locus-tag	class	description
PRtIB026_RS00030	COG0494	nUDIX hydrolase
PRtIB026_RS00035	COG1011	Hydrolase
PRtIB026_RS00040	COG1652	LysM domain
PRtIB026_RS00045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PRtIB026_RS00050	COG0243	molybdopterin cofactor binding
PRtIB026_RS00065	COG2197	response regulator
PRtIB026_RS00075	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PRtIB026_RS00080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PRtIB026_RS00090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PRtIB026_RS00100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PRtIB026_RS00105	COG0006	proline dipeptidase activity
PRtIB026_RS00145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS00185	COG1464	Belongs to the NlpA lipoprotein family
PRtIB026_RS00190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PRtIB026_RS00195	COG2011	ABC-type metal ion transport system permease component
PRtIB026_RS00210	COG2199	diguanylate cyclase activity
PRtIB026_RS00215	COG3692	DNA binding
PRtIB026_RS00225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PRtIB026_RS00230	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS00240	COG4771	TonB-dependent receptor
PRtIB026_RS00255	COG1663	tetraacyldisaccharide 4'-kinase activity
PRtIB026_RS00260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS00280	COG0517	IMP dehydrogenase activity
PRtIB026_RS00310	COG1280	lysine exporter protein (LysE YggA)
PRtIB026_RS00320	COG0488	(ABC) transporter
PRtIB026_RS00345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PRtIB026_RS00365	COG0181	hydroxymethylbilane synthase activity
PRtIB026_RS00375	COG0165	Argininosuccinate lyase
PRtIB026_RS00380	COG0625	glutathione transferase activity
PRtIB026_RS00395	COG3072	Adenylate cyclase
PRtIB026_RS00400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PRtIB026_RS00410	COG1965	Belongs to the frataxin family
PRtIB026_RS00420	COG0019	diaminopimelate decarboxylase activity
PRtIB026_RS00425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PRtIB026_RS00435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PRtIB026_RS00440	COG0546	phosphoglycolate phosphatase activity
PRtIB026_RS00450	COG0004	ammonium transporteR
PRtIB026_RS00455	COG0347	Belongs to the P(II) protein family
PRtIB026_RS00485	COG0606	chelatase, subunit chli
PRtIB026_RS00520	COG0210	DNA helicase
PRtIB026_RS00610	COG3093	addiction module antidote protein HigA
PRtIB026_RS00620	COG0583	DNA-binding transcription factor activity
PRtIB026_RS00635	COG1335	isochorismatase
PRtIB026_RS00645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS00650	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS00655	COG0583	DNA-binding transcription factor activity
PRtIB026_RS00665	COG0840	transmembrane signaling receptor activity
PRtIB026_RS00675	COG0534	Mate efflux family protein
PRtIB026_RS00705	COG3791	Glutathione-dependent formaldehyde-activating
PRtIB026_RS00710	COG2851	Citrate transporter
PRtIB026_RS00715	COG0861	Integral membrane protein TerC family
PRtIB026_RS00720	COG1283	sodium-dependent phosphate transmembrane transporter activity
PRtIB026_RS00740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PRtIB026_RS00745	COG1127	ABC transporter
PRtIB026_RS00760	COG0700	Nucleoside recognition
PRtIB026_RS00765	COG1301	dicarboxylic acid transport
PRtIB026_RS00785	COG2204	response regulator
PRtIB026_RS00790	COG5002	protein histidine kinase activity
PRtIB026_RS00800	COG3023	N-Acetylmuramoyl-L-alanine amidase
PRtIB026_RS00815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PRtIB026_RS00825	COG3245	cytochrome
PRtIB026_RS00830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PRtIB026_RS00850	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PRtIB026_RS00855	COG0735	belongs to the Fur family
PRtIB026_RS00860	COG1121	(ABC) transporter
PRtIB026_RS00865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PRtIB026_RS00880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PRtIB026_RS00885	COG2011	ABC-type metal ion transport system permease component
PRtIB026_RS00900	COG0109	protoheme IX farnesyltransferase activity
PRtIB026_RS00930	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PRtIB026_RS00935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PRtIB026_RS00940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PRtIB026_RS00950	COG0659	secondary active sulfate transmembrane transporter activity
PRtIB026_RS00965	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PRtIB026_RS00970	COG0339	signal peptide processing
PRtIB026_RS00975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PRtIB026_RS01005	COG1764	response to oxidative stress
PRtIB026_RS01010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PRtIB026_RS01020	COG3360	Dodecin
PRtIB026_RS01035	COG0133	tryptophan synthase activity
PRtIB026_RS01040	COG0159	tryptophan synthase activity
PRtIB026_RS01055	COG3119	arylsulfatase activity
PRtIB026_RS01065	COG0659	secondary active sulfate transmembrane transporter activity
PRtIB026_RS01070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PRtIB026_RS01075	COG0408	coproporphyrinogen oxidase activity
PRtIB026_RS01085	COG4115	mRNA cleavage
PRtIB026_RS01090	COG2161	toxin-antitoxin pair type II binding
PRtIB026_RS01100	COG0009	L-threonylcarbamoyladenylate synthase
PRtIB026_RS01105	COG0758	DNA mediated transformation
PRtIB026_RS01110	COG0242	peptide deformylase activity
PRtIB026_RS01115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PRtIB026_RS01120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PRtIB026_RS01125	COG0569	domain protein
PRtIB026_RS01140	COG2818	Glycosylase
PRtIB026_RS01145	COG0752	glycyl-tRNA synthetase alpha subunit
PRtIB026_RS01150	COG0751	glycine-tRNA ligase activity
PRtIB026_RS01155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PRtIB026_RS01165	COG0477	Major facilitator Superfamily
PRtIB026_RS01215	COG0187	DNA topoisomerase II activity
PRtIB026_RS01220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PRtIB026_RS01225	COG0592	DNA-directed DNA polymerase activity
PRtIB026_RS01230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PRtIB026_RS01235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PRtIB026_RS01240	COG0594	ribonuclease P activity
PRtIB026_RS01245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PRtIB026_RS01260	COG0445	tRNA wobble uridine modification
PRtIB026_RS01265	COG0357	Ribosomal RNA small subunit methyltransferase G
PRtIB026_RS01270	COG1192	Involved in chromosome partitioning
PRtIB026_RS01275	COG1475	DNA binding
PRtIB026_RS01280	COG3312	ion transport
PRtIB026_RS01285	COG0356	it plays a direct role in the translocation of protons across the membrane
PRtIB026_RS01295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PRtIB026_RS01300	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PRtIB026_RS01305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PRtIB026_RS01310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PRtIB026_RS01315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PRtIB026_RS01320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PRtIB026_RS01325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PRtIB026_RS01330	COG1349	DNA-binding transcription factor activity
PRtIB026_RS01335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PRtIB026_RS01345	COG3422	double-strand break repair
PRtIB026_RS01380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PRtIB026_RS01385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PRtIB026_RS01390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PRtIB026_RS01400	COG1469	GTP cyclohydrolase I activity
PRtIB026_RS01420	COG0523	cobalamin synthesis protein
PRtIB026_RS01430	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PRtIB026_RS01435	COG1607	acyl-coa hydrolase
PRtIB026_RS01440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PRtIB026_RS01440	COG4651	solute:proton antiporter activity
PRtIB026_RS01455	COG0210	DNA helicase
PRtIB026_RS01460	COG3300	MHYT domain
PRtIB026_RS01460	COG5001	Diguanylate cyclase
PRtIB026_RS01465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PRtIB026_RS01480	COG0583	DNA-binding transcription factor activity
PRtIB026_RS01485	COG0439	Biotin carboxylase
PRtIB026_RS01490	COG0511	ligase activity, forming carbon-carbon bonds
PRtIB026_RS01490	COG5016	pyruvate
PRtIB026_RS01530	COG1027	Aspartate ammonia-lyase
PRtIB026_RS01535	COG0583	DNA-binding transcription factor activity
PRtIB026_RS01560	COG0676	glucose-6-phosphate 1-epimerase activity
PRtIB026_RS01565	COG1607	acyl-coa hydrolase
PRtIB026_RS01585	COG0581	inorganic phosphate transmembrane transporter activity
PRtIB026_RS01590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PRtIB026_RS01595	COG0704	Plays a role in the regulation of phosphate uptake
PRtIB026_RS01605	COG0739	heme binding
PRtIB026_RS01610	COG1253	flavin adenine dinucleotide binding
PRtIB026_RS01630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PRtIB026_RS01635	COG3161	chorismate lyase activity
PRtIB026_RS01665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PRtIB026_RS01670	COG0583	DNA-binding transcription factor activity
PRtIB026_RS01680	COG0848	biopolymer transport protein
PRtIB026_RS01705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PRtIB026_RS01710	COG1758	RNA polymerase activity
PRtIB026_RS01720	COG0174	glutamine synthetase
PRtIB026_RS01725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PRtIB026_RS01735	COG0194	GDP metabolic process
PRtIB026_RS01740	COG1561	YicC-like family, N-terminal region
PRtIB026_RS01745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PRtIB026_RS01750	COG0708	Exodeoxyribonuclease III
PRtIB026_RS01755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PRtIB026_RS01760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PRtIB026_RS01770	COG0756	dUTP diphosphatase activity
PRtIB026_RS01775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PRtIB026_RS01780	COG2003	Belongs to the UPF0758 family
PRtIB026_RS01800	COG0747	negative chemotaxis
PRtIB026_RS01805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PRtIB026_RS01810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PRtIB026_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS01830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PRtIB026_RS01835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PRtIB026_RS01845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS01860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS01865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PRtIB026_RS01885	COG0427	acetyl-CoA hydrolase
PRtIB026_RS01890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PRtIB026_RS01905	COG0427	acetyl-CoA hydrolase
PRtIB026_RS01925	COG0583	DNA-binding transcription factor activity
PRtIB026_RS01930	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS02000	COG1802	Transcriptional regulator
PRtIB026_RS02040	COG2274	protein secretion by the type I secretion system
PRtIB026_RS02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS02050	COG2175	clavaminate synthase activity
PRtIB026_RS02065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS02095	COG1566	PFAM secretion protein HlyD family protein
PRtIB026_RS02125	COG0672	)-iron permease
PRtIB026_RS02130	COG1671	Belongs to the UPF0178 family
PRtIB026_RS02135	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PRtIB026_RS02145	COG0586	Pfam SNARE associated Golgi protein
PRtIB026_RS02155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PRtIB026_RS02175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PRtIB026_RS02190	COG1126	abc transporter atp-binding protein
PRtIB026_RS02195	COG0765	amino acid transport
PRtIB026_RS02200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS02205	COG1045	serine acetyltransferase
PRtIB026_RS02210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PRtIB026_RS02215	COG2175	clavaminate synthase activity
PRtIB026_RS02220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS02225	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PRtIB026_RS02230	COG4521	taurine ABC transporter
PRtIB026_RS02240	COG0450	alkyl hydroperoxide reductase
PRtIB026_RS02245	COG0431	NADPH-dependent FMN reductase
PRtIB026_RS02250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PRtIB026_RS02255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PRtIB026_RS02260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS02265	COG1116	anion transmembrane transporter activity
PRtIB026_RS02280	COG2918	glutathione biosynthetic process
PRtIB026_RS02290	COG2183	response to ionizing radiation
PRtIB026_RS02305	COG0189	ligase activity
PRtIB026_RS02310	COG0189	ligase activity
PRtIB026_RS02310	COG4067	protein conserved in archaea
PRtIB026_RS02315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PRtIB026_RS02325	COG1178	ABC-type Fe3 transport system permease component
PRtIB026_RS02330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PRtIB026_RS02335	COG0509	glycine decarboxylation via glycine cleavage system
PRtIB026_RS02340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PRtIB026_RS02340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PRtIB026_RS02350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PRtIB026_RS02360	COG1522	sequence-specific DNA binding
PRtIB026_RS02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PRtIB026_RS02375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PRtIB026_RS02380	COG0174	glutamine synthetase
PRtIB026_RS02385	COG0174	glutamine synthetase
PRtIB026_RS02405	COG3842	ATPase activity
PRtIB026_RS02410	COG1176	ABC-type spermidine putrescine transport system, permease component I
PRtIB026_RS02415	COG1177	transmembrane transport
PRtIB026_RS02435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PRtIB026_RS02445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PRtIB026_RS02455	COG4208	sulfate ABC transporter
PRtIB026_RS02460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PRtIB026_RS02485	COG3829	transcription factor binding
PRtIB026_RS02495	COG0765	amino acid transport
PRtIB026_RS02500	COG0765	amino acid transport
PRtIB026_RS02505	COG1126	abc transporter atp-binding protein
PRtIB026_RS02510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS02545	COG1683	Conserved Protein
PRtIB026_RS02550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS02560	COG0583	DNA-binding transcription factor activity
PRtIB026_RS02570	COG0789	Transcriptional regulator
PRtIB026_RS02575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PRtIB026_RS02580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PRtIB026_RS02585	COG0730	response to heat
PRtIB026_RS02605	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PRtIB026_RS02620	COG2223	nitrite transmembrane transporter activity
PRtIB026_RS02625	COG0131	Imidazoleglycerol-phosphate dehydratase
PRtIB026_RS02630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PRtIB026_RS02640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PRtIB026_RS02645	COG0107	imidazoleglycerol-phosphate synthase activity
PRtIB026_RS02650	COG3291	Pkd domain containing protein
PRtIB026_RS02655	COG4175	Glycine betaine
PRtIB026_RS02660	COG4176	ABC-type proline glycine betaine transport system permease component
PRtIB026_RS02670	COG1760	l-serine dehydratase
PRtIB026_RS02690	COG1250	3-hydroxyacyl-CoA dehydrogenase
PRtIB026_RS02695	COG3246	L-lysine catabolic process to acetate
PRtIB026_RS02725	COG0446	pyridine nucleotide-disulphide oxidoreductase
PRtIB026_RS02725	COG1902	pentaerythritol trinitrate reductase activity
PRtIB026_RS02730	COG0247	lactate metabolic process
PRtIB026_RS02730	COG2181	nitrate reductase activity
PRtIB026_RS02735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PRtIB026_RS02760	COG4638	Rieske (2fe-2S)
PRtIB026_RS02765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PRtIB026_RS02765	COG1017	nitric oxide dioxygenase activity
PRtIB026_RS02785	COG0840	transmembrane signaling receptor activity
PRtIB026_RS02795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PRtIB026_RS02825	COG1063	alcohol dehydrogenase
PRtIB026_RS02845	COG0204	Acyl-transferase
PRtIB026_RS02860	COG2205	protein histidine kinase activity
PRtIB026_RS02865	COG4452	Inner membrane protein CreD
PRtIB026_RS02875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PRtIB026_RS02895	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PRtIB026_RS02910	COG0438	transferase activity, transferring glycosyl groups
PRtIB026_RS02945	COG4774	siderophore transport
PRtIB026_RS02950	COG3712	iron ion homeostasis
PRtIB026_RS02955	COG1595	DNA-templated transcription, initiation
PRtIB026_RS02960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PRtIB026_RS02975	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PRtIB026_RS03000	COG1040	competence protein
PRtIB026_RS03005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PRtIB026_RS03010	COG0156	8-amino-7-oxononanoate synthase activity
PRtIB026_RS03035	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS03040	COG3706	GGDEF domain
PRtIB026_RS03045	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS03050	COG0583	DNA-binding transcription factor activity
PRtIB026_RS03055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PRtIB026_RS03070	COG0535	radical SAM domain protein
PRtIB026_RS03080	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PRtIB026_RS03085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PRtIB026_RS03095	COG1025	Belongs to the peptidase M16 family
PRtIB026_RS03100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PRtIB026_RS03110	COG2944	sequence-specific DNA binding
PRtIB026_RS03125	COG0110	maltose O-acetyltransferase activity
PRtIB026_RS03135	COG1690	Belongs to the RtcB family
PRtIB026_RS03140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PRtIB026_RS03165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PRtIB026_RS03170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PRtIB026_RS03175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PRtIB026_RS03180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PRtIB026_RS03190	COG0617	tRNA 3'-terminal CCA addition
PRtIB026_RS03195	COG2719	SpoVR family
PRtIB026_RS03200	COG2718	Belongs to the UPF0229 family
PRtIB026_RS03205	COG2766	serine protein kinase
PRtIB026_RS03210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PRtIB026_RS03215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PRtIB026_RS03220	COG2967	ApaG domain
PRtIB026_RS03225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PRtIB026_RS03230	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PRtIB026_RS03235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PRtIB026_RS03240	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PRtIB026_RS03250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PRtIB026_RS03255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PRtIB026_RS03270	COG2197	response regulator
PRtIB026_RS03275	COG3842	ATPase activity
PRtIB026_RS03285	COG1176	ABC-type spermidine putrescine transport system, permease component I
PRtIB026_RS03295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PRtIB026_RS03300	COG0546	phosphoglycolate phosphatase activity
PRtIB026_RS03305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PRtIB026_RS03310	COG3240	lipase activity
PRtIB026_RS03310	COG4625	pathogenesis
PRtIB026_RS03315	COG0512	Glutamine amidotransferase of anthranilate synthase
PRtIB026_RS03320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PRtIB026_RS03325	COG0134	indole-3-glycerol-phosphate synthase activity
PRtIB026_RS03340	COG1765	OsmC-like protein
PRtIB026_RS03355	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PRtIB026_RS03360	COG0537	adenosine 5'-monophosphoramidase activity
PRtIB026_RS03365	COG0300	oxidoreductase activity
PRtIB026_RS03370	COG2070	2-Nitropropane dioxygenase
PRtIB026_RS03375	COG1981	membrane
PRtIB026_RS03380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PRtIB026_RS03385	COG0316	Belongs to the HesB IscA family
PRtIB026_RS03390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PRtIB026_RS03395	COG0739	heme binding
PRtIB026_RS03400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PRtIB026_RS03440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PRtIB026_RS03465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PRtIB026_RS03485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PRtIB026_RS03490	COG0081	regulation of translation
PRtIB026_RS03495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PRtIB026_RS03500	COG0222	ribosome binding
PRtIB026_RS03510	COG0085	RNA polymerase activity
PRtIB026_RS03515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PRtIB026_RS03520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PRtIB026_RS03525	COG0049	tRNA binding
PRtIB026_RS03530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PRtIB026_RS03535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PRtIB026_RS03540	COG0051	transcription antitermination factor activity, RNA binding
PRtIB026_RS03545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PRtIB026_RS03550	COG0088	Forms part of the polypeptide exit tunnel
PRtIB026_RS03555	COG0089	rRNA binding
PRtIB026_RS03560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PRtIB026_RS03565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PRtIB026_RS03570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PRtIB026_RS03575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PRtIB026_RS03580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PRtIB026_RS03585	COG0255	Belongs to the universal ribosomal protein uL29 family
PRtIB026_RS03590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PRtIB026_RS03595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PRtIB026_RS03600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PRtIB026_RS03605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PRtIB026_RS03610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PRtIB026_RS03615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PRtIB026_RS03620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PRtIB026_RS03625	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PRtIB026_RS03630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PRtIB026_RS03635	COG1841	ribosomal large subunit assembly
PRtIB026_RS03640	COG0200	Binds to the 23S rRNA
PRtIB026_RS03650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PRtIB026_RS03655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PRtIB026_RS03660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PRtIB026_RS03665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PRtIB026_RS03670	COG0202	RNA polymerase activity
PRtIB026_RS03675	COG0203	ribosomal protein L17
PRtIB026_RS03680	COG0753	catalase activity
PRtIB026_RS03685	COG2193	ferroxidase activity
PRtIB026_RS03690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PRtIB026_RS03695	COG2814	Major facilitator Superfamily
PRtIB026_RS03700	COG0629	single-stranded DNA binding
PRtIB026_RS03715	COG0437	4 iron, 4 sulfur cluster binding
PRtIB026_RS03720	COG2864	formate dehydrogenase
PRtIB026_RS03725	COG3058	Necessary for formate dehydrogenase activity
PRtIB026_RS03730	COG1921	L-seryl-tRNASec selenium transferase activity
PRtIB026_RS03735	COG3276	selenocysteine insertion sequence binding
PRtIB026_RS03745	COG0252	asparaginase activity
PRtIB026_RS03750	COG1115	amino acid carrier protein
PRtIB026_RS03770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PRtIB026_RS03780	COG2814	Major facilitator Superfamily
PRtIB026_RS03785	COG3047	cAMP biosynthetic process
PRtIB026_RS03800	COG1136	(ABC) transporter
PRtIB026_RS03800	COG0577	efflux transmembrane transporter activity
PRtIB026_RS03815	COG3118	belongs to the thioredoxin family
PRtIB026_RS03820	COG2264	protein methyltransferase activity
PRtIB026_RS03830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PRtIB026_RS03850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PRtIB026_RS03855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PRtIB026_RS03860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PRtIB026_RS03865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PRtIB026_RS03875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PRtIB026_RS03885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PRtIB026_RS03895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PRtIB026_RS03900	COG0142	geranyltranstransferase activity
PRtIB026_RS03905	COG1722	exodeoxyribonuclease VII activity
PRtIB026_RS03910	COG1696	Membrane protein involved in D-alanine export
PRtIB026_RS03925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PRtIB026_RS03930	COG4650	regulator
PRtIB026_RS03940	COG1690	Belongs to the RtcB family
PRtIB026_RS03945	COG3541	Predicted nucleotidyltransferase
PRtIB026_RS03950	COG2819	hydrolase of the alpha beta superfamily
PRtIB026_RS03970	COG3712	iron ion homeostasis
PRtIB026_RS03990	COG3033	Beta-eliminating lyase
PRtIB026_RS04025	COG0475	glutathione-regulated potassium exporter activity
PRtIB026_RS04050	COG1193	negative regulation of DNA recombination
PRtIB026_RS04055	COG0625	glutathione transferase activity
PRtIB026_RS04070	COG1178	ABC-type Fe3 transport system permease component
PRtIB026_RS04090	COG0557	exoribonuclease II activity
PRtIB026_RS04095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PRtIB026_RS04100	COG0360	Binds together with S18 to 16S ribosomal RNA
PRtIB026_RS04105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PRtIB026_RS04115	COG0359	binds to the 23S rRNA
PRtIB026_RS04120	COG0305	Participates in initiation and elongation during chromosome replication
PRtIB026_RS04125	COG1032	radical SAM domain protein
PRtIB026_RS04140	COG0463	Glycosyl transferase, family 2
PRtIB026_RS04155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PRtIB026_RS04160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PRtIB026_RS04190	COG4221	oxidoreductase activity
PRtIB026_RS04200	COG1522	sequence-specific DNA binding
PRtIB026_RS04205	COG0697	spore germination
PRtIB026_RS04210	COG0513	Belongs to the DEAD box helicase family
PRtIB026_RS04220	COG0123	including yeast histone deacetylase and acetoin utilization protein
PRtIB026_RS04235	COG1946	Acyl-CoA thioesterase
PRtIB026_RS04240	COG0546	phosphoglycolate phosphatase activity
PRtIB026_RS04245	COG0604	alcohol dehydrogenase
PRtIB026_RS04245	COG3321	synthase
PRtIB026_RS04260	COG0569	domain protein
PRtIB026_RS04260	COG0189	ligase activity
PRtIB026_RS04310	COG0431	NADPH-dependent FMN reductase
PRtIB026_RS04340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PRtIB026_RS04345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PRtIB026_RS04350	COG0732	type I restriction modification DNA specificity domain
PRtIB026_RS04360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PRtIB026_RS04380	COG4983	Phage plasmid primase, P4 family domain protein
PRtIB026_RS04385	COG0582	viral genome integration into host DNA
PRtIB026_RS04410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PRtIB026_RS04440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PRtIB026_RS04445	COG0023	Translation Initiation Factor
PRtIB026_RS04450	COG1166	arginine decarboxylase activity
PRtIB026_RS04460	COG0534	Mate efflux family protein
PRtIB026_RS04465	COG2373	Large extracellular alpha-helical protein
PRtIB026_RS04475	COG4953	penicillin-binding protein 1C
PRtIB026_RS04515	COG4964	Belongs to the GSP D family
PRtIB026_RS04585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PRtIB026_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS04610	COG2207	Transcriptional regulator
PRtIB026_RS04635	COG2814	Major facilitator Superfamily
PRtIB026_RS04645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PRtIB026_RS04650	COG0300	oxidoreductase activity
PRtIB026_RS04660	COG1309	transcriptional regulator
PRtIB026_RS04705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PRtIB026_RS04710	COG1074	ATP-dependent DNA helicase activity
PRtIB026_RS04715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PRtIB026_RS04725	COG2199	diguanylate cyclase activity
PRtIB026_RS04730	COG2885	chlorophyll binding
PRtIB026_RS04730	COG3047	cAMP biosynthetic process
PRtIB026_RS04760	COG4589	Belongs to the CDS family
PRtIB026_RS04775	COG0671	phosphoesterase, PA-phosphatase related
PRtIB026_RS04775	COG2453	phosphatase
PRtIB026_RS04780	COG2267	carboxylic ester hydrolase activity
PRtIB026_RS04785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PRtIB026_RS04810	COG2249	NAD(P)H dehydrogenase (quinone) activity
PRtIB026_RS04815	COG0583	DNA-binding transcription factor activity
PRtIB026_RS04825	COG0840	transmembrane signaling receptor activity
PRtIB026_RS04830	COG2321	neutral zinc metallopeptidase
PRtIB026_RS04835	COG3485	protocatechuate 3,4-dioxygenase
PRtIB026_RS04845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PRtIB026_RS04850	COG2252	PERMEase
PRtIB026_RS04860	COG1271	oxidase subunit
PRtIB026_RS04865	COG1294	oxidase, subunit
PRtIB026_RS04875	COG2813	Specifically methylates the guanine in position
PRtIB026_RS04890	COG1970	mechanosensitive ion channel activity
PRtIB026_RS04935	COG2233	PERMEase
PRtIB026_RS04945	COG1966	Carbon starvation protein
PRtIB026_RS04950	COG2879	small protein
PRtIB026_RS04955	COG0523	cobalamin synthesis protein
PRtIB026_RS04970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PRtIB026_RS04985	COG0488	(ABC) transporter
PRtIB026_RS04990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PRtIB026_RS04995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PRtIB026_RS05015	COG1067	ATP-dependent peptidase activity
PRtIB026_RS05025	COG2862	Uncharacterized protein family, UPF0114
PRtIB026_RS05035	COG0545	Peptidyl-prolyl cis-trans isomerase
PRtIB026_RS05045	COG2824	Alkylphosphonate utilization operon protein PhnA
PRtIB026_RS05050	COG0142	geranyltranstransferase activity
PRtIB026_RS05055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PRtIB026_RS05060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PRtIB026_RS05065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PRtIB026_RS05070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PRtIB026_RS05075	COG3045	CreA protein
PRtIB026_RS05100	COG0456	acetyltransferase
PRtIB026_RS05120	COG2957	Belongs to the agmatine deiminase family
PRtIB026_RS05135	COG2957	Belongs to the agmatine deiminase family
PRtIB026_RS05145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PRtIB026_RS05190	COG0583	DNA-binding transcription factor activity
PRtIB026_RS05195	COG1380	Effector of murein hydrolase LrgA
PRtIB026_RS05200	COG1346	cytolysis
PRtIB026_RS05205	COG0596	Alpha beta hydrolase
PRtIB026_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS05220	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PRtIB026_RS05225	COG0179	Fumarylacetoacetate (FAA) hydrolase
PRtIB026_RS05250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PRtIB026_RS05255	COG2885	chlorophyll binding
PRtIB026_RS05260	COG0280	phosphate acetyltransferase
PRtIB026_RS05260	COG0857	belongs to the CobB CobQ family
PRtIB026_RS05270	COG1047	Peptidyl-prolyl cis-trans
PRtIB026_RS05275	COG0386	Belongs to the glutathione peroxidase family
PRtIB026_RS05280	COG4772	TonB-dependent receptor
PRtIB026_RS05285	COG3712	iron ion homeostasis
PRtIB026_RS05290	COG1595	DNA-templated transcription, initiation
PRtIB026_RS05325	COG2207	Transcriptional regulator
PRtIB026_RS05325	COG3708	Transcriptional regulator
PRtIB026_RS05330	COG0697	spore germination
PRtIB026_RS05335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRtIB026_RS05340	COG0583	DNA-binding transcription factor activity
PRtIB026_RS05360	COG1566	PFAM secretion protein HlyD family protein
PRtIB026_RS05380	COG0583	DNA-binding transcription factor activity
PRtIB026_RS05400	COG0300	oxidoreductase activity
PRtIB026_RS05410	COG0662	Cupin 2, conserved barrel domain protein
PRtIB026_RS05410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PRtIB026_RS05425	COG1696	Membrane protein involved in D-alanine export
PRtIB026_RS05440	COG3420	alginic acid biosynthetic process
PRtIB026_RS05450	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PRtIB026_RS05460	COG1215	transferase activity, transferring glycosyl groups
PRtIB026_RS05465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PRtIB026_RS05470	COG3022	response to hydroperoxide
PRtIB026_RS05480	COG3781	membrane
PRtIB026_RS05515	COG3012	SEC-C Motif Domain Protein
PRtIB026_RS05535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PRtIB026_RS05540	COG0343	queuine tRNA-ribosyltransferase activity
PRtIB026_RS05545	COG1862	Preprotein translocase
PRtIB026_RS05560	COG3134	Outer membrane lipoprotein
PRtIB026_RS05585	COG1104	cysteine desulfurase activity
PRtIB026_RS05595	COG0316	Belongs to the HesB IscA family
PRtIB026_RS05600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PRtIB026_RS05605	COG0443	Heat shock 70 kDa protein
PRtIB026_RS05610	COG0633	Ferredoxin
PRtIB026_RS05620	COG0105	UTP biosynthetic process
PRtIB026_RS05625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PRtIB026_RS05640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PRtIB026_RS05645	COG0124	histidyl-tRNA synthetase
PRtIB026_RS05660	COG1160	GTP binding
PRtIB026_RS05665	COG0436	Aminotransferase
PRtIB026_RS05670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PRtIB026_RS05680	COG4774	siderophore transport
PRtIB026_RS05685	COG3128	pkhd-type hydroxylase
PRtIB026_RS05695	COG0019	diaminopimelate decarboxylase activity
PRtIB026_RS05710	COG4772	TonB-dependent receptor
PRtIB026_RS05735	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
PRtIB026_RS05745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PRtIB026_RS05770	COG4608	Belongs to the ABC transporter superfamily
PRtIB026_RS05775	COG0444	Belongs to the ABC transporter superfamily
PRtIB026_RS05780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PRtIB026_RS05785	COG0601	transmembrane transport
PRtIB026_RS05790	COG0747	negative chemotaxis
PRtIB026_RS05800	COG0747	negative chemotaxis
PRtIB026_RS05805	COG0747	negative chemotaxis
PRtIB026_RS05820	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PRtIB026_RS05840	COG1113	amino acid transport
PRtIB026_RS05850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PRtIB026_RS05865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PRtIB026_RS05870	COG0154	amidase activity
PRtIB026_RS05875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PRtIB026_RS05880	COG1077	Cell shape determining protein MreB Mrl
PRtIB026_RS05885	COG1792	Involved in formation and maintenance of cell shape
PRtIB026_RS05895	COG0424	maF-like protein
PRtIB026_RS05910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PRtIB026_RS05915	COG0312	modulator of DNA gyrase
PRtIB026_RS05920	COG3028	Belongs to the UPF0307 family
PRtIB026_RS05925	COG0312	modulator of DNA gyrase
PRtIB026_RS05955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PRtIB026_RS05960	COG1660	Displays ATPase and GTPase activities
PRtIB026_RS05970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PRtIB026_RS05975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PRtIB026_RS05980	COG1137	ATPase activity
PRtIB026_RS05985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PRtIB026_RS05995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PRtIB026_RS06005	COG1127	ABC transporter
PRtIB026_RS06010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PRtIB026_RS06015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PRtIB026_RS06035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PRtIB026_RS06040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PRtIB026_RS06045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PRtIB026_RS06050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PRtIB026_RS06065	COG2186	Transcriptional regulator
PRtIB026_RS06080	COG2827	Endonuclease containing a URI domain
PRtIB026_RS06095	COG3081	Nucleoid-associated protein
PRtIB026_RS06105	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PRtIB026_RS06110	COG0525	valine-tRNA ligase activity
PRtIB026_RS06125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PRtIB026_RS06130	COG0795	lipopolysaccharide-transporting ATPase activity
PRtIB026_RS06135	COG0795	lipopolysaccharide-transporting ATPase activity
PRtIB026_RS06145	COG1278	Cold shock
PRtIB026_RS06150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PRtIB026_RS06155	COG1760	l-serine dehydratase
PRtIB026_RS06160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PRtIB026_RS06160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PRtIB026_RS06165	COG0509	glycine decarboxylation via glycine cleavage system
PRtIB026_RS06185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PRtIB026_RS06190	COG2235	arginine
PRtIB026_RS06210	COG2832	Protein of unknown function (DUF454)
PRtIB026_RS06280	COG1175	transmembrane transport
PRtIB026_RS06285	COG0395	ABC-type sugar transport system, permease component
PRtIB026_RS06290	COG3842	ATPase activity
PRtIB026_RS06300	COG0676	glucose-6-phosphate 1-epimerase activity
PRtIB026_RS06305	COG1737	Transcriptional regulator
PRtIB026_RS06320	COG0800	Aldolase
PRtIB026_RS06325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PRtIB026_RS06330	COG0739	heme binding
PRtIB026_RS06335	COG1570	exodeoxyribonuclease VII activity
PRtIB026_RS06360	COG0519	Catalyzes the synthesis of GMP from XMP
PRtIB026_RS06360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PRtIB026_RS06365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PRtIB026_RS06380	COG0590	tRNA wobble adenosine to inosine editing
PRtIB026_RS06385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PRtIB026_RS06390	COG0047	phosphoribosylformylglycinamidine synthase activity
PRtIB026_RS06390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PRtIB026_RS06395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PRtIB026_RS06400	COG1263	PTS System
PRtIB026_RS06400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PRtIB026_RS06400	COG2190	(PTS) system
PRtIB026_RS06415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PRtIB026_RS06420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PRtIB026_RS06445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PRtIB026_RS06450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PRtIB026_RS06490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PRtIB026_RS06580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PRtIB026_RS06585	COG0477	Major facilitator Superfamily
PRtIB026_RS06590	COG4536	flavin adenine dinucleotide binding
PRtIB026_RS06600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PRtIB026_RS06605	COG0228	four-way junction DNA binding
PRtIB026_RS06610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PRtIB026_RS06615	COG0336	Belongs to the RNA methyltransferase TrmD family
PRtIB026_RS06620	COG0335	large ribosomal subunit rRNA binding
PRtIB026_RS06625	COG1607	acyl-coa hydrolase
PRtIB026_RS06630	COG3263	regulation of cellular component size
PRtIB026_RS06635	COG4974	Belongs to the 'phage' integrase family
PRtIB026_RS06670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PRtIB026_RS06705	COG2979	Protein of unknown function (DUF533)
PRtIB026_RS06720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PRtIB026_RS06720	COG0457	Tetratricopeptide repeat
PRtIB026_RS06730	COG0784	Response regulator, receiver
PRtIB026_RS06730	COG0643	Histidine kinase
PRtIB026_RS06730	COG0643	Histidine kinase
PRtIB026_RS06730	COG2198	Histidine kinase
PRtIB026_RS06730	COG0784	Response regulator, receiver
PRtIB026_RS06730	COG2198	Histidine kinase
PRtIB026_RS06735	COG2201	protein-glutamate methylesterase activity
PRtIB026_RS06740	COG5001	Diguanylate cyclase
PRtIB026_RS06740	COG4251	negative regulation of phosphorylation
PRtIB026_RS06740	COG3706	GGDEF domain
PRtIB026_RS06740	COG2203	Gaf domain
PRtIB026_RS06755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PRtIB026_RS06775	COG1073	alpha beta
PRtIB026_RS06785	COG2026	Addiction module toxin, RelE StbE family
PRtIB026_RS06795	COG2885	chlorophyll binding
PRtIB026_RS06810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PRtIB026_RS06815	COG0563	adenylate kinase activity
PRtIB026_RS06850	COG0742	ribosomal rna small subunit methyltransferase
PRtIB026_RS06860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS06875	COG2937	Belongs to the GPAT DAPAT family
PRtIB026_RS06890	COG2226	methyltransferase
PRtIB026_RS06895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PRtIB026_RS06900	COG1215	transferase activity, transferring glycosyl groups
PRtIB026_RS06905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PRtIB026_RS06915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PRtIB026_RS06920	COG2171	N-acyltransferase activity
PRtIB026_RS06925	COG1393	Belongs to the ArsC family
PRtIB026_RS06930	COG0025	NhaP-type Na H and K H
PRtIB026_RS06940	COG0436	Aminotransferase
PRtIB026_RS06945	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PRtIB026_RS06950	COG0024	Methionine aminopeptidase
PRtIB026_RS06955	COG0052	Belongs to the universal ribosomal protein uS2 family
PRtIB026_RS06960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PRtIB026_RS06965	COG0528	UMP kinase activity
PRtIB026_RS06970	COG0233	cytoplasmic translational termination
PRtIB026_RS06975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PRtIB026_RS06985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PRtIB026_RS07005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PRtIB026_RS07010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PRtIB026_RS07015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PRtIB026_RS07020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PRtIB026_RS07025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PRtIB026_RS07035	COG0825	malonyl-CoA metabolic process
PRtIB026_RS07040	COG0037	tRNA processing
PRtIB026_RS07045	COG0504	CTP synthase activity
PRtIB026_RS07050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PRtIB026_RS07055	COG0148	phosphopyruvate hydratase activity
PRtIB026_RS07065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PRtIB026_RS07075	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PRtIB026_RS07080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PRtIB026_RS07085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PRtIB026_RS07090	COG0585	pseudouridine synthase activity
PRtIB026_RS07095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PRtIB026_RS07100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PRtIB026_RS07115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PRtIB026_RS07120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PRtIB026_RS07240	COG3179	chitinase
PRtIB026_RS07260	COG1546	Belongs to the CinA family
PRtIB026_RS07265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PRtIB026_RS07270	COG2137	regulation of response to DNA damage stimulus
PRtIB026_RS07290	COG3148	PFAM DTW domain containing protein
PRtIB026_RS07305	COG0583	DNA-binding transcription factor activity
PRtIB026_RS07320	COG4807	Protein conserved in bacteria
PRtIB026_RS07335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PRtIB026_RS07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS07340	COG2205	protein histidine kinase activity
PRtIB026_RS07345	COG2205	protein histidine kinase activity
PRtIB026_RS07345	COG0784	Response regulator, receiver
PRtIB026_RS07355	COG1716	ATPase activity
PRtIB026_RS07355	COG5001	Diguanylate cyclase
PRtIB026_RS07380	COG3188	usher protein
PRtIB026_RS07385	COG3121	Chaperone
PRtIB026_RS07395	COG3158	transport of potassium into the cell
PRtIB026_RS07425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PRtIB026_RS07435	COG0442	prolyl-tRNA aminoacylation
PRtIB026_RS07450	COG2900	Belongs to the SlyX family
PRtIB026_RS07460	COG0783	Belongs to the Dps family
PRtIB026_RS07475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PRtIB026_RS07480	COG0217	transcriptional regulatory protein
PRtIB026_RS07485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PRtIB026_RS07490	COG0632	four-way junction helicase activity
PRtIB026_RS07495	COG2255	four-way junction helicase activity
PRtIB026_RS07520	COG0823	Involved in the tonB-independent uptake of proteins
PRtIB026_RS07525	COG2885	chlorophyll binding
PRtIB026_RS07530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PRtIB026_RS07535	COG0602	queuosine metabolic process
PRtIB026_RS07540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PRtIB026_RS07550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS07555	COG0833	amino acid
PRtIB026_RS07560	COG2194	sulfuric ester hydrolase activity
PRtIB026_RS07575	COG0840	transmembrane signaling receptor activity
PRtIB026_RS07580	COG0531	amino acid
PRtIB026_RS07590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PRtIB026_RS07600	COG0425	Belongs to the sulfur carrier protein TusA family
PRtIB026_RS07610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PRtIB026_RS07620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PRtIB026_RS07625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PRtIB026_RS07630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PRtIB026_RS07635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PRtIB026_RS07680	COG3657	addiction module killer protein
PRtIB026_RS07690	COG0579	oxidoreductase
PRtIB026_RS07695	COG0640	Transcriptional regulator
PRtIB026_RS07700	COG1902	pentaerythritol trinitrate reductase activity
PRtIB026_RS07705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS07715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PRtIB026_RS07720	COG3938	Belongs to the proline racemase family
PRtIB026_RS07725	COG0531	amino acid
PRtIB026_RS07740	COG0521	Mo-molybdopterin cofactor biosynthetic process
PRtIB026_RS07745	COG3781	membrane
PRtIB026_RS07750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PRtIB026_RS07755	COG0243	molybdopterin cofactor binding
PRtIB026_RS07760	COG1522	sequence-specific DNA binding
PRtIB026_RS07765	COG0626	cystathionine gamma-synthase activity
PRtIB026_RS07790	COG3100	YcgL domain-containing protein
PRtIB026_RS07795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PRtIB026_RS07805	COG2983	Belongs to the UPF0260 family
PRtIB026_RS07845	COG0121	glutamine amidotransferase
PRtIB026_RS07860	COG2814	Major facilitator Superfamily
PRtIB026_RS07865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PRtIB026_RS07870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PRtIB026_RS07875	COG1984	allophanate hydrolase subunit 2
PRtIB026_RS07950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PRtIB026_RS07970	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PRtIB026_RS08000	COG0242	peptide deformylase activity
PRtIB026_RS08015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PRtIB026_RS08045	COG3795	YCII-related domain
PRtIB026_RS08050	COG4941	Belongs to the sigma-70 factor family
PRtIB026_RS08055	COG2030	dehydratase
PRtIB026_RS08060	COG2267	carboxylic ester hydrolase activity
PRtIB026_RS08065	COG0318	PFAM AMP-dependent synthetase and ligase
PRtIB026_RS08070	COG0318	PFAM AMP-dependent synthetase and ligase
PRtIB026_RS08080	COG0174	glutamine synthetase
PRtIB026_RS08100	COG1643	Atp-dependent helicase
PRtIB026_RS08110	COG2188	Transcriptional regulator
PRtIB026_RS08120	COG1132	(ABC) transporter
PRtIB026_RS08130	COG2267	carboxylic ester hydrolase activity
PRtIB026_RS08145	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PRtIB026_RS08155	COG0583	DNA-binding transcription factor activity
PRtIB026_RS08160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PRtIB026_RS08180	COG0668	transmembrane transport
PRtIB026_RS08185	COG0513	Belongs to the DEAD box helicase family
PRtIB026_RS08210	COG3210	domain, Protein
PRtIB026_RS08220	COG3210	domain, Protein
PRtIB026_RS08225	COG3210	domain, Protein
PRtIB026_RS08290	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PRtIB026_RS08295	COG3657	addiction module killer protein
PRtIB026_RS08305	COG0583	DNA-binding transcription factor activity
PRtIB026_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS08355	COG2832	Protein of unknown function (DUF454)
PRtIB026_RS08390	COG2207	Transcriptional regulator
PRtIB026_RS08415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PRtIB026_RS08420	COG0778	Nitroreductase
PRtIB026_RS08435	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS08445	COG2350	Protein conserved in bacteria
PRtIB026_RS08450	COG2917	probably involved in intracellular septation
PRtIB026_RS08455	COG0613	PHP domain protein
PRtIB026_RS08460	COG0009	L-threonylcarbamoyladenylate synthase
PRtIB026_RS08470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PRtIB026_RS08480	COG1113	amino acid transport
PRtIB026_RS08490	COG0247	lactate metabolic process
PRtIB026_RS08490	COG0277	FAD linked oxidase domain protein
PRtIB026_RS08505	COG2154	pterin-4-alpha-carbinolamine dehydratase
PRtIB026_RS08525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PRtIB026_RS08530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS08535	COG4215	(ABC) transporter
PRtIB026_RS08555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PRtIB026_RS08570	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS08575	COG3724	N-succinylarginine dihydrolase activity
PRtIB026_RS08585	COG2988	succinylglutamate desuccinylase activity
PRtIB026_RS08590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PRtIB026_RS08595	COG0527	aspartate kinase activity
PRtIB026_RS08600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PRtIB026_RS08630	COG2239	Acts as a magnesium transporter
PRtIB026_RS08650	COG3135	benzoate transporter
PRtIB026_RS08655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PRtIB026_RS08665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PRtIB026_RS08675	COG0022	dehydrogenase e1 component
PRtIB026_RS08680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PRtIB026_RS08685	COG1522	sequence-specific DNA binding
PRtIB026_RS08695	COG0477	Major facilitator Superfamily
PRtIB026_RS08700	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PRtIB026_RS08725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PRtIB026_RS08735	COG1815	bacterial-type flagellum-dependent cell motility
PRtIB026_RS08750	COG1749	Flagellar hook protein flgE
PRtIB026_RS08765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS08785	COG4787	bacterial-type flagellum-dependent cell motility
PRtIB026_RS08800	COG1706	bacterial-type flagellum-dependent cell motility
PRtIB026_RS08810	COG1256	bacterial-type flagellum assembly
PRtIB026_RS08820	COG1216	Glycosyl transferase, family 2
PRtIB026_RS08820	COG0438	transferase activity, transferring glycosyl groups
PRtIB026_RS08835	COG4106	trans-aconitate 2-methyltransferase activity
PRtIB026_RS08865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PRtIB026_RS08870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PRtIB026_RS08880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PRtIB026_RS08910	COG1677	Flagellar hook-basal body complex protein FliE
PRtIB026_RS08935	COG2882	bacterial-type flagellum organization
PRtIB026_RS08945	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS08985	COG1987	bacterial-type flagellum assembly
PRtIB026_RS09015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PRtIB026_RS09040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PRtIB026_RS09045	COG0643	Histidine kinase
PRtIB026_RS09045	COG2198	Histidine kinase
PRtIB026_RS09045	COG0784	Response regulator, receiver
PRtIB026_RS09050	COG2201	protein-glutamate methylesterase activity
PRtIB026_RS09055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PRtIB026_RS09060	COG1360	Flagellar Motor Protein
PRtIB026_RS09065	COG1192	Involved in chromosome partitioning
PRtIB026_RS09075	COG0835	chemotaxis
PRtIB026_RS09095	COG2257	FlhB HrpN YscU SpaS Family
PRtIB026_RS09105	COG4133	protoheme IX ABC transporter activity
PRtIB026_RS09125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PRtIB026_RS09130	COG1138	Cytochrome C-type biogenesis protein
PRtIB026_RS09225	COG1953	Uracil, thiamine, allantoin
PRtIB026_RS09230	COG1522	sequence-specific DNA binding
PRtIB026_RS09240	COG0435	Glutathione S-transferase
PRtIB026_RS09245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PRtIB026_RS09255	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS09265	COG0367	asparagine synthase
PRtIB026_RS09270	COG1024	Enoyl-CoA hydratase
PRtIB026_RS09275	COG3425	synthase
PRtIB026_RS09290	COG0583	DNA-binding transcription factor activity
PRtIB026_RS09305	COG1538	Outer membrane efflux protein
PRtIB026_RS09310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PRtIB026_RS09315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS09325	COG0116	Belongs to the methyltransferase superfamily
PRtIB026_RS09325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PRtIB026_RS09335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PRtIB026_RS09345	COG0469	pyruvate kinase activity
PRtIB026_RS09355	COG2084	Dehydrogenase
PRtIB026_RS09360	COG3622	Belongs to the hyi family
PRtIB026_RS09365	COG3960	tartronate-semialdehyde synthase activity
PRtIB026_RS09380	COG2354	Protein conserved in bacteria
PRtIB026_RS09395	COG2233	PERMEase
PRtIB026_RS09405	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PRtIB026_RS09425	COG2252	PERMEase
PRtIB026_RS09435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PRtIB026_RS09440	COG0402	S-adenosylhomocysteine deaminase activity
PRtIB026_RS09470	COG3115	cell septum assembly
PRtIB026_RS09475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PRtIB026_RS09515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PRtIB026_RS09520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PRtIB026_RS09525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PRtIB026_RS09530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PRtIB026_RS09535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PRtIB026_RS09565	COG0348	domain, Protein
PRtIB026_RS09570	COG2010	Cytochrome c
PRtIB026_RS09585	COG3278	Belongs to the heme-copper respiratory oxidase family
PRtIB026_RS09590	COG2010	Cytochrome c
PRtIB026_RS09605	COG3278	Belongs to the heme-copper respiratory oxidase family
PRtIB026_RS09615	COG3123	guanosine phosphorylase activity
PRtIB026_RS09640	COG3209	COG3209 Rhs family protein
PRtIB026_RS09675	COG0642	Histidine kinase
PRtIB026_RS09700	COG0577	efflux transmembrane transporter activity
PRtIB026_RS09700	COG1136	(ABC) transporter
PRtIB026_RS09705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS09730	COG2944	sequence-specific DNA binding
PRtIB026_RS09765	COG2885	chlorophyll binding
PRtIB026_RS09770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PRtIB026_RS09795	COG2009	succinate dehydrogenase
PRtIB026_RS09800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PRtIB026_RS09805	COG1053	succinate dehydrogenase
PRtIB026_RS09825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PRtIB026_RS09830	COG0045	succinate-CoA ligase (ADP-forming) activity
PRtIB026_RS09865	COG0326	Molecular chaperone. Has ATPase activity
PRtIB026_RS09880	COG1741	Belongs to the pirin family
PRtIB026_RS09900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PRtIB026_RS09905	COG4999	Histidine kinase
PRtIB026_RS09905	COG3850	Histidine kinase
PRtIB026_RS09905	COG3437	response regulator, receiver
PRtIB026_RS09905	COG2205	protein histidine kinase activity
PRtIB026_RS09920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PRtIB026_RS09945	COG0596	Alpha beta hydrolase
PRtIB026_RS09955	COG0628	permease
PRtIB026_RS09970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PRtIB026_RS09980	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PRtIB026_RS09985	COG2205	protein histidine kinase activity
PRtIB026_RS09990	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS09995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS09995	COG2205	protein histidine kinase activity
PRtIB026_RS10000	COG2197	response regulator
PRtIB026_RS10015	COG3188	usher protein
PRtIB026_RS10020	COG3121	Chaperone
PRtIB026_RS10050	COG0583	DNA-binding transcription factor activity
PRtIB026_RS10070	COG0583	DNA-binding transcription factor activity
PRtIB026_RS10080	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PRtIB026_RS10100	COG2271	Major facilitator Superfamily
PRtIB026_RS10120	COG2197	response regulator
PRtIB026_RS10125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PRtIB026_RS10145	COG2197	response regulator
PRtIB026_RS10150	COG0531	amino acid
PRtIB026_RS10185	COG4172	Belongs to the ABC transporter superfamily
PRtIB026_RS10195	COG4174	ABC transporter (Permease)
PRtIB026_RS10205	COG4166	transmembrane transport
PRtIB026_RS10210	COG0741	lytic transglycosylase activity
PRtIB026_RS10210	COG1388	LysM domain
PRtIB026_RS10215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PRtIB026_RS10225	COG0328	RNA-DNA hybrid ribonuclease activity
PRtIB026_RS10245	COG0431	NADPH-dependent FMN reductase
PRtIB026_RS10250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PRtIB026_RS10255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PRtIB026_RS10260	COG0583	DNA-binding transcription factor activity
PRtIB026_RS10265	COG2207	Transcriptional regulator
PRtIB026_RS10275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PRtIB026_RS10285	COG0183	Belongs to the thiolase family
PRtIB026_RS10290	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS10295	COG1024	Enoyl-CoA hydratase
PRtIB026_RS10335	COG1320	monovalent cation:proton antiporter activity
PRtIB026_RS10340	COG2212	antiporter activity
PRtIB026_RS10350	COG0651	ATP synthesis coupled electron transport
PRtIB026_RS10355	COG1006	Multisubunit Na H antiporter MnhC subunit
PRtIB026_RS10360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PRtIB026_RS10360	COG2111	Na H antiporter
PRtIB026_RS10375	COG1335	isochorismatase
PRtIB026_RS10445	COG0589	response to stress
PRtIB026_RS10475	COG0583	DNA-binding transcription factor activity
PRtIB026_RS10485	COG0010	Belongs to the arginase family
PRtIB026_RS10495	COG2133	pyrroloquinoline quinone binding
PRtIB026_RS10500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PRtIB026_RS10580	COG4792	protein secretion
PRtIB026_RS10585	COG4791	protein targeting
PRtIB026_RS10590	COG4794	Type iii secretion
PRtIB026_RS10595	COG4790	Type iii secretion
PRtIB026_RS10640	COG0457	Tetratricopeptide repeat
PRtIB026_RS10645	COG4789	Type iii secretion
PRtIB026_RS10675	COG1238	metal cluster binding
PRtIB026_RS10695	COG0826	peptidase U32
PRtIB026_RS10700	COG0628	permease
PRtIB026_RS10710	COG1007	ATP synthesis coupled electron transport
PRtIB026_RS10725	COG0713	ATP synthesis coupled electron transport
PRtIB026_RS10735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PRtIB026_RS10740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PRtIB026_RS10745	COG1034	ATP synthesis coupled electron transport
PRtIB026_RS10760	COG0649	NAD binding
PRtIB026_RS10760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PRtIB026_RS10765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PRtIB026_RS10770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PRtIB026_RS10790	COG0659	secondary active sulfate transmembrane transporter activity
PRtIB026_RS10795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PRtIB026_RS10810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PRtIB026_RS10825	COG0625	glutathione transferase activity
PRtIB026_RS10830	COG0306	phosphate transporter
PRtIB026_RS10870	COG1696	Membrane protein involved in D-alanine export
PRtIB026_RS10910	COG0322	excinuclease ABC activity
PRtIB026_RS11045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PRtIB026_RS11050	COG1116	anion transmembrane transporter activity
PRtIB026_RS11055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS11060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS11070	COG3011	Protein conserved in bacteria
PRtIB026_RS11085	COG1944	ATP diphosphatase activity
PRtIB026_RS11100	COG3220	belongs to the UPF0276 family
PRtIB026_RS11110	COG1595	DNA-templated transcription, initiation
PRtIB026_RS11125	COG5000	phosphorelay sensor kinase activity
PRtIB026_RS11125	COG5002	protein histidine kinase activity
PRtIB026_RS11130	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS11140	COG0438	transferase activity, transferring glycosyl groups
PRtIB026_RS11150	COG1953	Uracil, thiamine, allantoin
PRtIB026_RS11160	COG0493	'glutamate synthase
PRtIB026_RS11170	COG0583	DNA-binding transcription factor activity
PRtIB026_RS11225	COG2814	Major facilitator Superfamily
PRtIB026_RS11235	COG1309	transcriptional regulator
PRtIB026_RS11240	COG1309	transcriptional regulator
PRtIB026_RS11275	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PRtIB026_RS11280	COG1024	Enoyl-CoA hydratase
PRtIB026_RS11285	COG2816	NAD+ diphosphatase activity
PRtIB026_RS11290	COG0730	response to heat
PRtIB026_RS11295	COG0174	glutamine synthetase
PRtIB026_RS11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS11315	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PRtIB026_RS11320	COG2153	protein acetylation
PRtIB026_RS11325	COG2850	peptidyl-arginine hydroxylation
PRtIB026_RS11335	COG2915	High frequency lysogenization protein hflD homolog
PRtIB026_RS11340	COG0482	sulfurtransferase activity
PRtIB026_RS11360	COG1278	Cold shock
PRtIB026_RS11365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PRtIB026_RS11370	COG0542	response to heat
PRtIB026_RS11375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PRtIB026_RS11380	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PRtIB026_RS11385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PRtIB026_RS11390	COG1674	ftsk spoiiie
PRtIB026_RS11395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PRtIB026_RS11400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PRtIB026_RS11405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PRtIB026_RS11410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PRtIB026_RS11415	COG1648	precorrin-2 dehydrogenase activity
PRtIB026_RS11415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PRtIB026_RS11420	COG0435	Glutathione S-transferase
PRtIB026_RS11425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PRtIB026_RS11430	COG2920	part of a sulfur-relay system
PRtIB026_RS11450	COG2233	PERMEase
PRtIB026_RS11550	COG0596	Alpha beta hydrolase
PRtIB026_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS11595	COG2199	diguanylate cyclase activity
PRtIB026_RS11600	COG0471	metal ion transport
PRtIB026_RS11600	COG0490	domain, Protein
PRtIB026_RS11620	COG5001	Diguanylate cyclase
PRtIB026_RS11625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PRtIB026_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS11650	COG0616	signal peptide processing
PRtIB026_RS11715	COG2259	Doxx family
PRtIB026_RS11735	COG4191	Histidine kinase
PRtIB026_RS11735	COG0784	Response regulator, receiver
PRtIB026_RS11740	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PRtIB026_RS11745	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS11750	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PRtIB026_RS11760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PRtIB026_RS11795	COG2863	cytochrome
PRtIB026_RS11800	COG3258	Cytochrome c
PRtIB026_RS11820	COG3634	alkyl hydroperoxide reductase activity
PRtIB026_RS11825	COG2814	Major facilitator Superfamily
PRtIB026_RS11845	COG4774	siderophore transport
PRtIB026_RS11855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PRtIB026_RS11865	COG2873	o-acetylhomoserine
PRtIB026_RS11870	COG1999	signal sequence binding
PRtIB026_RS11890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PRtIB026_RS11910	COG0583	DNA-binding transcription factor activity
PRtIB026_RS11920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS11925	COG0217	transcriptional regulatory protein
PRtIB026_RS11930	COG0583	DNA-binding transcription factor activity
PRtIB026_RS11935	COG0076	glutamate decarboxylase activity
PRtIB026_RS11940	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PRtIB026_RS11970	COG0625	glutathione transferase activity
PRtIB026_RS12025	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12030	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PRtIB026_RS12050	COG4106	trans-aconitate 2-methyltransferase activity
PRtIB026_RS12055	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PRtIB026_RS12110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PRtIB026_RS12145	COG5001	Diguanylate cyclase
PRtIB026_RS12175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PRtIB026_RS12180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS12215	COG2259	Doxx family
PRtIB026_RS12240	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12245	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12255	COG0417	DNA replication proofreading
PRtIB026_RS12280	COG3220	belongs to the UPF0276 family
PRtIB026_RS12295	COG0019	diaminopimelate decarboxylase activity
PRtIB026_RS12330	COG0625	glutathione transferase activity
PRtIB026_RS12340	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12370	COG2010	Cytochrome c
PRtIB026_RS12375	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PRtIB026_RS12375	COG3608	succinylglutamate desuccinylase aspartoacylase
PRtIB026_RS12405	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12410	COG1760	l-serine dehydratase
PRtIB026_RS12415	COG0814	amino acid
PRtIB026_RS12450	COG0174	glutamine synthetase
PRtIB026_RS12460	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS12465	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12485	COG0826	peptidase U32
PRtIB026_RS12500	COG2384	SAM-dependent methyltransferase
PRtIB026_RS12505	COG2271	Major facilitator Superfamily
PRtIB026_RS12515	COG0583	DNA-binding transcription factor activity
PRtIB026_RS12535	COG2226	methyltransferase
PRtIB026_RS12565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PRtIB026_RS12570	COG1121	(ABC) transporter
PRtIB026_RS12640	COG1609	Transcriptional regulator
PRtIB026_RS12650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PRtIB026_RS12660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRtIB026_RS12680	COG4991	sh3 domain protein
PRtIB026_RS12685	COG1611	Belongs to the LOG family
PRtIB026_RS12700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PRtIB026_RS12740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS12770	COG1396	sequence-specific DNA binding
PRtIB026_RS12770	COG1917	Cupin 2, conserved barrel domain protein
PRtIB026_RS12790	COG1595	DNA-templated transcription, initiation
PRtIB026_RS12855	COG2814	Major facilitator Superfamily
PRtIB026_RS12870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PRtIB026_RS12905	COG0768	penicillin binding
PRtIB026_RS12925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PRtIB026_RS12965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PRtIB026_RS12970	COG0174	glutamine synthetase
PRtIB026_RS12985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PRtIB026_RS13020	COG1595	DNA-templated transcription, initiation
PRtIB026_RS13040	COG0456	acetyltransferase
PRtIB026_RS13040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PRtIB026_RS13050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PRtIB026_RS13060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS13075	COG3712	iron ion homeostasis
PRtIB026_RS13110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PRtIB026_RS13130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PRtIB026_RS13155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PRtIB026_RS13165	COG0439	Biotin carboxylase
PRtIB026_RS13180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS13185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PRtIB026_RS13190	COG0625	glutathione transferase activity
PRtIB026_RS13285	COG1132	(ABC) transporter
PRtIB026_RS13330	COG0318	PFAM AMP-dependent synthetase and ligase
PRtIB026_RS13340	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS13350	COG2197	response regulator
PRtIB026_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS13375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PRtIB026_RS13390	COG4221	oxidoreductase activity
PRtIB026_RS13400	COG1366	Belongs to the anti-sigma-factor antagonist family
PRtIB026_RS13405	COG0789	Transcriptional regulator
PRtIB026_RS13410	COG0039	L-malate dehydrogenase activity
PRtIB026_RS13450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PRtIB026_RS13460	COG0604	alcohol dehydrogenase
PRtIB026_RS13460	COG3321	synthase
PRtIB026_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS13535	COG0534	Mate efflux family protein
PRtIB026_RS13545	COG0583	DNA-binding transcription factor activity
PRtIB026_RS13550	COG2814	Major facilitator Superfamily
PRtIB026_RS13555	COG1280	lysine exporter protein (LysE YggA)
PRtIB026_RS13570	COG1104	cysteine desulfurase activity
PRtIB026_RS13595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PRtIB026_RS13600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PRtIB026_RS13600	COG0316	Belongs to the HesB IscA family
PRtIB026_RS13605	COG1999	signal sequence binding
PRtIB026_RS13625	COG2207	Transcriptional regulator
PRtIB026_RS13645	COG0656	L-ascorbic acid biosynthetic process
PRtIB026_RS13655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PRtIB026_RS13665	COG2031	fatty acid transporter
PRtIB026_RS13675	COG3210	domain, Protein
PRtIB026_RS13685	COG3210	domain, Protein
PRtIB026_RS13830	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
PRtIB026_RS13945	COG1216	Glycosyl transferase, family 2
PRtIB026_RS13955	COG0438	transferase activity, transferring glycosyl groups
PRtIB026_RS13995	COG4774	siderophore transport
PRtIB026_RS14000	COG3217	Mosc domain protein beta barrel domain protein
PRtIB026_RS14000	COG0633	Ferredoxin
PRtIB026_RS14030	COG0477	Major facilitator Superfamily
PRtIB026_RS14075	COG0346	lactoylglutathione lyase activity
PRtIB026_RS14080	COG1414	Transcriptional regulator
PRtIB026_RS14085	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS14095	COG2205	protein histidine kinase activity
PRtIB026_RS14095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS14100	COG2197	response regulator
PRtIB026_RS14105	COG3813	Protein conserved in bacteria
PRtIB026_RS14155	COG2204	response regulator
PRtIB026_RS14205	COG0840	transmembrane signaling receptor activity
PRtIB026_RS14210	COG1968	undecaprenyl-diphosphatase activity
PRtIB026_RS14245	COG0210	DNA helicase
PRtIB026_RS14265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PRtIB026_RS14270	COG1116	anion transmembrane transporter activity
PRtIB026_RS14275	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS14280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRtIB026_RS14290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PRtIB026_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS14360	COG3433	isochorismatase activity
PRtIB026_RS14360	COG1535	isochorismatase
PRtIB026_RS14365	COG1021	2,3-dihydroxybenzoate-AMP ligase
PRtIB026_RS14395	COG2375	cellular response to nickel ion
PRtIB026_RS14395	COG1132	(ABC) transporter
PRtIB026_RS14400	COG1132	(ABC) transporter
PRtIB026_RS14405	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PRtIB026_RS14410	COG4605	iron ion homeostasis
PRtIB026_RS14415	COG4604	ABC transporter, ATP-binding protein
PRtIB026_RS14420	COG4607	ABC-type enterochelin transport system periplasmic component
PRtIB026_RS14425	COG4774	siderophore transport
PRtIB026_RS14435	COG0840	transmembrane signaling receptor activity
PRtIB026_RS14485	COG0300	oxidoreductase activity
PRtIB026_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS14485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PRtIB026_RS14485	COG0318	PFAM AMP-dependent synthetase and ligase
PRtIB026_RS14485	COG3321	synthase
PRtIB026_RS14490	COG0318	PFAM AMP-dependent synthetase and ligase
PRtIB026_RS14530	COG0583	DNA-binding transcription factor activity
PRtIB026_RS14535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PRtIB026_RS14565	COG1566	PFAM secretion protein HlyD family protein
PRtIB026_RS14605	COG1595	DNA-templated transcription, initiation
PRtIB026_RS14650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PRtIB026_RS14655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PRtIB026_RS14660	COG4166	transmembrane transport
PRtIB026_RS14665	COG4174	ABC transporter (Permease)
PRtIB026_RS14670	COG4239	(ABC) transporter, permease
PRtIB026_RS14675	COG3290	protein histidine kinase activity
PRtIB026_RS14675	COG3829	transcription factor binding
PRtIB026_RS14680	COG2610	gluconate transmembrane transporter activity
PRtIB026_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS14690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PRtIB026_RS14695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PRtIB026_RS14725	COG2135	peptidase activity
PRtIB026_RS14745	COG3179	chitinase
PRtIB026_RS14955	COG1280	lysine exporter protein (LysE YggA)
PRtIB026_RS14995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PRtIB026_RS15000	COG1247	-acetyltransferase
PRtIB026_RS15040	COG2135	peptidase activity
PRtIB026_RS15055	COG0488	(ABC) transporter
PRtIB026_RS15070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PRtIB026_RS15090	COG0583	DNA-binding transcription factor activity
PRtIB026_RS15105	COG3327	negative regulation of DNA-templated transcription, initiation
PRtIB026_RS15115	COG1024	Enoyl-CoA hydratase
PRtIB026_RS15120	COG1024	Enoyl-CoA hydratase
PRtIB026_RS15130	COG2050	protein possibly involved in aromatic compounds catabolism
PRtIB026_RS15135	COG0183	Belongs to the thiolase family
PRtIB026_RS15145	COG3396	Phenylacetate-CoA oxygenase
PRtIB026_RS15150	COG3460	Phenylacetate-CoA oxygenase
PRtIB026_RS15155	COG3396	Phenylacetate-CoA oxygenase
PRtIB026_RS15165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PRtIB026_RS15185	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS15185	COG2030	dehydratase
PRtIB026_RS15230	COG3568	Endonuclease Exonuclease Phosphatase
PRtIB026_RS15235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PRtIB026_RS15290	COG3729	General stress protein
PRtIB026_RS15305	COG1846	Transcriptional regulator
PRtIB026_RS15325	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS15330	COG3384	dioxygenase
PRtIB026_RS15340	COG3971	2-oxopent-4-enoate hydratase activity
PRtIB026_RS15355	COG5001	Diguanylate cyclase
PRtIB026_RS15355	COG4251	negative regulation of phosphorylation
PRtIB026_RS15355	COG2203	Gaf domain
PRtIB026_RS15355	COG3706	GGDEF domain
PRtIB026_RS15360	COG0583	DNA-binding transcription factor activity
PRtIB026_RS15405	COG2165	general secretion pathway protein
PRtIB026_RS15410	COG4796	Type ii and iii secretion system protein
PRtIB026_RS15435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PRtIB026_RS15440	COG2204	response regulator
PRtIB026_RS15480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PRtIB026_RS15505	COG3485	protocatechuate 3,4-dioxygenase
PRtIB026_RS15510	COG4829	muconolactone delta-isomerase
PRtIB026_RS15515	COG4948	Mandelate Racemase Muconate Lactonizing
PRtIB026_RS15520	COG2814	Major facilitator Superfamily
PRtIB026_RS15550	COG1609	Transcriptional regulator
PRtIB026_RS15555	COG3265	gluconokinase activity
PRtIB026_RS15580	COG2204	response regulator
PRtIB026_RS15585	COG5002	protein histidine kinase activity
PRtIB026_RS15590	COG5002	protein histidine kinase activity
PRtIB026_RS15595	COG1196	nuclear chromosome segregation
PRtIB026_RS15595	COG0741	lytic transglycosylase activity
PRtIB026_RS15595	COG0739	heme binding
PRtIB026_RS15605	COG1459	type II secretion system
PRtIB026_RS15610	COG3706	GGDEF domain
PRtIB026_RS15615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PRtIB026_RS15680	COG2258	MOSC domain
PRtIB026_RS15700	COG1942	4-Oxalocrotonate Tautomerase
PRtIB026_RS15705	COG2205	protein histidine kinase activity
PRtIB026_RS15705	COG2198	Histidine kinase
PRtIB026_RS15705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS15705	COG0784	Response regulator, receiver
PRtIB026_RS15710	COG0784	Response regulator, receiver
PRtIB026_RS15710	COG2205	protein histidine kinase activity
PRtIB026_RS15710	COG5002	protein histidine kinase activity
PRtIB026_RS15720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PRtIB026_RS15750	COG1959	2 iron, 2 sulfur cluster binding
PRtIB026_RS15770	COG4191	Histidine kinase
PRtIB026_RS15770	COG0784	Response regulator, receiver
PRtIB026_RS15780	COG1280	lysine exporter protein (LysE YggA)
PRtIB026_RS15800	COG2056	Na+-H+ antiporter family
PRtIB026_RS15805	COG0840	transmembrane signaling receptor activity
PRtIB026_RS15815	COG4176	ABC-type proline glycine betaine transport system permease component
PRtIB026_RS15825	COG0583	DNA-binding transcription factor activity
PRtIB026_RS15835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PRtIB026_RS15840	COG0830	nickel cation binding
PRtIB026_RS15850	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PRtIB026_RS15855	COG0804	urea catabolic process
PRtIB026_RS15860	COG0832	Belongs to the urease beta subunit family
PRtIB026_RS15865	COG0831	urea catabolic process
PRtIB026_RS15870	COG0829	nickel cation binding
PRtIB026_RS15885	COG0488	(ABC) transporter
PRtIB026_RS15900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PRtIB026_RS15905	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS15915	COG0215	cysteine-tRNA ligase activity
PRtIB026_RS15920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PRtIB026_RS15930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PRtIB026_RS15935	COG2366	antibiotic biosynthetic process
PRtIB026_RS15965	COG0367	asparagine synthase
PRtIB026_RS15985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
PRtIB026_RS16055	COG0587	DNA-directed DNA polymerase activity
PRtIB026_RS16100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PRtIB026_RS16125	COG2771	luxR family
PRtIB026_RS16135	COG0601	transmembrane transport
PRtIB026_RS16140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PRtIB026_RS16150	COG4608	Belongs to the ABC transporter superfamily
PRtIB026_RS16190	COG0183	Belongs to the thiolase family
PRtIB026_RS16195	COG1250	3-hydroxyacyl-CoA dehydrogenase
PRtIB026_RS16230	COG0814	amino acid
PRtIB026_RS16275	COG1126	abc transporter atp-binding protein
PRtIB026_RS16285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PRtIB026_RS16325	COG0454	-acetyltransferase
PRtIB026_RS16330	COG1686	Belongs to the peptidase S11 family
PRtIB026_RS16350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PRtIB026_RS16355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PRtIB026_RS16365	COG2721	sulfolactate sulfo-lyase activity
PRtIB026_RS16370	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS16375	COG2186	Transcriptional regulator
PRtIB026_RS16380	COG2207	Transcriptional regulator
PRtIB026_RS16410	COG0277	FAD linked oxidase domain protein
PRtIB026_RS16415	COG0247	lactate metabolic process
PRtIB026_RS16430	COG2807	transmembrane transport
PRtIB026_RS16435	COG0590	tRNA wobble adenosine to inosine editing
PRtIB026_RS16440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PRtIB026_RS16455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS16460	COG4215	(ABC) transporter
PRtIB026_RS16480	COG1737	Transcriptional regulator
PRtIB026_RS16485	COG0583	DNA-binding transcription factor activity
PRtIB026_RS16490	COG2814	Major facilitator Superfamily
PRtIB026_RS16535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS16555	COG0531	amino acid
PRtIB026_RS16570	COG0789	Transcriptional regulator
PRtIB026_RS16580	COG1285	pathogenesis
PRtIB026_RS16585	COG0348	domain, Protein
PRtIB026_RS16600	COG4191	Histidine kinase
PRtIB026_RS16600	COG0784	Response regulator, receiver
PRtIB026_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS16610	COG2814	Major facilitator Superfamily
PRtIB026_RS16615	COG1566	PFAM secretion protein HlyD family protein
PRtIB026_RS16620	COG1846	Transcriptional regulator
PRtIB026_RS16625	COG3415	Transposase
PRtIB026_RS16625	COG2801	Transposase and inactivated derivatives
PRtIB026_RS16630	COG1136	(ABC) transporter
PRtIB026_RS16630	COG0577	efflux transmembrane transporter activity
PRtIB026_RS16635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS16665	COG0784	Response regulator, receiver
PRtIB026_RS16665	COG4191	Histidine kinase
PRtIB026_RS16685	COG2200	EAL domain
PRtIB026_RS16695	COG1253	flavin adenine dinucleotide binding
PRtIB026_RS16705	COG2207	Transcriptional regulator
PRtIB026_RS16710	COG1396	sequence-specific DNA binding
PRtIB026_RS16715	COG0235	Class ii aldolase
PRtIB026_RS16720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PRtIB026_RS16725	COG1929	Belongs to the glycerate kinase type-1 family
PRtIB026_RS16730	COG3835	regulator
PRtIB026_RS16735	COG2271	Major facilitator Superfamily
PRtIB026_RS16755	COG2169	Transcriptional regulator
PRtIB026_RS16760	COG3469	chitinase activity
PRtIB026_RS16805	COG0318	PFAM AMP-dependent synthetase and ligase
PRtIB026_RS16825	COG0583	DNA-binding transcription factor activity
PRtIB026_RS16860	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS16865	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS16895	COG2837	iron assimilation
PRtIB026_RS16900	COG0385	Bile acid
PRtIB026_RS16915	COG0393	Putative heavy-metal-binding
PRtIB026_RS16930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PRtIB026_RS16930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PRtIB026_RS16935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PRtIB026_RS16935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PRtIB026_RS16950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PRtIB026_RS16955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PRtIB026_RS16955	COG0515	serine threonine protein kinase
PRtIB026_RS16970	COG0500	methyltransferase
PRtIB026_RS16995	COG1917	Cupin 2, conserved barrel domain protein
PRtIB026_RS16995	COG4977	sequence-specific DNA binding
PRtIB026_RS17005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PRtIB026_RS17010	COG1215	transferase activity, transferring glycosyl groups
PRtIB026_RS17030	COG2205	protein histidine kinase activity
PRtIB026_RS17035	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS17040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS17050	COG0776	regulation of translation
PRtIB026_RS17060	COG0746	molybdenum cofactor guanylyltransferase activity
PRtIB026_RS17075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS17085	COG0667	Aldo Keto reductase
PRtIB026_RS17135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PRtIB026_RS17140	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PRtIB026_RS17160	COG3706	GGDEF domain
PRtIB026_RS17180	COG0579	oxidoreductase
PRtIB026_RS17185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PRtIB026_RS17190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PRtIB026_RS17195	COG1309	transcriptional regulator
PRtIB026_RS17200	COG3185	4-Hydroxyphenylpyruvate dioxygenase
PRtIB026_RS17200	COG1082	Xylose isomerase domain protein TIM barrel
PRtIB026_RS17205	COG0477	Major facilitator Superfamily
PRtIB026_RS17215	COG0583	DNA-binding transcription factor activity
PRtIB026_RS17225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PRtIB026_RS17260	COG0583	DNA-binding transcription factor activity
PRtIB026_RS17285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PRtIB026_RS17290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PRtIB026_RS17315	COG1064	alcohol dehydrogenase
PRtIB026_RS17320	COG2207	Transcriptional regulator
PRtIB026_RS17330	COG2249	NAD(P)H dehydrogenase (quinone) activity
PRtIB026_RS17335	COG1595	DNA-templated transcription, initiation
PRtIB026_RS17350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PRtIB026_RS17375	COG1175	transmembrane transport
PRtIB026_RS17390	COG0246	Mannitol dehydrogenase
PRtIB026_RS17395	COG1070	Carbohydrate kinase
PRtIB026_RS17415	COG1053	succinate dehydrogenase
PRtIB026_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS17430	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PRtIB026_RS17465	COG2814	Major facilitator Superfamily
PRtIB026_RS17495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PRtIB026_RS17545	COG0776	regulation of translation
PRtIB026_RS17550	COG0072	phenylalanine-tRNA ligase activity
PRtIB026_RS17555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PRtIB026_RS17560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PRtIB026_RS17565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PRtIB026_RS17570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PRtIB026_RS17575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PRtIB026_RS17585	COG1278	Cold shock
PRtIB026_RS17605	COG1869	D-ribose catabolic process
PRtIB026_RS17610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PRtIB026_RS17615	COG1609	Transcriptional regulator
PRtIB026_RS17620	COG1172	Belongs to the binding-protein-dependent transport system permease family
PRtIB026_RS17625	COG1129	ABC transporter
PRtIB026_RS17635	COG0252	asparaginase activity
PRtIB026_RS17650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PRtIB026_RS17675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS17690	COG1253	flavin adenine dinucleotide binding
PRtIB026_RS17700	COG0583	DNA-binding transcription factor activity
PRtIB026_RS17705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PRtIB026_RS17710	COG3132	Protein of unknown function, DUF480
PRtIB026_RS17735	COG3829	transcription factor binding
PRtIB026_RS17750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PRtIB026_RS17775	COG1132	(ABC) transporter
PRtIB026_RS17780	COG1132	(ABC) transporter
PRtIB026_RS17785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PRtIB026_RS17800	COG4771	TonB-dependent receptor
PRtIB026_RS17845	COG0640	Transcriptional regulator
PRtIB026_RS17855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PRtIB026_RS17895	COG1418	mRNA catabolic process
PRtIB026_RS17900	COG2813	Specifically methylates the guanine in position
PRtIB026_RS17935	COG3245	cytochrome
PRtIB026_RS18030	COG3179	chitinase
PRtIB026_RS18070	COG2271	Major facilitator Superfamily
PRtIB026_RS18075	COG0668	transmembrane transport
PRtIB026_RS18095	COG3387	PFAM Glycoside hydrolase 15-related
PRtIB026_RS18100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PRtIB026_RS18105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PRtIB026_RS18110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PRtIB026_RS18120	COG0297	glycogen (starch) synthase activity
PRtIB026_RS18130	COG1640	4-alpha-glucanotransferase
PRtIB026_RS18150	COG3568	Endonuclease Exonuclease Phosphatase
PRtIB026_RS18160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PRtIB026_RS18165	COG0366	Alpha amylase catalytic
PRtIB026_RS18185	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS18190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PRtIB026_RS18220	COG2866	Carboxypeptidase
PRtIB026_RS18265	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS18285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PRtIB026_RS18305	COG0517	IMP dehydrogenase activity
PRtIB026_RS18335	COG0720	synthase
PRtIB026_RS18370	COG0372	Belongs to the citrate synthase family
PRtIB026_RS18380	COG1802	Transcriptional regulator
PRtIB026_RS18385	COG0189	ligase activity
PRtIB026_RS18385	COG4067	protein conserved in archaea
PRtIB026_RS18415	COG0589	response to stress
PRtIB026_RS18420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PRtIB026_RS18445	COG1388	LysM domain
PRtIB026_RS18445	COG1376	ErfK ybiS ycfS ynhG family protein
PRtIB026_RS18460	COG4181	ATPase activity
PRtIB026_RS18465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PRtIB026_RS18470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PRtIB026_RS18480	COG2259	Doxx family
PRtIB026_RS18485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PRtIB026_RS18490	COG0084	hydrolase, TatD family'
PRtIB026_RS18525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PRtIB026_RS18535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PRtIB026_RS18540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PRtIB026_RS18545	COG0740	serine-type endopeptidase activity
PRtIB026_RS18550	COG0544	peptidyl-prolyl cis-trans isomerase activity
PRtIB026_RS18580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PRtIB026_RS18590	COG2423	ornithine cyclodeaminase activity
PRtIB026_RS18600	COG4215	(ABC) transporter
PRtIB026_RS18610	COG4598	ABC transporter
PRtIB026_RS18625	COG0840	transmembrane signaling receptor activity
PRtIB026_RS18680	COG0583	DNA-binding transcription factor activity
PRtIB026_RS18685	COG0840	transmembrane signaling receptor activity
PRtIB026_RS18695	COG0251	oxidation-reduction process
PRtIB026_RS18710	COG0730	response to heat
PRtIB026_RS18765	COG4178	(ABC) transporter
PRtIB026_RS18780	COG3383	formate dehydrogenase (NAD+) activity
PRtIB026_RS18795	COG0754	glutathionylspermidine amidase activity
PRtIB026_RS18805	COG3766	membrane
PRtIB026_RS18865	COG3712	iron ion homeostasis
PRtIB026_RS18870	COG1595	DNA-templated transcription, initiation
PRtIB026_RS18930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PRtIB026_RS18935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PRtIB026_RS18950	COG4566	intracellular signal transduction
PRtIB026_RS18960	COG2853	Lipoprotein
PRtIB026_RS18975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PRtIB026_RS18975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PRtIB026_RS19000	COG4591	ABC-type transport system involved in lipoprotein release permease component
PRtIB026_RS19005	COG1136	(ABC) transporter
PRtIB026_RS19010	COG4591	ABC-type transport system involved in lipoprotein release permease component
PRtIB026_RS19020	COG0584	glycerophosphoryl diester phosphodiesterase
PRtIB026_RS19025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PRtIB026_RS19030	COG1477	protein flavinylation
PRtIB026_RS19040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PRtIB026_RS19095	COG0183	Belongs to the thiolase family
PRtIB026_RS19100	COG1024	Enoyl-CoA hydratase
PRtIB026_RS19100	COG1250	3-hydroxyacyl-CoA dehydrogenase
PRtIB026_RS19110	COG0589	response to stress
PRtIB026_RS19115	COG0488	(ABC) transporter
PRtIB026_RS19120	COG0741	lytic transglycosylase activity
PRtIB026_RS19130	COG0784	Response regulator, receiver
PRtIB026_RS19130	COG0835	chemotaxis
PRtIB026_RS19145	COG2197	response regulator
PRtIB026_RS19150	COG1597	lipid kinase activity
PRtIB026_RS19160	COG0438	transferase activity, transferring glycosyl groups
PRtIB026_RS19170	COG0521	Mo-molybdopterin cofactor biosynthetic process
PRtIB026_RS19205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PRtIB026_RS19210	COG0425	Belongs to the sulfur carrier protein TusA family
PRtIB026_RS19230	COG0840	transmembrane signaling receptor activity
PRtIB026_RS19235	COG0564	pseudouridine synthase activity
PRtIB026_RS19275	COG2197	response regulator
PRtIB026_RS19280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS19280	COG2205	protein histidine kinase activity
PRtIB026_RS19285	COG3171	Protein conserved in bacteria
PRtIB026_RS19295	COG3415	Transposase
PRtIB026_RS19295	COG2801	Transposase and inactivated derivatives
PRtIB026_RS19310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PRtIB026_RS19310	COG0116	Belongs to the methyltransferase superfamily
PRtIB026_RS19315	COG3130	regulation of translation
PRtIB026_RS19320	COG0167	dihydroorotate dehydrogenase activity
PRtIB026_RS19325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PRtIB026_RS19325	COG1116	anion transmembrane transporter activity
PRtIB026_RS19330	COG3707	response regulator
PRtIB026_RS19335	COG2223	nitrite transmembrane transporter activity
PRtIB026_RS19355	COG0668	transmembrane transport
PRtIB026_RS19370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PRtIB026_RS19385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PRtIB026_RS19400	COG2186	Transcriptional regulator
PRtIB026_RS19405	COG0579	oxidoreductase
PRtIB026_RS19425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PRtIB026_RS19470	COG0714	Associated with various cellular activities
PRtIB026_RS19500	COG0420	3'-5' exonuclease activity
PRtIB026_RS19540	COG0308	aminopeptidase N
PRtIB026_RS19550	COG3139	Protein of unknown function (DUF1315)
PRtIB026_RS19560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PRtIB026_RS19565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PRtIB026_RS19580	COG3038	cytochrome b561
PRtIB026_RS19590	COG1902	pentaerythritol trinitrate reductase activity
PRtIB026_RS19590	COG0446	pyridine nucleotide-disulphide oxidoreductase
PRtIB026_RS19645	COG1286	toxin biosynthetic process
PRtIB026_RS19655	COG0285	dihydrofolate synthase activity
PRtIB026_RS19660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PRtIB026_RS19665	COG0135	phosphoribosylanthranilate isomerase activity
PRtIB026_RS19695	COG0473	3-isopropylmalate dehydrogenase activity
PRtIB026_RS19700	COG0066	3-isopropylmalate dehydratase activity
PRtIB026_RS19705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PRtIB026_RS19725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PRtIB026_RS19735	COG0596	Alpha beta hydrolase
PRtIB026_RS19770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PRtIB026_RS19785	COG0556	nucleotide-excision repair
PRtIB026_RS19820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PRtIB026_RS19830	COG1104	cysteine desulfurase activity
PRtIB026_RS19835	COG0084	hydrolase, TatD family'
PRtIB026_RS19860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PRtIB026_RS19870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PRtIB026_RS19875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PRtIB026_RS19890	COG0416	fatty acid biosynthetic process
PRtIB026_RS19895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PRtIB026_RS19905	COG0424	maF-like protein
PRtIB026_RS19910	COG0616	signal peptide processing
PRtIB026_RS19910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PRtIB026_RS19930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PRtIB026_RS19935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PRtIB026_RS19940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PRtIB026_RS19945	COG2835	tetraacyldisaccharide 4'-kinase activity
PRtIB026_RS19950	COG1663	tetraacyldisaccharide 4'-kinase activity
PRtIB026_RS19955	COG0848	biopolymer transport protein
PRtIB026_RS19960	COG0811	peptide transport
PRtIB026_RS19965	COG2333	competence protein COMEC
PRtIB026_RS19965	COG0658	competence protein
PRtIB026_RS19975	COG0842	Transport permease protein
PRtIB026_RS19980	COG1131	(ABC) transporter
PRtIB026_RS19985	COG0625	glutathione transferase activity
PRtIB026_RS20045	COG1956	GAF domain-containing protein
PRtIB026_RS20055	COG3850	Histidine kinase
PRtIB026_RS20055	COG2205	protein histidine kinase activity
PRtIB026_RS20055	COG3437	response regulator, receiver
PRtIB026_RS20055	COG4999	Histidine kinase
PRtIB026_RS20060	COG0386	Belongs to the glutathione peroxidase family
PRtIB026_RS20065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PRtIB026_RS20075	COG0501	Belongs to the peptidase M48B family
PRtIB026_RS20085	COG0500	methyltransferase
PRtIB026_RS20090	COG3384	dioxygenase
PRtIB026_RS20105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PRtIB026_RS20110	COG3214	Protein conserved in bacteria
PRtIB026_RS20120	COG0583	DNA-binding transcription factor activity
PRtIB026_RS20130	COG0583	DNA-binding transcription factor activity
PRtIB026_RS20135	COG1846	Transcriptional regulator
PRtIB026_RS20140	COG1764	response to oxidative stress
PRtIB026_RS20145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PRtIB026_RS20165	COG0583	DNA-binding transcription factor activity
PRtIB026_RS20170	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS20175	COG0583	DNA-binding transcription factor activity
PRtIB026_RS20205	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PRtIB026_RS20230	COG0204	Acyl-transferase
PRtIB026_RS20235	COG0598	Magnesium transport protein CorA
PRtIB026_RS20240	COG0519	Catalyzes the synthesis of GMP from XMP
PRtIB026_RS20260	COG1368	sulfuric ester hydrolase activity
PRtIB026_RS20290	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PRtIB026_RS20295	COG2814	Major facilitator Superfamily
PRtIB026_RS20300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PRtIB026_RS20330	COG2840	Smr protein MutS2
PRtIB026_RS20335	COG0302	gtp cyclohydrolase
PRtIB026_RS20345	COG0625	glutathione transferase activity
PRtIB026_RS20350	COG3135	benzoate transporter
PRtIB026_RS20355	COG0840	transmembrane signaling receptor activity
PRtIB026_RS20375	COG2130	NADP-dependent
PRtIB026_RS20380	COG0284	orotidine-5'-phosphate decarboxylase activity
PRtIB026_RS20390	COG1555	photosystem II stabilization
PRtIB026_RS20415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PRtIB026_RS20435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PRtIB026_RS20445	COG0463	Glycosyl transferase, family 2
PRtIB026_RS20450	COG2244	polysaccharide biosynthetic process
PRtIB026_RS20485	COG0776	regulation of translation
PRtIB026_RS20495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PRtIB026_RS20500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PRtIB026_RS20510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PRtIB026_RS20520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PRtIB026_RS20525	COG0402	S-adenosylhomocysteine deaminase activity
PRtIB026_RS20530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PRtIB026_RS20535	COG0546	phosphoglycolate phosphatase activity
PRtIB026_RS20540	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS20550	COG5002	protein histidine kinase activity
PRtIB026_RS20550	COG5001	Diguanylate cyclase
PRtIB026_RS20565	COG1054	Belongs to the UPF0176 family
PRtIB026_RS20570	COG0271	Belongs to the BolA IbaG family
PRtIB026_RS20585	COG0697	spore germination
PRtIB026_RS20590	COG2326	polyphosphate kinase activity
PRtIB026_RS20595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS20595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PRtIB026_RS20600	COG0367	asparagine synthase
PRtIB026_RS20605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PRtIB026_RS20605	COG0189	ligase activity
PRtIB026_RS20610	COG1363	Peptidase, m42
PRtIB026_RS20615	COG3089	Belongs to the UPF0270 family
PRtIB026_RS20620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PRtIB026_RS20635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PRtIB026_RS20640	COG3162	membrane
PRtIB026_RS20645	COG2113	Glycine betaine
PRtIB026_RS20675	COG1560	Kdo2-lipid A biosynthetic process
PRtIB026_RS20680	COG0850	regulation of cytokinetic process
PRtIB026_RS20685	COG2894	cell division
PRtIB026_RS20690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PRtIB026_RS20695	COG0564	pseudouridine synthase activity
PRtIB026_RS20700	COG1362	aminopeptidase activity
PRtIB026_RS20710	COG0668	transmembrane transport
PRtIB026_RS20725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PRtIB026_RS20730	COG0395	ABC-type sugar transport system, permease component
PRtIB026_RS20750	COG2076	Multidrug Resistance protein
PRtIB026_RS20755	COG0477	Major facilitator Superfamily
PRtIB026_RS20775	COG2814	Major facilitator Superfamily
PRtIB026_RS20780	COG2205	protein histidine kinase activity
PRtIB026_RS20825	COG1846	Transcriptional regulator
PRtIB026_RS20835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PRtIB026_RS20840	COG0406	alpha-ribazole phosphatase activity
PRtIB026_RS20845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PRtIB026_RS20855	COG1492	cobalamin metabolic process
PRtIB026_RS20865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PRtIB026_RS20870	COG0778	Nitroreductase
PRtIB026_RS20875	COG1797	cobyrinic acid a,c-diamide synthase activity
PRtIB026_RS20900	COG0791	NLP P60 protein
PRtIB026_RS20910	COG0628	permease
PRtIB026_RS20920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PRtIB026_RS20925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PRtIB026_RS20940	COG3122	Protein conserved in bacteria
PRtIB026_RS20945	COG3956	TIGRFAM MazG family protein
PRtIB026_RS20950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PRtIB026_RS20955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PRtIB026_RS20975	COG0784	Response regulator, receiver
PRtIB026_RS20975	COG2205	protein histidine kinase activity
PRtIB026_RS20975	COG5002	protein histidine kinase activity
PRtIB026_RS20980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRtIB026_RS21000	COG1393	Belongs to the ArsC family
PRtIB026_RS21020	COG0037	tRNA processing
PRtIB026_RS21030	COG3091	SprT-like family
PRtIB026_RS21035	COG1301	dicarboxylic acid transport
PRtIB026_RS21065	COG2205	protein histidine kinase activity
PRtIB026_RS21070	COG0745	RESPONSE REGULATOR receiver
PRtIB026_RS21075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PRtIB026_RS21075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PRtIB026_RS21080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PRtIB026_RS21115	COG0604	alcohol dehydrogenase
PRtIB026_RS21115	COG3321	synthase
PRtIB026_RS21135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PRtIB026_RS21140	COG0583	DNA-binding transcription factor activity
PRtIB026_RS21145	COG1017	nitric oxide dioxygenase activity
PRtIB026_RS21145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PRtIB026_RS21150	COG0625	glutathione transferase activity
PRtIB026_RS21155	COG3318	Belongs to the UPF0149 family
PRtIB026_RS21155	COG3012	SEC-C Motif Domain Protein
PRtIB026_RS21160	COG0252	asparaginase activity
PRtIB026_RS21170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PRtIB026_RS21220	COG3706	GGDEF domain
PRtIB026_RS21225	COG5001	Diguanylate cyclase
PRtIB026_RS21235	COG0583	DNA-binding transcription factor activity
PRtIB026_RS21250	COG4221	oxidoreductase activity
PRtIB026_RS21280	COG2084	Dehydrogenase
PRtIB026_RS21340	COG0259	pyridoxamine-phosphate oxidase activity
PRtIB026_RS21345	COG2885	chlorophyll binding
PRtIB026_RS21360	COG1199	ATP-dependent helicase activity
PRtIB026_RS21400	COG3012	SEC-C Motif Domain Protein
PRtIB026_RS21410	COG0653	protein targeting
PRtIB026_RS21415	COG2366	antibiotic biosynthetic process
PRtIB026_RS21420	COG1598	PFAM Uncharacterised protein family UPF0150
PRtIB026_RS21435	COG0717	Belongs to the dCTP deaminase family
PRtIB026_RS21440	COG1278	Cold shock
PRtIB026_RS21445	COG0489	protein tyrosine kinase activity
PRtIB026_RS21450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PRtIB026_RS21450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PRtIB026_RS21455	COG4657	Part of a membrane complex involved in electron transport
PRtIB026_RS21475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PRtIB026_RS21495	COG0137	argininosuccinate synthase activity
PRtIB026_RS21505	COG0418	dihydroorotase activity
PRtIB026_RS21510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PRtIB026_RS21520	COG0450	alkyl hydroperoxide reductase
PRtIB026_RS21535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PRtIB026_RS21540	COG0243	molybdopterin cofactor binding
PRtIB026_RS21545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PRtIB026_RS21560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PRtIB026_RS21570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PRtIB026_RS21590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS21595	COG0765	amino acid transport
PRtIB026_RS21600	COG0765	amino acid transport
PRtIB026_RS21605	COG1126	abc transporter atp-binding protein
PRtIB026_RS21625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PRtIB026_RS21630	COG0583	DNA-binding transcription factor activity
PRtIB026_RS21645	COG0254	rRNA binding
PRtIB026_RS21650	COG0069	glutamate synthase activity
PRtIB026_RS21655	COG1113	amino acid transport
PRtIB026_RS21665	COG1695	Transcriptional regulator
PRtIB026_RS21670	COG2375	cellular response to nickel ion
PRtIB026_RS21680	COG4628	conserved protein (DUF2132)
PRtIB026_RS21685	COG4206	TonB-dependent receptor
PRtIB026_RS21700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PRtIB026_RS21710	COG2226	methyltransferase
PRtIB026_RS21715	COG0500	methyltransferase
PRtIB026_RS21735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PRtIB026_RS21740	COG1381	Involved in DNA repair and RecF pathway recombination
PRtIB026_RS21745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PRtIB026_RS21750	COG0571	ribonuclease III activity
PRtIB026_RS21755	COG0681	Belongs to the peptidase S26 family
PRtIB026_RS21765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PRtIB026_RS21815	COG3339	Conserved Protein
PRtIB026_RS21820	COG0545	Peptidyl-prolyl cis-trans isomerase
PRtIB026_RS21825	COG0024	Methionine aminopeptidase
PRtIB026_RS21835	COG0243	molybdopterin cofactor binding
PRtIB026_RS21840	COG2146	nitrite reductase [NAD(P)H] activity
PRtIB026_RS21840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PRtIB026_RS21855	COG0583	DNA-binding transcription factor activity
PRtIB026_RS21865	COG2214	Heat shock protein DnaJ domain protein
PRtIB026_RS21870	COG0443	Heat shock 70 kDa protein
PRtIB026_RS21895	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PRtIB026_RS21900	COG0354	folic acid binding
PRtIB026_RS21945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PRtIB026_RS21995	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
PRtIB026_RS22010	COG4774	siderophore transport
PRtIB026_RS22020	COG1595	DNA-templated transcription, initiation
PRtIB026_RS22025	COG0584	glycerophosphoryl diester phosphodiesterase
PRtIB026_RS22070	COG4191	Histidine kinase
PRtIB026_RS22080	COG0477	Major facilitator Superfamily
PRtIB026_RS22115	COG2207	Transcriptional regulator
PRtIB026_RS22125	COG0583	DNA-binding transcription factor activity
PRtIB026_RS22130	COG2910	NAD(P)H-binding
PRtIB026_RS22150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PRtIB026_RS22155	COG0477	Major facilitator Superfamily
PRtIB026_RS22160	COG1309	transcriptional regulator
PRtIB026_RS22165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS22175	COG1538	Outer membrane efflux protein
PRtIB026_RS22200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PRtIB026_RS22210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PRtIB026_RS22215	COG0477	Major facilitator Superfamily
PRtIB026_RS22220	COG0183	Belongs to the thiolase family
PRtIB026_RS22225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PRtIB026_RS22230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PRtIB026_RS22235	COG2814	Major facilitator Superfamily
PRtIB026_RS22240	COG1414	Transcriptional regulator
PRtIB026_RS22250	COG0306	phosphate transporter
PRtIB026_RS22255	COG0433	COG0433 Predicted ATPase
PRtIB026_RS22260	COG0840	transmembrane signaling receptor activity
PRtIB026_RS22290	COG2925	Exonuclease
PRtIB026_RS22305	COG0469	pyruvate kinase activity
PRtIB026_RS22325	COG0693	protein deglycase activity
PRtIB026_RS22360	COG0204	Acyl-transferase
PRtIB026_RS22365	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
PRtIB026_RS22375	COG1902	pentaerythritol trinitrate reductase activity
PRtIB026_RS22385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PRtIB026_RS22390	COG0583	DNA-binding transcription factor activity
PRtIB026_RS22400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PRtIB026_RS22430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS22435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PRtIB026_RS22445	COG2801	Transposase and inactivated derivatives
PRtIB026_RS22445	COG3415	Transposase
PRtIB026_RS22455	COG3642	lipopolysaccharide core region biosynthetic process
PRtIB026_RS22465	COG0642	Histidine kinase
PRtIB026_RS22480	COG0459	protein refolding
PRtIB026_RS22485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PRtIB026_RS22520	COG0668	transmembrane transport
PRtIB026_RS22525	COG1666	GTP binding
PRtIB026_RS22535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS22535	COG4191	Histidine kinase
PRtIB026_RS22540	COG2096	Adenosyltransferase
PRtIB026_RS22545	COG0352	thiamine-phosphate diphosphorylase activity
PRtIB026_RS22555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PRtIB026_RS22560	COG0653	protein targeting
PRtIB026_RS22570	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PRtIB026_RS22575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PRtIB026_RS22590	COG1181	Belongs to the D-alanine--D-alanine ligase family
PRtIB026_RS22595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PRtIB026_RS22600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PRtIB026_RS22605	COG0772	Belongs to the SEDS family
PRtIB026_RS22610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PRtIB026_RS22615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PRtIB026_RS22620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PRtIB026_RS22625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PRtIB026_RS22640	COG0275	rRNA processing
PRtIB026_RS22645	COG2001	Belongs to the MraZ family
PRtIB026_RS22660	COG3107	peptidoglycan biosynthetic process
PRtIB026_RS22665	COG0792	nuclease activity
PRtIB026_RS22670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PRtIB026_RS22675	COG2823	Periplasmic or secreted lipoprotein
PRtIB026_RS22695	COG2969	positive regulation of protein catabolic process
PRtIB026_RS22700	COG0625	glutathione transferase activity
PRtIB026_RS22705	COG2857	Cytochrome c1
PRtIB026_RS22710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PRtIB026_RS22715	COG0723	plastoquinol--plastocyanin reductase activity
PRtIB026_RS22720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PRtIB026_RS22725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PRtIB026_RS22730	COG0667	Aldo Keto reductase
PRtIB026_RS22740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PRtIB026_RS22745	COG0180	Tryptophanyl-tRNA synthetase
PRtIB026_RS22760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PRtIB026_RS22770	COG1522	sequence-specific DNA binding
PRtIB026_RS22780	COG0175	sulfate reduction
PRtIB026_RS22790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PRtIB026_RS22800	COG0765	amino acid transport
PRtIB026_RS22805	COG4597	amino acid ABC transporter
PRtIB026_RS22810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS22815	COG0400	carboxylic ester hydrolase activity
PRtIB026_RS22820	COG0513	Belongs to the DEAD box helicase family
PRtIB026_RS22830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PRtIB026_RS22835	COG0315	cyclic pyranopterin monophosphate synthase activity
PRtIB026_RS22840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PRtIB026_RS22845	COG3639	organic phosphonate transmembrane transporter activity
PRtIB026_RS22850	COG3639	organic phosphonate transmembrane transporter activity
PRtIB026_RS22865	COG0709	Synthesizes selenophosphate from selenide and ATP
PRtIB026_RS22870	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PRtIB026_RS22930	COG0727	PFAM Uncharacterised protein family (UPF0153)
PRtIB026_RS22935	COG0436	Aminotransferase
PRtIB026_RS22945	COG0109	protoheme IX farnesyltransferase activity
PRtIB026_RS22950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PRtIB026_RS22955	COG1845	cytochrome c oxidase, subunit III
PRtIB026_RS22960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PRtIB026_RS22970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PRtIB026_RS22975	COG1017	nitric oxide dioxygenase activity
PRtIB026_RS22975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PRtIB026_RS22980	COG3604	Transcriptional regulator
PRtIB026_RS22985	COG0784	Response regulator, receiver
PRtIB026_RS22985	COG0835	chemotaxis
PRtIB026_RS23010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PRtIB026_RS23025	COG5002	protein histidine kinase activity
PRtIB026_RS23045	COG3706	GGDEF domain
PRtIB026_RS23045	COG2203	Gaf domain
PRtIB026_RS23045	COG5001	Diguanylate cyclase
PRtIB026_RS23045	COG4251	negative regulation of phosphorylation
PRtIB026_RS23055	COG3530	Putative quorum-sensing-regulated virulence factor
PRtIB026_RS23060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PRtIB026_RS23060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PRtIB026_RS23060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PRtIB026_RS23065	COG1105	Belongs to the carbohydrate kinase PfkB family
PRtIB026_RS23080	COG0084	hydrolase, TatD family'
PRtIB026_RS23090	COG3725	Membrane protein required for beta-lactamase induction
PRtIB026_RS23095	COG3023	N-Acetylmuramoyl-L-alanine amidase
PRtIB026_RS23110	COG0492	ferredoxin-NADP+ reductase activity
PRtIB026_RS23115	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PRtIB026_RS23190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PRtIB026_RS23195	COG2813	Specifically methylates the guanine in position
PRtIB026_RS23200	COG2119	membrane
PRtIB026_RS23210	COG0840	transmembrane signaling receptor activity
PRtIB026_RS23215	COG2135	peptidase activity
PRtIB026_RS23255	COG0579	oxidoreductase
PRtIB026_RS23275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PRtIB026_RS23280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PRtIB026_RS23290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PRtIB026_RS23295	COG1090	epimerase
PRtIB026_RS23305	COG3272	Protein of unknown function (DUF1722)
PRtIB026_RS23325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PRtIB026_RS23330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PRtIB026_RS23340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PRtIB026_RS23345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PRtIB026_RS23350	COG2801	Transposase and inactivated derivatives
PRtIB026_RS23350	COG3415	Transposase
PRtIB026_RS23360	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PRtIB026_RS23365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PRtIB026_RS23375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PRtIB026_RS23380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PRtIB026_RS23385	COG0193	aminoacyl-tRNA hydrolase activity
PRtIB026_RS23395	COG2814	Major facilitator Superfamily
PRtIB026_RS23405	COG1566	PFAM secretion protein HlyD family protein
PRtIB026_RS23420	COG1335	isochorismatase
PRtIB026_RS23425	COG1335	isochorismatase
PRtIB026_RS23430	COG3177	Filamentation induced by cAMP protein fic
PRtIB026_RS23465	COG1511	domain protein
PRtIB026_RS23465	COG3264	Mechanosensitive ion channel
PRtIB026_RS23470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PRtIB026_RS23470	COG2169	Transcriptional regulator
PRtIB026_RS23480	COG1595	DNA-templated transcription, initiation
PRtIB026_RS23485	COG3712	iron ion homeostasis
PRtIB026_RS23495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PRtIB026_RS23515	COG2026	Addiction module toxin, RelE StbE family
PRtIB026_RS23520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PRtIB026_RS23520	COG2205	protein histidine kinase activity
PRtIB026_RS23520	COG0784	Response regulator, receiver
PRtIB026_RS23520	COG2198	Histidine kinase
PRtIB026_RS23585	COG1764	response to oxidative stress
PRtIB026_RS23640	COG0464	growth
PRtIB026_RS23665	COG0237	dephospho-CoA kinase activity
PRtIB026_RS23695	COG1252	NADH dehydrogenase
PRtIB026_RS23700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PRtIB026_RS23720	COG0542	response to heat
PRtIB026_RS23745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PRtIB026_RS23775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PRtIB026_RS23780	COG1047	Peptidyl-prolyl cis-trans
PRtIB026_RS23785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PRtIB026_RS23790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PRtIB026_RS23795	COG0196	riboflavin kinase activity
PRtIB026_RS23805	COG0268	Binds directly to 16S ribosomal RNA
PRtIB026_RS23820	COG2223	nitrite transmembrane transporter activity
PRtIB026_RS23870	COG3008	intermembrane lipid transfer
PRtIB026_RS23875	COG2995	paraquat-inducible protein a
PRtIB026_RS23880	COG2995	paraquat-inducible protein a
PRtIB026_RS23915	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PRtIB026_RS23920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PRtIB026_RS23925	COG1183	phosphatidylcholine synthase activity
PRtIB026_RS23930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PRtIB026_RS23940	COG0028	Belongs to the TPP enzyme family
PRtIB026_RS23945	COG3098	single-species biofilm formation
PRtIB026_RS23955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PRtIB026_RS23980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PRtIB026_RS23990	COG4558	Periplasmic binding protein
PRtIB026_RS24000	COG1489	DNA binding
PRtIB026_RS24005	COG0436	Aminotransferase
PRtIB026_RS24015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PRtIB026_RS24025	COG4191	Histidine kinase
PRtIB026_RS24030	COG2204	response regulator
PRtIB026_RS24035	COG0617	tRNA 3'-terminal CCA addition
PRtIB026_RS24045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PRtIB026_RS24050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PRtIB026_RS24055	COG0166	Belongs to the GPI family
PRtIB026_RS24060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PRtIB026_RS24065	COG0640	Transcriptional regulator
PRtIB026_RS24075	COG2329	Antibiotic biosynthesis monooxygenase
PRtIB026_RS24100	COG2823	Periplasmic or secreted lipoprotein
PRtIB026_RS24105	COG1185	polyribonucleotide nucleotidyltransferase activity
PRtIB026_RS24110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PRtIB026_RS24115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PRtIB026_RS24120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PRtIB026_RS24125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PRtIB026_RS24130	COG0195	Participates in both transcription termination and antitermination
PRtIB026_RS24135	COG0779	Required for maturation of 30S ribosomal subunits
PRtIB026_RS24150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PRtIB026_RS24155	COG0149	triose-phosphate isomerase activity
PRtIB026_RS24160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PRtIB026_RS24165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PRtIB026_RS24175	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PRtIB026_RS24190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PRtIB026_RS24195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PRtIB026_RS24200	COG0505	Belongs to the CarA family
PRtIB026_RS24205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PRtIB026_RS24210	COG0484	heat shock protein binding
PRtIB026_RS24215	COG0443	Heat shock 70 kDa protein
PRtIB026_RS24220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PRtIB026_RS24225	COG0497	DNA recombination
PRtIB026_RS24235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PRtIB026_RS24245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PRtIB026_RS24255	COG1620	l-lactate permease
PRtIB026_RS24260	COG1304	FMN binding
PRtIB026_RS24270	COG2264	protein methyltransferase activity
PRtIB026_RS24280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PRtIB026_RS24290	COG0138	bifunctional purine biosynthesis protein purh
PRtIB026_RS24295	COG0151	Belongs to the GarS family
PRtIB026_RS24305	COG2095	MarC family integral membrane protein
PRtIB026_RS24325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PRtIB026_RS24335	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PRtIB026_RS24360	COG0330	HflC and HflK could
PRtIB026_RS24390	COG1113	amino acid transport
PRtIB026_RS24435	COG0789	Transcriptional regulator
PRtIB026_RS24440	COG0484	heat shock protein binding
PRtIB026_RS24445	COG0443	Heat shock 70 kDa protein
PRtIB026_RS24470	COG0697	spore germination
PRtIB026_RS24490	COG2982	Protein involved in outer membrane biogenesis
PRtIB026_RS24520	COG1643	Atp-dependent helicase
PRtIB026_RS24540	COG1522	sequence-specific DNA binding
PRtIB026_RS24555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PRtIB026_RS24560	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS24565	COG5002	protein histidine kinase activity
PRtIB026_RS24565	COG2205	protein histidine kinase activity
PRtIB026_RS24565	COG0784	Response regulator, receiver
PRtIB026_RS24570	COG0351	phosphomethylpyrimidine kinase
PRtIB026_RS24575	COG0352	thiamine-phosphate diphosphorylase activity
PRtIB026_RS24580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PRtIB026_RS24590	COG1702	phosphate starvation-inducible protein PhoH
PRtIB026_RS24595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PRtIB026_RS24600	COG4535	Mg2 and Co2 transporter CorC
PRtIB026_RS24605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PRtIB026_RS24610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PRtIB026_RS24620	COG0495	leucyl-tRNA aminoacylation
PRtIB026_RS24640	COG2951	lytic endotransglycosylase activity
PRtIB026_RS24650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PRtIB026_RS24655	COG0321	lipoyl(octanoyl) transferase activity
PRtIB026_RS24660	COG2921	Belongs to the UPF0250 family
PRtIB026_RS24665	COG1686	Belongs to the peptidase S11 family
PRtIB026_RS24675	COG2951	lytic endotransglycosylase activity
PRtIB026_RS24680	COG0772	Belongs to the SEDS family
PRtIB026_RS24685	COG0768	penicillin binding
PRtIB026_RS24690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PRtIB026_RS24700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PRtIB026_RS24705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PRtIB026_RS24710	COG2094	Belongs to the DNA glycosylase MPG family
PRtIB026_RS24715	COG0586	Pfam SNARE associated Golgi protein
PRtIB026_RS24725	COG1346	cytolysis
PRtIB026_RS24745	COG0702	epimerase
PRtIB026_RS24760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PRtIB026_RS24775	COG0531	amino acid
PRtIB026_RS24780	COG4303	Ethanolamine ammonia lyase large subunit
PRtIB026_RS24785	COG4302	ethanolamine ammonia-lyase activity
PRtIB026_RS24790	COG0456	acetyltransferase
PRtIB026_RS24795	COG0586	Pfam SNARE associated Golgi protein
PRtIB026_RS24800	COG3228	Belongs to the MtfA family
PRtIB026_RS24805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PRtIB026_RS24815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PRtIB026_RS24820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PRtIB026_RS24825	COG0330	HflC and HflK could
PRtIB026_RS24830	COG0330	HflC and HflK could
PRtIB026_RS24835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PRtIB026_RS24840	COG1923	regulation of RNA biosynthetic process
PRtIB026_RS24845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PRtIB026_RS24850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PRtIB026_RS24855	COG0860	N-Acetylmuramoyl-L-alanine amidase
PRtIB026_RS24860	COG0802	atpase or kinase
PRtIB026_RS24865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PRtIB026_RS24865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PRtIB026_RS24880	COG2860	membrane
PRtIB026_RS24885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PRtIB026_RS24890	COG1162	GTPase activity
PRtIB026_RS24920	COG0688	phosphatidylethanolamine metabolic process
PRtIB026_RS24925	COG3830	Belongs to the UPF0237 family
PRtIB026_RS24925	COG0560	Phosphoserine phosphatase
PRtIB026_RS24945	COG3577	Aspartyl protease
PRtIB026_RS24960	COG3150	esterase
PRtIB026_RS24965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PRtIB026_RS24975	COG0494	nUDIX hydrolase
PRtIB026_RS24990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PRtIB026_RS24995	COG1538	Outer membrane efflux protein
PRtIB026_RS25000	COG1519	Transferase
PRtIB026_RS25005	COG0583	DNA-binding transcription factor activity
PRtIB026_RS25020	COG0656	L-ascorbic acid biosynthetic process
PRtIB026_RS25035	COG1132	(ABC) transporter
PRtIB026_RS25070	COG0438	transferase activity, transferring glycosyl groups
PRtIB026_RS25075	COG2192	nodulation
PRtIB026_RS25080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PRtIB026_RS25085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PRtIB026_RS25090	COG0506	proline dehydrogenase activity
PRtIB026_RS25090	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PRtIB026_RS25090	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PRtIB026_RS25110	COG1960	acyl-CoA dehydrogenase activity
PRtIB026_RS25120	COG0312	modulator of DNA gyrase
PRtIB026_RS25125	COG0477	Major facilitator Superfamily
PRtIB026_RS25130	COG0513	Belongs to the DEAD box helicase family
PRtIB026_RS25135	COG2081	HI0933 family
PRtIB026_RS25140	COG1289	transmembrane transporter activity
PRtIB026_RS25170	COG1451	nucleotide metabolic process
PRtIB026_RS25175	COG5001	Diguanylate cyclase
PRtIB026_RS25175	COG3300	MHYT domain
PRtIB026_RS25195	COG0126	phosphoglycerate kinase activity
PRtIB026_RS25200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PRtIB026_RS25210	COG0640	Transcriptional regulator
PRtIB026_RS25215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PRtIB026_RS25220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PRtIB026_RS25270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PRtIB026_RS25275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PRtIB026_RS25285	COG0513	Belongs to the DEAD box helicase family
PRtIB026_RS25290	COG2353	YceI-like domain
PRtIB026_RS25295	COG3038	cytochrome b561
PRtIB026_RS25315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PRtIB026_RS25320	COG1272	protein, Hemolysin III
PRtIB026_RS25330	COG0643	Histidine kinase
PRtIB026_RS25330	COG0784	Response regulator, receiver
PRtIB026_RS25330	COG2198	Histidine kinase
PRtIB026_RS25330	COG0643	Histidine kinase
PRtIB026_RS25330	COG2198	Histidine kinase
PRtIB026_RS25330	COG0784	Response regulator, receiver
PRtIB026_RS25355	COG0189	ligase activity
PRtIB026_RS25365	COG1678	Uncharacterized ACR, COG1678
PRtIB026_RS25370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PRtIB026_RS25375	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PRtIB026_RS25380	COG0540	Belongs to the ATCase OTCase family
PRtIB026_RS25385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PRtIB026_RS25390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PRtIB026_RS25395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PRtIB026_RS25440	COG2226	methyltransferase
PRtIB026_RS25450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PRtIB026_RS25455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PRtIB026_RS25460	COG0140	phosphoribosyl-ATP diphosphatase activity
PRtIB026_RS25465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PRtIB026_RS25470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PRtIB026_RS25485	COG0840	transmembrane signaling receptor activity
PRtIB026_RS25490	COG0840	transmembrane signaling receptor activity
PRtIB026_RS25500	COG1126	abc transporter atp-binding protein
PRtIB026_RS25515	COG2943	transferase activity, transferring hexosyl groups
PRtIB026_RS25520	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PRtIB026_RS25525	COG1490	D-aminoacyl-tRNA deacylase activity
PRtIB026_RS25540	COG1228	amidohydrolase
PRtIB026_RS25555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PRtIB026_RS25565	COG2188	Transcriptional regulator
PRtIB026_RS25570	COG0402	S-adenosylhomocysteine deaminase activity
PRtIB026_RS25595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PRtIB026_RS25600	COG0058	SHG alpha-glucan phosphorylase activity
PRtIB026_RS25610	COG1217	gtp-binding protein TYPA
PRtIB026_RS25615	COG0301	tRNA thio-modification
PRtIB026_RS25615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PRtIB026_RS25625	COG3852	Histidine kinase
PRtIB026_RS25650	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PRtIB026_RS25660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PRtIB026_RS25665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PRtIB026_RS25670	COG4942	peptidase
PRtIB026_RS25675	COG0793	Belongs to the peptidase S41A family
PRtIB026_RS25680	COG2861	carbohydrate metabolic process
PRtIB026_RS25695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PRtIB026_RS25700	COG1309	transcriptional regulator
PRtIB026_RS25705	COG1012	belongs to the aldehyde dehydrogenase family
PRtIB026_RS25710	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PRtIB026_RS25715	COG3263	regulation of cellular component size
PRtIB026_RS25720	COG1196	nuclear chromosome segregation
PRtIB026_RS25720	COG3264	Mechanosensitive ion channel
PRtIB026_RS25725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PRtIB026_RS25730	COG3118	belongs to the thioredoxin family
PRtIB026_RS25745	COG1192	Involved in chromosome partitioning
PRtIB026_RS25760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PRtIB026_RS25765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PRtIB026_RS25775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PRtIB026_RS25790	COG2986	histidine ammonia-lyase
PRtIB026_RS25820	COG2226	methyltransferase
PRtIB026_RS25830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PRtIB026_RS25840	COG1028	Short-chain dehydrogenase reductase Sdr
PRtIB026_RS25845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PRtIB026_RS25855	COG0583	DNA-binding transcription factor activity
PRtIB026_RS25860	COG2814	Major facilitator Superfamily
PRtIB026_RS25870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PRtIB026_RS25875	COG0493	'glutamate synthase
PRtIB026_RS25880	COG0070	glutamate synthase
PRtIB026_RS25880	COG0069	glutamate synthase activity
PRtIB026_RS25880	COG0067	glutamate synthase
PRtIB026_RS25890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PRtIB026_RS25895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PRtIB026_RS25925	COG0281	malic enzyme
PRtIB026_RS25935	COG0254	rRNA binding
PRtIB026_RS25940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PRtIB026_RS25945	COG0018	arginyl-trna synthetase
PRtIB026_RS25960	COG0791	NLP P60 protein
PRtIB026_RS25985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PRtIB026_RS25990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PRtIB026_RS25990	COG2813	Specifically methylates the guanine in position
PRtIB026_RS26000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PRtIB026_RS26005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PRtIB026_RS26015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PRtIB026_RS26020	COG2022	thiamine diphosphate biosynthetic process
PRtIB026_RS26030	COG2363	Small membrane protein
PRtIB026_RS26035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PRtIB026_RS26045	COG2177	Part of the ABC transporter FtsEX involved in
PRtIB026_RS26050	COG2884	Cell division ATP-binding protein ftsE
PRtIB026_RS26055	COG0552	protein localization to endoplasmic reticulum
PRtIB026_RS26060	COG0612	Peptidase, M16
PRtIB026_RS26065	COG0612	Peptidase, M16
PRtIB026_RS26070	COG0742	ribosomal rna small subunit methyltransferase
PRtIB026_RS26085	COG1309	transcriptional regulator
PRtIB026_RS26100	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PRtIB026_RS26105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PRtIB026_RS26110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PRtIB026_RS26120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PRtIB026_RS26125	COG1639	'signal transduction protein
PRtIB026_RS26130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PRtIB026_RS26140	COG0129	dihydroxy-acid dehydratase activity
PRtIB026_RS26145	COG1840	ABC-type Fe3 transport system, periplasmic component
PRtIB026_RS26155	COG3842	ATPase activity
PRtIB026_RS26160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PRtIB026_RS26165	COG0277	FAD linked oxidase domain protein
PRtIB026_RS26170	COG0179	Fumarylacetoacetate (FAA) hydrolase
PRtIB026_RS26175	COG3204	pilus organization
PRtIB026_RS26180	COG3204	pilus organization
PRtIB026_RS26185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PRtIB026_RS26190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PRtIB026_RS26205	COG0494	nUDIX hydrolase
PRtIB026_RS26255	COG2076	Multidrug Resistance protein
PRtIB026_RS26265	COG3655	Transcriptional regulator
PRtIB026_RS26285	COG0582	viral genome integration into host DNA
PRtIB026_RS26345	COG1823	symporter activity
PRtIB026_RS26355	COG3712	iron ion homeostasis
PRtIB026_RS26375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PRtIB026_RS26410	COG1136	(ABC) transporter
PRtIB026_RS26410	COG0577	efflux transmembrane transporter activity
PRtIB026_RS26435	COG1360	Flagellar Motor Protein
PRtIB026_RS26540	COG0069	glutamate synthase activity
PRtIB026_RS26555	COG2957	Belongs to the agmatine deiminase family
PRtIB026_RS26560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PRtIB026_RS26570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PRtIB026_RS26605	COG0494	nUDIX hydrolase
PRtIB026_RS26610	COG1011	Hydrolase
PRtIB026_RS26615	COG1652	LysM domain
PRtIB026_RS26620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PRtIB026_RS26625	COG0243	molybdopterin cofactor binding