locus-tag	class	description
FXN65_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FXN65_RS00055	COG2818	Glycosylase
FXN65_RS00075	COG1126	abc transporter atp-binding protein
FXN65_RS00080	COG0765	amino acid transport
FXN65_RS00085	COG0765	amino acid transport
FXN65_RS00090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS00095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS00100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FXN65_RS00105	COG2423	ornithine cyclodeaminase activity
FXN65_RS00110	COG0006	proline dipeptidase activity
FXN65_RS00115	COG3608	succinylglutamate desuccinylase aspartoacylase
FXN65_RS00120	COG1522	sequence-specific DNA binding
FXN65_RS00125	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS00130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FXN65_RS00140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN65_RS00145	COG0569	domain protein
FXN65_RS00150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXN65_RS00155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FXN65_RS00160	COG0242	peptide deformylase activity
FXN65_RS00165	COG1652	LysM domain
FXN65_RS00170	COG0758	DNA mediated transformation
FXN65_RS00175	COG0009	L-threonylcarbamoyladenylate synthase
FXN65_RS00190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN65_RS00205	COG3119	arylsulfatase activity
FXN65_RS00210	COG0583	DNA-binding transcription factor activity
FXN65_RS00235	COG0159	tryptophan synthase activity
FXN65_RS00250	COG3360	Dodecin
FXN65_RS00260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXN65_RS00290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FXN65_RS00325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FXN65_RS00325	COG1565	acr, cog1565
FXN65_RS00330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FXN65_RS00335	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FXN65_RS00365	COG0109	protoheme IX farnesyltransferase activity
FXN65_RS00375	COG1464	Belongs to the NlpA lipoprotein family
FXN65_RS00380	COG2011	ABC-type metal ion transport system permease component
FXN65_RS00385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXN65_RS00400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN65_RS00410	COG0735	belongs to the Fur family
FXN65_RS00415	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FXN65_RS00445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FXN65_RS00475	COG0415	Belongs to the DNA photolyase family
FXN65_RS00480	COG2095	MarC family integral membrane protein
FXN65_RS00485	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXN65_RS00490	COG5002	protein histidine kinase activity
FXN65_RS00495	COG2204	response regulator
FXN65_RS00515	COG0655	NAD(P)H dehydrogenase (quinone) activity
FXN65_RS00520	COG1301	dicarboxylic acid transport
FXN65_RS00525	COG0700	Nucleoside recognition
FXN65_RS00560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN65_RS00575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FXN65_RS00580	COG1074	ATP-dependent DNA helicase activity
FXN65_RS00585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN65_RS00595	COG0861	Integral membrane protein TerC family
FXN65_RS00600	COG2851	Citrate transporter
FXN65_RS00605	COG0679	Auxin Efflux Carrier
FXN65_RS00640	COG0427	acetyl-CoA hydrolase
FXN65_RS00660	COG2197	response regulator
FXN65_RS00675	COG0583	DNA-binding transcription factor activity
FXN65_RS00680	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS00685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS00720	COG0252	asparaginase activity
FXN65_RS00750	COG1639	'signal transduction protein
FXN65_RS00765	COG4221	oxidoreductase activity
FXN65_RS00840	COG4208	sulfate ABC transporter
FXN65_RS00850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FXN65_RS00855	COG5583	Uncharacterized small protein (DUF2292)
FXN65_RS00885	COG1566	PFAM secretion protein HlyD family protein
FXN65_RS00895	COG3706	GGDEF domain
FXN65_RS00915	COG2814	Major facilitator Superfamily
FXN65_RS00925	COG3609	addiction module antidote protein, CC2985 family
FXN65_RS00940	COG1126	abc transporter atp-binding protein
FXN65_RS00945	COG0765	amino acid transport
FXN65_RS00950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS00955	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FXN65_RS00965	COG0626	cystathionine gamma-synthase activity
FXN65_RS00970	COG2188	Transcriptional regulator
FXN65_RS00975	COG1053	succinate dehydrogenase
FXN65_RS00990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXN65_RS01010	COG1297	OPT oligopeptide transporter protein
FXN65_RS01015	COG2175	clavaminate synthase activity
FXN65_RS01020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXN65_RS01025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FXN65_RS01030	COG4521	taurine ABC transporter
FXN65_RS01040	COG0450	alkyl hydroperoxide reductase
FXN65_RS01045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXN65_RS01050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXN65_RS01055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXN65_RS01070	COG2957	Belongs to the agmatine deiminase family
FXN65_RS01090	COG0174	glutamine synthetase
FXN65_RS01095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FXN65_RS01100	COG0174	glutamine synthetase
FXN65_RS01120	COG3842	ATPase activity
FXN65_RS01125	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS01130	COG1177	transmembrane transport
FXN65_RS01140	COG0730	response to heat
FXN65_RS01145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FXN65_RS01150	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FXN65_RS01155	COG3719	Belongs to the RNase T2 family
FXN65_RS01165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FXN65_RS01175	COG2233	PERMEase
FXN65_RS01190	COG2233	PERMEase
FXN65_RS01200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXN65_RS01210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FXN65_RS01230	COG0405	Gamma-glutamyltransferase
FXN65_RS01235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN65_RS01245	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FXN65_RS01285	COG0429	hydrolase of the alpha beta-hydrolase fold
FXN65_RS01290	COG0742	ribosomal rna small subunit methyltransferase
FXN65_RS01295	COG0612	Peptidase, M16
FXN65_RS01300	COG0612	Peptidase, M16
FXN65_RS01305	COG0552	protein localization to endoplasmic reticulum
FXN65_RS01310	COG2884	Cell division ATP-binding protein ftsE
FXN65_RS01315	COG2177	Part of the ABC transporter FtsEX involved in
FXN65_RS01330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN65_RS01335	COG2363	Small membrane protein
FXN65_RS01345	COG2022	thiamine diphosphate biosynthetic process
FXN65_RS01350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FXN65_RS01370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN65_RS01375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXN65_RS01385	COG2813	Specifically methylates the guanine in position
FXN65_RS01385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN65_RS01390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN65_RS01395	COG1160	GTP binding
FXN65_RS01400	COG1872	DUF167
FXN65_RS01440	COG0626	cystathionine gamma-synthase activity
FXN65_RS01480	COG1683	Conserved Protein
FXN65_RS01485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS01495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXN65_RS01500	COG0277	FAD linked oxidase domain protein
FXN65_RS01505	COG0179	Fumarylacetoacetate (FAA) hydrolase
FXN65_RS01510	COG3204	pilus organization
FXN65_RS01515	COG3111	PFAM Bacterial OB fold (BOF) protein
FXN65_RS01525	COG0531	amino acid
FXN65_RS01535	COG1177	transmembrane transport
FXN65_RS01540	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS01545	COG3842	ATPase activity
FXN65_RS01565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXN65_RS01570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FXN65_RS01590	COG0494	nUDIX hydrolase
FXN65_RS01595	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
FXN65_RS01610	COG0540	Belongs to the ATCase OTCase family
FXN65_RS01665	COG0643	Histidine kinase
FXN65_RS01665	COG0784	Response regulator, receiver
FXN65_RS01665	COG2198	Histidine kinase
FXN65_RS01670	COG2201	protein-glutamate methylesterase activity
FXN65_RS01680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FXN65_RS01695	COG3038	cytochrome b561
FXN65_RS01700	COG2353	YceI-like domain
FXN65_RS01705	COG0513	Belongs to the DEAD box helicase family
FXN65_RS01715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXN65_RS01740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FXN65_RS01750	COG0640	Transcriptional regulator
FXN65_RS01770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN65_RS01775	COG0126	phosphoglycerate kinase activity
FXN65_RS01805	COG1451	nucleotide metabolic process
FXN65_RS01830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS01840	COG1289	transmembrane transporter activity
FXN65_RS01845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS01850	COG0513	Belongs to the DEAD box helicase family
FXN65_RS01855	COG1879	ABC-type sugar transport system periplasmic component
FXN65_RS01875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXN65_RS01900	COG4175	Glycine betaine
FXN65_RS01910	COG1760	l-serine dehydratase
FXN65_RS01930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FXN65_RS01935	COG2181	nitrate reductase activity
FXN65_RS01935	COG0247	lactate metabolic process
FXN65_RS01940	COG1902	pentaerythritol trinitrate reductase activity
FXN65_RS01940	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXN65_RS01970	COG3383	formate dehydrogenase (NAD+) activity
FXN65_RS01990	COG3246	L-lysine catabolic process to acetate
FXN65_RS02000	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXN65_RS02000	COG0824	Thioesterase
FXN65_RS02005	COG2197	response regulator
FXN65_RS02010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS02010	COG2205	protein histidine kinase activity
FXN65_RS02015	COG2199	diguanylate cyclase activity
FXN65_RS02015	COG2200	EAL domain
FXN65_RS02015	COG2202	Pas domain
FXN65_RS02020	COG2197	response regulator
FXN65_RS02025	COG3539	Fimbrial protein
FXN65_RS02030	COG3121	Chaperone
FXN65_RS02035	COG3188	usher protein
FXN65_RS02060	COG1017	nitric oxide dioxygenase activity
FXN65_RS02060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXN65_RS02065	COG0625	glutathione transferase activity
FXN65_RS02095	COG1760	l-serine dehydratase
FXN65_RS02110	COG0477	Major facilitator Superfamily
FXN65_RS02160	COG1063	alcohol dehydrogenase
FXN65_RS02170	COG0204	Acyl-transferase
FXN65_RS02180	COG0745	RESPONSE REGULATOR receiver
FXN65_RS02185	COG2205	protein histidine kinase activity
FXN65_RS02190	COG0617	tRNA 3'-terminal CCA addition
FXN65_RS02190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FXN65_RS02190	COG0517	IMP dehydrogenase activity
FXN65_RS02195	COG4452	Inner membrane protein CreD
FXN65_RS02205	COG0625	glutathione transferase activity
FXN65_RS02225	COG0745	RESPONSE REGULATOR receiver
FXN65_RS02230	COG1953	Uracil, thiamine, allantoin
FXN65_RS02255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FXN65_RS02260	COG2005	Transcriptional regulator
FXN65_RS02260	COG3585	molybdate ion transport
FXN65_RS02265	COG1040	competence protein
FXN65_RS02280	COG0156	8-amino-7-oxononanoate synthase activity
FXN65_RS02285	COG2226	methyltransferase
FXN65_RS02285	COG1073	alpha beta
FXN65_RS02305	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS02315	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS02320	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS02330	COG0583	DNA-binding transcription factor activity
FXN65_RS02335	COG2258	MOSC domain
FXN65_RS02345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FXN65_RS02355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXN65_RS02400	COG0583	DNA-binding transcription factor activity
FXN65_RS02405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS02415	COG0174	glutamine synthetase
FXN65_RS02425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS02430	COG0010	Belongs to the arginase family
FXN65_RS02450	COG0583	DNA-binding transcription factor activity
FXN65_RS02455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXN65_RS02460	COG0402	S-adenosylhomocysteine deaminase activity
FXN65_RS02475	COG1177	transmembrane transport
FXN65_RS02480	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS02485	COG3842	ATPase activity
FXN65_RS02515	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
FXN65_RS02535	COG0358	DNA primase activity
FXN65_RS02565	COG0617	tRNA 3'-terminal CCA addition
FXN65_RS02575	COG2719	SpoVR family
FXN65_RS02580	COG2718	Belongs to the UPF0229 family
FXN65_RS02585	COG2766	serine protein kinase
FXN65_RS02590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN65_RS02595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXN65_RS02600	COG2967	ApaG domain
FXN65_RS02605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXN65_RS02610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FXN65_RS02620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXN65_RS02630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FXN65_RS02635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FXN65_RS02650	COG2197	response regulator
FXN65_RS02655	COG3842	ATPase activity
FXN65_RS02665	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS02685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXN65_RS02690	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN65_RS02710	COG1765	OsmC-like protein
FXN65_RS02720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FXN65_RS02725	COG0537	adenosine 5'-monophosphoramidase activity
FXN65_RS02755	COG1981	membrane
FXN65_RS02765	COG0316	Belongs to the HesB IscA family
FXN65_RS02770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FXN65_RS02775	COG0739	heme binding
FXN65_RS02780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FXN65_RS02820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FXN65_RS02865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FXN65_RS02875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXN65_RS02885	COG0085	RNA polymerase activity
FXN65_RS02890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FXN65_RS02895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXN65_RS02900	COG0049	tRNA binding
FXN65_RS02905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FXN65_RS02915	COG0051	transcription antitermination factor activity, RNA binding
FXN65_RS02920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXN65_RS02925	COG0088	Forms part of the polypeptide exit tunnel
FXN65_RS02935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXN65_RS02945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FXN65_RS02950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXN65_RS02965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXN65_RS02970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FXN65_RS02975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FXN65_RS02985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FXN65_RS02990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXN65_RS03005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FXN65_RS03015	COG0200	Binds to the 23S rRNA
FXN65_RS03030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FXN65_RS03040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXN65_RS03050	COG0203	ribosomal protein L17
FXN65_RS03055	COG0753	catalase activity
FXN65_RS03065	COG2814	Major facilitator Superfamily
FXN65_RS03085	COG1595	DNA-templated transcription, initiation
FXN65_RS03105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXN65_RS03150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXN65_RS03190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN65_RS03195	COG3047	cAMP biosynthetic process
FXN65_RS03210	COG4181	ATPase activity
FXN65_RS03225	COG3118	belongs to the thioredoxin family
FXN65_RS03230	COG2264	protein methyltransferase activity
FXN65_RS03245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN65_RS03245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN65_RS03260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXN65_RS03275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FXN65_RS03285	COG3577	Aspartyl protease
FXN65_RS03290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN65_RS03300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXN65_RS03305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FXN65_RS03310	COG2267	carboxylic ester hydrolase activity
FXN65_RS03315	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FXN65_RS03330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN65_RS03345	COG0765	amino acid transport
FXN65_RS03350	COG0765	amino acid transport
FXN65_RS03360	COG2207	Transcriptional regulator
FXN65_RS03360	COG1917	Cupin 2, conserved barrel domain protein
FXN65_RS03375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS03385	COG0142	geranyltranstransferase activity
FXN65_RS03390	COG1722	exodeoxyribonuclease VII activity
FXN65_RS03395	COG0730	response to heat
FXN65_RS03445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXN65_RS03465	COG3228	Belongs to the MtfA family
FXN65_RS03470	COG0586	Pfam SNARE associated Golgi protein
FXN65_RS03475	COG0456	acetyltransferase
FXN65_RS03485	COG4302	ethanolamine ammonia-lyase activity
FXN65_RS03490	COG4303	Ethanolamine ammonia lyase large subunit
FXN65_RS03510	COG3284	Transcriptional regulator
FXN65_RS03525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FXN65_RS03535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXN65_RS03550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXN65_RS03555	COG0702	epimerase
FXN65_RS03575	COG1346	cytolysis
FXN65_RS03585	COG0586	Pfam SNARE associated Golgi protein
FXN65_RS03610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FXN65_RS03625	COG0768	penicillin binding
FXN65_RS03630	COG0772	Belongs to the SEDS family
FXN65_RS03635	COG2951	lytic endotransglycosylase activity
FXN65_RS03645	COG1686	Belongs to the peptidase S11 family
FXN65_RS03655	COG0321	lipoyl(octanoyl) transferase activity
FXN65_RS03660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FXN65_RS03665	COG2951	lytic endotransglycosylase activity
FXN65_RS03685	COG0495	leucyl-tRNA aminoacylation
FXN65_RS03695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FXN65_RS03700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FXN65_RS03705	COG4535	Mg2 and Co2 transporter CorC
FXN65_RS03710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXN65_RS03715	COG1702	phosphate starvation-inducible protein PhoH
FXN65_RS03740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXN65_RS03750	COG0351	phosphomethylpyrimidine kinase
FXN65_RS03765	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS03775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FXN65_RS03795	COG1522	sequence-specific DNA binding
FXN65_RS03805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FXN65_RS03810	COG2318	DinB family
FXN65_RS03820	COG1643	Atp-dependent helicase
FXN65_RS03860	COG1335	isochorismatase
FXN65_RS03875	COG1522	sequence-specific DNA binding
FXN65_RS03880	COG0697	spore germination
FXN65_RS03885	COG0513	Belongs to the DEAD box helicase family
FXN65_RS03895	COG3842	ATPase activity
FXN65_RS03900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS03910	COG1177	transmembrane transport
FXN65_RS03915	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS03935	COG0123	including yeast histone deacetylase and acetoin utilization protein
FXN65_RS03950	COG1946	Acyl-CoA thioesterase
FXN65_RS03960	COG2852	Protein conserved in bacteria
FXN65_RS03965	COG2321	neutral zinc metallopeptidase
FXN65_RS03995	COG2252	PERMEase
FXN65_RS04000	COG0693	protein deglycase activity
FXN65_RS04035	COG1271	oxidase subunit
FXN65_RS04040	COG1294	oxidase, subunit
FXN65_RS04065	COG3278	Belongs to the heme-copper respiratory oxidase family
FXN65_RS04080	COG1253	flavin adenine dinucleotide binding
FXN65_RS04125	COG1966	Carbon starvation protein
FXN65_RS04130	COG2879	small protein
FXN65_RS04150	COG0488	(ABC) transporter
FXN65_RS04170	COG1690	Belongs to the RtcB family
FXN65_RS04185	COG1067	ATP-dependent peptidase activity
FXN65_RS04195	COG2862	Uncharacterized protein family, UPF0114
FXN65_RS04205	COG0545	Peptidyl-prolyl cis-trans isomerase
FXN65_RS04210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXN65_RS04215	COG0142	geranyltranstransferase activity
FXN65_RS04220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FXN65_RS04235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FXN65_RS04240	COG3045	CreA protein
FXN65_RS04255	COG0196	riboflavin kinase activity
FXN65_RS04270	COG1047	Peptidyl-prolyl cis-trans
FXN65_RS04275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FXN65_RS04310	COG4969	Belongs to the N-Me-Phe pilin family
FXN65_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS04340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FXN65_RS04340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXN65_RS04390	COG1252	NADH dehydrogenase
FXN65_RS04430	COG0237	dephospho-CoA kinase activity
FXN65_RS04435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FXN65_RS04450	COG4969	Belongs to the N-Me-Phe pilin family
FXN65_RS04455	COG3307	-O-antigen
FXN65_RS04485	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXN65_RS04500	COG0084	hydrolase, TatD family'
FXN65_RS04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS04525	COG1309	transcriptional regulator
FXN65_RS04540	COG0019	diaminopimelate decarboxylase activity
FXN65_RS04545	COG4774	siderophore transport
FXN65_RS04555	COG4774	siderophore transport
FXN65_RS04560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FXN65_RS04575	COG1984	allophanate hydrolase subunit 2
FXN65_RS04590	COG4608	Belongs to the ABC transporter superfamily
FXN65_RS04595	COG0444	Belongs to the ABC transporter superfamily
FXN65_RS04600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXN65_RS04605	COG0601	transmembrane transport
FXN65_RS04610	COG0747	negative chemotaxis
FXN65_RS04625	COG0747	negative chemotaxis
FXN65_RS04630	COG0747	negative chemotaxis
FXN65_RS04645	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FXN65_RS04655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN65_RS04660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN65_RS04665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FXN65_RS04675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FXN65_RS04680	COG1077	Cell shape determining protein MreB Mrl
FXN65_RS04685	COG1792	Involved in formation and maintenance of cell shape
FXN65_RS04710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXN65_RS04715	COG0312	modulator of DNA gyrase
FXN65_RS04720	COG3028	Belongs to the UPF0307 family
FXN65_RS04725	COG0312	modulator of DNA gyrase
FXN65_RS04735	COG1660	Displays ATPase and GTPase activities
FXN65_RS04750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FXN65_RS04755	COG1137	ATPase activity
FXN65_RS04770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FXN65_RS04780	COG1127	ABC transporter
FXN65_RS04785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXN65_RS04790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FXN65_RS04815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FXN65_RS04820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FXN65_RS04825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXN65_RS04840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN65_RS04850	COG2951	lytic endotransglycosylase activity
FXN65_RS04880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FXN65_RS04895	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS04900	COG0667	Aldo Keto reductase
FXN65_RS04905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FXN65_RS04910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FXN65_RS04915	COG0723	plastoquinol--plastocyanin reductase activity
FXN65_RS04920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FXN65_RS04925	COG2857	Cytochrome c1
FXN65_RS04930	COG0625	glutathione transferase activity
FXN65_RS04935	COG2969	positive regulation of protein catabolic process
FXN65_RS04940	COG2823	Periplasmic or secreted lipoprotein
FXN65_RS04955	COG3107	peptidoglycan biosynthetic process
FXN65_RS04990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FXN65_RS04995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXN65_RS05000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXN65_RS05005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXN65_RS05010	COG0772	Belongs to the SEDS family
FXN65_RS05015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXN65_RS05020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXN65_RS05025	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXN65_RS05045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FXN65_RS05060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FXN65_RS05070	COG0494	nUDIX hydrolase
FXN65_RS05075	COG2096	Adenosyltransferase
FXN65_RS05090	COG0745	RESPONSE REGULATOR receiver
FXN65_RS05095	COG1666	GTP binding
FXN65_RS05100	COG0668	transmembrane transport
FXN65_RS05105	COG2211	Major facilitator Superfamily
FXN65_RS05160	COG3081	Nucleoid-associated protein
FXN65_RS05170	COG0420	3'-5' exonuclease activity
FXN65_RS05175	COG0419	ATPase involved in DNA repair
FXN65_RS05180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FXN65_RS05190	COG0490	domain, Protein
FXN65_RS05190	COG0471	metal ion transport
FXN65_RS05220	COG0795	lipopolysaccharide-transporting ATPase activity
FXN65_RS05225	COG0795	lipopolysaccharide-transporting ATPase activity
FXN65_RS05235	COG1278	Cold shock
FXN65_RS05245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FXN65_RS05255	COG1862	Preprotein translocase
FXN65_RS05270	COG3134	Outer membrane lipoprotein
FXN65_RS05285	COG1045	serine acetyltransferase
FXN65_RS05305	COG0316	Belongs to the HesB IscA family
FXN65_RS05350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FXN65_RS05370	COG1160	GTP binding
FXN65_RS05375	COG0436	Aminotransferase
FXN65_RS05385	COG1733	regulation of RNA biosynthetic process
FXN65_RS05395	COG0668	transmembrane transport
FXN65_RS05400	COG0739	heme binding
FXN65_RS05405	COG1570	exodeoxyribonuclease VII activity
FXN65_RS05435	COG0590	tRNA wobble adenosine to inosine editing
FXN65_RS05470	COG0697	spore germination
FXN65_RS05490	COG0300	oxidoreductase activity
FXN65_RS05560	COG3022	response to hydroperoxide
FXN65_RS05565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FXN65_RS05570	COG0315	cyclic pyranopterin monophosphate synthase activity
FXN65_RS05575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FXN65_RS05590	COG1126	abc transporter atp-binding protein
FXN65_RS05595	COG0765	amino acid transport
FXN65_RS05600	COG4597	amino acid ABC transporter
FXN65_RS05605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS05610	COG0400	carboxylic ester hydrolase activity
FXN65_RS05615	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS05620	COG3706	GGDEF domain
FXN65_RS05640	COG0714	Associated with various cellular activities
FXN65_RS05665	COG2925	Exonuclease
FXN65_RS05675	COG0788	formyltetrahydrofolate deformylase activity
FXN65_RS05680	COG0617	tRNA 3'-terminal CCA addition
FXN65_RS05680	COG0517	IMP dehydrogenase activity
FXN65_RS05680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FXN65_RS05690	COG0433	COG0433 Predicted ATPase
FXN65_RS05695	COG0306	phosphate transporter
FXN65_RS05705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS05710	COG0348	domain, Protein
FXN65_RS05715	COG0494	nUDIX hydrolase
FXN65_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS05750	COG0657	acetylesterase activity
FXN65_RS05755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN65_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS05785	COG1053	succinate dehydrogenase
FXN65_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS05810	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS05850	COG1686	Belongs to the peptidase S11 family
FXN65_RS05855	COG0583	DNA-binding transcription factor activity
FXN65_RS05865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FXN65_RS05870	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS05900	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FXN65_RS05915	COG2076	Multidrug Resistance protein
FXN65_RS05950	COG3339	Conserved Protein
FXN65_RS05975	COG2199	diguanylate cyclase activity
FXN65_RS05975	COG2200	EAL domain
FXN65_RS05985	COG0604	alcohol dehydrogenase
FXN65_RS05985	COG4221	oxidoreductase activity
FXN65_RS05985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FXN65_RS05985	COG3321	synthase
FXN65_RS06015	COG3842	ATPase activity
FXN65_RS06025	COG0395	ABC-type sugar transport system, permease component
FXN65_RS06045	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXN65_RS06050	COG1362	aminopeptidase activity
FXN65_RS06060	COG0564	pseudouridine synthase activity
FXN65_RS06065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FXN65_RS06070	COG2894	cell division
FXN65_RS06075	COG0850	regulation of cytokinetic process
FXN65_RS06080	COG1560	Kdo2-lipid A biosynthetic process
FXN65_RS06095	COG2853	Lipoprotein
FXN65_RS06120	COG3162	membrane
FXN65_RS06125	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN65_RS06155	COG1742	UPF0060 membrane protein
FXN65_RS06160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXN65_RS06175	COG3089	Belongs to the UPF0270 family
FXN65_RS06180	COG2205	protein histidine kinase activity
FXN65_RS06180	COG5002	protein histidine kinase activity
FXN65_RS06180	COG0784	Response regulator, receiver
FXN65_RS06185	COG1363	Peptidase, m42
FXN65_RS06190	COG0189	ligase activity
FXN65_RS06190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FXN65_RS06205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FXN65_RS06205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS06215	COG0183	Belongs to the thiolase family
FXN65_RS06225	COG0697	spore germination
FXN65_RS06230	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN65_RS06250	COG0271	Belongs to the BolA IbaG family
FXN65_RS06255	COG1054	Belongs to the UPF0176 family
FXN65_RS06265	COG1132	(ABC) transporter
FXN65_RS06280	COG0625	glutathione transferase activity
FXN65_RS06285	COG1113	amino acid transport
FXN65_RS06300	COG0346	lactoylglutathione lyase activity
FXN65_RS06315	COG1024	Enoyl-CoA hydratase
FXN65_RS06325	COG1024	Enoyl-CoA hydratase
FXN65_RS06330	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS06335	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS06340	COG0183	Belongs to the thiolase family
FXN65_RS06345	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS06355	COG0596	Alpha beta hydrolase
FXN65_RS06370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS06375	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS06380	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS06395	COG0183	Belongs to the thiolase family
FXN65_RS06440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FXN65_RS06450	COG0840	transmembrane signaling receptor activity
FXN65_RS06460	COG0643	Histidine kinase
FXN65_RS06460	COG2198	Histidine kinase
FXN65_RS06465	COG0745	RESPONSE REGULATOR receiver
FXN65_RS06470	COG0840	transmembrane signaling receptor activity
FXN65_RS06480	COG1846	Transcriptional regulator
FXN65_RS06505	COG1335	isochorismatase
FXN65_RS06510	COG1335	isochorismatase
FXN65_RS06520	COG0583	DNA-binding transcription factor activity
FXN65_RS06525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FXN65_RS06535	COG1335	isochorismatase
FXN65_RS06540	COG0583	DNA-binding transcription factor activity
FXN65_RS06545	COG2326	polyphosphate kinase activity
FXN65_RS06550	COG0741	lytic transglycosylase activity
FXN65_RS06555	COG0393	Putative heavy-metal-binding
FXN65_RS06560	COG1764	response to oxidative stress
FXN65_RS06585	COG1653	transport
FXN65_RS06590	COG1175	transmembrane transport
FXN65_RS06600	COG3842	ATPase activity
FXN65_RS06605	COG4580	involved in the transport of maltose and maltodextrins
FXN65_RS06615	COG1737	Transcriptional regulator
FXN65_RS06630	COG0800	Aldolase
FXN65_RS06635	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS06640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN65_RS06660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FXN65_RS06670	COG0411	ABC transporter
FXN65_RS06685	COG0154	amidase activity
FXN65_RS06705	COG4638	Rieske (2fe-2S)
FXN65_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS06725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXN65_RS06745	COG4948	Mandelate Racemase Muconate Lactonizing
FXN65_RS06750	COG4829	muconolactone delta-isomerase
FXN65_RS06755	COG3485	protocatechuate 3,4-dioxygenase
FXN65_RS06775	COG1129	ABC transporter
FXN65_RS06795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXN65_RS06795	COG0543	2 iron, 2 sulfur cluster binding
FXN65_RS06800	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FXN65_RS06805	COG4638	Rieske (2fe-2S)
FXN65_RS06820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN65_RS06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS06830	COG2814	Major facilitator Superfamily
FXN65_RS06875	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FXN65_RS06920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN65_RS06935	COG0174	glutamine synthetase
FXN65_RS06940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS06950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXN65_RS06975	COG4657	Part of a membrane complex involved in electron transport
FXN65_RS06985	COG0489	protein tyrosine kinase activity
FXN65_RS06995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FXN65_RS07000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FXN65_RS07010	COG0625	glutathione transferase activity
FXN65_RS07015	COG0653	protein targeting
FXN65_RS07030	COG3012	SEC-C Motif Domain Protein
FXN65_RS07065	COG1199	ATP-dependent helicase activity
FXN65_RS07085	COG0259	pyridoxamine-phosphate oxidase activity
FXN65_RS07100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FXN65_RS07100	COG2111	Na H antiporter
FXN65_RS07105	COG1006	Multisubunit Na H antiporter MnhC subunit
FXN65_RS07110	COG0651	ATP synthesis coupled electron transport
FXN65_RS07115	COG1863	multisubunit Na H antiporter MnhE subunit
FXN65_RS07120	COG2212	antiporter activity
FXN65_RS07135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN65_RS07145	COG3189	MarR family transcriptional regulator
FXN65_RS07160	COG0537	adenosine 5'-monophosphoramidase activity
FXN65_RS07195	COG2154	pterin-4-alpha-carbinolamine dehydratase
FXN65_RS07220	COG1024	Enoyl-CoA hydratase
FXN65_RS07255	COG3180	Ammonia monooxygenase
FXN65_RS07300	COG0354	folic acid binding
FXN65_RS07335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN65_RS07340	COG0481	GTPase activity
FXN65_RS07355	COG0571	ribonuclease III activity
FXN65_RS07360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FXN65_RS07370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FXN65_RS07375	COG2076	Multidrug Resistance protein
FXN65_RS07385	COG0583	DNA-binding transcription factor activity
FXN65_RS07390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXN65_RS07395	COG2076	Multidrug Resistance protein
FXN65_RS07410	COG1113	amino acid transport
FXN65_RS07425	COG0656	L-ascorbic acid biosynthetic process
FXN65_RS07500	COG2132	Multicopper oxidase
FXN65_RS07505	COG3064	Membrane
FXN65_RS07540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN65_RS07550	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS07555	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS07560	COG0069	glutamate synthase activity
FXN65_RS07610	COG3639	organic phosphonate transmembrane transporter activity
FXN65_RS07620	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FXN65_RS07625	COG2084	Dehydrogenase
FXN65_RS07630	COG3622	Belongs to the hyi family
FXN65_RS07640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FXN65_RS07650	COG2271	Major facilitator Superfamily
FXN65_RS07655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXN65_RS07685	COG1132	(ABC) transporter
FXN65_RS07695	COG2267	carboxylic ester hydrolase activity
FXN65_RS07710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXN65_RS07725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FXN65_RS07730	COG0513	Belongs to the DEAD box helicase family
FXN65_RS07760	COG2996	Protein conserved in bacteria
FXN65_RS07780	COG0697	spore germination
FXN65_RS07785	COG0583	DNA-binding transcription factor activity
FXN65_RS07800	COG1278	Cold shock
FXN65_RS07810	COG0583	DNA-binding transcription factor activity
FXN65_RS07840	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN65_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS07865	COG5265	(ABC) transporter
FXN65_RS07870	COG0583	DNA-binding transcription factor activity
FXN65_RS07875	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FXN65_RS07885	COG1522	sequence-specific DNA binding
FXN65_RS07900	COG0217	transcriptional regulatory protein
FXN65_RS07905	COG1881	PFAM PEBP family protein
FXN65_RS07915	COG3706	GGDEF domain
FXN65_RS07920	COG4977	sequence-specific DNA binding
FXN65_RS07925	COG1335	isochorismatase
FXN65_RS07940	COG2264	protein methyltransferase activity
FXN65_RS07945	COG1335	isochorismatase
FXN65_RS07950	COG0243	molybdopterin cofactor binding
FXN65_RS07955	COG2146	nitrite reductase [NAD(P)H] activity
FXN65_RS07955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXN65_RS07975	COG2197	response regulator
FXN65_RS08000	COG1566	PFAM secretion protein HlyD family protein
FXN65_RS08010	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXN65_RS08025	COG0745	RESPONSE REGULATOR receiver
FXN65_RS08050	COG3829	transcription factor binding
FXN65_RS08065	COG0431	NADPH-dependent FMN reductase
FXN65_RS08090	COG0477	Major facilitator Superfamily
FXN65_RS08100	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
FXN65_RS08120	COG0784	Response regulator, receiver
FXN65_RS08120	COG0835	chemotaxis
FXN65_RS08125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FXN65_RS08130	COG1764	response to oxidative stress
FXN65_RS08145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS08170	COG0833	amino acid
FXN65_RS08175	COG1024	Enoyl-CoA hydratase
FXN65_RS08180	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS08200	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN65_RS08205	COG1815	bacterial-type flagellum-dependent cell motility
FXN65_RS08215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FXN65_RS08225	COG4787	bacterial-type flagellum-dependent cell motility
FXN65_RS08275	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FXN65_RS08295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FXN65_RS08320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FXN65_RS08330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FXN65_RS08335	COG1516	flagellar protein fliS
FXN65_RS08390	COG2882	bacterial-type flagellum organization
FXN65_RS08400	COG0745	RESPONSE REGULATOR receiver
FXN65_RS08440	COG1987	bacterial-type flagellum assembly
FXN65_RS08455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FXN65_RS08485	COG2198	Histidine kinase
FXN65_RS08485	COG0784	Response regulator, receiver
FXN65_RS08485	COG0643	Histidine kinase
FXN65_RS08490	COG2201	protein-glutamate methylesterase activity
FXN65_RS08495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FXN65_RS08500	COG1360	Flagellar Motor Protein
FXN65_RS08505	COG1192	Involved in chromosome partitioning
FXN65_RS08515	COG0835	chemotaxis
FXN65_RS08545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FXN65_RS08575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FXN65_RS08630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FXN65_RS08635	COG1752	Esterase of the alpha-beta hydrolase superfamily
FXN65_RS08645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN65_RS08655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN65_RS08690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN65_RS08695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN65_RS08700	COG0778	Nitroreductase
FXN65_RS08715	COG0745	RESPONSE REGULATOR receiver
FXN65_RS08725	COG2350	Protein conserved in bacteria
FXN65_RS08730	COG2917	probably involved in intracellular septation
FXN65_RS08735	COG0613	PHP domain protein
FXN65_RS08740	COG0009	L-threonylcarbamoyladenylate synthase
FXN65_RS08755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FXN65_RS08770	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS08775	COG0546	phosphoglycolate phosphatase activity
FXN65_RS08780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FXN65_RS08785	COG0402	S-adenosylhomocysteine deaminase activity
FXN65_RS08790	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FXN65_RS08800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FXN65_RS08815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXN65_RS08825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXN65_RS08830	COG0477	Major facilitator Superfamily
FXN65_RS08845	COG0583	DNA-binding transcription factor activity
FXN65_RS08850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXN65_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS08880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXN65_RS08900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FXN65_RS08910	COG4221	oxidoreductase activity
FXN65_RS08930	COG0786	glutamate:sodium symporter activity
FXN65_RS08935	COG0583	DNA-binding transcription factor activity
FXN65_RS08940	COG0673	inositol 2-dehydrogenase activity
FXN65_RS08950	COG2169	Transcriptional regulator
FXN65_RS08950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXN65_RS08965	COG0531	amino acid
FXN65_RS08975	COG1230	cation diffusion facilitator family transporter
FXN65_RS08985	COG2186	Transcriptional regulator
FXN65_RS08990	COG2807	transmembrane transport
FXN65_RS08995	COG0583	DNA-binding transcription factor activity
FXN65_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS09025	COG1126	abc transporter atp-binding protein
FXN65_RS09030	COG0765	amino acid transport
FXN65_RS09035	COG0765	amino acid transport
FXN65_RS09080	COG2072	flavoprotein involved in K transport
FXN65_RS09130	COG0438	transferase activity, transferring glycosyl groups
FXN65_RS09145	COG1086	Polysaccharide biosynthesis protein
FXN65_RS09160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXN65_RS09170	COG1555	photosystem II stabilization
FXN65_RS09190	COG0697	spore germination
FXN65_RS09205	COG0583	DNA-binding transcription factor activity
FXN65_RS09210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXN65_RS09255	COG0800	Aldolase
FXN65_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS09295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FXN65_RS09300	COG0066	3-isopropylmalate dehydratase activity
FXN65_RS09305	COG2226	methyltransferase
FXN65_RS09335	COG0135	phosphoribosylanthranilate isomerase activity
FXN65_RS09345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FXN65_RS09350	COG0285	dihydrofolate synthase activity
FXN65_RS09360	COG1286	toxin biosynthetic process
FXN65_RS09460	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXN65_RS09460	COG1902	pentaerythritol trinitrate reductase activity
FXN65_RS09475	COG0425	Belongs to the sulfur carrier protein TusA family
FXN65_RS09475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN65_RS09500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FXN65_RS09505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXN65_RS09515	COG3139	Protein of unknown function (DUF1315)
FXN65_RS09525	COG0308	aminopeptidase N
FXN65_RS09575	COG0714	Associated with various cellular activities
FXN65_RS09600	COG3130	regulation of translation
FXN65_RS09605	COG0116	Belongs to the methyltransferase superfamily
FXN65_RS09605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXN65_RS09615	COG2027	D-alanyl-D-alanine carboxypeptidase
FXN65_RS09620	COG3171	Protein conserved in bacteria
FXN65_RS09625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FXN65_RS09625	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FXN65_RS09630	COG2197	response regulator
FXN65_RS09635	COG2205	protein histidine kinase activity
FXN65_RS09635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS09650	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FXN65_RS09675	COG0004	ammonium transporteR
FXN65_RS09695	COG0625	glutathione transferase activity
FXN65_RS09700	COG1309	transcriptional regulator
FXN65_RS09725	COG0746	molybdenum cofactor guanylyltransferase activity
FXN65_RS09730	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXN65_RS09735	COG0303	'Molybdopterin
FXN65_RS09755	COG1070	Carbohydrate kinase
FXN65_RS09780	COG0741	lytic transglycosylase activity
FXN65_RS09785	COG0488	(ABC) transporter
FXN65_RS09795	COG0589	response to stress
FXN65_RS09815	COG0183	Belongs to the thiolase family
FXN65_RS09845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FXN65_RS09870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXN65_RS09880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXN65_RS09890	COG1113	amino acid transport
FXN65_RS09900	COG1805	sodium ion transport
FXN65_RS09925	COG1477	protein flavinylation
FXN65_RS09935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN65_RS09940	COG0584	glycerophosphoryl diester phosphodiesterase
FXN65_RS09955	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN65_RS09965	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN65_RS09980	COG0811	peptide transport
FXN65_RS09985	COG0848	biopolymer transport protein
FXN65_RS09990	COG1663	tetraacyldisaccharide 4'-kinase activity
FXN65_RS09995	COG2835	tetraacyldisaccharide 4'-kinase activity
FXN65_RS10000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FXN65_RS10005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXN65_RS10010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXN65_RS10015	COG3123	guanosine phosphorylase activity
FXN65_RS10025	COG2084	Dehydrogenase
FXN65_RS10055	COG2009	succinate dehydrogenase
FXN65_RS10060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FXN65_RS10065	COG1053	succinate dehydrogenase
FXN65_RS10070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FXN65_RS10090	COG0045	succinate-CoA ligase (ADP-forming) activity
FXN65_RS10150	COG1741	Belongs to the pirin family
FXN65_RS10175	COG0784	Response regulator, receiver
FXN65_RS10175	COG4191	Histidine kinase
FXN65_RS10180	COG2020	methyltransferase activity
FXN65_RS10195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXN65_RS10200	COG0784	Response regulator, receiver
FXN65_RS10200	COG2205	protein histidine kinase activity
FXN65_RS10200	COG5002	protein histidine kinase activity
FXN65_RS10220	COG1022	Amp-dependent synthetase and ligase
FXN65_RS10235	COG1280	lysine exporter protein (LysE YggA)
FXN65_RS10255	COG0628	permease
FXN65_RS10265	COG2267	carboxylic ester hydrolase activity
FXN65_RS10295	COG2205	protein histidine kinase activity
FXN65_RS10300	COG0745	RESPONSE REGULATOR receiver
FXN65_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS10340	COG0697	spore germination
FXN65_RS10350	COG0519	Catalyzes the synthesis of GMP from XMP
FXN65_RS10350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FXN65_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS10360	COG1177	transmembrane transport
FXN65_RS10365	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS10370	COG3842	ATPase activity
FXN65_RS10375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS10390	COG0840	transmembrane signaling receptor activity
FXN65_RS10395	COG1968	undecaprenyl-diphosphatase activity
FXN65_RS10410	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FXN65_RS10410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FXN65_RS10430	COG2853	Lipoprotein
FXN65_RS10440	COG0745	RESPONSE REGULATOR receiver
FXN65_RS10450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXN65_RS10455	COG0735	belongs to the Fur family
FXN65_RS10470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXN65_RS10490	COG0625	glutathione transferase activity
FXN65_RS10495	COG1131	(ABC) transporter
FXN65_RS10500	COG0842	Transport permease protein
FXN65_RS10510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN65_RS10540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXN65_RS10545	COG0488	(ABC) transporter
FXN65_RS10935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN65_RS10950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXN65_RS10955	COG0583	DNA-binding transcription factor activity
FXN65_RS10960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXN65_RS10965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FXN65_RS10975	COG2031	fatty acid transporter
FXN65_RS10990	COG1024	Enoyl-CoA hydratase
FXN65_RS10990	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXN65_RS10995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FXN65_RS11000	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS11005	COG0789	Transcriptional regulator
FXN65_RS11015	COG1132	(ABC) transporter
FXN65_RS11020	COG1404	Belongs to the peptidase S8 family
FXN65_RS11030	COG2199	diguanylate cyclase activity
FXN65_RS11040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS11050	COG0174	glutamine synthetase
FXN65_RS11055	COG0039	L-malate dehydrogenase activity
FXN65_RS11085	COG2823	Periplasmic or secreted lipoprotein
FXN65_RS11110	COG3237	CsbD-like
FXN65_RS11135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXN65_RS11145	COG3391	amine dehydrogenase activity
FXN65_RS11150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS11155	COG1129	ABC transporter
FXN65_RS11155	COG0842	Transport permease protein
FXN65_RS11160	COG0842	Transport permease protein
FXN65_RS11170	COG1280	lysine exporter protein (LysE YggA)
FXN65_RS11175	COG1522	sequence-specific DNA binding
FXN65_RS11250	COG1966	Carbon starvation protein
FXN65_RS11255	COG2879	small protein
FXN65_RS11260	COG0523	cobalamin synthesis protein
FXN65_RS11275	COG0417	DNA replication proofreading
FXN65_RS11310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FXN65_RS11320	COG2233	PERMEase
FXN65_RS11350	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS11355	COG2271	Major facilitator Superfamily
FXN65_RS11360	COG1082	Xylose isomerase domain protein TIM barrel
FXN65_RS11380	COG4566	intracellular signal transduction
FXN65_RS11395	COG4628	conserved protein (DUF2132)
FXN65_RS11405	COG0210	DNA helicase
FXN65_RS11410	COG3265	gluconokinase activity
FXN65_RS11430	COG0657	acetylesterase activity
FXN65_RS11480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS11515	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FXN65_RS11535	COG1984	allophanate hydrolase subunit 2
FXN65_RS11540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FXN65_RS11555	COG2814	Major facilitator Superfamily
FXN65_RS11560	COG0583	DNA-binding transcription factor activity
FXN65_RS11595	COG2197	response regulator
FXN65_RS11605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS11630	COG0154	amidase activity
FXN65_RS11645	COG1764	response to oxidative stress
FXN65_RS11670	COG2814	Major facilitator Superfamily
FXN65_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS11680	COG0583	DNA-binding transcription factor activity
FXN65_RS11700	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS11705	COG1024	Enoyl-CoA hydratase
FXN65_RS11715	COG1024	Enoyl-CoA hydratase
FXN65_RS11725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXN65_RS11735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN65_RS11745	COG0583	DNA-binding transcription factor activity
FXN65_RS11760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS11765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN65_RS11805	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS11815	COG0840	transmembrane signaling receptor activity
FXN65_RS11820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXN65_RS11830	COG0183	Belongs to the thiolase family
FXN65_RS11835	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS11840	COG1024	Enoyl-CoA hydratase
FXN65_RS11850	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS11855	COG0861	Integral membrane protein TerC family
FXN65_RS11875	COG0708	Exodeoxyribonuclease III
FXN65_RS11885	COG0729	surface antigen
FXN65_RS11920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXN65_RS11965	COG0583	DNA-binding transcription factor activity
FXN65_RS11975	COG0590	tRNA wobble adenosine to inosine editing
FXN65_RS11980	COG2807	transmembrane transport
FXN65_RS11995	COG3530	Putative quorum-sensing-regulated virulence factor
FXN65_RS12010	COG1137	ATPase activity
FXN65_RS12030	COG0583	DNA-binding transcription factor activity
FXN65_RS12045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FXN65_RS12050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FXN65_RS12080	COG3204	pilus organization
FXN65_RS12085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FXN65_RS12090	COG0463	Glycosyl transferase, family 2
FXN65_RS12120	COG2194	sulfuric ester hydrolase activity
FXN65_RS12145	COG0625	glutathione transferase activity
FXN65_RS12190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS12200	COG0604	alcohol dehydrogenase
FXN65_RS12205	COG2207	Transcriptional regulator
FXN65_RS12230	COG4221	oxidoreductase activity
FXN65_RS12275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXN65_RS12280	COG1760	l-serine dehydratase
FXN65_RS12285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS12285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS12290	COG0509	glycine decarboxylation via glycine cleavage system
FXN65_RS12325	COG0784	Response regulator, receiver
FXN65_RS12325	COG2205	protein histidine kinase activity
FXN65_RS12350	COG1131	(ABC) transporter
FXN65_RS12365	COG3851	Histidine kinase
FXN65_RS12400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN65_RS12415	COG0840	transmembrane signaling receptor activity
FXN65_RS12430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FXN65_RS12435	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FXN65_RS12445	COG0535	radical SAM domain protein
FXN65_RS12465	COG4178	(ABC) transporter
FXN65_RS12485	COG2259	Doxx family
FXN65_RS12495	COG3220	belongs to the UPF0276 family
FXN65_RS12515	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS12525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN65_RS12540	COG1846	Transcriptional regulator
FXN65_RS12560	COG0583	DNA-binding transcription factor activity
FXN65_RS12565	COG3485	protocatechuate 3,4-dioxygenase
FXN65_RS12570	COG3485	protocatechuate 3,4-dioxygenase
FXN65_RS12575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FXN65_RS12580	COG0679	Auxin Efflux Carrier
FXN65_RS12585	COG0778	Nitroreductase
FXN65_RS12590	COG1414	Transcriptional regulator
FXN65_RS12625	COG2814	Major facilitator Superfamily
FXN65_RS12630	COG3135	benzoate transporter
FXN65_RS12645	COG0604	alcohol dehydrogenase
FXN65_RS12650	COG1309	transcriptional regulator
FXN65_RS12695	COG0183	Belongs to the thiolase family
FXN65_RS12715	COG0583	DNA-binding transcription factor activity
FXN65_RS12720	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FXN65_RS12750	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS12755	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS12765	COG1959	2 iron, 2 sulfur cluster binding
FXN65_RS12780	COG2072	flavoprotein involved in K transport
FXN65_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS12830	COG0668	transmembrane transport
FXN65_RS12840	COG2067	long-chain fatty acid transport protein
FXN65_RS12845	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FXN65_RS12860	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FXN65_RS12875	COG0789	Transcriptional regulator
FXN65_RS12885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXN65_RS12925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS12940	COG0628	permease
FXN65_RS12970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN65_RS12985	COG2271	Major facilitator Superfamily
FXN65_RS12995	COG2909	trisaccharide binding
FXN65_RS13030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FXN65_RS13045	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS13050	COG1064	alcohol dehydrogenase
FXN65_RS13065	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS13080	COG1024	Enoyl-CoA hydratase
FXN65_RS13090	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13095	COG1024	Enoyl-CoA hydratase
FXN65_RS13100	COG0183	Belongs to the thiolase family
FXN65_RS13105	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13110	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS13125	COG1022	Amp-dependent synthetase and ligase
FXN65_RS13130	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13135	COG0183	Belongs to the thiolase family
FXN65_RS13145	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS13165	COG0183	Belongs to the thiolase family
FXN65_RS13170	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXN65_RS13170	COG1024	Enoyl-CoA hydratase
FXN65_RS13175	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13220	COG1218	3'(2'),5'-bisphosphate nucleotidase
FXN65_RS13280	COG1280	lysine exporter protein (LysE YggA)
FXN65_RS13305	COG0625	glutathione transferase activity
FXN65_RS13320	COG1335	isochorismatase
FXN65_RS13325	COG2814	Major facilitator Superfamily
FXN65_RS13335	COG1309	transcriptional regulator
FXN65_RS13340	COG0604	alcohol dehydrogenase
FXN65_RS13345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FXN65_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS13360	COG1942	4-Oxalocrotonate Tautomerase
FXN65_RS13390	COG2258	MOSC domain
FXN65_RS13395	COG0583	DNA-binding transcription factor activity
FXN65_RS13400	COG2070	2-Nitropropane dioxygenase
FXN65_RS13410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN65_RS13415	COG3162	membrane
FXN65_RS13420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FXN65_RS13435	COG1942	4-Oxalocrotonate Tautomerase
FXN65_RS13440	COG0625	glutathione transferase activity
FXN65_RS13485	COG4977	sequence-specific DNA binding
FXN65_RS13520	COG0523	cobalamin synthesis protein
FXN65_RS13530	COG0154	amidase activity
FXN65_RS13545	COG0596	Alpha beta hydrolase
FXN65_RS13550	COG0656	L-ascorbic acid biosynthetic process
FXN65_RS13565	COG3284	Transcriptional regulator
FXN65_RS13580	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS13605	COG1999	signal sequence binding
FXN65_RS13615	COG4977	sequence-specific DNA binding
FXN65_RS13630	COG2030	dehydratase
FXN65_RS13640	COG0559	Belongs to the binding-protein-dependent transport system permease family
FXN65_RS13660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXN65_RS13685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS13705	COG1414	Transcriptional regulator
FXN65_RS13720	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS13730	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13735	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
FXN65_RS13760	COG0427	acetyl-CoA hydrolase
FXN65_RS13770	COG0697	spore germination
FXN65_RS13805	COG1733	regulation of RNA biosynthetic process
FXN65_RS13810	COG0604	alcohol dehydrogenase
FXN65_RS13835	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS13850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FXN65_RS13855	COG1733	regulation of RNA biosynthetic process
FXN65_RS13860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FXN65_RS13870	COG0840	transmembrane signaling receptor activity
FXN65_RS13880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXN65_RS13900	COG2207	Transcriptional regulator
FXN65_RS13920	COG0659	secondary active sulfate transmembrane transporter activity
FXN65_RS13940	COG1105	Belongs to the carbohydrate kinase PfkB family
FXN65_RS13945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FXN65_RS13955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FXN65_RS13960	COG0589	response to stress
FXN65_RS13975	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN65_RS13975	COG0022	dehydrogenase e1 component
FXN65_RS13980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FXN65_RS13985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FXN65_RS13995	COG1796	DNA polymerase
FXN65_RS13995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FXN65_RS14000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FXN65_RS14015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXN65_RS14040	COG0459	protein refolding
FXN65_RS14050	COG0589	response to stress
FXN65_RS14055	COG0589	response to stress
FXN65_RS14075	COG0071	Belongs to the small heat shock protein (HSP20) family
FXN65_RS14080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FXN65_RS14085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FXN65_RS14115	COG2132	Multicopper oxidase
FXN65_RS14120	COG0642	Histidine kinase
FXN65_RS14140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXN65_RS14145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FXN65_RS14150	COG2814	Major facilitator Superfamily
FXN65_RS14155	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FXN65_RS14160	COG3224	Antibiotic biosynthesis monooxygenase
FXN65_RS14180	COG1335	isochorismatase
FXN65_RS14205	COG0583	DNA-binding transcription factor activity
FXN65_RS14225	COG0625	glutathione transferase activity
FXN65_RS14280	COG0640	Transcriptional regulator
FXN65_RS14285	COG0778	Nitroreductase
FXN65_RS14290	COG2203	Gaf domain
FXN65_RS14290	COG4251	negative regulation of phosphorylation
FXN65_RS14290	COG3706	GGDEF domain
FXN65_RS14290	COG5001	Diguanylate cyclase
FXN65_RS14305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXN65_RS14335	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN65_RS14350	COG0826	peptidase U32
FXN65_RS14380	COG4991	sh3 domain protein
FXN65_RS14415	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FXN65_RS14440	COG1942	4-Oxalocrotonate Tautomerase
FXN65_RS14445	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FXN65_RS14465	COG4221	oxidoreductase activity
FXN65_RS14500	COG2259	Doxx family
FXN65_RS14510	COG1764	response to oxidative stress
FXN65_RS14520	COG3220	belongs to the UPF0276 family
FXN65_RS14545	COG2957	Belongs to the agmatine deiminase family
FXN65_RS14560	COG2957	Belongs to the agmatine deiminase family
FXN65_RS14565	COG0583	DNA-binding transcription factor activity
FXN65_RS14570	COG3005	denitrification pathway
FXN65_RS14580	COG0243	molybdopterin cofactor binding
FXN65_RS14585	COG3062	negative regulation of establishment of protein localization
FXN65_RS14590	COG4459	periplasmic nitrate reductase
FXN65_RS14595	COG0596	Alpha beta hydrolase
FXN65_RS14655	COG2175	clavaminate synthase activity
FXN65_RS14660	COG3246	L-lysine catabolic process to acetate
FXN65_RS14675	COG0251	oxidation-reduction process
FXN65_RS14685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS14695	COG1113	amino acid transport
FXN65_RS14710	COG0765	amino acid transport
FXN65_RS14715	COG0765	amino acid transport
FXN65_RS14740	COG4221	oxidoreductase activity
FXN65_RS14745	COG2207	Transcriptional regulator
FXN65_RS14750	COG5001	Diguanylate cyclase
FXN65_RS14750	COG3300	MHYT domain
FXN65_RS14775	COG2203	Gaf domain
FXN65_RS14775	COG2199	diguanylate cyclase activity
FXN65_RS14820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FXN65_RS14825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FXN65_RS14840	COG3781	membrane
FXN65_RS14860	COG0583	DNA-binding transcription factor activity
FXN65_RS14865	COG0477	Major facilitator Superfamily
FXN65_RS14870	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS14885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS14895	COG1024	Enoyl-CoA hydratase
FXN65_RS14905	COG0183	Belongs to the thiolase family
FXN65_RS14940	COG1566	PFAM secretion protein HlyD family protein
FXN65_RS14945	COG2814	Major facilitator Superfamily
FXN65_RS14970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FXN65_RS14975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN65_RS14980	COG1414	Transcriptional regulator
FXN65_RS14985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN65_RS14990	COG1053	succinate dehydrogenase
FXN65_RS15000	COG1053	succinate dehydrogenase
FXN65_RS15005	COG1309	transcriptional regulator
FXN65_RS15010	COG1082	Xylose isomerase domain protein TIM barrel
FXN65_RS15010	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FXN65_RS15015	COG0477	Major facilitator Superfamily
FXN65_RS15020	COG0697	spore germination
FXN65_RS15040	COG1053	succinate dehydrogenase
FXN65_RS15045	COG0656	L-ascorbic acid biosynthetic process
FXN65_RS15050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN65_RS15055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN65_RS15065	COG0183	Belongs to the thiolase family
FXN65_RS15070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FXN65_RS15075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXN65_RS15150	COG0477	Major facilitator Superfamily
FXN65_RS15155	COG4977	sequence-specific DNA binding
FXN65_RS15160	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS15185	COG2814	Major facilitator Superfamily
FXN65_RS15190	COG0861	Integral membrane protein TerC family
FXN65_RS15200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXN65_RS15210	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS15215	COG0583	DNA-binding transcription factor activity
FXN65_RS15285	COG4695	Portal protein
FXN65_RS15450	COG4680	protein conserved in bacteria
FXN65_RS15455	COG5499	transcription regulator containing HTH domain
FXN65_RS15550	COG2920	part of a sulfur-relay system
FXN65_RS15555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FXN65_RS15560	COG0435	Glutathione S-transferase
FXN65_RS15565	COG1648	precorrin-2 dehydrogenase activity
FXN65_RS15565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FXN65_RS15575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FXN65_RS15580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXN65_RS15595	COG0492	ferredoxin-NADP+ reductase activity
FXN65_RS15600	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FXN65_RS15605	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FXN65_RS15610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FXN65_RS15615	COG0542	response to heat
FXN65_RS15620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FXN65_RS15625	COG1278	Cold shock
FXN65_RS15650	COG0482	sulfurtransferase activity
FXN65_RS15665	COG2850	peptidyl-arginine hydroxylation
FXN65_RS15670	COG2153	protein acetylation
FXN65_RS15700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXN65_RS15705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXN65_RS15710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXN65_RS15710	COG0649	NAD binding
FXN65_RS15730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FXN65_RS15745	COG0713	ATP synthesis coupled electron transport
FXN65_RS15760	COG1007	ATP synthesis coupled electron transport
FXN65_RS15770	COG2056	Na+-H+ antiporter family
FXN65_RS15775	COG0840	transmembrane signaling receptor activity
FXN65_RS15780	COG0431	NADPH-dependent FMN reductase
FXN65_RS15795	COG2010	Cytochrome c
FXN65_RS15815	COG0330	HflC and HflK could
FXN65_RS15820	COG0686	Belongs to the AlaDH PNT family
FXN65_RS15840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN65_RS15850	COG1595	DNA-templated transcription, initiation
FXN65_RS15855	COG0753	catalase activity
FXN65_RS15860	COG3038	cytochrome b561
FXN65_RS15895	COG1045	serine acetyltransferase
FXN65_RS15900	COG2866	Carboxypeptidase
FXN65_RS15910	COG0583	DNA-binding transcription factor activity
FXN65_RS15920	COG2350	Protein conserved in bacteria
FXN65_RS15925	COG3485	protocatechuate 3,4-dioxygenase
FXN65_RS15935	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS15955	COG0523	cobalamin synthesis protein
FXN65_RS15965	COG1473	amidohydrolase
FXN65_RS15975	COG3842	ATPase activity
FXN65_RS15990	COG1177	transmembrane transport
FXN65_RS15995	COG0235	Class ii aldolase
FXN65_RS16000	COG0583	DNA-binding transcription factor activity
FXN65_RS16005	COG1609	Transcriptional regulator
FXN65_RS16015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FXN65_RS16030	COG2203	Gaf domain
FXN65_RS16030	COG3706	GGDEF domain
FXN65_RS16030	COG4251	negative regulation of phosphorylation
FXN65_RS16030	COG5001	Diguanylate cyclase
FXN65_RS16035	COG3158	transport of potassium into the cell
FXN65_RS16090	COG1566	PFAM secretion protein HlyD family protein
FXN65_RS16105	COG4447	cellulose binding
FXN65_RS16125	COG2207	Transcriptional regulator
FXN65_RS16130	COG2855	membrane
FXN65_RS16145	COG2814	Major facilitator Superfamily
FXN65_RS16150	COG3246	L-lysine catabolic process to acetate
FXN65_RS16155	COG2175	clavaminate synthase activity
FXN65_RS16175	COG2079	MmgE PrpD family protein
FXN65_RS16180	COG4772	TonB-dependent receptor
FXN65_RS16215	COG0789	Transcriptional regulator
FXN65_RS16220	COG0659	secondary active sulfate transmembrane transporter activity
FXN65_RS16230	COG5002	protein histidine kinase activity
FXN65_RS16230	COG3447	MASE1 domain protein
FXN65_RS16230	COG5001	Diguanylate cyclase
FXN65_RS16235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXN65_RS16255	COG0473	3-isopropylmalate dehydrogenase activity
FXN65_RS16260	COG0583	DNA-binding transcription factor activity
FXN65_RS16275	COG0174	glutamine synthetase
FXN65_RS16280	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS16290	COG2207	Transcriptional regulator
FXN65_RS16295	COG3327	negative regulation of DNA-templated transcription, initiation
FXN65_RS16310	COG1024	Enoyl-CoA hydratase
FXN65_RS16315	COG1024	Enoyl-CoA hydratase
FXN65_RS16320	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXN65_RS16325	COG2050	protein possibly involved in aromatic compounds catabolism
FXN65_RS16330	COG0183	Belongs to the thiolase family
FXN65_RS16340	COG5507	3-demethylubiquinone-9 3-methyltransferase
FXN65_RS16440	COG3396	Phenylacetate-CoA oxygenase
FXN65_RS16445	COG3460	Phenylacetate-CoA oxygenase
FXN65_RS16450	COG3396	Phenylacetate-CoA oxygenase
FXN65_RS16455	COG2151	metal-sulfur cluster biosynthetic enzyme
FXN65_RS16460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FXN65_RS16480	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS16480	COG2030	dehydratase
FXN65_RS16490	COG0840	transmembrane signaling receptor activity
FXN65_RS16550	COG2909	trisaccharide binding
FXN65_RS16590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FXN65_RS16625	COG1376	ErfK ybiS ycfS ynhG family protein
FXN65_RS16640	COG4181	ATPase activity
FXN65_RS16645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FXN65_RS16660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FXN65_RS16675	COG2259	Doxx family
FXN65_RS16680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXN65_RS16685	COG0084	hydrolase, TatD family'
FXN65_RS16720	COG0714	Associated with various cellular activities
FXN65_RS16730	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS16740	COG1595	DNA-templated transcription, initiation
FXN65_RS16745	COG3712	iron ion homeostasis
FXN65_RS16750	COG4774	siderophore transport
FXN65_RS16800	COG0625	glutathione transferase activity
FXN65_RS16805	COG1956	GAF domain-containing protein
FXN65_RS16815	COG2205	protein histidine kinase activity
FXN65_RS16815	COG0784	Response regulator, receiver
FXN65_RS16820	COG1846	Transcriptional regulator
FXN65_RS16825	COG0386	Belongs to the glutathione peroxidase family
FXN65_RS16835	COG0436	Aminotransferase
FXN65_RS16850	COG0500	methyltransferase
FXN65_RS16855	COG3384	dioxygenase
FXN65_RS16865	COG1024	Enoyl-CoA hydratase
FXN65_RS16875	COG0492	ferredoxin-NADP+ reductase activity
FXN65_RS16885	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FXN65_RS16890	COG3214	Protein conserved in bacteria
FXN65_RS16905	COG0583	DNA-binding transcription factor activity
FXN65_RS16915	COG0583	DNA-binding transcription factor activity
FXN65_RS16925	COG1846	Transcriptional regulator
FXN65_RS16930	COG0657	acetylesterase activity
FXN65_RS16950	COG0840	transmembrane signaling receptor activity
FXN65_RS16960	COG3108	Peptidase M15
FXN65_RS16995	COG0640	Transcriptional regulator
FXN65_RS17005	COG0798	PFAM Bile acid sodium symporter
FXN65_RS17010	COG0431	NADPH-dependent FMN reductase
FXN65_RS17015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN65_RS17030	COG1278	Cold shock
FXN65_RS17050	COG2267	carboxylic ester hydrolase activity
FXN65_RS17055	COG0598	Magnesium transport protein CorA
FXN65_RS17060	COG0519	Catalyzes the synthesis of GMP from XMP
FXN65_RS17080	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXN65_RS17080	COG1024	Enoyl-CoA hydratase
FXN65_RS17085	COG0183	Belongs to the thiolase family
FXN65_RS17095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN65_RS17110	COG1305	Transglutaminase-like
FXN65_RS17120	COG2308	Evidence 4 Homologs of previously reported genes of
FXN65_RS17125	COG0450	alkyl hydroperoxide reductase
FXN65_RS17175	COG3604	Transcriptional regulator
FXN65_RS17180	COG0720	synthase
FXN65_RS17250	COG2181	nitrate reductase activity
FXN65_RS17255	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FXN65_RS17260	COG1140	nitrate reductase beta subunit
FXN65_RS17265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FXN65_RS17270	COG2223	nitrite transmembrane transporter activity
FXN65_RS17280	COG3850	Histidine kinase
FXN65_RS17285	COG2197	response regulator
FXN65_RS17300	COG3154	lipid carrier protein
FXN65_RS17305	COG0826	peptidase U32
FXN65_RS17310	COG0826	peptidase U32
FXN65_RS17315	COG0303	'Molybdopterin
FXN65_RS17320	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXN65_RS17325	COG0315	cyclic pyranopterin monophosphate synthase activity
FXN65_RS17330	COG3604	Transcriptional regulator
FXN65_RS17335	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
FXN65_RS17350	COG2204	response regulator
FXN65_RS17355	COG2610	gluconate transmembrane transporter activity
FXN65_RS17360	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS17370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FXN65_RS17380	COG3665	Urea carboxylase-associated protein
FXN65_RS17390	COG4770	biotin carboxylase activity
FXN65_RS17405	COG4221	oxidoreductase activity
FXN65_RS17420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FXN65_RS17435	COG3046	protein related to deoxyribodipyrimidine photolyase
FXN65_RS17505	COG1454	alcohol dehydrogenase
FXN65_RS17510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS17515	COG0583	DNA-binding transcription factor activity
FXN65_RS17565	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FXN65_RS17570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXN65_RS17680	COG2003	Belongs to the UPF0758 family
FXN65_RS17745	COG0776	regulation of translation
FXN65_RS17750	COG0072	phenylalanine-tRNA ligase activity
FXN65_RS17755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXN65_RS17760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXN65_RS17765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXN65_RS17775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FXN65_RS17785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS17805	COG3813	Protein conserved in bacteria
FXN65_RS17815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FXN65_RS17815	COG0316	Belongs to the HesB IscA family
FXN65_RS17845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FXN65_RS17860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXN65_RS17880	COG0616	signal peptide processing
FXN65_RS17885	COG0406	alpha-ribazole phosphatase activity
FXN65_RS17900	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS17915	COG2816	NAD+ diphosphatase activity
FXN65_RS17925	COG1024	Enoyl-CoA hydratase
FXN65_RS17930	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FXN65_RS17935	COG0531	amino acid
FXN65_RS17950	COG0328	RNA-DNA hybrid ribonuclease activity
FXN65_RS17965	COG0741	lytic transglycosylase activity
FXN65_RS17965	COG1388	LysM domain
FXN65_RS17975	COG4166	transmembrane transport
FXN65_RS17980	COG4166	transmembrane transport
FXN65_RS17985	COG4174	ABC transporter (Permease)
FXN65_RS17990	COG4239	(ABC) transporter, permease
FXN65_RS17995	COG4172	Belongs to the ABC transporter superfamily
FXN65_RS18005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN65_RS18015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN65_RS18030	COG0544	peptidyl-prolyl cis-trans isomerase activity
FXN65_RS18055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FXN65_RS18060	COG0215	cysteine-tRNA ligase activity
FXN65_RS18070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FXN65_RS18075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN65_RS18090	COG0589	response to stress
FXN65_RS18110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FXN65_RS18115	COG2201	protein-glutamate methylesterase activity
FXN65_RS18125	COG0436	Aminotransferase
FXN65_RS18145	COG2223	nitrite transmembrane transporter activity
FXN65_RS18150	COG0515	serine threonine protein kinase
FXN65_RS18150	COG2815	serine threonine protein kinase
FXN65_RS18155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FXN65_RS18175	COG0668	transmembrane transport
FXN65_RS18215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FXN65_RS18240	COG1802	Transcriptional regulator
FXN65_RS18245	COG0189	ligase activity
FXN65_RS18245	COG4067	protein conserved in archaea
FXN65_RS18260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FXN65_RS18285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FXN65_RS18290	COG0235	Class ii aldolase
FXN65_RS18300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXN65_RS18305	COG1073	alpha beta
FXN65_RS18330	COG2840	Smr protein MutS2
FXN65_RS18365	COG0625	glutathione transferase activity
FXN65_RS18370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS18390	COG3135	benzoate transporter
FXN65_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS18400	COG2130	NADP-dependent
FXN65_RS18415	COG0583	DNA-binding transcription factor activity
FXN65_RS18440	COG1309	transcriptional regulator
FXN65_RS18455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FXN65_RS18460	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS18465	COG1024	Enoyl-CoA hydratase
FXN65_RS18480	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS18500	COG1595	DNA-templated transcription, initiation
FXN65_RS18505	COG2304	oxidoreductase activity
FXN65_RS18510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FXN65_RS18515	COG2885	chlorophyll binding
FXN65_RS18560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXN65_RS18575	COG0084	hydrolase, TatD family'
FXN65_RS18595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXN65_RS18605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN65_RS18610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXN65_RS18625	COG0416	fatty acid biosynthetic process
FXN65_RS18630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FXN65_RS18640	COG0424	maF-like protein
FXN65_RS18650	COG0546	phosphoglycolate phosphatase activity
FXN65_RS18660	COG1530	ribonuclease E activity
FXN65_RS18665	COG1132	(ABC) transporter
FXN65_RS18675	COG3011	Protein conserved in bacteria
FXN65_RS18685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXN65_RS18710	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FXN65_RS18720	COG0840	transmembrane signaling receptor activity
FXN65_RS18730	COG3278	Belongs to the heme-copper respiratory oxidase family
FXN65_RS18750	COG3278	Belongs to the heme-copper respiratory oxidase family
FXN65_RS18765	COG2010	Cytochrome c
FXN65_RS18770	COG0348	domain, Protein
FXN65_RS18805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXN65_RS18810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FXN65_RS18855	COG0697	spore germination
FXN65_RS18860	COG0183	Belongs to the thiolase family
FXN65_RS18870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FXN65_RS18870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FXN65_RS18870	COG0506	proline dehydrogenase activity
FXN65_RS18880	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS18890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FXN65_RS18895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXN65_RS18910	COG0840	transmembrane signaling receptor activity
FXN65_RS18965	COG4964	Belongs to the GSP D family
FXN65_RS19005	COG3115	cell septum assembly
FXN65_RS19035	COG0402	S-adenosylhomocysteine deaminase activity
FXN65_RS19040	COG1802	Transcriptional regulator
FXN65_RS19045	COG2252	PERMEase
FXN65_RS19075	COG2233	PERMEase
FXN65_RS19105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXN65_RS19120	COG3960	tartronate-semialdehyde synthase activity
FXN65_RS19125	COG3622	Belongs to the hyi family
FXN65_RS19130	COG2084	Dehydrogenase
FXN65_RS19140	COG0469	pyruvate kinase activity
FXN65_RS19145	COG4413	Urea transporter
FXN65_RS19155	COG2814	Major facilitator Superfamily
FXN65_RS19170	COG3706	GGDEF domain
FXN65_RS19170	COG2203	Gaf domain
FXN65_RS19170	COG5001	Diguanylate cyclase
FXN65_RS19170	COG4251	negative regulation of phosphorylation
FXN65_RS19175	COG0514	ATP-dependent DNA helicase (RecQ)
FXN65_RS19185	COG2832	Protein of unknown function (DUF454)
FXN65_RS19195	COG3300	MHYT domain
FXN65_RS19195	COG5001	Diguanylate cyclase
FXN65_RS19215	COG2274	protein secretion by the type I secretion system
FXN65_RS19220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS19230	COG0840	transmembrane signaling receptor activity
FXN65_RS19255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS19260	COG0765	amino acid transport
FXN65_RS19265	COG1126	abc transporter atp-binding protein
FXN65_RS19270	COG0235	Class ii aldolase
FXN65_RS19275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN65_RS19280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN65_RS19285	COG0583	DNA-binding transcription factor activity
FXN65_RS19295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS19315	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FXN65_RS19320	COG0583	DNA-binding transcription factor activity
FXN65_RS19335	COG0583	DNA-binding transcription factor activity
FXN65_RS19350	COG0697	spore germination
FXN65_RS19365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXN65_RS19370	COG0542	response to heat
FXN65_RS19400	COG0121	glutamine amidotransferase
FXN65_RS19445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXN65_RS19460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN65_RS19475	COG1522	sequence-specific DNA binding
FXN65_RS19480	COG0626	cystathionine gamma-synthase activity
FXN65_RS19515	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS19520	COG2852	Protein conserved in bacteria
FXN65_RS19525	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FXN65_RS19530	COG0406	alpha-ribazole phosphatase activity
FXN65_RS19545	COG1492	cobalamin metabolic process
FXN65_RS19560	COG0778	Nitroreductase
FXN65_RS19575	COG4206	TonB-dependent receptor
FXN65_RS19580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FXN65_RS19595	COG0791	NLP P60 protein
FXN65_RS19600	COG0791	NLP P60 protein
FXN65_RS19630	COG3091	SprT-like family
FXN65_RS19635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS19650	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS19660	COG1917	Cupin 2, conserved barrel domain protein
FXN65_RS19660	COG4977	sequence-specific DNA binding
FXN65_RS19680	COG2977	Belongs to the P-Pant transferase superfamily
FXN65_RS19685	COG2205	protein histidine kinase activity
FXN65_RS19690	COG0745	RESPONSE REGULATOR receiver
FXN65_RS19695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN65_RS19695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN65_RS19700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN65_RS19710	COG1943	Transposase
FXN65_RS19740	COG3485	protocatechuate 3,4-dioxygenase
FXN65_RS19755	COG0583	DNA-binding transcription factor activity
FXN65_RS19760	COG3257	ureidoglycine aminohydrolase activity
FXN65_RS19780	COG2020	methyltransferase activity
FXN65_RS19805	COG2814	Major facilitator Superfamily
FXN65_RS19810	COG0583	DNA-binding transcription factor activity
FXN65_RS19815	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN65_RS19820	COG1595	DNA-templated transcription, initiation
FXN65_RS19825	COG1368	sulfuric ester hydrolase activity
FXN65_RS19850	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS19860	COG4221	oxidoreductase activity
FXN65_RS19890	COG4191	Histidine kinase
FXN65_RS19890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS19905	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FXN65_RS19910	COG0179	Fumarylacetoacetate (FAA) hydrolase
FXN65_RS19925	COG2011	ABC-type metal ion transport system permease component
FXN65_RS19935	COG1464	Belongs to the NlpA lipoprotein family
FXN65_RS19960	COG2011	ABC-type metal ion transport system permease component
FXN65_RS19980	COG2239	Acts as a magnesium transporter
FXN65_RS19995	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FXN65_RS20030	COG4941	Belongs to the sigma-70 factor family
FXN65_RS20035	COG3795	YCII-related domain
FXN65_RS20050	COG0504	CTP synthase activity
FXN65_RS20055	COG2329	Antibiotic biosynthesis monooxygenase
FXN65_RS20060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN65_RS20060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN65_RS20060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FXN65_RS20065	COG1105	Belongs to the carbohydrate kinase PfkB family
FXN65_RS20075	COG1609	Transcriptional regulator
FXN65_RS20130	COG0531	amino acid
FXN65_RS20135	COG0840	transmembrane signaling receptor activity
FXN65_RS20145	COG0251	oxidation-reduction process
FXN65_RS20150	COG4948	Mandelate Racemase Muconate Lactonizing
FXN65_RS20160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXN65_RS20165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXN65_RS20180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXN65_RS20185	COG1760	l-serine dehydratase
FXN65_RS20195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS20195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS20200	COG0509	glycine decarboxylation via glycine cleavage system
FXN65_RS20210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS20220	COG3842	ATPase activity
FXN65_RS20225	COG3833	ABC-type maltose transport systems, permease component
FXN65_RS20230	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS20245	COG3284	Transcriptional regulator
FXN65_RS20260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN65_RS20290	COG1522	sequence-specific DNA binding
FXN65_RS20300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FXN65_RS20305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FXN65_RS20320	COG0473	3-isopropylmalate dehydrogenase activity
FXN65_RS20325	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS20360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXN65_RS20365	COG0601	transmembrane transport
FXN65_RS20370	COG0747	negative chemotaxis
FXN65_RS20375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS20385	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS20390	COG1522	sequence-specific DNA binding
FXN65_RS20395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FXN65_RS20400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FXN65_RS20410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FXN65_RS20420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS20440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN65_RS20455	COG1061	Type III restriction enzyme res subunit
FXN65_RS20490	COG0583	DNA-binding transcription factor activity
FXN65_RS20500	COG1643	Atp-dependent helicase
FXN65_RS20505	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS20510	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS20520	COG2030	dehydratase
FXN65_RS20525	COG1566	PFAM secretion protein HlyD family protein
FXN65_RS20535	COG1289	transmembrane transporter activity
FXN65_RS20545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS20550	COG1131	(ABC) transporter
FXN65_RS20555	COG0842	Transport permease protein
FXN65_RS20565	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN65_RS20570	COG1178	ABC-type Fe3 transport system permease component
FXN65_RS20575	COG3842	ATPase activity
FXN65_RS20605	COG1522	sequence-specific DNA binding
FXN65_RS20610	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FXN65_RS20620	COG2239	Acts as a magnesium transporter
FXN65_RS20645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXN65_RS20650	COG0527	aspartate kinase activity
FXN65_RS20655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FXN65_RS20660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FXN65_RS20665	COG2988	succinylglutamate desuccinylase activity
FXN65_RS20675	COG3724	N-succinylarginine dihydrolase activity
FXN65_RS20680	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS20730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN65_RS20740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN65_RS20760	COG4106	trans-aconitate 2-methyltransferase activity
FXN65_RS20765	COG0500	methyltransferase
FXN65_RS20770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS20795	COG3300	MHYT domain
FXN65_RS20795	COG5001	Diguanylate cyclase
FXN65_RS20810	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FXN65_RS20840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FXN65_RS20855	COG0346	lactoylglutathione lyase activity
FXN65_RS20860	COG0137	argininosuccinate synthase activity
FXN65_RS20870	COG0418	dihydroorotase activity
FXN65_RS20880	COG0450	alkyl hydroperoxide reductase
FXN65_RS20895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FXN65_RS20900	COG0243	molybdopterin cofactor binding
FXN65_RS20910	COG3706	GGDEF domain
FXN65_RS20910	COG2203	Gaf domain
FXN65_RS20910	COG5001	Diguanylate cyclase
FXN65_RS20910	COG4251	negative regulation of phosphorylation
FXN65_RS20920	COG3842	ATPase activity
FXN65_RS20935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FXN65_RS20940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXN65_RS20970	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS20975	COG0010	Belongs to the arginase family
FXN65_RS20990	COG0509	glycine decarboxylation via glycine cleavage system
FXN65_RS20995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS20995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS21000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXN65_RS21005	COG1760	l-serine dehydratase
FXN65_RS21010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXN65_RS21020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FXN65_RS21025	COG0583	DNA-binding transcription factor activity
FXN65_RS21050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS21080	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS21105	COG2895	sulfate adenylyltransferase (ATP) activity
FXN65_RS21105	COG0529	Catalyzes the synthesis of activated sulfate
FXN65_RS21120	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS21140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FXN65_RS21145	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS21170	COG0450	alkyl hydroperoxide reductase
FXN65_RS21180	COG1201	RNA secondary structure unwinding
FXN65_RS21190	COG4106	trans-aconitate 2-methyltransferase activity
FXN65_RS21195	COG1611	Belongs to the LOG family
FXN65_RS21205	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS21220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FXN65_RS21225	COG4638	Rieske (2fe-2S)
FXN65_RS21265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN65_RS21280	COG0587	DNA-directed DNA polymerase activity
FXN65_RS21320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FXN65_RS21325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FXN65_RS21330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN65_RS21340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXN65_RS21350	COG0425	Belongs to the sulfur carrier protein TusA family
FXN65_RS21355	COG4783	chaperone-mediated protein folding
FXN65_RS21370	COG2197	response regulator
FXN65_RS21375	COG0784	Response regulator, receiver
FXN65_RS21375	COG5002	protein histidine kinase activity
FXN65_RS21390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXN65_RS21395	COG0602	queuosine metabolic process
FXN65_RS21400	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FXN65_RS21405	COG2885	chlorophyll binding
FXN65_RS21430	COG0824	Thioesterase
FXN65_RS21435	COG2255	four-way junction helicase activity
FXN65_RS21440	COG0632	four-way junction helicase activity
FXN65_RS21445	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FXN65_RS21465	COG0783	Belongs to the Dps family
FXN65_RS21470	COG3706	GGDEF domain
FXN65_RS21480	COG2900	Belongs to the SlyX family
FXN65_RS21500	COG0442	prolyl-tRNA aminoacylation
FXN65_RS21535	COG1295	ribonuclease BN
FXN65_RS21560	COG0628	permease
FXN65_RS21580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXN65_RS21595	COG3122	Protein conserved in bacteria
FXN65_RS21600	COG3956	TIGRFAM MazG family protein
FXN65_RS21605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN65_RS21610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXN65_RS21625	COG5002	protein histidine kinase activity
FXN65_RS21625	COG2205	protein histidine kinase activity
FXN65_RS21625	COG0784	Response regulator, receiver
FXN65_RS21630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN65_RS21645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXN65_RS21675	COG3038	cytochrome b561
FXN65_RS21685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXN65_RS21730	COG0583	DNA-binding transcription factor activity
FXN65_RS21750	COG3148	PFAM DTW domain containing protein
FXN65_RS21775	COG1546	Belongs to the CinA family
FXN65_RS21785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FXN65_RS21800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FXN65_RS21805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FXN65_RS21810	COG0585	pseudouridine synthase activity
FXN65_RS21815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FXN65_RS21820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FXN65_RS21825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXN65_RS21835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FXN65_RS21850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FXN65_RS21860	COG0037	tRNA processing
FXN65_RS21865	COG0825	malonyl-CoA metabolic process
FXN65_RS21880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN65_RS21885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN65_RS21905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXN65_RS21915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FXN65_RS21925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FXN65_RS21945	COG0052	Belongs to the universal ribosomal protein uS2 family
FXN65_RS21950	COG0024	Methionine aminopeptidase
FXN65_RS21955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FXN65_RS21960	COG0436	Aminotransferase
FXN65_RS21965	COG1393	Belongs to the ArsC family
FXN65_RS21975	COG2171	N-acyltransferase activity
FXN65_RS21990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FXN65_RS21995	COG1979	alcohol dehydrogenase
FXN65_RS22000	COG1215	transferase activity, transferring glycosyl groups
FXN65_RS22010	COG2226	methyltransferase
FXN65_RS22040	COG1131	(ABC) transporter
FXN65_RS22045	COG2937	Belongs to the GPAT DAPAT family
FXN65_RS22085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN65_RS22090	COG1309	transcriptional regulator
FXN65_RS22100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FXN65_RS22105	COG1801	Protein of unknown function DUF72
FXN65_RS22115	COG1214	PFAM Peptidase M22, glycoprotease
FXN65_RS22120	COG0563	adenylate kinase activity
FXN65_RS22125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FXN65_RS22135	COG0789	Transcriptional regulator
FXN65_RS22150	COG0154	amidase activity
FXN65_RS22175	COG1073	alpha beta
FXN65_RS22205	COG3706	GGDEF domain
FXN65_RS22205	COG2203	Gaf domain
FXN65_RS22205	COG4251	negative regulation of phosphorylation
FXN65_RS22205	COG5001	Diguanylate cyclase
FXN65_RS22240	COG2979	Protein of unknown function (DUF533)
FXN65_RS22245	COG0583	DNA-binding transcription factor activity
FXN65_RS22250	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS22255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN65_RS22260	COG3842	ATPase activity
FXN65_RS22265	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS22270	COG1177	transmembrane transport
FXN65_RS22275	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS22290	COG0590	tRNA wobble adenosine to inosine editing
FXN65_RS22305	COG3795	YCII-related domain
FXN65_RS22310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FXN65_RS22325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FXN65_RS22340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN65_RS22360	COG1607	acyl-coa hydrolase
FXN65_RS22370	COG0336	Belongs to the RNA methyltransferase TrmD family
FXN65_RS22375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FXN65_RS22380	COG0228	four-way junction DNA binding
FXN65_RS22385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXN65_RS22395	COG4536	flavin adenine dinucleotide binding
FXN65_RS22435	COG3034	peptidoglycan biosynthetic process
FXN65_RS22465	COG1024	Enoyl-CoA hydratase
FXN65_RS22475	COG3706	GGDEF domain
FXN65_RS22495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FXN65_RS22495	COG3153	acetyltransferase
FXN65_RS22515	COG0693	protein deglycase activity
FXN65_RS22525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXN65_RS22535	COG1902	pentaerythritol trinitrate reductase activity
FXN65_RS22540	COG2814	Major facilitator Superfamily
FXN65_RS22600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN65_RS22605	COG0583	DNA-binding transcription factor activity
FXN65_RS22615	COG1279	arginine transmembrane transporter activity
FXN65_RS22635	COG1704	LemA family
FXN65_RS22670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN65_RS22680	COG0642	Histidine kinase
FXN65_RS22695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXN65_RS22700	COG3030	protein affecting phage T7 exclusion by the F plasmid
FXN65_RS22710	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS22725	COG1595	DNA-templated transcription, initiation
FXN65_RS22730	COG3712	iron ion homeostasis
FXN65_RS22795	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN65_RS22825	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FXN65_RS22835	COG1024	Enoyl-CoA hydratase
FXN65_RS22840	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS22860	COG1346	cytolysis
FXN65_RS22865	COG1380	Effector of murein hydrolase LrgA
FXN65_RS22885	COG1366	Belongs to the anti-sigma-factor antagonist family
FXN65_RS22890	COG0789	Transcriptional regulator
FXN65_RS22910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXN65_RS22930	COG0492	ferredoxin-NADP+ reductase activity
FXN65_RS22945	COG1307	EDD domain protein, DegV family
FXN65_RS22955	COG1309	transcriptional regulator
FXN65_RS22960	COG0386	Belongs to the glutathione peroxidase family
FXN65_RS22985	COG0204	Acyl-transferase
FXN65_RS23005	COG2885	chlorophyll binding
FXN65_RS23010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN65_RS23055	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS23060	COG0183	Belongs to the thiolase family
FXN65_RS23075	COG1280	lysine exporter protein (LysE YggA)
FXN65_RS23080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN65_RS23090	COG0833	amino acid
FXN65_RS23095	COG2119	membrane
FXN65_RS23110	COG0501	Belongs to the peptidase M48B family
FXN65_RS23115	COG0840	transmembrane signaling receptor activity
FXN65_RS23120	COG2135	peptidase activity
FXN65_RS23170	COG0659	secondary active sulfate transmembrane transporter activity
FXN65_RS23180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FXN65_RS23185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXN65_RS23195	COG2271	Major facilitator Superfamily
FXN65_RS23205	COG1090	epimerase
FXN65_RS23210	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FXN65_RS23215	COG3272	Protein of unknown function (DUF1722)
FXN65_RS23220	COG0789	Transcriptional regulator
FXN65_RS23235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FXN65_RS23240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXN65_RS23250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXN65_RS23270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXN65_RS23290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXN65_RS23300	COG0012	GTP binding
FXN65_RS23310	COG1487	ribonuclease activity
FXN65_RS23330	COG0473	3-isopropylmalate dehydrogenase activity
FXN65_RS23340	COG0288	reversible hydration of carbon dioxide
FXN65_RS23345	COG0456	acetyltransferase
FXN65_RS23355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FXN65_RS23400	COG3008	intermembrane lipid transfer
FXN65_RS23405	COG2995	paraquat-inducible protein a
FXN65_RS23410	COG2995	paraquat-inducible protein a
FXN65_RS23480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FXN65_RS23485	COG1183	phosphatidylcholine synthase activity
FXN65_RS23495	COG0583	DNA-binding transcription factor activity
FXN65_RS23505	COG0028	Belongs to the TPP enzyme family
FXN65_RS23515	COG3098	single-species biofilm formation
FXN65_RS23525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN65_RS23555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN65_RS23560	COG4558	Periplasmic binding protein
FXN65_RS23565	COG3720	iron ion transport
FXN65_RS23570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FXN65_RS23575	COG4771	TonB-dependent receptor
FXN65_RS23590	COG0436	Aminotransferase
FXN65_RS23595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXN65_RS23600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FXN65_RS23610	COG4191	Histidine kinase
FXN65_RS23615	COG2204	response regulator
FXN65_RS23630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FXN65_RS23675	COG0116	Belongs to the methyltransferase superfamily
FXN65_RS23675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FXN65_RS23705	COG2823	Periplasmic or secreted lipoprotein
FXN65_RS23715	COG1185	polyribonucleotide nucleotidyltransferase activity
FXN65_RS23720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FXN65_RS23730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXN65_RS23740	COG0195	Participates in both transcription termination and antitermination
FXN65_RS23745	COG0779	Required for maturation of 30S ribosomal subunits
FXN65_RS23760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXN65_RS23770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXN65_RS23775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXN65_RS23785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FXN65_RS23835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXN65_RS23840	COG0497	DNA recombination
FXN65_RS23855	COG2914	Belongs to the UPF0125 (RnfH) family
FXN65_RS23865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FXN65_RS23870	COG2186	Transcriptional regulator
FXN65_RS23875	COG1620	l-lactate permease
FXN65_RS23900	COG2205	protein histidine kinase activity
FXN65_RS23900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS23915	COG1196	nuclear chromosome segregation
FXN65_RS24005	COG1111	helicase
FXN65_RS24005	COG1205	dead DEAH box helicase
FXN65_RS24025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXN65_RS24045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FXN65_RS24110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FXN65_RS24130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN65_RS24175	COG1737	Transcriptional regulator
FXN65_RS24195	COG4215	(ABC) transporter
FXN65_RS24200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN65_RS24215	COG2197	response regulator
FXN65_RS24220	COG1028	Short-chain dehydrogenase reductase Sdr
FXN65_RS24240	COG2204	response regulator
FXN65_RS24245	COG5002	protein histidine kinase activity
FXN65_RS24305	COG4796	Type ii and iii secretion system protein
FXN65_RS24365	COG0741	lytic transglycosylase activity
FXN65_RS24375	COG1459	type II secretion system
FXN65_RS24390	COG2204	response regulator
FXN65_RS24395	COG4191	Histidine kinase
FXN65_RS24445	COG2824	Alkylphosphonate utilization operon protein PhnA
FXN65_RS24450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS24475	COG1309	transcriptional regulator
FXN65_RS24485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FXN65_RS24490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FXN65_RS24505	COG5002	protein histidine kinase activity
FXN65_RS24505	COG5001	Diguanylate cyclase
FXN65_RS24505	COG3447	MASE1 domain protein
FXN65_RS24510	COG0583	DNA-binding transcription factor activity
FXN65_RS24530	COG2814	Major facilitator Superfamily
FXN65_RS24550	COG2217	Heavy metal translocating P-type atpase
FXN65_RS24560	COG2217	Heavy metal translocating P-type atpase
FXN65_RS24570	COG0697	spore germination
FXN65_RS24585	COG0583	DNA-binding transcription factor activity
FXN65_RS24590	COG2910	NAD(P)H-binding
FXN65_RS24600	COG2207	Transcriptional regulator
FXN65_RS24640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FXN65_RS24735	COG4974	Belongs to the 'phage' integrase family
FXN65_RS24750	COG3276	selenocysteine insertion sequence binding
FXN65_RS24765	COG2864	formate dehydrogenase
FXN65_RS24770	COG0437	4 iron, 4 sulfur cluster binding
FXN65_RS24835	COG4964	Belongs to the GSP D family
FXN65_RS24875	COG0840	transmembrane signaling receptor activity
FXN65_RS24880	COG4953	penicillin-binding protein 1C
FXN65_RS24890	COG2373	Large extracellular alpha-helical protein
FXN65_RS24895	COG0534	Mate efflux family protein
FXN65_RS24905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FXN65_RS24910	COG1166	arginine decarboxylase activity
FXN65_RS24915	COG0023	Translation Initiation Factor
FXN65_RS24960	COG2264	protein methyltransferase activity
FXN65_RS25005	COG2095	MarC family integral membrane protein
FXN65_RS25015	COG0683	leucine binding
FXN65_RS25030	COG0411	ABC transporter
FXN65_RS25040	COG0829	nickel cation binding
FXN65_RS25045	COG0831	urea catabolic process
FXN65_RS25055	COG0832	Belongs to the urease beta subunit family
FXN65_RS25060	COG0804	urea catabolic process
FXN65_RS25070	COG2026	Addiction module toxin, RelE StbE family
FXN65_RS25075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXN65_RS25080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FXN65_RS25085	COG1238	metal cluster binding
FXN65_RS25105	COG0443	Heat shock 70 kDa protein
FXN65_RS25120	COG2982	Protein involved in outer membrane biogenesis
FXN65_RS25150	COG0830	nickel cation binding
FXN65_RS25155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FXN65_RS25165	COG0584	glycerophosphoryl diester phosphodiesterase
FXN65_RS25170	COG4221	oxidoreductase activity
FXN65_RS25180	COG2423	ornithine cyclodeaminase activity
FXN65_RS25210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS25215	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS25220	COG0583	DNA-binding transcription factor activity
FXN65_RS25230	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FXN65_RS25255	COG0668	transmembrane transport
FXN65_RS25300	COG0305	Participates in initiation and elongation during chromosome replication
FXN65_RS25305	COG0359	binds to the 23S rRNA
FXN65_RS25315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FXN65_RS25320	COG0360	Binds together with S18 to 16S ribosomal RNA
FXN65_RS25330	COG0557	exoribonuclease II activity
FXN65_RS25355	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FXN65_RS25365	COG0330	HflC and HflK could
FXN65_RS25370	COG0330	HflC and HflK could
FXN65_RS25375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FXN65_RS25380	COG1923	regulation of RNA biosynthetic process
FXN65_RS25385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FXN65_RS25395	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXN65_RS25400	COG0802	atpase or kinase
FXN65_RS25405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FXN65_RS25405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FXN65_RS25415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FXN65_RS25420	COG1162	GTPase activity
FXN65_RS25425	COG1360	Flagellar Motor Protein
FXN65_RS25445	COG0688	phosphatidylethanolamine metabolic process
FXN65_RS25455	COG5001	Diguanylate cyclase
FXN65_RS25455	COG5002	protein histidine kinase activity
FXN65_RS25495	COG3150	esterase
FXN65_RS25500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXN65_RS25510	COG0494	nUDIX hydrolase
FXN65_RS25525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FXN65_RS25530	COG1538	Outer membrane efflux protein
FXN65_RS25540	COG0446	pyridine nucleotide-disulphide oxidoreductase
FXN65_RS25540	COG1902	pentaerythritol trinitrate reductase activity
FXN65_RS25550	COG1519	Transferase
FXN65_RS25555	COG0583	DNA-binding transcription factor activity
FXN65_RS25570	COG0667	Aldo Keto reductase
FXN65_RS25580	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS25585	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS25590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXN65_RS25590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXN65_RS25595	COG1132	(ABC) transporter
FXN65_RS25610	COG1215	transferase activity, transferring glycosyl groups
FXN65_RS25620	COG1215	transferase activity, transferring glycosyl groups
FXN65_RS25625	COG2192	nodulation
FXN65_RS25650	COG0438	transferase activity, transferring glycosyl groups
FXN65_RS25655	COG0859	PFAM glycosyl transferase family 9
FXN65_RS25660	COG0859	PFAM glycosyl transferase family 9
FXN65_RS25690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN65_RS25700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXN65_RS25705	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS25710	COG3263	regulation of cellular component size
FXN65_RS25715	COG3264	Mechanosensitive ion channel
FXN65_RS25715	COG1196	nuclear chromosome segregation
FXN65_RS25720	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FXN65_RS25725	COG1794	racemase activity, acting on amino acids and derivatives
FXN65_RS25730	COG0730	response to heat
FXN65_RS25735	COG2873	o-acetylhomoserine
FXN65_RS25740	COG3118	belongs to the thioredoxin family
FXN65_RS25750	COG0589	response to stress
FXN65_RS25755	COG1192	Involved in chromosome partitioning
FXN65_RS25770	COG0493	'glutamate synthase
FXN65_RS25775	COG0070	glutamate synthase
FXN65_RS25775	COG0069	glutamate synthase activity
FXN65_RS25775	COG0067	glutamate synthase
FXN65_RS25785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FXN65_RS25790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FXN65_RS25825	COG0281	malic enzyme
FXN65_RS25840	COG0254	rRNA binding
FXN65_RS25845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FXN65_RS25850	COG0018	arginyl-trna synthetase
FXN65_RS25865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FXN65_RS25920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FXN65_RS25925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FXN65_RS25940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN65_RS25955	COG0840	transmembrane signaling receptor activity
FXN65_RS25970	COG0765	amino acid transport
FXN65_RS25980	COG1490	D-aminoacyl-tRNA deacylase activity
FXN65_RS25995	COG1051	belongs to the nudix hydrolase family
FXN65_RS26005	COG2267	carboxylic ester hydrolase activity
FXN65_RS26020	COG2986	histidine ammonia-lyase
FXN65_RS26025	COG0517	IMP dehydrogenase activity
FXN65_RS26025	COG4175	Glycine betaine
FXN65_RS26030	COG4176	ABC-type proline glycine betaine transport system permease component
FXN65_RS26050	COG3314	Sporulation integral membrane protein YlbJ
FXN65_RS26070	COG0402	S-adenosylhomocysteine deaminase activity
FXN65_RS26090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FXN65_RS26115	COG2354	Protein conserved in bacteria
FXN65_RS26120	COG2194	sulfuric ester hydrolase activity
FXN65_RS26170	COG3210	domain, Protein
FXN65_RS26175	COG2831	hemolysin activation secretion protein
FXN65_RS26180	COG1217	gtp-binding protein TYPA
FXN65_RS26185	COG0301	tRNA thio-modification
FXN65_RS26185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN65_RS26195	COG0668	transmembrane transport
FXN65_RS26210	COG3852	Histidine kinase
FXN65_RS26225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FXN65_RS26230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXN65_RS26240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN65_RS26245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FXN65_RS26250	COG4942	peptidase
FXN65_RS26255	COG0793	Belongs to the peptidase S41A family
FXN65_RS26260	COG2861	carbohydrate metabolic process
FXN65_RS26280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FXN65_RS26290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FXN65_RS26295	COG0131	Imidazoleglycerol-phosphate dehydratase
FXN65_RS26310	COG1194	a g-specific adenine glycosylase
FXN65_RS26345	COG4215	(ABC) transporter
FXN65_RS26375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FXN65_RS26380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN65_RS26385	COG0529	Catalyzes the synthesis of activated sulfate
FXN65_RS26495	COG0494	nUDIX hydrolase
FXN65_RS26500	COG1011	Hydrolase
FXN65_RS26505	COG0583	DNA-binding transcription factor activity
FXN65_RS26510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FXN65_RS26530	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FXN65_RS26535	COG0824	Thioesterase
FXN65_RS26540	COG1454	alcohol dehydrogenase
FXN65_RS26545	COG1960	acyl-CoA dehydrogenase activity
FXN65_RS26550	COG1250	3-hydroxyacyl-CoA dehydrogenase
FXN65_RS26550	COG1024	Enoyl-CoA hydratase
FXN65_RS26560	COG0778	Nitroreductase
FXN65_RS26575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXN65_RS26580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXN65_RS26585	COG0189	ligase activity
FXN65_RS26585	COG4067	protein conserved in archaea
FXN65_RS26590	COG0189	ligase activity
FXN65_RS26610	COG2183	response to ionizing radiation
FXN65_RS26645	COG1522	sequence-specific DNA binding
FXN65_RS26655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FXN65_RS26660	COG0330	HflC and HflK could
FXN65_RS26670	COG0484	heat shock protein binding
FXN65_RS26680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS26680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FXN65_RS26690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FXN65_RS26695	COG1178	ABC-type Fe3 transport system permease component
FXN65_RS26705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXN65_RS26710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FXN65_RS26715	COG0006	proline dipeptidase activity
FXN65_RS26720	COG3079	Belongs to the UPF0149 family
FXN65_RS26740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXN65_RS26760	COG0604	alcohol dehydrogenase
FXN65_RS26765	COG0318	PFAM AMP-dependent synthetase and ligase
FXN65_RS26775	COG0154	amidase activity
FXN65_RS26785	COG1177	transmembrane transport
FXN65_RS26790	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN65_RS26795	COG3842	ATPase activity
FXN65_RS26800	COG0583	DNA-binding transcription factor activity
FXN65_RS26810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FXN65_RS26825	COG0248	Ppx GppA phosphatase
FXN65_RS26840	COG0586	Pfam SNARE associated Golgi protein
FXN65_RS26855	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FXN65_RS26860	COG2050	protein possibly involved in aromatic compounds catabolism
FXN65_RS26865	COG1671	Belongs to the UPF0178 family
FXN65_RS26870	COG0672	)-iron permease
FXN65_RS26875	COG1280	lysine exporter protein (LysE YggA)
FXN65_RS26885	COG0488	(ABC) transporter
FXN65_RS26930	COG0181	hydroxymethylbilane synthase activity
FXN65_RS26940	COG0745	RESPONSE REGULATOR receiver
FXN65_RS26940	COG2972	Histidine kinase
FXN65_RS26965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN65_RS26975	COG1965	Belongs to the frataxin family
FXN65_RS26995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXN65_RS27010	COG1011	Hydrolase
FXN65_RS27020	COG0432	Pfam Uncharacterised protein family UPF0047
FXN65_RS27025	COG0004	ammonium transporteR
FXN65_RS27030	COG0347	Belongs to the P(II) protein family
FXN65_RS27040	COG0606	chelatase, subunit chli
FXN65_RS27045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FXN65_RS27050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN65_RS27055	COG0583	DNA-binding transcription factor activity
FXN65_RS27075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FXN65_RS27090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FXN65_RS27095	COG0251	oxidation-reduction process
FXN65_RS27100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS27110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN65_RS27115	COG2814	Major facilitator Superfamily
FXN65_RS27120	COG1012	belongs to the aldehyde dehydrogenase family
FXN65_RS27125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FXN65_RS27135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FXN65_RS27140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FXN65_RS27145	COG0747	negative chemotaxis
FXN65_RS27150	COG2003	Belongs to the UPF0758 family
FXN65_RS27155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXN65_RS27160	COG0756	dUTP diphosphatase activity
FXN65_RS27170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FXN65_RS27175	COG0824	Thioesterase
FXN65_RS27190	COG0708	Exodeoxyribonuclease III
FXN65_RS27200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FXN65_RS27205	COG1561	YicC-like family, N-terminal region
FXN65_RS27215	COG1758	RNA polymerase activity
FXN65_RS27220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN65_RS27240	COG1917	Cupin 2, conserved barrel domain protein
FXN65_RS27240	COG2207	Transcriptional regulator
FXN65_RS27255	COG0848	biopolymer transport protein
FXN65_RS27265	COG0583	DNA-binding transcription factor activity
FXN65_RS27270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FXN65_RS27310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FXN65_RS27330	COG1253	flavin adenine dinucleotide binding
FXN65_RS27335	COG0739	heme binding
FXN65_RS27350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FXN65_RS27355	COG0573	inorganic phosphate transmembrane transporter activity
FXN65_RS27375	COG0477	Major facilitator Superfamily
FXN65_RS27385	COG1136	(ABC) transporter
FXN65_RS27385	COG0577	efflux transmembrane transporter activity
FXN65_RS27390	COG0577	efflux transmembrane transporter activity
FXN65_RS27390	COG1136	(ABC) transporter
FXN65_RS27395	COG1136	(ABC) transporter
FXN65_RS27395	COG0577	efflux transmembrane transporter activity
FXN65_RS27405	COG0676	glucose-6-phosphate 1-epimerase activity
FXN65_RS27435	COG0583	DNA-binding transcription factor activity
FXN65_RS27450	COG2808	Putative FMN-binding domain
FXN65_RS27470	COG1115	amino acid carrier protein
FXN65_RS27475	COG0252	asparaginase activity
FXN65_RS27485	COG2203	Gaf domain
FXN65_RS27485	COG4251	negative regulation of phosphorylation
FXN65_RS27485	COG5001	Diguanylate cyclase
FXN65_RS27485	COG3706	GGDEF domain
FXN65_RS27490	COG0511	ligase activity, forming carbon-carbon bonds
FXN65_RS27490	COG5016	pyruvate
FXN65_RS27495	COG0439	Biotin carboxylase
FXN65_RS27500	COG0583	DNA-binding transcription factor activity
FXN65_RS27515	COG1737	Transcriptional regulator
FXN65_RS27515	COG0837	glucose binding
FXN65_RS27520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXN65_RS27525	COG0826	peptidase U32
FXN65_RS27535	COG0210	DNA helicase
FXN65_RS27555	COG2153	protein acetylation
FXN65_RS27565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FXN65_RS27565	COG4651	solute:proton antiporter activity
FXN65_RS27575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXN65_RS27580	COG0174	glutamine synthetase
FXN65_RS27590	COG1607	acyl-coa hydrolase
FXN65_RS27600	COG2847	Copper chaperone PCu(A)C
FXN65_RS27625	COG4191	Histidine kinase
FXN65_RS27635	COG0477	Major facilitator Superfamily
FXN65_RS27640	COG0523	cobalamin synthesis protein
FXN65_RS27665	COG1469	GTP cyclohydrolase I activity
FXN65_RS27670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FXN65_RS27710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXN65_RS27715	COG1349	DNA-binding transcription factor activity
FXN65_RS27720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXN65_RS27745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXN65_RS27750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FXN65_RS27765	COG3312	ion transport
FXN65_RS27770	COG1475	DNA binding
FXN65_RS27775	COG1192	Involved in chromosome partitioning
FXN65_RS27785	COG0445	tRNA wobble uridine modification
FXN65_RS27790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FXN65_RS27795	COG0706	membrane insertase activity
FXN65_RS27800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FXN65_RS27805	COG0594	ribonuclease P activity
FXN65_RS27810	COG0230	Belongs to the bacterial ribosomal protein bL34 family