locus-tag	class	description
C5F70_RS00060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C5F70_RS00065	COG0477	Major facilitator Superfamily
C5F70_RS00070	COG4536	flavin adenine dinucleotide binding
C5F70_RS00080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5F70_RS00085	COG0228	four-way junction DNA binding
C5F70_RS00090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5F70_RS00095	COG0336	Belongs to the RNA methyltransferase TrmD family
C5F70_RS00100	COG0335	large ribosomal subunit rRNA binding
C5F70_RS00105	COG4974	Belongs to the 'phage' integrase family
C5F70_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F70_RS00170	COG0842	Transport permease protein
C5F70_RS00175	COG1129	ABC transporter
C5F70_RS00175	COG0842	Transport permease protein
C5F70_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS00190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5F70_RS00200	COG0442	prolyl-tRNA aminoacylation
C5F70_RS00210	COG2211	Major facilitator Superfamily
C5F70_RS00235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5F70_RS00240	COG0459	protein refolding
C5F70_RS00250	COG1368	sulfuric ester hydrolase activity
C5F70_RS00270	COG3642	lipopolysaccharide core region biosynthetic process
C5F70_RS00300	COG0840	transmembrane signaling receptor activity
C5F70_RS00305	COG2832	Protein of unknown function (DUF454)
C5F70_RS00320	COG3712	iron ion homeostasis
C5F70_RS00325	COG1595	DNA-templated transcription, initiation
C5F70_RS00355	COG2207	Transcriptional regulator
C5F70_RS00375	COG0477	Major facilitator Superfamily
C5F70_RS00385	COG4191	Histidine kinase
C5F70_RS00395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F70_RS00400	COG0469	pyruvate kinase activity
C5F70_RS00420	COG0714	Associated with various cellular activities
C5F70_RS00455	COG2925	Exonuclease
C5F70_RS00465	COG0788	formyltetrahydrofolate deformylase activity
C5F70_RS00480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5F70_RS00480	COG0438	transferase activity, transferring glycosyl groups
C5F70_RS00490	COG0433	COG0433 Predicted ATPase
C5F70_RS00500	COG0653	protein targeting
C5F70_RS00505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5F70_RS00515	COG2096	Adenosyltransferase
C5F70_RS00520	COG4191	Histidine kinase
C5F70_RS00520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS00530	COG1666	GTP binding
C5F70_RS00535	COG0668	transmembrane transport
C5F70_RS00550	COG2900	Belongs to the SlyX family
C5F70_RS00560	COG0783	Belongs to the Dps family
C5F70_RS00575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5F70_RS00580	COG0217	transcriptional regulatory protein
C5F70_RS00585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5F70_RS00590	COG0632	four-way junction helicase activity
C5F70_RS00595	COG2255	four-way junction helicase activity
C5F70_RS00600	COG0824	Thioesterase
C5F70_RS00620	COG0823	Involved in the tonB-independent uptake of proteins
C5F70_RS00625	COG2885	chlorophyll binding
C5F70_RS00630	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5F70_RS00635	COG0602	queuosine metabolic process
C5F70_RS00640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5F70_RS00660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5F70_RS00670	COG1278	Cold shock
C5F70_RS00675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F70_RS00680	COG1760	l-serine dehydratase
C5F70_RS00685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5F70_RS00685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5F70_RS00690	COG0509	glycine decarboxylation via glycine cleavage system
C5F70_RS00735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F70_RS00740	COG0642	Histidine kinase
C5F70_RS00750	COG0745	RESPONSE REGULATOR receiver
C5F70_RS00760	COG2350	Protein conserved in bacteria
C5F70_RS00765	COG2917	probably involved in intracellular septation
C5F70_RS00775	COG0009	L-threonylcarbamoyladenylate synthase
C5F70_RS00785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5F70_RS00800	COG1113	amino acid transport
C5F70_RS00830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5F70_RS00855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5F70_RS00865	COG0583	DNA-binding transcription factor activity
C5F70_RS00870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F70_RS00885	COG1653	transport
C5F70_RS00890	COG1175	transmembrane transport
C5F70_RS00900	COG3842	ATPase activity
C5F70_RS00910	COG0676	glucose-6-phosphate 1-epimerase activity
C5F70_RS00915	COG1737	Transcriptional regulator
C5F70_RS00930	COG0800	Aldolase
C5F70_RS00935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5F70_RS00940	COG3530	Putative quorum-sensing-regulated virulence factor
C5F70_RS00950	COG2030	dehydratase
C5F70_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS00965	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS00975	COG3237	CsbD-like
C5F70_RS00980	COG1295	ribonuclease BN
C5F70_RS00985	COG0242	peptide deformylase activity
C5F70_RS01015	COG1609	Transcriptional regulator
C5F70_RS01020	COG3265	gluconokinase activity
C5F70_RS01030	COG0436	Aminotransferase
C5F70_RS01050	COG3795	YCII-related domain
C5F70_RS01055	COG4941	Belongs to the sigma-70 factor family
C5F70_RS01060	COG0583	DNA-binding transcription factor activity
C5F70_RS01070	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS01075	COG0583	DNA-binding transcription factor activity
C5F70_RS01085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5F70_RS01095	COG1984	allophanate hydrolase subunit 2
C5F70_RS01100	COG0306	phosphate transporter
C5F70_RS01120	COG0584	glycerophosphoryl diester phosphodiesterase
C5F70_RS01130	COG2329	Antibiotic biosynthesis monooxygenase
C5F70_RS01135	COG0504	CTP synthase activity
C5F70_RS01150	COG3706	GGDEF domain
C5F70_RS01195	COG0583	DNA-binding transcription factor activity
C5F70_RS01215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5F70_RS01260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F70_RS01275	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS01280	COG3724	N-succinylarginine dihydrolase activity
C5F70_RS01290	COG2988	succinylglutamate desuccinylase activity
C5F70_RS01295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5F70_RS01300	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C5F70_RS01305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5F70_RS01310	COG0527	aspartate kinase activity
C5F70_RS01315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5F70_RS01335	COG2239	Acts as a magnesium transporter
C5F70_RS01410	COG0640	Transcriptional regulator
C5F70_RS01430	COG4993	Dehydrogenase
C5F70_RS01435	COG0477	Major facilitator Superfamily
C5F70_RS01440	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C5F70_RS01460	COG0835	chemotaxis
C5F70_RS01460	COG0784	Response regulator, receiver
C5F70_RS01465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5F70_RS01470	COG1815	bacterial-type flagellum-dependent cell motility
C5F70_RS01505	COG0745	RESPONSE REGULATOR receiver
C5F70_RS01510	COG2205	protein histidine kinase activity
C5F70_RS01515	COG2977	Belongs to the P-Pant transferase superfamily
C5F70_RS01535	COG4977	sequence-specific DNA binding
C5F70_RS01535	COG1917	Cupin 2, conserved barrel domain protein
C5F70_RS01540	COG1301	dicarboxylic acid transport
C5F70_RS01555	COG3608	succinylglutamate desuccinylase aspartoacylase
C5F70_RS01555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5F70_RS01570	COG1530	ribonuclease E activity
C5F70_RS01585	COG0546	phosphoglycolate phosphatase activity
C5F70_RS01590	COG0616	signal peptide processing
C5F70_RS01590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5F70_RS01595	COG0424	maF-like protein
C5F70_RS01605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5F70_RS01610	COG0416	fatty acid biosynthetic process
C5F70_RS01625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5F70_RS01630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F70_RS01640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5F70_RS01645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5F70_RS01655	COG0084	hydrolase, TatD family'
C5F70_RS01665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5F70_RS01680	COG2188	Transcriptional regulator
C5F70_RS01685	COG1397	ADP-ribosylglycohydrolase
C5F70_RS01695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F70_RS01715	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS01720	COG1879	ABC-type sugar transport system periplasmic component
C5F70_RS01725	COG1129	ABC transporter
C5F70_RS01730	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F70_RS01735	COG1414	Transcriptional regulator
C5F70_RS01740	COG1064	alcohol dehydrogenase
C5F70_RS01745	COG2207	Transcriptional regulator
C5F70_RS01775	COG3047	cAMP biosynthetic process
C5F70_RS01775	COG2885	chlorophyll binding
C5F70_RS01780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS01810	COG2308	Evidence 4 Homologs of previously reported genes of
C5F70_RS01820	COG1305	Transglutaminase-like
C5F70_RS01830	COG0183	Belongs to the thiolase family
C5F70_RS01835	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F70_RS01835	COG1024	Enoyl-CoA hydratase
C5F70_RS01840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5F70_RS01840	COG0519	Catalyzes the synthesis of GMP from XMP
C5F70_RS01845	COG0598	Magnesium transport protein CorA
C5F70_RS01855	COG1024	Enoyl-CoA hydratase
C5F70_RS01855	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F70_RS01915	COG0583	DNA-binding transcription factor activity
C5F70_RS01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5F70_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS01935	COG0583	DNA-binding transcription factor activity
C5F70_RS01945	COG1953	Uracil, thiamine, allantoin
C5F70_RS01955	COG0560	Phosphoserine phosphatase
C5F70_RS01975	COG0189	ligase activity
C5F70_RS01985	COG4067	protein conserved in archaea
C5F70_RS01985	COG0189	ligase activity
C5F70_RS01990	COG1802	Transcriptional regulator
C5F70_RS02000	COG0372	Belongs to the citrate synthase family
C5F70_RS02005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5F70_RS02025	COG2079	MmgE PrpD family protein
C5F70_RS02035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5F70_RS02040	COG1045	serine acetyltransferase
C5F70_RS02045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5F70_RS02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS02065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C5F70_RS02080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5F70_RS02105	COG3047	cAMP biosynthetic process
C5F70_RS02105	COG2885	chlorophyll binding
C5F70_RS02110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5F70_RS02120	COG2223	nitrite transmembrane transporter activity
C5F70_RS02125	COG3707	response regulator
C5F70_RS02130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5F70_RS02140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5F70_RS02155	COG0167	dihydroorotate dehydrogenase activity
C5F70_RS02160	COG3130	regulation of translation
C5F70_RS02165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5F70_RS02165	COG0116	Belongs to the methyltransferase superfamily
C5F70_RS02180	COG3171	Protein conserved in bacteria
C5F70_RS02185	COG3135	benzoate transporter
C5F70_RS02190	COG1802	Transcriptional regulator
C5F70_RS02195	COG0402	S-adenosylhomocysteine deaminase activity
C5F70_RS02205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5F70_RS02225	COG3115	cell septum assembly
C5F70_RS02230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5F70_RS02255	COG0583	DNA-binding transcription factor activity
C5F70_RS02275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5F70_RS02280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5F70_RS02285	COG2130	NADP-dependent
C5F70_RS02290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5F70_RS02295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5F70_RS02300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F70_RS02325	COG2217	Heavy metal translocating P-type atpase
C5F70_RS02335	COG0348	domain, Protein
C5F70_RS02340	COG2010	Cytochrome c
C5F70_RS02355	COG3278	Belongs to the heme-copper respiratory oxidase family
C5F70_RS02360	COG2010	Cytochrome c
C5F70_RS02375	COG3278	Belongs to the heme-copper respiratory oxidase family
C5F70_RS02385	COG0840	transmembrane signaling receptor activity
C5F70_RS02440	COG1216	Glycosyl transferase, family 2
C5F70_RS02440	COG0438	transferase activity, transferring glycosyl groups
C5F70_RS02455	COG0463	Glycosyl transferase, family 2
C5F70_RS02470	COG3436	PFAM IS66 Orf2 family protein
C5F70_RS02475	COG4372	Transposase
C5F70_RS02505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C5F70_RS02510	COG1643	Atp-dependent helicase
C5F70_RS02520	COG1595	DNA-templated transcription, initiation
C5F70_RS02530	COG2188	Transcriptional regulator
C5F70_RS02540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5F70_RS02545	COG1132	(ABC) transporter
C5F70_RS02570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F70_RS02610	COG0668	transmembrane transport
C5F70_RS02615	COG0513	Belongs to the DEAD box helicase family
C5F70_RS02640	COG2996	Protein conserved in bacteria
C5F70_RS02645	COG1953	Uracil, thiamine, allantoin
C5F70_RS02655	COG0583	DNA-binding transcription factor activity
C5F70_RS02660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5F70_RS02700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5F70_RS02705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5F70_RS02715	COG3956	TIGRFAM MazG family protein
C5F70_RS02725	COG3956	TIGRFAM MazG family protein
C5F70_RS02730	COG3956	TIGRFAM MazG family protein
C5F70_RS02735	COG3122	Protein conserved in bacteria
C5F70_RS02745	COG2814	Major facilitator Superfamily
C5F70_RS02750	COG4264	IucA IucC family
C5F70_RS02770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5F70_RS02775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5F70_RS02785	COG0628	permease
C5F70_RS02790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5F70_RS02795	COG0791	NLP P60 protein
C5F70_RS02800	COG0791	NLP P60 protein
C5F70_RS02815	COG1797	cobyrinic acid a,c-diamide synthase activity
C5F70_RS02820	COG0778	Nitroreductase
C5F70_RS02825	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C5F70_RS02835	COG1492	cobalamin metabolic process
C5F70_RS02845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5F70_RS02855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C5F70_RS02860	COG1846	Transcriptional regulator
C5F70_RS02910	COG2205	protein histidine kinase activity
C5F70_RS02910	COG0784	Response regulator, receiver
C5F70_RS02915	COG2832	Protein of unknown function (DUF454)
C5F70_RS02925	COG0514	ATP-dependent DNA helicase (RecQ)
C5F70_RS02930	COG1846	Transcriptional regulator
C5F70_RS02935	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5F70_RS02955	COG2207	Transcriptional regulator
C5F70_RS02970	COG2154	pterin-4-alpha-carbinolamine dehydratase
C5F70_RS02990	COG4787	bacterial-type flagellum-dependent cell motility
C5F70_RS03000	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C5F70_RS03005	COG1706	bacterial-type flagellum-dependent cell motility
C5F70_RS03015	COG1256	bacterial-type flagellum assembly
C5F70_RS03015	COG4786	Flagellar basal body rod
C5F70_RS03025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5F70_RS03030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5F70_RS03040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5F70_RS03070	COG1677	Flagellar hook-basal body complex protein FliE
C5F70_RS03155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5F70_RS03165	COG1278	Cold shock
C5F70_RS03205	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C5F70_RS03210	COG0643	Histidine kinase
C5F70_RS03210	COG0784	Response regulator, receiver
C5F70_RS03210	COG2198	Histidine kinase
C5F70_RS03215	COG2201	protein-glutamate methylesterase activity
C5F70_RS03220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5F70_RS03225	COG1360	Flagellar Motor Protein
C5F70_RS03230	COG1192	Involved in chromosome partitioning
C5F70_RS03240	COG0835	chemotaxis
C5F70_RS03250	COG1597	lipid kinase activity
C5F70_RS03255	COG2197	response regulator
C5F70_RS03260	COG3851	Histidine kinase
C5F70_RS03275	COG3217	Mosc domain protein beta barrel domain protein
C5F70_RS03275	COG0633	Ferredoxin
C5F70_RS03280	COG3123	guanosine phosphorylase activity
C5F70_RS03300	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS03310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5F70_RS03350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5F70_RS03365	COG0642	Histidine kinase
C5F70_RS03370	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5F70_RS03385	COG0668	transmembrane transport
C5F70_RS03390	COG1362	aminopeptidase activity
C5F70_RS03395	COG0564	pseudouridine synthase activity
C5F70_RS03400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C5F70_RS03405	COG2894	cell division
C5F70_RS03410	COG0850	regulation of cytokinetic process
C5F70_RS03415	COG1560	Kdo2-lipid A biosynthetic process
C5F70_RS03435	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C5F70_RS03440	COG4266	Belongs to the allantoicase family
C5F70_RS03500	COG2252	PERMEase
C5F70_RS03510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS03515	COG0625	glutathione transferase activity
C5F70_RS03520	COG0583	DNA-binding transcription factor activity
C5F70_RS03525	COG2851	Citrate transporter
C5F70_RS03550	COG0302	gtp cyclohydrolase
C5F70_RS03555	COG2840	Smr protein MutS2
C5F70_RS03580	COG1073	alpha beta
C5F70_RS03585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5F70_RS03595	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C5F70_RS03600	COG2197	response regulator
C5F70_RS03610	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS03630	COG1368	sulfuric ester hydrolase activity
C5F70_RS03650	COG3089	Belongs to the UPF0270 family
C5F70_RS03655	COG1363	Peptidase, m42
C5F70_RS03660	COG0189	ligase activity
C5F70_RS03660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5F70_RS03665	COG0367	asparagine synthase
C5F70_RS03670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS03670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C5F70_RS03675	COG2326	polyphosphate kinase activity
C5F70_RS03680	COG0183	Belongs to the thiolase family
C5F70_RS03685	COG0697	spore germination
C5F70_RS03695	COG0114	fumarate hydratase activity
C5F70_RS03705	COG0271	Belongs to the BolA IbaG family
C5F70_RS03710	COG1054	Belongs to the UPF0176 family
C5F70_RS03725	COG5001	Diguanylate cyclase
C5F70_RS03725	COG5002	protein histidine kinase activity
C5F70_RS03740	COG1304	FMN binding
C5F70_RS03745	COG0583	DNA-binding transcription factor activity
C5F70_RS03755	COG1192	Involved in chromosome partitioning
C5F70_RS03790	COG4221	oxidoreductase activity
C5F70_RS03800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS03810	COG0659	secondary active sulfate transmembrane transporter activity
C5F70_RS03820	COG0281	malic enzyme
C5F70_RS03825	COG0473	3-isopropylmalate dehydrogenase activity
C5F70_RS03845	COG3539	Fimbrial protein
C5F70_RS03850	COG3121	Chaperone
C5F70_RS03870	COG1230	cation diffusion facilitator family transporter
C5F70_RS03880	COG2391	methyltransferase activity
C5F70_RS03890	COG0840	transmembrane signaling receptor activity
C5F70_RS03915	COG0583	DNA-binding transcription factor activity
C5F70_RS03920	COG1126	abc transporter atp-binding protein
C5F70_RS03925	COG5285	phytanoyl-CoA dioxygenase
C5F70_RS03950	COG2384	SAM-dependent methyltransferase
C5F70_RS03955	COG0840	transmembrane signaling receptor activity
C5F70_RS04000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5F70_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5F70_RS04010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5F70_RS04015	COG3591	Belongs to the peptidase S1B family
C5F70_RS04015	COG1864	DNA RNA non-specific endonuclease
C5F70_RS04030	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS04035	COG0583	DNA-binding transcription factor activity
C5F70_RS04050	COG0556	nucleotide-excision repair
C5F70_RS04055	COG0556	nucleotide-excision repair
C5F70_RS04060	COG0556	nucleotide-excision repair
C5F70_RS04065	COG0556	nucleotide-excision repair
C5F70_RS04070	COG0556	nucleotide-excision repair
C5F70_RS04075	COG0556	nucleotide-excision repair
C5F70_RS04080	COG0556	nucleotide-excision repair
C5F70_RS04085	COG0556	nucleotide-excision repair
C5F70_RS04100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5F70_RS04130	COG0596	Alpha beta hydrolase
C5F70_RS04140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5F70_RS04170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5F70_RS04175	COG0066	3-isopropylmalate dehydratase activity
C5F70_RS04180	COG2226	methyltransferase
C5F70_RS04185	COG0473	3-isopropylmalate dehydrogenase activity
C5F70_RS04210	COG0135	phosphoribosylanthranilate isomerase activity
C5F70_RS04215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5F70_RS04220	COG0285	dihydrofolate synthase activity
C5F70_RS04225	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5F70_RS04230	COG1286	toxin biosynthetic process
C5F70_RS04265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS04275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5F70_RS04290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5F70_RS04315	COG1879	ABC-type sugar transport system periplasmic component
C5F70_RS04320	COG1129	ABC transporter
C5F70_RS04325	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F70_RS04330	COG1609	Transcriptional regulator
C5F70_RS04335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F70_RS04340	COG1869	D-ribose catabolic process
C5F70_RS04365	COG1278	Cold shock
C5F70_RS04375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5F70_RS04380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5F70_RS04385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5F70_RS04390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5F70_RS04395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5F70_RS04400	COG0072	phenylalanine-tRNA ligase activity
C5F70_RS04405	COG0776	regulation of translation
C5F70_RS04420	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C5F70_RS04440	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5F70_RS04470	COG3311	Transcriptional regulator
C5F70_RS04505	COG0488	(ABC) transporter
C5F70_RS04515	COG2814	Major facilitator Superfamily
C5F70_RS04520	COG0583	DNA-binding transcription factor activity
C5F70_RS04535	COG2010	Cytochrome c
C5F70_RS04535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5F70_RS04540	COG2080	2 iron, 2 sulfur cluster binding
C5F70_RS04545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5F70_RS04545	COG2010	Cytochrome c
C5F70_RS04550	COG0583	DNA-binding transcription factor activity
C5F70_RS04560	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS04580	COG0583	DNA-binding transcription factor activity
C5F70_RS04595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5F70_RS04600	COG0581	inorganic phosphate transmembrane transporter activity
C5F70_RS04605	COG0573	inorganic phosphate transmembrane transporter activity
C5F70_RS04610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5F70_RS04615	COG0840	transmembrane signaling receptor activity
C5F70_RS04650	COG1294	oxidase, subunit
C5F70_RS04665	COG4774	siderophore transport
C5F70_RS04670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5F70_RS04675	COG1459	type II secretion system
C5F70_RS04680	COG2165	general secretion pathway protein
C5F70_RS04700	COG3156	type II secretion system protein K
C5F70_RS04720	COG1450	Type ii and iii secretion system protein
C5F70_RS04750	COG1122	ATPase activity
C5F70_RS04755	COG0390	transport system, permease component
C5F70_RS04760	COG0625	glutathione transferase activity
C5F70_RS04770	COG0583	DNA-binding transcription factor activity
C5F70_RS04800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5F70_RS04915	COG2186	Transcriptional regulator
C5F70_RS04930	COG0577	efflux transmembrane transporter activity
C5F70_RS04930	COG1136	(ABC) transporter
C5F70_RS04935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS04970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5F70_RS04975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5F70_RS04985	COG0022	dehydrogenase e1 component
C5F70_RS04990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5F70_RS04995	COG1522	sequence-specific DNA binding
C5F70_RS05020	COG2205	protein histidine kinase activity
C5F70_RS05020	COG0784	Response regulator, receiver
C5F70_RS05040	COG1131	(ABC) transporter
C5F70_RS05055	COG4585	Histidine kinase
C5F70_RS05095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5F70_RS05125	COG5002	protein histidine kinase activity
C5F70_RS05130	COG0471	metal ion transport
C5F70_RS05150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5F70_RS05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F70_RS05170	COG1276	copper resistance
C5F70_RS05180	COG1309	transcriptional regulator
C5F70_RS05190	COG0493	'glutamate synthase
C5F70_RS05200	COG1953	Uracil, thiamine, allantoin
C5F70_RS05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS05245	COG1477	protein flavinylation
C5F70_RS05285	COG1686	Belongs to the peptidase S11 family
C5F70_RS05295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5F70_RS05320	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5F70_RS05325	COG0740	serine-type endopeptidase activity
C5F70_RS05330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5F70_RS05335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5F70_RS05340	COG0776	regulation of translation
C5F70_RS05345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F70_RS05355	COG0583	DNA-binding transcription factor activity
C5F70_RS05365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5F70_RS05370	COG1846	Transcriptional regulator
C5F70_RS05375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5F70_RS05390	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS05390	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5F70_RS05400	COG3038	cytochrome b561
C5F70_RS05405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5F70_RS05410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5F70_RS05415	COG0583	DNA-binding transcription factor activity
C5F70_RS05420	COG0217	transcriptional regulatory protein
C5F70_RS05430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5F70_RS05470	COG2866	Carboxypeptidase
C5F70_RS05495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5F70_RS05500	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS05505	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS05515	COG0789	Transcriptional regulator
C5F70_RS05525	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS05530	COG2885	chlorophyll binding
C5F70_RS05535	COG0708	Exodeoxyribonuclease III
C5F70_RS05545	COG0729	surface antigen
C5F70_RS05550	COG2911	Protein conserved in bacteria
C5F70_RS05555	COG1846	Transcriptional regulator
C5F70_RS05565	COG1566	PFAM secretion protein HlyD family protein
C5F70_RS05570	COG2814	Major facilitator Superfamily
C5F70_RS05575	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F70_RS05585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5F70_RS05590	COG0215	cysteine-tRNA ligase activity
C5F70_RS05620	COG1320	monovalent cation:proton antiporter activity
C5F70_RS05625	COG2212	antiporter activity
C5F70_RS05630	COG1863	multisubunit Na H antiporter MnhE subunit
C5F70_RS05635	COG0651	ATP synthesis coupled electron transport
C5F70_RS05640	COG1006	Multisubunit Na H antiporter MnhC subunit
C5F70_RS05645	COG2111	Na H antiporter
C5F70_RS05645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5F70_RS05695	COG0577	efflux transmembrane transporter activity
C5F70_RS05695	COG1136	(ABC) transporter
C5F70_RS05700	COG1136	(ABC) transporter
C5F70_RS05700	COG0577	efflux transmembrane transporter activity
C5F70_RS05715	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS05725	COG2814	Major facilitator Superfamily
C5F70_RS05755	COG1007	ATP synthesis coupled electron transport
C5F70_RS05770	COG0713	ATP synthesis coupled electron transport
C5F70_RS05780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F70_RS05785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5F70_RS05790	COG1034	ATP synthesis coupled electron transport
C5F70_RS05805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F70_RS05805	COG0649	NAD binding
C5F70_RS05810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F70_RS05815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5F70_RS05820	COG2224	Isocitrate lyase
C5F70_RS05830	COG2153	protein acetylation
C5F70_RS05835	COG2850	peptidyl-arginine hydroxylation
C5F70_RS05845	COG2915	High frequency lysogenization protein hflD homolog
C5F70_RS05850	COG0482	sulfurtransferase activity
C5F70_RS05870	COG1278	Cold shock
C5F70_RS05875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5F70_RS05880	COG0542	response to heat
C5F70_RS05885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5F70_RS05890	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C5F70_RS05895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C5F70_RS05900	COG1674	ftsk spoiiie
C5F70_RS05905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5F70_RS05910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5F70_RS05915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5F70_RS05920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5F70_RS05925	COG1648	precorrin-2 dehydrogenase activity
C5F70_RS05925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5F70_RS05930	COG0435	Glutathione S-transferase
C5F70_RS05935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5F70_RS05940	COG2920	part of a sulfur-relay system
C5F70_RS05960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F70_RS05965	COG3091	SprT-like family
C5F70_RS05975	COG0037	tRNA processing
C5F70_RS05995	COG1393	Belongs to the ArsC family
C5F70_RS06015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F70_RS06020	COG0784	Response regulator, receiver
C5F70_RS06020	COG2205	protein histidine kinase activity
C5F70_RS06020	COG5002	protein histidine kinase activity
C5F70_RS06040	COG0658	competence protein
C5F70_RS06040	COG2333	competence protein COMEC
C5F70_RS06045	COG0811	peptide transport
C5F70_RS06050	COG0848	biopolymer transport protein
C5F70_RS06055	COG1663	tetraacyldisaccharide 4'-kinase activity
C5F70_RS06060	COG2835	tetraacyldisaccharide 4'-kinase activity
C5F70_RS06065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5F70_RS06070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5F70_RS06075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5F70_RS06245	COG3617	BRO family, N-terminal domain
C5F70_RS06605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5F70_RS06640	COG3284	Transcriptional regulator
C5F70_RS06650	COG3842	ATPase activity
C5F70_RS06660	COG0395	ABC-type sugar transport system, permease component
C5F70_RS06675	COG0531	amino acid
C5F70_RS06700	COG0583	DNA-binding transcription factor activity
C5F70_RS06705	COG0625	glutathione transferase activity
C5F70_RS06710	COG1968	undecaprenyl-diphosphatase activity
C5F70_RS06725	COG1309	transcriptional regulator
C5F70_RS06735	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS06740	COG1063	alcohol dehydrogenase
C5F70_RS06750	COG0583	DNA-binding transcription factor activity
C5F70_RS06875	COG0811	peptide transport
C5F70_RS06905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F70_RS06935	COG0475	glutathione-regulated potassium exporter activity
C5F70_RS06935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5F70_RS06945	COG2207	Transcriptional regulator
C5F70_RS07020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5F70_RS07020	COG1648	precorrin-2 dehydrogenase activity
C5F70_RS07025	COG0535	radical SAM domain protein
C5F70_RS07050	COG3391	amine dehydrogenase activity
C5F70_RS07055	COG2010	Cytochrome c
C5F70_RS07075	COG0714	Associated with various cellular activities
C5F70_RS07110	COG2010	Cytochrome c
C5F70_RS07115	COG3256	nitric oxide reductase
C5F70_RS07130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F70_RS07140	COG3604	Transcriptional regulator
C5F70_RS07145	COG3901	Regulator of nitric oxide reductase transcription
C5F70_RS07145	COG0348	domain, Protein
C5F70_RS07165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C5F70_RS07180	COG2197	response regulator
C5F70_RS07185	COG3850	Histidine kinase
C5F70_RS07195	COG2223	nitrite transmembrane transporter activity
C5F70_RS07200	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C5F70_RS07205	COG1140	nitrate reductase beta subunit
C5F70_RS07210	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C5F70_RS07215	COG2181	nitrate reductase activity
C5F70_RS07230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5F70_RS07230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5F70_RS07275	COG1304	FMN binding
C5F70_RS07285	COG3706	GGDEF domain
C5F70_RS07290	COG0494	nUDIX hydrolase
C5F70_RS07295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5F70_RS07310	COG0587	DNA-directed DNA polymerase activity
C5F70_RS07330	COG5383	Protein conserved in bacteria
C5F70_RS07350	COG0616	signal peptide processing
C5F70_RS07360	COG0583	DNA-binding transcription factor activity
C5F70_RS07370	COG2376	Dihydroxyacetone kinase
C5F70_RS07375	COG1063	alcohol dehydrogenase
C5F70_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS07385	COG1879	ABC-type sugar transport system periplasmic component
C5F70_RS07390	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F70_RS07395	COG1129	ABC transporter
C5F70_RS07400	COG0698	ribose 5-phosphate isomerase
C5F70_RS07425	COG0765	amino acid transport
C5F70_RS07430	COG0765	amino acid transport
C5F70_RS07455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F70_RS07460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F70_RS07470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F70_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS07480	COG2610	gluconate transmembrane transporter activity
C5F70_RS07490	COG4172	Belongs to the ABC transporter superfamily
C5F70_RS07495	COG4239	(ABC) transporter, permease
C5F70_RS07500	COG4174	ABC transporter (Permease)
C5F70_RS07510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F70_RS07530	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5F70_RS07535	COG0303	'Molybdopterin
C5F70_RS07540	COG0826	peptidase U32
C5F70_RS07545	COG0826	peptidase U32
C5F70_RS07550	COG3154	lipid carrier protein
C5F70_RS07555	COG4172	Belongs to the ABC transporter superfamily
C5F70_RS07560	COG4239	(ABC) transporter, permease
C5F70_RS07565	COG4174	ABC transporter (Permease)
C5F70_RS07570	COG4166	transmembrane transport
C5F70_RS07575	COG4166	transmembrane transport
C5F70_RS07580	COG1388	LysM domain
C5F70_RS07580	COG0741	lytic transglycosylase activity
C5F70_RS07585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5F70_RS07595	COG0328	RNA-DNA hybrid ribonuclease activity
C5F70_RS07600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F70_RS07635	COG0431	NADPH-dependent FMN reductase
C5F70_RS07640	COG0028	Belongs to the TPP enzyme family
C5F70_RS07645	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS07650	COG0789	Transcriptional regulator
C5F70_RS07685	COG0316	Belongs to the HesB IscA family
C5F70_RS07685	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5F70_RS07770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5F70_RS07775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5F70_RS07795	COG0308	aminopeptidase N
C5F70_RS07810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5F70_RS07830	COG2194	sulfuric ester hydrolase activity
C5F70_RS07835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5F70_RS07840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5F70_RS07845	COG0561	phosphatase activity
C5F70_RS07930	COG2233	PERMEase
C5F70_RS07950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F70_RS07960	COG1609	Transcriptional regulator
C5F70_RS07985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS07990	COG0745	RESPONSE REGULATOR receiver
C5F70_RS07995	COG2205	protein histidine kinase activity
C5F70_RS08005	COG0730	response to heat
C5F70_RS08015	COG0189	ligase activity
C5F70_RS08020	COG0598	Magnesium transport protein CorA
C5F70_RS08025	COG0024	Methionine aminopeptidase
C5F70_RS08035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5F70_RS08050	COG1070	Carbohydrate kinase
C5F70_RS08070	COG1175	transmembrane transport
C5F70_RS08115	COG1538	Outer membrane efflux protein
C5F70_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS08135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS08140	COG0348	domain, Protein
C5F70_RS08160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5F70_RS08170	COG0784	Response regulator, receiver
C5F70_RS08170	COG4191	Histidine kinase
C5F70_RS08180	COG2814	Major facilitator Superfamily
C5F70_RS08215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5F70_RS08225	COG1024	Enoyl-CoA hydratase
C5F70_RS08230	COG2816	NAD+ diphosphatase activity
C5F70_RS08235	COG0730	response to heat
C5F70_RS08260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5F70_RS08265	COG1595	DNA-templated transcription, initiation
C5F70_RS08285	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5F70_RS08305	COG0840	transmembrane signaling receptor activity
C5F70_RS08310	COG1968	undecaprenyl-diphosphatase activity
C5F70_RS08325	COG0583	DNA-binding transcription factor activity
C5F70_RS08330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F70_RS08345	COG0488	(ABC) transporter
C5F70_RS08355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5F70_RS08390	COG2133	pyrroloquinoline quinone binding
C5F70_RS08405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F70_RS08415	COG2822	iron ion transport
C5F70_RS08425	COG2822	iron ion transport
C5F70_RS08430	COG0672	)-iron permease
C5F70_RS08435	COG2207	Transcriptional regulator
C5F70_RS08490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS08525	COG0640	Transcriptional regulator
C5F70_RS08530	COG0477	Major facilitator Superfamily
C5F70_RS08545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS08575	COG0411	ABC transporter
C5F70_RS08600	COG3384	dioxygenase
C5F70_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS08625	COG2070	2-Nitropropane dioxygenase
C5F70_RS08630	COG3971	2-oxopent-4-enoate hydratase activity
C5F70_RS08635	COG0300	oxidoreductase activity
C5F70_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS08635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5F70_RS08635	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS08635	COG3321	synthase
C5F70_RS08655	COG0840	transmembrane signaling receptor activity
C5F70_RS08695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5F70_RS08710	COG2358	TRAP transporter, solute receptor (TAXI family
C5F70_RS08730	COG1177	transmembrane transport
C5F70_RS08735	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS08740	COG3842	ATPase activity
C5F70_RS08745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5F70_RS08750	COG0174	glutamine synthetase
C5F70_RS08755	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS08760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS08765	COG1917	Cupin 2, conserved barrel domain protein
C5F70_RS08765	COG1396	sequence-specific DNA binding
C5F70_RS08770	COG2204	response regulator
C5F70_RS08775	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C5F70_RS08795	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C5F70_RS08800	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C5F70_RS08805	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C5F70_RS08810	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C5F70_RS08815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5F70_RS08820	COG0298	carbon dioxide binding
C5F70_RS08825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5F70_RS08830	COG1773	rubredoxin
C5F70_RS08835	COG1773	rubredoxin
C5F70_RS08840	COG1773	rubredoxin
C5F70_RS08845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C5F70_RS08850	COG0375	protein maturation
C5F70_RS08855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5F70_RS08860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C5F70_RS08865	COG0298	carbon dioxide binding
C5F70_RS08870	COG0409	Hydrogenase expression formation protein
C5F70_RS08875	COG0309	Hydrogenase expression formation protein (HypE)
C5F70_RS08890	COG1607	acyl-coa hydrolase
C5F70_RS08930	COG0456	acetyltransferase
C5F70_RS08935	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS08945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5F70_RS08960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5F70_RS08965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5F70_RS08970	COG2194	sulfuric ester hydrolase activity
C5F70_RS09020	COG0604	alcohol dehydrogenase
C5F70_RS09020	COG3321	synthase
C5F70_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS09030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS09045	COG0210	DNA helicase
C5F70_RS09065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS09080	COG2197	response regulator
C5F70_RS09085	COG1113	amino acid transport
C5F70_RS09120	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C5F70_RS09135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F70_RS09135	COG1199	ATP-dependent helicase activity
C5F70_RS09145	COG2207	Transcriptional regulator
C5F70_RS09155	COG2308	Evidence 4 Homologs of previously reported genes of
C5F70_RS09170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F70_RS09180	COG1063	alcohol dehydrogenase
C5F70_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS09215	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS09225	COG3038	cytochrome b561
C5F70_RS09235	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F70_RS09240	COG1879	ABC-type sugar transport system periplasmic component
C5F70_RS09250	COG1070	Carbohydrate kinase
C5F70_RS09255	COG1522	sequence-specific DNA binding
C5F70_RS09265	COG0826	peptidase U32
C5F70_RS09280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5F70_RS09290	COG0589	response to stress
C5F70_RS09310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F70_RS09315	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C5F70_RS09325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5F70_RS09340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5F70_RS09355	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS09365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C5F70_RS09370	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C5F70_RS09375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5F70_RS09375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5F70_RS09395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5F70_RS09405	COG0459	protein refolding
C5F70_RS09425	COG0589	response to stress
C5F70_RS09445	COG1796	DNA polymerase
C5F70_RS09445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5F70_RS09455	COG0071	Belongs to the small heat shock protein (HSP20) family
C5F70_RS09465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5F70_RS09470	COG0058	SHG alpha-glucan phosphorylase activity
C5F70_RS09475	COG0297	glycogen (starch) synthase activity
C5F70_RS09480	COG0574	Belongs to the PEP-utilizing enzyme family
C5F70_RS09480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5F70_RS09495	COG2072	flavoprotein involved in K transport
C5F70_RS09500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F70_RS09510	COG2207	Transcriptional regulator
C5F70_RS09510	COG1609	Transcriptional regulator
C5F70_RS09535	COG2207	Transcriptional regulator
C5F70_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS09570	COG1538	Outer membrane efflux protein
C5F70_RS09575	COG2814	Major facilitator Superfamily
C5F70_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS09640	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5F70_RS09650	COG2226	methyltransferase
C5F70_RS09650	COG3433	isochorismatase activity
C5F70_RS09650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5F70_RS09665	COG2375	cellular response to nickel ion
C5F70_RS09665	COG1132	(ABC) transporter
C5F70_RS09670	COG1132	(ABC) transporter
C5F70_RS09790	COG2326	polyphosphate kinase activity
C5F70_RS09865	COG3188	usher protein
C5F70_RS09870	COG3121	Chaperone
C5F70_RS09880	COG0784	Response regulator, receiver
C5F70_RS09880	COG2205	protein histidine kinase activity
C5F70_RS09885	COG2205	protein histidine kinase activity
C5F70_RS09885	COG0784	Response regulator, receiver
C5F70_RS09890	COG2197	response regulator
C5F70_RS09895	COG5001	Diguanylate cyclase
C5F70_RS09900	COG2197	response regulator
C5F70_RS09925	COG2814	Major facilitator Superfamily
C5F70_RS09930	COG4974	Belongs to the 'phage' integrase family
C5F70_RS09940	COG0463	Glycosyl transferase, family 2
C5F70_RS09945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5F70_RS09945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F70_RS09950	COG0726	polysaccharide deacetylase
C5F70_RS09955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5F70_RS09960	COG2076	Multidrug Resistance protein
C5F70_RS09965	COG2076	Multidrug Resistance protein
C5F70_RS09990	COG2124	cytochrome p450
C5F70_RS09995	COG0657	acetylesterase activity
C5F70_RS10000	COG1024	Enoyl-CoA hydratase
C5F70_RS10005	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS10010	COG1024	Enoyl-CoA hydratase
C5F70_RS10015	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS10030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F70_RS10035	COG3781	membrane
C5F70_RS10045	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C5F70_RS10060	COG0745	RESPONSE REGULATOR receiver
C5F70_RS10065	COG0784	Response regulator, receiver
C5F70_RS10065	COG2205	protein histidine kinase activity
C5F70_RS10075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5F70_RS10080	COG2205	protein histidine kinase activity
C5F70_RS10080	COG2198	Histidine kinase
C5F70_RS10080	COG0784	Response regulator, receiver
C5F70_RS10115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5F70_RS10120	COG3278	Belongs to the heme-copper respiratory oxidase family
C5F70_RS10130	COG1794	racemase activity, acting on amino acids and derivatives
C5F70_RS10135	COG1247	-acetyltransferase
C5F70_RS10145	COG1929	Belongs to the glycerate kinase type-1 family
C5F70_RS10150	COG3835	regulator
C5F70_RS10155	COG2271	Major facilitator Superfamily
C5F70_RS10165	COG0583	DNA-binding transcription factor activity
C5F70_RS10170	COG0667	Aldo Keto reductase
C5F70_RS10190	COG0697	spore germination
C5F70_RS10195	COG0583	DNA-binding transcription factor activity
C5F70_RS10200	COG2200	EAL domain
C5F70_RS10225	COG0667	Aldo Keto reductase
C5F70_RS10275	COG3258	Cytochrome c
C5F70_RS10280	COG2863	cytochrome
C5F70_RS10295	COG3145	DNA-N1-methyladenine dioxygenase activity
C5F70_RS10300	COG2169	Transcriptional regulator
C5F70_RS10300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5F70_RS10325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C5F70_RS10350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5F70_RS10360	COG0640	Transcriptional regulator
C5F70_RS10375	COG2207	Transcriptional regulator
C5F70_RS10375	COG1917	Cupin 2, conserved barrel domain protein
C5F70_RS10475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5F70_RS10475	COG2207	Transcriptional regulator
C5F70_RS10480	COG3938	Belongs to the proline racemase family
C5F70_RS10485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F70_RS10490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS10520	COG2271	Major facilitator Superfamily
C5F70_RS10535	COG4770	biotin carboxylase activity
C5F70_RS10540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5F70_RS10545	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5F70_RS10560	COG2186	Transcriptional regulator
C5F70_RS10565	COG4336	lyase activity
C5F70_RS10575	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C5F70_RS10600	COG2366	antibiotic biosynthetic process
C5F70_RS10635	COG2186	Transcriptional regulator
C5F70_RS10640	COG0579	oxidoreductase
C5F70_RS10645	COG0477	Major facilitator Superfamily
C5F70_RS10660	COG1238	metal cluster binding
C5F70_RS10665	COG0596	Alpha beta hydrolase
C5F70_RS10675	COG0297	glycogen (starch) synthase activity
C5F70_RS10680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5F70_RS10685	COG1640	4-alpha-glucanotransferase
C5F70_RS10760	COG0583	DNA-binding transcription factor activity
C5F70_RS10765	COG2814	Major facilitator Superfamily
C5F70_RS10770	COG0251	oxidation-reduction process
C5F70_RS10785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F70_RS10790	COG1802	Transcriptional regulator
C5F70_RS10805	COG0626	cystathionine gamma-synthase activity
C5F70_RS10810	COG1944	ATP diphosphatase activity
C5F70_RS10815	COG0840	transmembrane signaling receptor activity
C5F70_RS10820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5F70_RS10820	COG2146	nitrite reductase [NAD(P)H] activity
C5F70_RS10825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5F70_RS10825	COG2146	nitrite reductase [NAD(P)H] activity
C5F70_RS10830	COG0243	molybdopterin cofactor binding
C5F70_RS10835	COG0583	DNA-binding transcription factor activity
C5F70_RS10850	COG2271	Major facilitator Superfamily
C5F70_RS10900	COG5001	Diguanylate cyclase
C5F70_RS10900	COG3300	MHYT domain
C5F70_RS10905	COG2207	Transcriptional regulator
C5F70_RS10910	COG2223	nitrite transmembrane transporter activity
C5F70_RS10930	COG0154	amidase activity
C5F70_RS10945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS10950	COG0697	spore germination
C5F70_RS11000	COG2079	MmgE PrpD family protein
C5F70_RS11005	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS11010	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C5F70_RS11015	COG0583	DNA-binding transcription factor activity
C5F70_RS11020	COG3791	Glutathione-dependent formaldehyde-activating
C5F70_RS11025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5F70_RS11035	COG2205	protein histidine kinase activity
C5F70_RS11040	COG0745	RESPONSE REGULATOR receiver
C5F70_RS11050	COG0589	response to stress
C5F70_RS11070	COG0814	amino acid
C5F70_RS11080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F70_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS11105	COG2818	Glycosylase
C5F70_RS11140	COG0714	Associated with various cellular activities
C5F70_RS11190	COG2706	6-phosphogluconolactonase activity
C5F70_RS11220	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS11240	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS11260	COG3239	Fatty acid desaturase
C5F70_RS11265	COG2267	carboxylic ester hydrolase activity
C5F70_RS11295	COG0656	L-ascorbic acid biosynthetic process
C5F70_RS11305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5F70_RS11340	COG0625	glutathione transferase activity
C5F70_RS11355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5F70_RS11365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5F70_RS11370	COG3842	ATPase activity
C5F70_RS11380	COG1175	transmembrane transport
C5F70_RS11390	COG1609	Transcriptional regulator
C5F70_RS11400	COG0019	diaminopimelate decarboxylase activity
C5F70_RS11410	COG2066	Belongs to the glutaminase family
C5F70_RS11420	COG2207	Transcriptional regulator
C5F70_RS11430	COG0673	inositol 2-dehydrogenase activity
C5F70_RS11510	COG4211	Belongs to the binding-protein-dependent transport system permease family
C5F70_RS11515	COG1129	ABC transporter
C5F70_RS11530	COG0673	inositol 2-dehydrogenase activity
C5F70_RS11540	COG0673	inositol 2-dehydrogenase activity
C5F70_RS11550	COG3718	enzyme involved in inositol metabolism
C5F70_RS11560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5F70_RS11570	COG0745	RESPONSE REGULATOR receiver
C5F70_RS11590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS11600	COG0174	glutamine synthetase
C5F70_RS11615	COG0022	dehydrogenase e1 component
C5F70_RS11620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5F70_RS11625	COG3284	Transcriptional regulator
C5F70_RS11640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F70_RS11645	COG1522	sequence-specific DNA binding
C5F70_RS11715	COG3675	Pfam Lipase (class 3)
C5F70_RS11810	COG0534	Mate efflux family protein
C5F70_RS11820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F70_RS11845	COG3842	ATPase activity
C5F70_RS11880	COG2202	Pas domain
C5F70_RS11880	COG2205	protein histidine kinase activity
C5F70_RS11895	COG1414	Transcriptional regulator
C5F70_RS11900	COG3842	ATPase activity
C5F70_RS11905	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS11910	COG1177	transmembrane transport
C5F70_RS12010	COG1999	signal sequence binding
C5F70_RS12030	COG2072	flavoprotein involved in K transport
C5F70_RS12055	COG0583	DNA-binding transcription factor activity
C5F70_RS12060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5F70_RS12105	COG2186	Transcriptional regulator
C5F70_RS12125	COG1959	2 iron, 2 sulfur cluster binding
C5F70_RS12145	COG3706	GGDEF domain
C5F70_RS12160	COG2011	ABC-type metal ion transport system permease component
C5F70_RS12195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5F70_RS12200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5F70_RS12215	COG1596	polysaccharide export
C5F70_RS12225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C5F70_RS12225	COG0662	Cupin 2, conserved barrel domain protein
C5F70_RS12230	COG1051	belongs to the nudix hydrolase family
C5F70_RS12235	COG0297	glycogen (starch) synthase activity
C5F70_RS12240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5F70_RS12255	COG0110	maltose O-acetyltransferase activity
C5F70_RS12270	COG0438	transferase activity, transferring glycosyl groups
C5F70_RS12290	COG3206	protein involved in exopolysaccharide biosynthesis
C5F70_RS12290	COG0489	protein tyrosine kinase activity
C5F70_RS12295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5F70_RS12310	COG0583	DNA-binding transcription factor activity
C5F70_RS12320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F70_RS12345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5F70_RS12350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F70_RS12355	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS12385	COG5002	protein histidine kinase activity
C5F70_RS12385	COG5001	Diguanylate cyclase
C5F70_RS12385	COG3447	MASE1 domain protein
C5F70_RS12395	COG0583	DNA-binding transcription factor activity
C5F70_RS12400	COG1335	isochorismatase
C5F70_RS12405	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C5F70_RS12420	COG4977	sequence-specific DNA binding
C5F70_RS12420	COG1917	Cupin 2, conserved barrel domain protein
C5F70_RS12440	COG1741	Belongs to the pirin family
C5F70_RS12460	COG1116	anion transmembrane transporter activity
C5F70_RS12485	COG2814	Major facilitator Superfamily
C5F70_RS12500	COG2207	Transcriptional regulator
C5F70_RS12505	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5F70_RS12510	COG1129	ABC transporter
C5F70_RS12515	COG1879	ABC-type sugar transport system periplasmic component
C5F70_RS12525	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS12550	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS12555	COG0640	Transcriptional regulator
C5F70_RS12570	COG3781	membrane
C5F70_RS12585	COG2267	carboxylic ester hydrolase activity
C5F70_RS12590	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS12600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F70_RS12605	COG2186	Transcriptional regulator
C5F70_RS12625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5F70_RS12630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5F70_RS12635	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS12645	COG3842	ATPase activity
C5F70_RS12660	COG2197	response regulator
C5F70_RS12665	COG3850	Histidine kinase
C5F70_RS12675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F70_RS12685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F70_RS12700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F70_RS12710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5F70_RS12720	COG0004	ammonium transporteR
C5F70_RS12725	COG0069	glutamate synthase activity
C5F70_RS12730	COG2218	PFAM glutamate synthase alpha subunit domain protein
C5F70_RS12735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5F70_RS12755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5F70_RS12770	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5F70_RS12770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F70_RS12830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F70_RS12835	COG1609	Transcriptional regulator
C5F70_RS12835	COG2207	Transcriptional regulator
C5F70_RS12840	COG2115	Belongs to the xylose isomerase family
C5F70_RS12845	COG4213	ABC transporter substrate-binding protein
C5F70_RS12850	COG1129	ABC transporter
C5F70_RS12855	COG4214	carbohydrate transport
C5F70_RS12910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS12920	COG1196	nuclear chromosome segregation
C5F70_RS12920	COG3264	Mechanosensitive ion channel
C5F70_RS12925	COG1414	Transcriptional regulator
C5F70_RS12960	COG2814	Major facilitator Superfamily
C5F70_RS12985	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS12995	COG1022	Amp-dependent synthetase and ligase
C5F70_RS12995	COG3320	Male sterility
C5F70_RS13000	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS13005	COG1024	Enoyl-CoA hydratase
C5F70_RS13020	COG2814	Major facilitator Superfamily
C5F70_RS13045	COG1309	transcriptional regulator
C5F70_RS13065	COG4774	siderophore transport
C5F70_RS13070	COG2814	Major facilitator Superfamily
C5F70_RS13075	COG1595	DNA-templated transcription, initiation
C5F70_RS13080	COG3712	iron ion homeostasis
C5F70_RS13095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5F70_RS13100	COG1120	ATPase activity
C5F70_RS13105	COG2853	Lipoprotein
C5F70_RS13130	COG1064	alcohol dehydrogenase
C5F70_RS13135	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS13160	COG0589	response to stress
C5F70_RS13165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5F70_RS13210	COG0840	transmembrane signaling receptor activity
C5F70_RS13345	COG1335	isochorismatase
C5F70_RS13350	COG0583	DNA-binding transcription factor activity
C5F70_RS13375	COG1566	PFAM secretion protein HlyD family protein
C5F70_RS13385	COG2207	Transcriptional regulator
C5F70_RS13415	COG0322	excinuclease ABC activity
C5F70_RS13420	COG2197	response regulator
C5F70_RS13440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F70_RS13445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5F70_RS13455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS13455	COG2205	protein histidine kinase activity
C5F70_RS13460	COG2197	response regulator
C5F70_RS13470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5F70_RS13490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F70_RS13510	COG2814	Major facilitator Superfamily
C5F70_RS13520	COG0174	glutamine synthetase
C5F70_RS13525	COG4335	DNA alkylation repair
C5F70_RS13580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5F70_RS13585	COG0517	IMP dehydrogenase activity
C5F70_RS13590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5F70_RS13600	COG0583	DNA-binding transcription factor activity
C5F70_RS13605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5F70_RS13630	COG1280	lysine exporter protein (LysE YggA)
C5F70_RS13635	COG0113	porphobilinogen synthase activity
C5F70_RS13640	COG0384	phenazine biosynthesis protein PhzF
C5F70_RS13645	COG0625	glutathione transferase activity
C5F70_RS13655	COG0701	Predicted permease
C5F70_RS13660	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C5F70_RS13665	COG0709	Synthesizes selenophosphate from selenide and ATP
C5F70_RS13670	COG1253	flavin adenine dinucleotide binding
C5F70_RS13680	COG0583	DNA-binding transcription factor activity
C5F70_RS13690	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5F70_RS13715	COG3132	Protein of unknown function, DUF480
C5F70_RS13720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5F70_RS13735	COG0628	permease
C5F70_RS13740	COG0826	peptidase U32
C5F70_RS13750	COG2056	Na+-H+ antiporter family
C5F70_RS13755	COG0840	transmembrane signaling receptor activity
C5F70_RS13785	COG0720	synthase
C5F70_RS13790	COG1051	belongs to the nudix hydrolase family
C5F70_RS13795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5F70_RS13805	COG0402	S-adenosylhomocysteine deaminase activity
C5F70_RS13815	COG2223	nitrite transmembrane transporter activity
C5F70_RS13830	COG2201	protein-glutamate methylesterase activity
C5F70_RS13835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C5F70_RS13845	COG0835	chemotaxis
C5F70_RS13855	COG0840	transmembrane signaling receptor activity
C5F70_RS13860	COG2198	Histidine kinase
C5F70_RS13860	COG0643	Histidine kinase
C5F70_RS13875	COG0840	transmembrane signaling receptor activity
C5F70_RS13895	COG0840	transmembrane signaling receptor activity
C5F70_RS13900	COG0835	chemotaxis
C5F70_RS13915	COG3852	Histidine kinase
C5F70_RS13940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS13960	COG0745	RESPONSE REGULATOR receiver
C5F70_RS13965	COG5002	protein histidine kinase activity
C5F70_RS13990	COG3971	2-oxopent-4-enoate hydratase activity
C5F70_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS14020	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS14025	COG0028	Belongs to the TPP enzyme family
C5F70_RS14040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5F70_RS14055	COG0840	transmembrane signaling receptor activity
C5F70_RS14070	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS14075	COG1024	Enoyl-CoA hydratase
C5F70_RS14090	COG2814	Major facilitator Superfamily
C5F70_RS14115	COG2207	Transcriptional regulator
C5F70_RS14125	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS14135	COG0583	DNA-binding transcription factor activity
C5F70_RS14155	COG3436	PFAM IS66 Orf2 family protein
C5F70_RS14160	COG2433	Pfam Transposase IS66
C5F70_RS14200	COG3210	domain, Protein
C5F70_RS14215	COG2851	Citrate transporter
C5F70_RS14220	COG1301	dicarboxylic acid transport
C5F70_RS14225	COG2828	Protein conserved in bacteria
C5F70_RS14230	COG0583	DNA-binding transcription factor activity
C5F70_RS14235	COG3387	PFAM Glycoside hydrolase 15-related
C5F70_RS14240	COG0596	Alpha beta hydrolase
C5F70_RS14245	COG4977	sequence-specific DNA binding
C5F70_RS14275	COG0417	DNA replication proofreading
C5F70_RS14290	COG0768	penicillin binding
C5F70_RS14330	COG5006	permease, DMT superfamily
C5F70_RS14355	COG0431	NADPH-dependent FMN reductase
C5F70_RS14415	COG1121	(ABC) transporter
C5F70_RS14420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5F70_RS14445	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS14455	COG3842	ATPase activity
C5F70_RS14465	COG3321	synthase
C5F70_RS14465	COG4221	oxidoreductase activity
C5F70_RS14465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5F70_RS14465	COG0604	alcohol dehydrogenase
C5F70_RS14475	COG2200	EAL domain
C5F70_RS14495	COG0545	Peptidyl-prolyl cis-trans isomerase
C5F70_RS14500	COG2010	Cytochrome c
C5F70_RS14520	COG0583	DNA-binding transcription factor activity
C5F70_RS14525	COG0477	Major facilitator Superfamily
C5F70_RS14550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5F70_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS14570	COG4638	Rieske (2fe-2S)
C5F70_RS14585	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS14590	COG0154	amidase activity
C5F70_RS14605	COG0411	ABC transporter
C5F70_RS14615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5F70_RS14645	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS14655	COG1846	Transcriptional regulator
C5F70_RS14660	COG0582	viral genome integration into host DNA
C5F70_RS14675	COG3485	protocatechuate 3,4-dioxygenase
C5F70_RS14680	COG3485	protocatechuate 3,4-dioxygenase
C5F70_RS14685	COG0583	DNA-binding transcription factor activity
C5F70_RS14700	COG2974	May be involved in recombination
C5F70_RS14705	COG0385	Bile acid
C5F70_RS14710	COG2076	Multidrug Resistance protein
C5F70_RS14720	COG0477	Major facilitator Superfamily
C5F70_RS14740	COG0842	Transport permease protein
C5F70_RS14745	COG1131	(ABC) transporter
C5F70_RS14750	COG0625	glutathione transferase activity
C5F70_RS14760	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS14795	COG3540	Alkaline phosphatase
C5F70_RS14800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5F70_RS14820	COG0811	peptide transport
C5F70_RS14835	COG0427	acetyl-CoA hydrolase
C5F70_RS14840	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS14855	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F70_RS14860	COG1309	transcriptional regulator
C5F70_RS14865	COG4566	intracellular signal transduction
C5F70_RS14870	COG4191	Histidine kinase
C5F70_RS14875	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS14890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5F70_RS14960	COG2267	carboxylic ester hydrolase activity
C5F70_RS14965	COG0840	transmembrane signaling receptor activity
C5F70_RS14980	COG2130	NADP-dependent
C5F70_RS14985	COG0284	orotidine-5'-phosphate decarboxylase activity
C5F70_RS15000	COG0628	permease
C5F70_RS15025	COG1022	Amp-dependent synthetase and ligase
C5F70_RS15040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5F70_RS15055	COG2205	protein histidine kinase activity
C5F70_RS15055	COG5002	protein histidine kinase activity
C5F70_RS15055	COG0784	Response regulator, receiver
C5F70_RS15060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5F70_RS15075	COG1741	Belongs to the pirin family
C5F70_RS15085	COG0326	Molecular chaperone. Has ATPase activity
C5F70_RS15120	COG0045	succinate-CoA ligase (ADP-forming) activity
C5F70_RS15125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5F70_RS15140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5F70_RS15145	COG1053	succinate dehydrogenase
C5F70_RS15150	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C5F70_RS15155	COG2009	succinate dehydrogenase
C5F70_RS15175	COG3162	membrane
C5F70_RS15180	COG2113	Glycine betaine
C5F70_RS15200	COG2853	Lipoprotein
C5F70_RS15205	COG1126	abc transporter atp-binding protein
C5F70_RS15220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS15225	COG1309	transcriptional regulator
C5F70_RS15235	COG3960	tartronate-semialdehyde synthase activity
C5F70_RS15240	COG3622	Belongs to the hyi family
C5F70_RS15245	COG2084	Dehydrogenase
C5F70_RS15255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F70_RS15265	COG2814	Major facilitator Superfamily
C5F70_RS15275	COG0583	DNA-binding transcription factor activity
C5F70_RS15280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C5F70_RS15310	COG4235	cytochrome complex assembly
C5F70_RS15315	COG3088	subunit of a heme lyase
C5F70_RS15325	COG1138	Cytochrome C-type biogenesis protein
C5F70_RS15330	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C5F70_RS15350	COG4133	protoheme IX ABC transporter activity
C5F70_RS15360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5F70_RS15365	COG0303	'Molybdopterin
C5F70_RS15370	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5F70_RS15375	COG0746	molybdenum cofactor guanylyltransferase activity
C5F70_RS15405	COG0004	ammonium transporteR
C5F70_RS15440	COG2197	response regulator
C5F70_RS15445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS15445	COG2205	protein histidine kinase activity
C5F70_RS15450	COG1956	GAF domain-containing protein
C5F70_RS15460	COG0784	Response regulator, receiver
C5F70_RS15460	COG5002	protein histidine kinase activity
C5F70_RS15460	COG2205	protein histidine kinase activity
C5F70_RS15465	COG1846	Transcriptional regulator
C5F70_RS15470	COG0386	Belongs to the glutathione peroxidase family
C5F70_RS15475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5F70_RS15480	COG0436	Aminotransferase
C5F70_RS15485	COG0501	Belongs to the peptidase M48B family
C5F70_RS15490	COG0500	methyltransferase
C5F70_RS15495	COG3384	dioxygenase
C5F70_RS15505	COG0513	Belongs to the DEAD box helicase family
C5F70_RS15510	COG1024	Enoyl-CoA hydratase
C5F70_RS15520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C5F70_RS15525	COG3214	Protein conserved in bacteria
C5F70_RS15535	COG0583	DNA-binding transcription factor activity
C5F70_RS15540	COG0730	response to heat
C5F70_RS15545	COG0583	DNA-binding transcription factor activity
C5F70_RS15550	COG1846	Transcriptional regulator
C5F70_RS15555	COG1764	response to oxidative stress
C5F70_RS15560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5F70_RS15575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F70_RS15595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5F70_RS15625	COG1376	ErfK ybiS ycfS ynhG family protein
C5F70_RS15640	COG4181	ATPase activity
C5F70_RS15645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C5F70_RS15650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F70_RS15660	COG1131	(ABC) transporter
C5F70_RS15680	COG2259	Doxx family
C5F70_RS15685	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C5F70_RS15690	COG0084	hydrolase, TatD family'
C5F70_RS15725	COG0745	RESPONSE REGULATOR receiver
C5F70_RS15730	COG2205	protein histidine kinase activity
C5F70_RS15735	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5F70_RS15745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5F70_RS15780	COG1555	photosystem II stabilization
C5F70_RS15790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5F70_RS15795	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5F70_RS15815	COG0367	asparagine synthase
C5F70_RS15835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5F70_RS15845	COG0776	regulation of translation
C5F70_RS15860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5F70_RS15865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5F70_RS15870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F70_RS15880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5F70_RS15890	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5F70_RS15895	COG0402	S-adenosylhomocysteine deaminase activity
C5F70_RS15900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5F70_RS15905	COG0546	phosphoglycolate phosphatase activity
C5F70_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS15915	COG0747	negative chemotaxis
C5F70_RS15925	COG0444	Belongs to the ABC transporter superfamily
C5F70_RS15930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5F70_RS15940	COG0596	Alpha beta hydrolase
C5F70_RS15945	COG2197	response regulator
C5F70_RS15950	COG2267	carboxylic ester hydrolase activity
C5F70_RS15955	COG2233	PERMEase
C5F70_RS15965	COG2814	Major facilitator Superfamily
C5F70_RS15970	COG0583	DNA-binding transcription factor activity
C5F70_RS15975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F70_RS15980	COG0583	DNA-binding transcription factor activity
C5F70_RS15990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5F70_RS16000	COG1611	Belongs to the LOG family
C5F70_RS16020	COG0583	DNA-binding transcription factor activity
C5F70_RS16030	COG0579	oxidoreductase
C5F70_RS16080	COG2046	Belongs to the sulfate adenylyltransferase family
C5F70_RS16080	COG0529	Catalyzes the synthesis of activated sulfate
C5F70_RS16090	COG3436	PFAM IS66 Orf2 family protein
C5F70_RS16390	COG0582	viral genome integration into host DNA
C5F70_RS16395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5F70_RS16400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5F70_RS16410	COG2204	response regulator
C5F70_RS16420	COG2853	Lipoprotein
C5F70_RS16445	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C5F70_RS16445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C5F70_RS16465	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5F70_RS16470	COG1136	(ABC) transporter
C5F70_RS16475	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5F70_RS16485	COG0584	glycerophosphoryl diester phosphodiesterase
C5F70_RS16490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5F70_RS16495	COG1477	protein flavinylation
C5F70_RS16505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5F70_RS16515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5F70_RS16565	COG0183	Belongs to the thiolase family
C5F70_RS16570	COG1024	Enoyl-CoA hydratase
C5F70_RS16570	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F70_RS16580	COG0589	response to stress
C5F70_RS16585	COG0488	(ABC) transporter
C5F70_RS16590	COG0741	lytic transglycosylase activity
C5F70_RS16595	COG1132	(ABC) transporter
C5F70_RS16600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5F70_RS16610	COG0425	Belongs to the sulfur carrier protein TusA family
C5F70_RS16615	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C5F70_RS16630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5F70_RS16635	COG0542	response to heat
C5F70_RS16645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5F70_RS16655	COG0121	glutamine amidotransferase
C5F70_RS16665	COG1770	oligopeptidase
C5F70_RS16700	COG2983	Belongs to the UPF0260 family
C5F70_RS16715	COG3100	YcgL domain-containing protein
C5F70_RS16730	COG0174	glutamine synthetase
C5F70_RS16760	COG0583	DNA-binding transcription factor activity
C5F70_RS16770	COG2910	NAD(P)H-binding
C5F70_RS16775	COG0583	DNA-binding transcription factor activity
C5F70_RS16785	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS16790	COG2807	transmembrane transport
C5F70_RS16830	COG3246	L-lysine catabolic process to acetate
C5F70_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS16840	COG1802	Transcriptional regulator
C5F70_RS16855	COG0583	DNA-binding transcription factor activity
C5F70_RS16885	COG0477	Major facilitator Superfamily
C5F70_RS16890	COG0583	DNA-binding transcription factor activity
C5F70_RS16900	COG2199	diguanylate cyclase activity
C5F70_RS16900	COG2202	Pas domain
C5F70_RS16900	COG2200	EAL domain
C5F70_RS16930	COG3436	PFAM IS66 Orf2 family protein
C5F70_RS16945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5F70_RS16950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5F70_RS16955	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C5F70_RS16960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F70_RS16970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5F70_RS16980	COG0425	Belongs to the sulfur carrier protein TusA family
C5F70_RS16990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5F70_RS17020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C5F70_RS17100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5F70_RS17135	COG3842	ATPase activity
C5F70_RS17150	COG0439	Biotin carboxylase
C5F70_RS17165	COG2267	carboxylic ester hydrolase activity
C5F70_RS17185	COG0640	Transcriptional regulator
C5F70_RS17190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5F70_RS17195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5F70_RS17200	COG0431	NADPH-dependent FMN reductase
C5F70_RS17215	COG0701	Predicted permease
C5F70_RS17240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5F70_RS17275	COG1454	alcohol dehydrogenase
C5F70_RS17285	COG1595	DNA-templated transcription, initiation
C5F70_RS17295	COG1629	transport
C5F70_RS17305	COG0693	protein deglycase activity
C5F70_RS17310	COG0697	spore germination
C5F70_RS17330	COG1704	LemA family
C5F70_RS17340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F70_RS17380	COG2814	Major facilitator Superfamily
C5F70_RS17385	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS17390	COG1309	transcriptional regulator
C5F70_RS17395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS17415	COG0443	Heat shock 70 kDa protein
C5F70_RS17445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F70_RS17450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F70_RS17460	COG0477	Major facilitator Superfamily
C5F70_RS17465	COG3485	protocatechuate 3,4-dioxygenase
C5F70_RS17470	COG3485	protocatechuate 3,4-dioxygenase
C5F70_RS17475	COG0183	Belongs to the thiolase family
C5F70_RS17480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5F70_RS17485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5F70_RS17490	COG2814	Major facilitator Superfamily
C5F70_RS17495	COG1414	Transcriptional regulator
C5F70_RS17505	COG0306	phosphate transporter
C5F70_RS17510	COG0583	DNA-binding transcription factor activity
C5F70_RS17530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5F70_RS17535	COG2271	Major facilitator Superfamily
C5F70_RS17590	COG3220	belongs to the UPF0276 family
C5F70_RS17605	COG0583	DNA-binding transcription factor activity
C5F70_RS17620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C5F70_RS17630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5F70_RS17645	COG0259	pyridoxamine-phosphate oxidase activity
C5F70_RS17665	COG1199	ATP-dependent helicase activity
C5F70_RS17690	COG3012	SEC-C Motif Domain Protein
C5F70_RS17700	COG0653	protein targeting
C5F70_RS17705	COG2366	antibiotic biosynthetic process
C5F70_RS17740	COG0717	Belongs to the dCTP deaminase family
C5F70_RS17745	COG1278	Cold shock
C5F70_RS17760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5F70_RS17765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C5F70_RS17770	COG0585	pseudouridine synthase activity
C5F70_RS17775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5F70_RS17780	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5F70_RS17785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C5F70_RS17795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5F70_RS17805	COG0148	phosphopyruvate hydratase activity
C5F70_RS17810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C5F70_RS17815	COG0504	CTP synthase activity
C5F70_RS17820	COG0037	tRNA processing
C5F70_RS17825	COG0825	malonyl-CoA metabolic process
C5F70_RS17830	COG0587	DNA-directed DNA polymerase activity
C5F70_RS17835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5F70_RS17840	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F70_RS17845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F70_RS17850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5F70_RS17855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5F70_RS17875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5F70_RS17885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5F70_RS17890	COG0233	cytoplasmic translational termination
C5F70_RS17895	COG0528	UMP kinase activity
C5F70_RS17900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5F70_RS17905	COG0052	Belongs to the universal ribosomal protein uS2 family
C5F70_RS17910	COG0024	Methionine aminopeptidase
C5F70_RS17915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C5F70_RS17930	COG0025	NhaP-type Na H and K H
C5F70_RS17935	COG1393	Belongs to the ArsC family
C5F70_RS17940	COG2171	N-acyltransferase activity
C5F70_RS17945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5F70_RS17950	COG2166	iron-sulfur cluster assembly
C5F70_RS17955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5F70_RS17960	COG1215	transferase activity, transferring glycosyl groups
C5F70_RS17965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5F70_RS17970	COG2226	methyltransferase
C5F70_RS17985	COG2937	Belongs to the GPAT DAPAT family
C5F70_RS17990	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C5F70_RS18005	COG1522	sequence-specific DNA binding
C5F70_RS18010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5F70_RS18015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS18025	COG0742	ribosomal rna small subunit methyltransferase
C5F70_RS18040	COG1801	Protein of unknown function DUF72
C5F70_RS18050	COG1214	PFAM Peptidase M22, glycoprotease
C5F70_RS18055	COG0563	adenylate kinase activity
C5F70_RS18060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5F70_RS18075	COG2885	chlorophyll binding
C5F70_RS18090	COG1073	alpha beta
C5F70_RS18110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5F70_RS18120	COG5001	Diguanylate cyclase
C5F70_RS18120	COG3706	GGDEF domain
C5F70_RS18120	COG4251	negative regulation of phosphorylation
C5F70_RS18120	COG2203	Gaf domain
C5F70_RS18125	COG2201	protein-glutamate methylesterase activity
C5F70_RS18140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5F70_RS18140	COG0457	Tetratricopeptide repeat
C5F70_RS18175	COG0583	DNA-binding transcription factor activity
C5F70_RS18185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5F70_RS18190	COG3842	ATPase activity
C5F70_RS18195	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS18200	COG1177	transmembrane transport
C5F70_RS18205	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS18215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C5F70_RS18225	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS18230	COG3158	transport of potassium into the cell
C5F70_RS18235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5F70_RS18250	COG4807	Protein conserved in bacteria
C5F70_RS18265	COG0583	DNA-binding transcription factor activity
C5F70_RS18280	COG3148	PFAM DTW domain containing protein
C5F70_RS18295	COG2137	regulation of response to DNA damage stimulus
C5F70_RS18305	COG1546	Belongs to the CinA family
C5F70_RS18315	COG3179	chitinase
C5F70_RS18405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5F70_RS18415	COG0489	protein tyrosine kinase activity
C5F70_RS18420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5F70_RS18420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5F70_RS18430	COG2878	Part of a membrane complex involved in electron transport
C5F70_RS18435	COG4658	electron transport chain
C5F70_RS18440	COG4659	FMN binding
C5F70_RS18450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5F70_RS18460	COG2197	response regulator
C5F70_RS18465	COG0137	argininosuccinate synthase activity
C5F70_RS18475	COG0418	dihydroorotase activity
C5F70_RS18480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F70_RS18490	COG0450	alkyl hydroperoxide reductase
C5F70_RS18505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C5F70_RS18510	COG0243	molybdopterin cofactor binding
C5F70_RS18515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5F70_RS18520	COG3842	ATPase activity
C5F70_RS18525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5F70_RS18535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5F70_RS18550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS18555	COG0765	amino acid transport
C5F70_RS18560	COG0765	amino acid transport
C5F70_RS18565	COG1126	abc transporter atp-binding protein
C5F70_RS18585	COG2204	response regulator
C5F70_RS18590	COG4191	Histidine kinase
C5F70_RS18605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5F70_RS18620	COG2076	Multidrug Resistance protein
C5F70_RS18640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F70_RS18655	COG0583	DNA-binding transcription factor activity
C5F70_RS18675	COG1858	cytochrome C peroxidase
C5F70_RS18680	COG4191	Histidine kinase
C5F70_RS18695	COG0069	glutamate synthase activity
C5F70_RS18715	COG1113	amino acid transport
C5F70_RS18765	COG1695	Transcriptional regulator
C5F70_RS18770	COG2375	cellular response to nickel ion
C5F70_RS18780	COG4628	conserved protein (DUF2132)
C5F70_RS18785	COG4206	TonB-dependent receptor
C5F70_RS18805	COG0523	cobalamin synthesis protein
C5F70_RS18810	COG0523	cobalamin synthesis protein
C5F70_RS18820	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS18825	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS18850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5F70_RS18865	COG2226	methyltransferase
C5F70_RS18870	COG0500	methyltransferase
C5F70_RS18875	COG0590	tRNA wobble adenosine to inosine editing
C5F70_RS18885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5F70_RS18890	COG1381	Involved in DNA repair and RecF pathway recombination
C5F70_RS18895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5F70_RS18900	COG0571	ribonuclease III activity
C5F70_RS18905	COG0681	Belongs to the peptidase S26 family
C5F70_RS18910	COG0481	GTPase activity
C5F70_RS18915	COG0795	lipopolysaccharide-transporting ATPase activity
C5F70_RS18920	COG0795	lipopolysaccharide-transporting ATPase activity
C5F70_RS18925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5F70_RS18945	COG0525	valine-tRNA ligase activity
C5F70_RS18950	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C5F70_RS18960	COG3081	Nucleoid-associated protein
C5F70_RS18965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5F70_RS19000	COG0583	DNA-binding transcription factor activity
C5F70_RS19005	COG0477	Major facilitator Superfamily
C5F70_RS19035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5F70_RS19050	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5F70_RS19055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C5F70_RS19065	COG2027	D-alanyl-D-alanine carboxypeptidase
C5F70_RS19070	COG4774	siderophore transport
C5F70_RS19080	COG2827	Endonuclease containing a URI domain
C5F70_RS19090	COG3539	Fimbrial protein
C5F70_RS19125	COG3121	Chaperone
C5F70_RS19130	COG3188	usher protein
C5F70_RS19145	COG2807	transmembrane transport
C5F70_RS19150	COG2186	Transcriptional regulator
C5F70_RS19170	COG1126	abc transporter atp-binding protein
C5F70_RS19175	COG0765	amino acid transport
C5F70_RS19180	COG4597	amino acid ABC transporter
C5F70_RS19185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS19190	COG0400	carboxylic ester hydrolase activity
C5F70_RS19195	COG0513	Belongs to the DEAD box helicase family
C5F70_RS19205	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5F70_RS19210	COG0315	cyclic pyranopterin monophosphate synthase activity
C5F70_RS19220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5F70_RS19230	COG3022	response to hydroperoxide
C5F70_RS19240	COG1215	transferase activity, transferring glycosyl groups
C5F70_RS19250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS19255	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C5F70_RS19265	COG3420	alginic acid biosynthetic process
C5F70_RS19280	COG1696	Membrane protein involved in D-alanine export
C5F70_RS19300	COG0662	Cupin 2, conserved barrel domain protein
C5F70_RS19300	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C5F70_RS19310	COG0300	oxidoreductase activity
C5F70_RS19330	COG0577	efflux transmembrane transporter activity
C5F70_RS19330	COG1136	(ABC) transporter
C5F70_RS19340	COG1566	PFAM secretion protein HlyD family protein
C5F70_RS19360	COG0583	DNA-binding transcription factor activity
C5F70_RS19365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F70_RS19370	COG0784	Response regulator, receiver
C5F70_RS19370	COG0835	chemotaxis
C5F70_RS19410	COG5002	protein histidine kinase activity
C5F70_RS19420	COG4251	negative regulation of phosphorylation
C5F70_RS19420	COG3706	GGDEF domain
C5F70_RS19420	COG5001	Diguanylate cyclase
C5F70_RS19420	COG2203	Gaf domain
C5F70_RS19425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C5F70_RS19430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5F70_RS19445	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5F70_RS19450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5F70_RS19455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5F70_RS19460	COG0772	Belongs to the SEDS family
C5F70_RS19465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5F70_RS19470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5F70_RS19475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5F70_RS19480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5F70_RS19495	COG0275	rRNA processing
C5F70_RS19500	COG2001	Belongs to the MraZ family
C5F70_RS19520	COG0792	nuclease activity
C5F70_RS19525	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C5F70_RS19530	COG2823	Periplasmic or secreted lipoprotein
C5F70_RS19535	COG2885	chlorophyll binding
C5F70_RS19540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5F70_RS19725	COG2885	chlorophyll binding
C5F70_RS19765	COG0318	PFAM AMP-dependent synthetase and ligase
C5F70_RS19780	COG1280	lysine exporter protein (LysE YggA)
C5F70_RS19785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5F70_RS19790	COG2813	Specifically methylates the guanine in position
C5F70_RS19795	COG2119	membrane
C5F70_RS19800	COG0501	Belongs to the peptidase M48B family
C5F70_RS19805	COG2135	peptidase activity
C5F70_RS19865	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C5F70_RS19870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5F70_RS19880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F70_RS19885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5F70_RS19890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5F70_RS19895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5F70_RS19915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5F70_RS19920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5F70_RS19925	COG1127	ABC transporter
C5F70_RS19935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C5F70_RS19945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C5F70_RS19950	COG1137	ATPase activity
C5F70_RS19955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5F70_RS19960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5F70_RS19970	COG1660	Displays ATPase and GTPase activities
C5F70_RS20005	COG0312	modulator of DNA gyrase
C5F70_RS20010	COG3028	Belongs to the UPF0307 family
C5F70_RS20015	COG0312	modulator of DNA gyrase
C5F70_RS20020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F70_RS20030	COG1530	ribonuclease E activity
C5F70_RS20035	COG0424	maF-like protein
C5F70_RS20045	COG1792	Involved in formation and maintenance of cell shape
C5F70_RS20050	COG1077	Cell shape determining protein MreB Mrl
C5F70_RS20055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5F70_RS20060	COG0154	amidase activity
C5F70_RS20065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5F70_RS20070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5F70_RS20080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5F70_RS20090	COG2721	sulfolactate sulfo-lyase activity
C5F70_RS20095	COG2271	Major facilitator Superfamily
C5F70_RS20105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5F70_RS20125	COG2186	Transcriptional regulator
C5F70_RS20130	COG2969	positive regulation of protein catabolic process
C5F70_RS20135	COG0625	glutathione transferase activity
C5F70_RS20140	COG2857	Cytochrome c1
C5F70_RS20145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5F70_RS20150	COG0723	plastoquinol--plastocyanin reductase activity
C5F70_RS20155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5F70_RS20160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5F70_RS20165	COG0667	Aldo Keto reductase
C5F70_RS20170	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS20180	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5F70_RS20185	COG0180	Tryptophanyl-tRNA synthetase
C5F70_RS20200	COG4178	(ABC) transporter
C5F70_RS20210	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C5F70_RS20230	COG0747	negative chemotaxis
C5F70_RS20235	COG0747	negative chemotaxis
C5F70_RS20240	COG0747	negative chemotaxis
C5F70_RS20250	COG0747	negative chemotaxis
C5F70_RS20255	COG0601	transmembrane transport
C5F70_RS20260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5F70_RS20265	COG0444	Belongs to the ABC transporter superfamily
C5F70_RS20270	COG4608	Belongs to the ABC transporter superfamily
C5F70_RS20280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5F70_RS20305	COG0019	diaminopimelate decarboxylase activity
C5F70_RS20315	COG3128	pkhd-type hydroxylase
C5F70_RS20320	COG4774	siderophore transport
C5F70_RS20325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5F70_RS20335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C5F70_RS20335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5F70_RS20335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5F70_RS20340	COG1105	Belongs to the carbohydrate kinase PfkB family
C5F70_RS20350	COG1609	Transcriptional regulator
C5F70_RS20355	COG0084	hydrolase, TatD family'
C5F70_RS20375	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5F70_RS20415	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C5F70_RS20420	COG0237	dephospho-CoA kinase activity
C5F70_RS20425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C5F70_RS20455	COG1252	NADH dehydrogenase
C5F70_RS20480	COG0542	response to heat
C5F70_RS20505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS20510	COG2165	general secretion pathway protein
C5F70_RS20535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5F70_RS20540	COG1047	Peptidyl-prolyl cis-trans
C5F70_RS20545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5F70_RS20550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5F70_RS20555	COG0196	riboflavin kinase activity
C5F70_RS20565	COG0268	Binds directly to 16S ribosomal RNA
C5F70_RS20580	COG0280	phosphate acetyltransferase
C5F70_RS20580	COG0857	belongs to the CobB CobQ family
C5F70_RS20585	COG0204	Acyl-transferase
C5F70_RS20595	COG0175	sulfate reduction
C5F70_RS20605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5F70_RS20615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5F70_RS20620	COG1090	epimerase
C5F70_RS20625	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C5F70_RS20640	COG0789	Transcriptional regulator
C5F70_RS20645	COG0415	Belongs to the DNA photolyase family
C5F70_RS20655	COG4221	oxidoreductase activity
C5F70_RS20670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5F70_RS20685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5F70_RS20690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5F70_RS20700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5F70_RS20705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5F70_RS20715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C5F70_RS20720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5F70_RS20730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5F70_RS20735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5F70_RS20740	COG0193	aminoacyl-tRNA hydrolase activity
C5F70_RS20805	COG4792	protein secretion
C5F70_RS20815	COG4794	Type iii secretion
C5F70_RS20840	COG1157	protein secretion by the type III secretion system
C5F70_RS20865	COG2223	nitrite transmembrane transporter activity
C5F70_RS20885	COG2814	Major facilitator Superfamily
C5F70_RS20900	COG0840	transmembrane signaling receptor activity
C5F70_RS20910	COG0583	DNA-binding transcription factor activity
C5F70_RS20925	COG4221	oxidoreductase activity
C5F70_RS20935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5F70_RS20940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS20945	COG4521	taurine ABC transporter
C5F70_RS20950	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5F70_RS20955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F70_RS21060	COG0583	DNA-binding transcription factor activity
C5F70_RS21065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C5F70_RS21075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C5F70_RS21110	COG4974	Belongs to the 'phage' integrase family
C5F70_RS21140	COG0583	DNA-binding transcription factor activity
C5F70_RS21160	COG0840	transmembrane signaling receptor activity
C5F70_RS21175	COG0405	Gamma-glutamyltransferase
C5F70_RS21180	COG1496	oxidoreductase activity
C5F70_RS21210	COG2207	Transcriptional regulator
C5F70_RS21215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5F70_RS21265	COG0477	Major facilitator Superfamily
C5F70_RS21270	COG2031	fatty acid transporter
C5F70_RS21290	COG0288	reversible hydration of carbon dioxide
C5F70_RS21300	COG0456	acetyltransferase
C5F70_RS21325	COG3008	intermembrane lipid transfer
C5F70_RS21330	COG2995	paraquat-inducible protein a
C5F70_RS21335	COG2995	paraquat-inducible protein a
C5F70_RS21385	COG2233	PERMEase
C5F70_RS21390	COG1309	transcriptional regulator
C5F70_RS21410	COG0387	Pfam Sodium calcium exchanger
C5F70_RS21415	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5F70_RS21420	COG0477	Major facilitator Superfamily
C5F70_RS21430	COG0583	DNA-binding transcription factor activity
C5F70_RS21435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5F70_RS21440	COG0604	alcohol dehydrogenase
C5F70_RS21450	COG2814	Major facilitator Superfamily
C5F70_RS21465	COG2217	Heavy metal translocating P-type atpase
C5F70_RS21480	COG0183	Belongs to the thiolase family
C5F70_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS21505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5F70_RS21515	COG4953	penicillin-binding protein 1C
C5F70_RS21525	COG2373	Large extracellular alpha-helical protein
C5F70_RS21530	COG0534	Mate efflux family protein
C5F70_RS21535	COG1166	arginine decarboxylase activity
C5F70_RS21540	COG0023	Translation Initiation Factor
C5F70_RS21565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5F70_RS21580	COG2264	protein methyltransferase activity
C5F70_RS21595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5F70_RS21605	COG0138	bifunctional purine biosynthesis protein purh
C5F70_RS21610	COG0151	Belongs to the GarS family
C5F70_RS21620	COG2095	MarC family integral membrane protein
C5F70_RS21645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5F70_RS21660	COG3657	addiction module killer protein
C5F70_RS21665	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5F70_RS21715	COG0411	ABC transporter
C5F70_RS21725	COG0829	nickel cation binding
C5F70_RS21730	COG0831	urea catabolic process
C5F70_RS21745	COG0832	Belongs to the urease beta subunit family
C5F70_RS21750	COG0804	urea catabolic process
C5F70_RS21755	COG0484	heat shock protein binding
C5F70_RS21760	COG0443	Heat shock 70 kDa protein
C5F70_RS21775	COG0697	spore germination
C5F70_RS21780	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5F70_RS21800	COG2982	Protein involved in outer membrane biogenesis
C5F70_RS21810	COG1309	transcriptional regulator
C5F70_RS21815	COG0791	NLP P60 protein
C5F70_RS21820	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C5F70_RS21825	COG0830	nickel cation binding
C5F70_RS21830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5F70_RS21845	COG4221	oxidoreductase activity
C5F70_RS21880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS21885	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS21890	COG0583	DNA-binding transcription factor activity
C5F70_RS21895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5F70_RS21900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5F70_RS21920	COG2308	Evidence 4 Homologs of previously reported genes of
C5F70_RS21920	COG2307	Protein conserved in bacteria
C5F70_RS21960	COG1032	radical SAM domain protein
C5F70_RS21965	COG0305	Participates in initiation and elongation during chromosome replication
C5F70_RS21970	COG0359	binds to the 23S rRNA
C5F70_RS21980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5F70_RS21985	COG0360	Binds together with S18 to 16S ribosomal RNA
C5F70_RS21990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5F70_RS21995	COG0557	exoribonuclease II activity
C5F70_RS22010	COG1840	ABC-type Fe3 transport system, periplasmic component
C5F70_RS22015	COG1178	ABC-type Fe3 transport system permease component
C5F70_RS22025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5F70_RS22030	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C5F70_RS22035	COG0330	HflC and HflK could
C5F70_RS22040	COG0330	HflC and HflK could
C5F70_RS22045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5F70_RS22050	COG1923	regulation of RNA biosynthetic process
C5F70_RS22055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5F70_RS22060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5F70_RS22065	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5F70_RS22070	COG0802	atpase or kinase
C5F70_RS22075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5F70_RS22075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5F70_RS22085	COG2860	membrane
C5F70_RS22090	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C5F70_RS22095	COG1162	GTPase activity
C5F70_RS22120	COG0688	phosphatidylethanolamine metabolic process
C5F70_RS22125	COG3830	Belongs to the UPF0237 family
C5F70_RS22125	COG0560	Phosphoserine phosphatase
C5F70_RS22155	COG3150	esterase
C5F70_RS22160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5F70_RS22170	COG0494	nUDIX hydrolase
C5F70_RS22185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5F70_RS22190	COG1538	Outer membrane efflux protein
C5F70_RS22195	COG1519	Transferase
C5F70_RS22215	COG0667	Aldo Keto reductase
C5F70_RS22225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5F70_RS22225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5F70_RS22230	COG1132	(ABC) transporter
C5F70_RS22240	COG1215	transferase activity, transferring glycosyl groups
C5F70_RS22245	COG0438	transferase activity, transferring glycosyl groups
C5F70_RS22260	COG2192	nodulation
C5F70_RS22295	COG0438	transferase activity, transferring glycosyl groups
C5F70_RS22300	COG0859	PFAM glycosyl transferase family 9
C5F70_RS22305	COG0859	PFAM glycosyl transferase family 9
C5F70_RS22310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C5F70_RS22330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5F70_RS22335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5F70_RS22340	COG2873	o-acetylhomoserine
C5F70_RS22355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5F70_RS22360	COG0506	proline dehydrogenase activity
C5F70_RS22360	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5F70_RS22360	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5F70_RS22365	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS22385	COG3263	regulation of cellular component size
C5F70_RS22390	COG3264	Mechanosensitive ion channel
C5F70_RS22390	COG1196	nuclear chromosome segregation
C5F70_RS22395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C5F70_RS22400	COG5499	transcription regulator containing HTH domain
C5F70_RS22405	COG4680	protein conserved in bacteria
C5F70_RS22410	COG3118	belongs to the thioredoxin family
C5F70_RS22415	COG1192	Involved in chromosome partitioning
C5F70_RS22430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5F70_RS22435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5F70_RS22445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5F70_RS22460	COG2986	histidine ammonia-lyase
C5F70_RS22485	COG2226	methyltransferase
C5F70_RS22495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F70_RS22505	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS22510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F70_RS22520	COG0583	DNA-binding transcription factor activity
C5F70_RS22525	COG2814	Major facilitator Superfamily
C5F70_RS22535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5F70_RS22540	COG0493	'glutamate synthase
C5F70_RS22545	COG0067	glutamate synthase
C5F70_RS22545	COG0069	glutamate synthase activity
C5F70_RS22545	COG0070	glutamate synthase
C5F70_RS22560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5F70_RS22565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5F70_RS22595	COG0281	malic enzyme
C5F70_RS22605	COG0254	rRNA binding
C5F70_RS22610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5F70_RS22620	COG0018	arginyl-trna synthetase
C5F70_RS22630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5F70_RS22635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5F70_RS22680	COG2226	methyltransferase
C5F70_RS22690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5F70_RS22695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5F70_RS22700	COG0140	phosphoribosyl-ATP diphosphatase activity
C5F70_RS22705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5F70_RS22710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5F70_RS22725	COG0840	transmembrane signaling receptor activity
C5F70_RS22730	COG0840	transmembrane signaling receptor activity
C5F70_RS22735	COG1126	abc transporter atp-binding protein
C5F70_RS22740	COG0765	amino acid transport
C5F70_RS22745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS22755	COG2943	transferase activity, transferring hexosyl groups
C5F70_RS22760	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C5F70_RS22765	COG1490	D-aminoacyl-tRNA deacylase activity
C5F70_RS22785	COG1228	amidohydrolase
C5F70_RS22790	COG2986	histidine ammonia-lyase
C5F70_RS22795	COG2986	histidine ammonia-lyase
C5F70_RS22800	COG4175	Glycine betaine
C5F70_RS22800	COG0517	IMP dehydrogenase activity
C5F70_RS22805	COG4176	ABC-type proline glycine betaine transport system permease component
C5F70_RS22815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5F70_RS22820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5F70_RS22830	COG2188	Transcriptional regulator
C5F70_RS22835	COG0402	S-adenosylhomocysteine deaminase activity
C5F70_RS22850	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C5F70_RS22865	COG0058	SHG alpha-glucan phosphorylase activity
C5F70_RS22875	COG1217	gtp-binding protein TYPA
C5F70_RS22880	COG0301	tRNA thio-modification
C5F70_RS22880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F70_RS22900	COG3852	Histidine kinase
C5F70_RS22925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C5F70_RS22935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F70_RS22940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5F70_RS22945	COG4942	peptidase
C5F70_RS22950	COG0793	Belongs to the peptidase S41A family
C5F70_RS22955	COG2861	carbohydrate metabolic process
C5F70_RS22965	COG0107	imidazoleglycerol-phosphate synthase activity
C5F70_RS22970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5F70_RS22980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5F70_RS22985	COG0131	Imidazoleglycerol-phosphate dehydratase
C5F70_RS22990	COG2223	nitrite transmembrane transporter activity
C5F70_RS23000	COG1194	a g-specific adenine glycosylase
C5F70_RS23005	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C5F70_RS23080	COG3300	MHYT domain
C5F70_RS23080	COG5001	Diguanylate cyclase
C5F70_RS23105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS23115	COG0582	viral genome integration into host DNA
C5F70_RS23145	COG1309	transcriptional regulator
C5F70_RS23150	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS23160	COG2267	carboxylic ester hydrolase activity
C5F70_RS23200	COG2957	Belongs to the agmatine deiminase family
C5F70_RS23205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5F70_RS23230	COG1218	3'(2'),5'-bisphosphate nucleotidase
C5F70_RS23235	COG0494	nUDIX hydrolase
C5F70_RS23240	COG1011	Hydrolase
C5F70_RS23245	COG1652	LysM domain
C5F70_RS23255	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5F70_RS23260	COG0243	molybdopterin cofactor binding
C5F70_RS23270	COG0824	Thioesterase
C5F70_RS23295	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C5F70_RS23300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5F70_RS23310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5F70_RS23315	COG2200	EAL domain
C5F70_RS23320	COG0189	ligase activity
C5F70_RS23320	COG4067	protein conserved in archaea
C5F70_RS23325	COG0189	ligase activity
C5F70_RS23340	COG2183	response to ionizing radiation
C5F70_RS23350	COG2918	glutathione biosynthetic process
C5F70_RS23360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5F70_RS23365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F70_RS23370	COG2175	clavaminate synthase activity
C5F70_RS23375	COG0667	Aldo Keto reductase
C5F70_RS23385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5F70_RS23390	COG1045	serine acetyltransferase
C5F70_RS23395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5F70_RS23400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS23405	COG0765	amino acid transport
C5F70_RS23410	COG1126	abc transporter atp-binding protein
C5F70_RS23440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5F70_RS23445	COG2011	ABC-type metal ion transport system permease component
C5F70_RS23480	COG3829	transcription factor binding
C5F70_RS23495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5F70_RS23505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5F70_RS23510	COG4208	sulfate ABC transporter
C5F70_RS23520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C5F70_RS23545	COG2199	diguanylate cyclase activity
C5F70_RS23555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5F70_RS23560	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS23570	COG0582	viral genome integration into host DNA
C5F70_RS23655	COG1063	alcohol dehydrogenase
C5F70_RS23665	COG1595	DNA-templated transcription, initiation
C5F70_RS23670	COG2304	oxidoreductase activity
C5F70_RS23755	COG1215	transferase activity, transferring glycosyl groups
C5F70_RS23760	COG0726	polysaccharide deacetylase
C5F70_RS23760	COG1649	PFAM Uncharacterised BCR, COG1649
C5F70_RS23765	COG0457	Tetratricopeptide repeat
C5F70_RS23770	COG5339	Protein conserved in bacteria
C5F70_RS23795	COG1289	transmembrane transporter activity
C5F70_RS23880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F70_RS23895	COG2175	clavaminate synthase activity
C5F70_RS23900	COG1802	Transcriptional regulator
C5F70_RS23915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5F70_RS23925	COG0840	transmembrane signaling receptor activity
C5F70_RS23965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5F70_RS23970	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS23975	COG0583	DNA-binding transcription factor activity
C5F70_RS23995	COG0427	acetyl-CoA hydrolase
C5F70_RS24030	COG2851	Citrate transporter
C5F70_RS24035	COG0861	Integral membrane protein TerC family
C5F70_RS24040	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5F70_RS24045	COG0612	Peptidase, M16
C5F70_RS24055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5F70_RS24060	COG1127	ABC transporter
C5F70_RS24075	COG0700	Nucleoside recognition
C5F70_RS24080	COG1301	dicarboxylic acid transport
C5F70_RS24090	COG5487	UPF0391 membrane protein
C5F70_RS24100	COG2204	response regulator
C5F70_RS24105	COG5002	protein histidine kinase activity
C5F70_RS24110	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5F70_RS24125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5F70_RS24135	COG3245	cytochrome
C5F70_RS24140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5F70_RS24160	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C5F70_RS24165	COG0735	belongs to the Fur family
C5F70_RS24170	COG1121	(ABC) transporter
C5F70_RS24175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5F70_RS24190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5F70_RS24195	COG2011	ABC-type metal ion transport system permease component
C5F70_RS24210	COG0109	protoheme IX farnesyltransferase activity
C5F70_RS24240	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C5F70_RS24245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5F70_RS24250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5F70_RS24260	COG0659	secondary active sulfate transmembrane transporter activity
C5F70_RS24300	COG0339	signal peptide processing
C5F70_RS24305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5F70_RS24330	COG1764	response to oxidative stress
C5F70_RS24335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F70_RS24345	COG3360	Dodecin
C5F70_RS24365	COG0159	tryptophan synthase activity
C5F70_RS24380	COG2271	Major facilitator Superfamily
C5F70_RS24385	COG4948	Mandelate Racemase Muconate Lactonizing
C5F70_RS24390	COG0800	Aldolase
C5F70_RS24395	COG3734	2-keto-3-deoxy-galactonokinase
C5F70_RS24405	COG0583	DNA-binding transcription factor activity
C5F70_RS24410	COG3119	arylsulfatase activity
C5F70_RS24425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5F70_RS24430	COG0408	coproporphyrinogen oxidase activity
C5F70_RS24440	COG0009	L-threonylcarbamoyladenylate synthase
C5F70_RS24445	COG0758	DNA mediated transformation
C5F70_RS24455	COG0242	peptide deformylase activity
C5F70_RS24465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5F70_RS24470	COG0569	domain protein
C5F70_RS24485	COG2818	Glycosylase
C5F70_RS24490	COG0752	glycyl-tRNA synthetase alpha subunit
C5F70_RS24495	COG0751	glycine-tRNA ligase activity
C5F70_RS24500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5F70_RS24510	COG5002	protein histidine kinase activity
C5F70_RS24515	COG0745	RESPONSE REGULATOR receiver
C5F70_RS24520	COG0583	DNA-binding transcription factor activity
C5F70_RS24540	COG2124	cytochrome p450
C5F70_RS24545	COG3604	Transcriptional regulator
C5F70_RS24550	COG0426	domain, Protein
C5F70_RS24550	COG1773	rubredoxin
C5F70_RS24560	COG0187	DNA topoisomerase II activity
C5F70_RS24565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5F70_RS24570	COG0592	DNA-directed DNA polymerase activity
C5F70_RS24575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5F70_RS24580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5F70_RS24585	COG0594	ribonuclease P activity
C5F70_RS24590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5F70_RS24595	COG0706	membrane insertase activity
C5F70_RS24600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5F70_RS24610	COG0445	tRNA wobble uridine modification
C5F70_RS24615	COG0357	Ribosomal RNA small subunit methyltransferase G
C5F70_RS24620	COG1192	Involved in chromosome partitioning
C5F70_RS24625	COG1475	DNA binding
C5F70_RS24630	COG3312	ion transport
C5F70_RS24635	COG0356	it plays a direct role in the translocation of protons across the membrane
C5F70_RS24645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5F70_RS24650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5F70_RS24655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5F70_RS24660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5F70_RS24665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5F70_RS24670	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5F70_RS24675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5F70_RS24680	COG1349	DNA-binding transcription factor activity
C5F70_RS24685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5F70_RS24695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS24730	COG4589	Belongs to the CDS family
C5F70_RS24745	COG2453	phosphatase
C5F70_RS24745	COG0671	phosphoesterase, PA-phosphatase related
C5F70_RS24750	COG2267	carboxylic ester hydrolase activity
C5F70_RS24755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5F70_RS24785	COG3220	belongs to the UPF0276 family
C5F70_RS24795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5F70_RS24800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F70_RS24810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5F70_RS24830	COG1121	(ABC) transporter
C5F70_RS24835	COG1469	GTP cyclohydrolase I activity
C5F70_RS24840	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5F70_RS24860	COG0523	cobalamin synthesis protein
C5F70_RS24870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C5F70_RS24875	COG1607	acyl-coa hydrolase
C5F70_RS24880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5F70_RS24880	COG4651	solute:proton antiporter activity
C5F70_RS24895	COG0210	DNA helicase
C5F70_RS24915	COG0583	DNA-binding transcription factor activity
C5F70_RS24920	COG0439	Biotin carboxylase
C5F70_RS24925	COG0511	ligase activity, forming carbon-carbon bonds
C5F70_RS24925	COG5016	pyruvate
C5F70_RS24950	COG0765	amino acid transport
C5F70_RS24955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS25010	COG0252	asparaginase activity
C5F70_RS25015	COG1115	amino acid carrier protein
C5F70_RS25020	COG1027	Aspartate ammonia-lyase
C5F70_RS25025	COG0583	DNA-binding transcription factor activity
C5F70_RS25050	COG0676	glucose-6-phosphate 1-epimerase activity
C5F70_RS25055	COG1607	acyl-coa hydrolase
C5F70_RS25060	COG0477	Major facilitator Superfamily
C5F70_RS25085	COG0573	inorganic phosphate transmembrane transporter activity
C5F70_RS25090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5F70_RS25095	COG0704	Plays a role in the regulation of phosphate uptake
C5F70_RS25105	COG0739	heme binding
C5F70_RS25110	COG1253	flavin adenine dinucleotide binding
C5F70_RS25130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C5F70_RS25135	COG3161	chorismate lyase activity
C5F70_RS25275	COG2815	serine threonine protein kinase
C5F70_RS25275	COG0515	serine threonine protein kinase
C5F70_RS25280	COG1136	(ABC) transporter
C5F70_RS25345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5F70_RS25350	COG0583	DNA-binding transcription factor activity
C5F70_RS25360	COG0848	biopolymer transport protein
C5F70_RS25385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5F70_RS25390	COG1758	RNA polymerase activity
C5F70_RS25395	COG0194	GDP metabolic process
C5F70_RS25400	COG1561	YicC-like family, N-terminal region
C5F70_RS25405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C5F70_RS25415	COG0708	Exodeoxyribonuclease III
C5F70_RS25420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5F70_RS25425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5F70_RS25430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5F70_RS25440	COG0756	dUTP diphosphatase activity
C5F70_RS25445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5F70_RS25450	COG2003	Belongs to the UPF0758 family
C5F70_RS25455	COG0747	negative chemotaxis
C5F70_RS25460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5F70_RS25465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5F70_RS25475	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS25485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5F70_RS25490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS25500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS25515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS25520	COG0251	oxidation-reduction process
C5F70_RS25525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5F70_RS25540	COG0427	acetyl-CoA hydrolase
C5F70_RS25545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5F70_RS25560	COG0534	Mate efflux family protein
C5F70_RS25565	COG0583	DNA-binding transcription factor activity
C5F70_RS25570	COG0840	transmembrane signaling receptor activity
C5F70_RS25580	COG3135	benzoate transporter
C5F70_RS25585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5F70_RS25590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5F70_RS25605	COG3436	PFAM IS66 Orf2 family protein
C5F70_RS25615	COG0606	chelatase, subunit chli
C5F70_RS25625	COG0347	Belongs to the P(II) protein family
C5F70_RS25630	COG0004	ammonium transporteR
C5F70_RS25635	COG0432	Pfam Uncharacterised protein family UPF0047
C5F70_RS25645	COG1011	Hydrolase
C5F70_RS25650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5F70_RS25660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5F70_RS25665	COG0019	diaminopimelate decarboxylase activity
C5F70_RS25675	COG1965	Belongs to the frataxin family
C5F70_RS25685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F70_RS25705	COG0625	glutathione transferase activity
C5F70_RS25710	COG0165	Argininosuccinate lyase
C5F70_RS25720	COG0181	hydroxymethylbilane synthase activity
C5F70_RS25740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C5F70_RS25765	COG0488	(ABC) transporter
C5F70_RS25775	COG1280	lysine exporter protein (LysE YggA)
C5F70_RS25780	COG0672	)-iron permease
C5F70_RS25785	COG1671	Belongs to the UPF0178 family
C5F70_RS25790	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C5F70_RS25800	COG0586	Pfam SNARE associated Golgi protein
C5F70_RS25810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5F70_RS25815	COG0248	Ppx GppA phosphatase
C5F70_RS25825	COG3121	Chaperone
C5F70_RS25830	COG3188	usher protein
C5F70_RS25840	COG1126	abc transporter atp-binding protein
C5F70_RS25845	COG0765	amino acid transport
C5F70_RS25850	COG0765	amino acid transport
C5F70_RS25855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS25865	COG2186	Transcriptional regulator
C5F70_RS25885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5F70_RS25915	COG0842	Transport permease protein
C5F70_RS25920	COG1129	ABC transporter
C5F70_RS25920	COG0842	Transport permease protein
C5F70_RS25925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5F70_RS25935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5F70_RS25955	COG3079	Belongs to the UPF0149 family
C5F70_RS25960	COG0006	proline dipeptidase activity
C5F70_RS25965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F70_RS25970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5F70_RS25980	COG1178	ABC-type Fe3 transport system permease component
C5F70_RS25985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5F70_RS25990	COG0509	glycine decarboxylation via glycine cleavage system
C5F70_RS25995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5F70_RS26015	COG0330	HflC and HflK could
C5F70_RS26020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5F70_RS26030	COG1522	sequence-specific DNA binding
C5F70_RS26045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5F70_RS26045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5F70_RS26055	COG0450	alkyl hydroperoxide reductase
C5F70_RS26060	COG0431	NADPH-dependent FMN reductase
C5F70_RS26065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5F70_RS26070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5F70_RS26075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5F70_RS26080	COG1116	anion transmembrane transporter activity
C5F70_RS26095	COG0174	glutamine synthetase
C5F70_RS26100	COG0174	glutamine synthetase
C5F70_RS26120	COG3842	ATPase activity
C5F70_RS26125	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS26130	COG1177	transmembrane transport
C5F70_RS26200	COG1683	Conserved Protein
C5F70_RS26205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5F70_RS26215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5F70_RS26225	COG0277	FAD linked oxidase domain protein
C5F70_RS26230	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5F70_RS26235	COG3204	pilus organization
C5F70_RS26240	COG3204	pilus organization
C5F70_RS26245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5F70_RS26250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5F70_RS26265	COG0494	nUDIX hydrolase
C5F70_RS26280	COG0730	response to heat
C5F70_RS26285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5F70_RS26290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5F70_RS26295	COG0789	Transcriptional regulator
C5F70_RS26305	COG0583	DNA-binding transcription factor activity
C5F70_RS26315	COG3842	ATPase activity
C5F70_RS26320	COG1178	ABC-type Fe3 transport system permease component
C5F70_RS26325	COG1840	ABC-type Fe3 transport system, periplasmic component
C5F70_RS26345	COG1160	GTP binding
C5F70_RS26360	COG1823	symporter activity
C5F70_RS26370	COG0129	dihydroxy-acid dehydratase activity
C5F70_RS26380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5F70_RS26390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5F70_RS26395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5F70_RS26400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5F70_RS26405	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C5F70_RS26420	COG1309	transcriptional regulator
C5F70_RS26430	COG0429	hydrolase of the alpha beta-hydrolase fold
C5F70_RS26435	COG0742	ribosomal rna small subunit methyltransferase
C5F70_RS26440	COG0612	Peptidase, M16
C5F70_RS26445	COG0612	Peptidase, M16
C5F70_RS26450	COG0552	protein localization to endoplasmic reticulum
C5F70_RS26455	COG2884	Cell division ATP-binding protein ftsE
C5F70_RS26460	COG2177	Part of the ABC transporter FtsEX involved in
C5F70_RS26470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5F70_RS26475	COG2363	Small membrane protein
C5F70_RS26485	COG2022	thiamine diphosphate biosynthetic process
C5F70_RS26490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5F70_RS26500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5F70_RS26505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5F70_RS26515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F70_RS26515	COG2813	Specifically methylates the guanine in position
C5F70_RS26520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5F70_RS26545	COG0791	NLP P60 protein
C5F70_RS26555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5F70_RS26560	COG0540	Belongs to the ATCase OTCase family
C5F70_RS26565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5F70_RS26570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5F70_RS26575	COG1678	Uncharacterized ACR, COG1678
C5F70_RS26585	COG0189	ligase activity
C5F70_RS26610	COG0643	Histidine kinase
C5F70_RS26610	COG0784	Response regulator, receiver
C5F70_RS26610	COG2198	Histidine kinase
C5F70_RS26645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5F70_RS26650	COG3052	prosthetic group binding
C5F70_RS26690	COG1272	protein, Hemolysin III
C5F70_RS26710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5F70_RS26720	COG3038	cytochrome b561
C5F70_RS26725	COG2353	YceI-like domain
C5F70_RS26730	COG0513	Belongs to the DEAD box helicase family
C5F70_RS26745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5F70_RS26750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5F70_RS26765	COG2116	formate transmembrane transporter activity
C5F70_RS26785	COG1422	Protein of unknown function (DUF1090)
C5F70_RS26790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5F70_RS26800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5F70_RS26805	COG0640	Transcriptional regulator
C5F70_RS26810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5F70_RS26815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5F70_RS26820	COG0126	phosphoglycerate kinase activity
C5F70_RS26850	COG1451	nucleotide metabolic process
C5F70_RS26860	COG2153	protein acetylation
C5F70_RS26870	COG1289	transmembrane transporter activity
C5F70_RS26875	COG2081	HI0933 family
C5F70_RS26880	COG0513	Belongs to the DEAD box helicase family
C5F70_RS26885	COG0477	Major facilitator Superfamily
C5F70_RS26905	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C5F70_RS26910	COG1012	belongs to the aldehyde dehydrogenase family
C5F70_RS26915	COG1309	transcriptional regulator
C5F70_RS26920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5F70_RS26925	COG4175	Glycine betaine
C5F70_RS26940	COG1760	l-serine dehydratase
C5F70_RS26960	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5F70_RS26965	COG3246	L-lysine catabolic process to acetate
C5F70_RS26990	COG2304	oxidoreductase activity
C5F70_RS27010	COG1902	pentaerythritol trinitrate reductase activity
C5F70_RS27010	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5F70_RS27015	COG0247	lactate metabolic process
C5F70_RS27015	COG2181	nitrate reductase activity
C5F70_RS27020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5F70_RS27040	COG1017	nitric oxide dioxygenase activity
C5F70_RS27040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F70_RS27055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5F70_RS27085	COG1063	alcohol dehydrogenase
C5F70_RS27125	COG0204	Acyl-transferase
C5F70_RS27130	COG4067	protein conserved in archaea
C5F70_RS27130	COG0189	ligase activity
C5F70_RS27135	COG0745	RESPONSE REGULATOR receiver
C5F70_RS27140	COG2205	protein histidine kinase activity
C5F70_RS27145	COG4452	Inner membrane protein CreD
C5F70_RS27175	COG4774	siderophore transport
C5F70_RS27185	COG1595	DNA-templated transcription, initiation
C5F70_RS27200	COG4566	intracellular signal transduction
C5F70_RS27200	COG0745	RESPONSE REGULATOR receiver
C5F70_RS27205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5F70_RS27220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5F70_RS27230	COG2005	Transcriptional regulator
C5F70_RS27230	COG3585	molybdate ion transport
C5F70_RS27240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5F70_RS27245	COG0156	8-amino-7-oxononanoate synthase activity
C5F70_RS27250	COG1073	alpha beta
C5F70_RS27250	COG2226	methyltransferase
C5F70_RS27270	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS27280	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS27285	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS27290	COG0583	DNA-binding transcription factor activity
C5F70_RS27295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5F70_RS27305	COG0535	radical SAM domain protein
C5F70_RS27315	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C5F70_RS27320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5F70_RS27330	COG1025	Belongs to the peptidase M16 family
C5F70_RS27335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5F70_RS27350	COG0583	DNA-binding transcription factor activity
C5F70_RS27365	COG1192	Involved in chromosome partitioning
C5F70_RS27400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5F70_RS27405	COG0358	DNA primase activity
C5F70_RS27410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5F70_RS27415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5F70_RS27420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C5F70_RS27435	COG0617	tRNA 3'-terminal CCA addition
C5F70_RS27440	COG2719	SpoVR family
C5F70_RS27445	COG2718	Belongs to the UPF0229 family
C5F70_RS27450	COG2766	serine protein kinase
C5F70_RS27455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5F70_RS27460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5F70_RS27465	COG2967	ApaG domain
C5F70_RS27470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5F70_RS27475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5F70_RS27480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5F70_RS27485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C5F70_RS27490	COG3178	'Phosphotransferase
C5F70_RS27495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5F70_RS27500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C5F70_RS27515	COG2197	response regulator
C5F70_RS27520	COG3842	ATPase activity
C5F70_RS27530	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5F70_RS27540	COG1454	alcohol dehydrogenase
C5F70_RS27550	COG0546	phosphoglycolate phosphatase activity
C5F70_RS27560	COG0512	Glutamine amidotransferase of anthranilate synthase
C5F70_RS27565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5F70_RS27570	COG0134	indole-3-glycerol-phosphate synthase activity
C5F70_RS27585	COG1765	OsmC-like protein
C5F70_RS27590	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C5F70_RS27595	COG0537	adenosine 5'-monophosphoramidase activity
C5F70_RS27600	COG4221	oxidoreductase activity
C5F70_RS27615	COG1981	membrane
C5F70_RS27620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5F70_RS27625	COG0316	Belongs to the HesB IscA family
C5F70_RS27630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C5F70_RS27635	COG0739	heme binding
C5F70_RS27640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5F70_RS27680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5F70_RS27720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5F70_RS27725	COG0081	regulation of translation
C5F70_RS27730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5F70_RS27735	COG0222	ribosome binding
C5F70_RS27740	COG0085	RNA polymerase activity
C5F70_RS27745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5F70_RS27750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5F70_RS27755	COG0049	tRNA binding
C5F70_RS27760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5F70_RS27765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5F70_RS27770	COG0051	transcription antitermination factor activity, RNA binding
C5F70_RS27775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5F70_RS27780	COG0088	Forms part of the polypeptide exit tunnel
C5F70_RS27785	COG0089	rRNA binding
C5F70_RS27790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5F70_RS27795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5F70_RS27800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5F70_RS27805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5F70_RS27810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5F70_RS27815	COG0255	Belongs to the universal ribosomal protein uL29 family
C5F70_RS27820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5F70_RS27825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5F70_RS27830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5F70_RS27835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5F70_RS27840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5F70_RS27845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5F70_RS27850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5F70_RS27855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5F70_RS27860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5F70_RS27865	COG1841	ribosomal large subunit assembly
C5F70_RS27870	COG0200	Binds to the 23S rRNA
C5F70_RS27880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5F70_RS27885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5F70_RS27890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5F70_RS27895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5F70_RS27900	COG0202	RNA polymerase activity
C5F70_RS27905	COG0203	ribosomal protein L17
C5F70_RS27915	COG2193	ferroxidase activity
C5F70_RS27920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5F70_RS27925	COG2814	Major facilitator Superfamily
C5F70_RS27930	COG0629	single-stranded DNA binding
C5F70_RS27940	COG4106	trans-aconitate 2-methyltransferase activity
C5F70_RS27945	COG1335	isochorismatase
C5F70_RS27955	COG1201	RNA secondary structure unwinding
C5F70_RS27980	COG4181	ATPase activity
C5F70_RS27995	COG3118	belongs to the thioredoxin family
C5F70_RS28000	COG2264	protein methyltransferase activity
C5F70_RS28015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5F70_RS28015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5F70_RS28030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5F70_RS28035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5F70_RS28040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5F70_RS28045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5F70_RS28055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5F70_RS28060	COG4206	TonB-dependent receptor
C5F70_RS28065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5F70_RS28070	COG0142	geranyltranstransferase activity
C5F70_RS28075	COG1722	exodeoxyribonuclease VII activity
C5F70_RS28095	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5F70_RS28125	COG1335	isochorismatase
C5F70_RS28150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5F70_RS28155	COG3228	Belongs to the MtfA family
C5F70_RS28160	COG0586	Pfam SNARE associated Golgi protein
C5F70_RS28165	COG0456	acetyltransferase
C5F70_RS28170	COG4302	ethanolamine ammonia-lyase activity
C5F70_RS28175	COG4303	Ethanolamine ammonia lyase large subunit
C5F70_RS28180	COG0531	amino acid
C5F70_RS28190	COG3284	Transcriptional regulator
C5F70_RS28200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5F70_RS28215	COG0702	epimerase
C5F70_RS28240	COG1346	cytolysis
C5F70_RS28255	COG0586	Pfam SNARE associated Golgi protein
C5F70_RS28260	COG2094	Belongs to the DNA glycosylase MPG family
C5F70_RS28265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5F70_RS28270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5F70_RS28280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5F70_RS28285	COG0768	penicillin binding
C5F70_RS28290	COG0772	Belongs to the SEDS family
C5F70_RS28295	COG2951	lytic endotransglycosylase activity
C5F70_RS28305	COG1686	Belongs to the peptidase S11 family
C5F70_RS28310	COG2921	Belongs to the UPF0250 family
C5F70_RS28315	COG0321	lipoyl(octanoyl) transferase activity
C5F70_RS28320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5F70_RS28325	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5F70_RS28330	COG2951	lytic endotransglycosylase activity
C5F70_RS28350	COG0495	leucyl-tRNA aminoacylation
C5F70_RS28365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5F70_RS28370	COG4535	Mg2 and Co2 transporter CorC
C5F70_RS28375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5F70_RS28380	COG1702	phosphate starvation-inducible protein PhoH
C5F70_RS28385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5F70_RS28400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5F70_RS28405	COG0352	thiamine-phosphate diphosphorylase activity
C5F70_RS28415	COG2205	protein histidine kinase activity
C5F70_RS28415	COG0784	Response regulator, receiver
C5F70_RS28415	COG2198	Histidine kinase
C5F70_RS28420	COG1960	acyl-CoA dehydrogenase activity
C5F70_RS28425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5F70_RS28440	COG1522	sequence-specific DNA binding
C5F70_RS28450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5F70_RS28460	COG1643	Atp-dependent helicase
C5F70_RS28475	COG3416	Protein conserved in bacteria
C5F70_RS28485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5F70_RS28485	COG1199	ATP-dependent helicase activity
C5F70_RS28505	COG1522	sequence-specific DNA binding
C5F70_RS28510	COG0697	spore germination
C5F70_RS28515	COG0513	Belongs to the DEAD box helicase family
C5F70_RS28520	COG2081	HI0933 family
C5F70_RS28525	COG0123	including yeast histone deacetylase and acetoin utilization protein
C5F70_RS28535	COG1946	Acyl-CoA thioesterase
C5F70_RS28550	COG2321	neutral zinc metallopeptidase
C5F70_RS28565	COG0477	Major facilitator Superfamily
C5F70_RS28570	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C5F70_RS28570	COG1082	Xylose isomerase domain protein TIM barrel
C5F70_RS28575	COG1309	transcriptional regulator
C5F70_RS28580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5F70_RS28585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5F70_RS28600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5F70_RS28605	COG2252	PERMEase
C5F70_RS28620	COG1271	oxidase subunit
C5F70_RS28625	COG1294	oxidase, subunit
C5F70_RS28635	COG2813	Specifically methylates the guanine in position
C5F70_RS28640	COG2197	response regulator
C5F70_RS28650	COG1970	mechanosensitive ion channel activity
C5F70_RS28675	COG1966	Carbon starvation protein
C5F70_RS28680	COG2879	small protein
C5F70_RS28685	COG0523	cobalamin synthesis protein
C5F70_RS28690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5F70_RS28700	COG0488	(ABC) transporter
C5F70_RS28710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F70_RS28735	COG1067	ATP-dependent peptidase activity
C5F70_RS28750	COG2862	Uncharacterized protein family, UPF0114
C5F70_RS28760	COG0840	transmembrane signaling receptor activity
C5F70_RS28770	COG0784	Response regulator, receiver
C5F70_RS28770	COG0835	chemotaxis
C5F70_RS28825	COG0583	DNA-binding transcription factor activity
C5F70_RS28840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5F70_RS28860	COG0129	dihydroxy-acid dehydratase activity
C5F70_RS28865	COG0583	DNA-binding transcription factor activity
C5F70_RS28895	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C5F70_RS28900	COG4647	ligase activity
C5F70_RS28905	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C5F70_RS28925	COG0251	oxidation-reduction process
C5F70_RS28930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5F70_RS28935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5F70_RS28945	COG1126	abc transporter atp-binding protein
C5F70_RS28950	COG0765	amino acid transport
C5F70_RS28955	COG0765	amino acid transport
C5F70_RS28970	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS28975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5F70_RS28980	COG0732	type I restriction modification DNA specificity domain
C5F70_RS28990	COG4804	nuclease activity
C5F70_RS28995	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5F70_RS29015	COG4983	Phage plasmid primase, P4 family domain protein
C5F70_RS29020	COG0582	viral genome integration into host DNA
C5F70_RS29050	COG0247	lactate metabolic process
C5F70_RS29055	COG1620	l-lactate permease
C5F70_RS29060	COG2186	Transcriptional regulator
C5F70_RS29065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5F70_RS29075	COG2914	Belongs to the UPF0125 (RnfH) family
C5F70_RS29080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5F70_RS29090	COG0497	DNA recombination
C5F70_RS29095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5F70_RS29100	COG0443	Heat shock 70 kDa protein
C5F70_RS29105	COG0484	heat shock protein binding
C5F70_RS29110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5F70_RS29115	COG0505	Belongs to the CarA family
C5F70_RS29120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5F70_RS29125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5F70_RS29140	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C5F70_RS29150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5F70_RS29155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5F70_RS29160	COG0149	triose-phosphate isomerase activity
C5F70_RS29165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5F70_RS29180	COG0779	Required for maturation of 30S ribosomal subunits
C5F70_RS29185	COG0195	Participates in both transcription termination and antitermination
C5F70_RS29190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5F70_RS29195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5F70_RS29200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5F70_RS29205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5F70_RS29210	COG1185	polyribonucleotide nucleotidyltransferase activity
C5F70_RS29220	COG2823	Periplasmic or secreted lipoprotein
C5F70_RS29230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5F70_RS29240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5F70_RS29245	COG0166	Belongs to the GPI family
C5F70_RS29250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5F70_RS29255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5F70_RS29275	COG3852	Histidine kinase
C5F70_RS29285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5F70_RS29295	COG0436	Aminotransferase
C5F70_RS29300	COG1489	DNA binding
C5F70_RS29310	COG4558	Periplasmic binding protein
C5F70_RS29315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5F70_RS29320	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5F70_RS29340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5F70_RS29350	COG3098	single-species biofilm formation
C5F70_RS29355	COG0028	Belongs to the TPP enzyme family
C5F70_RS29365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5F70_RS29370	COG1183	phosphatidylcholine synthase activity
C5F70_RS29375	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5F70_RS29380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C5F70_RS29415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5F70_RS29420	COG1074	ATP-dependent DNA helicase activity
C5F70_RS29425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5F70_RS29480	COG3436	PFAM IS66 Orf2 family protein
C5F70_RS29520	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C5F70_RS29525	COG3483	tryptophan 2,3-dioxygenase activity
C5F70_RS29530	COG1113	amino acid transport
C5F70_RS29535	COG0543	2 iron, 2 sulfur cluster binding
C5F70_RS29535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F70_RS29540	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C5F70_RS29545	COG4638	Rieske (2fe-2S)
C5F70_RS29560	COG4948	Mandelate Racemase Muconate Lactonizing
C5F70_RS29565	COG4829	muconolactone delta-isomerase
C5F70_RS29570	COG3485	protocatechuate 3,4-dioxygenase
C5F70_RS29575	COG1522	sequence-specific DNA binding
C5F70_RS29585	COG1113	amino acid transport
C5F70_RS29590	COG0583	DNA-binding transcription factor activity
C5F70_RS29600	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5F70_RS29605	COG0583	DNA-binding transcription factor activity
C5F70_RS29615	COG0659	secondary active sulfate transmembrane transporter activity
C5F70_RS29625	COG2610	gluconate transmembrane transporter activity
C5F70_RS29635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C5F70_RS29645	COG0840	transmembrane signaling receptor activity
C5F70_RS29650	COG0545	Peptidyl-prolyl cis-trans isomerase
C5F70_RS29655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5F70_RS29660	COG2824	Alkylphosphonate utilization operon protein PhnA
C5F70_RS29665	COG0142	geranyltranstransferase activity
C5F70_RS29670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5F70_RS29675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5F70_RS29680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5F70_RS29685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5F70_RS29690	COG3045	CreA protein
C5F70_RS29695	COG0386	Belongs to the glutathione peroxidase family
C5F70_RS29720	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C5F70_RS29725	COG0492	ferredoxin-NADP+ reductase activity
C5F70_RS29740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5F70_RS29745	COG0302	gtp cyclohydrolase
C5F70_RS29760	COG0789	Transcriptional regulator
C5F70_RS29770	COG1366	Belongs to the anti-sigma-factor antagonist family
C5F70_RS29780	COG0583	DNA-binding transcription factor activity
C5F70_RS29785	COG1380	Effector of murein hydrolase LrgA
C5F70_RS29790	COG1346	cytolysis
C5F70_RS29805	COG1028	Short-chain dehydrogenase reductase Sdr
C5F70_RS29820	COG2197	response regulator
C5F70_RS29825	COG2207	Transcriptional regulator
C5F70_RS29825	COG3708	Transcriptional regulator
C5F70_RS29835	COG3604	Transcriptional regulator
C5F70_RS29840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5F70_RS29840	COG1017	nitric oxide dioxygenase activity
C5F70_RS29850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C5F70_RS29860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5F70_RS29865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5F70_RS29870	COG1845	cytochrome c oxidase, subunit III
C5F70_RS29880	COG0109	protoheme IX farnesyltransferase activity
C5F70_RS29885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5F70_RS29960	COG1280	lysine exporter protein (LysE YggA)
C5F70_RS29975	COG0583	DNA-binding transcription factor activity
C5F70_RS29995	COG1279	arginine transmembrane transporter activity
C5F70_RS30010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5F70_RS30035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5F70_RS30065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5F70_RS30070	COG0343	queuine tRNA-ribosyltransferase activity
C5F70_RS30075	COG1862	Preprotein translocase
C5F70_RS30090	COG3134	Outer membrane lipoprotein
C5F70_RS30105	COG1045	serine acetyltransferase
C5F70_RS30115	COG1104	cysteine desulfurase activity
C5F70_RS30125	COG0316	Belongs to the HesB IscA family
C5F70_RS30130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C5F70_RS30135	COG0443	Heat shock 70 kDa protein
C5F70_RS30140	COG0633	Ferredoxin
C5F70_RS30150	COG0105	UTP biosynthetic process
C5F70_RS30155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5F70_RS30165	COG1426	Protein conserved in bacteria
C5F70_RS30165	COG1426	Protein conserved in bacteria
C5F70_RS30170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5F70_RS30175	COG0124	histidyl-tRNA synthetase
C5F70_RS30190	COG1160	GTP binding
C5F70_RS30195	COG0436	Aminotransferase
C5F70_RS30205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5F70_RS30215	COG0739	heme binding
C5F70_RS30220	COG1570	exodeoxyribonuclease VII activity
C5F70_RS30225	COG0583	DNA-binding transcription factor activity
C5F70_RS30250	COG0519	Catalyzes the synthesis of GMP from XMP
C5F70_RS30250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5F70_RS30255	COG2188	Transcriptional regulator
C5F70_RS30260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5F70_RS30260	COG1263	PTS System
C5F70_RS30265	COG0366	Alpha amylase catalytic
C5F70_RS30275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5F70_RS30275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5F70_RS30285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C5F70_RS30290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5F70_RS30290	COG0047	phosphoribosylformylglycinamidine synthase activity
C5F70_RS30300	COG1263	PTS System
C5F70_RS30300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5F70_RS30300	COG2190	(PTS) system
C5F70_RS30305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5F70_RS30305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5F70_RS30310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5F70_RS30315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5F70_RS30320	COG2188	Transcriptional regulator
C5F70_RS30355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C5F70_RS30365	COG4536	flavin adenine dinucleotide binding
C5F70_RS30395	COG0335	large ribosomal subunit rRNA binding