locus-tag	class	description
C4J89_RS00010	COG0592	DNA-directed DNA polymerase activity
C4J89_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J89_RS00020	COG0187	DNA topoisomerase II activity
C4J89_RS00025	COG0745	RESPONSE REGULATOR receiver
C4J89_RS00030	COG5002	protein histidine kinase activity
C4J89_RS00040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4J89_RS00045	COG0751	glycine-tRNA ligase activity
C4J89_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
C4J89_RS00055	COG2818	Glycosylase
C4J89_RS00070	COG0569	domain protein
C4J89_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4J89_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J89_RS00085	COG0242	peptide deformylase activity
C4J89_RS00095	COG0758	DNA mediated transformation
C4J89_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
C4J89_RS00110	COG0408	coproporphyrinogen oxidase activity
C4J89_RS00115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J89_RS00135	COG3119	arylsulfatase activity
C4J89_RS00140	COG0583	DNA-binding transcription factor activity
C4J89_RS00150	COG3734	2-keto-3-deoxy-galactonokinase
C4J89_RS00155	COG0800	Aldolase
C4J89_RS00160	COG4948	Mandelate Racemase Muconate Lactonizing
C4J89_RS00165	COG2271	Major facilitator Superfamily
C4J89_RS00170	COG0159	tryptophan synthase activity
C4J89_RS00190	COG3360	Dodecin
C4J89_RS00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J89_RS00205	COG1764	response to oxidative stress
C4J89_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4J89_RS00240	COG0339	signal peptide processing
C4J89_RS00275	COG0659	secondary active sulfate transmembrane transporter activity
C4J89_RS00285	COG1565	acr, cog1565
C4J89_RS00285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J89_RS00290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J89_RS00295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4J89_RS00325	COG0109	protoheme IX farnesyltransferase activity
C4J89_RS00340	COG2011	ABC-type metal ion transport system permease component
C4J89_RS00345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J89_RS00360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J89_RS00365	COG1121	(ABC) transporter
C4J89_RS00370	COG0735	belongs to the Fur family
C4J89_RS00375	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4J89_RS00395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4J89_RS00410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4J89_RS00425	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J89_RS00430	COG5002	protein histidine kinase activity
C4J89_RS00435	COG2204	response regulator
C4J89_RS00445	COG5487	UPF0391 membrane protein
C4J89_RS00455	COG1301	dicarboxylic acid transport
C4J89_RS00460	COG0700	Nucleoside recognition
C4J89_RS00475	COG1127	ABC transporter
C4J89_RS00480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J89_RS00490	COG0612	Peptidase, M16
C4J89_RS00495	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4J89_RS00500	COG0861	Integral membrane protein TerC family
C4J89_RS00505	COG2851	Citrate transporter
C4J89_RS00535	COG0427	acetyl-CoA hydrolase
C4J89_RS00555	COG0583	DNA-binding transcription factor activity
C4J89_RS00560	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS00565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J89_RS00605	COG0840	transmembrane signaling receptor activity
C4J89_RS00635	COG3300	MHYT domain
C4J89_RS00635	COG5001	Diguanylate cyclase
C4J89_RS00655	COG2274	protein secretion by the type I secretion system
C4J89_RS00660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS00665	COG2175	clavaminate synthase activity
C4J89_RS00760	COG0529	Catalyzes the synthesis of activated sulfate
C4J89_RS00775	COG1289	transmembrane transporter activity
C4J89_RS00800	COG5339	Protein conserved in bacteria
C4J89_RS00805	COG0457	Tetratricopeptide repeat
C4J89_RS00810	COG1649	PFAM Uncharacterised BCR, COG1649
C4J89_RS00810	COG0726	polysaccharide deacetylase
C4J89_RS00815	COG1215	transferase activity, transferring glycosyl groups
C4J89_RS00900	COG2304	oxidoreductase activity
C4J89_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS00975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J89_RS00985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J89_RS00990	COG2199	diguanylate cyclase activity
C4J89_RS01010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J89_RS01020	COG4208	sulfate ABC transporter
C4J89_RS01025	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4J89_RS01035	COG2351	hydroxyisourate hydrolase activity
C4J89_RS01065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J89_RS01070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J89_RS01100	COG4771	TonB-dependent receptor
C4J89_RS01105	COG2807	transmembrane transport
C4J89_RS01140	COG0765	amino acid transport
C4J89_RS01145	COG0765	amino acid transport
C4J89_RS01150	COG1126	abc transporter atp-binding protein
C4J89_RS01155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS01160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J89_RS01190	COG2011	ABC-type metal ion transport system permease component
C4J89_RS01195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J89_RS01200	COG1464	Belongs to the NlpA lipoprotein family
C4J89_RS01225	COG1126	abc transporter atp-binding protein
C4J89_RS01230	COG0765	amino acid transport
C4J89_RS01235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS01245	COG1045	serine acetyltransferase
C4J89_RS01250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J89_RS01255	COG0667	Aldo Keto reductase
C4J89_RS01260	COG2175	clavaminate synthase activity
C4J89_RS01265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J89_RS01270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4J89_RS01275	COG4521	taurine ABC transporter
C4J89_RS01280	COG2918	glutathione biosynthetic process
C4J89_RS01290	COG2183	response to ionizing radiation
C4J89_RS01305	COG0189	ligase activity
C4J89_RS01310	COG0189	ligase activity
C4J89_RS01310	COG4067	protein conserved in archaea
C4J89_RS01315	COG2200	EAL domain
C4J89_RS01320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4J89_RS01330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4J89_RS01335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4J89_RS01385	COG0514	ATP-dependent DNA helicase (RecQ)
C4J89_RS01390	COG0824	Thioesterase
C4J89_RS01400	COG0243	molybdopterin cofactor binding
C4J89_RS01405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4J89_RS01410	COG1652	LysM domain
C4J89_RS01415	COG1011	Hydrolase
C4J89_RS01420	COG0494	nUDIX hydrolase
C4J89_RS01425	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4J89_RS01465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J89_RS01470	COG2957	Belongs to the agmatine deiminase family
C4J89_RS01510	COG1309	transcriptional regulator
C4J89_RS01560	COG5002	protein histidine kinase activity
C4J89_RS01600	COG2894	cell division
C4J89_RS01655	COG3210	domain, Protein
C4J89_RS01695	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4J89_RS01700	COG1194	a g-specific adenine glycosylase
C4J89_RS01710	COG2223	nitrite transmembrane transporter activity
C4J89_RS01715	COG0131	Imidazoleglycerol-phosphate dehydratase
C4J89_RS01720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4J89_RS01730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4J89_RS01735	COG0107	imidazoleglycerol-phosphate synthase activity
C4J89_RS01745	COG2861	carbohydrate metabolic process
C4J89_RS01750	COG0793	Belongs to the peptidase S41A family
C4J89_RS01755	COG4942	peptidase
C4J89_RS01765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4J89_RS01770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J89_RS01780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4J89_RS01805	COG3852	Histidine kinase
C4J89_RS01825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J89_RS01825	COG0301	tRNA thio-modification
C4J89_RS01830	COG1217	gtp-binding protein TYPA
C4J89_RS01845	COG0058	SHG alpha-glucan phosphorylase activity
C4J89_RS01850	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4J89_RS01865	COG0402	S-adenosylhomocysteine deaminase activity
C4J89_RS01870	COG2188	Transcriptional regulator
C4J89_RS01880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4J89_RS01885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J89_RS01895	COG4176	ABC-type proline glycine betaine transport system permease component
C4J89_RS01900	COG4175	Glycine betaine
C4J89_RS01900	COG0517	IMP dehydrogenase activity
C4J89_RS01905	COG2986	histidine ammonia-lyase
C4J89_RS01910	COG2986	histidine ammonia-lyase
C4J89_RS01920	COG1228	amidohydrolase
C4J89_RS01930	COG0675	Transposase, IS605 OrfB family
C4J89_RS01935	COG0596	Alpha beta hydrolase
C4J89_RS01940	COG1490	D-aminoacyl-tRNA deacylase activity
C4J89_RS01945	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J89_RS01950	COG2943	transferase activity, transferring hexosyl groups
C4J89_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS01965	COG0765	amino acid transport
C4J89_RS01970	COG1126	abc transporter atp-binding protein
C4J89_RS01975	COG0840	transmembrane signaling receptor activity
C4J89_RS01980	COG0840	transmembrane signaling receptor activity
C4J89_RS01995	COG1422	Protein of unknown function (DUF1090)
C4J89_RS02000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J89_RS02010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4J89_RS02015	COG0640	Transcriptional regulator
C4J89_RS02020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4J89_RS02025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4J89_RS02030	COG0126	phosphoglycerate kinase activity
C4J89_RS02060	COG1451	nucleotide metabolic process
C4J89_RS02070	COG2153	protein acetylation
C4J89_RS02080	COG1289	transmembrane transporter activity
C4J89_RS02090	COG2081	HI0933 family
C4J89_RS02095	COG0513	Belongs to the DEAD box helicase family
C4J89_RS02100	COG0477	Major facilitator Superfamily
C4J89_RS02120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J89_RS02125	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS02130	COG1309	transcriptional regulator
C4J89_RS02135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J89_RS02140	COG4175	Glycine betaine
C4J89_RS02155	COG1760	l-serine dehydratase
C4J89_RS02160	COG2814	Major facilitator Superfamily
C4J89_RS02165	COG0583	DNA-binding transcription factor activity
C4J89_RS02180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J89_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS02195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J89_RS02205	COG2226	methyltransferase
C4J89_RS02230	COG2986	histidine ammonia-lyase
C4J89_RS02245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J89_RS02255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J89_RS02260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J89_RS02275	COG1192	Involved in chromosome partitioning
C4J89_RS02285	COG3118	belongs to the thioredoxin family
C4J89_RS02300	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4J89_RS02305	COG1196	nuclear chromosome segregation
C4J89_RS02305	COG3264	Mechanosensitive ion channel
C4J89_RS02310	COG3263	regulation of cellular component size
C4J89_RS02330	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS02335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J89_RS02335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J89_RS02335	COG0506	proline dehydrogenase activity
C4J89_RS02340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J89_RS02355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4J89_RS02360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J89_RS02380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J89_RS02385	COG0859	PFAM glycosyl transferase family 9
C4J89_RS02390	COG0859	PFAM glycosyl transferase family 9
C4J89_RS02395	COG0438	transferase activity, transferring glycosyl groups
C4J89_RS02420	COG4772	TonB-dependent receptor
C4J89_RS02430	COG2192	nodulation
C4J89_RS02445	COG0438	transferase activity, transferring glycosyl groups
C4J89_RS02450	COG1215	transferase activity, transferring glycosyl groups
C4J89_RS02460	COG1132	(ABC) transporter
C4J89_RS02465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4J89_RS02465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4J89_RS02470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J89_RS02480	COG0667	Aldo Keto reductase
C4J89_RS02495	COG0583	DNA-binding transcription factor activity
C4J89_RS02500	COG1519	Transferase
C4J89_RS02505	COG1538	Outer membrane efflux protein
C4J89_RS02510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4J89_RS02525	COG0494	nUDIX hydrolase
C4J89_RS02535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J89_RS02555	COG3150	esterase
C4J89_RS02590	COG0688	phosphatidylethanolamine metabolic process
C4J89_RS02620	COG1162	GTPase activity
C4J89_RS02625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4J89_RS02630	COG2860	membrane
C4J89_RS02640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4J89_RS02640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4J89_RS02645	COG0802	atpase or kinase
C4J89_RS02650	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J89_RS02655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4J89_RS02660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4J89_RS02665	COG1923	regulation of RNA biosynthetic process
C4J89_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4J89_RS02675	COG0330	HflC and HflK could
C4J89_RS02680	COG0330	HflC and HflK could
C4J89_RS02685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4J89_RS02690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4J89_RS02700	COG1178	ABC-type Fe3 transport system permease component
C4J89_RS02705	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J89_RS02720	COG0557	exoribonuclease II activity
C4J89_RS02725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J89_RS02730	COG0360	Binds together with S18 to 16S ribosomal RNA
C4J89_RS02735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J89_RS02745	COG0359	binds to the 23S rRNA
C4J89_RS02750	COG0305	Participates in initiation and elongation during chromosome replication
C4J89_RS02760	COG1032	radical SAM domain protein
C4J89_RS02790	COG2308	Evidence 4 Homologs of previously reported genes of
C4J89_RS02790	COG2307	Protein conserved in bacteria
C4J89_RS02810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J89_RS02815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4J89_RS02820	COG0583	DNA-binding transcription factor activity
C4J89_RS02825	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS02830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS02840	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS02865	COG4221	oxidoreductase activity
C4J89_RS02885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4J89_RS02890	COG0830	nickel cation binding
C4J89_RS02895	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4J89_RS02900	COG0791	NLP P60 protein
C4J89_RS02905	COG1309	transcriptional regulator
C4J89_RS02915	COG2982	Protein involved in outer membrane biogenesis
C4J89_RS02935	COG0443	Heat shock 70 kDa protein
C4J89_RS02940	COG0484	heat shock protein binding
C4J89_RS02945	COG0804	urea catabolic process
C4J89_RS02950	COG0832	Belongs to the urease beta subunit family
C4J89_RS02965	COG0831	urea catabolic process
C4J89_RS02970	COG0829	nickel cation binding
C4J89_RS02980	COG0411	ABC transporter
C4J89_RS03025	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J89_RS03030	COG3657	addiction module killer protein
C4J89_RS03075	COG2095	MarC family integral membrane protein
C4J89_RS03085	COG0151	Belongs to the GarS family
C4J89_RS03090	COG0138	bifunctional purine biosynthesis protein purh
C4J89_RS03100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J89_RS03115	COG2264	protein methyltransferase activity
C4J89_RS03130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J89_RS03155	COG0023	Translation Initiation Factor
C4J89_RS03160	COG1166	arginine decarboxylase activity
C4J89_RS03165	COG0534	Mate efflux family protein
C4J89_RS03170	COG2373	Large extracellular alpha-helical protein
C4J89_RS03180	COG4953	penicillin-binding protein 1C
C4J89_RS03190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J89_RS03260	COG4964	Belongs to the GSP D family
C4J89_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS03315	COG2217	Heavy metal translocating P-type atpase
C4J89_RS03335	COG2814	Major facilitator Superfamily
C4J89_RS03340	COG0604	alcohol dehydrogenase
C4J89_RS03345	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4J89_RS03350	COG0583	DNA-binding transcription factor activity
C4J89_RS03360	COG0477	Major facilitator Superfamily
C4J89_RS03365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J89_RS03370	COG0387	Pfam Sodium calcium exchanger
C4J89_RS03390	COG1309	transcriptional regulator
C4J89_RS03395	COG2233	PERMEase
C4J89_RS03445	COG2995	paraquat-inducible protein a
C4J89_RS03450	COG2995	paraquat-inducible protein a
C4J89_RS03455	COG3008	intermembrane lipid transfer
C4J89_RS03480	COG0456	acetyltransferase
C4J89_RS03490	COG0288	reversible hydration of carbon dioxide
C4J89_RS03520	COG2031	fatty acid transporter
C4J89_RS03525	COG0477	Major facilitator Superfamily
C4J89_RS03545	COG0405	Gamma-glutamyltransferase
C4J89_RS03580	COG1157	protein secretion by the type III secretion system
C4J89_RS03605	COG4794	Type iii secretion
C4J89_RS03615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J89_RS03655	COG4669	(LipO)protein
C4J89_RS03680	COG0193	aminoacyl-tRNA hydrolase activity
C4J89_RS03685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4J89_RS03690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J89_RS03700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4J89_RS03705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4J89_RS03715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4J89_RS03720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4J89_RS03730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4J89_RS03735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4J89_RS03755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J89_RS03770	COG4221	oxidoreductase activity
C4J89_RS03775	COG0415	Belongs to the DNA photolyase family
C4J89_RS03780	COG0789	Transcriptional regulator
C4J89_RS03795	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4J89_RS03800	COG1090	epimerase
C4J89_RS03805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4J89_RS03815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J89_RS03830	COG0175	sulfate reduction
C4J89_RS03840	COG0204	Acyl-transferase
C4J89_RS03845	COG0857	belongs to the CobB CobQ family
C4J89_RS03845	COG0280	phosphate acetyltransferase
C4J89_RS03860	COG0268	Binds directly to 16S ribosomal RNA
C4J89_RS03870	COG0196	riboflavin kinase activity
C4J89_RS03875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4J89_RS03880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J89_RS03885	COG1047	Peptidyl-prolyl cis-trans
C4J89_RS03890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4J89_RS03920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS03945	COG0542	response to heat
C4J89_RS03970	COG1252	NADH dehydrogenase
C4J89_RS03995	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4J89_RS04000	COG0237	dephospho-CoA kinase activity
C4J89_RS04040	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J89_RS04060	COG0084	hydrolase, TatD family'
C4J89_RS04065	COG1609	Transcriptional regulator
C4J89_RS04075	COG1105	Belongs to the carbohydrate kinase PfkB family
C4J89_RS04080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4J89_RS04080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J89_RS04080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J89_RS04090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4J89_RS04095	COG4774	siderophore transport
C4J89_RS04100	COG3128	pkhd-type hydroxylase
C4J89_RS04110	COG0019	diaminopimelate decarboxylase activity
C4J89_RS04135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4J89_RS04175	COG0667	Aldo Keto reductase
C4J89_RS04225	COG4608	Belongs to the ABC transporter superfamily
C4J89_RS04230	COG0444	Belongs to the ABC transporter superfamily
C4J89_RS04235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J89_RS04240	COG0601	transmembrane transport
C4J89_RS04245	COG0747	negative chemotaxis
C4J89_RS04255	COG0747	negative chemotaxis
C4J89_RS04260	COG0747	negative chemotaxis
C4J89_RS04265	COG0747	negative chemotaxis
C4J89_RS04280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4J89_RS04285	COG4178	(ABC) transporter
C4J89_RS04300	COG0180	Tryptophanyl-tRNA synthetase
C4J89_RS04305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J89_RS04315	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS04325	COG0667	Aldo Keto reductase
C4J89_RS04330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4J89_RS04335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4J89_RS04340	COG0723	plastoquinol--plastocyanin reductase activity
C4J89_RS04345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J89_RS04350	COG2857	Cytochrome c1
C4J89_RS04355	COG0625	glutathione transferase activity
C4J89_RS04360	COG2969	positive regulation of protein catabolic process
C4J89_RS04365	COG2186	Transcriptional regulator
C4J89_RS04380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J89_RS04390	COG2271	Major facilitator Superfamily
C4J89_RS04395	COG2721	sulfolactate sulfo-lyase activity
C4J89_RS04410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J89_RS04415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J89_RS04420	COG0154	amidase activity
C4J89_RS04425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J89_RS04430	COG1077	Cell shape determining protein MreB Mrl
C4J89_RS04435	COG1792	Involved in formation and maintenance of cell shape
C4J89_RS04445	COG0424	maF-like protein
C4J89_RS04450	COG1530	ribonuclease E activity
C4J89_RS04460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J89_RS04465	COG0312	modulator of DNA gyrase
C4J89_RS04470	COG3028	Belongs to the UPF0307 family
C4J89_RS04475	COG0312	modulator of DNA gyrase
C4J89_RS04505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J89_RS04510	COG1660	Displays ATPase and GTPase activities
C4J89_RS04520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4J89_RS04525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4J89_RS04530	COG1137	ATPase activity
C4J89_RS04535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4J89_RS04545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4J89_RS04555	COG1127	ABC transporter
C4J89_RS04560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J89_RS04565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4J89_RS04585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J89_RS04595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4J89_RS04600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4J89_RS04605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J89_RS04615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4J89_RS04620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4J89_RS04675	COG2135	peptidase activity
C4J89_RS04680	COG0501	Belongs to the peptidase M48B family
C4J89_RS04685	COG2119	membrane
C4J89_RS04690	COG2813	Specifically methylates the guanine in position
C4J89_RS04695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J89_RS04700	COG1280	lysine exporter protein (LysE YggA)
C4J89_RS04705	COG0318	PFAM AMP-dependent synthetase and ligase
C4J89_RS04735	COG3008	intermembrane lipid transfer
C4J89_RS04740	COG2995	paraquat-inducible protein a
C4J89_RS04750	COG2885	chlorophyll binding
C4J89_RS04755	COG2823	Periplasmic or secreted lipoprotein
C4J89_RS04760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4J89_RS04765	COG0792	nuclease activity
C4J89_RS04785	COG2001	Belongs to the MraZ family
C4J89_RS04790	COG0275	rRNA processing
C4J89_RS04805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J89_RS04810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4J89_RS04815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J89_RS04820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J89_RS04825	COG0772	Belongs to the SEDS family
C4J89_RS04830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J89_RS04835	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J89_RS04840	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J89_RS04855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4J89_RS04860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4J89_RS04865	COG2203	Gaf domain
C4J89_RS04865	COG5001	Diguanylate cyclase
C4J89_RS04865	COG4251	negative regulation of phosphorylation
C4J89_RS04865	COG3706	GGDEF domain
C4J89_RS04875	COG5002	protein histidine kinase activity
C4J89_RS04915	COG0784	Response regulator, receiver
C4J89_RS04915	COG0835	chemotaxis
C4J89_RS04925	COG0583	DNA-binding transcription factor activity
C4J89_RS04945	COG1566	PFAM secretion protein HlyD family protein
C4J89_RS04955	COG0300	oxidoreductase activity
C4J89_RS04970	COG0662	Cupin 2, conserved barrel domain protein
C4J89_RS04970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J89_RS04985	COG1696	Membrane protein involved in D-alanine export
C4J89_RS05000	COG3420	alginic acid biosynthetic process
C4J89_RS05010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4J89_RS05020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS05030	COG1215	transferase activity, transferring glycosyl groups
C4J89_RS05040	COG3022	response to hydroperoxide
C4J89_RS05050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4J89_RS05055	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J89_RS05060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4J89_RS05080	COG0513	Belongs to the DEAD box helicase family
C4J89_RS05090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS05095	COG4597	amino acid ABC transporter
C4J89_RS05100	COG0765	amino acid transport
C4J89_RS05105	COG1126	abc transporter atp-binding protein
C4J89_RS05115	COG2186	Transcriptional regulator
C4J89_RS05120	COG2807	transmembrane transport
C4J89_RS05125	COG2205	protein histidine kinase activity
C4J89_RS05125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS05140	COG2827	Endonuclease containing a URI domain
C4J89_RS05145	COG4774	siderophore transport
C4J89_RS05150	COG2027	D-alanyl-D-alanine carboxypeptidase
C4J89_RS05160	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4J89_RS05165	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J89_RS05185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4J89_RS05215	COG1760	l-serine dehydratase
C4J89_RS05220	COG0583	DNA-binding transcription factor activity
C4J89_RS05230	COG0477	Major facilitator Superfamily
C4J89_RS05240	COG4772	TonB-dependent receptor
C4J89_RS05245	COG3712	iron ion homeostasis
C4J89_RS05250	COG1595	DNA-templated transcription, initiation
C4J89_RS05285	COG3081	Nucleoid-associated protein
C4J89_RS05295	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4J89_RS05300	COG0525	valine-tRNA ligase activity
C4J89_RS05315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4J89_RS05320	COG0795	lipopolysaccharide-transporting ATPase activity
C4J89_RS05325	COG0795	lipopolysaccharide-transporting ATPase activity
C4J89_RS05330	COG0481	GTPase activity
C4J89_RS05335	COG0681	Belongs to the peptidase S26 family
C4J89_RS05340	COG0571	ribonuclease III activity
C4J89_RS05345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4J89_RS05350	COG1381	Involved in DNA repair and RecF pathway recombination
C4J89_RS05355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4J89_RS05365	COG0590	tRNA wobble adenosine to inosine editing
C4J89_RS05370	COG0500	methyltransferase
C4J89_RS05375	COG2226	methyltransferase
C4J89_RS05390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J89_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS05430	COG0523	cobalamin synthesis protein
C4J89_RS05445	COG4206	TonB-dependent receptor
C4J89_RS05450	COG4628	conserved protein (DUF2132)
C4J89_RS05470	COG1695	Transcriptional regulator
C4J89_RS05520	COG1113	amino acid transport
C4J89_RS05530	COG0069	glutamate synthase activity
C4J89_RS05545	COG5002	protein histidine kinase activity
C4J89_RS05550	COG1858	cytochrome C peroxidase
C4J89_RS05565	COG0494	nUDIX hydrolase
C4J89_RS05585	COG0583	DNA-binding transcription factor activity
C4J89_RS05610	COG2076	Multidrug Resistance protein
C4J89_RS05625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J89_RS05640	COG4191	Histidine kinase
C4J89_RS05645	COG2204	response regulator
C4J89_RS05665	COG1126	abc transporter atp-binding protein
C4J89_RS05670	COG0765	amino acid transport
C4J89_RS05675	COG0765	amino acid transport
C4J89_RS05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS05695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J89_RS05705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4J89_RS05710	COG3842	ATPase activity
C4J89_RS05715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4J89_RS05725	COG0243	molybdopterin cofactor binding
C4J89_RS05730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4J89_RS05745	COG0450	alkyl hydroperoxide reductase
C4J89_RS05750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J89_RS05755	COG0418	dihydroorotase activity
C4J89_RS05765	COG0137	argininosuccinate synthase activity
C4J89_RS05775	COG2197	response regulator
C4J89_RS05785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4J89_RS05790	COG2878	Part of a membrane complex involved in electron transport
C4J89_RS05795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J89_RS05795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J89_RS05800	COG0489	protein tyrosine kinase activity
C4J89_RS05810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4J89_RS05910	COG3179	chitinase
C4J89_RS05920	COG1546	Belongs to the CinA family
C4J89_RS05925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4J89_RS05930	COG2137	regulation of response to DNA damage stimulus
C4J89_RS05945	COG3148	PFAM DTW domain containing protein
C4J89_RS05960	COG0583	DNA-binding transcription factor activity
C4J89_RS05975	COG4807	Protein conserved in bacteria
C4J89_RS05985	COG0519	Catalyzes the synthesis of GMP from XMP
C4J89_RS05990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J89_RS06010	COG3158	transport of potassium into the cell
C4J89_RS06015	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS06025	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J89_RS06045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J89_RS06045	COG0457	Tetratricopeptide repeat
C4J89_RS06060	COG2201	protein-glutamate methylesterase activity
C4J89_RS06065	COG2203	Gaf domain
C4J89_RS06065	COG3706	GGDEF domain
C4J89_RS06065	COG4251	negative regulation of phosphorylation
C4J89_RS06065	COG5001	Diguanylate cyclase
C4J89_RS06075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4J89_RS06090	COG1073	alpha beta
C4J89_RS06110	COG2885	chlorophyll binding
C4J89_RS06125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4J89_RS06130	COG0563	adenylate kinase activity
C4J89_RS06135	COG1214	PFAM Peptidase M22, glycoprotease
C4J89_RS06145	COG1801	Protein of unknown function DUF72
C4J89_RS06165	COG0742	ribosomal rna small subunit methyltransferase
C4J89_RS06175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS06200	COG2937	Belongs to the GPAT DAPAT family
C4J89_RS06215	COG2226	methyltransferase
C4J89_RS06220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J89_RS06225	COG1215	transferase activity, transferring glycosyl groups
C4J89_RS06230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4J89_RS06235	COG2166	iron-sulfur cluster assembly
C4J89_RS06240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J89_RS06245	COG2171	N-acyltransferase activity
C4J89_RS06250	COG1393	Belongs to the ArsC family
C4J89_RS06255	COG0025	NhaP-type Na H and K H
C4J89_RS06270	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4J89_RS06280	COG0052	Belongs to the universal ribosomal protein uS2 family
C4J89_RS06285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4J89_RS06290	COG0528	UMP kinase activity
C4J89_RS06295	COG0233	cytoplasmic translational termination
C4J89_RS06300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J89_RS06310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4J89_RS06330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J89_RS06335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J89_RS06340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J89_RS06345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J89_RS06350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4J89_RS06355	COG0587	DNA-directed DNA polymerase activity
C4J89_RS06360	COG0825	malonyl-CoA metabolic process
C4J89_RS06365	COG0037	tRNA processing
C4J89_RS06370	COG0504	CTP synthase activity
C4J89_RS06375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4J89_RS06380	COG0148	phosphopyruvate hydratase activity
C4J89_RS06390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4J89_RS06400	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4J89_RS06405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4J89_RS06410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4J89_RS06415	COG0585	pseudouridine synthase activity
C4J89_RS06420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4J89_RS06425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4J89_RS06440	COG1278	Cold shock
C4J89_RS06445	COG0717	Belongs to the dCTP deaminase family
C4J89_RS06460	COG1201	RNA secondary structure unwinding
C4J89_RS06465	COG4598	ABC transporter
C4J89_RS06475	COG4160	amino acid transport
C4J89_RS06490	COG1793	dna ligase
C4J89_RS06500	COG2366	antibiotic biosynthetic process
C4J89_RS06505	COG0653	protein targeting
C4J89_RS06515	COG3012	SEC-C Motif Domain Protein
C4J89_RS06535	COG1199	ATP-dependent helicase activity
C4J89_RS06545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J89_RS06555	COG0259	pyridoxamine-phosphate oxidase activity
C4J89_RS06565	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J89_RS06585	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4J89_RS06600	COG0583	DNA-binding transcription factor activity
C4J89_RS06615	COG3220	belongs to the UPF0276 family
C4J89_RS06665	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4J89_RS06670	COG2271	Major facilitator Superfamily
C4J89_RS06675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J89_RS06690	COG0306	phosphate transporter
C4J89_RS06700	COG1414	Transcriptional regulator
C4J89_RS06705	COG2814	Major facilitator Superfamily
C4J89_RS06710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J89_RS06715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4J89_RS06720	COG0183	Belongs to the thiolase family
C4J89_RS06725	COG3485	protocatechuate 3,4-dioxygenase
C4J89_RS06730	COG3485	protocatechuate 3,4-dioxygenase
C4J89_RS06735	COG0477	Major facilitator Superfamily
C4J89_RS06745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J89_RS06750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J89_RS06775	COG0443	Heat shock 70 kDa protein
C4J89_RS06790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS06795	COG1309	transcriptional regulator
C4J89_RS06835	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J89_RS06840	COG2197	response regulator
C4J89_RS06845	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS06885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J89_RS06925	COG1454	alcohol dehydrogenase
C4J89_RS06940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J89_RS06945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J89_RS06950	COG2271	Major facilitator Superfamily
C4J89_RS07000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J89_RS07010	COG2267	carboxylic ester hydrolase activity
C4J89_RS07040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J89_RS07090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4J89_RS07120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J89_RS07130	COG0425	Belongs to the sulfur carrier protein TusA family
C4J89_RS07135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4J89_RS07145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J89_RS07150	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4J89_RS07155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J89_RS07160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4J89_RS07200	COG0583	DNA-binding transcription factor activity
C4J89_RS07225	COG2807	transmembrane transport
C4J89_RS07230	COG2910	NAD(P)H-binding
C4J89_RS07240	COG0583	DNA-binding transcription factor activity
C4J89_RS07295	COG3100	YcgL domain-containing protein
C4J89_RS07300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J89_RS07310	COG2983	Belongs to the UPF0260 family
C4J89_RS07350	COG1770	oligopeptidase
C4J89_RS07360	COG0121	glutamine amidotransferase
C4J89_RS07370	COG0583	DNA-binding transcription factor activity
C4J89_RS07375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4J89_RS07380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4J89_RS07385	COG1984	allophanate hydrolase subunit 2
C4J89_RS07395	COG0542	response to heat
C4J89_RS07405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J89_RS07420	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4J89_RS07425	COG0425	Belongs to the sulfur carrier protein TusA family
C4J89_RS07435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J89_RS07440	COG1132	(ABC) transporter
C4J89_RS07445	COG0741	lytic transglycosylase activity
C4J89_RS07450	COG0488	(ABC) transporter
C4J89_RS07455	COG0589	response to stress
C4J89_RS07465	COG1024	Enoyl-CoA hydratase
C4J89_RS07465	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J89_RS07470	COG0183	Belongs to the thiolase family
C4J89_RS07515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J89_RS07520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J89_RS07530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4J89_RS07545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J89_RS07550	COG0584	glycerophosphoryl diester phosphodiesterase
C4J89_RS07560	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J89_RS07565	COG1136	(ABC) transporter
C4J89_RS07570	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J89_RS07590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J89_RS07590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J89_RS07605	COG2853	Lipoprotein
C4J89_RS07620	COG2204	response regulator
C4J89_RS07630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J89_RS07635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J89_RS07765	COG4695	Portal protein
C4J89_RS07775	COG2135	peptidase activity
C4J89_RS07835	COG2814	Major facilitator Superfamily
C4J89_RS07840	COG0579	oxidoreductase
C4J89_RS07845	COG0583	DNA-binding transcription factor activity
C4J89_RS07850	COG0697	spore germination
C4J89_RS07870	COG1611	Belongs to the LOG family
C4J89_RS07880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4J89_RS07900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J89_RS07905	COG0583	DNA-binding transcription factor activity
C4J89_RS07910	COG2814	Major facilitator Superfamily
C4J89_RS07920	COG2233	PERMEase
C4J89_RS07925	COG2267	carboxylic ester hydrolase activity
C4J89_RS07930	COG2197	response regulator
C4J89_RS07935	COG0596	Alpha beta hydrolase
C4J89_RS07945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J89_RS07950	COG0444	Belongs to the ABC transporter superfamily
C4J89_RS07960	COG0747	negative chemotaxis
C4J89_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS07970	COG0546	phosphoglycolate phosphatase activity
C4J89_RS07975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J89_RS07980	COG0402	S-adenosylhomocysteine deaminase activity
C4J89_RS07985	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4J89_RS07995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4J89_RS08005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J89_RS08010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J89_RS08015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4J89_RS08030	COG0776	regulation of translation
C4J89_RS08055	COG1216	Glycosyl transferase, family 2
C4J89_RS08060	COG0438	transferase activity, transferring glycosyl groups
C4J89_RS08090	COG1555	photosystem II stabilization
C4J89_RS08115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J89_RS08125	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J89_RS08130	COG2205	protein histidine kinase activity
C4J89_RS08135	COG0745	RESPONSE REGULATOR receiver
C4J89_RS08170	COG3209	COG3209 Rhs family protein
C4J89_RS08180	COG0084	hydrolase, TatD family'
C4J89_RS08185	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J89_RS08210	COG1131	(ABC) transporter
C4J89_RS08220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J89_RS08225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4J89_RS08230	COG4181	ATPase activity
C4J89_RS08245	COG1376	ErfK ybiS ycfS ynhG family protein
C4J89_RS08275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4J89_RS08295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J89_RS08310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4J89_RS08320	COG1764	response to oxidative stress
C4J89_RS08325	COG1846	Transcriptional regulator
C4J89_RS08330	COG0583	DNA-binding transcription factor activity
C4J89_RS08335	COG0730	response to heat
C4J89_RS08340	COG0583	DNA-binding transcription factor activity
C4J89_RS08350	COG3214	Protein conserved in bacteria
C4J89_RS08355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J89_RS08380	COG3384	dioxygenase
C4J89_RS08385	COG0500	methyltransferase
C4J89_RS08390	COG0501	Belongs to the peptidase M48B family
C4J89_RS08395	COG0436	Aminotransferase
C4J89_RS08400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J89_RS08405	COG0386	Belongs to the glutathione peroxidase family
C4J89_RS08410	COG0784	Response regulator, receiver
C4J89_RS08410	COG2205	protein histidine kinase activity
C4J89_RS08410	COG5002	protein histidine kinase activity
C4J89_RS08420	COG1956	GAF domain-containing protein
C4J89_RS08425	COG2205	protein histidine kinase activity
C4J89_RS08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS08430	COG2197	response regulator
C4J89_RS08460	COG0004	ammonium transporteR
C4J89_RS08475	COG0564	pseudouridine synthase activity
C4J89_RS08485	COG0746	molybdenum cofactor guanylyltransferase activity
C4J89_RS08490	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4J89_RS08495	COG0303	'Molybdopterin
C4J89_RS08505	COG3237	CsbD-like
C4J89_RS08510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J89_RS08520	COG4133	protoheme IX ABC transporter activity
C4J89_RS08540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4J89_RS08545	COG1138	Cytochrome C-type biogenesis protein
C4J89_RS08555	COG3088	subunit of a heme lyase
C4J89_RS08560	COG4235	cytochrome complex assembly
C4J89_RS08575	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4J89_RS08590	COG2814	Major facilitator Superfamily
C4J89_RS08595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J89_RS08600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J89_RS08610	COG0469	pyruvate kinase activity
C4J89_RS08620	COG2084	Dehydrogenase
C4J89_RS08625	COG3622	Belongs to the hyi family
C4J89_RS08630	COG3960	tartronate-semialdehyde synthase activity
C4J89_RS08640	COG1309	transcriptional regulator
C4J89_RS08645	COG2354	Protein conserved in bacteria
C4J89_RS08650	COG2853	Lipoprotein
C4J89_RS08670	COG2113	Glycine betaine
C4J89_RS08675	COG3162	membrane
C4J89_RS08680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J89_RS08690	COG2009	succinate dehydrogenase
C4J89_RS08695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4J89_RS08700	COG1053	succinate dehydrogenase
C4J89_RS08705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J89_RS08720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J89_RS08725	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J89_RS08760	COG0326	Molecular chaperone. Has ATPase activity
C4J89_RS08770	COG1741	Belongs to the pirin family
C4J89_RS08795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J89_RS08800	COG2205	protein histidine kinase activity
C4J89_RS08800	COG0784	Response regulator, receiver
C4J89_RS08800	COG5002	protein histidine kinase activity
C4J89_RS08815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J89_RS08825	COG2062	phosphohistidine phosphatase, SixA
C4J89_RS08850	COG0628	permease
C4J89_RS08865	COG0284	orotidine-5'-phosphate decarboxylase activity
C4J89_RS08870	COG2130	NADP-dependent
C4J89_RS08890	COG2267	carboxylic ester hydrolase activity
C4J89_RS08925	COG3217	Mosc domain protein beta barrel domain protein
C4J89_RS08925	COG0633	Ferredoxin
C4J89_RS08945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J89_RS08965	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS08975	COG0625	glutathione transferase activity
C4J89_RS08980	COG1131	(ABC) transporter
C4J89_RS08985	COG0842	Transport permease protein
C4J89_RS09010	COG2076	Multidrug Resistance protein
C4J89_RS09015	COG0385	Bile acid
C4J89_RS09020	COG2974	May be involved in recombination
C4J89_RS09050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J89_RS09055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J89_RS09080	COG2010	Cytochrome c
C4J89_RS09085	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J89_RS09105	COG2200	EAL domain
C4J89_RS09120	COG3842	ATPase activity
C4J89_RS09155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J89_RS09160	COG1121	(ABC) transporter
C4J89_RS09190	COG1509	lysine 2,3-aminomutase activity
C4J89_RS09195	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J89_RS09225	COG3829	transcription factor binding
C4J89_RS09255	COG5006	permease, DMT superfamily
C4J89_RS09290	COG0768	penicillin binding
C4J89_RS09310	COG0417	DNA replication proofreading
C4J89_RS09330	COG0728	peptidoglycan biosynthetic process
C4J89_RS09370	COG0463	Glycosyl transferase, family 2
C4J89_RS09375	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J89_RS09375	COG0662	Cupin 2, conserved barrel domain protein
C4J89_RS09390	COG4977	sequence-specific DNA binding
C4J89_RS09395	COG0596	Alpha beta hydrolase
C4J89_RS09400	COG3387	PFAM Glycoside hydrolase 15-related
C4J89_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS09425	COG2223	nitrite transmembrane transporter activity
C4J89_RS09430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J89_RS09450	COG3675	Pfam Lipase (class 3)
C4J89_RS09455	COG0402	S-adenosylhomocysteine deaminase activity
C4J89_RS09460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J89_RS09465	COG0720	synthase
C4J89_RS09495	COG0840	transmembrane signaling receptor activity
C4J89_RS09500	COG2056	Na+-H+ antiporter family
C4J89_RS09510	COG0826	peptidase U32
C4J89_RS09515	COG0628	permease
C4J89_RS09530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J89_RS09535	COG3132	Protein of unknown function, DUF480
C4J89_RS09545	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4J89_RS09550	COG0583	DNA-binding transcription factor activity
C4J89_RS09560	COG1253	flavin adenine dinucleotide binding
C4J89_RS09565	COG0709	Synthesizes selenophosphate from selenide and ATP
C4J89_RS09570	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4J89_RS09575	COG0701	Predicted permease
C4J89_RS09585	COG0625	glutathione transferase activity
C4J89_RS09590	COG0384	phenazine biosynthesis protein PhzF
C4J89_RS09595	COG0113	porphobilinogen synthase activity
C4J89_RS09615	COG3209	COG3209 Rhs family protein
C4J89_RS09635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J89_RS09640	COG0583	DNA-binding transcription factor activity
C4J89_RS09650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4J89_RS09655	COG0517	IMP dehydrogenase activity
C4J89_RS09660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J89_RS09665	COG0477	Major facilitator Superfamily
C4J89_RS09680	COG0174	glutamine synthetase
C4J89_RS09695	COG2814	Major facilitator Superfamily
C4J89_RS09725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J89_RS09735	COG2197	response regulator
C4J89_RS09740	COG2205	protein histidine kinase activity
C4J89_RS09740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS09750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4J89_RS09755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J89_RS09770	COG2197	response regulator
C4J89_RS09775	COG0322	excinuclease ABC activity
C4J89_RS09790	COG0582	viral genome integration into host DNA
C4J89_RS09960	COG0402	S-adenosylhomocysteine deaminase activity
C4J89_RS10035	COG1132	(ABC) transporter
C4J89_RS10120	COG2003	Belongs to the UPF0758 family
C4J89_RS10140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J89_RS10195	COG3038	cytochrome b561
C4J89_RS10200	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS10215	COG0840	transmembrane signaling receptor activity
C4J89_RS10245	COG0028	Belongs to the TPP enzyme family
C4J89_RS10250	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS10275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J89_RS10285	COG2207	Transcriptional regulator
C4J89_RS10305	COG5002	protein histidine kinase activity
C4J89_RS10310	COG0745	RESPONSE REGULATOR receiver
C4J89_RS10330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS10340	COG2814	Major facilitator Superfamily
C4J89_RS10365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J89_RS10380	COG1414	Transcriptional regulator
C4J89_RS10400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J89_RS10455	COG2207	Transcriptional regulator
C4J89_RS10495	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J89_RS10545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J89_RS10550	COG3710	Transcriptional regulator
C4J89_RS10550	COG0457	Tetratricopeptide repeat
C4J89_RS10595	COG2197	response regulator
C4J89_RS10605	COG2197	response regulator
C4J89_RS10630	COG3121	Chaperone
C4J89_RS10635	COG3188	usher protein
C4J89_RS10655	COG3121	Chaperone
C4J89_RS10660	COG3188	usher protein
C4J89_RS10680	COG0531	amino acid
C4J89_RS10705	COG2201	protein-glutamate methylesterase activity
C4J89_RS10710	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4J89_RS10720	COG0835	chemotaxis
C4J89_RS10730	COG0643	Histidine kinase
C4J89_RS10730	COG2198	Histidine kinase
C4J89_RS10740	COG0745	RESPONSE REGULATOR receiver
C4J89_RS10770	COG2814	Major facilitator Superfamily
C4J89_RS10780	COG0583	DNA-binding transcription factor activity
C4J89_RS10795	COG0583	DNA-binding transcription factor activity
C4J89_RS10805	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS10820	COG3546	catalase activity
C4J89_RS10825	COG3685	Protein conserved in bacteria
C4J89_RS10830	COG4191	Histidine kinase
C4J89_RS10830	COG0784	Response regulator, receiver
C4J89_RS10835	COG0109	protoheme IX farnesyltransferase activity
C4J89_RS10845	COG1845	cytochrome c oxidase, subunit III
C4J89_RS10855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J89_RS10900	COG3729	General stress protein
C4J89_RS10905	COG2203	Gaf domain
C4J89_RS10905	COG5001	Diguanylate cyclase
C4J89_RS10905	COG3706	GGDEF domain
C4J89_RS10905	COG4251	negative regulation of phosphorylation
C4J89_RS10925	COG2323	membrane
C4J89_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS10965	COG1546	Belongs to the CinA family
C4J89_RS10990	COG2080	2 iron, 2 sulfur cluster binding
C4J89_RS10995	COG0583	DNA-binding transcription factor activity
C4J89_RS11005	COG4948	Mandelate Racemase Muconate Lactonizing
C4J89_RS11025	COG0019	diaminopimelate decarboxylase activity
C4J89_RS11030	COG1609	Transcriptional regulator
C4J89_RS11045	COG1177	transmembrane transport
C4J89_RS11050	COG3842	ATPase activity
C4J89_RS11055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J89_RS11060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4J89_RS11065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J89_RS11085	COG2194	sulfuric ester hydrolase activity
C4J89_RS11090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J89_RS11095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4J89_RS11100	COG0561	phosphatase activity
C4J89_RS11110	COG2204	response regulator
C4J89_RS11170	COG0583	DNA-binding transcription factor activity
C4J89_RS11190	COG2233	PERMEase
C4J89_RS11210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J89_RS11220	COG1609	Transcriptional regulator
C4J89_RS11260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS11265	COG0745	RESPONSE REGULATOR receiver
C4J89_RS11270	COG2205	protein histidine kinase activity
C4J89_RS11280	COG0730	response to heat
C4J89_RS11290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J89_RS11295	COG0024	Methionine aminopeptidase
C4J89_RS11315	COG1070	Carbohydrate kinase
C4J89_RS11335	COG1175	transmembrane transport
C4J89_RS11385	COG1538	Outer membrane efflux protein
C4J89_RS11390	COG4214	carbohydrate transport
C4J89_RS11395	COG1129	ABC transporter
C4J89_RS11400	COG4213	ABC transporter substrate-binding protein
C4J89_RS11410	COG2115	Belongs to the xylose isomerase family
C4J89_RS11415	COG1609	Transcriptional regulator
C4J89_RS11415	COG2207	Transcriptional regulator
C4J89_RS11430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J89_RS11440	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J89_RS11445	COG3842	ATPase activity
C4J89_RS11455	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J89_RS11460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4J89_RS11465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J89_RS11475	COG0477	Major facilitator Superfamily
C4J89_RS11485	COG2186	Transcriptional regulator
C4J89_RS11490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J89_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS11505	COG2267	carboxylic ester hydrolase activity
C4J89_RS11520	COG3781	membrane
C4J89_RS11535	COG0640	Transcriptional regulator
C4J89_RS11540	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS11550	COG1609	Transcriptional regulator
C4J89_RS11570	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS11580	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS11585	COG1129	ABC transporter
C4J89_RS11590	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS11605	COG2207	Transcriptional regulator
C4J89_RS11615	COG0625	glutathione transferase activity
C4J89_RS11630	COG0673	inositol 2-dehydrogenase activity
C4J89_RS11665	COG1968	undecaprenyl-diphosphatase activity
C4J89_RS11680	COG1309	transcriptional regulator
C4J89_RS11690	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS11695	COG0604	alcohol dehydrogenase
C4J89_RS11695	COG3321	synthase
C4J89_RS11705	COG0583	DNA-binding transcription factor activity
C4J89_RS11730	COG1064	alcohol dehydrogenase
C4J89_RS11765	COG0318	PFAM AMP-dependent synthetase and ligase
C4J89_RS11795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J89_RS11795	COG0475	glutathione-regulated potassium exporter activity
C4J89_RS11800	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C4J89_RS11805	COG1396	sequence-specific DNA binding
C4J89_RS11880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J89_RS11890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS11905	COG1177	transmembrane transport
C4J89_RS11910	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J89_RS11915	COG3842	ATPase activity
C4J89_RS11920	COG1414	Transcriptional regulator
C4J89_RS11930	COG0534	Mate efflux family protein
C4J89_RS12015	COG1741	Belongs to the pirin family
C4J89_RS12035	COG1917	Cupin 2, conserved barrel domain protein
C4J89_RS12035	COG4977	sequence-specific DNA binding
C4J89_RS12050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4J89_RS12055	COG1335	isochorismatase
C4J89_RS12060	COG0583	DNA-binding transcription factor activity
C4J89_RS12070	COG5001	Diguanylate cyclase
C4J89_RS12070	COG3447	MASE1 domain protein
C4J89_RS12070	COG5002	protein histidine kinase activity
C4J89_RS12080	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C4J89_RS12100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J89_RS12105	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS12110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J89_RS12120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J89_RS12130	COG0583	DNA-binding transcription factor activity
C4J89_RS12175	COG5383	Protein conserved in bacteria
C4J89_RS12195	COG0616	signal peptide processing
C4J89_RS12200	COG1461	Dihydroxyacetone kinase
C4J89_RS12205	COG2376	Dihydroxyacetone kinase
C4J89_RS12210	COG1063	alcohol dehydrogenase
C4J89_RS12215	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS12220	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS12225	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS12230	COG1129	ABC transporter
C4J89_RS12235	COG0698	ribose 5-phosphate isomerase
C4J89_RS12245	COG1253	flavin adenine dinucleotide binding
C4J89_RS12270	COG0765	amino acid transport
C4J89_RS12275	COG0765	amino acid transport
C4J89_RS12305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J89_RS12315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J89_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS12325	COG2610	gluconate transmembrane transporter activity
C4J89_RS12330	COG3829	transcription factor binding
C4J89_RS12330	COG3290	protein histidine kinase activity
C4J89_RS12335	COG4172	Belongs to the ABC transporter superfamily
C4J89_RS12340	COG4239	(ABC) transporter, permease
C4J89_RS12345	COG4174	ABC transporter (Permease)
C4J89_RS12350	COG4166	transmembrane transport
C4J89_RS12355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J89_RS12365	COG0656	L-ascorbic acid biosynthetic process
C4J89_RS12410	COG2204	response regulator
C4J89_RS12450	COG0515	serine threonine protein kinase
C4J89_RS12465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4J89_RS12490	COG3239	Fatty acid desaturase
C4J89_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS12525	COG0183	Belongs to the thiolase family
C4J89_RS12530	COG0318	PFAM AMP-dependent synthetase and ligase
C4J89_RS12535	COG0673	inositol 2-dehydrogenase activity
C4J89_RS12575	COG2706	6-phosphogluconolactonase activity
C4J89_RS12595	COG0420	3'-5' exonuclease activity
C4J89_RS12630	COG0714	Associated with various cellular activities
C4J89_RS12645	COG2186	Transcriptional regulator
C4J89_RS12660	COG0519	Catalyzes the synthesis of GMP from XMP
C4J89_RS12670	COG0625	glutathione transferase activity
C4J89_RS12705	COG2205	protein histidine kinase activity
C4J89_RS12710	COG0745	RESPONSE REGULATOR receiver
C4J89_RS12730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J89_RS12740	COG3718	enzyme involved in inositol metabolism
C4J89_RS12755	COG0673	inositol 2-dehydrogenase activity
C4J89_RS12760	COG0673	inositol 2-dehydrogenase activity
C4J89_RS12770	COG1129	ABC transporter
C4J89_RS12775	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS12835	COG0673	inositol 2-dehydrogenase activity
C4J89_RS12855	COG4172	Belongs to the ABC transporter superfamily
C4J89_RS12860	COG4239	(ABC) transporter, permease
C4J89_RS12865	COG4174	ABC transporter (Permease)
C4J89_RS12870	COG4166	transmembrane transport
C4J89_RS12875	COG4166	transmembrane transport
C4J89_RS12880	COG0741	lytic transglycosylase activity
C4J89_RS12880	COG1388	LysM domain
C4J89_RS12885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J89_RS12895	COG0328	RNA-DNA hybrid ribonuclease activity
C4J89_RS12900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J89_RS12910	COG0840	transmembrane signaling receptor activity
C4J89_RS12915	COG1968	undecaprenyl-diphosphatase activity
C4J89_RS12935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J89_RS12950	COG0488	(ABC) transporter
C4J89_RS12980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4J89_RS12990	COG2133	pyrroloquinoline quinone binding
C4J89_RS13005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J89_RS13010	COG2822	iron ion transport
C4J89_RS13020	COG2822	iron ion transport
C4J89_RS13025	COG0672	)-iron permease
C4J89_RS13030	COG2207	Transcriptional regulator
C4J89_RS13065	COG2204	response regulator
C4J89_RS13070	COG0784	Response regulator, receiver
C4J89_RS13070	COG2205	protein histidine kinase activity
C4J89_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS13205	COG2315	Protein conserved in bacteria
C4J89_RS13210	COG2207	Transcriptional regulator
C4J89_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS13245	COG1280	lysine exporter protein (LysE YggA)
C4J89_RS13255	COG0563	adenylate kinase activity
C4J89_RS13265	COG1335	isochorismatase
C4J89_RS13270	COG0640	Transcriptional regulator
C4J89_RS13285	COG1132	(ABC) transporter
C4J89_RS13305	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS13315	COG0583	DNA-binding transcription factor activity
C4J89_RS13365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J89_RS13375	COG0747	negative chemotaxis
C4J89_RS13390	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS13405	COG0529	Catalyzes the synthesis of activated sulfate
C4J89_RS13415	COG3320	Male sterility
C4J89_RS13415	COG1022	Amp-dependent synthetase and ligase
C4J89_RS13420	COG0697	spore germination
C4J89_RS13425	COG0583	DNA-binding transcription factor activity
C4J89_RS13435	COG4948	Mandelate Racemase Muconate Lactonizing
C4J89_RS13455	COG2223	nitrite transmembrane transporter activity
C4J89_RS13460	COG4638	Rieske (2fe-2S)
C4J89_RS13470	COG0583	DNA-binding transcription factor activity
C4J89_RS13475	COG4175	Glycine betaine
C4J89_RS13480	COG4176	ABC-type proline glycine betaine transport system permease component
C4J89_RS13485	COG2113	Glycine betaine
C4J89_RS13510	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS13520	COG3321	synthase
C4J89_RS13520	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS13520	COG0604	alcohol dehydrogenase
C4J89_RS13595	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J89_RS13610	COG0513	Belongs to the DEAD box helicase family
C4J89_RS13620	COG2308	Evidence 4 Homologs of previously reported genes of
C4J89_RS13645	COG0784	Response regulator, receiver
C4J89_RS13650	COG2202	Pas domain
C4J89_RS13650	COG2205	protein histidine kinase activity
C4J89_RS13665	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS13670	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS13675	COG1609	Transcriptional regulator
C4J89_RS13680	COG1070	Carbohydrate kinase
C4J89_RS13685	COG1522	sequence-specific DNA binding
C4J89_RS13695	COG0826	peptidase U32
C4J89_RS13705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J89_RS13715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J89_RS13730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J89_RS13750	COG0596	Alpha beta hydrolase
C4J89_RS13755	COG0596	Alpha beta hydrolase
C4J89_RS13820	COG3920	Histidine kinase
C4J89_RS13820	COG2202	Pas domain
C4J89_RS13860	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J89_RS13885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4J89_RS13890	COG1349	DNA-binding transcription factor activity
C4J89_RS13900	COG0738	Major facilitator superfamily
C4J89_RS13915	COG2814	Major facilitator Superfamily
C4J89_RS13920	COG4974	Belongs to the 'phage' integrase family
C4J89_RS13930	COG0463	Glycosyl transferase, family 2
C4J89_RS13935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J89_RS13935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J89_RS13940	COG0726	polysaccharide deacetylase
C4J89_RS13945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J89_RS13950	COG2076	Multidrug Resistance protein
C4J89_RS13955	COG2076	Multidrug Resistance protein
C4J89_RS13980	COG1024	Enoyl-CoA hydratase
C4J89_RS13985	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS13990	COG1024	Enoyl-CoA hydratase
C4J89_RS13995	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS14010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J89_RS14020	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J89_RS14035	COG5002	protein histidine kinase activity
C4J89_RS14035	COG0784	Response regulator, receiver
C4J89_RS14035	COG2205	protein histidine kinase activity
C4J89_RS14045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J89_RS14050	COG2205	protein histidine kinase activity
C4J89_RS14050	COG0784	Response regulator, receiver
C4J89_RS14050	COG2198	Histidine kinase
C4J89_RS14075	COG1794	racemase activity, acting on amino acids and derivatives
C4J89_RS14080	COG1247	-acetyltransferase
C4J89_RS14090	COG1929	Belongs to the glycerate kinase type-1 family
C4J89_RS14095	COG3835	regulator
C4J89_RS14100	COG2271	Major facilitator Superfamily
C4J89_RS14105	COG0667	Aldo Keto reductase
C4J89_RS14125	COG0583	DNA-binding transcription factor activity
C4J89_RS14130	COG2200	EAL domain
C4J89_RS14195	COG3258	Cytochrome c
C4J89_RS14200	COG2863	cytochrome
C4J89_RS14215	COG3145	DNA-N1-methyladenine dioxygenase activity
C4J89_RS14235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4J89_RS14245	COG0488	(ABC) transporter
C4J89_RS14265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4J89_RS14350	COG0531	amino acid
C4J89_RS14355	COG3938	Belongs to the proline racemase family
C4J89_RS14375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS14380	COG1397	ADP-ribosylglycohydrolase
C4J89_RS14405	COG3663	DNA glycosylase
C4J89_RS14420	COG2366	antibiotic biosynthetic process
C4J89_RS14435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J89_RS14440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J89_RS14445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J89_RS14445	COG1116	anion transmembrane transporter activity
C4J89_RS14465	COG0583	DNA-binding transcription factor activity
C4J89_RS14470	COG0667	Aldo Keto reductase
C4J89_RS14475	COG0840	transmembrane signaling receptor activity
C4J89_RS14485	COG0596	Alpha beta hydrolase
C4J89_RS14490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J89_RS14495	COG0297	glycogen (starch) synthase activity
C4J89_RS14500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J89_RS14505	COG1640	4-alpha-glucanotransferase
C4J89_RS14555	COG0840	transmembrane signaling receptor activity
C4J89_RS14565	COG5002	protein histidine kinase activity
C4J89_RS14625	COG2814	Major facilitator Superfamily
C4J89_RS14640	COG0626	cystathionine gamma-synthase activity
C4J89_RS14645	COG1944	ATP diphosphatase activity
C4J89_RS14650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J89_RS14650	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J89_RS14680	COG2271	Major facilitator Superfamily
C4J89_RS14685	COG0519	Catalyzes the synthesis of GMP from XMP
C4J89_RS14700	COG2207	Transcriptional regulator
C4J89_RS14715	COG2207	Transcriptional regulator
C4J89_RS14720	COG2223	nitrite transmembrane transporter activity
C4J89_RS14730	COG0154	amidase activity
C4J89_RS14740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J89_RS14745	COG0697	spore germination
C4J89_RS14770	COG2205	protein histidine kinase activity
C4J89_RS14775	COG0745	RESPONSE REGULATOR receiver
C4J89_RS14790	COG0589	response to stress
C4J89_RS14805	COG0814	amino acid
C4J89_RS14810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J89_RS14820	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS14835	COG0308	aminopeptidase N
C4J89_RS14845	COG3139	Protein of unknown function (DUF1315)
C4J89_RS14855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J89_RS14860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4J89_RS14910	COG0316	Belongs to the HesB IscA family
C4J89_RS14910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4J89_RS14915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4J89_RS14955	COG0028	Belongs to the TPP enzyme family
C4J89_RS14960	COG0431	NADPH-dependent FMN reductase
C4J89_RS14980	COG0456	acetyltransferase
C4J89_RS15000	COG0708	Exodeoxyribonuclease III
C4J89_RS15020	COG1126	abc transporter atp-binding protein
C4J89_RS15030	COG0765	amino acid transport
C4J89_RS15035	COG0436	Aminotransferase
C4J89_RS15040	COG0277	FAD linked oxidase domain protein
C4J89_RS15055	COG0583	DNA-binding transcription factor activity
C4J89_RS15060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4J89_RS15080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J89_RS15085	COG1116	anion transmembrane transporter activity
C4J89_RS15090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J89_RS15115	COG2816	NAD+ diphosphatase activity
C4J89_RS15120	COG1024	Enoyl-CoA hydratase
C4J89_RS15125	COG3318	Belongs to the UPF0149 family
C4J89_RS15125	COG3012	SEC-C Motif Domain Protein
C4J89_RS15130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J89_RS15140	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J89_RS15160	COG0784	Response regulator, receiver
C4J89_RS15160	COG4191	Histidine kinase
C4J89_RS15165	COG3706	GGDEF domain
C4J89_RS15170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J89_RS15175	COG0366	Alpha amylase catalytic
C4J89_RS15185	COG1285	pathogenesis
C4J89_RS15195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J89_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS15205	COG2066	Belongs to the glutaminase family
C4J89_RS15230	COG0784	Response regulator, receiver
C4J89_RS15230	COG4191	Histidine kinase
C4J89_RS15235	COG0587	DNA-directed DNA polymerase activity
C4J89_RS15250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4J89_RS15260	COG0494	nUDIX hydrolase
C4J89_RS15270	COG1304	FMN binding
C4J89_RS15295	COG0693	protein deglycase activity
C4J89_RS15310	COG1999	signal sequence binding
C4J89_RS15330	COG2072	flavoprotein involved in K transport
C4J89_RS15350	COG0583	DNA-binding transcription factor activity
C4J89_RS15355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J89_RS15370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4J89_RS15375	COG0596	Alpha beta hydrolase
C4J89_RS15385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J89_RS15390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J89_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS15410	COG0583	DNA-binding transcription factor activity
C4J89_RS15420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J89_RS15435	COG2814	Major facilitator Superfamily
C4J89_RS15440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS15445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J89_RS15450	COG3209	COG3209 Rhs family protein
C4J89_RS15490	COG3706	GGDEF domain
C4J89_RS15495	COG1280	lysine exporter protein (LysE YggA)
C4J89_RS15510	COG2186	Transcriptional regulator
C4J89_RS15515	COG1522	sequence-specific DNA binding
C4J89_RS15525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J89_RS15530	COG2814	Major facilitator Superfamily
C4J89_RS15540	COG2207	Transcriptional regulator
C4J89_RS15550	COG1063	alcohol dehydrogenase
C4J89_RS15555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4J89_RS15580	COG0395	ABC-type sugar transport system, permease component
C4J89_RS15590	COG3842	ATPase activity
C4J89_RS15595	COG3842	ATPase activity
C4J89_RS15600	COG3284	Transcriptional regulator
C4J89_RS15670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4J89_RS15675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4J89_RS15680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4J89_RS15685	COG2835	tetraacyldisaccharide 4'-kinase activity
C4J89_RS15690	COG1663	tetraacyldisaccharide 4'-kinase activity
C4J89_RS15695	COG0848	biopolymer transport protein
C4J89_RS15700	COG0811	peptide transport
C4J89_RS15705	COG2333	competence protein COMEC
C4J89_RS15705	COG0658	competence protein
C4J89_RS15725	COG0784	Response regulator, receiver
C4J89_RS15725	COG2205	protein histidine kinase activity
C4J89_RS15725	COG5002	protein histidine kinase activity
C4J89_RS15730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J89_RS15750	COG1393	Belongs to the ArsC family
C4J89_RS15765	COG2818	Glycosylase
C4J89_RS15770	COG0037	tRNA processing
C4J89_RS15780	COG3091	SprT-like family
C4J89_RS15785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J89_RS15805	COG2920	part of a sulfur-relay system
C4J89_RS15815	COG0435	Glutathione S-transferase
C4J89_RS15820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J89_RS15820	COG1648	precorrin-2 dehydrogenase activity
C4J89_RS15825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4J89_RS15830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J89_RS15835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4J89_RS15840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4J89_RS15845	COG1674	ftsk spoiiie
C4J89_RS15850	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4J89_RS15855	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4J89_RS15860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4J89_RS15865	COG0542	response to heat
C4J89_RS15870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4J89_RS15875	COG1278	Cold shock
C4J89_RS15890	COG0583	DNA-binding transcription factor activity
C4J89_RS15900	COG4670	ketone body catabolic process
C4J89_RS15910	COG0697	spore germination
C4J89_RS15920	COG0482	sulfurtransferase activity
C4J89_RS15925	COG2915	High frequency lysogenization protein hflD homolog
C4J89_RS15935	COG2850	peptidyl-arginine hydroxylation
C4J89_RS15940	COG2153	protein acetylation
C4J89_RS15950	COG2224	Isocitrate lyase
C4J89_RS15960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J89_RS15965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J89_RS15970	COG0649	NAD binding
C4J89_RS15970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J89_RS15985	COG1034	ATP synthesis coupled electron transport
C4J89_RS15990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J89_RS15995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J89_RS16005	COG0713	ATP synthesis coupled electron transport
C4J89_RS16020	COG1007	ATP synthesis coupled electron transport
C4J89_RS16025	COG2944	sequence-specific DNA binding
C4J89_RS16055	COG2814	Major facilitator Superfamily
C4J89_RS16080	COG1136	(ABC) transporter
C4J89_RS16080	COG0577	efflux transmembrane transporter activity
C4J89_RS16085	COG1136	(ABC) transporter
C4J89_RS16085	COG0577	efflux transmembrane transporter activity
C4J89_RS16095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS16160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J89_RS16160	COG2111	Na H antiporter
C4J89_RS16165	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J89_RS16170	COG0651	ATP synthesis coupled electron transport
C4J89_RS16180	COG2212	antiporter activity
C4J89_RS16185	COG1320	monovalent cation:proton antiporter activity
C4J89_RS16210	COG0215	cysteine-tRNA ligase activity
C4J89_RS16215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J89_RS16225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J89_RS16230	COG2814	Major facilitator Superfamily
C4J89_RS16235	COG1566	PFAM secretion protein HlyD family protein
C4J89_RS16245	COG1846	Transcriptional regulator
C4J89_RS16250	COG2911	Protein conserved in bacteria
C4J89_RS16255	COG0729	surface antigen
C4J89_RS16265	COG0708	Exodeoxyribonuclease III
C4J89_RS16270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4J89_RS16275	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS16285	COG0789	Transcriptional regulator
C4J89_RS16295	COG0318	PFAM AMP-dependent synthetase and ligase
C4J89_RS16300	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS16305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J89_RS16330	COG2866	Carboxypeptidase
C4J89_RS16335	COG3038	cytochrome b561
C4J89_RS16365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J89_RS16375	COG0217	transcriptional regulatory protein
C4J89_RS16380	COG0583	DNA-binding transcription factor activity
C4J89_RS16385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J89_RS16390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J89_RS16395	COG3038	cytochrome b561
C4J89_RS16405	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS16405	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J89_RS16420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J89_RS16425	COG1846	Transcriptional regulator
C4J89_RS16430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J89_RS16440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J89_RS16460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J89_RS16465	COG0776	regulation of translation
C4J89_RS16470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J89_RS16475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4J89_RS16480	COG0740	serine-type endopeptidase activity
C4J89_RS16485	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4J89_RS16510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4J89_RS16540	COG1686	Belongs to the peptidase S11 family
C4J89_RS16580	COG1953	Uracil, thiamine, allantoin
C4J89_RS16590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J89_RS16590	COG0493	'glutamate synthase
C4J89_RS16600	COG1309	transcriptional regulator
C4J89_RS16605	COG2372	response to copper ion
C4J89_RS16620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J89_RS16630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4J89_RS16670	COG0640	Transcriptional regulator
C4J89_RS16680	COG1522	sequence-specific DNA binding
C4J89_RS16685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J89_RS16690	COG0022	dehydrogenase e1 component
C4J89_RS16700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J89_RS16705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J89_RS16735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J89_RS16740	COG1136	(ABC) transporter
C4J89_RS16740	COG0577	efflux transmembrane transporter activity
C4J89_RS16755	COG2186	Transcriptional regulator
C4J89_RS16800	COG1609	Transcriptional regulator
C4J89_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS16810	COG1070	Carbohydrate kinase
C4J89_RS16815	COG1063	alcohol dehydrogenase
C4J89_RS16820	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS16830	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS16850	COG1136	(ABC) transporter
C4J89_RS16860	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J89_RS16865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J89_RS16890	COG0583	DNA-binding transcription factor activity
C4J89_RS16895	COG0583	DNA-binding transcription factor activity
C4J89_RS16900	COG0625	glutathione transferase activity
C4J89_RS16930	COG0667	Aldo Keto reductase
C4J89_RS16970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS16975	COG1126	abc transporter atp-binding protein
C4J89_RS16990	COG1450	Type ii and iii secretion system protein
C4J89_RS17005	COG3166	PFAM Fimbrial assembly family protein
C4J89_RS17010	COG3156	type II secretion system protein K
C4J89_RS17025	COG2165	general secretion pathway protein
C4J89_RS17030	COG2165	general secretion pathway protein
C4J89_RS17035	COG1459	type II secretion system
C4J89_RS17040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J89_RS17080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J89_RS17085	COG1301	dicarboxylic acid transport
C4J89_RS17090	COG4948	Mandelate Racemase Muconate Lactonizing
C4J89_RS17095	COG0583	DNA-binding transcription factor activity
C4J89_RS17140	COG0776	regulation of translation
C4J89_RS17145	COG0072	phenylalanine-tRNA ligase activity
C4J89_RS17150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J89_RS17155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4J89_RS17160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4J89_RS17165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4J89_RS17170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J89_RS17180	COG1278	Cold shock
C4J89_RS17205	COG1869	D-ribose catabolic process
C4J89_RS17210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J89_RS17215	COG1609	Transcriptional regulator
C4J89_RS17220	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS17225	COG1129	ABC transporter
C4J89_RS17230	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS17255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J89_RS17265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J89_RS17280	COG5002	protein histidine kinase activity
C4J89_RS17310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS17345	COG1286	toxin biosynthetic process
C4J89_RS17350	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J89_RS17355	COG0285	dihydrofolate synthase activity
C4J89_RS17360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4J89_RS17365	COG0135	phosphoribosylanthranilate isomerase activity
C4J89_RS17390	COG0473	3-isopropylmalate dehydrogenase activity
C4J89_RS17395	COG2226	methyltransferase
C4J89_RS17400	COG0066	3-isopropylmalate dehydratase activity
C4J89_RS17405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J89_RS17430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J89_RS17440	COG0596	Alpha beta hydrolase
C4J89_RS17470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J89_RS17475	COG0556	nucleotide-excision repair
C4J89_RS17490	COG0583	DNA-binding transcription factor activity
C4J89_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS17515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J89_RS17520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J89_RS17525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J89_RS17540	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4J89_RS17570	COG0251	oxidation-reduction process
C4J89_RS17610	COG3011	Protein conserved in bacteria
C4J89_RS17625	COG0477	Major facilitator Superfamily
C4J89_RS17660	COG0840	transmembrane signaling receptor activity
C4J89_RS17665	COG2384	SAM-dependent methyltransferase
C4J89_RS17670	COG2186	Transcriptional regulator
C4J89_RS17690	COG3657	addiction module killer protein
C4J89_RS17695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J89_RS17715	COG2391	methyltransferase activity
C4J89_RS17725	COG0583	DNA-binding transcription factor activity
C4J89_RS17730	COG1304	FMN binding
C4J89_RS17745	COG5001	Diguanylate cyclase
C4J89_RS17745	COG5002	protein histidine kinase activity
C4J89_RS17760	COG1054	Belongs to the UPF0176 family
C4J89_RS17790	COG0271	Belongs to the BolA IbaG family
C4J89_RS17800	COG0114	fumarate hydratase activity
C4J89_RS17815	COG0697	spore germination
C4J89_RS17825	COG3539	Fimbrial protein
C4J89_RS17830	COG3539	Fimbrial protein
C4J89_RS17835	COG3539	Fimbrial protein
C4J89_RS17845	COG3121	Chaperone
C4J89_RS17850	COG3188	usher protein
C4J89_RS17870	COG0583	DNA-binding transcription factor activity
C4J89_RS17875	COG0183	Belongs to the thiolase family
C4J89_RS17880	COG2326	polyphosphate kinase activity
C4J89_RS17885	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4J89_RS17885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS17890	COG0367	asparagine synthase
C4J89_RS17895	COG0189	ligase activity
C4J89_RS17895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J89_RS17905	COG1363	Peptidase, m42
C4J89_RS17910	COG3089	Belongs to the UPF0270 family
C4J89_RS17915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J89_RS17930	COG1368	sulfuric ester hydrolase activity
C4J89_RS17955	COG2197	response regulator
C4J89_RS17960	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4J89_RS17970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4J89_RS17975	COG1073	alpha beta
C4J89_RS18000	COG2840	Smr protein MutS2
C4J89_RS18005	COG0302	gtp cyclohydrolase
C4J89_RS18025	COG2851	Citrate transporter
C4J89_RS18030	COG0583	DNA-binding transcription factor activity
C4J89_RS18040	COG0625	glutathione transferase activity
C4J89_RS18045	COG2252	PERMEase
C4J89_RS18075	COG4266	Belongs to the allantoicase family
C4J89_RS18080	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4J89_RS18090	COG2233	PERMEase
C4J89_RS18105	COG1560	Kdo2-lipid A biosynthetic process
C4J89_RS18110	COG0850	regulation of cytokinetic process
C4J89_RS18115	COG2894	cell division
C4J89_RS18120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4J89_RS18125	COG0564	pseudouridine synthase activity
C4J89_RS18130	COG1362	aminopeptidase activity
C4J89_RS18135	COG0668	transmembrane transport
C4J89_RS18170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J89_RS18235	COG3123	guanosine phosphorylase activity
C4J89_RS18240	COG0633	Ferredoxin
C4J89_RS18240	COG3217	Mosc domain protein beta barrel domain protein
C4J89_RS18255	COG3851	Histidine kinase
C4J89_RS18260	COG2197	response regulator
C4J89_RS18265	COG1597	lipid kinase activity
C4J89_RS18290	COG1192	Involved in chromosome partitioning
C4J89_RS18295	COG1360	Flagellar Motor Protein
C4J89_RS18300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4J89_RS18305	COG2201	protein-glutamate methylesterase activity
C4J89_RS18310	COG0643	Histidine kinase
C4J89_RS18310	COG0784	Response regulator, receiver
C4J89_RS18310	COG2198	Histidine kinase
C4J89_RS18315	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4J89_RS18440	COG1677	Flagellar hook-basal body complex protein FliE
C4J89_RS18470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4J89_RS18485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J89_RS18505	COG1706	bacterial-type flagellum-dependent cell motility
C4J89_RS18510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4J89_RS18520	COG4787	bacterial-type flagellum-dependent cell motility
C4J89_RS18535	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4J89_RS18550	COG2207	Transcriptional regulator
C4J89_RS18565	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4J89_RS18570	COG1846	Transcriptional regulator
C4J89_RS18575	COG0514	ATP-dependent DNA helicase (RecQ)
C4J89_RS18585	COG2832	Protein of unknown function (DUF454)
C4J89_RS18590	COG2205	protein histidine kinase activity
C4J89_RS18590	COG2198	Histidine kinase
C4J89_RS18590	COG0784	Response regulator, receiver
C4J89_RS18640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4J89_RS18645	COG0406	alpha-ribazole phosphatase activity
C4J89_RS18650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J89_RS18660	COG1492	cobalamin metabolic process
C4J89_RS18670	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4J89_RS18675	COG0778	Nitroreductase
C4J89_RS18680	COG1797	cobyrinic acid a,c-diamide synthase activity
C4J89_RS18695	COG0791	NLP P60 protein
C4J89_RS18700	COG0791	NLP P60 protein
C4J89_RS18705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J89_RS18710	COG0628	permease
C4J89_RS18720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4J89_RS18725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4J89_RS18740	COG4264	IucA IucC family
C4J89_RS18745	COG2814	Major facilitator Superfamily
C4J89_RS18755	COG3122	Protein conserved in bacteria
C4J89_RS18760	COG3956	TIGRFAM MazG family protein
C4J89_RS18765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J89_RS18770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J89_RS18815	COG0583	DNA-binding transcription factor activity
C4J89_RS18825	COG1953	Uracil, thiamine, allantoin
C4J89_RS18835	COG2996	Protein conserved in bacteria
C4J89_RS18865	COG0513	Belongs to the DEAD box helicase family
C4J89_RS18870	COG2226	methyltransferase
C4J89_RS18900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J89_RS18925	COG1132	(ABC) transporter
C4J89_RS18935	COG2188	Transcriptional regulator
C4J89_RS18945	COG1595	DNA-templated transcription, initiation
C4J89_RS18955	COG1643	Atp-dependent helicase
C4J89_RS18970	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4J89_RS18990	COG0840	transmembrane signaling receptor activity
C4J89_RS19000	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J89_RS19015	COG2010	Cytochrome c
C4J89_RS19020	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J89_RS19035	COG2010	Cytochrome c
C4J89_RS19050	COG0348	domain, Protein
C4J89_RS19060	COG2217	Heavy metal translocating P-type atpase
C4J89_RS19085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J89_RS19090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J89_RS19095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4J89_RS19100	COG2130	NADP-dependent
C4J89_RS19105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4J89_RS19110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4J89_RS19140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J89_RS19145	COG3115	cell septum assembly
C4J89_RS19165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J89_RS19175	COG0402	S-adenosylhomocysteine deaminase activity
C4J89_RS19180	COG1802	Transcriptional regulator
C4J89_RS19185	COG3135	benzoate transporter
C4J89_RS19190	COG3171	Protein conserved in bacteria
C4J89_RS19205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J89_RS19205	COG0116	Belongs to the methyltransferase superfamily
C4J89_RS19210	COG3130	regulation of translation
C4J89_RS19215	COG0167	dihydroorotate dehydrogenase activity
C4J89_RS19230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J89_RS19240	COG1116	anion transmembrane transporter activity
C4J89_RS19240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J89_RS19245	COG3707	response regulator
C4J89_RS19250	COG2223	nitrite transmembrane transporter activity
C4J89_RS19260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J89_RS19265	COG2146	nitrite reductase [NAD(P)H] activity
C4J89_RS19270	COG0243	molybdopterin cofactor binding
C4J89_RS19275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J89_RS19280	COG3047	cAMP biosynthetic process
C4J89_RS19280	COG2885	chlorophyll binding
C4J89_RS19305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J89_RS19320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4J89_RS19325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J89_RS19340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J89_RS19345	COG1045	serine acetyltransferase
C4J89_RS19350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J89_RS19365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4J89_RS19370	COG0372	Belongs to the citrate synthase family
C4J89_RS19380	COG1802	Transcriptional regulator
C4J89_RS19385	COG0189	ligase activity
C4J89_RS19385	COG4067	protein conserved in archaea
C4J89_RS19395	COG0189	ligase activity
C4J89_RS19400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J89_RS19415	COG0560	Phosphoserine phosphatase
C4J89_RS19425	COG1953	Uracil, thiamine, allantoin
C4J89_RS19435	COG0583	DNA-binding transcription factor activity
C4J89_RS19440	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS19445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J89_RS19475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J89_RS19475	COG2169	Transcriptional regulator
C4J89_RS19500	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J89_RS19520	COG0431	NADPH-dependent FMN reductase
C4J89_RS19580	COG0653	protein targeting
C4J89_RS19605	COG1475	DNA binding
C4J89_RS19655	COG0598	Magnesium transport protein CorA
C4J89_RS19660	COG0519	Catalyzes the synthesis of GMP from XMP
C4J89_RS19660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J89_RS19665	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J89_RS19665	COG1024	Enoyl-CoA hydratase
C4J89_RS19670	COG0183	Belongs to the thiolase family
C4J89_RS19680	COG1305	Transglutaminase-like
C4J89_RS19690	COG2308	Evidence 4 Homologs of previously reported genes of
C4J89_RS19720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J89_RS19725	COG3047	cAMP biosynthetic process
C4J89_RS19725	COG2885	chlorophyll binding
C4J89_RS19755	COG2207	Transcriptional regulator
C4J89_RS19760	COG1064	alcohol dehydrogenase
C4J89_RS19765	COG1414	Transcriptional regulator
C4J89_RS19770	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J89_RS19775	COG1129	ABC transporter
C4J89_RS19780	COG1879	ABC-type sugar transport system periplasmic component
C4J89_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS19810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J89_RS19820	COG1397	ADP-ribosylglycohydrolase
C4J89_RS19825	COG2188	Transcriptional regulator
C4J89_RS19840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J89_RS19850	COG0084	hydrolase, TatD family'
C4J89_RS19860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J89_RS19865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4J89_RS19870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J89_RS19875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J89_RS19880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J89_RS19895	COG0416	fatty acid biosynthetic process
C4J89_RS19900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4J89_RS19905	COG1399	metal-binding, possibly nucleic acid-binding protein
C4J89_RS19910	COG0424	maF-like protein
C4J89_RS19915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J89_RS19915	COG0616	signal peptide processing
C4J89_RS19920	COG0546	phosphoglycolate phosphatase activity
C4J89_RS19930	COG1530	ribonuclease E activity
C4J89_RS19935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J89_RS19940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4J89_RS19940	COG3608	succinylglutamate desuccinylase aspartoacylase
C4J89_RS19955	COG1301	dicarboxylic acid transport
C4J89_RS19960	COG4977	sequence-specific DNA binding
C4J89_RS19960	COG1917	Cupin 2, conserved barrel domain protein
C4J89_RS19985	COG2205	protein histidine kinase activity
C4J89_RS19990	COG0745	RESPONSE REGULATOR receiver
C4J89_RS20010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4J89_RS20020	COG1815	bacterial-type flagellum-dependent cell motility
C4J89_RS20025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J89_RS20030	COG0835	chemotaxis
C4J89_RS20030	COG0784	Response regulator, receiver
C4J89_RS20050	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4J89_RS20055	COG0477	Major facilitator Superfamily
C4J89_RS20110	COG2239	Acts as a magnesium transporter
C4J89_RS20130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J89_RS20135	COG0527	aspartate kinase activity
C4J89_RS20140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J89_RS20145	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4J89_RS20150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J89_RS20155	COG2988	succinylglutamate desuccinylase activity
C4J89_RS20165	COG3724	N-succinylarginine dihydrolase activity
C4J89_RS20170	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS20185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J89_RS20220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS20230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J89_RS20240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J89_RS20270	COG0154	amidase activity
C4J89_RS20305	COG0504	CTP synthase activity
C4J89_RS20310	COG2329	Antibiotic biosynthesis monooxygenase
C4J89_RS20325	COG0584	glycerophosphoryl diester phosphodiesterase
C4J89_RS20340	COG0306	phosphate transporter
C4J89_RS20345	COG0583	DNA-binding transcription factor activity
C4J89_RS20350	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS20360	COG0583	DNA-binding transcription factor activity
C4J89_RS20375	COG3550	peptidyl-serine autophosphorylation
C4J89_RS20385	COG0436	Aminotransferase
C4J89_RS20400	COG3265	gluconokinase activity
C4J89_RS20405	COG1609	Transcriptional regulator
C4J89_RS20410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J89_RS20440	COG2271	Major facilitator Superfamily
C4J89_RS20450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J89_RS20460	COG0242	peptide deformylase activity
C4J89_RS20465	COG1295	ribonuclease BN
C4J89_RS20470	COG3237	CsbD-like
C4J89_RS20480	COG0318	PFAM AMP-dependent synthetase and ligase
C4J89_RS20485	COG0318	PFAM AMP-dependent synthetase and ligase
C4J89_RS20495	COG2030	dehydratase
C4J89_RS20505	COG3530	Putative quorum-sensing-regulated virulence factor
C4J89_RS20510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J89_RS20515	COG0800	Aldolase
C4J89_RS20530	COG1737	Transcriptional regulator
C4J89_RS20535	COG0676	glucose-6-phosphate 1-epimerase activity
C4J89_RS20545	COG3842	ATPase activity
C4J89_RS20550	COG0395	ABC-type sugar transport system, permease component
C4J89_RS20555	COG1175	transmembrane transport
C4J89_RS20560	COG1653	transport
C4J89_RS20565	COG2942	2-epimerase
C4J89_RS20575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J89_RS20580	COG0583	DNA-binding transcription factor activity
C4J89_RS20595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4J89_RS20615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4J89_RS20650	COG1113	amino acid transport
C4J89_RS20670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4J89_RS20680	COG0009	L-threonylcarbamoyladenylate synthase
C4J89_RS20685	COG0613	PHP domain protein
C4J89_RS20690	COG2917	probably involved in intracellular septation
C4J89_RS20695	COG2350	Protein conserved in bacteria
C4J89_RS20705	COG0745	RESPONSE REGULATOR receiver
C4J89_RS20715	COG0642	Histidine kinase
C4J89_RS20765	COG0509	glycine decarboxylation via glycine cleavage system
C4J89_RS20770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J89_RS20770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J89_RS20775	COG1760	l-serine dehydratase
C4J89_RS20780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J89_RS20785	COG1278	Cold shock
C4J89_RS20800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4J89_RS20840	COG1538	Outer membrane efflux protein
C4J89_RS20850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J89_RS20860	COG0602	queuosine metabolic process
C4J89_RS20865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4J89_RS20870	COG2885	chlorophyll binding
C4J89_RS20875	COG0823	Involved in the tonB-independent uptake of proteins
C4J89_RS20895	COG0824	Thioesterase
C4J89_RS20905	COG2255	four-way junction helicase activity
C4J89_RS20910	COG0632	four-way junction helicase activity
C4J89_RS20915	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4J89_RS20920	COG0217	transcriptional regulatory protein
C4J89_RS20925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4J89_RS20940	COG0783	Belongs to the Dps family
C4J89_RS20950	COG2900	Belongs to the SlyX family
C4J89_RS20965	COG0668	transmembrane transport
C4J89_RS20970	COG1666	GTP binding
C4J89_RS20980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS20980	COG4191	Histidine kinase
C4J89_RS20985	COG2096	Adenosyltransferase
C4J89_RS21000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4J89_RS21005	COG0653	protein targeting
C4J89_RS21015	COG0433	COG0433 Predicted ATPase
C4J89_RS21025	COG0438	transferase activity, transferring glycosyl groups
C4J89_RS21025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J89_RS21040	COG0788	formyltetrahydrofolate deformylase activity
C4J89_RS21050	COG2925	Exonuclease
C4J89_RS21075	COG0714	Associated with various cellular activities
C4J89_RS21095	COG0469	pyruvate kinase activity
C4J89_RS21115	COG4191	Histidine kinase
C4J89_RS21125	COG0477	Major facilitator Superfamily
C4J89_RS21150	COG2207	Transcriptional regulator
C4J89_RS21180	COG1595	DNA-templated transcription, initiation
C4J89_RS21190	COG4771	TonB-dependent receptor
C4J89_RS21200	COG2832	Protein of unknown function (DUF454)
C4J89_RS21205	COG0840	transmembrane signaling receptor activity
C4J89_RS21235	COG3642	lipopolysaccharide core region biosynthetic process
C4J89_RS21245	COG0642	Histidine kinase
C4J89_RS21255	COG1368	sulfuric ester hydrolase activity
C4J89_RS21265	COG0459	protein refolding
C4J89_RS21270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4J89_RS21295	COG2211	Major facilitator Superfamily
C4J89_RS21300	COG0442	prolyl-tRNA aminoacylation
C4J89_RS21310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4J89_RS21370	COG4974	Belongs to the 'phage' integrase family
C4J89_RS21375	COG0335	large ribosomal subunit rRNA binding
C4J89_RS21380	COG0336	Belongs to the RNA methyltransferase TrmD family
C4J89_RS21385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4J89_RS21390	COG0228	four-way junction DNA binding
C4J89_RS21395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4J89_RS21405	COG4536	flavin adenine dinucleotide binding
C4J89_RS21410	COG0477	Major facilitator Superfamily
C4J89_RS21420	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4J89_RS21440	COG0494	nUDIX hydrolase
C4J89_RS21445	COG2816	NAD+ diphosphatase activity
C4J89_RS21455	COG2188	Transcriptional regulator
C4J89_RS21460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4J89_RS21465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J89_RS21470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J89_RS21470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J89_RS21475	COG2190	(PTS) system
C4J89_RS21475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J89_RS21475	COG1263	PTS System
C4J89_RS21490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4J89_RS21495	COG0047	phosphoribosylformylglycinamidine synthase activity
C4J89_RS21495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J89_RS21500	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J89_RS21515	COG1396	sequence-specific DNA binding
C4J89_RS21525	COG0519	Catalyzes the synthesis of GMP from XMP
C4J89_RS21525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J89_RS21545	COG1570	exodeoxyribonuclease VII activity
C4J89_RS21550	COG0739	heme binding
C4J89_RS21560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J89_RS21570	COG0436	Aminotransferase
C4J89_RS21575	COG1160	GTP binding
C4J89_RS21590	COG0124	histidyl-tRNA synthetase
C4J89_RS21595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J89_RS21600	COG1426	Protein conserved in bacteria
C4J89_RS21610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4J89_RS21615	COG0105	UTP biosynthetic process
C4J89_RS21625	COG0633	Ferredoxin
C4J89_RS21630	COG0443	Heat shock 70 kDa protein
C4J89_RS21635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J89_RS21640	COG0316	Belongs to the HesB IscA family
C4J89_RS21650	COG1104	cysteine desulfurase activity
C4J89_RS21675	COG3134	Outer membrane lipoprotein
C4J89_RS21690	COG1862	Preprotein translocase
C4J89_RS21695	COG0343	queuine tRNA-ribosyltransferase activity
C4J89_RS21700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4J89_RS21755	COG1522	sequence-specific DNA binding
C4J89_RS21765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J89_RS21780	COG1280	lysine exporter protein (LysE YggA)
C4J89_RS21820	COG4251	negative regulation of phosphorylation
C4J89_RS21835	COG2853	Lipoprotein
C4J89_RS21850	COG3706	GGDEF domain
C4J89_RS21865	COG1104	cysteine desulfurase activity
C4J89_RS21890	COG2197	response regulator
C4J89_RS21895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J89_RS21900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4J89_RS21905	COG0109	protoheme IX farnesyltransferase activity
C4J89_RS21915	COG1845	cytochrome c oxidase, subunit III
C4J89_RS21920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J89_RS21925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J89_RS21935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J89_RS21940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J89_RS21940	COG1017	nitric oxide dioxygenase activity
C4J89_RS21945	COG3604	Transcriptional regulator
C4J89_RS21955	COG3708	Transcriptional regulator
C4J89_RS21955	COG2207	Transcriptional regulator
C4J89_RS21960	COG2197	response regulator
C4J89_RS21975	COG1028	Short-chain dehydrogenase reductase Sdr
C4J89_RS21995	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J89_RS22020	COG0302	gtp cyclohydrolase
C4J89_RS22025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J89_RS22040	COG0492	ferredoxin-NADP+ reductase activity
C4J89_RS22050	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4J89_RS22065	COG0386	Belongs to the glutathione peroxidase family
C4J89_RS22070	COG3045	CreA protein
C4J89_RS22075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4J89_RS22080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4J89_RS22085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4J89_RS22090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4J89_RS22095	COG0142	geranyltranstransferase activity
C4J89_RS22100	COG2824	Alkylphosphonate utilization operon protein PhnA
C4J89_RS22105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J89_RS22110	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J89_RS22115	COG0840	transmembrane signaling receptor activity
C4J89_RS22125	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4J89_RS22135	COG2610	gluconate transmembrane transporter activity
C4J89_RS22145	COG0659	secondary active sulfate transmembrane transporter activity
C4J89_RS22155	COG0583	DNA-binding transcription factor activity
C4J89_RS22165	COG0583	DNA-binding transcription factor activity
C4J89_RS22170	COG1113	amino acid transport
C4J89_RS22180	COG1522	sequence-specific DNA binding
C4J89_RS22185	COG3485	protocatechuate 3,4-dioxygenase
C4J89_RS22190	COG4829	muconolactone delta-isomerase
C4J89_RS22195	COG4948	Mandelate Racemase Muconate Lactonizing
C4J89_RS22210	COG4638	Rieske (2fe-2S)
C4J89_RS22215	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4J89_RS22220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J89_RS22220	COG0543	2 iron, 2 sulfur cluster binding
C4J89_RS22225	COG1113	amino acid transport
C4J89_RS22230	COG3483	tryptophan 2,3-dioxygenase activity
C4J89_RS22235	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4J89_RS22280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J89_RS22285	COG1074	ATP-dependent DNA helicase activity
C4J89_RS22290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4J89_RS22325	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4J89_RS22330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J89_RS22335	COG1183	phosphatidylcholine synthase activity
C4J89_RS22340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4J89_RS22350	COG0028	Belongs to the TPP enzyme family
C4J89_RS22355	COG3098	single-species biofilm formation
C4J89_RS22365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J89_RS22385	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J89_RS22390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J89_RS22395	COG4558	Periplasmic binding protein
C4J89_RS22405	COG1489	DNA binding
C4J89_RS22410	COG0436	Aminotransferase
C4J89_RS22420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J89_RS22430	COG4191	Histidine kinase
C4J89_RS22450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J89_RS22455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4J89_RS22460	COG0166	Belongs to the GPI family
C4J89_RS22465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J89_RS22470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J89_RS22480	COG2823	Periplasmic or secreted lipoprotein
C4J89_RS22485	COG1185	polyribonucleotide nucleotidyltransferase activity
C4J89_RS22490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4J89_RS22495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4J89_RS22500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4J89_RS22505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4J89_RS22510	COG0195	Participates in both transcription termination and antitermination
C4J89_RS22515	COG0779	Required for maturation of 30S ribosomal subunits
C4J89_RS22530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J89_RS22535	COG0149	triose-phosphate isomerase activity
C4J89_RS22540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J89_RS22545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J89_RS22555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4J89_RS22570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J89_RS22575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4J89_RS22580	COG0505	Belongs to the CarA family
C4J89_RS22585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4J89_RS22590	COG0484	heat shock protein binding
C4J89_RS22595	COG0443	Heat shock 70 kDa protein
C4J89_RS22600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4J89_RS22605	COG0497	DNA recombination
C4J89_RS22610	COG0735	belongs to the Fur family
C4J89_RS22615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J89_RS22620	COG2914	Belongs to the UPF0125 (RnfH) family
C4J89_RS22630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4J89_RS22635	COG2186	Transcriptional regulator
C4J89_RS22640	COG1620	l-lactate permease
C4J89_RS22660	COG0582	viral genome integration into host DNA
C4J89_RS22680	COG4983	Phage plasmid primase, P4 family domain protein
C4J89_RS22780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J89_RS22785	COG3781	membrane
C4J89_RS22790	COG0583	DNA-binding transcription factor activity
C4J89_RS22800	COG2862	Uncharacterized protein family, UPF0114
C4J89_RS22815	COG1067	ATP-dependent peptidase activity
C4J89_RS22835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J89_RS22845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J89_RS22870	COG2814	Major facilitator Superfamily
C4J89_RS22875	COG0583	DNA-binding transcription factor activity
C4J89_RS22880	COG0488	(ABC) transporter
C4J89_RS22890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J89_RS22895	COG0523	cobalamin synthesis protein
C4J89_RS22900	COG2879	small protein
C4J89_RS22905	COG1966	Carbon starvation protein
C4J89_RS22925	COG1970	mechanosensitive ion channel activity
C4J89_RS22935	COG2197	response regulator
C4J89_RS22940	COG2813	Specifically methylates the guanine in position
C4J89_RS22950	COG1294	oxidase, subunit
C4J89_RS22955	COG1271	oxidase subunit
C4J89_RS22965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J89_RS22970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4J89_RS22975	COG2080	2 iron, 2 sulfur cluster binding
C4J89_RS22985	COG2252	PERMEase
C4J89_RS22990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J89_RS23005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J89_RS23010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J89_RS23015	COG1309	transcriptional regulator
C4J89_RS23020	COG1082	Xylose isomerase domain protein TIM barrel
C4J89_RS23020	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4J89_RS23025	COG0477	Major facilitator Superfamily
C4J89_RS23040	COG2321	neutral zinc metallopeptidase
C4J89_RS23055	COG1946	Acyl-CoA thioesterase
C4J89_RS23065	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4J89_RS23070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J89_RS23070	COG0493	'glutamate synthase
C4J89_RS23075	COG0513	Belongs to the DEAD box helicase family
C4J89_RS23080	COG0697	spore germination
C4J89_RS23100	COG1199	ATP-dependent helicase activity
C4J89_RS23100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J89_RS23110	COG3416	Protein conserved in bacteria
C4J89_RS23125	COG3622	Belongs to the hyi family
C4J89_RS23140	COG1643	Atp-dependent helicase
C4J89_RS23155	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4J89_RS23165	COG1522	sequence-specific DNA binding
C4J89_RS23180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J89_RS23185	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS23195	COG0351	phosphomethylpyrimidine kinase
C4J89_RS23200	COG0352	thiamine-phosphate diphosphorylase activity
C4J89_RS23205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J89_RS23220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J89_RS23225	COG1702	phosphate starvation-inducible protein PhoH
C4J89_RS23230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4J89_RS23235	COG4535	Mg2 and Co2 transporter CorC
C4J89_RS23240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4J89_RS23255	COG0495	leucyl-tRNA aminoacylation
C4J89_RS23265	COG1466	dna polymerase III delta subunit
C4J89_RS23275	COG2951	lytic endotransglycosylase activity
C4J89_RS23280	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4J89_RS23285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4J89_RS23290	COG0321	lipoyl(octanoyl) transferase activity
C4J89_RS23295	COG2921	Belongs to the UPF0250 family
C4J89_RS23300	COG1686	Belongs to the peptidase S11 family
C4J89_RS23310	COG2951	lytic endotransglycosylase activity
C4J89_RS23315	COG0772	Belongs to the SEDS family
C4J89_RS23320	COG0768	penicillin binding
C4J89_RS23325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4J89_RS23335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4J89_RS23340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4J89_RS23345	COG2094	Belongs to the DNA glycosylase MPG family
C4J89_RS23350	COG0586	Pfam SNARE associated Golgi protein
C4J89_RS23360	COG1346	cytolysis
C4J89_RS23380	COG0702	epimerase
C4J89_RS23395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J89_RS23400	COG3284	Transcriptional regulator
C4J89_RS23410	COG0531	amino acid
C4J89_RS23415	COG4303	Ethanolamine ammonia lyase large subunit
C4J89_RS23420	COG4302	ethanolamine ammonia-lyase activity
C4J89_RS23425	COG0456	acetyltransferase
C4J89_RS23430	COG0586	Pfam SNARE associated Golgi protein
C4J89_RS23435	COG3228	Belongs to the MtfA family
C4J89_RS23440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4J89_RS23460	COG1335	isochorismatase
C4J89_RS23465	COG4804	nuclease activity
C4J89_RS23470	COG1722	exodeoxyribonuclease VII activity
C4J89_RS23475	COG0142	geranyltranstransferase activity
C4J89_RS23480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J89_RS23485	COG4206	TonB-dependent receptor
C4J89_RS23500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J89_RS23510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4J89_RS23515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4J89_RS23520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J89_RS23535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J89_RS23535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J89_RS23540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4J89_RS23550	COG2264	protein methyltransferase activity
C4J89_RS23555	COG3118	belongs to the thioredoxin family
C4J89_RS23595	COG1201	RNA secondary structure unwinding
C4J89_RS23600	COG0668	transmembrane transport
C4J89_RS23610	COG3568	Endonuclease Exonuclease Phosphatase
C4J89_RS23620	COG0392	lysyltransferase activity
C4J89_RS23635	COG1335	isochorismatase
C4J89_RS23640	COG4106	trans-aconitate 2-methyltransferase activity
C4J89_RS23645	COG0629	single-stranded DNA binding
C4J89_RS23650	COG2814	Major facilitator Superfamily
C4J89_RS23655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J89_RS23660	COG2193	ferroxidase activity
C4J89_RS23670	COG0203	ribosomal protein L17
C4J89_RS23675	COG0202	RNA polymerase activity
C4J89_RS23680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4J89_RS23685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4J89_RS23690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4J89_RS23695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4J89_RS23705	COG0200	Binds to the 23S rRNA
C4J89_RS23710	COG1841	ribosomal large subunit assembly
C4J89_RS23715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4J89_RS23720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4J89_RS23725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4J89_RS23730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4J89_RS23735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J89_RS23740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4J89_RS23745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4J89_RS23750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4J89_RS23755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4J89_RS23760	COG0255	Belongs to the universal ribosomal protein uL29 family
C4J89_RS23765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4J89_RS23770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4J89_RS23775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4J89_RS23780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4J89_RS23785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4J89_RS23790	COG0089	rRNA binding
C4J89_RS23795	COG0088	Forms part of the polypeptide exit tunnel
C4J89_RS23800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4J89_RS23805	COG0051	transcription antitermination factor activity, RNA binding
C4J89_RS23810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J89_RS23815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J89_RS23820	COG0049	tRNA binding
C4J89_RS23825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4J89_RS23830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4J89_RS23835	COG0085	RNA polymerase activity
C4J89_RS23840	COG0222	ribosome binding
C4J89_RS23845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4J89_RS23850	COG0081	regulation of translation
C4J89_RS23855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4J89_RS23895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4J89_RS23935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4J89_RS23945	COG0739	heme binding
C4J89_RS23950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4J89_RS23955	COG0316	Belongs to the HesB IscA family
C4J89_RS23960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4J89_RS23965	COG1981	membrane
C4J89_RS23980	COG4221	oxidoreductase activity
C4J89_RS23985	COG0537	adenosine 5'-monophosphoramidase activity
C4J89_RS23990	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4J89_RS23995	COG1765	OsmC-like protein
C4J89_RS24010	COG0134	indole-3-glycerol-phosphate synthase activity
C4J89_RS24015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J89_RS24020	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J89_RS24025	COG3240	lipase activity
C4J89_RS24025	COG4625	pathogenesis
C4J89_RS24030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J89_RS24035	COG0546	phosphoglycolate phosphatase activity
C4J89_RS24040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4J89_RS24045	COG1454	alcohol dehydrogenase
C4J89_RS24055	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J89_RS24065	COG3842	ATPase activity
C4J89_RS24070	COG2197	response regulator
C4J89_RS24085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J89_RS24090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4J89_RS24095	COG3178	'Phosphotransferase
C4J89_RS24100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4J89_RS24105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J89_RS24110	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4J89_RS24115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J89_RS24125	COG2967	ApaG domain
C4J89_RS24130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J89_RS24140	COG2766	serine protein kinase
C4J89_RS24145	COG2718	Belongs to the UPF0229 family
C4J89_RS24150	COG2719	SpoVR family
C4J89_RS24155	COG0617	tRNA 3'-terminal CCA addition
C4J89_RS24165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J89_RS24170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4J89_RS24175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4J89_RS24180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4J89_RS24185	COG0358	DNA primase activity
C4J89_RS24190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J89_RS24220	COG0464	growth
C4J89_RS24250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J89_RS24255	COG1025	Belongs to the peptidase M16 family
C4J89_RS24265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J89_RS24270	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4J89_RS24280	COG0535	radical SAM domain protein
C4J89_RS24300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J89_RS24305	COG0583	DNA-binding transcription factor activity
C4J89_RS24310	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS24315	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS24325	COG1960	acyl-CoA dehydrogenase activity
C4J89_RS24345	COG1073	alpha beta
C4J89_RS24345	COG2226	methyltransferase
C4J89_RS24350	COG0156	8-amino-7-oxononanoate synthase activity
C4J89_RS24355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4J89_RS24365	COG2005	Transcriptional regulator
C4J89_RS24365	COG3585	molybdate ion transport
C4J89_RS24375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4J89_RS24395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4J89_RS24400	COG4566	intracellular signal transduction
C4J89_RS24400	COG0745	RESPONSE REGULATOR receiver
C4J89_RS24410	COG2176	DNA-directed DNA polymerase activity
C4J89_RS24415	COG1595	DNA-templated transcription, initiation
C4J89_RS24425	COG4774	siderophore transport
C4J89_RS24450	COG4452	Inner membrane protein CreD
C4J89_RS24455	COG2205	protein histidine kinase activity
C4J89_RS24460	COG0745	RESPONSE REGULATOR receiver
C4J89_RS24465	COG0189	ligase activity
C4J89_RS24465	COG4067	protein conserved in archaea
C4J89_RS24470	COG0204	Acyl-transferase
C4J89_RS24485	COG1063	alcohol dehydrogenase
C4J89_RS24515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J89_RS24540	COG1017	nitric oxide dioxygenase activity
C4J89_RS24540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J89_RS24545	COG4638	Rieske (2fe-2S)
C4J89_RS24560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4J89_RS24565	COG0247	lactate metabolic process
C4J89_RS24565	COG2181	nitrate reductase activity
C4J89_RS24570	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J89_RS24570	COG1902	pentaerythritol trinitrate reductase activity
C4J89_RS24610	COG3246	L-lysine catabolic process to acetate
C4J89_RS24615	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J89_RS24635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4J89_RS24640	COG0493	'glutamate synthase
C4J89_RS24645	COG0069	glutamate synthase activity
C4J89_RS24645	COG0067	glutamate synthase
C4J89_RS24645	COG0070	glutamate synthase
C4J89_RS24660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J89_RS24665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4J89_RS24695	COG0281	malic enzyme
C4J89_RS24705	COG0254	rRNA binding
C4J89_RS24710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4J89_RS24715	COG0018	arginyl-trna synthetase
C4J89_RS24725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4J89_RS24730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4J89_RS24775	COG2226	methyltransferase
C4J89_RS24785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J89_RS24790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J89_RS24795	COG0140	phosphoribosyl-ATP diphosphatase activity
C4J89_RS24800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J89_RS24805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J89_RS24845	COG2116	formate transmembrane transporter activity
C4J89_RS24855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4J89_RS24860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4J89_RS24875	COG0513	Belongs to the DEAD box helicase family
C4J89_RS24880	COG2353	YceI-like domain
C4J89_RS24885	COG3038	cytochrome b561
C4J89_RS24895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4J89_RS24900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS24915	COG1272	protein, Hemolysin III
C4J89_RS24940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4J89_RS24960	COG3052	prosthetic group binding
C4J89_RS24965	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4J89_RS24995	COG3093	addiction module antidote protein HigA
C4J89_RS25005	COG2198	Histidine kinase
C4J89_RS25005	COG0784	Response regulator, receiver
C4J89_RS25005	COG0643	Histidine kinase
C4J89_RS25030	COG0189	ligase activity
C4J89_RS25045	COG1678	Uncharacterized ACR, COG1678
C4J89_RS25050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4J89_RS25055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4J89_RS25060	COG0540	Belongs to the ATCase OTCase family
C4J89_RS25065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J89_RS25080	COG0791	NLP P60 protein
C4J89_RS25105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J89_RS25110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J89_RS25110	COG2813	Specifically methylates the guanine in position
C4J89_RS25120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4J89_RS25125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4J89_RS25135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4J89_RS25140	COG2022	thiamine diphosphate biosynthetic process
C4J89_RS25150	COG2363	Small membrane protein
C4J89_RS25155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J89_RS25165	COG2177	Part of the ABC transporter FtsEX involved in
C4J89_RS25170	COG2884	Cell division ATP-binding protein ftsE
C4J89_RS25175	COG0552	protein localization to endoplasmic reticulum
C4J89_RS25180	COG0612	Peptidase, M16
C4J89_RS25185	COG0612	Peptidase, M16
C4J89_RS25190	COG0742	ribosomal rna small subunit methyltransferase
C4J89_RS25195	COG0429	hydrolase of the alpha beta-hydrolase fold
C4J89_RS25210	COG1309	transcriptional regulator
C4J89_RS25225	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J89_RS25230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4J89_RS25235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J89_RS25240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J89_RS25250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J89_RS25260	COG0129	dihydroxy-acid dehydratase activity
C4J89_RS25270	COG1823	symporter activity
C4J89_RS25285	COG1160	GTP binding
C4J89_RS25295	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J89_RS25300	COG1178	ABC-type Fe3 transport system permease component
C4J89_RS25305	COG3842	ATPase activity
C4J89_RS25315	COG0583	DNA-binding transcription factor activity
C4J89_RS25325	COG0789	Transcriptional regulator
C4J89_RS25330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4J89_RS25335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4J89_RS25350	COG0494	nUDIX hydrolase
C4J89_RS25365	COG0702	epimerase
C4J89_RS25375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J89_RS25380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4J89_RS25385	COG2234	aminopeptidase activity
C4J89_RS25390	COG3204	pilus organization
C4J89_RS25395	COG3204	pilus organization
C4J89_RS25400	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J89_RS25405	COG0277	FAD linked oxidase domain protein
C4J89_RS25415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J89_RS25425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS25465	COG1177	transmembrane transport
C4J89_RS25470	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J89_RS25475	COG3842	ATPase activity
C4J89_RS25495	COG0174	glutamine synthetase
C4J89_RS25500	COG0174	glutamine synthetase
C4J89_RS25515	COG1116	anion transmembrane transporter activity
C4J89_RS25520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J89_RS25530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J89_RS25535	COG0431	NADPH-dependent FMN reductase
C4J89_RS25540	COG0450	alkyl hydroperoxide reductase
C4J89_RS25550	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4J89_RS25550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J89_RS25565	COG1522	sequence-specific DNA binding
C4J89_RS25575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J89_RS25580	COG0330	HflC and HflK could
C4J89_RS25595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J89_RS25600	COG0509	glycine decarboxylation via glycine cleavage system
C4J89_RS25605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J89_RS25610	COG1178	ABC-type Fe3 transport system permease component
C4J89_RS25620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J89_RS25630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J89_RS25635	COG0006	proline dipeptidase activity
C4J89_RS25640	COG3079	Belongs to the UPF0149 family
C4J89_RS25660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4J89_RS25685	COG2271	Major facilitator Superfamily
C4J89_RS25715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4J89_RS25735	COG2186	Transcriptional regulator
C4J89_RS25740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS25745	COG0765	amino acid transport
C4J89_RS25750	COG0765	amino acid transport
C4J89_RS25755	COG1126	abc transporter atp-binding protein
C4J89_RS25765	COG3188	usher protein
C4J89_RS25770	COG3121	Chaperone
C4J89_RS25785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4J89_RS25795	COG0586	Pfam SNARE associated Golgi protein
C4J89_RS25805	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4J89_RS25810	COG1671	Belongs to the UPF0178 family
C4J89_RS25815	COG0672	)-iron permease
C4J89_RS25820	COG1280	lysine exporter protein (LysE YggA)
C4J89_RS25830	COG0488	(ABC) transporter
C4J89_RS25855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J89_RS25870	COG0181	hydroxymethylbilane synthase activity
C4J89_RS25880	COG0165	Argininosuccinate lyase
C4J89_RS25885	COG0625	glutathione transferase activity
C4J89_RS25905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J89_RS25915	COG1965	Belongs to the frataxin family
C4J89_RS25925	COG0019	diaminopimelate decarboxylase activity
C4J89_RS25930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J89_RS25940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J89_RS25945	COG1011	Hydrolase
C4J89_RS25955	COG0432	Pfam Uncharacterised protein family UPF0047
C4J89_RS25960	COG0004	ammonium transporteR
C4J89_RS25965	COG0347	Belongs to the P(II) protein family
C4J89_RS25975	COG0606	chelatase, subunit chli
C4J89_RS25980	COG0840	transmembrane signaling receptor activity
C4J89_RS25985	COG0583	DNA-binding transcription factor activity
C4J89_RS25990	COG0534	Mate efflux family protein
C4J89_RS26005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J89_RS26010	COG0427	acetyl-CoA hydrolase
C4J89_RS26030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4J89_RS26035	COG0251	oxidation-reduction process
C4J89_RS26040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS26055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J89_RS26065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J89_RS26070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J89_RS26075	COG1012	belongs to the aldehyde dehydrogenase family
C4J89_RS26085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J89_RS26090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J89_RS26095	COG0747	negative chemotaxis
C4J89_RS26100	COG2003	Belongs to the UPF0758 family
C4J89_RS26105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4J89_RS26110	COG0756	dUTP diphosphatase activity
C4J89_RS26120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J89_RS26125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J89_RS26130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4J89_RS26135	COG0708	Exodeoxyribonuclease III
C4J89_RS26145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4J89_RS26150	COG1561	YicC-like family, N-terminal region
C4J89_RS26155	COG0194	GDP metabolic process
C4J89_RS26160	COG1758	RNA polymerase activity
C4J89_RS26165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J89_RS26190	COG0848	biopolymer transport protein
C4J89_RS26200	COG0583	DNA-binding transcription factor activity
C4J89_RS26205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4J89_RS26235	COG1136	(ABC) transporter
C4J89_RS26240	COG0515	serine threonine protein kinase
C4J89_RS26240	COG2815	serine threonine protein kinase
C4J89_RS26245	COG0631	protein serine/threonine phosphatase activity
C4J89_RS26355	COG3161	chorismate lyase activity
C4J89_RS26360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4J89_RS26380	COG1253	flavin adenine dinucleotide binding
C4J89_RS26390	COG0704	Plays a role in the regulation of phosphate uptake
C4J89_RS26395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J89_RS26400	COG0573	inorganic phosphate transmembrane transporter activity
C4J89_RS26425	COG0477	Major facilitator Superfamily
C4J89_RS26430	COG1607	acyl-coa hydrolase
C4J89_RS26435	COG0676	glucose-6-phosphate 1-epimerase activity
C4J89_RS26460	COG0583	DNA-binding transcription factor activity
C4J89_RS26465	COG1027	Aspartate ammonia-lyase
C4J89_RS26470	COG1115	amino acid carrier protein
C4J89_RS26475	COG0252	asparaginase activity
C4J89_RS26485	COG2808	Putative FMN-binding domain
C4J89_RS26505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J89_RS26510	COG0765	amino acid transport
C4J89_RS26520	COG0511	ligase activity, forming carbon-carbon bonds
C4J89_RS26520	COG5016	pyruvate
C4J89_RS26525	COG0439	Biotin carboxylase
C4J89_RS26530	COG0583	DNA-binding transcription factor activity
C4J89_RS26545	COG3300	MHYT domain
C4J89_RS26545	COG5001	Diguanylate cyclase
C4J89_RS26550	COG0210	DNA helicase
C4J89_RS26570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J89_RS26570	COG4651	solute:proton antiporter activity
C4J89_RS26575	COG1607	acyl-coa hydrolase
C4J89_RS26580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4J89_RS26590	COG0523	cobalamin synthesis protein
C4J89_RS26610	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J89_RS26615	COG1469	GTP cyclohydrolase I activity
C4J89_RS26620	COG1121	(ABC) transporter
C4J89_RS26640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J89_RS26645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J89_RS26655	COG3220	belongs to the UPF0276 family
C4J89_RS26685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4J89_RS26690	COG2267	carboxylic ester hydrolase activity
C4J89_RS26695	COG2453	phosphatase
C4J89_RS26695	COG0671	phosphoesterase, PA-phosphatase related
C4J89_RS26710	COG4589	Belongs to the CDS family
C4J89_RS26720	COG1309	transcriptional regulator
C4J89_RS26735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J89_RS26740	COG1349	DNA-binding transcription factor activity
C4J89_RS26750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J89_RS26755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4J89_RS26760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4J89_RS26765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4J89_RS26770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4J89_RS26775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J89_RS26780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4J89_RS26790	COG0356	it plays a direct role in the translocation of protons across the membrane
C4J89_RS26795	COG3312	ion transport
C4J89_RS26800	COG1475	DNA binding
C4J89_RS26805	COG1192	Involved in chromosome partitioning
C4J89_RS26810	COG0357	Ribosomal RNA small subunit methyltransferase G
C4J89_RS26815	COG0445	tRNA wobble uridine modification
C4J89_RS26820	COG1595	DNA-templated transcription, initiation
C4J89_RS26825	COG3712	iron ion homeostasis
C4J89_RS26830	COG4774	siderophore transport
C4J89_RS26835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4J89_RS26840	COG0706	membrane insertase activity
C4J89_RS26845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4J89_RS26850	COG0594	ribonuclease P activity
C4J89_RS26855	COG0230	Belongs to the bacterial ribosomal protein bL34 family