locus-tag	class	description
EAW52_RS00025	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EAW52_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EAW52_RS00045	COG5001	Diguanylate cyclase
EAW52_RS00050	COG4067	protein conserved in archaea
EAW52_RS00050	COG0189	ligase activity
EAW52_RS00055	COG0189	ligase activity
EAW52_RS00070	COG1968	undecaprenyl-diphosphatase activity
EAW52_RS00080	COG2183	response to ionizing radiation
EAW52_RS00110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EAW52_RS00135	COG1178	ABC-type Fe3 transport system permease component
EAW52_RS00145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EAW52_RS00150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EAW52_RS00155	COG0006	proline dipeptidase activity
EAW52_RS00180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EAW52_RS00205	COG2271	Major facilitator Superfamily
EAW52_RS00215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EAW52_RS00250	COG0586	Pfam SNARE associated Golgi protein
EAW52_RS00265	COG0672	)-iron permease
EAW52_RS00280	COG0488	(ABC) transporter
EAW52_RS00295	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS00305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EAW52_RS00310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EAW52_RS00310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EAW52_RS00315	COG0509	glycine decarboxylation via glycine cleavage system
EAW52_RS00320	COG0754	glutathionylspermidine amidase activity
EAW52_RS00330	COG3766	membrane
EAW52_RS00345	COG1846	Transcriptional regulator
EAW52_RS00350	COG1764	response to oxidative stress
EAW52_RS00360	COG2271	Major facilitator Superfamily
EAW52_RS00380	COG0583	DNA-binding transcription factor activity
EAW52_RS00385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EAW52_RS00395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EAW52_RS00425	COG0500	methyltransferase
EAW52_RS00430	COG2207	Transcriptional regulator
EAW52_RS00435	COG1064	alcohol dehydrogenase
EAW52_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS00460	COG5342	invasion associated locus B
EAW52_RS00465	COG2824	Alkylphosphonate utilization operon protein PhnA
EAW52_RS00490	COG1278	Cold shock
EAW52_RS00495	COG0529	Catalyzes the synthesis of activated sulfate
EAW52_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS00595	COG2814	Major facilitator Superfamily
EAW52_RS00615	COG2153	protein acetylation
EAW52_RS00645	COG0840	transmembrane signaling receptor activity
EAW52_RS00695	COG1280	lysine exporter protein (LysE YggA)
EAW52_RS00705	COG1295	ribonuclease BN
EAW52_RS00715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EAW52_RS00730	COG4651	solute:proton antiporter activity
EAW52_RS00730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EAW52_RS00755	COG0659	secondary active sulfate transmembrane transporter activity
EAW52_RS00800	COG2011	ABC-type metal ion transport system permease component
EAW52_RS00810	COG1283	sodium-dependent phosphate transmembrane transporter activity
EAW52_RS00815	COG0676	glucose-6-phosphate 1-epimerase activity
EAW52_RS00845	COG0700	Nucleoside recognition
EAW52_RS00850	COG0655	NAD(P)H dehydrogenase (quinone) activity
EAW52_RS00875	COG5002	protein histidine kinase activity
EAW52_RS00880	COG2814	Major facilitator Superfamily
EAW52_RS00885	COG2375	cellular response to nickel ion
EAW52_RS00890	COG1846	Transcriptional regulator
EAW52_RS00895	COG3023	N-Acetylmuramoyl-L-alanine amidase
EAW52_RS00915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EAW52_RS00935	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EAW52_RS00940	COG0735	belongs to the Fur family
EAW52_RS00945	COG1121	(ABC) transporter
EAW52_RS00950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EAW52_RS00955	COG0473	3-isopropylmalate dehydrogenase activity
EAW52_RS00960	COG0583	DNA-binding transcription factor activity
EAW52_RS00965	COG0656	L-ascorbic acid biosynthetic process
EAW52_RS01005	COG0745	RESPONSE REGULATOR receiver
EAW52_RS01005	COG2972	Histidine kinase
EAW52_RS01015	COG2084	Dehydrogenase
EAW52_RS01020	COG0625	glutathione transferase activity
EAW52_RS01035	COG0598	Magnesium transport protein CorA
EAW52_RS01045	COG3072	Adenylate cyclase
EAW52_RS01050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EAW52_RS01060	COG1965	Belongs to the frataxin family
EAW52_RS01075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EAW52_RS01105	COG0432	Pfam Uncharacterised protein family UPF0047
EAW52_RS01110	COG0004	ammonium transporteR
EAW52_RS01115	COG0347	Belongs to the P(II) protein family
EAW52_RS01125	COG0606	chelatase, subunit chli
EAW52_RS01130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EAW52_RS01140	COG0583	DNA-binding transcription factor activity
EAW52_RS01150	COG1238	metal cluster binding
EAW52_RS01155	COG2132	Multicopper oxidase
EAW52_RS01160	COG3667	copper resistance
EAW52_RS01175	COG3729	General stress protein
EAW52_RS01180	COG3729	General stress protein
EAW52_RS01185	COG3729	General stress protein
EAW52_RS01200	COG2056	Na+-H+ antiporter family
EAW52_RS01205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EAW52_RS01215	COG0596	Alpha beta hydrolase
EAW52_RS01230	COG2828	Protein conserved in bacteria
EAW52_RS01235	COG0210	DNA helicase
EAW52_RS01250	COG1278	Cold shock
EAW52_RS01265	COG0477	Major facilitator Superfamily
EAW52_RS01275	COG0778	Nitroreductase
EAW52_RS01280	COG2814	Major facilitator Superfamily
EAW52_RS01295	COG0028	Belongs to the TPP enzyme family
EAW52_RS01300	COG4221	oxidoreductase activity
EAW52_RS01320	COG0514	ATP-dependent DNA helicase (RecQ)
EAW52_RS01325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EAW52_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS01345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EAW52_RS01350	COG0747	negative chemotaxis
EAW52_RS01355	COG2003	Belongs to the UPF0758 family
EAW52_RS01360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EAW52_RS01365	COG0756	dUTP diphosphatase activity
EAW52_RS01390	COG0708	Exodeoxyribonuclease III
EAW52_RS01405	COG1561	YicC-like family, N-terminal region
EAW52_RS01415	COG1758	RNA polymerase activity
EAW52_RS01420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EAW52_RS01435	COG0583	DNA-binding transcription factor activity
EAW52_RS01440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EAW52_RS01450	COG0673	inositol 2-dehydrogenase activity
EAW52_RS01455	COG1999	signal sequence binding
EAW52_RS01475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EAW52_RS01490	COG0339	signal peptide processing
EAW52_RS01495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EAW52_RS01500	COG0668	transmembrane transport
EAW52_RS01510	COG0243	molybdopterin cofactor binding
EAW52_RS01525	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS01535	COG2205	protein histidine kinase activity
EAW52_RS01540	COG0745	RESPONSE REGULATOR receiver
EAW52_RS01555	COG0577	efflux transmembrane transporter activity
EAW52_RS01555	COG1136	(ABC) transporter
EAW52_RS01600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EAW52_RS01615	COG0625	glutathione transferase activity
EAW52_RS01620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EAW52_RS01625	COG0174	glutamine synthetase
EAW52_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS01650	COG3119	arylsulfatase activity
EAW52_RS01660	COG0583	DNA-binding transcription factor activity
EAW52_RS01670	COG0346	lactoylglutathione lyase activity
EAW52_RS01675	COG2706	6-phosphogluconolactonase activity
EAW52_RS01695	COG1686	Belongs to the peptidase S11 family
EAW52_RS01700	COG0159	tryptophan synthase activity
EAW52_RS01705	COG0133	tryptophan synthase activity
EAW52_RS01720	COG3360	Dodecin
EAW52_RS01725	COG1704	LemA family
EAW52_RS01730	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EAW52_RS01740	COG2814	Major facilitator Superfamily
EAW52_RS01770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EAW52_RS01775	COG1091	dTDP-4-dehydrorhamnose reductase activity
EAW52_RS01780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EAW52_RS01785	COG1733	regulation of RNA biosynthetic process
EAW52_RS01790	COG0667	Aldo Keto reductase
EAW52_RS01795	COG1764	response to oxidative stress
EAW52_RS01800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EAW52_RS01825	COG0758	DNA mediated transformation
EAW52_RS01830	COG1652	LysM domain
EAW52_RS01835	COG0242	peptide deformylase activity
EAW52_RS01840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EAW52_RS01845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EAW52_RS01870	COG2818	Glycosylase
EAW52_RS01910	COG0592	DNA-directed DNA polymerase activity
EAW52_RS01915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EAW52_RS01920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EAW52_RS01930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EAW52_RS01940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EAW52_RS01950	COG0357	Ribosomal RNA small subunit methyltransferase G
EAW52_RS01955	COG1192	Involved in chromosome partitioning
EAW52_RS01960	COG1475	DNA binding
EAW52_RS01970	COG0356	it plays a direct role in the translocation of protons across the membrane
EAW52_RS02005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EAW52_RS02010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EAW52_RS02015	COG1349	DNA-binding transcription factor activity
EAW52_RS02020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EAW52_RS02030	COG0523	cobalamin synthesis protein
EAW52_RS02040	COG1607	acyl-coa hydrolase
EAW52_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS02070	COG0826	peptidase U32
EAW52_RS02095	COG3209	COG3209 Rhs family protein
EAW52_RS02115	COG1737	Transcriptional regulator
EAW52_RS02125	COG0583	DNA-binding transcription factor activity
EAW52_RS02130	COG0439	Biotin carboxylase
EAW52_RS02135	COG5016	pyruvate
EAW52_RS02135	COG0511	ligase activity, forming carbon-carbon bonds
EAW52_RS02140	COG3300	MHYT domain
EAW52_RS02140	COG5001	Diguanylate cyclase
EAW52_RS02145	COG2391	methyltransferase activity
EAW52_RS02150	COG0252	asparaginase activity
EAW52_RS02155	COG1115	amino acid carrier protein
EAW52_RS02170	COG0583	DNA-binding transcription factor activity
EAW52_RS02185	COG2261	transglycosylase associated protein
EAW52_RS02300	COG1607	acyl-coa hydrolase
EAW52_RS02305	COG0477	Major facilitator Superfamily
EAW52_RS02310	COG1473	amidohydrolase
EAW52_RS02325	COG0573	inorganic phosphate transmembrane transporter activity
EAW52_RS02330	COG0573	inorganic phosphate transmembrane transporter activity
EAW52_RS02350	COG0739	heme binding
EAW52_RS02360	COG1253	flavin adenine dinucleotide binding
EAW52_RS02375	COG1414	Transcriptional regulator
EAW52_RS02380	COG3734	2-keto-3-deoxy-galactonokinase
EAW52_RS02385	COG0800	Aldolase
EAW52_RS02390	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS02395	COG2814	Major facilitator Superfamily
EAW52_RS02400	COG2271	Major facilitator Superfamily
EAW52_RS02415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EAW52_RS02445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EAW52_RS02460	COG1011	Hydrolase
EAW52_RS02465	COG0494	nUDIX hydrolase
EAW52_RS02470	COG1218	3'(2'),5'-bisphosphate nucleotidase
EAW52_RS02495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EAW52_RS02510	COG0504	CTP synthase activity
EAW52_RS02625	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EAW52_RS02635	COG0438	transferase activity, transferring glycosyl groups
EAW52_RS02645	COG0529	Catalyzes the synthesis of activated sulfate
EAW52_RS02660	COG2354	Protein conserved in bacteria
EAW52_RS02730	COG0446	pyridine nucleotide-disulphide oxidoreductase
EAW52_RS02730	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS02735	COG2181	nitrate reductase activity
EAW52_RS02735	COG0247	lactate metabolic process
EAW52_RS02755	COG0546	phosphoglycolate phosphatase activity
EAW52_RS02780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EAW52_RS02780	COG1017	nitric oxide dioxygenase activity
EAW52_RS02785	COG0583	DNA-binding transcription factor activity
EAW52_RS02795	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EAW52_RS02820	COG3706	GGDEF domain
EAW52_RS02820	COG5001	Diguanylate cyclase
EAW52_RS02820	COG2203	Gaf domain
EAW52_RS02820	COG4251	negative regulation of phosphorylation
EAW52_RS02825	COG1271	oxidase subunit
EAW52_RS02850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EAW52_RS02865	COG3647	Membrane
EAW52_RS02875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EAW52_RS02920	COG1596	polysaccharide export
EAW52_RS02950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EAW52_RS02955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EAW52_RS02965	COG0864	Transcriptional regulator
EAW52_RS02970	COG0747	negative chemotaxis
EAW52_RS02975	COG0601	transmembrane transport
EAW52_RS02980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAW52_RS02985	COG0444	Belongs to the ABC transporter superfamily
EAW52_RS02990	COG1124	(ABC) transporter
EAW52_RS03010	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EAW52_RS03015	COG1194	a g-specific adenine glycosylase
EAW52_RS03025	COG2223	nitrite transmembrane transporter activity
EAW52_RS03030	COG0131	Imidazoleglycerol-phosphate dehydratase
EAW52_RS03035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EAW52_RS03040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EAW52_RS03060	COG2861	carbohydrate metabolic process
EAW52_RS03065	COG0793	Belongs to the peptidase S41A family
EAW52_RS03070	COG4942	peptidase
EAW52_RS03075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EAW52_RS03080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EAW52_RS03090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EAW52_RS03095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EAW52_RS03110	COG3852	Histidine kinase
EAW52_RS03135	COG1217	gtp-binding protein TYPA
EAW52_RS03140	COG0861	Integral membrane protein TerC family
EAW52_RS03145	COG2851	Citrate transporter
EAW52_RS03180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EAW52_RS03185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS03220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EAW52_RS03225	COG2226	methyltransferase
EAW52_RS03235	COG2814	Major facilitator Superfamily
EAW52_RS03245	COG0583	DNA-binding transcription factor activity
EAW52_RS03250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EAW52_RS03260	COG0126	phosphoglycerate kinase activity
EAW52_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS03305	COG0728	peptidoglycan biosynthetic process
EAW52_RS03320	COG0513	Belongs to the DEAD box helicase family
EAW52_RS03325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EAW52_RS03335	COG5002	protein histidine kinase activity
EAW52_RS03360	COG0477	Major facilitator Superfamily
EAW52_RS03365	COG1450	Type ii and iii secretion system protein
EAW52_RS03390	COG4795	General secretion pathway protein
EAW52_RS03400	COG4970	Tfp pilus assembly protein FimT
EAW52_RS03405	COG2165	general secretion pathway protein
EAW52_RS03410	COG1459	type II secretion system
EAW52_RS03415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EAW52_RS03430	COG0204	Acyl-transferase
EAW52_RS03440	COG4067	protein conserved in archaea
EAW52_RS03440	COG0189	ligase activity
EAW52_RS03450	COG4774	siderophore transport
EAW52_RS03455	COG3712	iron ion homeostasis
EAW52_RS03460	COG1595	DNA-templated transcription, initiation
EAW52_RS03505	COG0697	spore germination
EAW52_RS03515	COG1522	sequence-specific DNA binding
EAW52_RS03525	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS03530	COG4191	Histidine kinase
EAW52_RS03530	COG0784	Response regulator, receiver
EAW52_RS03565	COG0840	transmembrane signaling receptor activity
EAW52_RS03565	COG3290	protein histidine kinase activity
EAW52_RS03570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EAW52_RS03595	COG2005	Transcriptional regulator
EAW52_RS03595	COG3585	molybdate ion transport
EAW52_RS03610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EAW52_RS03620	COG0596	Alpha beta hydrolase
EAW52_RS03620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EAW52_RS03620	COG2226	methyltransferase
EAW52_RS03645	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS03650	COG1566	PFAM secretion protein HlyD family protein
EAW52_RS03670	COG0583	DNA-binding transcription factor activity
EAW52_RS03680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EAW52_RS03690	COG0583	DNA-binding transcription factor activity
EAW52_RS03700	COG2271	Major facilitator Superfamily
EAW52_RS03705	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS03710	COG3254	rhamnose metabolic process
EAW52_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS03725	COG2271	Major facilitator Superfamily
EAW52_RS03735	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS03765	COG2186	Transcriptional regulator
EAW52_RS03770	COG0277	FAD linked oxidase domain protein
EAW52_RS03775	COG0277	FAD linked oxidase domain protein
EAW52_RS03780	COG0247	lactate metabolic process
EAW52_RS03785	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EAW52_RS03790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EAW52_RS03795	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS03805	COG0784	Response regulator, receiver
EAW52_RS03805	COG2198	Histidine kinase
EAW52_RS03805	COG2205	protein histidine kinase activity
EAW52_RS03810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EAW52_RS03820	COG2205	protein histidine kinase activity
EAW52_RS03840	COG0358	DNA primase activity
EAW52_RS03870	COG0617	tRNA 3'-terminal CCA addition
EAW52_RS03875	COG2719	SpoVR family
EAW52_RS03880	COG2718	Belongs to the UPF0229 family
EAW52_RS03885	COG2766	serine protein kinase
EAW52_RS03910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EAW52_RS03935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EAW52_RS03945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EAW52_RS03960	COG0512	Glutamine amidotransferase of anthranilate synthase
EAW52_RS03980	COG1765	OsmC-like protein
EAW52_RS03990	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EAW52_RS03995	COG0537	adenosine 5'-monophosphoramidase activity
EAW52_RS04010	COG1981	membrane
EAW52_RS04025	COG0739	heme binding
EAW52_RS04030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EAW52_RS04060	COG2995	paraquat-inducible protein a
EAW52_RS04065	COG2995	paraquat-inducible protein a
EAW52_RS04070	COG3008	intermembrane lipid transfer
EAW52_RS04095	COG0456	acetyltransferase
EAW52_RS04160	COG0535	radical SAM domain protein
EAW52_RS04170	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EAW52_RS04175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EAW52_RS04185	COG1025	Belongs to the peptidase M16 family
EAW52_RS04200	COG2195	Cleaves the N-terminal amino acid of tripeptides
EAW52_RS04220	COG4650	regulator
EAW52_RS04245	COG3546	catalase activity
EAW52_RS04255	COG0430	RNA-3'-phosphate cyclase activity
EAW52_RS04260	COG1690	Belongs to the RtcB family
EAW52_RS04285	COG2814	Major facilitator Superfamily
EAW52_RS04295	COG1024	Enoyl-CoA hydratase
EAW52_RS04300	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS04305	COG1021	2,3-dihydroxybenzoate-AMP ligase
EAW52_RS04315	COG0183	Belongs to the thiolase family
EAW52_RS04320	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS04325	COG2814	Major facilitator Superfamily
EAW52_RS04335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EAW52_RS04335	COG0506	proline dehydrogenase activity
EAW52_RS04335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EAW52_RS04345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EAW52_RS04365	COG0583	DNA-binding transcription factor activity
EAW52_RS04370	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS04375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS04405	COG2423	ornithine cyclodeaminase activity
EAW52_RS04410	COG4221	oxidoreductase activity
EAW52_RS04415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EAW52_RS04420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EAW52_RS04440	COG1115	amino acid carrier protein
EAW52_RS04445	COG1230	cation diffusion facilitator family transporter
EAW52_RS04455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EAW52_RS04465	COG0450	alkyl hydroperoxide reductase
EAW52_RS04505	COG1794	racemase activity, acting on amino acids and derivatives
EAW52_RS04525	COG0811	peptide transport
EAW52_RS04545	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EAW52_RS04550	COG0830	nickel cation binding
EAW52_RS04555	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EAW52_RS04595	COG0346	lactoylglutathione lyase activity
EAW52_RS04600	COG3265	gluconokinase activity
EAW52_RS04605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EAW52_RS04610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EAW52_RS04615	COG0431	NADPH-dependent FMN reductase
EAW52_RS04620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EAW52_RS04625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EAW52_RS04635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EAW52_RS04645	COG3585	molybdate ion transport
EAW52_RS04650	COG1272	protein, Hemolysin III
EAW52_RS04655	COG1278	Cold shock
EAW52_RS04670	COG1278	Cold shock
EAW52_RS04680	COG3729	General stress protein
EAW52_RS04690	COG0450	alkyl hydroperoxide reductase
EAW52_RS04695	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EAW52_RS04700	COG0745	RESPONSE REGULATOR receiver
EAW52_RS04710	COG5001	Diguanylate cyclase
EAW52_RS04710	COG3300	MHYT domain
EAW52_RS04720	COG0038	chloride channel
EAW52_RS04725	COG0477	Major facilitator Superfamily
EAW52_RS04730	COG2204	response regulator
EAW52_RS04735	COG4191	Histidine kinase
EAW52_RS04750	COG3530	Putative quorum-sensing-regulated virulence factor
EAW52_RS04755	COG0784	Response regulator, receiver
EAW52_RS04755	COG0835	chemotaxis
EAW52_RS04760	COG0840	transmembrane signaling receptor activity
EAW52_RS04770	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EAW52_RS04785	COG2205	protein histidine kinase activity
EAW52_RS04825	COG0753	catalase activity
EAW52_RS04835	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EAW52_RS04840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS04845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS04850	COG1120	ATPase activity
EAW52_RS04870	COG0739	heme binding
EAW52_RS04875	COG1280	lysine exporter protein (LysE YggA)
EAW52_RS04880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EAW52_RS04885	COG0581	inorganic phosphate transmembrane transporter activity
EAW52_RS04890	COG0573	inorganic phosphate transmembrane transporter activity
EAW52_RS04895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EAW52_RS04910	COG1064	alcohol dehydrogenase
EAW52_RS04915	COG0563	adenylate kinase activity
EAW52_RS04935	COG5001	Diguanylate cyclase
EAW52_RS04940	COG1280	lysine exporter protein (LysE YggA)
EAW52_RS04950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EAW52_RS04955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EAW52_RS04965	COG4172	Belongs to the ABC transporter superfamily
EAW52_RS04970	COG4239	(ABC) transporter, permease
EAW52_RS04975	COG4174	ABC transporter (Permease)
EAW52_RS04980	COG4166	transmembrane transport
EAW52_RS05020	COG0604	alcohol dehydrogenase
EAW52_RS05020	COG3321	synthase
EAW52_RS05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EAW52_RS05040	COG3386	PFAM SMP-30 Gluconolaconase
EAW52_RS05075	COG1301	dicarboxylic acid transport
EAW52_RS05085	COG4191	Histidine kinase
EAW52_RS05085	COG0784	Response regulator, receiver
EAW52_RS05095	COG2249	NAD(P)H dehydrogenase (quinone) activity
EAW52_RS05100	COG0583	DNA-binding transcription factor activity
EAW52_RS05135	COG3590	peptidase
EAW52_RS05140	COG0469	pyruvate kinase activity
EAW52_RS05150	COG3284	Transcriptional regulator
EAW52_RS05165	COG0596	Alpha beta hydrolase
EAW52_RS05170	COG2205	protein histidine kinase activity
EAW52_RS05175	COG1280	lysine exporter protein (LysE YggA)
EAW52_RS05180	COG0277	FAD linked oxidase domain protein
EAW52_RS05185	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS05200	COG4251	negative regulation of phosphorylation
EAW52_RS05200	COG3706	GGDEF domain
EAW52_RS05200	COG5001	Diguanylate cyclase
EAW52_RS05200	COG2203	Gaf domain
EAW52_RS05205	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EAW52_RS05210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EAW52_RS05220	COG5383	Protein conserved in bacteria
EAW52_RS05225	COG0667	Aldo Keto reductase
EAW52_RS05245	COG1129	ABC transporter
EAW52_RS05250	COG1172	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS05255	COG1609	Transcriptional regulator
EAW52_RS05260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAW52_RS05265	COG1869	D-ribose catabolic process
EAW52_RS05275	COG2267	carboxylic ester hydrolase activity
EAW52_RS05295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EAW52_RS05305	COG0531	amino acid
EAW52_RS05310	COG1940	carbohydrate kinase activity
EAW52_RS05320	COG0210	DNA helicase
EAW52_RS05325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EAW52_RS05390	COG0582	viral genome integration into host DNA
EAW52_RS05405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EAW52_RS05420	COG4208	sulfate ABC transporter
EAW52_RS05430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EAW52_RS05435	COG5583	Uncharacterized small protein (DUF2292)
EAW52_RS05445	COG2199	diguanylate cyclase activity
EAW52_RS05485	COG0174	glutamine synthetase
EAW52_RS05490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EAW52_RS05495	COG0174	glutamine synthetase
EAW52_RS05515	COG3842	ATPase activity
EAW52_RS05520	COG1176	ABC-type spermidine putrescine transport system, permease component I
EAW52_RS05525	COG1177	transmembrane transport
EAW52_RS05530	COG0561	phosphatase activity
EAW52_RS05535	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EAW52_RS05540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EAW52_RS05560	COG0583	DNA-binding transcription factor activity
EAW52_RS05565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EAW52_RS05585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAW52_RS05595	COG3718	enzyme involved in inositol metabolism
EAW52_RS05600	COG0477	Major facilitator Superfamily
EAW52_RS05600	COG2814	Major facilitator Superfamily
EAW52_RS05615	COG3962	Belongs to the TPP enzyme family
EAW52_RS05620	COG0673	inositol 2-dehydrogenase activity
EAW52_RS05625	COG1082	Xylose isomerase domain protein TIM barrel
EAW52_RS05630	COG0673	inositol 2-dehydrogenase activity
EAW52_RS05650	COG1879	ABC-type sugar transport system periplasmic component
EAW52_RS05655	COG1129	ABC transporter
EAW52_RS05660	COG4211	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS05700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EAW52_RS05735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EAW52_RS05745	COG0415	Belongs to the DNA photolyase family
EAW52_RS05750	COG0789	Transcriptional regulator
EAW52_RS05755	COG3272	Protein of unknown function (DUF1722)
EAW52_RS05760	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EAW52_RS05765	COG1090	epimerase
EAW52_RS05770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EAW52_RS05780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EAW52_RS05785	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EAW52_RS05830	COG0501	Belongs to the peptidase M48B family
EAW52_RS05835	COG2119	membrane
EAW52_RS05840	COG2813	Specifically methylates the guanine in position
EAW52_RS05845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EAW52_RS05850	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EAW52_RS05860	COG0204	Acyl-transferase
EAW52_RS05875	COG0386	Belongs to the glutathione peroxidase family
EAW52_RS05885	COG0450	alkyl hydroperoxide reductase
EAW52_RS05890	COG0492	ferredoxin-NADP+ reductase activity
EAW52_RS05905	COG3038	cytochrome b561
EAW52_RS05930	COG0513	Belongs to the DEAD box helicase family
EAW52_RS05935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EAW52_RS05940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EAW52_RS05945	COG1607	acyl-coa hydrolase
EAW52_RS05950	COG1309	transcriptional regulator
EAW52_RS05955	COG1953	Uracil, thiamine, allantoin
EAW52_RS05965	COG2233	PERMEase
EAW52_RS05970	COG0586	Pfam SNARE associated Golgi protein
EAW52_RS05980	COG5001	Diguanylate cyclase
EAW52_RS06030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EAW52_RS06035	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EAW52_RS06055	COG0443	Heat shock 70 kDa protein
EAW52_RS06070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EAW52_RS06075	COG0693	protein deglycase activity
EAW52_RS06085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EAW52_RS06095	COG0058	SHG alpha-glucan phosphorylase activity
EAW52_RS06100	COG1523	belongs to the glycosyl hydrolase 13 family
EAW52_RS06140	COG0534	Mate efflux family protein
EAW52_RS06150	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EAW52_RS06180	COG1984	allophanate hydrolase subunit 2
EAW52_RS06210	COG4251	negative regulation of phosphorylation
EAW52_RS06210	COG2203	Gaf domain
EAW52_RS06210	COG5001	Diguanylate cyclase
EAW52_RS06210	COG3706	GGDEF domain
EAW52_RS06225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EAW52_RS06230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EAW52_RS06240	COG2217	Heavy metal translocating P-type atpase
EAW52_RS06255	COG1309	transcriptional regulator
EAW52_RS06260	COG2814	Major facilitator Superfamily
EAW52_RS06280	COG0583	DNA-binding transcription factor activity
EAW52_RS06290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EAW52_RS06295	COG0387	Pfam Sodium calcium exchanger
EAW52_RS06300	COG0004	ammonium transporteR
EAW52_RS06355	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EAW52_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS06430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EAW52_RS06435	COG0583	DNA-binding transcription factor activity
EAW52_RS06440	COG3485	protocatechuate 3,4-dioxygenase
EAW52_RS06445	COG3485	protocatechuate 3,4-dioxygenase
EAW52_RS06450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EAW52_RS06460	COG3938	Belongs to the proline racemase family
EAW52_RS06485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EAW52_RS06490	COG1414	Transcriptional regulator
EAW52_RS06500	COG0183	Belongs to the thiolase family
EAW52_RS06505	COG0477	Major facilitator Superfamily
EAW52_RS06515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EAW52_RS06520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EAW52_RS06530	COG2897	thiosulfate sulfurtransferase activity
EAW52_RS06535	COG1045	serine acetyltransferase
EAW52_RS06545	COG0484	heat shock protein binding
EAW52_RS06550	COG0789	Transcriptional regulator
EAW52_RS06555	COG4991	sh3 domain protein
EAW52_RS06560	COG0494	nUDIX hydrolase
EAW52_RS06580	COG0425	Belongs to the sulfur carrier protein TusA family
EAW52_RS06595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EAW52_RS06600	COG0840	transmembrane signaling receptor activity
EAW52_RS06605	COG0494	nUDIX hydrolase
EAW52_RS06615	COG0804	urea catabolic process
EAW52_RS06620	COG0832	Belongs to the urease beta subunit family
EAW52_RS06635	COG0831	urea catabolic process
EAW52_RS06640	COG0829	nickel cation binding
EAW52_RS06665	COG0683	leucine binding
EAW52_RS06675	COG0151	Belongs to the GarS family
EAW52_RS06680	COG0138	bifunctional purine biosynthesis protein purh
EAW52_RS06700	COG2264	protein methyltransferase activity
EAW52_RS06715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EAW52_RS06735	COG0667	Aldo Keto reductase
EAW52_RS06740	COG0023	Translation Initiation Factor
EAW52_RS06745	COG1166	arginine decarboxylase activity
EAW52_RS06750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EAW52_RS06755	COG2363	Small membrane protein
EAW52_RS06780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EAW52_RS06790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EAW52_RS06790	COG2813	Specifically methylates the guanine in position
EAW52_RS06795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EAW52_RS06830	COG1573	uracil-dna glycosylase
EAW52_RS06840	COG0791	NLP P60 protein
EAW52_RS06855	COG0540	Belongs to the ATCase OTCase family
EAW52_RS06910	COG2198	Histidine kinase
EAW52_RS06910	COG0784	Response regulator, receiver
EAW52_RS06910	COG0643	Histidine kinase
EAW52_RS06925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EAW52_RS06965	COG1346	cytolysis
EAW52_RS06980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EAW52_RS07010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EAW52_RS07015	COG0315	cyclic pyranopterin monophosphate synthase activity
EAW52_RS07020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EAW52_RS07045	COG0400	carboxylic ester hydrolase activity
EAW52_RS07050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EAW52_RS07055	COG4597	amino acid ABC transporter
EAW52_RS07060	COG0765	amino acid transport
EAW52_RS07065	COG1126	abc transporter atp-binding protein
EAW52_RS07070	COG2827	Endonuclease containing a URI domain
EAW52_RS07085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EAW52_RS07115	COG0795	lipopolysaccharide-transporting ATPase activity
EAW52_RS07120	COG0795	lipopolysaccharide-transporting ATPase activity
EAW52_RS07130	COG3781	membrane
EAW52_RS07155	COG1862	Preprotein translocase
EAW52_RS07170	COG3134	Outer membrane lipoprotein
EAW52_RS07175	COG2823	Periplasmic or secreted lipoprotein
EAW52_RS07180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EAW52_RS07230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EAW52_RS07235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EAW52_RS07240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EAW52_RS07245	COG0772	Belongs to the SEDS family
EAW52_RS07250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EAW52_RS07255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EAW52_RS07280	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EAW52_RS07305	COG0352	thiamine-phosphate diphosphorylase activity
EAW52_RS07315	COG2096	Adenosyltransferase
EAW52_RS07330	COG1666	GTP binding
EAW52_RS07335	COG0668	transmembrane transport
EAW52_RS07345	COG3695	enzyme binding
EAW52_RS07360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EAW52_RS07390	COG3642	lipopolysaccharide core region biosynthetic process
EAW52_RS07400	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EAW52_RS07450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EAW52_RS07460	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS07465	COG2814	Major facilitator Superfamily
EAW52_RS07475	COG2885	chlorophyll binding
EAW52_RS07490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EAW52_RS07495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EAW52_RS07495	COG2755	lipolytic protein G-D-S-L family
EAW52_RS07500	COG0693	protein deglycase activity
EAW52_RS07520	COG0469	pyruvate kinase activity
EAW52_RS07545	COG0714	Associated with various cellular activities
EAW52_RS07570	COG2925	Exonuclease
EAW52_RS07580	COG0788	formyltetrahydrofolate deformylase activity
EAW52_RS07600	COG0438	transferase activity, transferring glycosyl groups
EAW52_RS07605	COG0667	Aldo Keto reductase
EAW52_RS07610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EAW52_RS07620	COG2847	Copper chaperone PCu(A)C
EAW52_RS07640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAW52_RS07645	COG0601	transmembrane transport
EAW52_RS07650	COG0747	negative chemotaxis
EAW52_RS07665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EAW52_RS07680	COG0546	phosphoglycolate phosphatase activity
EAW52_RS07685	COG2321	neutral zinc metallopeptidase
EAW52_RS07705	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EAW52_RS07725	COG0583	DNA-binding transcription factor activity
EAW52_RS07735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EAW52_RS07740	COG2252	PERMEase
EAW52_RS07745	COG0477	Major facilitator Superfamily
EAW52_RS07755	COG0693	protein deglycase activity
EAW52_RS07765	COG2080	2 iron, 2 sulfur cluster binding
EAW52_RS07770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EAW52_RS07775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EAW52_RS07785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EAW52_RS07790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EAW52_RS07800	COG0628	permease
EAW52_RS07815	COG1393	Belongs to the ArsC family
EAW52_RS07820	COG1295	ribonuclease BN
EAW52_RS07825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EAW52_RS07855	COG2900	Belongs to the SlyX family
EAW52_RS07860	COG1278	Cold shock
EAW52_RS07865	COG0783	Belongs to the Dps family
EAW52_RS07870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EAW52_RS07880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EAW52_RS07895	COG0824	Thioesterase
EAW52_RS07925	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EAW52_RS07930	COG0602	queuosine metabolic process
EAW52_RS07935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EAW52_RS07955	COG0425	Belongs to the sulfur carrier protein TusA family
EAW52_RS07960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EAW52_RS07965	COG2716	regulation of RNA biosynthetic process
EAW52_RS07980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EAW52_RS08030	COG4176	ABC-type proline glycine betaine transport system permease component
EAW52_RS08035	COG0517	IMP dehydrogenase activity
EAW52_RS08035	COG4175	Glycine betaine
EAW52_RS08040	COG1253	flavin adenine dinucleotide binding
EAW52_RS08050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EAW52_RS08055	COG0402	S-adenosylhomocysteine deaminase activity
EAW52_RS08060	COG2205	protein histidine kinase activity
EAW52_RS08080	COG0385	Bile acid
EAW52_RS08110	COG0545	Peptidyl-prolyl cis-trans isomerase
EAW52_RS08125	COG3300	MHYT domain
EAW52_RS08125	COG5001	Diguanylate cyclase
EAW52_RS08130	COG0793	Belongs to the peptidase S41A family
EAW52_RS08135	COG0604	alcohol dehydrogenase
EAW52_RS08135	COG4221	oxidoreductase activity
EAW52_RS08135	COG3321	synthase
EAW52_RS08135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EAW52_RS08145	COG3842	ATPase activity
EAW52_RS08175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EAW52_RS08180	COG1362	aminopeptidase activity
EAW52_RS08190	COG0564	pseudouridine synthase activity
EAW52_RS08200	COG2894	cell division
EAW52_RS08210	COG1560	Kdo2-lipid A biosynthetic process
EAW52_RS08225	COG2853	Lipoprotein
EAW52_RS08245	COG2030	dehydratase
EAW52_RS08250	COG0318	PFAM AMP-dependent synthetase and ligase
EAW52_RS08255	COG1643	Atp-dependent helicase
EAW52_RS08280	COG1917	Cupin 2, conserved barrel domain protein
EAW52_RS08280	COG2207	Transcriptional regulator
EAW52_RS08305	COG2188	Transcriptional regulator
EAW52_RS08340	COG1742	UPF0060 membrane protein
EAW52_RS08345	COG3089	Belongs to the UPF0270 family
EAW52_RS08350	COG1363	Peptidase, m42
EAW52_RS08355	COG0189	ligase activity
EAW52_RS08355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EAW52_RS08360	COG0367	asparagine synthase
EAW52_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS08375	COG0583	DNA-binding transcription factor activity
EAW52_RS08400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EAW52_RS08410	COG3842	ATPase activity
EAW52_RS08425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EAW52_RS08450	COG3162	membrane
EAW52_RS08455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EAW52_RS08485	COG2027	D-alanyl-D-alanine carboxypeptidase
EAW52_RS08505	COG0457	Tetratricopeptide repeat
EAW52_RS08515	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EAW52_RS08525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EAW52_RS08575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAW52_RS08605	COG4191	Histidine kinase
EAW52_RS08605	COG0784	Response regulator, receiver
EAW52_RS08610	COG5001	Diguanylate cyclase
EAW52_RS08615	COG2094	Belongs to the DNA glycosylase MPG family
EAW52_RS08620	COG2124	cytochrome p450
EAW52_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS08695	COG0521	Mo-molybdopterin cofactor biosynthetic process
EAW52_RS08700	COG0303	'Molybdopterin
EAW52_RS08765	COG1201	RNA secondary structure unwinding
EAW52_RS08770	COG4598	ABC transporter
EAW52_RS08795	COG1876	peptidase activity
EAW52_RS08810	COG1595	DNA-templated transcription, initiation
EAW52_RS08815	COG3712	iron ion homeostasis
EAW52_RS08820	COG4772	TonB-dependent receptor
EAW52_RS08825	COG1793	dna ligase
EAW52_RS08835	COG1793	dna ligase
EAW52_RS08835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EAW52_RS08840	COG3300	MHYT domain
EAW52_RS08840	COG5001	Diguanylate cyclase
EAW52_RS08850	COG0243	molybdopterin cofactor binding
EAW52_RS08860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EAW52_RS08875	COG0515	serine threonine protein kinase
EAW52_RS08875	COG2815	serine threonine protein kinase
EAW52_RS08880	COG2223	nitrite transmembrane transporter activity
EAW52_RS08900	COG3707	response regulator
EAW52_RS08905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EAW52_RS08905	COG1116	anion transmembrane transporter activity
EAW52_RS08915	COG0531	amino acid
EAW52_RS08920	COG0625	glutathione transferase activity
EAW52_RS08925	COG0653	protein targeting
EAW52_RS08940	COG3012	SEC-C Motif Domain Protein
EAW52_RS08965	COG1199	ATP-dependent helicase activity
EAW52_RS08970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EAW52_RS08975	COG2116	formate transmembrane transporter activity
EAW52_RS08980	COG2885	chlorophyll binding
EAW52_RS08985	COG0259	pyridoxamine-phosphate oxidase activity
EAW52_RS08990	COG3835	regulator
EAW52_RS09000	COG1929	Belongs to the glycerate kinase type-1 family
EAW52_RS09010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EAW52_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS09040	COG2988	succinylglutamate desuccinylase activity
EAW52_RS09045	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EAW52_RS09050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EAW52_RS09110	COG2226	methyltransferase
EAW52_RS09115	COG0473	3-isopropylmalate dehydrogenase activity
EAW52_RS09140	COG0135	phosphoribosylanthranilate isomerase activity
EAW52_RS09145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EAW52_RS09150	COG0285	dihydrofolate synthase activity
EAW52_RS09160	COG1286	toxin biosynthetic process
EAW52_RS09195	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS09195	COG0446	pyridine nucleotide-disulphide oxidoreductase
EAW52_RS09220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EAW52_RS09225	COG0705	Rhomboid family
EAW52_RS09250	COG3212	peptidase
EAW52_RS09305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EAW52_RS09310	COG1034	ATP synthesis coupled electron transport
EAW52_RS09330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EAW52_RS09335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EAW52_RS09345	COG2153	protein acetylation
EAW52_RS09350	COG2850	peptidyl-arginine hydroxylation
EAW52_RS09360	COG2915	High frequency lysogenization protein hflD homolog
EAW52_RS09365	COG0482	sulfurtransferase activity
EAW52_RS09380	COG0501	Belongs to the peptidase M48B family
EAW52_RS09390	COG0436	Aminotransferase
EAW52_RS09395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EAW52_RS09400	COG0386	Belongs to the glutathione peroxidase family
EAW52_RS09410	COG1956	GAF domain-containing protein
EAW52_RS09445	COG1131	(ABC) transporter
EAW52_RS09450	COG0842	Transport permease protein
EAW52_RS09465	COG2853	Lipoprotein
EAW52_RS09475	COG0745	RESPONSE REGULATOR receiver
EAW52_RS09485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EAW52_RS09490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EAW52_RS09515	COG2116	formate transmembrane transporter activity
EAW52_RS09525	COG4172	Belongs to the ABC transporter superfamily
EAW52_RS09530	COG4239	(ABC) transporter, permease
EAW52_RS09535	COG4174	ABC transporter (Permease)
EAW52_RS09540	COG4166	transmembrane transport
EAW52_RS09545	COG1388	LysM domain
EAW52_RS09545	COG0741	lytic transglycosylase activity
EAW52_RS09560	COG0328	RNA-DNA hybrid ribonuclease activity
EAW52_RS09570	COG1024	Enoyl-CoA hydratase
EAW52_RS09580	COG2816	NAD+ diphosphatase activity
EAW52_RS09590	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS09600	COG0616	signal peptide processing
EAW52_RS09605	COG0604	alcohol dehydrogenase
EAW52_RS09615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EAW52_RS09630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EAW52_RS09635	COG4807	Protein conserved in bacteria
EAW52_RS09660	COG2226	methyltransferase
EAW52_RS09670	COG3547	Transposase (IS116 IS110 IS902 family)
EAW52_RS09715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EAW52_RS09720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EAW52_RS09725	COG1196	nuclear chromosome segregation
EAW52_RS09730	COG3115	cell septum assembly
EAW52_RS09750	COG2186	Transcriptional regulator
EAW52_RS09760	COG1879	ABC-type sugar transport system periplasmic component
EAW52_RS09765	COG1129	ABC transporter
EAW52_RS09770	COG1172	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS09780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EAW52_RS09785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EAW52_RS09790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EAW52_RS09795	COG1595	DNA-templated transcription, initiation
EAW52_RS09850	COG3123	guanosine phosphorylase activity
EAW52_RS09890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EAW52_RS09895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EAW52_RS09900	COG0215	cysteine-tRNA ligase activity
EAW52_RS09905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EAW52_RS09925	COG0544	peptidyl-prolyl cis-trans isomerase activity
EAW52_RS09940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EAW52_RS09955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS09960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EAW52_RS09970	COG0542	response to heat
EAW52_RS10015	COG0840	transmembrane signaling receptor activity
EAW52_RS10040	COG3091	SprT-like family
EAW52_RS10065	COG0791	NLP P60 protein
EAW52_RS10070	COG0791	NLP P60 protein
EAW52_RS10085	COG2010	Cytochrome c
EAW52_RS10085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EAW52_RS10090	COG2080	2 iron, 2 sulfur cluster binding
EAW52_RS10095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EAW52_RS10095	COG2010	Cytochrome c
EAW52_RS10125	COG0778	Nitroreductase
EAW52_RS10140	COG1492	cobalamin metabolic process
EAW52_RS10160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EAW52_RS10215	COG0121	glutamine amidotransferase
EAW52_RS10265	COG1278	Cold shock
EAW52_RS10275	COG3781	membrane
EAW52_RS10295	COG0625	glutathione transferase activity
EAW52_RS10335	COG0747	negative chemotaxis
EAW52_RS10350	COG0483	inositol monophosphate 1-phosphatase activity
EAW52_RS10360	COG0217	transcriptional regulatory protein
EAW52_RS10380	COG0517	IMP dehydrogenase activity
EAW52_RS10395	COG0583	DNA-binding transcription factor activity
EAW52_RS10410	COG2814	Major facilitator Superfamily
EAW52_RS10415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EAW52_RS10440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EAW52_RS10445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EAW52_RS10445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EAW52_RS10450	COG2832	Protein of unknown function (DUF454)
EAW52_RS10460	COG0514	ATP-dependent DNA helicase (RecQ)
EAW52_RS10465	COG1846	Transcriptional regulator
EAW52_RS10475	COG1752	Esterase of the alpha-beta hydrolase superfamily
EAW52_RS10485	COG1278	Cold shock
EAW52_RS10490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EAW52_RS10495	COG0542	response to heat
EAW52_RS10500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EAW52_RS10505	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EAW52_RS10510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EAW52_RS10525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EAW52_RS10530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EAW52_RS10545	COG0435	Glutathione S-transferase
EAW52_RS10550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EAW52_RS10560	COG2168	tRNA wobble position uridine thiolation
EAW52_RS10615	COG0582	viral genome integration into host DNA
EAW52_RS11030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EAW52_RS11040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EAW52_RS11045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EAW52_RS11055	COG0072	phenylalanine-tRNA ligase activity
EAW52_RS11060	COG0776	regulation of translation
EAW52_RS11115	COG0306	phosphate transporter
EAW52_RS11120	COG0720	synthase
EAW52_RS11130	COG1132	(ABC) transporter
EAW52_RS11135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EAW52_RS11145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EAW52_RS11165	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EAW52_RS11170	COG0243	molybdopterin cofactor binding
EAW52_RS11170	COG3383	formate dehydrogenase (NAD+) activity
EAW52_RS11175	COG3383	formate dehydrogenase (NAD+) activity
EAW52_RS11175	COG0243	molybdopterin cofactor binding
EAW52_RS11180	COG0437	4 iron, 4 sulfur cluster binding
EAW52_RS11185	COG2864	formate dehydrogenase
EAW52_RS11195	COG0402	S-adenosylhomocysteine deaminase activity
EAW52_RS11205	COG3813	Protein conserved in bacteria
EAW52_RS11215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EAW52_RS11245	COG1653	transport
EAW52_RS11250	COG1175	transmembrane transport
EAW52_RS11255	COG0395	ABC-type sugar transport system, permease component
EAW52_RS11285	COG1737	Transcriptional regulator
EAW52_RS11300	COG0800	Aldolase
EAW52_RS11310	COG3135	benzoate transporter
EAW52_RS11325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS11330	COG0625	glutathione transferase activity
EAW52_RS11335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EAW52_RS11355	COG1132	(ABC) transporter
EAW52_RS11380	COG1968	undecaprenyl-diphosphatase activity
EAW52_RS11390	COG0488	(ABC) transporter
EAW52_RS11405	COG2813	Specifically methylates the guanine in position
EAW52_RS11495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EAW52_RS11500	COG0708	Exodeoxyribonuclease III
EAW52_RS11505	COG0729	surface antigen
EAW52_RS11535	COG1538	Outer membrane efflux protein
EAW52_RS11550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EAW52_RS11575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EAW52_RS11585	COG0392	lysyltransferase activity
EAW52_RS11590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EAW52_RS11595	COG3568	Endonuclease Exonuclease Phosphatase
EAW52_RS11620	COG1640	4-alpha-glucanotransferase
EAW52_RS11625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EAW52_RS11630	COG0297	glycogen (starch) synthase activity
EAW52_RS11640	COG3851	Histidine kinase
EAW52_RS11645	COG2197	response regulator
EAW52_RS11665	COG2201	protein-glutamate methylesterase activity
EAW52_RS11675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EAW52_RS11685	COG0784	Response regulator, receiver
EAW52_RS11685	COG2198	Histidine kinase
EAW52_RS11685	COG0643	Histidine kinase
EAW52_RS11695	COG0745	RESPONSE REGULATOR receiver
EAW52_RS11700	COG0840	transmembrane signaling receptor activity
EAW52_RS11705	COG2011	ABC-type metal ion transport system permease component
EAW52_RS11710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EAW52_RS11715	COG1464	Belongs to the NlpA lipoprotein family
EAW52_RS11735	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EAW52_RS11745	COG1120	ATPase activity
EAW52_RS11760	COG1126	abc transporter atp-binding protein
EAW52_RS11765	COG0765	amino acid transport
EAW52_RS11770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EAW52_RS11785	COG2610	gluconate transmembrane transporter activity
EAW52_RS11795	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EAW52_RS11800	COG0251	oxidation-reduction process
EAW52_RS11805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EAW52_RS11840	COG0667	Aldo Keto reductase
EAW52_RS11845	COG0583	DNA-binding transcription factor activity
EAW52_RS11855	COG0318	PFAM AMP-dependent synthetase and ligase
EAW52_RS11865	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS11870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EAW52_RS11875	COG1024	Enoyl-CoA hydratase
EAW52_RS11905	COG0640	Transcriptional regulator
EAW52_RS11910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EAW52_RS11920	COG0431	NADPH-dependent FMN reductase
EAW52_RS11930	COG4251	negative regulation of phosphorylation
EAW52_RS11935	COG1113	amino acid transport
EAW52_RS11940	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS11970	COG2721	sulfolactate sulfo-lyase activity
EAW52_RS11975	COG1312	Catalyzes the dehydration of D-mannonate
EAW52_RS11980	COG0246	Mannitol dehydrogenase
EAW52_RS11985	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EAW52_RS11990	COG2271	Major facilitator Superfamily
EAW52_RS11995	COG1063	alcohol dehydrogenase
EAW52_RS12000	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAW52_RS12020	COG4774	siderophore transport
EAW52_RS12035	COG0642	Histidine kinase
EAW52_RS12050	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
EAW52_RS12055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EAW52_RS12065	COG1408	metallophosphoesterase
EAW52_RS12070	COG4221	oxidoreductase activity
EAW52_RS12075	COG0437	4 iron, 4 sulfur cluster binding
EAW52_RS12085	COG0025	NhaP-type Na H and K H
EAW52_RS12100	COG5001	Diguanylate cyclase
EAW52_RS12100	COG3706	GGDEF domain
EAW52_RS12100	COG2203	Gaf domain
EAW52_RS12100	COG4251	negative regulation of phosphorylation
EAW52_RS12115	COG2733	membrane
EAW52_RS12120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EAW52_RS12140	COG0477	Major facilitator Superfamily
EAW52_RS12150	COG2995	paraquat-inducible protein a
EAW52_RS12155	COG2995	paraquat-inducible protein a
EAW52_RS12160	COG3008	intermembrane lipid transfer
EAW52_RS12160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EAW52_RS12185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EAW52_RS12200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EAW52_RS12220	COG1024	Enoyl-CoA hydratase
EAW52_RS12225	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS12240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EAW52_RS12250	COG1024	Enoyl-CoA hydratase
EAW52_RS12250	COG1250	3-hydroxyacyl-CoA dehydrogenase
EAW52_RS12260	COG0840	transmembrane signaling receptor activity
EAW52_RS12265	COG0477	Major facilitator Superfamily
EAW52_RS12275	COG2211	Major facilitator Superfamily
EAW52_RS12280	COG1621	beta-fructofuranosidase activity
EAW52_RS12300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EAW52_RS12315	COG2205	protein histidine kinase activity
EAW52_RS12320	COG0745	RESPONSE REGULATOR receiver
EAW52_RS12350	COG2828	Protein conserved in bacteria
EAW52_RS12355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EAW52_RS12360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EAW52_RS12365	COG0583	DNA-binding transcription factor activity
EAW52_RS12375	COG3384	dioxygenase
EAW52_RS12385	COG2079	MmgE PrpD family protein
EAW52_RS12390	COG0372	Belongs to the citrate synthase family
EAW52_RS12400	COG1802	Transcriptional regulator
EAW52_RS12405	COG0784	Response regulator, receiver
EAW52_RS12405	COG2205	protein histidine kinase activity
EAW52_RS12420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EAW52_RS12430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EAW52_RS12440	COG4221	oxidoreductase activity
EAW52_RS12445	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EAW52_RS12450	COG2814	Major facilitator Superfamily
EAW52_RS12460	COG0840	transmembrane signaling receptor activity
EAW52_RS12485	COG2267	carboxylic ester hydrolase activity
EAW52_RS12510	COG0679	Auxin Efflux Carrier
EAW52_RS12520	COG4792	protein secretion
EAW52_RS12530	COG4794	Type iii secretion
EAW52_RS12535	COG4790	Type iii secretion
EAW52_RS12540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EAW52_RS12565	COG4669	(LipO)protein
EAW52_RS12595	COG4964	Belongs to the GSP D family
EAW52_RS12600	COG4789	Type iii secretion
EAW52_RS12625	COG2267	carboxylic ester hydrolase activity
EAW52_RS12635	COG4221	oxidoreductase activity
EAW52_RS12640	COG2207	Transcriptional regulator
EAW52_RS12645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EAW52_RS12655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EAW52_RS12670	COG4191	Histidine kinase
EAW52_RS12670	COG0784	Response regulator, receiver
EAW52_RS12685	COG0673	inositol 2-dehydrogenase activity
EAW52_RS12705	COG3916	Acyl-homoserine-lactone synthase
EAW52_RS12715	COG0861	Integral membrane protein TerC family
EAW52_RS12720	COG0708	Exodeoxyribonuclease III
EAW52_RS12730	COG1132	(ABC) transporter
EAW52_RS12735	COG0156	8-amino-7-oxononanoate synthase activity
EAW52_RS12740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EAW52_RS12750	COG0318	PFAM AMP-dependent synthetase and ligase
EAW52_RS12760	COG0456	acetyltransferase
EAW52_RS12770	COG1213	nucleotidyl transferase
EAW52_RS12775	COG0795	lipopolysaccharide-transporting ATPase activity
EAW52_RS12785	COG1183	phosphatidylcholine synthase activity
EAW52_RS12820	COG2186	Transcriptional regulator
EAW52_RS12825	COG0444	Belongs to the ABC transporter superfamily
EAW52_RS12830	COG4608	Belongs to the ABC transporter superfamily
EAW52_RS12835	COG0747	negative chemotaxis
EAW52_RS12840	COG0601	transmembrane transport
EAW52_RS12845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAW52_RS12860	COG0076	glutamate decarboxylase activity
EAW52_RS12865	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EAW52_RS12890	COG4191	Histidine kinase
EAW52_RS12890	COG0784	Response regulator, receiver
EAW52_RS12910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EAW52_RS12915	COG0784	Response regulator, receiver
EAW52_RS12935	COG0492	ferredoxin-NADP+ reductase activity
EAW52_RS12940	COG3685	Protein conserved in bacteria
EAW52_RS12955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EAW52_RS12965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EAW52_RS12965	COG3608	succinylglutamate desuccinylase aspartoacylase
EAW52_RS12990	COG2207	Transcriptional regulator
EAW52_RS13040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EAW52_RS13045	COG0242	peptide deformylase activity
EAW52_RS13055	COG1278	Cold shock
EAW52_RS13065	COG2133	pyrroloquinoline quinone binding
EAW52_RS13080	COG0840	transmembrane signaling receptor activity
EAW52_RS13085	COG1201	RNA secondary structure unwinding
EAW52_RS13090	COG0477	Major facilitator Superfamily
EAW52_RS13100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EAW52_RS13105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EAW52_RS13115	COG0513	Belongs to the DEAD box helicase family
EAW52_RS13195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EAW52_RS13200	COG0009	L-threonylcarbamoyladenylate synthase
EAW52_RS13210	COG2917	probably involved in intracellular septation
EAW52_RS13215	COG0745	RESPONSE REGULATOR receiver
EAW52_RS13230	COG0778	Nitroreductase
EAW52_RS13240	COG0500	methyltransferase
EAW52_RS13255	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EAW52_RS13260	COG3214	Protein conserved in bacteria
EAW52_RS13270	COG0583	DNA-binding transcription factor activity
EAW52_RS13280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EAW52_RS13300	COG1215	transferase activity, transferring glycosyl groups
EAW52_RS13305	COG1215	transferase activity, transferring glycosyl groups
EAW52_RS13310	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EAW52_RS13315	COG0457	Tetratricopeptide repeat
EAW52_RS13315	COG3118	belongs to the thioredoxin family
EAW52_RS13320	COG2130	NADP-dependent
EAW52_RS13325	COG2194	sulfuric ester hydrolase activity
EAW52_RS13360	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EAW52_RS13390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EAW52_RS13405	COG1181	Belongs to the D-alanine--D-alanine ligase family
EAW52_RS13425	COG0668	transmembrane transport
EAW52_RS13440	COG1175	transmembrane transport
EAW52_RS13450	COG3842	ATPase activity
EAW52_RS13455	COG0246	Mannitol dehydrogenase
EAW52_RS13460	COG1070	Carbohydrate kinase
EAW52_RS13470	COG0673	inositol 2-dehydrogenase activity
EAW52_RS13475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EAW52_RS13485	COG3130	regulation of translation
EAW52_RS13490	COG0167	dihydroorotate dehydrogenase activity
EAW52_RS13505	COG0784	Response regulator, receiver
EAW52_RS13505	COG4191	Histidine kinase
EAW52_RS13515	COG4251	negative regulation of phosphorylation
EAW52_RS13520	COG0596	Alpha beta hydrolase
EAW52_RS13530	COG1368	sulfuric ester hydrolase activity
EAW52_RS13540	COG0714	Associated with various cellular activities
EAW52_RS13555	COG2304	oxidoreductase activity
EAW52_RS13560	COG2304	oxidoreductase activity
EAW52_RS13570	COG0420	3'-5' exonuclease activity
EAW52_RS13580	COG0308	aminopeptidase N
EAW52_RS13590	COG3139	Protein of unknown function (DUF1315)
EAW52_RS13645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EAW52_RS13655	COG0835	chemotaxis
EAW52_RS13665	COG1192	Involved in chromosome partitioning
EAW52_RS13675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EAW52_RS13680	COG2201	protein-glutamate methylesterase activity
EAW52_RS13685	COG2198	Histidine kinase
EAW52_RS13685	COG0784	Response regulator, receiver
EAW52_RS13685	COG0643	Histidine kinase
EAW52_RS13720	COG2032	superoxide dismutase activity
EAW52_RS13730	COG1684	flagellar biosynthetic protein fliR
EAW52_RS13735	COG1987	bacterial-type flagellum assembly
EAW52_RS13800	COG1677	Flagellar hook-basal body complex protein FliE
EAW52_RS13835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EAW52_RS13850	COG0776	regulation of translation
EAW52_RS13860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EAW52_RS13865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EAW52_RS13875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EAW52_RS13895	COG0833	amino acid
EAW52_RS13945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EAW52_RS13955	COG0859	PFAM glycosyl transferase family 9
EAW52_RS13955	COG0457	Tetratricopeptide repeat
EAW52_RS13980	COG1706	bacterial-type flagellum-dependent cell motility
EAW52_RS13985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EAW52_RS14000	COG1749	Flagellar hook protein flgE
EAW52_RS14015	COG1815	bacterial-type flagellum-dependent cell motility
EAW52_RS14025	COG0784	Response regulator, receiver
EAW52_RS14025	COG0835	chemotaxis
EAW52_RS14045	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EAW52_RS14050	COG0477	Major facilitator Superfamily
EAW52_RS14065	COG1082	Xylose isomerase domain protein TIM barrel
EAW52_RS14100	COG2239	Acts as a magnesium transporter
EAW52_RS14115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EAW52_RS14125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EAW52_RS14130	COG0402	S-adenosylhomocysteine deaminase activity
EAW52_RS14135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EAW52_RS14140	COG0546	phosphoglycolate phosphatase activity
EAW52_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS14155	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EAW52_RS14165	COG2807	transmembrane transport
EAW52_RS14170	COG0628	permease
EAW52_RS14180	COG0596	Alpha beta hydrolase
EAW52_RS14205	COG2205	protein histidine kinase activity
EAW52_RS14205	COG0784	Response regulator, receiver
EAW52_RS14205	COG5002	protein histidine kinase activity
EAW52_RS14240	COG3217	Mosc domain protein beta barrel domain protein
EAW52_RS14240	COG0633	Ferredoxin
EAW52_RS14245	COG0835	chemotaxis
EAW52_RS14245	COG0784	Response regulator, receiver
EAW52_RS14250	COG0717	Belongs to the dCTP deaminase family
EAW52_RS14255	COG0489	protein tyrosine kinase activity
EAW52_RS14270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS14275	COG1120	ATPase activity
EAW52_RS14285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EAW52_RS14295	COG0137	argininosuccinate synthase activity
EAW52_RS14305	COG0418	dihydroorotase activity
EAW52_RS14375	COG1053	succinate dehydrogenase
EAW52_RS14380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EAW52_RS14385	COG2009	succinate dehydrogenase
EAW52_RS14405	COG0668	transmembrane transport
EAW52_RS14420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EAW52_RS14455	COG0189	ligase activity
EAW52_RS14460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EAW52_RS14465	COG0175	sulfate reduction
EAW52_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS14535	COG1376	ErfK ybiS ycfS ynhG family protein
EAW52_RS14550	COG4181	ATPase activity
EAW52_RS14555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EAW52_RS14575	COG0084	hydrolase, TatD family'
EAW52_RS14600	COG0714	Associated with various cellular activities
EAW52_RS14620	COG4302	ethanolamine ammonia-lyase activity
EAW52_RS14640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS14680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EAW52_RS14695	COG0084	hydrolase, TatD family'
EAW52_RS14710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EAW52_RS14715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EAW52_RS14725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EAW52_RS14750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EAW52_RS14755	COG1399	metal-binding, possibly nucleic acid-binding protein
EAW52_RS14760	COG0424	maF-like protein
EAW52_RS14765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EAW52_RS14765	COG0616	signal peptide processing
EAW52_RS14770	COG0546	phosphoglycolate phosphatase activity
EAW52_RS14780	COG1530	ribonuclease E activity
EAW52_RS14785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EAW52_RS14790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EAW52_RS14795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EAW52_RS14800	COG2835	tetraacyldisaccharide 4'-kinase activity
EAW52_RS14805	COG1663	tetraacyldisaccharide 4'-kinase activity
EAW52_RS14810	COG0848	biopolymer transport protein
EAW52_RS14815	COG0811	peptide transport
EAW52_RS14825	COG1136	(ABC) transporter
EAW52_RS14830	COG4591	ABC-type transport system involved in lipoprotein release permease component
EAW52_RS14840	COG4591	ABC-type transport system involved in lipoprotein release permease component
EAW52_RS14855	COG0584	glycerophosphoryl diester phosphodiesterase
EAW52_RS14870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EAW52_RS14925	COG1024	Enoyl-CoA hydratase
EAW52_RS14925	COG1250	3-hydroxyacyl-CoA dehydrogenase
EAW52_RS14930	COG0589	response to stress
EAW52_RS14935	COG0488	(ABC) transporter
EAW52_RS14945	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EAW52_RS14955	COG3639	organic phosphonate transmembrane transporter activity
EAW52_RS15000	COG5001	Diguanylate cyclase
EAW52_RS15025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EAW52_RS15030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EAW52_RS15045	COG1054	Belongs to the UPF0176 family
EAW52_RS15050	COG0271	Belongs to the BolA IbaG family
EAW52_RS15065	COG2249	NAD(P)H dehydrogenase (quinone) activity
EAW52_RS15070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EAW52_RS15075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EAW52_RS15080	COG1845	cytochrome c oxidase, subunit III
EAW52_RS15085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EAW52_RS15090	COG0109	protoheme IX farnesyltransferase activity
EAW52_RS15110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS15110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EAW52_RS15115	COG0656	L-ascorbic acid biosynthetic process
EAW52_RS15135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EAW52_RS15155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EAW52_RS15165	COG2226	methyltransferase
EAW52_RS15205	COG1381	Involved in DNA repair and RecF pathway recombination
EAW52_RS15210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EAW52_RS15230	COG0481	GTPase activity
EAW52_RS15235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EAW52_RS15270	COG0354	folic acid binding
EAW52_RS15280	COG0642	Histidine kinase
EAW52_RS15305	COG3180	Ammonia monooxygenase
EAW52_RS15320	COG1801	Protein of unknown function DUF72
EAW52_RS15335	COG3237	CsbD-like
EAW52_RS15380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EAW52_RS15395	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS15400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EAW52_RS15410	COG3706	GGDEF domain
EAW52_RS15425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EAW52_RS15435	COG1607	acyl-coa hydrolase
EAW52_RS15445	COG0336	Belongs to the RNA methyltransferase TrmD family
EAW52_RS15460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EAW52_RS15470	COG0477	Major facilitator Superfamily
EAW52_RS15475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EAW52_RS15485	COG0494	nUDIX hydrolase
EAW52_RS15495	COG3034	peptidoglycan biosynthetic process
EAW52_RS15515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EAW52_RS15525	COG2226	methyltransferase
EAW52_RS15535	COG1278	Cold shock
EAW52_RS15570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EAW52_RS15575	COG1116	anion transmembrane transporter activity
EAW52_RS15590	COG0439	Biotin carboxylase
EAW52_RS15610	COG0584	glycerophosphoryl diester phosphodiesterase
EAW52_RS15660	COG3706	GGDEF domain
EAW52_RS15690	COG1294	oxidase, subunit
EAW52_RS15705	COG4191	Histidine kinase
EAW52_RS15705	COG0784	Response regulator, receiver
EAW52_RS15710	COG2135	peptidase activity
EAW52_RS15725	COG1366	Belongs to the anti-sigma-factor antagonist family
EAW52_RS15730	COG1366	Belongs to the anti-sigma-factor antagonist family
EAW52_RS15735	COG2172	sigma factor antagonist activity
EAW52_RS15745	COG0784	Response regulator, receiver
EAW52_RS15745	COG5002	protein histidine kinase activity
EAW52_RS15750	COG2205	protein histidine kinase activity
EAW52_RS15770	COG0517	IMP dehydrogenase activity
EAW52_RS15820	COG2197	response regulator
EAW52_RS15830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EAW52_RS15835	COG2271	Major facilitator Superfamily
EAW52_RS15845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EAW52_RS15850	COG1074	ATP-dependent DNA helicase activity
EAW52_RS15855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EAW52_RS15870	COG4221	oxidoreductase activity
EAW52_RS15875	COG2186	Transcriptional regulator
EAW52_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS15885	COG0179	Fumarylacetoacetate (FAA) hydrolase
EAW52_RS15890	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS15905	COG3254	rhamnose metabolic process
EAW52_RS15915	COG0738	Major facilitator superfamily
EAW52_RS15950	COG0596	Alpha beta hydrolase
EAW52_RS15960	COG1597	lipid kinase activity
EAW52_RS15965	COG3204	pilus organization
EAW52_RS16010	COG1946	Acyl-CoA thioesterase
EAW52_RS16025	COG4191	Histidine kinase
EAW52_RS16025	COG0784	Response regulator, receiver
EAW52_RS16030	COG3932	Exopolysaccharide synthesis, ExoD
EAW52_RS16035	COG0123	including yeast histone deacetylase and acetoin utilization protein
EAW52_RS16055	COG0513	Belongs to the DEAD box helicase family
EAW52_RS16070	COG1522	sequence-specific DNA binding
EAW52_RS16080	COG3416	Protein conserved in bacteria
EAW52_RS16085	COG0673	inositol 2-dehydrogenase activity
EAW52_RS16090	COG1335	isochorismatase
EAW52_RS16110	COG3956	TIGRFAM MazG family protein
EAW52_RS16115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EAW52_RS16130	COG5002	protein histidine kinase activity
EAW52_RS16130	COG2205	protein histidine kinase activity
EAW52_RS16130	COG0784	Response regulator, receiver
EAW52_RS16140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EAW52_RS16185	COG3158	transport of potassium into the cell
EAW52_RS16195	COG0803	Belongs to the bacterial solute-binding protein 9 family
EAW52_RS16215	COG0789	Transcriptional regulator
EAW52_RS16240	COG0583	DNA-binding transcription factor activity
EAW52_RS16260	COG3148	PFAM DTW domain containing protein
EAW52_RS16270	COG1611	Belongs to the LOG family
EAW52_RS16285	COG1546	Belongs to the CinA family
EAW52_RS16290	COG1609	Transcriptional regulator
EAW52_RS16300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAW52_RS16330	COG0727	PFAM Uncharacterised protein family (UPF0153)
EAW52_RS16335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EAW52_RS16340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EAW52_RS16360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EAW52_RS16365	COG0585	pseudouridine synthase activity
EAW52_RS16370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EAW52_RS16380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EAW52_RS16385	COG0583	DNA-binding transcription factor activity
EAW52_RS16395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EAW52_RS16405	COG0148	phosphopyruvate hydratase activity
EAW52_RS16410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EAW52_RS16420	COG0037	tRNA processing
EAW52_RS16425	COG0825	malonyl-CoA metabolic process
EAW52_RS16440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EAW52_RS16465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EAW52_RS16475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EAW52_RS16485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EAW52_RS16495	COG0528	UMP kinase activity
EAW52_RS16510	COG0024	Methionine aminopeptidase
EAW52_RS16520	COG0436	Aminotransferase
EAW52_RS16525	COG0025	NhaP-type Na H and K H
EAW52_RS16540	COG3591	Belongs to the peptidase S1B family
EAW52_RS16540	COG1864	DNA RNA non-specific endonuclease
EAW52_RS16545	COG1393	Belongs to the ArsC family
EAW52_RS16565	COG2166	iron-sulfur cluster assembly
EAW52_RS16585	COG1609	Transcriptional regulator
EAW52_RS16590	COG0129	dihydroxy-acid dehydratase activity
EAW52_RS16600	COG2814	Major facilitator Superfamily
EAW52_RS16600	COG0477	Major facilitator Superfamily
EAW52_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS16610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EAW52_RS16610	COG0519	Catalyzes the synthesis of GMP from XMP
EAW52_RS16620	COG4774	siderophore transport
EAW52_RS16625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EAW52_RS16630	COG1570	exodeoxyribonuclease VII activity
EAW52_RS16635	COG2999	glutathione oxidoreductase activity
EAW52_RS16640	COG0739	heme binding
EAW52_RS16655	COG1846	Transcriptional regulator
EAW52_RS16660	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS16665	COG0625	glutathione transferase activity
EAW52_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS16695	COG2610	gluconate transmembrane transporter activity
EAW52_RS16705	COG1250	3-hydroxyacyl-CoA dehydrogenase
EAW52_RS16715	COG0436	Aminotransferase
EAW52_RS16720	COG1160	GTP binding
EAW52_RS16735	COG0124	histidyl-tRNA synthetase
EAW52_RS16745	COG1426	Protein conserved in bacteria
EAW52_RS16755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EAW52_RS16795	COG1104	cysteine desulfurase activity
EAW52_RS16815	COG2969	positive regulation of protein catabolic process
EAW52_RS16820	COG0625	glutathione transferase activity
EAW52_RS16825	COG2857	Cytochrome c1
EAW52_RS16830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EAW52_RS16835	COG0723	plastoquinol--plastocyanin reductase activity
EAW52_RS16850	COG0667	Aldo Keto reductase
EAW52_RS16855	COG1515	deoxyribonuclease V activity
EAW52_RS16860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EAW52_RS16870	COG2945	thiolester hydrolase activity
EAW52_RS16895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EAW52_RS16900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EAW52_RS16910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EAW52_RS16935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EAW52_RS16940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EAW52_RS16945	COG1127	ABC transporter
EAW52_RS16960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EAW52_RS16965	COG1137	ATPase activity
EAW52_RS16985	COG1660	Displays ATPase and GTPase activities
EAW52_RS17000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EAW52_RS17005	COG0312	modulator of DNA gyrase
EAW52_RS17015	COG0312	modulator of DNA gyrase
EAW52_RS17020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EAW52_RS17030	COG1530	ribonuclease E activity
EAW52_RS17035	COG0424	maF-like protein
EAW52_RS17045	COG1792	Involved in formation and maintenance of cell shape
EAW52_RS17050	COG1077	Cell shape determining protein MreB Mrl
EAW52_RS17055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EAW52_RS17065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EAW52_RS17070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EAW52_RS17075	COG2721	sulfolactate sulfo-lyase activity
EAW52_RS17085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EAW52_RS17090	COG2186	Transcriptional regulator
EAW52_RS17095	COG4178	(ABC) transporter
EAW52_RS17100	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EAW52_RS17105	COG3852	Histidine kinase
EAW52_RS17115	COG0747	negative chemotaxis
EAW52_RS17120	COG0747	negative chemotaxis
EAW52_RS17125	COG0747	negative chemotaxis
EAW52_RS17130	COG0747	negative chemotaxis
EAW52_RS17135	COG0601	transmembrane transport
EAW52_RS17140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAW52_RS17145	COG0444	Belongs to the ABC transporter superfamily
EAW52_RS17150	COG4608	Belongs to the ABC transporter superfamily
EAW52_RS17165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EAW52_RS17195	COG3276	selenocysteine insertion sequence binding
EAW52_RS17200	COG1921	L-seryl-tRNASec selenium transferase activity
EAW52_RS17210	COG2864	formate dehydrogenase
EAW52_RS17215	COG0437	4 iron, 4 sulfur cluster binding
EAW52_RS17220	COG0243	molybdopterin cofactor binding
EAW52_RS17220	COG3383	formate dehydrogenase (NAD+) activity
EAW52_RS17225	COG3383	formate dehydrogenase (NAD+) activity
EAW52_RS17225	COG0243	molybdopterin cofactor binding
EAW52_RS17230	COG0659	secondary active sulfate transmembrane transporter activity
EAW52_RS17235	COG0589	response to stress
EAW52_RS17245	COG2271	Major facilitator Superfamily
EAW52_RS17250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EAW52_RS17255	COG4774	siderophore transport
EAW52_RS17260	COG3128	pkhd-type hydroxylase
EAW52_RS17270	COG0019	diaminopimelate decarboxylase activity
EAW52_RS17305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EAW52_RS17305	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EAW52_RS17305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EAW52_RS17310	COG1105	Belongs to the carbohydrate kinase PfkB family
EAW52_RS17320	COG1609	Transcriptional regulator
EAW52_RS17325	COG0084	hydrolase, TatD family'
EAW52_RS17345	COG0463	Glycosyl transferase, family 2
EAW52_RS17375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EAW52_RS17380	COG0237	dephospho-CoA kinase activity
EAW52_RS17400	COG1252	NADH dehydrogenase
EAW52_RS17455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS17495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EAW52_RS17500	COG1047	Peptidyl-prolyl cis-trans
EAW52_RS17505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EAW52_RS17510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EAW52_RS17515	COG0196	riboflavin kinase activity
EAW52_RS17525	COG0268	Binds directly to 16S ribosomal RNA
EAW52_RS17530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EAW52_RS17540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EAW52_RS17550	COG0142	geranyltranstransferase activity
EAW52_RS17560	COG0545	Peptidyl-prolyl cis-trans isomerase
EAW52_RS17580	COG1067	ATP-dependent peptidase activity
EAW52_RS17590	COG5006	permease, DMT superfamily
EAW52_RS17595	COG3265	gluconokinase activity
EAW52_RS17600	COG0488	(ABC) transporter
EAW52_RS17615	COG0523	cobalamin synthesis protein
EAW52_RS17620	COG2879	small protein
EAW52_RS17625	COG1966	Carbon starvation protein
EAW52_RS17665	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS17670	COG2813	Specifically methylates the guanine in position
EAW52_RS17680	COG2066	Belongs to the glutaminase family
EAW52_RS17695	COG1294	oxidase, subunit
EAW52_RS17700	COG1271	oxidase subunit
EAW52_RS17715	COG3387	PFAM Glycoside hydrolase 15-related
EAW52_RS17720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EAW52_RS17725	COG3180	Ammonia monooxygenase
EAW52_RS17730	COG1643	Atp-dependent helicase
EAW52_RS17750	COG1522	sequence-specific DNA binding
EAW52_RS17760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EAW52_RS17760	COG2010	Cytochrome c
EAW52_RS17785	COG0371	Dehydrogenase
EAW52_RS17795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EAW52_RS17800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EAW52_RS17805	COG1132	(ABC) transporter
EAW52_RS17810	COG1132	(ABC) transporter
EAW52_RS17825	COG0352	thiamine-phosphate diphosphorylase activity
EAW52_RS17830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EAW52_RS17850	COG1702	phosphate starvation-inducible protein PhoH
EAW52_RS17855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EAW52_RS17860	COG4535	Mg2 and Co2 transporter CorC
EAW52_RS17870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EAW52_RS17880	COG0495	leucyl-tRNA aminoacylation
EAW52_RS17900	COG2951	lytic endotransglycosylase activity
EAW52_RS17910	COG0321	lipoyl(octanoyl) transferase activity
EAW52_RS17915	COG2921	Belongs to the UPF0250 family
EAW52_RS17920	COG1686	Belongs to the peptidase S11 family
EAW52_RS17930	COG2951	lytic endotransglycosylase activity
EAW52_RS17935	COG0772	Belongs to the SEDS family
EAW52_RS17940	COG0768	penicillin binding
EAW52_RS17945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EAW52_RS17960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EAW52_RS17965	COG0586	Pfam SNARE associated Golgi protein
EAW52_RS18000	COG3150	esterase
EAW52_RS18005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EAW52_RS18015	COG0494	nUDIX hydrolase
EAW52_RS18035	COG1538	Outer membrane efflux protein
EAW52_RS18040	COG1519	Transferase
EAW52_RS18045	COG0583	DNA-binding transcription factor activity
EAW52_RS18060	COG0667	Aldo Keto reductase
EAW52_RS18070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EAW52_RS18070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EAW52_RS18085	COG1132	(ABC) transporter
EAW52_RS18120	COG2192	nodulation
EAW52_RS18145	COG0438	transferase activity, transferring glycosyl groups
EAW52_RS18150	COG0859	PFAM glycosyl transferase family 9
EAW52_RS18155	COG0859	PFAM glycosyl transferase family 9
EAW52_RS18185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EAW52_RS18195	COG3264	Mechanosensitive ion channel
EAW52_RS18195	COG1196	nuclear chromosome segregation
EAW52_RS18200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EAW52_RS18205	COG0583	DNA-binding transcription factor activity
EAW52_RS18210	COG2814	Major facilitator Superfamily
EAW52_RS18215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EAW52_RS18220	COG0493	'glutamate synthase
EAW52_RS18225	COG0069	glutamate synthase activity
EAW52_RS18225	COG0067	glutamate synthase
EAW52_RS18225	COG0070	glutamate synthase
EAW52_RS18275	COG0281	malic enzyme
EAW52_RS18285	COG0254	rRNA binding
EAW52_RS18290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EAW52_RS18295	COG0018	arginyl-trna synthetase
EAW52_RS18305	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EAW52_RS18310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EAW52_RS18340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EAW52_RS18345	COG0140	phosphoribosyl-ATP diphosphatase activity
EAW52_RS18355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EAW52_RS18370	COG2943	transferase activity, transferring hexosyl groups
EAW52_RS18375	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EAW52_RS18400	COG1881	PFAM PEBP family protein
EAW52_RS18425	COG2177	Part of the ABC transporter FtsEX involved in
EAW52_RS18430	COG2884	Cell division ATP-binding protein ftsE
EAW52_RS18435	COG0552	protein localization to endoplasmic reticulum
EAW52_RS18440	COG0612	Peptidase, M16
EAW52_RS18445	COG0612	Peptidase, M16
EAW52_RS18450	COG0742	ribosomal rna small subunit methyltransferase
EAW52_RS18455	COG0429	hydrolase of the alpha beta-hydrolase fold
EAW52_RS18460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EAW52_RS18465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EAW52_RS18475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EAW52_RS18480	COG0730	response to heat
EAW52_RS18505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EAW52_RS18515	COG2234	aminopeptidase activity
EAW52_RS18520	COG3204	pilus organization
EAW52_RS18530	COG0179	Fumarylacetoacetate (FAA) hydrolase
EAW52_RS18535	COG0277	FAD linked oxidase domain protein
EAW52_RS18540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EAW52_RS18545	COG1683	Conserved Protein
EAW52_RS18570	COG1846	Transcriptional regulator
EAW52_RS18580	COG1566	PFAM secretion protein HlyD family protein
EAW52_RS18585	COG2814	Major facilitator Superfamily
EAW52_RS18605	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EAW52_RS18635	COG2982	Protein involved in outer membrane biogenesis
EAW52_RS18640	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS18670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EAW52_RS18675	COG0596	Alpha beta hydrolase
EAW52_RS18680	COG0251	oxidation-reduction process
EAW52_RS18690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EAW52_RS18695	COG1309	transcriptional regulator
EAW52_RS18710	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS18715	COG1482	cell wall glycoprotein biosynthetic process
EAW52_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS18725	COG0737	Belongs to the 5'-nucleotidase family
EAW52_RS18725	COG1525	nuclease
EAW52_RS18725	COG4085	toxin activity
EAW52_RS18740	COG0305	Participates in initiation and elongation during chromosome replication
EAW52_RS18760	COG0360	Binds together with S18 to 16S ribosomal RNA
EAW52_RS18765	COG4191	Histidine kinase
EAW52_RS18765	COG0784	Response regulator, receiver
EAW52_RS18775	COG0557	exoribonuclease II activity
EAW52_RS18795	COG0330	HflC and HflK could
EAW52_RS18800	COG0330	HflC and HflK could
EAW52_RS18805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EAW52_RS18815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EAW52_RS18825	COG0860	N-Acetylmuramoyl-L-alanine amidase
EAW52_RS18830	COG0802	atpase or kinase
EAW52_RS18835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EAW52_RS18835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EAW52_RS18860	COG1360	Flagellar Motor Protein
EAW52_RS18865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EAW52_RS18880	COG0688	phosphatidylethanolamine metabolic process
EAW52_RS18890	COG5001	Diguanylate cyclase
EAW52_RS18890	COG5002	protein histidine kinase activity
EAW52_RS18895	COG0560	Phosphoserine phosphatase
EAW52_RS18895	COG3830	Belongs to the UPF0237 family
EAW52_RS18910	COG0702	epimerase
EAW52_RS18915	COG0583	DNA-binding transcription factor activity
EAW52_RS18920	COG1760	l-serine dehydratase
EAW52_RS18925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EAW52_RS18930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EAW52_RS18945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EAW52_RS18950	COG0586	Pfam SNARE associated Golgi protein
EAW52_RS18955	COG3228	Belongs to the MtfA family
EAW52_RS18960	COG0668	transmembrane transport
EAW52_RS18970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EAW52_RS18975	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EAW52_RS18980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EAW52_RS18990	COG0142	geranyltranstransferase activity
EAW52_RS19000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EAW52_RS19005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EAW52_RS19010	COG3577	Aspartyl protease
EAW52_RS19015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EAW52_RS19020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EAW52_RS19030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EAW52_RS19045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EAW52_RS19045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EAW52_RS19065	COG3118	belongs to the thioredoxin family
EAW52_RS19080	COG1136	(ABC) transporter
EAW52_RS19095	COG3047	cAMP biosynthetic process
EAW52_RS19110	COG0733	neurotransmitter:sodium symporter activity
EAW52_RS19120	COG2186	Transcriptional regulator
EAW52_RS19125	COG1620	l-lactate permease
EAW52_RS19130	COG0247	lactate metabolic process
EAW52_RS19175	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EAW52_RS19180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EAW52_RS19185	COG1183	phosphatidylcholine synthase activity
EAW52_RS19190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EAW52_RS19195	COG0440	acetolactate synthase activity
EAW52_RS19200	COG0028	Belongs to the TPP enzyme family
EAW52_RS19220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EAW52_RS19240	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EAW52_RS19245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EAW52_RS19250	COG0295	cytidine deaminase activity
EAW52_RS19265	COG0436	Aminotransferase
EAW52_RS19270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EAW52_RS19275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EAW52_RS19285	COG5002	protein histidine kinase activity
EAW52_RS19310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EAW52_RS19320	COG0166	Belongs to the GPI family
EAW52_RS19335	COG0116	Belongs to the methyltransferase superfamily
EAW52_RS19335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EAW52_RS19370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EAW52_RS19375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EAW52_RS19380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EAW52_RS19390	COG0195	Participates in both transcription termination and antitermination
EAW52_RS19395	COG0779	Required for maturation of 30S ribosomal subunits
EAW52_RS19420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EAW52_RS19425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EAW52_RS19435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EAW52_RS19460	COG0505	Belongs to the CarA family
EAW52_RS19480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EAW52_RS19485	COG0497	DNA recombination
EAW52_RS19500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EAW52_RS19510	COG1289	transmembrane transporter activity
EAW52_RS19520	COG2814	Major facilitator Superfamily
EAW52_RS19550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EAW52_RS19565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EAW52_RS19575	COG0200	Binds to the 23S rRNA
EAW52_RS19580	COG1841	ribosomal large subunit assembly
EAW52_RS19600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EAW52_RS19605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EAW52_RS19630	COG0255	Belongs to the universal ribosomal protein uL29 family
EAW52_RS19640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EAW52_RS19645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EAW52_RS19655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EAW52_RS19660	COG0089	rRNA binding
EAW52_RS19675	COG0051	transcription antitermination factor activity, RNA binding
EAW52_RS19690	COG0049	tRNA binding
EAW52_RS19695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EAW52_RS19715	COG0222	ribosome binding
EAW52_RS19725	COG0081	regulation of translation
EAW52_RS19730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EAW52_RS19770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EAW52_RS19770	COG4651	solute:proton antiporter activity
EAW52_RS19775	COG2223	nitrite transmembrane transporter activity
EAW52_RS19805	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS19825	COG3300	MHYT domain
EAW52_RS19825	COG5001	Diguanylate cyclase
EAW52_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS19840	COG2610	gluconate transmembrane transporter activity
EAW52_RS19860	COG0657	acetylesterase activity
EAW52_RS19865	COG3958	Transketolase
EAW52_RS19870	COG3959	Transketolase, thiamine diphosphate binding domain
EAW52_RS19875	COG2271	Major facilitator Superfamily
EAW52_RS19880	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS19885	COG0583	DNA-binding transcription factor activity
EAW52_RS19920	COG0583	DNA-binding transcription factor activity
EAW52_RS19935	COG1741	Belongs to the pirin family
EAW52_RS19945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EAW52_RS19950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EAW52_RS19955	COG0745	RESPONSE REGULATOR receiver
EAW52_RS19960	COG2205	protein histidine kinase activity
EAW52_RS19970	COG2259	Doxx family
EAW52_RS19985	COG2814	Major facilitator Superfamily
EAW52_RS20000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EAW52_RS20010	COG1320	monovalent cation:proton antiporter activity
EAW52_RS20015	COG2212	antiporter activity
EAW52_RS20020	COG1863	multisubunit Na H antiporter MnhE subunit
EAW52_RS20025	COG0651	ATP synthesis coupled electron transport
EAW52_RS20030	COG1006	Multisubunit Na H antiporter MnhC subunit
EAW52_RS20035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EAW52_RS20035	COG2111	Na H antiporter
EAW52_RS20055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS20095	COG2814	Major facilitator Superfamily
EAW52_RS20135	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS20140	COG3384	dioxygenase
EAW52_RS20150	COG2271	Major facilitator Superfamily
EAW52_RS20155	COG3971	2-oxopent-4-enoate hydratase activity
EAW52_RS20165	COG1846	Transcriptional regulator
EAW52_RS20170	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS20195	COG0640	Transcriptional regulator
EAW52_RS20220	COG0656	L-ascorbic acid biosynthetic process
EAW52_RS20230	COG0531	amino acid
EAW52_RS20240	COG2197	response regulator
EAW52_RS20260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EAW52_RS20265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS20290	COG3209	COG3209 Rhs family protein
EAW52_RS20315	COG3209	COG3209 Rhs family protein
EAW52_RS20360	COG1741	Belongs to the pirin family
EAW52_RS20365	COG0583	DNA-binding transcription factor activity
EAW52_RS20370	COG0655	NAD(P)H dehydrogenase (quinone) activity
EAW52_RS20380	COG0583	DNA-binding transcription factor activity
EAW52_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS20400	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS20405	COG2207	Transcriptional regulator
EAW52_RS20415	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EAW52_RS20420	COG3052	prosthetic group binding
EAW52_RS20440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EAW52_RS20490	COG3274	enterobacterial common antigen metabolic process
EAW52_RS20495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EAW52_RS20495	COG2755	lipolytic protein G-D-S-L family
EAW52_RS20505	COG5002	protein histidine kinase activity
EAW52_RS20505	COG5001	Diguanylate cyclase
EAW52_RS20525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS20530	COG1120	ATPase activity
EAW52_RS20535	COG1968	undecaprenyl-diphosphatase activity
EAW52_RS20545	COG0417	DNA replication proofreading
EAW52_RS20550	COG1611	Belongs to the LOG family
EAW52_RS20560	COG1120	ATPase activity
EAW52_RS20565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS20570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS20595	COG0501	Belongs to the peptidase M48B family
EAW52_RS20600	COG1063	alcohol dehydrogenase
EAW52_RS20610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EAW52_RS20625	COG0028	Belongs to the TPP enzyme family
EAW52_RS20635	COG0586	Pfam SNARE associated Golgi protein
EAW52_RS20640	COG1073	alpha beta
EAW52_RS20645	COG2186	Transcriptional regulator
EAW52_RS20650	COG0823	Involved in the tonB-independent uptake of proteins
EAW52_RS20670	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS20675	COG0579	oxidoreductase
EAW52_RS20700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EAW52_RS20705	COG2271	Major facilitator Superfamily
EAW52_RS20710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EAW52_RS20715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EAW52_RS20720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EAW52_RS20725	COG1309	transcriptional regulator
EAW52_RS20730	COG1082	Xylose isomerase domain protein TIM barrel
EAW52_RS20730	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EAW52_RS20735	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS20740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EAW52_RS20750	COG4558	Periplasmic binding protein
EAW52_RS20755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS20765	COG0113	porphobilinogen synthase activity
EAW52_RS20780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EAW52_RS20785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EAW52_RS20805	COG1376	ErfK ybiS ycfS ynhG family protein
EAW52_RS20810	COG0768	penicillin binding
EAW52_RS20820	COG2814	Major facilitator Superfamily
EAW52_RS20825	COG0583	DNA-binding transcription factor activity
EAW52_RS20845	COG2814	Major facilitator Superfamily
EAW52_RS20880	COG0625	glutathione transferase activity
EAW52_RS20885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EAW52_RS20890	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EAW52_RS20935	COG1609	Transcriptional regulator
EAW52_RS20945	COG0673	inositol 2-dehydrogenase activity
EAW52_RS20950	COG5001	Diguanylate cyclase
EAW52_RS20965	COG2203	Gaf domain
EAW52_RS20965	COG4251	negative regulation of phosphorylation
EAW52_RS20965	COG5001	Diguanylate cyclase
EAW52_RS20965	COG3706	GGDEF domain
EAW52_RS21000	COG2323	membrane
EAW52_RS21030	COG2198	Histidine kinase
EAW52_RS21030	COG0643	Histidine kinase
EAW52_RS21045	COG0835	chemotaxis
EAW52_RS21055	COG0835	chemotaxis
EAW52_RS21060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EAW52_RS21065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EAW52_RS21070	COG2201	protein-glutamate methylesterase activity
EAW52_RS21085	COG0583	DNA-binding transcription factor activity
EAW52_RS21095	COG1475	DNA binding
EAW52_RS21110	COG0776	regulation of translation
EAW52_RS21120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EAW52_RS21125	COG1609	Transcriptional regulator
EAW52_RS21135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAW52_RS21140	COG0523	cobalamin synthesis protein
EAW52_RS21170	COG4251	negative regulation of phosphorylation
EAW52_RS21170	COG5001	Diguanylate cyclase
EAW52_RS21170	COG2203	Gaf domain
EAW52_RS21170	COG3706	GGDEF domain
EAW52_RS21200	COG1914	H( )-stimulated, divalent metal cation uptake system
EAW52_RS21205	COG1321	iron dependent repressor
EAW52_RS21220	COG0738	Major facilitator superfamily
EAW52_RS21225	COG3226	Transcriptional regulator
EAW52_RS21240	COG1971	Probably functions as a manganese efflux pump
EAW52_RS21250	COG0028	Belongs to the TPP enzyme family
EAW52_RS21255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS21265	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS21295	COG3766	membrane
EAW52_RS21305	COG0754	glutathionylspermidine amidase activity
EAW52_RS21320	COG3284	Transcriptional regulator
EAW52_RS21340	COG0789	Transcriptional regulator
EAW52_RS21385	COG2351	hydroxyisourate hydrolase activity
EAW52_RS21390	COG0583	DNA-binding transcription factor activity
EAW52_RS21400	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS21420	COG0697	spore germination
EAW52_RS21430	COG4953	penicillin-binding protein 1C
EAW52_RS21435	COG2373	Large extracellular alpha-helical protein
EAW52_RS21440	COG3415	Transposase
EAW52_RS21440	COG2801	Transposase and inactivated derivatives
EAW52_RS21445	COG0346	lactoylglutathione lyase activity
EAW52_RS21450	COG1349	DNA-binding transcription factor activity
EAW52_RS21490	COG3729	General stress protein
EAW52_RS21505	COG1309	transcriptional regulator
EAW52_RS21510	COG0604	alcohol dehydrogenase
EAW52_RS21520	COG0583	DNA-binding transcription factor activity
EAW52_RS21540	COG0697	spore germination
EAW52_RS21550	COG2271	Major facilitator Superfamily
EAW52_RS21560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EAW52_RS21570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EAW52_RS21585	COG0025	NhaP-type Na H and K H
EAW52_RS21590	COG4251	negative regulation of phosphorylation
EAW52_RS21595	COG5001	Diguanylate cyclase
EAW52_RS21595	COG3300	MHYT domain
EAW52_RS21605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EAW52_RS21645	COG0024	Methionine aminopeptidase
EAW52_RS21655	COG0730	response to heat
EAW52_RS21670	COG2031	fatty acid transporter
EAW52_RS21725	COG4181	ATPase activity
EAW52_RS21730	COG3274	enterobacterial common antigen metabolic process
EAW52_RS21790	COG3940	Belongs to the glycosyl hydrolase 43 family
EAW52_RS21825	COG4585	Histidine kinase
EAW52_RS21830	COG2197	response regulator
EAW52_RS21840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EAW52_RS21845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EAW52_RS21860	COG3547	Transposase (IS116 IS110 IS902 family)
EAW52_RS21870	COG0583	DNA-binding transcription factor activity
EAW52_RS21895	COG0587	DNA-directed DNA polymerase activity
EAW52_RS21905	COG0489	protein tyrosine kinase activity
EAW52_RS21940	COG0583	DNA-binding transcription factor activity
EAW52_RS21945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EAW52_RS21960	COG1472	Belongs to the glycosyl hydrolase 3 family
EAW52_RS21970	COG2205	protein histidine kinase activity
EAW52_RS21990	COG1280	lysine exporter protein (LysE YggA)
EAW52_RS22000	COG3474	cytochrome
EAW52_RS22015	COG3437	response regulator, receiver
EAW52_RS22020	COG1100	Small GTP-binding protein
EAW52_RS22025	COG3852	Histidine kinase
EAW52_RS22030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EAW52_RS22035	COG4251	negative regulation of phosphorylation
EAW52_RS22040	COG0784	Response regulator, receiver
EAW52_RS22050	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS22055	COG3387	PFAM Glycoside hydrolase 15-related
EAW52_RS22060	COG0277	FAD linked oxidase domain protein
EAW52_RS22075	COG0436	Aminotransferase
EAW52_RS22080	COG1846	Transcriptional regulator
EAW52_RS22085	COG2807	transmembrane transport
EAW52_RS22095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EAW52_RS22100	COG0583	DNA-binding transcription factor activity
EAW52_RS22110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EAW52_RS22125	COG1620	l-lactate permease
EAW52_RS22130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EAW52_RS22135	COG2367	Beta-lactamase
EAW52_RS22150	COG1253	flavin adenine dinucleotide binding
EAW52_RS22160	COG0210	DNA helicase
EAW52_RS22185	COG1733	regulation of RNA biosynthetic process
EAW52_RS22190	COG2910	NAD(P)H-binding
EAW52_RS22220	COG0659	secondary active sulfate transmembrane transporter activity
EAW52_RS22230	COG1944	ATP diphosphatase activity
EAW52_RS22240	COG3152	Membrane
EAW52_RS22260	COG0730	response to heat
EAW52_RS22265	COG0583	DNA-binding transcription factor activity
EAW52_RS22290	COG3781	membrane
EAW52_RS22310	COG0840	transmembrane signaling receptor activity
EAW52_RS22315	COG0443	Heat shock 70 kDa protein
EAW52_RS22320	COG0484	heat shock protein binding
EAW52_RS22325	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS22330	COG0640	Transcriptional regulator
EAW52_RS22360	COG2808	Putative FMN-binding domain
EAW52_RS22365	COG0625	glutathione transferase activity
EAW52_RS22375	COG2204	response regulator
EAW52_RS22415	COG3781	membrane
EAW52_RS22420	COG0583	DNA-binding transcription factor activity
EAW52_RS22430	COG3384	dioxygenase
EAW52_RS22450	COG2201	protein-glutamate methylesterase activity
EAW52_RS22455	COG1234	tRNA 3'-trailer cleavage
EAW52_RS22475	COG1696	Membrane protein involved in D-alanine export
EAW52_RS22490	COG3622	Belongs to the hyi family
EAW52_RS22510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EAW52_RS22515	COG2010	Cytochrome c
EAW52_RS22515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EAW52_RS22535	COG1280	lysine exporter protein (LysE YggA)
EAW52_RS22570	COG0306	phosphate transporter
EAW52_RS22580	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS22590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS22650	COG0419	ATPase involved in DNA repair
EAW52_RS22680	COG2203	Gaf domain
EAW52_RS22680	COG3706	GGDEF domain
EAW52_RS22680	COG5001	Diguanylate cyclase
EAW52_RS22680	COG4251	negative regulation of phosphorylation
EAW52_RS22705	COG0251	oxidation-reduction process
EAW52_RS22735	COG0484	heat shock protein binding
EAW52_RS22775	COG5599	Phosphatase
EAW52_RS22835	COG4794	Type iii secretion
EAW52_RS22845	COG4792	protein secretion
EAW52_RS22895	COG4669	(LipO)protein
EAW52_RS22930	COG1388	LysM domain
EAW52_RS22930	COG0741	lytic transglycosylase activity
EAW52_RS22940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EAW52_RS22960	COG0583	DNA-binding transcription factor activity
EAW52_RS22985	COG2080	2 iron, 2 sulfur cluster binding
EAW52_RS22990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EAW52_RS22995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EAW52_RS23015	COG2267	carboxylic ester hydrolase activity
EAW52_RS23020	COG0671	phosphoesterase, PA-phosphatase related
EAW52_RS23020	COG2453	phosphatase
EAW52_RS23030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EAW52_RS23040	COG4589	Belongs to the CDS family
EAW52_RS23045	COG1192	Involved in chromosome partitioning
EAW52_RS23050	COG1475	DNA binding
EAW52_RS23075	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EAW52_RS23080	COG1960	acyl-CoA dehydrogenase activity
EAW52_RS23085	COG2079	MmgE PrpD family protein
EAW52_RS23095	COG2301	Belongs to the HpcH HpaI aldolase family
EAW52_RS23105	COG1538	Outer membrane efflux protein
EAW52_RS23115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EAW52_RS23145	COG0583	DNA-binding transcription factor activity
EAW52_RS23150	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS23165	COG1335	isochorismatase
EAW52_RS23170	COG2309	aminopeptidase activity
EAW52_RS23175	COG0596	Alpha beta hydrolase
EAW52_RS23180	COG3473	Maleate cis-trans isomerase
EAW52_RS23185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EAW52_RS23195	COG0411	ABC transporter
EAW52_RS23205	COG0559	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS23220	COG3395	kinase activity
EAW52_RS23225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EAW52_RS23240	COG2985	domain, Protein
EAW52_RS23260	COG3706	GGDEF domain
EAW52_RS23275	COG0583	DNA-binding transcription factor activity
EAW52_RS23300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EAW52_RS23305	COG0154	amidase activity
EAW52_RS23310	COG0444	Belongs to the ABC transporter superfamily
EAW52_RS23315	COG4608	Belongs to the ABC transporter superfamily
EAW52_RS23320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAW52_RS23330	COG0747	negative chemotaxis
EAW52_RS23340	COG2186	Transcriptional regulator
EAW52_RS23360	COG0583	DNA-binding transcription factor activity
EAW52_RS23370	COG0154	amidase activity
EAW52_RS23375	COG4221	oxidoreductase activity
EAW52_RS23380	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS23395	COG1309	transcriptional regulator
EAW52_RS23415	COG2814	Major facilitator Superfamily
EAW52_RS23420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EAW52_RS23425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EAW52_RS23460	COG0154	amidase activity
EAW52_RS23465	COG0583	DNA-binding transcription factor activity
EAW52_RS23475	COG3842	ATPase activity
EAW52_RS23485	COG1177	transmembrane transport
EAW52_RS23505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS23505	COG2022	thiamine diphosphate biosynthetic process
EAW52_RS23510	COG0251	oxidation-reduction process
EAW52_RS23515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS23550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EAW52_RS23560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EAW52_RS23565	COG0583	DNA-binding transcription factor activity
EAW52_RS23585	COG1802	Transcriptional regulator
EAW52_RS23590	COG2721	sulfolactate sulfo-lyase activity
EAW52_RS23595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EAW52_RS23600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EAW52_RS23605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EAW52_RS23615	COG0179	Fumarylacetoacetate (FAA) hydrolase
EAW52_RS23620	COG1304	FMN binding
EAW52_RS23645	COG0583	DNA-binding transcription factor activity
EAW52_RS23680	COG0583	DNA-binding transcription factor activity
EAW52_RS23690	COG0667	Aldo Keto reductase
EAW52_RS23750	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EAW52_RS23755	COG4266	Belongs to the allantoicase family
EAW52_RS23810	COG1079	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS23815	COG4603	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS23820	COG3845	ABC transporter
EAW52_RS23825	COG1309	transcriptional regulator
EAW52_RS23860	COG0702	epimerase
EAW52_RS23870	COG0300	oxidoreductase activity
EAW52_RS23920	COG3733	amine oxidase
EAW52_RS23935	COG0583	DNA-binding transcription factor activity
EAW52_RS23945	COG0840	transmembrane signaling receptor activity
EAW52_RS23985	COG1012	belongs to the aldehyde dehydrogenase family
EAW52_RS23995	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EAW52_RS24005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS24015	COG0601	transmembrane transport
EAW52_RS24020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAW52_RS24040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EAW52_RS24050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EAW52_RS24065	COG1522	sequence-specific DNA binding
EAW52_RS24075	COG2271	Major facilitator Superfamily
EAW52_RS24085	COG0154	amidase activity
EAW52_RS24110	COG2356	endonuclease I
EAW52_RS24115	COG3755	Protein conserved in bacteria
EAW52_RS24120	COG0556	nucleotide-excision repair
EAW52_RS24255	COG5654	RES domain protein
EAW52_RS24280	COG1172	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS24285	COG1079	Belongs to the binding-protein-dependent transport system permease family
EAW52_RS24290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EAW52_RS24295	COG1335	isochorismatase
EAW52_RS24300	COG3845	ABC transporter
EAW52_RS24315	COG1802	Transcriptional regulator
EAW52_RS24355	COG0784	Response regulator, receiver
EAW52_RS24355	COG4191	Histidine kinase
EAW52_RS24430	COG2207	Transcriptional regulator
EAW52_RS24465	COG0583	DNA-binding transcription factor activity
EAW52_RS24470	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS24495	COG1247	-acetyltransferase
EAW52_RS24500	COG1309	transcriptional regulator
EAW52_RS24515	COG1902	pentaerythritol trinitrate reductase activity
EAW52_RS24520	COG2207	Transcriptional regulator
EAW52_RS24540	COG1309	transcriptional regulator
EAW52_RS24545	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS24645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EAW52_RS24665	COG2356	endonuclease I
EAW52_RS24675	COG0616	signal peptide processing
EAW52_RS24680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EAW52_RS24875	COG0714	Associated with various cellular activities
EAW52_RS24980	COG0582	viral genome integration into host DNA
EAW52_RS25005	COG3547	Transposase (IS116 IS110 IS902 family)
EAW52_RS25055	COG3547	Transposase (IS116 IS110 IS902 family)
EAW52_RS25095	COG3300	MHYT domain
EAW52_RS25095	COG5001	Diguanylate cyclase
EAW52_RS25100	COG4191	Histidine kinase
EAW52_RS25100	COG0784	Response regulator, receiver
EAW52_RS25150	COG2072	flavoprotein involved in K transport
EAW52_RS25185	COG0583	DNA-binding transcription factor activity
EAW52_RS25225	COG0395	ABC-type sugar transport system, permease component
EAW52_RS25230	COG1175	transmembrane transport
EAW52_RS25250	COG1570	exodeoxyribonuclease VII activity
EAW52_RS25315	COG1028	Short-chain dehydrogenase reductase Sdr
EAW52_RS25320	COG2814	Major facilitator Superfamily
EAW52_RS25325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EAW52_RS25330	COG0179	Fumarylacetoacetate (FAA) hydrolase
EAW52_RS25345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EAW52_RS25355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EAW52_RS25365	COG1733	regulation of RNA biosynthetic process
EAW52_RS25370	COG1233	COG1233 Phytoene dehydrogenase and related
EAW52_RS25415	COG2814	Major facilitator Superfamily
EAW52_RS25440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EAW52_RS25450	COG2271	Major facilitator Superfamily
EAW52_RS25455	COG0473	3-isopropylmalate dehydrogenase activity
EAW52_RS25455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EAW52_RS25475	COG4774	siderophore transport
EAW52_RS25515	COG0583	DNA-binding transcription factor activity
EAW52_RS25520	COG2175	clavaminate synthase activity
EAW52_RS25540	COG0747	negative chemotaxis
EAW52_RS25560	COG4608	Belongs to the ABC transporter superfamily
EAW52_RS25580	COG1522	sequence-specific DNA binding
EAW52_RS25585	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EAW52_RS25640	COG0667	Aldo Keto reductase
EAW52_RS25645	COG0583	DNA-binding transcription factor activity
EAW52_RS25650	COG2801	Transposase and inactivated derivatives
EAW52_RS25650	COG3415	Transposase
EAW52_RS25675	COG1301	dicarboxylic acid transport
EAW52_RS25680	COG4948	Mandelate Racemase Muconate Lactonizing
EAW52_RS25685	COG0583	DNA-binding transcription factor activity
EAW52_RS25705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAW52_RS25710	COG2814	Major facilitator Superfamily
EAW52_RS25745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAW52_RS25750	COG2222	sugar isomerase