locus-tag	class	description
FXO12_RS00025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FXO12_RS00030	COG0066	3-isopropylmalate dehydratase activity
FXO12_RS00035	COG2226	methyltransferase
FXO12_RS00040	COG0473	3-isopropylmalate dehydrogenase activity
FXO12_RS00065	COG0135	phosphoribosylanthranilate isomerase activity
FXO12_RS00070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FXO12_RS00075	COG0285	dihydrofolate synthase activity
FXO12_RS00080	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXO12_RS00085	COG1286	toxin biosynthetic process
FXO12_RS00120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXO12_RS00130	COG2010	Cytochrome c
FXO12_RS00135	COG3608	succinylglutamate desuccinylase aspartoacylase
FXO12_RS00135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FXO12_RS00140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS00270	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
FXO12_RS00315	COG4626	Terminase
FXO12_RS00315	COG1802	Transcriptional regulator
FXO12_RS00460	COG0642	Histidine kinase
FXO12_RS00475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXO12_RS00490	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXO12_RS00515	COG1879	ABC-type sugar transport system periplasmic component
FXO12_RS00520	COG1129	ABC transporter
FXO12_RS00525	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS00530	COG1609	Transcriptional regulator
FXO12_RS00535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXO12_RS00540	COG1869	D-ribose catabolic process
FXO12_RS00565	COG1278	Cold shock
FXO12_RS00575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FXO12_RS00580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FXO12_RS00585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXO12_RS00590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXO12_RS00595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXO12_RS00600	COG0072	phenylalanine-tRNA ligase activity
FXO12_RS00605	COG0776	regulation of translation
FXO12_RS00630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXO12_RS00650	COG0270	DNA (cytosine-5-)-methyltransferase activity
FXO12_RS00755	COG1484	DNA-dependent DNA replication
FXO12_RS00915	COG1196	nuclear chromosome segregation
FXO12_RS00965	COG2135	peptidase activity
FXO12_RS01000	COG1609	Transcriptional regulator
FXO12_RS01005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FXO12_RS01010	COG1459	type II secretion system
FXO12_RS01015	COG2165	general secretion pathway protein
FXO12_RS01025	COG2165	general secretion pathway protein
FXO12_RS01035	COG3156	type II secretion system protein K
FXO12_RS01040	COG3166	PFAM Fimbrial assembly family protein
FXO12_RS01055	COG1450	Type ii and iii secretion system protein
FXO12_RS01070	COG1126	abc transporter atp-binding protein
FXO12_RS01080	COG1231	oxidoreductase activity
FXO12_RS01100	COG3121	Chaperone
FXO12_RS01110	COG2197	response regulator
FXO12_RS01115	COG0784	Response regulator, receiver
FXO12_RS01115	COG2205	protein histidine kinase activity
FXO12_RS01120	COG2203	Gaf domain
FXO12_RS01120	COG2199	diguanylate cyclase activity
FXO12_RS01120	COG2200	EAL domain
FXO12_RS01125	COG2205	protein histidine kinase activity
FXO12_RS01125	COG0784	Response regulator, receiver
FXO12_RS01135	COG3121	Chaperone
FXO12_RS01150	COG0667	Aldo Keto reductase
FXO12_RS01155	COG0625	glutathione transferase activity
FXO12_RS01165	COG0583	DNA-binding transcription factor activity
FXO12_RS01180	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS01185	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS01190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXO12_RS01200	COG0531	amino acid
FXO12_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS01235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS01240	COG1846	Transcriptional regulator
FXO12_RS01250	COG3971	2-oxopent-4-enoate hydratase activity
FXO12_RS01255	COG2271	Major facilitator Superfamily
FXO12_RS01265	COG3384	dioxygenase
FXO12_RS01270	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS01290	COG1538	Outer membrane efflux protein
FXO12_RS01310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FXO12_RS01315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FXO12_RS01350	COG1879	ABC-type sugar transport system periplasmic component
FXO12_RS01360	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS01365	COG1063	alcohol dehydrogenase
FXO12_RS01370	COG1070	Carbohydrate kinase
FXO12_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS01380	COG1609	Transcriptional regulator
FXO12_RS01425	COG2186	Transcriptional regulator
FXO12_RS01435	COG1538	Outer membrane efflux protein
FXO12_RS01440	COG0577	efflux transmembrane transporter activity
FXO12_RS01440	COG1136	(ABC) transporter
FXO12_RS01445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS01480	COG4160	amino acid transport
FXO12_RS01485	COG4215	(ABC) transporter
FXO12_RS01495	COG2423	ornithine cyclodeaminase activity
FXO12_RS01510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXO12_RS01515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXO12_RS01525	COG0022	dehydrogenase e1 component
FXO12_RS01530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FXO12_RS01535	COG1522	sequence-specific DNA binding
FXO12_RS01545	COG0640	Transcriptional regulator
FXO12_RS01555	COG0730	response to heat
FXO12_RS01590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FXO12_RS01600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXO12_RS01615	COG2372	response to copper ion
FXO12_RS01620	COG1309	transcriptional regulator
FXO12_RS01640	COG1953	Uracil, thiamine, allantoin
FXO12_RS01655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS01675	COG1686	Belongs to the peptidase S11 family
FXO12_RS01680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FXO12_RS01705	COG0544	peptidyl-prolyl cis-trans isomerase activity
FXO12_RS01710	COG0740	serine-type endopeptidase activity
FXO12_RS01715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FXO12_RS01720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXO12_RS01725	COG0776	regulation of translation
FXO12_RS01730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXO12_RS01735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXO12_RS01745	COG0583	DNA-binding transcription factor activity
FXO12_RS01760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXO12_RS01765	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXO12_RS01765	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS01775	COG3038	cytochrome b561
FXO12_RS01780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXO12_RS01785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FXO12_RS01790	COG0583	DNA-binding transcription factor activity
FXO12_RS01800	COG2271	Major facilitator Superfamily
FXO12_RS01805	COG0217	transcriptional regulatory protein
FXO12_RS01815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FXO12_RS01875	COG2866	Carboxypeptidase
FXO12_RS01900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FXO12_RS01905	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS01910	COG0318	PFAM AMP-dependent synthetase and ligase
FXO12_RS01920	COG0789	Transcriptional regulator
FXO12_RS01930	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS01940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FXO12_RS01945	COG0708	Exodeoxyribonuclease III
FXO12_RS01955	COG0729	surface antigen
FXO12_RS01960	COG2911	Protein conserved in bacteria
FXO12_RS01965	COG1846	Transcriptional regulator
FXO12_RS01975	COG1566	PFAM secretion protein HlyD family protein
FXO12_RS01980	COG2814	Major facilitator Superfamily
FXO12_RS01985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXO12_RS01995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXO12_RS02000	COG0215	cysteine-tRNA ligase activity
FXO12_RS02005	COG1320	monovalent cation:proton antiporter activity
FXO12_RS02010	COG2212	antiporter activity
FXO12_RS02020	COG0651	ATP synthesis coupled electron transport
FXO12_RS02025	COG1006	Multisubunit Na H antiporter MnhC subunit
FXO12_RS02030	COG2111	Na H antiporter
FXO12_RS02030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FXO12_RS02050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS02060	COG1136	(ABC) transporter
FXO12_RS02060	COG0577	efflux transmembrane transporter activity
FXO12_RS02065	COG0577	efflux transmembrane transporter activity
FXO12_RS02065	COG1136	(ABC) transporter
FXO12_RS02085	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS02125	COG1007	ATP synthesis coupled electron transport
FXO12_RS02140	COG0713	ATP synthesis coupled electron transport
FXO12_RS02150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXO12_RS02155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FXO12_RS02160	COG1034	ATP synthesis coupled electron transport
FXO12_RS02175	COG0649	NAD binding
FXO12_RS02175	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXO12_RS02180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXO12_RS02185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXO12_RS02190	COG2224	Isocitrate lyase
FXO12_RS02200	COG2153	protein acetylation
FXO12_RS02205	COG2850	peptidyl-arginine hydroxylation
FXO12_RS02215	COG2915	High frequency lysogenization protein hflD homolog
FXO12_RS02220	COG0482	sulfurtransferase activity
FXO12_RS02245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FXO12_RS02250	COG0542	response to heat
FXO12_RS02255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FXO12_RS02260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FXO12_RS02265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FXO12_RS02270	COG1674	ftsk spoiiie
FXO12_RS02275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FXO12_RS02280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXO12_RS02285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FXO12_RS02290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FXO12_RS02295	COG1648	precorrin-2 dehydrogenase activity
FXO12_RS02295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FXO12_RS02300	COG0435	Glutathione S-transferase
FXO12_RS02305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FXO12_RS02310	COG2920	part of a sulfur-relay system
FXO12_RS02330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXO12_RS02335	COG3091	SprT-like family
FXO12_RS02345	COG0037	tRNA processing
FXO12_RS02365	COG1393	Belongs to the ArsC family
FXO12_RS02385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXO12_RS02390	COG2205	protein histidine kinase activity
FXO12_RS02390	COG5002	protein histidine kinase activity
FXO12_RS02390	COG0784	Response regulator, receiver
FXO12_RS02410	COG2333	competence protein COMEC
FXO12_RS02410	COG0658	competence protein
FXO12_RS02415	COG0811	peptide transport
FXO12_RS02420	COG0848	biopolymer transport protein
FXO12_RS02425	COG1663	tetraacyldisaccharide 4'-kinase activity
FXO12_RS02430	COG2835	tetraacyldisaccharide 4'-kinase activity
FXO12_RS02435	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FXO12_RS02440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXO12_RS02445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXO12_RS02485	COG3284	Transcriptional regulator
FXO12_RS02490	COG3842	ATPase activity
FXO12_RS02495	COG3842	ATPase activity
FXO12_RS02505	COG0395	ABC-type sugar transport system, permease component
FXO12_RS02530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FXO12_RS02535	COG1063	alcohol dehydrogenase
FXO12_RS02560	COG2814	Major facilitator Superfamily
FXO12_RS02600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS02605	COG1136	(ABC) transporter
FXO12_RS02605	COG0577	efflux transmembrane transporter activity
FXO12_RS02635	COG1522	sequence-specific DNA binding
FXO12_RS02645	COG1741	Belongs to the pirin family
FXO12_RS02665	COG4977	sequence-specific DNA binding
FXO12_RS02665	COG1917	Cupin 2, conserved barrel domain protein
FXO12_RS02680	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FXO12_RS02685	COG1335	isochorismatase
FXO12_RS02690	COG0583	DNA-binding transcription factor activity
FXO12_RS02700	COG3447	MASE1 domain protein
FXO12_RS02700	COG5001	Diguanylate cyclase
FXO12_RS02700	COG5002	protein histidine kinase activity
FXO12_RS02710	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
FXO12_RS02730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXO12_RS02735	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS02740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXO12_RS02760	COG0583	DNA-binding transcription factor activity
FXO12_RS02765	COG1349	DNA-binding transcription factor activity
FXO12_RS02770	COG1304	FMN binding
FXO12_RS02780	COG0494	nUDIX hydrolase
FXO12_RS02785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FXO12_RS02800	COG0587	DNA-directed DNA polymerase activity
FXO12_RS02805	COG0784	Response regulator, receiver
FXO12_RS02805	COG4191	Histidine kinase
FXO12_RS02830	COG2072	flavoprotein involved in K transport
FXO12_RS02835	COG2197	response regulator
FXO12_RS02895	COG2204	response regulator
FXO12_RS02950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FXO12_RS02970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FXO12_RS02975	COG2890	protein-(glutamine-N5) methyltransferase activity
FXO12_RS03005	COG0673	inositol 2-dehydrogenase activity
FXO12_RS03015	COG1280	lysine exporter protein (LysE YggA)
FXO12_RS03020	COG2207	Transcriptional regulator
FXO12_RS03025	COG4172	Belongs to the ABC transporter superfamily
FXO12_RS03030	COG4239	(ABC) transporter, permease
FXO12_RS03035	COG4174	ABC transporter (Permease)
FXO12_RS03040	COG4166	transmembrane transport
FXO12_RS03045	COG4166	transmembrane transport
FXO12_RS03050	COG0741	lytic transglycosylase activity
FXO12_RS03050	COG1388	LysM domain
FXO12_RS03055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXO12_RS03065	COG0328	RNA-DNA hybrid ribonuclease activity
FXO12_RS03075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXO12_RS03080	COG1982	Orn Lys Arg decarboxylase major
FXO12_RS03105	COG0431	NADPH-dependent FMN reductase
FXO12_RS03110	COG0028	Belongs to the TPP enzyme family
FXO12_RS03150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FXO12_RS03160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FXO12_RS03160	COG0316	Belongs to the HesB IscA family
FXO12_RS03210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FXO12_RS03215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXO12_RS03225	COG3139	Protein of unknown function (DUF1315)
FXO12_RS03235	COG0308	aminopeptidase N
FXO12_RS03255	COG2267	carboxylic ester hydrolase activity
FXO12_RS03260	COG3239	Fatty acid desaturase
FXO12_RS03280	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS03295	COG0183	Belongs to the thiolase family
FXO12_RS03300	COG0318	PFAM AMP-dependent synthetase and ligase
FXO12_RS03305	COG0673	inositol 2-dehydrogenase activity
FXO12_RS03325	COG2706	6-phosphogluconolactonase activity
FXO12_RS03360	COG0420	3'-5' exonuclease activity
FXO12_RS03390	COG0714	Associated with various cellular activities
FXO12_RS03405	COG2186	Transcriptional regulator
FXO12_RS03420	COG2818	Glycosylase
FXO12_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS03455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXO12_RS03470	COG0814	amino acid
FXO12_RS03485	COG0589	response to stress
FXO12_RS03500	COG0745	RESPONSE REGULATOR receiver
FXO12_RS03505	COG2205	protein histidine kinase activity
FXO12_RS03520	COG0583	DNA-binding transcription factor activity
FXO12_RS03525	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
FXO12_RS03530	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS03535	COG2079	MmgE PrpD family protein
FXO12_RS03585	COG0697	spore germination
FXO12_RS03590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXO12_RS03605	COG0154	amidase activity
FXO12_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS03630	COG1609	Transcriptional regulator
FXO12_RS03635	COG0673	inositol 2-dehydrogenase activity
FXO12_RS03640	COG2223	nitrite transmembrane transporter activity
FXO12_RS03645	COG2207	Transcriptional regulator
FXO12_RS03800	COG4373	Mu-like prophage FluMu protein gp28
FXO12_RS03810	COG2369	cell adhesion
FXO12_RS03940	COG2207	Transcriptional regulator
FXO12_RS03960	COG2271	Major facilitator Superfamily
FXO12_RS03965	COG0596	Alpha beta hydrolase
FXO12_RS03975	COG0583	DNA-binding transcription factor activity
FXO12_RS04010	COG1335	isochorismatase
FXO12_RS04015	COG1944	ATP diphosphatase activity
FXO12_RS04020	COG0626	cystathionine gamma-synthase activity
FXO12_RS04035	COG2814	Major facilitator Superfamily
FXO12_RS04085	COG0583	DNA-binding transcription factor activity
FXO12_RS04090	COG0840	transmembrane signaling receptor activity
FXO12_RS04140	COG1640	4-alpha-glucanotransferase
FXO12_RS04145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FXO12_RS04150	COG0297	glycogen (starch) synthase activity
FXO12_RS04155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXO12_RS04160	COG0596	Alpha beta hydrolase
FXO12_RS04165	COG1238	metal cluster binding
FXO12_RS04180	COG0667	Aldo Keto reductase
FXO12_RS04185	COG0583	DNA-binding transcription factor activity
FXO12_RS04205	COG1116	anion transmembrane transporter activity
FXO12_RS04205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXO12_RS04210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXO12_RS04215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXO12_RS04230	COG2366	antibiotic biosynthetic process
FXO12_RS04265	COG1397	ADP-ribosylglycohydrolase
FXO12_RS04280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXO12_RS04285	COG3938	Belongs to the proline racemase family
FXO12_RS04290	COG0531	amino acid
FXO12_RS04315	COG0583	DNA-binding transcription factor activity
FXO12_RS04320	COG1335	isochorismatase
FXO12_RS04325	COG1335	isochorismatase
FXO12_RS04330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FXO12_RS04340	COG0581	inorganic phosphate transmembrane transporter activity
FXO12_RS04345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FXO12_RS04365	COG0789	Transcriptional regulator
FXO12_RS04370	COG0778	Nitroreductase
FXO12_RS04420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXO12_RS04430	COG0640	Transcriptional regulator
FXO12_RS04440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FXO12_RS04460	COG0488	(ABC) transporter
FXO12_RS04470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FXO12_RS04490	COG2169	Transcriptional regulator
FXO12_RS04490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXO12_RS04495	COG3145	DNA-N1-methyladenine dioxygenase activity
FXO12_RS04545	COG0450	alkyl hydroperoxide reductase
FXO12_RS04570	COG2200	EAL domain
FXO12_RS04580	COG3121	Chaperone
FXO12_RS04585	COG3188	usher protein
FXO12_RS04590	COG3121	Chaperone
FXO12_RS04600	COG0583	DNA-binding transcription factor activity
FXO12_RS04605	COG0697	spore germination
FXO12_RS04615	COG3539	Fimbrial protein
FXO12_RS04620	COG3121	Chaperone
FXO12_RS04625	COG3188	usher protein
FXO12_RS04635	COG3121	Chaperone
FXO12_RS04645	COG0667	Aldo Keto reductase
FXO12_RS04650	COG0583	DNA-binding transcription factor activity
FXO12_RS04660	COG2271	Major facilitator Superfamily
FXO12_RS04665	COG3835	regulator
FXO12_RS04670	COG1929	Belongs to the glycerate kinase type-1 family
FXO12_RS04695	COG1247	-acetyltransferase
FXO12_RS04700	COG1794	racemase activity, acting on amino acids and derivatives
FXO12_RS04705	COG2124	cytochrome p450
FXO12_RS04710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FXO12_RS04715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FXO12_RS04720	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXO12_RS04740	COG2198	Histidine kinase
FXO12_RS04740	COG0784	Response regulator, receiver
FXO12_RS04740	COG2205	protein histidine kinase activity
FXO12_RS04745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FXO12_RS04755	COG2205	protein histidine kinase activity
FXO12_RS04755	COG0784	Response regulator, receiver
FXO12_RS04755	COG5002	protein histidine kinase activity
FXO12_RS04780	COG3781	membrane
FXO12_RS04785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXO12_RS04800	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS04805	COG1024	Enoyl-CoA hydratase
FXO12_RS04810	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS04815	COG1024	Enoyl-CoA hydratase
FXO12_RS04840	COG2076	Multidrug Resistance protein
FXO12_RS04845	COG2076	Multidrug Resistance protein
FXO12_RS04850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FXO12_RS04855	COG0726	polysaccharide deacetylase
FXO12_RS04860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FXO12_RS04860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXO12_RS04865	COG0463	Glycosyl transferase, family 2
FXO12_RS04875	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXO12_RS04880	COG2814	Major facilitator Superfamily
FXO12_RS04945	COG1074	ATP-dependent DNA helicase activity
FXO12_RS04950	COG1074	ATP-dependent DNA helicase activity
FXO12_RS04975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FXO12_RS04985	COG0596	Alpha beta hydrolase
FXO12_RS04990	COG3237	CsbD-like
FXO12_RS05005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXO12_RS05010	COG1024	Enoyl-CoA hydratase
FXO12_RS05010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FXO12_RS05025	COG0583	DNA-binding transcription factor activity
FXO12_RS05035	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS05040	COG0531	amino acid
FXO12_RS05055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXO12_RS05065	COG2205	protein histidine kinase activity
FXO12_RS05070	COG0745	RESPONSE REGULATOR receiver
FXO12_RS05085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FXO12_RS05090	COG1733	regulation of RNA biosynthetic process
FXO12_RS05095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXO12_RS05105	COG0826	peptidase U32
FXO12_RS05110	COG0697	spore germination
FXO12_RS05115	COG1522	sequence-specific DNA binding
FXO12_RS05145	COG2308	Evidence 4 Homologs of previously reported genes of
FXO12_RS05165	COG1199	ATP-dependent helicase activity
FXO12_RS05180	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXO12_RS05225	COG1113	amino acid transport
FXO12_RS05230	COG2197	response regulator
FXO12_RS05245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS05260	COG0210	DNA helicase
FXO12_RS05275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXO12_RS05285	COG0604	alcohol dehydrogenase
FXO12_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS05285	COG3321	synthase
FXO12_RS05340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXO12_RS05345	COG1309	transcriptional regulator
FXO12_RS05350	COG4325	translation initiation factor activity
FXO12_RS05355	COG0583	DNA-binding transcription factor activity
FXO12_RS05390	COG2207	Transcriptional regulator
FXO12_RS05420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXO12_RS05440	COG2133	pyrroloquinoline quinone binding
FXO12_RS05450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FXO12_RS05485	COG0488	(ABC) transporter
FXO12_RS05490	COG2814	Major facilitator Superfamily
FXO12_RS05500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXO12_RS05505	COG0583	DNA-binding transcription factor activity
FXO12_RS05520	COG1968	undecaprenyl-diphosphatase activity
FXO12_RS05525	COG0840	transmembrane signaling receptor activity
FXO12_RS05545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FXO12_RS05555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXO12_RS05580	COG2816	NAD+ diphosphatase activity
FXO12_RS05585	COG1024	Enoyl-CoA hydratase
FXO12_RS05590	COG3012	SEC-C Motif Domain Protein
FXO12_RS05590	COG3318	Belongs to the UPF0149 family
FXO12_RS05595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXO12_RS05625	COG2814	Major facilitator Superfamily
FXO12_RS05630	COG2186	Transcriptional regulator
FXO12_RS05635	COG0579	oxidoreductase
FXO12_RS05640	COG0477	Major facilitator Superfamily
FXO12_RS05650	COG0784	Response regulator, receiver
FXO12_RS05650	COG4191	Histidine kinase
FXO12_RS05660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FXO12_RS05680	COG1285	pathogenesis
FXO12_RS05690	COG0348	domain, Protein
FXO12_RS05695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXO12_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS05710	COG1538	Outer membrane efflux protein
FXO12_RS05760	COG1175	transmembrane transport
FXO12_RS05780	COG1070	Carbohydrate kinase
FXO12_RS05805	COG0024	Methionine aminopeptidase
FXO12_RS05810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXO12_RS05815	COG0730	response to heat
FXO12_RS05835	COG2205	protein histidine kinase activity
FXO12_RS05840	COG0745	RESPONSE REGULATOR receiver
FXO12_RS05845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS05850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXO12_RS05880	COG1609	Transcriptional regulator
FXO12_RS05890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXO12_RS05910	COG2233	PERMEase
FXO12_RS05920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXO12_RS05925	COG0583	DNA-binding transcription factor activity
FXO12_RS05990	COG2204	response regulator
FXO12_RS06000	COG0561	phosphatase activity
FXO12_RS06005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXO12_RS06010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FXO12_RS06015	COG2194	sulfuric ester hydrolase activity
FXO12_RS06035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FXO12_RS06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS06100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXO12_RS06105	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS06110	COG1129	ABC transporter
FXO12_RS06120	COG0673	inositol 2-dehydrogenase activity
FXO12_RS06125	COG0673	inositol 2-dehydrogenase activity
FXO12_RS06130	COG3962	Belongs to the TPP enzyme family
FXO12_RS06140	COG3718	enzyme involved in inositol metabolism
FXO12_RS06150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXO12_RS06165	COG0745	RESPONSE REGULATOR receiver
FXO12_RS06170	COG2205	protein histidine kinase activity
FXO12_RS06205	COG0625	glutathione transferase activity
FXO12_RS06225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FXO12_RS06230	COG0019	diaminopimelate decarboxylase activity
FXO12_RS06240	COG2066	Belongs to the glutaminase family
FXO12_RS06255	COG2207	Transcriptional regulator
FXO12_RS06275	COG0693	protein deglycase activity
FXO12_RS06320	COG1999	signal sequence binding
FXO12_RS06335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXO12_RS06340	COG4166	transmembrane transport
FXO12_RS06345	COG4174	ABC transporter (Permease)
FXO12_RS06350	COG4239	(ABC) transporter, permease
FXO12_RS06355	COG4172	Belongs to the ABC transporter superfamily
FXO12_RS06365	COG2610	gluconate transmembrane transporter activity
FXO12_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS06375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXO12_RS06385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXO12_RS06390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXO12_RS06410	COG1126	abc transporter atp-binding protein
FXO12_RS06415	COG0765	amino acid transport
FXO12_RS06420	COG0765	amino acid transport
FXO12_RS06440	COG1253	flavin adenine dinucleotide binding
FXO12_RS06455	COG0698	ribose 5-phosphate isomerase
FXO12_RS06460	COG1129	ABC transporter
FXO12_RS06465	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS06470	COG1879	ABC-type sugar transport system periplasmic component
FXO12_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS06480	COG1063	alcohol dehydrogenase
FXO12_RS06485	COG2376	Dihydroxyacetone kinase
FXO12_RS06495	COG0616	signal peptide processing
FXO12_RS06515	COG5383	Protein conserved in bacteria
FXO12_RS06535	COG0583	DNA-binding transcription factor activity
FXO12_RS06540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FXO12_RS06545	COG0326	Molecular chaperone. Has ATPase activity
FXO12_RS06565	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FXO12_RS06570	COG0596	Alpha beta hydrolase
FXO12_RS06580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXO12_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS06605	COG0583	DNA-binding transcription factor activity
FXO12_RS06610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS06620	COG0174	glutamine synthetase
FXO12_RS06635	COG0022	dehydrogenase e1 component
FXO12_RS06640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FXO12_RS06645	COG3284	Transcriptional regulator
FXO12_RS06660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXO12_RS06675	COG2814	Major facilitator Superfamily
FXO12_RS06680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS06685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXO12_RS06705	COG3706	GGDEF domain
FXO12_RS06710	COG1280	lysine exporter protein (LysE YggA)
FXO12_RS06725	COG2188	Transcriptional regulator
FXO12_RS06800	COG1309	transcriptional regulator
FXO12_RS06805	COG0534	Mate efflux family protein
FXO12_RS06850	COG3248	Nucleoside-binding outer membrane protein
FXO12_RS06905	COG1396	sequence-specific DNA binding
FXO12_RS06920	COG0475	glutathione-regulated potassium exporter activity
FXO12_RS06920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FXO12_RS06955	COG0318	PFAM AMP-dependent synthetase and ligase
FXO12_RS06990	COG0604	alcohol dehydrogenase
FXO12_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS06990	COG3321	synthase
FXO12_RS06995	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS07005	COG1309	transcriptional regulator
FXO12_RS07020	COG1968	undecaprenyl-diphosphatase activity
FXO12_RS07060	COG0673	inositol 2-dehydrogenase activity
FXO12_RS07075	COG0625	glutathione transferase activity
FXO12_RS07100	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS07105	COG1129	ABC transporter
FXO12_RS07110	COG1879	ABC-type sugar transport system periplasmic component
FXO12_RS07120	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS07155	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS07160	COG0640	Transcriptional regulator
FXO12_RS07165	COG2199	diguanylate cyclase activity
FXO12_RS07175	COG3781	membrane
FXO12_RS07195	COG1609	Transcriptional regulator
FXO12_RS07195	COG2207	Transcriptional regulator
FXO12_RS07210	COG2115	Belongs to the xylose isomerase family
FXO12_RS07215	COG4213	ABC transporter substrate-binding protein
FXO12_RS07220	COG1129	ABC transporter
FXO12_RS07225	COG4214	carbohydrate transport
FXO12_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS07275	COG2323	membrane
FXO12_RS07295	COG2203	Gaf domain
FXO12_RS07295	COG3706	GGDEF domain
FXO12_RS07295	COG5001	Diguanylate cyclase
FXO12_RS07295	COG4251	negative regulation of phosphorylation
FXO12_RS07335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FXO12_RS07345	COG1845	cytochrome c oxidase, subunit III
FXO12_RS07360	COG4191	Histidine kinase
FXO12_RS07360	COG0784	Response regulator, receiver
FXO12_RS07365	COG3685	Protein conserved in bacteria
FXO12_RS07370	COG3546	catalase activity
FXO12_RS07395	COG3121	Chaperone
FXO12_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS07405	COG2205	protein histidine kinase activity
FXO12_RS07410	COG2205	protein histidine kinase activity
FXO12_RS07410	COG0784	Response regulator, receiver
FXO12_RS07415	COG2197	response regulator
FXO12_RS07425	COG2203	Gaf domain
FXO12_RS07425	COG5001	Diguanylate cyclase
FXO12_RS07425	COG4251	negative regulation of phosphorylation
FXO12_RS07425	COG3706	GGDEF domain
FXO12_RS07450	COG1546	Belongs to the CinA family
FXO12_RS07450	COG1058	Belongs to the CinA family
FXO12_RS07470	COG4221	oxidoreductase activity
FXO12_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS07515	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXO12_RS07555	COG0322	excinuclease ABC activity
FXO12_RS07560	COG2197	response regulator
FXO12_RS07585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXO12_RS07595	COG2205	protein histidine kinase activity
FXO12_RS07595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS07600	COG2197	response regulator
FXO12_RS07610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FXO12_RS07645	COG2814	Major facilitator Superfamily
FXO12_RS07665	COG0174	glutamine synthetase
FXO12_RS07670	COG4335	DNA alkylation repair
FXO12_RS07695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXO12_RS07700	COG0517	IMP dehydrogenase activity
FXO12_RS07715	COG0583	DNA-binding transcription factor activity
FXO12_RS07720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXO12_RS07750	COG3209	COG3209 Rhs family protein
FXO12_RS07760	COG0113	porphobilinogen synthase activity
FXO12_RS07765	COG0384	phenazine biosynthesis protein PhzF
FXO12_RS07770	COG0625	glutathione transferase activity
FXO12_RS07780	COG0701	Predicted permease
FXO12_RS07785	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FXO12_RS07790	COG0709	Synthesizes selenophosphate from selenide and ATP
FXO12_RS07795	COG1253	flavin adenine dinucleotide binding
FXO12_RS07805	COG0583	DNA-binding transcription factor activity
FXO12_RS07815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FXO12_RS07825	COG3132	Protein of unknown function, DUF480
FXO12_RS07830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXO12_RS07865	COG2056	Na+-H+ antiporter family
FXO12_RS07870	COG0840	transmembrane signaling receptor activity
FXO12_RS07880	COG0745	RESPONSE REGULATOR receiver
FXO12_RS07900	COG0720	synthase
FXO12_RS07905	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FXO12_RS07910	COG0402	S-adenosylhomocysteine deaminase activity
FXO12_RS07930	COG3501	Rhs element vgr protein
FXO12_RS07935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXO12_RS07940	COG2223	nitrite transmembrane transporter activity
FXO12_RS07960	COG4772	TonB-dependent receptor
FXO12_RS07970	COG1595	DNA-templated transcription, initiation
FXO12_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS07985	COG3387	PFAM Glycoside hydrolase 15-related
FXO12_RS07995	COG4977	sequence-specific DNA binding
FXO12_RS08010	COG1595	DNA-templated transcription, initiation
FXO12_RS08015	COG3712	iron ion homeostasis
FXO12_RS08030	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXO12_RS08030	COG0662	Cupin 2, conserved barrel domain protein
FXO12_RS08075	COG0728	peptidoglycan biosynthetic process
FXO12_RS08095	COG0417	DNA replication proofreading
FXO12_RS08110	COG0768	penicillin binding
FXO12_RS08140	COG5006	permease, DMT superfamily
FXO12_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS08185	COG3829	transcription factor binding
FXO12_RS08230	COG1121	(ABC) transporter
FXO12_RS08235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXO12_RS08260	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXO12_RS08305	COG0545	Peptidyl-prolyl cis-trans isomerase
FXO12_RS08310	COG2010	Cytochrome c
FXO12_RS08340	COG2974	May be involved in recombination
FXO12_RS08345	COG0385	Bile acid
FXO12_RS08350	COG2076	Multidrug Resistance protein
FXO12_RS08355	COG0477	Major facilitator Superfamily
FXO12_RS08375	COG0842	Transport permease protein
FXO12_RS08380	COG1131	(ABC) transporter
FXO12_RS08385	COG0625	glutathione transferase activity
FXO12_RS08410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FXO12_RS08415	COG3540	Alkaline phosphatase
FXO12_RS08440	COG0811	peptide transport
FXO12_RS08455	COG0633	Ferredoxin
FXO12_RS08455	COG3217	Mosc domain protein beta barrel domain protein
FXO12_RS08465	COG0786	glutamate:sodium symporter activity
FXO12_RS08480	COG2197	response regulator
FXO12_RS08510	COG2267	carboxylic ester hydrolase activity
FXO12_RS08515	COG0840	transmembrane signaling receptor activity
FXO12_RS08530	COG2130	NADP-dependent
FXO12_RS08535	COG0284	orotidine-5'-phosphate decarboxylase activity
FXO12_RS08545	COG2205	protein histidine kinase activity
FXO12_RS08550	COG0628	permease
FXO12_RS08575	COG1022	Amp-dependent synthetase and ligase
FXO12_RS08590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FXO12_RS08595	COG4771	TonB-dependent receptor
FXO12_RS08605	COG5002	protein histidine kinase activity
FXO12_RS08605	COG2205	protein histidine kinase activity
FXO12_RS08605	COG0784	Response regulator, receiver
FXO12_RS08610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXO12_RS08635	COG1741	Belongs to the pirin family
FXO12_RS08645	COG0326	Molecular chaperone. Has ATPase activity
FXO12_RS08685	COG0045	succinate-CoA ligase (ADP-forming) activity
FXO12_RS08690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXO12_RS08705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FXO12_RS08710	COG1053	succinate dehydrogenase
FXO12_RS08715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FXO12_RS08720	COG2009	succinate dehydrogenase
FXO12_RS08730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXO12_RS08735	COG3162	membrane
FXO12_RS08740	COG2113	Glycine betaine
FXO12_RS08760	COG2853	Lipoprotein
FXO12_RS08765	COG2354	Protein conserved in bacteria
FXO12_RS08770	COG1309	transcriptional regulator
FXO12_RS08780	COG3960	tartronate-semialdehyde synthase activity
FXO12_RS08785	COG3622	Belongs to the hyi family
FXO12_RS08790	COG2084	Dehydrogenase
FXO12_RS08800	COG0469	pyruvate kinase activity
FXO12_RS08810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXO12_RS08820	COG2814	Major facilitator Superfamily
FXO12_RS08825	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FXO12_RS08835	COG4235	cytochrome complex assembly
FXO12_RS08840	COG3088	subunit of a heme lyase
FXO12_RS08850	COG1138	Cytochrome C-type biogenesis protein
FXO12_RS08855	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FXO12_RS08875	COG4133	protoheme IX ABC transporter activity
FXO12_RS08885	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FXO12_RS08890	COG0303	'Molybdopterin
FXO12_RS08895	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXO12_RS08900	COG0746	molybdenum cofactor guanylyltransferase activity
FXO12_RS08910	COG0564	pseudouridine synthase activity
FXO12_RS08930	COG0004	ammonium transporteR
FXO12_RS08960	COG2197	response regulator
FXO12_RS08965	COG2205	protein histidine kinase activity
FXO12_RS08965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS08970	COG1956	GAF domain-containing protein
FXO12_RS08985	COG0386	Belongs to the glutathione peroxidase family
FXO12_RS08990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXO12_RS08995	COG0436	Aminotransferase
FXO12_RS09000	COG0501	Belongs to the peptidase M48B family
FXO12_RS09005	COG0500	methyltransferase
FXO12_RS09010	COG3384	dioxygenase
FXO12_RS09030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FXO12_RS09035	COG3214	Protein conserved in bacteria
FXO12_RS09045	COG0583	DNA-binding transcription factor activity
FXO12_RS09055	COG0583	DNA-binding transcription factor activity
FXO12_RS09060	COG1846	Transcriptional regulator
FXO12_RS09065	COG1764	response to oxidative stress
FXO12_RS09070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FXO12_RS09085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXO12_RS09105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FXO12_RS09120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXO12_RS09135	COG1376	ErfK ybiS ycfS ynhG family protein
FXO12_RS09150	COG4181	ATPase activity
FXO12_RS09155	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FXO12_RS09160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXO12_RS09170	COG1131	(ABC) transporter
FXO12_RS09195	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXO12_RS09200	COG0084	hydrolase, TatD family'
FXO12_RS09210	COG3209	COG3209 Rhs family protein
FXO12_RS09250	COG0745	RESPONSE REGULATOR receiver
FXO12_RS09255	COG2205	protein histidine kinase activity
FXO12_RS09260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FXO12_RS09270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FXO12_RS09300	COG1555	photosystem II stabilization
FXO12_RS09325	COG0438	transferase activity, transferring glycosyl groups
FXO12_RS09330	COG0297	glycogen (starch) synthase activity
FXO12_RS09335	COG1442	glycosyl transferase family 8
FXO12_RS09335	COG1216	Glycosyl transferase, family 2
FXO12_RS09360	COG0776	regulation of translation
FXO12_RS09375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FXO12_RS09380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXO12_RS09385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXO12_RS09395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FXO12_RS09405	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FXO12_RS09410	COG0402	S-adenosylhomocysteine deaminase activity
FXO12_RS09415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FXO12_RS09420	COG0546	phosphoglycolate phosphatase activity
FXO12_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS09430	COG0747	negative chemotaxis
FXO12_RS09440	COG0444	Belongs to the ABC transporter superfamily
FXO12_RS09455	COG0596	Alpha beta hydrolase
FXO12_RS09460	COG2197	response regulator
FXO12_RS09465	COG2267	carboxylic ester hydrolase activity
FXO12_RS09470	COG2233	PERMEase
FXO12_RS09480	COG2814	Major facilitator Superfamily
FXO12_RS09485	COG0583	DNA-binding transcription factor activity
FXO12_RS09490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FXO12_RS09495	COG0583	DNA-binding transcription factor activity
FXO12_RS09505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FXO12_RS09515	COG1611	Belongs to the LOG family
FXO12_RS09535	COG0583	DNA-binding transcription factor activity
FXO12_RS09545	COG0579	oxidoreductase
FXO12_RS09550	COG2814	Major facilitator Superfamily
FXO12_RS09590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXO12_RS09600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXO12_RS09610	COG2204	response regulator
FXO12_RS09620	COG2853	Lipoprotein
FXO12_RS09635	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FXO12_RS09635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FXO12_RS09655	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXO12_RS09660	COG1136	(ABC) transporter
FXO12_RS09665	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXO12_RS09675	COG0584	glycerophosphoryl diester phosphodiesterase
FXO12_RS09680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXO12_RS09695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXO12_RS09705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXO12_RS09750	COG0183	Belongs to the thiolase family
FXO12_RS09755	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXO12_RS09755	COG1024	Enoyl-CoA hydratase
FXO12_RS09770	COG0589	response to stress
FXO12_RS09780	COG0741	lytic transglycosylase activity
FXO12_RS09785	COG1132	(ABC) transporter
FXO12_RS09790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXO12_RS09800	COG0425	Belongs to the sulfur carrier protein TusA family
FXO12_RS09805	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FXO12_RS09820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXO12_RS09830	COG0542	response to heat
FXO12_RS09845	COG1984	allophanate hydrolase subunit 2
FXO12_RS09850	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FXO12_RS09855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FXO12_RS09860	COG0583	DNA-binding transcription factor activity
FXO12_RS09870	COG0121	glutamine amidotransferase
FXO12_RS09880	COG1770	oligopeptidase
FXO12_RS09895	COG1403	HNH endonuclease
FXO12_RS09915	COG2983	Belongs to the UPF0260 family
FXO12_RS09925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXO12_RS09930	COG3100	YcgL domain-containing protein
FXO12_RS09945	COG0174	glutamine synthetase
FXO12_RS09955	COG0583	DNA-binding transcription factor activity
FXO12_RS09965	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FXO12_RS09995	COG0583	DNA-binding transcription factor activity
FXO12_RS10005	COG2910	NAD(P)H-binding
FXO12_RS10020	COG2807	transmembrane transport
FXO12_RS10030	COG0583	DNA-binding transcription factor activity
FXO12_RS10045	COG3239	Fatty acid desaturase
FXO12_RS10085	COG0583	DNA-binding transcription factor activity
FXO12_RS10110	COG0477	Major facilitator Superfamily
FXO12_RS10115	COG0583	DNA-binding transcription factor activity
FXO12_RS10130	COG3077	Addiction module antitoxin, RelB DinJ family
FXO12_RS10135	COG2026	Addiction module toxin, RelE StbE family
FXO12_RS10225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXO12_RS10325	COG0515	serine threonine protein kinase
FXO12_RS10325	COG2815	serine threonine protein kinase
FXO12_RS10465	COG2135	peptidase activity
FXO12_RS10480	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FXO12_RS10570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FXO12_RS10575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FXO12_RS10580	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FXO12_RS10585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXO12_RS10595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXO12_RS10600	COG0425	Belongs to the sulfur carrier protein TusA family
FXO12_RS10605	COG4783	chaperone-mediated protein folding
FXO12_RS10610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXO12_RS10640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FXO12_RS10645	COG0354	folic acid binding
FXO12_RS10690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FXO12_RS10725	COG2267	carboxylic ester hydrolase activity
FXO12_RS10745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXO12_RS10780	COG1454	alcohol dehydrogenase
FXO12_RS10790	COG1396	sequence-specific DNA binding
FXO12_RS10795	COG0235	Class ii aldolase
FXO12_RS10800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXO12_RS10805	COG3422	double-strand break repair
FXO12_RS10820	COG1629	transport
FXO12_RS10850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXO12_RS10865	COG0154	amidase activity
FXO12_RS10875	COG1473	amidohydrolase
FXO12_RS10910	COG2814	Major facilitator Superfamily
FXO12_RS10915	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS10920	COG1309	transcriptional regulator
FXO12_RS10925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS10935	COG1538	Outer membrane efflux protein
FXO12_RS10950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXO12_RS10955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXO12_RS10965	COG0477	Major facilitator Superfamily
FXO12_RS10970	COG3485	protocatechuate 3,4-dioxygenase
FXO12_RS10975	COG3485	protocatechuate 3,4-dioxygenase
FXO12_RS10980	COG0183	Belongs to the thiolase family
FXO12_RS10985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FXO12_RS10990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXO12_RS10995	COG2814	Major facilitator Superfamily
FXO12_RS11000	COG1414	Transcriptional regulator
FXO12_RS11010	COG0306	phosphate transporter
FXO12_RS11015	COG0583	DNA-binding transcription factor activity
FXO12_RS11025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FXO12_RS11035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXO12_RS11040	COG2271	Major facilitator Superfamily
FXO12_RS11090	COG3220	belongs to the UPF0276 family
FXO12_RS11105	COG0583	DNA-binding transcription factor activity
FXO12_RS11120	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FXO12_RS11130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXO12_RS11140	COG0259	pyridoxamine-phosphate oxidase activity
FXO12_RS11160	COG1199	ATP-dependent helicase activity
FXO12_RS11180	COG3012	SEC-C Motif Domain Protein
FXO12_RS11190	COG0653	protein targeting
FXO12_RS11195	COG2366	antibiotic biosynthetic process
FXO12_RS11205	COG1793	dna ligase
FXO12_RS11215	COG4215	(ABC) transporter
FXO12_RS11220	COG4160	amino acid transport
FXO12_RS11235	COG1201	RNA secondary structure unwinding
FXO12_RS11250	COG0717	Belongs to the dCTP deaminase family
FXO12_RS11255	COG1278	Cold shock
FXO12_RS11270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FXO12_RS11275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FXO12_RS11280	COG0585	pseudouridine synthase activity
FXO12_RS11285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FXO12_RS11290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FXO12_RS11295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXO12_RS11305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FXO12_RS11315	COG0148	phosphopyruvate hydratase activity
FXO12_RS11320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FXO12_RS11325	COG0504	CTP synthase activity
FXO12_RS11330	COG0037	tRNA processing
FXO12_RS11335	COG0825	malonyl-CoA metabolic process
FXO12_RS11340	COG0587	DNA-directed DNA polymerase activity
FXO12_RS11345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FXO12_RS11350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXO12_RS11355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXO12_RS11360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXO12_RS11365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXO12_RS11375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXO12_RS11385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FXO12_RS11395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FXO12_RS11400	COG0233	cytoplasmic translational termination
FXO12_RS11405	COG0528	UMP kinase activity
FXO12_RS11410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FXO12_RS11415	COG0052	Belongs to the universal ribosomal protein uS2 family
FXO12_RS11420	COG0024	Methionine aminopeptidase
FXO12_RS11425	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FXO12_RS11430	COG0436	Aminotransferase
FXO12_RS11435	COG0025	NhaP-type Na H and K H
FXO12_RS11440	COG1393	Belongs to the ArsC family
FXO12_RS11445	COG2171	N-acyltransferase activity
FXO12_RS11450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FXO12_RS11455	COG2166	iron-sulfur cluster assembly
FXO12_RS11460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FXO12_RS11465	COG1215	transferase activity, transferring glycosyl groups
FXO12_RS11470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FXO12_RS11475	COG2226	methyltransferase
FXO12_RS11490	COG2937	Belongs to the GPAT DAPAT family
FXO12_RS11515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS11545	COG0742	ribosomal rna small subunit methyltransferase
FXO12_RS11560	COG1801	Protein of unknown function DUF72
FXO12_RS11575	COG0563	adenylate kinase activity
FXO12_RS11580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FXO12_RS11595	COG2885	chlorophyll binding
FXO12_RS11610	COG1073	alpha beta
FXO12_RS11625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FXO12_RS11645	COG3706	GGDEF domain
FXO12_RS11645	COG2203	Gaf domain
FXO12_RS11645	COG5001	Diguanylate cyclase
FXO12_RS11645	COG4251	negative regulation of phosphorylation
FXO12_RS11650	COG2201	protein-glutamate methylesterase activity
FXO12_RS11665	COG0457	Tetratricopeptide repeat
FXO12_RS11665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FXO12_RS11685	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FXO12_RS11700	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS11705	COG3158	transport of potassium into the cell
FXO12_RS11710	COG3657	addiction module killer protein
FXO12_RS11720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXO12_RS11725	COG0519	Catalyzes the synthesis of GMP from XMP
FXO12_RS11735	COG4807	Protein conserved in bacteria
FXO12_RS11750	COG0583	DNA-binding transcription factor activity
FXO12_RS11780	COG2137	regulation of response to DNA damage stimulus
FXO12_RS11790	COG1546	Belongs to the CinA family
FXO12_RS11800	COG3179	chitinase
FXO12_RS11900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FXO12_RS11905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FXO12_RS11910	COG0489	protein tyrosine kinase activity
FXO12_RS11915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXO12_RS11915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXO12_RS11920	COG2878	Part of a membrane complex involved in electron transport
FXO12_RS11925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXO12_RS11935	COG2197	response regulator
FXO12_RS11940	COG0137	argininosuccinate synthase activity
FXO12_RS11950	COG0418	dihydroorotase activity
FXO12_RS11955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXO12_RS11960	COG0450	alkyl hydroperoxide reductase
FXO12_RS11965	COG2906	2 iron, 2 sulfur cluster binding
FXO12_RS11975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FXO12_RS11980	COG0243	molybdopterin cofactor binding
FXO12_RS11990	COG3842	ATPase activity
FXO12_RS11995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXO12_RS12005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FXO12_RS12020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS12025	COG0765	amino acid transport
FXO12_RS12030	COG0765	amino acid transport
FXO12_RS12035	COG1126	abc transporter atp-binding protein
FXO12_RS12060	COG4191	Histidine kinase
FXO12_RS12075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FXO12_RS12090	COG2076	Multidrug Resistance protein
FXO12_RS12110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXO12_RS12115	COG0583	DNA-binding transcription factor activity
FXO12_RS12125	COG0494	nUDIX hydrolase
FXO12_RS12135	COG2204	response regulator
FXO12_RS12145	COG1858	cytochrome C peroxidase
FXO12_RS12150	COG3290	protein histidine kinase activity
FXO12_RS12160	COG0254	rRNA binding
FXO12_RS12170	COG0069	glutamate synthase activity
FXO12_RS12190	COG1113	amino acid transport
FXO12_RS12230	COG1695	Transcriptional regulator
FXO12_RS12235	COG2375	cellular response to nickel ion
FXO12_RS12245	COG4628	conserved protein (DUF2132)
FXO12_RS12250	COG4206	TonB-dependent receptor
FXO12_RS12280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXO12_RS12295	COG2226	methyltransferase
FXO12_RS12300	COG0500	methyltransferase
FXO12_RS12305	COG0590	tRNA wobble adenosine to inosine editing
FXO12_RS12315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FXO12_RS12320	COG1381	Involved in DNA repair and RecF pathway recombination
FXO12_RS12325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FXO12_RS12330	COG0571	ribonuclease III activity
FXO12_RS12335	COG0681	Belongs to the peptidase S26 family
FXO12_RS12340	COG0481	GTPase activity
FXO12_RS12345	COG0795	lipopolysaccharide-transporting ATPase activity
FXO12_RS12350	COG0795	lipopolysaccharide-transporting ATPase activity
FXO12_RS12355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FXO12_RS12370	COG0525	valine-tRNA ligase activity
FXO12_RS12375	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FXO12_RS12385	COG3081	Nucleoid-associated protein
FXO12_RS12390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXO12_RS12420	COG1595	DNA-templated transcription, initiation
FXO12_RS12425	COG3712	iron ion homeostasis
FXO12_RS12430	COG4772	TonB-dependent receptor
FXO12_RS12435	COG0583	DNA-binding transcription factor activity
FXO12_RS12440	COG0477	Major facilitator Superfamily
FXO12_RS12450	COG0583	DNA-binding transcription factor activity
FXO12_RS12455	COG1760	l-serine dehydratase
FXO12_RS12460	COG0814	amino acid
FXO12_RS12480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FXO12_RS12500	COG0179	Fumarylacetoacetate (FAA) hydrolase
FXO12_RS12505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FXO12_RS12520	COG4774	siderophore transport
FXO12_RS12525	COG2827	Endonuclease containing a URI domain
FXO12_RS12535	COG2197	response regulator
FXO12_RS12540	COG2205	protein histidine kinase activity
FXO12_RS12540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS12545	COG3539	Fimbrial protein
FXO12_RS12550	COG3539	Fimbrial protein
FXO12_RS12555	COG3539	Fimbrial protein
FXO12_RS12565	COG3121	Chaperone
FXO12_RS12570	COG3188	usher protein
FXO12_RS12585	COG2807	transmembrane transport
FXO12_RS12590	COG2186	Transcriptional regulator
FXO12_RS12605	COG1126	abc transporter atp-binding protein
FXO12_RS12610	COG0765	amino acid transport
FXO12_RS12615	COG4597	amino acid ABC transporter
FXO12_RS12620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS12630	COG0513	Belongs to the DEAD box helicase family
FXO12_RS12640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FXO12_RS12645	COG0315	cyclic pyranopterin monophosphate synthase activity
FXO12_RS12655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FXO12_RS12665	COG3022	response to hydroperoxide
FXO12_RS12675	COG1215	transferase activity, transferring glycosyl groups
FXO12_RS12680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS12685	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FXO12_RS12695	COG3420	alginic acid biosynthetic process
FXO12_RS12710	COG1696	Membrane protein involved in D-alanine export
FXO12_RS12725	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXO12_RS12725	COG0662	Cupin 2, conserved barrel domain protein
FXO12_RS12765	COG0300	oxidoreductase activity
FXO12_RS12775	COG0477	Major facilitator Superfamily
FXO12_RS12785	COG1566	PFAM secretion protein HlyD family protein
FXO12_RS12805	COG0583	DNA-binding transcription factor activity
FXO12_RS12810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXO12_RS12830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS12855	COG5002	protein histidine kinase activity
FXO12_RS12865	COG2203	Gaf domain
FXO12_RS12865	COG4251	negative regulation of phosphorylation
FXO12_RS12865	COG5001	Diguanylate cyclase
FXO12_RS12865	COG3706	GGDEF domain
FXO12_RS12870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FXO12_RS12875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FXO12_RS12890	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXO12_RS12895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXO12_RS12900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXO12_RS12905	COG0772	Belongs to the SEDS family
FXO12_RS12910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXO12_RS12915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXO12_RS12920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXO12_RS12925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FXO12_RS12940	COG0275	rRNA processing
FXO12_RS12945	COG2001	Belongs to the MraZ family
FXO12_RS12965	COG0792	nuclease activity
FXO12_RS12970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXO12_RS12975	COG2823	Periplasmic or secreted lipoprotein
FXO12_RS12985	COG2885	chlorophyll binding
FXO12_RS12990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXO12_RS13000	COG2995	paraquat-inducible protein a
FXO12_RS13005	COG3008	intermembrane lipid transfer
FXO12_RS13015	COG2909	trisaccharide binding
FXO12_RS13030	COG0318	PFAM AMP-dependent synthetase and ligase
FXO12_RS13035	COG1280	lysine exporter protein (LysE YggA)
FXO12_RS13040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXO12_RS13045	COG2813	Specifically methylates the guanine in position
FXO12_RS13050	COG2119	membrane
FXO12_RS13055	COG0501	Belongs to the peptidase M48B family
FXO12_RS13060	COG2135	peptidase activity
FXO12_RS13125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXO12_RS13135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXO12_RS13140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FXO12_RS13145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FXO12_RS13150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FXO12_RS13170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FXO12_RS13175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXO12_RS13180	COG1127	ABC transporter
FXO12_RS13190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FXO12_RS13200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FXO12_RS13205	COG1137	ATPase activity
FXO12_RS13210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FXO12_RS13225	COG1660	Displays ATPase and GTPase activities
FXO12_RS13260	COG0312	modulator of DNA gyrase
FXO12_RS13265	COG3028	Belongs to the UPF0307 family
FXO12_RS13270	COG0312	modulator of DNA gyrase
FXO12_RS13275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXO12_RS13285	COG1530	ribonuclease E activity
FXO12_RS13290	COG0424	maF-like protein
FXO12_RS13300	COG1792	Involved in formation and maintenance of cell shape
FXO12_RS13305	COG1077	Cell shape determining protein MreB Mrl
FXO12_RS13310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FXO12_RS13315	COG0154	amidase activity
FXO12_RS13320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FXO12_RS13330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXO12_RS13340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXO12_RS13350	COG2721	sulfolactate sulfo-lyase activity
FXO12_RS13355	COG2271	Major facilitator Superfamily
FXO12_RS13365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXO12_RS13375	COG2186	Transcriptional regulator
FXO12_RS13380	COG2969	positive regulation of protein catabolic process
FXO12_RS13385	COG0625	glutathione transferase activity
FXO12_RS13390	COG2857	Cytochrome c1
FXO12_RS13395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FXO12_RS13400	COG0723	plastoquinol--plastocyanin reductase activity
FXO12_RS13405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FXO12_RS13410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FXO12_RS13415	COG0667	Aldo Keto reductase
FXO12_RS13420	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS13430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FXO12_RS13435	COG0180	Tryptophanyl-tRNA synthetase
FXO12_RS13455	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FXO12_RS13480	COG0747	negative chemotaxis
FXO12_RS13485	COG0747	negative chemotaxis
FXO12_RS13490	COG0747	negative chemotaxis
FXO12_RS13500	COG0747	negative chemotaxis
FXO12_RS13505	COG0601	transmembrane transport
FXO12_RS13510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXO12_RS13515	COG0444	Belongs to the ABC transporter superfamily
FXO12_RS13520	COG4608	Belongs to the ABC transporter superfamily
FXO12_RS13540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FXO12_RS13565	COG0019	diaminopimelate decarboxylase activity
FXO12_RS13580	COG3128	pkhd-type hydroxylase
FXO12_RS13585	COG4774	siderophore transport
FXO12_RS13590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FXO12_RS13610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXO12_RS13610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXO12_RS13610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FXO12_RS13615	COG1105	Belongs to the carbohydrate kinase PfkB family
FXO12_RS13625	COG1609	Transcriptional regulator
FXO12_RS13630	COG0084	hydrolase, TatD family'
FXO12_RS13690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FXO12_RS13695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FXO12_RS13755	COG0582	viral genome integration into host DNA
FXO12_RS13780	COG0237	dephospho-CoA kinase activity
FXO12_RS13785	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXO12_RS13810	COG1252	NADH dehydrogenase
FXO12_RS13820	COG2894	cell division
FXO12_RS13845	COG0305	Participates in initiation and elongation during chromosome replication
FXO12_RS13860	COG3081	Nucleoid-associated protein
FXO12_RS13915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXO12_RS13925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXO12_RS13935	COG0431	NADPH-dependent FMN reductase
FXO12_RS13945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FXO12_RS13950	COG0640	Transcriptional regulator
FXO12_RS14105	COG1074	ATP-dependent DNA helicase activity
FXO12_RS14170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXO12_RS14175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS14235	COG1815	bacterial-type flagellum-dependent cell motility
FXO12_RS14270	COG1230	cation diffusion facilitator family transporter
FXO12_RS14280	COG2963	transposase activity
FXO12_RS14285	COG3436	PFAM IS66 Orf2 family protein
FXO12_RS14290	COG4372	Transposase
FXO12_RS14380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXO12_RS14405	COG0542	response to heat
FXO12_RS14430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS14460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FXO12_RS14465	COG1047	Peptidyl-prolyl cis-trans
FXO12_RS14470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXO12_RS14475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FXO12_RS14480	COG0196	riboflavin kinase activity
FXO12_RS14490	COG0268	Binds directly to 16S ribosomal RNA
FXO12_RS14505	COG0280	phosphate acetyltransferase
FXO12_RS14505	COG0857	belongs to the CobB CobQ family
FXO12_RS14510	COG0204	Acyl-transferase
FXO12_RS14520	COG0175	sulfate reduction
FXO12_RS14530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXO12_RS14540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FXO12_RS14545	COG1090	epimerase
FXO12_RS14550	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FXO12_RS14565	COG0789	Transcriptional regulator
FXO12_RS14570	COG0415	Belongs to the DNA photolyase family
FXO12_RS14580	COG4221	oxidoreductase activity
FXO12_RS14595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FXO12_RS14615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FXO12_RS14620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXO12_RS14630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXO12_RS14635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FXO12_RS14645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FXO12_RS14650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXO12_RS14660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FXO12_RS14665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXO12_RS14670	COG0193	aminoacyl-tRNA hydrolase activity
FXO12_RS14695	COG4669	(LipO)protein
FXO12_RS14735	COG4792	protein secretion
FXO12_RS14745	COG4794	Type iii secretion
FXO12_RS14805	COG0405	Gamma-glutamyltransferase
FXO12_RS14820	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXO12_RS14830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXO12_RS14885	COG0477	Major facilitator Superfamily
FXO12_RS14890	COG2031	fatty acid transporter
FXO12_RS14920	COG0288	reversible hydration of carbon dioxide
FXO12_RS14930	COG0456	acetyltransferase
FXO12_RS14955	COG3008	intermembrane lipid transfer
FXO12_RS14960	COG2995	paraquat-inducible protein a
FXO12_RS14965	COG2995	paraquat-inducible protein a
FXO12_RS15010	COG2233	PERMEase
FXO12_RS15015	COG1309	transcriptional regulator
FXO12_RS15035	COG0387	Pfam Sodium calcium exchanger
FXO12_RS15040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FXO12_RS15045	COG0477	Major facilitator Superfamily
FXO12_RS15055	COG0583	DNA-binding transcription factor activity
FXO12_RS15060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FXO12_RS15065	COG0604	alcohol dehydrogenase
FXO12_RS15075	COG2814	Major facilitator Superfamily
FXO12_RS15090	COG2217	Heavy metal translocating P-type atpase
FXO12_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS15145	COG4964	Belongs to the GSP D family
FXO12_RS15180	COG2197	response regulator
FXO12_RS15215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FXO12_RS15225	COG4953	penicillin-binding protein 1C
FXO12_RS15235	COG2373	Large extracellular alpha-helical protein
FXO12_RS15240	COG0534	Mate efflux family protein
FXO12_RS15250	COG1166	arginine decarboxylase activity
FXO12_RS15255	COG0023	Translation Initiation Factor
FXO12_RS15270	COG3706	GGDEF domain
FXO12_RS15270	COG0745	RESPONSE REGULATOR receiver
FXO12_RS15280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FXO12_RS15295	COG2264	protein methyltransferase activity
FXO12_RS15305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXO12_RS15315	COG0138	bifunctional purine biosynthesis protein purh
FXO12_RS15320	COG0151	Belongs to the GarS family
FXO12_RS15330	COG2095	MarC family integral membrane protein
FXO12_RS15355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXO12_RS15400	COG0683	leucine binding
FXO12_RS15405	COG0559	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS15415	COG0411	ABC transporter
FXO12_RS15425	COG0410	ABC transporter
FXO12_RS15430	COG0829	nickel cation binding
FXO12_RS15435	COG0831	urea catabolic process
FXO12_RS15450	COG0832	Belongs to the urease beta subunit family
FXO12_RS15455	COG0804	urea catabolic process
FXO12_RS15465	COG0484	heat shock protein binding
FXO12_RS15475	COG0443	Heat shock 70 kDa protein
FXO12_RS15495	COG0697	spore germination
FXO12_RS15505	COG2982	Protein involved in outer membrane biogenesis
FXO12_RS15515	COG1309	transcriptional regulator
FXO12_RS15520	COG0791	NLP P60 protein
FXO12_RS15525	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FXO12_RS15530	COG0830	nickel cation binding
FXO12_RS15535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FXO12_RS15555	COG4221	oxidoreductase activity
FXO12_RS15560	COG0410	ABC transporter
FXO12_RS15575	COG0559	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS15585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS15590	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS15595	COG0583	DNA-binding transcription factor activity
FXO12_RS15600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FXO12_RS15605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FXO12_RS15630	COG2307	Protein conserved in bacteria
FXO12_RS15630	COG2308	Evidence 4 Homologs of previously reported genes of
FXO12_RS15660	COG1032	radical SAM domain protein
FXO12_RS15665	COG0305	Participates in initiation and elongation during chromosome replication
FXO12_RS15670	COG0359	binds to the 23S rRNA
FXO12_RS15680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FXO12_RS15685	COG0360	Binds together with S18 to 16S ribosomal RNA
FXO12_RS15690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXO12_RS15695	COG0557	exoribonuclease II activity
FXO12_RS15710	COG1840	ABC-type Fe3 transport system, periplasmic component
FXO12_RS15715	COG1178	ABC-type Fe3 transport system permease component
FXO12_RS15725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FXO12_RS15730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FXO12_RS15735	COG0330	HflC and HflK could
FXO12_RS15740	COG0330	HflC and HflK could
FXO12_RS15745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FXO12_RS15750	COG1923	regulation of RNA biosynthetic process
FXO12_RS15755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FXO12_RS15760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FXO12_RS15765	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXO12_RS15770	COG0802	atpase or kinase
FXO12_RS15775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FXO12_RS15775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FXO12_RS15785	COG2860	membrane
FXO12_RS15790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FXO12_RS15795	COG1162	GTPase activity
FXO12_RS15820	COG0688	phosphatidylethanolamine metabolic process
FXO12_RS15825	COG3830	Belongs to the UPF0237 family
FXO12_RS15825	COG0560	Phosphoserine phosphatase
FXO12_RS15860	COG3150	esterase
FXO12_RS15865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXO12_RS15875	COG0494	nUDIX hydrolase
FXO12_RS15885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FXO12_RS15890	COG1538	Outer membrane efflux protein
FXO12_RS15895	COG1519	Transferase
FXO12_RS15915	COG0667	Aldo Keto reductase
FXO12_RS15925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXO12_RS15930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXO12_RS15930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXO12_RS15935	COG1132	(ABC) transporter
FXO12_RS15945	COG1215	transferase activity, transferring glycosyl groups
FXO12_RS15950	COG0438	transferase activity, transferring glycosyl groups
FXO12_RS15965	COG2192	nodulation
FXO12_RS15975	COG4772	TonB-dependent receptor
FXO12_RS15980	COG0515	serine threonine protein kinase
FXO12_RS16000	COG0438	transferase activity, transferring glycosyl groups
FXO12_RS16005	COG0859	PFAM glycosyl transferase family 9
FXO12_RS16010	COG0859	PFAM glycosyl transferase family 9
FXO12_RS16015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FXO12_RS16035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXO12_RS16040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXO12_RS16050	COG3501	Rhs element vgr protein
FXO12_RS16055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXO12_RS16060	COG0506	proline dehydrogenase activity
FXO12_RS16060	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FXO12_RS16060	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FXO12_RS16065	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS16085	COG3263	regulation of cellular component size
FXO12_RS16090	COG3264	Mechanosensitive ion channel
FXO12_RS16090	COG1196	nuclear chromosome segregation
FXO12_RS16095	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FXO12_RS16110	COG3118	belongs to the thioredoxin family
FXO12_RS16115	COG1192	Involved in chromosome partitioning
FXO12_RS16130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXO12_RS16135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXO12_RS16145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXO12_RS16160	COG2986	histidine ammonia-lyase
FXO12_RS16185	COG2226	methyltransferase
FXO12_RS16195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXO12_RS16205	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS16210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXO12_RS16220	COG0583	DNA-binding transcription factor activity
FXO12_RS16225	COG2814	Major facilitator Superfamily
FXO12_RS16240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FXO12_RS16245	COG0493	'glutamate synthase
FXO12_RS16250	COG0067	glutamate synthase
FXO12_RS16250	COG0069	glutamate synthase activity
FXO12_RS16250	COG0070	glutamate synthase
FXO12_RS16260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FXO12_RS16265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FXO12_RS16295	COG0281	malic enzyme
FXO12_RS16305	COG0254	rRNA binding
FXO12_RS16310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FXO12_RS16315	COG0018	arginyl-trna synthetase
FXO12_RS16325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FXO12_RS16330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FXO12_RS16375	COG2226	methyltransferase
FXO12_RS16385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FXO12_RS16390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FXO12_RS16395	COG0140	phosphoribosyl-ATP diphosphatase activity
FXO12_RS16400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXO12_RS16405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXO12_RS16420	COG0840	transmembrane signaling receptor activity
FXO12_RS16425	COG0840	transmembrane signaling receptor activity
FXO12_RS16430	COG1126	abc transporter atp-binding protein
FXO12_RS16435	COG0765	amino acid transport
FXO12_RS16445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS16450	COG2943	transferase activity, transferring hexosyl groups
FXO12_RS16455	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FXO12_RS16460	COG1490	D-aminoacyl-tRNA deacylase activity
FXO12_RS16465	COG0596	Alpha beta hydrolase
FXO12_RS16475	COG1228	amidohydrolase
FXO12_RS16480	COG1113	amino acid transport
FXO12_RS16485	COG2986	histidine ammonia-lyase
FXO12_RS16490	COG2986	histidine ammonia-lyase
FXO12_RS16495	COG0517	IMP dehydrogenase activity
FXO12_RS16495	COG4175	Glycine betaine
FXO12_RS16500	COG4176	ABC-type proline glycine betaine transport system permease component
FXO12_RS16510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FXO12_RS16515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FXO12_RS16525	COG2188	Transcriptional regulator
FXO12_RS16530	COG0402	S-adenosylhomocysteine deaminase activity
FXO12_RS16545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FXO12_RS16550	COG0058	SHG alpha-glucan phosphorylase activity
FXO12_RS16570	COG0301	tRNA thio-modification
FXO12_RS16570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXO12_RS16585	COG3852	Histidine kinase
FXO12_RS16605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXO12_RS16615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXO12_RS16620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FXO12_RS16625	COG4942	peptidase
FXO12_RS16630	COG0793	Belongs to the peptidase S41A family
FXO12_RS16635	COG2861	carbohydrate metabolic process
FXO12_RS16645	COG0107	imidazoleglycerol-phosphate synthase activity
FXO12_RS16650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FXO12_RS16660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FXO12_RS16665	COG0131	Imidazoleglycerol-phosphate dehydratase
FXO12_RS16680	COG1194	a g-specific adenine glycosylase
FXO12_RS16685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FXO12_RS16800	COG2957	Belongs to the agmatine deiminase family
FXO12_RS16805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FXO12_RS16845	COG1218	3'(2'),5'-bisphosphate nucleotidase
FXO12_RS16850	COG0494	nUDIX hydrolase
FXO12_RS16855	COG1011	Hydrolase
FXO12_RS16860	COG1652	LysM domain
FXO12_RS16865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FXO12_RS16870	COG0243	molybdopterin cofactor binding
FXO12_RS16885	COG0514	ATP-dependent DNA helicase (RecQ)
FXO12_RS16920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FXO12_RS16925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXO12_RS16935	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXO12_RS16940	COG2200	EAL domain
FXO12_RS16945	COG0189	ligase activity
FXO12_RS16945	COG4067	protein conserved in archaea
FXO12_RS16950	COG0189	ligase activity
FXO12_RS16960	COG0745	RESPONSE REGULATOR receiver
FXO12_RS16965	COG2183	response to ionizing radiation
FXO12_RS16975	COG2918	glutathione biosynthetic process
FXO12_RS16980	COG4521	taurine ABC transporter
FXO12_RS16985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FXO12_RS16990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXO12_RS16995	COG2175	clavaminate synthase activity
FXO12_RS17000	COG0667	Aldo Keto reductase
FXO12_RS17005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXO12_RS17010	COG1045	serine acetyltransferase
FXO12_RS17015	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FXO12_RS17060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXO12_RS17065	COG2011	ABC-type metal ion transport system permease component
FXO12_RS17085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXO12_RS17105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS17110	COG1126	abc transporter atp-binding protein
FXO12_RS17115	COG0765	amino acid transport
FXO12_RS17120	COG0765	amino acid transport
FXO12_RS17160	COG0583	DNA-binding transcription factor activity
FXO12_RS17165	COG0590	tRNA wobble adenosine to inosine editing
FXO12_RS17170	COG2807	transmembrane transport
FXO12_RS17175	COG4771	TonB-dependent receptor
FXO12_RS17205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXO12_RS17210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXO12_RS17240	COG2351	hydroxyisourate hydrolase activity
FXO12_RS17255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FXO12_RS17260	COG4208	sulfate ABC transporter
FXO12_RS17270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FXO12_RS17290	COG3706	GGDEF domain
FXO12_RS17290	COG0745	RESPONSE REGULATOR receiver
FXO12_RS17295	COG0745	RESPONSE REGULATOR receiver
FXO12_RS17300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FXO12_RS17305	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS17365	COG5002	protein histidine kinase activity
FXO12_RS17370	COG0745	RESPONSE REGULATOR receiver
FXO12_RS17400	COG1595	DNA-templated transcription, initiation
FXO12_RS17405	COG2304	oxidoreductase activity
FXO12_RS17470	COG2831	hemolysin activation secretion protein
FXO12_RS17480	COG1215	transferase activity, transferring glycosyl groups
FXO12_RS17485	COG1649	PFAM Uncharacterised BCR, COG1649
FXO12_RS17485	COG0726	polysaccharide deacetylase
FXO12_RS17490	COG0457	Tetratricopeptide repeat
FXO12_RS17495	COG5339	Protein conserved in bacteria
FXO12_RS17510	COG1566	PFAM secretion protein HlyD family protein
FXO12_RS17520	COG1289	transmembrane transporter activity
FXO12_RS17570	COG4774	siderophore transport
FXO12_RS17580	COG1595	DNA-templated transcription, initiation
FXO12_RS17600	COG0583	DNA-binding transcription factor activity
FXO12_RS17605	COG2175	clavaminate synthase activity
FXO12_RS17610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXO12_RS17615	COG2274	protein secretion by the type I secretion system
FXO12_RS17635	COG3300	MHYT domain
FXO12_RS17635	COG5001	Diguanylate cyclase
FXO12_RS17645	COG1802	Transcriptional regulator
FXO12_RS17665	COG0840	transmembrane signaling receptor activity
FXO12_RS17705	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS17710	COG0583	DNA-binding transcription factor activity
FXO12_RS17715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXO12_RS17720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXO12_RS17725	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FXO12_RS17730	COG0427	acetyl-CoA hydrolase
FXO12_RS17760	COG2851	Citrate transporter
FXO12_RS17765	COG0861	Integral membrane protein TerC family
FXO12_RS17770	COG1283	sodium-dependent phosphate transmembrane transporter activity
FXO12_RS17775	COG0612	Peptidase, M16
FXO12_RS17785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXO12_RS17790	COG1127	ABC transporter
FXO12_RS17805	COG0700	Nucleoside recognition
FXO12_RS17810	COG1301	dicarboxylic acid transport
FXO12_RS17820	COG5487	UPF0391 membrane protein
FXO12_RS17830	COG2204	response regulator
FXO12_RS17835	COG5002	protein histidine kinase activity
FXO12_RS17840	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXO12_RS17845	COG3706	GGDEF domain
FXO12_RS17845	COG0745	RESPONSE REGULATOR receiver
FXO12_RS17855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXO12_RS17865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FXO12_RS17885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FXO12_RS17890	COG0735	belongs to the Fur family
FXO12_RS17895	COG1121	(ABC) transporter
FXO12_RS17900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXO12_RS17915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXO12_RS17920	COG2011	ABC-type metal ion transport system permease component
FXO12_RS17935	COG0109	protoheme IX farnesyltransferase activity
FXO12_RS17940	COG1612	heme a metabolic process
FXO12_RS17965	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FXO12_RS17970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FXO12_RS17975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FXO12_RS17985	COG0659	secondary active sulfate transmembrane transporter activity
FXO12_RS18025	COG0339	signal peptide processing
FXO12_RS18030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FXO12_RS18055	COG1764	response to oxidative stress
FXO12_RS18060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXO12_RS18070	COG3360	Dodecin
FXO12_RS18090	COG0159	tryptophan synthase activity
FXO12_RS18100	COG2271	Major facilitator Superfamily
FXO12_RS18105	COG4948	Mandelate Racemase Muconate Lactonizing
FXO12_RS18110	COG0800	Aldolase
FXO12_RS18115	COG3734	2-keto-3-deoxy-galactonokinase
FXO12_RS18125	COG0583	DNA-binding transcription factor activity
FXO12_RS18130	COG3119	arylsulfatase activity
FXO12_RS18145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXO12_RS18150	COG0408	coproporphyrinogen oxidase activity
FXO12_RS18160	COG0009	L-threonylcarbamoyladenylate synthase
FXO12_RS18165	COG0758	DNA mediated transformation
FXO12_RS18175	COG0242	peptide deformylase activity
FXO12_RS18180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FXO12_RS18185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXO12_RS18190	COG0569	domain protein
FXO12_RS18205	COG2818	Glycosylase
FXO12_RS18210	COG0752	glycyl-tRNA synthetase alpha subunit
FXO12_RS18215	COG0751	glycine-tRNA ligase activity
FXO12_RS18220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FXO12_RS18230	COG5002	protein histidine kinase activity
FXO12_RS18235	COG0745	RESPONSE REGULATOR receiver
FXO12_RS18240	COG0187	DNA topoisomerase II activity
FXO12_RS18245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FXO12_RS18250	COG0592	DNA-directed DNA polymerase activity
FXO12_RS18255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXO12_RS18260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FXO12_RS18265	COG0594	ribonuclease P activity
FXO12_RS18270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FXO12_RS18275	COG0706	membrane insertase activity
FXO12_RS18280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FXO12_RS18290	COG3712	iron ion homeostasis
FXO12_RS18295	COG1595	DNA-templated transcription, initiation
FXO12_RS18300	COG0445	tRNA wobble uridine modification
FXO12_RS18305	COG0357	Ribosomal RNA small subunit methyltransferase G
FXO12_RS18310	COG1192	Involved in chromosome partitioning
FXO12_RS18315	COG1475	DNA binding
FXO12_RS18320	COG3312	ion transport
FXO12_RS18325	COG0356	it plays a direct role in the translocation of protons across the membrane
FXO12_RS18335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FXO12_RS18340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXO12_RS18345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FXO12_RS18350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FXO12_RS18355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FXO12_RS18360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FXO12_RS18365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXO12_RS18370	COG1349	DNA-binding transcription factor activity
FXO12_RS18375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXO12_RS18385	COG4589	Belongs to the CDS family
FXO12_RS18400	COG0671	phosphoesterase, PA-phosphatase related
FXO12_RS18400	COG2453	phosphatase
FXO12_RS18405	COG2267	carboxylic ester hydrolase activity
FXO12_RS18410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXO12_RS18445	COG3220	belongs to the UPF0276 family
FXO12_RS18455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FXO12_RS18460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXO12_RS18470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FXO12_RS18490	COG1121	(ABC) transporter
FXO12_RS18495	COG1469	GTP cyclohydrolase I activity
FXO12_RS18500	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXO12_RS18510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXO12_RS18525	COG0523	cobalamin synthesis protein
FXO12_RS18535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FXO12_RS18540	COG1607	acyl-coa hydrolase
FXO12_RS18545	COG4651	solute:proton antiporter activity
FXO12_RS18545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FXO12_RS18560	COG0210	DNA helicase
FXO12_RS18565	COG3300	MHYT domain
FXO12_RS18565	COG5001	Diguanylate cyclase
FXO12_RS18580	COG0583	DNA-binding transcription factor activity
FXO12_RS18585	COG0439	Biotin carboxylase
FXO12_RS18590	COG0511	ligase activity, forming carbon-carbon bonds
FXO12_RS18590	COG5016	pyruvate
FXO12_RS18605	COG3468	outer membrane autotransporter barrel domain protein
FXO12_RS18610	COG0765	amino acid transport
FXO12_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS18670	COG0252	asparaginase activity
FXO12_RS18675	COG1115	amino acid carrier protein
FXO12_RS18680	COG1027	Aspartate ammonia-lyase
FXO12_RS18685	COG0583	DNA-binding transcription factor activity
FXO12_RS18715	COG1607	acyl-coa hydrolase
FXO12_RS18720	COG0477	Major facilitator Superfamily
FXO12_RS18735	COG0573	inorganic phosphate transmembrane transporter activity
FXO12_RS18740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FXO12_RS18745	COG0704	Plays a role in the regulation of phosphate uptake
FXO12_RS18755	COG1253	flavin adenine dinucleotide binding
FXO12_RS18775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FXO12_RS18780	COG3161	chorismate lyase activity
FXO12_RS18830	COG3209	COG3209 Rhs family protein
FXO12_RS18840	COG3501	Rhs element vgr protein
FXO12_RS18915	COG0631	protein serine/threonine phosphatase activity
FXO12_RS18920	COG0515	serine threonine protein kinase
FXO12_RS18920	COG2815	serine threonine protein kinase
FXO12_RS18925	COG1136	(ABC) transporter
FXO12_RS18925	COG0577	efflux transmembrane transporter activity
FXO12_RS18955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FXO12_RS18960	COG0583	DNA-binding transcription factor activity
FXO12_RS18970	COG0848	biopolymer transport protein
FXO12_RS18995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXO12_RS19000	COG1758	RNA polymerase activity
FXO12_RS19005	COG0194	GDP metabolic process
FXO12_RS19010	COG1561	YicC-like family, N-terminal region
FXO12_RS19015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FXO12_RS19025	COG0708	Exodeoxyribonuclease III
FXO12_RS19030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FXO12_RS19035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FXO12_RS19040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXO12_RS19050	COG0756	dUTP diphosphatase activity
FXO12_RS19055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXO12_RS19060	COG2003	Belongs to the UPF0758 family
FXO12_RS19065	COG0747	negative chemotaxis
FXO12_RS19070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FXO12_RS19075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FXO12_RS19085	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS19095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXO12_RS19100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXO12_RS19110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS19120	COG1522	sequence-specific DNA binding
FXO12_RS19125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS19135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FXO12_RS19150	COG0427	acetyl-CoA hydrolase
FXO12_RS19155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FXO12_RS19170	COG0534	Mate efflux family protein
FXO12_RS19175	COG0583	DNA-binding transcription factor activity
FXO12_RS19195	COG0606	chelatase, subunit chli
FXO12_RS19205	COG0347	Belongs to the P(II) protein family
FXO12_RS19210	COG0004	ammonium transporteR
FXO12_RS19215	COG0432	Pfam Uncharacterised protein family UPF0047
FXO12_RS19225	COG1011	Hydrolase
FXO12_RS19230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXO12_RS19240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXO12_RS19245	COG0019	diaminopimelate decarboxylase activity
FXO12_RS19255	COG1965	Belongs to the frataxin family
FXO12_RS19265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXO12_RS19285	COG0625	glutathione transferase activity
FXO12_RS19290	COG0165	Argininosuccinate lyase
FXO12_RS19300	COG0181	hydroxymethylbilane synthase activity
FXO12_RS19320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FXO12_RS19345	COG0488	(ABC) transporter
FXO12_RS19355	COG1280	lysine exporter protein (LysE YggA)
FXO12_RS19360	COG0672	)-iron permease
FXO12_RS19365	COG1671	Belongs to the UPF0178 family
FXO12_RS19370	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FXO12_RS19380	COG0586	Pfam SNARE associated Golgi protein
FXO12_RS19390	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FXO12_RS19395	COG0248	Ppx GppA phosphatase
FXO12_RS19410	COG3121	Chaperone
FXO12_RS19415	COG3188	usher protein
FXO12_RS19425	COG1126	abc transporter atp-binding protein
FXO12_RS19435	COG0765	amino acid transport
FXO12_RS19440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS19445	COG2186	Transcriptional regulator
FXO12_RS19465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FXO12_RS19485	COG2271	Major facilitator Superfamily
FXO12_RS19505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXO12_RS19525	COG3079	Belongs to the UPF0149 family
FXO12_RS19530	COG0006	proline dipeptidase activity
FXO12_RS19535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXO12_RS19545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXO12_RS19555	COG1178	ABC-type Fe3 transport system permease component
FXO12_RS19560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXO12_RS19565	COG0509	glycine decarboxylation via glycine cleavage system
FXO12_RS19570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FXO12_RS19590	COG1522	sequence-specific DNA binding
FXO12_RS19605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FXO12_RS19605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FXO12_RS19610	COG4521	taurine ABC transporter
FXO12_RS19620	COG0450	alkyl hydroperoxide reductase
FXO12_RS19625	COG0431	NADPH-dependent FMN reductase
FXO12_RS19630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXO12_RS19640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXO12_RS19645	COG1116	anion transmembrane transporter activity
FXO12_RS19660	COG0174	glutamine synthetase
FXO12_RS19665	COG0174	glutamine synthetase
FXO12_RS19685	COG3842	ATPase activity
FXO12_RS19690	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXO12_RS19695	COG1177	transmembrane transport
FXO12_RS19710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXO12_RS19715	COG4977	sequence-specific DNA binding
FXO12_RS19715	COG1917	Cupin 2, conserved barrel domain protein
FXO12_RS19745	COG1683	Conserved Protein
FXO12_RS19750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS19760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXO12_RS19765	COG0277	FAD linked oxidase domain protein
FXO12_RS19770	COG0179	Fumarylacetoacetate (FAA) hydrolase
FXO12_RS19780	COG3204	pilus organization
FXO12_RS19785	COG2234	aminopeptidase activity
FXO12_RS19790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXO12_RS19795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FXO12_RS19810	COG0494	nUDIX hydrolase
FXO12_RS19815	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
FXO12_RS19825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FXO12_RS19830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FXO12_RS19835	COG0789	Transcriptional regulator
FXO12_RS19845	COG0583	DNA-binding transcription factor activity
FXO12_RS19850	COG3842	ATPase activity
FXO12_RS19855	COG1178	ABC-type Fe3 transport system permease component
FXO12_RS19860	COG1840	ABC-type Fe3 transport system, periplasmic component
FXO12_RS19870	COG1160	GTP binding
FXO12_RS19910	COG0129	dihydroxy-acid dehydratase activity
FXO12_RS19915	COG2814	Major facilitator Superfamily
FXO12_RS19920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXO12_RS19930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FXO12_RS19935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXO12_RS19940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FXO12_RS19945	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FXO12_RS19960	COG1309	transcriptional regulator
FXO12_RS19970	COG0429	hydrolase of the alpha beta-hydrolase fold
FXO12_RS19975	COG0742	ribosomal rna small subunit methyltransferase
FXO12_RS19980	COG0612	Peptidase, M16
FXO12_RS19985	COG0612	Peptidase, M16
FXO12_RS19990	COG0552	protein localization to endoplasmic reticulum
FXO12_RS19995	COG2884	Cell division ATP-binding protein ftsE
FXO12_RS20000	COG2177	Part of the ABC transporter FtsEX involved in
FXO12_RS20010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXO12_RS20015	COG2363	Small membrane protein
FXO12_RS20025	COG2022	thiamine diphosphate biosynthetic process
FXO12_RS20030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FXO12_RS20040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXO12_RS20045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXO12_RS20055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXO12_RS20055	COG2813	Specifically methylates the guanine in position
FXO12_RS20060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXO12_RS20085	COG0791	NLP P60 protein
FXO12_RS20095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FXO12_RS20100	COG0540	Belongs to the ATCase OTCase family
FXO12_RS20105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FXO12_RS20110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FXO12_RS20115	COG1678	Uncharacterized ACR, COG1678
FXO12_RS20125	COG0189	ligase activity
FXO12_RS20165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FXO12_RS20170	COG3052	prosthetic group binding
FXO12_RS20190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FXO12_RS20210	COG1272	protein, Hemolysin III
FXO12_RS20230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS20235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FXO12_RS20245	COG3038	cytochrome b561
FXO12_RS20250	COG2353	YceI-like domain
FXO12_RS20255	COG0513	Belongs to the DEAD box helicase family
FXO12_RS20270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXO12_RS20275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FXO12_RS20285	COG2116	formate transmembrane transporter activity
FXO12_RS20340	COG3237	CsbD-like
FXO12_RS20415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FXO12_RS20420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXO12_RS20430	COG0589	response to stress
FXO12_RS20435	COG0659	secondary active sulfate transmembrane transporter activity
FXO12_RS20450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXO12_RS20455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXO12_RS20465	COG4325	translation initiation factor activity
FXO12_RS20515	COG1422	Protein of unknown function (DUF1090)
FXO12_RS20520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FXO12_RS20530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FXO12_RS20535	COG0640	Transcriptional regulator
FXO12_RS20540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FXO12_RS20545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXO12_RS20550	COG0126	phosphoglycerate kinase activity
FXO12_RS20580	COG1451	nucleotide metabolic process
FXO12_RS20590	COG2153	protein acetylation
FXO12_RS20600	COG1289	transmembrane transporter activity
FXO12_RS20605	COG2081	HI0933 family
FXO12_RS20610	COG0513	Belongs to the DEAD box helicase family
FXO12_RS20615	COG0477	Major facilitator Superfamily
FXO12_RS20635	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FXO12_RS20640	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS20645	COG1309	transcriptional regulator
FXO12_RS20650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXO12_RS20655	COG4175	Glycine betaine
FXO12_RS20670	COG1760	l-serine dehydratase
FXO12_RS20690	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXO12_RS20695	COG3246	L-lysine catabolic process to acetate
FXO12_RS20745	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS20745	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXO12_RS20750	COG2181	nitrate reductase activity
FXO12_RS20750	COG0247	lactate metabolic process
FXO12_RS20755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FXO12_RS20765	COG4638	Rieske (2fe-2S)
FXO12_RS20770	COG1017	nitric oxide dioxygenase activity
FXO12_RS20770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXO12_RS20795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXO12_RS20825	COG1063	alcohol dehydrogenase
FXO12_RS20840	COG0577	efflux transmembrane transporter activity
FXO12_RS20840	COG1136	(ABC) transporter
FXO12_RS20845	COG0577	efflux transmembrane transporter activity
FXO12_RS20845	COG1136	(ABC) transporter
FXO12_RS20870	COG0204	Acyl-transferase
FXO12_RS20875	COG0189	ligase activity
FXO12_RS20875	COG4067	protein conserved in archaea
FXO12_RS20880	COG0745	RESPONSE REGULATOR receiver
FXO12_RS20885	COG2205	protein histidine kinase activity
FXO12_RS20890	COG4452	Inner membrane protein CreD
FXO12_RS20950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FXO12_RS20975	COG1426	Protein conserved in bacteria
FXO12_RS21025	COG4373	Mu-like prophage FluMu protein gp28
FXO12_RS21035	COG2369	cell adhesion
FXO12_RS21160	COG3712	iron ion homeostasis
FXO12_RS21165	COG1595	DNA-templated transcription, initiation
FXO12_RS21170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXO12_RS21180	COG0745	RESPONSE REGULATOR receiver
FXO12_RS21180	COG4566	intracellular signal transduction
FXO12_RS21185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FXO12_RS21200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FXO12_RS21210	COG2005	Transcriptional regulator
FXO12_RS21210	COG3585	molybdate ion transport
FXO12_RS21220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FXO12_RS21225	COG0156	8-amino-7-oxononanoate synthase activity
FXO12_RS21230	COG2226	methyltransferase
FXO12_RS21230	COG1073	alpha beta
FXO12_RS21250	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS21255	COG3706	GGDEF domain
FXO12_RS21260	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS21265	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS21270	COG0583	DNA-binding transcription factor activity
FXO12_RS21275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FXO12_RS21285	COG0535	radical SAM domain protein
FXO12_RS21295	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FXO12_RS21300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FXO12_RS21310	COG1025	Belongs to the peptidase M16 family
FXO12_RS21315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXO12_RS21385	COG0640	Transcriptional regulator
FXO12_RS21390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FXO12_RS21395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXO12_RS21400	COG0431	NADPH-dependent FMN reductase
FXO12_RS21410	COG2072	flavoprotein involved in K transport
FXO12_RS21425	COG0659	secondary active sulfate transmembrane transporter activity
FXO12_RS21430	COG0589	response to stress
FXO12_RS21440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXO12_RS21445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FXO12_RS21500	COG2217	Heavy metal translocating P-type atpase
FXO12_RS21580	COG1238	metal cluster binding
FXO12_RS21590	COG2814	Major facilitator Superfamily
FXO12_RS21630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXO12_RS21715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXO12_RS21750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXO12_RS21755	COG0358	DNA primase activity
FXO12_RS21760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FXO12_RS21765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FXO12_RS21770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FXO12_RS21775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXO12_RS21785	COG0617	tRNA 3'-terminal CCA addition
FXO12_RS21790	COG2719	SpoVR family
FXO12_RS21795	COG2718	Belongs to the UPF0229 family
FXO12_RS21800	COG2766	serine protein kinase
FXO12_RS21805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXO12_RS21810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXO12_RS21815	COG2967	ApaG domain
FXO12_RS21820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXO12_RS21825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FXO12_RS21830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXO12_RS21835	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXO12_RS21840	COG3178	'Phosphotransferase
FXO12_RS21845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FXO12_RS21850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FXO12_RS21860	COG1454	alcohol dehydrogenase
FXO12_RS21865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FXO12_RS21870	COG0546	phosphoglycolate phosphatase activity
FXO12_RS21875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXO12_RS21880	COG4625	pathogenesis
FXO12_RS21880	COG3240	lipase activity
FXO12_RS21885	COG0512	Glutamine amidotransferase of anthranilate synthase
FXO12_RS21890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FXO12_RS21895	COG0134	indole-3-glycerol-phosphate synthase activity
FXO12_RS21910	COG1765	OsmC-like protein
FXO12_RS21915	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FXO12_RS21920	COG0537	adenosine 5'-monophosphoramidase activity
FXO12_RS21925	COG4221	oxidoreductase activity
FXO12_RS21945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FXO12_RS21950	COG0316	Belongs to the HesB IscA family
FXO12_RS21955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FXO12_RS21960	COG0739	heme binding
FXO12_RS21965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FXO12_RS22005	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FXO12_RS22045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FXO12_RS22050	COG0081	regulation of translation
FXO12_RS22055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXO12_RS22060	COG0222	ribosome binding
FXO12_RS22065	COG0085	RNA polymerase activity
FXO12_RS22070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FXO12_RS22075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXO12_RS22080	COG0049	tRNA binding
FXO12_RS22085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FXO12_RS22090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXO12_RS22095	COG0051	transcription antitermination factor activity, RNA binding
FXO12_RS22100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXO12_RS22105	COG0088	Forms part of the polypeptide exit tunnel
FXO12_RS22110	COG0089	rRNA binding
FXO12_RS22115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXO12_RS22120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FXO12_RS22130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXO12_RS22135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FXO12_RS22140	COG0255	Belongs to the universal ribosomal protein uL29 family
FXO12_RS22145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXO12_RS22150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FXO12_RS22155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FXO12_RS22160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FXO12_RS22165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FXO12_RS22170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXO12_RS22175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FXO12_RS22180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FXO12_RS22185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FXO12_RS22190	COG1841	ribosomal large subunit assembly
FXO12_RS22195	COG0200	Binds to the 23S rRNA
FXO12_RS22205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FXO12_RS22210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FXO12_RS22215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FXO12_RS22220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXO12_RS22225	COG0202	RNA polymerase activity
FXO12_RS22230	COG0203	ribosomal protein L17
FXO12_RS22240	COG2193	ferroxidase activity
FXO12_RS22245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXO12_RS22250	COG2814	Major facilitator Superfamily
FXO12_RS22255	COG0629	single-stranded DNA binding
FXO12_RS22260	COG4106	trans-aconitate 2-methyltransferase activity
FXO12_RS22265	COG1335	isochorismatase
FXO12_RS22270	COG4753	response regulator
FXO12_RS22270	COG2207	Transcriptional regulator
FXO12_RS22285	COG0392	lysyltransferase activity
FXO12_RS22290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXO12_RS22295	COG3568	Endonuclease Exonuclease Phosphatase
FXO12_RS22305	COG0668	transmembrane transport
FXO12_RS22310	COG1201	RNA secondary structure unwinding
FXO12_RS22350	COG3118	belongs to the thioredoxin family
FXO12_RS22355	COG2264	protein methyltransferase activity
FXO12_RS22365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXO12_RS22370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXO12_RS22370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXO12_RS22385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXO12_RS22390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXO12_RS22395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FXO12_RS22405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXO12_RS22415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXO12_RS22420	COG4206	TonB-dependent receptor
FXO12_RS22425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FXO12_RS22430	COG0142	geranyltranstransferase activity
FXO12_RS22435	COG1722	exodeoxyribonuclease VII activity
FXO12_RS22445	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXO12_RS22450	COG4804	nuclease activity
FXO12_RS22460	COG1842	Phage shock protein A
FXO12_RS22480	COG3766	membrane
FXO12_RS22490	COG0754	glutathionylspermidine amidase activity
FXO12_RS22495	COG1335	isochorismatase
FXO12_RS22505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FXO12_RS22510	COG3228	Belongs to the MtfA family
FXO12_RS22515	COG0586	Pfam SNARE associated Golgi protein
FXO12_RS22520	COG0456	acetyltransferase
FXO12_RS22525	COG4302	ethanolamine ammonia-lyase activity
FXO12_RS22530	COG4303	Ethanolamine ammonia lyase large subunit
FXO12_RS22535	COG0531	amino acid
FXO12_RS22540	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS22545	COG3284	Transcriptional regulator
FXO12_RS22550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXO12_RS22565	COG0702	epimerase
FXO12_RS22580	COG1380	Effector of murein hydrolase LrgA
FXO12_RS22585	COG1346	cytolysis
FXO12_RS22635	COG2246	polysaccharide biosynthetic process
FXO12_RS22680	COG0586	Pfam SNARE associated Golgi protein
FXO12_RS22685	COG2094	Belongs to the DNA glycosylase MPG family
FXO12_RS22690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FXO12_RS22695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FXO12_RS22705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FXO12_RS22710	COG0768	penicillin binding
FXO12_RS22715	COG0772	Belongs to the SEDS family
FXO12_RS22720	COG2951	lytic endotransglycosylase activity
FXO12_RS22730	COG1686	Belongs to the peptidase S11 family
FXO12_RS22735	COG2921	Belongs to the UPF0250 family
FXO12_RS22740	COG0321	lipoyl(octanoyl) transferase activity
FXO12_RS22745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FXO12_RS22750	COG1619	proteins homologs of microcin C7 resistance protein MccF
FXO12_RS22755	COG2951	lytic endotransglycosylase activity
FXO12_RS22765	COG1466	dna polymerase III delta subunit
FXO12_RS22775	COG0495	leucyl-tRNA aminoacylation
FXO12_RS22790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FXO12_RS22795	COG4535	Mg2 and Co2 transporter CorC
FXO12_RS22800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXO12_RS22805	COG1702	phosphate starvation-inducible protein PhoH
FXO12_RS22810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXO12_RS22825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXO12_RS22830	COG0352	thiamine-phosphate diphosphorylase activity
FXO12_RS22845	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS22850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FXO12_RS22865	COG1522	sequence-specific DNA binding
FXO12_RS22875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FXO12_RS22885	COG1643	Atp-dependent helicase
FXO12_RS22890	COG3622	Belongs to the hyi family
FXO12_RS22905	COG3416	Protein conserved in bacteria
FXO12_RS22915	COG1199	ATP-dependent helicase activity
FXO12_RS22915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXO12_RS22930	COG1522	sequence-specific DNA binding
FXO12_RS22935	COG0697	spore germination
FXO12_RS22940	COG0513	Belongs to the DEAD box helicase family
FXO12_RS22955	COG0123	including yeast histone deacetylase and acetoin utilization protein
FXO12_RS22965	COG1946	Acyl-CoA thioesterase
FXO12_RS22980	COG2321	neutral zinc metallopeptidase
FXO12_RS22995	COG0477	Major facilitator Superfamily
FXO12_RS23005	COG1309	transcriptional regulator
FXO12_RS23010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXO12_RS23015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FXO12_RS23035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXO12_RS23040	COG2252	PERMEase
FXO12_RS23050	COG2080	2 iron, 2 sulfur cluster binding
FXO12_RS23055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FXO12_RS23060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXO12_RS23070	COG1271	oxidase subunit
FXO12_RS23075	COG1294	oxidase, subunit
FXO12_RS23085	COG2813	Specifically methylates the guanine in position
FXO12_RS23100	COG1970	mechanosensitive ion channel activity
FXO12_RS23125	COG1966	Carbon starvation protein
FXO12_RS23130	COG2879	small protein
FXO12_RS23135	COG0523	cobalamin synthesis protein
FXO12_RS23140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXO12_RS23150	COG0488	(ABC) transporter
FXO12_RS23155	COG0583	DNA-binding transcription factor activity
FXO12_RS23160	COG2814	Major facilitator Superfamily
FXO12_RS23185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FXO12_RS23195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXO12_RS23215	COG1067	ATP-dependent peptidase activity
FXO12_RS23230	COG2862	Uncharacterized protein family, UPF0114
FXO12_RS23295	COG3311	Transcriptional regulator
FXO12_RS23310	COG0582	viral genome integration into host DNA
FXO12_RS23330	COG1620	l-lactate permease
FXO12_RS23335	COG2186	Transcriptional regulator
FXO12_RS23340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FXO12_RS23350	COG2914	Belongs to the UPF0125 (RnfH) family
FXO12_RS23355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXO12_RS23360	COG0735	belongs to the Fur family
FXO12_RS23365	COG0497	DNA recombination
FXO12_RS23370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXO12_RS23375	COG0443	Heat shock 70 kDa protein
FXO12_RS23380	COG0484	heat shock protein binding
FXO12_RS23385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FXO12_RS23390	COG0505	Belongs to the CarA family
FXO12_RS23395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FXO12_RS23400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXO12_RS23415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FXO12_RS23420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FXO12_RS23425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXO12_RS23430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXO12_RS23435	COG0149	triose-phosphate isomerase activity
FXO12_RS23440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXO12_RS23455	COG0779	Required for maturation of 30S ribosomal subunits
FXO12_RS23460	COG0195	Participates in both transcription termination and antitermination
FXO12_RS23465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FXO12_RS23470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXO12_RS23475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FXO12_RS23480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FXO12_RS23485	COG1185	polyribonucleotide nucleotidyltransferase activity
FXO12_RS23490	COG2823	Periplasmic or secreted lipoprotein
FXO12_RS23500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXO12_RS23505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXO12_RS23510	COG0166	Belongs to the GPI family
FXO12_RS23515	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FXO12_RS23520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FXO12_RS23540	COG4191	Histidine kinase
FXO12_RS23550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXO12_RS23555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXO12_RS23565	COG1489	DNA binding
FXO12_RS23575	COG4558	Periplasmic binding protein
FXO12_RS23580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXO12_RS23585	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FXO12_RS23605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXO12_RS23615	COG3098	single-species biofilm formation
FXO12_RS23620	COG0028	Belongs to the TPP enzyme family
FXO12_RS23630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FXO12_RS23635	COG1183	phosphatidylcholine synthase activity
FXO12_RS23640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FXO12_RS23645	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FXO12_RS23675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FXO12_RS23680	COG1074	ATP-dependent DNA helicase activity
FXO12_RS23685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXO12_RS23720	COG0583	DNA-binding transcription factor activity
FXO12_RS23745	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FXO12_RS23750	COG3483	tryptophan 2,3-dioxygenase activity
FXO12_RS23755	COG1113	amino acid transport
FXO12_RS23760	COG0543	2 iron, 2 sulfur cluster binding
FXO12_RS23760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXO12_RS23765	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FXO12_RS23770	COG4638	Rieske (2fe-2S)
FXO12_RS23785	COG4948	Mandelate Racemase Muconate Lactonizing
FXO12_RS23790	COG4829	muconolactone delta-isomerase
FXO12_RS23795	COG3485	protocatechuate 3,4-dioxygenase
FXO12_RS23800	COG1522	sequence-specific DNA binding
FXO12_RS23810	COG1113	amino acid transport
FXO12_RS23815	COG0583	DNA-binding transcription factor activity
FXO12_RS23825	COG0583	DNA-binding transcription factor activity
FXO12_RS23835	COG0659	secondary active sulfate transmembrane transporter activity
FXO12_RS23845	COG2610	gluconate transmembrane transporter activity
FXO12_RS23855	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FXO12_RS23870	COG0840	transmembrane signaling receptor activity
FXO12_RS23875	COG0545	Peptidyl-prolyl cis-trans isomerase
FXO12_RS23880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXO12_RS23885	COG2824	Alkylphosphonate utilization operon protein PhnA
FXO12_RS23890	COG0142	geranyltranstransferase activity
FXO12_RS23895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FXO12_RS23900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FXO12_RS23905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FXO12_RS23910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FXO12_RS23915	COG3045	CreA protein
FXO12_RS23920	COG0386	Belongs to the glutathione peroxidase family
FXO12_RS23935	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FXO12_RS23940	COG0492	ferredoxin-NADP+ reductase activity
FXO12_RS23955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXO12_RS23985	COG1366	Belongs to the anti-sigma-factor antagonist family
FXO12_RS24005	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS24025	COG2197	response regulator
FXO12_RS24030	COG3708	Transcriptional regulator
FXO12_RS24030	COG2207	Transcriptional regulator
FXO12_RS24040	COG3604	Transcriptional regulator
FXO12_RS24045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXO12_RS24045	COG1017	nitric oxide dioxygenase activity
FXO12_RS24050	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FXO12_RS24055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FXO12_RS24060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FXO12_RS24075	COG0109	protoheme IX farnesyltransferase activity
FXO12_RS24080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXO12_RS24095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXO12_RS24135	COG4251	negative regulation of phosphorylation
FXO12_RS24175	COG3311	Transcriptional regulator
FXO12_RS24180	COG1569	PIN domain
FXO12_RS24190	COG1280	lysine exporter protein (LysE YggA)
FXO12_RS24205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FXO12_RS24210	COG0343	queuine tRNA-ribosyltransferase activity
FXO12_RS24215	COG1862	Preprotein translocase
FXO12_RS24230	COG3134	Outer membrane lipoprotein
FXO12_RS24255	COG1104	cysteine desulfurase activity
FXO12_RS24265	COG0316	Belongs to the HesB IscA family
FXO12_RS24270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FXO12_RS24275	COG0443	Heat shock 70 kDa protein
FXO12_RS24280	COG0633	Ferredoxin
FXO12_RS24290	COG0105	UTP biosynthetic process
FXO12_RS24295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FXO12_RS24305	COG1426	Protein conserved in bacteria
FXO12_RS24310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FXO12_RS24315	COG0124	histidyl-tRNA synthetase
FXO12_RS24330	COG1160	GTP binding
FXO12_RS24335	COG0436	Aminotransferase
FXO12_RS24340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXO12_RS24345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FXO12_RS24360	COG0739	heme binding
FXO12_RS24365	COG1570	exodeoxyribonuclease VII activity
FXO12_RS24370	COG0583	DNA-binding transcription factor activity
FXO12_RS24390	COG0519	Catalyzes the synthesis of GMP from XMP
FXO12_RS24390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FXO12_RS24400	COG2188	Transcriptional regulator
FXO12_RS24405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXO12_RS24405	COG1263	PTS System
FXO12_RS24410	COG0366	Alpha amylase catalytic
FXO12_RS24415	COG4580	involved in the transport of maltose and maltodextrins
FXO12_RS24420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXO12_RS24420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FXO12_RS24425	COG2190	(PTS) system
FXO12_RS24425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXO12_RS24425	COG1263	PTS System
FXO12_RS24430	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXO12_RS24435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FXO12_RS24435	COG0047	phosphoribosylformylglycinamidine synthase activity
FXO12_RS24440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FXO12_RS24450	COG2190	(PTS) system
FXO12_RS24450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXO12_RS24450	COG1263	PTS System
FXO12_RS24455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FXO12_RS24455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXO12_RS24460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXO12_RS24465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FXO12_RS24470	COG2188	Transcriptional regulator
FXO12_RS24485	COG0494	nUDIX hydrolase
FXO12_RS24505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FXO12_RS24510	COG0477	Major facilitator Superfamily
FXO12_RS24515	COG4536	flavin adenine dinucleotide binding
FXO12_RS24525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXO12_RS24530	COG0228	four-way junction DNA binding
FXO12_RS24535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FXO12_RS24540	COG0336	Belongs to the RNA methyltransferase TrmD family
FXO12_RS24545	COG0335	large ribosomal subunit rRNA binding
FXO12_RS24550	COG1607	acyl-coa hydrolase
FXO12_RS24555	COG3263	regulation of cellular component size
FXO12_RS24560	COG4974	Belongs to the 'phage' integrase family
FXO12_RS24580	COG2205	protein histidine kinase activity
FXO12_RS24580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS24590	COG2197	response regulator
FXO12_RS24600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXO12_RS24605	COG4681	YaeQ
FXO12_RS24635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXO12_RS24645	COG0442	prolyl-tRNA aminoacylation
FXO12_RS24650	COG2211	Major facilitator Superfamily
FXO12_RS24675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXO12_RS24680	COG0459	protein refolding
FXO12_RS24690	COG1368	sulfuric ester hydrolase activity
FXO12_RS24710	COG3642	lipopolysaccharide core region biosynthetic process
FXO12_RS24740	COG0840	transmembrane signaling receptor activity
FXO12_RS24745	COG2832	Protein of unknown function (DUF454)
FXO12_RS24760	COG3712	iron ion homeostasis
FXO12_RS24785	COG0745	RESPONSE REGULATOR receiver
FXO12_RS24790	COG2205	protein histidine kinase activity
FXO12_RS24795	COG2207	Transcriptional regulator
FXO12_RS24820	COG0477	Major facilitator Superfamily
FXO12_RS24830	COG4191	Histidine kinase
FXO12_RS24845	COG0469	pyruvate kinase activity
FXO12_RS24865	COG0714	Associated with various cellular activities
FXO12_RS24900	COG2246	polysaccharide biosynthetic process
FXO12_RS24970	COG2925	Exonuclease
FXO12_RS24980	COG0788	formyltetrahydrofolate deformylase activity
FXO12_RS24995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXO12_RS24995	COG0438	transferase activity, transferring glycosyl groups
FXO12_RS25005	COG0433	COG0433 Predicted ATPase
FXO12_RS25020	COG0653	protein targeting
FXO12_RS25025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FXO12_RS25035	COG2096	Adenosyltransferase
FXO12_RS25040	COG4191	Histidine kinase
FXO12_RS25040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS25050	COG1666	GTP binding
FXO12_RS25055	COG0668	transmembrane transport
FXO12_RS25070	COG2900	Belongs to the SlyX family
FXO12_RS25080	COG0783	Belongs to the Dps family
FXO12_RS25095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FXO12_RS25100	COG0217	transcriptional regulatory protein
FXO12_RS25105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FXO12_RS25110	COG0632	four-way junction helicase activity
FXO12_RS25115	COG2255	four-way junction helicase activity
FXO12_RS25120	COG0824	Thioesterase
FXO12_RS25140	COG0823	Involved in the tonB-independent uptake of proteins
FXO12_RS25145	COG2885	chlorophyll binding
FXO12_RS25150	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FXO12_RS25155	COG0602	queuosine metabolic process
FXO12_RS25200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FXO12_RS25260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FXO12_RS25270	COG1278	Cold shock
FXO12_RS25275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXO12_RS25280	COG1760	l-serine dehydratase
FXO12_RS25285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXO12_RS25285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXO12_RS25290	COG0509	glycine decarboxylation via glycine cleavage system
FXO12_RS25335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXO12_RS25340	COG0642	Histidine kinase
FXO12_RS25350	COG0745	RESPONSE REGULATOR receiver
FXO12_RS25355	COG2350	Protein conserved in bacteria
FXO12_RS25360	COG2917	probably involved in intracellular septation
FXO12_RS25365	COG0613	PHP domain protein
FXO12_RS25370	COG0009	L-threonylcarbamoyladenylate synthase
FXO12_RS25380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FXO12_RS25400	COG1113	amino acid transport
FXO12_RS25440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXO12_RS25455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FXO12_RS25465	COG0583	DNA-binding transcription factor activity
FXO12_RS25470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXO12_RS25485	COG1653	transport
FXO12_RS25495	COG0395	ABC-type sugar transport system, permease component
FXO12_RS25510	COG0676	glucose-6-phosphate 1-epimerase activity
FXO12_RS25515	COG1737	Transcriptional regulator
FXO12_RS25530	COG0800	Aldolase
FXO12_RS25535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FXO12_RS25540	COG3530	Putative quorum-sensing-regulated virulence factor
FXO12_RS25550	COG2030	dehydratase
FXO12_RS25555	COG2267	carboxylic ester hydrolase activity
FXO12_RS25560	COG0318	PFAM AMP-dependent synthetase and ligase
FXO12_RS25565	COG0318	PFAM AMP-dependent synthetase and ligase
FXO12_RS25575	COG3237	CsbD-like
FXO12_RS25580	COG1295	ribonuclease BN
FXO12_RS25585	COG0242	peptide deformylase activity
FXO12_RS25610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXO12_RS25625	COG2271	Major facilitator Superfamily
FXO12_RS25635	COG1609	Transcriptional regulator
FXO12_RS25640	COG3265	gluconokinase activity
FXO12_RS25650	COG0436	Aminotransferase
FXO12_RS25670	COG3795	YCII-related domain
FXO12_RS25680	COG4941	Belongs to the sigma-70 factor family
FXO12_RS25685	COG0583	DNA-binding transcription factor activity
FXO12_RS25695	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS25700	COG0583	DNA-binding transcription factor activity
FXO12_RS25710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FXO12_RS25720	COG1984	allophanate hydrolase subunit 2
FXO12_RS25735	COG0584	glycerophosphoryl diester phosphodiesterase
FXO12_RS25745	COG2329	Antibiotic biosynthesis monooxygenase
FXO12_RS25750	COG0504	CTP synthase activity
FXO12_RS25780	COG0154	amidase activity
FXO12_RS25795	COG2814	Major facilitator Superfamily
FXO12_RS25810	COG0765	amino acid transport
FXO12_RS25815	COG0165	Argininosuccinate lyase
FXO12_RS25825	COG0560	Phosphoserine phosphatase
FXO12_RS25850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXO12_RS25865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXO12_RS25870	COG4215	(ABC) transporter
FXO12_RS25900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FXO12_RS25915	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS25920	COG3724	N-succinylarginine dihydrolase activity
FXO12_RS25930	COG2988	succinylglutamate desuccinylase activity
FXO12_RS25940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXO12_RS25945	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FXO12_RS25950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FXO12_RS25955	COG0527	aspartate kinase activity
FXO12_RS25960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXO12_RS25980	COG2239	Acts as a magnesium transporter
FXO12_RS26030	COG0477	Major facilitator Superfamily
FXO12_RS26035	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
FXO12_RS26055	COG0784	Response regulator, receiver
FXO12_RS26055	COG0835	chemotaxis
FXO12_RS26060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FXO12_RS26065	COG1815	bacterial-type flagellum-dependent cell motility
FXO12_RS26070	COG1558	bacterial-type flagellum-dependent cell motility
FXO12_RS26075	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FXO12_RS26090	COG0745	RESPONSE REGULATOR receiver
FXO12_RS26095	COG2205	protein histidine kinase activity
FXO12_RS26110	COG0745	RESPONSE REGULATOR receiver
FXO12_RS26120	COG1917	Cupin 2, conserved barrel domain protein
FXO12_RS26120	COG4977	sequence-specific DNA binding
FXO12_RS26125	COG1301	dicarboxylic acid transport
FXO12_RS26130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FXO12_RS26130	COG3608	succinylglutamate desuccinylase aspartoacylase
FXO12_RS26135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXO12_RS26140	COG1530	ribonuclease E activity
FXO12_RS26150	COG0546	phosphoglycolate phosphatase activity
FXO12_RS26155	COG0616	signal peptide processing
FXO12_RS26155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXO12_RS26160	COG0424	maF-like protein
FXO12_RS26165	COG1399	metal-binding, possibly nucleic acid-binding protein
FXO12_RS26170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FXO12_RS26175	COG0416	fatty acid biosynthetic process
FXO12_RS26190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXO12_RS26195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXO12_RS26205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXO12_RS26210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXO12_RS26220	COG0084	hydrolase, TatD family'
FXO12_RS26230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXO12_RS26245	COG2188	Transcriptional regulator
FXO12_RS26250	COG1397	ADP-ribosylglycohydrolase
FXO12_RS26260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXO12_RS26290	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS26295	COG1879	ABC-type sugar transport system periplasmic component
FXO12_RS26300	COG1129	ABC transporter
FXO12_RS26305	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXO12_RS26310	COG1414	Transcriptional regulator
FXO12_RS26315	COG1064	alcohol dehydrogenase
FXO12_RS26320	COG2207	Transcriptional regulator
FXO12_RS26350	COG2885	chlorophyll binding
FXO12_RS26355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXO12_RS26385	COG2308	Evidence 4 Homologs of previously reported genes of
FXO12_RS26395	COG1305	Transglutaminase-like
FXO12_RS26405	COG0183	Belongs to the thiolase family
FXO12_RS26410	COG1024	Enoyl-CoA hydratase
FXO12_RS26410	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXO12_RS26415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FXO12_RS26415	COG0519	Catalyzes the synthesis of GMP from XMP
FXO12_RS26420	COG0598	Magnesium transport protein CorA
FXO12_RS26425	COG0204	Acyl-transferase
FXO12_RS26485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXO12_RS26490	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS26495	COG0583	DNA-binding transcription factor activity
FXO12_RS26505	COG1953	Uracil, thiamine, allantoin
FXO12_RS26515	COG0560	Phosphoserine phosphatase
FXO12_RS26535	COG0189	ligase activity
FXO12_RS26545	COG4067	protein conserved in archaea
FXO12_RS26545	COG0189	ligase activity
FXO12_RS26550	COG1802	Transcriptional regulator
FXO12_RS26560	COG0372	Belongs to the citrate synthase family
FXO12_RS26575	COG2079	MmgE PrpD family protein
FXO12_RS26580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FXO12_RS26585	COG1045	serine acetyltransferase
FXO12_RS26590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXO12_RS26605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXO12_RS26610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FXO12_RS26625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FXO12_RS26650	COG2885	chlorophyll binding
FXO12_RS26650	COG3047	cAMP biosynthetic process
FXO12_RS26655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FXO12_RS26660	COG0243	molybdopterin cofactor binding
FXO12_RS26665	COG2146	nitrite reductase [NAD(P)H] activity
FXO12_RS26670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXO12_RS26680	COG2223	nitrite transmembrane transporter activity
FXO12_RS26685	COG3707	response regulator
FXO12_RS26690	COG1116	anion transmembrane transporter activity
FXO12_RS26690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXO12_RS26705	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FXO12_RS26720	COG0167	dihydroorotate dehydrogenase activity
FXO12_RS26725	COG3130	regulation of translation
FXO12_RS26730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXO12_RS26730	COG0116	Belongs to the methyltransferase superfamily
FXO12_RS26735	COG3706	GGDEF domain
FXO12_RS26745	COG3171	Protein conserved in bacteria
FXO12_RS26750	COG3135	benzoate transporter
FXO12_RS26760	COG0402	S-adenosylhomocysteine deaminase activity
FXO12_RS26770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FXO12_RS26790	COG3115	cell septum assembly
FXO12_RS26795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FXO12_RS26825	COG0583	DNA-binding transcription factor activity
FXO12_RS26835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXO12_RS26840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FXO12_RS26845	COG2130	NADP-dependent
FXO12_RS26850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FXO12_RS26855	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS26860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FXO12_RS26865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXO12_RS26900	COG0348	domain, Protein
FXO12_RS26915	COG2010	Cytochrome c
FXO12_RS26930	COG3278	Belongs to the heme-copper respiratory oxidase family
FXO12_RS26935	COG2010	Cytochrome c
FXO12_RS26950	COG3278	Belongs to the heme-copper respiratory oxidase family
FXO12_RS26970	COG0840	transmembrane signaling receptor activity
FXO12_RS26990	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FXO12_RS26995	COG1643	Atp-dependent helicase
FXO12_RS27005	COG1595	DNA-templated transcription, initiation
FXO12_RS27015	COG2188	Transcriptional regulator
FXO12_RS27025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FXO12_RS27030	COG1132	(ABC) transporter
FXO12_RS27055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXO12_RS27070	COG4221	oxidoreductase activity
FXO12_RS27080	COG0668	transmembrane transport
FXO12_RS27085	COG0513	Belongs to the DEAD box helicase family
FXO12_RS27100	COG2132	Multicopper oxidase
FXO12_RS27135	COG2996	Protein conserved in bacteria
FXO12_RS27150	COG0583	DNA-binding transcription factor activity
FXO12_RS27155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXO12_RS27180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXO12_RS27185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXO12_RS27190	COG3956	TIGRFAM MazG family protein
FXO12_RS27195	COG3122	Protein conserved in bacteria
FXO12_RS27205	COG2814	Major facilitator Superfamily
FXO12_RS27210	COG4264	IucA IucC family
FXO12_RS27225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXO12_RS27230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FXO12_RS27240	COG0628	permease
FXO12_RS27245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXO12_RS27250	COG0791	NLP P60 protein
FXO12_RS27255	COG0791	NLP P60 protein
FXO12_RS27270	COG1797	cobyrinic acid a,c-diamide synthase activity
FXO12_RS27275	COG0778	Nitroreductase
FXO12_RS27280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FXO12_RS27290	COG1492	cobalamin metabolic process
FXO12_RS27300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FXO12_RS27305	COG0406	alpha-ribazole phosphatase activity
FXO12_RS27310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FXO12_RS27315	COG1846	Transcriptional regulator
FXO12_RS27360	COG2205	protein histidine kinase activity
FXO12_RS27365	COG2832	Protein of unknown function (DUF454)
FXO12_RS27375	COG0514	ATP-dependent DNA helicase (RecQ)
FXO12_RS27380	COG1846	Transcriptional regulator
FXO12_RS27385	COG1752	Esterase of the alpha-beta hydrolase superfamily
FXO12_RS27400	COG2207	Transcriptional regulator
FXO12_RS27415	COG2154	pterin-4-alpha-carbinolamine dehydratase
FXO12_RS27425	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FXO12_RS27430	COG4787	bacterial-type flagellum-dependent cell motility
FXO12_RS27435	COG4786	Flagellar basal body rod
FXO12_RS27440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FXO12_RS27445	COG1706	bacterial-type flagellum-dependent cell motility
FXO12_RS27455	COG1256	bacterial-type flagellum assembly
FXO12_RS27465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FXO12_RS27480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FXO12_RS27495	COG2204	response regulator
FXO12_RS27500	COG5002	protein histidine kinase activity
FXO12_RS27505	COG2204	response regulator
FXO12_RS27510	COG1677	Flagellar hook-basal body complex protein FliE
FXO12_RS27545	COG0745	RESPONSE REGULATOR receiver
FXO12_RS27595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FXO12_RS27605	COG1278	Cold shock
FXO12_RS27620	COG0455	bacterial-type flagellum organization
FXO12_RS27635	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FXO12_RS27640	COG0643	Histidine kinase
FXO12_RS27640	COG2198	Histidine kinase
FXO12_RS27645	COG2201	protein-glutamate methylesterase activity
FXO12_RS27650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FXO12_RS27655	COG1360	Flagellar Motor Protein
FXO12_RS27660	COG1192	Involved in chromosome partitioning
FXO12_RS27670	COG0835	chemotaxis
FXO12_RS27680	COG1597	lipid kinase activity
FXO12_RS27685	COG2197	response regulator
FXO12_RS27690	COG3851	Histidine kinase
FXO12_RS27705	COG3217	Mosc domain protein beta barrel domain protein
FXO12_RS27705	COG0633	Ferredoxin
FXO12_RS27710	COG3123	guanosine phosphorylase activity
FXO12_RS27725	COG1024	Enoyl-CoA hydratase
FXO12_RS27730	COG1960	acyl-CoA dehydrogenase activity
FXO12_RS27735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FXO12_RS27750	COG1309	transcriptional regulator
FXO12_RS27780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXO12_RS27790	COG0745	RESPONSE REGULATOR receiver
FXO12_RS27795	COG0642	Histidine kinase
FXO12_RS27815	COG1473	amidohydrolase
FXO12_RS27820	COG0668	transmembrane transport
FXO12_RS27825	COG1362	aminopeptidase activity
FXO12_RS27830	COG0564	pseudouridine synthase activity
FXO12_RS27835	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FXO12_RS27840	COG2894	cell division
FXO12_RS27845	COG0850	regulation of cytokinetic process
FXO12_RS27850	COG1560	Kdo2-lipid A biosynthetic process
FXO12_RS27870	COG2233	PERMEase
FXO12_RS27880	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FXO12_RS27885	COG4266	Belongs to the allantoicase family
FXO12_RS27915	COG2252	PERMEase
FXO12_RS27920	COG0625	glutathione transferase activity
FXO12_RS27925	COG0583	DNA-binding transcription factor activity
FXO12_RS27930	COG2851	Citrate transporter
FXO12_RS27950	COG0302	gtp cyclohydrolase
FXO12_RS27980	COG1073	alpha beta
FXO12_RS27985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXO12_RS27995	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FXO12_RS28000	COG2197	response regulator
FXO12_RS28030	COG1368	sulfuric ester hydrolase activity
FXO12_RS28050	COG3089	Belongs to the UPF0270 family
FXO12_RS28065	COG0367	asparagine synthase
FXO12_RS28070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FXO12_RS28070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXO12_RS28075	COG2326	polyphosphate kinase activity
FXO12_RS28080	COG0183	Belongs to the thiolase family
FXO12_RS28085	COG0697	spore germination
FXO12_RS28090	COG0114	fumarate hydratase activity
FXO12_RS28100	COG0271	Belongs to the BolA IbaG family
FXO12_RS28120	COG5001	Diguanylate cyclase
FXO12_RS28120	COG5002	protein histidine kinase activity
FXO12_RS28130	COG3706	GGDEF domain
FXO12_RS28135	COG1304	FMN binding
FXO12_RS28140	COG0583	DNA-binding transcription factor activity
FXO12_RS28195	COG0745	RESPONSE REGULATOR receiver
FXO12_RS28200	COG0642	Histidine kinase
FXO12_RS28215	COG2391	methyltransferase activity
FXO12_RS28275	COG3657	addiction module killer protein
FXO12_RS28290	COG3469	chitinase activity
FXO12_RS28305	COG2186	Transcriptional regulator
FXO12_RS28310	COG2384	SAM-dependent methyltransferase
FXO12_RS28465	COG1028	Short-chain dehydrogenase reductase Sdr
FXO12_RS28470	COG1902	pentaerythritol trinitrate reductase activity
FXO12_RS28485	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXO12_RS28490	COG3916	Acyl-homoserine-lactone synthase
FXO12_RS28495	COG2197	response regulator
FXO12_RS28510	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FXO12_RS28525	COG1120	ATPase activity
FXO12_RS28530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXO12_RS28535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXO12_RS28540	COG3591	Belongs to the peptidase S1B family
FXO12_RS28540	COG1864	DNA RNA non-specific endonuclease
FXO12_RS28555	COG1012	belongs to the aldehyde dehydrogenase family
FXO12_RS28560	COG0583	DNA-binding transcription factor activity
FXO12_RS28575	COG0556	nucleotide-excision repair
FXO12_RS28580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXO12_RS28620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXO12_RS28645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FXO12_RS28650	COG0066	3-isopropylmalate dehydratase activity
FXO12_RS28655	COG2226	methyltransferase