COG4251	negative regulation of phosphorylation
IF189_RS11135	COG0693	protein deglycase activity
IF189_RS11180	COG3706	GGDEF domain
IF189_RS11215	COG2199	diguanylate cyclase activity
IF189_RS11215	COG2203	Gaf domain
IF189_RS11230	COG4172	Belongs to the ABC transporter superfamily
IF189_RS11235	COG4239	(ABC) transporter, permease
IF189_RS11240	COG4174	ABC transporter (Permease)
IF189_RS11245	COG4166	transmembrane transport
IF189_RS11250	COG4166	transmembrane transport
IF189_RS11255	COG0741	lytic transglycosylase activity
IF189_RS11255	COG1388	LysM domain
IF189_RS11260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IF189_RS11270	COG0328	RNA-DNA hybrid ribonuclease activity
IF189_RS11280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF189_RS11305	COG0431	NADPH-dependent FMN reductase
IF189_RS11320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IF189_RS11325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IF189_RS11330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IF189_RS11355	COG0308	aminopeptidase N
IF189_RS11360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IF189_RS11365	COG4206	TonB-dependent receptor
IF189_RS11385	COG1999	signal sequence binding
IF189_RS11415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS11420	COG1136	(ABC) transporter
IF189_RS11420	COG0577	efflux transmembrane transporter activity
IF189_RS11430	COG0247	lactate metabolic process
IF189_RS11435	COG0277	FAD linked oxidase domain protein
IF189_RS11440	COG0277	FAD linked oxidase domain protein
IF189_RS11445	COG0625	glutathione transferase activity
IF189_RS11460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IF189_RS11465	COG0500	methyltransferase
IF189_RS11470	COG5001	Diguanylate cyclase
IF189_RS11470	COG4251	negative regulation of phosphorylation
IF189_RS11470	COG3706	GGDEF domain
IF189_RS11470	COG2203	Gaf domain
IF189_RS11475	COG1902	pentaerythritol trinitrate reductase activity
IF189_RS11485	COG1309	transcriptional regulator
IF189_RS11490	COG2207	Transcriptional regulator
IF189_RS11495	COG0300	oxidoreductase activity
IF189_RS11500	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IF189_RS11545	COG0300	oxidoreductase activity
IF189_RS11555	COG4566	intracellular signal transduction
IF189_RS11565	COG4191	Histidine kinase
IF189_RS11570	COG0604	alcohol dehydrogenase
IF189_RS11570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IF189_RS11570	COG3321	synthase
IF189_RS11570	COG4221	oxidoreductase activity
IF189_RS11575	COG2271	Major facilitator Superfamily
IF189_RS11580	COG0596	Alpha beta hydrolase
IF189_RS11585	COG0596	Alpha beta hydrolase
IF189_RS11615	COG0753	catalase activity
IF189_RS11620	COG1764	response to oxidative stress
IF189_RS11650	COG3251	PFAM MbtH domain protein
IF189_RS11655	COG2175	clavaminate synthase activity
IF189_RS11680	COG1064	alcohol dehydrogenase
IF189_RS11690	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IF189_RS11710	COG1984	allophanate hydrolase subunit 2
IF189_RS11720	COG1073	alpha beta
IF189_RS11735	COG3158	transport of potassium into the cell
IF189_RS11740	COG0642	Histidine kinase
IF189_RS11765	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IF189_RS11775	COG1944	ATP diphosphatase activity
IF189_RS11780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IF189_RS11790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF189_RS11795	COG1846	Transcriptional regulator
IF189_RS11830	COG3011	Protein conserved in bacteria
IF189_RS11835	COG0604	alcohol dehydrogenase
IF189_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS11835	COG3321	synthase
IF189_RS11870	COG0583	DNA-binding transcription factor activity
IF189_RS11885	COG1335	isochorismatase
IF189_RS11890	COG0714	Associated with various cellular activities
IF189_RS11930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF189_RS11935	COG3938	Belongs to the proline racemase family
IF189_RS11940	COG0531	amino acid
IF189_RS11950	COG2207	Transcriptional regulator
IF189_RS11950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IF189_RS11990	COG1120	ATPase activity
IF189_RS11995	COG4139	cobalamin transport
IF189_RS12005	COG4774	siderophore transport
IF189_RS12010	COG3712	iron ion homeostasis
IF189_RS12015	COG1595	DNA-templated transcription, initiation
IF189_RS12025	COG2814	Major facilitator Superfamily
IF189_RS12030	COG4264	IucA IucC family
IF189_RS12035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IF189_RS12040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IF189_RS12045	COG0019	diaminopimelate decarboxylase activity
IF189_RS12060	COG4774	siderophore transport
IF189_RS12110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IF189_RS12115	COG2011	ABC-type metal ion transport system permease component
IF189_RS12120	COG1129	ABC transporter
IF189_RS12125	COG1172	Belongs to the binding-protein-dependent transport system permease family
IF189_RS12140	COG0531	amino acid
IF189_RS12150	COG1064	alcohol dehydrogenase
IF189_RS12205	COG0583	DNA-binding transcription factor activity
IF189_RS12210	COG0066	3-isopropylmalate dehydratase activity
IF189_RS12215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IF189_RS12220	COG2030	dehydratase
IF189_RS12225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IF189_RS12250	COG0251	oxidation-reduction process
IF189_RS12265	COG0583	DNA-binding transcription factor activity
IF189_RS12270	COG2957	Belongs to the agmatine deiminase family
IF189_RS12285	COG2957	Belongs to the agmatine deiminase family
IF189_RS12295	COG0251	oxidation-reduction process
IF189_RS12305	COG0583	DNA-binding transcription factor activity
IF189_RS12310	COG1473	amidohydrolase
IF189_RS12325	COG2365	Tyrosine phosphatase family
IF189_RS12335	COG0583	DNA-binding transcription factor activity
IF189_RS12350	COG0477	Major facilitator Superfamily
IF189_RS12355	COG1971	Probably functions as a manganese efflux pump
IF189_RS12360	COG0642	Histidine kinase
IF189_RS12395	COG0477	Major facilitator Superfamily
IF189_RS12400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IF189_RS12410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF189_RS12425	COG0826	peptidase U32
IF189_RS12440	COG4638	Rieske (2fe-2S)
IF189_RS12450	COG0583	DNA-binding transcription factor activity
IF189_RS12455	COG4175	Glycine betaine
IF189_RS12460	COG4176	ABC-type proline glycine betaine transport system permease component
IF189_RS12465	COG2113	Glycine betaine
IF189_RS12475	COG2271	Major facilitator Superfamily
IF189_RS12485	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS12525	COG2384	SAM-dependent methyltransferase
IF189_RS12550	COG2207	Transcriptional regulator
IF189_RS12565	COG3268	Saccharopine dehydrogenase
IF189_RS12570	COG3264	Mechanosensitive ion channel
IF189_RS12570	COG1511	domain protein
IF189_RS12585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS12600	COG0431	NADPH-dependent FMN reductase
IF189_RS12605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IF189_RS12610	COG0640	Transcriptional regulator
IF189_RS12625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF189_RS12690	COG0583	DNA-binding transcription factor activity
IF189_RS12695	COG2259	Doxx family
IF189_RS12720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IF189_RS12725	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
IF189_RS12735	COG3046	protein related to deoxyribodipyrimidine photolyase
IF189_RS12790	COG1522	sequence-specific DNA binding
IF189_RS12795	COG0697	spore germination
IF189_RS12835	COG0811	peptide transport
IF189_RS12865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF189_RS12895	COG0456	acetyltransferase
IF189_RS12910	COG3278	Belongs to the heme-copper respiratory oxidase family
IF189_RS12915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF189_RS12935	COG3795	YCII-related domain
IF189_RS12965	COG1538	Outer membrane efflux protein
IF189_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS12980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS12995	COG1285	pathogenesis
IF189_RS13015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IF189_RS13025	COG3568	Endonuclease Exonuclease Phosphatase
IF189_RS13075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IF189_RS13080	COG0297	glycogen (starch) synthase activity
IF189_RS13085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF189_RS13090	COG0596	Alpha beta hydrolase
IF189_RS13095	COG1238	metal cluster binding
IF189_RS13155	COG2366	antibiotic biosynthetic process
IF189_RS13205	COG2233	PERMEase
IF189_RS13220	COG0010	Belongs to the arginase family
IF189_RS13235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IF189_RS13255	COG2194	sulfuric ester hydrolase activity
IF189_RS13265	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IF189_RS13270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IF189_RS13275	COG0561	phosphatase activity
IF189_RS13280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF189_RS13295	COG2204	response regulator
IF189_RS13340	COG0840	transmembrane signaling receptor activity
IF189_RS13345	COG1968	undecaprenyl-diphosphatase activity
IF189_RS13365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IF189_RS13380	COG0488	(ABC) transporter
IF189_RS13390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IF189_RS13400	COG2133	pyrroloquinoline quinone binding
IF189_RS13415	COG0598	Magnesium transport protein CorA
IF189_RS13425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IF189_RS13435	COG4574	serine-type endopeptidase inhibitor activity
IF189_RS13480	COG1070	Carbohydrate kinase
IF189_RS13485	COG0246	Mannitol dehydrogenase
IF189_RS13500	COG1175	transmembrane transport
IF189_RS13525	COG2198	Histidine kinase
IF189_RS13525	COG2205	protein histidine kinase activity
IF189_RS13525	COG0784	Response regulator, receiver
IF189_RS13530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IF189_RS13540	COG2198	Histidine kinase
IF189_RS13540	COG2205	protein histidine kinase activity
IF189_RS13540	COG0784	Response regulator, receiver
IF189_RS13555	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IF189_RS13575	COG1566	PFAM secretion protein HlyD family protein
IF189_RS13610	COG2814	Major facilitator Superfamily
IF189_RS13640	COG3321	synthase
IF189_RS13640	COG0604	alcohol dehydrogenase
IF189_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS13650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS13665	COG0210	DNA helicase
IF189_RS13680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS13730	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IF189_RS13735	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IF189_RS13735	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IF189_RS13755	COG0513	Belongs to the DEAD box helicase family
IF189_RS13770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IF189_RS13780	COG0437	4 iron, 4 sulfur cluster binding
IF189_RS13785	COG2864	formate dehydrogenase
IF189_RS13790	COG3058	Necessary for formate dehydrogenase activity
IF189_RS13795	COG1921	L-seryl-tRNASec selenium transferase activity
IF189_RS13800	COG3276	selenocysteine insertion sequence binding
IF189_RS13850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IF189_RS13860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS13865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF189_RS13880	COG0583	DNA-binding transcription factor activity
IF189_RS13900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IF189_RS13925	COG2885	chlorophyll binding
IF189_RS13935	COG3639	organic phosphonate transmembrane transporter activity
IF189_RS13940	COG3639	organic phosphonate transmembrane transporter activity
IF189_RS13945	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IF189_RS13950	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IF189_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS13965	COG2995	paraquat-inducible protein a
IF189_RS13985	COG0583	DNA-binding transcription factor activity
IF189_RS14010	COG1764	response to oxidative stress
IF189_RS14015	COG1280	lysine exporter protein (LysE YggA)
IF189_RS14025	COG2205	protein histidine kinase activity
IF189_RS14030	COG0745	RESPONSE REGULATOR receiver
IF189_RS14035	COG0745	RESPONSE REGULATOR receiver
IF189_RS14060	COG1132	(ABC) transporter
IF189_RS14100	COG3971	2-oxopent-4-enoate hydratase activity
IF189_RS14155	COG2814	Major facilitator Superfamily
IF189_RS14170	COG3971	2-oxopent-4-enoate hydratase activity
IF189_RS14175	COG2267	carboxylic ester hydrolase activity
IF189_RS14190	COG1414	Transcriptional regulator
IF189_RS14200	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS14215	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IF189_RS14235	COG0531	amino acid
IF189_RS14250	COG2814	Major facilitator Superfamily
IF189_RS14265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS14275	COG1846	Transcriptional regulator
IF189_RS14290	COG3971	2-oxopent-4-enoate hydratase activity
IF189_RS14295	COG2271	Major facilitator Superfamily
IF189_RS14305	COG3384	dioxygenase
IF189_RS14310	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS14330	COG2814	Major facilitator Superfamily
IF189_RS14335	COG1846	Transcriptional regulator
IF189_RS14365	COG0765	amino acid transport
IF189_RS14370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS14385	COG0183	Belongs to the thiolase family
IF189_RS14390	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14395	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14400	COG1024	Enoyl-CoA hydratase
IF189_RS14410	COG1024	Enoyl-CoA hydratase
IF189_RS14415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IF189_RS14425	COG0346	lactoylglutathione lyase activity
IF189_RS14435	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IF189_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS14475	COG1053	succinate dehydrogenase
IF189_RS14490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IF189_RS14500	COG0657	acetylesterase activity
IF189_RS14505	COG4221	oxidoreductase activity
IF189_RS14540	COG0596	Alpha beta hydrolase
IF189_RS14560	COG0183	Belongs to the thiolase family
IF189_RS14575	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14675	COG0174	glutamine synthetase
IF189_RS14685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS14690	COG3008	intermembrane lipid transfer
IF189_RS14700	COG0642	Histidine kinase
IF189_RS14710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IF189_RS14715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IF189_RS14730	COG3842	ATPase activity
IF189_RS14735	COG4974	Belongs to the 'phage' integrase family
IF189_RS14740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IF189_RS14745	COG0463	Glycosyl transferase, family 2
IF189_RS14750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF189_RS14750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IF189_RS14755	COG0726	polysaccharide deacetylase
IF189_RS14760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IF189_RS14765	COG2076	Multidrug Resistance protein
IF189_RS14770	COG2076	Multidrug Resistance protein
IF189_RS14790	COG2814	Major facilitator Superfamily
IF189_RS14800	COG1024	Enoyl-CoA hydratase
IF189_RS14805	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14810	COG1024	Enoyl-CoA hydratase
IF189_RS14815	COG1960	acyl-CoA dehydrogenase activity
IF189_RS14820	COG0183	Belongs to the thiolase family
IF189_RS14830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF189_RS14835	COG2207	Transcriptional regulator
IF189_RS14840	COG0672	)-iron permease
IF189_RS14845	COG2822	iron ion transport
IF189_RS14855	COG2822	iron ion transport
IF189_RS14860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF189_RS14885	COG2816	NAD+ diphosphatase activity
IF189_RS14890	COG1024	Enoyl-CoA hydratase
IF189_RS14905	COG1595	DNA-templated transcription, initiation
IF189_RS14915	COG1335	isochorismatase
IF189_RS14920	COG2205	protein histidine kinase activity
IF189_RS14925	COG0745	RESPONSE REGULATOR receiver
IF189_RS14930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS14955	COG1609	Transcriptional regulator
IF189_RS14965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF189_RS14990	COG1929	Belongs to the glycerate kinase type-1 family
IF189_RS14995	COG3835	regulator
IF189_RS15000	COG2271	Major facilitator Superfamily
IF189_RS15015	COG0583	DNA-binding transcription factor activity
IF189_RS15020	COG0667	Aldo Keto reductase
IF189_RS15025	COG2962	Rard protein
IF189_RS15040	COG0583	DNA-binding transcription factor activity
IF189_RS15045	COG2200	EAL domain
IF189_RS15065	COG3634	alkyl hydroperoxide reductase activity
IF189_RS15130	COG3145	DNA-N1-methyladenine dioxygenase activity
IF189_RS15135	COG2169	Transcriptional regulator
IF189_RS15135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IF189_RS15145	COG0604	alcohol dehydrogenase
IF189_RS15170	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IF189_RS15180	COG0488	(ABC) transporter
IF189_RS15215	COG2755	lipolytic protein G-D-S-L family
IF189_RS15215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IF189_RS15245	COG0322	excinuclease ABC activity
IF189_RS15250	COG2197	response regulator
IF189_RS15260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IF189_RS15270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IF189_RS15275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF189_RS15280	COG4166	transmembrane transport
IF189_RS15285	COG4174	ABC transporter (Permease)
IF189_RS15290	COG4239	(ABC) transporter, permease
IF189_RS15295	COG4172	Belongs to the ABC transporter superfamily
IF189_RS15300	COG3829	transcription factor binding
IF189_RS15300	COG3290	protein histidine kinase activity
IF189_RS15305	COG2610	gluconate transmembrane transporter activity
IF189_RS15310	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS15315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF189_RS15330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF189_RS15335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF189_RS15360	COG0765	amino acid transport
IF189_RS15365	COG0765	amino acid transport
IF189_RS15370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS15380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IF189_RS15385	COG1215	transferase activity, transferring glycosyl groups
IF189_RS15400	COG3706	GGDEF domain
IF189_RS15410	COG1253	flavin adenine dinucleotide binding
IF189_RS15470	COG0316	Belongs to the HesB IscA family
IF189_RS15470	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IF189_RS15475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IF189_RS15510	COG0616	signal peptide processing
IF189_RS15540	COG4172	Belongs to the ABC transporter superfamily
IF189_RS15545	COG4239	(ABC) transporter, permease
IF189_RS15550	COG4174	ABC transporter (Permease)
IF189_RS15555	COG4166	transmembrane transport
IF189_RS15560	COG4206	TonB-dependent receptor
IF189_RS15560	COG4206	TonB-dependent receptor
IF189_RS15575	COG4206	TonB-dependent receptor
IF189_RS15580	COG3712	iron ion homeostasis
IF189_RS15585	COG1595	DNA-templated transcription, initiation
IF189_RS15590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IF189_RS15590	COG1024	Enoyl-CoA hydratase
IF189_RS15625	COG1366	Belongs to the anti-sigma-factor antagonist family
IF189_RS15630	COG1366	Belongs to the anti-sigma-factor antagonist family
IF189_RS15635	COG2172	sigma factor antagonist activity
IF189_RS15645	COG2205	protein histidine kinase activity
IF189_RS15660	COG0784	Response regulator, receiver
IF189_RS15660	COG4191	Histidine kinase
IF189_RS15670	COG3842	ATPase activity
IF189_RS15675	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS15680	COG1177	transmembrane transport
IF189_RS15695	COG1228	amidohydrolase
IF189_RS15700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IF189_RS15720	COG0587	DNA-directed DNA polymerase activity
IF189_RS15735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IF189_RS15770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF189_RS15775	COG4521	taurine ABC transporter
IF189_RS15785	COG2081	HI0933 family
IF189_RS15790	COG2188	Transcriptional regulator
IF189_RS15795	COG0673	inositol 2-dehydrogenase activity
IF189_RS15945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF189_RS15980	COG0714	Associated with various cellular activities
IF189_RS16020	COG3210	domain, Protein
IF189_RS16025	COG0420	3'-5' exonuclease activity
IF189_RS16055	COG2706	6-phosphogluconolactonase activity
IF189_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS16085	COG1609	Transcriptional regulator
IF189_RS16105	COG2267	carboxylic ester hydrolase activity
IF189_RS16110	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS16120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF189_RS16125	COG2186	Transcriptional regulator
IF189_RS16145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF189_RS16155	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS16165	COG3842	ATPase activity
IF189_RS16170	COG0024	Methionine aminopeptidase
IF189_RS16180	COG0248	Ppx GppA phosphatase
IF189_RS16190	COG0626	cystathionine gamma-synthase activity
IF189_RS16230	COG2207	Transcriptional regulator
IF189_RS16235	COG0154	amidase activity
IF189_RS16245	COG0861	Integral membrane protein TerC family
IF189_RS16255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IF189_RS16265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IF189_RS16335	COG2072	flavoprotein involved in K transport
IF189_RS16355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IF189_RS16370	COG0583	DNA-binding transcription factor activity
IF189_RS16375	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS16380	COG0477	Major facilitator Superfamily
IF189_RS16385	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS16390	COG0583	DNA-binding transcription factor activity
IF189_RS16400	COG0247	lactate metabolic process
IF189_RS16400	COG0277	FAD linked oxidase domain protein
IF189_RS16405	COG0583	DNA-binding transcription factor activity
IF189_RS16420	COG4948	Mandelate Racemase Muconate Lactonizing
IF189_RS16430	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS16445	COG0583	DNA-binding transcription factor activity
IF189_RS16450	COG0477	Major facilitator Superfamily
IF189_RS16460	COG0667	Aldo Keto reductase
IF189_RS16475	COG1959	2 iron, 2 sulfur cluster binding
IF189_RS16495	COG0494	nUDIX hydrolase
IF189_RS16510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF189_RS16520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF189_RS16525	COG2135	peptidase activity
IF189_RS16560	COG1611	Belongs to the LOG family
IF189_RS16595	COG2111	Na H antiporter
IF189_RS16595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IF189_RS16600	COG1006	Multisubunit Na H antiporter MnhC subunit
IF189_RS16605	COG0651	ATP synthesis coupled electron transport
IF189_RS16615	COG2212	antiporter activity
IF189_RS16620	COG1320	monovalent cation:proton antiporter activity
IF189_RS16635	COG4774	siderophore transport
IF189_RS16675	COG4335	DNA alkylation repair
IF189_RS16760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IF189_RS16765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IF189_RS16785	COG0583	DNA-binding transcription factor activity
IF189_RS16790	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IF189_RS16800	COG0288	reversible hydration of carbon dioxide
IF189_RS16810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IF189_RS16815	COG2066	Belongs to the glutaminase family
IF189_RS16825	COG2259	Doxx family
IF189_RS16855	COG2814	Major facilitator Superfamily
IF189_RS16880	COG1294	oxidase, subunit
IF189_RS16885	COG1271	oxidase subunit
IF189_RS16895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IF189_RS16900	COG3781	membrane
IF189_RS16905	COG2205	protein histidine kinase activity
IF189_RS16910	COG0745	RESPONSE REGULATOR receiver
IF189_RS16920	COG0589	response to stress
IF189_RS16945	COG0814	amino acid
IF189_RS16960	COG1942	4-Oxalocrotonate Tautomerase
IF189_RS16970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF189_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS17085	COG0583	DNA-binding transcription factor activity
IF189_RS17105	COG3618	amidohydrolase
IF189_RS17115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IF189_RS17125	COG0523	cobalamin synthesis protein
IF189_RS17130	COG2233	PERMEase
IF189_RS17155	COG1953	Uracil, thiamine, allantoin
IF189_RS17165	COG0493	'glutamate synthase
IF189_RS17175	COG1309	transcriptional regulator
IF189_RS17210	COG0730	response to heat
IF189_RS17220	COG0640	Transcriptional regulator
IF189_RS17235	COG1522	sequence-specific DNA binding
IF189_RS17240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IF189_RS17245	COG0022	dehydrogenase e1 component
IF189_RS17255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF189_RS17260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IF189_RS17265	COG0583	DNA-binding transcription factor activity
IF189_RS17285	COG1215	transferase activity, transferring glycosyl groups
IF189_RS17300	COG1230	cation diffusion facilitator family transporter
IF189_RS17360	COG0583	DNA-binding transcription factor activity
IF189_RS17370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS17375	COG0446	pyridine nucleotide-disulphide oxidoreductase
IF189_RS17395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF189_RS17400	COG0745	RESPONSE REGULATOR receiver
IF189_RS17405	COG5002	protein histidine kinase activity
IF189_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS17425	COG0583	DNA-binding transcription factor activity
IF189_RS17430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IF189_RS17440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF189_RS17445	COG2201	protein-glutamate methylesterase activity
IF189_RS17450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF189_RS17470	COG2249	NAD(P)H dehydrogenase (quinone) activity
IF189_RS17510	COG0583	DNA-binding transcription factor activity
IF189_RS17520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IF189_RS17525	COG0534	Mate efflux family protein
IF189_RS17550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS17555	COG0697	spore germination
IF189_RS17570	COG0659	secondary active sulfate transmembrane transporter activity
IF189_RS17595	COG1335	isochorismatase
IF189_RS17610	COG0494	nUDIX hydrolase
IF189_RS17615	COG3469	chitinase activity
IF189_RS17665	COG2920	part of a sulfur-relay system
IF189_RS17670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IF189_RS17675	COG0435	Glutathione S-transferase
IF189_RS17680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IF189_RS17680	COG1648	precorrin-2 dehydrogenase activity
IF189_RS17685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IF189_RS17690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IF189_RS17695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IF189_RS17700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IF189_RS17705	COG1674	ftsk spoiiie
IF189_RS17710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IF189_RS17715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IF189_RS17720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IF189_RS17730	COG0542	response to heat
IF189_RS17735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IF189_RS17740	COG1278	Cold shock
IF189_RS17760	COG0482	sulfurtransferase activity
IF189_RS17765	COG2915	High frequency lysogenization protein hflD homolog
IF189_RS17775	COG2850	peptidyl-arginine hydroxylation
IF189_RS17780	COG2153	protein acetylation
IF189_RS17790	COG2224	Isocitrate lyase
IF189_RS17795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IF189_RS17800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IF189_RS17805	COG0649	NAD binding
IF189_RS17805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IF189_RS17820	COG1034	ATP synthesis coupled electron transport
IF189_RS17825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IF189_RS17830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IF189_RS17840	COG0713	ATP synthesis coupled electron transport
IF189_RS17855	COG1007	ATP synthesis coupled electron transport
IF189_RS17940	COG0395	ABC-type sugar transport system, permease component
IF189_RS17950	COG3842	ATPase activity
IF189_RS17955	COG3842	ATPase activity
IF189_RS17960	COG3284	Transcriptional regulator
IF189_RS17965	COG1968	undecaprenyl-diphosphatase activity
IF189_RS17975	COG0215	cysteine-tRNA ligase activity
IF189_RS17980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF189_RS17990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF189_RS17995	COG2814	Major facilitator Superfamily
IF189_RS18000	COG1566	PFAM secretion protein HlyD family protein
IF189_RS18010	COG1846	Transcriptional regulator
IF189_RS18020	COG2911	Protein conserved in bacteria
IF189_RS18025	COG0729	surface antigen
IF189_RS18035	COG0708	Exodeoxyribonuclease III
IF189_RS18040	COG2885	chlorophyll binding
IF189_RS18045	COG1960	acyl-CoA dehydrogenase activity
IF189_RS18055	COG0789	Transcriptional regulator
IF189_RS18075	COG0318	PFAM AMP-dependent synthetase and ligase
IF189_RS18080	COG1960	acyl-CoA dehydrogenase activity
IF189_RS18085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IF189_RS18090	COG1024	Enoyl-CoA hydratase
IF189_RS18100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IF189_RS18115	COG2866	Carboxypeptidase
IF189_RS18120	COG2814	Major facilitator Superfamily
IF189_RS18125	COG3038	cytochrome b561
IF189_RS18135	COG1595	DNA-templated transcription, initiation
IF189_RS18180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IF189_RS18190	COG0217	transcriptional regulatory protein
IF189_RS18200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS18210	COG0583	DNA-binding transcription factor activity
IF189_RS18215	COG0583	DNA-binding transcription factor activity
IF189_RS18220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IF189_RS18225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF189_RS18230	COG3038	cytochrome b561
IF189_RS18240	COG1902	pentaerythritol trinitrate reductase activity
IF189_RS18240	COG0446	pyridine nucleotide-disulphide oxidoreductase
IF189_RS18265	COG2814	Major facilitator Superfamily
IF189_RS18270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF189_RS18275	COG0776	regulation of translation
IF189_RS18280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IF189_RS18285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IF189_RS18290	COG0740	serine-type endopeptidase activity
IF189_RS18295	COG0544	peptidyl-prolyl cis-trans isomerase activity
IF189_RS18320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IF189_RS18325	COG1686	Belongs to the peptidase S11 family
IF189_RS18345	COG1253	flavin adenine dinucleotide binding
IF189_RS18355	COG0583	DNA-binding transcription factor activity
IF189_RS18365	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IF189_RS18375	COG3132	Protein of unknown function, DUF480
IF189_RS18385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IF189_RS18405	COG0628	permease
IF189_RS18410	COG0826	peptidase U32
IF189_RS18415	COG0583	DNA-binding transcription factor activity
IF189_RS18420	COG0697	spore germination
IF189_RS18425	COG1609	Transcriptional regulator
IF189_RS18460	COG2197	response regulator
IF189_RS18480	COG0730	response to heat
IF189_RS18485	COG2814	Major facilitator Superfamily
IF189_RS18530	COG0656	L-ascorbic acid biosynthetic process
IF189_RS18540	COG0417	DNA replication proofreading
IF189_RS18545	COG0517	IMP dehydrogenase activity
IF189_RS18565	COG0113	porphobilinogen synthase activity
IF189_RS18570	COG0625	glutathione transferase activity
IF189_RS18580	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IF189_RS18605	COG1063	alcohol dehydrogenase
IF189_RS18660	COG2056	Na+-H+ antiporter family
IF189_RS18665	COG0840	transmembrane signaling receptor activity
IF189_RS18695	COG0720	synthase
IF189_RS18705	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IF189_RS18710	COG0402	S-adenosylhomocysteine deaminase activity
IF189_RS18720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IF189_RS18725	COG2223	nitrite transmembrane transporter activity
IF189_RS18730	COG4772	TonB-dependent receptor
IF189_RS18740	COG1595	DNA-templated transcription, initiation
IF189_RS18755	COG2226	methyltransferase
IF189_RS18760	COG4638	Rieske (2fe-2S)
IF189_RS18790	COG2814	Major facilitator Superfamily
IF189_RS18810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF189_RS18815	COG1595	DNA-templated transcription, initiation
IF189_RS18820	COG3712	iron ion homeostasis
IF189_RS18835	COG2203	Gaf domain
IF189_RS18835	COG5001	Diguanylate cyclase
IF189_RS18835	COG4251	negative regulation of phosphorylation
IF189_RS18835	COG3706	GGDEF domain
IF189_RS18915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IF189_RS18925	COG1968	undecaprenyl-diphosphatase activity
IF189_RS18940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IF189_RS18945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF189_RS18970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IF189_RS19030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IF189_RS19040	COG2204	response regulator
IF189_RS19060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IF189_RS19060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IF189_RS19080	COG4591	ABC-type transport system involved in lipoprotein release permease component
IF189_RS19085	COG1136	(ABC) transporter
IF189_RS19090	COG4591	ABC-type transport system involved in lipoprotein release permease component
IF189_RS19100	COG0584	glycerophosphoryl diester phosphodiesterase
IF189_RS19105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF189_RS19110	COG1477	protein flavinylation
IF189_RS19125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IF189_RS19135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IF189_RS19140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IF189_RS19185	COG0183	Belongs to the thiolase family
IF189_RS19190	COG1024	Enoyl-CoA hydratase
IF189_RS19190	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF189_RS19200	COG0589	response to stress
IF189_RS19205	COG0488	(ABC) transporter
IF189_RS19210	COG0741	lytic transglycosylase activity
IF189_RS19220	COG1132	(ABC) transporter
IF189_RS19230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF189_RS19240	COG0425	Belongs to the sulfur carrier protein TusA family
IF189_RS19245	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IF189_RS19265	COG3755	Protein conserved in bacteria
IF189_RS19310	COG1404	Belongs to the peptidase S8 family
IF189_RS19315	COG1132	(ABC) transporter
IF189_RS19335	COG0477	Major facilitator Superfamily
IF189_RS19340	COG0583	DNA-binding transcription factor activity
IF189_RS19345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF189_RS19350	COG0235	Class ii aldolase
IF189_RS19355	COG0477	Major facilitator Superfamily
IF189_RS19360	COG0583	DNA-binding transcription factor activity
IF189_RS19365	COG0768	penicillin binding
IF189_RS19400	COG5006	permease, DMT superfamily
IF189_RS19415	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS19430	COG0583	DNA-binding transcription factor activity
IF189_RS19455	COG0431	NADPH-dependent FMN reductase
IF189_RS19460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IF189_RS19470	COG3829	transcription factor binding
IF189_RS19490	COG2011	ABC-type metal ion transport system permease component
IF189_RS19505	COG0596	Alpha beta hydrolase
IF189_RS19535	COG1121	(ABC) transporter
IF189_RS19540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IF189_RS19565	COG0642	Histidine kinase
IF189_RS19585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IF189_RS19635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IF189_RS19640	COG1960	acyl-CoA dehydrogenase activity
IF189_RS19645	COG1024	Enoyl-CoA hydratase
IF189_RS19645	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF189_RS19660	COG3123	guanosine phosphorylase activity
IF189_RS19680	COG3851	Histidine kinase
IF189_RS19685	COG2197	response regulator
IF189_RS19690	COG1597	lipid kinase activity
IF189_RS19700	COG0303	'Molybdopterin
IF189_RS19705	COG0521	Mo-molybdopterin cofactor biosynthetic process
IF189_RS19710	COG0746	molybdenum cofactor guanylyltransferase activity
IF189_RS19720	COG0564	pseudouridine synthase activity
IF189_RS19740	COG0004	ammonium transporteR
IF189_RS19760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IF189_RS19770	COG2197	response regulator
IF189_RS19775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS19775	COG2205	protein histidine kinase activity
IF189_RS19780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IF189_RS19785	COG1956	GAF domain-containing protein
IF189_RS19795	COG5002	protein histidine kinase activity
IF189_RS19795	COG0784	Response regulator, receiver
IF189_RS19795	COG2205	protein histidine kinase activity
IF189_RS19800	COG1846	Transcriptional regulator
IF189_RS19805	COG0386	Belongs to the glutathione peroxidase family
IF189_RS19810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF189_RS19815	COG0436	Aminotransferase
IF189_RS19820	COG0501	Belongs to the peptidase M48B family
IF189_RS19825	COG0500	methyltransferase
IF189_RS19830	COG3384	dioxygenase
IF189_RS19840	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF189_RS19840	COG1024	Enoyl-CoA hydratase
IF189_RS19850	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IF189_RS19855	COG3214	Protein conserved in bacteria
IF189_RS19865	COG0583	DNA-binding transcription factor activity
IF189_RS19875	COG0583	DNA-binding transcription factor activity
IF189_RS19880	COG1846	Transcriptional regulator
IF189_RS19885	COG1764	response to oxidative stress
IF189_RS19890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IF189_RS19905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF189_RS19925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IF189_RS19955	COG1376	ErfK ybiS ycfS ynhG family protein
IF189_RS19970	COG4181	ATPase activity
IF189_RS19975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IF189_RS19990	COG2259	Doxx family
IF189_RS19995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IF189_RS20040	COG2205	protein histidine kinase activity
IF189_RS20045	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IF189_RS20055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IF189_RS20080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF189_RS20085	COG4221	oxidoreductase activity
IF189_RS20090	COG1555	photosystem II stabilization
IF189_RS20110	COG0463	Glycosyl transferase, family 2
IF189_RS20125	COG1442	glycosyl transferase family 8
IF189_RS20125	COG1216	Glycosyl transferase, family 2
IF189_RS20140	COG2755	lipolytic protein G-D-S-L family
IF189_RS20140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IF189_RS20145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IF189_RS20160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IF189_RS20180	COG0776	regulation of translation
IF189_RS20195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IF189_RS20200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IF189_RS20205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IF189_RS20215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IF189_RS20225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IF189_RS20230	COG0402	S-adenosylhomocysteine deaminase activity
IF189_RS20235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF189_RS20240	COG0546	phosphoglycolate phosphatase activity
IF189_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS20260	COG5002	protein histidine kinase activity
IF189_RS20260	COG5001	Diguanylate cyclase
IF189_RS20280	COG1054	Belongs to the UPF0176 family
IF189_RS20285	COG0271	Belongs to the BolA IbaG family
IF189_RS20295	COG0114	fumarate hydratase activity
IF189_RS20300	COG0697	spore germination
IF189_RS20310	COG0183	Belongs to the thiolase family
IF189_RS20315	COG2326	polyphosphate kinase activity
IF189_RS20320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IF189_RS20320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS20330	COG0367	asparagine synthase
IF189_RS20335	COG0189	ligase activity
IF189_RS20335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IF189_RS20345	COG3089	Belongs to the UPF0270 family
IF189_RS20350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IF189_RS20355	COG1742	UPF0060 membrane protein
IF189_RS20370	COG1368	sulfuric ester hydrolase activity
IF189_RS20390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS20395	COG2885	chlorophyll binding
IF189_RS20425	COG2207	Transcriptional regulator
IF189_RS20430	COG1064	alcohol dehydrogenase
IF189_RS20435	COG1414	Transcriptional regulator
IF189_RS20440	COG2271	Major facilitator Superfamily
IF189_RS20445	COG4948	Mandelate Racemase Muconate Lactonizing
IF189_RS20450	COG0800	Aldolase
IF189_RS20455	COG3734	2-keto-3-deoxy-galactonokinase
IF189_RS20465	COG1418	mRNA catabolic process
IF189_RS20480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF189_RS20490	COG1397	ADP-ribosylglycohydrolase
IF189_RS20495	COG2188	Transcriptional regulator
IF189_RS20500	COG1172	Belongs to the binding-protein-dependent transport system permease family
IF189_RS20505	COG1129	ABC transporter
IF189_RS20510	COG1879	ABC-type sugar transport system periplasmic component
IF189_RS20515	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS20525	COG2186	Transcriptional regulator
IF189_RS20540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IF189_RS20550	COG0084	hydrolase, TatD family'
IF189_RS20565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IF189_RS20570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IF189_RS20580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF189_RS20585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF189_RS20600	COG0416	fatty acid biosynthetic process
IF189_RS20605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IF189_RS20610	COG1399	metal-binding, possibly nucleic acid-binding protein
IF189_RS20615	COG0424	maF-like protein
IF189_RS20620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF189_RS20620	COG0616	signal peptide processing
IF189_RS20625	COG0546	phosphoglycolate phosphatase activity
IF189_RS20635	COG1530	ribonuclease E activity
IF189_RS20645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IF189_RS20645	COG3608	succinylglutamate desuccinylase aspartoacylase
IF189_RS20660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IF189_RS20665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IF189_RS20670	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IF189_RS20675	COG2835	tetraacyldisaccharide 4'-kinase activity
IF189_RS20680	COG1663	tetraacyldisaccharide 4'-kinase activity
IF189_RS20685	COG0848	biopolymer transport protein
IF189_RS20690	COG0811	peptide transport
IF189_RS20705	COG0842	Transport permease protein
IF189_RS20710	COG1131	(ABC) transporter
IF189_RS20715	COG0625	glutathione transferase activity
IF189_RS20725	COG1960	acyl-CoA dehydrogenase activity
IF189_RS20740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IF189_RS20765	COG0534	Mate efflux family protein
IF189_RS20805	COG0840	transmembrane signaling receptor activity
IF189_RS20810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS20815	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS20820	COG2130	NADP-dependent
IF189_RS20825	COG0284	orotidine-5'-phosphate decarboxylase activity
IF189_RS20845	COG0628	permease
IF189_RS20870	COG1022	Amp-dependent synthetase and ligase
IF189_RS20885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IF189_RS20890	COG4771	TonB-dependent receptor
IF189_RS20900	COG2205	protein histidine kinase activity
IF189_RS20900	COG5002	protein histidine kinase activity
IF189_RS20900	COG0784	Response regulator, receiver
IF189_RS20905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF189_RS20920	COG3122	Protein conserved in bacteria
IF189_RS20925	COG3956	TIGRFAM MazG family protein
IF189_RS20930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF189_RS20935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IF189_RS20960	COG0784	Response regulator, receiver
IF189_RS20960	COG2205	protein histidine kinase activity
IF189_RS20960	COG5002	protein histidine kinase activity
IF189_RS20965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF189_RS20985	COG3118	belongs to the thioredoxin family
IF189_RS20990	COG1393	Belongs to the ArsC family
IF189_RS21005	COG2818	Glycosylase
IF189_RS21010	COG0037	tRNA processing
IF189_RS21020	COG3091	SprT-like family
IF189_RS21025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IF189_RS21030	COG1301	dicarboxylic acid transport
IF189_RS21035	COG4977	sequence-specific DNA binding
IF189_RS21035	COG1917	Cupin 2, conserved barrel domain protein
IF189_RS21065	COG2205	protein histidine kinase activity
IF189_RS21070	COG0745	RESPONSE REGULATOR receiver
IF189_RS21075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF189_RS21075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IF189_RS21080	COG1749	Flagellar hook protein flgE
IF189_RS21085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IF189_RS21095	COG1815	bacterial-type flagellum-dependent cell motility
IF189_RS21100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IF189_RS21105	COG0784	Response regulator, receiver
IF189_RS21105	COG0835	chemotaxis
IF189_RS21115	COG2747	anti-sigma28 factor FlgM
IF189_RS21125	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IF189_RS21130	COG0477	Major facilitator Superfamily
IF189_RS21205	COG2239	Acts as a magnesium transporter
IF189_RS21235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IF189_RS21240	COG0527	aspartate kinase activity
IF189_RS21245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IF189_RS21250	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IF189_RS21255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IF189_RS21260	COG2988	succinylglutamate desuccinylase activity
IF189_RS21270	COG3724	N-succinylarginine dihydrolase activity
IF189_RS21275	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS21290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IF189_RS21330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF189_RS21340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF189_RS21410	COG3706	GGDEF domain
IF189_RS21430	COG0504	CTP synthase activity
IF189_RS21435	COG2329	Antibiotic biosynthesis monooxygenase
IF189_RS21445	COG0584	glycerophosphoryl diester phosphodiesterase
IF189_RS21480	COG0306	phosphate transporter
IF189_RS21485	COG0583	DNA-binding transcription factor activity
IF189_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS21500	COG0583	DNA-binding transcription factor activity
IF189_RS21505	COG0583	DNA-binding transcription factor activity
IF189_RS21510	COG4221	oxidoreductase activity
IF189_RS21515	COG4941	Belongs to the sigma-70 factor family
IF189_RS21520	COG3795	YCII-related domain
IF189_RS21530	COG0456	acetyltransferase
IF189_RS21555	COG0436	Aminotransferase
IF189_RS21565	COG3265	gluconokinase activity
IF189_RS21570	COG1609	Transcriptional regulator
IF189_RS21575	COG0583	DNA-binding transcription factor activity
IF189_RS21585	COG2271	Major facilitator Superfamily
IF189_RS21625	COG0242	peptide deformylase activity
IF189_RS21630	COG1295	ribonuclease BN
IF189_RS21645	COG0318	PFAM AMP-dependent synthetase and ligase
IF189_RS21660	COG2030	dehydratase
IF189_RS21670	COG3530	Putative quorum-sensing-regulated virulence factor
IF189_RS21685	COG0800	Aldolase
IF189_RS21700	COG1737	Transcriptional regulator
IF189_RS21705	COG0676	glucose-6-phosphate 1-epimerase activity
IF189_RS21715	COG3842	ATPase activity
IF189_RS21720	COG0395	ABC-type sugar transport system, permease component
IF189_RS21725	COG1175	transmembrane transport
IF189_RS21730	COG1653	transport
IF189_RS21770	COG3712	iron ion homeostasis
IF189_RS21775	COG4771	TonB-dependent receptor
IF189_RS21785	COG2832	Protein of unknown function (DUF454)
IF189_RS21790	COG0840	transmembrane signaling receptor activity
IF189_RS21795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IF189_RS21815	COG2235	arginine
IF189_RS21820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IF189_RS21840	COG0509	glycine decarboxylation via glycine cleavage system
IF189_RS21845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF189_RS21845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF189_RS21850	COG1760	l-serine dehydratase
IF189_RS21855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IF189_RS21860	COG1278	Cold shock
IF189_RS21870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IF189_RS21880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IF189_RS21885	COG0602	queuosine metabolic process
IF189_RS21890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IF189_RS21895	COG2885	chlorophyll binding
IF189_RS21900	COG0823	Involved in the tonB-independent uptake of proteins
IF189_RS21920	COG0824	Thioesterase
IF189_RS21925	COG2255	four-way junction helicase activity
IF189_RS21930	COG0632	four-way junction helicase activity
IF189_RS21935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IF189_RS21940	COG0217	transcriptional regulatory protein
IF189_RS21945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IF189_RS21960	COG0783	Belongs to the Dps family
IF189_RS21970	COG2900	Belongs to the SlyX family
IF189_RS21985	COG0668	transmembrane transport
IF189_RS21990	COG1666	GTP binding
IF189_RS22005	COG2096	Adenosyltransferase
IF189_RS22010	COG0494	nUDIX hydrolase
IF189_RS22020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IF189_RS22025	COG0653	protein targeting
IF189_RS22035	COG0433	COG0433 Predicted ATPase
IF189_RS22065	COG2925	Exonuclease
IF189_RS22090	COG0714	Associated with various cellular activities
IF189_RS22140	COG0469	pyruvate kinase activity
IF189_RS22145	COG1024	Enoyl-CoA hydratase
IF189_RS22155	COG3706	GGDEF domain
IF189_RS22175	COG4191	Histidine kinase
IF189_RS22185	COG0477	Major facilitator Superfamily
IF189_RS22215	COG2207	Transcriptional regulator
IF189_RS22220	COG3842	ATPase activity
IF189_RS22240	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS22250	COG0583	DNA-binding transcription factor activity
IF189_RS22255	COG2910	NAD(P)H-binding
IF189_RS22265	COG0583	DNA-binding transcription factor activity
IF189_RS22285	COG0477	Major facilitator Superfamily
IF189_RS22300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF189_RS22305	COG0583	DNA-binding transcription factor activity
IF189_RS22320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IF189_RS22350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF189_RS22355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF189_RS22365	COG3642	lipopolysaccharide core region biosynthetic process
IF189_RS22375	COG0642	Histidine kinase
IF189_RS22385	COG1368	sulfuric ester hydrolase activity
IF189_RS22395	COG0459	protein refolding
IF189_RS22400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IF189_RS22405	COG3030	protein affecting phage T7 exclusion by the F plasmid
IF189_RS22415	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS22420	COG0489	protein tyrosine kinase activity
IF189_RS22425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF189_RS22425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF189_RS22435	COG2878	Part of a membrane complex involved in electron transport
IF189_RS22440	COG4658	electron transport chain
IF189_RS22445	COG4659	FMN binding
IF189_RS22450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IF189_RS22470	COG0137	argininosuccinate synthase activity
IF189_RS22480	COG0418	dihydroorotase activity
IF189_RS22485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF189_RS22490	COG0450	alkyl hydroperoxide reductase
IF189_RS22505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IF189_RS22510	COG0243	molybdopterin cofactor binding
IF189_RS22520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IF189_RS22525	COG3842	ATPase activity
IF189_RS22535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IF189_RS22545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IF189_RS22560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS22565	COG0765	amino acid transport
IF189_RS22570	COG0765	amino acid transport
IF189_RS22575	COG1126	abc transporter atp-binding protein
IF189_RS22605	COG2076	Multidrug Resistance protein
IF189_RS22620	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IF189_RS22625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IF189_RS22640	COG4191	Histidine kinase
IF189_RS22645	COG2204	response regulator
IF189_RS22655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IF189_RS22665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IF189_RS22670	COG0583	DNA-binding transcription factor activity
IF189_RS22680	COG1280	lysine exporter protein (LysE YggA)
IF189_RS22685	COG0494	nUDIX hydrolase
IF189_RS22705	COG1858	cytochrome C peroxidase
IF189_RS22720	COG0531	amino acid
IF189_RS22730	COG2197	response regulator
IF189_RS22735	COG0069	glutamate synthase activity
IF189_RS22745	COG1113	amino acid transport
IF189_RS22795	COG1695	Transcriptional regulator
IF189_RS22800	COG2375	cellular response to nickel ion
IF189_RS22810	COG4628	conserved protein (DUF2132)
IF189_RS22835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IF189_RS22850	COG4106	trans-aconitate 2-methyltransferase activity
IF189_RS22855	COG0500	methyltransferase
IF189_RS22860	COG0590	tRNA wobble adenosine to inosine editing
IF189_RS22875	COG0519	Catalyzes the synthesis of GMP from XMP
IF189_RS22875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IF189_RS22895	COG0583	DNA-binding transcription factor activity
IF189_RS22900	COG1570	exodeoxyribonuclease VII activity
IF189_RS22905	COG0739	heme binding
IF189_RS22910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IF189_RS22915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IF189_RS22920	COG0436	Aminotransferase
IF189_RS22925	COG1160	GTP binding
IF189_RS22940	COG0124	histidyl-tRNA synthetase
IF189_RS22945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IF189_RS22960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IF189_RS22965	COG0105	UTP biosynthetic process
IF189_RS22975	COG0633	Ferredoxin
IF189_RS22980	COG0443	Heat shock 70 kDa protein
IF189_RS22985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IF189_RS22990	COG0316	Belongs to the HesB IscA family
IF189_RS23000	COG1104	cysteine desulfurase activity
IF189_RS23025	COG3134	Outer membrane lipoprotein
IF189_RS23040	COG1862	Preprotein translocase
IF189_RS23045	COG0343	queuine tRNA-ribosyltransferase activity
IF189_RS23050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IF189_RS23100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IF189_RS23105	COG0583	DNA-binding transcription factor activity
IF189_RS23120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF189_RS23135	COG0745	RESPONSE REGULATOR receiver
IF189_RS23160	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IF189_RS23165	COG0109	protoheme IX farnesyltransferase activity
IF189_RS23175	COG1845	cytochrome c oxidase, subunit III
IF189_RS23180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IF189_RS23185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IF189_RS23190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IF189_RS23200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF189_RS23200	COG1017	nitric oxide dioxygenase activity
IF189_RS23205	COG3604	Transcriptional regulator
IF189_RS23260	COG5002	protein histidine kinase activity
IF189_RS23275	COG4251	negative regulation of phosphorylation
IF189_RS23275	COG3706	GGDEF domain
IF189_RS23275	COG2203	Gaf domain
IF189_RS23275	COG5001	Diguanylate cyclase
IF189_RS23280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IF189_RS23285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IF189_RS23300	COG1181	Belongs to the D-alanine--D-alanine ligase family
IF189_RS23305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IF189_RS23310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IF189_RS23315	COG0772	Belongs to the SEDS family
IF189_RS23320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IF189_RS23325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IF189_RS23330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IF189_RS23335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IF189_RS23350	COG0275	rRNA processing
IF189_RS23355	COG2001	Belongs to the MraZ family
IF189_RS23375	COG0792	nuclease activity
IF189_RS23380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IF189_RS23385	COG2823	Periplasmic or secreted lipoprotein
IF189_RS23390	COG2969	positive regulation of protein catabolic process
IF189_RS23395	COG0625	glutathione transferase activity
IF189_RS23400	COG2857	Cytochrome c1
IF189_RS23405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IF189_RS23410	COG0723	plastoquinol--plastocyanin reductase activity
IF189_RS23415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IF189_RS23420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IF189_RS23425	COG0667	Aldo Keto reductase
IF189_RS23430	COG1960	acyl-CoA dehydrogenase activity
IF189_RS23440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IF189_RS23445	COG0180	Tryptophanyl-tRNA synthetase
IF189_RS23465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IF189_RS23490	COG0318	PFAM AMP-dependent synthetase and ligase
IF189_RS23495	COG2814	Major facilitator Superfamily
IF189_RS23505	COG1280	lysine exporter protein (LysE YggA)
IF189_RS23510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF189_RS23515	COG2813	Specifically methylates the guanine in position
IF189_RS23520	COG2119	membrane
IF189_RS23525	COG0501	Belongs to the peptidase M48B family
IF189_RS23530	COG0840	transmembrane signaling receptor activity
IF189_RS23535	COG2135	peptidase activity
IF189_RS23590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IF189_RS23595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IF189_RS23605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IF189_RS23610	COG1090	epimerase
IF189_RS23615	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IF189_RS23630	COG0789	Transcriptional regulator
IF189_RS23635	COG0415	Belongs to the DNA photolyase family
IF189_RS23645	COG4221	oxidoreductase activity
IF189_RS23660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IF189_RS23680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IF189_RS23685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IF189_RS23695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IF189_RS23700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IF189_RS23710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IF189_RS23715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IF189_RS23725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IF189_RS23730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IF189_RS23735	COG0193	aminoacyl-tRNA hydrolase activity
IF189_RS23745	COG2223	nitrite transmembrane transporter activity
IF189_RS23755	COG0583	DNA-binding transcription factor activity
IF189_RS23760	COG3842	ATPase activity
IF189_RS23765	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS23770	COG1177	transmembrane transport
IF189_RS23780	COG0154	amidase activity
IF189_RS23810	COG0405	Gamma-glutamyltransferase
IF189_RS23830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IF189_RS23845	COG0477	Major facilitator Superfamily
IF189_RS23880	COG0288	reversible hydration of carbon dioxide
IF189_RS23890	COG0456	acetyltransferase
IF189_RS23915	COG3008	intermembrane lipid transfer
IF189_RS23920	COG2995	paraquat-inducible protein a
IF189_RS23925	COG2995	paraquat-inducible protein a
IF189_RS23955	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IF189_RS23960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IF189_RS23965	COG1183	phosphatidylcholine synthase activity
IF189_RS23970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IF189_RS23980	COG0028	Belongs to the TPP enzyme family
IF189_RS24000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IF189_RS24030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IF189_RS24035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF189_RS24040	COG4558	Periplasmic binding protein
IF189_RS24050	COG1489	DNA binding
IF189_RS24055	COG0436	Aminotransferase
IF189_RS24060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IF189_RS24065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF189_RS24075	COG4191	Histidine kinase
IF189_RS24095	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IF189_RS24100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IF189_RS24105	COG0166	Belongs to the GPI family
IF189_RS24110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF189_RS24120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF189_RS24135	COG2823	Periplasmic or secreted lipoprotein
IF189_RS24155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IF189_RS24160	COG0237	dephospho-CoA kinase activity
IF189_RS24165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IF189_RS24190	COG1252	NADH dehydrogenase
IF189_RS24225	COG0542	response to heat
IF189_RS24260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS24300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IF189_RS24305	COG1047	Peptidyl-prolyl cis-trans
IF189_RS24310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IF189_RS24315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IF189_RS24320	COG0196	riboflavin kinase activity
IF189_RS24330	COG0268	Binds directly to 16S ribosomal RNA
IF189_RS24340	COG3045	CreA protein
IF189_RS24345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IF189_RS24350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IF189_RS24355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IF189_RS24360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IF189_RS24365	COG0142	geranyltranstransferase activity
IF189_RS24370	COG2824	Alkylphosphonate utilization operon protein PhnA
IF189_RS24375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IF189_RS24380	COG0545	Peptidyl-prolyl cis-trans isomerase
IF189_RS24390	COG2862	Uncharacterized protein family, UPF0114
IF189_RS24405	COG1067	ATP-dependent peptidase activity
IF189_RS24425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF189_RS24435	COG0488	(ABC) transporter
IF189_RS24445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF189_RS24465	COG0523	cobalamin synthesis protein
IF189_RS24470	COG2879	small protein
IF189_RS24475	COG1966	Carbon starvation protein
IF189_RS24495	COG1970	mechanosensitive ion channel activity
IF189_RS24510	COG2813	Specifically methylates the guanine in position
IF189_RS24520	COG1294	oxidase, subunit
IF189_RS24525	COG1271	oxidase subunit
IF189_RS24555	COG2252	PERMEase
IF189_RS24560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IF189_RS24575	COG0583	DNA-binding transcription factor activity
IF189_RS24580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IF189_RS24585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IF189_RS24590	COG1309	transcriptional regulator
IF189_RS24595	COG1082	Xylose isomerase domain protein TIM barrel
IF189_RS24595	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IF189_RS24600	COG0477	Major facilitator Superfamily
IF189_RS24615	COG0656	L-ascorbic acid biosynthetic process
IF189_RS24620	COG2321	neutral zinc metallopeptidase
IF189_RS24635	COG1946	Acyl-CoA thioesterase
IF189_RS24645	COG0123	including yeast histone deacetylase and acetoin utilization protein
IF189_RS24655	COG0513	Belongs to the DEAD box helicase family
IF189_RS24660	COG0697	spore germination
IF189_RS24665	COG1522	sequence-specific DNA binding
IF189_RS24670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF189_RS24670	COG1199	ATP-dependent helicase activity
IF189_RS24680	COG3416	Protein conserved in bacteria
IF189_RS24715	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS24720	COG0583	DNA-binding transcription factor activity
IF189_RS24725	COG1643	Atp-dependent helicase
IF189_RS24735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IF189_RS24745	COG1522	sequence-specific DNA binding
IF189_RS24760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IF189_RS24765	COG1960	acyl-CoA dehydrogenase activity
IF189_RS24770	COG0784	Response regulator, receiver
IF189_RS24770	COG2205	protein histidine kinase activity
IF189_RS24770	COG2198	Histidine kinase
IF189_RS24780	COG0352	thiamine-phosphate diphosphorylase activity
IF189_RS24785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IF189_RS24800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IF189_RS24805	COG1702	phosphate starvation-inducible protein PhoH
IF189_RS24810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IF189_RS24815	COG4535	Mg2 and Co2 transporter CorC
IF189_RS24820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IF189_RS24835	COG0495	leucyl-tRNA aminoacylation
IF189_RS24855	COG2951	lytic endotransglycosylase activity
IF189_RS24865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IF189_RS24870	COG0321	lipoyl(octanoyl) transferase activity
IF189_RS24875	COG2921	Belongs to the UPF0250 family
IF189_RS24880	COG1686	Belongs to the peptidase S11 family
IF189_RS24890	COG2951	lytic endotransglycosylase activity
IF189_RS24895	COG0772	Belongs to the SEDS family
IF189_RS24900	COG0768	penicillin binding
IF189_RS24905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IF189_RS24915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IF189_RS24920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IF189_RS24925	COG2094	Belongs to the DNA glycosylase MPG family
IF189_RS24930	COG0586	Pfam SNARE associated Golgi protein
IF189_RS24950	COG1346	cytolysis
IF189_RS24970	COG0702	epimerase
IF189_RS24990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IF189_RS24995	COG3284	Transcriptional regulator
IF189_RS25010	COG4303	Ethanolamine ammonia lyase large subunit
IF189_RS25015	COG4302	ethanolamine ammonia-lyase activity
IF189_RS25020	COG0456	acetyltransferase
IF189_RS25025	COG0586	Pfam SNARE associated Golgi protein
IF189_RS25030	COG3228	Belongs to the MtfA family
IF189_RS25035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IF189_RS25045	COG4676	Protein conserved in bacteria
IF189_RS25050	COG5445	Predicted secreted protein (DUF2300)
IF189_RS25065	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
IF189_RS25070	COG4676	Protein conserved in bacteria
IF189_RS25080	COG1722	exodeoxyribonuclease VII activity
IF189_RS25085	COG0142	geranyltranstransferase activity
IF189_RS25090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IF189_RS25095	COG4206	TonB-dependent receptor
IF189_RS25100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IF189_RS25110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF189_RS25120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IF189_RS25125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IF189_RS25130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IF189_RS25135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IF189_RS25150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF189_RS25150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF189_RS25155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IF189_RS25165	COG2264	protein methyltransferase activity
IF189_RS25170	COG3118	belongs to the thioredoxin family
IF189_RS25200	COG3047	cAMP biosynthetic process
IF189_RS25205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF189_RS25215	COG1201	RNA secondary structure unwinding
IF189_RS25220	COG0668	transmembrane transport
IF189_RS25225	COG2814	Major facilitator Superfamily
IF189_RS25230	COG3568	Endonuclease Exonuclease Phosphatase
IF189_RS25235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF189_RS25240	COG0392	lysyltransferase activity
IF189_RS25255	COG2207	Transcriptional regulator
IF189_RS25255	COG4753	response regulator
IF189_RS25260	COG1335	isochorismatase
IF189_RS25265	COG3789	protein conserved in bacteria
IF189_RS25270	COG1842	Phage shock protein A
IF189_RS25280	COG3766	membrane
IF189_RS25290	COG0754	glutathionylspermidine amidase activity
IF189_RS25295	COG2755	lipolytic protein G-D-S-L family
IF189_RS25295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IF189_RS25300	COG0629	single-stranded DNA binding
IF189_RS25305	COG2814	Major facilitator Superfamily
IF189_RS25310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IF189_RS25315	COG2193	ferroxidase activity
IF189_RS25325	COG0203	ribosomal protein L17
IF189_RS25330	COG0202	RNA polymerase activity
IF189_RS25335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IF189_RS25340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IF189_RS25345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IF189_RS25350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IF189_RS25360	COG0200	Binds to the 23S rRNA
IF189_RS25365	COG1841	ribosomal large subunit assembly
IF189_RS25370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IF189_RS25375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IF189_RS25380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IF189_RS25385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IF189_RS25390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IF189_RS25395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IF189_RS25400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IF189_RS25405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IF189_RS25410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IF189_RS25415	COG0255	Belongs to the universal ribosomal protein uL29 family
IF189_RS25420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IF189_RS25425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IF189_RS25430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IF189_RS25435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IF189_RS25440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IF189_RS25445	COG0089	rRNA binding
IF189_RS25450	COG0088	Forms part of the polypeptide exit tunnel
IF189_RS25455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IF189_RS25460	COG0051	transcription antitermination factor activity, RNA binding
IF189_RS25465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IF189_RS25470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IF189_RS25475	COG0049	tRNA binding
IF189_RS25480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IF189_RS25485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IF189_RS25490	COG0085	RNA polymerase activity
IF189_RS25495	COG0222	ribosome binding
IF189_RS25500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IF189_RS25505	COG0081	regulation of translation
IF189_RS25510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IF189_RS25530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IF189_RS25555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IF189_RS25590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IF189_RS25595	COG0739	heme binding
IF189_RS25600	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IF189_RS25605	COG0316	Belongs to the HesB IscA family
IF189_RS25610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IF189_RS25615	COG1981	membrane
IF189_RS25630	COG4221	oxidoreductase activity
IF189_RS25635	COG0537	adenosine 5'-monophosphoramidase activity
IF189_RS25640	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IF189_RS25645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IF189_RS25650	COG1765	OsmC-like protein
IF189_RS25665	COG0134	indole-3-glycerol-phosphate synthase activity
IF189_RS25670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IF189_RS25675	COG0512	Glutamine amidotransferase of anthranilate synthase
IF189_RS25690	COG0546	phosphoglycolate phosphatase activity
IF189_RS25695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IF189_RS25700	COG1454	alcohol dehydrogenase
IF189_RS25710	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS25720	COG3842	ATPase activity
IF189_RS25725	COG2197	response regulator
IF189_RS25740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IF189_RS25745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IF189_RS25750	COG3178	'Phosphotransferase
IF189_RS25755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IF189_RS25760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF189_RS25765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IF189_RS25770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IF189_RS25775	COG2967	ApaG domain
IF189_RS25780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IF189_RS25785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF189_RS25790	COG2766	serine protein kinase
IF189_RS25795	COG2718	Belongs to the UPF0229 family
IF189_RS25800	COG2719	SpoVR family
IF189_RS25805	COG0617	tRNA 3'-terminal CCA addition
IF189_RS25815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IF189_RS25820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IF189_RS25825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IF189_RS25830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IF189_RS25835	COG0358	DNA primase activity
IF189_RS25840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IF189_RS25865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IF189_RS25870	COG1025	Belongs to the peptidase M16 family
IF189_RS25880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IF189_RS25885	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IF189_RS25895	COG0535	radical SAM domain protein
IF189_RS25920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IF189_RS25925	COG0583	DNA-binding transcription factor activity
IF189_RS25930	COG1960	acyl-CoA dehydrogenase activity
IF189_RS25935	COG1960	acyl-CoA dehydrogenase activity
IF189_RS25940	COG3706	GGDEF domain
IF189_RS25945	COG1858	cytochrome C peroxidase
IF189_RS25950	COG1960	acyl-CoA dehydrogenase activity
IF189_RS25970	COG1073	alpha beta
IF189_RS25970	COG2226	methyltransferase
IF189_RS25975	COG0156	8-amino-7-oxononanoate synthase activity
IF189_RS25980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IF189_RS25985	COG1040	competence protein
IF189_RS25990	COG3585	molybdate ion transport
IF189_RS25990	COG2005	Transcriptional regulator
IF189_RS26000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IF189_RS26015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IF189_RS26020	COG0745	RESPONSE REGULATOR receiver
IF189_RS26030	COG1199	ATP-dependent helicase activity
IF189_RS26030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF189_RS26035	COG1595	DNA-templated transcription, initiation
IF189_RS26040	COG3712	iron ion homeostasis
IF189_RS26045	COG4774	siderophore transport
IF189_RS26065	COG4452	Inner membrane protein CreD
IF189_RS26070	COG2205	protein histidine kinase activity
IF189_RS26075	COG0745	RESPONSE REGULATOR receiver
IF189_RS26080	COG4067	protein conserved in archaea
IF189_RS26080	COG0189	ligase activity
IF189_RS26085	COG0204	Acyl-transferase
IF189_RS26095	COG1595	DNA-templated transcription, initiation
IF189_RS26105	COG1063	alcohol dehydrogenase
IF189_RS26135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF189_RS26150	COG1028	Short-chain dehydrogenase reductase Sdr
IF189_RS26165	COG1017	nitric oxide dioxygenase activity
IF189_RS26165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF189_RS26170	COG4638	Rieske (2fe-2S)
IF189_RS26180	COG1858	cytochrome C peroxidase
IF189_RS26195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IF189_RS26200	COG0247	lactate metabolic process
IF189_RS26200	COG2181	nitrate reductase activity
IF189_RS26205	COG1902	pentaerythritol trinitrate reductase activity
IF189_RS26205	COG0446	pyridine nucleotide-disulphide oxidoreductase
IF189_RS26240	COG3246	L-lysine catabolic process to acetate
IF189_RS26245	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF189_RS26270	COG1760	l-serine dehydratase
IF189_RS26280	COG4176	ABC-type proline glycine betaine transport system permease component
IF189_RS26285	COG4175	Glycine betaine
IF189_RS26290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF189_RS26295	COG1309	transcriptional regulator
IF189_RS26300	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS26305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IF189_RS26315	COG0312	modulator of DNA gyrase
IF189_RS26320	COG0477	Major facilitator Superfamily
IF189_RS26325	COG0513	Belongs to the DEAD box helicase family
IF189_RS26330	COG2081	HI0933 family
IF189_RS26335	COG1289	transmembrane transporter activity
IF189_RS26345	COG2153	protein acetylation
IF189_RS26355	COG1451	nucleotide metabolic process
IF189_RS26360	COG3300	MHYT domain
IF189_RS26360	COG5001	Diguanylate cyclase
IF189_RS26410	COG0126	phosphoglycerate kinase activity
IF189_RS26415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF189_RS26425	COG0640	Transcriptional regulator
IF189_RS26430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IF189_RS26435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IF189_RS26470	COG2116	formate transmembrane transporter activity
IF189_RS26480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IF189_RS26485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IF189_RS26495	COG0513	Belongs to the DEAD box helicase family
IF189_RS26500	COG2353	YceI-like domain
IF189_RS26505	COG3038	cytochrome b561
IF189_RS26520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IF189_RS26535	COG1272	protein, Hemolysin III
IF189_RS26575	COG3052	prosthetic group binding
IF189_RS26580	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IF189_RS26595	COG0643	Histidine kinase
IF189_RS26595	COG0784	Response regulator, receiver
IF189_RS26595	COG2198	Histidine kinase
IF189_RS26620	COG0189	ligase activity
IF189_RS26630	COG1678	Uncharacterized ACR, COG1678
IF189_RS26635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IF189_RS26640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IF189_RS26645	COG0540	Belongs to the ATCase OTCase family
IF189_RS26650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IF189_RS26665	COG0791	NLP P60 protein
IF189_RS26690	COG1872	DUF167
IF189_RS26695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IF189_RS26700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IF189_RS26700	COG2813	Specifically methylates the guanine in position
IF189_RS26710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IF189_RS26715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IF189_RS26725	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IF189_RS26730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IF189_RS26735	COG2022	thiamine diphosphate biosynthetic process
IF189_RS26745	COG2363	Small membrane protein
IF189_RS26750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IF189_RS26760	COG2177	Part of the ABC transporter FtsEX involved in
IF189_RS26765	COG2884	Cell division ATP-binding protein ftsE
IF189_RS26770	COG0552	protein localization to endoplasmic reticulum
IF189_RS26775	COG0612	Peptidase, M16
IF189_RS26780	COG0612	Peptidase, M16
IF189_RS26785	COG0742	ribosomal rna small subunit methyltransferase
IF189_RS26790	COG0429	hydrolase of the alpha beta-hydrolase fold
IF189_RS26820	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IF189_RS26825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IF189_RS26830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IF189_RS26840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IF189_RS26850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF189_RS26865	COG2814	Major facilitator Superfamily
IF189_RS26870	COG0129	dihydroxy-acid dehydratase activity
IF189_RS26880	COG1823	symporter activity
IF189_RS26895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IF189_RS26910	COG1840	ABC-type Fe3 transport system, periplasmic component
IF189_RS26915	COG1178	ABC-type Fe3 transport system permease component
IF189_RS26920	COG3842	ATPase activity
IF189_RS26925	COG0583	DNA-binding transcription factor activity
IF189_RS26935	COG0789	Transcriptional regulator
IF189_RS26940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IF189_RS26945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IF189_RS26950	COG0730	response to heat
IF189_RS26965	COG0494	nUDIX hydrolase
IF189_RS26980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IF189_RS26985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IF189_RS26990	COG3204	pilus organization
IF189_RS26995	COG3204	pilus organization
IF189_RS27000	COG0179	Fumarylacetoacetate (FAA) hydrolase
IF189_RS27005	COG0277	FAD linked oxidase domain protein
IF189_RS27010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF189_RS27020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS27025	COG1683	Conserved Protein
IF189_RS27065	COG1177	transmembrane transport
IF189_RS27070	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF189_RS27075	COG3842	ATPase activity
IF189_RS27095	COG0174	glutamine synthetase
IF189_RS27105	COG0174	glutamine synthetase
IF189_RS27120	COG1116	anion transmembrane transporter activity
IF189_RS27125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF189_RS27130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IF189_RS27135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF189_RS27140	COG0431	NADPH-dependent FMN reductase
IF189_RS27145	COG0450	alkyl hydroperoxide reductase
IF189_RS27155	COG4521	taurine ABC transporter
IF189_RS27160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IF189_RS27160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IF189_RS27175	COG1522	sequence-specific DNA binding
IF189_RS27185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF189_RS27195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF189_RS27195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF189_RS27200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IF189_RS27205	COG0509	glycine decarboxylation via glycine cleavage system
IF189_RS27210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IF189_RS27215	COG1178	ABC-type Fe3 transport system permease component
IF189_RS27225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF189_RS27235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF189_RS27240	COG0006	proline dipeptidase activity
IF189_RS27245	COG3079	Belongs to the UPF0149 family
IF189_RS27265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IF189_RS27295	COG2271	Major facilitator Superfamily
IF189_RS27315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IF189_RS27320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IF189_RS27320	COG2755	lipolytic protein G-D-S-L family
IF189_RS27335	COG2186	Transcriptional regulator
IF189_RS27340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS27345	COG0765	amino acid transport
IF189_RS27350	COG0765	amino acid transport
IF189_RS27355	COG1126	abc transporter atp-binding protein
IF189_RS27360	COG0248	Ppx GppA phosphatase
IF189_RS27365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IF189_RS27375	COG0586	Pfam SNARE associated Golgi protein
IF189_RS27385	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IF189_RS27390	COG1671	Belongs to the UPF0178 family
IF189_RS27395	COG0672	)-iron permease
IF189_RS27425	COG1280	lysine exporter protein (LysE YggA)
IF189_RS27435	COG0488	(ABC) transporter
IF189_RS27460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IF189_RS27480	COG0181	hydroxymethylbilane synthase activity
IF189_RS27490	COG0165	Argininosuccinate lyase
IF189_RS27495	COG0625	glutathione transferase activity
IF189_RS27515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF189_RS27525	COG1965	Belongs to the frataxin family
IF189_RS27535	COG0019	diaminopimelate decarboxylase activity
IF189_RS27540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IF189_RS27550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IF189_RS27555	COG1011	Hydrolase
IF189_RS27565	COG0432	Pfam Uncharacterised protein family UPF0047
IF189_RS27570	COG0004	ammonium transporteR
IF189_RS27575	COG0347	Belongs to the P(II) protein family
IF189_RS27595	COG1196	nuclear chromosome segregation
IF189_RS27620	COG5642	Protein of unknown function (DUF2384)
IF189_RS27635	COG0464	growth
IF189_RS27670	COG1959	2 iron, 2 sulfur cluster binding
IF189_RS27685	COG0840	transmembrane signaling receptor activity
IF189_RS27690	COG0583	DNA-binding transcription factor activity
IF189_RS27695	COG0534	Mate efflux family protein
IF189_RS27710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IF189_RS27715	COG0427	acetyl-CoA hydrolase
IF189_RS27730	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IF189_RS27745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IF189_RS27755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS27770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF189_RS27780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF189_RS27785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF189_RS27795	COG1012	belongs to the aldehyde dehydrogenase family
IF189_RS27805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IF189_RS27810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IF189_RS27815	COG0747	negative chemotaxis
IF189_RS27820	COG2003	Belongs to the UPF0758 family
IF189_RS27825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IF189_RS27830	COG0756	dUTP diphosphatase activity
IF189_RS27835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF189_RS27840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IF189_RS27845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IF189_RS27850	COG0708	Exodeoxyribonuclease III
IF189_RS27855	COG0786	glutamate:sodium symporter activity
IF189_RS27865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IF189_RS27870	COG1561	YicC-like family, N-terminal region
IF189_RS27875	COG0194	GDP metabolic process
IF189_RS27880	COG1758	RNA polymerase activity
IF189_RS27885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF189_RS27910	COG0848	biopolymer transport protein
IF189_RS27920	COG0583	DNA-binding transcription factor activity
IF189_RS27925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IF189_RS28005	COG1090	epimerase
IF189_RS28010	COG3755	Protein conserved in bacteria
IF189_RS28090	COG2204	response regulator
IF189_RS28200	COG3161	chorismate lyase activity
IF189_RS28205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IF189_RS28225	COG1253	flavin adenine dinucleotide binding
IF189_RS28230	COG0739	heme binding
IF189_RS28240	COG0704	Plays a role in the regulation of phosphate uptake
IF189_RS28245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IF189_RS28250	COG0573	inorganic phosphate transmembrane transporter activity
IF189_RS28265	COG0477	Major facilitator Superfamily
IF189_RS28270	COG1607	acyl-coa hydrolase
IF189_RS28300	COG0583	DNA-binding transcription factor activity
IF189_RS28305	COG1027	Aspartate ammonia-lyase
IF189_RS28310	COG1115	amino acid carrier protein
IF189_RS28315	COG0252	asparaginase activity
IF189_RS28380	COG5016	pyruvate
IF189_RS28380	COG0511	ligase activity, forming carbon-carbon bonds
IF189_RS28385	COG0439	Biotin carboxylase
IF189_RS28390	COG0583	DNA-binding transcription factor activity
IF189_RS28410	COG0210	DNA helicase
IF189_RS28430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IF189_RS28430	COG4651	solute:proton antiporter activity
IF189_RS28435	COG1607	acyl-coa hydrolase
IF189_RS28440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IF189_RS28450	COG0523	cobalamin synthesis protein
IF189_RS28475	COG0860	N-Acetylmuramoyl-L-alanine amidase
IF189_RS28480	COG1469	GTP cyclohydrolase I activity
IF189_RS28485	COG1121	(ABC) transporter
IF189_RS28495	COG0803	Belongs to the bacterial solute-binding protein 9 family
IF189_RS28505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IF189_RS28515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF189_RS28520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IF189_RS28525	COG2217	Heavy metal translocating P-type atpase
IF189_RS28545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF189_RS28575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF189_RS28620	COG0438	transferase activity, transferring glycosyl groups
IF189_RS28630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF189_RS28630	COG1017	nitric oxide dioxygenase activity
IF189_RS28635	COG0625	glutathione transferase activity
IF189_RS28640	COG0583	DNA-binding transcription factor activity
IF189_RS28645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF189_RS28650	COG4215	(ABC) transporter
IF189_RS28670	COG1737	Transcriptional regulator
IF189_RS28675	COG1113	amino acid transport
IF189_RS28680	COG2986	histidine ammonia-lyase
IF189_RS28685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IF189_RS28690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IF189_RS28695	COG1349	DNA-binding transcription factor activity
IF189_RS28700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IF189_RS28705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IF189_RS28710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IF189_RS28715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IF189_RS28720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IF189_RS28725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IF189_RS28730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IF189_RS28740	COG0356	it plays a direct role in the translocation of protons across the membrane
IF189_RS28745	COG3312	ion transport
IF189_RS28750	COG1475	DNA binding
IF189_RS28755	COG1192	Involved in chromosome partitioning
IF189_RS28760	COG0357	Ribosomal RNA small subunit methyltransferase G
IF189_RS28765	COG0445	tRNA wobble uridine modification
IF189_RS28770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IF189_RS28775	COG0706	membrane insertase activity
IF189_RS28780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IF189_RS28785	COG0594	ribonuclease P activity
IF189_RS28790	COG0230	Belongs to the bacterial ribosomal protein bL34 family