locus-tag	class	description
IH404_RS00010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IH404_RS00015	COG0427	acetyl-CoA hydrolase
IH404_RS00030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IH404_RS00040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS00055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS00065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IH404_RS00080	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS00090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IH404_RS00095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IH404_RS00100	COG0747	negative chemotaxis
IH404_RS00105	COG2003	Belongs to the UPF0758 family
IH404_RS00110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IH404_RS00115	COG0756	dUTP diphosphatase activity
IH404_RS00120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IH404_RS00125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IH404_RS00130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IH404_RS00135	COG0708	Exodeoxyribonuclease III
IH404_RS00145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IH404_RS00150	COG1561	YicC-like family, N-terminal region
IH404_RS00155	COG0194	GDP metabolic process
IH404_RS00160	COG1758	RNA polymerase activity
IH404_RS00165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IH404_RS00190	COG0848	biopolymer transport protein
IH404_RS00200	COG0583	DNA-binding transcription factor activity
IH404_RS00205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IH404_RS00235	COG1136	(ABC) transporter
IH404_RS00240	COG2815	serine threonine protein kinase
IH404_RS00240	COG0515	serine threonine protein kinase
IH404_RS00330	COG3209	COG3209 Rhs family protein
IH404_RS00360	COG3161	chorismate lyase activity
IH404_RS00365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IH404_RS00385	COG1253	flavin adenine dinucleotide binding
IH404_RS00405	COG0704	Plays a role in the regulation of phosphate uptake
IH404_RS00410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IH404_RS00415	COG0573	inorganic phosphate transmembrane transporter activity
IH404_RS00430	COG0477	Major facilitator Superfamily
IH404_RS00435	COG1607	acyl-coa hydrolase
IH404_RS00470	COG0583	DNA-binding transcription factor activity
IH404_RS00475	COG1027	Aspartate ammonia-lyase
IH404_RS00480	COG1115	amino acid carrier protein
IH404_RS00485	COG0252	asparaginase activity
IH404_RS00515	COG2808	Putative FMN-binding domain
IH404_RS00535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS00540	COG0765	amino acid transport
IH404_RS00565	COG5016	pyruvate
IH404_RS00565	COG0511	ligase activity, forming carbon-carbon bonds
IH404_RS00570	COG0439	Biotin carboxylase
IH404_RS00575	COG0583	DNA-binding transcription factor activity
IH404_RS00590	COG5001	Diguanylate cyclase
IH404_RS00590	COG3300	MHYT domain
IH404_RS00595	COG0210	DNA helicase
IH404_RS00610	COG4651	solute:proton antiporter activity
IH404_RS00610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IH404_RS00615	COG1607	acyl-coa hydrolase
IH404_RS00620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IH404_RS00630	COG0523	cobalamin synthesis protein
IH404_RS00655	COG0860	N-Acetylmuramoyl-L-alanine amidase
IH404_RS00660	COG1469	GTP cyclohydrolase I activity
IH404_RS00665	COG1121	(ABC) transporter
IH404_RS00685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IH404_RS00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IH404_RS00700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IH404_RS00710	COG3220	belongs to the UPF0276 family
IH404_RS00740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IH404_RS00745	COG2267	carboxylic ester hydrolase activity
IH404_RS00750	COG0671	phosphoesterase, PA-phosphatase related
IH404_RS00750	COG2453	phosphatase
IH404_RS00765	COG4589	Belongs to the CDS family
IH404_RS00775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IH404_RS00780	COG1349	DNA-binding transcription factor activity
IH404_RS00785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IH404_RS00790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IH404_RS00795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IH404_RS00800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IH404_RS00805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IH404_RS00810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IH404_RS00815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IH404_RS00825	COG0356	it plays a direct role in the translocation of protons across the membrane
IH404_RS00830	COG3312	ion transport
IH404_RS00835	COG1475	DNA binding
IH404_RS00840	COG1192	Involved in chromosome partitioning
IH404_RS00845	COG0357	Ribosomal RNA small subunit methyltransferase G
IH404_RS00850	COG0445	tRNA wobble uridine modification
IH404_RS00855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IH404_RS00860	COG0706	membrane insertase activity
IH404_RS00865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IH404_RS00870	COG0594	ribonuclease P activity
IH404_RS00875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IH404_RS00880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IH404_RS00885	COG0592	DNA-directed DNA polymerase activity
IH404_RS00890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IH404_RS00895	COG0187	DNA topoisomerase II activity
IH404_RS00900	COG0745	RESPONSE REGULATOR receiver
IH404_RS00905	COG2205	protein histidine kinase activity
IH404_RS00915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IH404_RS00920	COG0751	glycine-tRNA ligase activity
IH404_RS00925	COG0752	glycyl-tRNA synthetase alpha subunit
IH404_RS00930	COG2818	Glycosylase
IH404_RS00945	COG0569	domain protein
IH404_RS00950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IH404_RS00955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IH404_RS00960	COG0242	peptide deformylase activity
IH404_RS00970	COG0758	DNA mediated transformation
IH404_RS00975	COG0009	L-threonylcarbamoyladenylate synthase
IH404_RS00985	COG0408	coproporphyrinogen oxidase activity
IH404_RS00990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IH404_RS01005	COG3119	arylsulfatase activity
IH404_RS01010	COG0583	DNA-binding transcription factor activity
IH404_RS01020	COG3734	2-keto-3-deoxy-galactonokinase
IH404_RS01025	COG0800	Aldolase
IH404_RS01030	COG4948	Mandelate Racemase Muconate Lactonizing
IH404_RS01035	COG2271	Major facilitator Superfamily
IH404_RS01045	COG0159	tryptophan synthase activity
IH404_RS01065	COG3360	Dodecin
IH404_RS01075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IH404_RS01080	COG1764	response to oxidative stress
IH404_RS01105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IH404_RS01110	COG0339	signal peptide processing
IH404_RS01150	COG0659	secondary active sulfate transmembrane transporter activity
IH404_RS01160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IH404_RS01165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IH404_RS01170	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IH404_RS01185	COG3346	SURF1 family
IH404_RS01200	COG0109	protoheme IX farnesyltransferase activity
IH404_RS01215	COG2011	ABC-type metal ion transport system permease component
IH404_RS01220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IH404_RS01235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IH404_RS01240	COG1121	(ABC) transporter
IH404_RS01245	COG0735	belongs to the Fur family
IH404_RS01250	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IH404_RS01270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IH404_RS01285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IH404_RS01300	COG3023	N-Acetylmuramoyl-L-alanine amidase
IH404_RS01305	COG5002	protein histidine kinase activity
IH404_RS01310	COG2204	response regulator
IH404_RS01320	COG5487	UPF0391 membrane protein
IH404_RS01330	COG1301	dicarboxylic acid transport
IH404_RS01335	COG0700	Nucleoside recognition
IH404_RS01350	COG1127	ABC transporter
IH404_RS01355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IH404_RS01365	COG0612	Peptidase, M16
IH404_RS01370	COG1283	sodium-dependent phosphate transmembrane transporter activity
IH404_RS01375	COG0861	Integral membrane protein TerC family
IH404_RS01380	COG2851	Citrate transporter
IH404_RS01410	COG0427	acetyl-CoA hydrolase
IH404_RS01430	COG0583	DNA-binding transcription factor activity
IH404_RS01435	COG1960	acyl-CoA dehydrogenase activity
IH404_RS01475	COG0840	transmembrane signaling receptor activity
IH404_RS01505	COG5001	Diguanylate cyclase
IH404_RS01505	COG3300	MHYT domain
IH404_RS01520	COG1538	Outer membrane efflux protein
IH404_RS01525	COG2274	protein secretion by the type I secretion system
IH404_RS01530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS01535	COG2175	clavaminate synthase activity
IH404_RS01575	COG1595	DNA-templated transcription, initiation
IH404_RS01585	COG4774	siderophore transport
IH404_RS01625	COG1289	transmembrane transporter activity
IH404_RS01635	COG1566	PFAM secretion protein HlyD family protein
IH404_RS01650	COG5339	Protein conserved in bacteria
IH404_RS01655	COG0457	Tetratricopeptide repeat
IH404_RS01660	COG1649	PFAM Uncharacterised BCR, COG1649
IH404_RS01660	COG0726	polysaccharide deacetylase
IH404_RS01665	COG1215	transferase activity, transferring glycosyl groups
IH404_RS01745	COG2304	oxidoreductase activity
IH404_RS01750	COG1595	DNA-templated transcription, initiation
IH404_RS01790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IH404_RS01825	COG1715	Restriction endonuclease
IH404_RS01900	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS01905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IH404_RS01910	COG0745	RESPONSE REGULATOR receiver
IH404_RS01915	COG2199	diguanylate cyclase activity
IH404_RS01935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IH404_RS01945	COG4208	sulfate ABC transporter
IH404_RS01950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IH404_RS01965	COG2351	hydroxyisourate hydrolase activity
IH404_RS01995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IH404_RS02000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS02030	COG4771	TonB-dependent receptor
IH404_RS02035	COG2807	transmembrane transport
IH404_RS02040	COG0590	tRNA wobble adenosine to inosine editing
IH404_RS02045	COG0583	DNA-binding transcription factor activity
IH404_RS02085	COG0765	amino acid transport
IH404_RS02090	COG0765	amino acid transport
IH404_RS02095	COG1126	abc transporter atp-binding protein
IH404_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS02105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IH404_RS02120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IH404_RS02140	COG2011	ABC-type metal ion transport system permease component
IH404_RS02145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IH404_RS02175	COG1126	abc transporter atp-binding protein
IH404_RS02180	COG0765	amino acid transport
IH404_RS02185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS02190	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IH404_RS02195	COG1045	serine acetyltransferase
IH404_RS02200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IH404_RS02205	COG0667	Aldo Keto reductase
IH404_RS02210	COG2175	clavaminate synthase activity
IH404_RS02215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IH404_RS02220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IH404_RS02225	COG4521	taurine ABC transporter
IH404_RS02230	COG2918	glutathione biosynthetic process
IH404_RS02240	COG2183	response to ionizing radiation
IH404_RS02255	COG0189	ligase activity
IH404_RS02260	COG0189	ligase activity
IH404_RS02260	COG4067	protein conserved in archaea
IH404_RS02265	COG2200	EAL domain
IH404_RS02265	COG3287	FIST C domain
IH404_RS02265	COG2199	diguanylate cyclase activity
IH404_RS02270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IH404_RS02280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IH404_RS02285	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IH404_RS02310	COG2184	nucleotidyltransferase activity
IH404_RS02320	COG0514	ATP-dependent DNA helicase (RecQ)
IH404_RS02335	COG0243	molybdopterin cofactor binding
IH404_RS02345	COG1652	LysM domain
IH404_RS02350	COG1011	Hydrolase
IH404_RS02355	COG0494	nUDIX hydrolase
IH404_RS02360	COG1218	3'(2'),5'-bisphosphate nucleotidase
IH404_RS02400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IH404_RS02405	COG2957	Belongs to the agmatine deiminase family
IH404_RS02515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IH404_RS02520	COG1194	a g-specific adenine glycosylase
IH404_RS02530	COG2223	nitrite transmembrane transporter activity
IH404_RS02535	COG0131	Imidazoleglycerol-phosphate dehydratase
IH404_RS02540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IH404_RS02550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IH404_RS02555	COG0107	imidazoleglycerol-phosphate synthase activity
IH404_RS02565	COG2861	carbohydrate metabolic process
IH404_RS02570	COG0793	Belongs to the peptidase S41A family
IH404_RS02575	COG4942	peptidase
IH404_RS02580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IH404_RS02585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IH404_RS02595	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IH404_RS02615	COG3852	Histidine kinase
IH404_RS02630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IH404_RS02630	COG0301	tRNA thio-modification
IH404_RS02635	COG1217	gtp-binding protein TYPA
IH404_RS02645	COG0058	SHG alpha-glucan phosphorylase activity
IH404_RS02650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IH404_RS02665	COG0402	S-adenosylhomocysteine deaminase activity
IH404_RS02670	COG2188	Transcriptional regulator
IH404_RS02680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IH404_RS02685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IH404_RS02695	COG4176	ABC-type proline glycine betaine transport system permease component
IH404_RS02700	COG0517	IMP dehydrogenase activity
IH404_RS02700	COG4175	Glycine betaine
IH404_RS02705	COG2986	histidine ammonia-lyase
IH404_RS02710	COG2986	histidine ammonia-lyase
IH404_RS02715	COG1113	amino acid transport
IH404_RS02720	COG1228	amidohydrolase
IH404_RS02735	COG0657	acetylesterase activity
IH404_RS02740	COG0596	Alpha beta hydrolase
IH404_RS02745	COG1490	D-aminoacyl-tRNA deacylase activity
IH404_RS02750	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IH404_RS02755	COG2943	transferase activity, transferring hexosyl groups
IH404_RS02760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS02770	COG0765	amino acid transport
IH404_RS02775	COG1126	abc transporter atp-binding protein
IH404_RS02780	COG0840	transmembrane signaling receptor activity
IH404_RS02785	COG0840	transmembrane signaling receptor activity
IH404_RS02800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IH404_RS02805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IH404_RS02810	COG0140	phosphoribosyl-ATP diphosphatase activity
IH404_RS02815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IH404_RS02820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IH404_RS02830	COG2226	methyltransferase
IH404_RS02875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IH404_RS02880	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IH404_RS02890	COG0018	arginyl-trna synthetase
IH404_RS02895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IH404_RS02900	COG0254	rRNA binding
IH404_RS02910	COG0281	malic enzyme
IH404_RS02940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IH404_RS02945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IH404_RS02955	COG0069	glutamate synthase activity
IH404_RS02955	COG0070	glutamate synthase
IH404_RS02955	COG0067	glutamate synthase
IH404_RS02960	COG0493	'glutamate synthase
IH404_RS02965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IH404_RS02970	COG2814	Major facilitator Superfamily
IH404_RS02975	COG0583	DNA-binding transcription factor activity
IH404_RS02985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IH404_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS03000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IH404_RS03010	COG2226	methyltransferase
IH404_RS03050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IH404_RS03060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IH404_RS03065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IH404_RS03080	COG1192	Involved in chromosome partitioning
IH404_RS03090	COG3118	belongs to the thioredoxin family
IH404_RS03100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IH404_RS03105	COG3264	Mechanosensitive ion channel
IH404_RS03105	COG1196	nuclear chromosome segregation
IH404_RS03110	COG3263	regulation of cellular component size
IH404_RS03130	COG1960	acyl-CoA dehydrogenase activity
IH404_RS03135	COG0506	proline dehydrogenase activity
IH404_RS03135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IH404_RS03135	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IH404_RS03140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IH404_RS03155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IH404_RS03160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IH404_RS03180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IH404_RS03185	COG0859	PFAM glycosyl transferase family 9
IH404_RS03190	COG0859	PFAM glycosyl transferase family 9
IH404_RS03195	COG0438	transferase activity, transferring glycosyl groups
IH404_RS03215	COG0515	serine threonine protein kinase
IH404_RS03220	COG4772	TonB-dependent receptor
IH404_RS03230	COG2192	nodulation
IH404_RS03245	COG0438	transferase activity, transferring glycosyl groups
IH404_RS03250	COG1215	transferase activity, transferring glycosyl groups
IH404_RS03260	COG1132	(ABC) transporter
IH404_RS03265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IH404_RS03265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IH404_RS03270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IH404_RS03280	COG0667	Aldo Keto reductase
IH404_RS03300	COG1519	Transferase
IH404_RS03305	COG1538	Outer membrane efflux protein
IH404_RS03310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IH404_RS03325	COG0494	nUDIX hydrolase
IH404_RS03335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IH404_RS03340	COG3150	esterase
IH404_RS03370	COG0560	Phosphoserine phosphatase
IH404_RS03370	COG3830	Belongs to the UPF0237 family
IH404_RS03375	COG0688	phosphatidylethanolamine metabolic process
IH404_RS03405	COG1162	GTPase activity
IH404_RS03410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IH404_RS03415	COG2860	membrane
IH404_RS03425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IH404_RS03425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IH404_RS03430	COG0802	atpase or kinase
IH404_RS03435	COG0860	N-Acetylmuramoyl-L-alanine amidase
IH404_RS03440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IH404_RS03445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IH404_RS03450	COG1923	regulation of RNA biosynthetic process
IH404_RS03455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IH404_RS03460	COG0330	HflC and HflK could
IH404_RS03465	COG0330	HflC and HflK could
IH404_RS03470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IH404_RS03475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IH404_RS03485	COG1178	ABC-type Fe3 transport system permease component
IH404_RS03490	COG1840	ABC-type Fe3 transport system, periplasmic component
IH404_RS03505	COG0557	exoribonuclease II activity
IH404_RS03510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IH404_RS03515	COG0360	Binds together with S18 to 16S ribosomal RNA
IH404_RS03520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IH404_RS03530	COG0359	binds to the 23S rRNA
IH404_RS03535	COG0305	Participates in initiation and elongation during chromosome replication
IH404_RS03545	COG1032	radical SAM domain protein
IH404_RS03565	COG2307	Protein conserved in bacteria
IH404_RS03565	COG2308	Evidence 4 Homologs of previously reported genes of
IH404_RS03585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IH404_RS03590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IH404_RS03595	COG0583	DNA-binding transcription factor activity
IH404_RS03600	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS03605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS03635	COG4221	oxidoreductase activity
IH404_RS03655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IH404_RS03660	COG0830	nickel cation binding
IH404_RS03665	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IH404_RS03670	COG0791	NLP P60 protein
IH404_RS03675	COG1309	transcriptional regulator
IH404_RS03685	COG2982	Protein involved in outer membrane biogenesis
IH404_RS03695	COG0697	spore germination
IH404_RS03715	COG0443	Heat shock 70 kDa protein
IH404_RS03720	COG0484	heat shock protein binding
IH404_RS03730	COG0804	urea catabolic process
IH404_RS03735	COG0832	Belongs to the urease beta subunit family
IH404_RS03750	COG0831	urea catabolic process
IH404_RS03755	COG0829	nickel cation binding
IH404_RS03765	COG0411	ABC transporter
IH404_RS03780	COG0683	leucine binding
IH404_RS03805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IH404_RS03815	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IH404_RS03850	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IH404_RS03855	COG3657	addiction module killer protein
IH404_RS03870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IH404_RS03895	COG2095	MarC family integral membrane protein
IH404_RS03905	COG0151	Belongs to the GarS family
IH404_RS03910	COG0138	bifunctional purine biosynthesis protein purh
IH404_RS03920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IH404_RS03930	COG2264	protein methyltransferase activity
IH404_RS03945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IH404_RS03970	COG0023	Translation Initiation Factor
IH404_RS03975	COG1166	arginine decarboxylase activity
IH404_RS03980	COG0534	Mate efflux family protein
IH404_RS03985	COG2373	Large extracellular alpha-helical protein
IH404_RS03995	COG4953	penicillin-binding protein 1C
IH404_RS04005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IH404_RS04075	COG4964	Belongs to the GSP D family
IH404_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS04130	COG2217	Heavy metal translocating P-type atpase
IH404_RS04145	COG2814	Major facilitator Superfamily
IH404_RS04155	COG0604	alcohol dehydrogenase
IH404_RS04160	COG0583	DNA-binding transcription factor activity
IH404_RS04170	COG0477	Major facilitator Superfamily
IH404_RS04175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IH404_RS04180	COG0387	Pfam Sodium calcium exchanger
IH404_RS04195	COG1739	Uncharacterized protein family UPF0029
IH404_RS04200	COG1309	transcriptional regulator
IH404_RS04205	COG2233	PERMEase
IH404_RS04250	COG2995	paraquat-inducible protein a
IH404_RS04255	COG2995	paraquat-inducible protein a
IH404_RS04260	COG3008	intermembrane lipid transfer
IH404_RS04285	COG0456	acetyltransferase
IH404_RS04295	COG0288	reversible hydration of carbon dioxide
IH404_RS04315	COG2031	fatty acid transporter
IH404_RS04390	COG1181	Belongs to the D-alanine--D-alanine ligase family
IH404_RS04400	COG0405	Gamma-glutamyltransferase
IH404_RS04460	COG4794	Type iii secretion
IH404_RS04470	COG4792	protein secretion
IH404_RS04530	COG0193	aminoacyl-tRNA hydrolase activity
IH404_RS04535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IH404_RS04540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IH404_RS04550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IH404_RS04555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IH404_RS04565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IH404_RS04570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IH404_RS04585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IH404_RS04605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IH404_RS04615	COG0493	'glutamate synthase
IH404_RS04620	COG4221	oxidoreductase activity
IH404_RS04630	COG0415	Belongs to the DNA photolyase family
IH404_RS04635	COG0789	Transcriptional regulator
IH404_RS04650	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IH404_RS04655	COG1090	epimerase
IH404_RS04660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IH404_RS04670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IH404_RS04680	COG0175	sulfate reduction
IH404_RS04690	COG0204	Acyl-transferase
IH404_RS04695	COG0280	phosphate acetyltransferase
IH404_RS04695	COG0857	belongs to the CobB CobQ family
IH404_RS04710	COG0268	Binds directly to 16S ribosomal RNA
IH404_RS04720	COG0196	riboflavin kinase activity
IH404_RS04725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IH404_RS04730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IH404_RS04735	COG1047	Peptidyl-prolyl cis-trans
IH404_RS04740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IH404_RS04770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS04795	COG0542	response to heat
IH404_RS04820	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IH404_RS04880	COG5002	protein histidine kinase activity
IH404_RS04885	COG2433	Pfam Transposase IS66
IH404_RS04905	COG3121	Chaperone
IH404_RS04955	COG2197	response regulator
IH404_RS04960	COG2205	protein histidine kinase activity
IH404_RS04960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS04965	COG1716	ATPase activity
IH404_RS04965	COG5001	Diguanylate cyclase
IH404_RS05185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IH404_RS05195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IH404_RS05245	COG3081	Nucleoid-associated protein
IH404_RS05255	COG0305	Participates in initiation and elongation during chromosome replication
IH404_RS05280	COG2894	cell division
IH404_RS05290	COG1252	NADH dehydrogenase
IH404_RS05315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IH404_RS05320	COG0237	dephospho-CoA kinase activity
IH404_RS05360	COG3023	N-Acetylmuramoyl-L-alanine amidase
IH404_RS05370	COG0840	transmembrane signaling receptor activity
IH404_RS05380	COG0084	hydrolase, TatD family'
IH404_RS05385	COG1609	Transcriptional regulator
IH404_RS05395	COG1105	Belongs to the carbohydrate kinase PfkB family
IH404_RS05400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IH404_RS05400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IH404_RS05400	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IH404_RS05410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IH404_RS05415	COG4774	siderophore transport
IH404_RS05420	COG3128	pkhd-type hydroxylase
IH404_RS05430	COG0019	diaminopimelate decarboxylase activity
IH404_RS05455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IH404_RS05480	COG4608	Belongs to the ABC transporter superfamily
IH404_RS05485	COG0444	Belongs to the ABC transporter superfamily
IH404_RS05490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IH404_RS05495	COG0601	transmembrane transport
IH404_RS05500	COG0747	negative chemotaxis
IH404_RS05510	COG0747	negative chemotaxis
IH404_RS05515	COG0747	negative chemotaxis
IH404_RS05520	COG0747	negative chemotaxis
IH404_RS05540	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IH404_RS05560	COG0180	Tryptophanyl-tRNA synthetase
IH404_RS05565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IH404_RS05575	COG1960	acyl-CoA dehydrogenase activity
IH404_RS05580	COG0667	Aldo Keto reductase
IH404_RS05585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IH404_RS05590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IH404_RS05595	COG0723	plastoquinol--plastocyanin reductase activity
IH404_RS05600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IH404_RS05605	COG2857	Cytochrome c1
IH404_RS05610	COG0625	glutathione transferase activity
IH404_RS05615	COG2969	positive regulation of protein catabolic process
IH404_RS05620	COG2186	Transcriptional regulator
IH404_RS05630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IH404_RS05640	COG2271	Major facilitator Superfamily
IH404_RS05645	COG2721	sulfolactate sulfo-lyase activity
IH404_RS05655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IH404_RS05665	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IH404_RS05670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IH404_RS05675	COG0154	amidase activity
IH404_RS05680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IH404_RS05685	COG1077	Cell shape determining protein MreB Mrl
IH404_RS05690	COG1792	Involved in formation and maintenance of cell shape
IH404_RS05700	COG0424	maF-like protein
IH404_RS05705	COG1530	ribonuclease E activity
IH404_RS05715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IH404_RS05720	COG0312	modulator of DNA gyrase
IH404_RS05725	COG3028	Belongs to the UPF0307 family
IH404_RS05730	COG0312	modulator of DNA gyrase
IH404_RS05765	COG1660	Displays ATPase and GTPase activities
IH404_RS05780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IH404_RS05785	COG1137	ATPase activity
IH404_RS05790	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IH404_RS05800	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IH404_RS05810	COG1127	ABC transporter
IH404_RS05815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IH404_RS05820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IH404_RS05840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IH404_RS05845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IH404_RS05850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IH404_RS05855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IH404_RS05865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IH404_RS05925	COG2135	peptidase activity
IH404_RS05930	COG0501	Belongs to the peptidase M48B family
IH404_RS05935	COG2119	membrane
IH404_RS05940	COG2813	Specifically methylates the guanine in position
IH404_RS05945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IH404_RS05950	COG1280	lysine exporter protein (LysE YggA)
IH404_RS05955	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS05980	COG3008	intermembrane lipid transfer
IH404_RS05985	COG2995	paraquat-inducible protein a
IH404_RS05995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IH404_RS06000	COG2885	chlorophyll binding
IH404_RS06005	COG2823	Periplasmic or secreted lipoprotein
IH404_RS06010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IH404_RS06015	COG0792	nuclease activity
IH404_RS06035	COG2001	Belongs to the MraZ family
IH404_RS06040	COG0275	rRNA processing
IH404_RS06055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IH404_RS06060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IH404_RS06065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IH404_RS06070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IH404_RS06075	COG0772	Belongs to the SEDS family
IH404_RS06080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IH404_RS06085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IH404_RS06090	COG1181	Belongs to the D-alanine--D-alanine ligase family
IH404_RS06105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IH404_RS06110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IH404_RS06115	COG2203	Gaf domain
IH404_RS06115	COG3706	GGDEF domain
IH404_RS06115	COG4251	negative regulation of phosphorylation
IH404_RS06115	COG5001	Diguanylate cyclase
IH404_RS06125	COG5002	protein histidine kinase activity
IH404_RS06150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS06165	COG0835	chemotaxis
IH404_RS06165	COG0784	Response regulator, receiver
IH404_RS06170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IH404_RS06175	COG0583	DNA-binding transcription factor activity
IH404_RS06195	COG1566	PFAM secretion protein HlyD family protein
IH404_RS06205	COG0477	Major facilitator Superfamily
IH404_RS06225	COG0300	oxidoreductase activity
IH404_RS06240	COG0662	Cupin 2, conserved barrel domain protein
IH404_RS06240	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IH404_RS06255	COG1696	Membrane protein involved in D-alanine export
IH404_RS06270	COG3420	alginic acid biosynthetic process
IH404_RS06280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IH404_RS06285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS06290	COG1215	transferase activity, transferring glycosyl groups
IH404_RS06300	COG3022	response to hydroperoxide
IH404_RS06310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IH404_RS06320	COG0315	cyclic pyranopterin monophosphate synthase activity
IH404_RS06325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IH404_RS06345	COG0513	Belongs to the DEAD box helicase family
IH404_RS06350	COG0400	carboxylic ester hydrolase activity
IH404_RS06355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS06360	COG4597	amino acid ABC transporter
IH404_RS06365	COG0765	amino acid transport
IH404_RS06370	COG1126	abc transporter atp-binding protein
IH404_RS06380	COG2807	transmembrane transport
IH404_RS06395	COG3188	usher protein
IH404_RS06400	COG3121	Chaperone
IH404_RS06430	COG2205	protein histidine kinase activity
IH404_RS06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS06445	COG2827	Endonuclease containing a URI domain
IH404_RS06450	COG4774	siderophore transport
IH404_RS06455	COG2027	D-alanyl-D-alanine carboxypeptidase
IH404_RS06465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IH404_RS06470	COG0179	Fumarylacetoacetate (FAA) hydrolase
IH404_RS06490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IH404_RS06515	COG1760	l-serine dehydratase
IH404_RS06520	COG0583	DNA-binding transcription factor activity
IH404_RS06530	COG0477	Major facilitator Superfamily
IH404_RS06535	COG0583	DNA-binding transcription factor activity
IH404_RS06540	COG4772	TonB-dependent receptor
IH404_RS06545	COG3712	iron ion homeostasis
IH404_RS06550	COG1595	DNA-templated transcription, initiation
IH404_RS06575	COG3712	iron ion homeostasis
IH404_RS06585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IH404_RS06590	COG3081	Nucleoid-associated protein
IH404_RS06600	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IH404_RS06605	COG0525	valine-tRNA ligase activity
IH404_RS06620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IH404_RS06625	COG0795	lipopolysaccharide-transporting ATPase activity
IH404_RS06630	COG0795	lipopolysaccharide-transporting ATPase activity
IH404_RS06635	COG0481	GTPase activity
IH404_RS06640	COG0681	Belongs to the peptidase S26 family
IH404_RS06645	COG0571	ribonuclease III activity
IH404_RS06650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IH404_RS06655	COG1381	Involved in DNA repair and RecF pathway recombination
IH404_RS06660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IH404_RS06670	COG0590	tRNA wobble adenosine to inosine editing
IH404_RS06675	COG0500	methyltransferase
IH404_RS06680	COG2226	methyltransferase
IH404_RS06695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IH404_RS06725	COG4206	TonB-dependent receptor
IH404_RS06730	COG4628	conserved protein (DUF2132)
IH404_RS06740	COG2375	cellular response to nickel ion
IH404_RS06745	COG1695	Transcriptional regulator
IH404_RS06830	COG1113	amino acid transport
IH404_RS06835	COG0339	signal peptide processing
IH404_RS06860	COG0069	glutamate synthase activity
IH404_RS06865	COG0254	rRNA binding
IH404_RS06875	COG3290	protein histidine kinase activity
IH404_RS06880	COG1858	cytochrome C peroxidase
IH404_RS06895	COG0494	nUDIX hydrolase
IH404_RS06905	COG0583	DNA-binding transcription factor activity
IH404_RS06915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IH404_RS06935	COG2076	Multidrug Resistance protein
IH404_RS06950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IH404_RS06965	COG4191	Histidine kinase
IH404_RS06970	COG2204	response regulator
IH404_RS06990	COG1126	abc transporter atp-binding protein
IH404_RS06995	COG0765	amino acid transport
IH404_RS07000	COG0765	amino acid transport
IH404_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS07020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IH404_RS07030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IH404_RS07035	COG3842	ATPase activity
IH404_RS07040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IH404_RS07045	COG0243	molybdopterin cofactor binding
IH404_RS07050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IH404_RS07065	COG0450	alkyl hydroperoxide reductase
IH404_RS07070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IH404_RS07075	COG0418	dihydroorotase activity
IH404_RS07085	COG0137	argininosuccinate synthase activity
IH404_RS07090	COG2197	response regulator
IH404_RS07100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IH404_RS07105	COG2878	Part of a membrane complex involved in electron transport
IH404_RS07110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IH404_RS07110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IH404_RS07115	COG0489	protein tyrosine kinase activity
IH404_RS07120	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IH404_RS07125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IH404_RS07320	COG3179	chitinase
IH404_RS07330	COG1546	Belongs to the CinA family
IH404_RS07335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IH404_RS07340	COG2137	regulation of response to DNA damage stimulus
IH404_RS07355	COG3148	PFAM DTW domain containing protein
IH404_RS07370	COG0583	DNA-binding transcription factor activity
IH404_RS07385	COG4807	Protein conserved in bacteria
IH404_RS07400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IH404_RS07405	COG3158	transport of potassium into the cell
IH404_RS07410	COG1902	pentaerythritol trinitrate reductase activity
IH404_RS07420	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IH404_RS07440	COG0457	Tetratricopeptide repeat
IH404_RS07440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IH404_RS07455	COG2201	protein-glutamate methylesterase activity
IH404_RS07460	COG2203	Gaf domain
IH404_RS07460	COG3706	GGDEF domain
IH404_RS07460	COG4251	negative regulation of phosphorylation
IH404_RS07460	COG5001	Diguanylate cyclase
IH404_RS07490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IH404_RS07505	COG1073	alpha beta
IH404_RS07520	COG2885	chlorophyll binding
IH404_RS07535	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IH404_RS07540	COG0563	adenylate kinase activity
IH404_RS07545	COG1214	PFAM Peptidase M22, glycoprotease
IH404_RS07555	COG1801	Protein of unknown function DUF72
IH404_RS07570	COG0742	ribosomal rna small subunit methyltransferase
IH404_RS07580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS07600	COG2937	Belongs to the GPAT DAPAT family
IH404_RS07615	COG2226	methyltransferase
IH404_RS07620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IH404_RS07625	COG1215	transferase activity, transferring glycosyl groups
IH404_RS07630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IH404_RS07635	COG2166	iron-sulfur cluster assembly
IH404_RS07640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IH404_RS07645	COG2171	N-acyltransferase activity
IH404_RS07650	COG1393	Belongs to the ArsC family
IH404_RS07655	COG0025	NhaP-type Na H and K H
IH404_RS07660	COG0436	Aminotransferase
IH404_RS07665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IH404_RS07675	COG0052	Belongs to the universal ribosomal protein uS2 family
IH404_RS07680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IH404_RS07685	COG0528	UMP kinase activity
IH404_RS07690	COG0233	cytoplasmic translational termination
IH404_RS07695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IH404_RS07705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IH404_RS07715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IH404_RS07725	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IH404_RS07730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IH404_RS07735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IH404_RS07740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IH404_RS07745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IH404_RS07750	COG0587	DNA-directed DNA polymerase activity
IH404_RS07755	COG0825	malonyl-CoA metabolic process
IH404_RS07760	COG0037	tRNA processing
IH404_RS07765	COG0504	CTP synthase activity
IH404_RS07770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IH404_RS07775	COG0148	phosphopyruvate hydratase activity
IH404_RS07785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IH404_RS07800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IH404_RS07805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IH404_RS07810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IH404_RS07815	COG0585	pseudouridine synthase activity
IH404_RS07820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IH404_RS07825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IH404_RS07840	COG1278	Cold shock
IH404_RS07845	COG0717	Belongs to the dCTP deaminase family
IH404_RS07860	COG1201	RNA secondary structure unwinding
IH404_RS07890	COG1793	dna ligase
IH404_RS07900	COG2366	antibiotic biosynthetic process
IH404_RS07905	COG0653	protein targeting
IH404_RS07915	COG3012	SEC-C Motif Domain Protein
IH404_RS07925	COG0010	Belongs to the arginase family
IH404_RS07950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IH404_RS07955	COG1760	l-serine dehydratase
IH404_RS07960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IH404_RS07970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IH404_RS07975	COG0583	DNA-binding transcription factor activity
IH404_RS07985	COG5295	Hep Hag repeat protein
IH404_RS08035	COG1061	Type III restriction enzyme res subunit
IH404_RS08060	COG5642	Protein of unknown function (DUF2384)
IH404_RS08100	COG1199	ATP-dependent helicase activity
IH404_RS08120	COG0259	pyridoxamine-phosphate oxidase activity
IH404_RS08130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IH404_RS08140	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IH404_RS08160	COG0583	DNA-binding transcription factor activity
IH404_RS08175	COG3220	belongs to the UPF0276 family
IH404_RS08230	COG2271	Major facilitator Superfamily
IH404_RS08235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IH404_RS08255	COG0583	DNA-binding transcription factor activity
IH404_RS08265	COG0306	phosphate transporter
IH404_RS08275	COG1414	Transcriptional regulator
IH404_RS08280	COG2814	Major facilitator Superfamily
IH404_RS08285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IH404_RS08290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IH404_RS08295	COG0183	Belongs to the thiolase family
IH404_RS08300	COG3485	protocatechuate 3,4-dioxygenase
IH404_RS08305	COG3485	protocatechuate 3,4-dioxygenase
IH404_RS08310	COG0477	Major facilitator Superfamily
IH404_RS08320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IH404_RS08325	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IH404_RS08355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS08360	COG1309	transcriptional regulator
IH404_RS08365	COG1902	pentaerythritol trinitrate reductase activity
IH404_RS08370	COG2814	Major facilitator Superfamily
IH404_RS08410	COG1473	amidohydrolase
IH404_RS08420	COG0154	amidase activity
IH404_RS08435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IH404_RS08465	COG1629	transport
IH404_RS08480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IH404_RS08485	COG0235	Class ii aldolase
IH404_RS08490	COG1396	sequence-specific DNA binding
IH404_RS08500	COG1454	alcohol dehydrogenase
IH404_RS08540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IH404_RS08555	COG0583	DNA-binding transcription factor activity
IH404_RS08560	COG2814	Major facilitator Superfamily
IH404_RS08570	COG2267	carboxylic ester hydrolase activity
IH404_RS08600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IH404_RS08675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IH404_RS08705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IH404_RS08715	COG0425	Belongs to the sulfur carrier protein TusA family
IH404_RS08720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IH404_RS08730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IH404_RS08735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IH404_RS08740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IH404_RS08745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IH404_RS08790	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
IH404_RS08795	COG0583	DNA-binding transcription factor activity
IH404_RS08800	COG0477	Major facilitator Superfamily
IH404_RS08825	COG0583	DNA-binding transcription factor activity
IH404_RS08865	COG2807	transmembrane transport
IH404_RS08875	COG0583	DNA-binding transcription factor activity
IH404_RS08880	COG2910	NAD(P)H-binding
IH404_RS08890	COG0583	DNA-binding transcription factor activity
IH404_RS08925	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IH404_RS08935	COG0583	DNA-binding transcription factor activity
IH404_RS08945	COG0174	glutamine synthetase
IH404_RS08960	COG3100	YcgL domain-containing protein
IH404_RS08965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IH404_RS08980	COG2983	Belongs to the UPF0260 family
IH404_RS09020	COG1770	oligopeptidase
IH404_RS09030	COG0121	glutamine amidotransferase
IH404_RS09040	COG0583	DNA-binding transcription factor activity
IH404_RS09045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IH404_RS09050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IH404_RS09055	COG1984	allophanate hydrolase subunit 2
IH404_RS09065	COG0542	response to heat
IH404_RS09075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IH404_RS09090	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IH404_RS09095	COG0425	Belongs to the sulfur carrier protein TusA family
IH404_RS09105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IH404_RS09115	COG1132	(ABC) transporter
IH404_RS09120	COG0741	lytic transglycosylase activity
IH404_RS09125	COG0488	(ABC) transporter
IH404_RS09130	COG0589	response to stress
IH404_RS09140	COG1250	3-hydroxyacyl-CoA dehydrogenase
IH404_RS09140	COG1024	Enoyl-CoA hydratase
IH404_RS09145	COG0183	Belongs to the thiolase family
IH404_RS09190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IH404_RS09200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IH404_RS09210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IH404_RS09215	COG0584	glycerophosphoryl diester phosphodiesterase
IH404_RS09225	COG4591	ABC-type transport system involved in lipoprotein release permease component
IH404_RS09230	COG1136	(ABC) transporter
IH404_RS09235	COG4591	ABC-type transport system involved in lipoprotein release permease component
IH404_RS09255	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IH404_RS09255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IH404_RS09270	COG2853	Lipoprotein
IH404_RS09275	COG2204	response regulator
IH404_RS09285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IH404_RS09290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IH404_RS09310	COG1192	Involved in chromosome partitioning
IH404_RS09320	COG2814	Major facilitator Superfamily
IH404_RS09325	COG0579	oxidoreductase
IH404_RS09330	COG0583	DNA-binding transcription factor activity
IH404_RS09355	COG1611	Belongs to the LOG family
IH404_RS09365	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IH404_RS09380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IH404_RS09385	COG0583	DNA-binding transcription factor activity
IH404_RS09390	COG2814	Major facilitator Superfamily
IH404_RS09400	COG2233	PERMEase
IH404_RS09405	COG2267	carboxylic ester hydrolase activity
IH404_RS09410	COG2197	response regulator
IH404_RS09415	COG0596	Alpha beta hydrolase
IH404_RS09425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IH404_RS09430	COG0444	Belongs to the ABC transporter superfamily
IH404_RS09435	COG4608	Belongs to the ABC transporter superfamily
IH404_RS09440	COG0747	negative chemotaxis
IH404_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS09450	COG0546	phosphoglycolate phosphatase activity
IH404_RS09455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IH404_RS09460	COG0402	S-adenosylhomocysteine deaminase activity
IH404_RS09465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IH404_RS09475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IH404_RS09485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IH404_RS09490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IH404_RS09495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IH404_RS09510	COG0776	regulation of translation
IH404_RS09535	COG1442	glycosyl transferase family 8
IH404_RS09535	COG1216	Glycosyl transferase, family 2
IH404_RS09540	COG0438	transferase activity, transferring glycosyl groups
IH404_RS09545	COG0438	transferase activity, transferring glycosyl groups
IH404_RS09570	COG1555	photosystem II stabilization
IH404_RS09600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IH404_RS09610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IH404_RS09615	COG2205	protein histidine kinase activity
IH404_RS09620	COG0745	RESPONSE REGULATOR receiver
IH404_RS09665	COG3209	COG3209 Rhs family protein
IH404_RS09675	COG0084	hydrolase, TatD family'
IH404_RS09680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IH404_RS09705	COG1131	(ABC) transporter
IH404_RS09715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IH404_RS09720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IH404_RS09725	COG4181	ATPase activity
IH404_RS09740	COG1376	ErfK ybiS ycfS ynhG family protein
IH404_RS09770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IH404_RS09790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IH404_RS09805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IH404_RS09810	COG1764	response to oxidative stress
IH404_RS09815	COG1846	Transcriptional regulator
IH404_RS09820	COG0583	DNA-binding transcription factor activity
IH404_RS09825	COG0730	response to heat
IH404_RS09830	COG0583	DNA-binding transcription factor activity
IH404_RS09840	COG3214	Protein conserved in bacteria
IH404_RS09845	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IH404_RS09865	COG3384	dioxygenase
IH404_RS09870	COG0500	methyltransferase
IH404_RS09875	COG0501	Belongs to the peptidase M48B family
IH404_RS09880	COG0436	Aminotransferase
IH404_RS09885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IH404_RS09890	COG0386	Belongs to the glutathione peroxidase family
IH404_RS09895	COG2205	protein histidine kinase activity
IH404_RS09895	COG5002	protein histidine kinase activity
IH404_RS09895	COG0784	Response regulator, receiver
IH404_RS09905	COG1956	GAF domain-containing protein
IH404_RS09910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS09910	COG2205	protein histidine kinase activity
IH404_RS09915	COG2197	response regulator
IH404_RS09945	COG0004	ammonium transporteR
IH404_RS09965	COG0564	pseudouridine synthase activity
IH404_RS09975	COG0746	molybdenum cofactor guanylyltransferase activity
IH404_RS09980	COG0521	Mo-molybdopterin cofactor biosynthetic process
IH404_RS09985	COG0303	'Molybdopterin
IH404_RS09990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IH404_RS10000	COG4133	protoheme IX ABC transporter activity
IH404_RS10020	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IH404_RS10025	COG1138	Cytochrome C-type biogenesis protein
IH404_RS10035	COG3088	subunit of a heme lyase
IH404_RS10040	COG4235	cytochrome complex assembly
IH404_RS10050	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IH404_RS10055	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IH404_RS10065	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IH404_RS10075	COG2814	Major facilitator Superfamily
IH404_RS10085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IH404_RS10095	COG0469	pyruvate kinase activity
IH404_RS10105	COG2084	Dehydrogenase
IH404_RS10110	COG3622	Belongs to the hyi family
IH404_RS10115	COG3960	tartronate-semialdehyde synthase activity
IH404_RS10130	COG1309	transcriptional regulator
IH404_RS10135	COG2354	Protein conserved in bacteria
IH404_RS10140	COG2853	Lipoprotein
IH404_RS10160	COG2113	Glycine betaine
IH404_RS10165	COG3162	membrane
IH404_RS10170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IH404_RS10180	COG2009	succinate dehydrogenase
IH404_RS10185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IH404_RS10190	COG1053	succinate dehydrogenase
IH404_RS10195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IH404_RS10210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IH404_RS10215	COG0045	succinate-CoA ligase (ADP-forming) activity
IH404_RS10250	COG0326	Molecular chaperone. Has ATPase activity
IH404_RS10260	COG1741	Belongs to the pirin family
IH404_RS10285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IH404_RS10290	COG5002	protein histidine kinase activity
IH404_RS10290	COG2205	protein histidine kinase activity
IH404_RS10290	COG0784	Response regulator, receiver
IH404_RS10305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IH404_RS10320	COG1022	Amp-dependent synthetase and ligase
IH404_RS10335	COG2267	carboxylic ester hydrolase activity
IH404_RS10345	COG0628	permease
IH404_RS10350	COG2205	protein histidine kinase activity
IH404_RS10360	COG0284	orotidine-5'-phosphate decarboxylase activity
IH404_RS10365	COG2130	NADP-dependent
IH404_RS10380	COG0840	transmembrane signaling receptor activity
IH404_RS10415	COG2197	response regulator
IH404_RS10440	COG3217	Mosc domain protein beta barrel domain protein
IH404_RS10440	COG0633	Ferredoxin
IH404_RS10455	COG0811	peptide transport
IH404_RS10480	COG3540	Alkaline phosphatase
IH404_RS10510	COG0625	glutathione transferase activity
IH404_RS10515	COG1131	(ABC) transporter
IH404_RS10520	COG0842	Transport permease protein
IH404_RS10545	COG2076	Multidrug Resistance protein
IH404_RS10550	COG0385	Bile acid
IH404_RS10555	COG2974	May be involved in recombination
IH404_RS10585	COG2010	Cytochrome c
IH404_RS10590	COG0545	Peptidyl-prolyl cis-trans isomerase
IH404_RS10625	COG3842	ATPase activity
IH404_RS10635	COG1176	ABC-type spermidine putrescine transport system, permease component I
IH404_RS10660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IH404_RS10665	COG1121	(ABC) transporter
IH404_RS10695	COG1509	lysine 2,3-aminomutase activity
IH404_RS10730	COG3829	transcription factor binding
IH404_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS10765	COG5006	permease, DMT superfamily
IH404_RS10795	COG0768	penicillin binding
IH404_RS10815	COG0417	DNA replication proofreading
IH404_RS10830	COG0728	peptidoglycan biosynthetic process
IH404_RS10895	COG3712	iron ion homeostasis
IH404_RS10900	COG1595	DNA-templated transcription, initiation
IH404_RS10915	COG4977	sequence-specific DNA binding
IH404_RS10925	COG3387	PFAM Glycoside hydrolase 15-related
IH404_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS10950	COG4772	TonB-dependent receptor
IH404_RS10970	COG2223	nitrite transmembrane transporter activity
IH404_RS10990	COG3675	Pfam Lipase (class 3)
IH404_RS10995	COG0402	S-adenosylhomocysteine deaminase activity
IH404_RS11000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IH404_RS11005	COG1051	belongs to the nudix hydrolase family
IH404_RS11010	COG0720	synthase
IH404_RS11040	COG0840	transmembrane signaling receptor activity
IH404_RS11045	COG2056	Na+-H+ antiporter family
IH404_RS11055	COG0826	peptidase U32
IH404_RS11060	COG0628	permease
IH404_RS11080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IH404_RS11085	COG3132	Protein of unknown function, DUF480
IH404_RS11100	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IH404_RS11110	COG0583	DNA-binding transcription factor activity
IH404_RS11120	COG1253	flavin adenine dinucleotide binding
IH404_RS11125	COG0709	Synthesizes selenophosphate from selenide and ATP
IH404_RS11130	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IH404_RS11135	COG0701	Predicted permease
IH404_RS11145	COG0625	glutathione transferase activity
IH404_RS11150	COG0384	phenazine biosynthesis protein PhzF
IH404_RS11155	COG0113	porphobilinogen synthase activity
IH404_RS11165	COG3209	COG3209 Rhs family protein
IH404_RS11195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IH404_RS11200	COG0583	DNA-binding transcription factor activity
IH404_RS11210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IH404_RS11215	COG0517	IMP dehydrogenase activity
IH404_RS11220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IH404_RS11245	COG0174	glutamine synthetase
IH404_RS11260	COG2814	Major facilitator Superfamily
IH404_RS11290	COG0640	Transcriptional regulator
IH404_RS11295	COG2124	cytochrome p450
IH404_RS11305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IH404_RS11315	COG2197	response regulator
IH404_RS11320	COG2205	protein histidine kinase activity
IH404_RS11320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS11330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IH404_RS11335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IH404_RS11355	COG2197	response regulator
IH404_RS11360	COG0322	excinuclease ABC activity
IH404_RS11375	COG2197	response regulator
IH404_RS11385	COG3121	Chaperone
IH404_RS11390	COG3188	usher protein
IH404_RS11395	COG3121	Chaperone
IH404_RS11475	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IH404_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS11510	COG3121	Chaperone
IH404_RS11515	COG3188	usher protein
IH404_RS11525	COG2197	response regulator
IH404_RS11530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS11530	COG2205	protein histidine kinase activity
IH404_RS11540	COG0784	Response regulator, receiver
IH404_RS11540	COG2205	protein histidine kinase activity
IH404_RS11555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IH404_RS11575	COG2831	hemolysin activation secretion protein
IH404_RS11620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IH404_RS11635	COG2207	Transcriptional regulator
IH404_RS11645	COG1566	PFAM secretion protein HlyD family protein
IH404_RS11650	COG1289	transmembrane transporter activity
IH404_RS11655	COG0583	DNA-binding transcription factor activity
IH404_RS11670	COG2203	Gaf domain
IH404_RS11670	COG5001	Diguanylate cyclase
IH404_RS11670	COG4251	negative regulation of phosphorylation
IH404_RS11670	COG3706	GGDEF domain
IH404_RS11695	COG2207	Transcriptional regulator
IH404_RS11700	COG5001	Diguanylate cyclase
IH404_RS11700	COG4251	negative regulation of phosphorylation
IH404_RS11700	COG3706	GGDEF domain
IH404_RS11700	COG2203	Gaf domain
IH404_RS11710	COG2197	response regulator
IH404_RS11715	COG0784	Response regulator, receiver
IH404_RS11715	COG2205	protein histidine kinase activity
IH404_RS11715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS11715	COG2198	Histidine kinase
IH404_RS11720	COG2205	protein histidine kinase activity
IH404_RS11720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS11730	COG3121	Chaperone
IH404_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS11825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS11850	COG4214	carbohydrate transport
IH404_RS11855	COG1129	ABC transporter
IH404_RS11860	COG4213	ABC transporter substrate-binding protein
IH404_RS11865	COG2115	Belongs to the xylose isomerase family
IH404_RS11870	COG2207	Transcriptional regulator
IH404_RS11870	COG1609	Transcriptional regulator
IH404_RS11890	COG1021	2,3-dihydroxybenzoate-AMP ligase
IH404_RS11930	COG1132	(ABC) transporter
IH404_RS11930	COG2375	cellular response to nickel ion
IH404_RS11935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IH404_RS11935	COG2226	methyltransferase
IH404_RS11935	COG3433	isochorismatase activity
IH404_RS11945	COG1131	(ABC) transporter
IH404_RS11955	COG4771	TonB-dependent receptor
IH404_RS11960	COG4771	TonB-dependent receptor
IH404_RS11980	COG3781	membrane
IH404_RS11995	COG0640	Transcriptional regulator
IH404_RS12000	COG1902	pentaerythritol trinitrate reductase activity
IH404_RS12035	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS12045	COG1879	ABC-type sugar transport system periplasmic component
IH404_RS12050	COG1129	ABC transporter
IH404_RS12055	COG1172	Belongs to the binding-protein-dependent transport system permease family
IH404_RS12060	COG1879	ABC-type sugar transport system periplasmic component
IH404_RS12070	COG1172	Belongs to the binding-protein-dependent transport system permease family
IH404_RS12075	COG1063	alcohol dehydrogenase
IH404_RS12080	COG1070	Carbohydrate kinase
IH404_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS12090	COG1609	Transcriptional regulator
IH404_RS12135	COG2186	Transcriptional regulator
IH404_RS12145	COG1538	Outer membrane efflux protein
IH404_RS12150	COG1136	(ABC) transporter
IH404_RS12150	COG0577	efflux transmembrane transporter activity
IH404_RS12155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS12205	COG2423	ornithine cyclodeaminase activity
IH404_RS12225	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS12260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IH404_RS12260	COG0475	glutathione-regulated potassium exporter activity
IH404_RS12275	COG1396	sequence-specific DNA binding
IH404_RS12290	COG0583	DNA-binding transcription factor activity
IH404_RS12320	COG1063	alcohol dehydrogenase
IH404_RS12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS12375	COG1177	transmembrane transport
IH404_RS12380	COG1176	ABC-type spermidine putrescine transport system, permease component I
IH404_RS12385	COG3842	ATPase activity
IH404_RS12390	COG1414	Transcriptional regulator
IH404_RS12395	COG0534	Mate efflux family protein
IH404_RS12400	COG1309	transcriptional regulator
IH404_RS12475	COG1741	Belongs to the pirin family
IH404_RS12495	COG1917	Cupin 2, conserved barrel domain protein
IH404_RS12495	COG4977	sequence-specific DNA binding
IH404_RS12510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IH404_RS12515	COG1335	isochorismatase
IH404_RS12520	COG0583	DNA-binding transcription factor activity
IH404_RS12525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IH404_RS12530	COG1960	acyl-CoA dehydrogenase activity
IH404_RS12550	COG0583	DNA-binding transcription factor activity
IH404_RS12555	COG0235	Class ii aldolase
IH404_RS12570	COG2066	Belongs to the glutaminase family
IH404_RS12585	COG0019	diaminopimelate decarboxylase activity
IH404_RS12590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IH404_RS12605	COG0625	glutathione transferase activity
IH404_RS12640	COG2205	protein histidine kinase activity
IH404_RS12645	COG0745	RESPONSE REGULATOR receiver
IH404_RS12670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IH404_RS12680	COG3718	enzyme involved in inositol metabolism
IH404_RS12690	COG3962	Belongs to the TPP enzyme family
IH404_RS12695	COG0673	inositol 2-dehydrogenase activity
IH404_RS12700	COG0673	inositol 2-dehydrogenase activity
IH404_RS12715	COG1129	ABC transporter
IH404_RS12720	COG1172	Belongs to the binding-protein-dependent transport system permease family
IH404_RS12775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS12805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IH404_RS12840	COG0673	inositol 2-dehydrogenase activity
IH404_RS12850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IH404_RS12865	COG0587	DNA-directed DNA polymerase activity
IH404_RS12870	COG4191	Histidine kinase
IH404_RS12870	COG0784	Response regulator, receiver
IH404_RS12890	COG5383	Protein conserved in bacteria
IH404_RS12915	COG2267	carboxylic ester hydrolase activity
IH404_RS12920	COG3239	Fatty acid desaturase
IH404_RS12945	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS12955	COG0183	Belongs to the thiolase family
IH404_RS12960	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS12965	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IH404_RS12970	COG0673	inositol 2-dehydrogenase activity
IH404_RS12995	COG2706	6-phosphogluconolactonase activity
IH404_RS13015	COG0420	3'-5' exonuclease activity
IH404_RS13045	COG0714	Associated with various cellular activities
IH404_RS13060	COG2186	Transcriptional regulator
IH404_RS13075	COG2818	Glycosylase
IH404_RS13090	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS13100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IH404_RS13115	COG0814	amino acid
IH404_RS13130	COG0589	response to stress
IH404_RS13145	COG0745	RESPONSE REGULATOR receiver
IH404_RS13150	COG2205	protein histidine kinase activity
IH404_RS13165	COG0583	DNA-binding transcription factor activity
IH404_RS13170	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IH404_RS13175	COG1960	acyl-CoA dehydrogenase activity
IH404_RS13180	COG2079	MmgE PrpD family protein
IH404_RS13230	COG0697	spore germination
IH404_RS13235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS13250	COG0154	amidase activity
IH404_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS13290	COG0673	inositol 2-dehydrogenase activity
IH404_RS13295	COG2223	nitrite transmembrane transporter activity
IH404_RS13300	COG2207	Transcriptional regulator
IH404_RS13310	COG2207	Transcriptional regulator
IH404_RS13325	COG0519	Catalyzes the synthesis of GMP from XMP
IH404_RS13330	COG2271	Major facilitator Superfamily
IH404_RS13335	COG2267	carboxylic ester hydrolase activity
IH404_RS13345	COG0583	DNA-binding transcription factor activity
IH404_RS13375	COG1335	isochorismatase
IH404_RS13380	COG1944	ATP diphosphatase activity
IH404_RS13385	COG0626	cystathionine gamma-synthase activity
IH404_RS13410	COG2814	Major facilitator Superfamily
IH404_RS13450	COG5002	protein histidine kinase activity
IH404_RS13460	COG1595	DNA-templated transcription, initiation
IH404_RS13465	COG3712	iron ion homeostasis
IH404_RS13475	COG0583	DNA-binding transcription factor activity
IH404_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS13480	COG0604	alcohol dehydrogenase
IH404_RS13480	COG3321	synthase
IH404_RS13485	COG0840	transmembrane signaling receptor activity
IH404_RS13540	COG1640	4-alpha-glucanotransferase
IH404_RS13545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IH404_RS13550	COG0297	glycogen (starch) synthase activity
IH404_RS13555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IH404_RS13560	COG0596	Alpha beta hydrolase
IH404_RS13565	COG1238	metal cluster binding
IH404_RS13600	COG1116	anion transmembrane transporter activity
IH404_RS13600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS13605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS13610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IH404_RS13630	COG2366	antibiotic biosynthetic process
IH404_RS13640	COG0583	DNA-binding transcription factor activity
IH404_RS13695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IH404_RS13700	COG3938	Belongs to the proline racemase family
IH404_RS13705	COG0531	amino acid
IH404_RS13730	COG0583	DNA-binding transcription factor activity
IH404_RS13735	COG0521	Mo-molybdopterin cofactor biosynthetic process
IH404_RS13740	COG0303	'Molybdopterin
IH404_RS13755	COG0315	cyclic pyranopterin monophosphate synthase activity
IH404_RS13760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IH404_RS13770	COG1271	oxidase subunit
IH404_RS13775	COG1294	oxidase, subunit
IH404_RS13785	COG1335	isochorismatase
IH404_RS13790	COG1335	isochorismatase
IH404_RS13805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IH404_RS13815	COG0581	inorganic phosphate transmembrane transporter activity
IH404_RS13820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IH404_RS13835	COG2831	hemolysin activation secretion protein
IH404_RS13865	COG0778	Nitroreductase
IH404_RS13935	COG0307	riboflavin synthase, alpha
IH404_RS13970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IH404_RS14240	COG3617	BRO family, N-terminal domain
IH404_RS14285	COG2135	peptidase activity
IH404_RS14365	COG0640	Transcriptional regulator
IH404_RS14375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IH404_RS14395	COG0488	(ABC) transporter
IH404_RS14405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IH404_RS14425	COG2169	Transcriptional regulator
IH404_RS14425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IH404_RS14430	COG3145	DNA-N1-methyladenine dioxygenase activity
IH404_RS14465	COG3539	Fimbrial protein
IH404_RS14470	COG3539	Fimbrial protein
IH404_RS14475	COG3539	Fimbrial protein
IH404_RS14485	COG3121	Chaperone
IH404_RS14490	COG3188	usher protein
IH404_RS14555	COG2200	EAL domain
IH404_RS14575	COG0667	Aldo Keto reductase
IH404_RS14580	COG0583	DNA-binding transcription factor activity
IH404_RS14595	COG2271	Major facilitator Superfamily
IH404_RS14600	COG3835	regulator
IH404_RS14605	COG1929	Belongs to the glycerate kinase type-1 family
IH404_RS14630	COG1247	-acetyltransferase
IH404_RS14635	COG1794	racemase activity, acting on amino acids and derivatives
IH404_RS14640	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IH404_RS14670	COG2198	Histidine kinase
IH404_RS14670	COG2205	protein histidine kinase activity
IH404_RS14670	COG0784	Response regulator, receiver
IH404_RS14675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IH404_RS14685	COG0784	Response regulator, receiver
IH404_RS14685	COG2205	protein histidine kinase activity
IH404_RS14685	COG5002	protein histidine kinase activity
IH404_RS14705	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IH404_RS14715	COG3781	membrane
IH404_RS14720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IH404_RS14735	COG1960	acyl-CoA dehydrogenase activity
IH404_RS14740	COG1024	Enoyl-CoA hydratase
IH404_RS14745	COG1960	acyl-CoA dehydrogenase activity
IH404_RS14750	COG1024	Enoyl-CoA hydratase
IH404_RS14775	COG2076	Multidrug Resistance protein
IH404_RS14780	COG2076	Multidrug Resistance protein
IH404_RS14785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IH404_RS14790	COG0726	polysaccharide deacetylase
IH404_RS14795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IH404_RS14795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IH404_RS14800	COG0463	Glycosyl transferase, family 2
IH404_RS14810	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IH404_RS14815	COG2814	Major facilitator Superfamily
IH404_RS14820	COG0840	transmembrane signaling receptor activity
IH404_RS14880	COG5290	Psort location Cytoplasmic, score
IH404_RS14885	COG0210	DNA helicase
IH404_RS14890	COG0210	DNA helicase
IH404_RS14895	COG0494	nUDIX hydrolase
IH404_RS14900	COG2433	Pfam Transposase IS66
IH404_RS14910	COG2963	transposase activity
IH404_RS14960	COG1111	helicase
IH404_RS14960	COG1205	dead DEAH box helicase
IH404_RS15025	COG0084	hydrolase, TatD family'
IH404_RS15070	COG4774	siderophore transport
IH404_RS15075	COG4607	ABC-type enterochelin transport system periplasmic component
IH404_RS15080	COG4604	ABC transporter, ATP-binding protein
IH404_RS15085	COG4605	iron ion homeostasis
IH404_RS15090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IH404_RS15100	COG2375	cellular response to nickel ion
IH404_RS15100	COG1132	(ABC) transporter
IH404_RS15110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IH404_RS15125	COG1169	isochorismate synthase
IH404_RS15130	COG1021	2,3-dihydroxybenzoate-AMP ligase
IH404_RS15145	COG0583	DNA-binding transcription factor activity
IH404_RS15155	COG0583	DNA-binding transcription factor activity
IH404_RS15160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IH404_RS15165	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IH404_RS15170	COG0446	pyridine nucleotide-disulphide oxidoreductase
IH404_RS15185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IH404_RS15215	COG2146	nitrite reductase [NAD(P)H] activity
IH404_RS15215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IH404_RS15225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IH404_RS15230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IH404_RS15230	COG1024	Enoyl-CoA hydratase
IH404_RS15235	COG0583	DNA-binding transcription factor activity
IH404_RS15245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IH404_RS15275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IH404_RS15285	COG0826	peptidase U32
IH404_RS15295	COG1522	sequence-specific DNA binding
IH404_RS15325	COG2308	Evidence 4 Homologs of previously reported genes of
IH404_RS15335	COG0513	Belongs to the DEAD box helicase family
IH404_RS15350	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IH404_RS15395	COG1113	amino acid transport
IH404_RS15415	COG0210	DNA helicase
IH404_RS15430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS15440	COG0604	alcohol dehydrogenase
IH404_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS15440	COG3321	synthase
IH404_RS15490	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS15510	COG2814	Major facilitator Superfamily
IH404_RS15515	COG1538	Outer membrane efflux protein
IH404_RS15520	COG0583	DNA-binding transcription factor activity
IH404_RS15550	COG2207	Transcriptional regulator
IH404_RS15555	COG0672	)-iron permease
IH404_RS15560	COG2822	iron ion transport
IH404_RS15570	COG2822	iron ion transport
IH404_RS15575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IH404_RS15590	COG2133	pyrroloquinoline quinone binding
IH404_RS15600	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IH404_RS15635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IH404_RS15640	COG0488	(ABC) transporter
IH404_RS15655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IH404_RS15660	COG0583	DNA-binding transcription factor activity
IH404_RS15675	COG1968	undecaprenyl-diphosphatase activity
IH404_RS15680	COG0840	transmembrane signaling receptor activity
IH404_RS15700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IH404_RS15710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IH404_RS15745	COG2816	NAD+ diphosphatase activity
IH404_RS15750	COG1024	Enoyl-CoA hydratase
IH404_RS15755	COG3318	Belongs to the UPF0149 family
IH404_RS15755	COG3012	SEC-C Motif Domain Protein
IH404_RS15760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IH404_RS15770	COG2249	NAD(P)H dehydrogenase (quinone) activity
IH404_RS15790	COG0784	Response regulator, receiver
IH404_RS15790	COG4191	Histidine kinase
IH404_RS15800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IH404_RS15825	COG1285	pathogenesis
IH404_RS15835	COG0348	domain, Protein
IH404_RS15840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS15855	COG1538	Outer membrane efflux protein
IH404_RS15900	COG1175	transmembrane transport
IH404_RS15915	COG0246	Mannitol dehydrogenase
IH404_RS15920	COG1070	Carbohydrate kinase
IH404_RS15935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IH404_RS15945	COG0024	Methionine aminopeptidase
IH404_RS15960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IH404_RS15970	COG0730	response to heat
IH404_RS15980	COG2205	protein histidine kinase activity
IH404_RS15985	COG0745	RESPONSE REGULATOR receiver
IH404_RS15990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS16015	COG1609	Transcriptional regulator
IH404_RS16025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IH404_RS16040	COG2233	PERMEase
IH404_RS16055	COG0583	DNA-binding transcription factor activity
IH404_RS16120	COG2204	response regulator
IH404_RS16130	COG0561	phosphatase activity
IH404_RS16135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IH404_RS16140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IH404_RS16150	COG2194	sulfuric ester hydrolase activity
IH404_RS16170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IH404_RS16175	COG0308	aminopeptidase N
IH404_RS16185	COG3139	Protein of unknown function (DUF1315)
IH404_RS16195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IH404_RS16200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IH404_RS16255	COG0316	Belongs to the HesB IscA family
IH404_RS16255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IH404_RS16260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IH404_RS16310	COG0028	Belongs to the TPP enzyme family
IH404_RS16315	COG0431	NADPH-dependent FMN reductase
IH404_RS16350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IH404_RS16355	COG0328	RNA-DNA hybrid ribonuclease activity
IH404_RS16365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IH404_RS16370	COG0741	lytic transglycosylase activity
IH404_RS16370	COG1388	LysM domain
IH404_RS16375	COG4166	transmembrane transport
IH404_RS16380	COG4166	transmembrane transport
IH404_RS16385	COG4174	ABC transporter (Permease)
IH404_RS16390	COG4239	(ABC) transporter, permease
IH404_RS16395	COG4172	Belongs to the ABC transporter superfamily
IH404_RS16415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IH404_RS16430	COG0515	serine threonine protein kinase
IH404_RS16430	COG2815	serine threonine protein kinase
IH404_RS16470	COG2204	response regulator
IH404_RS16510	COG0656	L-ascorbic acid biosynthetic process
IH404_RS16520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IH404_RS16525	COG4166	transmembrane transport
IH404_RS16530	COG4174	ABC transporter (Permease)
IH404_RS16535	COG4239	(ABC) transporter, permease
IH404_RS16540	COG4172	Belongs to the ABC transporter superfamily
IH404_RS16545	COG3290	protein histidine kinase activity
IH404_RS16545	COG3829	transcription factor binding
IH404_RS16550	COG2610	gluconate transmembrane transporter activity
IH404_RS16555	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS16560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IH404_RS16570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IH404_RS16575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IH404_RS16595	COG1126	abc transporter atp-binding protein
IH404_RS16600	COG0765	amino acid transport
IH404_RS16605	COG0765	amino acid transport
IH404_RS16620	COG1253	flavin adenine dinucleotide binding
IH404_RS16630	COG0698	ribose 5-phosphate isomerase
IH404_RS16635	COG1129	ABC transporter
IH404_RS16640	COG1172	Belongs to the binding-protein-dependent transport system permease family
IH404_RS16645	COG1879	ABC-type sugar transport system periplasmic component
IH404_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS16655	COG1063	alcohol dehydrogenase
IH404_RS16660	COG2376	Dihydroxyacetone kinase
IH404_RS16670	COG0583	DNA-binding transcription factor activity
IH404_RS16680	COG0616	signal peptide processing
IH404_RS16695	COG0494	nUDIX hydrolase
IH404_RS16700	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS16710	COG1304	FMN binding
IH404_RS16715	COG1349	DNA-binding transcription factor activity
IH404_RS16730	COG0693	protein deglycase activity
IH404_RS16780	COG1999	signal sequence binding
IH404_RS16830	COG0596	Alpha beta hydrolase
IH404_RS16840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IH404_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS16865	COG0583	DNA-binding transcription factor activity
IH404_RS16870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS16880	COG0174	glutamine synthetase
IH404_RS16895	COG2814	Major facilitator Superfamily
IH404_RS16905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IH404_RS16920	COG2814	Major facilitator Superfamily
IH404_RS16925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS16930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IH404_RS16935	COG3209	COG3209 Rhs family protein
IH404_RS16965	COG3706	GGDEF domain
IH404_RS16985	COG1522	sequence-specific DNA binding
IH404_RS17000	COG0577	efflux transmembrane transporter activity
IH404_RS17000	COG1136	(ABC) transporter
IH404_RS17005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS17025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS17030	COG2814	Major facilitator Superfamily
IH404_RS17055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IH404_RS17090	COG0395	ABC-type sugar transport system, permease component
IH404_RS17100	COG3842	ATPase activity
IH404_RS17105	COG3842	ATPase activity
IH404_RS17110	COG3284	Transcriptional regulator
IH404_RS17150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IH404_RS17155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IH404_RS17160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IH404_RS17165	COG2835	tetraacyldisaccharide 4'-kinase activity
IH404_RS17170	COG1663	tetraacyldisaccharide 4'-kinase activity
IH404_RS17175	COG0848	biopolymer transport protein
IH404_RS17180	COG0811	peptide transport
IH404_RS17185	COG0658	competence protein
IH404_RS17185	COG2333	competence protein COMEC
IH404_RS17205	COG0784	Response regulator, receiver
IH404_RS17205	COG5002	protein histidine kinase activity
IH404_RS17205	COG2205	protein histidine kinase activity
IH404_RS17210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IH404_RS17235	COG1393	Belongs to the ArsC family
IH404_RS17255	COG0037	tRNA processing
IH404_RS17265	COG3091	SprT-like family
IH404_RS17270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IH404_RS17295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IH404_RS17300	COG0435	Glutathione S-transferase
IH404_RS17305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IH404_RS17305	COG1648	precorrin-2 dehydrogenase activity
IH404_RS17310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IH404_RS17315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IH404_RS17320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IH404_RS17325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IH404_RS17330	COG1674	ftsk spoiiie
IH404_RS17335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IH404_RS17340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IH404_RS17345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IH404_RS17350	COG0542	response to heat
IH404_RS17355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IH404_RS17360	COG1278	Cold shock
IH404_RS17380	COG0482	sulfurtransferase activity
IH404_RS17385	COG2915	High frequency lysogenization protein hflD homolog
IH404_RS17395	COG2850	peptidyl-arginine hydroxylation
IH404_RS17400	COG2153	protein acetylation
IH404_RS17410	COG2224	Isocitrate lyase
IH404_RS17415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IH404_RS17420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IH404_RS17425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IH404_RS17425	COG0649	NAD binding
IH404_RS17440	COG1034	ATP synthesis coupled electron transport
IH404_RS17445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IH404_RS17450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IH404_RS17460	COG0713	ATP synthesis coupled electron transport
IH404_RS17475	COG1007	ATP synthesis coupled electron transport
IH404_RS17550	COG0577	efflux transmembrane transporter activity
IH404_RS17550	COG1136	(ABC) transporter
IH404_RS17555	COG0577	efflux transmembrane transporter activity
IH404_RS17555	COG1136	(ABC) transporter
IH404_RS17565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS17595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IH404_RS17595	COG2111	Na H antiporter
IH404_RS17600	COG1006	Multisubunit Na H antiporter MnhC subunit
IH404_RS17605	COG0651	ATP synthesis coupled electron transport
IH404_RS17615	COG2212	antiporter activity
IH404_RS17620	COG1320	monovalent cation:proton antiporter activity
IH404_RS17630	COG0215	cysteine-tRNA ligase activity
IH404_RS17635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IH404_RS17645	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IH404_RS17650	COG2814	Major facilitator Superfamily
IH404_RS17655	COG1566	PFAM secretion protein HlyD family protein
IH404_RS17665	COG1846	Transcriptional regulator
IH404_RS17670	COG2911	Protein conserved in bacteria
IH404_RS17675	COG0729	surface antigen
IH404_RS17685	COG0708	Exodeoxyribonuclease III
IH404_RS17690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IH404_RS17695	COG1960	acyl-CoA dehydrogenase activity
IH404_RS17705	COG0789	Transcriptional regulator
IH404_RS17720	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS17725	COG1960	acyl-CoA dehydrogenase activity
IH404_RS17730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IH404_RS17755	COG2866	Carboxypeptidase
IH404_RS17760	COG3038	cytochrome b561
IH404_RS17830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IH404_RS17840	COG0217	transcriptional regulatory protein
IH404_RS17845	COG2271	Major facilitator Superfamily
IH404_RS17855	COG0583	DNA-binding transcription factor activity
IH404_RS17860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IH404_RS17865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IH404_RS17870	COG3038	cytochrome b561
IH404_RS17880	COG0446	pyridine nucleotide-disulphide oxidoreductase
IH404_RS17880	COG1902	pentaerythritol trinitrate reductase activity
IH404_RS17895	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IH404_RS17900	COG1846	Transcriptional regulator
IH404_RS17905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IH404_RS17915	COG0583	DNA-binding transcription factor activity
IH404_RS17920	COG2814	Major facilitator Superfamily
IH404_RS17925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IH404_RS17930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IH404_RS17935	COG0776	regulation of translation
IH404_RS17940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IH404_RS17945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IH404_RS17950	COG0740	serine-type endopeptidase activity
IH404_RS17955	COG0544	peptidyl-prolyl cis-trans isomerase activity
IH404_RS17980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IH404_RS17985	COG1686	Belongs to the peptidase S11 family
IH404_RS18015	COG1538	Outer membrane efflux protein
IH404_RS18025	COG1953	Uracil, thiamine, allantoin
IH404_RS18045	COG1309	transcriptional regulator
IH404_RS18065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IH404_RS18075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IH404_RS18115	COG0640	Transcriptional regulator
IH404_RS18125	COG1522	sequence-specific DNA binding
IH404_RS18130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IH404_RS18135	COG0022	dehydrogenase e1 component
IH404_RS18145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IH404_RS18150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IH404_RS18175	COG0604	alcohol dehydrogenase
IH404_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS18175	COG3321	synthase
IH404_RS18180	COG1902	pentaerythritol trinitrate reductase activity
IH404_RS18190	COG1309	transcriptional regulator
IH404_RS18205	COG1968	undecaprenyl-diphosphatase activity
IH404_RS18245	COG0673	inositol 2-dehydrogenase activity
IH404_RS18260	COG0625	glutathione transferase activity
IH404_RS18270	COG2207	Transcriptional regulator
IH404_RS18325	COG0406	alpha-ribazole phosphatase activity
IH404_RS18330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IH404_RS18335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IH404_RS18340	COG0583	DNA-binding transcription factor activity
IH404_RS18390	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS18395	COG3384	dioxygenase
IH404_RS18405	COG2271	Major facilitator Superfamily
IH404_RS18410	COG3971	2-oxopent-4-enoate hydratase activity
IH404_RS18420	COG1846	Transcriptional regulator
IH404_RS18425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS18460	COG0531	amino acid
IH404_RS18475	COG1960	acyl-CoA dehydrogenase activity
IH404_RS18480	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS18515	COG0583	DNA-binding transcription factor activity
IH404_RS18525	COG0625	glutathione transferase activity
IH404_RS18530	COG0667	Aldo Keto reductase
IH404_RS18545	COG3121	Chaperone
IH404_RS18555	COG2205	protein histidine kinase activity
IH404_RS18555	COG0784	Response regulator, receiver
IH404_RS18560	COG2199	diguanylate cyclase activity
IH404_RS18560	COG2203	Gaf domain
IH404_RS18560	COG2200	EAL domain
IH404_RS18565	COG2205	protein histidine kinase activity
IH404_RS18565	COG0784	Response regulator, receiver
IH404_RS18570	COG2197	response regulator
IH404_RS18580	COG3121	Chaperone
IH404_RS18610	COG1231	oxidoreductase activity
IH404_RS18615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS18620	COG1126	abc transporter atp-binding protein
IH404_RS18635	COG1450	Type ii and iii secretion system protein
IH404_RS18655	COG3156	type II secretion system protein K
IH404_RS18665	COG2165	general secretion pathway protein
IH404_RS18670	COG2165	general secretion pathway protein
IH404_RS18675	COG2165	general secretion pathway protein
IH404_RS18680	COG1459	type II secretion system
IH404_RS18685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IH404_RS18690	COG1609	Transcriptional regulator
IH404_RS18700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IH404_RS18705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS18775	COG0776	regulation of translation
IH404_RS18780	COG0072	phenylalanine-tRNA ligase activity
IH404_RS18785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IH404_RS18790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IH404_RS18795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IH404_RS18800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IH404_RS18805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IH404_RS18815	COG1278	Cold shock
IH404_RS18840	COG1869	D-ribose catabolic process
IH404_RS18845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IH404_RS18850	COG1609	Transcriptional regulator
IH404_RS18855	COG1172	Belongs to the binding-protein-dependent transport system permease family
IH404_RS18860	COG1129	ABC transporter
IH404_RS18890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IH404_RS18900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IH404_RS18915	COG0642	Histidine kinase
IH404_RS18945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS18950	COG2010	Cytochrome c
IH404_RS18960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IH404_RS19000	COG1286	toxin biosynthetic process
IH404_RS19005	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IH404_RS19010	COG0285	dihydrofolate synthase activity
IH404_RS19015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IH404_RS19020	COG0135	phosphoribosylanthranilate isomerase activity
IH404_RS19045	COG0473	3-isopropylmalate dehydrogenase activity
IH404_RS19050	COG2226	methyltransferase
IH404_RS19055	COG0066	3-isopropylmalate dehydratase activity
IH404_RS19060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IH404_RS19075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IH404_RS19110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IH404_RS19115	COG0556	nucleotide-excision repair
IH404_RS19130	COG0583	DNA-binding transcription factor activity
IH404_RS19135	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS19150	COG1864	DNA RNA non-specific endonuclease
IH404_RS19150	COG3591	Belongs to the peptidase S1B family
IH404_RS19155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IH404_RS19160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IH404_RS19165	COG1120	ATPase activity
IH404_RS19180	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IH404_RS19285	COG2384	SAM-dependent methyltransferase
IH404_RS19290	COG2186	Transcriptional regulator
IH404_RS19305	COG3469	chitinase activity
IH404_RS19320	COG3657	addiction module killer protein
IH404_RS19325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IH404_RS19345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS19350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IH404_RS19375	COG2391	methyltransferase activity
IH404_RS19390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IH404_RS19400	COG0642	Histidine kinase
IH404_RS19405	COG0745	RESPONSE REGULATOR receiver
IH404_RS19415	COG2814	Major facilitator Superfamily
IH404_RS19420	COG0583	DNA-binding transcription factor activity
IH404_RS19440	COG0583	DNA-binding transcription factor activity
IH404_RS19445	COG1304	FMN binding
IH404_RS19460	COG5001	Diguanylate cyclase
IH404_RS19460	COG5002	protein histidine kinase activity
IH404_RS19475	COG1054	Belongs to the UPF0176 family
IH404_RS19515	COG0271	Belongs to the BolA IbaG family
IH404_RS19525	COG0114	fumarate hydratase activity
IH404_RS19530	COG0697	spore germination
IH404_RS19535	COG0183	Belongs to the thiolase family
IH404_RS19540	COG2326	polyphosphate kinase activity
IH404_RS19550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IH404_RS19550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IH404_RS19555	COG0367	asparagine synthase
IH404_RS19560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IH404_RS19560	COG0189	ligase activity
IH404_RS19570	COG3089	Belongs to the UPF0270 family
IH404_RS19575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IH404_RS19590	COG1368	sulfuric ester hydrolase activity
IH404_RS19610	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS19620	COG2197	response regulator
IH404_RS19625	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IH404_RS19635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IH404_RS19640	COG1073	alpha beta
IH404_RS19665	COG2840	Smr protein MutS2
IH404_RS19670	COG0302	gtp cyclohydrolase
IH404_RS19690	COG2851	Citrate transporter
IH404_RS19695	COG0583	DNA-binding transcription factor activity
IH404_RS19700	COG0625	glutathione transferase activity
IH404_RS19705	COG2252	PERMEase
IH404_RS19735	COG4266	Belongs to the allantoicase family
IH404_RS19740	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IH404_RS19750	COG2233	PERMEase
IH404_RS19770	COG1560	Kdo2-lipid A biosynthetic process
IH404_RS19775	COG0850	regulation of cytokinetic process
IH404_RS19780	COG2894	cell division
IH404_RS19785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IH404_RS19790	COG0564	pseudouridine synthase activity
IH404_RS19795	COG1362	aminopeptidase activity
IH404_RS19805	COG0668	transmembrane transport
IH404_RS19820	COG3023	N-Acetylmuramoyl-L-alanine amidase
IH404_RS19840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IH404_RS19870	COG1309	transcriptional regulator
IH404_RS19885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IH404_RS19890	COG1960	acyl-CoA dehydrogenase activity
IH404_RS19895	COG1024	Enoyl-CoA hydratase
IH404_RS19910	COG3123	guanosine phosphorylase activity
IH404_RS19915	COG3217	Mosc domain protein beta barrel domain protein
IH404_RS19915	COG0633	Ferredoxin
IH404_RS19930	COG3851	Histidine kinase
IH404_RS19935	COG2197	response regulator
IH404_RS19940	COG1597	lipid kinase activity
IH404_RS19960	COG1192	Involved in chromosome partitioning
IH404_RS19965	COG1360	Flagellar Motor Protein
IH404_RS19970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IH404_RS19975	COG2201	protein-glutamate methylesterase activity
IH404_RS19980	COG2198	Histidine kinase
IH404_RS19980	COG0784	Response regulator, receiver
IH404_RS19980	COG0643	Histidine kinase
IH404_RS19985	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IH404_RS20020	COG1278	Cold shock
IH404_RS20030	COG1278	Cold shock
IH404_RS20085	COG0745	RESPONSE REGULATOR receiver
IH404_RS20120	COG1677	Flagellar hook-basal body complex protein FliE
IH404_RS20150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IH404_RS20160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IH404_RS20165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IH404_RS20175	COG1256	bacterial-type flagellum assembly
IH404_RS20185	COG1706	bacterial-type flagellum-dependent cell motility
IH404_RS20190	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IH404_RS20200	COG4787	bacterial-type flagellum-dependent cell motility
IH404_RS20220	COG2154	pterin-4-alpha-carbinolamine dehydratase
IH404_RS20235	COG2207	Transcriptional regulator
IH404_RS20255	COG1752	Esterase of the alpha-beta hydrolase superfamily
IH404_RS20260	COG1846	Transcriptional regulator
IH404_RS20265	COG0514	ATP-dependent DNA helicase (RecQ)
IH404_RS20275	COG2832	Protein of unknown function (DUF454)
IH404_RS20280	COG0784	Response regulator, receiver
IH404_RS20280	COG2198	Histidine kinase
IH404_RS20280	COG2205	protein histidine kinase activity
IH404_RS20325	COG1846	Transcriptional regulator
IH404_RS20330	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IH404_RS20335	COG0406	alpha-ribazole phosphatase activity
IH404_RS20340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IH404_RS20350	COG1492	cobalamin metabolic process
IH404_RS20360	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IH404_RS20365	COG0778	Nitroreductase
IH404_RS20370	COG1797	cobyrinic acid a,c-diamide synthase activity
IH404_RS20385	COG0791	NLP P60 protein
IH404_RS20390	COG0791	NLP P60 protein
IH404_RS20395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IH404_RS20400	COG0628	permease
IH404_RS20410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IH404_RS20415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IH404_RS20430	COG3122	Protein conserved in bacteria
IH404_RS20435	COG3956	TIGRFAM MazG family protein
IH404_RS20440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IH404_RS20445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IH404_RS20470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IH404_RS20475	COG0583	DNA-binding transcription factor activity
IH404_RS20490	COG2996	Protein conserved in bacteria
IH404_RS20520	COG0513	Belongs to the DEAD box helicase family
IH404_RS20525	COG0668	transmembrane transport
IH404_RS20535	COG4221	oxidoreductase activity
IH404_RS20540	COG0604	alcohol dehydrogenase
IH404_RS20540	COG3321	synthase
IH404_RS20550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IH404_RS20570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IH404_RS20575	COG1132	(ABC) transporter
IH404_RS20580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IH404_RS20590	COG2188	Transcriptional regulator
IH404_RS20600	COG1595	DNA-templated transcription, initiation
IH404_RS20610	COG1643	Atp-dependent helicase
IH404_RS20615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IH404_RS20635	COG0840	transmembrane signaling receptor activity
IH404_RS20655	COG3278	Belongs to the heme-copper respiratory oxidase family
IH404_RS20670	COG2010	Cytochrome c
IH404_RS20675	COG3278	Belongs to the heme-copper respiratory oxidase family
IH404_RS20690	COG2010	Cytochrome c
IH404_RS20700	COG0348	domain, Protein
IH404_RS20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IH404_RS20740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IH404_RS20745	COG1960	acyl-CoA dehydrogenase activity
IH404_RS20750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IH404_RS20755	COG2130	NADP-dependent
IH404_RS20760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IH404_RS20765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IH404_RS20775	COG0583	DNA-binding transcription factor activity
IH404_RS20805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IH404_RS20810	COG3115	cell septum assembly
IH404_RS20830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IH404_RS20840	COG0402	S-adenosylhomocysteine deaminase activity
IH404_RS20845	COG1802	Transcriptional regulator
IH404_RS20850	COG3135	benzoate transporter
IH404_RS20855	COG3171	Protein conserved in bacteria
IH404_RS20870	COG0116	Belongs to the methyltransferase superfamily
IH404_RS20870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IH404_RS20875	COG3130	regulation of translation
IH404_RS20880	COG0167	dihydroorotate dehydrogenase activity
IH404_RS20905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS20905	COG1116	anion transmembrane transporter activity
IH404_RS20910	COG3707	response regulator
IH404_RS20915	COG2223	nitrite transmembrane transporter activity
IH404_RS20925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IH404_RS20930	COG2146	nitrite reductase [NAD(P)H] activity
IH404_RS20935	COG0243	molybdopterin cofactor binding
IH404_RS20940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IH404_RS20945	COG2885	chlorophyll binding
IH404_RS20945	COG3047	cAMP biosynthetic process
IH404_RS20970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IH404_RS20985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IH404_RS20990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS21005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IH404_RS21010	COG1045	serine acetyltransferase
IH404_RS21015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IH404_RS21020	COG2079	MmgE PrpD family protein
IH404_RS21035	COG0372	Belongs to the citrate synthase family
IH404_RS21045	COG1802	Transcriptional regulator
IH404_RS21050	COG4067	protein conserved in archaea
IH404_RS21050	COG0189	ligase activity
IH404_RS21060	COG0189	ligase activity
IH404_RS21070	COG0560	Phosphoserine phosphatase
IH404_RS21080	COG1953	Uracil, thiamine, allantoin
IH404_RS21090	COG0583	DNA-binding transcription factor activity
IH404_RS21095	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS21100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IH404_RS21140	COG0598	Magnesium transport protein CorA
IH404_RS21145	COG0519	Catalyzes the synthesis of GMP from XMP
IH404_RS21145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IH404_RS21150	COG1250	3-hydroxyacyl-CoA dehydrogenase
IH404_RS21150	COG1024	Enoyl-CoA hydratase
IH404_RS21155	COG0183	Belongs to the thiolase family
IH404_RS21175	COG2308	Evidence 4 Homologs of previously reported genes of
IH404_RS21205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS21210	COG2885	chlorophyll binding
IH404_RS21245	COG2207	Transcriptional regulator
IH404_RS21250	COG1064	alcohol dehydrogenase
IH404_RS21255	COG1414	Transcriptional regulator
IH404_RS21260	COG1172	Belongs to the binding-protein-dependent transport system permease family
IH404_RS21265	COG1129	ABC transporter
IH404_RS21270	COG1879	ABC-type sugar transport system periplasmic component
IH404_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS21300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IH404_RS21310	COG1397	ADP-ribosylglycohydrolase
IH404_RS21315	COG2188	Transcriptional regulator
IH404_RS21330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IH404_RS21340	COG0084	hydrolase, TatD family'
IH404_RS21350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IH404_RS21355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IH404_RS21365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IH404_RS21370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IH404_RS21385	COG0416	fatty acid biosynthetic process
IH404_RS21390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IH404_RS21400	COG0424	maF-like protein
IH404_RS21405	COG0616	signal peptide processing
IH404_RS21405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IH404_RS21410	COG0546	phosphoglycolate phosphatase activity
IH404_RS21420	COG1530	ribonuclease E activity
IH404_RS21425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IH404_RS21430	COG3608	succinylglutamate desuccinylase aspartoacylase
IH404_RS21430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IH404_RS21435	COG1301	dicarboxylic acid transport
IH404_RS21440	COG4977	sequence-specific DNA binding
IH404_RS21440	COG1917	Cupin 2, conserved barrel domain protein
IH404_RS21460	COG2977	Belongs to the P-Pant transferase superfamily
IH404_RS21465	COG2205	protein histidine kinase activity
IH404_RS21470	COG0745	RESPONSE REGULATOR receiver
IH404_RS21490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IH404_RS21500	COG1815	bacterial-type flagellum-dependent cell motility
IH404_RS21505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IH404_RS21510	COG0784	Response regulator, receiver
IH404_RS21510	COG0835	chemotaxis
IH404_RS21530	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IH404_RS21535	COG0477	Major facilitator Superfamily
IH404_RS21580	COG2239	Acts as a magnesium transporter
IH404_RS21600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IH404_RS21605	COG0527	aspartate kinase activity
IH404_RS21610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IH404_RS21615	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IH404_RS21620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IH404_RS21630	COG2988	succinylglutamate desuccinylase activity
IH404_RS21640	COG3724	N-succinylarginine dihydrolase activity
IH404_RS21645	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS21660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IH404_RS21700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS21705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IH404_RS21715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IH404_RS21740	COG0563	adenylate kinase activity
IH404_RS21785	COG0504	CTP synthase activity
IH404_RS21790	COG2329	Antibiotic biosynthesis monooxygenase
IH404_RS21800	COG0584	glycerophosphoryl diester phosphodiesterase
IH404_RS21815	COG0306	phosphate transporter
IH404_RS21820	COG1984	allophanate hydrolase subunit 2
IH404_RS21830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IH404_RS21840	COG0583	DNA-binding transcription factor activity
IH404_RS21845	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS21855	COG0583	DNA-binding transcription factor activity
IH404_RS21860	COG4941	Belongs to the sigma-70 factor family
IH404_RS21865	COG3795	YCII-related domain
IH404_RS21885	COG0436	Aminotransferase
IH404_RS21895	COG3265	gluconokinase activity
IH404_RS21900	COG1609	Transcriptional regulator
IH404_RS21920	COG2271	Major facilitator Superfamily
IH404_RS21940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS21965	COG0242	peptide deformylase activity
IH404_RS21970	COG1295	ribonuclease BN
IH404_RS21985	COG2814	Major facilitator Superfamily
IH404_RS21990	COG0028	Belongs to the TPP enzyme family
IH404_RS22000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IH404_RS22005	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS22010	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS22015	COG0318	PFAM AMP-dependent synthetase and ligase
IH404_RS22025	COG2030	dehydratase
IH404_RS22035	COG3530	Putative quorum-sensing-regulated virulence factor
IH404_RS22040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IH404_RS22045	COG0800	Aldolase
IH404_RS22060	COG1737	Transcriptional regulator
IH404_RS22065	COG0676	glucose-6-phosphate 1-epimerase activity
IH404_RS22075	COG3842	ATPase activity
IH404_RS22080	COG0395	ABC-type sugar transport system, permease component
IH404_RS22085	COG1175	transmembrane transport
IH404_RS22090	COG1653	transport
IH404_RS22105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IH404_RS22110	COG0583	DNA-binding transcription factor activity
IH404_RS22120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IH404_RS22140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IH404_RS22170	COG1113	amino acid transport
IH404_RS22195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IH404_RS22205	COG0009	L-threonylcarbamoyladenylate synthase
IH404_RS22210	COG0613	PHP domain protein
IH404_RS22215	COG2917	probably involved in intracellular septation
IH404_RS22220	COG2350	Protein conserved in bacteria
IH404_RS22225	COG0745	RESPONSE REGULATOR receiver
IH404_RS22235	COG0642	Histidine kinase
IH404_RS22285	COG0509	glycine decarboxylation via glycine cleavage system
IH404_RS22290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IH404_RS22290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IH404_RS22295	COG1760	l-serine dehydratase
IH404_RS22300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IH404_RS22305	COG1278	Cold shock
IH404_RS22315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IH404_RS22345	COG1538	Outer membrane efflux protein
IH404_RS22440	COG3210	domain, Protein
IH404_RS22450	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IH404_RS22470	COG0602	queuosine metabolic process
IH404_RS22475	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IH404_RS22480	COG2885	chlorophyll binding
IH404_RS22485	COG0823	Involved in the tonB-independent uptake of proteins
IH404_RS22505	COG0824	Thioesterase
IH404_RS22510	COG2255	four-way junction helicase activity
IH404_RS22515	COG0632	four-way junction helicase activity
IH404_RS22520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IH404_RS22525	COG0217	transcriptional regulatory protein
IH404_RS22530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IH404_RS22545	COG0783	Belongs to the Dps family
IH404_RS22555	COG2900	Belongs to the SlyX family
IH404_RS22570	COG0668	transmembrane transport
IH404_RS22575	COG1666	GTP binding
IH404_RS22585	COG4191	Histidine kinase
IH404_RS22585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS22590	COG2096	Adenosyltransferase
IH404_RS22600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IH404_RS22605	COG0653	protein targeting
IH404_RS22615	COG0433	COG0433 Predicted ATPase
IH404_RS22625	COG0438	transferase activity, transferring glycosyl groups
IH404_RS22625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IH404_RS22640	COG0788	formyltetrahydrofolate deformylase activity
IH404_RS22650	COG2925	Exonuclease
IH404_RS22675	COG0714	Associated with various cellular activities
IH404_RS22695	COG0469	pyruvate kinase activity
IH404_RS22700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IH404_RS22710	COG4191	Histidine kinase
IH404_RS22720	COG0477	Major facilitator Superfamily
IH404_RS22740	COG2207	Transcriptional regulator
IH404_RS22775	COG3712	iron ion homeostasis
IH404_RS22780	COG4771	TonB-dependent receptor
IH404_RS22790	COG2832	Protein of unknown function (DUF454)
IH404_RS22795	COG0840	transmembrane signaling receptor activity
IH404_RS22825	COG3642	lipopolysaccharide core region biosynthetic process
IH404_RS22835	COG0642	Histidine kinase
IH404_RS22845	COG1368	sulfuric ester hydrolase activity
IH404_RS22855	COG0459	protein refolding
IH404_RS22860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IH404_RS22890	COG0442	prolyl-tRNA aminoacylation
IH404_RS22900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IH404_RS22935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IH404_RS22945	COG2197	response regulator
IH404_RS22955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS22955	COG2205	protein histidine kinase activity
IH404_RS22975	COG4974	Belongs to the 'phage' integrase family
IH404_RS22980	COG3263	regulation of cellular component size
IH404_RS22985	COG1607	acyl-coa hydrolase
IH404_RS22990	COG0335	large ribosomal subunit rRNA binding
IH404_RS22995	COG0336	Belongs to the RNA methyltransferase TrmD family
IH404_RS23000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IH404_RS23005	COG0228	four-way junction DNA binding
IH404_RS23010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IH404_RS23020	COG4536	flavin adenine dinucleotide binding
IH404_RS23025	COG0477	Major facilitator Superfamily
IH404_RS23030	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IH404_RS23050	COG0494	nUDIX hydrolase
IH404_RS23065	COG2188	Transcriptional regulator
IH404_RS23070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IH404_RS23075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IH404_RS23080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IH404_RS23080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IH404_RS23085	COG2190	(PTS) system
IH404_RS23085	COG1263	PTS System
IH404_RS23085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IH404_RS23105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IH404_RS23110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IH404_RS23110	COG0047	phosphoribosylformylglycinamidine synthase activity
IH404_RS23115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IH404_RS23125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IH404_RS23125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IH404_RS23135	COG0366	Alpha amylase catalytic
IH404_RS23140	COG1263	PTS System
IH404_RS23140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IH404_RS23145	COG2188	Transcriptional regulator
IH404_RS23150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IH404_RS23150	COG0519	Catalyzes the synthesis of GMP from XMP
IH404_RS23175	COG1570	exodeoxyribonuclease VII activity
IH404_RS23180	COG0739	heme binding
IH404_RS23195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IH404_RS23205	COG0436	Aminotransferase
IH404_RS23210	COG1160	GTP binding
IH404_RS23225	COG0124	histidyl-tRNA synthetase
IH404_RS23230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IH404_RS23235	COG1426	Protein conserved in bacteria
IH404_RS23245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IH404_RS23250	COG0105	UTP biosynthetic process
IH404_RS23260	COG0633	Ferredoxin
IH404_RS23265	COG0443	Heat shock 70 kDa protein
IH404_RS23270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IH404_RS23275	COG0316	Belongs to the HesB IscA family
IH404_RS23285	COG1104	cysteine desulfurase activity
IH404_RS23295	COG1045	serine acetyltransferase
IH404_RS23310	COG3134	Outer membrane lipoprotein
IH404_RS23325	COG1862	Preprotein translocase
IH404_RS23330	COG0343	queuine tRNA-ribosyltransferase activity
IH404_RS23335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IH404_RS23365	COG1280	lysine exporter protein (LysE YggA)
IH404_RS23405	COG4251	negative regulation of phosphorylation
IH404_RS23425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IH404_RS23435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IH404_RS23450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IH404_RS23455	COG0109	protoheme IX farnesyltransferase activity
IH404_RS23470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IH404_RS23475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IH404_RS23480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IH404_RS23485	COG1017	nitric oxide dioxygenase activity
IH404_RS23485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IH404_RS23490	COG3604	Transcriptional regulator
IH404_RS23500	COG2207	Transcriptional regulator
IH404_RS23500	COG3708	Transcriptional regulator
IH404_RS23505	COG1028	Short-chain dehydrogenase reductase Sdr
IH404_RS23525	COG1366	Belongs to the anti-sigma-factor antagonist family
IH404_RS23550	COG0302	gtp cyclohydrolase
IH404_RS23555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IH404_RS23570	COG0492	ferredoxin-NADP+ reductase activity
IH404_RS23575	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IH404_RS23595	COG0386	Belongs to the glutathione peroxidase family
IH404_RS23600	COG3045	CreA protein
IH404_RS23605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IH404_RS23610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IH404_RS23615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IH404_RS23620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IH404_RS23625	COG0142	geranyltranstransferase activity
IH404_RS23630	COG2824	Alkylphosphonate utilization operon protein PhnA
IH404_RS23635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IH404_RS23640	COG0545	Peptidyl-prolyl cis-trans isomerase
IH404_RS23645	COG0840	transmembrane signaling receptor activity
IH404_RS23655	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IH404_RS23660	COG1737	Transcriptional regulator
IH404_RS23665	COG2610	gluconate transmembrane transporter activity
IH404_RS23675	COG0659	secondary active sulfate transmembrane transporter activity
IH404_RS23685	COG0583	DNA-binding transcription factor activity
IH404_RS23695	COG0583	DNA-binding transcription factor activity
IH404_RS23700	COG1113	amino acid transport
IH404_RS23710	COG1522	sequence-specific DNA binding
IH404_RS23715	COG3485	protocatechuate 3,4-dioxygenase
IH404_RS23725	COG4948	Mandelate Racemase Muconate Lactonizing
IH404_RS23740	COG4638	Rieske (2fe-2S)
IH404_RS23745	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IH404_RS23750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IH404_RS23750	COG0543	2 iron, 2 sulfur cluster binding
IH404_RS23755	COG1113	amino acid transport
IH404_RS23760	COG3483	tryptophan 2,3-dioxygenase activity
IH404_RS23765	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IH404_RS23795	COG2274	protein secretion by the type I secretion system
IH404_RS23855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IH404_RS23860	COG1074	ATP-dependent DNA helicase activity
IH404_RS23865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IH404_RS23895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IH404_RS23900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IH404_RS23905	COG1183	phosphatidylcholine synthase activity
IH404_RS23910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IH404_RS23920	COG0028	Belongs to the TPP enzyme family
IH404_RS23925	COG3098	single-species biofilm formation
IH404_RS23935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IH404_RS23955	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IH404_RS23960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IH404_RS23965	COG4558	Periplasmic binding protein
IH404_RS23975	COG1489	DNA binding
IH404_RS23980	COG0436	Aminotransferase
IH404_RS23990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IH404_RS24000	COG4191	Histidine kinase
IH404_RS24010	COG0617	tRNA 3'-terminal CCA addition
IH404_RS24020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IH404_RS24025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IH404_RS24030	COG0166	Belongs to the GPI family
IH404_RS24035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IH404_RS24040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IH404_RS24050	COG2823	Periplasmic or secreted lipoprotein
IH404_RS24055	COG1185	polyribonucleotide nucleotidyltransferase activity
IH404_RS24060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IH404_RS24065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IH404_RS24070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IH404_RS24075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IH404_RS24080	COG0195	Participates in both transcription termination and antitermination
IH404_RS24085	COG0779	Required for maturation of 30S ribosomal subunits
IH404_RS24100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IH404_RS24105	COG0149	triose-phosphate isomerase activity
IH404_RS24110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IH404_RS24115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IH404_RS24125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IH404_RS24140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IH404_RS24145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IH404_RS24150	COG0505	Belongs to the CarA family
IH404_RS24155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IH404_RS24160	COG0484	heat shock protein binding
IH404_RS24165	COG0443	Heat shock 70 kDa protein
IH404_RS24170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IH404_RS24175	COG0497	DNA recombination
IH404_RS24180	COG0735	belongs to the Fur family
IH404_RS24185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IH404_RS24190	COG2914	Belongs to the UPF0125 (RnfH) family
IH404_RS24200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IH404_RS24205	COG2186	Transcriptional regulator
IH404_RS24210	COG1620	l-lactate permease
IH404_RS24230	COG0582	viral genome integration into host DNA
IH404_RS24280	COG0583	DNA-binding transcription factor activity
IH404_RS24305	COG0351	phosphomethylpyrimidine kinase
IH404_RS24325	COG0583	DNA-binding transcription factor activity
IH404_RS24330	COG0436	Aminotransferase
IH404_RS24365	COG4581	dead DEAH box helicase
IH404_RS24380	COG1335	isochorismatase
IH404_RS24400	COG2862	Uncharacterized protein family, UPF0114
IH404_RS24415	COG1067	ATP-dependent peptidase activity
IH404_RS24445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IH404_RS24455	COG0488	(ABC) transporter
IH404_RS24465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IH404_RS24470	COG0523	cobalamin synthesis protein
IH404_RS24475	COG2879	small protein
IH404_RS24480	COG1966	Carbon starvation protein
IH404_RS24505	COG1970	mechanosensitive ion channel activity
IH404_RS24515	COG2197	response regulator
IH404_RS24520	COG2813	Specifically methylates the guanine in position
IH404_RS24530	COG1294	oxidase, subunit
IH404_RS24535	COG1271	oxidase subunit
IH404_RS24545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IH404_RS24550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IH404_RS24555	COG2080	2 iron, 2 sulfur cluster binding
IH404_RS24565	COG2252	PERMEase
IH404_RS24570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IH404_RS24595	COG1629	transport
IH404_RS24610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IH404_RS24615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IH404_RS24620	COG1309	transcriptional regulator
IH404_RS24625	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IH404_RS24625	COG1082	Xylose isomerase domain protein TIM barrel
IH404_RS24630	COG0477	Major facilitator Superfamily
IH404_RS24645	COG2321	neutral zinc metallopeptidase
IH404_RS24660	COG1946	Acyl-CoA thioesterase
IH404_RS24670	COG0123	including yeast histone deacetylase and acetoin utilization protein
IH404_RS24680	COG0513	Belongs to the DEAD box helicase family
IH404_RS24685	COG0697	spore germination
IH404_RS24690	COG1522	sequence-specific DNA binding
IH404_RS24705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IH404_RS24705	COG1199	ATP-dependent helicase activity
IH404_RS24715	COG3416	Protein conserved in bacteria
IH404_RS24730	COG3622	Belongs to the hyi family
IH404_RS24740	COG4993	Dehydrogenase
IH404_RS24765	COG1643	Atp-dependent helicase
IH404_RS24780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IH404_RS24790	COG1522	sequence-specific DNA binding
IH404_RS24805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IH404_RS24810	COG1960	acyl-CoA dehydrogenase activity
IH404_RS24820	COG0351	phosphomethylpyrimidine kinase
IH404_RS24825	COG0352	thiamine-phosphate diphosphorylase activity
IH404_RS24830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IH404_RS24870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IH404_RS24875	COG1702	phosphate starvation-inducible protein PhoH
IH404_RS24880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IH404_RS24885	COG4535	Mg2 and Co2 transporter CorC
IH404_RS24890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IH404_RS24900	COG0495	leucyl-tRNA aminoacylation
IH404_RS24910	COG1466	dna polymerase III delta subunit
IH404_RS24920	COG2951	lytic endotransglycosylase activity
IH404_RS24925	COG1619	proteins homologs of microcin C7 resistance protein MccF
IH404_RS24930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IH404_RS24935	COG0321	lipoyl(octanoyl) transferase activity
IH404_RS24940	COG2921	Belongs to the UPF0250 family
IH404_RS24945	COG1686	Belongs to the peptidase S11 family
IH404_RS24955	COG2951	lytic endotransglycosylase activity
IH404_RS24960	COG0772	Belongs to the SEDS family
IH404_RS24965	COG0768	penicillin binding
IH404_RS24970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IH404_RS24980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IH404_RS24985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IH404_RS24990	COG2094	Belongs to the DNA glycosylase MPG family
IH404_RS24995	COG0586	Pfam SNARE associated Golgi protein
IH404_RS25010	COG1346	cytolysis
IH404_RS25030	COG0702	epimerase
IH404_RS25045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IH404_RS25055	COG3284	Transcriptional regulator
IH404_RS25065	COG0531	amino acid
IH404_RS25070	COG4303	Ethanolamine ammonia lyase large subunit
IH404_RS25075	COG4302	ethanolamine ammonia-lyase activity
IH404_RS25080	COG0456	acetyltransferase
IH404_RS25085	COG0586	Pfam SNARE associated Golgi protein
IH404_RS25090	COG3228	Belongs to the MtfA family
IH404_RS25095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IH404_RS25115	COG1335	isochorismatase
IH404_RS25125	COG2249	NAD(P)H dehydrogenase (quinone) activity
IH404_RS25135	COG3209	COG3209 Rhs family protein
IH404_RS25145	COG1722	exodeoxyribonuclease VII activity
IH404_RS25150	COG0142	geranyltranstransferase activity
IH404_RS25155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IH404_RS25160	COG4206	TonB-dependent receptor
IH404_RS25175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IH404_RS25185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IH404_RS25190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IH404_RS25195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IH404_RS25210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IH404_RS25210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IH404_RS25215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IH404_RS25225	COG2264	protein methyltransferase activity
IH404_RS25230	COG3118	belongs to the thioredoxin family
IH404_RS25260	COG3047	cAMP biosynthetic process
IH404_RS25270	COG1201	RNA secondary structure unwinding
IH404_RS25275	COG0668	transmembrane transport
IH404_RS25285	COG3568	Endonuclease Exonuclease Phosphatase
IH404_RS25290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IH404_RS25295	COG0392	lysyltransferase activity
IH404_RS25310	COG4753	response regulator
IH404_RS25310	COG2207	Transcriptional regulator
IH404_RS25315	COG1335	isochorismatase
IH404_RS25320	COG4106	trans-aconitate 2-methyltransferase activity
IH404_RS25325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IH404_RS25340	COG1834	amidinotransferase
IH404_RS25350	COG2192	nodulation
IH404_RS25360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IH404_RS25375	COG1280	lysine exporter protein (LysE YggA)
IH404_RS25380	COG0629	single-stranded DNA binding
IH404_RS25385	COG2814	Major facilitator Superfamily
IH404_RS25390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IH404_RS25395	COG2193	ferroxidase activity
IH404_RS25405	COG0203	ribosomal protein L17
IH404_RS25410	COG0202	RNA polymerase activity
IH404_RS25415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IH404_RS25420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IH404_RS25425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IH404_RS25430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IH404_RS25440	COG0200	Binds to the 23S rRNA
IH404_RS25445	COG1841	ribosomal large subunit assembly
IH404_RS25450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IH404_RS25455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IH404_RS25460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IH404_RS25465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IH404_RS25470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IH404_RS25475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IH404_RS25480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IH404_RS25485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IH404_RS25490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IH404_RS25495	COG0255	Belongs to the universal ribosomal protein uL29 family
IH404_RS25500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IH404_RS25505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IH404_RS25510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IH404_RS25515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IH404_RS25520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IH404_RS25525	COG0089	rRNA binding
IH404_RS25530	COG0088	Forms part of the polypeptide exit tunnel
IH404_RS25535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IH404_RS25540	COG0051	transcription antitermination factor activity, RNA binding
IH404_RS25545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IH404_RS25550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IH404_RS25555	COG0049	tRNA binding
IH404_RS25560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IH404_RS25565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IH404_RS25570	COG0085	RNA polymerase activity
IH404_RS25575	COG0222	ribosome binding
IH404_RS25580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IH404_RS25585	COG0081	regulation of translation
IH404_RS25590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IH404_RS25630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IH404_RS25635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IH404_RS25635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IH404_RS25665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IH404_RS25670	COG0739	heme binding
IH404_RS25675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IH404_RS25680	COG0316	Belongs to the HesB IscA family
IH404_RS25685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IH404_RS25690	COG1981	membrane
IH404_RS25705	COG4221	oxidoreductase activity
IH404_RS25710	COG0537	adenosine 5'-monophosphoramidase activity
IH404_RS25715	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IH404_RS25720	COG1765	OsmC-like protein
IH404_RS25735	COG0134	indole-3-glycerol-phosphate synthase activity
IH404_RS25740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IH404_RS25745	COG0512	Glutamine amidotransferase of anthranilate synthase
IH404_RS25750	COG4625	pathogenesis
IH404_RS25750	COG3240	lipase activity
IH404_RS25755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IH404_RS25760	COG0546	phosphoglycolate phosphatase activity
IH404_RS25765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IH404_RS25770	COG1454	alcohol dehydrogenase
IH404_RS25780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IH404_RS25785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IH404_RS25790	COG3178	'Phosphotransferase
IH404_RS25795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IH404_RS25800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IH404_RS25805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IH404_RS25810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IH404_RS25815	COG2967	ApaG domain
IH404_RS25820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IH404_RS25825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IH404_RS25830	COG2766	serine protein kinase
IH404_RS25835	COG2718	Belongs to the UPF0229 family
IH404_RS25840	COG2719	SpoVR family
IH404_RS25845	COG0617	tRNA 3'-terminal CCA addition
IH404_RS25855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IH404_RS25860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IH404_RS25865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IH404_RS25870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IH404_RS25875	COG0358	DNA primase activity
IH404_RS25880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IH404_RS25905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IH404_RS25910	COG1025	Belongs to the peptidase M16 family
IH404_RS25920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IH404_RS25925	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IH404_RS25935	COG0535	radical SAM domain protein
IH404_RS25945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IH404_RS25950	COG0583	DNA-binding transcription factor activity
IH404_RS25955	COG1960	acyl-CoA dehydrogenase activity
IH404_RS25965	COG1960	acyl-CoA dehydrogenase activity
IH404_RS25985	COG2226	methyltransferase
IH404_RS25985	COG1073	alpha beta
IH404_RS25990	COG0156	8-amino-7-oxononanoate synthase activity
IH404_RS25995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IH404_RS26005	COG2005	Transcriptional regulator
IH404_RS26005	COG3585	molybdate ion transport
IH404_RS26015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IH404_RS26030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IH404_RS26040	COG2204	response regulator
IH404_RS26050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IH404_RS26055	COG1595	DNA-templated transcription, initiation
IH404_RS26065	COG4774	siderophore transport
IH404_RS26080	COG0625	glutathione transferase activity
IH404_RS26085	COG4452	Inner membrane protein CreD
IH404_RS26090	COG2205	protein histidine kinase activity
IH404_RS26095	COG0745	RESPONSE REGULATOR receiver
IH404_RS26100	COG0189	ligase activity
IH404_RS26100	COG4067	protein conserved in archaea
IH404_RS26105	COG0204	Acyl-transferase
IH404_RS26145	COG1063	alcohol dehydrogenase
IH404_RS26175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IH404_RS26185	COG0445	tRNA wobble uridine modification
IH404_RS26235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IH404_RS26240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IH404_RS26245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IH404_RS26245	COG1017	nitric oxide dioxygenase activity
IH404_RS26250	COG4638	Rieske (2fe-2S)
IH404_RS26260	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IH404_RS26265	COG0247	lactate metabolic process
IH404_RS26265	COG2181	nitrate reductase activity
IH404_RS26270	COG0446	pyridine nucleotide-disulphide oxidoreductase
IH404_RS26270	COG1902	pentaerythritol trinitrate reductase activity
IH404_RS26290	COG2304	oxidoreductase activity
IH404_RS26315	COG3246	L-lysine catabolic process to acetate
IH404_RS26320	COG1250	3-hydroxyacyl-CoA dehydrogenase
IH404_RS26340	COG1760	l-serine dehydratase
IH404_RS26355	COG4175	Glycine betaine
IH404_RS26360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IH404_RS26365	COG1309	transcriptional regulator
IH404_RS26370	COG1012	belongs to the aldehyde dehydrogenase family
IH404_RS26375	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IH404_RS26395	COG0477	Major facilitator Superfamily
IH404_RS26400	COG0513	Belongs to the DEAD box helicase family
IH404_RS26405	COG2081	HI0933 family
IH404_RS26410	COG1289	transmembrane transporter activity
IH404_RS26420	COG2153	protein acetylation
IH404_RS26430	COG1451	nucleotide metabolic process
IH404_RS26480	COG0126	phosphoglycerate kinase activity
IH404_RS26485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IH404_RS26490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IH404_RS26495	COG0640	Transcriptional regulator
IH404_RS26500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IH404_RS26505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IH404_RS26510	COG1422	Protein of unknown function (DUF1090)
IH404_RS26540	COG2116	formate transmembrane transporter activity
IH404_RS26555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IH404_RS26560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IH404_RS26575	COG0513	Belongs to the DEAD box helicase family
IH404_RS26580	COG2353	YceI-like domain
IH404_RS26585	COG3038	cytochrome b561
IH404_RS26595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IH404_RS26600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS26615	COG1272	protein, Hemolysin III
IH404_RS26635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IH404_RS26655	COG3052	prosthetic group binding
IH404_RS26660	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IH404_RS26675	COG3093	addiction module antidote protein HigA
IH404_RS26690	COG2198	Histidine kinase
IH404_RS26690	COG0643	Histidine kinase
IH404_RS26690	COG0784	Response regulator, receiver
IH404_RS26715	COG0189	ligase activity
IH404_RS26725	COG1678	Uncharacterized ACR, COG1678
IH404_RS26730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IH404_RS26735	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IH404_RS26740	COG0540	Belongs to the ATCase OTCase family
IH404_RS26745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IH404_RS26755	COG0791	NLP P60 protein
IH404_RS26780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IH404_RS26785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IH404_RS26785	COG2813	Specifically methylates the guanine in position
IH404_RS26795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IH404_RS26800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IH404_RS26810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IH404_RS26815	COG2022	thiamine diphosphate biosynthetic process
IH404_RS26820	COG2022	thiamine diphosphate biosynthetic process
IH404_RS26820	COG2104	thiamine diphosphate biosynthetic process
IH404_RS26825	COG2363	Small membrane protein
IH404_RS26830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IH404_RS26840	COG2177	Part of the ABC transporter FtsEX involved in
IH404_RS26845	COG2884	Cell division ATP-binding protein ftsE
IH404_RS26850	COG0552	protein localization to endoplasmic reticulum
IH404_RS26855	COG0612	Peptidase, M16
IH404_RS26860	COG0612	Peptidase, M16
IH404_RS26865	COG0742	ribosomal rna small subunit methyltransferase
IH404_RS26870	COG0429	hydrolase of the alpha beta-hydrolase fold
IH404_RS26880	COG1309	transcriptional regulator
IH404_RS26895	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IH404_RS26900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IH404_RS26905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IH404_RS26910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IH404_RS26920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IH404_RS26925	COG2814	Major facilitator Superfamily
IH404_RS26930	COG0129	dihydroxy-acid dehydratase activity
IH404_RS26955	COG1823	symporter activity
IH404_RS26970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IH404_RS27010	COG1840	ABC-type Fe3 transport system, periplasmic component
IH404_RS27015	COG1178	ABC-type Fe3 transport system permease component
IH404_RS27020	COG3842	ATPase activity
IH404_RS27025	COG0583	DNA-binding transcription factor activity
IH404_RS27035	COG0789	Transcriptional regulator
IH404_RS27040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IH404_RS27045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IH404_RS27055	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IH404_RS27060	COG0494	nUDIX hydrolase
IH404_RS27075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IH404_RS27080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IH404_RS27085	COG2234	aminopeptidase activity
IH404_RS27090	COG3204	pilus organization
IH404_RS27095	COG3204	pilus organization
IH404_RS27100	COG0179	Fumarylacetoacetate (FAA) hydrolase
IH404_RS27105	COG0277	FAD linked oxidase domain protein
IH404_RS27110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IH404_RS27120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS27160	COG1177	transmembrane transport
IH404_RS27165	COG1176	ABC-type spermidine putrescine transport system, permease component I
IH404_RS27170	COG3842	ATPase activity
IH404_RS27190	COG0174	glutamine synthetase
IH404_RS27195	COG0174	glutamine synthetase
IH404_RS27210	COG1116	anion transmembrane transporter activity
IH404_RS27215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IH404_RS27220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IH404_RS27225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IH404_RS27230	COG0431	NADPH-dependent FMN reductase
IH404_RS27235	COG0450	alkyl hydroperoxide reductase
IH404_RS27245	COG4521	taurine ABC transporter
IH404_RS27250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IH404_RS27250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IH404_RS27265	COG1522	sequence-specific DNA binding
IH404_RS27275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IH404_RS27280	COG0330	HflC and HflK could
IH404_RS27295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IH404_RS27300	COG0509	glycine decarboxylation via glycine cleavage system
IH404_RS27305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IH404_RS27310	COG1178	ABC-type Fe3 transport system permease component
IH404_RS27320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IH404_RS27325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IH404_RS27330	COG0006	proline dipeptidase activity
IH404_RS27335	COG3079	Belongs to the UPF0149 family
IH404_RS27355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IH404_RS27370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IH404_RS27375	COG0842	Transport permease protein
IH404_RS27375	COG1129	ABC transporter
IH404_RS27380	COG0842	Transport permease protein
IH404_RS27395	COG2271	Major facilitator Superfamily
IH404_RS27420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IH404_RS27440	COG2186	Transcriptional regulator
IH404_RS27445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IH404_RS27450	COG0765	amino acid transport
IH404_RS27455	COG0765	amino acid transport
IH404_RS27460	COG1126	abc transporter atp-binding protein
IH404_RS27470	COG3188	usher protein
IH404_RS27475	COG3121	Chaperone
IH404_RS27485	COG0248	Ppx GppA phosphatase
IH404_RS27490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IH404_RS27500	COG0586	Pfam SNARE associated Golgi protein
IH404_RS27510	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IH404_RS27515	COG1671	Belongs to the UPF0178 family
IH404_RS27520	COG0672	)-iron permease
IH404_RS27525	COG1280	lysine exporter protein (LysE YggA)
IH404_RS27535	COG0488	(ABC) transporter
IH404_RS27560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IH404_RS27575	COG0181	hydroxymethylbilane synthase activity
IH404_RS27585	COG0165	Argininosuccinate lyase
IH404_RS27590	COG0625	glutathione transferase activity
IH404_RS27610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IH404_RS27620	COG1965	Belongs to the frataxin family
IH404_RS27630	COG0019	diaminopimelate decarboxylase activity
IH404_RS27635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IH404_RS27645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IH404_RS27650	COG1011	Hydrolase
IH404_RS27660	COG0432	Pfam Uncharacterised protein family UPF0047
IH404_RS27665	COG0004	ammonium transporteR
IH404_RS27670	COG0347	Belongs to the P(II) protein family
IH404_RS27680	COG0606	chelatase, subunit chli
IH404_RS27700	COG0583	DNA-binding transcription factor activity
IH404_RS27705	COG0534	Mate efflux family protein