locus-tag	class	description
C4J83_RS00010	COG0592	DNA-directed DNA polymerase activity
C4J83_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J83_RS00020	COG0187	DNA topoisomerase II activity
C4J83_RS00025	COG0745	RESPONSE REGULATOR receiver
C4J83_RS00030	COG5002	protein histidine kinase activity
C4J83_RS00040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4J83_RS00045	COG0751	glycine-tRNA ligase activity
C4J83_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
C4J83_RS00055	COG2818	Glycosylase
C4J83_RS00070	COG0569	domain protein
C4J83_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4J83_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J83_RS00085	COG0242	peptide deformylase activity
C4J83_RS00095	COG0758	DNA mediated transformation
C4J83_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
C4J83_RS00110	COG0408	coproporphyrinogen oxidase activity
C4J83_RS00115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J83_RS00135	COG3119	arylsulfatase activity
C4J83_RS00140	COG0583	DNA-binding transcription factor activity
C4J83_RS00150	COG3734	2-keto-3-deoxy-galactonokinase
C4J83_RS00155	COG0800	Aldolase
C4J83_RS00160	COG4948	Mandelate Racemase Muconate Lactonizing
C4J83_RS00165	COG2271	Major facilitator Superfamily
C4J83_RS00175	COG0159	tryptophan synthase activity
C4J83_RS00195	COG3360	Dodecin
C4J83_RS00205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS00210	COG1764	response to oxidative stress
C4J83_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4J83_RS00240	COG0339	signal peptide processing
C4J83_RS00280	COG0659	secondary active sulfate transmembrane transporter activity
C4J83_RS00290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J83_RS00295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J83_RS00305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4J83_RS00335	COG0109	protoheme IX farnesyltransferase activity
C4J83_RS00355	COG2011	ABC-type metal ion transport system permease component
C4J83_RS00360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J83_RS00375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J83_RS00380	COG1121	(ABC) transporter
C4J83_RS00385	COG0735	belongs to the Fur family
C4J83_RS00390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4J83_RS00410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4J83_RS00425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4J83_RS00440	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J83_RS00445	COG5002	protein histidine kinase activity
C4J83_RS00450	COG2204	response regulator
C4J83_RS00460	COG5487	UPF0391 membrane protein
C4J83_RS00470	COG1301	dicarboxylic acid transport
C4J83_RS00475	COG0700	Nucleoside recognition
C4J83_RS00490	COG1127	ABC transporter
C4J83_RS00495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J83_RS00505	COG0612	Peptidase, M16
C4J83_RS00510	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4J83_RS00515	COG0861	Integral membrane protein TerC family
C4J83_RS00520	COG2851	Citrate transporter
C4J83_RS00555	COG0427	acetyl-CoA hydrolase
C4J83_RS00575	COG0583	DNA-binding transcription factor activity
C4J83_RS00580	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS00630	COG3712	iron ion homeostasis
C4J83_RS00635	COG1595	DNA-templated transcription, initiation
C4J83_RS00640	COG0840	transmembrane signaling receptor activity
C4J83_RS00675	COG5001	Diguanylate cyclase
C4J83_RS00675	COG3300	MHYT domain
C4J83_RS00690	COG1538	Outer membrane efflux protein
C4J83_RS00695	COG2274	protein secretion by the type I secretion system
C4J83_RS00700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS00705	COG2175	clavaminate synthase activity
C4J83_RS00715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J83_RS00770	COG1289	transmembrane transporter activity
C4J83_RS00780	COG1566	PFAM secretion protein HlyD family protein
C4J83_RS00795	COG5339	Protein conserved in bacteria
C4J83_RS00800	COG0457	Tetratricopeptide repeat
C4J83_RS00805	COG1649	PFAM Uncharacterised BCR, COG1649
C4J83_RS00805	COG0726	polysaccharide deacetylase
C4J83_RS00810	COG1215	transferase activity, transferring glycosyl groups
C4J83_RS00930	COG2304	oxidoreductase activity
C4J83_RS00935	COG1595	DNA-templated transcription, initiation
C4J83_RS00950	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS00955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J83_RS00960	COG0745	RESPONSE REGULATOR receiver
C4J83_RS00965	COG2199	diguanylate cyclase activity
C4J83_RS00985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J83_RS00995	COG4208	sulfate ABC transporter
C4J83_RS01000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4J83_RS01010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J83_RS01040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J83_RS01045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS01070	COG4771	TonB-dependent receptor
C4J83_RS01075	COG2807	transmembrane transport
C4J83_RS01080	COG0583	DNA-binding transcription factor activity
C4J83_RS01115	COG0765	amino acid transport
C4J83_RS01120	COG0765	amino acid transport
C4J83_RS01125	COG1126	abc transporter atp-binding protein
C4J83_RS01130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS01155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J83_RS01170	COG2011	ABC-type metal ion transport system permease component
C4J83_RS01175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J83_RS01180	COG1464	Belongs to the NlpA lipoprotein family
C4J83_RS01205	COG1126	abc transporter atp-binding protein
C4J83_RS01210	COG0765	amino acid transport
C4J83_RS01215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS01220	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4J83_RS01225	COG1045	serine acetyltransferase
C4J83_RS01230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J83_RS01240	COG0667	Aldo Keto reductase
C4J83_RS01270	COG2175	clavaminate synthase activity
C4J83_RS01275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J83_RS01280	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4J83_RS01285	COG4521	taurine ABC transporter
C4J83_RS01290	COG2918	glutathione biosynthetic process
C4J83_RS01300	COG2183	response to ionizing radiation
C4J83_RS01315	COG0189	ligase activity
C4J83_RS01320	COG4067	protein conserved in archaea
C4J83_RS01320	COG0189	ligase activity
C4J83_RS01325	COG2200	EAL domain
C4J83_RS01330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4J83_RS01340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4J83_RS01345	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4J83_RS01380	COG0514	ATP-dependent DNA helicase (RecQ)
C4J83_RS01385	COG0824	Thioesterase
C4J83_RS01395	COG0243	molybdopterin cofactor binding
C4J83_RS01410	COG1652	LysM domain
C4J83_RS01415	COG1011	Hydrolase
C4J83_RS01420	COG0494	nUDIX hydrolase
C4J83_RS01425	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4J83_RS01450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J83_RS01455	COG2957	Belongs to the agmatine deiminase family
C4J83_RS01480	COG1942	4-Oxalocrotonate Tautomerase
C4J83_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS01510	COG1192	Involved in chromosome partitioning
C4J83_RS01530	COG4215	(ABC) transporter
C4J83_RS01575	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4J83_RS01580	COG1194	a g-specific adenine glycosylase
C4J83_RS01590	COG2223	nitrite transmembrane transporter activity
C4J83_RS01605	COG0131	Imidazoleglycerol-phosphate dehydratase
C4J83_RS01610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4J83_RS01620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4J83_RS01625	COG0107	imidazoleglycerol-phosphate synthase activity
C4J83_RS01635	COG2861	carbohydrate metabolic process
C4J83_RS01640	COG0793	Belongs to the peptidase S41A family
C4J83_RS01645	COG4942	peptidase
C4J83_RS01650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4J83_RS01655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J83_RS01665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4J83_RS01690	COG3852	Histidine kinase
C4J83_RS01720	COG0301	tRNA thio-modification
C4J83_RS01720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J83_RS01725	COG1217	gtp-binding protein TYPA
C4J83_RS01735	COG0058	SHG alpha-glucan phosphorylase activity
C4J83_RS01750	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4J83_RS01765	COG0402	S-adenosylhomocysteine deaminase activity
C4J83_RS01770	COG2188	Transcriptional regulator
C4J83_RS01780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4J83_RS01785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J83_RS01795	COG4176	ABC-type proline glycine betaine transport system permease component
C4J83_RS01800	COG0517	IMP dehydrogenase activity
C4J83_RS01800	COG4175	Glycine betaine
C4J83_RS01805	COG2986	histidine ammonia-lyase
C4J83_RS01810	COG2986	histidine ammonia-lyase
C4J83_RS01820	COG1228	amidohydrolase
C4J83_RS01840	COG0596	Alpha beta hydrolase
C4J83_RS01845	COG1490	D-aminoacyl-tRNA deacylase activity
C4J83_RS01850	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J83_RS01855	COG2943	transferase activity, transferring hexosyl groups
C4J83_RS01865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS01870	COG0765	amino acid transport
C4J83_RS01875	COG1126	abc transporter atp-binding protein
C4J83_RS01880	COG0840	transmembrane signaling receptor activity
C4J83_RS01895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J83_RS01900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J83_RS01905	COG0140	phosphoribosyl-ATP diphosphatase activity
C4J83_RS01910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J83_RS01915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J83_RS01925	COG2226	methyltransferase
C4J83_RS01975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4J83_RS01980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4J83_RS01990	COG0018	arginyl-trna synthetase
C4J83_RS01995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4J83_RS02000	COG0254	rRNA binding
C4J83_RS02005	COG0281	malic enzyme
C4J83_RS02035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4J83_RS02040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J83_RS02055	COG0070	glutamate synthase
C4J83_RS02055	COG0069	glutamate synthase activity
C4J83_RS02055	COG0067	glutamate synthase
C4J83_RS02060	COG0493	'glutamate synthase
C4J83_RS02065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4J83_RS02070	COG2814	Major facilitator Superfamily
C4J83_RS02075	COG0583	DNA-binding transcription factor activity
C4J83_RS02090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J83_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS02105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J83_RS02115	COG2226	methyltransferase
C4J83_RS02140	COG2986	histidine ammonia-lyase
C4J83_RS02155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J83_RS02165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J83_RS02170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J83_RS02185	COG1192	Involved in chromosome partitioning
C4J83_RS02195	COG3118	belongs to the thioredoxin family
C4J83_RS02200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4J83_RS02205	COG3264	Mechanosensitive ion channel
C4J83_RS02205	COG1196	nuclear chromosome segregation
C4J83_RS02210	COG3263	regulation of cellular component size
C4J83_RS02230	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS02235	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J83_RS02235	COG0506	proline dehydrogenase activity
C4J83_RS02235	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J83_RS02240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J83_RS02265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4J83_RS02275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J83_RS02295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J83_RS02305	COG0859	PFAM glycosyl transferase family 9
C4J83_RS02310	COG0859	PFAM glycosyl transferase family 9
C4J83_RS02315	COG0438	transferase activity, transferring glycosyl groups
C4J83_RS02325	COG3642	lipopolysaccharide core region biosynthetic process
C4J83_RS02340	COG4772	TonB-dependent receptor
C4J83_RS02355	COG2192	nodulation
C4J83_RS02360	COG0438	transferase activity, transferring glycosyl groups
C4J83_RS02385	COG1215	transferase activity, transferring glycosyl groups
C4J83_RS02395	COG1132	(ABC) transporter
C4J83_RS02400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4J83_RS02400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4J83_RS02405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J83_RS02415	COG0667	Aldo Keto reductase
C4J83_RS02435	COG1519	Transferase
C4J83_RS02440	COG1538	Outer membrane efflux protein
C4J83_RS02445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4J83_RS02460	COG0494	nUDIX hydrolase
C4J83_RS02470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J83_RS02475	COG3150	esterase
C4J83_RS02510	COG3830	Belongs to the UPF0237 family
C4J83_RS02510	COG0560	Phosphoserine phosphatase
C4J83_RS02515	COG0688	phosphatidylethanolamine metabolic process
C4J83_RS02540	COG1162	GTPase activity
C4J83_RS02545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4J83_RS02550	COG2860	membrane
C4J83_RS02560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4J83_RS02560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4J83_RS02565	COG0802	atpase or kinase
C4J83_RS02570	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J83_RS02575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4J83_RS02580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4J83_RS02585	COG1923	regulation of RNA biosynthetic process
C4J83_RS02590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4J83_RS02595	COG0330	HflC and HflK could
C4J83_RS02600	COG0330	HflC and HflK could
C4J83_RS02605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4J83_RS02610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4J83_RS02620	COG1178	ABC-type Fe3 transport system permease component
C4J83_RS02625	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J83_RS02640	COG0557	exoribonuclease II activity
C4J83_RS02645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J83_RS02650	COG0360	Binds together with S18 to 16S ribosomal RNA
C4J83_RS02655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J83_RS02665	COG0359	binds to the 23S rRNA
C4J83_RS02670	COG0305	Participates in initiation and elongation during chromosome replication
C4J83_RS02675	COG1032	radical SAM domain protein
C4J83_RS02695	COG2307	Protein conserved in bacteria
C4J83_RS02695	COG2308	Evidence 4 Homologs of previously reported genes of
C4J83_RS02715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J83_RS02720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4J83_RS02725	COG0583	DNA-binding transcription factor activity
C4J83_RS02730	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS02735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS02770	COG4221	oxidoreductase activity
C4J83_RS02790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4J83_RS02795	COG0830	nickel cation binding
C4J83_RS02800	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4J83_RS02805	COG0791	NLP P60 protein
C4J83_RS02810	COG1309	transcriptional regulator
C4J83_RS02820	COG2982	Protein involved in outer membrane biogenesis
C4J83_RS02830	COG0583	DNA-binding transcription factor activity
C4J83_RS02835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J83_RS02840	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4J83_RS02845	COG0697	spore germination
C4J83_RS02875	COG0443	Heat shock 70 kDa protein
C4J83_RS02880	COG0484	heat shock protein binding
C4J83_RS02890	COG0804	urea catabolic process
C4J83_RS02895	COG0832	Belongs to the urease beta subunit family
C4J83_RS02910	COG0831	urea catabolic process
C4J83_RS02915	COG0829	nickel cation binding
C4J83_RS02925	COG0411	ABC transporter
C4J83_RS02950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J83_RS02960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J83_RS02965	COG4774	siderophore transport
C4J83_RS03005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J83_RS03030	COG2095	MarC family integral membrane protein
C4J83_RS03040	COG0151	Belongs to the GarS family
C4J83_RS03045	COG0138	bifunctional purine biosynthesis protein purh
C4J83_RS03055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J83_RS03070	COG2264	protein methyltransferase activity
C4J83_RS03085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J83_RS03110	COG0023	Translation Initiation Factor
C4J83_RS03115	COG1166	arginine decarboxylase activity
C4J83_RS03125	COG0534	Mate efflux family protein
C4J83_RS03130	COG2373	Large extracellular alpha-helical protein
C4J83_RS03140	COG4953	penicillin-binding protein 1C
C4J83_RS03150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J83_RS03220	COG4964	Belongs to the GSP D family
C4J83_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS03285	COG2217	Heavy metal translocating P-type atpase
C4J83_RS03300	COG2814	Major facilitator Superfamily
C4J83_RS03310	COG0604	alcohol dehydrogenase
C4J83_RS03315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4J83_RS03320	COG0583	DNA-binding transcription factor activity
C4J83_RS03330	COG0477	Major facilitator Superfamily
C4J83_RS03335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J83_RS03340	COG0387	Pfam Sodium calcium exchanger
C4J83_RS03375	COG1309	transcriptional regulator
C4J83_RS03380	COG2233	PERMEase
C4J83_RS03430	COG2995	paraquat-inducible protein a
C4J83_RS03435	COG2995	paraquat-inducible protein a
C4J83_RS03440	COG3008	intermembrane lipid transfer
C4J83_RS03465	COG0456	acetyltransferase
C4J83_RS03475	COG0288	reversible hydration of carbon dioxide
C4J83_RS03495	COG2031	fatty acid transporter
C4J83_RS03555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4J83_RS03580	COG3655	Transcriptional regulator
C4J83_RS03595	COG1496	oxidoreductase activity
C4J83_RS03600	COG0405	Gamma-glutamyltransferase
C4J83_RS03690	COG0582	viral genome integration into host DNA
C4J83_RS03725	COG1157	protein secretion by the type III secretion system
C4J83_RS03750	COG4794	Type iii secretion
C4J83_RS03760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J83_RS03790	COG4669	(LipO)protein
C4J83_RS03810	COG0193	aminoacyl-tRNA hydrolase activity
C4J83_RS03815	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4J83_RS03820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J83_RS03830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4J83_RS03835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4J83_RS03845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4J83_RS03850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4J83_RS03865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4J83_RS03885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J83_RS03895	COG0493	'glutamate synthase
C4J83_RS03900	COG4221	oxidoreductase activity
C4J83_RS03910	COG0415	Belongs to the DNA photolyase family
C4J83_RS03915	COG0789	Transcriptional regulator
C4J83_RS03930	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4J83_RS03935	COG1090	epimerase
C4J83_RS03940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4J83_RS03955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J83_RS03965	COG0175	sulfate reduction
C4J83_RS03975	COG0204	Acyl-transferase
C4J83_RS03980	COG0280	phosphate acetyltransferase
C4J83_RS03980	COG0857	belongs to the CobB CobQ family
C4J83_RS03995	COG0268	Binds directly to 16S ribosomal RNA
C4J83_RS04005	COG0196	riboflavin kinase activity
C4J83_RS04010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4J83_RS04015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J83_RS04020	COG1047	Peptidyl-prolyl cis-trans
C4J83_RS04025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4J83_RS04055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS04080	COG0542	response to heat
C4J83_RS04105	COG1335	isochorismatase
C4J83_RS04110	COG0583	DNA-binding transcription factor activity
C4J83_RS04115	COG1252	NADH dehydrogenase
C4J83_RS04145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4J83_RS04150	COG0237	dephospho-CoA kinase activity
C4J83_RS04190	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J83_RS04200	COG0840	transmembrane signaling receptor activity
C4J83_RS04210	COG0084	hydrolase, TatD family'
C4J83_RS04215	COG1609	Transcriptional regulator
C4J83_RS04225	COG1105	Belongs to the carbohydrate kinase PfkB family
C4J83_RS04230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J83_RS04230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J83_RS04230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4J83_RS04240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4J83_RS04245	COG4774	siderophore transport
C4J83_RS04250	COG3128	pkhd-type hydroxylase
C4J83_RS04260	COG0019	diaminopimelate decarboxylase activity
C4J83_RS04285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4J83_RS04310	COG4608	Belongs to the ABC transporter superfamily
C4J83_RS04315	COG0444	Belongs to the ABC transporter superfamily
C4J83_RS04320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J83_RS04325	COG0601	transmembrane transport
C4J83_RS04330	COG0747	negative chemotaxis
C4J83_RS04340	COG0747	negative chemotaxis
C4J83_RS04345	COG0747	negative chemotaxis
C4J83_RS04350	COG0747	negative chemotaxis
C4J83_RS04365	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4J83_RS04370	COG4178	(ABC) transporter
C4J83_RS04385	COG0180	Tryptophanyl-tRNA synthetase
C4J83_RS04390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J83_RS04400	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS04405	COG0667	Aldo Keto reductase
C4J83_RS04410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4J83_RS04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4J83_RS04420	COG0723	plastoquinol--plastocyanin reductase activity
C4J83_RS04425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J83_RS04430	COG2857	Cytochrome c1
C4J83_RS04435	COG0625	glutathione transferase activity
C4J83_RS04440	COG2969	positive regulation of protein catabolic process
C4J83_RS04445	COG2186	Transcriptional regulator
C4J83_RS04455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J83_RS04465	COG2271	Major facilitator Superfamily
C4J83_RS04470	COG2721	sulfolactate sulfo-lyase activity
C4J83_RS04480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS04490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J83_RS04495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J83_RS04500	COG0154	amidase activity
C4J83_RS04505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J83_RS04510	COG1077	Cell shape determining protein MreB Mrl
C4J83_RS04515	COG1792	Involved in formation and maintenance of cell shape
C4J83_RS04525	COG0424	maF-like protein
C4J83_RS04530	COG1530	ribonuclease E activity
C4J83_RS04540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J83_RS04545	COG0312	modulator of DNA gyrase
C4J83_RS04550	COG3028	Belongs to the UPF0307 family
C4J83_RS04555	COG0312	modulator of DNA gyrase
C4J83_RS04590	COG1660	Displays ATPase and GTPase activities
C4J83_RS04605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4J83_RS04610	COG1137	ATPase activity
C4J83_RS04615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4J83_RS04625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4J83_RS04635	COG1127	ABC transporter
C4J83_RS04640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J83_RS04645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4J83_RS04665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J83_RS04670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4J83_RS04675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4J83_RS04680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J83_RS04690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4J83_RS04695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4J83_RS04755	COG2135	peptidase activity
C4J83_RS04760	COG0840	transmembrane signaling receptor activity
C4J83_RS04765	COG0501	Belongs to the peptidase M48B family
C4J83_RS04770	COG2119	membrane
C4J83_RS04775	COG2813	Specifically methylates the guanine in position
C4J83_RS04780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J83_RS04785	COG1280	lysine exporter protein (LysE YggA)
C4J83_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
C4J83_RS04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J83_RS04820	COG2885	chlorophyll binding
C4J83_RS04825	COG2823	Periplasmic or secreted lipoprotein
C4J83_RS04830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4J83_RS04835	COG0792	nuclease activity
C4J83_RS04855	COG2001	Belongs to the MraZ family
C4J83_RS04860	COG0275	rRNA processing
C4J83_RS04875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J83_RS04880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4J83_RS04885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J83_RS04890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J83_RS04895	COG0772	Belongs to the SEDS family
C4J83_RS04900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J83_RS04905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J83_RS04910	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J83_RS04925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4J83_RS04930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4J83_RS04940	COG2203	Gaf domain
C4J83_RS04940	COG3706	GGDEF domain
C4J83_RS04940	COG5001	Diguanylate cyclase
C4J83_RS04940	COG4251	negative regulation of phosphorylation
C4J83_RS04945	COG5001	Diguanylate cyclase
C4J83_RS04945	COG3706	GGDEF domain
C4J83_RS04945	COG4251	negative regulation of phosphorylation
C4J83_RS04945	COG2203	Gaf domain
C4J83_RS04960	COG5002	protein histidine kinase activity
C4J83_RS04985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS04990	COG0840	transmembrane signaling receptor activity
C4J83_RS04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS05010	COG0784	Response regulator, receiver
C4J83_RS05010	COG0835	chemotaxis
C4J83_RS05015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J83_RS05025	COG0583	DNA-binding transcription factor activity
C4J83_RS05045	COG1566	PFAM secretion protein HlyD family protein
C4J83_RS05060	COG0477	Major facilitator Superfamily
C4J83_RS05070	COG0300	oxidoreductase activity
C4J83_RS05085	COG0662	Cupin 2, conserved barrel domain protein
C4J83_RS05085	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J83_RS05100	COG1696	Membrane protein involved in D-alanine export
C4J83_RS05115	COG3420	alginic acid biosynthetic process
C4J83_RS05125	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4J83_RS05130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS05140	COG1215	transferase activity, transferring glycosyl groups
C4J83_RS05150	COG3022	response to hydroperoxide
C4J83_RS05160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4J83_RS05170	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J83_RS05175	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4J83_RS05185	COG0513	Belongs to the DEAD box helicase family
C4J83_RS05190	COG0400	carboxylic ester hydrolase activity
C4J83_RS05195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS05200	COG4597	amino acid ABC transporter
C4J83_RS05205	COG0765	amino acid transport
C4J83_RS05210	COG1126	abc transporter atp-binding protein
C4J83_RS05215	COG2944	sequence-specific DNA binding
C4J83_RS05225	COG2186	Transcriptional regulator
C4J83_RS05230	COG2807	transmembrane transport
C4J83_RS05235	COG3539	Fimbrial protein
C4J83_RS05245	COG3539	Fimbrial protein
C4J83_RS05250	COG3188	usher protein
C4J83_RS05255	COG3121	Chaperone
C4J83_RS05280	COG2198	Histidine kinase
C4J83_RS05280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS05280	COG2205	protein histidine kinase activity
C4J83_RS05280	COG0784	Response regulator, receiver
C4J83_RS05295	COG2827	Endonuclease containing a URI domain
C4J83_RS05305	COG4774	siderophore transport
C4J83_RS05310	COG2027	D-alanyl-D-alanine carboxypeptidase
C4J83_RS05320	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4J83_RS05325	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J83_RS05345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4J83_RS05365	COG0814	amino acid
C4J83_RS05370	COG1760	l-serine dehydratase
C4J83_RS05375	COG0583	DNA-binding transcription factor activity
C4J83_RS05390	COG0583	DNA-binding transcription factor activity
C4J83_RS05395	COG4772	TonB-dependent receptor
C4J83_RS05400	COG3712	iron ion homeostasis
C4J83_RS05405	COG1595	DNA-templated transcription, initiation
C4J83_RS05445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4J83_RS05450	COG3081	Nucleoid-associated protein
C4J83_RS05460	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4J83_RS05465	COG0525	valine-tRNA ligase activity
C4J83_RS05480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4J83_RS05485	COG0795	lipopolysaccharide-transporting ATPase activity
C4J83_RS05490	COG0795	lipopolysaccharide-transporting ATPase activity
C4J83_RS05495	COG0481	GTPase activity
C4J83_RS05500	COG0681	Belongs to the peptidase S26 family
C4J83_RS05505	COG0571	ribonuclease III activity
C4J83_RS05510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4J83_RS05515	COG1381	Involved in DNA repair and RecF pathway recombination
C4J83_RS05520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4J83_RS05530	COG0590	tRNA wobble adenosine to inosine editing
C4J83_RS05535	COG0500	methyltransferase
C4J83_RS05540	COG2226	methyltransferase
C4J83_RS05555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J83_RS05595	COG0523	cobalamin synthesis protein
C4J83_RS05615	COG4206	TonB-dependent receptor
C4J83_RS05620	COG4628	conserved protein (DUF2132)
C4J83_RS05630	COG2375	cellular response to nickel ion
C4J83_RS05635	COG1695	Transcriptional regulator
C4J83_RS05680	COG1113	amino acid transport
C4J83_RS05695	COG0069	glutamate synthase activity
C4J83_RS05700	COG2197	response regulator
C4J83_RS05710	COG0531	amino acid
C4J83_RS05715	COG0254	rRNA binding
C4J83_RS05740	COG0583	DNA-binding transcription factor activity
C4J83_RS05765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J83_RS05780	COG4191	Histidine kinase
C4J83_RS05810	COG1126	abc transporter atp-binding protein
C4J83_RS05815	COG0765	amino acid transport
C4J83_RS05820	COG0765	amino acid transport
C4J83_RS05825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS05835	COG4774	siderophore transport
C4J83_RS05855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J83_RS05865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4J83_RS05870	COG3842	ATPase activity
C4J83_RS05875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4J83_RS05885	COG0243	molybdopterin cofactor binding
C4J83_RS05890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4J83_RS05905	COG0450	alkyl hydroperoxide reductase
C4J83_RS05910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J83_RS05915	COG0418	dihydroorotase activity
C4J83_RS05925	COG0137	argininosuccinate synthase activity
C4J83_RS05930	COG2197	response regulator
C4J83_RS05940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4J83_RS05945	COG2878	Part of a membrane complex involved in electron transport
C4J83_RS05950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J83_RS05950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J83_RS05955	COG0489	protein tyrosine kinase activity
C4J83_RS05960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4J83_RS05965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4J83_RS06185	COG1546	Belongs to the CinA family
C4J83_RS06190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4J83_RS06195	COG2137	regulation of response to DNA damage stimulus
C4J83_RS06210	COG3148	PFAM DTW domain containing protein
C4J83_RS06225	COG0583	DNA-binding transcription factor activity
C4J83_RS06240	COG4807	Protein conserved in bacteria
C4J83_RS06255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J83_RS06260	COG3158	transport of potassium into the cell
C4J83_RS06265	COG1902	pentaerythritol trinitrate reductase activity
C4J83_RS06275	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J83_RS06280	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C4J83_RS06285	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS06290	COG1177	transmembrane transport
C4J83_RS06295	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J83_RS06300	COG3842	ATPase activity
C4J83_RS06305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4J83_RS06315	COG0583	DNA-binding transcription factor activity
C4J83_RS06335	COG0457	Tetratricopeptide repeat
C4J83_RS06335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J83_RS06350	COG2201	protein-glutamate methylesterase activity
C4J83_RS06355	COG5001	Diguanylate cyclase
C4J83_RS06355	COG2203	Gaf domain
C4J83_RS06355	COG3706	GGDEF domain
C4J83_RS06355	COG4251	negative regulation of phosphorylation
C4J83_RS06365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4J83_RS06385	COG1073	alpha beta
C4J83_RS06400	COG2885	chlorophyll binding
C4J83_RS06415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4J83_RS06420	COG0563	adenylate kinase activity
C4J83_RS06425	COG1214	PFAM Peptidase M22, glycoprotease
C4J83_RS06435	COG1801	Protein of unknown function DUF72
C4J83_RS06455	COG0742	ribosomal rna small subunit methyltransferase
C4J83_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS06490	COG2937	Belongs to the GPAT DAPAT family
C4J83_RS06505	COG2226	methyltransferase
C4J83_RS06510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J83_RS06515	COG1215	transferase activity, transferring glycosyl groups
C4J83_RS06520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4J83_RS06525	COG2166	iron-sulfur cluster assembly
C4J83_RS06530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J83_RS06535	COG2171	N-acyltransferase activity
C4J83_RS06540	COG1393	Belongs to the ArsC family
C4J83_RS06545	COG0025	NhaP-type Na H and K H
C4J83_RS06550	COG0436	Aminotransferase
C4J83_RS06555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4J83_RS06560	COG0024	Methionine aminopeptidase
C4J83_RS06565	COG0052	Belongs to the universal ribosomal protein uS2 family
C4J83_RS06570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4J83_RS06575	COG0528	UMP kinase activity
C4J83_RS06580	COG0233	cytoplasmic translational termination
C4J83_RS06585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J83_RS06595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4J83_RS06605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J83_RS06615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J83_RS06620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J83_RS06625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J83_RS06630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J83_RS06635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4J83_RS06640	COG0587	DNA-directed DNA polymerase activity
C4J83_RS06645	COG0825	malonyl-CoA metabolic process
C4J83_RS06650	COG0037	tRNA processing
C4J83_RS06655	COG0504	CTP synthase activity
C4J83_RS06660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4J83_RS06665	COG0148	phosphopyruvate hydratase activity
C4J83_RS06675	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4J83_RS06685	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4J83_RS06690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4J83_RS06695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4J83_RS06700	COG0585	pseudouridine synthase activity
C4J83_RS06705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4J83_RS06710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4J83_RS06730	COG1278	Cold shock
C4J83_RS06735	COG0717	Belongs to the dCTP deaminase family
C4J83_RS06750	COG1201	RNA secondary structure unwinding
C4J83_RS06765	COG4160	amino acid transport
C4J83_RS06780	COG1793	dna ligase
C4J83_RS06790	COG2366	antibiotic biosynthetic process
C4J83_RS06795	COG0625	glutathione transferase activity
C4J83_RS06800	COG1120	ATPase activity
C4J83_RS06805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J83_RS06815	COG4774	siderophore transport
C4J83_RS06835	COG0653	protein targeting
C4J83_RS06845	COG3012	SEC-C Motif Domain Protein
C4J83_RS06875	COG1199	ATP-dependent helicase activity
C4J83_RS06895	COG0259	pyridoxamine-phosphate oxidase activity
C4J83_RS06910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J83_RS06920	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4J83_RS06935	COG0583	DNA-binding transcription factor activity
C4J83_RS06950	COG3220	belongs to the UPF0276 family
C4J83_RS07005	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4J83_RS07015	COG2271	Major facilitator Superfamily
C4J83_RS07020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J83_RS07040	COG0583	DNA-binding transcription factor activity
C4J83_RS07050	COG0306	phosphate transporter
C4J83_RS07070	COG1414	Transcriptional regulator
C4J83_RS07075	COG2814	Major facilitator Superfamily
C4J83_RS07080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J83_RS07085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4J83_RS07090	COG0183	Belongs to the thiolase family
C4J83_RS07095	COG3485	protocatechuate 3,4-dioxygenase
C4J83_RS07100	COG3485	protocatechuate 3,4-dioxygenase
C4J83_RS07105	COG0477	Major facilitator Superfamily
C4J83_RS07115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J83_RS07120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS07145	COG0443	Heat shock 70 kDa protein
C4J83_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS07165	COG1309	transcriptional regulator
C4J83_RS07175	COG1902	pentaerythritol trinitrate reductase activity
C4J83_RS07180	COG2814	Major facilitator Superfamily
C4J83_RS07220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J83_RS07235	COG1704	LemA family
C4J83_RS07260	COG0697	spore germination
C4J83_RS07265	COG1629	transport
C4J83_RS07275	COG1595	DNA-templated transcription, initiation
C4J83_RS07285	COG1454	alcohol dehydrogenase
C4J83_RS07300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J83_RS07305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J83_RS07310	COG2271	Major facilitator Superfamily
C4J83_RS07345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J83_RS07350	COG0583	DNA-binding transcription factor activity
C4J83_RS07355	COG2814	Major facilitator Superfamily
C4J83_RS07380	COG2267	carboxylic ester hydrolase activity
C4J83_RS07410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J83_RS07445	COG0642	Histidine kinase
C4J83_RS07460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4J83_RS07490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J83_RS07500	COG0425	Belongs to the sulfur carrier protein TusA family
C4J83_RS07505	COG0628	permease
C4J83_RS07510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4J83_RS07520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J83_RS07525	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4J83_RS07530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J83_RS07535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4J83_RS07595	COG4191	Histidine kinase
C4J83_RS07595	COG0784	Response regulator, receiver
C4J83_RS07600	COG2205	protein histidine kinase activity
C4J83_RS07610	COG2172	sigma factor antagonist activity
C4J83_RS07615	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J83_RS07620	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J83_RS07625	COG0583	DNA-binding transcription factor activity
C4J83_RS07670	COG2807	transmembrane transport
C4J83_RS07675	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS07685	COG0583	DNA-binding transcription factor activity
C4J83_RS07690	COG2910	NAD(P)H-binding
C4J83_RS07700	COG0583	DNA-binding transcription factor activity
C4J83_RS07730	COG0174	glutamine synthetase
C4J83_RS07745	COG3100	YcgL domain-containing protein
C4J83_RS07750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J83_RS07760	COG2983	Belongs to the UPF0260 family
C4J83_RS07805	COG1770	oligopeptidase
C4J83_RS07815	COG0121	glutamine amidotransferase
C4J83_RS07825	COG0583	DNA-binding transcription factor activity
C4J83_RS07830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4J83_RS07835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4J83_RS07840	COG1984	allophanate hydrolase subunit 2
C4J83_RS07850	COG0542	response to heat
C4J83_RS07865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J83_RS07880	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4J83_RS07885	COG0425	Belongs to the sulfur carrier protein TusA family
C4J83_RS07900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J83_RS07905	COG1132	(ABC) transporter
C4J83_RS07910	COG0741	lytic transglycosylase activity
C4J83_RS07915	COG0488	(ABC) transporter
C4J83_RS07920	COG0589	response to stress
C4J83_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J83_RS07930	COG1024	Enoyl-CoA hydratase
C4J83_RS07935	COG0183	Belongs to the thiolase family
C4J83_RS07980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J83_RS07990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4J83_RS08010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J83_RS08015	COG0584	glycerophosphoryl diester phosphodiesterase
C4J83_RS08025	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J83_RS08030	COG1136	(ABC) transporter
C4J83_RS08035	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J83_RS08055	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J83_RS08055	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J83_RS08070	COG2853	Lipoprotein
C4J83_RS08085	COG2204	response regulator
C4J83_RS08095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J83_RS08100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J83_RS08315	COG4695	Portal protein
C4J83_RS08325	COG2135	peptidase activity
C4J83_RS08365	COG2814	Major facilitator Superfamily
C4J83_RS08370	COG0579	oxidoreductase
C4J83_RS08380	COG0583	DNA-binding transcription factor activity
C4J83_RS08385	COG0583	DNA-binding transcription factor activity
C4J83_RS08420	COG1611	Belongs to the LOG family
C4J83_RS08430	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4J83_RS08440	COG0583	DNA-binding transcription factor activity
C4J83_RS08445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J83_RS08455	COG0583	DNA-binding transcription factor activity
C4J83_RS08460	COG2814	Major facilitator Superfamily
C4J83_RS08470	COG2233	PERMEase
C4J83_RS08475	COG2267	carboxylic ester hydrolase activity
C4J83_RS08480	COG2197	response regulator
C4J83_RS08485	COG0596	Alpha beta hydrolase
C4J83_RS08495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J83_RS08500	COG0444	Belongs to the ABC transporter superfamily
C4J83_RS08505	COG4608	Belongs to the ABC transporter superfamily
C4J83_RS08510	COG0747	negative chemotaxis
C4J83_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS08520	COG0546	phosphoglycolate phosphatase activity
C4J83_RS08525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J83_RS08530	COG0402	S-adenosylhomocysteine deaminase activity
C4J83_RS08535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4J83_RS08545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4J83_RS08555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J83_RS08560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J83_RS08565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4J83_RS08580	COG0776	regulation of translation
C4J83_RS08595	COG2244	polysaccharide biosynthetic process
C4J83_RS08620	COG0438	transferase activity, transferring glycosyl groups
C4J83_RS08640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4J83_RS08650	COG1555	photosystem II stabilization
C4J83_RS08685	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J83_RS08695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J83_RS08700	COG2205	protein histidine kinase activity
C4J83_RS08705	COG0745	RESPONSE REGULATOR receiver
C4J83_RS08740	COG3209	COG3209 Rhs family protein
C4J83_RS08755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J83_RS08760	COG2259	Doxx family
C4J83_RS08780	COG1131	(ABC) transporter
C4J83_RS08790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J83_RS08795	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4J83_RS08800	COG4181	ATPase activity
C4J83_RS08815	COG1376	ErfK ybiS ycfS ynhG family protein
C4J83_RS08845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4J83_RS08865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J83_RS08880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4J83_RS08890	COG1764	response to oxidative stress
C4J83_RS08895	COG1846	Transcriptional regulator
C4J83_RS08900	COG0583	DNA-binding transcription factor activity
C4J83_RS08905	COG0730	response to heat
C4J83_RS08910	COG0583	DNA-binding transcription factor activity
C4J83_RS08920	COG3214	Protein conserved in bacteria
C4J83_RS08925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J83_RS08940	COG1024	Enoyl-CoA hydratase
C4J83_RS08950	COG3384	dioxygenase
C4J83_RS08955	COG0500	methyltransferase
C4J83_RS08960	COG0501	Belongs to the peptidase M48B family
C4J83_RS08965	COG0436	Aminotransferase
C4J83_RS08970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J83_RS08975	COG0386	Belongs to the glutathione peroxidase family
C4J83_RS08980	COG1846	Transcriptional regulator
C4J83_RS08995	COG1956	GAF domain-containing protein
C4J83_RS09000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS09000	COG2205	protein histidine kinase activity
C4J83_RS09005	COG2197	response regulator
C4J83_RS09040	COG0004	ammonium transporteR
C4J83_RS09060	COG0564	pseudouridine synthase activity
C4J83_RS09070	COG0746	molybdenum cofactor guanylyltransferase activity
C4J83_RS09075	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4J83_RS09085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J83_RS09095	COG4133	protoheme IX ABC transporter activity
C4J83_RS09115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4J83_RS09120	COG1138	Cytochrome C-type biogenesis protein
C4J83_RS09130	COG3088	subunit of a heme lyase
C4J83_RS09135	COG4235	cytochrome complex assembly
C4J83_RS09155	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4J83_RS09160	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C4J83_RS09165	COG3639	organic phosphonate transmembrane transporter activity
C4J83_RS09170	COG2188	Transcriptional regulator
C4J83_RS09175	COG3624	Phosphonate C-P lyase system protein PhnG
C4J83_RS09185	COG3626	phosphonate metabolism
C4J83_RS09190	COG3627	carbon phosphorus lyase activity
C4J83_RS09195	COG4107	phosphonate C-P lyase system protein PhnK
C4J83_RS09200	COG4778	phosphonate C-P lyase system protein PhnL
C4J83_RS09205	COG3454	Phosphonate metabolism
C4J83_RS09210	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4J83_RS09215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J83_RS09255	COG2814	Major facilitator Superfamily
C4J83_RS09265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J83_RS09270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J83_RS09280	COG0469	pyruvate kinase activity
C4J83_RS09290	COG2084	Dehydrogenase
C4J83_RS09295	COG3622	Belongs to the hyi family
C4J83_RS09300	COG3960	tartronate-semialdehyde synthase activity
C4J83_RS09315	COG1309	transcriptional regulator
C4J83_RS09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS09330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J83_RS09340	COG2354	Protein conserved in bacteria
C4J83_RS09350	COG2853	Lipoprotein
C4J83_RS09370	COG2113	Glycine betaine
C4J83_RS09375	COG3162	membrane
C4J83_RS09380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J83_RS09390	COG2009	succinate dehydrogenase
C4J83_RS09395	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4J83_RS09400	COG1053	succinate dehydrogenase
C4J83_RS09405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J83_RS09420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J83_RS09425	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J83_RS09460	COG0326	Molecular chaperone. Has ATPase activity
C4J83_RS09470	COG1741	Belongs to the pirin family
C4J83_RS09495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J83_RS09500	COG0784	Response regulator, receiver
C4J83_RS09500	COG2205	protein histidine kinase activity
C4J83_RS09500	COG5002	protein histidine kinase activity
C4J83_RS09515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J83_RS09540	COG1022	Amp-dependent synthetase and ligase
C4J83_RS09565	COG0628	permease
C4J83_RS09580	COG0284	orotidine-5'-phosphate decarboxylase activity
C4J83_RS09585	COG2130	NADP-dependent
C4J83_RS09595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS09600	COG0840	transmembrane signaling receptor activity
C4J83_RS09605	COG2267	carboxylic ester hydrolase activity
C4J83_RS09635	COG0786	glutamate:sodium symporter activity
C4J83_RS09640	COG2197	response regulator
C4J83_RS09645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4J83_RS09705	COG0811	peptide transport
C4J83_RS09730	COG3540	Alkaline phosphatase
C4J83_RS09750	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS09760	COG0625	glutathione transferase activity
C4J83_RS09765	COG1131	(ABC) transporter
C4J83_RS09770	COG0842	Transport permease protein
C4J83_RS09795	COG2076	Multidrug Resistance protein
C4J83_RS09800	COG0385	Bile acid
C4J83_RS09810	COG2974	May be involved in recombination
C4J83_RS09840	COG0477	Major facilitator Superfamily
C4J83_RS09845	COG0583	DNA-binding transcription factor activity
C4J83_RS09850	COG0745	RESPONSE REGULATOR receiver
C4J83_RS09855	COG2205	protein histidine kinase activity
C4J83_RS09865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4J83_RS09870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J83_RS09875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J83_RS09900	COG2010	Cytochrome c
C4J83_RS09905	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J83_RS09925	COG2200	EAL domain
C4J83_RS09935	COG0604	alcohol dehydrogenase
C4J83_RS09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4J83_RS09935	COG3321	synthase
C4J83_RS09935	COG4221	oxidoreductase activity
C4J83_RS09945	COG3842	ATPase activity
C4J83_RS09955	COG0395	ABC-type sugar transport system, permease component
C4J83_RS09980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J83_RS09985	COG1121	(ABC) transporter
C4J83_RS10015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J83_RS10020	COG0066	3-isopropylmalate dehydratase activity
C4J83_RS10025	COG1509	lysine 2,3-aminomutase activity
C4J83_RS10045	COG0583	DNA-binding transcription factor activity
C4J83_RS10050	COG1301	dicarboxylic acid transport
C4J83_RS10055	COG0596	Alpha beta hydrolase
C4J83_RS10070	COG2011	ABC-type metal ion transport system permease component
C4J83_RS10090	COG3829	transcription factor binding
C4J83_RS10100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS10105	COG0431	NADPH-dependent FMN reductase
C4J83_RS10125	COG0583	DNA-binding transcription factor activity
C4J83_RS10150	COG5006	permease, DMT superfamily
C4J83_RS10185	COG0583	DNA-binding transcription factor activity
C4J83_RS10195	COG0768	penicillin binding
C4J83_RS10220	COG0417	DNA replication proofreading
C4J83_RS10245	COG0728	peptidoglycan biosynthetic process
C4J83_RS10290	COG0662	Cupin 2, conserved barrel domain protein
C4J83_RS10290	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J83_RS10305	COG3712	iron ion homeostasis
C4J83_RS10310	COG1595	DNA-templated transcription, initiation
C4J83_RS10325	COG4977	sequence-specific DNA binding
C4J83_RS10330	COG4251	negative regulation of phosphorylation
C4J83_RS10345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J83_RS10355	COG3387	PFAM Glycoside hydrolase 15-related
C4J83_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS10365	COG2207	Transcriptional regulator
C4J83_RS10385	COG1595	DNA-templated transcription, initiation
C4J83_RS10395	COG4772	TonB-dependent receptor
C4J83_RS10415	COG2223	nitrite transmembrane transporter activity
C4J83_RS10440	COG3675	Pfam Lipase (class 3)
C4J83_RS10445	COG0402	S-adenosylhomocysteine deaminase activity
C4J83_RS10455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J83_RS10475	COG0720	synthase
C4J83_RS10505	COG0840	transmembrane signaling receptor activity
C4J83_RS10510	COG2056	Na+-H+ antiporter family
C4J83_RS10525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J83_RS10530	COG0436	Aminotransferase
C4J83_RS10535	COG0826	peptidase U32
C4J83_RS10545	COG0628	permease
C4J83_RS10565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J83_RS10570	COG3132	Protein of unknown function, DUF480
C4J83_RS10580	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4J83_RS10590	COG0583	DNA-binding transcription factor activity
C4J83_RS10600	COG1253	flavin adenine dinucleotide binding
C4J83_RS10605	COG0709	Synthesizes selenophosphate from selenide and ATP
C4J83_RS10610	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4J83_RS10615	COG0701	Predicted permease
C4J83_RS10625	COG0625	glutathione transferase activity
C4J83_RS10630	COG0384	phenazine biosynthesis protein PhzF
C4J83_RS10635	COG0113	porphobilinogen synthase activity
C4J83_RS10650	COG3209	COG3209 Rhs family protein
C4J83_RS10655	COG1280	lysine exporter protein (LysE YggA)
C4J83_RS10685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J83_RS10690	COG0583	DNA-binding transcription factor activity
C4J83_RS10700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4J83_RS10705	COG0517	IMP dehydrogenase activity
C4J83_RS10710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J83_RS10735	COG4335	DNA alkylation repair
C4J83_RS10740	COG0174	glutamine synthetase
C4J83_RS10760	COG2814	Major facilitator Superfamily
C4J83_RS10770	COG3237	CsbD-like
C4J83_RS10785	COG1917	Cupin 2, conserved barrel domain protein
C4J83_RS10785	COG4977	sequence-specific DNA binding
C4J83_RS10790	COG0384	phenazine biosynthesis protein PhzF
C4J83_RS10825	COG2197	response regulator
C4J83_RS10830	COG2205	protein histidine kinase activity
C4J83_RS10830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS10840	COG0656	L-ascorbic acid biosynthetic process
C4J83_RS10855	COG0515	serine threonine protein kinase
C4J83_RS10885	COG1902	pentaerythritol trinitrate reductase activity
C4J83_RS10885	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J83_RS10890	COG0235	Class ii aldolase
C4J83_RS10900	COG1024	Enoyl-CoA hydratase
C4J83_RS10905	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS10935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J83_RS10945	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J83_RS10950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4J83_RS10955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J83_RS10975	COG2197	response regulator
C4J83_RS10980	COG0322	excinuclease ABC activity
C4J83_RS11040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J83_RS11060	COG1063	alcohol dehydrogenase
C4J83_RS11100	COG0300	oxidoreductase activity
C4J83_RS11135	COG2831	hemolysin activation secretion protein
C4J83_RS11140	COG3210	domain, Protein
C4J83_RS11225	COG1595	DNA-templated transcription, initiation
C4J83_RS11235	COG3284	Transcriptional regulator
C4J83_RS11245	COG3842	ATPase activity
C4J83_RS11250	COG3842	ATPase activity
C4J83_RS11260	COG0395	ABC-type sugar transport system, permease component
C4J83_RS11275	COG2207	Transcriptional regulator
C4J83_RS11280	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS11300	COG1063	alcohol dehydrogenase
C4J83_RS11345	COG2814	Major facilitator Superfamily
C4J83_RS11365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J83_RS11375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS11380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS11410	COG0667	Aldo Keto reductase
C4J83_RS11445	COG1741	Belongs to the pirin family
C4J83_RS11465	COG4977	sequence-specific DNA binding
C4J83_RS11465	COG1917	Cupin 2, conserved barrel domain protein
C4J83_RS11500	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4J83_RS11505	COG1335	isochorismatase
C4J83_RS11510	COG0583	DNA-binding transcription factor activity
C4J83_RS11515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J83_RS11520	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS11530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS11535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS11540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J83_RS11550	COG0583	DNA-binding transcription factor activity
C4J83_RS11600	COG2011	ABC-type metal ion transport system permease component
C4J83_RS11625	COG3706	GGDEF domain
C4J83_RS11650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J83_RS11655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS11660	COG2814	Major facilitator Superfamily
C4J83_RS11675	COG1959	2 iron, 2 sulfur cluster binding
C4J83_RS11715	COG2207	Transcriptional regulator
C4J83_RS11755	COG2814	Major facilitator Superfamily
C4J83_RS11780	COG0745	RESPONSE REGULATOR receiver
C4J83_RS11785	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J83_RS11790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J83_RS11795	COG0583	DNA-binding transcription factor activity
C4J83_RS11810	COG2271	Major facilitator Superfamily
C4J83_RS11815	COG1609	Transcriptional regulator
C4J83_RS11835	COG2072	flavoprotein involved in K transport
C4J83_RS11875	COG0583	DNA-binding transcription factor activity
C4J83_RS11885	COG0165	Argininosuccinate lyase
C4J83_RS11895	COG1999	signal sequence binding
C4J83_RS11935	COG0693	protein deglycase activity
C4J83_RS11960	COG1349	DNA-binding transcription factor activity
C4J83_RS11965	COG1304	FMN binding
C4J83_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS11980	COG0494	nUDIX hydrolase
C4J83_RS12000	COG0616	signal peptide processing
C4J83_RS12010	COG0583	DNA-binding transcription factor activity
C4J83_RS12020	COG1253	flavin adenine dinucleotide binding
C4J83_RS12025	COG3118	belongs to the thioredoxin family
C4J83_RS12040	COG0765	amino acid transport
C4J83_RS12045	COG0765	amino acid transport
C4J83_RS12070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J83_RS12095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J83_RS12105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J83_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS12115	COG2610	gluconate transmembrane transporter activity
C4J83_RS12120	COG3829	transcription factor binding
C4J83_RS12120	COG3290	protein histidine kinase activity
C4J83_RS12125	COG4172	Belongs to the ABC transporter superfamily
C4J83_RS12130	COG4239	(ABC) transporter, permease
C4J83_RS12135	COG4174	ABC transporter (Permease)
C4J83_RS12140	COG4166	transmembrane transport
C4J83_RS12145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J83_RS12155	COG4172	Belongs to the ABC transporter superfamily
C4J83_RS12160	COG4239	(ABC) transporter, permease
C4J83_RS12165	COG4174	ABC transporter (Permease)
C4J83_RS12170	COG4166	transmembrane transport
C4J83_RS12175	COG4166	transmembrane transport
C4J83_RS12180	COG0741	lytic transglycosylase activity
C4J83_RS12180	COG1388	LysM domain
C4J83_RS12185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J83_RS12195	COG0328	RNA-DNA hybrid ribonuclease activity
C4J83_RS12200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J83_RS12210	COG0456	acetyltransferase
C4J83_RS12235	COG0431	NADPH-dependent FMN reductase
C4J83_RS12240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J83_RS12245	COG0583	DNA-binding transcription factor activity
C4J83_RS12250	COG0028	Belongs to the TPP enzyme family
C4J83_RS12295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4J83_RS12300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4J83_RS12300	COG0316	Belongs to the HesB IscA family
C4J83_RS12365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS12370	COG0577	efflux transmembrane transporter activity
C4J83_RS12370	COG1136	(ABC) transporter
C4J83_RS12385	COG1522	sequence-specific DNA binding
C4J83_RS12390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS12400	COG2814	Major facilitator Superfamily
C4J83_RS12415	COG0174	glutamine synthetase
C4J83_RS12425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS12430	COG0583	DNA-binding transcription factor activity
C4J83_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS12450	COG2205	protein histidine kinase activity
C4J83_RS12455	COG0745	RESPONSE REGULATOR receiver
C4J83_RS12465	COG2814	Major facilitator Superfamily
C4J83_RS12485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS12490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J83_RS12505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J83_RS12515	COG3718	enzyme involved in inositol metabolism
C4J83_RS12525	COG3962	Belongs to the TPP enzyme family
C4J83_RS12530	COG0673	inositol 2-dehydrogenase activity
C4J83_RS12540	COG1082	Xylose isomerase domain protein TIM barrel
C4J83_RS12545	COG0673	inositol 2-dehydrogenase activity
C4J83_RS12560	COG1129	ABC transporter
C4J83_RS12565	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J83_RS12615	COG4774	siderophore transport
C4J83_RS12640	COG4774	siderophore transport
C4J83_RS12650	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J83_RS12670	COG3706	GGDEF domain
C4J83_RS12670	COG2203	Gaf domain
C4J83_RS12670	COG4251	negative regulation of phosphorylation
C4J83_RS12670	COG5001	Diguanylate cyclase
C4J83_RS12715	COG0673	inositol 2-dehydrogenase activity
C4J83_RS12725	COG2207	Transcriptional regulator
C4J83_RS12740	COG2066	Belongs to the glutaminase family
C4J83_RS12745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J83_RS12755	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS12770	COG0019	diaminopimelate decarboxylase activity
C4J83_RS12775	COG1609	Transcriptional regulator
C4J83_RS12785	COG1175	transmembrane transport
C4J83_RS12795	COG3842	ATPase activity
C4J83_RS12800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J83_RS12845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4J83_RS12850	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C4J83_RS12860	COG0596	Alpha beta hydrolase
C4J83_RS12865	COG0625	glutathione transferase activity
C4J83_RS12895	COG2989	Protein conserved in bacteria
C4J83_RS12910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J83_RS12930	COG0656	L-ascorbic acid biosynthetic process
C4J83_RS12975	COG2204	response regulator
C4J83_RS13055	COG2267	carboxylic ester hydrolase activity
C4J83_RS13060	COG3239	Fatty acid desaturase
C4J83_RS13085	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS13105	COG0318	PFAM AMP-dependent synthetase and ligase
C4J83_RS13120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J83_RS13130	COG1609	Transcriptional regulator
C4J83_RS13145	COG3468	outer membrane autotransporter barrel domain protein
C4J83_RS13155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J83_RS13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS13165	COG0745	RESPONSE REGULATOR receiver
C4J83_RS13170	COG2205	protein histidine kinase activity
C4J83_RS13180	COG1595	DNA-templated transcription, initiation
C4J83_RS13195	COG0730	response to heat
C4J83_RS13215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS13225	COG0189	ligase activity
C4J83_RS13230	COG0598	Magnesium transport protein CorA
C4J83_RS13235	COG0024	Methionine aminopeptidase
C4J83_RS13245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J83_RS13265	COG1070	Carbohydrate kinase
C4J83_RS13285	COG1175	transmembrane transport
C4J83_RS13325	COG1538	Outer membrane efflux protein
C4J83_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS13350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS13355	COG0348	domain, Protein
C4J83_RS13365	COG1285	pathogenesis
C4J83_RS13385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J83_RS13395	COG0784	Response regulator, receiver
C4J83_RS13395	COG4191	Histidine kinase
C4J83_RS13435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J83_RS13440	COG3397	chitin binding
C4J83_RS13445	COG3318	Belongs to the UPF0149 family
C4J83_RS13445	COG3012	SEC-C Motif Domain Protein
C4J83_RS13450	COG0038	chloride channel
C4J83_RS13455	COG1024	Enoyl-CoA hydratase
C4J83_RS13460	COG2816	NAD+ diphosphatase activity
C4J83_RS13495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J83_RS13525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J83_RS13530	COG1595	DNA-templated transcription, initiation
C4J83_RS13535	COG3712	iron ion homeostasis
C4J83_RS13540	COG1116	anion transmembrane transporter activity
C4J83_RS13545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J83_RS13575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4J83_RS13580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J83_RS13590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS13610	COG0583	DNA-binding transcription factor activity
C4J83_RS13625	COG0277	FAD linked oxidase domain protein
C4J83_RS13630	COG0436	Aminotransferase
C4J83_RS13635	COG0765	amino acid transport
C4J83_RS13645	COG1126	abc transporter atp-binding protein
C4J83_RS13655	COG0625	glutathione transferase activity
C4J83_RS13670	COG2271	Major facilitator Superfamily
C4J83_RS13675	COG1335	isochorismatase
C4J83_RS13680	COG3473	Maleate cis-trans isomerase
C4J83_RS13685	COG0596	Alpha beta hydrolase
C4J83_RS13690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J83_RS13695	COG2309	aminopeptidase activity
C4J83_RS13700	COG1846	Transcriptional regulator
C4J83_RS13705	COG2080	2 iron, 2 sulfur cluster binding
C4J83_RS13710	COG2010	Cytochrome c
C4J83_RS13710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J83_RS13715	COG1309	transcriptional regulator
C4J83_RS13730	COG1846	Transcriptional regulator
C4J83_RS13735	COG0708	Exodeoxyribonuclease III
C4J83_RS13740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J83_RS13770	COG0840	transmembrane signaling receptor activity
C4J83_RS13775	COG1968	undecaprenyl-diphosphatase activity
C4J83_RS13790	COG0583	DNA-binding transcription factor activity
C4J83_RS13800	COG2207	Transcriptional regulator
C4J83_RS13805	COG2814	Major facilitator Superfamily
C4J83_RS13810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J83_RS13825	COG0488	(ABC) transporter
C4J83_RS14015	COG4251	negative regulation of phosphorylation
C4J83_RS14015	COG5001	Diguanylate cyclase
C4J83_RS14015	COG2203	Gaf domain
C4J83_RS14015	COG3706	GGDEF domain
C4J83_RS14265	COG2203	Gaf domain
C4J83_RS14265	COG2199	diguanylate cyclase activity
C4J83_RS14275	COG0500	methyltransferase
C4J83_RS14300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4J83_RS14310	COG2133	pyrroloquinoline quinone binding
C4J83_RS14325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J83_RS14335	COG2822	iron ion transport
C4J83_RS14345	COG2822	iron ion transport
C4J83_RS14350	COG0672	)-iron permease
C4J83_RS14355	COG2207	Transcriptional regulator
C4J83_RS14360	COG0076	glutamate decarboxylase activity
C4J83_RS14390	COG1538	Outer membrane efflux protein
C4J83_RS14395	COG2814	Major facilitator Superfamily
C4J83_RS14415	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS14460	COG2814	Major facilitator Superfamily
C4J83_RS14470	COG1024	Enoyl-CoA hydratase
C4J83_RS14470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J83_RS14480	COG3609	addiction module antidote protein, CC2985 family
C4J83_RS14535	COG3321	synthase
C4J83_RS14535	COG0604	alcohol dehydrogenase
C4J83_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS14545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS14560	COG0210	DNA helicase
C4J83_RS14575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS14635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J83_RS14655	COG0513	Belongs to the DEAD box helicase family
C4J83_RS14670	COG2267	carboxylic ester hydrolase activity
C4J83_RS14680	COG0745	RESPONSE REGULATOR receiver
C4J83_RS14685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J83_RS14695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J83_RS14710	COG2308	Evidence 4 Homologs of previously reported genes of
C4J83_RS14735	COG0583	DNA-binding transcription factor activity
C4J83_RS14740	COG0667	Aldo Keto reductase
C4J83_RS14770	COG0697	spore germination
C4J83_RS14775	COG1309	transcriptional regulator
C4J83_RS14790	COG0583	DNA-binding transcription factor activity
C4J83_RS14795	COG1716	ATPase activity
C4J83_RS14795	COG5001	Diguanylate cyclase
C4J83_RS14800	COG0784	Response regulator, receiver
C4J83_RS14805	COG2202	Pas domain
C4J83_RS14805	COG2205	protein histidine kinase activity
C4J83_RS14820	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J83_RS14825	COG1879	ABC-type sugar transport system periplasmic component
C4J83_RS14830	COG1609	Transcriptional regulator
C4J83_RS14835	COG1070	Carbohydrate kinase
C4J83_RS14845	COG0656	L-ascorbic acid biosynthetic process
C4J83_RS14855	COG1522	sequence-specific DNA binding
C4J83_RS14865	COG0826	peptidase U32
C4J83_RS14885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J83_RS14905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J83_RS14915	COG0583	DNA-binding transcription factor activity
C4J83_RS14920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J83_RS14925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS14940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS14950	COG1942	4-Oxalocrotonate Tautomerase
C4J83_RS14960	COG0295	cytidine deaminase activity
C4J83_RS14965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4J83_RS14980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J83_RS15030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J83_RS15040	COG2010	Cytochrome c
C4J83_RS15045	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4J83_RS15045	COG3608	succinylglutamate desuccinylase aspartoacylase
C4J83_RS15050	COG4191	Histidine kinase
C4J83_RS15050	COG0784	Response regulator, receiver
C4J83_RS15055	COG3237	CsbD-like
C4J83_RS15060	COG0586	Pfam SNARE associated Golgi protein
C4J83_RS15070	COG0302	gtp cyclohydrolase
C4J83_RS15105	COG1802	Transcriptional regulator
C4J83_RS15110	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS15120	COG0765	amino acid transport
C4J83_RS15125	COG0765	amino acid transport
C4J83_RS15135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J83_RS15145	COG1942	4-Oxalocrotonate Tautomerase
C4J83_RS15170	COG0583	DNA-binding transcription factor activity
C4J83_RS15180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS15200	COG2814	Major facilitator Superfamily
C4J83_RS15210	COG0583	DNA-binding transcription factor activity
C4J83_RS15215	COG0300	oxidoreductase activity
C4J83_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS15235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4J83_RS15240	COG1349	DNA-binding transcription factor activity
C4J83_RS15250	COG0738	Major facilitator superfamily
C4J83_RS15260	COG2814	Major facilitator Superfamily
C4J83_RS15270	COG0583	DNA-binding transcription factor activity
C4J83_RS15275	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS15280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J83_RS15290	COG0463	Glycosyl transferase, family 2
C4J83_RS15295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J83_RS15295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J83_RS15300	COG0726	polysaccharide deacetylase
C4J83_RS15305	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J83_RS15310	COG2076	Multidrug Resistance protein
C4J83_RS15315	COG2076	Multidrug Resistance protein
C4J83_RS15340	COG1024	Enoyl-CoA hydratase
C4J83_RS15345	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS15350	COG1024	Enoyl-CoA hydratase
C4J83_RS15355	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS15360	COG0183	Belongs to the thiolase family
C4J83_RS15370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J83_RS15375	COG3781	membrane
C4J83_RS15385	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J83_RS15405	COG2205	protein histidine kinase activity
C4J83_RS15405	COG0784	Response regulator, receiver
C4J83_RS15415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J83_RS15420	COG2198	Histidine kinase
C4J83_RS15420	COG2205	protein histidine kinase activity
C4J83_RS15420	COG0784	Response regulator, receiver
C4J83_RS15455	COG1794	racemase activity, acting on amino acids and derivatives
C4J83_RS15460	COG1247	-acetyltransferase
C4J83_RS15465	COG5342	invasion associated locus B
C4J83_RS15470	COG1929	Belongs to the glycerate kinase type-1 family
C4J83_RS15475	COG3835	regulator
C4J83_RS15480	COG2271	Major facilitator Superfamily
C4J83_RS15490	COG0583	DNA-binding transcription factor activity
C4J83_RS15495	COG0667	Aldo Keto reductase
C4J83_RS15515	COG0583	DNA-binding transcription factor activity
C4J83_RS15520	COG2200	EAL domain
C4J83_RS15595	COG3145	DNA-N1-methyladenine dioxygenase activity
C4J83_RS15600	COG2169	Transcriptional regulator
C4J83_RS15600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J83_RS15630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4J83_RS15640	COG0488	(ABC) transporter
C4J83_RS15665	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4J83_RS15675	COG0640	Transcriptional regulator
C4J83_RS15690	COG2207	Transcriptional regulator
C4J83_RS15690	COG1917	Cupin 2, conserved barrel domain protein
C4J83_RS15770	COG0596	Alpha beta hydrolase
C4J83_RS15775	COG5002	protein histidine kinase activity
C4J83_RS15805	COG0583	DNA-binding transcription factor activity
C4J83_RS15815	COG0583	DNA-binding transcription factor activity
C4J83_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS15840	COG0531	amino acid
C4J83_RS15845	COG3938	Belongs to the proline racemase family
C4J83_RS15850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J83_RS15865	COG1397	ADP-ribosylglycohydrolase
C4J83_RS15880	COG2267	carboxylic ester hydrolase activity
C4J83_RS15895	COG1309	transcriptional regulator
C4J83_RS15915	COG0583	DNA-binding transcription factor activity
C4J83_RS15925	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS15985	COG3179	chitinase
C4J83_RS16200	COG4191	Histidine kinase
C4J83_RS16200	COG0784	Response regulator, receiver
C4J83_RS16210	COG2366	antibiotic biosynthetic process
C4J83_RS16225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J83_RS16230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS16235	COG1116	anion transmembrane transporter activity
C4J83_RS16235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS16255	COG0583	DNA-binding transcription factor activity
C4J83_RS16260	COG0667	Aldo Keto reductase
C4J83_RS16265	COG0840	transmembrane signaling receptor activity
C4J83_RS16280	COG1238	metal cluster binding
C4J83_RS16285	COG0596	Alpha beta hydrolase
C4J83_RS16290	COG0596	Alpha beta hydrolase
C4J83_RS16295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J83_RS16300	COG0297	glycogen (starch) synthase activity
C4J83_RS16305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J83_RS16310	COG1640	4-alpha-glucanotransferase
C4J83_RS16370	COG0840	transmembrane signaling receptor activity
C4J83_RS16385	COG1846	Transcriptional regulator
C4J83_RS16400	COG0640	Transcriptional regulator
C4J83_RS16420	COG1024	Enoyl-CoA hydratase
C4J83_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS16465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J83_RS16475	COG0626	cystathionine gamma-synthase activity
C4J83_RS16500	COG1944	ATP diphosphatase activity
C4J83_RS16505	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J83_RS16505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J83_RS16530	COG1309	transcriptional regulator
C4J83_RS16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS16560	COG1335	isochorismatase
C4J83_RS16565	COG0183	Belongs to the thiolase family
C4J83_RS16575	COG0667	Aldo Keto reductase
C4J83_RS16620	COG0583	DNA-binding transcription factor activity
C4J83_RS16655	COG0583	DNA-binding transcription factor activity
C4J83_RS16660	COG0697	spore germination
C4J83_RS16665	COG0456	acetyltransferase
C4J83_RS16665	COG1846	Transcriptional regulator
C4J83_RS16670	COG2271	Major facilitator Superfamily
C4J83_RS16675	COG0519	Catalyzes the synthesis of GMP from XMP
C4J83_RS16695	COG2207	Transcriptional regulator
C4J83_RS16700	COG2223	nitrite transmembrane transporter activity
C4J83_RS16705	COG2199	diguanylate cyclase activity
C4J83_RS16720	COG0154	amidase activity
C4J83_RS16745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS16750	COG0697	spore germination
C4J83_RS16815	COG2079	MmgE PrpD family protein
C4J83_RS16820	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS16825	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C4J83_RS16835	COG0583	DNA-binding transcription factor activity
C4J83_RS16840	COG3791	Glutathione-dependent formaldehyde-activating
C4J83_RS16865	COG2205	protein histidine kinase activity
C4J83_RS16870	COG0745	RESPONSE REGULATOR receiver
C4J83_RS16890	COG0589	response to stress
C4J83_RS16915	COG0814	amino acid
C4J83_RS16930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J83_RS16945	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS16950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS16970	COG2818	Glycosylase
C4J83_RS17005	COG0714	Associated with various cellular activities
C4J83_RS17045	COG0420	3'-5' exonuclease activity
C4J83_RS17065	COG2706	6-phosphogluconolactonase activity
C4J83_RS17090	COG0673	inositol 2-dehydrogenase activity
C4J83_RS17100	COG2233	PERMEase
C4J83_RS17120	COG0583	DNA-binding transcription factor activity
C4J83_RS17185	COG2204	response regulator
C4J83_RS17195	COG0561	phosphatase activity
C4J83_RS17200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4J83_RS17205	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J83_RS17210	COG2194	sulfuric ester hydrolase activity
C4J83_RS17225	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J83_RS17240	COG0667	Aldo Keto reductase
C4J83_RS17245	COG0308	aminopeptidase N
C4J83_RS17255	COG3139	Protein of unknown function (DUF1315)
C4J83_RS17265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J83_RS17270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4J83_RS17340	COG1309	transcriptional regulator
C4J83_RS17345	COG0534	Mate efflux family protein
C4J83_RS17360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J83_RS17425	COG1414	Transcriptional regulator
C4J83_RS17430	COG3842	ATPase activity
C4J83_RS17435	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J83_RS17440	COG1177	transmembrane transport
C4J83_RS17465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J83_RS17560	COG0583	DNA-binding transcription factor activity
C4J83_RS17575	COG2207	Transcriptional regulator
C4J83_RS17655	COG0583	DNA-binding transcription factor activity
C4J83_RS17670	COG0318	PFAM AMP-dependent synthetase and ligase
C4J83_RS17685	COG0688	phosphatidylethanolamine metabolic process
C4J83_RS17700	COG1971	Probably functions as a manganese efflux pump
C4J83_RS17705	COG1064	alcohol dehydrogenase
C4J83_RS17715	COG3321	synthase
C4J83_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS17715	COG0604	alcohol dehydrogenase
C4J83_RS17720	COG1902	pentaerythritol trinitrate reductase activity
C4J83_RS17730	COG1309	transcriptional regulator
C4J83_RS17745	COG1968	undecaprenyl-diphosphatase activity
C4J83_RS17755	COG0430	RNA-3'-phosphate cyclase activity
C4J83_RS17760	COG3541	Predicted nucleotidyltransferase
C4J83_RS17765	COG1690	Belongs to the RtcB family
C4J83_RS17770	COG4650	regulator
C4J83_RS17780	COG0625	glutathione transferase activity
C4J83_RS17815	COG2207	Transcriptional regulator
C4J83_RS17840	COG1879	ABC-type sugar transport system periplasmic component
C4J83_RS17850	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS17905	COG3781	membrane
C4J83_RS17940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J83_RS18020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C4J83_RS18025	COG2267	carboxylic ester hydrolase activity
C4J83_RS18065	COG2135	peptidase activity
C4J83_RS18120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4J83_RS18125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J83_RS18130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4J83_RS18135	COG2835	tetraacyldisaccharide 4'-kinase activity
C4J83_RS18140	COG1663	tetraacyldisaccharide 4'-kinase activity
C4J83_RS18150	COG0811	peptide transport
C4J83_RS18155	COG0658	competence protein
C4J83_RS18155	COG2333	competence protein COMEC
C4J83_RS18175	COG2205	protein histidine kinase activity
C4J83_RS18175	COG5002	protein histidine kinase activity
C4J83_RS18175	COG0784	Response regulator, receiver
C4J83_RS18180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J83_RS18200	COG1393	Belongs to the ArsC family
C4J83_RS18220	COG0037	tRNA processing
C4J83_RS18230	COG3091	SprT-like family
C4J83_RS18235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J83_RS18260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J83_RS18265	COG0435	Glutathione S-transferase
C4J83_RS18270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J83_RS18270	COG1648	precorrin-2 dehydrogenase activity
C4J83_RS18275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4J83_RS18280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J83_RS18285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4J83_RS18290	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4J83_RS18295	COG1674	ftsk spoiiie
C4J83_RS18300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4J83_RS18305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4J83_RS18310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4J83_RS18315	COG0542	response to heat
C4J83_RS18320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4J83_RS18325	COG1278	Cold shock
C4J83_RS18345	COG0482	sulfurtransferase activity
C4J83_RS18350	COG2915	High frequency lysogenization protein hflD homolog
C4J83_RS18360	COG2850	peptidyl-arginine hydroxylation
C4J83_RS18365	COG2153	protein acetylation
C4J83_RS18375	COG2224	Isocitrate lyase
C4J83_RS18385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J83_RS18390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J83_RS18395	COG0649	NAD binding
C4J83_RS18395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J83_RS18410	COG1034	ATP synthesis coupled electron transport
C4J83_RS18415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J83_RS18420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J83_RS18430	COG0713	ATP synthesis coupled electron transport
C4J83_RS18445	COG1007	ATP synthesis coupled electron transport
C4J83_RS18565	COG5383	Protein conserved in bacteria
C4J83_RS18585	COG4191	Histidine kinase
C4J83_RS18585	COG0784	Response regulator, receiver
C4J83_RS18590	COG0587	DNA-directed DNA polymerase activity
C4J83_RS18605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4J83_RS18615	COG0277	FAD linked oxidase domain protein
C4J83_RS18660	COG2814	Major facilitator Superfamily
C4J83_RS18670	COG3220	belongs to the UPF0276 family
C4J83_RS18720	COG4792	protein secretion
C4J83_RS18725	COG4791	protein targeting
C4J83_RS18735	COG4790	Type iii secretion
C4J83_RS18740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J83_RS18800	COG4964	Belongs to the GSP D family
C4J83_RS18805	COG4789	Type iii secretion
C4J83_RS18850	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS18875	COG0577	efflux transmembrane transporter activity
C4J83_RS18875	COG1136	(ABC) transporter
C4J83_RS18880	COG1136	(ABC) transporter
C4J83_RS18880	COG0577	efflux transmembrane transporter activity
C4J83_RS18890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS18955	COG2111	Na H antiporter
C4J83_RS18955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J83_RS18960	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J83_RS18965	COG0651	ATP synthesis coupled electron transport
C4J83_RS18970	COG1863	multisubunit Na H antiporter MnhE subunit
C4J83_RS18975	COG2212	antiporter activity
C4J83_RS18980	COG1320	monovalent cation:proton antiporter activity
C4J83_RS18995	COG3340	Belongs to the peptidase S51 family
C4J83_RS19005	COG0215	cysteine-tRNA ligase activity
C4J83_RS19010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J83_RS19020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J83_RS19025	COG2814	Major facilitator Superfamily
C4J83_RS19030	COG1566	PFAM secretion protein HlyD family protein
C4J83_RS19040	COG1846	Transcriptional regulator
C4J83_RS19050	COG0729	surface antigen
C4J83_RS19060	COG0708	Exodeoxyribonuclease III
C4J83_RS19065	COG2885	chlorophyll binding
C4J83_RS19070	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS19080	COG0789	Transcriptional regulator
C4J83_RS19090	COG0318	PFAM AMP-dependent synthetase and ligase
C4J83_RS19095	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS19100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J83_RS19105	COG1024	Enoyl-CoA hydratase
C4J83_RS19125	COG2866	Carboxypeptidase
C4J83_RS19130	COG3038	cytochrome b561
C4J83_RS19185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J83_RS19195	COG0217	transcriptional regulatory protein
C4J83_RS19200	COG0583	DNA-binding transcription factor activity
C4J83_RS19205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J83_RS19210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J83_RS19215	COG3038	cytochrome b561
C4J83_RS19225	COG1902	pentaerythritol trinitrate reductase activity
C4J83_RS19225	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J83_RS19240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J83_RS19245	COG1846	Transcriptional regulator
C4J83_RS19250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J83_RS19270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J83_RS19275	COG0776	regulation of translation
C4J83_RS19280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J83_RS19285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4J83_RS19290	COG0740	serine-type endopeptidase activity
C4J83_RS19295	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4J83_RS19320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4J83_RS19330	COG1686	Belongs to the peptidase S11 family
C4J83_RS19350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS19370	COG1953	Uracil, thiamine, allantoin
C4J83_RS19380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J83_RS19380	COG0493	'glutamate synthase
C4J83_RS19395	COG1309	transcriptional regulator
C4J83_RS19410	COG1276	copper resistance
C4J83_RS19420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J83_RS19430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4J83_RS19470	COG0640	Transcriptional regulator
C4J83_RS19480	COG1522	sequence-specific DNA binding
C4J83_RS19485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J83_RS19490	COG0022	dehydrogenase e1 component
C4J83_RS19500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J83_RS19505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J83_RS19510	COG0456	acetyltransferase
C4J83_RS19535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS19540	COG0577	efflux transmembrane transporter activity
C4J83_RS19540	COG1136	(ABC) transporter
C4J83_RS19570	COG1609	Transcriptional regulator
C4J83_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS19580	COG1070	Carbohydrate kinase
C4J83_RS19585	COG1063	alcohol dehydrogenase
C4J83_RS19590	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J83_RS19600	COG1879	ABC-type sugar transport system periplasmic component
C4J83_RS19645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J83_RS19650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J83_RS19665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J83_RS19670	COG0601	transmembrane transport
C4J83_RS19675	COG0747	negative chemotaxis
C4J83_RS19685	COG3191	aminopeptidase activity
C4J83_RS19690	COG4206	TonB-dependent receptor
C4J83_RS19695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS19700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4J83_RS19705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS19710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS19760	COG0583	DNA-binding transcription factor activity
C4J83_RS19765	COG0583	DNA-binding transcription factor activity
C4J83_RS19770	COG0625	glutathione transferase activity
C4J83_RS19775	COG0583	DNA-binding transcription factor activity
C4J83_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS19790	COG1063	alcohol dehydrogenase
C4J83_RS19795	COG0390	transport system, permease component
C4J83_RS19800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J83_RS19805	COG0667	Aldo Keto reductase
C4J83_RS19820	COG0243	molybdopterin cofactor binding
C4J83_RS19840	COG2205	protein histidine kinase activity
C4J83_RS19840	COG0784	Response regulator, receiver
C4J83_RS19845	COG2203	Gaf domain
C4J83_RS19845	COG2199	diguanylate cyclase activity
C4J83_RS19845	COG2200	EAL domain
C4J83_RS19850	COG0784	Response regulator, receiver
C4J83_RS19850	COG2205	protein histidine kinase activity
C4J83_RS19855	COG2197	response regulator
C4J83_RS19865	COG3121	Chaperone
C4J83_RS19895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS19905	COG1231	oxidoreductase activity
C4J83_RS19910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS19915	COG1126	abc transporter atp-binding protein
C4J83_RS19935	COG1450	Type ii and iii secretion system protein
C4J83_RS19955	COG3156	type II secretion system protein K
C4J83_RS19975	COG2165	general secretion pathway protein
C4J83_RS19980	COG1459	type II secretion system
C4J83_RS19985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J83_RS19990	COG1609	Transcriptional regulator
C4J83_RS20000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS20005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS20010	COG1120	ATPase activity
C4J83_RS20015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J83_RS20020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J83_RS20025	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C4J83_RS20030	COG4774	siderophore transport
C4J83_RS20055	COG0776	regulation of translation
C4J83_RS20060	COG0072	phenylalanine-tRNA ligase activity
C4J83_RS20065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J83_RS20070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4J83_RS20075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4J83_RS20080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4J83_RS20085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J83_RS20095	COG1278	Cold shock
C4J83_RS20120	COG1869	D-ribose catabolic process
C4J83_RS20125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J83_RS20130	COG1609	Transcriptional regulator
C4J83_RS20135	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J83_RS20140	COG1129	ABC transporter
C4J83_RS20145	COG1879	ABC-type sugar transport system periplasmic component
C4J83_RS20170	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J83_RS20185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J83_RS20225	COG0454	-acetyltransferase
C4J83_RS20230	COG1940	carbohydrate kinase activity
C4J83_RS20240	COG1940	carbohydrate kinase activity
C4J83_RS20245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J83_RS20250	COG0477	Major facilitator Superfamily
C4J83_RS20270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS20305	COG1286	toxin biosynthetic process
C4J83_RS20310	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J83_RS20315	COG0285	dihydrofolate synthase activity
C4J83_RS20320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4J83_RS20325	COG0135	phosphoribosylanthranilate isomerase activity
C4J83_RS20350	COG0473	3-isopropylmalate dehydrogenase activity
C4J83_RS20355	COG2226	methyltransferase
C4J83_RS20360	COG0066	3-isopropylmalate dehydratase activity
C4J83_RS20365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J83_RS20395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J83_RS20405	COG0596	Alpha beta hydrolase
C4J83_RS20440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J83_RS20445	COG0556	nucleotide-excision repair
C4J83_RS20460	COG0583	DNA-binding transcription factor activity
C4J83_RS20465	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS20475	COG2205	protein histidine kinase activity
C4J83_RS20480	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J83_RS20490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J83_RS20495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J83_RS20500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J83_RS20530	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4J83_RS20580	COG1280	lysine exporter protein (LysE YggA)
C4J83_RS20595	COG4172	Belongs to the ABC transporter superfamily
C4J83_RS20600	COG4239	(ABC) transporter, permease
C4J83_RS20605	COG4174	ABC transporter (Permease)
C4J83_RS20610	COG4166	transmembrane transport
C4J83_RS20615	COG4206	TonB-dependent receptor
C4J83_RS20615	COG4206	TonB-dependent receptor
C4J83_RS20620	COG4771	TonB-dependent receptor
C4J83_RS20625	COG3712	iron ion homeostasis
C4J83_RS20630	COG1595	DNA-templated transcription, initiation
C4J83_RS20660	COG0124	histidyl-tRNA synthetase
C4J83_RS20670	COG2384	SAM-dependent methyltransferase
C4J83_RS20675	COG2186	Transcriptional regulator
C4J83_RS20695	COG3657	addiction module killer protein
C4J83_RS20700	COG4521	taurine ABC transporter
C4J83_RS20725	COG0235	Class ii aldolase
C4J83_RS20735	COG5285	phytanoyl-CoA dioxygenase
C4J83_RS20740	COG1126	abc transporter atp-binding protein
C4J83_RS20745	COG0583	DNA-binding transcription factor activity
C4J83_RS20790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J83_RS20800	COG0730	response to heat
C4J83_RS20805	COG1104	cysteine desulfurase activity
C4J83_RS20855	COG0402	S-adenosylhomocysteine deaminase activity
C4J83_RS20865	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4J83_RS20875	COG0583	DNA-binding transcription factor activity
C4J83_RS20885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS20890	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J83_RS20915	COG0477	Major facilitator Superfamily
C4J83_RS20920	COG1984	allophanate hydrolase subunit 2
C4J83_RS20925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4J83_RS20940	COG2391	methyltransferase activity
C4J83_RS20950	COG1335	isochorismatase
C4J83_RS20965	COG4993	Dehydrogenase
C4J83_RS20970	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS20975	COG0583	DNA-binding transcription factor activity
C4J83_RS20980	COG2814	Major facilitator Superfamily
C4J83_RS20985	COG1309	transcriptional regulator
C4J83_RS21010	COG4772	TonB-dependent receptor
C4J83_RS21015	COG3712	iron ion homeostasis
C4J83_RS21020	COG1595	DNA-templated transcription, initiation
C4J83_RS21030	COG0583	DNA-binding transcription factor activity
C4J83_RS21035	COG1304	FMN binding
C4J83_RS21050	COG5001	Diguanylate cyclase
C4J83_RS21050	COG5002	protein histidine kinase activity
C4J83_RS21065	COG1054	Belongs to the UPF0176 family
C4J83_RS21070	COG0271	Belongs to the BolA IbaG family
C4J83_RS21080	COG0114	fumarate hydratase activity
C4J83_RS21090	COG0697	spore germination
C4J83_RS21095	COG0183	Belongs to the thiolase family
C4J83_RS21100	COG2326	polyphosphate kinase activity
C4J83_RS21105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS21105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4J83_RS21115	COG0367	asparagine synthase
C4J83_RS21120	COG0189	ligase activity
C4J83_RS21120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J83_RS21135	COG3089	Belongs to the UPF0270 family
C4J83_RS21140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J83_RS21155	COG1368	sulfuric ester hydrolase activity
C4J83_RS21175	COG0318	PFAM AMP-dependent synthetase and ligase
C4J83_RS21185	COG2197	response regulator
C4J83_RS21190	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4J83_RS21200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4J83_RS21205	COG1073	alpha beta
C4J83_RS21230	COG2840	Smr protein MutS2
C4J83_RS21235	COG0302	gtp cyclohydrolase
C4J83_RS21255	COG2851	Citrate transporter
C4J83_RS21260	COG0583	DNA-binding transcription factor activity
C4J83_RS21265	COG0625	glutathione transferase activity
C4J83_RS21270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS21280	COG2252	PERMEase
C4J83_RS21310	COG4266	Belongs to the allantoicase family
C4J83_RS21315	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4J83_RS21325	COG2233	PERMEase
C4J83_RS21340	COG1560	Kdo2-lipid A biosynthetic process
C4J83_RS21345	COG0850	regulation of cytokinetic process
C4J83_RS21350	COG2894	cell division
C4J83_RS21355	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4J83_RS21360	COG0564	pseudouridine synthase activity
C4J83_RS21365	COG1362	aminopeptidase activity
C4J83_RS21370	COG0668	transmembrane transport
C4J83_RS21375	COG1473	amidohydrolase
C4J83_RS21400	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J83_RS21420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J83_RS21430	COG3469	chitinase activity
C4J83_RS21435	COG3397	chitin binding
C4J83_RS21475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J83_RS21480	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS21485	COG1024	Enoyl-CoA hydratase
C4J83_RS21500	COG3123	guanosine phosphorylase activity
C4J83_RS21505	COG3217	Mosc domain protein beta barrel domain protein
C4J83_RS21505	COG0633	Ferredoxin
C4J83_RS21520	COG3851	Histidine kinase
C4J83_RS21525	COG2197	response regulator
C4J83_RS21530	COG1597	lipid kinase activity
C4J83_RS21540	COG0835	chemotaxis
C4J83_RS21550	COG1192	Involved in chromosome partitioning
C4J83_RS21555	COG1360	Flagellar Motor Protein
C4J83_RS21560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4J83_RS21565	COG2201	protein-glutamate methylesterase activity
C4J83_RS21570	COG0784	Response regulator, receiver
C4J83_RS21570	COG2198	Histidine kinase
C4J83_RS21570	COG0643	Histidine kinase
C4J83_RS21575	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4J83_RS21605	COG1278	Cold shock
C4J83_RS21615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J83_RS21700	COG1677	Flagellar hook-basal body complex protein FliE
C4J83_RS21755	COG1256	bacterial-type flagellum assembly
C4J83_RS21765	COG1706	bacterial-type flagellum-dependent cell motility
C4J83_RS21770	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4J83_RS21780	COG4787	bacterial-type flagellum-dependent cell motility
C4J83_RS21795	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4J83_RS21810	COG2207	Transcriptional regulator
C4J83_RS21825	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4J83_RS21830	COG1846	Transcriptional regulator
C4J83_RS21835	COG0514	ATP-dependent DNA helicase (RecQ)
C4J83_RS21845	COG2832	Protein of unknown function (DUF454)
C4J83_RS21850	COG0784	Response regulator, receiver
C4J83_RS21850	COG2205	protein histidine kinase activity
C4J83_RS21900	COG1846	Transcriptional regulator
C4J83_RS21905	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4J83_RS21910	COG0406	alpha-ribazole phosphatase activity
C4J83_RS21915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J83_RS21925	COG1492	cobalamin metabolic process
C4J83_RS21935	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4J83_RS21940	COG0778	Nitroreductase
C4J83_RS21945	COG1797	cobyrinic acid a,c-diamide synthase activity
C4J83_RS21960	COG0791	NLP P60 protein
C4J83_RS21965	COG0791	NLP P60 protein
C4J83_RS21970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J83_RS21975	COG0628	permease
C4J83_RS21985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4J83_RS21990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4J83_RS22005	COG3122	Protein conserved in bacteria
C4J83_RS22010	COG3956	TIGRFAM MazG family protein
C4J83_RS22015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J83_RS22020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J83_RS22055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J83_RS22060	COG0583	DNA-binding transcription factor activity
C4J83_RS22070	COG1953	Uracil, thiamine, allantoin
C4J83_RS22080	COG2996	Protein conserved in bacteria
C4J83_RS22110	COG0513	Belongs to the DEAD box helicase family
C4J83_RS22115	COG0668	transmembrane transport
C4J83_RS22125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J83_RS22150	COG1132	(ABC) transporter
C4J83_RS22155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J83_RS22165	COG2188	Transcriptional regulator
C4J83_RS22175	COG1595	DNA-templated transcription, initiation
C4J83_RS22185	COG1643	Atp-dependent helicase
C4J83_RS22190	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4J83_RS22195	COG0840	transmembrane signaling receptor activity
C4J83_RS22215	COG0463	Glycosyl transferase, family 2
C4J83_RS22230	COG1216	Glycosyl transferase, family 2
C4J83_RS22230	COG0438	transferase activity, transferring glycosyl groups
C4J83_RS22280	COG0840	transmembrane signaling receptor activity
C4J83_RS22290	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J83_RS22305	COG2010	Cytochrome c
C4J83_RS22310	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J83_RS22325	COG2010	Cytochrome c
C4J83_RS22330	COG0348	domain, Protein
C4J83_RS22365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J83_RS22370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J83_RS22375	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS22380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4J83_RS22385	COG2130	NADP-dependent
C4J83_RS22390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4J83_RS22395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4J83_RS22415	COG0583	DNA-binding transcription factor activity
C4J83_RS22455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J83_RS22460	COG3115	cell septum assembly
C4J83_RS22480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J83_RS22490	COG0402	S-adenosylhomocysteine deaminase activity
C4J83_RS22495	COG1802	Transcriptional regulator
C4J83_RS22500	COG3135	benzoate transporter
C4J83_RS22505	COG3171	Protein conserved in bacteria
C4J83_RS22520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J83_RS22520	COG0116	Belongs to the methyltransferase superfamily
C4J83_RS22525	COG3130	regulation of translation
C4J83_RS22530	COG0167	dihydroorotate dehydrogenase activity
C4J83_RS22550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS22550	COG1116	anion transmembrane transporter activity
C4J83_RS22555	COG3707	response regulator
C4J83_RS22560	COG2223	nitrite transmembrane transporter activity
C4J83_RS22570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J83_RS22575	COG2146	nitrite reductase [NAD(P)H] activity
C4J83_RS22580	COG0243	molybdopterin cofactor binding
C4J83_RS22585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J83_RS22590	COG2885	chlorophyll binding
C4J83_RS22590	COG3047	cAMP biosynthetic process
C4J83_RS22615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J83_RS22630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4J83_RS22635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS22650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J83_RS22655	COG1045	serine acetyltransferase
C4J83_RS22660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J83_RS22675	COG1116	anion transmembrane transporter activity
C4J83_RS22680	COG2079	MmgE PrpD family protein
C4J83_RS22690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4J83_RS22695	COG0372	Belongs to the citrate synthase family
C4J83_RS22705	COG1802	Transcriptional regulator
C4J83_RS22710	COG4067	protein conserved in archaea
C4J83_RS22710	COG0189	ligase activity
C4J83_RS22720	COG0189	ligase activity
C4J83_RS22725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J83_RS22730	COG0560	Phosphoserine phosphatase
C4J83_RS22740	COG1953	Uracil, thiamine, allantoin
C4J83_RS22750	COG0583	DNA-binding transcription factor activity
C4J83_RS22755	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS22760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J83_RS22765	COG0300	oxidoreductase activity
C4J83_RS22770	COG0583	DNA-binding transcription factor activity
C4J83_RS22845	COG0598	Magnesium transport protein CorA
C4J83_RS22850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J83_RS22850	COG0519	Catalyzes the synthesis of GMP from XMP
C4J83_RS22855	COG1024	Enoyl-CoA hydratase
C4J83_RS22855	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J83_RS22860	COG0183	Belongs to the thiolase family
C4J83_RS22870	COG1305	Transglutaminase-like
C4J83_RS22880	COG2308	Evidence 4 Homologs of previously reported genes of
C4J83_RS22910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS22915	COG2885	chlorophyll binding
C4J83_RS22950	COG2207	Transcriptional regulator
C4J83_RS22955	COG1064	alcohol dehydrogenase
C4J83_RS22960	COG1414	Transcriptional regulator
C4J83_RS22965	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J83_RS22970	COG1129	ABC transporter
C4J83_RS22975	COG1879	ABC-type sugar transport system periplasmic component
C4J83_RS22980	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS23025	COG1397	ADP-ribosylglycohydrolase
C4J83_RS23030	COG2188	Transcriptional regulator
C4J83_RS23045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J83_RS23055	COG0084	hydrolase, TatD family'
C4J83_RS23065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J83_RS23070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4J83_RS23080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J83_RS23085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J83_RS23100	COG0416	fatty acid biosynthetic process
C4J83_RS23105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4J83_RS23115	COG0424	maF-like protein
C4J83_RS23120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J83_RS23120	COG0616	signal peptide processing
C4J83_RS23125	COG0546	phosphoglycolate phosphatase activity
C4J83_RS23135	COG1530	ribonuclease E activity
C4J83_RS23140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J83_RS23145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4J83_RS23145	COG3608	succinylglutamate desuccinylase aspartoacylase
C4J83_RS23150	COG1301	dicarboxylic acid transport
C4J83_RS23155	COG4977	sequence-specific DNA binding
C4J83_RS23155	COG1917	Cupin 2, conserved barrel domain protein
C4J83_RS23180	COG2205	protein histidine kinase activity
C4J83_RS23185	COG0745	RESPONSE REGULATOR receiver
C4J83_RS23205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4J83_RS23210	COG1558	bacterial-type flagellum-dependent cell motility
C4J83_RS23215	COG1815	bacterial-type flagellum-dependent cell motility
C4J83_RS23220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J83_RS23225	COG0835	chemotaxis
C4J83_RS23225	COG0784	Response regulator, receiver
C4J83_RS23245	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4J83_RS23250	COG0477	Major facilitator Superfamily
C4J83_RS23280	COG2239	Acts as a magnesium transporter
C4J83_RS23300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J83_RS23305	COG0527	aspartate kinase activity
C4J83_RS23310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J83_RS23315	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4J83_RS23320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J83_RS23330	COG2988	succinylglutamate desuccinylase activity
C4J83_RS23340	COG3724	N-succinylarginine dihydrolase activity
C4J83_RS23345	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS23360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J83_RS23395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS23400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J83_RS23410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J83_RS23430	COG0165	Argininosuccinate lyase
C4J83_RS23435	COG0765	amino acid transport
C4J83_RS23450	COG2814	Major facilitator Superfamily
C4J83_RS23465	COG0563	adenylate kinase activity
C4J83_RS23475	COG4221	oxidoreductase activity
C4J83_RS23495	COG3706	GGDEF domain
C4J83_RS23510	COG0583	DNA-binding transcription factor activity
C4J83_RS23515	COG0504	CTP synthase activity
C4J83_RS23520	COG2329	Antibiotic biosynthesis monooxygenase
C4J83_RS23530	COG0584	glycerophosphoryl diester phosphodiesterase
C4J83_RS23550	COG0306	phosphate transporter
C4J83_RS23555	COG1984	allophanate hydrolase subunit 2
C4J83_RS23565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4J83_RS23575	COG0583	DNA-binding transcription factor activity
C4J83_RS23580	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS23595	COG0583	DNA-binding transcription factor activity
C4J83_RS23600	COG0583	DNA-binding transcription factor activity
C4J83_RS23605	COG4221	oxidoreductase activity
C4J83_RS23610	COG4941	Belongs to the sigma-70 factor family
C4J83_RS23620	COG3795	YCII-related domain
C4J83_RS23645	COG0436	Aminotransferase
C4J83_RS23655	COG3265	gluconokinase activity
C4J83_RS23660	COG1609	Transcriptional regulator
C4J83_RS23670	COG0583	DNA-binding transcription factor activity
C4J83_RS23685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J83_RS23690	COG2271	Major facilitator Superfamily
C4J83_RS23705	COG0583	DNA-binding transcription factor activity
C4J83_RS23710	COG0625	glutathione transferase activity
C4J83_RS23730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS23745	COG3712	iron ion homeostasis
C4J83_RS23750	COG1595	DNA-templated transcription, initiation
C4J83_RS23775	COG0242	peptide deformylase activity
C4J83_RS23780	COG1295	ribonuclease BN
C4J83_RS23800	COG0318	PFAM AMP-dependent synthetase and ligase
C4J83_RS23810	COG2030	dehydratase
C4J83_RS23820	COG3530	Putative quorum-sensing-regulated virulence factor
C4J83_RS23825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J83_RS23835	COG0800	Aldolase
C4J83_RS23850	COG1737	Transcriptional regulator
C4J83_RS23855	COG0676	glucose-6-phosphate 1-epimerase activity
C4J83_RS23865	COG3842	ATPase activity
C4J83_RS23875	COG1175	transmembrane transport
C4J83_RS23880	COG1653	transport
C4J83_RS23895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J83_RS23900	COG0583	DNA-binding transcription factor activity
C4J83_RS23915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4J83_RS23935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4J83_RS23970	COG1113	amino acid transport
C4J83_RS23995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4J83_RS24005	COG0009	L-threonylcarbamoyladenylate synthase
C4J83_RS24015	COG2917	probably involved in intracellular septation
C4J83_RS24020	COG2350	Protein conserved in bacteria
C4J83_RS24030	COG0745	RESPONSE REGULATOR receiver
C4J83_RS24050	COG0642	Histidine kinase
C4J83_RS24105	COG0509	glycine decarboxylation via glycine cleavage system
C4J83_RS24110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J83_RS24110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J83_RS24115	COG1760	l-serine dehydratase
C4J83_RS24120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J83_RS24125	COG1278	Cold shock
C4J83_RS24135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4J83_RS24170	COG0573	inorganic phosphate transmembrane transporter activity
C4J83_RS24180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J83_RS24190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4J83_RS24195	COG0602	queuosine metabolic process
C4J83_RS24200	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4J83_RS24205	COG2885	chlorophyll binding
C4J83_RS24210	COG0823	Involved in the tonB-independent uptake of proteins
C4J83_RS24230	COG0824	Thioesterase
C4J83_RS24235	COG2255	four-way junction helicase activity
C4J83_RS24240	COG0632	four-way junction helicase activity
C4J83_RS24245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4J83_RS24250	COG0217	transcriptional regulatory protein
C4J83_RS24255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4J83_RS24270	COG0783	Belongs to the Dps family
C4J83_RS24280	COG2900	Belongs to the SlyX family
C4J83_RS24295	COG0668	transmembrane transport
C4J83_RS24300	COG1666	GTP binding
C4J83_RS24310	COG4191	Histidine kinase
C4J83_RS24310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS24315	COG2096	Adenosyltransferase
C4J83_RS24330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4J83_RS24335	COG0653	protein targeting
C4J83_RS24345	COG0433	COG0433 Predicted ATPase
C4J83_RS24355	COG0788	formyltetrahydrofolate deformylase activity
C4J83_RS24370	COG2925	Exonuclease
C4J83_RS24395	COG0714	Associated with various cellular activities
C4J83_RS24415	COG0469	pyruvate kinase activity
C4J83_RS24420	COG1024	Enoyl-CoA hydratase
C4J83_RS24440	COG4191	Histidine kinase
C4J83_RS24450	COG0477	Major facilitator Superfamily
C4J83_RS24475	COG2207	Transcriptional regulator
C4J83_RS24510	COG1595	DNA-templated transcription, initiation
C4J83_RS24515	COG3712	iron ion homeostasis
C4J83_RS24520	COG4771	TonB-dependent receptor
C4J83_RS24530	COG2832	Protein of unknown function (DUF454)
C4J83_RS24535	COG0840	transmembrane signaling receptor activity
C4J83_RS24565	COG3642	lipopolysaccharide core region biosynthetic process
C4J83_RS24590	COG0459	protein refolding
C4J83_RS24595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4J83_RS24625	COG0442	prolyl-tRNA aminoacylation
C4J83_RS24635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4J83_RS24675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J83_RS24710	COG4974	Belongs to the 'phage' integrase family
C4J83_RS24715	COG1607	acyl-coa hydrolase
C4J83_RS24720	COG0335	large ribosomal subunit rRNA binding
C4J83_RS24725	COG0336	Belongs to the RNA methyltransferase TrmD family
C4J83_RS24730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4J83_RS24735	COG0228	four-way junction DNA binding
C4J83_RS24740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4J83_RS24750	COG4536	flavin adenine dinucleotide binding
C4J83_RS24755	COG0477	Major facilitator Superfamily
C4J83_RS24760	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4J83_RS24780	COG0494	nUDIX hydrolase
C4J83_RS24795	COG2188	Transcriptional regulator
C4J83_RS24800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4J83_RS24805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J83_RS24810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J83_RS24810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J83_RS24815	COG2190	(PTS) system
C4J83_RS24815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J83_RS24815	COG1263	PTS System
C4J83_RS24825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4J83_RS24830	COG0047	phosphoribosylformylglycinamidine synthase activity
C4J83_RS24830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J83_RS24835	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J83_RS24840	COG1263	PTS System
C4J83_RS24840	COG2190	(PTS) system
C4J83_RS24840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J83_RS24845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J83_RS24845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J83_RS24855	COG4580	involved in the transport of maltose and maltodextrins
C4J83_RS24860	COG0366	Alpha amylase catalytic
C4J83_RS24865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J83_RS24865	COG1263	PTS System
C4J83_RS24870	COG2188	Transcriptional regulator
C4J83_RS24880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J83_RS24880	COG0519	Catalyzes the synthesis of GMP from XMP
C4J83_RS24900	COG0583	DNA-binding transcription factor activity
C4J83_RS24905	COG1570	exodeoxyribonuclease VII activity
C4J83_RS24910	COG0739	heme binding
C4J83_RS24920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J83_RS24925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J83_RS24930	COG0436	Aminotransferase
C4J83_RS24935	COG1160	GTP binding
C4J83_RS24950	COG0124	histidyl-tRNA synthetase
C4J83_RS24955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J83_RS24960	COG1426	Protein conserved in bacteria
C4J83_RS24970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4J83_RS24975	COG0105	UTP biosynthetic process
C4J83_RS24985	COG0633	Ferredoxin
C4J83_RS24990	COG0443	Heat shock 70 kDa protein
C4J83_RS24995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J83_RS25000	COG0316	Belongs to the HesB IscA family
C4J83_RS25010	COG1104	cysteine desulfurase activity
C4J83_RS25035	COG3134	Outer membrane lipoprotein
C4J83_RS25050	COG1862	Preprotein translocase
C4J83_RS25055	COG0343	queuine tRNA-ribosyltransferase activity
C4J83_RS25060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4J83_RS25075	COG1280	lysine exporter protein (LysE YggA)
C4J83_RS25100	COG0642	Histidine kinase
C4J83_RS25150	COG4251	negative regulation of phosphorylation
C4J83_RS25170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS25175	COG0583	DNA-binding transcription factor activity
C4J83_RS25180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J83_RS25200	COG1104	cysteine desulfurase activity
C4J83_RS25215	COG0506	proline dehydrogenase activity
C4J83_RS25230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J83_RS25235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4J83_RS25240	COG0109	protoheme IX farnesyltransferase activity
C4J83_RS25255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J83_RS25260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J83_RS25270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J83_RS25275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J83_RS25275	COG1017	nitric oxide dioxygenase activity
C4J83_RS25280	COG3604	Transcriptional regulator
C4J83_RS25290	COG3708	Transcriptional regulator
C4J83_RS25290	COG2207	Transcriptional regulator
C4J83_RS25295	COG2197	response regulator
C4J83_RS25310	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS25320	COG0596	Alpha beta hydrolase
C4J83_RS25330	COG1346	cytolysis
C4J83_RS25340	COG0583	DNA-binding transcription factor activity
C4J83_RS25350	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J83_RS25375	COG0302	gtp cyclohydrolase
C4J83_RS25380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J83_RS25395	COG0492	ferredoxin-NADP+ reductase activity
C4J83_RS25405	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4J83_RS25420	COG0386	Belongs to the glutathione peroxidase family
C4J83_RS25425	COG3045	CreA protein
C4J83_RS25430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4J83_RS25435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4J83_RS25440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4J83_RS25445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4J83_RS25450	COG0142	geranyltranstransferase activity
C4J83_RS25455	COG2824	Alkylphosphonate utilization operon protein PhnA
C4J83_RS25460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J83_RS25465	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J83_RS25470	COG0840	transmembrane signaling receptor activity
C4J83_RS25480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4J83_RS25490	COG2610	gluconate transmembrane transporter activity
C4J83_RS25500	COG0659	secondary active sulfate transmembrane transporter activity
C4J83_RS25510	COG0583	DNA-binding transcription factor activity
C4J83_RS25515	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J83_RS25525	COG0583	DNA-binding transcription factor activity
C4J83_RS25530	COG1113	amino acid transport
C4J83_RS25540	COG1522	sequence-specific DNA binding
C4J83_RS25550	COG3485	protocatechuate 3,4-dioxygenase
C4J83_RS25555	COG4829	muconolactone delta-isomerase
C4J83_RS25560	COG4948	Mandelate Racemase Muconate Lactonizing
C4J83_RS25575	COG4638	Rieske (2fe-2S)
C4J83_RS25580	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4J83_RS25585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J83_RS25585	COG0543	2 iron, 2 sulfur cluster binding
C4J83_RS25590	COG1113	amino acid transport
C4J83_RS25595	COG3483	tryptophan 2,3-dioxygenase activity
C4J83_RS25600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4J83_RS25650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J83_RS25655	COG1074	ATP-dependent DNA helicase activity
C4J83_RS25660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4J83_RS25695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4J83_RS25700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J83_RS25705	COG1183	phosphatidylcholine synthase activity
C4J83_RS25710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4J83_RS25720	COG0028	Belongs to the TPP enzyme family
C4J83_RS25725	COG3098	single-species biofilm formation
C4J83_RS25735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J83_RS25755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J83_RS25760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J83_RS25765	COG4558	Periplasmic binding protein
C4J83_RS25775	COG1489	DNA binding
C4J83_RS25780	COG0436	Aminotransferase
C4J83_RS25790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J83_RS25800	COG4191	Histidine kinase
C4J83_RS25820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J83_RS25825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4J83_RS25830	COG0166	Belongs to the GPI family
C4J83_RS25835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J83_RS25845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J83_RS25855	COG2823	Periplasmic or secreted lipoprotein
C4J83_RS25860	COG1185	polyribonucleotide nucleotidyltransferase activity
C4J83_RS25865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4J83_RS25870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4J83_RS25875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4J83_RS25880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4J83_RS25885	COG0195	Participates in both transcription termination and antitermination
C4J83_RS25890	COG0779	Required for maturation of 30S ribosomal subunits
C4J83_RS25905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J83_RS25910	COG0149	triose-phosphate isomerase activity
C4J83_RS25915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J83_RS25920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J83_RS25930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4J83_RS25945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J83_RS25950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4J83_RS25955	COG0505	Belongs to the CarA family
C4J83_RS25960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4J83_RS25965	COG0484	heat shock protein binding
C4J83_RS25970	COG0443	Heat shock 70 kDa protein
C4J83_RS25975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4J83_RS25980	COG0497	DNA recombination
C4J83_RS25985	COG0735	belongs to the Fur family
C4J83_RS25990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J83_RS25995	COG2914	Belongs to the UPF0125 (RnfH) family
C4J83_RS26005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4J83_RS26010	COG2186	Transcriptional regulator
C4J83_RS26015	COG1620	l-lactate permease
C4J83_RS26045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J83_RS26050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J83_RS26050	COG0473	3-isopropylmalate dehydrogenase activity
C4J83_RS26070	COG2862	Uncharacterized protein family, UPF0114
C4J83_RS26085	COG1067	ATP-dependent peptidase activity
C4J83_RS26110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J83_RS26120	COG0488	(ABC) transporter
C4J83_RS26130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J83_RS26135	COG0523	cobalamin synthesis protein
C4J83_RS26140	COG2879	small protein
C4J83_RS26145	COG1966	Carbon starvation protein
C4J83_RS26175	COG1970	mechanosensitive ion channel activity
C4J83_RS26185	COG2197	response regulator
C4J83_RS26190	COG2813	Specifically methylates the guanine in position
C4J83_RS26200	COG1294	oxidase, subunit
C4J83_RS26205	COG1271	oxidase subunit
C4J83_RS26215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J83_RS26220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4J83_RS26225	COG2080	2 iron, 2 sulfur cluster binding
C4J83_RS26235	COG2252	PERMEase
C4J83_RS26240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J83_RS26245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J83_RS26250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J83_RS26255	COG1309	transcriptional regulator
C4J83_RS26260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4J83_RS26260	COG1082	Xylose isomerase domain protein TIM barrel
C4J83_RS26265	COG0477	Major facilitator Superfamily
C4J83_RS26280	COG2321	neutral zinc metallopeptidase
C4J83_RS26300	COG1946	Acyl-CoA thioesterase
C4J83_RS26310	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4J83_RS26320	COG0513	Belongs to the DEAD box helicase family
C4J83_RS26325	COG0697	spore germination
C4J83_RS26330	COG1522	sequence-specific DNA binding
C4J83_RS26350	COG1199	ATP-dependent helicase activity
C4J83_RS26350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J83_RS26360	COG3416	Protein conserved in bacteria
C4J83_RS26375	COG1643	Atp-dependent helicase
C4J83_RS26390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4J83_RS26400	COG1522	sequence-specific DNA binding
C4J83_RS26415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J83_RS26420	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS26435	COG0352	thiamine-phosphate diphosphorylase activity
C4J83_RS26440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J83_RS26455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J83_RS26460	COG1702	phosphate starvation-inducible protein PhoH
C4J83_RS26465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4J83_RS26470	COG4535	Mg2 and Co2 transporter CorC
C4J83_RS26475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4J83_RS26490	COG0495	leucyl-tRNA aminoacylation
C4J83_RS26500	COG1466	dna polymerase III delta subunit
C4J83_RS26510	COG2951	lytic endotransglycosylase activity
C4J83_RS26520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4J83_RS26525	COG0321	lipoyl(octanoyl) transferase activity
C4J83_RS26530	COG2921	Belongs to the UPF0250 family
C4J83_RS26535	COG1686	Belongs to the peptidase S11 family
C4J83_RS26545	COG2951	lytic endotransglycosylase activity
C4J83_RS26550	COG0772	Belongs to the SEDS family
C4J83_RS26555	COG0768	penicillin binding
C4J83_RS26560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4J83_RS26570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4J83_RS26575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4J83_RS26580	COG2094	Belongs to the DNA glycosylase MPG family
C4J83_RS26585	COG0586	Pfam SNARE associated Golgi protein
C4J83_RS26595	COG1346	cytolysis
C4J83_RS26615	COG0702	epimerase
C4J83_RS26630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J83_RS26645	COG3284	Transcriptional regulator
C4J83_RS26655	COG0531	amino acid
C4J83_RS26660	COG4303	Ethanolamine ammonia lyase large subunit
C4J83_RS26665	COG4302	ethanolamine ammonia-lyase activity
C4J83_RS26670	COG0456	acetyltransferase
C4J83_RS26675	COG0586	Pfam SNARE associated Golgi protein
C4J83_RS26680	COG3228	Belongs to the MtfA family
C4J83_RS26685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4J83_RS26735	COG1335	isochorismatase
C4J83_RS26740	COG0754	glutathionylspermidine amidase activity
C4J83_RS26750	COG3766	membrane
C4J83_RS26765	COG1842	Phage shock protein A
C4J83_RS26780	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J83_RS26835	COG1722	exodeoxyribonuclease VII activity
C4J83_RS26840	COG0142	geranyltranstransferase activity
C4J83_RS26845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J83_RS26855	COG4206	TonB-dependent receptor
C4J83_RS26865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J83_RS26875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J83_RS26885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4J83_RS26890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4J83_RS26895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J83_RS26910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J83_RS26910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J83_RS26925	COG2264	protein methyltransferase activity
C4J83_RS26930	COG3118	belongs to the thioredoxin family
C4J83_RS26970	COG1201	RNA secondary structure unwinding
C4J83_RS26975	COG0668	transmembrane transport
C4J83_RS26980	COG2814	Major facilitator Superfamily
C4J83_RS26990	COG3568	Endonuclease Exonuclease Phosphatase
C4J83_RS26995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J83_RS27000	COG0392	lysyltransferase activity
C4J83_RS27015	COG1335	isochorismatase
C4J83_RS27020	COG4106	trans-aconitate 2-methyltransferase activity
C4J83_RS27025	COG0583	DNA-binding transcription factor activity
C4J83_RS27030	COG0629	single-stranded DNA binding
C4J83_RS27035	COG2814	Major facilitator Superfamily
C4J83_RS27040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J83_RS27045	COG2193	ferroxidase activity
C4J83_RS27055	COG0203	ribosomal protein L17
C4J83_RS27060	COG0202	RNA polymerase activity
C4J83_RS27065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4J83_RS27070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4J83_RS27075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4J83_RS27080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4J83_RS27090	COG0200	Binds to the 23S rRNA
C4J83_RS27095	COG1841	ribosomal large subunit assembly
C4J83_RS27100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4J83_RS27105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4J83_RS27110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4J83_RS27115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4J83_RS27120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J83_RS27125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4J83_RS27130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4J83_RS27135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4J83_RS27140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4J83_RS27145	COG0255	Belongs to the universal ribosomal protein uL29 family
C4J83_RS27150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4J83_RS27155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4J83_RS27160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4J83_RS27165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4J83_RS27170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4J83_RS27175	COG0089	rRNA binding
C4J83_RS27180	COG0088	Forms part of the polypeptide exit tunnel
C4J83_RS27185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4J83_RS27190	COG0051	transcription antitermination factor activity, RNA binding
C4J83_RS27195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J83_RS27200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J83_RS27205	COG0049	tRNA binding
C4J83_RS27210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4J83_RS27215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4J83_RS27220	COG0085	RNA polymerase activity
C4J83_RS27225	COG0222	ribosome binding
C4J83_RS27230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4J83_RS27235	COG0081	regulation of translation
C4J83_RS27240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4J83_RS27280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4J83_RS27320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4J83_RS27325	COG0739	heme binding
C4J83_RS27330	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4J83_RS27335	COG0316	Belongs to the HesB IscA family
C4J83_RS27340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4J83_RS27345	COG1981	membrane
C4J83_RS27360	COG4221	oxidoreductase activity
C4J83_RS27365	COG0537	adenosine 5'-monophosphoramidase activity
C4J83_RS27370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4J83_RS27375	COG1765	OsmC-like protein
C4J83_RS27390	COG0134	indole-3-glycerol-phosphate synthase activity
C4J83_RS27395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J83_RS27400	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J83_RS27405	COG4625	pathogenesis
C4J83_RS27405	COG3240	lipase activity
C4J83_RS27410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J83_RS27415	COG0546	phosphoglycolate phosphatase activity
C4J83_RS27420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4J83_RS27425	COG1454	alcohol dehydrogenase
C4J83_RS27435	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J83_RS27445	COG3842	ATPase activity
C4J83_RS27450	COG2197	response regulator
C4J83_RS27465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J83_RS27470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4J83_RS27475	COG3178	'Phosphotransferase
C4J83_RS27480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4J83_RS27485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J83_RS27490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4J83_RS27495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J83_RS27500	COG2967	ApaG domain
C4J83_RS27505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J83_RS27510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J83_RS27515	COG2766	serine protein kinase
C4J83_RS27520	COG2718	Belongs to the UPF0229 family
C4J83_RS27525	COG2719	SpoVR family
C4J83_RS27530	COG0617	tRNA 3'-terminal CCA addition
C4J83_RS27540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J83_RS27545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4J83_RS27550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4J83_RS27555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4J83_RS27560	COG0358	DNA primase activity
C4J83_RS27565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J83_RS27595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J83_RS27600	COG1025	Belongs to the peptidase M16 family
C4J83_RS27610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J83_RS27615	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4J83_RS27625	COG0535	radical SAM domain protein
C4J83_RS27635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J83_RS27640	COG0583	DNA-binding transcription factor activity
C4J83_RS27645	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS27650	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS27665	COG1960	acyl-CoA dehydrogenase activity
C4J83_RS27685	COG1073	alpha beta
C4J83_RS27685	COG2226	methyltransferase
C4J83_RS27690	COG0156	8-amino-7-oxononanoate synthase activity
C4J83_RS27695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4J83_RS27705	COG2005	Transcriptional regulator
C4J83_RS27705	COG3585	molybdate ion transport
C4J83_RS27715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4J83_RS27730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4J83_RS27740	COG4566	intracellular signal transduction
C4J83_RS27740	COG0745	RESPONSE REGULATOR receiver
C4J83_RS27750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J83_RS27755	COG1595	DNA-templated transcription, initiation
C4J83_RS27765	COG0604	alcohol dehydrogenase
C4J83_RS27765	COG3321	synthase
C4J83_RS27765	COG1028	Short-chain dehydrogenase reductase Sdr
C4J83_RS27770	COG4774	siderophore transport
C4J83_RS27785	COG0625	glutathione transferase activity
C4J83_RS27790	COG4452	Inner membrane protein CreD
C4J83_RS27795	COG2205	protein histidine kinase activity
C4J83_RS27800	COG0745	RESPONSE REGULATOR receiver
C4J83_RS27805	COG4067	protein conserved in archaea
C4J83_RS27805	COG0189	ligase activity
C4J83_RS27810	COG0204	Acyl-transferase
C4J83_RS27820	COG1595	DNA-templated transcription, initiation
C4J83_RS27830	COG1063	alcohol dehydrogenase
C4J83_RS27860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J83_RS27890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J83_RS27890	COG1017	nitric oxide dioxygenase activity
C4J83_RS27900	COG4638	Rieske (2fe-2S)
C4J83_RS27915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4J83_RS27920	COG0247	lactate metabolic process
C4J83_RS27920	COG2181	nitrate reductase activity
C4J83_RS27925	COG1902	pentaerythritol trinitrate reductase activity
C4J83_RS27925	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J83_RS27970	COG3246	L-lysine catabolic process to acetate
C4J83_RS27975	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J83_RS28000	COG1760	l-serine dehydratase
C4J83_RS28015	COG4175	Glycine betaine
C4J83_RS28020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J83_RS28025	COG1309	transcriptional regulator
C4J83_RS28030	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS28035	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J83_RS28055	COG0477	Major facilitator Superfamily
C4J83_RS28060	COG0513	Belongs to the DEAD box helicase family
C4J83_RS28065	COG2081	HI0933 family
C4J83_RS28070	COG1289	transmembrane transporter activity
C4J83_RS28080	COG2153	protein acetylation
C4J83_RS28090	COG1451	nucleotide metabolic process
C4J83_RS28120	COG0126	phosphoglycerate kinase activity
C4J83_RS28125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4J83_RS28130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4J83_RS28135	COG0640	Transcriptional regulator
C4J83_RS28140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4J83_RS28150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J83_RS28155	COG1422	Protein of unknown function (DUF1090)
C4J83_RS28190	COG2116	formate transmembrane transporter activity
C4J83_RS28200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4J83_RS28205	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4J83_RS28215	COG0513	Belongs to the DEAD box helicase family
C4J83_RS28220	COG2353	YceI-like domain
C4J83_RS28225	COG3038	cytochrome b561
C4J83_RS28235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4J83_RS28240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS28255	COG1272	protein, Hemolysin III
C4J83_RS28285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4J83_RS28305	COG3052	prosthetic group binding
C4J83_RS28310	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4J83_RS28350	COG2198	Histidine kinase
C4J83_RS28350	COG0784	Response regulator, receiver
C4J83_RS28350	COG0643	Histidine kinase
C4J83_RS28380	COG0189	ligase activity
C4J83_RS28395	COG1678	Uncharacterized ACR, COG1678
C4J83_RS28400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4J83_RS28405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4J83_RS28410	COG0540	Belongs to the ATCase OTCase family
C4J83_RS28415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J83_RS28425	COG0791	NLP P60 protein
C4J83_RS28450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J83_RS28455	COG2813	Specifically methylates the guanine in position
C4J83_RS28455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J83_RS28465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4J83_RS28470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4J83_RS28480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4J83_RS28485	COG2022	thiamine diphosphate biosynthetic process
C4J83_RS28495	COG2363	Small membrane protein
C4J83_RS28500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J83_RS28510	COG2177	Part of the ABC transporter FtsEX involved in
C4J83_RS28515	COG2884	Cell division ATP-binding protein ftsE
C4J83_RS28520	COG0552	protein localization to endoplasmic reticulum
C4J83_RS28525	COG0612	Peptidase, M16
C4J83_RS28530	COG0612	Peptidase, M16
C4J83_RS28535	COG0742	ribosomal rna small subunit methyltransferase
C4J83_RS28540	COG0429	hydrolase of the alpha beta-hydrolase fold
C4J83_RS28550	COG1309	transcriptional regulator
C4J83_RS28565	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J83_RS28570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4J83_RS28575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J83_RS28580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J83_RS28590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J83_RS28600	COG2814	Major facilitator Superfamily
C4J83_RS28605	COG0129	dihydroxy-acid dehydratase activity
C4J83_RS28620	COG1823	symporter activity
C4J83_RS28635	COG1160	GTP binding
C4J83_RS28650	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J83_RS28655	COG1178	ABC-type Fe3 transport system permease component
C4J83_RS28660	COG3842	ATPase activity
C4J83_RS28665	COG0583	DNA-binding transcription factor activity
C4J83_RS28675	COG0789	Transcriptional regulator
C4J83_RS28680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4J83_RS28685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4J83_RS28700	COG0494	nUDIX hydrolase
C4J83_RS28715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J83_RS28720	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4J83_RS28725	COG2234	aminopeptidase activity
C4J83_RS28730	COG3204	pilus organization
C4J83_RS28735	COG3204	pilus organization
C4J83_RS28740	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J83_RS28745	COG0277	FAD linked oxidase domain protein
C4J83_RS28755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J83_RS28765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS28770	COG1683	Conserved Protein
C4J83_RS28835	COG1917	Cupin 2, conserved barrel domain protein
C4J83_RS28835	COG4977	sequence-specific DNA binding
C4J83_RS28840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J83_RS28855	COG1177	transmembrane transport
C4J83_RS28860	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J83_RS28865	COG3842	ATPase activity
C4J83_RS28885	COG0174	glutamine synthetase
C4J83_RS28890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4J83_RS28895	COG0174	glutamine synthetase
C4J83_RS28910	COG1116	anion transmembrane transporter activity
C4J83_RS28915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J83_RS28920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J83_RS28925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J83_RS28930	COG0431	NADPH-dependent FMN reductase
C4J83_RS28935	COG0450	alkyl hydroperoxide reductase
C4J83_RS28945	COG4521	taurine ABC transporter
C4J83_RS28950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4J83_RS28950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J83_RS28970	COG1522	sequence-specific DNA binding
C4J83_RS28980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J83_RS28985	COG0330	HflC and HflK could
C4J83_RS29005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J83_RS29015	COG0509	glycine decarboxylation via glycine cleavage system
C4J83_RS29020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J83_RS29025	COG1178	ABC-type Fe3 transport system permease component
C4J83_RS29035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J83_RS29045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J83_RS29050	COG0006	proline dipeptidase activity
C4J83_RS29055	COG3079	Belongs to the UPF0149 family
C4J83_RS29075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4J83_RS29085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J83_RS29090	COG0842	Transport permease protein
C4J83_RS29090	COG1129	ABC transporter
C4J83_RS29095	COG0842	Transport permease protein
C4J83_RS29110	COG2271	Major facilitator Superfamily
C4J83_RS29135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4J83_RS29155	COG2186	Transcriptional regulator
C4J83_RS29160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J83_RS29165	COG0765	amino acid transport
C4J83_RS29170	COG0765	amino acid transport
C4J83_RS29175	COG1126	abc transporter atp-binding protein
C4J83_RS29185	COG3188	usher protein
C4J83_RS29190	COG3121	Chaperone
C4J83_RS29200	COG0248	Ppx GppA phosphatase
C4J83_RS29205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4J83_RS29215	COG0586	Pfam SNARE associated Golgi protein
C4J83_RS29225	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4J83_RS29230	COG1671	Belongs to the UPF0178 family
C4J83_RS29235	COG0672	)-iron permease
C4J83_RS29265	COG1280	lysine exporter protein (LysE YggA)
C4J83_RS29275	COG0488	(ABC) transporter
C4J83_RS29300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J83_RS29320	COG0181	hydroxymethylbilane synthase activity
C4J83_RS29330	COG0165	Argininosuccinate lyase
C4J83_RS29335	COG0625	glutathione transferase activity
C4J83_RS29355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J83_RS29365	COG1965	Belongs to the frataxin family
C4J83_RS29375	COG0019	diaminopimelate decarboxylase activity
C4J83_RS29380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J83_RS29390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J83_RS29395	COG1011	Hydrolase
C4J83_RS29405	COG0432	Pfam Uncharacterised protein family UPF0047
C4J83_RS29410	COG0004	ammonium transporteR
C4J83_RS29415	COG0347	Belongs to the P(II) protein family
C4J83_RS29425	COG0606	chelatase, subunit chli
C4J83_RS29440	COG0840	transmembrane signaling receptor activity
C4J83_RS29445	COG0583	DNA-binding transcription factor activity
C4J83_RS29450	COG0534	Mate efflux family protein
C4J83_RS29465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J83_RS29470	COG0427	acetyl-CoA hydrolase
C4J83_RS29485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4J83_RS29495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS29510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J83_RS29520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J83_RS29525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J83_RS29540	COG1012	belongs to the aldehyde dehydrogenase family
C4J83_RS29550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J83_RS29555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J83_RS29560	COG0747	negative chemotaxis
C4J83_RS29565	COG2003	Belongs to the UPF0758 family
C4J83_RS29570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4J83_RS29575	COG0756	dUTP diphosphatase activity
C4J83_RS29585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J83_RS29590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J83_RS29595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4J83_RS29600	COG0708	Exodeoxyribonuclease III
C4J83_RS29610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4J83_RS29615	COG1561	YicC-like family, N-terminal region
C4J83_RS29620	COG0194	GDP metabolic process
C4J83_RS29625	COG1758	RNA polymerase activity
C4J83_RS29630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J83_RS29660	COG0848	biopolymer transport protein
C4J83_RS29670	COG0583	DNA-binding transcription factor activity
C4J83_RS29675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4J83_RS29705	COG1136	(ABC) transporter
C4J83_RS29710	COG2815	serine threonine protein kinase
C4J83_RS29710	COG0515	serine threonine protein kinase
C4J83_RS29715	COG0631	protein serine/threonine phosphatase activity
C4J83_RS29820	COG3209	COG3209 Rhs family protein
C4J83_RS29855	COG3161	chorismate lyase activity
C4J83_RS29860	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4J83_RS29880	COG1253	flavin adenine dinucleotide binding
C4J83_RS29890	COG0704	Plays a role in the regulation of phosphate uptake
C4J83_RS29895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J83_RS29900	COG0573	inorganic phosphate transmembrane transporter activity
C4J83_RS29915	COG0477	Major facilitator Superfamily
C4J83_RS29920	COG1607	acyl-coa hydrolase
C4J83_RS29925	COG0676	glucose-6-phosphate 1-epimerase activity
C4J83_RS29950	COG0583	DNA-binding transcription factor activity
C4J83_RS29955	COG1027	Aspartate ammonia-lyase
C4J83_RS29960	COG1115	amino acid carrier protein
C4J83_RS29965	COG0252	asparaginase activity
C4J83_RS29995	COG2808	Putative FMN-binding domain
C4J83_RS30020	COG0511	ligase activity, forming carbon-carbon bonds
C4J83_RS30020	COG5016	pyruvate
C4J83_RS30025	COG0439	Biotin carboxylase
C4J83_RS30030	COG0583	DNA-binding transcription factor activity
C4J83_RS30045	COG5001	Diguanylate cyclase
C4J83_RS30045	COG3300	MHYT domain
C4J83_RS30065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J83_RS30065	COG4651	solute:proton antiporter activity
C4J83_RS30070	COG1607	acyl-coa hydrolase
C4J83_RS30075	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4J83_RS30085	COG0523	cobalamin synthesis protein
C4J83_RS30110	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J83_RS30115	COG1469	GTP cyclohydrolase I activity
C4J83_RS30120	COG1121	(ABC) transporter
C4J83_RS30135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J83_RS30145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J83_RS30155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J83_RS30160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J83_RS30200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4J83_RS30205	COG2267	carboxylic ester hydrolase activity
C4J83_RS30210	COG2453	phosphatase
C4J83_RS30210	COG0671	phosphoesterase, PA-phosphatase related
C4J83_RS30225	COG4589	Belongs to the CDS family
C4J83_RS30230	COG1522	sequence-specific DNA binding
C4J83_RS30235	COG1280	lysine exporter protein (LysE YggA)
C4J83_RS30240	COG2373	Large extracellular alpha-helical protein
C4J83_RS30245	COG4953	penicillin-binding protein 1C
C4J83_RS30260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J83_RS30270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J83_RS30275	COG1349	DNA-binding transcription factor activity
C4J83_RS30280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J83_RS30285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4J83_RS30290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4J83_RS30295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4J83_RS30300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4J83_RS30305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J83_RS30310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4J83_RS30320	COG0356	it plays a direct role in the translocation of protons across the membrane
C4J83_RS30325	COG3312	ion transport
C4J83_RS30330	COG1475	DNA binding
C4J83_RS30335	COG1192	Involved in chromosome partitioning
C4J83_RS30340	COG0357	Ribosomal RNA small subunit methyltransferase G
C4J83_RS30345	COG0445	tRNA wobble uridine modification
C4J83_RS30350	COG1595	DNA-templated transcription, initiation
C4J83_RS30355	COG3712	iron ion homeostasis
C4J83_RS30360	COG4774	siderophore transport
C4J83_RS30365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4J83_RS30370	COG0706	membrane insertase activity
C4J83_RS30375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4J83_RS30380	COG0594	ribonuclease P activity
C4J83_RS30385	COG0230	Belongs to the bacterial ribosomal protein bL34 family