locus-tag	class	description
C4J88_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J88_RS00010	COG0592	DNA-directed DNA polymerase activity
C4J88_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J88_RS00020	COG0187	DNA topoisomerase II activity
C4J88_RS00025	COG0745	RESPONSE REGULATOR receiver
C4J88_RS00030	COG5002	protein histidine kinase activity
C4J88_RS00040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4J88_RS00045	COG0751	glycine-tRNA ligase activity
C4J88_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
C4J88_RS00055	COG2818	Glycosylase
C4J88_RS00070	COG0569	domain protein
C4J88_RS00075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4J88_RS00080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J88_RS00085	COG0242	peptide deformylase activity
C4J88_RS00095	COG0758	DNA mediated transformation
C4J88_RS00100	COG0009	L-threonylcarbamoyladenylate synthase
C4J88_RS00110	COG0408	coproporphyrinogen oxidase activity
C4J88_RS00115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J88_RS00130	COG3119	arylsulfatase activity
C4J88_RS00135	COG0583	DNA-binding transcription factor activity
C4J88_RS00145	COG3734	2-keto-3-deoxy-galactonokinase
C4J88_RS00150	COG0800	Aldolase
C4J88_RS00155	COG4948	Mandelate Racemase Muconate Lactonizing
C4J88_RS00160	COG2271	Major facilitator Superfamily
C4J88_RS00165	COG0159	tryptophan synthase activity
C4J88_RS00185	COG3360	Dodecin
C4J88_RS00195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J88_RS00200	COG1764	response to oxidative stress
C4J88_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4J88_RS00240	COG0339	signal peptide processing
C4J88_RS00280	COG0659	secondary active sulfate transmembrane transporter activity
C4J88_RS00290	COG1565	acr, cog1565
C4J88_RS00290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J88_RS00295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J88_RS00300	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4J88_RS00330	COG0109	protoheme IX farnesyltransferase activity
C4J88_RS00340	COG1464	Belongs to the NlpA lipoprotein family
C4J88_RS00345	COG2011	ABC-type metal ion transport system permease component
C4J88_RS00350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J88_RS00365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J88_RS00370	COG1121	(ABC) transporter
C4J88_RS00375	COG0735	belongs to the Fur family
C4J88_RS00380	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4J88_RS00400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4J88_RS00415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4J88_RS00430	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J88_RS00435	COG5002	protein histidine kinase activity
C4J88_RS00440	COG2204	response regulator
C4J88_RS00450	COG5487	UPF0391 membrane protein
C4J88_RS00460	COG1301	dicarboxylic acid transport
C4J88_RS00465	COG0700	Nucleoside recognition
C4J88_RS00480	COG1127	ABC transporter
C4J88_RS00485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J88_RS00495	COG0612	Peptidase, M16
C4J88_RS00500	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4J88_RS00505	COG0861	Integral membrane protein TerC family
C4J88_RS00510	COG2851	Citrate transporter
C4J88_RS00540	COG0427	acetyl-CoA hydrolase
C4J88_RS00565	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS00570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J88_RS00610	COG0840	transmembrane signaling receptor activity
C4J88_RS00640	COG5001	Diguanylate cyclase
C4J88_RS00640	COG3300	MHYT domain
C4J88_RS00660	COG2274	protein secretion by the type I secretion system
C4J88_RS00665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS00670	COG2175	clavaminate synthase activity
C4J88_RS00765	COG0529	Catalyzes the synthesis of activated sulfate
C4J88_RS00780	COG1289	transmembrane transporter activity
C4J88_RS00805	COG5339	Protein conserved in bacteria
C4J88_RS00810	COG0457	Tetratricopeptide repeat
C4J88_RS00815	COG0726	polysaccharide deacetylase
C4J88_RS00815	COG1649	PFAM Uncharacterised BCR, COG1649
C4J88_RS00820	COG1215	transferase activity, transferring glycosyl groups
C4J88_RS00925	COG2304	oxidoreductase activity
C4J88_RS00970	COG0484	heat shock protein binding
C4J88_RS01000	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J88_RS01015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J88_RS01020	COG2199	diguanylate cyclase activity
C4J88_RS01040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J88_RS01050	COG4208	sulfate ABC transporter
C4J88_RS01055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4J88_RS01065	COG2351	hydroxyisourate hydrolase activity
C4J88_RS01095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J88_RS01100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J88_RS01130	COG4771	TonB-dependent receptor
C4J88_RS01135	COG2807	transmembrane transport
C4J88_RS01175	COG0765	amino acid transport
C4J88_RS01180	COG0765	amino acid transport
C4J88_RS01185	COG1126	abc transporter atp-binding protein
C4J88_RS01190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS01200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4J88_RS01230	COG2011	ABC-type metal ion transport system permease component
C4J88_RS01235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J88_RS01240	COG1464	Belongs to the NlpA lipoprotein family
C4J88_RS01270	COG1126	abc transporter atp-binding protein
C4J88_RS01275	COG0765	amino acid transport
C4J88_RS01280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS01290	COG1045	serine acetyltransferase
C4J88_RS01295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J88_RS01300	COG0667	Aldo Keto reductase
C4J88_RS01305	COG2175	clavaminate synthase activity
C4J88_RS01310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J88_RS01315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4J88_RS01320	COG4521	taurine ABC transporter
C4J88_RS01325	COG2918	glutathione biosynthetic process
C4J88_RS01335	COG2183	response to ionizing radiation
C4J88_RS01350	COG0189	ligase activity
C4J88_RS01355	COG0189	ligase activity
C4J88_RS01355	COG4067	protein conserved in archaea
C4J88_RS01360	COG2200	EAL domain
C4J88_RS01365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4J88_RS01375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4J88_RS01380	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4J88_RS01405	COG2184	nucleotidyltransferase activity
C4J88_RS01420	COG0514	ATP-dependent DNA helicase (RecQ)
C4J88_RS01425	COG0824	Thioesterase
C4J88_RS01435	COG0243	molybdopterin cofactor binding
C4J88_RS01440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4J88_RS01445	COG1652	LysM domain
C4J88_RS01450	COG1011	Hydrolase
C4J88_RS01455	COG0494	nUDIX hydrolase
C4J88_RS01460	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4J88_RS01500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J88_RS01505	COG2957	Belongs to the agmatine deiminase family
C4J88_RS01545	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS01550	COG1309	transcriptional regulator
C4J88_RS01560	COG1196	nuclear chromosome segregation
C4J88_RS01635	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4J88_RS01640	COG1194	a g-specific adenine glycosylase
C4J88_RS01650	COG2223	nitrite transmembrane transporter activity
C4J88_RS01655	COG0131	Imidazoleglycerol-phosphate dehydratase
C4J88_RS01660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4J88_RS01670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4J88_RS01675	COG0107	imidazoleglycerol-phosphate synthase activity
C4J88_RS01685	COG2861	carbohydrate metabolic process
C4J88_RS01690	COG0793	Belongs to the peptidase S41A family
C4J88_RS01695	COG4942	peptidase
C4J88_RS01700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4J88_RS01705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J88_RS01715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4J88_RS01740	COG3852	Histidine kinase
C4J88_RS01760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J88_RS01760	COG0301	tRNA thio-modification
C4J88_RS01765	COG1217	gtp-binding protein TYPA
C4J88_RS01775	COG0058	SHG alpha-glucan phosphorylase activity
C4J88_RS01790	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4J88_RS01805	COG0402	S-adenosylhomocysteine deaminase activity
C4J88_RS01810	COG2188	Transcriptional regulator
C4J88_RS01820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4J88_RS01825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J88_RS01835	COG4176	ABC-type proline glycine betaine transport system permease component
C4J88_RS01840	COG0517	IMP dehydrogenase activity
C4J88_RS01840	COG4175	Glycine betaine
C4J88_RS01845	COG2986	histidine ammonia-lyase
C4J88_RS01850	COG2986	histidine ammonia-lyase
C4J88_RS01860	COG1228	amidohydrolase
C4J88_RS01870	COG0596	Alpha beta hydrolase
C4J88_RS01875	COG1490	D-aminoacyl-tRNA deacylase activity
C4J88_RS01880	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J88_RS01885	COG2943	transferase activity, transferring hexosyl groups
C4J88_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS01900	COG0765	amino acid transport
C4J88_RS01905	COG1126	abc transporter atp-binding protein
C4J88_RS01910	COG0840	transmembrane signaling receptor activity
C4J88_RS01915	COG0840	transmembrane signaling receptor activity
C4J88_RS01930	COG1422	Protein of unknown function (DUF1090)
C4J88_RS01935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J88_RS01940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4J88_RS01945	COG0640	Transcriptional regulator
C4J88_RS01950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4J88_RS01955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4J88_RS01960	COG0126	phosphoglycerate kinase activity
C4J88_RS01995	COG1451	nucleotide metabolic process
C4J88_RS02005	COG2153	protein acetylation
C4J88_RS02015	COG1289	transmembrane transporter activity
C4J88_RS02020	COG2081	HI0933 family
C4J88_RS02025	COG0513	Belongs to the DEAD box helicase family
C4J88_RS02030	COG0477	Major facilitator Superfamily
C4J88_RS02050	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J88_RS02055	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS02060	COG1309	transcriptional regulator
C4J88_RS02065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4J88_RS02070	COG4175	Glycine betaine
C4J88_RS02085	COG1760	l-serine dehydratase
C4J88_RS02090	COG2814	Major facilitator Superfamily
C4J88_RS02095	COG0583	DNA-binding transcription factor activity
C4J88_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS02125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J88_RS02135	COG2226	methyltransferase
C4J88_RS02160	COG2986	histidine ammonia-lyase
C4J88_RS02175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J88_RS02185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J88_RS02190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J88_RS02205	COG1192	Involved in chromosome partitioning
C4J88_RS02215	COG3118	belongs to the thioredoxin family
C4J88_RS02225	COG5499	transcription regulator containing HTH domain
C4J88_RS02230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4J88_RS02235	COG3264	Mechanosensitive ion channel
C4J88_RS02235	COG1196	nuclear chromosome segregation
C4J88_RS02240	COG3263	regulation of cellular component size
C4J88_RS02260	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS02265	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J88_RS02265	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4J88_RS02265	COG0506	proline dehydrogenase activity
C4J88_RS02275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J88_RS02290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4J88_RS02295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J88_RS02315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4J88_RS02320	COG0859	PFAM glycosyl transferase family 9
C4J88_RS02325	COG0859	PFAM glycosyl transferase family 9
C4J88_RS02330	COG0438	transferase activity, transferring glycosyl groups
C4J88_RS02355	COG4772	TonB-dependent receptor
C4J88_RS02365	COG2192	nodulation
C4J88_RS02380	COG0438	transferase activity, transferring glycosyl groups
C4J88_RS02385	COG1215	transferase activity, transferring glycosyl groups
C4J88_RS02395	COG1132	(ABC) transporter
C4J88_RS02400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4J88_RS02400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4J88_RS02410	COG0667	Aldo Keto reductase
C4J88_RS02425	COG0583	DNA-binding transcription factor activity
C4J88_RS02430	COG1519	Transferase
C4J88_RS02435	COG1538	Outer membrane efflux protein
C4J88_RS02440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4J88_RS02455	COG0494	nUDIX hydrolase
C4J88_RS02465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J88_RS02485	COG3150	esterase
C4J88_RS02520	COG0688	phosphatidylethanolamine metabolic process
C4J88_RS02550	COG1162	GTPase activity
C4J88_RS02555	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4J88_RS02560	COG2860	membrane
C4J88_RS02570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4J88_RS02570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4J88_RS02575	COG0802	atpase or kinase
C4J88_RS02580	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J88_RS02585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4J88_RS02590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4J88_RS02595	COG1923	regulation of RNA biosynthetic process
C4J88_RS02600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4J88_RS02605	COG0330	HflC and HflK could
C4J88_RS02610	COG0330	HflC and HflK could
C4J88_RS02615	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4J88_RS02620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4J88_RS02630	COG1178	ABC-type Fe3 transport system permease component
C4J88_RS02635	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J88_RS02650	COG0557	exoribonuclease II activity
C4J88_RS02655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4J88_RS02660	COG0360	Binds together with S18 to 16S ribosomal RNA
C4J88_RS02665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4J88_RS02675	COG0359	binds to the 23S rRNA
C4J88_RS02680	COG0305	Participates in initiation and elongation during chromosome replication
C4J88_RS02690	COG1032	radical SAM domain protein
C4J88_RS02720	COG2308	Evidence 4 Homologs of previously reported genes of
C4J88_RS02720	COG2307	Protein conserved in bacteria
C4J88_RS02745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J88_RS02750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4J88_RS02755	COG0583	DNA-binding transcription factor activity
C4J88_RS02760	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS02765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS02775	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS02800	COG4221	oxidoreductase activity
C4J88_RS02820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4J88_RS02825	COG0830	nickel cation binding
C4J88_RS02830	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4J88_RS02835	COG0791	NLP P60 protein
C4J88_RS02840	COG1309	transcriptional regulator
C4J88_RS02850	COG2982	Protein involved in outer membrane biogenesis
C4J88_RS02870	COG0443	Heat shock 70 kDa protein
C4J88_RS02875	COG0484	heat shock protein binding
C4J88_RS02880	COG0804	urea catabolic process
C4J88_RS02885	COG0832	Belongs to the urease beta subunit family
C4J88_RS02900	COG0831	urea catabolic process
C4J88_RS02905	COG0829	nickel cation binding
C4J88_RS02915	COG0411	ABC transporter
C4J88_RS02995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J88_RS03020	COG2095	MarC family integral membrane protein
C4J88_RS03030	COG0151	Belongs to the GarS family
C4J88_RS03035	COG0138	bifunctional purine biosynthesis protein purh
C4J88_RS03045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J88_RS03060	COG2264	protein methyltransferase activity
C4J88_RS03080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J88_RS03105	COG0023	Translation Initiation Factor
C4J88_RS03110	COG1166	arginine decarboxylase activity
C4J88_RS03115	COG0534	Mate efflux family protein
C4J88_RS03120	COG2373	Large extracellular alpha-helical protein
C4J88_RS03130	COG4953	penicillin-binding protein 1C
C4J88_RS03140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J88_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS03180	COG2217	Heavy metal translocating P-type atpase
C4J88_RS03195	COG2814	Major facilitator Superfamily
C4J88_RS03200	COG0604	alcohol dehydrogenase
C4J88_RS03205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4J88_RS03210	COG0583	DNA-binding transcription factor activity
C4J88_RS03220	COG0477	Major facilitator Superfamily
C4J88_RS03225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4J88_RS03230	COG0387	Pfam Sodium calcium exchanger
C4J88_RS03250	COG1309	transcriptional regulator
C4J88_RS03305	COG2995	paraquat-inducible protein a
C4J88_RS03310	COG2995	paraquat-inducible protein a
C4J88_RS03315	COG3008	intermembrane lipid transfer
C4J88_RS03340	COG0456	acetyltransferase
C4J88_RS03350	COG0288	reversible hydration of carbon dioxide
C4J88_RS03375	COG2031	fatty acid transporter
C4J88_RS03380	COG0477	Major facilitator Superfamily
C4J88_RS03400	COG0405	Gamma-glutamyltransferase
C4J88_RS03435	COG1157	protein secretion by the type III secretion system
C4J88_RS03460	COG4794	Type iii secretion
C4J88_RS03470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J88_RS03505	COG4669	(LipO)protein
C4J88_RS03530	COG0193	aminoacyl-tRNA hydrolase activity
C4J88_RS03535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4J88_RS03540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4J88_RS03550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4J88_RS03555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4J88_RS03565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4J88_RS03570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4J88_RS03580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4J88_RS03585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4J88_RS03605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J88_RS03620	COG4221	oxidoreductase activity
C4J88_RS03625	COG0415	Belongs to the DNA photolyase family
C4J88_RS03630	COG0789	Transcriptional regulator
C4J88_RS03645	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4J88_RS03650	COG1090	epimerase
C4J88_RS03655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4J88_RS03665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J88_RS03675	COG0175	sulfate reduction
C4J88_RS03685	COG0204	Acyl-transferase
C4J88_RS03690	COG0280	phosphate acetyltransferase
C4J88_RS03690	COG0857	belongs to the CobB CobQ family
C4J88_RS03705	COG0268	Binds directly to 16S ribosomal RNA
C4J88_RS03715	COG0196	riboflavin kinase activity
C4J88_RS03720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4J88_RS03725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J88_RS03730	COG1047	Peptidyl-prolyl cis-trans
C4J88_RS03735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4J88_RS03765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS03790	COG0542	response to heat
C4J88_RS03815	COG1252	NADH dehydrogenase
C4J88_RS03840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4J88_RS03845	COG0237	dephospho-CoA kinase activity
C4J88_RS03885	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4J88_RS03905	COG0084	hydrolase, TatD family'
C4J88_RS03910	COG1609	Transcriptional regulator
C4J88_RS03920	COG1105	Belongs to the carbohydrate kinase PfkB family
C4J88_RS03925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J88_RS03925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4J88_RS03925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4J88_RS03935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4J88_RS03940	COG4774	siderophore transport
C4J88_RS03945	COG3128	pkhd-type hydroxylase
C4J88_RS03960	COG0019	diaminopimelate decarboxylase activity
C4J88_RS03985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4J88_RS03990	COG0489	protein tyrosine kinase activity
C4J88_RS04015	COG4608	Belongs to the ABC transporter superfamily
C4J88_RS04020	COG0444	Belongs to the ABC transporter superfamily
C4J88_RS04025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J88_RS04030	COG0601	transmembrane transport
C4J88_RS04035	COG0747	negative chemotaxis
C4J88_RS04045	COG0747	negative chemotaxis
C4J88_RS04050	COG0747	negative chemotaxis
C4J88_RS04055	COG0747	negative chemotaxis
C4J88_RS04075	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4J88_RS04080	COG4178	(ABC) transporter
C4J88_RS04095	COG0180	Tryptophanyl-tRNA synthetase
C4J88_RS04100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J88_RS04110	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS04120	COG0667	Aldo Keto reductase
C4J88_RS04125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4J88_RS04130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4J88_RS04135	COG0723	plastoquinol--plastocyanin reductase activity
C4J88_RS04140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4J88_RS04145	COG2857	Cytochrome c1
C4J88_RS04150	COG0625	glutathione transferase activity
C4J88_RS04155	COG2969	positive regulation of protein catabolic process
C4J88_RS04160	COG2186	Transcriptional regulator
C4J88_RS04170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J88_RS04180	COG2271	Major facilitator Superfamily
C4J88_RS04185	COG2721	sulfolactate sulfo-lyase activity
C4J88_RS04200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J88_RS04205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J88_RS04210	COG0154	amidase activity
C4J88_RS04215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4J88_RS04220	COG1077	Cell shape determining protein MreB Mrl
C4J88_RS04225	COG1792	Involved in formation and maintenance of cell shape
C4J88_RS04235	COG0424	maF-like protein
C4J88_RS04240	COG1530	ribonuclease E activity
C4J88_RS04250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J88_RS04255	COG0312	modulator of DNA gyrase
C4J88_RS04260	COG3028	Belongs to the UPF0307 family
C4J88_RS04265	COG0312	modulator of DNA gyrase
C4J88_RS04295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J88_RS04300	COG1660	Displays ATPase and GTPase activities
C4J88_RS04310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4J88_RS04315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4J88_RS04320	COG1137	ATPase activity
C4J88_RS04325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4J88_RS04335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4J88_RS04345	COG1127	ABC transporter
C4J88_RS04350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4J88_RS04355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4J88_RS04375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4J88_RS04380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4J88_RS04385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4J88_RS04390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J88_RS04400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4J88_RS04405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4J88_RS04460	COG2135	peptidase activity
C4J88_RS04465	COG0501	Belongs to the peptidase M48B family
C4J88_RS04470	COG2119	membrane
C4J88_RS04475	COG2813	Specifically methylates the guanine in position
C4J88_RS04480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J88_RS04485	COG1280	lysine exporter protein (LysE YggA)
C4J88_RS04490	COG0318	PFAM AMP-dependent synthetase and ligase
C4J88_RS04515	COG3008	intermembrane lipid transfer
C4J88_RS04520	COG2995	paraquat-inducible protein a
C4J88_RS04535	COG2885	chlorophyll binding
C4J88_RS04540	COG2823	Periplasmic or secreted lipoprotein
C4J88_RS04545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4J88_RS04550	COG0792	nuclease activity
C4J88_RS04570	COG2001	Belongs to the MraZ family
C4J88_RS04575	COG0275	rRNA processing
C4J88_RS04590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J88_RS04595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4J88_RS04600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J88_RS04605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4J88_RS04610	COG0772	Belongs to the SEDS family
C4J88_RS04615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J88_RS04620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J88_RS04625	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J88_RS04640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4J88_RS04645	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4J88_RS04650	COG2203	Gaf domain
C4J88_RS04650	COG3706	GGDEF domain
C4J88_RS04650	COG4251	negative regulation of phosphorylation
C4J88_RS04650	COG5001	Diguanylate cyclase
C4J88_RS04660	COG5002	protein histidine kinase activity
C4J88_RS04685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS04700	COG0835	chemotaxis
C4J88_RS04700	COG0784	Response regulator, receiver
C4J88_RS04705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J88_RS04710	COG0583	DNA-binding transcription factor activity
C4J88_RS04730	COG1566	PFAM secretion protein HlyD family protein
C4J88_RS04750	COG0300	oxidoreductase activity
C4J88_RS04760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J88_RS04760	COG0662	Cupin 2, conserved barrel domain protein
C4J88_RS04775	COG1696	Membrane protein involved in D-alanine export
C4J88_RS04790	COG3420	alginic acid biosynthetic process
C4J88_RS04800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4J88_RS04805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS04815	COG1215	transferase activity, transferring glycosyl groups
C4J88_RS04825	COG3022	response to hydroperoxide
C4J88_RS04835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4J88_RS04845	COG0315	cyclic pyranopterin monophosphate synthase activity
C4J88_RS04850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4J88_RS04870	COG0513	Belongs to the DEAD box helicase family
C4J88_RS04880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS04885	COG4597	amino acid ABC transporter
C4J88_RS04890	COG0765	amino acid transport
C4J88_RS04895	COG1126	abc transporter atp-binding protein
C4J88_RS04910	COG2186	Transcriptional regulator
C4J88_RS04915	COG2807	transmembrane transport
C4J88_RS04920	COG2205	protein histidine kinase activity
C4J88_RS04920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS04935	COG2827	Endonuclease containing a URI domain
C4J88_RS04940	COG4774	siderophore transport
C4J88_RS04945	COG2027	D-alanyl-D-alanine carboxypeptidase
C4J88_RS04955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4J88_RS04960	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J88_RS04980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4J88_RS05010	COG1760	l-serine dehydratase
C4J88_RS05015	COG0583	DNA-binding transcription factor activity
C4J88_RS05025	COG0477	Major facilitator Superfamily
C4J88_RS05030	COG0583	DNA-binding transcription factor activity
C4J88_RS05035	COG4772	TonB-dependent receptor
C4J88_RS05040	COG3712	iron ion homeostasis
C4J88_RS05045	COG1595	DNA-templated transcription, initiation
C4J88_RS05080	COG3081	Nucleoid-associated protein
C4J88_RS05090	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4J88_RS05095	COG0525	valine-tRNA ligase activity
C4J88_RS05110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4J88_RS05115	COG0795	lipopolysaccharide-transporting ATPase activity
C4J88_RS05120	COG0795	lipopolysaccharide-transporting ATPase activity
C4J88_RS05125	COG0481	GTPase activity
C4J88_RS05130	COG0681	Belongs to the peptidase S26 family
C4J88_RS05135	COG0571	ribonuclease III activity
C4J88_RS05140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4J88_RS05145	COG1381	Involved in DNA repair and RecF pathway recombination
C4J88_RS05150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4J88_RS05160	COG0590	tRNA wobble adenosine to inosine editing
C4J88_RS05165	COG0500	methyltransferase
C4J88_RS05170	COG2226	methyltransferase
C4J88_RS05180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J88_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS05225	COG0523	cobalamin synthesis protein
C4J88_RS05240	COG4206	TonB-dependent receptor
C4J88_RS05245	COG4628	conserved protein (DUF2132)
C4J88_RS05260	COG1695	Transcriptional regulator
C4J88_RS05315	COG1113	amino acid transport
C4J88_RS05325	COG0069	glutamate synthase activity
C4J88_RS05340	COG5002	protein histidine kinase activity
C4J88_RS05345	COG1858	cytochrome C peroxidase
C4J88_RS05360	COG0494	nUDIX hydrolase
C4J88_RS05375	COG0583	DNA-binding transcription factor activity
C4J88_RS05400	COG2076	Multidrug Resistance protein
C4J88_RS05415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4J88_RS05430	COG4191	Histidine kinase
C4J88_RS05435	COG2204	response regulator
C4J88_RS05455	COG1126	abc transporter atp-binding protein
C4J88_RS05460	COG0765	amino acid transport
C4J88_RS05465	COG0765	amino acid transport
C4J88_RS05470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS05485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4J88_RS05495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4J88_RS05500	COG3842	ATPase activity
C4J88_RS05505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4J88_RS05515	COG0243	molybdopterin cofactor binding
C4J88_RS05520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4J88_RS05535	COG0450	alkyl hydroperoxide reductase
C4J88_RS05540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J88_RS05545	COG0418	dihydroorotase activity
C4J88_RS05555	COG0137	argininosuccinate synthase activity
C4J88_RS05560	COG2197	response regulator
C4J88_RS05570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4J88_RS05575	COG2878	Part of a membrane complex involved in electron transport
C4J88_RS05580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J88_RS05580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4J88_RS05585	COG0489	protein tyrosine kinase activity
C4J88_RS05595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4J88_RS05695	COG3179	chitinase
C4J88_RS05705	COG1546	Belongs to the CinA family
C4J88_RS05710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4J88_RS05715	COG2137	regulation of response to DNA damage stimulus
C4J88_RS05730	COG3148	PFAM DTW domain containing protein
C4J88_RS05745	COG0583	DNA-binding transcription factor activity
C4J88_RS05760	COG4807	Protein conserved in bacteria
C4J88_RS05770	COG0519	Catalyzes the synthesis of GMP from XMP
C4J88_RS05775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J88_RS05805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4J88_RS05810	COG3158	transport of potassium into the cell
C4J88_RS05815	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS05825	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4J88_RS05845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J88_RS05845	COG0457	Tetratricopeptide repeat
C4J88_RS05860	COG2201	protein-glutamate methylesterase activity
C4J88_RS05865	COG3706	GGDEF domain
C4J88_RS05865	COG5001	Diguanylate cyclase
C4J88_RS05865	COG2203	Gaf domain
C4J88_RS05865	COG4251	negative regulation of phosphorylation
C4J88_RS05875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4J88_RS05890	COG1073	alpha beta
C4J88_RS05910	COG2885	chlorophyll binding
C4J88_RS05925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4J88_RS05930	COG0563	adenylate kinase activity
C4J88_RS05935	COG1214	PFAM Peptidase M22, glycoprotease
C4J88_RS05945	COG1801	Protein of unknown function DUF72
C4J88_RS05965	COG0742	ribosomal rna small subunit methyltransferase
C4J88_RS05975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS06000	COG2937	Belongs to the GPAT DAPAT family
C4J88_RS06015	COG2226	methyltransferase
C4J88_RS06020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4J88_RS06025	COG1215	transferase activity, transferring glycosyl groups
C4J88_RS06030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4J88_RS06035	COG2166	iron-sulfur cluster assembly
C4J88_RS06040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J88_RS06045	COG2171	N-acyltransferase activity
C4J88_RS06050	COG1393	Belongs to the ArsC family
C4J88_RS06055	COG0025	NhaP-type Na H and K H
C4J88_RS06070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4J88_RS06080	COG0052	Belongs to the universal ribosomal protein uS2 family
C4J88_RS06085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4J88_RS06090	COG0528	UMP kinase activity
C4J88_RS06095	COG0233	cytoplasmic translational termination
C4J88_RS06100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4J88_RS06110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4J88_RS06120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J88_RS06130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J88_RS06135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J88_RS06140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J88_RS06145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J88_RS06150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4J88_RS06155	COG0587	DNA-directed DNA polymerase activity
C4J88_RS06160	COG0825	malonyl-CoA metabolic process
C4J88_RS06165	COG0037	tRNA processing
C4J88_RS06170	COG0504	CTP synthase activity
C4J88_RS06175	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4J88_RS06180	COG0148	phosphopyruvate hydratase activity
C4J88_RS06190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4J88_RS06200	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4J88_RS06205	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4J88_RS06210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4J88_RS06215	COG0585	pseudouridine synthase activity
C4J88_RS06220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4J88_RS06225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4J88_RS06240	COG1278	Cold shock
C4J88_RS06245	COG0717	Belongs to the dCTP deaminase family
C4J88_RS06260	COG1201	RNA secondary structure unwinding
C4J88_RS06275	COG4160	amino acid transport
C4J88_RS06290	COG1793	dna ligase
C4J88_RS06300	COG2366	antibiotic biosynthetic process
C4J88_RS06305	COG0653	protein targeting
C4J88_RS06315	COG3012	SEC-C Motif Domain Protein
C4J88_RS06335	COG1199	ATP-dependent helicase activity
C4J88_RS06345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4J88_RS06355	COG0259	pyridoxamine-phosphate oxidase activity
C4J88_RS06365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J88_RS06375	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4J88_RS06390	COG0583	DNA-binding transcription factor activity
C4J88_RS06405	COG3220	belongs to the UPF0276 family
C4J88_RS06455	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4J88_RS06460	COG2271	Major facilitator Superfamily
C4J88_RS06465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J88_RS06475	COG0306	phosphate transporter
C4J88_RS06485	COG1414	Transcriptional regulator
C4J88_RS06490	COG2814	Major facilitator Superfamily
C4J88_RS06495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J88_RS06500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4J88_RS06505	COG0183	Belongs to the thiolase family
C4J88_RS06510	COG3485	protocatechuate 3,4-dioxygenase
C4J88_RS06515	COG3485	protocatechuate 3,4-dioxygenase
C4J88_RS06520	COG0477	Major facilitator Superfamily
C4J88_RS06530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J88_RS06535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J88_RS06560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS06565	COG1309	transcriptional regulator
C4J88_RS06570	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS06610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J88_RS06645	COG1454	alcohol dehydrogenase
C4J88_RS06650	COG2814	Major facilitator Superfamily
C4J88_RS06655	COG0156	8-amino-7-oxononanoate synthase activity
C4J88_RS06665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J88_RS06710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4J88_RS06725	COG2267	carboxylic ester hydrolase activity
C4J88_RS06755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4J88_RS06795	COG0354	folic acid binding
C4J88_RS06800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4J88_RS06830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4J88_RS06840	COG0425	Belongs to the sulfur carrier protein TusA family
C4J88_RS06845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4J88_RS06855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4J88_RS06860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4J88_RS06865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J88_RS06870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4J88_RS06880	COG2026	Addiction module toxin, RelE StbE family
C4J88_RS06885	COG3077	Addiction module antitoxin, RelB DinJ family
C4J88_RS06910	COG0583	DNA-binding transcription factor activity
C4J88_RS06935	COG2807	transmembrane transport
C4J88_RS06940	COG2910	NAD(P)H-binding
C4J88_RS06950	COG0583	DNA-binding transcription factor activity
C4J88_RS07055	COG5566	PFAM Mor transcription activator
C4J88_RS07100	COG4373	Mu-like prophage FluMu protein gp28
C4J88_RS07105	COG4383	Mu-like prophage protein gp29
C4J88_RS07135	COG4397	Mu-like prophage major head subunit gpT
C4J88_RS07240	COG3100	YcgL domain-containing protein
C4J88_RS07245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J88_RS07255	COG2983	Belongs to the UPF0260 family
C4J88_RS07295	COG1770	oligopeptidase
C4J88_RS07305	COG0121	glutamine amidotransferase
C4J88_RS07320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4J88_RS07325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4J88_RS07330	COG1984	allophanate hydrolase subunit 2
C4J88_RS07340	COG0542	response to heat
C4J88_RS07350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J88_RS07365	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4J88_RS07370	COG0425	Belongs to the sulfur carrier protein TusA family
C4J88_RS07380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J88_RS07385	COG1132	(ABC) transporter
C4J88_RS07395	COG0741	lytic transglycosylase activity
C4J88_RS07400	COG0488	(ABC) transporter
C4J88_RS07405	COG0589	response to stress
C4J88_RS07415	COG1024	Enoyl-CoA hydratase
C4J88_RS07415	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J88_RS07420	COG0183	Belongs to the thiolase family
C4J88_RS07465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J88_RS07470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4J88_RS07480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4J88_RS07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J88_RS07495	COG0584	glycerophosphoryl diester phosphodiesterase
C4J88_RS07505	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J88_RS07510	COG1136	(ABC) transporter
C4J88_RS07515	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4J88_RS07535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J88_RS07535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4J88_RS07550	COG2853	Lipoprotein
C4J88_RS07565	COG2204	response regulator
C4J88_RS07575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4J88_RS07580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J88_RS07625	COG2814	Major facilitator Superfamily
C4J88_RS07630	COG0579	oxidoreductase
C4J88_RS07635	COG0583	DNA-binding transcription factor activity
C4J88_RS07660	COG1611	Belongs to the LOG family
C4J88_RS07670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4J88_RS07690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J88_RS07700	COG0583	DNA-binding transcription factor activity
C4J88_RS07705	COG2814	Major facilitator Superfamily
C4J88_RS07715	COG2233	PERMEase
C4J88_RS07720	COG2267	carboxylic ester hydrolase activity
C4J88_RS07725	COG2197	response regulator
C4J88_RS07730	COG0596	Alpha beta hydrolase
C4J88_RS07740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J88_RS07745	COG0444	Belongs to the ABC transporter superfamily
C4J88_RS07755	COG0747	negative chemotaxis
C4J88_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS07765	COG0546	phosphoglycolate phosphatase activity
C4J88_RS07770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4J88_RS07775	COG0402	S-adenosylhomocysteine deaminase activity
C4J88_RS07780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4J88_RS07790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4J88_RS07800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J88_RS07805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J88_RS07810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4J88_RS07825	COG0776	regulation of translation
C4J88_RS07840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4J88_RS07845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J88_RS07850	COG0367	asparagine synthase
C4J88_RS07865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4J88_RS07895	COG0456	acetyltransferase
C4J88_RS07910	COG2244	polysaccharide biosynthetic process
C4J88_RS07915	COG1216	Glycosyl transferase, family 2
C4J88_RS07915	COG0463	Glycosyl transferase, family 2
C4J88_RS07925	COG1555	photosystem II stabilization
C4J88_RS07955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4J88_RS07965	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4J88_RS07970	COG2205	protein histidine kinase activity
C4J88_RS07975	COG0745	RESPONSE REGULATOR receiver
C4J88_RS08010	COG3209	COG3209 Rhs family protein
C4J88_RS08010	COG3209	COG3209 Rhs family protein
C4J88_RS08020	COG0084	hydrolase, TatD family'
C4J88_RS08025	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J88_RS08050	COG1131	(ABC) transporter
C4J88_RS08060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J88_RS08065	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4J88_RS08070	COG4181	ATPase activity
C4J88_RS08115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4J88_RS08135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J88_RS08150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4J88_RS08160	COG1764	response to oxidative stress
C4J88_RS08165	COG1846	Transcriptional regulator
C4J88_RS08170	COG0583	DNA-binding transcription factor activity
C4J88_RS08175	COG0730	response to heat
C4J88_RS08180	COG0583	DNA-binding transcription factor activity
C4J88_RS08190	COG3214	Protein conserved in bacteria
C4J88_RS08195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4J88_RS08205	COG1024	Enoyl-CoA hydratase
C4J88_RS08205	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J88_RS08220	COG3384	dioxygenase
C4J88_RS08225	COG0500	methyltransferase
C4J88_RS08230	COG0501	Belongs to the peptidase M48B family
C4J88_RS08235	COG0436	Aminotransferase
C4J88_RS08240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4J88_RS08245	COG0386	Belongs to the glutathione peroxidase family
C4J88_RS08250	COG5002	protein histidine kinase activity
C4J88_RS08250	COG0784	Response regulator, receiver
C4J88_RS08250	COG2205	protein histidine kinase activity
C4J88_RS08260	COG1956	GAF domain-containing protein
C4J88_RS08265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS08265	COG2205	protein histidine kinase activity
C4J88_RS08270	COG2197	response regulator
C4J88_RS08315	COG0564	pseudouridine synthase activity
C4J88_RS08325	COG0746	molybdenum cofactor guanylyltransferase activity
C4J88_RS08330	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4J88_RS08350	COG3237	CsbD-like
C4J88_RS08355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4J88_RS08365	COG4133	protoheme IX ABC transporter activity
C4J88_RS08385	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4J88_RS08390	COG1138	Cytochrome C-type biogenesis protein
C4J88_RS08400	COG3088	subunit of a heme lyase
C4J88_RS08405	COG4235	cytochrome complex assembly
C4J88_RS08415	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4J88_RS08430	COG2814	Major facilitator Superfamily
C4J88_RS08435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4J88_RS08440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J88_RS08450	COG0469	pyruvate kinase activity
C4J88_RS08460	COG2084	Dehydrogenase
C4J88_RS08465	COG3622	Belongs to the hyi family
C4J88_RS08470	COG3960	tartronate-semialdehyde synthase activity
C4J88_RS08480	COG1309	transcriptional regulator
C4J88_RS08485	COG2354	Protein conserved in bacteria
C4J88_RS08495	COG2853	Lipoprotein
C4J88_RS08515	COG2113	Glycine betaine
C4J88_RS08520	COG3162	membrane
C4J88_RS08525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4J88_RS08535	COG2009	succinate dehydrogenase
C4J88_RS08540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4J88_RS08545	COG1053	succinate dehydrogenase
C4J88_RS08550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4J88_RS08565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J88_RS08570	COG0045	succinate-CoA ligase (ADP-forming) activity
C4J88_RS08605	COG0326	Molecular chaperone. Has ATPase activity
C4J88_RS08615	COG1741	Belongs to the pirin family
C4J88_RS08635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4J88_RS08640	COG0784	Response regulator, receiver
C4J88_RS08640	COG5002	protein histidine kinase activity
C4J88_RS08640	COG2205	protein histidine kinase activity
C4J88_RS08655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J88_RS08690	COG0628	permease
C4J88_RS08705	COG0284	orotidine-5'-phosphate decarboxylase activity
C4J88_RS08710	COG2130	NADP-dependent
C4J88_RS08725	COG0840	transmembrane signaling receptor activity
C4J88_RS08730	COG2267	carboxylic ester hydrolase activity
C4J88_RS08765	COG4948	Mandelate Racemase Muconate Lactonizing
C4J88_RS08780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J88_RS08795	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS08805	COG0625	glutathione transferase activity
C4J88_RS08810	COG1131	(ABC) transporter
C4J88_RS08815	COG0842	Transport permease protein
C4J88_RS08840	COG2076	Multidrug Resistance protein
C4J88_RS08845	COG0385	Bile acid
C4J88_RS08850	COG2974	May be involved in recombination
C4J88_RS08880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J88_RS08885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J88_RS08910	COG2010	Cytochrome c
C4J88_RS08915	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J88_RS08935	COG2200	EAL domain
C4J88_RS08950	COG3842	ATPase activity
C4J88_RS08985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4J88_RS08990	COG1121	(ABC) transporter
C4J88_RS09020	COG1509	lysine 2,3-aminomutase activity
C4J88_RS09025	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4J88_RS09055	COG3829	transcription factor binding
C4J88_RS09080	COG5006	permease, DMT superfamily
C4J88_RS09115	COG0768	penicillin binding
C4J88_RS09130	COG0417	DNA replication proofreading
C4J88_RS09150	COG0728	peptidoglycan biosynthetic process
C4J88_RS09190	COG0463	Glycosyl transferase, family 2
C4J88_RS09195	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4J88_RS09195	COG0662	Cupin 2, conserved barrel domain protein
C4J88_RS09200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4J88_RS09210	COG4977	sequence-specific DNA binding
C4J88_RS09220	COG3387	PFAM Glycoside hydrolase 15-related
C4J88_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS09245	COG2223	nitrite transmembrane transporter activity
C4J88_RS09250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J88_RS09270	COG3675	Pfam Lipase (class 3)
C4J88_RS09275	COG0402	S-adenosylhomocysteine deaminase activity
C4J88_RS09280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J88_RS09285	COG0720	synthase
C4J88_RS09315	COG0840	transmembrane signaling receptor activity
C4J88_RS09320	COG2056	Na+-H+ antiporter family
C4J88_RS09330	COG0826	peptidase U32
C4J88_RS09335	COG0628	permease
C4J88_RS09350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J88_RS09355	COG3132	Protein of unknown function, DUF480
C4J88_RS09365	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4J88_RS09370	COG0583	DNA-binding transcription factor activity
C4J88_RS09380	COG1253	flavin adenine dinucleotide binding
C4J88_RS09385	COG0709	Synthesizes selenophosphate from selenide and ATP
C4J88_RS09390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4J88_RS09395	COG0701	Predicted permease
C4J88_RS09405	COG0625	glutathione transferase activity
C4J88_RS09410	COG0384	phenazine biosynthesis protein PhzF
C4J88_RS09415	COG0113	porphobilinogen synthase activity
C4J88_RS09445	COG3209	COG3209 Rhs family protein
C4J88_RS09465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4J88_RS09470	COG0583	DNA-binding transcription factor activity
C4J88_RS09480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4J88_RS09485	COG0517	IMP dehydrogenase activity
C4J88_RS09490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J88_RS09500	COG0477	Major facilitator Superfamily
C4J88_RS09515	COG0174	glutamine synthetase
C4J88_RS09535	COG2814	Major facilitator Superfamily
C4J88_RS09560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4J88_RS09570	COG2197	response regulator
C4J88_RS09575	COG2205	protein histidine kinase activity
C4J88_RS09575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS09585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4J88_RS09590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J88_RS09605	COG2197	response regulator
C4J88_RS09610	COG0322	excinuclease ABC activity
C4J88_RS09625	COG0582	viral genome integration into host DNA
C4J88_RS09790	COG0402	S-adenosylhomocysteine deaminase activity
C4J88_RS09865	COG1132	(ABC) transporter
C4J88_RS09950	COG2003	Belongs to the UPF0758 family
C4J88_RS09970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4J88_RS10025	COG3038	cytochrome b561
C4J88_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS10045	COG0840	transmembrane signaling receptor activity
C4J88_RS10075	COG0028	Belongs to the TPP enzyme family
C4J88_RS10080	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS10105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J88_RS10115	COG2207	Transcriptional regulator
C4J88_RS10135	COG5002	protein histidine kinase activity
C4J88_RS10140	COG0745	RESPONSE REGULATOR receiver
C4J88_RS10160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS10170	COG2814	Major facilitator Superfamily
C4J88_RS10195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J88_RS10210	COG1414	Transcriptional regulator
C4J88_RS10230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J88_RS10290	COG2207	Transcriptional regulator
C4J88_RS10330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J88_RS10380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J88_RS10385	COG0457	Tetratricopeptide repeat
C4J88_RS10385	COG3710	Transcriptional regulator
C4J88_RS10430	COG2197	response regulator
C4J88_RS10440	COG2197	response regulator
C4J88_RS10445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS10445	COG2205	protein histidine kinase activity
C4J88_RS10465	COG3121	Chaperone
C4J88_RS10470	COG3188	usher protein
C4J88_RS10490	COG3121	Chaperone
C4J88_RS10515	COG0531	amino acid
C4J88_RS10525	COG2201	protein-glutamate methylesterase activity
C4J88_RS10530	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C4J88_RS10540	COG0835	chemotaxis
C4J88_RS10560	COG0745	RESPONSE REGULATOR receiver
C4J88_RS10570	COG1414	Transcriptional regulator
C4J88_RS10575	COG4948	Mandelate Racemase Muconate Lactonizing
C4J88_RS10580	COG1063	alcohol dehydrogenase
C4J88_RS10585	COG2271	Major facilitator Superfamily
C4J88_RS10590	COG0246	Mannitol dehydrogenase
C4J88_RS10595	COG1312	Catalyzes the dehydration of D-mannonate
C4J88_RS10625	COG1335	isochorismatase
C4J88_RS10640	COG0583	DNA-binding transcription factor activity
C4J88_RS10655	COG0583	DNA-binding transcription factor activity
C4J88_RS10675	COG3546	catalase activity
C4J88_RS10680	COG3685	Protein conserved in bacteria
C4J88_RS10685	COG0784	Response regulator, receiver
C4J88_RS10685	COG4191	Histidine kinase
C4J88_RS10690	COG0109	protoheme IX farnesyltransferase activity
C4J88_RS10700	COG1845	cytochrome c oxidase, subunit III
C4J88_RS10710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J88_RS10755	COG3729	General stress protein
C4J88_RS10760	COG2203	Gaf domain
C4J88_RS10760	COG3706	GGDEF domain
C4J88_RS10760	COG4251	negative regulation of phosphorylation
C4J88_RS10760	COG5001	Diguanylate cyclase
C4J88_RS10780	COG2323	membrane
C4J88_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS10820	COG1058	Belongs to the CinA family
C4J88_RS10820	COG1546	Belongs to the CinA family
C4J88_RS10845	COG2080	2 iron, 2 sulfur cluster binding
C4J88_RS10850	COG0583	DNA-binding transcription factor activity
C4J88_RS10860	COG4948	Mandelate Racemase Muconate Lactonizing
C4J88_RS10880	COG0019	diaminopimelate decarboxylase activity
C4J88_RS10885	COG1609	Transcriptional regulator
C4J88_RS10895	COG1175	transmembrane transport
C4J88_RS10900	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J88_RS10905	COG3842	ATPase activity
C4J88_RS10910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4J88_RS10920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J88_RS10940	COG2194	sulfuric ester hydrolase activity
C4J88_RS10945	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4J88_RS10950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4J88_RS10955	COG0561	phosphatase activity
C4J88_RS11040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4J88_RS11050	COG2233	PERMEase
C4J88_RS11070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J88_RS11080	COG1609	Transcriptional regulator
C4J88_RS11120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS11125	COG0745	RESPONSE REGULATOR receiver
C4J88_RS11130	COG2205	protein histidine kinase activity
C4J88_RS11140	COG0730	response to heat
C4J88_RS11145	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS11150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J88_RS11155	COG0024	Methionine aminopeptidase
C4J88_RS11180	COG1070	Carbohydrate kinase
C4J88_RS11200	COG1175	transmembrane transport
C4J88_RS11255	COG1538	Outer membrane efflux protein
C4J88_RS11260	COG4214	carbohydrate transport
C4J88_RS11265	COG1129	ABC transporter
C4J88_RS11270	COG4213	ABC transporter substrate-binding protein
C4J88_RS11280	COG2115	Belongs to the xylose isomerase family
C4J88_RS11285	COG2207	Transcriptional regulator
C4J88_RS11285	COG1609	Transcriptional regulator
C4J88_RS11300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J88_RS11310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J88_RS11315	COG3842	ATPase activity
C4J88_RS11325	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J88_RS11330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4J88_RS11335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J88_RS11345	COG0477	Major facilitator Superfamily
C4J88_RS11355	COG2186	Transcriptional regulator
C4J88_RS11360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J88_RS11370	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS11375	COG2267	carboxylic ester hydrolase activity
C4J88_RS11385	COG0840	transmembrane signaling receptor activity
C4J88_RS11390	COG3781	membrane
C4J88_RS11405	COG0640	Transcriptional regulator
C4J88_RS11410	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS11430	COG1609	Transcriptional regulator
C4J88_RS11450	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS11460	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS11465	COG1129	ABC transporter
C4J88_RS11470	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS11485	COG2207	Transcriptional regulator
C4J88_RS11495	COG0625	glutathione transferase activity
C4J88_RS11510	COG0673	inositol 2-dehydrogenase activity
C4J88_RS11545	COG1968	undecaprenyl-diphosphatase activity
C4J88_RS11560	COG1309	transcriptional regulator
C4J88_RS11570	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS11575	COG3321	synthase
C4J88_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS11575	COG0604	alcohol dehydrogenase
C4J88_RS11600	COG1064	alcohol dehydrogenase
C4J88_RS11620	COG0318	PFAM AMP-dependent synthetase and ligase
C4J88_RS11650	COG0475	glutathione-regulated potassium exporter activity
C4J88_RS11650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J88_RS11730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4J88_RS11755	COG1177	transmembrane transport
C4J88_RS11760	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J88_RS11765	COG3842	ATPase activity
C4J88_RS11770	COG1414	Transcriptional regulator
C4J88_RS11780	COG0534	Mate efflux family protein
C4J88_RS11865	COG1741	Belongs to the pirin family
C4J88_RS11885	COG4977	sequence-specific DNA binding
C4J88_RS11885	COG1917	Cupin 2, conserved barrel domain protein
C4J88_RS11900	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C4J88_RS11905	COG1335	isochorismatase
C4J88_RS11910	COG0583	DNA-binding transcription factor activity
C4J88_RS11920	COG5002	protein histidine kinase activity
C4J88_RS11920	COG5001	Diguanylate cyclase
C4J88_RS11920	COG3447	MASE1 domain protein
C4J88_RS11930	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C4J88_RS11950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J88_RS11955	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS11960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J88_RS11970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J88_RS11980	COG0583	DNA-binding transcription factor activity
C4J88_RS12010	COG2264	protein methyltransferase activity
C4J88_RS12020	COG5383	Protein conserved in bacteria
C4J88_RS12040	COG0616	signal peptide processing
C4J88_RS12050	COG2376	Dihydroxyacetone kinase
C4J88_RS12055	COG1063	alcohol dehydrogenase
C4J88_RS12060	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS12065	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS12070	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS12075	COG1129	ABC transporter
C4J88_RS12080	COG0698	ribose 5-phosphate isomerase
C4J88_RS12095	COG1253	flavin adenine dinucleotide binding
C4J88_RS12115	COG0765	amino acid transport
C4J88_RS12120	COG0765	amino acid transport
C4J88_RS12150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J88_RS12160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J88_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS12170	COG2610	gluconate transmembrane transporter activity
C4J88_RS12175	COG3340	Belongs to the peptidase S51 family
C4J88_RS12180	COG3829	transcription factor binding
C4J88_RS12180	COG3290	protein histidine kinase activity
C4J88_RS12185	COG4172	Belongs to the ABC transporter superfamily
C4J88_RS12190	COG4239	(ABC) transporter, permease
C4J88_RS12195	COG4174	ABC transporter (Permease)
C4J88_RS12200	COG4166	transmembrane transport
C4J88_RS12205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J88_RS12215	COG0656	L-ascorbic acid biosynthetic process
C4J88_RS12260	COG2204	response regulator
C4J88_RS12300	COG0515	serine threonine protein kinase
C4J88_RS12315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4J88_RS12345	COG3239	Fatty acid desaturase
C4J88_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS12380	COG0183	Belongs to the thiolase family
C4J88_RS12385	COG0318	PFAM AMP-dependent synthetase and ligase
C4J88_RS12390	COG0673	inositol 2-dehydrogenase activity
C4J88_RS12420	COG2706	6-phosphogluconolactonase activity
C4J88_RS12440	COG0420	3'-5' exonuclease activity
C4J88_RS12480	COG0714	Associated with various cellular activities
C4J88_RS12495	COG2186	Transcriptional regulator
C4J88_RS12510	COG0519	Catalyzes the synthesis of GMP from XMP
C4J88_RS12550	COG2205	protein histidine kinase activity
C4J88_RS12555	COG0745	RESPONSE REGULATOR receiver
C4J88_RS12575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J88_RS12585	COG3718	enzyme involved in inositol metabolism
C4J88_RS12600	COG0673	inositol 2-dehydrogenase activity
C4J88_RS12610	COG0673	inositol 2-dehydrogenase activity
C4J88_RS12620	COG1129	ABC transporter
C4J88_RS12625	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS12685	COG0673	inositol 2-dehydrogenase activity
C4J88_RS12705	COG4172	Belongs to the ABC transporter superfamily
C4J88_RS12710	COG4239	(ABC) transporter, permease
C4J88_RS12715	COG4174	ABC transporter (Permease)
C4J88_RS12720	COG4166	transmembrane transport
C4J88_RS12725	COG4166	transmembrane transport
C4J88_RS12730	COG0741	lytic transglycosylase activity
C4J88_RS12730	COG1388	LysM domain
C4J88_RS12735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4J88_RS12745	COG0328	RNA-DNA hybrid ribonuclease activity
C4J88_RS12750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J88_RS12755	COG0840	transmembrane signaling receptor activity
C4J88_RS12760	COG1968	undecaprenyl-diphosphatase activity
C4J88_RS12780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J88_RS12795	COG0488	(ABC) transporter
C4J88_RS12850	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C4J88_RS12860	COG2133	pyrroloquinoline quinone binding
C4J88_RS12875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J88_RS12880	COG2822	iron ion transport
C4J88_RS12890	COG2822	iron ion transport
C4J88_RS12895	COG0672	)-iron permease
C4J88_RS12900	COG2207	Transcriptional regulator
C4J88_RS12935	COG2204	response regulator
C4J88_RS12940	COG0784	Response regulator, receiver
C4J88_RS12940	COG2205	protein histidine kinase activity
C4J88_RS12945	COG2197	response regulator
C4J88_RS12985	COG1538	Outer membrane efflux protein
C4J88_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS13100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J88_RS13105	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4J88_RS13110	COG1522	sequence-specific DNA binding
C4J88_RS13120	COG1301	dicarboxylic acid transport
C4J88_RS13125	COG0583	DNA-binding transcription factor activity
C4J88_RS13130	COG1309	transcriptional regulator
C4J88_RS13135	COG1309	transcriptional regulator
C4J88_RS13140	COG1309	transcriptional regulator
C4J88_RS13145	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS13150	COG4221	oxidoreductase activity
C4J88_RS13155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4J88_RS13190	COG0697	spore germination
C4J88_RS13205	COG1335	isochorismatase
C4J88_RS13210	COG0640	Transcriptional regulator
C4J88_RS13225	COG1132	(ABC) transporter
C4J88_RS13250	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS13260	COG0583	DNA-binding transcription factor activity
C4J88_RS13310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4J88_RS13320	COG0747	negative chemotaxis
C4J88_RS13335	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS13350	COG3321	synthase
C4J88_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS13350	COG0604	alcohol dehydrogenase
C4J88_RS13375	COG0210	DNA helicase
C4J88_RS13420	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J88_RS13435	COG0513	Belongs to the DEAD box helicase family
C4J88_RS13445	COG2308	Evidence 4 Homologs of previously reported genes of
C4J88_RS13475	COG0784	Response regulator, receiver
C4J88_RS13480	COG2205	protein histidine kinase activity
C4J88_RS13480	COG2202	Pas domain
C4J88_RS13495	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS13500	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS13505	COG1609	Transcriptional regulator
C4J88_RS13510	COG1070	Carbohydrate kinase
C4J88_RS13515	COG1522	sequence-specific DNA binding
C4J88_RS13525	COG0826	peptidase U32
C4J88_RS13535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J88_RS13545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4J88_RS13565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J88_RS13585	COG0596	Alpha beta hydrolase
C4J88_RS13590	COG0596	Alpha beta hydrolase
C4J88_RS13605	COG0640	Transcriptional regulator
C4J88_RS13615	COG0583	DNA-binding transcription factor activity
C4J88_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS13625	COG1942	4-Oxalocrotonate Tautomerase
C4J88_RS13675	COG3920	Histidine kinase
C4J88_RS13675	COG2202	Pas domain
C4J88_RS13705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4J88_RS13710	COG1349	DNA-binding transcription factor activity
C4J88_RS13720	COG0738	Major facilitator superfamily
C4J88_RS13735	COG2814	Major facilitator Superfamily
C4J88_RS13740	COG4974	Belongs to the 'phage' integrase family
C4J88_RS13750	COG0463	Glycosyl transferase, family 2
C4J88_RS13755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4J88_RS13755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J88_RS13760	COG0726	polysaccharide deacetylase
C4J88_RS13765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J88_RS13770	COG2076	Multidrug Resistance protein
C4J88_RS13775	COG2076	Multidrug Resistance protein
C4J88_RS13800	COG1024	Enoyl-CoA hydratase
C4J88_RS13805	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS13810	COG1024	Enoyl-CoA hydratase
C4J88_RS13815	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS13830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J88_RS13840	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4J88_RS13855	COG0784	Response regulator, receiver
C4J88_RS13855	COG2205	protein histidine kinase activity
C4J88_RS13855	COG5002	protein histidine kinase activity
C4J88_RS13865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J88_RS13870	COG2205	protein histidine kinase activity
C4J88_RS13870	COG2198	Histidine kinase
C4J88_RS13870	COG0784	Response regulator, receiver
C4J88_RS13895	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4J88_RS13900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C4J88_RS13910	COG1794	racemase activity, acting on amino acids and derivatives
C4J88_RS13915	COG1247	-acetyltransferase
C4J88_RS13920	COG1929	Belongs to the glycerate kinase type-1 family
C4J88_RS13925	COG3835	regulator
C4J88_RS13930	COG2271	Major facilitator Superfamily
C4J88_RS13940	COG0583	DNA-binding transcription factor activity
C4J88_RS13945	COG0667	Aldo Keto reductase
C4J88_RS13960	COG2200	EAL domain
C4J88_RS14025	COG3258	Cytochrome c
C4J88_RS14030	COG2863	cytochrome
C4J88_RS14045	COG3145	DNA-N1-methyladenine dioxygenase activity
C4J88_RS14065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4J88_RS14075	COG0488	(ABC) transporter
C4J88_RS14095	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4J88_RS14185	COG0531	amino acid
C4J88_RS14190	COG3938	Belongs to the proline racemase family
C4J88_RS14205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS14235	COG2814	Major facilitator Superfamily
C4J88_RS14280	COG1566	PFAM secretion protein HlyD family protein
C4J88_RS14285	COG2814	Major facilitator Superfamily
C4J88_RS14295	COG0656	L-ascorbic acid biosynthetic process
C4J88_RS14330	COG3210	domain, Protein
C4J88_RS14365	COG0583	DNA-binding transcription factor activity
C4J88_RS14385	COG3773	Cell wall hydrolase
C4J88_RS14385	COG3409	Peptidoglycan-binding domain 1 protein
C4J88_RS14640	COG0305	Participates in initiation and elongation during chromosome replication
C4J88_RS14670	COG2932	Transcriptional regulator
C4J88_RS14825	COG2366	antibiotic biosynthetic process
C4J88_RS14840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J88_RS14845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J88_RS14850	COG1116	anion transmembrane transporter activity
C4J88_RS14850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J88_RS14870	COG0583	DNA-binding transcription factor activity
C4J88_RS14875	COG0667	Aldo Keto reductase
C4J88_RS14880	COG0840	transmembrane signaling receptor activity
C4J88_RS14890	COG0596	Alpha beta hydrolase
C4J88_RS14895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J88_RS14905	COG0297	glycogen (starch) synthase activity
C4J88_RS14910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J88_RS14915	COG1640	4-alpha-glucanotransferase
C4J88_RS14960	COG0840	transmembrane signaling receptor activity
C4J88_RS14970	COG5002	protein histidine kinase activity
C4J88_RS15065	COG2814	Major facilitator Superfamily
C4J88_RS15080	COG0626	cystathionine gamma-synthase activity
C4J88_RS15090	COG1944	ATP diphosphatase activity
C4J88_RS15095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J88_RS15095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4J88_RS15100	COG1335	isochorismatase
C4J88_RS15130	COG2271	Major facilitator Superfamily
C4J88_RS15135	COG0519	Catalyzes the synthesis of GMP from XMP
C4J88_RS15150	COG2207	Transcriptional regulator
C4J88_RS15165	COG2207	Transcriptional regulator
C4J88_RS15170	COG2223	nitrite transmembrane transporter activity
C4J88_RS15180	COG0154	amidase activity
C4J88_RS15190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J88_RS15195	COG0697	spore germination
C4J88_RS15215	COG2205	protein histidine kinase activity
C4J88_RS15220	COG0745	RESPONSE REGULATOR receiver
C4J88_RS15235	COG0589	response to stress
C4J88_RS15250	COG0814	amino acid
C4J88_RS15255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J88_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS15280	COG0308	aminopeptidase N
C4J88_RS15290	COG3139	Protein of unknown function (DUF1315)
C4J88_RS15300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J88_RS15305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4J88_RS15335	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C4J88_RS15360	COG0316	Belongs to the HesB IscA family
C4J88_RS15360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4J88_RS15385	COG0028	Belongs to the TPP enzyme family
C4J88_RS15390	COG0431	NADPH-dependent FMN reductase
C4J88_RS15410	COG0456	acetyltransferase
C4J88_RS15430	COG0708	Exodeoxyribonuclease III
C4J88_RS15440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4J88_RS15460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J88_RS15465	COG1116	anion transmembrane transporter activity
C4J88_RS15470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J88_RS15495	COG2816	NAD+ diphosphatase activity
C4J88_RS15500	COG1024	Enoyl-CoA hydratase
C4J88_RS15505	COG3318	Belongs to the UPF0149 family
C4J88_RS15505	COG3012	SEC-C Motif Domain Protein
C4J88_RS15510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4J88_RS15520	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4J88_RS15540	COG0784	Response regulator, receiver
C4J88_RS15540	COG4191	Histidine kinase
C4J88_RS15545	COG3706	GGDEF domain
C4J88_RS15550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4J88_RS15555	COG0366	Alpha amylase catalytic
C4J88_RS15565	COG1285	pathogenesis
C4J88_RS15575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J88_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS15585	COG2066	Belongs to the glutaminase family
C4J88_RS15600	COG0784	Response regulator, receiver
C4J88_RS15600	COG4191	Histidine kinase
C4J88_RS15605	COG0587	DNA-directed DNA polymerase activity
C4J88_RS15620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4J88_RS15625	COG0494	nUDIX hydrolase
C4J88_RS15635	COG1304	FMN binding
C4J88_RS15660	COG0693	protein deglycase activity
C4J88_RS15675	COG1999	signal sequence binding
C4J88_RS15695	COG2072	flavoprotein involved in K transport
C4J88_RS15715	COG0583	DNA-binding transcription factor activity
C4J88_RS15720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4J88_RS15725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4J88_RS15735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J88_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS15760	COG0583	DNA-binding transcription factor activity
C4J88_RS15770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4J88_RS15785	COG2814	Major facilitator Superfamily
C4J88_RS15790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS15795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4J88_RS15800	COG3209	COG3209 Rhs family protein
C4J88_RS15830	COG3706	GGDEF domain
C4J88_RS15835	COG1280	lysine exporter protein (LysE YggA)
C4J88_RS15840	COG2186	Transcriptional regulator
C4J88_RS15845	COG1522	sequence-specific DNA binding
C4J88_RS15855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4J88_RS15860	COG2814	Major facilitator Superfamily
C4J88_RS15875	COG3300	MHYT domain
C4J88_RS15875	COG5001	Diguanylate cyclase
C4J88_RS15890	COG3121	Chaperone
C4J88_RS15900	COG2205	protein histidine kinase activity
C4J88_RS15900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS15905	COG2197	response regulator
C4J88_RS15910	COG3706	GGDEF domain
C4J88_RS15910	COG2203	Gaf domain
C4J88_RS15910	COG4251	negative regulation of phosphorylation
C4J88_RS15910	COG5001	Diguanylate cyclase
C4J88_RS15920	COG2207	Transcriptional regulator
C4J88_RS15930	COG1063	alcohol dehydrogenase
C4J88_RS15935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4J88_RS15970	COG0395	ABC-type sugar transport system, permease component
C4J88_RS15980	COG3842	ATPase activity
C4J88_RS15985	COG3842	ATPase activity
C4J88_RS15990	COG3284	Transcriptional regulator
C4J88_RS16020	COG2192	nodulation
C4J88_RS16035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C4J88_RS16080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4J88_RS16090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4J88_RS16095	COG2835	tetraacyldisaccharide 4'-kinase activity
C4J88_RS16100	COG1663	tetraacyldisaccharide 4'-kinase activity
C4J88_RS16105	COG0848	biopolymer transport protein
C4J88_RS16110	COG0811	peptide transport
C4J88_RS16115	COG0658	competence protein
C4J88_RS16115	COG2333	competence protein COMEC
C4J88_RS16135	COG5002	protein histidine kinase activity
C4J88_RS16135	COG2205	protein histidine kinase activity
C4J88_RS16135	COG0784	Response regulator, receiver
C4J88_RS16140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4J88_RS16160	COG1393	Belongs to the ArsC family
C4J88_RS16175	COG2818	Glycosylase
C4J88_RS16180	COG0037	tRNA processing
C4J88_RS16190	COG3091	SprT-like family
C4J88_RS16200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J88_RS16220	COG2920	part of a sulfur-relay system
C4J88_RS16230	COG0435	Glutathione S-transferase
C4J88_RS16235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J88_RS16235	COG1648	precorrin-2 dehydrogenase activity
C4J88_RS16240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4J88_RS16245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4J88_RS16250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4J88_RS16255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4J88_RS16260	COG1674	ftsk spoiiie
C4J88_RS16265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4J88_RS16270	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4J88_RS16275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4J88_RS16280	COG0542	response to heat
C4J88_RS16285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4J88_RS16290	COG1278	Cold shock
C4J88_RS16305	COG0583	DNA-binding transcription factor activity
C4J88_RS16320	COG0482	sulfurtransferase activity
C4J88_RS16325	COG2915	High frequency lysogenization protein hflD homolog
C4J88_RS16335	COG2850	peptidyl-arginine hydroxylation
C4J88_RS16340	COG2153	protein acetylation
C4J88_RS16350	COG2224	Isocitrate lyase
C4J88_RS16355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J88_RS16360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J88_RS16365	COG0649	NAD binding
C4J88_RS16365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J88_RS16380	COG1034	ATP synthesis coupled electron transport
C4J88_RS16385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4J88_RS16390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4J88_RS16400	COG0713	ATP synthesis coupled electron transport
C4J88_RS16415	COG1007	ATP synthesis coupled electron transport
C4J88_RS16445	COG2814	Major facilitator Superfamily
C4J88_RS16460	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS16475	COG0577	efflux transmembrane transporter activity
C4J88_RS16475	COG1136	(ABC) transporter
C4J88_RS16480	COG1136	(ABC) transporter
C4J88_RS16480	COG0577	efflux transmembrane transporter activity
C4J88_RS16560	COG2111	Na H antiporter
C4J88_RS16560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4J88_RS16565	COG1006	Multisubunit Na H antiporter MnhC subunit
C4J88_RS16570	COG0651	ATP synthesis coupled electron transport
C4J88_RS16580	COG2212	antiporter activity
C4J88_RS16585	COG1320	monovalent cation:proton antiporter activity
C4J88_RS16600	COG1733	regulation of RNA biosynthetic process
C4J88_RS16610	COG0215	cysteine-tRNA ligase activity
C4J88_RS16615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J88_RS16625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4J88_RS16630	COG2814	Major facilitator Superfamily
C4J88_RS16635	COG1566	PFAM secretion protein HlyD family protein
C4J88_RS16645	COG1846	Transcriptional regulator
C4J88_RS16650	COG2911	Protein conserved in bacteria
C4J88_RS16655	COG0729	surface antigen
C4J88_RS16665	COG0708	Exodeoxyribonuclease III
C4J88_RS16670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4J88_RS16685	COG0789	Transcriptional regulator
C4J88_RS16700	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS16705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4J88_RS16730	COG2866	Carboxypeptidase
C4J88_RS16735	COG3038	cytochrome b561
C4J88_RS16755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4J88_RS16765	COG0217	transcriptional regulatory protein
C4J88_RS16770	COG0583	DNA-binding transcription factor activity
C4J88_RS16775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4J88_RS16780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J88_RS16785	COG3038	cytochrome b561
C4J88_RS16795	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS16795	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J88_RS16815	COG1846	Transcriptional regulator
C4J88_RS16820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4J88_RS16830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J88_RS16835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J88_RS16840	COG0776	regulation of translation
C4J88_RS16845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4J88_RS16850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4J88_RS16855	COG0740	serine-type endopeptidase activity
C4J88_RS16860	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4J88_RS16885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4J88_RS16890	COG1686	Belongs to the peptidase S11 family
C4J88_RS16895	COG3385	transposase activity
C4J88_RS16930	COG1953	Uracil, thiamine, allantoin
C4J88_RS16940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J88_RS16940	COG0493	'glutamate synthase
C4J88_RS16950	COG1309	transcriptional regulator
C4J88_RS16970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J88_RS16980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4J88_RS17020	COG0640	Transcriptional regulator
C4J88_RS17030	COG1522	sequence-specific DNA binding
C4J88_RS17035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4J88_RS17040	COG0022	dehydrogenase e1 component
C4J88_RS17050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4J88_RS17055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J88_RS17090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4J88_RS17095	COG0577	efflux transmembrane transporter activity
C4J88_RS17095	COG1136	(ABC) transporter
C4J88_RS17110	COG2186	Transcriptional regulator
C4J88_RS17155	COG1609	Transcriptional regulator
C4J88_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS17165	COG1070	Carbohydrate kinase
C4J88_RS17170	COG1063	alcohol dehydrogenase
C4J88_RS17175	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS17185	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS17215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J88_RS17220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4J88_RS17245	COG0583	DNA-binding transcription factor activity
C4J88_RS17250	COG0583	DNA-binding transcription factor activity
C4J88_RS17255	COG0625	glutathione transferase activity
C4J88_RS17260	COG0667	Aldo Keto reductase
C4J88_RS17290	COG1231	oxidoreductase activity
C4J88_RS17295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS17300	COG1126	abc transporter atp-binding protein
C4J88_RS17315	COG1450	Type ii and iii secretion system protein
C4J88_RS17330	COG3166	PFAM Fimbrial assembly family protein
C4J88_RS17335	COG3156	type II secretion system protein K
C4J88_RS17350	COG2165	general secretion pathway protein
C4J88_RS17355	COG2165	general secretion pathway protein
C4J88_RS17360	COG1459	type II secretion system
C4J88_RS17365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J88_RS17435	COG0776	regulation of translation
C4J88_RS17440	COG0072	phenylalanine-tRNA ligase activity
C4J88_RS17445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J88_RS17450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4J88_RS17455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4J88_RS17460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4J88_RS17465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4J88_RS17475	COG1278	Cold shock
C4J88_RS17500	COG1869	D-ribose catabolic process
C4J88_RS17505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J88_RS17510	COG1609	Transcriptional regulator
C4J88_RS17515	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS17520	COG1129	ABC transporter
C4J88_RS17525	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS17550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J88_RS17560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J88_RS17575	COG5002	protein histidine kinase activity
C4J88_RS17605	COG0483	inositol monophosphate 1-phosphatase activity
C4J88_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS17645	COG0436	Aminotransferase
C4J88_RS17660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J88_RS17680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS17715	COG1286	toxin biosynthetic process
C4J88_RS17720	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4J88_RS17725	COG0285	dihydrofolate synthase activity
C4J88_RS17730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4J88_RS17735	COG0135	phosphoribosylanthranilate isomerase activity
C4J88_RS17760	COG0473	3-isopropylmalate dehydrogenase activity
C4J88_RS17765	COG2226	methyltransferase
C4J88_RS17770	COG0066	3-isopropylmalate dehydratase activity
C4J88_RS17775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J88_RS17800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4J88_RS17810	COG0596	Alpha beta hydrolase
C4J88_RS17840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J88_RS17845	COG0556	nucleotide-excision repair
C4J88_RS17860	COG0583	DNA-binding transcription factor activity
C4J88_RS17865	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS17880	COG3591	Belongs to the peptidase S1B family
C4J88_RS17880	COG1864	DNA RNA non-specific endonuclease
C4J88_RS17885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4J88_RS17890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J88_RS17895	COG1120	ATPase activity
C4J88_RS17910	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C4J88_RS17955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4J88_RS17970	COG0251	oxidation-reduction process
C4J88_RS18000	COG2814	Major facilitator Superfamily
C4J88_RS18005	COG1942	4-Oxalocrotonate Tautomerase
C4J88_RS18020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4J88_RS18055	COG3011	Protein conserved in bacteria
C4J88_RS18095	COG0477	Major facilitator Superfamily
C4J88_RS18130	COG0840	transmembrane signaling receptor activity
C4J88_RS18135	COG2384	SAM-dependent methyltransferase
C4J88_RS18140	COG2186	Transcriptional regulator
C4J88_RS18155	COG3385	transposase activity
C4J88_RS18180	COG2391	methyltransferase activity
C4J88_RS18190	COG1230	cation diffusion facilitator family transporter
C4J88_RS18200	COG0583	DNA-binding transcription factor activity
C4J88_RS18205	COG1304	FMN binding
C4J88_RS18220	COG5001	Diguanylate cyclase
C4J88_RS18220	COG5002	protein histidine kinase activity
C4J88_RS18235	COG1054	Belongs to the UPF0176 family
C4J88_RS18265	COG0271	Belongs to the BolA IbaG family
C4J88_RS18275	COG0114	fumarate hydratase activity
C4J88_RS18285	COG0697	spore germination
C4J88_RS18300	COG3539	Fimbrial protein
C4J88_RS18305	COG3539	Fimbrial protein
C4J88_RS18320	COG3121	Chaperone
C4J88_RS18325	COG3188	usher protein
C4J88_RS18345	COG0583	DNA-binding transcription factor activity
C4J88_RS18350	COG0183	Belongs to the thiolase family
C4J88_RS18355	COG2326	polyphosphate kinase activity
C4J88_RS18360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS18360	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4J88_RS18365	COG0367	asparagine synthase
C4J88_RS18370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4J88_RS18370	COG0189	ligase activity
C4J88_RS18380	COG3089	Belongs to the UPF0270 family
C4J88_RS18385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J88_RS18400	COG1368	sulfuric ester hydrolase activity
C4J88_RS18425	COG2197	response regulator
C4J88_RS18430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4J88_RS18435	COG2814	Major facilitator Superfamily
C4J88_RS18440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4J88_RS18445	COG1073	alpha beta
C4J88_RS18470	COG2840	Smr protein MutS2
C4J88_RS18475	COG0302	gtp cyclohydrolase
C4J88_RS18495	COG2851	Citrate transporter
C4J88_RS18500	COG0583	DNA-binding transcription factor activity
C4J88_RS18505	COG0625	glutathione transferase activity
C4J88_RS18510	COG2252	PERMEase
C4J88_RS18540	COG4266	Belongs to the allantoicase family
C4J88_RS18545	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4J88_RS18555	COG2233	PERMEase
C4J88_RS18570	COG1560	Kdo2-lipid A biosynthetic process
C4J88_RS18575	COG0850	regulation of cytokinetic process
C4J88_RS18580	COG2894	cell division
C4J88_RS18585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4J88_RS18590	COG0564	pseudouridine synthase activity
C4J88_RS18595	COG1362	aminopeptidase activity
C4J88_RS18600	COG0668	transmembrane transport
C4J88_RS18635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4J88_RS18670	COG1309	transcriptional regulator
C4J88_RS18680	COG3123	guanosine phosphorylase activity
C4J88_RS18685	COG0633	Ferredoxin
C4J88_RS18685	COG3217	Mosc domain protein beta barrel domain protein
C4J88_RS18700	COG3851	Histidine kinase
C4J88_RS18705	COG2197	response regulator
C4J88_RS18710	COG1597	lipid kinase activity
C4J88_RS18730	COG1192	Involved in chromosome partitioning
C4J88_RS18735	COG1360	Flagellar Motor Protein
C4J88_RS18740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4J88_RS18745	COG2201	protein-glutamate methylesterase activity
C4J88_RS18750	COG2198	Histidine kinase
C4J88_RS18750	COG0643	Histidine kinase
C4J88_RS18750	COG0784	Response regulator, receiver
C4J88_RS18755	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4J88_RS18880	COG1677	Flagellar hook-basal body complex protein FliE
C4J88_RS18910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4J88_RS18925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4J88_RS18945	COG1706	bacterial-type flagellum-dependent cell motility
C4J88_RS18950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4J88_RS18960	COG4787	bacterial-type flagellum-dependent cell motility
C4J88_RS18975	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4J88_RS18990	COG2207	Transcriptional regulator
C4J88_RS19005	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4J88_RS19010	COG1846	Transcriptional regulator
C4J88_RS19015	COG0514	ATP-dependent DNA helicase (RecQ)
C4J88_RS19025	COG2832	Protein of unknown function (DUF454)
C4J88_RS19030	COG2198	Histidine kinase
C4J88_RS19030	COG2205	protein histidine kinase activity
C4J88_RS19030	COG0784	Response regulator, receiver
C4J88_RS19085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4J88_RS19090	COG0406	alpha-ribazole phosphatase activity
C4J88_RS19095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4J88_RS19105	COG1492	cobalamin metabolic process
C4J88_RS19115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4J88_RS19120	COG0778	Nitroreductase
C4J88_RS19125	COG1797	cobyrinic acid a,c-diamide synthase activity
C4J88_RS19140	COG0791	NLP P60 protein
C4J88_RS19145	COG0791	NLP P60 protein
C4J88_RS19150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4J88_RS19155	COG0628	permease
C4J88_RS19165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4J88_RS19170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4J88_RS19185	COG4264	IucA IucC family
C4J88_RS19190	COG2814	Major facilitator Superfamily
C4J88_RS19200	COG3122	Protein conserved in bacteria
C4J88_RS19205	COG3956	TIGRFAM MazG family protein
C4J88_RS19210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J88_RS19260	COG0583	DNA-binding transcription factor activity
C4J88_RS19270	COG1953	Uracil, thiamine, allantoin
C4J88_RS19280	COG2996	Protein conserved in bacteria
C4J88_RS19310	COG0513	Belongs to the DEAD box helicase family
C4J88_RS19345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4J88_RS19370	COG1132	(ABC) transporter
C4J88_RS19385	COG2188	Transcriptional regulator
C4J88_RS19395	COG1595	DNA-templated transcription, initiation
C4J88_RS19405	COG1643	Atp-dependent helicase
C4J88_RS19415	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4J88_RS19425	COG0840	transmembrane signaling receptor activity
C4J88_RS19435	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J88_RS19450	COG2010	Cytochrome c
C4J88_RS19455	COG3278	Belongs to the heme-copper respiratory oxidase family
C4J88_RS19470	COG2010	Cytochrome c
C4J88_RS19475	COG0348	domain, Protein
C4J88_RS19485	COG2217	Heavy metal translocating P-type atpase
C4J88_RS19510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4J88_RS19515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J88_RS19520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4J88_RS19525	COG2130	NADP-dependent
C4J88_RS19530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4J88_RS19535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4J88_RS19565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4J88_RS19570	COG3115	cell septum assembly
C4J88_RS19590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J88_RS19600	COG0402	S-adenosylhomocysteine deaminase activity
C4J88_RS19605	COG2207	Transcriptional regulator
C4J88_RS19610	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS19615	COG3268	Saccharopine dehydrogenase
C4J88_RS19620	COG2207	Transcriptional regulator
C4J88_RS19625	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS19630	COG1802	Transcriptional regulator
C4J88_RS19635	COG3135	benzoate transporter
C4J88_RS19640	COG3171	Protein conserved in bacteria
C4J88_RS19655	COG0116	Belongs to the methyltransferase superfamily
C4J88_RS19655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J88_RS19660	COG3130	regulation of translation
C4J88_RS19665	COG0167	dihydroorotate dehydrogenase activity
C4J88_RS19680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4J88_RS19690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J88_RS19690	COG1116	anion transmembrane transporter activity
C4J88_RS19695	COG3707	response regulator
C4J88_RS19700	COG2223	nitrite transmembrane transporter activity
C4J88_RS19710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4J88_RS19715	COG2146	nitrite reductase [NAD(P)H] activity
C4J88_RS19720	COG0243	molybdopterin cofactor binding
C4J88_RS19725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4J88_RS19730	COG2885	chlorophyll binding
C4J88_RS19730	COG3047	cAMP biosynthetic process
C4J88_RS19755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4J88_RS19770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4J88_RS19775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J88_RS19790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4J88_RS19795	COG1045	serine acetyltransferase
C4J88_RS19800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J88_RS19815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4J88_RS19820	COG0372	Belongs to the citrate synthase family
C4J88_RS19830	COG1802	Transcriptional regulator
C4J88_RS19835	COG0189	ligase activity
C4J88_RS19835	COG4067	protein conserved in archaea
C4J88_RS19845	COG0189	ligase activity
C4J88_RS19850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J88_RS19865	COG0560	Phosphoserine phosphatase
C4J88_RS19875	COG1953	Uracil, thiamine, allantoin
C4J88_RS19885	COG0583	DNA-binding transcription factor activity
C4J88_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS19895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4J88_RS19935	COG3706	GGDEF domain
C4J88_RS19935	COG5001	Diguanylate cyclase
C4J88_RS19935	COG2203	Gaf domain
C4J88_RS19935	COG4251	negative regulation of phosphorylation
C4J88_RS19955	COG0598	Magnesium transport protein CorA
C4J88_RS19960	COG0519	Catalyzes the synthesis of GMP from XMP
C4J88_RS19960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J88_RS19965	COG1024	Enoyl-CoA hydratase
C4J88_RS19965	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J88_RS19970	COG0183	Belongs to the thiolase family
C4J88_RS19980	COG1305	Transglutaminase-like
C4J88_RS19990	COG2308	Evidence 4 Homologs of previously reported genes of
C4J88_RS20020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J88_RS20025	COG3047	cAMP biosynthetic process
C4J88_RS20025	COG2885	chlorophyll binding
C4J88_RS20055	COG2207	Transcriptional regulator
C4J88_RS20060	COG1064	alcohol dehydrogenase
C4J88_RS20065	COG1414	Transcriptional regulator
C4J88_RS20070	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4J88_RS20075	COG1129	ABC transporter
C4J88_RS20080	COG1879	ABC-type sugar transport system periplasmic component
C4J88_RS20085	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS20110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4J88_RS20120	COG1397	ADP-ribosylglycohydrolase
C4J88_RS20125	COG2188	Transcriptional regulator
C4J88_RS20140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J88_RS20150	COG0084	hydrolase, TatD family'
C4J88_RS20160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4J88_RS20165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4J88_RS20170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4J88_RS20175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4J88_RS20180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4J88_RS20195	COG0416	fatty acid biosynthetic process
C4J88_RS20200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4J88_RS20205	COG1399	metal-binding, possibly nucleic acid-binding protein
C4J88_RS20210	COG0424	maF-like protein
C4J88_RS20215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4J88_RS20215	COG0616	signal peptide processing
C4J88_RS20220	COG0546	phosphoglycolate phosphatase activity
C4J88_RS20230	COG1530	ribonuclease E activity
C4J88_RS20235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J88_RS20240	COG3608	succinylglutamate desuccinylase aspartoacylase
C4J88_RS20240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4J88_RS20255	COG1301	dicarboxylic acid transport
C4J88_RS20260	COG4977	sequence-specific DNA binding
C4J88_RS20260	COG1917	Cupin 2, conserved barrel domain protein
C4J88_RS20285	COG2205	protein histidine kinase activity
C4J88_RS20290	COG0745	RESPONSE REGULATOR receiver
C4J88_RS20310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4J88_RS20320	COG1815	bacterial-type flagellum-dependent cell motility
C4J88_RS20325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4J88_RS20330	COG0835	chemotaxis
C4J88_RS20330	COG0784	Response regulator, receiver
C4J88_RS20350	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4J88_RS20355	COG0477	Major facilitator Superfamily
C4J88_RS20410	COG2239	Acts as a magnesium transporter
C4J88_RS20430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4J88_RS20435	COG0527	aspartate kinase activity
C4J88_RS20440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4J88_RS20445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4J88_RS20450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J88_RS20455	COG2988	succinylglutamate desuccinylase activity
C4J88_RS20465	COG3724	N-succinylarginine dihydrolase activity
C4J88_RS20470	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS20485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J88_RS20525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS20535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J88_RS20545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4J88_RS20590	COG0154	amidase activity
C4J88_RS20625	COG0504	CTP synthase activity
C4J88_RS20630	COG2329	Antibiotic biosynthesis monooxygenase
C4J88_RS20640	COG0584	glycerophosphoryl diester phosphodiesterase
C4J88_RS20655	COG0306	phosphate transporter
C4J88_RS20660	COG0583	DNA-binding transcription factor activity
C4J88_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS20675	COG0583	DNA-binding transcription factor activity
C4J88_RS20680	COG4941	Belongs to the sigma-70 factor family
C4J88_RS20685	COG3795	YCII-related domain
C4J88_RS20720	COG0436	Aminotransferase
C4J88_RS20730	COG3265	gluconokinase activity
C4J88_RS20735	COG1609	Transcriptional regulator
C4J88_RS20740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4J88_RS20765	COG2271	Major facilitator Superfamily
C4J88_RS20775	COG0583	DNA-binding transcription factor activity
C4J88_RS20785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J88_RS20795	COG0242	peptide deformylase activity
C4J88_RS20800	COG1295	ribonuclease BN
C4J88_RS20805	COG3237	CsbD-like
C4J88_RS20815	COG0318	PFAM AMP-dependent synthetase and ligase
C4J88_RS20820	COG0318	PFAM AMP-dependent synthetase and ligase
C4J88_RS20830	COG2030	dehydratase
C4J88_RS20840	COG3530	Putative quorum-sensing-regulated virulence factor
C4J88_RS20845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4J88_RS20850	COG0800	Aldolase
C4J88_RS20865	COG1737	Transcriptional regulator
C4J88_RS20870	COG0676	glucose-6-phosphate 1-epimerase activity
C4J88_RS20880	COG3842	ATPase activity
C4J88_RS20885	COG0395	ABC-type sugar transport system, permease component
C4J88_RS20890	COG1175	transmembrane transport
C4J88_RS20895	COG1653	transport
C4J88_RS20910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4J88_RS20915	COG0583	DNA-binding transcription factor activity
C4J88_RS20930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4J88_RS20950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4J88_RS20980	COG1113	amino acid transport
C4J88_RS21000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4J88_RS21010	COG0009	L-threonylcarbamoyladenylate synthase
C4J88_RS21015	COG0613	PHP domain protein
C4J88_RS21020	COG2917	probably involved in intracellular septation
C4J88_RS21025	COG2350	Protein conserved in bacteria
C4J88_RS21035	COG0745	RESPONSE REGULATOR receiver
C4J88_RS21045	COG0642	Histidine kinase
C4J88_RS21050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4J88_RS21090	COG0509	glycine decarboxylation via glycine cleavage system
C4J88_RS21095	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J88_RS21095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4J88_RS21100	COG1760	l-serine dehydratase
C4J88_RS21105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J88_RS21110	COG1278	Cold shock
C4J88_RS21120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4J88_RS21140	COG1538	Outer membrane efflux protein
C4J88_RS21150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J88_RS21160	COG0602	queuosine metabolic process
C4J88_RS21165	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4J88_RS21170	COG2885	chlorophyll binding
C4J88_RS21175	COG0823	Involved in the tonB-independent uptake of proteins
C4J88_RS21195	COG0824	Thioesterase
C4J88_RS21205	COG2255	four-way junction helicase activity
C4J88_RS21210	COG0632	four-way junction helicase activity
C4J88_RS21215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4J88_RS21220	COG0217	transcriptional regulatory protein
C4J88_RS21225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4J88_RS21240	COG0783	Belongs to the Dps family
C4J88_RS21250	COG2900	Belongs to the SlyX family
C4J88_RS21265	COG0668	transmembrane transport
C4J88_RS21270	COG1666	GTP binding
C4J88_RS21280	COG4191	Histidine kinase
C4J88_RS21280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS21285	COG2096	Adenosyltransferase
C4J88_RS21300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4J88_RS21305	COG0653	protein targeting
C4J88_RS21315	COG0433	COG0433 Predicted ATPase
C4J88_RS21325	COG0438	transferase activity, transferring glycosyl groups
C4J88_RS21325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4J88_RS21340	COG0788	formyltetrahydrofolate deformylase activity
C4J88_RS21350	COG2925	Exonuclease
C4J88_RS21375	COG0714	Associated with various cellular activities
C4J88_RS21395	COG0469	pyruvate kinase activity
C4J88_RS21410	COG4191	Histidine kinase
C4J88_RS21420	COG0477	Major facilitator Superfamily
C4J88_RS21440	COG2207	Transcriptional regulator
C4J88_RS21470	COG1595	DNA-templated transcription, initiation
C4J88_RS21480	COG4771	TonB-dependent receptor
C4J88_RS21490	COG2832	Protein of unknown function (DUF454)
C4J88_RS21495	COG0840	transmembrane signaling receptor activity
C4J88_RS21535	COG3642	lipopolysaccharide core region biosynthetic process
C4J88_RS21545	COG0642	Histidine kinase
C4J88_RS21555	COG1368	sulfuric ester hydrolase activity
C4J88_RS21565	COG0459	protein refolding
C4J88_RS21570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4J88_RS21595	COG2211	Major facilitator Superfamily
C4J88_RS21600	COG0442	prolyl-tRNA aminoacylation
C4J88_RS21615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4J88_RS21675	COG4974	Belongs to the 'phage' integrase family
C4J88_RS21685	COG0335	large ribosomal subunit rRNA binding
C4J88_RS21690	COG0336	Belongs to the RNA methyltransferase TrmD family
C4J88_RS21695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4J88_RS21700	COG0228	four-way junction DNA binding
C4J88_RS21705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4J88_RS21715	COG4536	flavin adenine dinucleotide binding
C4J88_RS21720	COG0477	Major facilitator Superfamily
C4J88_RS21730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4J88_RS21755	COG0494	nUDIX hydrolase
C4J88_RS21760	COG2816	NAD+ diphosphatase activity
C4J88_RS21770	COG2188	Transcriptional regulator
C4J88_RS21775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4J88_RS21780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J88_RS21785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4J88_RS21785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4J88_RS21790	COG2190	(PTS) system
C4J88_RS21790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4J88_RS21790	COG1263	PTS System
C4J88_RS21805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4J88_RS21810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4J88_RS21810	COG0047	phosphoribosylformylglycinamidine synthase activity
C4J88_RS21815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4J88_RS21865	COG5314	conjugation
C4J88_RS21890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J88_RS21910	COG0431	NADPH-dependent FMN reductase
C4J88_RS21935	COG0582	viral genome integration into host DNA
C4J88_RS21940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4J88_RS21940	COG0519	Catalyzes the synthesis of GMP from XMP
C4J88_RS21960	COG1570	exodeoxyribonuclease VII activity
C4J88_RS21965	COG0739	heme binding
C4J88_RS21975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4J88_RS21985	COG0436	Aminotransferase
C4J88_RS21990	COG1160	GTP binding
C4J88_RS22005	COG0124	histidyl-tRNA synthetase
C4J88_RS22010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4J88_RS22015	COG1426	Protein conserved in bacteria
C4J88_RS22025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4J88_RS22030	COG0105	UTP biosynthetic process
C4J88_RS22040	COG0633	Ferredoxin
C4J88_RS22045	COG0443	Heat shock 70 kDa protein
C4J88_RS22050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J88_RS22055	COG0316	Belongs to the HesB IscA family
C4J88_RS22065	COG1104	cysteine desulfurase activity
C4J88_RS22090	COG3134	Outer membrane lipoprotein
C4J88_RS22105	COG1862	Preprotein translocase
C4J88_RS22110	COG0343	queuine tRNA-ribosyltransferase activity
C4J88_RS22115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4J88_RS22135	COG1278	Cold shock
C4J88_RS22155	COG0243	molybdopterin cofactor binding
C4J88_RS22195	COG1280	lysine exporter protein (LysE YggA)
C4J88_RS22205	COG3311	Transcriptional regulator
C4J88_RS22240	COG4251	negative regulation of phosphorylation
C4J88_RS22255	COG2853	Lipoprotein
C4J88_RS22270	COG3706	GGDEF domain
C4J88_RS22280	COG2161	toxin-antitoxin pair type II binding
C4J88_RS22295	COG1104	cysteine desulfurase activity
C4J88_RS22320	COG2197	response regulator
C4J88_RS22325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4J88_RS22330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4J88_RS22335	COG0109	protoheme IX farnesyltransferase activity
C4J88_RS22345	COG1845	cytochrome c oxidase, subunit III
C4J88_RS22350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4J88_RS22355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4J88_RS22365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J88_RS22370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J88_RS22370	COG1017	nitric oxide dioxygenase activity
C4J88_RS22375	COG3604	Transcriptional regulator
C4J88_RS22385	COG2207	Transcriptional regulator
C4J88_RS22385	COG3708	Transcriptional regulator
C4J88_RS22390	COG2197	response regulator
C4J88_RS22405	COG1028	Short-chain dehydrogenase reductase Sdr
C4J88_RS22425	COG1366	Belongs to the anti-sigma-factor antagonist family
C4J88_RS22450	COG0302	gtp cyclohydrolase
C4J88_RS22455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J88_RS22470	COG0492	ferredoxin-NADP+ reductase activity
C4J88_RS22480	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4J88_RS22495	COG0386	Belongs to the glutathione peroxidase family
C4J88_RS22500	COG3045	CreA protein
C4J88_RS22505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4J88_RS22510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4J88_RS22515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4J88_RS22520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4J88_RS22525	COG0142	geranyltranstransferase activity
C4J88_RS22530	COG2824	Alkylphosphonate utilization operon protein PhnA
C4J88_RS22535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J88_RS22540	COG0545	Peptidyl-prolyl cis-trans isomerase
C4J88_RS22555	COG1288	antiporter activity
C4J88_RS22565	COG0840	transmembrane signaling receptor activity
C4J88_RS22575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C4J88_RS22585	COG2610	gluconate transmembrane transporter activity
C4J88_RS22595	COG0659	secondary active sulfate transmembrane transporter activity
C4J88_RS22605	COG0583	DNA-binding transcription factor activity
C4J88_RS22615	COG0583	DNA-binding transcription factor activity
C4J88_RS22620	COG1113	amino acid transport
C4J88_RS22630	COG1522	sequence-specific DNA binding
C4J88_RS22635	COG3485	protocatechuate 3,4-dioxygenase
C4J88_RS22640	COG4829	muconolactone delta-isomerase
C4J88_RS22645	COG4948	Mandelate Racemase Muconate Lactonizing
C4J88_RS22660	COG4638	Rieske (2fe-2S)
C4J88_RS22665	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4J88_RS22670	COG0543	2 iron, 2 sulfur cluster binding
C4J88_RS22670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J88_RS22675	COG1113	amino acid transport
C4J88_RS22680	COG3483	tryptophan 2,3-dioxygenase activity
C4J88_RS22685	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4J88_RS22730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4J88_RS22735	COG1074	ATP-dependent DNA helicase activity
C4J88_RS22740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4J88_RS22775	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4J88_RS22780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4J88_RS22785	COG1183	phosphatidylcholine synthase activity
C4J88_RS22790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4J88_RS22800	COG0028	Belongs to the TPP enzyme family
C4J88_RS22805	COG3098	single-species biofilm formation
C4J88_RS22815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J88_RS22835	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4J88_RS22840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4J88_RS22845	COG4558	Periplasmic binding protein
C4J88_RS22855	COG1489	DNA binding
C4J88_RS22860	COG0436	Aminotransferase
C4J88_RS22870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4J88_RS22880	COG4191	Histidine kinase
C4J88_RS22900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4J88_RS22905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4J88_RS22910	COG0166	Belongs to the GPI family
C4J88_RS22915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4J88_RS22920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J88_RS22930	COG2823	Periplasmic or secreted lipoprotein
C4J88_RS22935	COG1185	polyribonucleotide nucleotidyltransferase activity
C4J88_RS22940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4J88_RS22945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4J88_RS22950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4J88_RS22955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4J88_RS22960	COG0195	Participates in both transcription termination and antitermination
C4J88_RS22965	COG0779	Required for maturation of 30S ribosomal subunits
C4J88_RS22980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4J88_RS22985	COG0149	triose-phosphate isomerase activity
C4J88_RS22990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J88_RS22995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4J88_RS23005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4J88_RS23020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J88_RS23025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4J88_RS23030	COG0505	Belongs to the CarA family
C4J88_RS23035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4J88_RS23040	COG0484	heat shock protein binding
C4J88_RS23045	COG0443	Heat shock 70 kDa protein
C4J88_RS23050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4J88_RS23055	COG0497	DNA recombination
C4J88_RS23060	COG0735	belongs to the Fur family
C4J88_RS23065	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4J88_RS23070	COG2914	Belongs to the UPF0125 (RnfH) family
C4J88_RS23080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4J88_RS23085	COG2186	Transcriptional regulator
C4J88_RS23090	COG1620	l-lactate permease
C4J88_RS23110	COG0582	viral genome integration into host DNA
C4J88_RS23125	COG4983	Phage plasmid primase, P4 family domain protein
C4J88_RS23200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4J88_RS23205	COG3781	membrane
C4J88_RS23220	COG2862	Uncharacterized protein family, UPF0114
C4J88_RS23235	COG1067	ATP-dependent peptidase activity
C4J88_RS23255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J88_RS23265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4J88_RS23290	COG2814	Major facilitator Superfamily
C4J88_RS23295	COG0583	DNA-binding transcription factor activity
C4J88_RS23300	COG0488	(ABC) transporter
C4J88_RS23315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J88_RS23320	COG0523	cobalamin synthesis protein
C4J88_RS23325	COG2879	small protein
C4J88_RS23330	COG1966	Carbon starvation protein
C4J88_RS23350	COG1970	mechanosensitive ion channel activity
C4J88_RS23365	COG2813	Specifically methylates the guanine in position
C4J88_RS23375	COG1294	oxidase, subunit
C4J88_RS23380	COG1271	oxidase subunit
C4J88_RS23390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4J88_RS23395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4J88_RS23400	COG2080	2 iron, 2 sulfur cluster binding
C4J88_RS23410	COG2252	PERMEase
C4J88_RS23415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4J88_RS23430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4J88_RS23435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4J88_RS23440	COG1309	transcriptional regulator
C4J88_RS23445	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4J88_RS23445	COG1082	Xylose isomerase domain protein TIM barrel
C4J88_RS23450	COG0477	Major facilitator Superfamily
C4J88_RS23465	COG2321	neutral zinc metallopeptidase
C4J88_RS23480	COG1946	Acyl-CoA thioesterase
C4J88_RS23490	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4J88_RS23495	COG0493	'glutamate synthase
C4J88_RS23495	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J88_RS23500	COG0513	Belongs to the DEAD box helicase family
C4J88_RS23505	COG0697	spore germination
C4J88_RS23520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J88_RS23520	COG1199	ATP-dependent helicase activity
C4J88_RS23530	COG3416	Protein conserved in bacteria
C4J88_RS23550	COG1643	Atp-dependent helicase
C4J88_RS23565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C4J88_RS23575	COG1522	sequence-specific DNA binding
C4J88_RS23590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4J88_RS23595	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS23605	COG0351	phosphomethylpyrimidine kinase
C4J88_RS23610	COG0352	thiamine-phosphate diphosphorylase activity
C4J88_RS23615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4J88_RS23630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4J88_RS23635	COG1702	phosphate starvation-inducible protein PhoH
C4J88_RS23640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4J88_RS23645	COG4535	Mg2 and Co2 transporter CorC
C4J88_RS23650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4J88_RS23665	COG0495	leucyl-tRNA aminoacylation
C4J88_RS23675	COG1466	dna polymerase III delta subunit
C4J88_RS23685	COG2951	lytic endotransglycosylase activity
C4J88_RS23690	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4J88_RS23695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4J88_RS23700	COG0321	lipoyl(octanoyl) transferase activity
C4J88_RS23705	COG2921	Belongs to the UPF0250 family
C4J88_RS23710	COG1686	Belongs to the peptidase S11 family
C4J88_RS23720	COG2951	lytic endotransglycosylase activity
C4J88_RS23725	COG0772	Belongs to the SEDS family
C4J88_RS23730	COG0768	penicillin binding
C4J88_RS23735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4J88_RS23745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4J88_RS23750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4J88_RS23755	COG2094	Belongs to the DNA glycosylase MPG family
C4J88_RS23760	COG0586	Pfam SNARE associated Golgi protein
C4J88_RS23775	COG1346	cytolysis
C4J88_RS23795	COG0702	epimerase
C4J88_RS23810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4J88_RS23815	COG3284	Transcriptional regulator
C4J88_RS23825	COG0531	amino acid
C4J88_RS23830	COG4303	Ethanolamine ammonia lyase large subunit
C4J88_RS23835	COG4302	ethanolamine ammonia-lyase activity
C4J88_RS23840	COG0456	acetyltransferase
C4J88_RS23845	COG0586	Pfam SNARE associated Golgi protein
C4J88_RS23850	COG3228	Belongs to the MtfA family
C4J88_RS23855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4J88_RS23875	COG1335	isochorismatase
C4J88_RS23880	COG4804	nuclease activity
C4J88_RS23890	COG3209	COG3209 Rhs family protein
C4J88_RS23905	COG1722	exodeoxyribonuclease VII activity
C4J88_RS23910	COG0142	geranyltranstransferase activity
C4J88_RS23915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4J88_RS23920	COG4206	TonB-dependent receptor
C4J88_RS23935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4J88_RS23945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4J88_RS23950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4J88_RS23955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4J88_RS23970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J88_RS23970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4J88_RS23975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4J88_RS23985	COG2264	protein methyltransferase activity
C4J88_RS23995	COG3118	belongs to the thioredoxin family
C4J88_RS24035	COG1201	RNA secondary structure unwinding
C4J88_RS24040	COG0668	transmembrane transport
C4J88_RS24050	COG3568	Endonuclease Exonuclease Phosphatase
C4J88_RS24060	COG0392	lysyltransferase activity
C4J88_RS24075	COG1335	isochorismatase
C4J88_RS24080	COG4106	trans-aconitate 2-methyltransferase activity
C4J88_RS24085	COG0629	single-stranded DNA binding
C4J88_RS24090	COG2814	Major facilitator Superfamily
C4J88_RS24095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4J88_RS24100	COG2193	ferroxidase activity
C4J88_RS24110	COG0203	ribosomal protein L17
C4J88_RS24115	COG0202	RNA polymerase activity
C4J88_RS24120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4J88_RS24125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4J88_RS24130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4J88_RS24135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4J88_RS24145	COG0200	Binds to the 23S rRNA
C4J88_RS24150	COG1841	ribosomal large subunit assembly
C4J88_RS24155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4J88_RS24160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4J88_RS24165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4J88_RS24170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4J88_RS24175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4J88_RS24180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4J88_RS24185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4J88_RS24190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4J88_RS24195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4J88_RS24200	COG0255	Belongs to the universal ribosomal protein uL29 family
C4J88_RS24205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4J88_RS24210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4J88_RS24215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4J88_RS24220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4J88_RS24225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4J88_RS24230	COG0089	rRNA binding
C4J88_RS24235	COG0088	Forms part of the polypeptide exit tunnel
C4J88_RS24240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4J88_RS24245	COG0051	transcription antitermination factor activity, RNA binding
C4J88_RS24250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4J88_RS24255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4J88_RS24260	COG0049	tRNA binding
C4J88_RS24265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4J88_RS24270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4J88_RS24275	COG0085	RNA polymerase activity
C4J88_RS24280	COG0222	ribosome binding
C4J88_RS24285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4J88_RS24290	COG0081	regulation of translation
C4J88_RS24295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4J88_RS24335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4J88_RS24375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4J88_RS24385	COG0739	heme binding
C4J88_RS24390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4J88_RS24395	COG0316	Belongs to the HesB IscA family
C4J88_RS24400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4J88_RS24405	COG1981	membrane
C4J88_RS24420	COG4221	oxidoreductase activity
C4J88_RS24425	COG0537	adenosine 5'-monophosphoramidase activity
C4J88_RS24430	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4J88_RS24435	COG1765	OsmC-like protein
C4J88_RS24450	COG0134	indole-3-glycerol-phosphate synthase activity
C4J88_RS24455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4J88_RS24460	COG0512	Glutamine amidotransferase of anthranilate synthase
C4J88_RS24465	COG3240	lipase activity
C4J88_RS24465	COG4625	pathogenesis
C4J88_RS24470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4J88_RS24475	COG0546	phosphoglycolate phosphatase activity
C4J88_RS24480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4J88_RS24485	COG1454	alcohol dehydrogenase
C4J88_RS24495	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J88_RS24505	COG3842	ATPase activity
C4J88_RS24510	COG2197	response regulator
C4J88_RS24525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4J88_RS24530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4J88_RS24535	COG3178	'Phosphotransferase
C4J88_RS24540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4J88_RS24545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4J88_RS24550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4J88_RS24555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4J88_RS24560	COG2967	ApaG domain
C4J88_RS24565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4J88_RS24570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4J88_RS24575	COG2766	serine protein kinase
C4J88_RS24580	COG2718	Belongs to the UPF0229 family
C4J88_RS24585	COG2719	SpoVR family
C4J88_RS24590	COG0617	tRNA 3'-terminal CCA addition
C4J88_RS24600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4J88_RS24605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4J88_RS24610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4J88_RS24615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4J88_RS24620	COG0358	DNA primase activity
C4J88_RS24625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4J88_RS24660	COG4695	Portal protein
C4J88_RS24700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4J88_RS24705	COG1025	Belongs to the peptidase M16 family
C4J88_RS24715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4J88_RS24720	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4J88_RS24730	COG0535	radical SAM domain protein
C4J88_RS24740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4J88_RS24745	COG0583	DNA-binding transcription factor activity
C4J88_RS24750	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS24755	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS24765	COG1960	acyl-CoA dehydrogenase activity
C4J88_RS24785	COG1073	alpha beta
C4J88_RS24785	COG2226	methyltransferase
C4J88_RS24790	COG0156	8-amino-7-oxononanoate synthase activity
C4J88_RS24795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4J88_RS24805	COG3585	molybdate ion transport
C4J88_RS24805	COG2005	Transcriptional regulator
C4J88_RS24815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4J88_RS24830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4J88_RS24835	COG4566	intracellular signal transduction
C4J88_RS24835	COG0745	RESPONSE REGULATOR receiver
C4J88_RS24845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4J88_RS24850	COG1595	DNA-templated transcription, initiation
C4J88_RS24860	COG4774	siderophore transport
C4J88_RS24885	COG4452	Inner membrane protein CreD
C4J88_RS24890	COG2205	protein histidine kinase activity
C4J88_RS24895	COG0745	RESPONSE REGULATOR receiver
C4J88_RS24900	COG4067	protein conserved in archaea
C4J88_RS24900	COG0189	ligase activity
C4J88_RS24905	COG0204	Acyl-transferase
C4J88_RS24920	COG1063	alcohol dehydrogenase
C4J88_RS24950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4J88_RS24975	COG1017	nitric oxide dioxygenase activity
C4J88_RS24975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4J88_RS24980	COG4638	Rieske (2fe-2S)
C4J88_RS24990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4J88_RS24995	COG0247	lactate metabolic process
C4J88_RS24995	COG2181	nitrate reductase activity
C4J88_RS25000	COG1902	pentaerythritol trinitrate reductase activity
C4J88_RS25000	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4J88_RS25035	COG3246	L-lysine catabolic process to acetate
C4J88_RS25040	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4J88_RS25065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4J88_RS25070	COG0493	'glutamate synthase
C4J88_RS25075	COG0067	glutamate synthase
C4J88_RS25075	COG0069	glutamate synthase activity
C4J88_RS25075	COG0070	glutamate synthase
C4J88_RS25090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4J88_RS25095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4J88_RS25125	COG0281	malic enzyme
C4J88_RS25135	COG0254	rRNA binding
C4J88_RS25140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4J88_RS25145	COG0018	arginyl-trna synthetase
C4J88_RS25155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4J88_RS25160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4J88_RS25205	COG2226	methyltransferase
C4J88_RS25215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4J88_RS25220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4J88_RS25225	COG0140	phosphoribosyl-ATP diphosphatase activity
C4J88_RS25230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J88_RS25235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4J88_RS25275	COG2116	formate transmembrane transporter activity
C4J88_RS25285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4J88_RS25290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4J88_RS25305	COG0513	Belongs to the DEAD box helicase family
C4J88_RS25310	COG2353	YceI-like domain
C4J88_RS25315	COG3038	cytochrome b561
C4J88_RS25325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4J88_RS25330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS25350	COG1272	protein, Hemolysin III
C4J88_RS25375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4J88_RS25395	COG3052	prosthetic group binding
C4J88_RS25400	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4J88_RS25430	COG0643	Histidine kinase
C4J88_RS25430	COG0784	Response regulator, receiver
C4J88_RS25430	COG2198	Histidine kinase
C4J88_RS25455	COG0189	ligase activity
C4J88_RS25470	COG1678	Uncharacterized ACR, COG1678
C4J88_RS25475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4J88_RS25480	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4J88_RS25485	COG0540	Belongs to the ATCase OTCase family
C4J88_RS25490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J88_RS25500	COG0791	NLP P60 protein
C4J88_RS25525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J88_RS25530	COG2813	Specifically methylates the guanine in position
C4J88_RS25530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4J88_RS25540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4J88_RS25545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4J88_RS25555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4J88_RS25560	COG2022	thiamine diphosphate biosynthetic process
C4J88_RS25570	COG2363	Small membrane protein
C4J88_RS25575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4J88_RS25585	COG2177	Part of the ABC transporter FtsEX involved in
C4J88_RS25590	COG2884	Cell division ATP-binding protein ftsE
C4J88_RS25595	COG0552	protein localization to endoplasmic reticulum
C4J88_RS25600	COG0612	Peptidase, M16
C4J88_RS25605	COG0612	Peptidase, M16
C4J88_RS25610	COG0742	ribosomal rna small subunit methyltransferase
C4J88_RS25615	COG0429	hydrolase of the alpha beta-hydrolase fold
C4J88_RS25630	COG1309	transcriptional regulator
C4J88_RS25645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4J88_RS25650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4J88_RS25655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4J88_RS25660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4J88_RS25670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4J88_RS25675	COG2814	Major facilitator Superfamily
C4J88_RS25685	COG0129	dihydroxy-acid dehydratase activity
C4J88_RS25695	COG1823	symporter activity
C4J88_RS25710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4J88_RS25720	COG1840	ABC-type Fe3 transport system, periplasmic component
C4J88_RS25725	COG1178	ABC-type Fe3 transport system permease component
C4J88_RS25730	COG3842	ATPase activity
C4J88_RS25740	COG0583	DNA-binding transcription factor activity
C4J88_RS25750	COG0789	Transcriptional regulator
C4J88_RS25755	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4J88_RS25760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4J88_RS25775	COG0494	nUDIX hydrolase
C4J88_RS25790	COG0702	epimerase
C4J88_RS25800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4J88_RS25805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4J88_RS25810	COG2234	aminopeptidase activity
C4J88_RS25815	COG3204	pilus organization
C4J88_RS25820	COG3204	pilus organization
C4J88_RS25825	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4J88_RS25830	COG0277	FAD linked oxidase domain protein
C4J88_RS25840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4J88_RS25850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS25895	COG1177	transmembrane transport
C4J88_RS25900	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4J88_RS25905	COG3842	ATPase activity
C4J88_RS25930	COG0174	glutamine synthetase
C4J88_RS25935	COG0174	glutamine synthetase
C4J88_RS25950	COG1116	anion transmembrane transporter activity
C4J88_RS25955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4J88_RS25965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4J88_RS25970	COG0431	NADPH-dependent FMN reductase
C4J88_RS25975	COG0450	alkyl hydroperoxide reductase
C4J88_RS25985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4J88_RS25985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J88_RS26000	COG1522	sequence-specific DNA binding
C4J88_RS26010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4J88_RS26015	COG0330	HflC and HflK could
C4J88_RS26030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4J88_RS26035	COG0509	glycine decarboxylation via glycine cleavage system
C4J88_RS26040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4J88_RS26045	COG1178	ABC-type Fe3 transport system permease component
C4J88_RS26055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J88_RS26060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4J88_RS26065	COG0006	proline dipeptidase activity
C4J88_RS26070	COG3079	Belongs to the UPF0149 family
C4J88_RS26090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4J88_RS26115	COG2271	Major facilitator Superfamily
C4J88_RS26130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4J88_RS26150	COG2186	Transcriptional regulator
C4J88_RS26155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS26160	COG0765	amino acid transport
C4J88_RS26165	COG0765	amino acid transport
C4J88_RS26170	COG1126	abc transporter atp-binding protein
C4J88_RS26180	COG3188	usher protein
C4J88_RS26185	COG3121	Chaperone
C4J88_RS26200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4J88_RS26210	COG0586	Pfam SNARE associated Golgi protein
C4J88_RS26220	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4J88_RS26225	COG1671	Belongs to the UPF0178 family
C4J88_RS26230	COG0672	)-iron permease
C4J88_RS26235	COG1280	lysine exporter protein (LysE YggA)
C4J88_RS26245	COG0488	(ABC) transporter
C4J88_RS26270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4J88_RS26285	COG0181	hydroxymethylbilane synthase activity
C4J88_RS26295	COG0165	Argininosuccinate lyase
C4J88_RS26300	COG0625	glutathione transferase activity
C4J88_RS26320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4J88_RS26330	COG1965	Belongs to the frataxin family
C4J88_RS26340	COG0019	diaminopimelate decarboxylase activity
C4J88_RS26345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4J88_RS26355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4J88_RS26360	COG1011	Hydrolase
C4J88_RS26370	COG0432	Pfam Uncharacterised protein family UPF0047
C4J88_RS26375	COG0004	ammonium transporteR
C4J88_RS26380	COG0347	Belongs to the P(II) protein family
C4J88_RS26390	COG0606	chelatase, subunit chli
C4J88_RS26395	COG0840	transmembrane signaling receptor activity
C4J88_RS26400	COG0583	DNA-binding transcription factor activity
C4J88_RS26405	COG0534	Mate efflux family protein
C4J88_RS26420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4J88_RS26425	COG0427	acetyl-CoA hydrolase
C4J88_RS26440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4J88_RS26445	COG0251	oxidation-reduction process
C4J88_RS26450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS26465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4J88_RS26475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4J88_RS26480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J88_RS26490	COG1012	belongs to the aldehyde dehydrogenase family
C4J88_RS26500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4J88_RS26505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4J88_RS26510	COG0747	negative chemotaxis
C4J88_RS26515	COG2003	Belongs to the UPF0758 family
C4J88_RS26520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4J88_RS26525	COG0756	dUTP diphosphatase activity
C4J88_RS26535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4J88_RS26540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4J88_RS26545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4J88_RS26550	COG0708	Exodeoxyribonuclease III
C4J88_RS26560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4J88_RS26565	COG1561	YicC-like family, N-terminal region
C4J88_RS26570	COG0194	GDP metabolic process
C4J88_RS26575	COG1758	RNA polymerase activity
C4J88_RS26580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4J88_RS26605	COG0848	biopolymer transport protein
C4J88_RS26615	COG0583	DNA-binding transcription factor activity
C4J88_RS26620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4J88_RS26660	COG1136	(ABC) transporter
C4J88_RS26665	COG2815	serine threonine protein kinase
C4J88_RS26665	COG0515	serine threonine protein kinase
C4J88_RS26670	COG0631	protein serine/threonine phosphatase activity
C4J88_RS26790	COG3161	chorismate lyase activity
C4J88_RS26795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4J88_RS26815	COG1253	flavin adenine dinucleotide binding
C4J88_RS26825	COG0704	Plays a role in the regulation of phosphate uptake
C4J88_RS26830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4J88_RS26835	COG0573	inorganic phosphate transmembrane transporter activity
C4J88_RS26860	COG0477	Major facilitator Superfamily
C4J88_RS26865	COG1607	acyl-coa hydrolase
C4J88_RS26895	COG0583	DNA-binding transcription factor activity
C4J88_RS26900	COG1027	Aspartate ammonia-lyase
C4J88_RS26905	COG1115	amino acid carrier protein
C4J88_RS26910	COG0252	asparaginase activity
C4J88_RS26950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4J88_RS26955	COG0765	amino acid transport
C4J88_RS26970	COG5016	pyruvate
C4J88_RS26970	COG0511	ligase activity, forming carbon-carbon bonds
C4J88_RS26975	COG0439	Biotin carboxylase
C4J88_RS26980	COG0583	DNA-binding transcription factor activity
C4J88_RS27000	COG3300	MHYT domain
C4J88_RS27000	COG5001	Diguanylate cyclase
C4J88_RS27005	COG0210	DNA helicase
C4J88_RS27025	COG4651	solute:proton antiporter activity
C4J88_RS27025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4J88_RS27030	COG1607	acyl-coa hydrolase
C4J88_RS27035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4J88_RS27045	COG0523	cobalamin synthesis protein
C4J88_RS27065	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4J88_RS27070	COG1469	GTP cyclohydrolase I activity
C4J88_RS27075	COG1121	(ABC) transporter
C4J88_RS27095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4J88_RS27105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4J88_RS27110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4J88_RS27150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4J88_RS27155	COG2267	carboxylic ester hydrolase activity
C4J88_RS27160	COG0671	phosphoesterase, PA-phosphatase related
C4J88_RS27160	COG2453	phosphatase
C4J88_RS27175	COG4589	Belongs to the CDS family
C4J88_RS27180	COG0596	Alpha beta hydrolase
C4J88_RS27185	COG0583	DNA-binding transcription factor activity
C4J88_RS27190	COG0066	3-isopropylmalate dehydratase activity
C4J88_RS27195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4J88_RS27205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4J88_RS27210	COG1349	DNA-binding transcription factor activity
C4J88_RS27215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4J88_RS27225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4J88_RS27230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4J88_RS27235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4J88_RS27240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4J88_RS27245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4J88_RS27250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4J88_RS27260	COG0356	it plays a direct role in the translocation of protons across the membrane
C4J88_RS27265	COG3312	ion transport
C4J88_RS27270	COG1475	DNA binding
C4J88_RS27275	COG1192	Involved in chromosome partitioning
C4J88_RS27280	COG0357	Ribosomal RNA small subunit methyltransferase G
C4J88_RS27285	COG0445	tRNA wobble uridine modification
C4J88_RS27290	COG1595	DNA-templated transcription, initiation
C4J88_RS27305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4J88_RS27310	COG0706	membrane insertase activity
C4J88_RS27315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4J88_RS27320	COG0594	ribonuclease P activity
C4J88_RS27325	COG0230	Belongs to the bacterial ribosomal protein bL34 family