locus-tag	class	description
C4J93_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J93_RS00010	COG0592	DNA-directed DNA polymerase activity
C4J93_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J93_RS00020	COG0187	DNA topoisomerase II activity
C4J93_RS00025	COG0745	RESPONSE REGULATOR receiver
C4J93_RS00030	COG5002	protein histidine kinase activity
C4J93_RS00040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4J93_RS00045	COG0751	glycine-tRNA ligase activity
C4J93_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
C4J93_RS00055	COG2818	Glycosylase
C4J93_RS00070	COG0569	domain protein
C4J93_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4J93_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J93_RS00085	COG0242	peptide deformylase activity
C4J93_RS00095	COG0758	DNA mediated transformation
C4J93_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
C4J93_RS00110	COG0408	coproporphyrinogen oxidase activity
C4J93_RS00115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J93_RS00130	COG3119	arylsulfatase activity
C4J93_RS00135	COG0583	DNA-binding transcription factor activity
C4J93_RS00145	COG3734	2-keto-3-deoxy-galactonokinase
C4J93_RS00150	COG0800	Aldolase
C4J93_RS00155	COG4948	Mandelate Racemase Muconate Lactonizing
C4J93_RS00160	COG2271	Major facilitator Superfamily
C4J93_RS00170	COG0159	tryptophan synthase activity
C4J93_RS00190	COG3360	Dodecin
C4J93_RS00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J93_RS00205	COG1764	response to oxidative stress
C4J93_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4J93_RS00240	COG0339	signal peptide processing
C4J93_RS00280	COG0659	secondary active sulfate transmembrane transporter activity
C4J93_RS00290	COG1565	acr, cog1565
C4J93_RS00290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J93_RS00295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J93_RS00300	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4J93_RS00330	COG0109	protoheme IX farnesyltransferase activity
C4J93_RS00345	COG2011	ABC-type metal ion transport system permease component
C4J93_RS00350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J93_RS00365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J93_RS00370	COG1121	(ABC) transporter
C4J93_RS00375	COG0735	belongs to the Fur family
C4J93_RS00380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4J93_RS00400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4J93_RS00415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4J93_RS00430	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J93_RS00435	COG5002	protein histidine kinase activity
C4J93_RS00440	COG2204	response regulator
C4J93_RS00450	COG5487	UPF0391 membrane protein
C4J93_RS00460	COG1301	dicarboxylic acid transport
C4J93_RS00465	COG0700	Nucleoside recognition
C4J93_RS00480	COG1127	ABC transporter
C4J93_RS00485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J93_RS00495	COG0612	Peptidase, M16
C4J93_RS00500	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4J93_RS00505	COG0861	Integral membrane protein TerC family
C4J93_RS00510	COG2851	Citrate transporter
C4J93_RS00540	COG0427	acetyl-CoA hydrolase
C4J93_RS00560	COG0583	DNA-binding transcription factor activity
C4J93_RS00565	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS00610	COG0840	transmembrane signaling receptor activity
C4J93_RS00640	COG3300	MHYT domain
C4J93_RS00640	COG5001	Diguanylate cyclase
C4J93_RS00660	COG2274	protein secretion by the type I secretion system
C4J93_RS00665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS00670	COG2175	clavaminate synthase activity
C4J93_RS00770	COG0529	Catalyzes the synthesis of activated sulfate
C4J93_RS00785	COG1289	transmembrane transporter activity
C4J93_RS00810	COG5339	Protein conserved in bacteria
C4J93_RS00815	COG0457	Tetratricopeptide repeat
C4J93_RS00820	COG1649	PFAM Uncharacterised BCR, COG1649
C4J93_RS00820	COG0726	polysaccharide deacetylase
C4J93_RS00825	COG1215	transferase activity, transferring glycosyl groups
C4J93_RS00910	COG2304	oxidoreductase activity
C4J93_RS00915	COG1595	DNA-templated transcription, initiation
C4J93_RS00940	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS00945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J93_RS00955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J93_RS00965	COG2199	diguanylate cyclase activity
C4J93_RS00985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J93_RS00995	COG4208	sulfate ABC transporter
C4J93_RS01000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4J93_RS01010	COG2351	hydroxyisourate hydrolase activity
C4J93_RS01045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J93_RS01050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS01075	COG4771	TonB-dependent receptor
C4J93_RS01080	COG2807	transmembrane transport
C4J93_RS01105	COG2801	Transposase and inactivated derivatives
C4J93_RS01105	COG3415	Transposase
C4J93_RS01130	COG0765	amino acid transport
C4J93_RS01135	COG0765	amino acid transport
C4J93_RS01140	COG1126	abc transporter atp-binding protein
C4J93_RS01145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS01150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J93_RS01160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS01180	COG2011	ABC-type metal ion transport system permease component
C4J93_RS01185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J93_RS01190	COG1464	Belongs to the NlpA lipoprotein family
C4J93_RS01220	COG1126	abc transporter atp-binding protein
C4J93_RS01225	COG0765	amino acid transport
C4J93_RS01230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS01240	COG1045	serine acetyltransferase
C4J93_RS01245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J93_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS01260	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS01270	COG0667	Aldo Keto reductase
C4J93_RS01275	COG2175	clavaminate synthase activity
C4J93_RS01280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J93_RS01285	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4J93_RS01290	COG4521	taurine ABC transporter
C4J93_RS01295	COG2918	glutathione biosynthetic process
C4J93_RS01305	COG2183	response to ionizing radiation
C4J93_RS01320	COG0189	ligase activity
C4J93_RS01325	COG0189	ligase activity
C4J93_RS01325	COG4067	protein conserved in archaea
C4J93_RS01330	COG2200	EAL domain
C4J93_RS01335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4J93_RS01345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4J93_RS01350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4J93_RS01375	COG2184	nucleotidyltransferase activity
C4J93_RS01390	COG0514	ATP-dependent DNA helicase (RecQ)
C4J93_RS01395	COG0824	Thioesterase
C4J93_RS01405	COG0243	molybdopterin cofactor binding
C4J93_RS01410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4J93_RS01415	COG1652	LysM domain
C4J93_RS01420	COG1011	Hydrolase
C4J93_RS01425	COG0494	nUDIX hydrolase
C4J93_RS01430	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4J93_RS01470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J93_RS01475	COG2957	Belongs to the agmatine deiminase family
C4J93_RS01520	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS01525	COG1309	transcriptional regulator
C4J93_RS01530	COG0583	DNA-binding transcription factor activity
C4J93_RS01580	COG2894	cell division
C4J93_RS01635	COG3210	domain, Protein
C4J93_RS01680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4J93_RS01685	COG1194	a g-specific adenine glycosylase
C4J93_RS01695	COG2223	nitrite transmembrane transporter activity
C4J93_RS01700	COG0131	Imidazoleglycerol-phosphate dehydratase
C4J93_RS01705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4J93_RS01715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4J93_RS01720	COG0107	imidazoleglycerol-phosphate synthase activity
C4J93_RS01730	COG2861	carbohydrate metabolic process
C4J93_RS01735	COG0793	Belongs to the peptidase S41A family
C4J93_RS01740	COG4942	peptidase
C4J93_RS01745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4J93_RS01750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J93_RS01760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4J93_RS01785	COG3852	Histidine kinase
C4J93_RS01805	COG0301	tRNA thio-modification
C4J93_RS01805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J93_RS01810	COG1217	gtp-binding protein TYPA
C4J93_RS01820	COG0058	SHG alpha-glucan phosphorylase activity
C4J93_RS01835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4J93_RS01850	COG0402	S-adenosylhomocysteine deaminase activity
C4J93_RS01855	COG2188	Transcriptional regulator
C4J93_RS01865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4J93_RS01870	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J93_RS01880	COG4176	ABC-type proline glycine betaine transport system permease component
C4J93_RS01885	COG4175	Glycine betaine
C4J93_RS01885	COG0517	IMP dehydrogenase activity
C4J93_RS01890	COG2986	histidine ammonia-lyase
C4J93_RS01895	COG2986	histidine ammonia-lyase
C4J93_RS01900	COG1228	amidohydrolase
C4J93_RS01920	COG1490	D-aminoacyl-tRNA deacylase activity
C4J93_RS01925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J93_RS01930	COG2943	transferase activity, transferring hexosyl groups
C4J93_RS01945	COG0765	amino acid transport
C4J93_RS01950	COG1126	abc transporter atp-binding protein
C4J93_RS01955	COG0840	transmembrane signaling receptor activity
C4J93_RS01960	COG0840	transmembrane signaling receptor activity
C4J93_RS01975	COG1422	Protein of unknown function (DUF1090)
C4J93_RS01980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J93_RS01985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4J93_RS01990	COG0640	Transcriptional regulator
C4J93_RS01995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4J93_RS02005	COG0126	phosphoglycerate kinase activity
C4J93_RS02040	COG1451	nucleotide metabolic process
C4J93_RS02050	COG2153	protein acetylation
C4J93_RS02060	COG1289	transmembrane transporter activity
C4J93_RS02065	COG2081	HI0933 family
C4J93_RS02070	COG0513	Belongs to the DEAD box helicase family
C4J93_RS02075	COG0477	Major facilitator Superfamily
C4J93_RS02100	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J93_RS02105	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS02110	COG1309	transcriptional regulator
C4J93_RS02115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J93_RS02120	COG4175	Glycine betaine
C4J93_RS02135	COG1760	l-serine dehydratase
C4J93_RS02140	COG2814	Major facilitator Superfamily
C4J93_RS02145	COG0583	DNA-binding transcription factor activity
C4J93_RS02160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J93_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS02175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J93_RS02185	COG2226	methyltransferase
C4J93_RS02210	COG2986	histidine ammonia-lyase
C4J93_RS02225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J93_RS02235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J93_RS02240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J93_RS02255	COG1192	Involved in chromosome partitioning
C4J93_RS02265	COG3118	belongs to the thioredoxin family
C4J93_RS02280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4J93_RS02285	COG3264	Mechanosensitive ion channel
C4J93_RS02285	COG1196	nuclear chromosome segregation
C4J93_RS02290	COG3263	regulation of cellular component size
C4J93_RS02310	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS02315	COG0506	proline dehydrogenase activity
C4J93_RS02315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J93_RS02315	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J93_RS02325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J93_RS02340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4J93_RS02345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J93_RS02365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J93_RS02370	COG0859	PFAM glycosyl transferase family 9
C4J93_RS02375	COG0859	PFAM glycosyl transferase family 9
C4J93_RS02380	COG0438	transferase activity, transferring glycosyl groups
C4J93_RS02400	COG0515	serine threonine protein kinase
C4J93_RS02405	COG4772	TonB-dependent receptor
C4J93_RS02415	COG2192	nodulation
C4J93_RS02430	COG0438	transferase activity, transferring glycosyl groups
C4J93_RS02435	COG1215	transferase activity, transferring glycosyl groups
C4J93_RS02445	COG1132	(ABC) transporter
C4J93_RS02450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4J93_RS02450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4J93_RS02455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J93_RS02465	COG0667	Aldo Keto reductase
C4J93_RS02480	COG0583	DNA-binding transcription factor activity
C4J93_RS02485	COG1519	Transferase
C4J93_RS02490	COG1538	Outer membrane efflux protein
C4J93_RS02495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4J93_RS02515	COG0494	nUDIX hydrolase
C4J93_RS02525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J93_RS02545	COG3150	esterase
C4J93_RS02580	COG0688	phosphatidylethanolamine metabolic process
C4J93_RS02610	COG1162	GTPase activity
C4J93_RS02615	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4J93_RS02620	COG2860	membrane
C4J93_RS02630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4J93_RS02630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4J93_RS02635	COG0802	atpase or kinase
C4J93_RS02640	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J93_RS02645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4J93_RS02650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4J93_RS02655	COG1923	regulation of RNA biosynthetic process
C4J93_RS02660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4J93_RS02665	COG0330	HflC and HflK could
C4J93_RS02670	COG0330	HflC and HflK could
C4J93_RS02675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4J93_RS02680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4J93_RS02690	COG1178	ABC-type Fe3 transport system permease component
C4J93_RS02695	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J93_RS02710	COG0557	exoribonuclease II activity
C4J93_RS02715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J93_RS02720	COG0360	Binds together with S18 to 16S ribosomal RNA
C4J93_RS02725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J93_RS02735	COG0359	binds to the 23S rRNA
C4J93_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
C4J93_RS02750	COG1032	radical SAM domain protein
C4J93_RS02770	COG2307	Protein conserved in bacteria
C4J93_RS02770	COG2308	Evidence 4 Homologs of previously reported genes of
C4J93_RS02795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J93_RS02800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4J93_RS02805	COG0583	DNA-binding transcription factor activity
C4J93_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS02815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS02825	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS02850	COG4221	oxidoreductase activity
C4J93_RS02870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4J93_RS02875	COG0830	nickel cation binding
C4J93_RS02880	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4J93_RS02885	COG0791	NLP P60 protein
C4J93_RS02890	COG1309	transcriptional regulator
C4J93_RS02900	COG2982	Protein involved in outer membrane biogenesis
C4J93_RS02920	COG0443	Heat shock 70 kDa protein
C4J93_RS02925	COG0484	heat shock protein binding
C4J93_RS02930	COG0804	urea catabolic process
C4J93_RS02935	COG0832	Belongs to the urease beta subunit family
C4J93_RS02950	COG0831	urea catabolic process
C4J93_RS02955	COG0829	nickel cation binding
C4J93_RS02965	COG0411	ABC transporter
C4J93_RS03020	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J93_RS03075	COG2095	MarC family integral membrane protein
C4J93_RS03095	COG3415	Transposase
C4J93_RS03095	COG2801	Transposase and inactivated derivatives
C4J93_RS03105	COG0151	Belongs to the GarS family
C4J93_RS03110	COG0138	bifunctional purine biosynthesis protein purh
C4J93_RS03120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J93_RS03135	COG2264	protein methyltransferase activity
C4J93_RS03150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J93_RS03175	COG0023	Translation Initiation Factor
C4J93_RS03180	COG1166	arginine decarboxylase activity
C4J93_RS03185	COG0534	Mate efflux family protein
C4J93_RS03190	COG2373	Large extracellular alpha-helical protein
C4J93_RS03200	COG4953	penicillin-binding protein 1C
C4J93_RS03210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J93_RS03280	COG4964	Belongs to the GSP D family
C4J93_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS03335	COG2217	Heavy metal translocating P-type atpase
C4J93_RS03355	COG2814	Major facilitator Superfamily
C4J93_RS03360	COG0604	alcohol dehydrogenase
C4J93_RS03365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4J93_RS03370	COG0583	DNA-binding transcription factor activity
C4J93_RS03380	COG0477	Major facilitator Superfamily
C4J93_RS03385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J93_RS03390	COG0387	Pfam Sodium calcium exchanger
C4J93_RS03410	COG1309	transcriptional regulator
C4J93_RS03415	COG2233	PERMEase
C4J93_RS03465	COG2995	paraquat-inducible protein a
C4J93_RS03470	COG2995	paraquat-inducible protein a
C4J93_RS03475	COG3008	intermembrane lipid transfer
C4J93_RS03500	COG0456	acetyltransferase
C4J93_RS03510	COG0288	reversible hydration of carbon dioxide
C4J93_RS03535	COG2031	fatty acid transporter
C4J93_RS03540	COG0477	Major facilitator Superfamily
C4J93_RS03600	COG0405	Gamma-glutamyltransferase
C4J93_RS03635	COG1157	protein secretion by the type III secretion system
C4J93_RS03660	COG4794	Type iii secretion
C4J93_RS03670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J93_RS03705	COG4669	(LipO)protein
C4J93_RS03730	COG0193	aminoacyl-tRNA hydrolase activity
C4J93_RS03735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4J93_RS03740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J93_RS03750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4J93_RS03755	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4J93_RS03765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4J93_RS03770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4J93_RS03780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4J93_RS03805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J93_RS03820	COG4221	oxidoreductase activity
C4J93_RS03825	COG0415	Belongs to the DNA photolyase family
C4J93_RS03830	COG0789	Transcriptional regulator
C4J93_RS03845	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4J93_RS03850	COG1090	epimerase
C4J93_RS03855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4J93_RS03865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J93_RS03875	COG0175	sulfate reduction
C4J93_RS03885	COG0204	Acyl-transferase
C4J93_RS03890	COG0280	phosphate acetyltransferase
C4J93_RS03890	COG0857	belongs to the CobB CobQ family
C4J93_RS03905	COG0268	Binds directly to 16S ribosomal RNA
C4J93_RS03915	COG0196	riboflavin kinase activity
C4J93_RS03920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4J93_RS03925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J93_RS03930	COG1047	Peptidyl-prolyl cis-trans
C4J93_RS03935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4J93_RS03965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS03990	COG0542	response to heat
C4J93_RS04015	COG1252	NADH dehydrogenase
C4J93_RS04040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4J93_RS04045	COG0237	dephospho-CoA kinase activity
C4J93_RS04085	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J93_RS04095	COG0840	transmembrane signaling receptor activity
C4J93_RS04105	COG0084	hydrolase, TatD family'
C4J93_RS04110	COG1609	Transcriptional regulator
C4J93_RS04120	COG1105	Belongs to the carbohydrate kinase PfkB family
C4J93_RS04125	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4J93_RS04125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J93_RS04125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J93_RS04135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4J93_RS04140	COG4774	siderophore transport
C4J93_RS04145	COG3128	pkhd-type hydroxylase
C4J93_RS04165	COG0019	diaminopimelate decarboxylase activity
C4J93_RS04190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4J93_RS04205	COG4608	Belongs to the ABC transporter superfamily
C4J93_RS04210	COG0444	Belongs to the ABC transporter superfamily
C4J93_RS04215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J93_RS04220	COG0601	transmembrane transport
C4J93_RS04225	COG0747	negative chemotaxis
C4J93_RS04235	COG0747	negative chemotaxis
C4J93_RS04240	COG0747	negative chemotaxis
C4J93_RS04245	COG0747	negative chemotaxis
C4J93_RS04265	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4J93_RS04270	COG4178	(ABC) transporter
C4J93_RS04285	COG0180	Tryptophanyl-tRNA synthetase
C4J93_RS04290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J93_RS04300	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS04310	COG0667	Aldo Keto reductase
C4J93_RS04315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4J93_RS04320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4J93_RS04325	COG0723	plastoquinol--plastocyanin reductase activity
C4J93_RS04330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J93_RS04335	COG2857	Cytochrome c1
C4J93_RS04340	COG0625	glutathione transferase activity
C4J93_RS04345	COG2969	positive regulation of protein catabolic process
C4J93_RS04350	COG2186	Transcriptional regulator
C4J93_RS04360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J93_RS04370	COG2271	Major facilitator Superfamily
C4J93_RS04375	COG2721	sulfolactate sulfo-lyase activity
C4J93_RS04400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J93_RS04410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J93_RS04415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J93_RS04420	COG0154	amidase activity
C4J93_RS04425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J93_RS04430	COG1077	Cell shape determining protein MreB Mrl
C4J93_RS04435	COG1792	Involved in formation and maintenance of cell shape
C4J93_RS04445	COG0424	maF-like protein
C4J93_RS04450	COG1530	ribonuclease E activity
C4J93_RS04460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J93_RS04465	COG0312	modulator of DNA gyrase
C4J93_RS04470	COG3028	Belongs to the UPF0307 family
C4J93_RS04475	COG0312	modulator of DNA gyrase
C4J93_RS04505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J93_RS04510	COG1660	Displays ATPase and GTPase activities
C4J93_RS04520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4J93_RS04525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4J93_RS04530	COG1137	ATPase activity
C4J93_RS04535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4J93_RS04545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4J93_RS04555	COG1127	ABC transporter
C4J93_RS04560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J93_RS04565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4J93_RS04585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J93_RS04595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4J93_RS04600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4J93_RS04605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J93_RS04615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4J93_RS04620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4J93_RS04675	COG2135	peptidase activity
C4J93_RS04680	COG0501	Belongs to the peptidase M48B family
C4J93_RS04685	COG2119	membrane
C4J93_RS04690	COG2813	Specifically methylates the guanine in position
C4J93_RS04695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J93_RS04700	COG1280	lysine exporter protein (LysE YggA)
C4J93_RS04705	COG0318	PFAM AMP-dependent synthetase and ligase
C4J93_RS04730	COG3008	intermembrane lipid transfer
C4J93_RS04735	COG2995	paraquat-inducible protein a
C4J93_RS04750	COG2885	chlorophyll binding
C4J93_RS04755	COG2823	Periplasmic or secreted lipoprotein
C4J93_RS04760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4J93_RS04765	COG0792	nuclease activity
C4J93_RS04785	COG2001	Belongs to the MraZ family
C4J93_RS04790	COG0275	rRNA processing
C4J93_RS04805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J93_RS04810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4J93_RS04815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J93_RS04820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J93_RS04825	COG0772	Belongs to the SEDS family
C4J93_RS04830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J93_RS04835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J93_RS04840	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J93_RS04855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4J93_RS04860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4J93_RS04865	COG4251	negative regulation of phosphorylation
C4J93_RS04865	COG3706	GGDEF domain
C4J93_RS04865	COG5001	Diguanylate cyclase
C4J93_RS04865	COG2203	Gaf domain
C4J93_RS04875	COG5002	protein histidine kinase activity
C4J93_RS04900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS04915	COG0784	Response regulator, receiver
C4J93_RS04915	COG0835	chemotaxis
C4J93_RS04925	COG0583	DNA-binding transcription factor activity
C4J93_RS04945	COG1566	PFAM secretion protein HlyD family protein
C4J93_RS04955	COG0300	oxidoreductase activity
C4J93_RS04970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J93_RS04970	COG0662	Cupin 2, conserved barrel domain protein
C4J93_RS04985	COG1696	Membrane protein involved in D-alanine export
C4J93_RS05000	COG3420	alginic acid biosynthetic process
C4J93_RS05010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4J93_RS05015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS05025	COG1215	transferase activity, transferring glycosyl groups
C4J93_RS05035	COG3022	response to hydroperoxide
C4J93_RS05045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4J93_RS05055	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J93_RS05060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4J93_RS05075	COG3209	COG3209 Rhs family protein
C4J93_RS05080	COG0513	Belongs to the DEAD box helicase family
C4J93_RS05090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS05095	COG4597	amino acid ABC transporter
C4J93_RS05100	COG0765	amino acid transport
C4J93_RS05105	COG1126	abc transporter atp-binding protein
C4J93_RS05120	COG2186	Transcriptional regulator
C4J93_RS05125	COG2807	transmembrane transport
C4J93_RS05130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS05130	COG2205	protein histidine kinase activity
C4J93_RS05145	COG2827	Endonuclease containing a URI domain
C4J93_RS05150	COG4774	siderophore transport
C4J93_RS05165	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4J93_RS05170	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J93_RS05190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4J93_RS05210	COG1760	l-serine dehydratase
C4J93_RS05215	COG0583	DNA-binding transcription factor activity
C4J93_RS05225	COG0477	Major facilitator Superfamily
C4J93_RS05230	COG0583	DNA-binding transcription factor activity
C4J93_RS05235	COG4772	TonB-dependent receptor
C4J93_RS05240	COG3712	iron ion homeostasis
C4J93_RS05245	COG1595	DNA-templated transcription, initiation
C4J93_RS05280	COG3081	Nucleoid-associated protein
C4J93_RS05290	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4J93_RS05295	COG0525	valine-tRNA ligase activity
C4J93_RS05310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4J93_RS05315	COG0795	lipopolysaccharide-transporting ATPase activity
C4J93_RS05320	COG0795	lipopolysaccharide-transporting ATPase activity
C4J93_RS05325	COG0481	GTPase activity
C4J93_RS05330	COG0681	Belongs to the peptidase S26 family
C4J93_RS05335	COG0571	ribonuclease III activity
C4J93_RS05340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4J93_RS05345	COG1381	Involved in DNA repair and RecF pathway recombination
C4J93_RS05350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4J93_RS05360	COG0590	tRNA wobble adenosine to inosine editing
C4J93_RS05365	COG0500	methyltransferase
C4J93_RS05370	COG2226	methyltransferase
C4J93_RS05380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J93_RS05405	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS05410	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS05420	COG0523	cobalamin synthesis protein
C4J93_RS05440	COG4206	TonB-dependent receptor
C4J93_RS05445	COG4628	conserved protein (DUF2132)
C4J93_RS05455	COG2375	cellular response to nickel ion
C4J93_RS05460	COG1695	Transcriptional regulator
C4J93_RS05515	COG1113	amino acid transport
C4J93_RS05525	COG0069	glutamate synthase activity
C4J93_RS05540	COG5002	protein histidine kinase activity
C4J93_RS05545	COG1858	cytochrome C peroxidase
C4J93_RS05560	COG0494	nUDIX hydrolase
C4J93_RS05580	COG3415	Transposase
C4J93_RS05580	COG2801	Transposase and inactivated derivatives
C4J93_RS05585	COG0583	DNA-binding transcription factor activity
C4J93_RS05610	COG2076	Multidrug Resistance protein
C4J93_RS05625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J93_RS05640	COG4191	Histidine kinase
C4J93_RS05645	COG2204	response regulator
C4J93_RS05665	COG1126	abc transporter atp-binding protein
C4J93_RS05670	COG0765	amino acid transport
C4J93_RS05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS05695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J93_RS05705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4J93_RS05710	COG3842	ATPase activity
C4J93_RS05715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4J93_RS05725	COG0243	molybdopterin cofactor binding
C4J93_RS05730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4J93_RS05745	COG0450	alkyl hydroperoxide reductase
C4J93_RS05750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J93_RS05755	COG0418	dihydroorotase activity
C4J93_RS05765	COG0137	argininosuccinate synthase activity
C4J93_RS05770	COG2197	response regulator
C4J93_RS05780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4J93_RS05785	COG2878	Part of a membrane complex involved in electron transport
C4J93_RS05790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J93_RS05790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J93_RS05795	COG0489	protein tyrosine kinase activity
C4J93_RS05805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4J93_RS05810	COG0582	viral genome integration into host DNA
C4J93_RS05835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C4J93_RS06030	COG3179	chitinase
C4J93_RS06045	COG2135	peptidase activity
C4J93_RS06165	COG3179	chitinase
C4J93_RS06175	COG1546	Belongs to the CinA family
C4J93_RS06180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4J93_RS06185	COG2137	regulation of response to DNA damage stimulus
C4J93_RS06200	COG3148	PFAM DTW domain containing protein
C4J93_RS06215	COG0583	DNA-binding transcription factor activity
C4J93_RS06230	COG4807	Protein conserved in bacteria
C4J93_RS06240	COG0519	Catalyzes the synthesis of GMP from XMP
C4J93_RS06245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J93_RS06250	COG3158	transport of potassium into the cell
C4J93_RS06255	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS06265	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J93_RS06285	COG0457	Tetratricopeptide repeat
C4J93_RS06285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J93_RS06300	COG2201	protein-glutamate methylesterase activity
C4J93_RS06305	COG3706	GGDEF domain
C4J93_RS06305	COG2203	Gaf domain
C4J93_RS06305	COG5001	Diguanylate cyclase
C4J93_RS06305	COG4251	negative regulation of phosphorylation
C4J93_RS06315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4J93_RS06330	COG1073	alpha beta
C4J93_RS06350	COG2885	chlorophyll binding
C4J93_RS06365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4J93_RS06370	COG0563	adenylate kinase activity
C4J93_RS06375	COG1214	PFAM Peptidase M22, glycoprotease
C4J93_RS06385	COG1801	Protein of unknown function DUF72
C4J93_RS06405	COG0742	ribosomal rna small subunit methyltransferase
C4J93_RS06415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS06440	COG2937	Belongs to the GPAT DAPAT family
C4J93_RS06455	COG2226	methyltransferase
C4J93_RS06460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J93_RS06465	COG1215	transferase activity, transferring glycosyl groups
C4J93_RS06470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4J93_RS06475	COG2166	iron-sulfur cluster assembly
C4J93_RS06480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J93_RS06485	COG2171	N-acyltransferase activity
C4J93_RS06490	COG1393	Belongs to the ArsC family
C4J93_RS06495	COG0582	viral genome integration into host DNA
C4J93_RS06695	COG1802	Transcriptional regulator
C4J93_RS06695	COG4626	Terminase
C4J93_RS06805	COG3773	Cell wall hydrolase
C4J93_RS06805	COG3409	Peptidoglycan-binding domain 1 protein
C4J93_RS06820	COG0025	NhaP-type Na H and K H
C4J93_RS06845	COG0052	Belongs to the universal ribosomal protein uS2 family
C4J93_RS06850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4J93_RS06855	COG0528	UMP kinase activity
C4J93_RS06860	COG0233	cytoplasmic translational termination
C4J93_RS06865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J93_RS06875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4J93_RS06895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J93_RS06900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J93_RS06905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J93_RS06910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J93_RS06915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4J93_RS06920	COG0587	DNA-directed DNA polymerase activity
C4J93_RS06925	COG0825	malonyl-CoA metabolic process
C4J93_RS06930	COG0037	tRNA processing
C4J93_RS06935	COG0504	CTP synthase activity
C4J93_RS06940	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4J93_RS06945	COG0148	phosphopyruvate hydratase activity
C4J93_RS06955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4J93_RS06965	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4J93_RS06970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4J93_RS06975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4J93_RS06985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4J93_RS06990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4J93_RS07005	COG1278	Cold shock
C4J93_RS07010	COG0717	Belongs to the dCTP deaminase family
C4J93_RS07025	COG1201	RNA secondary structure unwinding
C4J93_RS07040	COG4160	amino acid transport
C4J93_RS07055	COG1793	dna ligase
C4J93_RS07075	COG0653	protein targeting
C4J93_RS07085	COG3012	SEC-C Motif Domain Protein
C4J93_RS07105	COG1199	ATP-dependent helicase activity
C4J93_RS07115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J93_RS07125	COG0259	pyridoxamine-phosphate oxidase activity
C4J93_RS07135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J93_RS07145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4J93_RS07160	COG0583	DNA-binding transcription factor activity
C4J93_RS07175	COG3220	belongs to the UPF0276 family
C4J93_RS07225	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4J93_RS07235	COG2271	Major facilitator Superfamily
C4J93_RS07240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J93_RS07255	COG0306	phosphate transporter
C4J93_RS07265	COG1414	Transcriptional regulator
C4J93_RS07270	COG2814	Major facilitator Superfamily
C4J93_RS07280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J93_RS07285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4J93_RS07290	COG0183	Belongs to the thiolase family
C4J93_RS07295	COG3485	protocatechuate 3,4-dioxygenase
C4J93_RS07300	COG3485	protocatechuate 3,4-dioxygenase
C4J93_RS07305	COG0477	Major facilitator Superfamily
C4J93_RS07315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J93_RS07320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J93_RS07345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS07350	COG1309	transcriptional regulator
C4J93_RS07355	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS07395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J93_RS07440	COG1454	alcohol dehydrogenase
C4J93_RS07450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J93_RS07500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J93_RS07515	COG2267	carboxylic ester hydrolase activity
C4J93_RS07545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J93_RS07575	COG0642	Histidine kinase
C4J93_RS07585	COG0354	folic acid binding
C4J93_RS07590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4J93_RS07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J93_RS07630	COG0425	Belongs to the sulfur carrier protein TusA family
C4J93_RS07635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4J93_RS07645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J93_RS07650	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4J93_RS07655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J93_RS07660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4J93_RS07700	COG0583	DNA-binding transcription factor activity
C4J93_RS07725	COG2807	transmembrane transport
C4J93_RS07730	COG2910	NAD(P)H-binding
C4J93_RS07740	COG0583	DNA-binding transcription factor activity
C4J93_RS07785	COG3100	YcgL domain-containing protein
C4J93_RS07790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J93_RS07800	COG2983	Belongs to the UPF0260 family
C4J93_RS07840	COG1770	oligopeptidase
C4J93_RS07850	COG0121	glutamine amidotransferase
C4J93_RS07860	COG0583	DNA-binding transcription factor activity
C4J93_RS07865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4J93_RS07870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4J93_RS07875	COG1984	allophanate hydrolase subunit 2
C4J93_RS07885	COG0542	response to heat
C4J93_RS07895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J93_RS07910	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4J93_RS07915	COG0425	Belongs to the sulfur carrier protein TusA family
C4J93_RS07925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J93_RS07930	COG1132	(ABC) transporter
C4J93_RS07935	COG0741	lytic transglycosylase activity
C4J93_RS07940	COG0488	(ABC) transporter
C4J93_RS07945	COG0589	response to stress
C4J93_RS07955	COG1024	Enoyl-CoA hydratase
C4J93_RS07955	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J93_RS07960	COG0183	Belongs to the thiolase family
C4J93_RS08010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J93_RS08020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4J93_RS08030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J93_RS08035	COG0584	glycerophosphoryl diester phosphodiesterase
C4J93_RS08045	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J93_RS08050	COG1136	(ABC) transporter
C4J93_RS08055	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J93_RS08075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J93_RS08075	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J93_RS08090	COG2853	Lipoprotein
C4J93_RS08105	COG2204	response regulator
C4J93_RS08120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J93_RS08125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J93_RS08155	COG4104	PAAR repeat-containing protein
C4J93_RS08180	COG2814	Major facilitator Superfamily
C4J93_RS08185	COG0579	oxidoreductase
C4J93_RS08190	COG0583	DNA-binding transcription factor activity
C4J93_RS08215	COG1611	Belongs to the LOG family
C4J93_RS08225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4J93_RS08240	COG0583	DNA-binding transcription factor activity
C4J93_RS08245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J93_RS08250	COG0583	DNA-binding transcription factor activity
C4J93_RS08255	COG2814	Major facilitator Superfamily
C4J93_RS08265	COG2233	PERMEase
C4J93_RS08270	COG2267	carboxylic ester hydrolase activity
C4J93_RS08275	COG2197	response regulator
C4J93_RS08280	COG0596	Alpha beta hydrolase
C4J93_RS08290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J93_RS08295	COG0444	Belongs to the ABC transporter superfamily
C4J93_RS08305	COG0747	negative chemotaxis
C4J93_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS08315	COG0546	phosphoglycolate phosphatase activity
C4J93_RS08320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J93_RS08325	COG0402	S-adenosylhomocysteine deaminase activity
C4J93_RS08330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4J93_RS08340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4J93_RS08350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J93_RS08355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J93_RS08360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4J93_RS08375	COG0776	regulation of translation
C4J93_RS08400	COG1216	Glycosyl transferase, family 2
C4J93_RS08440	COG1555	photosystem II stabilization
C4J93_RS08465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J93_RS08475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J93_RS08480	COG2205	protein histidine kinase activity
C4J93_RS08485	COG0745	RESPONSE REGULATOR receiver
C4J93_RS08525	COG3209	COG3209 Rhs family protein
C4J93_RS08535	COG0084	hydrolase, TatD family'
C4J93_RS08540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J93_RS08565	COG1131	(ABC) transporter
C4J93_RS08575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J93_RS08580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4J93_RS08585	COG4181	ATPase activity
C4J93_RS08630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4J93_RS08650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J93_RS08665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4J93_RS08675	COG1764	response to oxidative stress
C4J93_RS08680	COG1846	Transcriptional regulator
C4J93_RS08685	COG0583	DNA-binding transcription factor activity
C4J93_RS08695	COG0583	DNA-binding transcription factor activity
C4J93_RS08705	COG3214	Protein conserved in bacteria
C4J93_RS08710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J93_RS08730	COG1024	Enoyl-CoA hydratase
C4J93_RS08730	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J93_RS08745	COG3384	dioxygenase
C4J93_RS08750	COG0500	methyltransferase
C4J93_RS08755	COG0501	Belongs to the peptidase M48B family
C4J93_RS08760	COG0436	Aminotransferase
C4J93_RS08765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J93_RS08770	COG0386	Belongs to the glutathione peroxidase family
C4J93_RS08775	COG0784	Response regulator, receiver
C4J93_RS08775	COG2205	protein histidine kinase activity
C4J93_RS08775	COG5002	protein histidine kinase activity
C4J93_RS08785	COG1956	GAF domain-containing protein
C4J93_RS08790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS08790	COG2205	protein histidine kinase activity
C4J93_RS08795	COG2197	response regulator
C4J93_RS08825	COG0004	ammonium transporteR
C4J93_RS08840	COG0564	pseudouridine synthase activity
C4J93_RS08850	COG0746	molybdenum cofactor guanylyltransferase activity
C4J93_RS08855	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4J93_RS08860	COG0303	'Molybdopterin
C4J93_RS08875	COG3237	CsbD-like
C4J93_RS08880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J93_RS08890	COG4133	protoheme IX ABC transporter activity
C4J93_RS08910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4J93_RS08915	COG1138	Cytochrome C-type biogenesis protein
C4J93_RS08925	COG3088	subunit of a heme lyase
C4J93_RS08930	COG4235	cytochrome complex assembly
C4J93_RS08940	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4J93_RS08955	COG2814	Major facilitator Superfamily
C4J93_RS08960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J93_RS08965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J93_RS08975	COG0469	pyruvate kinase activity
C4J93_RS08985	COG2084	Dehydrogenase
C4J93_RS08990	COG3622	Belongs to the hyi family
C4J93_RS08995	COG3960	tartronate-semialdehyde synthase activity
C4J93_RS09005	COG1309	transcriptional regulator
C4J93_RS09010	COG2354	Protein conserved in bacteria
C4J93_RS09015	COG2853	Lipoprotein
C4J93_RS09035	COG2113	Glycine betaine
C4J93_RS09040	COG3162	membrane
C4J93_RS09045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J93_RS09055	COG2009	succinate dehydrogenase
C4J93_RS09060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4J93_RS09065	COG1053	succinate dehydrogenase
C4J93_RS09070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J93_RS09085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J93_RS09090	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J93_RS09125	COG0326	Molecular chaperone. Has ATPase activity
C4J93_RS09135	COG1741	Belongs to the pirin family
C4J93_RS09160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J93_RS09165	COG5002	protein histidine kinase activity
C4J93_RS09165	COG2205	protein histidine kinase activity
C4J93_RS09165	COG0784	Response regulator, receiver
C4J93_RS09180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J93_RS09215	COG0628	permease
C4J93_RS09230	COG0284	orotidine-5'-phosphate decarboxylase activity
C4J93_RS09235	COG2130	NADP-dependent
C4J93_RS09250	COG0840	transmembrane signaling receptor activity
C4J93_RS09255	COG2267	carboxylic ester hydrolase activity
C4J93_RS09305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J93_RS09320	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS09330	COG0625	glutathione transferase activity
C4J93_RS09335	COG1131	(ABC) transporter
C4J93_RS09340	COG0842	Transport permease protein
C4J93_RS09365	COG2076	Multidrug Resistance protein
C4J93_RS09370	COG0385	Bile acid
C4J93_RS09375	COG2974	May be involved in recombination
C4J93_RS09405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J93_RS09410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J93_RS09435	COG2010	Cytochrome c
C4J93_RS09440	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J93_RS09460	COG2200	EAL domain
C4J93_RS09475	COG3842	ATPase activity
C4J93_RS09510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J93_RS09545	COG1509	lysine 2,3-aminomutase activity
C4J93_RS09550	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J93_RS09575	COG3829	transcription factor binding
C4J93_RS09600	COG5006	permease, DMT superfamily
C4J93_RS09635	COG0768	penicillin binding
C4J93_RS09655	COG0417	DNA replication proofreading
C4J93_RS09675	COG0728	peptidoglycan biosynthetic process
C4J93_RS09715	COG0463	Glycosyl transferase, family 2
C4J93_RS09735	COG4977	sequence-specific DNA binding
C4J93_RS09740	COG0596	Alpha beta hydrolase
C4J93_RS09745	COG3387	PFAM Glycoside hydrolase 15-related
C4J93_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS09770	COG2223	nitrite transmembrane transporter activity
C4J93_RS09790	COG3675	Pfam Lipase (class 3)
C4J93_RS09795	COG0402	S-adenosylhomocysteine deaminase activity
C4J93_RS09800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J93_RS09805	COG0720	synthase
C4J93_RS09840	COG0840	transmembrane signaling receptor activity
C4J93_RS09845	COG2056	Na+-H+ antiporter family
C4J93_RS09855	COG0826	peptidase U32
C4J93_RS09860	COG0628	permease
C4J93_RS09875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J93_RS09880	COG3132	Protein of unknown function, DUF480
C4J93_RS09890	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4J93_RS09895	COG0583	DNA-binding transcription factor activity
C4J93_RS09905	COG1253	flavin adenine dinucleotide binding
C4J93_RS09910	COG0709	Synthesizes selenophosphate from selenide and ATP
C4J93_RS09915	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4J93_RS09920	COG0701	Predicted permease
C4J93_RS09930	COG0625	glutathione transferase activity
C4J93_RS09935	COG0384	phenazine biosynthesis protein PhzF
C4J93_RS09940	COG0113	porphobilinogen synthase activity
C4J93_RS09970	COG3209	COG3209 Rhs family protein
C4J93_RS09990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J93_RS09995	COG0583	DNA-binding transcription factor activity
C4J93_RS10005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4J93_RS10010	COG0517	IMP dehydrogenase activity
C4J93_RS10015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J93_RS10020	COG0477	Major facilitator Superfamily
C4J93_RS10035	COG0174	glutamine synthetase
C4J93_RS10060	COG2814	Major facilitator Superfamily
C4J93_RS10090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J93_RS10100	COG2197	response regulator
C4J93_RS10105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS10105	COG2205	protein histidine kinase activity
C4J93_RS10115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4J93_RS10120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J93_RS10135	COG2197	response regulator
C4J93_RS10140	COG0322	excinuclease ABC activity
C4J93_RS10155	COG0582	viral genome integration into host DNA
C4J93_RS10345	COG2003	Belongs to the UPF0758 family
C4J93_RS10360	COG3620	sequence-specific DNA binding
C4J93_RS10370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J93_RS10425	COG3038	cytochrome b561
C4J93_RS10430	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS10445	COG0840	transmembrane signaling receptor activity
C4J93_RS10475	COG0028	Belongs to the TPP enzyme family
C4J93_RS10480	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS10505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J93_RS10515	COG2207	Transcriptional regulator
C4J93_RS10535	COG5002	protein histidine kinase activity
C4J93_RS10540	COG0745	RESPONSE REGULATOR receiver
C4J93_RS10560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS10570	COG2814	Major facilitator Superfamily
C4J93_RS10580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J93_RS10640	COG2207	Transcriptional regulator
C4J93_RS10680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J93_RS10730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J93_RS10735	COG0457	Tetratricopeptide repeat
C4J93_RS10735	COG3710	Transcriptional regulator
C4J93_RS10780	COG2197	response regulator
C4J93_RS10795	COG2197	response regulator
C4J93_RS10825	COG3121	Chaperone
C4J93_RS10830	COG3188	usher protein
C4J93_RS10850	COG3121	Chaperone
C4J93_RS10875	COG0531	amino acid
C4J93_RS10885	COG2201	protein-glutamate methylesterase activity
C4J93_RS10890	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4J93_RS10900	COG0835	chemotaxis
C4J93_RS10910	COG0643	Histidine kinase
C4J93_RS10910	COG2198	Histidine kinase
C4J93_RS10920	COG0745	RESPONSE REGULATOR receiver
C4J93_RS10935	COG2706	6-phosphogluconolactonase activity
C4J93_RS10955	COG0583	DNA-binding transcription factor activity
C4J93_RS10965	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS10980	COG3546	catalase activity
C4J93_RS10985	COG3685	Protein conserved in bacteria
C4J93_RS10990	COG0784	Response regulator, receiver
C4J93_RS10990	COG4191	Histidine kinase
C4J93_RS11005	COG1845	cytochrome c oxidase, subunit III
C4J93_RS11015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J93_RS11060	COG3729	General stress protein
C4J93_RS11065	COG3706	GGDEF domain
C4J93_RS11065	COG2203	Gaf domain
C4J93_RS11065	COG5001	Diguanylate cyclase
C4J93_RS11065	COG4251	negative regulation of phosphorylation
C4J93_RS11090	COG2323	membrane
C4J93_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS11130	COG1546	Belongs to the CinA family
C4J93_RS11130	COG1058	Belongs to the CinA family
C4J93_RS11155	COG2080	2 iron, 2 sulfur cluster binding
C4J93_RS11160	COG0583	DNA-binding transcription factor activity
C4J93_RS11190	COG0019	diaminopimelate decarboxylase activity
C4J93_RS11195	COG1609	Transcriptional regulator
C4J93_RS11210	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J93_RS11220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J93_RS11230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J93_RS11250	COG2194	sulfuric ester hydrolase activity
C4J93_RS11255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J93_RS11260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4J93_RS11265	COG0561	phosphatase activity
C4J93_RS11345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J93_RS11355	COG2233	PERMEase
C4J93_RS11375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J93_RS11385	COG1609	Transcriptional regulator
C4J93_RS11425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS11430	COG0745	RESPONSE REGULATOR receiver
C4J93_RS11435	COG2205	protein histidine kinase activity
C4J93_RS11445	COG0730	response to heat
C4J93_RS11455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J93_RS11460	COG0024	Methionine aminopeptidase
C4J93_RS11485	COG1070	Carbohydrate kinase
C4J93_RS11505	COG1175	transmembrane transport
C4J93_RS11560	COG1538	Outer membrane efflux protein
C4J93_RS11575	COG4214	carbohydrate transport
C4J93_RS11580	COG1129	ABC transporter
C4J93_RS11585	COG4213	ABC transporter substrate-binding protein
C4J93_RS11590	COG2115	Belongs to the xylose isomerase family
C4J93_RS11595	COG1609	Transcriptional regulator
C4J93_RS11595	COG2207	Transcriptional regulator
C4J93_RS11615	COG3781	membrane
C4J93_RS11630	COG0640	Transcriptional regulator
C4J93_RS11635	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS11645	COG1609	Transcriptional regulator
C4J93_RS11675	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS11685	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS11700	COG2207	Transcriptional regulator
C4J93_RS11710	COG0625	glutathione transferase activity
C4J93_RS11725	COG0673	inositol 2-dehydrogenase activity
C4J93_RS11760	COG1968	undecaprenyl-diphosphatase activity
C4J93_RS11775	COG1309	transcriptional regulator
C4J93_RS11785	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS11790	COG3321	synthase
C4J93_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS11790	COG0604	alcohol dehydrogenase
C4J93_RS11800	COG0583	DNA-binding transcription factor activity
C4J93_RS11825	COG1064	alcohol dehydrogenase
C4J93_RS11830	COG2801	Transposase and inactivated derivatives
C4J93_RS11830	COG3415	Transposase
C4J93_RS11855	COG0318	PFAM AMP-dependent synthetase and ligase
C4J93_RS11885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J93_RS11885	COG0475	glutathione-regulated potassium exporter activity
C4J93_RS11890	COG1396	sequence-specific DNA binding
C4J93_RS11965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J93_RS11975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS11990	COG1177	transmembrane transport
C4J93_RS11995	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J93_RS12005	COG1414	Transcriptional regulator
C4J93_RS12015	COG0534	Mate efflux family protein
C4J93_RS12090	COG1741	Belongs to the pirin family
C4J93_RS12110	COG1917	Cupin 2, conserved barrel domain protein
C4J93_RS12110	COG4977	sequence-specific DNA binding
C4J93_RS12135	COG1335	isochorismatase
C4J93_RS12140	COG0583	DNA-binding transcription factor activity
C4J93_RS12150	COG5002	protein histidine kinase activity
C4J93_RS12150	COG5001	Diguanylate cyclase
C4J93_RS12150	COG3447	MASE1 domain protein
C4J93_RS12160	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C4J93_RS12180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J93_RS12185	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS12190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J93_RS12195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS12200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J93_RS12210	COG0583	DNA-binding transcription factor activity
C4J93_RS12230	COG5383	Protein conserved in bacteria
C4J93_RS12250	COG0616	signal peptide processing
C4J93_RS12260	COG2376	Dihydroxyacetone kinase
C4J93_RS12265	COG1063	alcohol dehydrogenase
C4J93_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS12275	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS12280	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS12285	COG1129	ABC transporter
C4J93_RS12290	COG0698	ribose 5-phosphate isomerase
C4J93_RS12305	COG1253	flavin adenine dinucleotide binding
C4J93_RS12330	COG0765	amino acid transport
C4J93_RS12335	COG0765	amino acid transport
C4J93_RS12360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J93_RS12365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J93_RS12375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J93_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS12385	COG2610	gluconate transmembrane transporter activity
C4J93_RS12390	COG3829	transcription factor binding
C4J93_RS12390	COG3290	protein histidine kinase activity
C4J93_RS12395	COG4172	Belongs to the ABC transporter superfamily
C4J93_RS12400	COG4239	(ABC) transporter, permease
C4J93_RS12405	COG4174	ABC transporter (Permease)
C4J93_RS12410	COG4166	transmembrane transport
C4J93_RS12415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J93_RS12470	COG2204	response regulator
C4J93_RS12505	COG0631	protein serine/threonine phosphatase activity
C4J93_RS12510	COG0515	serine threonine protein kinase
C4J93_RS12525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4J93_RS12560	COG3239	Fatty acid desaturase
C4J93_RS12595	COG0183	Belongs to the thiolase family
C4J93_RS12600	COG0318	PFAM AMP-dependent synthetase and ligase
C4J93_RS12605	COG0673	inositol 2-dehydrogenase activity
C4J93_RS12630	COG2706	6-phosphogluconolactonase activity
C4J93_RS12650	COG0420	3'-5' exonuclease activity
C4J93_RS12685	COG0714	Associated with various cellular activities
C4J93_RS12700	COG2186	Transcriptional regulator
C4J93_RS12715	COG0519	Catalyzes the synthesis of GMP from XMP
C4J93_RS12725	COG0625	glutathione transferase activity
C4J93_RS12760	COG2205	protein histidine kinase activity
C4J93_RS12765	COG0745	RESPONSE REGULATOR receiver
C4J93_RS12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J93_RS12795	COG3718	enzyme involved in inositol metabolism
C4J93_RS12810	COG0673	inositol 2-dehydrogenase activity
C4J93_RS12815	COG0673	inositol 2-dehydrogenase activity
C4J93_RS12825	COG1129	ABC transporter
C4J93_RS12830	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS12880	COG0673	inositol 2-dehydrogenase activity
C4J93_RS12900	COG4172	Belongs to the ABC transporter superfamily
C4J93_RS12905	COG4239	(ABC) transporter, permease
C4J93_RS12910	COG4174	ABC transporter (Permease)
C4J93_RS12915	COG4166	transmembrane transport
C4J93_RS12920	COG4166	transmembrane transport
C4J93_RS12930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J93_RS12940	COG0328	RNA-DNA hybrid ribonuclease activity
C4J93_RS12945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J93_RS12950	COG0840	transmembrane signaling receptor activity
C4J93_RS12955	COG1968	undecaprenyl-diphosphatase activity
C4J93_RS12975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J93_RS12990	COG0488	(ABC) transporter
C4J93_RS13020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4J93_RS13030	COG2133	pyrroloquinoline quinone binding
C4J93_RS13045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J93_RS13050	COG2822	iron ion transport
C4J93_RS13060	COG2822	iron ion transport
C4J93_RS13065	COG0672	)-iron permease
C4J93_RS13070	COG2207	Transcriptional regulator
C4J93_RS13105	COG2204	response regulator
C4J93_RS13110	COG2205	protein histidine kinase activity
C4J93_RS13110	COG0784	Response regulator, receiver
C4J93_RS13155	COG1538	Outer membrane efflux protein
C4J93_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS13235	COG0583	DNA-binding transcription factor activity
C4J93_RS13240	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS13275	COG1335	isochorismatase
C4J93_RS13280	COG0640	Transcriptional regulator
C4J93_RS13295	COG1132	(ABC) transporter
C4J93_RS13320	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS13330	COG0583	DNA-binding transcription factor activity
C4J93_RS13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J93_RS13385	COG0747	negative chemotaxis
C4J93_RS13400	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS13415	COG0604	alcohol dehydrogenase
C4J93_RS13415	COG3321	synthase
C4J93_RS13440	COG0210	DNA helicase
C4J93_RS13485	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J93_RS13500	COG0513	Belongs to the DEAD box helicase family
C4J93_RS13510	COG2308	Evidence 4 Homologs of previously reported genes of
C4J93_RS13540	COG0784	Response regulator, receiver
C4J93_RS13545	COG2202	Pas domain
C4J93_RS13545	COG2205	protein histidine kinase activity
C4J93_RS13560	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS13565	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS13570	COG1609	Transcriptional regulator
C4J93_RS13575	COG1070	Carbohydrate kinase
C4J93_RS13580	COG1522	sequence-specific DNA binding
C4J93_RS13590	COG0826	peptidase U32
C4J93_RS13600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J93_RS13610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J93_RS13630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J93_RS13650	COG0596	Alpha beta hydrolase
C4J93_RS13655	COG0596	Alpha beta hydrolase
C4J93_RS13670	COG0640	Transcriptional regulator
C4J93_RS13680	COG0583	DNA-binding transcription factor activity
C4J93_RS13685	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS13690	COG1942	4-Oxalocrotonate Tautomerase
C4J93_RS13740	COG2202	Pas domain
C4J93_RS13740	COG3920	Histidine kinase
C4J93_RS13770	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J93_RS13795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4J93_RS13800	COG1349	DNA-binding transcription factor activity
C4J93_RS13810	COG0738	Major facilitator superfamily
C4J93_RS13825	COG2814	Major facilitator Superfamily
C4J93_RS13830	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J93_RS13840	COG0463	Glycosyl transferase, family 2
C4J93_RS13845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J93_RS13845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J93_RS13850	COG0726	polysaccharide deacetylase
C4J93_RS13855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J93_RS13860	COG2076	Multidrug Resistance protein
C4J93_RS13865	COG2076	Multidrug Resistance protein
C4J93_RS13890	COG1024	Enoyl-CoA hydratase
C4J93_RS13895	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS13900	COG1024	Enoyl-CoA hydratase
C4J93_RS13905	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS13920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J93_RS13930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J93_RS13945	COG2205	protein histidine kinase activity
C4J93_RS13945	COG0784	Response regulator, receiver
C4J93_RS13945	COG5002	protein histidine kinase activity
C4J93_RS13955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J93_RS13960	COG0784	Response regulator, receiver
C4J93_RS13960	COG2198	Histidine kinase
C4J93_RS13960	COG2205	protein histidine kinase activity
C4J93_RS13985	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4J93_RS13990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4J93_RS14000	COG1794	racemase activity, acting on amino acids and derivatives
C4J93_RS14005	COG1247	-acetyltransferase
C4J93_RS14015	COG1929	Belongs to the glycerate kinase type-1 family
C4J93_RS14020	COG3835	regulator
C4J93_RS14025	COG2271	Major facilitator Superfamily
C4J93_RS14035	COG0583	DNA-binding transcription factor activity
C4J93_RS14040	COG0667	Aldo Keto reductase
C4J93_RS14055	COG2200	EAL domain
C4J93_RS14120	COG3258	Cytochrome c
C4J93_RS14125	COG2863	cytochrome
C4J93_RS14160	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4J93_RS14170	COG0488	(ABC) transporter
C4J93_RS14190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4J93_RS14275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J93_RS14315	COG0531	amino acid
C4J93_RS14320	COG3938	Belongs to the proline racemase family
C4J93_RS14340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS14345	COG2197	response regulator
C4J93_RS14370	COG2814	Major facilitator Superfamily
C4J93_RS14400	COG3663	DNA glycosylase
C4J93_RS14410	COG1566	PFAM secretion protein HlyD family protein
C4J93_RS14415	COG2814	Major facilitator Superfamily
C4J93_RS14425	COG0656	L-ascorbic acid biosynthetic process
C4J93_RS14450	COG2366	antibiotic biosynthetic process
C4J93_RS14465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J93_RS14470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS14475	COG1116	anion transmembrane transporter activity
C4J93_RS14475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS14495	COG0583	DNA-binding transcription factor activity
C4J93_RS14500	COG0667	Aldo Keto reductase
C4J93_RS14505	COG0840	transmembrane signaling receptor activity
C4J93_RS14515	COG0596	Alpha beta hydrolase
C4J93_RS14520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J93_RS14525	COG0297	glycogen (starch) synthase activity
C4J93_RS14530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J93_RS14535	COG1640	4-alpha-glucanotransferase
C4J93_RS14585	COG0840	transmembrane signaling receptor activity
C4J93_RS14645	COG2814	Major facilitator Superfamily
C4J93_RS14660	COG0626	cystathionine gamma-synthase activity
C4J93_RS14670	COG1944	ATP diphosphatase activity
C4J93_RS14675	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J93_RS14675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J93_RS14720	COG2271	Major facilitator Superfamily
C4J93_RS14725	COG0519	Catalyzes the synthesis of GMP from XMP
C4J93_RS14740	COG2207	Transcriptional regulator
C4J93_RS14755	COG2207	Transcriptional regulator
C4J93_RS14760	COG2223	nitrite transmembrane transporter activity
C4J93_RS14770	COG0154	amidase activity
C4J93_RS14780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J93_RS14785	COG0697	spore germination
C4J93_RS14810	COG2205	protein histidine kinase activity
C4J93_RS14815	COG0745	RESPONSE REGULATOR receiver
C4J93_RS14830	COG0589	response to stress
C4J93_RS14850	COG0814	amino acid
C4J93_RS14855	COG1335	isochorismatase
C4J93_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS14885	COG0308	aminopeptidase N
C4J93_RS14895	COG3139	Protein of unknown function (DUF1315)
C4J93_RS14905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J93_RS14910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4J93_RS14960	COG0316	Belongs to the HesB IscA family
C4J93_RS14960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4J93_RS14985	COG0028	Belongs to the TPP enzyme family
C4J93_RS14990	COG0431	NADPH-dependent FMN reductase
C4J93_RS15010	COG0456	acetyltransferase
C4J93_RS15035	COG0708	Exodeoxyribonuclease III
C4J93_RS15045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4J93_RS15065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J93_RS15070	COG1116	anion transmembrane transporter activity
C4J93_RS15075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J93_RS15100	COG2816	NAD+ diphosphatase activity
C4J93_RS15105	COG1024	Enoyl-CoA hydratase
C4J93_RS15110	COG3318	Belongs to the UPF0149 family
C4J93_RS15110	COG3012	SEC-C Motif Domain Protein
C4J93_RS15115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J93_RS15125	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J93_RS15145	COG0784	Response regulator, receiver
C4J93_RS15145	COG4191	Histidine kinase
C4J93_RS15155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J93_RS15160	COG0366	Alpha amylase catalytic
C4J93_RS15170	COG1285	pathogenesis
C4J93_RS15180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J93_RS15190	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS15195	COG2066	Belongs to the glutaminase family
C4J93_RS15210	COG4191	Histidine kinase
C4J93_RS15210	COG0784	Response regulator, receiver
C4J93_RS15215	COG0587	DNA-directed DNA polymerase activity
C4J93_RS15235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4J93_RS15240	COG0494	nUDIX hydrolase
C4J93_RS15250	COG1304	FMN binding
C4J93_RS15275	COG0693	protein deglycase activity
C4J93_RS15290	COG1999	signal sequence binding
C4J93_RS15335	COG2072	flavoprotein involved in K transport
C4J93_RS15355	COG0583	DNA-binding transcription factor activity
C4J93_RS15360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J93_RS15365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4J93_RS15370	COG0596	Alpha beta hydrolase
C4J93_RS15380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J93_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS15405	COG0583	DNA-binding transcription factor activity
C4J93_RS15415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J93_RS15435	COG2814	Major facilitator Superfamily
C4J93_RS15440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS15445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J93_RS15500	COG3706	GGDEF domain
C4J93_RS15505	COG1280	lysine exporter protein (LysE YggA)
C4J93_RS15520	COG2186	Transcriptional regulator
C4J93_RS15525	COG1522	sequence-specific DNA binding
C4J93_RS15535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J93_RS15540	COG2814	Major facilitator Superfamily
C4J93_RS15570	COG3121	Chaperone
C4J93_RS15580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS15580	COG2205	protein histidine kinase activity
C4J93_RS15585	COG2197	response regulator
C4J93_RS15590	COG3706	GGDEF domain
C4J93_RS15590	COG5001	Diguanylate cyclase
C4J93_RS15590	COG4251	negative regulation of phosphorylation
C4J93_RS15590	COG2203	Gaf domain
C4J93_RS15600	COG2207	Transcriptional regulator
C4J93_RS15610	COG1063	alcohol dehydrogenase
C4J93_RS15615	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4J93_RS15645	COG0395	ABC-type sugar transport system, permease component
C4J93_RS15655	COG3842	ATPase activity
C4J93_RS15660	COG3842	ATPase activity
C4J93_RS15665	COG3284	Transcriptional regulator
C4J93_RS15700	COG2192	nodulation
C4J93_RS15715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C4J93_RS15780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4J93_RS15785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J93_RS15790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4J93_RS15795	COG2835	tetraacyldisaccharide 4'-kinase activity
C4J93_RS15800	COG1663	tetraacyldisaccharide 4'-kinase activity
C4J93_RS15805	COG0848	biopolymer transport protein
C4J93_RS15810	COG0811	peptide transport
C4J93_RS15815	COG0658	competence protein
C4J93_RS15815	COG2333	competence protein COMEC
C4J93_RS15840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J93_RS15860	COG1393	Belongs to the ArsC family
C4J93_RS15875	COG2818	Glycosylase
C4J93_RS15880	COG0037	tRNA processing
C4J93_RS15895	COG3091	SprT-like family
C4J93_RS15900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J93_RS15920	COG2920	part of a sulfur-relay system
C4J93_RS15930	COG0435	Glutathione S-transferase
C4J93_RS15935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J93_RS15935	COG1648	precorrin-2 dehydrogenase activity
C4J93_RS15940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4J93_RS15945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J93_RS15950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4J93_RS15955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4J93_RS15960	COG1674	ftsk spoiiie
C4J93_RS15965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4J93_RS15970	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4J93_RS15975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4J93_RS15980	COG0542	response to heat
C4J93_RS15985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4J93_RS15990	COG1278	Cold shock
C4J93_RS16005	COG0583	DNA-binding transcription factor activity
C4J93_RS16020	COG0482	sulfurtransferase activity
C4J93_RS16025	COG2915	High frequency lysogenization protein hflD homolog
C4J93_RS16035	COG2850	peptidyl-arginine hydroxylation
C4J93_RS16040	COG2153	protein acetylation
C4J93_RS16050	COG2224	Isocitrate lyase
C4J93_RS16055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J93_RS16060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J93_RS16065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J93_RS16065	COG0649	NAD binding
C4J93_RS16080	COG1034	ATP synthesis coupled electron transport
C4J93_RS16085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J93_RS16090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J93_RS16100	COG0713	ATP synthesis coupled electron transport
C4J93_RS16115	COG1007	ATP synthesis coupled electron transport
C4J93_RS16120	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4J93_RS16125	COG2944	sequence-specific DNA binding
C4J93_RS16155	COG2814	Major facilitator Superfamily
C4J93_RS16170	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS16185	COG1136	(ABC) transporter
C4J93_RS16185	COG0577	efflux transmembrane transporter activity
C4J93_RS16190	COG1136	(ABC) transporter
C4J93_RS16190	COG0577	efflux transmembrane transporter activity
C4J93_RS16270	COG2111	Na H antiporter
C4J93_RS16270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J93_RS16275	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J93_RS16280	COG0651	ATP synthesis coupled electron transport
C4J93_RS16290	COG2212	antiporter activity
C4J93_RS16295	COG1320	monovalent cation:proton antiporter activity
C4J93_RS16305	COG0215	cysteine-tRNA ligase activity
C4J93_RS16310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J93_RS16320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J93_RS16325	COG2814	Major facilitator Superfamily
C4J93_RS16330	COG1566	PFAM secretion protein HlyD family protein
C4J93_RS16340	COG1846	Transcriptional regulator
C4J93_RS16345	COG2911	Protein conserved in bacteria
C4J93_RS16350	COG0729	surface antigen
C4J93_RS16360	COG0708	Exodeoxyribonuclease III
C4J93_RS16365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4J93_RS16370	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS16380	COG0789	Transcriptional regulator
C4J93_RS16395	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS16400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J93_RS16425	COG2866	Carboxypeptidase
C4J93_RS16430	COG3038	cytochrome b561
C4J93_RS16450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J93_RS16460	COG0217	transcriptional regulatory protein
C4J93_RS16465	COG0583	DNA-binding transcription factor activity
C4J93_RS16470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J93_RS16475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J93_RS16480	COG3038	cytochrome b561
C4J93_RS16490	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS16490	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J93_RS16510	COG1846	Transcriptional regulator
C4J93_RS16515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J93_RS16525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J93_RS16530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J93_RS16535	COG0776	regulation of translation
C4J93_RS16540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J93_RS16545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4J93_RS16550	COG0740	serine-type endopeptidase activity
C4J93_RS16555	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4J93_RS16580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4J93_RS16615	COG1686	Belongs to the peptidase S11 family
C4J93_RS16655	COG1953	Uracil, thiamine, allantoin
C4J93_RS16665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J93_RS16665	COG0493	'glutamate synthase
C4J93_RS16675	COG1309	transcriptional regulator
C4J93_RS16695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J93_RS16705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4J93_RS16745	COG0640	Transcriptional regulator
C4J93_RS16755	COG1522	sequence-specific DNA binding
C4J93_RS16760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J93_RS16765	COG0022	dehydrogenase e1 component
C4J93_RS16775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J93_RS16780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J93_RS16820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J93_RS16825	COG1136	(ABC) transporter
C4J93_RS16825	COG0577	efflux transmembrane transporter activity
C4J93_RS16840	COG2186	Transcriptional regulator
C4J93_RS16885	COG1609	Transcriptional regulator
C4J93_RS16890	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS16895	COG1070	Carbohydrate kinase
C4J93_RS16900	COG1063	alcohol dehydrogenase
C4J93_RS16905	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS16915	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS16935	COG1136	(ABC) transporter
C4J93_RS16945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J93_RS16950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J93_RS16995	COG0583	DNA-binding transcription factor activity
C4J93_RS17000	COG0583	DNA-binding transcription factor activity
C4J93_RS17005	COG0625	glutathione transferase activity
C4J93_RS17020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J93_RS17035	COG0667	Aldo Keto reductase
C4J93_RS17065	COG1231	oxidoreductase activity
C4J93_RS17070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS17075	COG1126	abc transporter atp-binding protein
C4J93_RS17090	COG1450	Type ii and iii secretion system protein
C4J93_RS17105	COG3166	PFAM Fimbrial assembly family protein
C4J93_RS17110	COG3156	type II secretion system protein K
C4J93_RS17125	COG2165	general secretion pathway protein
C4J93_RS17130	COG2165	general secretion pathway protein
C4J93_RS17135	COG1459	type II secretion system
C4J93_RS17140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J93_RS17175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J93_RS17210	COG0776	regulation of translation
C4J93_RS17215	COG0072	phenylalanine-tRNA ligase activity
C4J93_RS17220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J93_RS17225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4J93_RS17230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4J93_RS17235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4J93_RS17240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J93_RS17250	COG1278	Cold shock
C4J93_RS17275	COG1869	D-ribose catabolic process
C4J93_RS17280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J93_RS17285	COG1609	Transcriptional regulator
C4J93_RS17290	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS17295	COG1129	ABC transporter
C4J93_RS17300	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS17325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J93_RS17335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J93_RS17350	COG0642	Histidine kinase
C4J93_RS17445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS17480	COG1286	toxin biosynthetic process
C4J93_RS17485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J93_RS17490	COG0285	dihydrofolate synthase activity
C4J93_RS17495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4J93_RS17500	COG0135	phosphoribosylanthranilate isomerase activity
C4J93_RS17525	COG0473	3-isopropylmalate dehydrogenase activity
C4J93_RS17530	COG2226	methyltransferase
C4J93_RS17535	COG0066	3-isopropylmalate dehydratase activity
C4J93_RS17540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J93_RS17565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J93_RS17575	COG0596	Alpha beta hydrolase
C4J93_RS17605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J93_RS17610	COG0556	nucleotide-excision repair
C4J93_RS17625	COG0583	DNA-binding transcription factor activity
C4J93_RS17630	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS17650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J93_RS17655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J93_RS17660	COG1120	ATPase activity
C4J93_RS17675	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4J93_RS17715	COG0251	oxidation-reduction process
C4J93_RS17720	COG2267	carboxylic ester hydrolase activity
C4J93_RS17760	COG3011	Protein conserved in bacteria
C4J93_RS17785	COG0477	Major facilitator Superfamily
C4J93_RS17820	COG0840	transmembrane signaling receptor activity
C4J93_RS17825	COG2384	SAM-dependent methyltransferase
C4J93_RS17830	COG2186	Transcriptional regulator
C4J93_RS17870	COG2391	methyltransferase activity
C4J93_RS17880	COG0583	DNA-binding transcription factor activity
C4J93_RS17885	COG1304	FMN binding
C4J93_RS17900	COG5001	Diguanylate cyclase
C4J93_RS17900	COG5002	protein histidine kinase activity
C4J93_RS17915	COG1054	Belongs to the UPF0176 family
C4J93_RS17945	COG0271	Belongs to the BolA IbaG family
C4J93_RS17955	COG0114	fumarate hydratase activity
C4J93_RS17960	COG0697	spore germination
C4J93_RS17975	COG3539	Fimbrial protein
C4J93_RS17980	COG3539	Fimbrial protein
C4J93_RS17995	COG3121	Chaperone
C4J93_RS18020	COG0183	Belongs to the thiolase family
C4J93_RS18025	COG2326	polyphosphate kinase activity
C4J93_RS18030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS18030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4J93_RS18035	COG0367	asparagine synthase
C4J93_RS18040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J93_RS18040	COG0189	ligase activity
C4J93_RS18045	COG1363	Peptidase, m42
C4J93_RS18050	COG3089	Belongs to the UPF0270 family
C4J93_RS18055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J93_RS18070	COG1368	sulfuric ester hydrolase activity
C4J93_RS18095	COG2197	response regulator
C4J93_RS18100	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4J93_RS18110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4J93_RS18115	COG1073	alpha beta
C4J93_RS18140	COG2840	Smr protein MutS2
C4J93_RS18145	COG0302	gtp cyclohydrolase
C4J93_RS18165	COG2851	Citrate transporter
C4J93_RS18170	COG0583	DNA-binding transcription factor activity
C4J93_RS18180	COG0625	glutathione transferase activity
C4J93_RS18185	COG2252	PERMEase
C4J93_RS18215	COG4266	Belongs to the allantoicase family
C4J93_RS18220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4J93_RS18230	COG2233	PERMEase
C4J93_RS18245	COG1560	Kdo2-lipid A biosynthetic process
C4J93_RS18250	COG0850	regulation of cytokinetic process
C4J93_RS18255	COG2894	cell division
C4J93_RS18260	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4J93_RS18265	COG0564	pseudouridine synthase activity
C4J93_RS18270	COG1362	aminopeptidase activity
C4J93_RS18275	COG0668	transmembrane transport
C4J93_RS18310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J93_RS18340	COG3385	transposase activity
C4J93_RS18355	COG1309	transcriptional regulator
C4J93_RS18365	COG3123	guanosine phosphorylase activity
C4J93_RS18385	COG3851	Histidine kinase
C4J93_RS18390	COG2197	response regulator
C4J93_RS18395	COG1597	lipid kinase activity
C4J93_RS18405	COG0835	chemotaxis
C4J93_RS18415	COG1192	Involved in chromosome partitioning
C4J93_RS18420	COG1360	Flagellar Motor Protein
C4J93_RS18430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4J93_RS18435	COG2201	protein-glutamate methylesterase activity
C4J93_RS18440	COG0643	Histidine kinase
C4J93_RS18440	COG0784	Response regulator, receiver
C4J93_RS18440	COG2198	Histidine kinase
C4J93_RS18445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4J93_RS18570	COG1677	Flagellar hook-basal body complex protein FliE
C4J93_RS18600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4J93_RS18635	COG1706	bacterial-type flagellum-dependent cell motility
C4J93_RS18640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4J93_RS18650	COG4787	bacterial-type flagellum-dependent cell motility
C4J93_RS18655	COG3415	Transposase
C4J93_RS18655	COG2801	Transposase and inactivated derivatives
C4J93_RS18670	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4J93_RS18685	COG2207	Transcriptional regulator
C4J93_RS18700	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4J93_RS18705	COG1846	Transcriptional regulator
C4J93_RS18710	COG0514	ATP-dependent DNA helicase (RecQ)
C4J93_RS18720	COG2832	Protein of unknown function (DUF454)
C4J93_RS18725	COG2198	Histidine kinase
C4J93_RS18725	COG2205	protein histidine kinase activity
C4J93_RS18725	COG0784	Response regulator, receiver
C4J93_RS18775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4J93_RS18780	COG0406	alpha-ribazole phosphatase activity
C4J93_RS18785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J93_RS18795	COG1492	cobalamin metabolic process
C4J93_RS18805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4J93_RS18810	COG0778	Nitroreductase
C4J93_RS18815	COG1797	cobyrinic acid a,c-diamide synthase activity
C4J93_RS18830	COG0791	NLP P60 protein
C4J93_RS18835	COG0791	NLP P60 protein
C4J93_RS18840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J93_RS18845	COG0628	permease
C4J93_RS18855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4J93_RS18860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4J93_RS18880	COG4264	IucA IucC family
C4J93_RS18885	COG2814	Major facilitator Superfamily
C4J93_RS18895	COG3122	Protein conserved in bacteria
C4J93_RS18900	COG3956	TIGRFAM MazG family protein
C4J93_RS18905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J93_RS18910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J93_RS18945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J93_RS18955	COG0583	DNA-binding transcription factor activity
C4J93_RS18965	COG1953	Uracil, thiamine, allantoin
C4J93_RS18975	COG2996	Protein conserved in bacteria
C4J93_RS19005	COG0513	Belongs to the DEAD box helicase family
C4J93_RS19010	COG2226	methyltransferase
C4J93_RS19040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J93_RS19060	COG1132	(ABC) transporter
C4J93_RS19075	COG2188	Transcriptional regulator
C4J93_RS19085	COG1595	DNA-templated transcription, initiation
C4J93_RS19095	COG1643	Atp-dependent helicase
C4J93_RS19110	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4J93_RS19120	COG0840	transmembrane signaling receptor activity
C4J93_RS19135	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J93_RS19150	COG2010	Cytochrome c
C4J93_RS19155	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J93_RS19170	COG2010	Cytochrome c
C4J93_RS19185	COG0348	domain, Protein
C4J93_RS19195	COG2217	Heavy metal translocating P-type atpase
C4J93_RS19220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J93_RS19225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J93_RS19230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4J93_RS19235	COG2130	NADP-dependent
C4J93_RS19240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4J93_RS19245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4J93_RS19275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J93_RS19280	COG3115	cell septum assembly
C4J93_RS19300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J93_RS19310	COG0402	S-adenosylhomocysteine deaminase activity
C4J93_RS19315	COG1802	Transcriptional regulator
C4J93_RS19320	COG3135	benzoate transporter
C4J93_RS19325	COG3171	Protein conserved in bacteria
C4J93_RS19340	COG0116	Belongs to the methyltransferase superfamily
C4J93_RS19340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J93_RS19345	COG3130	regulation of translation
C4J93_RS19350	COG0167	dihydroorotate dehydrogenase activity
C4J93_RS19365	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J93_RS19375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS19375	COG1116	anion transmembrane transporter activity
C4J93_RS19380	COG3707	response regulator
C4J93_RS19385	COG2223	nitrite transmembrane transporter activity
C4J93_RS19395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J93_RS19400	COG2146	nitrite reductase [NAD(P)H] activity
C4J93_RS19405	COG0243	molybdopterin cofactor binding
C4J93_RS19410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J93_RS19415	COG2885	chlorophyll binding
C4J93_RS19415	COG3047	cAMP biosynthetic process
C4J93_RS19440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J93_RS19455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4J93_RS19465	COG2801	Transposase and inactivated derivatives
C4J93_RS19465	COG3415	Transposase
C4J93_RS19470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J93_RS19485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J93_RS19490	COG1045	serine acetyltransferase
C4J93_RS19495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J93_RS19515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4J93_RS19520	COG0372	Belongs to the citrate synthase family
C4J93_RS19530	COG1802	Transcriptional regulator
C4J93_RS19535	COG0189	ligase activity
C4J93_RS19535	COG4067	protein conserved in archaea
C4J93_RS19545	COG0189	ligase activity
C4J93_RS19550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J93_RS19560	COG0560	Phosphoserine phosphatase
C4J93_RS19570	COG1953	Uracil, thiamine, allantoin
C4J93_RS19580	COG0583	DNA-binding transcription factor activity
C4J93_RS19585	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS19590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J93_RS19620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J93_RS19620	COG2169	Transcriptional regulator
C4J93_RS19630	COG5001	Diguanylate cyclase
C4J93_RS19630	COG4251	negative regulation of phosphorylation
C4J93_RS19630	COG3706	GGDEF domain
C4J93_RS19630	COG2203	Gaf domain
C4J93_RS19650	COG0598	Magnesium transport protein CorA
C4J93_RS19655	COG0519	Catalyzes the synthesis of GMP from XMP
C4J93_RS19655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J93_RS19660	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J93_RS19660	COG1024	Enoyl-CoA hydratase
C4J93_RS19665	COG0183	Belongs to the thiolase family
C4J93_RS19675	COG1305	Transglutaminase-like
C4J93_RS19685	COG2308	Evidence 4 Homologs of previously reported genes of
C4J93_RS19715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J93_RS19720	COG2885	chlorophyll binding
C4J93_RS19720	COG3047	cAMP biosynthetic process
C4J93_RS19750	COG2207	Transcriptional regulator
C4J93_RS19755	COG1064	alcohol dehydrogenase
C4J93_RS19760	COG1414	Transcriptional regulator
C4J93_RS19765	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J93_RS19770	COG1129	ABC transporter
C4J93_RS19775	COG1879	ABC-type sugar transport system periplasmic component
C4J93_RS19780	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS19805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J93_RS19815	COG1397	ADP-ribosylglycohydrolase
C4J93_RS19820	COG2188	Transcriptional regulator
C4J93_RS19835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J93_RS19845	COG0084	hydrolase, TatD family'
C4J93_RS19855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J93_RS19860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4J93_RS19870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J93_RS19875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J93_RS19890	COG0416	fatty acid biosynthetic process
C4J93_RS19895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4J93_RS19900	COG1399	metal-binding, possibly nucleic acid-binding protein
C4J93_RS19905	COG0424	maF-like protein
C4J93_RS19910	COG0616	signal peptide processing
C4J93_RS19910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J93_RS19915	COG0546	phosphoglycolate phosphatase activity
C4J93_RS19930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J93_RS19935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4J93_RS19935	COG3608	succinylglutamate desuccinylase aspartoacylase
C4J93_RS19950	COG1301	dicarboxylic acid transport
C4J93_RS19955	COG4977	sequence-specific DNA binding
C4J93_RS19955	COG1917	Cupin 2, conserved barrel domain protein
C4J93_RS19980	COG2205	protein histidine kinase activity
C4J93_RS19985	COG0745	RESPONSE REGULATOR receiver
C4J93_RS20005	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4J93_RS20015	COG1815	bacterial-type flagellum-dependent cell motility
C4J93_RS20020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J93_RS20025	COG0835	chemotaxis
C4J93_RS20025	COG0784	Response regulator, receiver
C4J93_RS20045	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4J93_RS20050	COG0477	Major facilitator Superfamily
C4J93_RS20105	COG2239	Acts as a magnesium transporter
C4J93_RS20130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J93_RS20135	COG0527	aspartate kinase activity
C4J93_RS20140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J93_RS20145	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4J93_RS20150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J93_RS20155	COG2988	succinylglutamate desuccinylase activity
C4J93_RS20165	COG3724	N-succinylarginine dihydrolase activity
C4J93_RS20170	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS20185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J93_RS20225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS20235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J93_RS20245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J93_RS20280	COG0154	amidase activity
C4J93_RS20315	COG0504	CTP synthase activity
C4J93_RS20320	COG2329	Antibiotic biosynthesis monooxygenase
C4J93_RS20350	COG0306	phosphate transporter
C4J93_RS20355	COG0583	DNA-binding transcription factor activity
C4J93_RS20360	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS20370	COG0583	DNA-binding transcription factor activity
C4J93_RS20375	COG4941	Belongs to the sigma-70 factor family
C4J93_RS20380	COG3795	YCII-related domain
C4J93_RS20400	COG3550	peptidyl-serine autophosphorylation
C4J93_RS20410	COG0436	Aminotransferase
C4J93_RS20425	COG3265	gluconokinase activity
C4J93_RS20430	COG1609	Transcriptional regulator
C4J93_RS20445	COG2271	Major facilitator Superfamily
C4J93_RS20455	COG0583	DNA-binding transcription factor activity
C4J93_RS20465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS20475	COG0242	peptide deformylase activity
C4J93_RS20480	COG1295	ribonuclease BN
C4J93_RS20495	COG0318	PFAM AMP-dependent synthetase and ligase
C4J93_RS20500	COG0318	PFAM AMP-dependent synthetase and ligase
C4J93_RS20510	COG2030	dehydratase
C4J93_RS20520	COG3530	Putative quorum-sensing-regulated virulence factor
C4J93_RS20525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J93_RS20530	COG0800	Aldolase
C4J93_RS20545	COG1737	Transcriptional regulator
C4J93_RS20550	COG0676	glucose-6-phosphate 1-epimerase activity
C4J93_RS20560	COG3842	ATPase activity
C4J93_RS20565	COG0395	ABC-type sugar transport system, permease component
C4J93_RS20570	COG1175	transmembrane transport
C4J93_RS20575	COG1653	transport
C4J93_RS20590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J93_RS20595	COG0583	DNA-binding transcription factor activity
C4J93_RS20610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4J93_RS20630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4J93_RS20660	COG1113	amino acid transport
C4J93_RS20680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4J93_RS20690	COG0009	L-threonylcarbamoyladenylate synthase
C4J93_RS20695	COG0613	PHP domain protein
C4J93_RS20700	COG2917	probably involved in intracellular septation
C4J93_RS20705	COG2350	Protein conserved in bacteria
C4J93_RS20715	COG0745	RESPONSE REGULATOR receiver
C4J93_RS20725	COG0642	Histidine kinase
C4J93_RS20770	COG0509	glycine decarboxylation via glycine cleavage system
C4J93_RS20775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J93_RS20775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J93_RS20780	COG1760	l-serine dehydratase
C4J93_RS20785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J93_RS20790	COG1278	Cold shock
C4J93_RS20800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4J93_RS20840	COG1538	Outer membrane efflux protein
C4J93_RS20850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J93_RS20860	COG0602	queuosine metabolic process
C4J93_RS20865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4J93_RS20870	COG2885	chlorophyll binding
C4J93_RS20875	COG0823	Involved in the tonB-independent uptake of proteins
C4J93_RS20895	COG0824	Thioesterase
C4J93_RS20905	COG2255	four-way junction helicase activity
C4J93_RS20910	COG0632	four-way junction helicase activity
C4J93_RS20915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4J93_RS20925	COG0217	transcriptional regulatory protein
C4J93_RS20930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4J93_RS20945	COG0783	Belongs to the Dps family
C4J93_RS20955	COG2900	Belongs to the SlyX family
C4J93_RS20970	COG0668	transmembrane transport
C4J93_RS20975	COG1666	GTP binding
C4J93_RS20985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS20985	COG4191	Histidine kinase
C4J93_RS20990	COG2096	Adenosyltransferase
C4J93_RS21000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4J93_RS21005	COG0653	protein targeting
C4J93_RS21015	COG0433	COG0433 Predicted ATPase
C4J93_RS21025	COG0438	transferase activity, transferring glycosyl groups
C4J93_RS21025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J93_RS21050	COG2925	Exonuclease
C4J93_RS21075	COG0714	Associated with various cellular activities
C4J93_RS21095	COG0469	pyruvate kinase activity
C4J93_RS21100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J93_RS21110	COG4191	Histidine kinase
C4J93_RS21120	COG0477	Major facilitator Superfamily
C4J93_RS21140	COG2207	Transcriptional regulator
C4J93_RS21170	COG1595	DNA-templated transcription, initiation
C4J93_RS21180	COG4771	TonB-dependent receptor
C4J93_RS21190	COG2832	Protein of unknown function (DUF454)
C4J93_RS21195	COG0840	transmembrane signaling receptor activity
C4J93_RS21200	COG1522	sequence-specific DNA binding
C4J93_RS21210	COG2423	ornithine cyclodeaminase activity
C4J93_RS21215	COG1113	amino acid transport
C4J93_RS21245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J93_RS21255	COG3642	lipopolysaccharide core region biosynthetic process
C4J93_RS21265	COG0642	Histidine kinase
C4J93_RS21275	COG1368	sulfuric ester hydrolase activity
C4J93_RS21285	COG0459	protein refolding
C4J93_RS21290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4J93_RS21315	COG2211	Major facilitator Superfamily
C4J93_RS21320	COG0442	prolyl-tRNA aminoacylation
C4J93_RS21330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4J93_RS21395	COG4974	Belongs to the 'phage' integrase family
C4J93_RS21405	COG0335	large ribosomal subunit rRNA binding
C4J93_RS21410	COG0336	Belongs to the RNA methyltransferase TrmD family
C4J93_RS21415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4J93_RS21420	COG0228	four-way junction DNA binding
C4J93_RS21425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4J93_RS21435	COG4536	flavin adenine dinucleotide binding
C4J93_RS21440	COG0477	Major facilitator Superfamily
C4J93_RS21445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4J93_RS21465	COG0494	nUDIX hydrolase
C4J93_RS21470	COG2816	NAD+ diphosphatase activity
C4J93_RS21480	COG2188	Transcriptional regulator
C4J93_RS21485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4J93_RS21490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J93_RS21495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J93_RS21495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J93_RS21500	COG1263	PTS System
C4J93_RS21500	COG2190	(PTS) system
C4J93_RS21500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J93_RS21515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4J93_RS21520	COG0047	phosphoribosylformylglycinamidine synthase activity
C4J93_RS21520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J93_RS21525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J93_RS21580	COG5314	conjugation
C4J93_RS21605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J93_RS21625	COG0431	NADPH-dependent FMN reductase
C4J93_RS21650	COG0582	viral genome integration into host DNA
C4J93_RS21655	COG0519	Catalyzes the synthesis of GMP from XMP
C4J93_RS21655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J93_RS21675	COG1570	exodeoxyribonuclease VII activity
C4J93_RS21680	COG0739	heme binding
C4J93_RS21690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J93_RS21695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J93_RS21700	COG0436	Aminotransferase
C4J93_RS21705	COG1160	GTP binding
C4J93_RS21720	COG0124	histidyl-tRNA synthetase
C4J93_RS21725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J93_RS21730	COG1426	Protein conserved in bacteria
C4J93_RS21740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4J93_RS21745	COG0105	UTP biosynthetic process
C4J93_RS21755	COG0633	Ferredoxin
C4J93_RS21760	COG0443	Heat shock 70 kDa protein
C4J93_RS21765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J93_RS21770	COG0316	Belongs to the HesB IscA family
C4J93_RS21780	COG1104	cysteine desulfurase activity
C4J93_RS21805	COG3134	Outer membrane lipoprotein
C4J93_RS21820	COG1862	Preprotein translocase
C4J93_RS21825	COG0343	queuine tRNA-ribosyltransferase activity
C4J93_RS21830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4J93_RS21865	COG0243	molybdopterin cofactor binding
C4J93_RS21910	COG1280	lysine exporter protein (LysE YggA)
C4J93_RS21920	COG1569	PIN domain
C4J93_RS21925	COG3311	Transcriptional regulator
C4J93_RS21960	COG4251	negative regulation of phosphorylation
C4J93_RS21975	COG2853	Lipoprotein
C4J93_RS21990	COG3706	GGDEF domain
C4J93_RS22000	COG2161	toxin-antitoxin pair type II binding
C4J93_RS22015	COG1104	cysteine desulfurase activity
C4J93_RS22020	COG2814	Major facilitator Superfamily
C4J93_RS22040	COG2197	response regulator
C4J93_RS22045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J93_RS22050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4J93_RS22055	COG0109	protoheme IX farnesyltransferase activity
C4J93_RS22065	COG1845	cytochrome c oxidase, subunit III
C4J93_RS22070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J93_RS22075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J93_RS22085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J93_RS22090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J93_RS22090	COG1017	nitric oxide dioxygenase activity
C4J93_RS22095	COG3604	Transcriptional regulator
C4J93_RS22105	COG2207	Transcriptional regulator
C4J93_RS22105	COG3708	Transcriptional regulator
C4J93_RS22110	COG2197	response regulator
C4J93_RS22125	COG1028	Short-chain dehydrogenase reductase Sdr
C4J93_RS22145	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J93_RS22170	COG0302	gtp cyclohydrolase
C4J93_RS22175	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J93_RS22190	COG0492	ferredoxin-NADP+ reductase activity
C4J93_RS22200	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4J93_RS22215	COG0386	Belongs to the glutathione peroxidase family
C4J93_RS22220	COG3045	CreA protein
C4J93_RS22225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4J93_RS22230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4J93_RS22235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4J93_RS22240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4J93_RS22245	COG0142	geranyltranstransferase activity
C4J93_RS22250	COG2824	Alkylphosphonate utilization operon protein PhnA
C4J93_RS22255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J93_RS22260	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J93_RS22265	COG0840	transmembrane signaling receptor activity
C4J93_RS22275	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4J93_RS22285	COG2610	gluconate transmembrane transporter activity
C4J93_RS22295	COG0659	secondary active sulfate transmembrane transporter activity
C4J93_RS22305	COG0583	DNA-binding transcription factor activity
C4J93_RS22315	COG0583	DNA-binding transcription factor activity
C4J93_RS22320	COG1113	amino acid transport
C4J93_RS22330	COG1522	sequence-specific DNA binding
C4J93_RS22335	COG3485	protocatechuate 3,4-dioxygenase
C4J93_RS22345	COG4948	Mandelate Racemase Muconate Lactonizing
C4J93_RS22360	COG4638	Rieske (2fe-2S)
C4J93_RS22365	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4J93_RS22370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J93_RS22370	COG0543	2 iron, 2 sulfur cluster binding
C4J93_RS22375	COG1113	amino acid transport
C4J93_RS22380	COG3483	tryptophan 2,3-dioxygenase activity
C4J93_RS22385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4J93_RS22440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J93_RS22445	COG1074	ATP-dependent DNA helicase activity
C4J93_RS22450	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4J93_RS22485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4J93_RS22490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J93_RS22495	COG1183	phosphatidylcholine synthase activity
C4J93_RS22500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4J93_RS22510	COG0028	Belongs to the TPP enzyme family
C4J93_RS22515	COG3098	single-species biofilm formation
C4J93_RS22525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J93_RS22545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J93_RS22550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J93_RS22555	COG4558	Periplasmic binding protein
C4J93_RS22565	COG1489	DNA binding
C4J93_RS22570	COG0436	Aminotransferase
C4J93_RS22580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J93_RS22590	COG4191	Histidine kinase
C4J93_RS22610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J93_RS22615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4J93_RS22620	COG0166	Belongs to the GPI family
C4J93_RS22625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J93_RS22630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J93_RS22640	COG2823	Periplasmic or secreted lipoprotein
C4J93_RS22645	COG1185	polyribonucleotide nucleotidyltransferase activity
C4J93_RS22650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4J93_RS22655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4J93_RS22660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4J93_RS22665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4J93_RS22670	COG0195	Participates in both transcription termination and antitermination
C4J93_RS22675	COG0779	Required for maturation of 30S ribosomal subunits
C4J93_RS22690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J93_RS22695	COG0149	triose-phosphate isomerase activity
C4J93_RS22700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J93_RS22705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J93_RS22715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4J93_RS22730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J93_RS22735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4J93_RS22740	COG0505	Belongs to the CarA family
C4J93_RS22745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4J93_RS22750	COG0484	heat shock protein binding
C4J93_RS22755	COG0443	Heat shock 70 kDa protein
C4J93_RS22760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4J93_RS22765	COG0497	DNA recombination
C4J93_RS22770	COG0735	belongs to the Fur family
C4J93_RS22775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J93_RS22780	COG2914	Belongs to the UPF0125 (RnfH) family
C4J93_RS22790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4J93_RS22795	COG2186	Transcriptional regulator
C4J93_RS22800	COG1620	l-lactate permease
C4J93_RS22845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J93_RS22845	COG0784	Response regulator, receiver
C4J93_RS22860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J93_RS22865	COG3781	membrane
C4J93_RS22870	COG0583	DNA-binding transcription factor activity
C4J93_RS22880	COG2862	Uncharacterized protein family, UPF0114
C4J93_RS22895	COG1067	ATP-dependent peptidase activity
C4J93_RS22915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J93_RS22935	COG2814	Major facilitator Superfamily
C4J93_RS22940	COG0583	DNA-binding transcription factor activity
C4J93_RS22945	COG0488	(ABC) transporter
C4J93_RS22960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J93_RS22965	COG0523	cobalamin synthesis protein
C4J93_RS22970	COG2879	small protein
C4J93_RS22975	COG1966	Carbon starvation protein
C4J93_RS22995	COG1970	mechanosensitive ion channel activity
C4J93_RS23010	COG2813	Specifically methylates the guanine in position
C4J93_RS23020	COG1294	oxidase, subunit
C4J93_RS23025	COG1271	oxidase subunit
C4J93_RS23035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J93_RS23040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4J93_RS23045	COG2080	2 iron, 2 sulfur cluster binding
C4J93_RS23055	COG2252	PERMEase
C4J93_RS23060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J93_RS23075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J93_RS23080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J93_RS23085	COG1309	transcriptional regulator
C4J93_RS23090	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4J93_RS23090	COG1082	Xylose isomerase domain protein TIM barrel
C4J93_RS23095	COG0477	Major facilitator Superfamily
C4J93_RS23110	COG2321	neutral zinc metallopeptidase
C4J93_RS23130	COG1946	Acyl-CoA thioesterase
C4J93_RS23140	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4J93_RS23145	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J93_RS23145	COG0493	'glutamate synthase
C4J93_RS23150	COG0513	Belongs to the DEAD box helicase family
C4J93_RS23155	COG0697	spore germination
C4J93_RS23165	COG1199	ATP-dependent helicase activity
C4J93_RS23165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J93_RS23175	COG3416	Protein conserved in bacteria
C4J93_RS23190	COG3622	Belongs to the hyi family
C4J93_RS23205	COG1643	Atp-dependent helicase
C4J93_RS23220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4J93_RS23230	COG1522	sequence-specific DNA binding
C4J93_RS23245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J93_RS23250	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS23260	COG0351	phosphomethylpyrimidine kinase
C4J93_RS23265	COG0352	thiamine-phosphate diphosphorylase activity
C4J93_RS23270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J93_RS23285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J93_RS23290	COG1702	phosphate starvation-inducible protein PhoH
C4J93_RS23295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4J93_RS23300	COG4535	Mg2 and Co2 transporter CorC
C4J93_RS23305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4J93_RS23320	COG0495	leucyl-tRNA aminoacylation
C4J93_RS23330	COG1466	dna polymerase III delta subunit
C4J93_RS23340	COG2951	lytic endotransglycosylase activity
C4J93_RS23345	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4J93_RS23350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4J93_RS23355	COG0321	lipoyl(octanoyl) transferase activity
C4J93_RS23360	COG2921	Belongs to the UPF0250 family
C4J93_RS23365	COG1686	Belongs to the peptidase S11 family
C4J93_RS23375	COG2951	lytic endotransglycosylase activity
C4J93_RS23380	COG0772	Belongs to the SEDS family
C4J93_RS23385	COG0768	penicillin binding
C4J93_RS23390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4J93_RS23400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4J93_RS23405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4J93_RS23410	COG2094	Belongs to the DNA glycosylase MPG family
C4J93_RS23415	COG0586	Pfam SNARE associated Golgi protein
C4J93_RS23430	COG1346	cytolysis
C4J93_RS23450	COG0702	epimerase
C4J93_RS23470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J93_RS23475	COG3284	Transcriptional regulator
C4J93_RS23490	COG4303	Ethanolamine ammonia lyase large subunit
C4J93_RS23495	COG4302	ethanolamine ammonia-lyase activity
C4J93_RS23500	COG0456	acetyltransferase
C4J93_RS23505	COG0586	Pfam SNARE associated Golgi protein
C4J93_RS23510	COG3228	Belongs to the MtfA family
C4J93_RS23515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4J93_RS23535	COG1335	isochorismatase
C4J93_RS23555	COG3209	COG3209 Rhs family protein
C4J93_RS23575	COG1722	exodeoxyribonuclease VII activity
C4J93_RS23580	COG0142	geranyltranstransferase activity
C4J93_RS23585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J93_RS23590	COG4206	TonB-dependent receptor
C4J93_RS23605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J93_RS23615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4J93_RS23620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4J93_RS23625	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J93_RS23640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J93_RS23640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J93_RS23645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4J93_RS23655	COG2264	protein methyltransferase activity
C4J93_RS23665	COG3118	belongs to the thioredoxin family
C4J93_RS23705	COG1201	RNA secondary structure unwinding
C4J93_RS23715	COG0668	transmembrane transport
C4J93_RS23725	COG3568	Endonuclease Exonuclease Phosphatase
C4J93_RS23735	COG0392	lysyltransferase activity
C4J93_RS23750	COG1335	isochorismatase
C4J93_RS23755	COG4106	trans-aconitate 2-methyltransferase activity
C4J93_RS23830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J93_RS23835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4J93_RS23875	COG0629	single-stranded DNA binding
C4J93_RS23880	COG2814	Major facilitator Superfamily
C4J93_RS23885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J93_RS23890	COG2193	ferroxidase activity
C4J93_RS23900	COG0203	ribosomal protein L17
C4J93_RS23905	COG0202	RNA polymerase activity
C4J93_RS23910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4J93_RS23915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4J93_RS23920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4J93_RS23925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4J93_RS23935	COG0200	Binds to the 23S rRNA
C4J93_RS23940	COG1841	ribosomal large subunit assembly
C4J93_RS23945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4J93_RS23950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4J93_RS23955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4J93_RS23960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4J93_RS23965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J93_RS23970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4J93_RS23975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4J93_RS23980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4J93_RS23985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4J93_RS23990	COG0255	Belongs to the universal ribosomal protein uL29 family
C4J93_RS23995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4J93_RS24000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4J93_RS24005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4J93_RS24010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4J93_RS24015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4J93_RS24020	COG0089	rRNA binding
C4J93_RS24025	COG0088	Forms part of the polypeptide exit tunnel
C4J93_RS24030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4J93_RS24035	COG0051	transcription antitermination factor activity, RNA binding
C4J93_RS24040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J93_RS24045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J93_RS24050	COG0049	tRNA binding
C4J93_RS24055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4J93_RS24060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4J93_RS24065	COG0085	RNA polymerase activity
C4J93_RS24070	COG0222	ribosome binding
C4J93_RS24075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4J93_RS24080	COG0081	regulation of translation
C4J93_RS24085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4J93_RS24125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4J93_RS24165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4J93_RS24175	COG0739	heme binding
C4J93_RS24180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4J93_RS24185	COG0316	Belongs to the HesB IscA family
C4J93_RS24190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4J93_RS24195	COG1981	membrane
C4J93_RS24210	COG4221	oxidoreductase activity
C4J93_RS24215	COG0537	adenosine 5'-monophosphoramidase activity
C4J93_RS24220	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4J93_RS24225	COG1765	OsmC-like protein
C4J93_RS24240	COG0134	indole-3-glycerol-phosphate synthase activity
C4J93_RS24245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J93_RS24250	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J93_RS24255	COG3240	lipase activity
C4J93_RS24255	COG4625	pathogenesis
C4J93_RS24260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J93_RS24265	COG0546	phosphoglycolate phosphatase activity
C4J93_RS24270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4J93_RS24275	COG1454	alcohol dehydrogenase
C4J93_RS24285	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J93_RS24295	COG3842	ATPase activity
C4J93_RS24300	COG2197	response regulator
C4J93_RS24315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J93_RS24320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4J93_RS24325	COG3178	'Phosphotransferase
C4J93_RS24330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4J93_RS24335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J93_RS24340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4J93_RS24345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J93_RS24350	COG2967	ApaG domain
C4J93_RS24355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J93_RS24360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J93_RS24365	COG2766	serine protein kinase
C4J93_RS24370	COG2718	Belongs to the UPF0229 family
C4J93_RS24375	COG2719	SpoVR family
C4J93_RS24380	COG0617	tRNA 3'-terminal CCA addition
C4J93_RS24390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J93_RS24395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4J93_RS24400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4J93_RS24405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4J93_RS24415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J93_RS24445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J93_RS24450	COG1025	Belongs to the peptidase M16 family
C4J93_RS24460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J93_RS24465	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4J93_RS24475	COG0535	radical SAM domain protein
C4J93_RS24485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J93_RS24490	COG0583	DNA-binding transcription factor activity
C4J93_RS24495	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS24500	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS24510	COG1960	acyl-CoA dehydrogenase activity
C4J93_RS24530	COG1073	alpha beta
C4J93_RS24530	COG2226	methyltransferase
C4J93_RS24535	COG0156	8-amino-7-oxononanoate synthase activity
C4J93_RS24540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4J93_RS24550	COG2005	Transcriptional regulator
C4J93_RS24550	COG3585	molybdate ion transport
C4J93_RS24560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4J93_RS24575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4J93_RS24585	COG4566	intracellular signal transduction
C4J93_RS24585	COG0745	RESPONSE REGULATOR receiver
C4J93_RS24595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J93_RS24605	COG1595	DNA-templated transcription, initiation
C4J93_RS24615	COG4774	siderophore transport
C4J93_RS24640	COG4452	Inner membrane protein CreD
C4J93_RS24645	COG2205	protein histidine kinase activity
C4J93_RS24650	COG0745	RESPONSE REGULATOR receiver
C4J93_RS24655	COG4067	protein conserved in archaea
C4J93_RS24655	COG0189	ligase activity
C4J93_RS24660	COG0204	Acyl-transferase
C4J93_RS24675	COG1063	alcohol dehydrogenase
C4J93_RS24705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J93_RS24725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J93_RS24725	COG1017	nitric oxide dioxygenase activity
C4J93_RS24730	COG4638	Rieske (2fe-2S)
C4J93_RS24740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4J93_RS24745	COG2181	nitrate reductase activity
C4J93_RS24745	COG0247	lactate metabolic process
C4J93_RS24750	COG1902	pentaerythritol trinitrate reductase activity
C4J93_RS24750	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J93_RS24785	COG3246	L-lysine catabolic process to acetate
C4J93_RS24790	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J93_RS24810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4J93_RS24815	COG0493	'glutamate synthase
C4J93_RS24820	COG0067	glutamate synthase
C4J93_RS24820	COG0069	glutamate synthase activity
C4J93_RS24820	COG0070	glutamate synthase
C4J93_RS24835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J93_RS24840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4J93_RS24870	COG0281	malic enzyme
C4J93_RS24880	COG0254	rRNA binding
C4J93_RS24885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4J93_RS24890	COG0018	arginyl-trna synthetase
C4J93_RS24900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4J93_RS24905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4J93_RS24950	COG2226	methyltransferase
C4J93_RS24960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J93_RS24965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J93_RS24970	COG0140	phosphoribosyl-ATP diphosphatase activity
C4J93_RS24975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J93_RS24980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J93_RS25020	COG2116	formate transmembrane transporter activity
C4J93_RS25030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4J93_RS25035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4J93_RS25050	COG0513	Belongs to the DEAD box helicase family
C4J93_RS25055	COG2353	YceI-like domain
C4J93_RS25060	COG3038	cytochrome b561
C4J93_RS25070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4J93_RS25075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS25095	COG1272	protein, Hemolysin III
C4J93_RS25115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4J93_RS25135	COG3052	prosthetic group binding
C4J93_RS25140	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4J93_RS25170	COG3093	addiction module antidote protein HigA
C4J93_RS25180	COG0784	Response regulator, receiver
C4J93_RS25180	COG0643	Histidine kinase
C4J93_RS25180	COG2198	Histidine kinase
C4J93_RS25205	COG0189	ligase activity
C4J93_RS25215	COG1678	Uncharacterized ACR, COG1678
C4J93_RS25220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4J93_RS25225	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4J93_RS25230	COG0540	Belongs to the ATCase OTCase family
C4J93_RS25235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J93_RS25245	COG0791	NLP P60 protein
C4J93_RS25270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J93_RS25275	COG2813	Specifically methylates the guanine in position
C4J93_RS25275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J93_RS25285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4J93_RS25290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4J93_RS25300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4J93_RS25305	COG2022	thiamine diphosphate biosynthetic process
C4J93_RS25315	COG2363	Small membrane protein
C4J93_RS25320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J93_RS25330	COG2177	Part of the ABC transporter FtsEX involved in
C4J93_RS25335	COG2884	Cell division ATP-binding protein ftsE
C4J93_RS25340	COG0552	protein localization to endoplasmic reticulum
C4J93_RS25345	COG0612	Peptidase, M16
C4J93_RS25350	COG0612	Peptidase, M16
C4J93_RS25355	COG0742	ribosomal rna small subunit methyltransferase
C4J93_RS25360	COG0429	hydrolase of the alpha beta-hydrolase fold
C4J93_RS25380	COG1309	transcriptional regulator
C4J93_RS25395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J93_RS25400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4J93_RS25405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J93_RS25410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J93_RS25420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J93_RS25425	COG0129	dihydroxy-acid dehydratase activity
C4J93_RS25435	COG1823	symporter activity
C4J93_RS25450	COG1160	GTP binding
C4J93_RS25460	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J93_RS25465	COG1178	ABC-type Fe3 transport system permease component
C4J93_RS25470	COG3842	ATPase activity
C4J93_RS25475	COG0583	DNA-binding transcription factor activity
C4J93_RS25485	COG0789	Transcriptional regulator
C4J93_RS25490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4J93_RS25495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4J93_RS25510	COG0494	nUDIX hydrolase
C4J93_RS25530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J93_RS25535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4J93_RS25540	COG2234	aminopeptidase activity
C4J93_RS25545	COG3204	pilus organization
C4J93_RS25550	COG3204	pilus organization
C4J93_RS25555	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J93_RS25560	COG0277	FAD linked oxidase domain protein
C4J93_RS25570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J93_RS25580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS25620	COG1177	transmembrane transport
C4J93_RS25625	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J93_RS25630	COG3842	ATPase activity
C4J93_RS25650	COG0174	glutamine synthetase
C4J93_RS25655	COG0174	glutamine synthetase
C4J93_RS25675	COG1116	anion transmembrane transporter activity
C4J93_RS25680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J93_RS25690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J93_RS25695	COG0431	NADPH-dependent FMN reductase
C4J93_RS25700	COG0450	alkyl hydroperoxide reductase
C4J93_RS25710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J93_RS25710	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4J93_RS25725	COG1522	sequence-specific DNA binding
C4J93_RS25735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J93_RS25740	COG0330	HflC and HflK could
C4J93_RS25755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J93_RS25760	COG0509	glycine decarboxylation via glycine cleavage system
C4J93_RS25765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J93_RS25770	COG1178	ABC-type Fe3 transport system permease component
C4J93_RS25780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J93_RS25790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J93_RS25795	COG0006	proline dipeptidase activity
C4J93_RS25800	COG3079	Belongs to the UPF0149 family
C4J93_RS25820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4J93_RS25845	COG2271	Major facilitator Superfamily
C4J93_RS25865	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4J93_RS25885	COG2186	Transcriptional regulator
C4J93_RS25890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS25895	COG0765	amino acid transport
C4J93_RS25900	COG0765	amino acid transport
C4J93_RS25905	COG1126	abc transporter atp-binding protein
C4J93_RS25915	COG3188	usher protein
C4J93_RS25920	COG3121	Chaperone
C4J93_RS25935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4J93_RS25945	COG0586	Pfam SNARE associated Golgi protein
C4J93_RS25955	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4J93_RS25960	COG1671	Belongs to the UPF0178 family
C4J93_RS25965	COG0672	)-iron permease
C4J93_RS25970	COG1280	lysine exporter protein (LysE YggA)
C4J93_RS25980	COG0488	(ABC) transporter
C4J93_RS26005	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J93_RS26020	COG0181	hydroxymethylbilane synthase activity
C4J93_RS26030	COG0165	Argininosuccinate lyase
C4J93_RS26035	COG0625	glutathione transferase activity
C4J93_RS26055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J93_RS26065	COG1965	Belongs to the frataxin family
C4J93_RS26075	COG0019	diaminopimelate decarboxylase activity
C4J93_RS26080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J93_RS26090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J93_RS26095	COG1011	Hydrolase
C4J93_RS26105	COG0432	Pfam Uncharacterised protein family UPF0047
C4J93_RS26110	COG0004	ammonium transporteR
C4J93_RS26115	COG0347	Belongs to the P(II) protein family
C4J93_RS26125	COG0606	chelatase, subunit chli
C4J93_RS26130	COG0840	transmembrane signaling receptor activity
C4J93_RS26135	COG0583	DNA-binding transcription factor activity
C4J93_RS26140	COG0534	Mate efflux family protein
C4J93_RS26155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J93_RS26180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4J93_RS26185	COG0251	oxidation-reduction process
C4J93_RS26190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS26205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J93_RS26215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J93_RS26220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J93_RS26230	COG1012	belongs to the aldehyde dehydrogenase family
C4J93_RS26240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J93_RS26245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J93_RS26250	COG0747	negative chemotaxis
C4J93_RS26255	COG2003	Belongs to the UPF0758 family
C4J93_RS26260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4J93_RS26265	COG0756	dUTP diphosphatase activity
C4J93_RS26280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J93_RS26285	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4J93_RS26290	COG0708	Exodeoxyribonuclease III
C4J93_RS26300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4J93_RS26305	COG1561	YicC-like family, N-terminal region
C4J93_RS26310	COG0194	GDP metabolic process
C4J93_RS26315	COG1758	RNA polymerase activity
C4J93_RS26320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J93_RS26345	COG0848	biopolymer transport protein
C4J93_RS26355	COG0583	DNA-binding transcription factor activity
C4J93_RS26360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4J93_RS26405	COG0515	serine threonine protein kinase
C4J93_RS26405	COG2815	serine threonine protein kinase
C4J93_RS26410	COG0631	protein serine/threonine phosphatase activity
C4J93_RS26520	COG3161	chorismate lyase activity
C4J93_RS26525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4J93_RS26545	COG1253	flavin adenine dinucleotide binding
C4J93_RS26555	COG0704	Plays a role in the regulation of phosphate uptake
C4J93_RS26560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J93_RS26590	COG0477	Major facilitator Superfamily
C4J93_RS26595	COG1607	acyl-coa hydrolase
C4J93_RS26625	COG0583	DNA-binding transcription factor activity
C4J93_RS26630	COG1027	Aspartate ammonia-lyase
C4J93_RS26635	COG1115	amino acid carrier protein
C4J93_RS26640	COG0252	asparaginase activity
C4J93_RS26675	COG2808	Putative FMN-binding domain
C4J93_RS26695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J93_RS26700	COG0765	amino acid transport
C4J93_RS26720	COG0511	ligase activity, forming carbon-carbon bonds
C4J93_RS26720	COG5016	pyruvate
C4J93_RS26725	COG0439	Biotin carboxylase
C4J93_RS26730	COG0583	DNA-binding transcription factor activity
C4J93_RS26745	COG5001	Diguanylate cyclase
C4J93_RS26745	COG3300	MHYT domain
C4J93_RS26750	COG0210	DNA helicase
C4J93_RS26765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J93_RS26765	COG4651	solute:proton antiporter activity
C4J93_RS26770	COG1607	acyl-coa hydrolase
C4J93_RS26775	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4J93_RS26785	COG0523	cobalamin synthesis protein
C4J93_RS26805	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J93_RS26810	COG1469	GTP cyclohydrolase I activity
C4J93_RS26815	COG1121	(ABC) transporter
C4J93_RS26840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J93_RS26880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4J93_RS26885	COG2267	carboxylic ester hydrolase activity
C4J93_RS26890	COG0671	phosphoesterase, PA-phosphatase related
C4J93_RS26890	COG2453	phosphatase
C4J93_RS26905	COG4589	Belongs to the CDS family
C4J93_RS26915	COG1309	transcriptional regulator
C4J93_RS26930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J93_RS26935	COG1349	DNA-binding transcription factor activity
C4J93_RS26940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J93_RS26950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4J93_RS26955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4J93_RS26960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4J93_RS26965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4J93_RS26970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J93_RS26975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4J93_RS26985	COG0356	it plays a direct role in the translocation of protons across the membrane
C4J93_RS26990	COG3312	ion transport
C4J93_RS26995	COG1475	DNA binding
C4J93_RS27000	COG1192	Involved in chromosome partitioning
C4J93_RS27005	COG0357	Ribosomal RNA small subunit methyltransferase G
C4J93_RS27010	COG0445	tRNA wobble uridine modification
C4J93_RS27015	COG1595	DNA-templated transcription, initiation
C4J93_RS27025	COG4774	siderophore transport
C4J93_RS27035	COG0706	membrane insertase activity
C4J93_RS27040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4J93_RS27045	COG0594	ribonuclease P activity
C4J93_RS27050	COG0230	Belongs to the bacterial ribosomal protein bL34 family