locus-tag	class	description
G3M63_RS00010	COG1067	ATP-dependent peptidase activity
G3M63_RS00015	COG1587	Uroporphyrinogen-III synthase
G3M63_RS00045	COG0840	transmembrane signaling receptor activity
G3M63_RS00050	COG1063	alcohol dehydrogenase
G3M63_RS00070	COG4969	Belongs to the N-Me-Phe pilin family
G3M63_RS00090	COG0237	dephospho-CoA kinase activity
G3M63_RS00100	COG0494	nUDIX hydrolase
G3M63_RS00105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3M63_RS00110	COG1047	Peptidyl-prolyl cis-trans
G3M63_RS00115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G3M63_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G3M63_RS00125	COG0196	riboflavin kinase activity
G3M63_RS00135	COG0268	Binds directly to 16S ribosomal RNA
G3M63_RS00140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G3M63_RS00150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G3M63_RS00160	COG0142	geranyltranstransferase activity
G3M63_RS00165	COG0545	Peptidyl-prolyl cis-trans isomerase
G3M63_RS00170	COG2252	PERMEase
G3M63_RS00175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3M63_RS00200	COG1970	mechanosensitive ion channel activity
G3M63_RS00290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G3M63_RS00300	COG0739	heme binding
G3M63_RS00330	COG1181	Belongs to the D-alanine--D-alanine ligase family
G3M63_RS00340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3M63_RS00345	COG0772	Belongs to the SEDS family
G3M63_RS00350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G3M63_RS00355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3M63_RS00360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3M63_RS00400	COG3107	peptidoglycan biosynthetic process
G3M63_RS00405	COG0792	nuclease activity
G3M63_RS00415	COG2823	Periplasmic or secreted lipoprotein
G3M63_RS00420	COG2969	positive regulation of protein catabolic process
G3M63_RS00425	COG0625	glutathione transferase activity
G3M63_RS00430	COG2857	Cytochrome c1
G3M63_RS00435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3M63_RS00440	COG0723	plastoquinol--plastocyanin reductase activity
G3M63_RS00445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G3M63_RS00450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G3M63_RS00455	COG0667	Aldo Keto reductase
G3M63_RS00460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3M63_RS00470	COG3105	Protein conserved in bacteria
G3M63_RS00475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3M63_RS00480	COG1127	ABC transporter
G3M63_RS00495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3M63_RS00495	COG0519	Catalyzes the synthesis of GMP from XMP
G3M63_RS00505	COG1570	exodeoxyribonuclease VII activity
G3M63_RS00510	COG0739	heme binding
G3M63_RS00515	COG0668	transmembrane transport
G3M63_RS00520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3M63_RS00525	COG1160	GTP binding
G3M63_RS00535	COG2976	Protein conserved in bacteria
G3M63_RS00540	COG0124	histidyl-tRNA synthetase
G3M63_RS00545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G3M63_RS00565	COG0105	UTP biosynthetic process
G3M63_RS00570	COG1104	cysteine desulfurase activity
G3M63_RS00575	COG1045	serine acetyltransferase
G3M63_RS00600	COG1862	Preprotein translocase
G3M63_RS00605	COG0343	queuine tRNA-ribosyltransferase activity
G3M63_RS00610	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G3M63_RS00620	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS00625	COG0492	ferredoxin-NADP+ reductase activity
G3M63_RS00630	COG0450	alkyl hydroperoxide reductase
G3M63_RS00635	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
G3M63_RS00655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G3M63_RS00665	COG0204	Acyl-transferase
G3M63_RS00670	COG2885	chlorophyll binding
G3M63_RS00675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3M63_RS00680	COG2852	Protein conserved in bacteria
G3M63_RS00685	COG1301	dicarboxylic acid transport
G3M63_RS00700	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS00705	COG0183	Belongs to the thiolase family
G3M63_RS00720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3M63_RS00755	COG4807	Protein conserved in bacteria
G3M63_RS00775	COG3609	addiction module antidote protein, CC2985 family
G3M63_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS00805	COG5001	Diguanylate cyclase
G3M63_RS00805	COG5002	protein histidine kinase activity
G3M63_RS00810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G3M63_RS00820	COG0084	hydrolase, TatD family'
G3M63_RS00830	COG0300	oxidoreductase activity
G3M63_RS00835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G3M63_RS00845	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G3M63_RS00850	COG4191	Histidine kinase
G3M63_RS00875	COG1252	NADH dehydrogenase
G3M63_RS00900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G3M63_RS00910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G3M63_RS00915	COG0189	ligase activity
G3M63_RS00915	COG4067	protein conserved in archaea
G3M63_RS00935	COG1011	Hydrolase
G3M63_RS00940	COG0494	nUDIX hydrolase
G3M63_RS00950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3M63_RS00955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3M63_RS00955	COG2111	Na H antiporter
G3M63_RS00960	COG1006	Multisubunit Na H antiporter MnhC subunit
G3M63_RS00965	COG0651	ATP synthesis coupled electron transport
G3M63_RS00970	COG1863	multisubunit Na H antiporter MnhE subunit
G3M63_RS00975	COG2212	antiporter activity
G3M63_RS00980	COG1320	monovalent cation:proton antiporter activity
G3M63_RS00985	COG0697	spore germination
G3M63_RS00990	COG0628	permease
G3M63_RS01010	COG3268	Saccharopine dehydrogenase
G3M63_RS01015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G3M63_RS01020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3M63_RS01025	COG3025	triphosphatase activity
G3M63_RS01030	COG1392	Phosphate transport regulator
G3M63_RS01035	COG0306	phosphate transporter
G3M63_RS01050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G3M63_RS01055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3M63_RS01055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G3M63_RS01060	COG0129	dihydroxy-acid dehydratase activity
G3M63_RS01070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G3M63_RS01075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G3M63_RS01080	COG0730	response to heat
G3M63_RS01090	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
G3M63_RS01095	COG0494	nUDIX hydrolase
G3M63_RS01110	COG3830	Belongs to the UPF0237 family
G3M63_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS01130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3M63_RS01135	COG0431	NADPH-dependent FMN reductase
G3M63_RS01140	COG2239	Acts as a magnesium transporter
G3M63_RS01145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3M63_RS01145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3M63_RS01150	COG0509	glycine decarboxylation via glycine cleavage system
G3M63_RS01160	COG1178	ABC-type Fe3 transport system permease component
G3M63_RS01170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3M63_RS01175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3M63_RS01180	COG0006	proline dipeptidase activity
G3M63_RS01205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G3M63_RS01215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3M63_RS01220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G3M63_RS01230	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3M63_RS01235	COG0277	FAD linked oxidase domain protein
G3M63_RS01240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3M63_RS01245	COG1683	Conserved Protein
G3M63_RS01275	COG0745	RESPONSE REGULATOR receiver
G3M63_RS01280	COG3212	peptidase
G3M63_RS01300	COG4771	TonB-dependent receptor
G3M63_RS01305	COG0625	glutathione transferase activity
G3M63_RS01320	COG2076	Multidrug Resistance protein
G3M63_RS01355	COG2962	Rard protein
G3M63_RS01370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3M63_RS01375	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G3M63_RS01395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G3M63_RS01410	COG0517	IMP dehydrogenase activity
G3M63_RS01425	COG1462	curli production assembly transport component CsgG
G3M63_RS01460	COG0483	inositol monophosphate 1-phosphatase activity
G3M63_RS01490	COG0330	HflC and HflK could
G3M63_RS01495	COG1030	water channel activity
G3M63_RS01525	COG0058	SHG alpha-glucan phosphorylase activity
G3M63_RS01530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3M63_RS01535	COG1597	lipid kinase activity
G3M63_RS01540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G3M63_RS01550	COG4628	conserved protein (DUF2132)
G3M63_RS01555	COG0724	RNA recognition motif
G3M63_RS01565	COG2081	HI0933 family
G3M63_RS01580	COG3706	GGDEF domain
G3M63_RS01585	COG0513	Belongs to the DEAD box helicase family
G3M63_RS01590	COG3273	potassium ion transport
G3M63_RS01590	COG0471	metal ion transport
G3M63_RS01605	COG2133	pyrroloquinoline quinone binding
G3M63_RS01620	COG0191	fructose-bisphosphate aldolase activity
G3M63_RS01625	COG0126	phosphoglycerate kinase activity
G3M63_RS01630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3M63_RS01635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G3M63_RS01640	COG2226	methyltransferase
G3M63_RS01645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G3M63_RS01655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G3M63_RS01660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G3M63_RS01665	COG0513	Belongs to the DEAD box helicase family
G3M63_RS01680	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS01685	COG0583	DNA-binding transcription factor activity
G3M63_RS01695	COG2130	NADP-dependent
G3M63_RS01720	COG4604	ABC transporter, ATP-binding protein
G3M63_RS01725	COG4605	iron ion homeostasis
G3M63_RS01730	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3M63_RS01735	COG4607	ABC-type enterochelin transport system periplasmic component
G3M63_RS01740	COG2353	YceI-like domain
G3M63_RS01745	COG3038	cytochrome b561
G3M63_RS01750	COG0134	indole-3-glycerol-phosphate synthase activity
G3M63_RS01755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3M63_RS01760	COG0512	Glutamine amidotransferase of anthranilate synthase
G3M63_RS01770	COG0546	phosphoglycolate phosphatase activity
G3M63_RS01775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G3M63_RS01780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G3M63_RS01785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3M63_RS01795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G3M63_RS01805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3M63_RS01815	COG2967	ApaG domain
G3M63_RS01820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G3M63_RS01825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G3M63_RS01830	COG2766	serine protein kinase
G3M63_RS01835	COG2718	Belongs to the UPF0229 family
G3M63_RS01840	COG2719	SpoVR family
G3M63_RS01845	COG0617	tRNA 3'-terminal CCA addition
G3M63_RS01855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G3M63_RS01865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G3M63_RS01870	COG1307	EDD domain protein, DegV family
G3M63_RS01880	COG0358	DNA primase activity
G3M63_RS01915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G3M63_RS01920	COG0829	nickel cation binding
G3M63_RS01925	COG0831	urea catabolic process
G3M63_RS01930	COG0832	Belongs to the urease beta subunit family
G3M63_RS01935	COG0804	urea catabolic process
G3M63_RS01940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G3M63_RS01945	COG0830	nickel cation binding
G3M63_RS01950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G3M63_RS01960	COG3938	Belongs to the proline racemase family
G3M63_RS01965	COG3321	synthase
G3M63_RS01965	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS01965	COG0604	alcohol dehydrogenase
G3M63_RS01980	COG4181	ATPase activity
G3M63_RS01985	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS01990	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS01995	COG0471	metal ion transport
G3M63_RS01995	COG3273	potassium ion transport
G3M63_RS02000	COG2873	o-acetylhomoserine
G3M63_RS02005	COG1192	Involved in chromosome partitioning
G3M63_RS02010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G3M63_RS02015	COG0493	'glutamate synthase
G3M63_RS02020	COG0067	glutamate synthase
G3M63_RS02020	COG0070	glutamate synthase
G3M63_RS02020	COG0069	glutamate synthase activity
G3M63_RS02030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G3M63_RS02035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3M63_RS02075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G3M63_RS02080	COG4988	ABC transporter
G3M63_RS02085	COG1294	oxidase, subunit
G3M63_RS02090	COG1271	oxidase subunit
G3M63_RS02095	COG1346	cytolysis
G3M63_RS02110	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS02115	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS02135	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
G3M63_RS02180	COG0668	transmembrane transport
G3M63_RS02235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G3M63_RS02240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3M63_RS02245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3M63_RS02250	COG1120	ATPase activity
G3M63_RS02255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G3M63_RS02260	COG0406	alpha-ribazole phosphatase activity
G3M63_RS02265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G3M63_RS02275	COG1492	cobalamin metabolic process
G3M63_RS02290	COG0778	Nitroreductase
G3M63_RS02295	COG1797	cobyrinic acid a,c-diamide synthase activity
G3M63_RS02310	COG4206	TonB-dependent receptor
G3M63_RS02320	COG3257	ureidoglycine aminohydrolase activity
G3M63_RS02350	COG1253	flavin adenine dinucleotide binding
G3M63_RS02370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3M63_RS02380	COG5002	protein histidine kinase activity
G3M63_RS02385	COG1715	Restriction endonuclease
G3M63_RS02410	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
G3M63_RS02430	COG1462	curli production assembly transport component CsgG
G3M63_RS02480	COG2814	Major facilitator Superfamily
G3M63_RS02505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3M63_RS02525	COG0640	Transcriptional regulator
G3M63_RS02565	COG2132	Multicopper oxidase
G3M63_RS02570	COG2132	Multicopper oxidase
G3M63_RS02590	COG3387	PFAM Glycoside hydrolase 15-related
G3M63_RS02600	COG3039	Transposase
G3M63_RS02640	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3M63_RS02670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3M63_RS02760	COG5654	RES domain protein
G3M63_RS02765	COG5642	Protein of unknown function (DUF2384)
G3M63_RS02840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G3M63_RS02855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G3M63_RS02910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3M63_RS02920	COG0697	spore germination
G3M63_RS02930	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G3M63_RS02935	COG1194	a g-specific adenine glycosylase
G3M63_RS02945	COG0579	oxidoreductase
G3M63_RS02950	COG0131	Imidazoleglycerol-phosphate dehydratase
G3M63_RS02955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G3M63_RS02965	COG0107	imidazoleglycerol-phosphate synthase activity
G3M63_RS02970	COG2861	carbohydrate metabolic process
G3M63_RS02975	COG0793	Belongs to the peptidase S41A family
G3M63_RS02980	COG4942	peptidase
G3M63_RS02990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G3M63_RS03000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G3M63_RS03005	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3M63_RS03025	COG0488	(ABC) transporter
G3M63_RS03030	COG1671	Belongs to the UPF0178 family
G3M63_RS03040	COG3706	GGDEF domain
G3M63_RS03055	COG0248	Ppx GppA phosphatase
G3M63_RS03070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G3M63_RS03085	COG3071	HemY protein
G3M63_RS03110	COG2972	Histidine kinase
G3M63_RS03110	COG0745	RESPONSE REGULATOR receiver
G3M63_RS03115	COG0165	Argininosuccinate lyase
G3M63_RS03130	COG2957	Belongs to the agmatine deiminase family
G3M63_RS03165	COG2272	Belongs to the type-B carboxylesterase lipase family
G3M63_RS03175	COG0174	glutamine synthetase
G3M63_RS03180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G3M63_RS03185	COG0174	glutamine synthetase
G3M63_RS03200	COG3842	ATPase activity
G3M63_RS03205	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3M63_RS03210	COG1177	transmembrane transport
G3M63_RS03220	COG1309	transcriptional regulator
G3M63_RS03240	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS03255	COG0330	HflC and HflK could
G3M63_RS03290	COG1846	Transcriptional regulator
G3M63_RS03295	COG0367	asparagine synthase
G3M63_RS03300	COG2918	glutathione biosynthetic process
G3M63_RS03300	COG0189	ligase activity
G3M63_RS03305	COG1363	Peptidase, m42
G3M63_RS03310	COG4772	TonB-dependent receptor
G3M63_RS03335	COG1454	alcohol dehydrogenase
G3M63_RS03350	COG1024	Enoyl-CoA hydratase
G3M63_RS03355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G3M63_RS03370	COG2363	Small membrane protein
G3M63_RS03375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3M63_RS03405	COG2177	Part of the ABC transporter FtsEX involved in
G3M63_RS03410	COG2884	Cell division ATP-binding protein ftsE
G3M63_RS03415	COG0552	protein localization to endoplasmic reticulum
G3M63_RS03420	COG0612	Peptidase, M16
G3M63_RS03425	COG0612	Peptidase, M16
G3M63_RS03430	COG0742	ribosomal rna small subunit methyltransferase
G3M63_RS03445	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G3M63_RS03450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G3M63_RS03455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G3M63_RS03475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G3M63_RS03490	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS03495	COG0183	Belongs to the thiolase family
G3M63_RS03515	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS03525	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS03525	COG1024	Enoyl-CoA hydratase
G3M63_RS03530	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS03550	COG3180	Ammonia monooxygenase
G3M63_RS03560	COG1968	undecaprenyl-diphosphatase activity
G3M63_RS03595	COG0189	ligase activity
G3M63_RS03595	COG4067	protein conserved in archaea
G3M63_RS03600	COG2020	methyltransferase activity
G3M63_RS03615	COG0004	ammonium transporteR
G3M63_RS03630	COG0739	heme binding
G3M63_RS03635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G3M63_RS03640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G3M63_RS03645	COG2003	Belongs to the UPF0758 family
G3M63_RS03650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G3M63_RS03655	COG0756	dUTP diphosphatase activity
G3M63_RS03665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3M63_RS03695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G3M63_RS03700	COG1561	YicC-like family, N-terminal region
G3M63_RS03710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3M63_RS03730	COG3384	dioxygenase
G3M63_RS03735	COG0583	DNA-binding transcription factor activity
G3M63_RS03740	COG0194	GDP metabolic process
G3M63_RS03745	COG1758	RNA polymerase activity
G3M63_RS03750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3M63_RS03760	COG1764	response to oxidative stress
G3M63_RS03775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G3M63_RS03800	COG3161	chorismate lyase activity
G3M63_RS03835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G3M63_RS03840	COG0573	inorganic phosphate transmembrane transporter activity
G3M63_RS03845	COG0581	inorganic phosphate transmembrane transporter activity
G3M63_RS03855	COG0704	Plays a role in the regulation of phosphate uptake
G3M63_RS03860	COG1607	acyl-coa hydrolase
G3M63_RS03865	COG0210	DNA helicase
G3M63_RS03875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3M63_RS03880	COG1737	Transcriptional regulator
G3M63_RS03890	COG3791	Glutathione-dependent formaldehyde-activating
G3M63_RS03895	COG2996	Protein conserved in bacteria
G3M63_RS03915	COG0784	Response regulator, receiver
G3M63_RS03925	COG1940	carbohydrate kinase activity
G3M63_RS03930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G3M63_RS03945	COG0530	calcium, potassium:sodium antiporter activity
G3M63_RS03955	COG2217	Heavy metal translocating P-type atpase
G3M63_RS03960	COG0693	protein deglycase activity
G3M63_RS03970	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G3M63_RS03990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G3M63_RS03990	COG3008	intermembrane lipid transfer
G3M63_RS03995	COG2995	paraquat-inducible protein a
G3M63_RS04000	COG2995	paraquat-inducible protein a
G3M63_RS04005	COG3038	cytochrome b561
G3M63_RS04015	COG0386	Belongs to the glutathione peroxidase family
G3M63_RS04030	COG2146	nitrite reductase [NAD(P)H] activity
G3M63_RS04030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3M63_RS04035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3M63_RS04035	COG2146	nitrite reductase [NAD(P)H] activity
G3M63_RS04040	COG2116	formate transmembrane transporter activity
G3M63_RS04045	COG0515	serine threonine protein kinase
G3M63_RS04045	COG2815	serine threonine protein kinase
G3M63_RS04065	COG1073	alpha beta
G3M63_RS04120	COG0488	(ABC) transporter
G3M63_RS04140	COG1929	Belongs to the glycerate kinase type-1 family
G3M63_RS04145	COG2610	gluconate transmembrane transporter activity
G3M63_RS04155	COG0439	Biotin carboxylase
G3M63_RS04160	COG5016	pyruvate
G3M63_RS04160	COG0511	ligase activity, forming carbon-carbon bonds
G3M63_RS04180	COG2130	NADP-dependent
G3M63_RS04185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G3M63_RS04190	COG0339	signal peptide processing
G3M63_RS04195	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G3M63_RS04205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3M63_RS04210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3M63_RS04215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G3M63_RS04240	COG1612	heme a metabolic process
G3M63_RS04245	COG0109	protoheme IX farnesyltransferase activity
G3M63_RS04260	COG2161	toxin-antitoxin pair type II binding
G3M63_RS04265	COG4115	mRNA cleavage
G3M63_RS04340	COG1201	RNA secondary structure unwinding
G3M63_RS04345	COG1793	dna ligase
G3M63_RS04350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3M63_RS04350	COG1793	dna ligase
G3M63_RS04355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G3M63_RS04360	COG1121	(ABC) transporter
G3M63_RS04365	COG0735	belongs to the Fur family
G3M63_RS04370	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
G3M63_RS04390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G3M63_RS04410	COG3023	N-Acetylmuramoyl-L-alanine amidase
G3M63_RS04415	COG0700	Nucleoside recognition
G3M63_RS04425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3M63_RS04435	COG1396	sequence-specific DNA binding
G3M63_RS04435	COG1917	Cupin 2, conserved barrel domain protein
G3M63_RS04455	COG0492	ferredoxin-NADP+ reductase activity
G3M63_RS04465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G3M63_RS04490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G3M63_RS04495	COG1984	allophanate hydrolase subunit 2
G3M63_RS04510	COG0579	oxidoreductase
G3M63_RS04525	COG1620	l-lactate permease
G3M63_RS04535	COG5520	Belongs to the glycosyl hydrolase 30 family
G3M63_RS04535	COG4447	cellulose binding
G3M63_RS04535	COG3291	Pkd domain containing protein
G3M63_RS04540	COG0489	protein tyrosine kinase activity
G3M63_RS04550	COG2855	membrane
G3M63_RS04560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3M63_RS04580	COG2188	Transcriptional regulator
G3M63_RS04590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3M63_RS04615	COG3909	cytochrome
G3M63_RS04620	COG0659	secondary active sulfate transmembrane transporter activity
G3M63_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS04635	COG5002	protein histidine kinase activity
G3M63_RS04640	COG0745	RESPONSE REGULATOR receiver
G3M63_RS04675	COG0028	Belongs to the TPP enzyme family
G3M63_RS04680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3M63_RS04695	COG1024	Enoyl-CoA hydratase
G3M63_RS04700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3M63_RS04710	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS04715	COG0604	alcohol dehydrogenase
G3M63_RS04730	COG0133	tryptophan synthase activity
G3M63_RS04735	COG0159	tryptophan synthase activity
G3M63_RS04740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G3M63_RS04750	COG0009	L-threonylcarbamoyladenylate synthase
G3M63_RS04755	COG0758	DNA mediated transformation
G3M63_RS04760	COG1652	LysM domain
G3M63_RS04770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3M63_RS04775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G3M63_RS04780	COG0569	domain protein
G3M63_RS04785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G3M63_RS04800	COG2818	Glycosylase
G3M63_RS04835	COG0187	DNA topoisomerase II activity
G3M63_RS04840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G3M63_RS04850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3M63_RS04855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G3M63_RS04860	COG0594	ribonuclease P activity
G3M63_RS04865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G3M63_RS04870	COG0706	membrane insertase activity
G3M63_RS04875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G3M63_RS04880	COG1473	amidohydrolase
G3M63_RS04895	COG1192	Involved in chromosome partitioning
G3M63_RS04900	COG1475	DNA binding
G3M63_RS04905	COG3312	ion transport
G3M63_RS04910	COG0356	it plays a direct role in the translocation of protons across the membrane
G3M63_RS04920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3M63_RS04925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3M63_RS04935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G3M63_RS04945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3M63_RS04950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3M63_RS04955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3M63_RS04975	COG0523	cobalamin synthesis protein
G3M63_RS05000	COG0798	PFAM Bile acid sodium symporter
G3M63_RS05005	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS05015	COG0745	RESPONSE REGULATOR receiver
G3M63_RS05045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3M63_RS05065	COG5001	Diguanylate cyclase
G3M63_RS05065	COG5002	protein histidine kinase activity
G3M63_RS05065	COG3447	MASE1 domain protein
G3M63_RS05075	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
G3M63_RS05115	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
G3M63_RS05225	COG0745	RESPONSE REGULATOR receiver
G3M63_RS05235	COG2132	Multicopper oxidase
G3M63_RS05355	COG0582	viral genome integration into host DNA
G3M63_RS05395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3M63_RS05405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3M63_RS05435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3M63_RS05450	COG2226	methyltransferase
G3M63_RS05475	COG0789	Transcriptional regulator
G3M63_RS05490	COG0450	alkyl hydroperoxide reductase
G3M63_RS05525	COG0606	chelatase, subunit chli
G3M63_RS05530	COG2960	long-chain fatty acid transporting porin activity
G3M63_RS05535	COG0347	Belongs to the P(II) protein family
G3M63_RS05540	COG0004	ammonium transporteR
G3M63_RS05545	COG0432	Pfam Uncharacterised protein family UPF0047
G3M63_RS05560	COG0546	phosphoglycolate phosphatase activity
G3M63_RS05575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G3M63_RS05590	COG1965	Belongs to the frataxin family
G3M63_RS05600	COG0625	glutathione transferase activity
G3M63_RS05605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3M63_RS05620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3M63_RS05620	COG2813	Specifically methylates the guanine in position
G3M63_RS05625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3M63_RS05630	COG1872	DUF167
G3M63_RS05665	COG0540	Belongs to the ATCase OTCase family
G3M63_RS05670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G3M63_RS05675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G3M63_RS05680	COG1678	Uncharacterized ACR, COG1678
G3M63_RS05690	COG0189	ligase activity
G3M63_RS05720	COG2198	Histidine kinase
G3M63_RS05720	COG0784	Response regulator, receiver
G3M63_RS05720	COG0643	Histidine kinase
G3M63_RS05735	COG2205	protein histidine kinase activity
G3M63_RS05740	COG0745	RESPONSE REGULATOR receiver
G3M63_RS05745	COG2183	response to ionizing radiation
G3M63_RS05755	COG2918	glutathione biosynthetic process
G3M63_RS05770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G3M63_RS05780	COG3852	Histidine kinase
G3M63_RS05845	COG1490	D-aminoacyl-tRNA deacylase activity
G3M63_RS05875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3M63_RS05880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3M63_RS05885	COG0140	phosphoribosyl-ATP diphosphatase activity
G3M63_RS05890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G3M63_RS05905	COG2226	methyltransferase
G3M63_RS05940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G3M63_RS05945	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G3M63_RS05960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G3M63_RS05975	COG0281	malic enzyme
G3M63_RS05985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3M63_RS06025	COG0410	ABC transporter
G3M63_RS06055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G3M63_RS06055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G3M63_RS06060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G3M63_RS06110	COG0081	regulation of translation
G3M63_RS06120	COG0222	ribosome binding
G3M63_RS06125	COG0085	RNA polymerase activity
G3M63_RS06135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G3M63_RS06140	COG0049	tRNA binding
G3M63_RS06145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3M63_RS06155	COG0051	transcription antitermination factor activity, RNA binding
G3M63_RS06160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G3M63_RS06165	COG0088	Forms part of the polypeptide exit tunnel
G3M63_RS06170	COG0089	rRNA binding
G3M63_RS06175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G3M63_RS06180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G3M63_RS06185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G3M63_RS06190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G3M63_RS06195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G3M63_RS06200	COG0255	Belongs to the universal ribosomal protein uL29 family
G3M63_RS06210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G3M63_RS06215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G3M63_RS06220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G3M63_RS06230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G3M63_RS06235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G3M63_RS06240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G3M63_RS06245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G3M63_RS06255	COG0200	Binds to the 23S rRNA
G3M63_RS06265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G3M63_RS06275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G3M63_RS06280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G3M63_RS06285	COG0202	RNA polymerase activity
G3M63_RS06295	COG0753	catalase activity
G3M63_RS06305	COG2814	Major facilitator Superfamily
G3M63_RS06340	COG3278	Belongs to the heme-copper respiratory oxidase family
G3M63_RS06345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3M63_RS06350	COG0348	domain, Protein
G3M63_RS06355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3M63_RS06365	COG2072	flavoprotein involved in K transport
G3M63_RS06375	COG2144	transferase activity, transferring acyl groups
G3M63_RS06400	COG3604	Transcriptional regulator
G3M63_RS06460	COG3047	cAMP biosynthetic process
G3M63_RS06470	COG0811	peptide transport
G3M63_RS06475	COG0811	peptide transport
G3M63_RS06480	COG0848	biopolymer transport protein
G3M63_RS06495	COG3118	belongs to the thioredoxin family
G3M63_RS06500	COG2264	protein methyltransferase activity
G3M63_RS06510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3M63_RS06510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3M63_RS06515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G3M63_RS06530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G3M63_RS06545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G3M63_RS06550	COG3577	Aspartyl protease
G3M63_RS06555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3M63_RS06575	COG4206	TonB-dependent receptor
G3M63_RS06580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3M63_RS06585	COG0142	geranyltranstransferase activity
G3M63_RS06590	COG1722	exodeoxyribonuclease VII activity
G3M63_RS06595	COG0730	response to heat
G3M63_RS06600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G3M63_RS06615	COG1765	OsmC-like protein
G3M63_RS06620	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G3M63_RS06625	COG0537	adenosine 5'-monophosphoramidase activity
G3M63_RS06650	COG0316	Belongs to the HesB IscA family
G3M63_RS06660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G3M63_RS06665	COG0739	heme binding
G3M63_RS06670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G3M63_RS06705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G3M63_RS06710	COG4208	sulfate ABC transporter
G3M63_RS06715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3M63_RS06725	COG0019	diaminopimelate decarboxylase activity
G3M63_RS06735	COG2885	chlorophyll binding
G3M63_RS06740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G3M63_RS06745	COG1074	ATP-dependent DNA helicase activity
G3M63_RS06750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G3M63_RS06755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G3M63_RS06765	COG0405	Gamma-glutamyltransferase
G3M63_RS06775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G3M63_RS06805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G3M63_RS06820	COG1216	Glycosyl transferase, family 2
G3M63_RS06835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3M63_RS06860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3M63_RS06870	COG0489	protein tyrosine kinase activity
G3M63_RS06905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G3M63_RS06910	COG0733	neurotransmitter:sodium symporter activity
G3M63_RS06935	COG0497	DNA recombination
G3M63_RS06940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G3M63_RS06955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3M63_RS06965	COG0505	Belongs to the CarA family
G3M63_RS06970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G3M63_RS06990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G3M63_RS06995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3M63_RS07000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G3M63_RS07005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3M63_RS07010	COG0149	triose-phosphate isomerase activity
G3M63_RS07035	COG0195	Participates in both transcription termination and antitermination
G3M63_RS07040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3M63_RS07045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G3M63_RS07050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G3M63_RS07055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G3M63_RS07060	COG1185	polyribonucleotide nucleotidyltransferase activity
G3M63_RS07090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G3M63_RS07095	COG2323	membrane
G3M63_RS07105	COG2890	protein-(glutamine-N5) methyltransferase activity
G3M63_RS07110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3M63_RS07140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G3M63_RS07145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G3M63_RS07155	COG0617	tRNA 3'-terminal CCA addition
G3M63_RS07165	COG3852	Histidine kinase
G3M63_RS07175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3M63_RS07180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G3M63_RS07200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3M63_RS07205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G3M63_RS07230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3M63_RS07240	COG3098	single-species biofilm formation
G3M63_RS07250	COG0028	Belongs to the TPP enzyme family
G3M63_RS07260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G3M63_RS07265	COG1183	phosphatidylcholine synthase activity
G3M63_RS07295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3M63_RS07305	COG0456	acetyltransferase
G3M63_RS07310	COG0288	reversible hydration of carbon dioxide
G3M63_RS07315	COG0697	spore germination
G3M63_RS07320	COG0506	proline dehydrogenase activity
G3M63_RS07320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3M63_RS07320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3M63_RS07330	COG0668	transmembrane transport
G3M63_RS07335	COG0012	GTP binding
G3M63_RS07345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G3M63_RS07360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G3M63_RS07365	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G3M63_RS07380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G3M63_RS07390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3M63_RS07395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G3M63_RS07410	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
G3M63_RS07415	COG1090	epimerase
G3M63_RS07420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G3M63_RS07425	COG1280	lysine exporter protein (LysE YggA)
G3M63_RS07430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3M63_RS07465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G3M63_RS07475	COG0659	secondary active sulfate transmembrane transporter activity
G3M63_RS07495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G3M63_RS07495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G3M63_RS07500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3M63_RS07505	COG0154	amidase activity
G3M63_RS07510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3M63_RS07515	COG1077	Cell shape determining protein MreB Mrl
G3M63_RS07520	COG1792	Involved in formation and maintenance of cell shape
G3M63_RS07535	COG1530	ribonuclease E activity
G3M63_RS07545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3M63_RS07550	COG0312	modulator of DNA gyrase
G3M63_RS07555	COG0252	asparaginase activity
G3M63_RS07570	COG1131	(ABC) transporter
G3M63_RS07575	COG0842	Transport permease protein
G3M63_RS07590	COG0514	ATP-dependent DNA helicase (RecQ)
G3M63_RS07595	COG3387	PFAM Glycoside hydrolase 15-related
G3M63_RS07600	COG3081	Nucleoid-associated protein
G3M63_RS07605	COG0490	domain, Protein
G3M63_RS07605	COG0471	metal ion transport
G3M63_RS07610	COG0525	valine-tRNA ligase activity
G3M63_RS07640	COG1024	Enoyl-CoA hydratase
G3M63_RS07655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3M63_RS07675	COG0534	Mate efflux family protein
G3M63_RS07690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3M63_RS07695	COG4977	sequence-specific DNA binding
G3M63_RS07700	COG0702	epimerase
G3M63_RS07705	COG1451	nucleotide metabolic process
G3M63_RS07720	COG0602	queuosine metabolic process
G3M63_RS07730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G3M63_RS07735	COG0702	epimerase
G3M63_RS07750	COG1396	sequence-specific DNA binding
G3M63_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS07770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3M63_RS07775	COG0385	Bile acid
G3M63_RS07780	COG2072	flavoprotein involved in K transport
G3M63_RS07790	COG2851	Citrate transporter
G3M63_RS07825	COG3180	Ammonia monooxygenase
G3M63_RS07830	COG2272	Belongs to the type-B carboxylesterase lipase family
G3M63_RS07840	COG0651	ATP synthesis coupled electron transport
G3M63_RS07845	COG0651	ATP synthesis coupled electron transport
G3M63_RS07850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3M63_RS07880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3M63_RS07885	COG0625	glutathione transferase activity
G3M63_RS07895	COG3093	addiction module antidote protein HigA
G3M63_RS07905	COG4607	ABC-type enterochelin transport system periplasmic component
G3M63_RS07920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3M63_RS07925	COG0795	lipopolysaccharide-transporting ATPase activity
G3M63_RS07930	COG0795	lipopolysaccharide-transporting ATPase activity
G3M63_RS07945	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
G3M63_RS07950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3M63_RS07955	COG0477	Major facilitator Superfamily
G3M63_RS07960	COG1234	tRNA 3'-trailer cleavage
G3M63_RS07985	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G3M63_RS08020	COG3022	response to hydroperoxide
G3M63_RS08025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G3M63_RS08030	COG0513	Belongs to the DEAD box helicase family
G3M63_RS08040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3M63_RS08045	COG1196	nuclear chromosome segregation
G3M63_RS08045	COG3264	Mechanosensitive ion channel
G3M63_RS08050	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS08060	COG1040	competence protein
G3M63_RS08065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G3M63_RS08070	COG0156	8-amino-7-oxononanoate synthase activity
G3M63_RS08075	COG1073	alpha beta
G3M63_RS08075	COG2226	methyltransferase
G3M63_RS08095	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS08100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3M63_RS08110	COG3028	Belongs to the UPF0307 family
G3M63_RS08115	COG0312	modulator of DNA gyrase
G3M63_RS08125	COG1660	Displays ATPase and GTPase activities
G3M63_RS08145	COG1137	ATPase activity
G3M63_RS08150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G3M63_RS08160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G3M63_RS08170	COG1127	ABC transporter
G3M63_RS08175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3M63_RS08210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3M63_RS08215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3M63_RS08230	COG0175	sulfate reduction
G3M63_RS08250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G3M63_RS08265	COG1858	cytochrome C peroxidase
G3M63_RS08290	COG3313	Fe-S protein
G3M63_RS08295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G3M63_RS08300	COG4536	flavin adenine dinucleotide binding
G3M63_RS08310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G3M63_RS08315	COG0228	four-way junction DNA binding
G3M63_RS08320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G3M63_RS08330	COG0335	large ribosomal subunit rRNA binding
G3M63_RS08340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3M63_RS08355	COG3932	Exopolysaccharide synthesis, ExoD
G3M63_RS08375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3M63_RS08405	COG2943	transferase activity, transferring hexosyl groups
G3M63_RS08410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3M63_RS08445	COG1285	pathogenesis
G3M63_RS08450	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G3M63_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS08465	COG0366	Alpha amylase catalytic
G3M63_RS08470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3M63_RS08475	COG0392	lysyltransferase activity
G3M63_RS08480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3M63_RS08485	COG3568	Endonuclease Exonuclease Phosphatase
G3M63_RS08515	COG1640	4-alpha-glucanotransferase
G3M63_RS08520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3M63_RS08525	COG0297	glycogen (starch) synthase activity
G3M63_RS08530	COG1546	Belongs to the CinA family
G3M63_RS08530	COG1058	Belongs to the CinA family
G3M63_RS08540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G3M63_RS08545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G3M63_RS08565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G3M63_RS08580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G3M63_RS08585	COG1024	Enoyl-CoA hydratase
G3M63_RS08595	COG0354	folic acid binding
G3M63_RS08635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3M63_RS08640	COG0481	GTPase activity
G3M63_RS08645	COG0681	Belongs to the peptidase S26 family
G3M63_RS08655	COG0571	ribonuclease III activity
G3M63_RS08660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G3M63_RS08680	COG5002	protein histidine kinase activity
G3M63_RS08680	COG0784	Response regulator, receiver
G3M63_RS08680	COG2205	protein histidine kinase activity
G3M63_RS08690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3M63_RS08695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G3M63_RS08700	COG3956	TIGRFAM MazG family protein
G3M63_RS08710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G3M63_RS08720	COG1214	PFAM Peptidase M22, glycoprotease
G3M63_RS08730	COG0742	ribosomal rna small subunit methyltransferase
G3M63_RS08735	COG2937	Belongs to the GPAT DAPAT family
G3M63_RS08740	COG1131	(ABC) transporter
G3M63_RS08760	COG3118	belongs to the thioredoxin family
G3M63_RS08770	COG2226	methyltransferase
G3M63_RS08775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3M63_RS08785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G3M63_RS08790	COG2171	N-acyltransferase activity
G3M63_RS08795	COG1393	Belongs to the ArsC family
G3M63_RS08800	COG0436	Aminotransferase
G3M63_RS08805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G3M63_RS08810	COG0024	Methionine aminopeptidase
G3M63_RS08815	COG0052	Belongs to the universal ribosomal protein uS2 family
G3M63_RS08820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G3M63_RS08830	COG0233	cytoplasmic translational termination
G3M63_RS08835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3M63_RS08845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G3M63_RS08865	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3M63_RS08870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3M63_RS08875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3M63_RS08880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3M63_RS08885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G3M63_RS08895	COG0825	malonyl-CoA metabolic process
G3M63_RS08900	COG0037	tRNA processing
G3M63_RS08905	COG0504	CTP synthase activity
G3M63_RS08910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G3M63_RS08915	COG0148	phosphopyruvate hydratase activity
G3M63_RS08925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G3M63_RS08940	COG0587	DNA-directed DNA polymerase activity
G3M63_RS08950	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS08955	COG1024	Enoyl-CoA hydratase
G3M63_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS08995	COG1053	succinate dehydrogenase
G3M63_RS09020	COG2146	nitrite reductase [NAD(P)H] activity
G3M63_RS09050	COG4638	Rieske (2fe-2S)
G3M63_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS09085	COG2130	NADP-dependent
G3M63_RS09100	COG2130	NADP-dependent
G3M63_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS09150	COG3976	FMN-binding domain protein
G3M63_RS09150	COG1053	succinate dehydrogenase
G3M63_RS09160	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G3M63_RS09165	COG4638	Rieske (2fe-2S)
G3M63_RS09175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3M63_RS09180	COG0022	dehydrogenase e1 component
G3M63_RS09190	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3M63_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS09200	COG3226	Transcriptional regulator
G3M63_RS09210	COG0183	Belongs to the thiolase family
G3M63_RS09215	COG4638	Rieske (2fe-2S)
G3M63_RS09220	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS09225	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS09230	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS09245	COG1024	Enoyl-CoA hydratase
G3M63_RS09250	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS09255	COG0183	Belongs to the thiolase family
G3M63_RS09265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3M63_RS09275	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS09280	COG0745	RESPONSE REGULATOR receiver
G3M63_RS09280	COG2205	protein histidine kinase activity
G3M63_RS09280	COG4191	Histidine kinase
G3M63_RS09285	COG4566	intracellular signal transduction
G3M63_RS09300	COG3706	GGDEF domain
G3M63_RS09305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3M63_RS09335	COG3012	SEC-C Motif Domain Protein
G3M63_RS09345	COG1199	ATP-dependent helicase activity
G3M63_RS09360	COG0300	oxidoreductase activity
G3M63_RS09370	COG1946	Acyl-CoA thioesterase
G3M63_RS09380	COG1368	sulfuric ester hydrolase activity
G3M63_RS09390	COG1115	amino acid carrier protein
G3M63_RS09405	COG3725	Membrane protein required for beta-lactamase induction
G3M63_RS09415	COG2096	Adenosyltransferase
G3M63_RS09425	COG0745	RESPONSE REGULATOR receiver
G3M63_RS09430	COG1666	GTP binding
G3M63_RS09435	COG0668	transmembrane transport
G3M63_RS09450	COG3695	enzyme binding
G3M63_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS09480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3M63_RS09485	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS09495	COG0840	transmembrane signaling receptor activity
G3M63_RS09500	COG3030	protein affecting phage T7 exclusion by the F plasmid
G3M63_RS09505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3M63_RS09515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3M63_RS09525	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS09540	COG1309	transcriptional regulator
G3M63_RS09545	COG1546	Belongs to the CinA family
G3M63_RS09550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G3M63_RS09555	COG2137	regulation of response to DNA damage stimulus
G3M63_RS09565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3M63_RS09575	COG1414	Transcriptional regulator
G3M63_RS09580	COG2031	fatty acid transporter
G3M63_RS09600	COG0784	Response regulator, receiver
G3M63_RS09600	COG2198	Histidine kinase
G3M63_RS09600	COG2205	protein histidine kinase activity
G3M63_RS09625	COG1024	Enoyl-CoA hydratase
G3M63_RS09625	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS09635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G3M63_RS09645	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G3M63_RS09660	COG0732	type I restriction modification DNA specificity domain
G3M63_RS09665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G3M63_RS09690	COG0789	Transcriptional regulator
G3M63_RS09755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3M63_RS09760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3M63_RS09765	COG4974	Belongs to the 'phage' integrase family
G3M63_RS09805	COG2132	Multicopper oxidase
G3M63_RS09835	COG2116	formate transmembrane transporter activity
G3M63_RS09865	COG0668	transmembrane transport
G3M63_RS09870	COG0840	transmembrane signaling receptor activity
G3M63_RS09880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3M63_RS09890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3M63_RS09900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3M63_RS09910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3M63_RS09935	COG0402	S-adenosylhomocysteine deaminase activity
G3M63_RS09940	COG1309	transcriptional regulator
G3M63_RS09960	COG1129	ABC transporter
G3M63_RS09970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3M63_RS09985	COG2351	hydroxyisourate hydrolase activity
G3M63_RS09990	COG0402	S-adenosylhomocysteine deaminase activity
G3M63_RS10025	COG2271	Major facilitator Superfamily
G3M63_RS10030	COG2233	PERMEase
G3M63_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3M63_RS10080	COG0642	Histidine kinase
G3M63_RS10095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3M63_RS10110	COG1999	signal sequence binding
G3M63_RS10120	COG2321	neutral zinc metallopeptidase
G3M63_RS10135	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS10155	COG1024	Enoyl-CoA hydratase
G3M63_RS10155	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS10165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G3M63_RS10170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G3M63_RS10180	COG0628	permease
G3M63_RS10200	COG1393	Belongs to the ArsC family
G3M63_RS10210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3M63_RS10235	COG2900	Belongs to the SlyX family
G3M63_RS10240	COG1278	Cold shock
G3M63_RS10245	COG0783	Belongs to the Dps family
G3M63_RS10250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G3M63_RS10260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G3M63_RS10265	COG0632	four-way junction helicase activity
G3M63_RS10270	COG2255	four-way junction helicase activity
G3M63_RS10275	COG0824	Thioesterase
G3M63_RS10295	COG0823	Involved in the tonB-independent uptake of proteins
G3M63_RS10300	COG2885	chlorophyll binding
G3M63_RS10305	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
G3M63_RS10330	COG3685	Protein conserved in bacteria
G3M63_RS10370	COG0425	Belongs to the sulfur carrier protein TusA family
G3M63_RS10380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3M63_RS10385	COG2716	regulation of RNA biosynthetic process
G3M63_RS10390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3M63_RS10400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3M63_RS10405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G3M63_RS10490	COG1024	Enoyl-CoA hydratase
G3M63_RS10495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3M63_RS10500	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS10510	COG0583	DNA-binding transcription factor activity
G3M63_RS10545	COG1024	Enoyl-CoA hydratase
G3M63_RS10550	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10575	COG1609	Transcriptional regulator
G3M63_RS10575	COG2207	Transcriptional regulator
G3M63_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10630	COG2124	cytochrome p450
G3M63_RS10640	COG2264	protein methyltransferase activity
G3M63_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3M63_RS10690	COG2814	Major facilitator Superfamily
G3M63_RS10710	COG0840	transmembrane signaling receptor activity
G3M63_RS10725	COG0840	transmembrane signaling receptor activity
G3M63_RS10735	COG2124	cytochrome p450
G3M63_RS10750	COG1012	belongs to the aldehyde dehydrogenase family
G3M63_RS10780	COG2814	Major facilitator Superfamily
G3M63_RS10805	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3M63_RS10835	COG1309	transcriptional regulator
G3M63_RS10845	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3M63_RS10850	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS10865	COG0386	Belongs to the glutathione peroxidase family
G3M63_RS10870	COG2124	cytochrome p450
G3M63_RS10880	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS10890	COG1024	Enoyl-CoA hydratase
G3M63_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS10915	COG4221	oxidoreductase activity
G3M63_RS10940	COG0582	viral genome integration into host DNA
G3M63_RS10970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3M63_RS11035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3M63_RS11040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G3M63_RS11045	COG1120	ATPase activity
G3M63_RS11050	COG4615	Cyclic peptide transporter
G3M63_RS11095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3M63_RS11100	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G3M63_RS11115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3M63_RS11120	COG1012	belongs to the aldehyde dehydrogenase family
G3M63_RS11125	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS11150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G3M63_RS11150	COG2755	lipolytic protein G-D-S-L family
G3M63_RS11160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3M63_RS11165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3M63_RS11175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3M63_RS11225	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G3M63_RS11255	COG0545	Peptidyl-prolyl cis-trans isomerase
G3M63_RS11265	COG4221	oxidoreductase activity
G3M63_RS11265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G3M63_RS11265	COG3321	synthase
G3M63_RS11265	COG0604	alcohol dehydrogenase
G3M63_RS11270	COG1362	aminopeptidase activity
G3M63_RS11275	COG0564	pseudouridine synthase activity
G3M63_RS11280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G3M63_RS11285	COG2894	cell division
G3M63_RS11290	COG0850	regulation of cytokinetic process
G3M63_RS11295	COG1560	Kdo2-lipid A biosynthetic process
G3M63_RS11335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G3M63_RS11350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3M63_RS11355	COG0527	aspartate kinase activity
G3M63_RS11360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G3M63_RS11375	COG2239	Acts as a magnesium transporter
G3M63_RS11380	COG3630	sodium ion export across plasma membrane
G3M63_RS11385	COG0511	ligase activity, forming carbon-carbon bonds
G3M63_RS11385	COG5016	pyruvate
G3M63_RS11390	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
G3M63_RS11405	COG1414	Transcriptional regulator
G3M63_RS11435	COG2814	Major facilitator Superfamily
G3M63_RS11440	COG4948	Mandelate Racemase Muconate Lactonizing
G3M63_RS11445	COG4829	muconolactone delta-isomerase
G3M63_RS11450	COG3485	protocatechuate 3,4-dioxygenase
G3M63_RS11455	COG3135	benzoate transporter
G3M63_RS11460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G3M63_RS11465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G3M63_RS11475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3M63_RS11485	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G3M63_RS11505	COG0835	chemotaxis
G3M63_RS11505	COG0784	Response regulator, receiver
G3M63_RS11510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3M63_RS11515	COG1815	bacterial-type flagellum-dependent cell motility
G3M63_RS11525	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G3M63_RS11530	COG1749	Flagellar hook protein flgE
G3M63_RS11535	COG4787	bacterial-type flagellum-dependent cell motility
G3M63_RS11540	COG4786	Flagellar basal body rod
G3M63_RS11550	COG1706	bacterial-type flagellum-dependent cell motility
G3M63_RS11560	COG1256	bacterial-type flagellum assembly
G3M63_RS11575	COG2217	Heavy metal translocating P-type atpase
G3M63_RS11580	COG3608	succinylglutamate desuccinylase aspartoacylase
G3M63_RS11580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3M63_RS11585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3M63_RS11595	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3M63_RS11600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3M63_RS11610	COG0500	methyltransferase
G3M63_RS11620	COG5002	protein histidine kinase activity
G3M63_RS11625	COG2204	response regulator
G3M63_RS11635	COG5487	UPF0391 membrane protein
G3M63_RS11640	COG0438	transferase activity, transferring glycosyl groups
G3M63_RS11665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G3M63_RS11670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G3M63_RS11690	COG1902	pentaerythritol trinitrate reductase activity
G3M63_RS11695	COG0640	Transcriptional regulator
G3M63_RS11700	COG0477	Major facilitator Superfamily
G3M63_RS11705	COG0753	catalase activity
G3M63_RS11720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G3M63_RS11730	COG3089	Belongs to the UPF0270 family
G3M63_RS11740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3M63_RS11740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G3M63_RS11745	COG2154	pterin-4-alpha-carbinolamine dehydratase
G3M63_RS11750	COG0697	spore germination
G3M63_RS11765	COG0271	Belongs to the BolA IbaG family
G3M63_RS11800	COG0514	ATP-dependent DNA helicase (RecQ)
G3M63_RS11805	COG1752	Esterase of the alpha-beta hydrolase superfamily
G3M63_RS11845	COG0745	RESPONSE REGULATOR receiver
G3M63_RS11855	COG2350	Protein conserved in bacteria
G3M63_RS11860	COG0613	PHP domain protein
G3M63_RS11865	COG0009	L-threonylcarbamoyladenylate synthase
G3M63_RS11870	COG0180	Tryptophanyl-tRNA synthetase
G3M63_RS11880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G3M63_RS11890	COG3706	GGDEF domain
G3M63_RS11895	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS11910	COG0402	S-adenosylhomocysteine deaminase activity
G3M63_RS11915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G3M63_RS11925	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G3M63_RS11935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3M63_RS11940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G3M63_RS11945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G3M63_RS11955	COG0776	regulation of translation
G3M63_RS11965	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G3M63_RS11985	COG2211	Major facilitator Superfamily
G3M63_RS11995	COG4221	oxidoreductase activity
G3M63_RS12010	COG3842	ATPase activity
G3M63_RS12020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3M63_RS12025	COG0303	'Molybdopterin
G3M63_RS12030	COG0521	Mo-molybdopterin cofactor biosynthetic process
G3M63_RS12035	COG0746	molybdenum cofactor guanylyltransferase activity
G3M63_RS12055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3M63_RS12060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G3M63_RS12070	COG2130	NADP-dependent
G3M63_RS12080	COG0784	Response regulator, receiver
G3M63_RS12080	COG2205	protein histidine kinase activity
G3M63_RS12085	COG2197	response regulator
G3M63_RS12100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G3M63_RS12105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3M63_RS12120	COG2217	Heavy metal translocating P-type atpase
G3M63_RS12130	COG0348	domain, Protein
G3M63_RS12135	COG2010	Cytochrome c
G3M63_RS12150	COG3278	Belongs to the heme-copper respiratory oxidase family
G3M63_RS12160	COG0840	transmembrane signaling receptor activity
G3M63_RS12165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3M63_RS12170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G3M63_RS12175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3M63_RS12180	COG0489	protein tyrosine kinase activity
G3M63_RS12185	COG0717	Belongs to the dCTP deaminase family
G3M63_RS12215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3M63_RS12260	COG1611	Belongs to the LOG family
G3M63_RS12265	COG2072	flavoprotein involved in K transport
G3M63_RS12270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G3M63_RS12290	COG0530	calcium, potassium:sodium antiporter activity
G3M63_RS12300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G3M63_RS12320	COG2860	membrane
G3M63_RS12340	COG3501	Rhs element vgr protein
G3M63_RS12350	COG0826	peptidase U32
G3M63_RS12360	COG2267	carboxylic ester hydrolase activity
G3M63_RS12385	COG4772	TonB-dependent receptor
G3M63_RS12390	COG3706	GGDEF domain
G3M63_RS12395	COG4191	Histidine kinase
G3M63_RS12395	COG0784	Response regulator, receiver
G3M63_RS12400	COG2205	protein histidine kinase activity
G3M63_RS12410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G3M63_RS12455	COG1944	ATP diphosphatase activity
G3M63_RS12470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G3M63_RS12520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3M63_RS12560	COG1136	(ABC) transporter
G3M63_RS12575	COG2226	methyltransferase
G3M63_RS12580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3M63_RS12585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3M63_RS12585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3M63_RS12590	COG0745	RESPONSE REGULATOR receiver
G3M63_RS12595	COG2205	protein histidine kinase activity
G3M63_RS12620	COG0583	DNA-binding transcription factor activity
G3M63_RS12625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G3M63_RS12630	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
G3M63_RS12655	COG3101	peptidyl-lysine hydroxylation
G3M63_RS12660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3M63_RS12685	COG0436	Aminotransferase
G3M63_RS12690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3M63_RS12695	COG0386	Belongs to the glutathione peroxidase family
G3M63_RS12700	COG0784	Response regulator, receiver
G3M63_RS12700	COG2205	protein histidine kinase activity
G3M63_RS12700	COG5002	protein histidine kinase activity
G3M63_RS12735	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS12740	COG2814	Major facilitator Superfamily
G3M63_RS12745	COG1131	(ABC) transporter
G3M63_RS12750	COG0842	Transport permease protein
G3M63_RS12755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3M63_RS12755	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3M63_RS12765	COG2853	Lipoprotein
G3M63_RS12780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G3M63_RS12785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3M63_RS12840	COG2815	serine threonine protein kinase
G3M63_RS12840	COG0515	serine threonine protein kinase
G3M63_RS12880	COG3501	Rhs element vgr protein
G3M63_RS12885	COG2204	response regulator
G3M63_RS12940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3M63_RS12945	COG0583	DNA-binding transcription factor activity
G3M63_RS12950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3M63_RS12975	COG1982	Orn Lys Arg decarboxylase major
G3M63_RS12985	COG3123	guanosine phosphorylase activity
G3M63_RS12995	COG2084	Dehydrogenase
G3M63_RS13015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G3M63_RS13045	COG0045	succinate-CoA ligase (ADP-forming) activity
G3M63_RS13085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3M63_RS13095	COG0243	molybdopterin cofactor binding
G3M63_RS13100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3M63_RS13105	COG2223	nitrite transmembrane transporter activity
G3M63_RS13120	COG0129	dihydroxy-acid dehydratase activity
G3M63_RS13170	COG4770	biotin carboxylase activity
G3M63_RS13220	COG1132	(ABC) transporter
G3M63_RS13230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G3M63_RS13235	COG3091	SprT-like family
G3M63_RS13260	COG0037	tRNA processing
G3M63_RS13270	COG0791	NLP P60 protein
G3M63_RS13295	COG2056	Na+-H+ antiporter family
G3M63_RS13300	COG0137	argininosuccinate synthase activity
G3M63_RS13325	COG2983	Belongs to the UPF0260 family
G3M63_RS13330	COG2853	Lipoprotein
G3M63_RS13350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G3M63_RS13355	COG4660	Part of a membrane complex involved in electron transport
G3M63_RS13360	COG4659	FMN binding
G3M63_RS13365	COG4658	electron transport chain
G3M63_RS13375	COG2878	Part of a membrane complex involved in electron transport
G3M63_RS13380	COG4657	Part of a membrane complex involved in electron transport
G3M63_RS13385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3M63_RS13385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3M63_RS13410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3M63_RS13440	COG1794	racemase activity, acting on amino acids and derivatives
G3M63_RS13455	COG0835	chemotaxis
G3M63_RS13455	COG0784	Response regulator, receiver
G3M63_RS13470	COG0513	Belongs to the DEAD box helicase family
G3M63_RS13485	COG3171	Protein conserved in bacteria
G3M63_RS13490	COG1704	LemA family
G3M63_RS13495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G3M63_RS13520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3M63_RS13535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3M63_RS13570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3M63_RS13595	COG5507	3-demethylubiquinone-9 3-methyltransferase
G3M63_RS13600	COG3795	YCII-related domain
G3M63_RS13605	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G3M63_RS13610	COG4941	Belongs to the sigma-70 factor family
G3M63_RS13615	COG0436	Aminotransferase
G3M63_RS13620	COG0154	amidase activity
G3M63_RS13635	COG0473	3-isopropylmalate dehydrogenase activity
G3M63_RS13645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G3M63_RS13660	COG1132	(ABC) transporter
G3M63_RS13665	COG2814	Major facilitator Superfamily
G3M63_RS13675	COG1921	L-seryl-tRNASec selenium transferase activity
G3M63_RS13685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3M63_RS13690	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS13695	COG5002	protein histidine kinase activity
G3M63_RS13695	COG2205	protein histidine kinase activity
G3M63_RS13695	COG0784	Response regulator, receiver
G3M63_RS13710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3M63_RS13720	COG2062	phosphohistidine phosphatase, SixA
G3M63_RS13750	COG0709	Synthesizes selenophosphate from selenide and ATP
G3M63_RS13755	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G3M63_RS13780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G3M63_RS13790	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G3M63_RS13810	COG0583	DNA-binding transcription factor activity
G3M63_RS13815	COG3134	Outer membrane lipoprotein
G3M63_RS13835	COG0066	3-isopropylmalate dehydratase activity
G3M63_RS13840	COG2226	methyltransferase
G3M63_RS13870	COG0135	phosphoribosylanthranilate isomerase activity
G3M63_RS13880	COG0159	tryptophan synthase activity
G3M63_RS13890	COG0285	dihydrofolate synthase activity
G3M63_RS13900	COG1286	toxin biosynthetic process
G3M63_RS13920	COG1596	polysaccharide export
G3M63_RS13920	COG1555	photosystem II stabilization
G3M63_RS13925	COG0840	transmembrane signaling receptor activity
G3M63_RS13935	COG3100	YcgL domain-containing protein
G3M63_RS13945	COG3530	Putative quorum-sensing-regulated virulence factor
G3M63_RS13950	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS13960	COG3106	COG3106 Predicted ATPase
G3M63_RS13980	COG0500	methyltransferase
G3M63_RS13985	COG2226	methyltransferase
G3M63_RS13995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3M63_RS14000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3M63_RS14005	COG1770	oligopeptidase
G3M63_RS14020	COG1278	Cold shock
G3M63_RS14030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G3M63_RS14040	COG0542	response to heat
G3M63_RS14050	COG2030	dehydratase
G3M63_RS14055	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS14065	COG1643	Atp-dependent helicase
G3M63_RS14100	COG0583	DNA-binding transcription factor activity
G3M63_RS14120	COG0556	nucleotide-excision repair
G3M63_RS14135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G3M63_RS14145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G3M63_RS14160	COG0072	phenylalanine-tRNA ligase activity
G3M63_RS14165	COG0776	regulation of translation
G3M63_RS14190	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
G3M63_RS14200	COG2207	Transcriptional regulator
G3M63_RS14200	COG4753	response regulator
G3M63_RS14235	COG0656	L-ascorbic acid biosynthetic process
G3M63_RS14275	COG2723	6-phospho-beta-galactosidase activity
G3M63_RS14280	COG1132	(ABC) transporter
G3M63_RS14310	COG1064	alcohol dehydrogenase
G3M63_RS14315	COG0420	3'-5' exonuclease activity
G3M63_RS14335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G3M63_RS14345	COG2067	long-chain fatty acid transport protein
G3M63_RS14460	COG0826	peptidase U32
G3M63_RS14465	COG0826	peptidase U32
G3M63_RS14470	COG3154	lipid carrier protein
G3M63_RS14480	COG2197	response regulator
G3M63_RS14485	COG3850	Histidine kinase
G3M63_RS14515	COG2010	Cytochrome c
G3M63_RS14520	COG0714	Associated with various cellular activities
G3M63_RS14525	COG0348	domain, Protein
G3M63_RS14525	COG3901	Regulator of nitric oxide reductase transcription
G3M63_RS14530	COG4263	nitrous-oxide reductase activity
G3M63_RS14545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G3M63_RS14560	COG2832	Protein of unknown function (DUF454)
G3M63_RS14565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3M63_RS14575	COG0714	Associated with various cellular activities
G3M63_RS14580	COG3256	nitric oxide reductase
G3M63_RS14585	COG2010	Cytochrome c
G3M63_RS14605	COG3604	Transcriptional regulator
G3M63_RS14610	COG3278	Belongs to the heme-copper respiratory oxidase family
G3M63_RS14620	COG0517	IMP dehydrogenase activity
G3M63_RS14620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G3M63_RS14620	COG0617	tRNA 3'-terminal CCA addition
G3M63_RS14625	COG0583	DNA-binding transcription factor activity
G3M63_RS14635	COG1295	ribonuclease BN
G3M63_RS14675	COG3360	Dodecin
G3M63_RS14680	COG0517	IMP dehydrogenase activity
G3M63_RS14685	COG0676	glucose-6-phosphate 1-epimerase activity
G3M63_RS14715	COG2911	Protein conserved in bacteria
G3M63_RS14720	COG0729	surface antigen
G3M63_RS14725	COG0708	Exodeoxyribonuclease III
G3M63_RS14730	COG0542	response to heat
G3M63_RS14735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G3M63_RS14740	COG1278	Cold shock
G3M63_RS14755	COG0482	sulfurtransferase activity
G3M63_RS14760	COG2915	High frequency lysogenization protein hflD homolog
G3M63_RS14775	COG2850	peptidyl-arginine hydroxylation
G3M63_RS14810	COG0668	transmembrane transport
G3M63_RS14820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3M63_RS14830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G3M63_RS14835	COG0583	DNA-binding transcription factor activity
G3M63_RS14840	COG4771	TonB-dependent receptor
G3M63_RS14845	COG3135	benzoate transporter
G3M63_RS14870	COG2166	iron-sulfur cluster assembly
G3M63_RS14890	COG0719	Fe-S assembly protein
G3M63_RS14895	COG0396	ATPase activity
G3M63_RS14900	COG0719	Fe-S assembly protein
G3M63_RS14920	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G3M63_RS14940	COG1115	amino acid carrier protein
G3M63_RS14945	COG0215	cysteine-tRNA ligase activity
G3M63_RS14950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3M63_RS14955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G3M63_RS14960	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3M63_RS14980	COG0727	PFAM Uncharacterised protein family (UPF0153)
G3M63_RS15015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3M63_RS15015	COG0519	Catalyzes the synthesis of GMP from XMP
G3M63_RS15025	COG0590	tRNA wobble adenosine to inosine editing
G3M63_RS15030	COG0628	permease
G3M63_RS15045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3M63_RS15050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3M63_RS15060	COG3058	Necessary for formate dehydrogenase activity
G3M63_RS15065	COG2864	formate dehydrogenase
G3M63_RS15070	COG0437	4 iron, 4 sulfur cluster binding
G3M63_RS15085	COG3276	selenocysteine insertion sequence binding
G3M63_RS15110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3M63_RS15120	COG1696	Membrane protein involved in D-alanine export
G3M63_RS15135	COG5654	RES domain protein
G3M63_RS15150	COG0789	Transcriptional regulator
G3M63_RS15155	COG1366	Belongs to the anti-sigma-factor antagonist family
G3M63_RS15155	COG2202	Pas domain
G3M63_RS15165	COG4251	negative regulation of phosphorylation
G3M63_RS15165	COG3706	GGDEF domain
G3M63_RS15165	COG5001	Diguanylate cyclase
G3M63_RS15165	COG2203	Gaf domain
G3M63_RS15175	COG0789	Transcriptional regulator
G3M63_RS15185	COG2135	peptidase activity
G3M63_RS15190	COG4191	Histidine kinase
G3M63_RS15190	COG0784	Response regulator, receiver
G3M63_RS15195	COG2205	protein histidine kinase activity
G3M63_RS15205	COG2172	sigma factor antagonist activity
G3M63_RS15210	COG1366	Belongs to the anti-sigma-factor antagonist family
G3M63_RS15215	COG1366	Belongs to the anti-sigma-factor antagonist family
G3M63_RS15240	COG2132	Multicopper oxidase
G3M63_RS15260	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3M63_RS15275	COG2272	Belongs to the type-B carboxylesterase lipase family
G3M63_RS15320	COG1566	PFAM secretion protein HlyD family protein
G3M63_RS15335	COG0667	Aldo Keto reductase
G3M63_RS15340	COG0656	L-ascorbic acid biosynthetic process
G3M63_RS15345	COG1902	pentaerythritol trinitrate reductase activity
G3M63_RS15350	COG0604	alcohol dehydrogenase
G3M63_RS15360	COG0604	alcohol dehydrogenase
G3M63_RS15370	COG0583	DNA-binding transcription factor activity
G3M63_RS15375	COG2814	Major facilitator Superfamily
G3M63_RS15385	COG1012	belongs to the aldehyde dehydrogenase family
G3M63_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS15400	COG3284	Transcriptional regulator
G3M63_RS15405	COG1942	4-Oxalocrotonate Tautomerase
G3M63_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS15430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3M63_RS15435	COG0583	DNA-binding transcription factor activity
G3M63_RS15445	COG3276	selenocysteine insertion sequence binding
G3M63_RS15465	COG1739	Uncharacterized protein family UPF0029
G3M63_RS15495	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G3M63_RS15515	COG2197	response regulator
G3M63_RS15520	COG2207	Transcriptional regulator
G3M63_RS15525	COG1741	Belongs to the pirin family
G3M63_RS15545	COG1012	belongs to the aldehyde dehydrogenase family
G3M63_RS15555	COG1741	Belongs to the pirin family
G3M63_RS15560	COG1335	isochorismatase
G3M63_RS15570	COG2207	Transcriptional regulator
G3M63_RS15590	COG0583	DNA-binding transcription factor activity
G3M63_RS15650	COG2920	part of a sulfur-relay system
G3M63_RS15660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3M63_RS15675	COG0848	biopolymer transport protein
G3M63_RS15680	COG0811	peptide transport
G3M63_RS15705	COG0003	Pfam Anion-transporting ATPase
G3M63_RS15715	COG1966	Carbon starvation protein
G3M63_RS15720	COG3040	lipid binding
G3M63_RS15725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3M63_RS15725	COG0519	Catalyzes the synthesis of GMP from XMP
G3M63_RS15730	COG0598	Magnesium transport protein CorA
G3M63_RS15735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3M63_RS15735	COG1648	precorrin-2 dehydrogenase activity
G3M63_RS15740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G3M63_RS15745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G3M63_RS15750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G3M63_RS15755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G3M63_RS15760	COG1674	ftsk spoiiie
G3M63_RS15765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G3M63_RS15770	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G3M63_RS15775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G3M63_RS15795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3M63_RS15875	COG2824	Alkylphosphonate utilization operon protein PhnA
G3M63_RS15880	COG0217	transcriptional regulatory protein
G3M63_RS15900	COG0714	Associated with various cellular activities
G3M63_RS15915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3M63_RS15920	COG1322	Protein conserved in bacteria
G3M63_RS15950	COG2272	Belongs to the type-B carboxylesterase lipase family
G3M63_RS15965	COG0084	hydrolase, TatD family'
G3M63_RS16030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G3M63_RS16035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G3M63_RS16040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3M63_RS16045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3M63_RS16050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3M63_RS16065	COG0416	fatty acid biosynthetic process
G3M63_RS16070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G3M63_RS16075	COG1399	metal-binding, possibly nucleic acid-binding protein
G3M63_RS16080	COG0424	maF-like protein
G3M63_RS16085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G3M63_RS16085	COG0616	signal peptide processing
G3M63_RS16090	COG0546	phosphoglycolate phosphatase activity
G3M63_RS16100	COG1530	ribonuclease E activity
G3M63_RS16105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G3M63_RS16110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3M63_RS16115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G3M63_RS16120	COG2835	tetraacyldisaccharide 4'-kinase activity
G3M63_RS16125	COG1663	tetraacyldisaccharide 4'-kinase activity
G3M63_RS16130	COG0848	biopolymer transport protein
G3M63_RS16135	COG0811	peptide transport
G3M63_RS16140	COG0658	competence protein
G3M63_RS16140	COG2333	competence protein COMEC
G3M63_RS16170	COG0584	glycerophosphoryl diester phosphodiesterase
G3M63_RS16175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3M63_RS16195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
G3M63_RS16210	COG1805	sodium ion transport
G3M63_RS16225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G3M63_RS16290	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3M63_RS16290	COG1024	Enoyl-CoA hydratase
G3M63_RS16300	COG0589	response to stress
G3M63_RS16315	COG0835	chemotaxis
G3M63_RS16315	COG0784	Response regulator, receiver
G3M63_RS16320	COG0316	Belongs to the HesB IscA family
G3M63_RS16320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G3M63_RS16340	COG0534	Mate efflux family protein
G3M63_RS16350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3M63_RS16360	COG0604	alcohol dehydrogenase
G3M63_RS16365	COG0616	signal peptide processing
G3M63_RS16380	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS16390	COG2816	NAD+ diphosphatase activity
G3M63_RS16400	COG1024	Enoyl-CoA hydratase
G3M63_RS16410	COG0328	RNA-DNA hybrid ribonuclease activity
G3M63_RS16420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3M63_RS16425	COG1388	LysM domain
G3M63_RS16425	COG0741	lytic transglycosylase activity
G3M63_RS16435	COG4166	transmembrane transport
G3M63_RS16440	COG4174	ABC transporter (Permease)
G3M63_RS16445	COG4239	(ABC) transporter, permease
G3M63_RS16450	COG4172	Belongs to the ABC transporter superfamily
G3M63_RS16460	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS16465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3M63_RS16475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3M63_RS16480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G3M63_RS16490	COG0544	peptidyl-prolyl cis-trans isomerase activity
G3M63_RS16545	COG1802	Transcriptional regulator
G3M63_RS16555	COG0189	ligase activity
G3M63_RS16585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G3M63_RS16600	COG2610	gluconate transmembrane transporter activity
G3M63_RS16610	COG1388	LysM domain
G3M63_RS16610	COG1376	ErfK ybiS ycfS ynhG family protein
G3M63_RS16625	COG4181	ATPase activity
G3M63_RS16630	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G3M63_RS16640	COG0435	Glutathione S-transferase
G3M63_RS16660	COG0116	Belongs to the methyltransferase superfamily
G3M63_RS16660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G3M63_RS16665	COG3130	regulation of translation
G3M63_RS16685	COG0714	Associated with various cellular activities
G3M63_RS16700	COG2304	oxidoreductase activity
G3M63_RS16715	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS16730	COG0308	aminopeptidase N
G3M63_RS16740	COG3139	Protein of unknown function (DUF1315)
G3M63_RS16745	COG0705	Rhomboid family
G3M63_RS16750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G3M63_RS16770	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3M63_RS16770	COG1902	pentaerythritol trinitrate reductase activity
G3M63_RS16790	COG3383	formate dehydrogenase (NAD+) activity
G3M63_RS16815	COG1309	transcriptional regulator
G3M63_RS16825	COG2989	Protein conserved in bacteria
G3M63_RS16850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G3M63_RS16855	COG2814	Major facilitator Superfamily
G3M63_RS16860	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS16875	COG3048	D-serine ammonia-lyase activity
G3M63_RS16885	COG3122	Protein conserved in bacteria
G3M63_RS16890	COG4067	protein conserved in archaea
G3M63_RS16890	COG0189	ligase activity
G3M63_RS16895	COG0840	transmembrane signaling receptor activity
G3M63_RS16915	COG0418	dihydroorotase activity
G3M63_RS16925	COG2358	TRAP transporter, solute receptor (TAXI family
G3M63_RS16955	COG5265	(ABC) transporter
G3M63_RS16960	COG0659	secondary active sulfate transmembrane transporter activity
G3M63_RS16965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3M63_RS16985	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G3M63_RS17000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3M63_RS17005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3M63_RS17020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G3M63_RS17035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G3M63_RS17045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3M63_RS17090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3M63_RS17095	COG0438	transferase activity, transferring glycosyl groups
G3M63_RS17175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3M63_RS17185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3M63_RS17200	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS17205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G3M63_RS17210	COG3206	protein involved in exopolysaccharide biosynthesis
G3M63_RS17210	COG0489	protein tyrosine kinase activity
G3M63_RS17220	COG1596	polysaccharide export
G3M63_RS17235	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3M63_RS17250	COG0513	Belongs to the DEAD box helicase family
G3M63_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS17325	COG2169	Transcriptional regulator
G3M63_RS17325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G3M63_RS17330	COG3145	DNA-N1-methyladenine dioxygenase activity
G3M63_RS17335	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS17340	COG0183	Belongs to the thiolase family
G3M63_RS17365	COG3115	cell septum assembly
G3M63_RS17380	COG0471	metal ion transport
G3M63_RS17385	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS17395	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS17415	COG1138	Cytochrome C-type biogenesis protein
G3M63_RS17450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3M63_RS17460	COG0835	chemotaxis
G3M63_RS17470	COG1192	Involved in chromosome partitioning
G3M63_RS17480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G3M63_RS17490	COG0643	Histidine kinase
G3M63_RS17490	COG2198	Histidine kinase
G3M63_RS17490	COG0784	Response regulator, receiver
G3M63_RS17495	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G3M63_RS17520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G3M63_RS17530	COG2200	EAL domain
G3M63_RS17530	COG3287	FIST C domain
G3M63_RS17530	COG2199	diguanylate cyclase activity
G3M63_RS17535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3M63_RS17540	COG2124	cytochrome p450
G3M63_RS17560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G3M63_RS17560	COG2755	lipolytic protein G-D-S-L family
G3M63_RS17565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3M63_RS17575	COG3604	Transcriptional regulator
G3M63_RS17580	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
G3M63_RS17605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3M63_RS17635	COG1846	Transcriptional regulator
G3M63_RS17640	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS17645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G3M63_RS17655	COG0318	PFAM AMP-dependent synthetase and ligase
G3M63_RS17660	COG1024	Enoyl-CoA hydratase
G3M63_RS17685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G3M63_RS17705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G3M63_RS17720	COG3634	alkyl hydroperoxide reductase activity
G3M63_RS17730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3M63_RS17750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G3M63_RS17750	COG0617	tRNA 3'-terminal CCA addition
G3M63_RS17750	COG0517	IMP dehydrogenase activity
G3M63_RS17765	COG2925	Exonuclease
G3M63_RS17780	COG0589	response to stress
G3M63_RS17805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G3M63_RS17805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G3M63_RS17810	COG3706	GGDEF domain
G3M63_RS17820	COG1024	Enoyl-CoA hydratase
G3M63_RS17865	COG0583	DNA-binding transcription factor activity
G3M63_RS17890	COG0723	plastoquinol--plastocyanin reductase activity
G3M63_RS17890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3M63_RS17895	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS17915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3M63_RS17920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G3M63_RS17925	COG0585	pseudouridine synthase activity
G3M63_RS17930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G3M63_RS17940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G3M63_RS17965	COG2204	response regulator
G3M63_RS17970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3M63_RS17975	COG0577	efflux transmembrane transporter activity
G3M63_RS17975	COG1136	(ABC) transporter
G3M63_RS17995	COG2267	carboxylic ester hydrolase activity
G3M63_RS18000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G3M63_RS18005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G3M63_RS18010	COG1166	arginine decarboxylase activity
G3M63_RS18020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G3M63_RS18025	COG0662	Cupin 2, conserved barrel domain protein
G3M63_RS18030	COG5285	phytanoyl-CoA dioxygenase
G3M63_RS18035	COG0527	aspartate kinase activity
G3M63_RS18070	COG1987	bacterial-type flagellum assembly
G3M63_RS18110	COG0745	RESPONSE REGULATOR receiver
G3M63_RS18145	COG1677	Flagellar hook-basal body complex protein FliE
G3M63_RS18170	COG5002	protein histidine kinase activity
G3M63_RS18190	COG1516	flagellar protein fliS
G3M63_RS18205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G3M63_RS18230	COG0753	catalase activity
G3M63_RS18265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G3M63_RS18275	COG3639	organic phosphonate transmembrane transporter activity
G3M63_RS18320	COG2885	chlorophyll binding
G3M63_RS18355	COG3501	Rhs element vgr protein
G3M63_RS18365	COG1320	monovalent cation:proton antiporter activity
G3M63_RS18370	COG2212	antiporter activity
G3M63_RS18375	COG1863	multisubunit Na H antiporter MnhE subunit
G3M63_RS18380	COG0651	ATP synthesis coupled electron transport
G3M63_RS18385	COG1006	Multisubunit Na H antiporter MnhC subunit
G3M63_RS18390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3M63_RS18390	COG2111	Na H antiporter
G3M63_RS18395	COG1320	monovalent cation:proton antiporter activity
G3M63_RS18400	COG2212	antiporter activity
G3M63_RS18415	COG1006	Multisubunit Na H antiporter MnhC subunit
G3M63_RS18420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3M63_RS18420	COG2111	Na H antiporter
G3M63_RS18450	COG2135	peptidase activity
G3M63_RS18465	COG3547	Transposase (IS116 IS110 IS902 family)
G3M63_RS18490	COG0121	glutamine amidotransferase
G3M63_RS18500	COG2119	membrane
G3M63_RS18505	COG2813	Specifically methylates the guanine in position
G3M63_RS18510	COG1643	Atp-dependent helicase
G3M63_RS18525	COG1522	sequence-specific DNA binding
G3M63_RS18535	COG1960	acyl-CoA dehydrogenase activity
G3M63_RS18575	COG1304	FMN binding
G3M63_RS18590	COG0351	phosphomethylpyrimidine kinase
G3M63_RS18595	COG0352	thiamine-phosphate diphosphorylase activity
G3M63_RS18600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3M63_RS18625	COG1702	phosphate starvation-inducible protein PhoH
G3M63_RS18630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G3M63_RS18635	COG4535	Mg2 and Co2 transporter CorC
G3M63_RS18640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3M63_RS18650	COG0495	leucyl-tRNA aminoacylation
G3M63_RS18665	COG0589	response to stress
G3M63_RS18670	COG0659	secondary active sulfate transmembrane transporter activity
G3M63_RS18675	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G3M63_RS18690	COG2951	lytic endotransglycosylase activity
G3M63_RS18695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G3M63_RS18700	COG0321	lipoyl(octanoyl) transferase activity
G3M63_RS18705	COG2921	Belongs to the UPF0250 family
G3M63_RS18710	COG1686	Belongs to the peptidase S11 family
G3M63_RS18720	COG2951	lytic endotransglycosylase activity
G3M63_RS18725	COG0772	Belongs to the SEDS family
G3M63_RS18730	COG0768	penicillin binding
G3M63_RS18735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G3M63_RS18745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G3M63_RS18750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G3M63_RS18760	COG0586	Pfam SNARE associated Golgi protein
G3M63_RS18785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3M63_RS18790	COG0205	6-phosphofructokinase activity
G3M63_RS18840	COG4964	Belongs to the GSP D family
G3M63_RS18860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3M63_RS18865	COG0534	Mate efflux family protein
G3M63_RS18870	COG0023	Translation Initiation Factor
G3M63_RS18890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3M63_RS18905	COG2264	protein methyltransferase activity
G3M63_RS18930	COG0151	Belongs to the GarS family
G3M63_RS18935	COG5002	protein histidine kinase activity
G3M63_RS18935	COG0784	Response regulator, receiver
G3M63_RS18935	COG2205	protein histidine kinase activity
G3M63_RS18945	COG0305	Participates in initiation and elongation during chromosome replication
G3M63_RS18950	COG0359	binds to the 23S rRNA
G3M63_RS18960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G3M63_RS18975	COG0557	exoribonuclease II activity
G3M63_RS18990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G3M63_RS19000	COG0330	HflC and HflK could
G3M63_RS19005	COG0330	HflC and HflK could
G3M63_RS19010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G3M63_RS19015	COG1923	regulation of RNA biosynthetic process
G3M63_RS19020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G3M63_RS19025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G3M63_RS19030	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3M63_RS19035	COG0802	atpase or kinase
G3M63_RS19040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3M63_RS19040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G3M63_RS19055	COG1162	GTPase activity
G3M63_RS19060	COG1360	Flagellar Motor Protein
G3M63_RS19075	COG0688	phosphatidylethanolamine metabolic process
G3M63_RS19085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3M63_RS19090	COG1509	lysine 2,3-aminomutase activity
G3M63_RS19100	COG2199	diguanylate cyclase activity
G3M63_RS19130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G3M63_RS19140	COG0494	nUDIX hydrolase
G3M63_RS19150	COG1538	Outer membrane efflux protein
G3M63_RS19155	COG1519	Transferase
G3M63_RS19165	COG0667	Aldo Keto reductase
G3M63_RS19180	COG1132	(ABC) transporter
G3M63_RS19210	COG0438	transferase activity, transferring glycosyl groups
G3M63_RS19235	COG0438	transferase activity, transferring glycosyl groups
G3M63_RS19240	COG0859	PFAM glycosyl transferase family 9
G3M63_RS19315	COG0579	oxidoreductase
G3M63_RS19320	COG0501	Belongs to the peptidase M48B family
G3M63_RS19330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G3M63_RS19330	COG2755	lipolytic protein G-D-S-L family
G3M63_RS19350	COG0488	(ABC) transporter
G3M63_RS19355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G3M63_RS19375	COG2813	Specifically methylates the guanine in position