locus-tag	class	description
C5F71_RS00180	COG0582	viral genome integration into host DNA
C5F71_RS00195	COG0322	excinuclease ABC activity
C5F71_RS00200	COG2197	response regulator
C5F71_RS00225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5F71_RS00230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F71_RS00235	COG4166	transmembrane transport
C5F71_RS00240	COG4174	ABC transporter (Permease)
C5F71_RS00245	COG4239	(ABC) transporter, permease
C5F71_RS00250	COG4172	Belongs to the ABC transporter superfamily
C5F71_RS00255	COG3290	protein histidine kinase activity
C5F71_RS00255	COG3829	transcription factor binding
C5F71_RS00260	COG2610	gluconate transmembrane transporter activity
C5F71_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS00270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F71_RS00280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F71_RS00285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F71_RS00310	COG3118	belongs to the thioredoxin family
C5F71_RS00315	COG1253	flavin adenine dinucleotide binding
C5F71_RS00330	COG0698	ribose 5-phosphate isomerase
C5F71_RS00335	COG1129	ABC transporter
C5F71_RS00340	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F71_RS00345	COG1879	ABC-type sugar transport system periplasmic component
C5F71_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS00355	COG1063	alcohol dehydrogenase
C5F71_RS00360	COG2376	Dihydroxyacetone kinase
C5F71_RS00370	COG0583	DNA-binding transcription factor activity
C5F71_RS00375	COG0477	Major facilitator Superfamily
C5F71_RS00385	COG0616	signal peptide processing
C5F71_RS00400	COG5383	Protein conserved in bacteria
C5F71_RS00415	COG0784	Response regulator, receiver
C5F71_RS00415	COG4191	Histidine kinase
C5F71_RS00420	COG0587	DNA-directed DNA polymerase activity
C5F71_RS00435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5F71_RS00445	COG0673	inositol 2-dehydrogenase activity
C5F71_RS00460	COG2203	Gaf domain
C5F71_RS00460	COG3706	GGDEF domain
C5F71_RS00460	COG4251	negative regulation of phosphorylation
C5F71_RS00460	COG5001	Diguanylate cyclase
C5F71_RS00480	COG4774	siderophore transport
C5F71_RS00490	COG1595	DNA-templated transcription, initiation
C5F71_RS00530	COG3121	Chaperone
C5F71_RS00540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS00540	COG2205	protein histidine kinase activity
C5F71_RS00545	COG2205	protein histidine kinase activity
C5F71_RS00545	COG0784	Response regulator, receiver
C5F71_RS00550	COG2197	response regulator
C5F71_RS00560	COG3706	GGDEF domain
C5F71_RS00560	COG2203	Gaf domain
C5F71_RS00560	COG5001	Diguanylate cyclase
C5F71_RS00560	COG4251	negative regulation of phosphorylation
C5F71_RS00590	COG0322	excinuclease ABC activity
C5F71_RS00640	COG2199	diguanylate cyclase activity
C5F71_RS00670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5F71_RS00680	COG2175	clavaminate synthase activity
C5F71_RS00685	COG0583	DNA-binding transcription factor activity
C5F71_RS00705	COG0477	Major facilitator Superfamily
C5F71_RS00710	COG2197	response regulator
C5F71_RS00755	COG2168	tRNA wobble position uridine thiolation
C5F71_RS00765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5F71_RS00770	COG0435	Glutathione S-transferase
C5F71_RS00775	COG1648	precorrin-2 dehydrogenase activity
C5F71_RS00775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5F71_RS00780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5F71_RS00785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5F71_RS00790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5F71_RS00795	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5F71_RS00800	COG1674	ftsk spoiiie
C5F71_RS00805	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C5F71_RS00810	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C5F71_RS00815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5F71_RS00820	COG0542	response to heat
C5F71_RS00825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5F71_RS00830	COG1278	Cold shock
C5F71_RS00845	COG0583	DNA-binding transcription factor activity
C5F71_RS00860	COG0482	sulfurtransferase activity
C5F71_RS00865	COG2915	High frequency lysogenization protein hflD homolog
C5F71_RS00875	COG2850	peptidyl-arginine hydroxylation
C5F71_RS00880	COG2153	protein acetylation
C5F71_RS00895	COG2224	Isocitrate lyase
C5F71_RS00900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F71_RS00905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F71_RS00910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F71_RS00910	COG0649	NAD binding
C5F71_RS00925	COG1034	ATP synthesis coupled electron transport
C5F71_RS00930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5F71_RS00935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F71_RS00945	COG0713	ATP synthesis coupled electron transport
C5F71_RS00960	COG1007	ATP synthesis coupled electron transport
C5F71_RS00965	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C5F71_RS00970	COG2944	sequence-specific DNA binding
C5F71_RS00985	COG0395	ABC-type sugar transport system, permease component
C5F71_RS00995	COG3842	ATPase activity
C5F71_RS01000	COG3842	ATPase activity
C5F71_RS01005	COG3284	Transcriptional regulator
C5F71_RS01010	COG3209	COG3209 Rhs family protein
C5F71_RS01010	COG3209	COG3209 Rhs family protein
C5F71_RS01025	COG0215	cysteine-tRNA ligase activity
C5F71_RS01030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5F71_RS01040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F71_RS01045	COG2814	Major facilitator Superfamily
C5F71_RS01050	COG1566	PFAM secretion protein HlyD family protein
C5F71_RS01055	COG1846	Transcriptional regulator
C5F71_RS01060	COG2911	Protein conserved in bacteria
C5F71_RS01065	COG0729	surface antigen
C5F71_RS01075	COG0708	Exodeoxyribonuclease III
C5F71_RS01080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5F71_RS01085	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS01095	COG0789	Transcriptional regulator
C5F71_RS01105	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS01110	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS01115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5F71_RS01145	COG2866	Carboxypeptidase
C5F71_RS01155	COG2814	Major facilitator Superfamily
C5F71_RS01160	COG3038	cytochrome b561
C5F71_RS01190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5F71_RS01200	COG0217	transcriptional regulatory protein
C5F71_RS01215	COG0583	DNA-binding transcription factor activity
C5F71_RS01220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5F71_RS01225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5F71_RS01230	COG3038	cytochrome b561
C5F71_RS01240	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5F71_RS01240	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS01260	COG0583	DNA-binding transcription factor activity
C5F71_RS01270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F71_RS01275	COG0776	regulation of translation
C5F71_RS01280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5F71_RS01285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5F71_RS01290	COG0740	serine-type endopeptidase activity
C5F71_RS01295	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5F71_RS01320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5F71_RS01325	COG1686	Belongs to the peptidase S11 family
C5F71_RS01345	COG1953	Uracil, thiamine, allantoin
C5F71_RS01355	COG0493	'glutamate synthase
C5F71_RS01365	COG1309	transcriptional regulator
C5F71_RS01395	COG0471	metal ion transport
C5F71_RS01400	COG0642	Histidine kinase
C5F71_RS01425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5F71_RS01475	COG0784	Response regulator, receiver
C5F71_RS01475	COG2205	protein histidine kinase activity
C5F71_RS01495	COG0730	response to heat
C5F71_RS01510	COG1522	sequence-specific DNA binding
C5F71_RS01515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5F71_RS01520	COG0022	dehydrogenase e1 component
C5F71_RS01530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5F71_RS01535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5F71_RS01540	COG0456	acetyltransferase
C5F71_RS01555	COG2423	ornithine cyclodeaminase activity
C5F71_RS01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS01565	COG4215	(ABC) transporter
C5F71_RS01575	COG4598	ABC transporter
C5F71_RS01635	COG2814	Major facilitator Superfamily
C5F71_RS01655	COG0174	glutamine synthetase
C5F71_RS01665	COG4335	DNA alkylation repair
C5F71_RS01690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5F71_RS01695	COG0517	IMP dehydrogenase activity
C5F71_RS01705	COG0583	DNA-binding transcription factor activity
C5F71_RS01710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5F71_RS01740	COG0113	porphobilinogen synthase activity
C5F71_RS01745	COG0384	phenazine biosynthesis protein PhzF
C5F71_RS01750	COG0625	glutathione transferase activity
C5F71_RS01760	COG0701	Predicted permease
C5F71_RS01765	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C5F71_RS01770	COG0709	Synthesizes selenophosphate from selenide and ATP
C5F71_RS01775	COG1253	flavin adenine dinucleotide binding
C5F71_RS01785	COG0583	DNA-binding transcription factor activity
C5F71_RS01795	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5F71_RS01810	COG3132	Protein of unknown function, DUF480
C5F71_RS01815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5F71_RS01835	COG0628	permease
C5F71_RS01840	COG0826	peptidase U32
C5F71_RS01850	COG2056	Na+-H+ antiporter family
C5F71_RS01855	COG0840	transmembrane signaling receptor activity
C5F71_RS01870	COG2358	TRAP transporter, solute receptor (TAXI family
C5F71_RS01905	COG3655	Transcriptional regulator
C5F71_RS01920	COG0582	viral genome integration into host DNA
C5F71_RS01930	COG3179	chitinase
C5F71_RS01945	COG5410	chromosome segregation
C5F71_RS01950	COG3728	DNA packaging
C5F71_RS02080	COG2369	cell adhesion
C5F71_RS02085	COG3567	Phage-associated protein, HI1409 family
C5F71_RS02170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5F71_RS02315	COG0720	synthase
C5F71_RS02330	COG1051	belongs to the nudix hydrolase family
C5F71_RS02335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5F71_RS02345	COG0402	S-adenosylhomocysteine deaminase activity
C5F71_RS02350	COG3675	Pfam Lipase (class 3)
C5F71_RS02380	COG2223	nitrite transmembrane transporter activity
C5F71_RS02400	COG4772	TonB-dependent receptor
C5F71_RS02410	COG1595	DNA-templated transcription, initiation
C5F71_RS02415	COG0534	Mate efflux family protein
C5F71_RS02420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS02430	COG0174	glutamine synthetase
C5F71_RS02445	COG0022	dehydrogenase e1 component
C5F71_RS02450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5F71_RS02455	COG3284	Transcriptional regulator
C5F71_RS02470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F71_RS02485	COG0745	RESPONSE REGULATOR receiver
C5F71_RS02490	COG2205	protein histidine kinase activity
C5F71_RS02495	COG4771	TonB-dependent receptor
C5F71_RS02500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS02505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS02510	COG3209	COG3209 Rhs family protein
C5F71_RS02510	COG3209	COG3209 Rhs family protein
C5F71_RS02520	COG3706	GGDEF domain
C5F71_RS02525	COG1280	lysine exporter protein (LysE YggA)
C5F71_RS02535	COG0154	amidase activity
C5F71_RS02555	COG0583	DNA-binding transcription factor activity
C5F71_RS02560	COG2186	Transcriptional regulator
C5F71_RS02610	COG1609	Transcriptional regulator
C5F71_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS02625	COG1063	alcohol dehydrogenase
C5F71_RS02630	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F71_RS02640	COG1879	ABC-type sugar transport system periplasmic component
C5F71_RS02675	COG1522	sequence-specific DNA binding
C5F71_RS02690	COG1846	Transcriptional regulator
C5F71_RS02715	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS02720	COG3384	dioxygenase
C5F71_RS02730	COG2271	Major facilitator Superfamily
C5F71_RS02735	COG3971	2-oxopent-4-enoate hydratase activity
C5F71_RS02745	COG1846	Transcriptional regulator
C5F71_RS02750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS02770	COG0531	amino acid
C5F71_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS02880	COG0776	regulation of translation
C5F71_RS02885	COG0072	phenylalanine-tRNA ligase activity
C5F71_RS02890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5F71_RS02895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5F71_RS02900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5F71_RS02905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5F71_RS02910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5F71_RS02920	COG1278	Cold shock
C5F71_RS02945	COG1869	D-ribose catabolic process
C5F71_RS02950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F71_RS02955	COG1609	Transcriptional regulator
C5F71_RS02960	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F71_RS02965	COG1129	ABC transporter
C5F71_RS02995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5F71_RS03010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5F71_RS03030	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C5F71_RS03050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS03085	COG1286	toxin biosynthetic process
C5F71_RS03095	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5F71_RS03100	COG0285	dihydrofolate synthase activity
C5F71_RS03105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5F71_RS03110	COG0135	phosphoribosylanthranilate isomerase activity
C5F71_RS03135	COG0473	3-isopropylmalate dehydrogenase activity
C5F71_RS03140	COG2226	methyltransferase
C5F71_RS03145	COG0066	3-isopropylmalate dehydratase activity
C5F71_RS03150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5F71_RS03185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5F71_RS03195	COG0596	Alpha beta hydrolase
C5F71_RS03225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5F71_RS03240	COG0556	nucleotide-excision repair
C5F71_RS03255	COG0583	DNA-binding transcription factor activity
C5F71_RS03260	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS03275	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C5F71_RS03305	COG3188	usher protein
C5F71_RS03310	COG3121	Chaperone
C5F71_RS03320	COG2205	protein histidine kinase activity
C5F71_RS03320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS03325	COG2197	response regulator
C5F71_RS03345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5F71_RS03370	COG2258	MOSC domain
C5F71_RS03395	COG2384	SAM-dependent methyltransferase
C5F71_RS03400	COG1538	Outer membrane efflux protein
C5F71_RS03405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS03415	COG0789	Transcriptional regulator
C5F71_RS03425	COG3781	membrane
C5F71_RS03460	COG0251	oxidation-reduction process
C5F71_RS03465	COG3949	Membrane
C5F71_RS03470	COG2957	Belongs to the agmatine deiminase family
C5F71_RS03485	COG2957	Belongs to the agmatine deiminase family
C5F71_RS03490	COG0583	DNA-binding transcription factor activity
C5F71_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS03540	COG1942	4-Oxalocrotonate Tautomerase
C5F71_RS03545	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS03550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F71_RS03570	COG0582	viral genome integration into host DNA
C5F71_RS03595	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS03605	COG2814	Major facilitator Superfamily
C5F71_RS03610	COG2267	carboxylic ester hydrolase activity
C5F71_RS03615	COG2233	PERMEase
C5F71_RS03620	COG0583	DNA-binding transcription factor activity
C5F71_RS03630	COG2814	Major facilitator Superfamily
C5F71_RS03635	COG0583	DNA-binding transcription factor activity
C5F71_RS03640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F71_RS03655	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5F71_RS03660	COG1611	Belongs to the LOG family
C5F71_RS03695	COG0583	DNA-binding transcription factor activity
C5F71_RS03700	COG0579	oxidoreductase
C5F71_RS03730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5F71_RS03735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5F71_RS03755	COG3385	transposase activity
C5F71_RS03760	COG2853	Lipoprotein
C5F71_RS03775	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C5F71_RS03775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C5F71_RS03800	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5F71_RS03805	COG1136	(ABC) transporter
C5F71_RS03810	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5F71_RS03820	COG0584	glycerophosphoryl diester phosphodiesterase
C5F71_RS03825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5F71_RS03830	COG1477	protein flavinylation
C5F71_RS03845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5F71_RS03855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5F71_RS03905	COG0183	Belongs to the thiolase family
C5F71_RS03910	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F71_RS03910	COG1024	Enoyl-CoA hydratase
C5F71_RS03920	COG0589	response to stress
C5F71_RS03925	COG0488	(ABC) transporter
C5F71_RS03930	COG0741	lytic transglycosylase activity
C5F71_RS03935	COG1132	(ABC) transporter
C5F71_RS03940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5F71_RS03950	COG0425	Belongs to the sulfur carrier protein TusA family
C5F71_RS03955	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C5F71_RS03970	COG0840	transmembrane signaling receptor activity
C5F71_RS03980	COG3278	Belongs to the heme-copper respiratory oxidase family
C5F71_RS04000	COG3278	Belongs to the heme-copper respiratory oxidase family
C5F71_RS04015	COG2010	Cytochrome c
C5F71_RS04030	COG0348	domain, Protein
C5F71_RS04065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F71_RS04070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5F71_RS04075	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS04080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5F71_RS04085	COG2130	NADP-dependent
C5F71_RS04090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5F71_RS04095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5F71_RS04110	COG0840	transmembrane signaling receptor activity
C5F71_RS04135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5F71_RS04140	COG3115	cell septum assembly
C5F71_RS04160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5F71_RS04170	COG0402	S-adenosylhomocysteine deaminase activity
C5F71_RS04175	COG1802	Transcriptional regulator
C5F71_RS04180	COG3135	benzoate transporter
C5F71_RS04185	COG3171	Protein conserved in bacteria
C5F71_RS04200	COG0116	Belongs to the methyltransferase superfamily
C5F71_RS04200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5F71_RS04210	COG3130	regulation of translation
C5F71_RS04215	COG0167	dihydroorotate dehydrogenase activity
C5F71_RS04235	COG1116	anion transmembrane transporter activity
C5F71_RS04235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5F71_RS04240	COG3707	response regulator
C5F71_RS04245	COG2223	nitrite transmembrane transporter activity
C5F71_RS04255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5F71_RS04260	COG2146	nitrite reductase [NAD(P)H] activity
C5F71_RS04265	COG0243	molybdopterin cofactor binding
C5F71_RS04270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5F71_RS04275	COG2885	chlorophyll binding
C5F71_RS04275	COG3047	cAMP biosynthetic process
C5F71_RS04300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5F71_RS04315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C5F71_RS04320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS04340	COG1045	serine acetyltransferase
C5F71_RS04345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5F71_RS04350	COG2079	MmgE PrpD family protein
C5F71_RS04365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5F71_RS04370	COG0372	Belongs to the citrate synthase family
C5F71_RS04380	COG1802	Transcriptional regulator
C5F71_RS04385	COG0189	ligase activity
C5F71_RS04385	COG4067	protein conserved in archaea
C5F71_RS04395	COG0189	ligase activity
C5F71_RS04415	COG0560	Phosphoserine phosphatase
C5F71_RS04425	COG1953	Uracil, thiamine, allantoin
C5F71_RS04440	COG0583	DNA-binding transcription factor activity
C5F71_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS04450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5F71_RS04490	COG0598	Magnesium transport protein CorA
C5F71_RS04495	COG0519	Catalyzes the synthesis of GMP from XMP
C5F71_RS04500	COG1024	Enoyl-CoA hydratase
C5F71_RS04500	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F71_RS04505	COG0183	Belongs to the thiolase family
C5F71_RS04525	COG2308	Evidence 4 Homologs of previously reported genes of
C5F71_RS04555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS04560	COG3047	cAMP biosynthetic process
C5F71_RS04560	COG2885	chlorophyll binding
C5F71_RS04590	COG2207	Transcriptional regulator
C5F71_RS04595	COG1064	alcohol dehydrogenase
C5F71_RS04600	COG1414	Transcriptional regulator
C5F71_RS04635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5F71_RS04645	COG0084	hydrolase, TatD family'
C5F71_RS04655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5F71_RS04660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5F71_RS04670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F71_RS04675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5F71_RS04690	COG0416	fatty acid biosynthetic process
C5F71_RS04695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5F71_RS04700	COG1399	metal-binding, possibly nucleic acid-binding protein
C5F71_RS04705	COG0424	maF-like protein
C5F71_RS04710	COG0616	signal peptide processing
C5F71_RS04710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5F71_RS04715	COG0546	phosphoglycolate phosphatase activity
C5F71_RS04730	COG1530	ribonuclease E activity
C5F71_RS04735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5F71_RS04740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5F71_RS04740	COG3608	succinylglutamate desuccinylase aspartoacylase
C5F71_RS04760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5F71_RS04765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5F71_RS04770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5F71_RS04775	COG2835	tetraacyldisaccharide 4'-kinase activity
C5F71_RS04780	COG1663	tetraacyldisaccharide 4'-kinase activity
C5F71_RS04785	COG0848	biopolymer transport protein
C5F71_RS04790	COG0811	peptide transport
C5F71_RS04795	COG2333	competence protein COMEC
C5F71_RS04795	COG0658	competence protein
C5F71_RS04805	COG0784	Response regulator, receiver
C5F71_RS04805	COG2205	protein histidine kinase activity
C5F71_RS04805	COG5002	protein histidine kinase activity
C5F71_RS04810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F71_RS04830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5F71_RS04835	COG1393	Belongs to the ArsC family
C5F71_RS04855	COG0037	tRNA processing
C5F71_RS04865	COG3091	SprT-like family
C5F71_RS04870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F71_RS04875	COG1301	dicarboxylic acid transport
C5F71_RS04880	COG4977	sequence-specific DNA binding
C5F71_RS04880	COG1917	Cupin 2, conserved barrel domain protein
C5F71_RS04900	COG2205	protein histidine kinase activity
C5F71_RS04905	COG0745	RESPONSE REGULATOR receiver
C5F71_RS04930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5F71_RS04935	COG1558	bacterial-type flagellum-dependent cell motility
C5F71_RS04940	COG1815	bacterial-type flagellum-dependent cell motility
C5F71_RS04945	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5F71_RS04950	COG0784	Response regulator, receiver
C5F71_RS04950	COG0835	chemotaxis
C5F71_RS04970	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C5F71_RS04975	COG0477	Major facilitator Superfamily
C5F71_RS05005	COG2239	Acts as a magnesium transporter
C5F71_RS05025	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5F71_RS05030	COG0527	aspartate kinase activity
C5F71_RS05035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5F71_RS05040	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C5F71_RS05045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5F71_RS05050	COG2988	succinylglutamate desuccinylase activity
C5F71_RS05060	COG3724	N-succinylarginine dihydrolase activity
C5F71_RS05065	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS05080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F71_RS05115	COG4215	(ABC) transporter
C5F71_RS05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS05125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F71_RS05135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5F71_RS05175	COG3706	GGDEF domain
C5F71_RS05190	COG0504	CTP synthase activity
C5F71_RS05195	COG2329	Antibiotic biosynthesis monooxygenase
C5F71_RS05205	COG0584	glycerophosphoryl diester phosphodiesterase
C5F71_RS05230	COG0306	phosphate transporter
C5F71_RS05235	COG1984	allophanate hydrolase subunit 2
C5F71_RS05245	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5F71_RS05255	COG0583	DNA-binding transcription factor activity
C5F71_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS05270	COG0583	DNA-binding transcription factor activity
C5F71_RS05275	COG4941	Belongs to the sigma-70 factor family
C5F71_RS05285	COG3795	YCII-related domain
C5F71_RS05315	COG0436	Aminotransferase
C5F71_RS05325	COG3265	gluconokinase activity
C5F71_RS05330	COG1609	Transcriptional regulator
C5F71_RS05360	COG0242	peptide deformylase activity
C5F71_RS05365	COG1295	ribonuclease BN
C5F71_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS05385	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS05390	COG2267	carboxylic ester hydrolase activity
C5F71_RS05395	COG2030	dehydratase
C5F71_RS05410	COG3530	Putative quorum-sensing-regulated virulence factor
C5F71_RS05415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5F71_RS05425	COG0800	Aldolase
C5F71_RS05440	COG1737	Transcriptional regulator
C5F71_RS05445	COG0676	glucose-6-phosphate 1-epimerase activity
C5F71_RS05465	COG0395	ABC-type sugar transport system, permease component
C5F71_RS05470	COG1175	transmembrane transport
C5F71_RS05475	COG1653	transport
C5F71_RS05480	COG2942	2-epimerase
C5F71_RS05490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F71_RS05495	COG0583	DNA-binding transcription factor activity
C5F71_RS05505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5F71_RS05525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5F71_RS05560	COG1113	amino acid transport
C5F71_RS05575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5F71_RS05585	COG0009	L-threonylcarbamoyladenylate synthase
C5F71_RS05595	COG2917	probably involved in intracellular septation
C5F71_RS05600	COG2350	Protein conserved in bacteria
C5F71_RS05610	COG0745	RESPONSE REGULATOR receiver
C5F71_RS05620	COG0642	Histidine kinase
C5F71_RS05625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F71_RS05645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5F71_RS05670	COG0509	glycine decarboxylation via glycine cleavage system
C5F71_RS05675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5F71_RS05675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5F71_RS05680	COG1760	l-serine dehydratase
C5F71_RS05685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F71_RS05690	COG1278	Cold shock
C5F71_RS05700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5F71_RS05705	COG0583	DNA-binding transcription factor activity
C5F71_RS05710	COG1304	FMN binding
C5F71_RS05715	COG5654	RES domain protein
C5F71_RS05735	COG0583	DNA-binding transcription factor activity
C5F71_RS05745	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5F71_RS05750	COG0602	queuosine metabolic process
C5F71_RS05755	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5F71_RS05760	COG2885	chlorophyll binding
C5F71_RS05765	COG0823	Involved in the tonB-independent uptake of proteins
C5F71_RS05785	COG0824	Thioesterase
C5F71_RS05790	COG2255	four-way junction helicase activity
C5F71_RS05795	COG0632	four-way junction helicase activity
C5F71_RS05800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5F71_RS05805	COG0217	transcriptional regulatory protein
C5F71_RS05810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5F71_RS05825	COG0783	Belongs to the Dps family
C5F71_RS05835	COG2900	Belongs to the SlyX family
C5F71_RS05850	COG0668	transmembrane transport
C5F71_RS05855	COG1666	GTP binding
C5F71_RS05865	COG4191	Histidine kinase
C5F71_RS05865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS05870	COG2096	Adenosyltransferase
C5F71_RS05880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5F71_RS05885	COG0653	protein targeting
C5F71_RS05895	COG0433	COG0433 Predicted ATPase
C5F71_RS05910	COG0788	formyltetrahydrofolate deformylase activity
C5F71_RS05920	COG2925	Exonuclease
C5F71_RS05945	COG0714	Associated with various cellular activities
C5F71_RS05965	COG0469	pyruvate kinase activity
C5F71_RS05970	COG1024	Enoyl-CoA hydratase
C5F71_RS05990	COG4191	Histidine kinase
C5F71_RS06000	COG0477	Major facilitator Superfamily
C5F71_RS06025	COG2207	Transcriptional regulator
C5F71_RS06060	COG3712	iron ion homeostasis
C5F71_RS06075	COG2832	Protein of unknown function (DUF454)
C5F71_RS06080	COG0840	transmembrane signaling receptor activity
C5F71_RS06110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS06115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS06125	COG3642	lipopolysaccharide core region biosynthetic process
C5F71_RS06135	COG0642	Histidine kinase
C5F71_RS06145	COG1368	sulfuric ester hydrolase activity
C5F71_RS06150	COG0459	protein refolding
C5F71_RS06155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5F71_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS06180	COG3695	enzyme binding
C5F71_RS06185	COG2211	Major facilitator Superfamily
C5F71_RS06195	COG0442	prolyl-tRNA aminoacylation
C5F71_RS06205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5F71_RS06230	COG3158	transport of potassium into the cell
C5F71_RS06235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5F71_RS06250	COG4807	Protein conserved in bacteria
C5F71_RS06265	COG0583	DNA-binding transcription factor activity
C5F71_RS06280	COG3148	PFAM DTW domain containing protein
C5F71_RS06295	COG2137	regulation of response to DNA damage stimulus
C5F71_RS06300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5F71_RS06305	COG1546	Belongs to the CinA family
C5F71_RS06315	COG3179	chitinase
C5F71_RS06415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5F71_RS06425	COG0489	protein tyrosine kinase activity
C5F71_RS06430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5F71_RS06430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5F71_RS06435	COG4657	Part of a membrane complex involved in electron transport
C5F71_RS06440	COG2878	Part of a membrane complex involved in electron transport
C5F71_RS06445	COG4658	electron transport chain
C5F71_RS06450	COG4659	FMN binding
C5F71_RS06460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5F71_RS06470	COG2197	response regulator
C5F71_RS06475	COG0137	argininosuccinate synthase activity
C5F71_RS06485	COG0418	dihydroorotase activity
C5F71_RS06490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F71_RS06495	COG0450	alkyl hydroperoxide reductase
C5F71_RS06510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C5F71_RS06515	COG0243	molybdopterin cofactor binding
C5F71_RS06525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5F71_RS06530	COG3842	ATPase activity
C5F71_RS06540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5F71_RS06550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5F71_RS06565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS06570	COG0765	amino acid transport
C5F71_RS06575	COG0765	amino acid transport
C5F71_RS06580	COG1126	abc transporter atp-binding protein
C5F71_RS06600	COG2204	response regulator
C5F71_RS06605	COG4191	Histidine kinase
C5F71_RS06620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F71_RS06635	COG2076	Multidrug Resistance protein
C5F71_RS06660	COG0583	DNA-binding transcription factor activity
C5F71_RS06680	COG0254	rRNA binding
C5F71_RS06685	COG0069	glutamate synthase activity
C5F71_RS06700	COG1113	amino acid transport
C5F71_RS06715	COG4886	Leucine-rich repeat (LRR) protein
C5F71_RS06745	COG1695	Transcriptional regulator
C5F71_RS06750	COG2375	cellular response to nickel ion
C5F71_RS06760	COG4628	conserved protein (DUF2132)
C5F71_RS06765	COG4206	TonB-dependent receptor
C5F71_RS06785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5F71_RS06800	COG2226	methyltransferase
C5F71_RS06805	COG0500	methyltransferase
C5F71_RS06810	COG0590	tRNA wobble adenosine to inosine editing
C5F71_RS06820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5F71_RS06825	COG1381	Involved in DNA repair and RecF pathway recombination
C5F71_RS06830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5F71_RS06835	COG0571	ribonuclease III activity
C5F71_RS06840	COG0681	Belongs to the peptidase S26 family
C5F71_RS06845	COG0481	GTPase activity
C5F71_RS06850	COG0795	lipopolysaccharide-transporting ATPase activity
C5F71_RS06855	COG0795	lipopolysaccharide-transporting ATPase activity
C5F71_RS06860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5F71_RS06875	COG0525	valine-tRNA ligase activity
C5F71_RS06880	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C5F71_RS06890	COG3081	Nucleoid-associated protein
C5F71_RS06920	COG0784	Response regulator, receiver
C5F71_RS06920	COG2205	protein histidine kinase activity
C5F71_RS06945	COG3121	Chaperone
C5F71_RS06950	COG3188	usher protein
C5F71_RS06960	COG3539	Fimbrial protein
C5F71_RS06965	COG2807	transmembrane transport
C5F71_RS06970	COG1126	abc transporter atp-binding protein
C5F71_RS06975	COG0765	amino acid transport
C5F71_RS06980	COG4597	amino acid ABC transporter
C5F71_RS06985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS06990	COG0400	carboxylic ester hydrolase activity
C5F71_RS06995	COG0513	Belongs to the DEAD box helicase family
C5F71_RS07010	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5F71_RS07015	COG0315	cyclic pyranopterin monophosphate synthase activity
C5F71_RS07020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5F71_RS07030	COG3022	response to hydroperoxide
C5F71_RS07040	COG1215	transferase activity, transferring glycosyl groups
C5F71_RS07050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS07055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C5F71_RS07065	COG3420	alginic acid biosynthetic process
C5F71_RS07085	COG1696	Membrane protein involved in D-alanine export
C5F71_RS07100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C5F71_RS07100	COG0662	Cupin 2, conserved barrel domain protein
C5F71_RS07115	COG0300	oxidoreductase activity
C5F71_RS07125	COG0477	Major facilitator Superfamily
C5F71_RS07135	COG1566	PFAM secretion protein HlyD family protein
C5F71_RS07155	COG0583	DNA-binding transcription factor activity
C5F71_RS07165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F71_RS07170	COG0835	chemotaxis
C5F71_RS07170	COG0784	Response regulator, receiver
C5F71_RS07215	COG5002	protein histidine kinase activity
C5F71_RS07225	COG2203	Gaf domain
C5F71_RS07225	COG3706	GGDEF domain
C5F71_RS07225	COG4251	negative regulation of phosphorylation
C5F71_RS07225	COG5001	Diguanylate cyclase
C5F71_RS07230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C5F71_RS07235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5F71_RS07250	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5F71_RS07255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5F71_RS07260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5F71_RS07265	COG0772	Belongs to the SEDS family
C5F71_RS07270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5F71_RS07275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5F71_RS07280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5F71_RS07285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5F71_RS07300	COG0275	rRNA processing
C5F71_RS07305	COG2001	Belongs to the MraZ family
C5F71_RS07325	COG0792	nuclease activity
C5F71_RS07330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C5F71_RS07335	COG2823	Periplasmic or secreted lipoprotein
C5F71_RS07340	COG2885	chlorophyll binding
C5F71_RS07345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5F71_RS07350	COG1944	ATP diphosphatase activity
C5F71_RS07370	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS07375	COG1280	lysine exporter protein (LysE YggA)
C5F71_RS07380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F71_RS07385	COG2813	Specifically methylates the guanine in position
C5F71_RS07390	COG2119	membrane
C5F71_RS07395	COG0501	Belongs to the peptidase M48B family
C5F71_RS07400	COG0840	transmembrane signaling receptor activity
C5F71_RS07405	COG2135	peptidase activity
C5F71_RS07460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C5F71_RS07465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5F71_RS07475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F71_RS07480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5F71_RS07485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5F71_RS07490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5F71_RS07510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5F71_RS07515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5F71_RS07520	COG1127	ABC transporter
C5F71_RS07530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C5F71_RS07540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C5F71_RS07545	COG1137	ATPase activity
C5F71_RS07550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5F71_RS07555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5F71_RS07565	COG1660	Displays ATPase and GTPase activities
C5F71_RS07600	COG0312	modulator of DNA gyrase
C5F71_RS07605	COG3028	Belongs to the UPF0307 family
C5F71_RS07610	COG0312	modulator of DNA gyrase
C5F71_RS07615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F71_RS07625	COG1530	ribonuclease E activity
C5F71_RS07630	COG0424	maF-like protein
C5F71_RS07640	COG1792	Involved in formation and maintenance of cell shape
C5F71_RS07645	COG1077	Cell shape determining protein MreB Mrl
C5F71_RS07650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5F71_RS07655	COG0154	amidase activity
C5F71_RS07660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5F71_RS07665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5F71_RS07675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F71_RS07685	COG2721	sulfolactate sulfo-lyase activity
C5F71_RS07690	COG2271	Major facilitator Superfamily
C5F71_RS07700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F71_RS07715	COG2969	positive regulation of protein catabolic process
C5F71_RS07720	COG0625	glutathione transferase activity
C5F71_RS07725	COG2857	Cytochrome c1
C5F71_RS07730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5F71_RS07735	COG0723	plastoquinol--plastocyanin reductase activity
C5F71_RS07740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5F71_RS07745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5F71_RS07750	COG0667	Aldo Keto reductase
C5F71_RS07755	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS07765	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5F71_RS07770	COG0180	Tryptophanyl-tRNA synthetase
C5F71_RS07790	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C5F71_RS07810	COG0747	negative chemotaxis
C5F71_RS07815	COG0747	negative chemotaxis
C5F71_RS07820	COG0747	negative chemotaxis
C5F71_RS07830	COG0747	negative chemotaxis
C5F71_RS07835	COG0601	transmembrane transport
C5F71_RS07840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5F71_RS07845	COG0444	Belongs to the ABC transporter superfamily
C5F71_RS07850	COG4608	Belongs to the ABC transporter superfamily
C5F71_RS07865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5F71_RS07890	COG0019	diaminopimelate decarboxylase activity
C5F71_RS07900	COG3128	pkhd-type hydroxylase
C5F71_RS07905	COG4774	siderophore transport
C5F71_RS07910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5F71_RS07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5F71_RS07915	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C5F71_RS07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5F71_RS07920	COG1105	Belongs to the carbohydrate kinase PfkB family
C5F71_RS07930	COG1609	Transcriptional regulator
C5F71_RS07935	COG0084	hydrolase, TatD family'
C5F71_RS07955	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5F71_RS08000	COG0237	dephospho-CoA kinase activity
C5F71_RS08005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C5F71_RS08035	COG1252	NADH dehydrogenase
C5F71_RS08060	COG0542	response to heat
C5F71_RS08085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS08110	COG2165	general secretion pathway protein
C5F71_RS08115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5F71_RS08120	COG1047	Peptidyl-prolyl cis-trans
C5F71_RS08125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5F71_RS08130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5F71_RS08135	COG0196	riboflavin kinase activity
C5F71_RS08140	COG0728	peptidoglycan biosynthetic process
C5F71_RS08145	COG0268	Binds directly to 16S ribosomal RNA
C5F71_RS08150	COG3045	CreA protein
C5F71_RS08155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5F71_RS08160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5F71_RS08165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5F71_RS08170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5F71_RS08175	COG0142	geranyltranstransferase activity
C5F71_RS08185	COG2824	Alkylphosphonate utilization operon protein PhnA
C5F71_RS08190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5F71_RS08195	COG0545	Peptidyl-prolyl cis-trans isomerase
C5F71_RS08200	COG2862	Uncharacterized protein family, UPF0114
C5F71_RS08215	COG1067	ATP-dependent peptidase activity
C5F71_RS08245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5F71_RS08255	COG0488	(ABC) transporter
C5F71_RS08260	COG3135	benzoate transporter
C5F71_RS08265	COG2188	Transcriptional regulator
C5F71_RS08310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5F71_RS08325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5F71_RS08330	COG0523	cobalamin synthesis protein
C5F71_RS08340	COG2879	small protein
C5F71_RS08345	COG1966	Carbon starvation protein
C5F71_RS08370	COG1970	mechanosensitive ion channel activity
C5F71_RS08380	COG2197	response regulator
C5F71_RS08385	COG2813	Specifically methylates the guanine in position
C5F71_RS08395	COG1294	oxidase, subunit
C5F71_RS08400	COG1271	oxidase subunit
C5F71_RS08415	COG2252	PERMEase
C5F71_RS08420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5F71_RS08435	COG1629	transport
C5F71_RS08435	COG4206	TonB-dependent receptor
C5F71_RS08450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5F71_RS08455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5F71_RS08460	COG1309	transcriptional regulator
C5F71_RS08465	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C5F71_RS08465	COG1082	Xylose isomerase domain protein TIM barrel
C5F71_RS08470	COG0477	Major facilitator Superfamily
C5F71_RS08485	COG2321	neutral zinc metallopeptidase
C5F71_RS08500	COG1946	Acyl-CoA thioesterase
C5F71_RS08510	COG0123	including yeast histone deacetylase and acetoin utilization protein
C5F71_RS08525	COG0513	Belongs to the DEAD box helicase family
C5F71_RS08530	COG0697	spore germination
C5F71_RS08535	COG1522	sequence-specific DNA binding
C5F71_RS08540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F71_RS08540	COG1199	ATP-dependent helicase activity
C5F71_RS08550	COG3416	Protein conserved in bacteria
C5F71_RS08565	COG1643	Atp-dependent helicase
C5F71_RS08575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5F71_RS08585	COG1522	sequence-specific DNA binding
C5F71_RS08600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5F71_RS08605	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS08610	COG2205	protein histidine kinase activity
C5F71_RS08610	COG2198	Histidine kinase
C5F71_RS08610	COG0784	Response regulator, receiver
C5F71_RS08620	COG0352	thiamine-phosphate diphosphorylase activity
C5F71_RS08625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5F71_RS08640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5F71_RS08645	COG1702	phosphate starvation-inducible protein PhoH
C5F71_RS08650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5F71_RS08655	COG4535	Mg2 and Co2 transporter CorC
C5F71_RS08660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5F71_RS08675	COG0495	leucyl-tRNA aminoacylation
C5F71_RS08695	COG2951	lytic endotransglycosylase activity
C5F71_RS08700	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5F71_RS08705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5F71_RS08710	COG0321	lipoyl(octanoyl) transferase activity
C5F71_RS08715	COG2921	Belongs to the UPF0250 family
C5F71_RS08720	COG1686	Belongs to the peptidase S11 family
C5F71_RS08730	COG2951	lytic endotransglycosylase activity
C5F71_RS08735	COG0772	Belongs to the SEDS family
C5F71_RS08740	COG0768	penicillin binding
C5F71_RS08745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5F71_RS08755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5F71_RS08760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5F71_RS08765	COG2094	Belongs to the DNA glycosylase MPG family
C5F71_RS08770	COG0586	Pfam SNARE associated Golgi protein
C5F71_RS08785	COG1346	cytolysis
C5F71_RS08805	COG0702	epimerase
C5F71_RS08820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5F71_RS08830	COG3284	Transcriptional regulator
C5F71_RS08840	COG0531	amino acid
C5F71_RS08845	COG4303	Ethanolamine ammonia lyase large subunit
C5F71_RS08850	COG4302	ethanolamine ammonia-lyase activity
C5F71_RS08855	COG0456	acetyltransferase
C5F71_RS08865	COG0586	Pfam SNARE associated Golgi protein
C5F71_RS08875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5F71_RS08900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5F71_RS08945	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5F71_RS08950	COG0789	Transcriptional regulator
C5F71_RS08960	COG3209	COG3209 Rhs family protein
C5F71_RS08960	COG3209	COG3209 Rhs family protein
C5F71_RS08975	COG1722	exodeoxyribonuclease VII activity
C5F71_RS08980	COG0142	geranyltranstransferase activity
C5F71_RS08985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5F71_RS08990	COG4206	TonB-dependent receptor
C5F71_RS08995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5F71_RS09005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5F71_RS09015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5F71_RS09020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5F71_RS09025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5F71_RS09040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5F71_RS09040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5F71_RS09045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5F71_RS09055	COG2264	protein methyltransferase activity
C5F71_RS09065	COG3118	belongs to the thioredoxin family
C5F71_RS09095	COG3047	cAMP biosynthetic process
C5F71_RS09105	COG3568	Endonuclease Exonuclease Phosphatase
C5F71_RS09110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F71_RS09115	COG0392	lysyltransferase activity
C5F71_RS09130	COG2207	Transcriptional regulator
C5F71_RS09130	COG4753	response regulator
C5F71_RS09135	COG1335	isochorismatase
C5F71_RS09140	COG4106	trans-aconitate 2-methyltransferase activity
C5F71_RS09150	COG0629	single-stranded DNA binding
C5F71_RS09155	COG2814	Major facilitator Superfamily
C5F71_RS09160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5F71_RS09165	COG2193	ferroxidase activity
C5F71_RS09175	COG0203	ribosomal protein L17
C5F71_RS09180	COG0202	RNA polymerase activity
C5F71_RS09185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5F71_RS09190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5F71_RS09195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5F71_RS09200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5F71_RS09210	COG0200	Binds to the 23S rRNA
C5F71_RS09215	COG1841	ribosomal large subunit assembly
C5F71_RS09220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5F71_RS09225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5F71_RS09230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5F71_RS09235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5F71_RS09240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5F71_RS09245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5F71_RS09250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5F71_RS09255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5F71_RS09260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5F71_RS09265	COG0255	Belongs to the universal ribosomal protein uL29 family
C5F71_RS09270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5F71_RS09275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5F71_RS09280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5F71_RS09285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5F71_RS09290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5F71_RS09295	COG0089	rRNA binding
C5F71_RS09300	COG0088	Forms part of the polypeptide exit tunnel
C5F71_RS09305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5F71_RS09310	COG0051	transcription antitermination factor activity, RNA binding
C5F71_RS09315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5F71_RS09320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5F71_RS09325	COG0049	tRNA binding
C5F71_RS09330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5F71_RS09335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5F71_RS09340	COG0085	RNA polymerase activity
C5F71_RS09345	COG0222	ribosome binding
C5F71_RS09350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5F71_RS09355	COG0081	regulation of translation
C5F71_RS09360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5F71_RS09400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5F71_RS09440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5F71_RS09450	COG0739	heme binding
C5F71_RS09455	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C5F71_RS09460	COG0316	Belongs to the HesB IscA family
C5F71_RS09465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5F71_RS09470	COG1981	membrane
C5F71_RS09490	COG0537	adenosine 5'-monophosphoramidase activity
C5F71_RS09495	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C5F71_RS09500	COG1765	OsmC-like protein
C5F71_RS09515	COG0134	indole-3-glycerol-phosphate synthase activity
C5F71_RS09520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5F71_RS09525	COG0512	Glutamine amidotransferase of anthranilate synthase
C5F71_RS09530	COG4625	pathogenesis
C5F71_RS09530	COG3240	lipase activity
C5F71_RS09535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5F71_RS09540	COG0546	phosphoglycolate phosphatase activity
C5F71_RS09550	COG1454	alcohol dehydrogenase
C5F71_RS09560	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F71_RS09570	COG3842	ATPase activity
C5F71_RS09575	COG2197	response regulator
C5F71_RS09595	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5F71_RS09600	COG3178	'Phosphotransferase
C5F71_RS09605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C5F71_RS09610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F71_RS09615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5F71_RS09620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5F71_RS09625	COG2967	ApaG domain
C5F71_RS09630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5F71_RS09635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F71_RS09640	COG2766	serine protein kinase
C5F71_RS09645	COG2718	Belongs to the UPF0229 family
C5F71_RS09650	COG2719	SpoVR family
C5F71_RS09655	COG0617	tRNA 3'-terminal CCA addition
C5F71_RS09665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5F71_RS09670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C5F71_RS09675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5F71_RS09680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5F71_RS09685	COG0358	DNA primase activity
C5F71_RS09690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5F71_RS09725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F71_RS09730	COG1025	Belongs to the peptidase M16 family
C5F71_RS09740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5F71_RS09745	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C5F71_RS09755	COG0535	radical SAM domain protein
C5F71_RS09775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F71_RS09780	COG0583	DNA-binding transcription factor activity
C5F71_RS09785	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS09790	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS09795	COG3706	GGDEF domain
C5F71_RS09800	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS09820	COG2226	methyltransferase
C5F71_RS09820	COG1073	alpha beta
C5F71_RS09825	COG0156	8-amino-7-oxononanoate synthase activity
C5F71_RS09830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5F71_RS09840	COG2005	Transcriptional regulator
C5F71_RS09840	COG3585	molybdate ion transport
C5F71_RS09845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5F71_RS09860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5F71_RS09870	COG4566	intracellular signal transduction
C5F71_RS09870	COG0745	RESPONSE REGULATOR receiver
C5F71_RS09885	COG1595	DNA-templated transcription, initiation
C5F71_RS09890	COG3712	iron ion homeostasis
C5F71_RS09895	COG4774	siderophore transport
C5F71_RS09920	COG4452	Inner membrane protein CreD
C5F71_RS09925	COG2205	protein histidine kinase activity
C5F71_RS09930	COG0745	RESPONSE REGULATOR receiver
C5F71_RS09935	COG0189	ligase activity
C5F71_RS09935	COG4067	protein conserved in archaea
C5F71_RS09940	COG0204	Acyl-transferase
C5F71_RS09955	COG1063	alcohol dehydrogenase
C5F71_RS09985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5F71_RS10005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5F71_RS10015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F71_RS10015	COG1017	nitric oxide dioxygenase activity
C5F71_RS10025	COG4638	Rieske (2fe-2S)
C5F71_RS10040	COG2181	nitrate reductase activity
C5F71_RS10040	COG0247	lactate metabolic process
C5F71_RS10045	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS10045	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5F71_RS10095	COG3246	L-lysine catabolic process to acetate
C5F71_RS10100	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F71_RS10125	COG1760	l-serine dehydratase
C5F71_RS10140	COG4175	Glycine betaine
C5F71_RS10150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5F71_RS10155	COG1309	transcriptional regulator
C5F71_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS10165	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C5F71_RS10170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5F71_RS10190	COG0477	Major facilitator Superfamily
C5F71_RS10195	COG0513	Belongs to the DEAD box helicase family
C5F71_RS10200	COG2081	HI0933 family
C5F71_RS10210	COG1289	transmembrane transporter activity
C5F71_RS10220	COG2153	protein acetylation
C5F71_RS10230	COG1451	nucleotide metabolic process
C5F71_RS10265	COG0126	phosphoglycerate kinase activity
C5F71_RS10270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5F71_RS10275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5F71_RS10280	COG0640	Transcriptional regulator
C5F71_RS10285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5F71_RS10295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5F71_RS10300	COG1422	Protein of unknown function (DUF1090)
C5F71_RS10335	COG1204	response to ionizing radiation
C5F71_RS10380	COG0640	Transcriptional regulator
C5F71_RS10385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5F71_RS10390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5F71_RS10395	COG0431	NADPH-dependent FMN reductase
C5F71_RS10405	COG2072	flavoprotein involved in K transport
C5F71_RS10420	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5F71_RS10425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5F71_RS10440	COG0789	Transcriptional regulator
C5F71_RS10470	COG0210	DNA helicase
C5F71_RS10475	COG1196	nuclear chromosome segregation
C5F71_RS10495	COG2433	Pfam Transposase IS66
C5F71_RS10500	COG2169	Transcriptional regulator
C5F71_RS10500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5F71_RS10630	COG2116	formate transmembrane transporter activity
C5F71_RS10640	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5F71_RS10650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5F71_RS10660	COG0513	Belongs to the DEAD box helicase family
C5F71_RS10670	COG2353	YceI-like domain
C5F71_RS10675	COG3038	cytochrome b561
C5F71_RS10685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5F71_RS10690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS10710	COG1272	protein, Hemolysin III
C5F71_RS10730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5F71_RS10750	COG3052	prosthetic group binding
C5F71_RS10755	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5F71_RS10800	COG0643	Histidine kinase
C5F71_RS10800	COG0784	Response regulator, receiver
C5F71_RS10800	COG2198	Histidine kinase
C5F71_RS10825	COG0189	ligase activity
C5F71_RS10840	COG1678	Uncharacterized ACR, COG1678
C5F71_RS10845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5F71_RS10850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5F71_RS10855	COG0540	Belongs to the ATCase OTCase family
C5F71_RS10860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5F71_RS10870	COG0791	NLP P60 protein
C5F71_RS10900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F71_RS10905	COG2813	Specifically methylates the guanine in position
C5F71_RS10905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F71_RS10915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5F71_RS10920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5F71_RS10930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5F71_RS10935	COG2022	thiamine diphosphate biosynthetic process
C5F71_RS10945	COG2363	Small membrane protein
C5F71_RS10950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5F71_RS10960	COG2177	Part of the ABC transporter FtsEX involved in
C5F71_RS10965	COG2884	Cell division ATP-binding protein ftsE
C5F71_RS10970	COG0552	protein localization to endoplasmic reticulum
C5F71_RS10975	COG0612	Peptidase, M16
C5F71_RS10980	COG0612	Peptidase, M16
C5F71_RS10985	COG0742	ribosomal rna small subunit methyltransferase
C5F71_RS10990	COG0429	hydrolase of the alpha beta-hydrolase fold
C5F71_RS11000	COG1309	transcriptional regulator
C5F71_RS11015	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C5F71_RS11020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5F71_RS11025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5F71_RS11030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5F71_RS11045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5F71_RS11055	COG0129	dihydroxy-acid dehydratase activity
C5F71_RS11070	COG1823	symporter activity
C5F71_RS11085	COG1160	GTP binding
C5F71_RS11100	COG1840	ABC-type Fe3 transport system, periplasmic component
C5F71_RS11105	COG1178	ABC-type Fe3 transport system permease component
C5F71_RS11110	COG3842	ATPase activity
C5F71_RS11115	COG0583	DNA-binding transcription factor activity
C5F71_RS11125	COG0789	Transcriptional regulator
C5F71_RS11130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5F71_RS11135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5F71_RS11145	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C5F71_RS11150	COG0494	nUDIX hydrolase
C5F71_RS11165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5F71_RS11170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5F71_RS11175	COG2234	aminopeptidase activity
C5F71_RS11180	COG3204	pilus organization
C5F71_RS11185	COG3204	pilus organization
C5F71_RS11190	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5F71_RS11195	COG0277	FAD linked oxidase domain protein
C5F71_RS11205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5F71_RS11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS11220	COG1683	Conserved Protein
C5F71_RS11250	COG1917	Cupin 2, conserved barrel domain protein
C5F71_RS11250	COG4977	sequence-specific DNA binding
C5F71_RS11255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F71_RS11270	COG1177	transmembrane transport
C5F71_RS11275	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F71_RS11280	COG3842	ATPase activity
C5F71_RS11300	COG0174	glutamine synthetase
C5F71_RS11305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5F71_RS11310	COG0174	glutamine synthetase
C5F71_RS11325	COG1116	anion transmembrane transporter activity
C5F71_RS11330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F71_RS11335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F71_RS11340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5F71_RS11345	COG0431	NADPH-dependent FMN reductase
C5F71_RS11350	COG0450	alkyl hydroperoxide reductase
C5F71_RS11360	COG4521	taurine ABC transporter
C5F71_RS11365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5F71_RS11365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5F71_RS11380	COG1522	sequence-specific DNA binding
C5F71_RS11390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5F71_RS11395	COG0330	HflC and HflK could
C5F71_RS11410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5F71_RS11415	COG0509	glycine decarboxylation via glycine cleavage system
C5F71_RS11420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F71_RS11425	COG1178	ABC-type Fe3 transport system permease component
C5F71_RS11435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F71_RS11445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F71_RS11450	COG0006	proline dipeptidase activity
C5F71_RS11455	COG3079	Belongs to the UPF0149 family
C5F71_RS11475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5F71_RS11485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS11490	COG0842	Transport permease protein
C5F71_RS11490	COG1129	ABC transporter
C5F71_RS11495	COG0842	Transport permease protein
C5F71_RS11510	COG2271	Major facilitator Superfamily
C5F71_RS11535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5F71_RS11550	COG2186	Transcriptional regulator
C5F71_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS11565	COG0765	amino acid transport
C5F71_RS11570	COG0765	amino acid transport
C5F71_RS11575	COG1126	abc transporter atp-binding protein
C5F71_RS11585	COG3188	usher protein
C5F71_RS11590	COG3121	Chaperone
C5F71_RS11600	COG0248	Ppx GppA phosphatase
C5F71_RS11605	COG0154	amidase activity
C5F71_RS11610	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5F71_RS11620	COG0586	Pfam SNARE associated Golgi protein
C5F71_RS11630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C5F71_RS11635	COG0672	)-iron permease
C5F71_RS11660	COG1280	lysine exporter protein (LysE YggA)
C5F71_RS11670	COG0488	(ABC) transporter
C5F71_RS11695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C5F71_RS11715	COG0181	hydroxymethylbilane synthase activity
C5F71_RS11730	COG0165	Argininosuccinate lyase
C5F71_RS11735	COG0625	glutathione transferase activity
C5F71_RS11755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F71_RS11765	COG1965	Belongs to the frataxin family
C5F71_RS11775	COG0019	diaminopimelate decarboxylase activity
C5F71_RS11780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5F71_RS11790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5F71_RS11795	COG1011	Hydrolase
C5F71_RS11810	COG0004	ammonium transporteR
C5F71_RS11815	COG0347	Belongs to the P(II) protein family
C5F71_RS11830	COG0606	chelatase, subunit chli
C5F71_RS11845	COG0840	transmembrane signaling receptor activity
C5F71_RS11850	COG0583	DNA-binding transcription factor activity
C5F71_RS11855	COG0534	Mate efflux family protein
C5F71_RS11870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5F71_RS11880	COG0427	acetyl-CoA hydrolase
C5F71_RS11895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5F71_RS11900	COG0251	oxidation-reduction process
C5F71_RS11905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS11920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS11930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS11935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F71_RS11950	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS11960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5F71_RS11965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5F71_RS11970	COG0747	negative chemotaxis
C5F71_RS11975	COG2003	Belongs to the UPF0758 family
C5F71_RS11980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5F71_RS11985	COG0756	dUTP diphosphatase activity
C5F71_RS11990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5F71_RS11995	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5F71_RS12000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5F71_RS12005	COG0708	Exodeoxyribonuclease III
C5F71_RS12015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C5F71_RS12020	COG1561	YicC-like family, N-terminal region
C5F71_RS12025	COG0194	GDP metabolic process
C5F71_RS12030	COG1758	RNA polymerase activity
C5F71_RS12035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5F71_RS12060	COG0848	biopolymer transport protein
C5F71_RS12070	COG0583	DNA-binding transcription factor activity
C5F71_RS12075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5F71_RS12105	COG1136	(ABC) transporter
C5F71_RS12110	COG2815	serine threonine protein kinase
C5F71_RS12110	COG0515	serine threonine protein kinase
C5F71_RS12225	COG3209	COG3209 Rhs family protein
C5F71_RS12250	COG3161	chorismate lyase activity
C5F71_RS12255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C5F71_RS12275	COG1253	flavin adenine dinucleotide binding
C5F71_RS12280	COG0739	heme binding
C5F71_RS12290	COG0704	Plays a role in the regulation of phosphate uptake
C5F71_RS12295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5F71_RS12300	COG0573	inorganic phosphate transmembrane transporter activity
C5F71_RS12320	COG0477	Major facilitator Superfamily
C5F71_RS12325	COG1607	acyl-coa hydrolase
C5F71_RS12355	COG0583	DNA-binding transcription factor activity
C5F71_RS12360	COG1027	Aspartate ammonia-lyase
C5F71_RS12375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F71_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS12395	COG1414	Transcriptional regulator
C5F71_RS12415	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS12425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F71_RS12445	COG0251	oxidation-reduction process
C5F71_RS12460	COG1115	amino acid carrier protein
C5F71_RS12465	COG0252	asparaginase activity
C5F71_RS12515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS12520	COG0765	amino acid transport
C5F71_RS12540	COG5016	pyruvate
C5F71_RS12540	COG0511	ligase activity, forming carbon-carbon bonds
C5F71_RS12545	COG0439	Biotin carboxylase
C5F71_RS12550	COG0583	DNA-binding transcription factor activity
C5F71_RS12570	COG0210	DNA helicase
C5F71_RS12610	COG4651	solute:proton antiporter activity
C5F71_RS12610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5F71_RS12615	COG1607	acyl-coa hydrolase
C5F71_RS12625	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C5F71_RS12635	COG0523	cobalamin synthesis protein
C5F71_RS12660	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5F71_RS12665	COG1469	GTP cyclohydrolase I activity
C5F71_RS12670	COG1121	(ABC) transporter
C5F71_RS12685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5F71_RS12695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5F71_RS12705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F71_RS12715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5F71_RS12725	COG3220	belongs to the UPF0276 family
C5F71_RS12735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5F71_RS12740	COG2267	carboxylic ester hydrolase activity
C5F71_RS12745	COG2453	phosphatase
C5F71_RS12745	COG0671	phosphoesterase, PA-phosphatase related
C5F71_RS12760	COG4589	Belongs to the CDS family
C5F71_RS12800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F71_RS12805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5F71_RS12810	COG1349	DNA-binding transcription factor activity
C5F71_RS12815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5F71_RS12825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5F71_RS12830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5F71_RS12835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5F71_RS12840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5F71_RS12845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5F71_RS12850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5F71_RS12860	COG0356	it plays a direct role in the translocation of protons across the membrane
C5F71_RS12865	COG3312	ion transport
C5F71_RS12870	COG1475	DNA binding
C5F71_RS12875	COG1192	Involved in chromosome partitioning
C5F71_RS12880	COG0357	Ribosomal RNA small subunit methyltransferase G
C5F71_RS12885	COG0445	tRNA wobble uridine modification
C5F71_RS12895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5F71_RS12900	COG0706	membrane insertase activity
C5F71_RS12905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5F71_RS12910	COG0594	ribonuclease P activity
C5F71_RS12915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5F71_RS12920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5F71_RS12925	COG0592	DNA-directed DNA polymerase activity
C5F71_RS12930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5F71_RS12935	COG0187	DNA topoisomerase II activity
C5F71_RS12940	COG0745	RESPONSE REGULATOR receiver
C5F71_RS12955	COG5002	protein histidine kinase activity
C5F71_RS12965	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5F71_RS12970	COG0751	glycine-tRNA ligase activity
C5F71_RS12975	COG0752	glycyl-tRNA synthetase alpha subunit
C5F71_RS12980	COG2818	Glycosylase
C5F71_RS12995	COG0569	domain protein
C5F71_RS13000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5F71_RS13005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5F71_RS13010	COG0242	peptide deformylase activity
C5F71_RS13015	COG0758	DNA mediated transformation
C5F71_RS13020	COG0009	L-threonylcarbamoyladenylate synthase
C5F71_RS13030	COG0408	coproporphyrinogen oxidase activity
C5F71_RS13035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5F71_RS13050	COG3119	arylsulfatase activity
C5F71_RS13055	COG0583	DNA-binding transcription factor activity
C5F71_RS13065	COG3734	2-keto-3-deoxy-galactonokinase
C5F71_RS13070	COG0800	Aldolase
C5F71_RS13075	COG4948	Mandelate Racemase Muconate Lactonizing
C5F71_RS13080	COG2271	Major facilitator Superfamily
C5F71_RS13085	COG0159	tryptophan synthase activity
C5F71_RS13105	COG3360	Dodecin
C5F71_RS13115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F71_RS13120	COG1764	response to oxidative stress
C5F71_RS13145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5F71_RS13150	COG0339	signal peptide processing
C5F71_RS13185	COG0659	secondary active sulfate transmembrane transporter activity
C5F71_RS13195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5F71_RS13200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5F71_RS13205	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C5F71_RS13235	COG0109	protoheme IX farnesyltransferase activity
C5F71_RS13250	COG2011	ABC-type metal ion transport system permease component
C5F71_RS13255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5F71_RS13270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5F71_RS13275	COG1121	(ABC) transporter
C5F71_RS13280	COG0735	belongs to the Fur family
C5F71_RS13285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C5F71_RS13305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5F71_RS13310	COG3245	cytochrome
C5F71_RS13320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5F71_RS13335	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5F71_RS13340	COG5002	protein histidine kinase activity
C5F71_RS13345	COG2204	response regulator
C5F71_RS13355	COG5487	UPF0391 membrane protein
C5F71_RS13365	COG1301	dicarboxylic acid transport
C5F71_RS13370	COG0700	Nucleoside recognition
C5F71_RS13385	COG1127	ABC transporter
C5F71_RS13390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5F71_RS13400	COG0612	Peptidase, M16
C5F71_RS13405	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5F71_RS13410	COG0861	Integral membrane protein TerC family
C5F71_RS13415	COG2851	Citrate transporter
C5F71_RS13445	COG0427	acetyl-CoA hydrolase
C5F71_RS13465	COG0583	DNA-binding transcription factor activity
C5F71_RS13470	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS13475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F71_RS13515	COG0840	transmembrane signaling receptor activity
C5F71_RS13540	COG1802	Transcriptional regulator
C5F71_RS13550	COG5001	Diguanylate cyclase
C5F71_RS13550	COG3300	MHYT domain
C5F71_RS13565	COG1538	Outer membrane efflux protein
C5F71_RS13570	COG2274	protein secretion by the type I secretion system
C5F71_RS13575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS13585	COG2175	clavaminate synthase activity
C5F71_RS13600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F71_RS13625	COG1595	DNA-templated transcription, initiation
C5F71_RS13630	COG3712	iron ion homeostasis
C5F71_RS13635	COG4774	siderophore transport
C5F71_RS13660	COG1289	transmembrane transporter activity
C5F71_RS13670	COG1566	PFAM secretion protein HlyD family protein
C5F71_RS13685	COG5339	Protein conserved in bacteria
C5F71_RS13690	COG0457	Tetratricopeptide repeat
C5F71_RS13695	COG1649	PFAM Uncharacterised BCR, COG1649
C5F71_RS13695	COG0726	polysaccharide deacetylase
C5F71_RS13700	COG1215	transferase activity, transferring glycosyl groups
C5F71_RS13790	COG2304	oxidoreductase activity
C5F71_RS13795	COG1595	DNA-templated transcription, initiation
C5F71_RS13810	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS13815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5F71_RS13820	COG2205	protein histidine kinase activity
C5F71_RS13820	COG5002	protein histidine kinase activity
C5F71_RS13820	COG0784	Response regulator, receiver
C5F71_RS13825	COG2199	diguanylate cyclase activity
C5F71_RS13850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C5F71_RS13860	COG4208	sulfate ABC transporter
C5F71_RS13865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5F71_RS13890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F71_RS13895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5F71_RS13930	COG2807	transmembrane transport
C5F71_RS13935	COG0590	tRNA wobble adenosine to inosine editing
C5F71_RS13945	COG0583	DNA-binding transcription factor activity
C5F71_RS13985	COG0765	amino acid transport
C5F71_RS13990	COG0765	amino acid transport
C5F71_RS13995	COG1126	abc transporter atp-binding protein
C5F71_RS14000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS14045	COG2011	ABC-type metal ion transport system permease component
C5F71_RS14050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5F71_RS14055	COG1464	Belongs to the NlpA lipoprotein family
C5F71_RS14085	COG0765	amino acid transport
C5F71_RS14090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS14100	COG1045	serine acetyltransferase
C5F71_RS14105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5F71_RS14110	COG2175	clavaminate synthase activity
C5F71_RS14115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F71_RS14120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5F71_RS14125	COG4521	taurine ABC transporter
C5F71_RS14130	COG2918	glutathione biosynthetic process
C5F71_RS14140	COG2183	response to ionizing radiation
C5F71_RS14150	COG2205	protein histidine kinase activity
C5F71_RS14155	COG0189	ligase activity
C5F71_RS14160	COG0189	ligase activity
C5F71_RS14160	COG4067	protein conserved in archaea
C5F71_RS14165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5F71_RS14175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5F71_RS14180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C5F71_RS14200	COG0514	ATP-dependent DNA helicase (RecQ)
C5F71_RS14205	COG0824	Thioesterase
C5F71_RS14215	COG0243	molybdopterin cofactor binding
C5F71_RS14220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5F71_RS14230	COG1652	LysM domain
C5F71_RS14235	COG1011	Hydrolase
C5F71_RS14240	COG0494	nUDIX hydrolase
C5F71_RS14245	COG1218	3'(2'),5'-bisphosphate nucleotidase
C5F71_RS14270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C5F71_RS14280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5F71_RS14290	COG2957	Belongs to the agmatine deiminase family
C5F71_RS14330	COG3712	iron ion homeostasis
C5F71_RS14335	COG1595	DNA-templated transcription, initiation
C5F71_RS14350	COG2207	Transcriptional regulator
C5F71_RS14360	COG4249	Peptidase C14 caspase catalytic subunit p20
C5F71_RS14395	COG0582	viral genome integration into host DNA
C5F71_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS14460	COG4774	siderophore transport
C5F71_RS14475	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C5F71_RS14480	COG1194	a g-specific adenine glycosylase
C5F71_RS14490	COG2223	nitrite transmembrane transporter activity
C5F71_RS14495	COG0131	Imidazoleglycerol-phosphate dehydratase
C5F71_RS14500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5F71_RS14510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5F71_RS14515	COG0107	imidazoleglycerol-phosphate synthase activity
C5F71_RS14525	COG2861	carbohydrate metabolic process
C5F71_RS14530	COG0793	Belongs to the peptidase S41A family
C5F71_RS14535	COG4942	peptidase
C5F71_RS14540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5F71_RS14545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F71_RS14555	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C5F71_RS14560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5F71_RS14580	COG3852	Histidine kinase
C5F71_RS14595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F71_RS14595	COG0301	tRNA thio-modification
C5F71_RS14600	COG1217	gtp-binding protein TYPA
C5F71_RS14610	COG0058	SHG alpha-glucan phosphorylase activity
C5F71_RS14625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C5F71_RS14645	COG0583	DNA-binding transcription factor activity
C5F71_RS14650	COG0402	S-adenosylhomocysteine deaminase activity
C5F71_RS14655	COG2188	Transcriptional regulator
C5F71_RS14665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5F71_RS14670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5F71_RS14680	COG4176	ABC-type proline glycine betaine transport system permease component
C5F71_RS14685	COG4175	Glycine betaine
C5F71_RS14685	COG0517	IMP dehydrogenase activity
C5F71_RS14690	COG2986	histidine ammonia-lyase
C5F71_RS14695	COG2986	histidine ammonia-lyase
C5F71_RS14700	COG1113	amino acid transport
C5F71_RS14705	COG1228	amidohydrolase
C5F71_RS14725	COG1490	D-aminoacyl-tRNA deacylase activity
C5F71_RS14730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C5F71_RS14735	COG2943	transferase activity, transferring hexosyl groups
C5F71_RS14745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS14750	COG0765	amino acid transport
C5F71_RS14755	COG1126	abc transporter atp-binding protein
C5F71_RS14760	COG0840	transmembrane signaling receptor activity
C5F71_RS14765	COG0840	transmembrane signaling receptor activity
C5F71_RS14780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5F71_RS14785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5F71_RS14790	COG0140	phosphoribosyl-ATP diphosphatase activity
C5F71_RS14795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5F71_RS14800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5F71_RS14810	COG2226	methyltransferase
C5F71_RS14845	COG3121	Chaperone
C5F71_RS14850	COG3121	Chaperone
C5F71_RS14860	COG2201	protein-glutamate methylesterase activity
C5F71_RS14865	COG1309	transcriptional regulator
C5F71_RS14890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5F71_RS14895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5F71_RS14905	COG0018	arginyl-trna synthetase
C5F71_RS14910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5F71_RS14920	COG0254	rRNA binding
C5F71_RS14930	COG0281	malic enzyme
C5F71_RS14970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5F71_RS14975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5F71_RS14990	COG0070	glutamate synthase
C5F71_RS14990	COG0069	glutamate synthase activity
C5F71_RS14990	COG0067	glutamate synthase
C5F71_RS14995	COG0493	'glutamate synthase
C5F71_RS15000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5F71_RS15015	COG2814	Major facilitator Superfamily
C5F71_RS15020	COG0583	DNA-binding transcription factor activity
C5F71_RS15030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F71_RS15035	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS15045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F71_RS15055	COG2226	methyltransferase
C5F71_RS15080	COG2986	histidine ammonia-lyase
C5F71_RS15095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5F71_RS15105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5F71_RS15125	COG1192	Involved in chromosome partitioning
C5F71_RS15130	COG3118	belongs to the thioredoxin family
C5F71_RS15135	COG5499	transcription regulator containing HTH domain
C5F71_RS15140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C5F71_RS15145	COG3264	Mechanosensitive ion channel
C5F71_RS15145	COG1196	nuclear chromosome segregation
C5F71_RS15150	COG3263	regulation of cellular component size
C5F71_RS15170	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS15175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5F71_RS15175	COG0506	proline dehydrogenase activity
C5F71_RS15175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5F71_RS15185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5F71_RS15200	COG2873	o-acetylhomoserine
C5F71_RS15205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5F71_RS15210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5F71_RS15235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C5F71_RS15240	COG0859	PFAM glycosyl transferase family 9
C5F71_RS15245	COG0859	PFAM glycosyl transferase family 9
C5F71_RS15250	COG0438	transferase activity, transferring glycosyl groups
C5F71_RS15260	COG3642	lipopolysaccharide core region biosynthetic process
C5F71_RS15270	COG0515	serine threonine protein kinase
C5F71_RS15280	COG4772	TonB-dependent receptor
C5F71_RS15290	COG2192	nodulation
C5F71_RS15295	COG1215	transferase activity, transferring glycosyl groups
C5F71_RS15310	COG1132	(ABC) transporter
C5F71_RS15315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5F71_RS15315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5F71_RS15320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F71_RS15330	COG0667	Aldo Keto reductase
C5F71_RS15345	COG0583	DNA-binding transcription factor activity
C5F71_RS15350	COG1519	Transferase
C5F71_RS15355	COG1538	Outer membrane efflux protein
C5F71_RS15360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5F71_RS15375	COG0494	nUDIX hydrolase
C5F71_RS15385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5F71_RS15390	COG3150	esterase
C5F71_RS15425	COG3830	Belongs to the UPF0237 family
C5F71_RS15425	COG0560	Phosphoserine phosphatase
C5F71_RS15430	COG0688	phosphatidylethanolamine metabolic process
C5F71_RS15455	COG1162	GTPase activity
C5F71_RS15460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C5F71_RS15465	COG2860	membrane
C5F71_RS15475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5F71_RS15475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5F71_RS15480	COG0802	atpase or kinase
C5F71_RS15485	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5F71_RS15490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5F71_RS15495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5F71_RS15500	COG1923	regulation of RNA biosynthetic process
C5F71_RS15505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5F71_RS15510	COG0330	HflC and HflK could
C5F71_RS15515	COG0330	HflC and HflK could
C5F71_RS15520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C5F71_RS15525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5F71_RS15535	COG1178	ABC-type Fe3 transport system permease component
C5F71_RS15540	COG1840	ABC-type Fe3 transport system, periplasmic component
C5F71_RS15555	COG0557	exoribonuclease II activity
C5F71_RS15560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5F71_RS15565	COG0360	Binds together with S18 to 16S ribosomal RNA
C5F71_RS15570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5F71_RS15580	COG0359	binds to the 23S rRNA
C5F71_RS15585	COG0305	Participates in initiation and elongation during chromosome replication
C5F71_RS15595	COG1032	radical SAM domain protein
C5F71_RS15615	COG2307	Protein conserved in bacteria
C5F71_RS15615	COG2308	Evidence 4 Homologs of previously reported genes of
C5F71_RS15635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5F71_RS15640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5F71_RS15645	COG0583	DNA-binding transcription factor activity
C5F71_RS15650	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS15655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS15690	COG4221	oxidoreductase activity
C5F71_RS15715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5F71_RS15720	COG0830	nickel cation binding
C5F71_RS15725	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C5F71_RS15730	COG0791	NLP P60 protein
C5F71_RS15735	COG1309	transcriptional regulator
C5F71_RS15745	COG2982	Protein involved in outer membrane biogenesis
C5F71_RS15755	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5F71_RS15760	COG0697	spore germination
C5F71_RS15790	COG0443	Heat shock 70 kDa protein
C5F71_RS15800	COG0484	heat shock protein binding
C5F71_RS15810	COG0804	urea catabolic process
C5F71_RS15815	COG0832	Belongs to the urease beta subunit family
C5F71_RS15830	COG0831	urea catabolic process
C5F71_RS15835	COG0829	nickel cation binding
C5F71_RS15845	COG0411	ABC transporter
C5F71_RS15860	COG0683	leucine binding
C5F71_RS15870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5F71_RS15880	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5F71_RS15955	COG2095	MarC family integral membrane protein
C5F71_RS15965	COG0151	Belongs to the GarS family
C5F71_RS15970	COG0138	bifunctional purine biosynthesis protein purh
C5F71_RS15980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5F71_RS15990	COG2264	protein methyltransferase activity
C5F71_RS16005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5F71_RS16030	COG0023	Translation Initiation Factor
C5F71_RS16035	COG1166	arginine decarboxylase activity
C5F71_RS16040	COG0534	Mate efflux family protein
C5F71_RS16045	COG2373	Large extracellular alpha-helical protein
C5F71_RS16055	COG4953	penicillin-binding protein 1C
C5F71_RS16065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5F71_RS16135	COG4964	Belongs to the GSP D family
C5F71_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS16200	COG2217	Heavy metal translocating P-type atpase
C5F71_RS16215	COG2814	Major facilitator Superfamily
C5F71_RS16225	COG0604	alcohol dehydrogenase
C5F71_RS16230	COG0583	DNA-binding transcription factor activity
C5F71_RS16240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5F71_RS16245	COG0387	Pfam Sodium calcium exchanger
C5F71_RS16270	COG1309	transcriptional regulator
C5F71_RS16275	COG2233	PERMEase
C5F71_RS16325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5F71_RS16330	COG1074	ATP-dependent DNA helicase activity
C5F71_RS16335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5F71_RS16375	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C5F71_RS16380	COG3483	tryptophan 2,3-dioxygenase activity
C5F71_RS16385	COG1113	amino acid transport
C5F71_RS16390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F71_RS16390	COG0543	2 iron, 2 sulfur cluster binding
C5F71_RS16395	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C5F71_RS16400	COG4638	Rieske (2fe-2S)
C5F71_RS16415	COG4948	Mandelate Racemase Muconate Lactonizing
C5F71_RS16420	COG4829	muconolactone delta-isomerase
C5F71_RS16425	COG3485	protocatechuate 3,4-dioxygenase
C5F71_RS16430	COG1522	sequence-specific DNA binding
C5F71_RS16440	COG1113	amino acid transport
C5F71_RS16445	COG0583	DNA-binding transcription factor activity
C5F71_RS16460	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5F71_RS16465	COG0583	DNA-binding transcription factor activity
C5F71_RS16470	COG0659	secondary active sulfate transmembrane transporter activity
C5F71_RS16480	COG2610	gluconate transmembrane transporter activity
C5F71_RS16490	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C5F71_RS16500	COG0840	transmembrane signaling receptor activity
C5F71_RS16510	COG1288	antiporter activity
C5F71_RS16540	COG3135	benzoate transporter
C5F71_RS16550	COG1595	DNA-templated transcription, initiation
C5F71_RS16555	COG3712	iron ion homeostasis
C5F71_RS16565	COG0583	DNA-binding transcription factor activity
C5F71_RS16570	COG3048	D-serine ammonia-lyase activity
C5F71_RS16575	COG2610	gluconate transmembrane transporter activity
C5F71_RS16615	COG1401	restriction endodeoxyribonuclease activity
C5F71_RS16625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5F71_RS16640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5F71_RS16665	COG1620	l-lactate permease
C5F71_RS16670	COG2186	Transcriptional regulator
C5F71_RS16675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5F71_RS16685	COG2914	Belongs to the UPF0125 (RnfH) family
C5F71_RS16690	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5F71_RS16695	COG0735	belongs to the Fur family
C5F71_RS16700	COG0497	DNA recombination
C5F71_RS16705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5F71_RS16710	COG0443	Heat shock 70 kDa protein
C5F71_RS16715	COG0484	heat shock protein binding
C5F71_RS16720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5F71_RS16725	COG0505	Belongs to the CarA family
C5F71_RS16730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5F71_RS16735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F71_RS16750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C5F71_RS16760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5F71_RS16765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5F71_RS16770	COG0149	triose-phosphate isomerase activity
C5F71_RS16775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5F71_RS16790	COG0779	Required for maturation of 30S ribosomal subunits
C5F71_RS16795	COG0195	Participates in both transcription termination and antitermination
C5F71_RS16800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5F71_RS16805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5F71_RS16810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5F71_RS16815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5F71_RS16820	COG1185	polyribonucleotide nucleotidyltransferase activity
C5F71_RS16825	COG2823	Periplasmic or secreted lipoprotein
C5F71_RS16835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5F71_RS16845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F71_RS16850	COG0166	Belongs to the GPI family
C5F71_RS16855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5F71_RS16860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5F71_RS16880	COG4191	Histidine kinase
C5F71_RS16890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5F71_RS16900	COG0436	Aminotransferase
C5F71_RS16905	COG1489	DNA binding
C5F71_RS16915	COG4558	Periplasmic binding protein
C5F71_RS16920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5F71_RS16925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5F71_RS16945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5F71_RS16955	COG3098	single-species biofilm formation
C5F71_RS16960	COG0028	Belongs to the TPP enzyme family
C5F71_RS16970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5F71_RS16975	COG1183	phosphatidylcholine synthase activity
C5F71_RS16980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5F71_RS16985	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C5F71_RS17020	COG2995	paraquat-inducible protein a
C5F71_RS17025	COG2995	paraquat-inducible protein a
C5F71_RS17030	COG3008	intermembrane lipid transfer
C5F71_RS17055	COG0456	acetyltransferase
C5F71_RS17065	COG0288	reversible hydration of carbon dioxide
C5F71_RS17090	COG2031	fatty acid transporter
C5F71_RS17120	COG0642	Histidine kinase
C5F71_RS17165	COG2207	Transcriptional regulator
C5F71_RS17175	COG0405	Gamma-glutamyltransferase
C5F71_RS17180	COG1595	DNA-templated transcription, initiation
C5F71_RS17195	COG4771	TonB-dependent receptor
C5F71_RS17205	COG1132	(ABC) transporter
C5F71_RS17245	COG4638	Rieske (2fe-2S)
C5F71_RS17260	COG4983	Phage plasmid primase, P4 family domain protein
C5F71_RS17280	COG0582	viral genome integration into host DNA
C5F71_RS17290	COG2223	nitrite transmembrane transporter activity
C5F71_RS17340	COG4794	Type iii secretion
C5F71_RS17350	COG4792	protein secretion
C5F71_RS17390	COG4669	(LipO)protein
C5F71_RS17405	COG0012	GTP binding
C5F71_RS17410	COG0193	aminoacyl-tRNA hydrolase activity
C5F71_RS17415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5F71_RS17420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5F71_RS17430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5F71_RS17435	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C5F71_RS17445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5F71_RS17450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5F71_RS17460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5F71_RS17465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5F71_RS17485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5F71_RS17495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C5F71_RS17500	COG4221	oxidoreductase activity
C5F71_RS17510	COG0415	Belongs to the DNA photolyase family
C5F71_RS17515	COG0789	Transcriptional regulator
C5F71_RS17530	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C5F71_RS17535	COG1090	epimerase
C5F71_RS17555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5F71_RS17570	COG0175	sulfate reduction
C5F71_RS17580	COG0204	Acyl-transferase
C5F71_RS17585	COG0280	phosphate acetyltransferase
C5F71_RS17585	COG0857	belongs to the CobB CobQ family
C5F71_RS17595	COG1047	Peptidyl-prolyl cis-trans
C5F71_RS17600	COG0386	Belongs to the glutathione peroxidase family
C5F71_RS17615	COG1858	cytochrome C peroxidase
C5F71_RS17620	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C5F71_RS17625	COG0492	ferredoxin-NADP+ reductase activity
C5F71_RS17640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5F71_RS17665	COG1366	Belongs to the anti-sigma-factor antagonist family
C5F71_RS17675	COG0583	DNA-binding transcription factor activity
C5F71_RS17680	COG1380	Effector of murein hydrolase LrgA
C5F71_RS17685	COG1346	cytolysis
C5F71_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS17715	COG2197	response regulator
C5F71_RS17725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C5F71_RS17730	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5F71_RS17750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5F71_RS17780	COG0814	amino acid
C5F71_RS17785	COG1760	l-serine dehydratase
C5F71_RS17790	COG0583	DNA-binding transcription factor activity
C5F71_RS17805	COG4772	TonB-dependent receptor
C5F71_RS17810	COG3712	iron ion homeostasis
C5F71_RS17815	COG1595	DNA-templated transcription, initiation
C5F71_RS17845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5F71_RS17850	COG4774	siderophore transport
C5F71_RS17855	COG2027	D-alanyl-D-alanine carboxypeptidase
C5F71_RS17860	COG2207	Transcriptional regulator
C5F71_RS17865	COG0697	spore germination
C5F71_RS17870	COG3604	Transcriptional regulator
C5F71_RS17875	COG1017	nitric oxide dioxygenase activity
C5F71_RS17875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F71_RS17880	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C5F71_RS17890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5F71_RS17895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5F71_RS17900	COG1845	cytochrome c oxidase, subunit III
C5F71_RS17910	COG0109	protoheme IX farnesyltransferase activity
C5F71_RS17990	COG4251	negative regulation of phosphorylation
C5F71_RS18030	COG0583	DNA-binding transcription factor activity
C5F71_RS18110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5F71_RS18115	COG0601	transmembrane transport
C5F71_RS18130	COG4172	Belongs to the ABC transporter superfamily
C5F71_RS18160	COG3437	response regulator, receiver
C5F71_RS18185	COG0582	viral genome integration into host DNA
C5F71_RS18195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5F71_RS18200	COG0343	queuine tRNA-ribosyltransferase activity
C5F71_RS18205	COG1862	Preprotein translocase
C5F71_RS18220	COG3134	Outer membrane lipoprotein
C5F71_RS18235	COG1045	serine acetyltransferase
C5F71_RS18245	COG1104	cysteine desulfurase activity
C5F71_RS18255	COG0316	Belongs to the HesB IscA family
C5F71_RS18260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C5F71_RS18265	COG0443	Heat shock 70 kDa protein
C5F71_RS18270	COG0633	Ferredoxin
C5F71_RS18280	COG0105	UTP biosynthetic process
C5F71_RS18285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5F71_RS18295	COG1426	Protein conserved in bacteria
C5F71_RS18300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5F71_RS18305	COG0124	histidyl-tRNA synthetase
C5F71_RS18320	COG1160	GTP binding
C5F71_RS18325	COG0436	Aminotransferase
C5F71_RS18330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F71_RS18335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5F71_RS18340	COG0739	heme binding
C5F71_RS18345	COG1570	exodeoxyribonuclease VII activity
C5F71_RS18375	COG0519	Catalyzes the synthesis of GMP from XMP
C5F71_RS18375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5F71_RS18390	COG2188	Transcriptional regulator
C5F71_RS18400	COG1263	PTS System
C5F71_RS18400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5F71_RS18405	COG0366	Alpha amylase catalytic
C5F71_RS18415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5F71_RS18415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5F71_RS18425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C5F71_RS18430	COG0047	phosphoribosylformylglycinamidine synthase activity
C5F71_RS18430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5F71_RS18435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5F71_RS18445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5F71_RS18445	COG2190	(PTS) system
C5F71_RS18445	COG1263	PTS System
C5F71_RS18450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5F71_RS18450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5F71_RS18455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5F71_RS18460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5F71_RS18465	COG2188	Transcriptional regulator
C5F71_RS18480	COG0494	nUDIX hydrolase
C5F71_RS18505	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C5F71_RS18510	COG0477	Major facilitator Superfamily
C5F71_RS18515	COG4536	flavin adenine dinucleotide binding
C5F71_RS18525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5F71_RS18530	COG0228	four-way junction DNA binding
C5F71_RS18535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5F71_RS18540	COG0336	Belongs to the RNA methyltransferase TrmD family
C5F71_RS18545	COG0335	large ribosomal subunit rRNA binding
C5F71_RS18550	COG1607	acyl-coa hydrolase
C5F71_RS18555	COG4974	Belongs to the 'phage' integrase family
C5F71_RS18560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5F71_RS18575	COG2205	protein histidine kinase activity
C5F71_RS18575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS18585	COG2197	response regulator
C5F71_RS18600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F71_RS18610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5F71_RS18615	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS18635	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C5F71_RS18660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5F71_RS18660	COG0457	Tetratricopeptide repeat
C5F71_RS18675	COG2201	protein-glutamate methylesterase activity
C5F71_RS18680	COG3706	GGDEF domain
C5F71_RS18680	COG5001	Diguanylate cyclase
C5F71_RS18680	COG4251	negative regulation of phosphorylation
C5F71_RS18680	COG2203	Gaf domain
C5F71_RS18690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5F71_RS18710	COG1073	alpha beta
C5F71_RS18740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5F71_RS18745	COG0563	adenylate kinase activity
C5F71_RS18750	COG1214	PFAM Peptidase M22, glycoprotease
C5F71_RS18765	COG1801	Protein of unknown function DUF72
C5F71_RS18785	COG0742	ribosomal rna small subunit methyltransferase
C5F71_RS18795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS18800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS18815	COG2937	Belongs to the GPAT DAPAT family
C5F71_RS18830	COG2226	methyltransferase
C5F71_RS18835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5F71_RS18840	COG1215	transferase activity, transferring glycosyl groups
C5F71_RS18845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5F71_RS18850	COG2166	iron-sulfur cluster assembly
C5F71_RS18855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5F71_RS18860	COG2171	N-acyltransferase activity
C5F71_RS18865	COG1393	Belongs to the ArsC family
C5F71_RS18870	COG0025	NhaP-type Na H and K H
C5F71_RS18875	COG0436	Aminotransferase
C5F71_RS18880	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C5F71_RS18885	COG0024	Methionine aminopeptidase
C5F71_RS18890	COG0052	Belongs to the universal ribosomal protein uS2 family
C5F71_RS18895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5F71_RS18900	COG0528	UMP kinase activity
C5F71_RS18905	COG0233	cytoplasmic translational termination
C5F71_RS18910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5F71_RS18920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5F71_RS18930	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5F71_RS18940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F71_RS18945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5F71_RS18950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F71_RS18955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F71_RS18960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5F71_RS18965	COG0587	DNA-directed DNA polymerase activity
C5F71_RS18970	COG0825	malonyl-CoA metabolic process
C5F71_RS18975	COG0037	tRNA processing
C5F71_RS18980	COG0504	CTP synthase activity
C5F71_RS18985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C5F71_RS18990	COG0148	phosphopyruvate hydratase activity
C5F71_RS19000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5F71_RS19010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C5F71_RS19015	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5F71_RS19020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5F71_RS19025	COG0585	pseudouridine synthase activity
C5F71_RS19030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C5F71_RS19035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5F71_RS19050	COG1278	Cold shock
C5F71_RS19055	COG0717	Belongs to the dCTP deaminase family
C5F71_RS19090	COG2366	antibiotic biosynthetic process
C5F71_RS19095	COG0625	glutathione transferase activity
C5F71_RS19100	COG0653	protein targeting
C5F71_RS19110	COG3012	SEC-C Motif Domain Protein
C5F71_RS19140	COG1199	ATP-dependent helicase activity
C5F71_RS19160	COG0259	pyridoxamine-phosphate oxidase activity
C5F71_RS19190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5F71_RS19200	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C5F71_RS19220	COG0583	DNA-binding transcription factor activity
C5F71_RS19235	COG3220	belongs to the UPF0276 family
C5F71_RS19295	COG2271	Major facilitator Superfamily
C5F71_RS19300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5F71_RS19310	COG0306	phosphate transporter
C5F71_RS19320	COG1414	Transcriptional regulator
C5F71_RS19325	COG2814	Major facilitator Superfamily
C5F71_RS19330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5F71_RS19335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5F71_RS19340	COG0183	Belongs to the thiolase family
C5F71_RS19345	COG3485	protocatechuate 3,4-dioxygenase
C5F71_RS19350	COG3485	protocatechuate 3,4-dioxygenase
C5F71_RS19355	COG0477	Major facilitator Superfamily
C5F71_RS19365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F71_RS19370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F71_RS19400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS19405	COG1309	transcriptional regulator
C5F71_RS19410	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS19415	COG2814	Major facilitator Superfamily
C5F71_RS19455	COG1473	amidohydrolase
C5F71_RS19465	COG0154	amidase activity
C5F71_RS19480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F71_RS19490	COG1704	LemA family
C5F71_RS19510	COG0697	spore germination
C5F71_RS19515	COG1629	transport
C5F71_RS19525	COG1595	DNA-templated transcription, initiation
C5F71_RS19530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F71_RS19535	COG0235	Class ii aldolase
C5F71_RS19540	COG1396	sequence-specific DNA binding
C5F71_RS19550	COG1454	alcohol dehydrogenase
C5F71_RS19565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F71_RS19570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5F71_RS19575	COG2271	Major facilitator Superfamily
C5F71_RS19600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5F71_RS19665	COG4974	Belongs to the 'phage' integrase family
C5F71_RS19690	COG1204	response to ionizing radiation
C5F71_RS19785	COG2267	carboxylic ester hydrolase activity
C5F71_RS19815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5F71_RS19865	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C5F71_RS19895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5F71_RS19905	COG0425	Belongs to the sulfur carrier protein TusA family
C5F71_RS19910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5F71_RS19920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F71_RS19925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C5F71_RS19930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5F71_RS19935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5F71_RS19970	COG2814	Major facilitator Superfamily
C5F71_RS19975	COG1024	Enoyl-CoA hydratase
C5F71_RS19975	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F71_RS19980	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS20015	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F71_RS20020	COG0183	Belongs to the thiolase family
C5F71_RS20025	COG0183	Belongs to the thiolase family
C5F71_RS20030	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS20035	COG1024	Enoyl-CoA hydratase
C5F71_RS20040	COG0583	DNA-binding transcription factor activity
C5F71_RS20075	COG2807	transmembrane transport
C5F71_RS20085	COG2910	NAD(P)H-binding
C5F71_RS20095	COG0583	DNA-binding transcription factor activity
C5F71_RS20120	COG0174	glutamine synthetase
C5F71_RS20135	COG3100	YcgL domain-containing protein
C5F71_RS20140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5F71_RS20155	COG2983	Belongs to the UPF0260 family
C5F71_RS20190	COG1770	oligopeptidase
C5F71_RS20200	COG0121	glutamine amidotransferase
C5F71_RS20210	COG0583	DNA-binding transcription factor activity
C5F71_RS20215	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5F71_RS20220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5F71_RS20225	COG1984	allophanate hydrolase subunit 2
C5F71_RS20235	COG0542	response to heat
C5F71_RS20245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5F71_RS20275	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C5F71_RS20280	COG1643	Atp-dependent helicase
C5F71_RS20290	COG1595	DNA-templated transcription, initiation
C5F71_RS20310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5F71_RS20315	COG1132	(ABC) transporter
C5F71_RS20340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F71_RS20350	COG0668	transmembrane transport
C5F71_RS20355	COG0513	Belongs to the DEAD box helicase family
C5F71_RS20370	COG2132	Multicopper oxidase
C5F71_RS20405	COG2996	Protein conserved in bacteria
C5F71_RS20420	COG0583	DNA-binding transcription factor activity
C5F71_RS20425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5F71_RS20470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5F71_RS20475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5F71_RS20480	COG3956	TIGRFAM MazG family protein
C5F71_RS20485	COG3122	Protein conserved in bacteria
C5F71_RS20500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5F71_RS20505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5F71_RS20515	COG0628	permease
C5F71_RS20520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5F71_RS20525	COG0791	NLP P60 protein
C5F71_RS20530	COG0791	NLP P60 protein
C5F71_RS20545	COG1797	cobyrinic acid a,c-diamide synthase activity
C5F71_RS20550	COG0778	Nitroreductase
C5F71_RS20565	COG1492	cobalamin metabolic process
C5F71_RS20575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5F71_RS20585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C5F71_RS20590	COG1846	Transcriptional regulator
C5F71_RS20640	COG2205	protein histidine kinase activity
C5F71_RS20645	COG2832	Protein of unknown function (DUF454)
C5F71_RS20655	COG0514	ATP-dependent DNA helicase (RecQ)
C5F71_RS20665	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5F71_RS20700	COG2154	pterin-4-alpha-carbinolamine dehydratase
C5F71_RS20710	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C5F71_RS20715	COG4787	bacterial-type flagellum-dependent cell motility
C5F71_RS20725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C5F71_RS20730	COG1706	bacterial-type flagellum-dependent cell motility
C5F71_RS20765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5F71_RS20770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5F71_RS20775	COG1334	flagellar protein FlaG
C5F71_RS20810	COG1677	Flagellar hook-basal body complex protein FliE
C5F71_RS20905	COG1278	Cold shock
C5F71_RS20935	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C5F71_RS20940	COG0643	Histidine kinase
C5F71_RS20940	COG2198	Histidine kinase
C5F71_RS20940	COG0784	Response regulator, receiver
C5F71_RS20945	COG2201	protein-glutamate methylesterase activity
C5F71_RS20950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5F71_RS20965	COG1192	Involved in chromosome partitioning
C5F71_RS20975	COG0835	chemotaxis
C5F71_RS20985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5F71_RS20995	COG4133	protoheme IX ABC transporter activity
C5F71_RS21020	COG1138	Cytochrome C-type biogenesis protein
C5F71_RS21030	COG3088	subunit of a heme lyase
C5F71_RS21035	COG4235	cytochrome complex assembly
C5F71_RS21045	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C5F71_RS21050	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C5F71_RS21055	COG3639	organic phosphonate transmembrane transporter activity
C5F71_RS21060	COG2188	Transcriptional regulator
C5F71_RS21065	COG3624	Phosphonate C-P lyase system protein PhnG
C5F71_RS21075	COG3626	phosphonate metabolism
C5F71_RS21080	COG3627	carbon phosphorus lyase activity
C5F71_RS21085	COG4107	phosphonate C-P lyase system protein PhnK
C5F71_RS21090	COG4778	phosphonate C-P lyase system protein PhnL
C5F71_RS21095	COG3454	Phosphonate metabolism
C5F71_RS21100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C5F71_RS21105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5F71_RS21115	COG1598	PFAM Uncharacterised protein family UPF0150
C5F71_RS21120	COG2814	Major facilitator Superfamily
C5F71_RS21125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C5F71_RS21130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F71_RS21140	COG0469	pyruvate kinase activity
C5F71_RS21150	COG2084	Dehydrogenase
C5F71_RS21155	COG3622	Belongs to the hyi family
C5F71_RS21160	COG3960	tartronate-semialdehyde synthase activity
C5F71_RS21180	COG2354	Protein conserved in bacteria
C5F71_RS21190	COG2853	Lipoprotein
C5F71_RS21210	COG2113	Glycine betaine
C5F71_RS21215	COG3162	membrane
C5F71_RS21220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5F71_RS21230	COG2009	succinate dehydrogenase
C5F71_RS21235	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C5F71_RS21240	COG1053	succinate dehydrogenase
C5F71_RS21245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5F71_RS21260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5F71_RS21265	COG0045	succinate-CoA ligase (ADP-forming) activity
C5F71_RS21305	COG0326	Molecular chaperone. Has ATPase activity
C5F71_RS21315	COG1741	Belongs to the pirin family
C5F71_RS21345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5F71_RS21350	COG2205	protein histidine kinase activity
C5F71_RS21350	COG0784	Response regulator, receiver
C5F71_RS21350	COG5002	protein histidine kinase activity
C5F71_RS21365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5F71_RS21375	COG2062	phosphohistidine phosphatase, SixA
C5F71_RS21380	COG1022	Amp-dependent synthetase and ligase
C5F71_RS21405	COG0628	permease
C5F71_RS21420	COG0284	orotidine-5'-phosphate decarboxylase activity
C5F71_RS21425	COG2130	NADP-dependent
C5F71_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS21435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS21440	COG0840	transmembrane signaling receptor activity
C5F71_RS21475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5F71_RS21480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5F71_RS21500	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS21510	COG0625	glutathione transferase activity
C5F71_RS21515	COG1131	(ABC) transporter
C5F71_RS21520	COG0842	Transport permease protein
C5F71_RS21545	COG2076	Multidrug Resistance protein
C5F71_RS21550	COG0385	Bile acid
C5F71_RS21555	COG2974	May be involved in recombination
C5F71_RS21575	COG3712	iron ion homeostasis
C5F71_RS21580	COG1595	DNA-templated transcription, initiation
C5F71_RS21595	COG0745	RESPONSE REGULATOR receiver
C5F71_RS21600	COG2205	protein histidine kinase activity
C5F71_RS21605	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5F71_RS21610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5F71_RS21615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5F71_RS21630	COG2010	Cytochrome c
C5F71_RS21635	COG0545	Peptidyl-prolyl cis-trans isomerase
C5F71_RS21660	COG2200	EAL domain
C5F71_RS21670	COG0604	alcohol dehydrogenase
C5F71_RS21670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5F71_RS21670	COG3321	synthase
C5F71_RS21670	COG4221	oxidoreductase activity
C5F71_RS21675	COG0560	Phosphoserine phosphatase
C5F71_RS21680	COG3842	ATPase activity
C5F71_RS21690	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F71_RS21710	COG0668	transmembrane transport
C5F71_RS21715	COG1362	aminopeptidase activity
C5F71_RS21720	COG0564	pseudouridine synthase activity
C5F71_RS21725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C5F71_RS21730	COG2894	cell division
C5F71_RS21735	COG0850	regulation of cytokinetic process
C5F71_RS21740	COG1560	Kdo2-lipid A biosynthetic process
C5F71_RS21755	COG2233	PERMEase
C5F71_RS21765	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C5F71_RS21770	COG4266	Belongs to the allantoicase family
C5F71_RS21795	COG2252	PERMEase
C5F71_RS21805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS21810	COG0625	glutathione transferase activity
C5F71_RS21820	COG0302	gtp cyclohydrolase
C5F71_RS21825	COG2840	Smr protein MutS2
C5F71_RS21850	COG1073	alpha beta
C5F71_RS21855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5F71_RS21865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C5F71_RS21870	COG2197	response regulator
C5F71_RS21880	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS21985	COG4397	Mu-like prophage major head subunit gpT
C5F71_RS22000	COG5005	Phage virion morphogenesis
C5F71_RS22015	COG4383	Mu-like prophage protein gp29
C5F71_RS22020	COG4373	Mu-like prophage FluMu protein gp28
C5F71_RS22040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5F71_RS22150	COG1368	sulfuric ester hydrolase activity
C5F71_RS22170	COG3089	Belongs to the UPF0270 family
C5F71_RS22180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5F71_RS22180	COG0189	ligase activity
C5F71_RS22185	COG0367	asparagine synthase
C5F71_RS22195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS22195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C5F71_RS22205	COG2326	polyphosphate kinase activity
C5F71_RS22210	COG0183	Belongs to the thiolase family
C5F71_RS22215	COG0697	spore germination
C5F71_RS22220	COG0114	fumarate hydratase activity
C5F71_RS22230	COG0271	Belongs to the BolA IbaG family
C5F71_RS22240	COG1054	Belongs to the UPF0176 family
C5F71_RS22255	COG5001	Diguanylate cyclase
C5F71_RS22255	COG5002	protein histidine kinase activity
C5F71_RS22270	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS22275	COG0546	phosphoglycolate phosphatase activity
C5F71_RS22280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5F71_RS22285	COG0402	S-adenosylhomocysteine deaminase activity
C5F71_RS22290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5F71_RS22300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5F71_RS22310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F71_RS22315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5F71_RS22320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5F71_RS22330	COG0776	regulation of translation
C5F71_RS22345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C5F71_RS22365	COG2244	polysaccharide biosynthetic process
C5F71_RS22370	COG0463	Glycosyl transferase, family 2
C5F71_RS22395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5F71_RS22400	COG1086	Polysaccharide biosynthesis protein
C5F71_RS22410	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F71_RS22415	COG1555	photosystem II stabilization
C5F71_RS22440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5F71_RS22450	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5F71_RS22455	COG2205	protein histidine kinase activity
C5F71_RS22495	COG0084	hydrolase, TatD family'
C5F71_RS22500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C5F71_RS22525	COG1131	(ABC) transporter
C5F71_RS22535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F71_RS22540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C5F71_RS22545	COG4181	ATPase activity
C5F71_RS22585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5F71_RS22595	COG0589	response to stress
C5F71_RS22605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F71_RS22620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5F71_RS22625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5F71_RS22625	COG2755	lipolytic protein G-D-S-L family
C5F71_RS22630	COG1764	response to oxidative stress
C5F71_RS22635	COG1846	Transcriptional regulator
C5F71_RS22640	COG0583	DNA-binding transcription factor activity
C5F71_RS22650	COG0583	DNA-binding transcription factor activity
C5F71_RS22660	COG3214	Protein conserved in bacteria
C5F71_RS22665	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C5F71_RS22690	COG3384	dioxygenase
C5F71_RS22695	COG0500	methyltransferase
C5F71_RS22700	COG0501	Belongs to the peptidase M48B family
C5F71_RS22705	COG0436	Aminotransferase
C5F71_RS22710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5F71_RS22720	COG0386	Belongs to the glutathione peroxidase family
C5F71_RS22725	COG1846	Transcriptional regulator
C5F71_RS22730	COG0784	Response regulator, receiver
C5F71_RS22730	COG5002	protein histidine kinase activity
C5F71_RS22730	COG2205	protein histidine kinase activity
C5F71_RS22740	COG1956	GAF domain-containing protein
C5F71_RS22745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS22745	COG2205	protein histidine kinase activity
C5F71_RS22750	COG2197	response regulator
C5F71_RS22765	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C5F71_RS22785	COG0004	ammonium transporteR
C5F71_RS22805	COG0564	pseudouridine synthase activity
C5F71_RS22815	COG0746	molybdenum cofactor guanylyltransferase activity
C5F71_RS22820	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5F71_RS22825	COG0303	'Molybdopterin
C5F71_RS22830	COG1597	lipid kinase activity
C5F71_RS22835	COG2197	response regulator
C5F71_RS22840	COG3851	Histidine kinase
C5F71_RS22860	COG3123	guanosine phosphorylase activity
C5F71_RS22875	COG1024	Enoyl-CoA hydratase
C5F71_RS22880	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS22885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5F71_RS22940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5F71_RS22980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5F71_RS22985	COG1121	(ABC) transporter
C5F71_RS23025	COG3829	transcription factor binding
C5F71_RS23035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F71_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS23065	COG1309	transcriptional regulator
C5F71_RS23075	COG5006	permease, DMT superfamily
C5F71_RS23110	COG0768	penicillin binding
C5F71_RS23125	COG4774	siderophore transport
C5F71_RS23145	COG0473	3-isopropylmalate dehydrogenase activity
C5F71_RS23160	COG0417	DNA replication proofreading
C5F71_RS23175	COG1595	DNA-templated transcription, initiation
C5F71_RS23180	COG3712	iron ion homeostasis
C5F71_RS23195	COG0728	peptidoglycan biosynthetic process
C5F71_RS23245	COG0662	Cupin 2, conserved barrel domain protein
C5F71_RS23245	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C5F71_RS23250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5F71_RS23270	COG4977	sequence-specific DNA binding
C5F71_RS23275	COG3387	PFAM Glycoside hydrolase 15-related
C5F71_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS23285	COG2207	Transcriptional regulator
C5F71_RS23290	COG1538	Outer membrane efflux protein
C5F71_RS23305	COG1309	transcriptional regulator
C5F71_RS23360	COG0657	acetylesterase activity
C5F71_RS23405	COG1136	(ABC) transporter
C5F71_RS23405	COG0577	efflux transmembrane transporter activity
C5F71_RS23410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS23430	COG2197	response regulator
C5F71_RS23435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS23435	COG2205	protein histidine kinase activity
C5F71_RS23445	COG0656	L-ascorbic acid biosynthetic process
C5F71_RS23460	COG4206	TonB-dependent receptor
C5F71_RS23480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5F71_RS23480	COG0475	glutathione-regulated potassium exporter activity
C5F71_RS23520	COG0745	RESPONSE REGULATOR receiver
C5F71_RS23540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F71_RS23550	COG3718	enzyme involved in inositol metabolism
C5F71_RS23555	COG3962	Belongs to the TPP enzyme family
C5F71_RS23560	COG0673	inositol 2-dehydrogenase activity
C5F71_RS23565	COG0673	inositol 2-dehydrogenase activity
C5F71_RS23575	COG1129	ABC transporter
C5F71_RS23580	COG4211	Belongs to the binding-protein-dependent transport system permease family
C5F71_RS23590	COG0840	transmembrane signaling receptor activity
C5F71_RS23625	COG4774	siderophore transport
C5F71_RS23640	COG1320	monovalent cation:proton antiporter activity
C5F71_RS23645	COG2212	antiporter activity
C5F71_RS23655	COG0651	ATP synthesis coupled electron transport
C5F71_RS23660	COG1006	Multisubunit Na H antiporter MnhC subunit
C5F71_RS23665	COG2111	Na H antiporter
C5F71_RS23665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5F71_RS23690	COG0019	diaminopimelate decarboxylase activity
C5F71_RS23705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F71_RS23710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5F71_RS23720	COG1064	alcohol dehydrogenase
C5F71_RS23800	COG1522	sequence-specific DNA binding
C5F71_RS23815	COG0583	DNA-binding transcription factor activity
C5F71_RS23855	COG0154	amidase activity
C5F71_RS23860	COG2271	Major facilitator Superfamily
C5F71_RS23880	COG2814	Major facilitator Superfamily
C5F71_RS23920	COG0019	diaminopimelate decarboxylase activity
C5F71_RS23930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5F71_RS23945	COG0625	glutathione transferase activity
C5F71_RS23990	COG2267	carboxylic ester hydrolase activity
C5F71_RS24040	COG1999	signal sequence binding
C5F71_RS24075	COG2267	carboxylic ester hydrolase activity
C5F71_RS24080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS24100	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS24105	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS24115	COG0183	Belongs to the thiolase family
C5F71_RS24120	COG0318	PFAM AMP-dependent synthetase and ligase
C5F71_RS24125	COG0673	inositol 2-dehydrogenase activity
C5F71_RS24190	COG2706	6-phosphogluconolactonase activity
C5F71_RS24200	COG0625	glutathione transferase activity
C5F71_RS24210	COG0420	3'-5' exonuclease activity
C5F71_RS24260	COG0714	Associated with various cellular activities
C5F71_RS24275	COG2186	Transcriptional regulator
C5F71_RS24290	COG2818	Glycosylase
C5F71_RS24305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F71_RS24320	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS24330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F71_RS24350	COG0814	amino acid
C5F71_RS24365	COG0589	response to stress
C5F71_RS24375	COG0745	RESPONSE REGULATOR receiver
C5F71_RS24380	COG2205	protein histidine kinase activity
C5F71_RS24395	COG0348	domain, Protein
C5F71_RS24395	COG3901	Regulator of nitric oxide reductase transcription
C5F71_RS24415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C5F71_RS24425	COG2271	Major facilitator Superfamily
C5F71_RS24440	COG1192	Involved in chromosome partitioning
C5F71_RS24465	COG2851	Citrate transporter
C5F71_RS24470	COG1301	dicarboxylic acid transport
C5F71_RS24475	COG2828	Protein conserved in bacteria
C5F71_RS24480	COG0583	DNA-binding transcription factor activity
C5F71_RS24510	COG1280	lysine exporter protein (LysE YggA)
C5F71_RS24535	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS24540	COG0583	DNA-binding transcription factor activity
C5F71_RS24545	COG1090	epimerase
C5F71_RS24550	COG0789	Transcriptional regulator
C5F71_RS24570	COG0745	RESPONSE REGULATOR receiver
C5F71_RS24575	COG0642	Histidine kinase
C5F71_RS24610	COG1629	transport
C5F71_RS24610	COG4774	siderophore transport
C5F71_RS24625	COG1522	sequence-specific DNA binding
C5F71_RS24635	COG1113	amino acid transport
C5F71_RS24640	COG3706	GGDEF domain
C5F71_RS24645	COG0784	Response regulator, receiver
C5F71_RS24645	COG4191	Histidine kinase
C5F71_RS24655	COG0477	Major facilitator Superfamily
C5F71_RS24660	COG0579	oxidoreductase
C5F71_RS24665	COG2186	Transcriptional regulator
C5F71_RS24675	COG0583	DNA-binding transcription factor activity
C5F71_RS24690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5F71_RS24695	COG3012	SEC-C Motif Domain Protein
C5F71_RS24695	COG3318	Belongs to the UPF0149 family
C5F71_RS24705	COG1595	DNA-templated transcription, initiation
C5F71_RS24715	COG0730	response to heat
C5F71_RS24745	COG0604	alcohol dehydrogenase
C5F71_RS24755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5F71_RS24760	COG2010	Cytochrome c
C5F71_RS24765	COG3256	nitric oxide reductase
C5F71_RS24780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F71_RS24800	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C5F71_RS24805	COG3604	Transcriptional regulator
C5F71_RS24815	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5F71_RS24820	COG0303	'Molybdopterin
C5F71_RS24825	COG0826	peptidase U32
C5F71_RS24830	COG0826	peptidase U32
C5F71_RS24835	COG3154	lipid carrier protein
C5F71_RS24860	COG0697	spore germination
C5F71_RS24865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS24885	COG1595	DNA-templated transcription, initiation
C5F71_RS24895	COG0493	'glutamate synthase
C5F71_RS24915	COG3192	ethanolamine utilization protein
C5F71_RS24935	COG0625	glutathione transferase activity
C5F71_RS24945	COG1595	DNA-templated transcription, initiation
C5F71_RS24950	COG3712	iron ion homeostasis
C5F71_RS24955	COG4772	TonB-dependent receptor
C5F71_RS25020	COG2207	Transcriptional regulator
C5F71_RS25020	COG1917	Cupin 2, conserved barrel domain protein
C5F71_RS25035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5F71_RS25055	COG0488	(ABC) transporter
C5F71_RS25065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C5F71_RS25085	COG2169	Transcriptional regulator
C5F71_RS25085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5F71_RS25090	COG3145	DNA-N1-methyladenine dioxygenase activity
C5F71_RS25105	COG2863	cytochrome
C5F71_RS25110	COG3258	Cytochrome c
C5F71_RS25175	COG2200	EAL domain
C5F71_RS25180	COG0583	DNA-binding transcription factor activity
C5F71_RS25200	COG1522	sequence-specific DNA binding
C5F71_RS25210	COG0667	Aldo Keto reductase
C5F71_RS25220	COG4172	Belongs to the ABC transporter superfamily
C5F71_RS25225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5F71_RS25250	COG0747	negative chemotaxis
C5F71_RS25260	COG2271	Major facilitator Superfamily
C5F71_RS25265	COG3835	regulator
C5F71_RS25270	COG1929	Belongs to the glycerate kinase type-1 family
C5F71_RS25275	COG1247	-acetyltransferase
C5F71_RS25280	COG1794	racemase activity, acting on amino acids and derivatives
C5F71_RS25295	COG3278	Belongs to the heme-copper respiratory oxidase family
C5F71_RS25300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5F71_RS25315	COG0745	RESPONSE REGULATOR receiver
C5F71_RS25320	COG2205	protein histidine kinase activity
C5F71_RS25320	COG2198	Histidine kinase
C5F71_RS25320	COG0784	Response regulator, receiver
C5F71_RS25325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5F71_RS25335	COG2205	protein histidine kinase activity
C5F71_RS25335	COG0784	Response regulator, receiver
C5F71_RS25350	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C5F71_RS25360	COG3781	membrane
C5F71_RS25365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F71_RS25375	COG0183	Belongs to the thiolase family
C5F71_RS25380	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS25385	COG1024	Enoyl-CoA hydratase
C5F71_RS25400	COG2366	antibiotic biosynthetic process
C5F71_RS25415	COG0840	transmembrane signaling receptor activity
C5F71_RS25420	COG1968	undecaprenyl-diphosphatase activity
C5F71_RS25435	COG0583	DNA-binding transcription factor activity
C5F71_RS25440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F71_RS25455	COG0488	(ABC) transporter
C5F71_RS25490	COG2133	pyrroloquinoline quinone binding
C5F71_RS25505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F71_RS25515	COG2822	iron ion transport
C5F71_RS25525	COG2822	iron ion transport
C5F71_RS25530	COG0672	)-iron permease
C5F71_RS25535	COG2207	Transcriptional regulator
C5F71_RS25550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS25575	COG1280	lysine exporter protein (LysE YggA)
C5F71_RS25590	COG1971	Probably functions as a manganese efflux pump
C5F71_RS25595	COG0642	Histidine kinase
C5F71_RS25640	COG1595	DNA-templated transcription, initiation
C5F71_RS25645	COG0789	Transcriptional regulator
C5F71_RS25650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F71_RS25680	COG0154	amidase activity
C5F71_RS25685	COG0477	Major facilitator Superfamily
C5F71_RS25705	COG0300	oxidoreductase activity
C5F71_RS25725	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C5F71_RS25745	COG0583	DNA-binding transcription factor activity
C5F71_RS25755	COG4166	transmembrane transport
C5F71_RS25765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5F71_RS25770	COG4172	Belongs to the ABC transporter superfamily
C5F71_RS25785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5F71_RS25795	COG1309	transcriptional regulator
C5F71_RS25800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F71_RS25865	COG0583	DNA-binding transcription factor activity
C5F71_RS25875	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS25880	COG2207	Transcriptional regulator
C5F71_RS25900	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS25900	COG3321	synthase
C5F71_RS25900	COG0604	alcohol dehydrogenase
C5F71_RS25910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS25925	COG0210	DNA helicase
C5F71_RS25940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS25960	COG1113	amino acid transport
C5F71_RS26010	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C5F71_RS26025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F71_RS26025	COG1199	ATP-dependent helicase activity
C5F71_RS26030	COG2267	carboxylic ester hydrolase activity
C5F71_RS26045	COG2308	Evidence 4 Homologs of previously reported genes of
C5F71_RS26060	COG1522	sequence-specific DNA binding
C5F71_RS26070	COG0826	peptidase U32
C5F71_RS26085	COG1309	transcriptional regulator
C5F71_RS26095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5F71_RS26100	COG2197	response regulator
C5F71_RS26110	COG3121	Chaperone
C5F71_RS26115	COG3188	usher protein
C5F71_RS26120	COG3121	Chaperone
C5F71_RS26160	COG1131	(ABC) transporter
C5F71_RS26175	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS26190	COG2197	response regulator
C5F71_RS26195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS26195	COG2205	protein histidine kinase activity
C5F71_RS26205	COG0784	Response regulator, receiver
C5F71_RS26205	COG2205	protein histidine kinase activity
C5F71_RS26215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS26235	COG2831	hemolysin activation secretion protein
C5F71_RS26250	COG3539	Fimbrial protein
C5F71_RS26255	COG3121	Chaperone
C5F71_RS26260	COG3188	usher protein
C5F71_RS26275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5F71_RS26315	COG2186	Transcriptional regulator
C5F71_RS26320	COG2271	Major facilitator Superfamily
C5F71_RS26325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F71_RS26330	COG3395	kinase activity
C5F71_RS26335	COG0235	Class ii aldolase
C5F71_RS26340	COG3622	Belongs to the hyi family
C5F71_RS26350	COG3121	Chaperone
C5F71_RS26360	COG2205	protein histidine kinase activity
C5F71_RS26360	COG0784	Response regulator, receiver
C5F71_RS26365	COG5001	Diguanylate cyclase
C5F71_RS26365	COG3300	MHYT domain
C5F71_RS26375	COG2197	response regulator
C5F71_RS26380	COG3539	Fimbrial protein
C5F71_RS26385	COG3121	Chaperone
C5F71_RS26395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5F71_RS26405	COG0463	Glycosyl transferase, family 2
C5F71_RS26410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F71_RS26410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5F71_RS26415	COG0726	polysaccharide deacetylase
C5F71_RS26420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5F71_RS26425	COG2076	Multidrug Resistance protein
C5F71_RS26430	COG2076	Multidrug Resistance protein
C5F71_RS26450	COG1024	Enoyl-CoA hydratase
C5F71_RS26455	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS26475	COG1238	metal cluster binding
C5F71_RS26480	COG0596	Alpha beta hydrolase
C5F71_RS26485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5F71_RS26490	COG0297	glycogen (starch) synthase activity
C5F71_RS26495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5F71_RS26500	COG1640	4-alpha-glucanotransferase
C5F71_RS26555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5F71_RS26570	COG1285	pathogenesis
C5F71_RS26585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F71_RS26595	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS26605	COG1538	Outer membrane efflux protein
C5F71_RS26615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS26645	COG1175	transmembrane transport
C5F71_RS26660	COG0246	Mannitol dehydrogenase
C5F71_RS26665	COG1070	Carbohydrate kinase
C5F71_RS26690	COG4574	serine-type endopeptidase inhibitor activity
C5F71_RS26695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5F71_RS26705	COG0024	Methionine aminopeptidase
C5F71_RS26710	COG0189	ligase activity
C5F71_RS26720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F71_RS26730	COG2816	NAD+ diphosphatase activity
C5F71_RS26735	COG1024	Enoyl-CoA hydratase
C5F71_RS26740	COG2205	protein histidine kinase activity
C5F71_RS26745	COG0745	RESPONSE REGULATOR receiver
C5F71_RS26750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS26755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F71_RS26780	COG1609	Transcriptional regulator
C5F71_RS26790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F71_RS26810	COG2233	PERMEase
C5F71_RS26885	COG2204	response regulator
C5F71_RS26895	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5F71_RS26900	COG0561	phosphatase activity
C5F71_RS26905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5F71_RS26910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5F71_RS26915	COG2194	sulfuric ester hydrolase activity
C5F71_RS26930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5F71_RS26935	COG0308	aminopeptidase N
C5F71_RS26945	COG3139	Protein of unknown function (DUF1315)
C5F71_RS26955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5F71_RS26960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5F71_RS27025	COG0316	Belongs to the HesB IscA family
C5F71_RS27025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5F71_RS27050	COG1879	ABC-type sugar transport system periplasmic component
C5F71_RS27065	COG0431	NADPH-dependent FMN reductase
C5F71_RS27090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F71_RS27100	COG0328	RNA-DNA hybrid ribonuclease activity
C5F71_RS27110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5F71_RS27115	COG0741	lytic transglycosylase activity
C5F71_RS27115	COG1388	LysM domain
C5F71_RS27120	COG4166	transmembrane transport
C5F71_RS27125	COG4166	transmembrane transport
C5F71_RS27130	COG4174	ABC transporter (Permease)
C5F71_RS27135	COG4239	(ABC) transporter, permease
C5F71_RS27140	COG4172	Belongs to the ABC transporter superfamily
C5F71_RS27145	COG1595	DNA-templated transcription, initiation
C5F71_RS27170	COG0494	nUDIX hydrolase
C5F71_RS27235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5F71_RS27235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5F71_RS27255	COG2181	nitrate reductase activity
C5F71_RS27260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C5F71_RS27265	COG1140	nitrate reductase beta subunit
C5F71_RS27270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C5F71_RS27275	COG2223	nitrite transmembrane transporter activity
C5F71_RS27285	COG3850	Histidine kinase
C5F71_RS27290	COG2197	response regulator
C5F71_RS27295	COG0697	spore germination
C5F71_RS27300	COG0583	DNA-binding transcription factor activity
C5F71_RS27310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5F71_RS27325	COG3712	iron ion homeostasis
C5F71_RS27330	COG1595	DNA-templated transcription, initiation
C5F71_RS27340	COG2271	Major facilitator Superfamily
C5F71_RS27345	COG4948	Mandelate Racemase Muconate Lactonizing
C5F71_RS27355	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS27365	COG3254	rhamnose metabolic process
C5F71_RS27375	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS27390	COG1845	cytochrome c oxidase, subunit III
C5F71_RS27395	COG0714	Associated with various cellular activities
C5F71_RS27410	COG2010	Cytochrome c
C5F71_RS27415	COG3391	amine dehydrogenase activity
C5F71_RS27445	COG0535	radical SAM domain protein
C5F71_RS27450	COG1648	precorrin-2 dehydrogenase activity
C5F71_RS27450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5F71_RS27475	COG0515	serine threonine protein kinase
C5F71_RS27475	COG2815	serine threonine protein kinase
C5F71_RS27480	COG0631	protein serine/threonine phosphatase activity
C5F71_RS27515	COG2204	response regulator
C5F71_RS27560	COG0656	L-ascorbic acid biosynthetic process
C5F71_RS27580	COG0277	FAD linked oxidase domain protein
C5F71_RS27620	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS27635	COG0577	efflux transmembrane transporter activity
C5F71_RS27635	COG1136	(ABC) transporter
C5F71_RS27640	COG0577	efflux transmembrane transporter activity
C5F71_RS27650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS27680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F71_RS27700	COG0778	Nitroreductase
C5F71_RS27705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5F71_RS27710	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS27715	COG1902	pentaerythritol trinitrate reductase activity
C5F71_RS27720	COG0640	Transcriptional regulator
C5F71_RS27740	COG5001	Diguanylate cyclase
C5F71_RS27740	COG3300	MHYT domain
C5F71_RS27775	COG2165	general secretion pathway protein
C5F71_RS27785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5F71_RS27825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5F71_RS27830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5F71_RS27845	COG4771	TonB-dependent receptor
C5F71_RS27850	COG4771	TonB-dependent receptor
C5F71_RS27870	COG1132	(ABC) transporter
C5F71_RS27870	COG2375	cellular response to nickel ion
C5F71_RS27890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5F71_RS27900	COG4335	DNA alkylation repair
C5F71_RS27910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F71_RS27915	COG0154	amidase activity
C5F71_RS27920	COG0475	glutathione-regulated potassium exporter activity
C5F71_RS27925	COG1335	isochorismatase
C5F71_RS27930	COG1335	isochorismatase
C5F71_RS27935	COG0583	DNA-binding transcription factor activity
C5F71_RS27960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F71_RS27975	COG0583	DNA-binding transcription factor activity
C5F71_RS27980	COG2814	Major facilitator Superfamily
C5F71_RS28000	COG3264	Mechanosensitive ion channel
C5F71_RS28000	COG1511	domain protein
C5F71_RS28005	COG1024	Enoyl-CoA hydratase
C5F71_RS28005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5F71_RS28015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F71_RS28030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5F71_RS28040	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS28050	COG4638	Rieske (2fe-2S)
C5F71_RS28065	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS28070	COG0154	amidase activity
C5F71_RS28080	COG1846	Transcriptional regulator
C5F71_RS28150	COG1960	acyl-CoA dehydrogenase activity
C5F71_RS28155	COG0183	Belongs to the thiolase family
C5F71_RS28160	COG1022	Amp-dependent synthetase and ligase
C5F71_RS28160	COG3320	Male sterility
C5F71_RS28165	COG1012	belongs to the aldehyde dehydrogenase family
C5F71_RS28170	COG1024	Enoyl-CoA hydratase
C5F71_RS28180	COG0129	dihydroxy-acid dehydratase activity
C5F71_RS28195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F71_RS28200	COG2814	Major facilitator Superfamily
C5F71_RS28210	COG2814	Major facilitator Superfamily
C5F71_RS28240	COG1733	regulation of RNA biosynthetic process
C5F71_RS28265	COG2010	Cytochrome c
C5F71_RS28295	COG2197	response regulator
C5F71_RS28300	COG2205	protein histidine kinase activity
C5F71_RS28300	COG0784	Response regulator, receiver
C5F71_RS28330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5F71_RS28335	COG0840	transmembrane signaling receptor activity
C5F71_RS28345	COG0251	oxidation-reduction process
C5F71_RS28350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F71_RS28355	COG2188	Transcriptional regulator
C5F71_RS28360	COG2986	histidine ammonia-lyase
C5F71_RS28365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5F71_RS28385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F71_RS28420	COG1028	Short-chain dehydrogenase reductase Sdr
C5F71_RS28425	COG0583	DNA-binding transcription factor activity
C5F71_RS28435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F71_RS28450	COG4774	siderophore transport
C5F71_RS28480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5F71_RS28485	COG1335	isochorismatase
C5F71_RS28505	COG4890	Cyd operon protein YbgT
C5F71_RS28510	COG1294	oxidase, subunit
C5F71_RS28565	COG4774	siderophore transport
C5F71_RS28590	COG0583	DNA-binding transcription factor activity
C5F71_RS28595	COG0436	Aminotransferase
C5F71_RS28630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F71_RS28650	COG2894	cell division
C5F71_RS28690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5F71_RS28715	COG2003	Belongs to the UPF0758 family