locus-tag	class	description
E3Z27_RS00010	COG0592	DNA-directed DNA polymerase activity
E3Z27_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3Z27_RS00020	COG0187	DNA topoisomerase II activity
E3Z27_RS00030	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS00035	COG2205	protein histidine kinase activity
E3Z27_RS00050	COG0751	glycine-tRNA ligase activity
E3Z27_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
E3Z27_RS00060	COG2818	Glycosylase
E3Z27_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS00100	COG2011	ABC-type metal ion transport system permease component
E3Z27_RS00105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3Z27_RS00125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3Z27_RS00130	COG1121	(ABC) transporter
E3Z27_RS00135	COG0735	belongs to the Fur family
E3Z27_RS00140	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E3Z27_RS00160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E3Z27_RS00175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3Z27_RS00185	COG3706	GGDEF domain
E3Z27_RS00185	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS00190	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3Z27_RS00195	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E3Z27_RS00200	COG5002	protein histidine kinase activity
E3Z27_RS00205	COG2204	response regulator
E3Z27_RS00215	COG5487	UPF0391 membrane protein
E3Z27_RS00225	COG1301	dicarboxylic acid transport
E3Z27_RS00230	COG0700	Nucleoside recognition
E3Z27_RS00240	COG0612	Peptidase, M16
E3Z27_RS00245	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3Z27_RS00250	COG0861	Integral membrane protein TerC family
E3Z27_RS00255	COG2851	Citrate transporter
E3Z27_RS00275	COG3119	arylsulfatase activity
E3Z27_RS00290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3Z27_RS00295	COG0408	coproporphyrinogen oxidase activity
E3Z27_RS00305	COG0009	L-threonylcarbamoyladenylate synthase
E3Z27_RS00310	COG0758	DNA mediated transformation
E3Z27_RS00320	COG0242	peptide deformylase activity
E3Z27_RS00325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3Z27_RS00330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3Z27_RS00335	COG0569	domain protein
E3Z27_RS00355	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS00360	COG2205	protein histidine kinase activity
E3Z27_RS00460	COG0109	protoheme IX farnesyltransferase activity
E3Z27_RS00490	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E3Z27_RS00515	COG0659	secondary active sulfate transmembrane transporter activity
E3Z27_RS00535	COG0339	signal peptide processing
E3Z27_RS00540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E3Z27_RS00545	COG0339	signal peptide processing
E3Z27_RS00550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3Z27_RS00580	COG1764	response to oxidative stress
E3Z27_RS00585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3Z27_RS00595	COG3360	Dodecin
E3Z27_RS00610	COG0133	tryptophan synthase activity
E3Z27_RS00615	COG0159	tryptophan synthase activity
E3Z27_RS00645	COG0427	acetyl-CoA hydrolase
E3Z27_RS00650	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3Z27_RS00655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3Z27_RS00660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3Z27_RS00665	COG0583	DNA-binding transcription factor activity
E3Z27_RS00670	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS00720	COG1649	PFAM Uncharacterised BCR, COG1649
E3Z27_RS00720	COG0726	polysaccharide deacetylase
E3Z27_RS00725	COG1215	transferase activity, transferring glycosyl groups
E3Z27_RS00745	COG0477	Major facilitator Superfamily
E3Z27_RS00750	COG0583	DNA-binding transcription factor activity
E3Z27_RS00760	COG2304	oxidoreductase activity
E3Z27_RS00765	COG1595	DNA-templated transcription, initiation
E3Z27_RS00785	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS00790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS00795	COG5002	protein histidine kinase activity
E3Z27_RS00795	COG2205	protein histidine kinase activity
E3Z27_RS00795	COG0784	Response regulator, receiver
E3Z27_RS00800	COG3706	GGDEF domain
E3Z27_RS00800	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS00820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3Z27_RS00825	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E3Z27_RS00830	COG4208	sulfate ABC transporter
E3Z27_RS00835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E3Z27_RS00895	COG1595	DNA-templated transcription, initiation
E3Z27_RS00900	COG0840	transmembrane signaling receptor activity
E3Z27_RS00925	COG1802	Transcriptional regulator
E3Z27_RS00935	COG5001	Diguanylate cyclase
E3Z27_RS00935	COG3300	MHYT domain
E3Z27_RS00960	COG1538	Outer membrane efflux protein
E3Z27_RS00965	COG2274	protein secretion by the type I secretion system
E3Z27_RS00970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS00980	COG1090	epimerase
E3Z27_RS01055	COG0330	HflC and HflK could
E3Z27_RS01105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3Z27_RS01115	COG0789	Transcriptional regulator
E3Z27_RS01120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3Z27_RS01125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3Z27_RS01130	COG0730	response to heat
E3Z27_RS01145	COG0494	nUDIX hydrolase
E3Z27_RS01160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3Z27_RS01165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3Z27_RS01170	COG3204	pilus organization
E3Z27_RS01175	COG3204	pilus organization
E3Z27_RS01180	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3Z27_RS01185	COG0277	FAD linked oxidase domain protein
E3Z27_RS01190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3Z27_RS01200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS01210	COG2011	ABC-type metal ion transport system permease component
E3Z27_RS01215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3Z27_RS01220	COG1464	Belongs to the NlpA lipoprotein family
E3Z27_RS01260	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E3Z27_RS01265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3Z27_RS01290	COG0667	Aldo Keto reductase
E3Z27_RS01295	COG2175	clavaminate synthase activity
E3Z27_RS01300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3Z27_RS01305	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E3Z27_RS01310	COG4521	taurine ABC transporter
E3Z27_RS01315	COG2918	glutathione biosynthetic process
E3Z27_RS01325	COG2183	response to ionizing radiation
E3Z27_RS01330	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS01335	COG2205	protein histidine kinase activity
E3Z27_RS01340	COG0189	ligase activity
E3Z27_RS01345	COG4067	protein conserved in archaea
E3Z27_RS01345	COG0189	ligase activity
E3Z27_RS01350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3Z27_RS01355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3Z27_RS01360	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E3Z27_RS01375	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3Z27_RS01375	COG1024	Enoyl-CoA hydratase
E3Z27_RS01395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3Z27_RS01405	COG1652	LysM domain
E3Z27_RS01410	COG1011	Hydrolase
E3Z27_RS01415	COG0494	nUDIX hydrolase
E3Z27_RS01460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS01470	COG2957	Belongs to the agmatine deiminase family
E3Z27_RS01520	COG5642	Protein of unknown function (DUF2384)
E3Z27_RS01580	COG4804	nuclease activity
E3Z27_RS01605	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E3Z27_RS01630	COG0131	Imidazoleglycerol-phosphate dehydratase
E3Z27_RS01635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3Z27_RS01645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3Z27_RS01650	COG0107	imidazoleglycerol-phosphate synthase activity
E3Z27_RS01670	COG4942	peptidase
E3Z27_RS01675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3Z27_RS01690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3Z27_RS01695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3Z27_RS01710	COG3852	Histidine kinase
E3Z27_RS01735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3Z27_RS01735	COG0301	tRNA thio-modification
E3Z27_RS01750	COG0058	SHG alpha-glucan phosphorylase activity
E3Z27_RS01765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E3Z27_RS01795	COG3040	lipid binding
E3Z27_RS01800	COG0402	S-adenosylhomocysteine deaminase activity
E3Z27_RS01805	COG2188	Transcriptional regulator
E3Z27_RS01815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E3Z27_RS01820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3Z27_RS01830	COG4176	ABC-type proline glycine betaine transport system permease component
E3Z27_RS01835	COG4175	Glycine betaine
E3Z27_RS01835	COG0517	IMP dehydrogenase activity
E3Z27_RS01840	COG2986	histidine ammonia-lyase
E3Z27_RS01845	COG2986	histidine ammonia-lyase
E3Z27_RS01850	COG1228	amidohydrolase
E3Z27_RS01860	COG0596	Alpha beta hydrolase
E3Z27_RS01865	COG1490	D-aminoacyl-tRNA deacylase activity
E3Z27_RS01870	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E3Z27_RS01875	COG2943	transferase activity, transferring hexosyl groups
E3Z27_RS01885	COG0840	transmembrane signaling receptor activity
E3Z27_RS01890	COG0840	transmembrane signaling receptor activity
E3Z27_RS01905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z27_RS01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z27_RS01915	COG0140	phosphoribosyl-ATP diphosphatase activity
E3Z27_RS01925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3Z27_RS01935	COG2226	methyltransferase
E3Z27_RS01955	COG1309	transcriptional regulator
E3Z27_RS01980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E3Z27_RS01985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E3Z27_RS01995	COG0018	arginyl-trna synthetase
E3Z27_RS02005	COG0254	rRNA binding
E3Z27_RS02015	COG0281	malic enzyme
E3Z27_RS02050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3Z27_RS02055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3Z27_RS02065	COG0067	glutamate synthase
E3Z27_RS02065	COG0069	glutamate synthase activity
E3Z27_RS02065	COG0070	glutamate synthase
E3Z27_RS02070	COG0493	'glutamate synthase
E3Z27_RS02075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3Z27_RS02080	COG3397	chitin binding
E3Z27_RS02140	COG2814	Major facilitator Superfamily
E3Z27_RS02145	COG0583	DNA-binding transcription factor activity
E3Z27_RS02150	COG3657	addiction module killer protein
E3Z27_RS02155	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3Z27_RS02170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3Z27_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS02185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3Z27_RS02195	COG2226	methyltransferase
E3Z27_RS02200	COG3573	Dehydrogenase
E3Z27_RS02220	COG2986	histidine ammonia-lyase
E3Z27_RS02235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z27_RS02245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3Z27_RS02250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3Z27_RS02265	COG1192	Involved in chromosome partitioning
E3Z27_RS02270	COG3118	belongs to the thioredoxin family
E3Z27_RS02280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E3Z27_RS02285	COG1196	nuclear chromosome segregation
E3Z27_RS02285	COG3264	Mechanosensitive ion channel
E3Z27_RS02290	COG3263	regulation of cellular component size
E3Z27_RS02310	COG0840	transmembrane signaling receptor activity
E3Z27_RS02315	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS02320	COG0506	proline dehydrogenase activity
E3Z27_RS02320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3Z27_RS02320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3Z27_RS02325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3Z27_RS02335	COG3501	Rhs element vgr protein
E3Z27_RS02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E3Z27_RS02350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3Z27_RS02375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3Z27_RS02380	COG0859	PFAM glycosyl transferase family 9
E3Z27_RS02385	COG0859	PFAM glycosyl transferase family 9
E3Z27_RS02390	COG0438	transferase activity, transferring glycosyl groups
E3Z27_RS02415	COG2192	nodulation
E3Z27_RS02420	COG0438	transferase activity, transferring glycosyl groups
E3Z27_RS02445	COG1215	transferase activity, transferring glycosyl groups
E3Z27_RS02455	COG1132	(ABC) transporter
E3Z27_RS02460	COG0529	Catalyzes the synthesis of activated sulfate
E3Z27_RS02465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E3Z27_RS02465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3Z27_RS02490	COG0667	Aldo Keto reductase
E3Z27_RS02505	COG0583	DNA-binding transcription factor activity
E3Z27_RS02510	COG1519	Transferase
E3Z27_RS02515	COG1538	Outer membrane efflux protein
E3Z27_RS02520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E3Z27_RS02535	COG0494	nUDIX hydrolase
E3Z27_RS02545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3Z27_RS02555	COG3150	esterase
E3Z27_RS02585	COG0560	Phosphoserine phosphatase
E3Z27_RS02585	COG3830	Belongs to the UPF0237 family
E3Z27_RS02595	COG0688	phosphatidylethanolamine metabolic process
E3Z27_RS02615	COG1360	Flagellar Motor Protein
E3Z27_RS02625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3Z27_RS02630	COG2860	membrane
E3Z27_RS02640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3Z27_RS02640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3Z27_RS02645	COG0802	atpase or kinase
E3Z27_RS02650	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3Z27_RS02655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3Z27_RS02660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3Z27_RS02665	COG1923	regulation of RNA biosynthetic process
E3Z27_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3Z27_RS02675	COG0330	HflC and HflK could
E3Z27_RS02680	COG0330	HflC and HflK could
E3Z27_RS02685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E3Z27_RS02690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3Z27_RS02710	COG0557	exoribonuclease II activity
E3Z27_RS02715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3Z27_RS02720	COG0360	Binds together with S18 to 16S ribosomal RNA
E3Z27_RS02725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3Z27_RS02735	COG0359	binds to the 23S rRNA
E3Z27_RS02745	COG1032	radical SAM domain protein
E3Z27_RS02770	COG2307	Protein conserved in bacteria
E3Z27_RS02770	COG2308	Evidence 4 Homologs of previously reported genes of
E3Z27_RS02795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3Z27_RS02800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3Z27_RS02805	COG0583	DNA-binding transcription factor activity
E3Z27_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS02815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS02840	COG0410	ABC transporter
E3Z27_RS02845	COG4221	oxidoreductase activity
E3Z27_RS02860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E3Z27_RS02865	COG0830	nickel cation binding
E3Z27_RS02870	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E3Z27_RS02885	COG2982	Protein involved in outer membrane biogenesis
E3Z27_RS02895	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3Z27_RS02910	COG0443	Heat shock 70 kDa protein
E3Z27_RS02915	COG0484	heat shock protein binding
E3Z27_RS02920	COG0789	Transcriptional regulator
E3Z27_RS02930	COG0832	Belongs to the urease beta subunit family
E3Z27_RS02945	COG0831	urea catabolic process
E3Z27_RS02950	COG0829	nickel cation binding
E3Z27_RS02955	COG0410	ABC transporter
E3Z27_RS02960	COG0411	ABC transporter
E3Z27_RS02970	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3Z27_RS02975	COG0683	leucine binding
E3Z27_RS02980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3Z27_RS02990	COG1120	ATPase activity
E3Z27_RS03040	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E3Z27_RS03095	COG0151	Belongs to the GarS family
E3Z27_RS03100	COG0138	bifunctional purine biosynthesis protein purh
E3Z27_RS03110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3Z27_RS03120	COG2264	protein methyltransferase activity
E3Z27_RS03140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3Z27_RS03150	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS03150	COG3706	GGDEF domain
E3Z27_RS03165	COG0023	Translation Initiation Factor
E3Z27_RS03170	COG1166	arginine decarboxylase activity
E3Z27_RS03175	COG3501	Rhs element vgr protein
E3Z27_RS03185	COG0534	Mate efflux family protein
E3Z27_RS03215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3Z27_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS03250	COG2207	Transcriptional regulator
E3Z27_RS03265	COG2217	Heavy metal translocating P-type atpase
E3Z27_RS03290	COG0583	DNA-binding transcription factor activity
E3Z27_RS03300	COG0477	Major facilitator Superfamily
E3Z27_RS03305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3Z27_RS03310	COG0387	Pfam Sodium calcium exchanger
E3Z27_RS03340	COG1309	transcriptional regulator
E3Z27_RS03385	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3Z27_RS03390	COG1074	ATP-dependent DNA helicase activity
E3Z27_RS03395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3Z27_RS03450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3Z27_RS03465	COG0583	DNA-binding transcription factor activity
E3Z27_RS03480	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3Z27_RS03495	COG0659	secondary active sulfate transmembrane transporter activity
E3Z27_RS03500	COG2610	gluconate transmembrane transporter activity
E3Z27_RS03510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E3Z27_RS03540	COG0840	transmembrane signaling receptor activity
E3Z27_RS03595	COG0300	oxidoreductase activity
E3Z27_RS03600	COG2207	Transcriptional regulator
E3Z27_RS03620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3Z27_RS03645	COG1111	helicase
E3Z27_RS03645	COG1205	dead DEAH box helicase
E3Z27_RS03670	COG0582	viral genome integration into host DNA
E3Z27_RS03700	COG0247	lactate metabolic process
E3Z27_RS03705	COG1620	l-lactate permease
E3Z27_RS03710	COG2186	Transcriptional regulator
E3Z27_RS03715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3Z27_RS03720	COG0733	neurotransmitter:sodium symporter activity
E3Z27_RS03730	COG2914	Belongs to the UPF0125 (RnfH) family
E3Z27_RS03735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z27_RS03745	COG0497	DNA recombination
E3Z27_RS03750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3Z27_RS03755	COG0443	Heat shock 70 kDa protein
E3Z27_RS03760	COG0484	heat shock protein binding
E3Z27_RS03765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3Z27_RS03770	COG0505	Belongs to the CarA family
E3Z27_RS03775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3Z27_RS03780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z27_RS03795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E3Z27_RS03800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3Z27_RS03805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3Z27_RS03815	COG0149	triose-phosphate isomerase activity
E3Z27_RS03820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3Z27_RS03840	COG0195	Participates in both transcription termination and antitermination
E3Z27_RS03845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3Z27_RS03850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3Z27_RS03855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3Z27_RS03860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3Z27_RS03865	COG1185	polyribonucleotide nucleotidyltransferase activity
E3Z27_RS03895	COG3023	N-Acetylmuramoyl-L-alanine amidase
E3Z27_RS03910	COG0084	hydrolase, TatD family'
E3Z27_RS03915	COG1609	Transcriptional regulator
E3Z27_RS03925	COG1105	Belongs to the carbohydrate kinase PfkB family
E3Z27_RS03930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z27_RS03930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3Z27_RS03930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E3Z27_RS03945	COG4774	siderophore transport
E3Z27_RS03950	COG3128	pkhd-type hydroxylase
E3Z27_RS03960	COG0019	diaminopimelate decarboxylase activity
E3Z27_RS03985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3Z27_RS03995	COG4608	Belongs to the ABC transporter superfamily
E3Z27_RS04000	COG0444	Belongs to the ABC transporter superfamily
E3Z27_RS04005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z27_RS04010	COG0601	transmembrane transport
E3Z27_RS04015	COG0747	negative chemotaxis
E3Z27_RS04025	COG0747	negative chemotaxis
E3Z27_RS04030	COG0747	negative chemotaxis
E3Z27_RS04035	COG0747	negative chemotaxis
E3Z27_RS04055	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E3Z27_RS04060	COG4178	(ABC) transporter
E3Z27_RS04075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z27_RS04085	COG2271	Major facilitator Superfamily
E3Z27_RS04090	COG2721	sulfolactate sulfo-lyase activity
E3Z27_RS04100	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS04110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3Z27_RS04115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3Z27_RS04120	COG0154	amidase activity
E3Z27_RS04125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3Z27_RS04130	COG1077	Cell shape determining protein MreB Mrl
E3Z27_RS04135	COG1792	Involved in formation and maintenance of cell shape
E3Z27_RS04145	COG0424	maF-like protein
E3Z27_RS04150	COG1530	ribonuclease E activity
E3Z27_RS04160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3Z27_RS04165	COG0312	modulator of DNA gyrase
E3Z27_RS04170	COG3028	Belongs to the UPF0307 family
E3Z27_RS04175	COG0312	modulator of DNA gyrase
E3Z27_RS04205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z27_RS04210	COG1660	Displays ATPase and GTPase activities
E3Z27_RS04225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3Z27_RS04230	COG1137	ATPase activity
E3Z27_RS04235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E3Z27_RS04245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3Z27_RS04255	COG1127	ABC transporter
E3Z27_RS04260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3Z27_RS04265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3Z27_RS04280	COG5007	Belongs to the BolA IbaG family
E3Z27_RS04285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3Z27_RS04290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3Z27_RS04295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3Z27_RS04300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3Z27_RS04315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3Z27_RS04325	COG0175	sulfate reduction
E3Z27_RS04340	COG0204	Acyl-transferase
E3Z27_RS04345	COG0857	belongs to the CobB CobQ family
E3Z27_RS04345	COG0280	phosphate acetyltransferase
E3Z27_RS04360	COG0386	Belongs to the glutathione peroxidase family
E3Z27_RS04375	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
E3Z27_RS04380	COG0492	ferredoxin-NADP+ reductase activity
E3Z27_RS04385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS04400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3Z27_RS04405	COG0302	gtp cyclohydrolase
E3Z27_RS04425	COG1366	Belongs to the anti-sigma-factor antagonist family
E3Z27_RS04440	COG0596	Alpha beta hydrolase
E3Z27_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS04480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E3Z27_RS04485	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3Z27_RS04505	COG3135	benzoate transporter
E3Z27_RS04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS04540	COG0697	spore germination
E3Z27_RS04565	COG3604	Transcriptional regulator
E3Z27_RS04570	COG1017	nitric oxide dioxygenase activity
E3Z27_RS04570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z27_RS04575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3Z27_RS04580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3Z27_RS04585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3Z27_RS04590	COG1845	cytochrome c oxidase, subunit III
E3Z27_RS04600	COG0109	protoheme IX farnesyltransferase activity
E3Z27_RS04615	COG0583	DNA-binding transcription factor activity
E3Z27_RS04620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3Z27_RS04750	COG2205	protein histidine kinase activity
E3Z27_RS04750	COG2198	Histidine kinase
E3Z27_RS04750	COG0784	Response regulator, receiver
E3Z27_RS04755	COG4771	TonB-dependent receptor
E3Z27_RS04790	COG4568	rho-dependent transcription termination
E3Z27_RS04795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z27_RS04800	COG0235	Class ii aldolase
E3Z27_RS04805	COG1396	sequence-specific DNA binding
E3Z27_RS04830	COG0583	DNA-binding transcription factor activity
E3Z27_RS04870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E3Z27_RS04875	COG0343	queuine tRNA-ribosyltransferase activity
E3Z27_RS04880	COG1862	Preprotein translocase
E3Z27_RS04895	COG3134	Outer membrane lipoprotein
E3Z27_RS04910	COG1045	serine acetyltransferase
E3Z27_RS04920	COG1104	cysteine desulfurase activity
E3Z27_RS04935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3Z27_RS04940	COG0443	Heat shock 70 kDa protein
E3Z27_RS04945	COG0633	Ferredoxin
E3Z27_RS04955	COG0105	UTP biosynthetic process
E3Z27_RS04960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3Z27_RS04975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3Z27_RS04980	COG0124	histidyl-tRNA synthetase
E3Z27_RS04995	COG1160	GTP binding
E3Z27_RS05000	COG0436	Aminotransferase
E3Z27_RS05015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3Z27_RS05020	COG0739	heme binding
E3Z27_RS05025	COG1570	exodeoxyribonuclease VII activity
E3Z27_RS05045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3Z27_RS05045	COG0519	Catalyzes the synthesis of GMP from XMP
E3Z27_RS05050	COG0583	DNA-binding transcription factor activity
E3Z27_RS05065	COG1309	transcriptional regulator
E3Z27_RS05070	COG0492	ferredoxin-NADP+ reductase activity
E3Z27_RS05080	COG2188	Transcriptional regulator
E3Z27_RS05085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z27_RS05085	COG1263	PTS System
E3Z27_RS05090	COG0366	Alpha amylase catalytic
E3Z27_RS05100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z27_RS05100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z27_RS05145	COG0590	tRNA wobble adenosine to inosine editing
E3Z27_RS05150	COG0500	methyltransferase
E3Z27_RS05155	COG4106	trans-aconitate 2-methyltransferase activity
E3Z27_RS05160	COG4571	Outer membrane protease
E3Z27_RS05170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3Z27_RS05175	COG0477	Major facilitator Superfamily
E3Z27_RS05180	COG4536	flavin adenine dinucleotide binding
E3Z27_RS05190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3Z27_RS05195	COG0228	four-way junction DNA binding
E3Z27_RS05200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3Z27_RS05205	COG0336	Belongs to the RNA methyltransferase TrmD family
E3Z27_RS05210	COG0335	large ribosomal subunit rRNA binding
E3Z27_RS05235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS05235	COG2205	protein histidine kinase activity
E3Z27_RS05250	COG4681	YaeQ
E3Z27_RS05260	COG1902	pentaerythritol trinitrate reductase activity
E3Z27_RS05265	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E3Z27_RS05285	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS05290	COG1177	transmembrane transport
E3Z27_RS05295	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z27_RS05300	COG3842	ATPase activity
E3Z27_RS05305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3Z27_RS05315	COG0583	DNA-binding transcription factor activity
E3Z27_RS05335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3Z27_RS05335	COG0457	Tetratricopeptide repeat
E3Z27_RS05350	COG2201	protein-glutamate methylesterase activity
E3Z27_RS05355	COG4251	negative regulation of phosphorylation
E3Z27_RS05355	COG5001	Diguanylate cyclase
E3Z27_RS05355	COG3706	GGDEF domain
E3Z27_RS05355	COG2203	Gaf domain
E3Z27_RS05365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3Z27_RS05385	COG1073	alpha beta
E3Z27_RS05395	COG2885	chlorophyll binding
E3Z27_RS05410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E3Z27_RS05415	COG0563	adenylate kinase activity
E3Z27_RS05420	COG1214	PFAM Peptidase M22, glycoprotease
E3Z27_RS05430	COG1801	Protein of unknown function DUF72
E3Z27_RS05435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3Z27_RS05450	COG0742	ribosomal rna small subunit methyltransferase
E3Z27_RS05460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS05475	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E3Z27_RS05480	COG2937	Belongs to the GPAT DAPAT family
E3Z27_RS05495	COG2226	methyltransferase
E3Z27_RS05500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3Z27_RS05505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3Z27_RS05510	COG2166	iron-sulfur cluster assembly
E3Z27_RS05515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3Z27_RS05520	COG2171	N-acyltransferase activity
E3Z27_RS05525	COG1393	Belongs to the ArsC family
E3Z27_RS05530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E3Z27_RS05545	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
E3Z27_RS05550	COG0436	Aminotransferase
E3Z27_RS05555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3Z27_RS05560	COG0024	Methionine aminopeptidase
E3Z27_RS05570	COG0052	Belongs to the universal ribosomal protein uS2 family
E3Z27_RS05575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3Z27_RS05580	COG0528	UMP kinase activity
E3Z27_RS05585	COG0233	cytoplasmic translational termination
E3Z27_RS05590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3Z27_RS05600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3Z27_RS05620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3Z27_RS05625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3Z27_RS05630	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3Z27_RS05635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3Z27_RS05640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3Z27_RS05645	COG0587	DNA-directed DNA polymerase activity
E3Z27_RS05650	COG0825	malonyl-CoA metabolic process
E3Z27_RS05655	COG0037	tRNA processing
E3Z27_RS05665	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E3Z27_RS05670	COG0148	phosphopyruvate hydratase activity
E3Z27_RS05680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3Z27_RS05690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E3Z27_RS05695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E3Z27_RS05700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E3Z27_RS05705	COG0585	pseudouridine synthase activity
E3Z27_RS05710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E3Z27_RS05715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3Z27_RS05730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3Z27_RS05735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3Z27_RS05855	COG4386	tail sheath protein
E3Z27_RS05895	COG4381	Mu-like prophage protein gp46
E3Z27_RS05920	COG3179	chitinase
E3Z27_RS05930	COG1546	Belongs to the CinA family
E3Z27_RS05935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3Z27_RS05940	COG2137	regulation of response to DNA damage stimulus
E3Z27_RS05975	COG0583	DNA-binding transcription factor activity
E3Z27_RS05990	COG4807	Protein conserved in bacteria
E3Z27_RS05995	COG1187	pseudouridine synthase activity
E3Z27_RS06000	COG0519	Catalyzes the synthesis of GMP from XMP
E3Z27_RS06005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3Z27_RS06010	COG3158	transport of potassium into the cell
E3Z27_RS06020	COG0546	phosphoglycolate phosphatase activity
E3Z27_RS06035	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E3Z27_RS06035	COG0392	lysyltransferase activity
E3Z27_RS06050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3Z27_RS06060	COG0442	prolyl-tRNA aminoacylation
E3Z27_RS06080	COG1278	Cold shock
E3Z27_RS06085	COG0717	Belongs to the dCTP deaminase family
E3Z27_RS06100	COG1201	RNA secondary structure unwinding
E3Z27_RS06105	COG4598	ABC transporter
E3Z27_RS06115	COG4160	amino acid transport
E3Z27_RS06120	COG4215	(ABC) transporter
E3Z27_RS06130	COG1793	dna ligase
E3Z27_RS06145	COG0625	glutathione transferase activity
E3Z27_RS06155	COG0653	protein targeting
E3Z27_RS06165	COG3012	SEC-C Motif Domain Protein
E3Z27_RS06195	COG1199	ATP-dependent helicase activity
E3Z27_RS06205	COG2885	chlorophyll binding
E3Z27_RS06210	COG0259	pyridoxamine-phosphate oxidase activity
E3Z27_RS06225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3Z27_RS06235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E3Z27_RS06250	COG0583	DNA-binding transcription factor activity
E3Z27_RS06265	COG3220	belongs to the UPF0276 family
E3Z27_RS06315	COG2271	Major facilitator Superfamily
E3Z27_RS06345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3Z27_RS06360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3Z27_RS06365	COG2832	Protein of unknown function (DUF454)
E3Z27_RS06380	COG3712	iron ion homeostasis
E3Z27_RS06405	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS06410	COG2205	protein histidine kinase activity
E3Z27_RS06420	COG1653	transport
E3Z27_RS06430	COG0395	ABC-type sugar transport system, permease component
E3Z27_RS06445	COG0676	glucose-6-phosphate 1-epimerase activity
E3Z27_RS06450	COG1737	Transcriptional regulator
E3Z27_RS06465	COG0800	Aldolase
E3Z27_RS06475	COG3530	Putative quorum-sensing-regulated virulence factor
E3Z27_RS06495	COG1566	PFAM secretion protein HlyD family protein
E3Z27_RS06500	COG2030	dehydratase
E3Z27_RS06505	COG2267	carboxylic ester hydrolase activity
E3Z27_RS06510	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z27_RS06525	COG1295	ribonuclease BN
E3Z27_RS06530	COG0242	peptide deformylase activity
E3Z27_RS06545	COG1609	Transcriptional regulator
E3Z27_RS06550	COG3265	gluconokinase activity
E3Z27_RS06560	COG0436	Aminotransferase
E3Z27_RS06585	COG3795	YCII-related domain
E3Z27_RS06595	COG4941	Belongs to the sigma-70 factor family
E3Z27_RS06610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3Z27_RS06625	COG0583	DNA-binding transcription factor activity
E3Z27_RS06630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3Z27_RS06640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3Z27_RS06650	COG0306	phosphate transporter
E3Z27_RS06660	COG1414	Transcriptional regulator
E3Z27_RS06665	COG2814	Major facilitator Superfamily
E3Z27_RS06670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3Z27_RS06675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3Z27_RS06680	COG0183	Belongs to the thiolase family
E3Z27_RS06685	COG3485	protocatechuate 3,4-dioxygenase
E3Z27_RS06690	COG3485	protocatechuate 3,4-dioxygenase
E3Z27_RS06695	COG0477	Major facilitator Superfamily
E3Z27_RS06705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3Z27_RS06710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS06725	COG1538	Outer membrane efflux protein
E3Z27_RS06735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS06750	COG1902	pentaerythritol trinitrate reductase activity
E3Z27_RS06755	COG2814	Major facilitator Superfamily
E3Z27_RS06795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3Z27_RS06805	COG1704	LemA family
E3Z27_RS06810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3Z27_RS06825	COG0693	protein deglycase activity
E3Z27_RS06830	COG3422	double-strand break repair
E3Z27_RS06840	COG1454	alcohol dehydrogenase
E3Z27_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS06900	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS06925	COG3706	GGDEF domain
E3Z27_RS06925	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS06935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E3Z27_RS06940	COG3180	Ammonia monooxygenase
E3Z27_RS06965	COG0642	Histidine kinase
E3Z27_RS06980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3Z27_RS07010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3Z27_RS07020	COG0425	Belongs to the sulfur carrier protein TusA family
E3Z27_RS07030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3Z27_RS07040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z27_RS07045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3Z27_RS07050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3Z27_RS07055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3Z27_RS07080	COG0662	Cupin 2, conserved barrel domain protein
E3Z27_RS07105	COG0174	glutamine synthetase
E3Z27_RS07110	COG2194	sulfuric ester hydrolase activity
E3Z27_RS07125	COG3100	YcgL domain-containing protein
E3Z27_RS07135	COG2983	Belongs to the UPF0260 family
E3Z27_RS07155	COG1403	HNH endonuclease
E3Z27_RS07185	COG0121	glutamine amidotransferase
E3Z27_RS07200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E3Z27_RS07205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3Z27_RS07210	COG1984	allophanate hydrolase subunit 2
E3Z27_RS07220	COG0542	response to heat
E3Z27_RS07250	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E3Z27_RS07255	COG1643	Atp-dependent helicase
E3Z27_RS07265	COG1595	DNA-templated transcription, initiation
E3Z27_RS07275	COG2188	Transcriptional regulator
E3Z27_RS07285	COG1132	(ABC) transporter
E3Z27_RS07295	COG0596	Alpha beta hydrolase
E3Z27_RS07310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3Z27_RS07325	COG0583	DNA-binding transcription factor activity
E3Z27_RS07330	COG1335	isochorismatase
E3Z27_RS07375	COG0210	DNA helicase
E3Z27_RS07380	COG1196	nuclear chromosome segregation
E3Z27_RS07500	COG0513	Belongs to the DEAD box helicase family
E3Z27_RS07570	COG2996	Protein conserved in bacteria
E3Z27_RS07575	COG1953	Uracil, thiamine, allantoin
E3Z27_RS07585	COG0583	DNA-binding transcription factor activity
E3Z27_RS07620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS07655	COG2832	Protein of unknown function (DUF454)
E3Z27_RS07665	COG0514	ATP-dependent DNA helicase (RecQ)
E3Z27_RS07680	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3Z27_RS07715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3Z27_RS07730	COG2154	pterin-4-alpha-carbinolamine dehydratase
E3Z27_RS07740	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E3Z27_RS07745	COG1216	Glycosyl transferase, family 2
E3Z27_RS07745	COG0438	transferase activity, transferring glycosyl groups
E3Z27_RS07780	COG4786	Flagellar basal body rod
E3Z27_RS07785	COG4786	Flagellar basal body rod
E3Z27_RS07790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E3Z27_RS07795	COG1706	bacterial-type flagellum-dependent cell motility
E3Z27_RS07805	COG1256	bacterial-type flagellum assembly
E3Z27_RS07820	COG0438	transferase activity, transferring glycosyl groups
E3Z27_RS07820	COG1216	Glycosyl transferase, family 2
E3Z27_RS07830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3Z27_RS07855	COG2204	response regulator
E3Z27_RS07870	COG1677	Flagellar hook-basal body complex protein FliE
E3Z27_RS07905	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS07960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3Z27_RS07970	COG0455	bacterial-type flagellum organization
E3Z27_RS07985	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E3Z27_RS07990	COG0643	Histidine kinase
E3Z27_RS07990	COG2198	Histidine kinase
E3Z27_RS07995	COG2201	protein-glutamate methylesterase activity
E3Z27_RS08000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3Z27_RS08010	COG1192	Involved in chromosome partitioning
E3Z27_RS08020	COG0835	chemotaxis
E3Z27_RS08045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3Z27_RS08055	COG4133	protoheme IX ABC transporter activity
E3Z27_RS08075	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E3Z27_RS08080	COG1138	Cytochrome C-type biogenesis protein
E3Z27_RS08105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E3Z27_RS08110	COG1368	sulfuric ester hydrolase activity
E3Z27_RS08125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3Z27_RS08130	COG3089	Belongs to the UPF0270 family
E3Z27_RS08135	COG1363	Peptidase, m42
E3Z27_RS08145	COG0367	asparagine synthase
E3Z27_RS08150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E3Z27_RS08150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS08155	COG2326	polyphosphate kinase activity
E3Z27_RS08160	COG0183	Belongs to the thiolase family
E3Z27_RS08170	COG0697	spore germination
E3Z27_RS08175	COG0114	fumarate hydratase activity
E3Z27_RS08185	COG0271	Belongs to the BolA IbaG family
E3Z27_RS08200	COG1132	(ABC) transporter
E3Z27_RS08205	COG5002	protein histidine kinase activity
E3Z27_RS08205	COG5001	Diguanylate cyclase
E3Z27_RS08215	COG3706	GGDEF domain
E3Z27_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS08225	COG0546	phosphoglycolate phosphatase activity
E3Z27_RS08230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3Z27_RS08235	COG0402	S-adenosylhomocysteine deaminase activity
E3Z27_RS08240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E3Z27_RS08250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3Z27_RS08260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3Z27_RS08265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3Z27_RS08270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3Z27_RS08285	COG0776	regulation of translation
E3Z27_RS08335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3Z27_RS08340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3Z27_RS08345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3Z27_RS08350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3Z27_RS08355	COG2089	acid synthase
E3Z27_RS08360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3Z27_RS08365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3Z27_RS08375	COG0107	imidazoleglycerol-phosphate synthase activity
E3Z27_RS08385	COG1083	cytidylyl-transferase
E3Z27_RS08400	COG0110	maltose O-acetyltransferase activity
E3Z27_RS08430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3Z27_RS08440	COG1555	photosystem II stabilization
E3Z27_RS08440	COG1596	polysaccharide export
E3Z27_RS08465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E3Z27_RS08475	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E3Z27_RS08480	COG2205	protein histidine kinase activity
E3Z27_RS08520	COG0084	hydrolase, TatD family'
E3Z27_RS08525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3Z27_RS08530	COG2259	Doxx family
E3Z27_RS08550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3Z27_RS08555	COG4181	ATPase activity
E3Z27_RS08570	COG1376	ErfK ybiS ycfS ynhG family protein
E3Z27_RS08585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3Z27_RS08590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3Z27_RS08610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z27_RS08625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3Z27_RS08635	COG1764	response to oxidative stress
E3Z27_RS08640	COG1846	Transcriptional regulator
E3Z27_RS08650	COG0583	DNA-binding transcription factor activity
E3Z27_RS08660	COG3214	Protein conserved in bacteria
E3Z27_RS08665	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E3Z27_RS08680	COG3384	dioxygenase
E3Z27_RS08685	COG0500	methyltransferase
E3Z27_RS08690	COG0501	Belongs to the peptidase M48B family
E3Z27_RS08700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3Z27_RS08705	COG0386	Belongs to the glutathione peroxidase family
E3Z27_RS08710	COG1846	Transcriptional regulator
E3Z27_RS08715	COG5002	protein histidine kinase activity
E3Z27_RS08715	COG0784	Response regulator, receiver
E3Z27_RS08715	COG2205	protein histidine kinase activity
E3Z27_RS08725	COG1956	GAF domain-containing protein
E3Z27_RS08730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E3Z27_RS08730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E3Z27_RS08735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS08735	COG2205	protein histidine kinase activity
E3Z27_RS08740	COG2197	response regulator
E3Z27_RS08765	COG0004	ammonium transporteR
E3Z27_RS08785	COG0564	pseudouridine synthase activity
E3Z27_RS08795	COG0746	molybdenum cofactor guanylyltransferase activity
E3Z27_RS08800	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3Z27_RS08805	COG0303	'Molybdopterin
E3Z27_RS08815	COG1597	lipid kinase activity
E3Z27_RS08820	COG2197	response regulator
E3Z27_RS08840	COG3217	Mosc domain protein beta barrel domain protein
E3Z27_RS08840	COG0633	Ferredoxin
E3Z27_RS08845	COG3123	guanosine phosphorylase activity
E3Z27_RS08870	COG2267	carboxylic ester hydrolase activity
E3Z27_RS08880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3Z27_RS08890	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS08895	COG0642	Histidine kinase
E3Z27_RS08905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E3Z27_RS08920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3Z27_RS08935	COG0668	transmembrane transport
E3Z27_RS08950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3Z27_RS08955	COG0243	molybdopterin cofactor binding
E3Z27_RS08960	COG2146	nitrite reductase [NAD(P)H] activity
E3Z27_RS08965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3Z27_RS08970	COG0515	serine threonine protein kinase
E3Z27_RS08975	COG2223	nitrite transmembrane transporter activity
E3Z27_RS08980	COG3707	response regulator
E3Z27_RS08985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3Z27_RS08985	COG1116	anion transmembrane transporter activity
E3Z27_RS08990	COG0167	dihydroorotate dehydrogenase activity
E3Z27_RS08995	COG3130	regulation of translation
E3Z27_RS09005	COG3706	GGDEF domain
E3Z27_RS09005	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS09010	COG2027	D-alanyl-D-alanine carboxypeptidase
E3Z27_RS09015	COG3171	Protein conserved in bacteria
E3Z27_RS09020	COG3135	benzoate transporter
E3Z27_RS09025	COG1802	Transcriptional regulator
E3Z27_RS09030	COG0402	S-adenosylhomocysteine deaminase activity
E3Z27_RS09055	COG1196	nuclear chromosome segregation
E3Z27_RS09060	COG3115	cell septum assembly
E3Z27_RS09065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3Z27_RS09100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3Z27_RS09105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3Z27_RS09110	COG2130	NADP-dependent
E3Z27_RS09115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3Z27_RS09120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3Z27_RS09125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z27_RS09165	COG3209	COG3209 Rhs family protein
E3Z27_RS09180	COG2010	Cytochrome c
E3Z27_RS09195	COG3278	Belongs to the heme-copper respiratory oxidase family
E3Z27_RS09215	COG3278	Belongs to the heme-copper respiratory oxidase family
E3Z27_RS09225	COG0840	transmembrane signaling receptor activity
E3Z27_RS09240	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E3Z27_RS09245	COG0425	Belongs to the sulfur carrier protein TusA family
E3Z27_RS09255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3Z27_RS09265	COG1132	(ABC) transporter
E3Z27_RS09275	COG0741	lytic transglycosylase activity
E3Z27_RS09285	COG0589	response to stress
E3Z27_RS09295	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3Z27_RS09295	COG1024	Enoyl-CoA hydratase
E3Z27_RS09300	COG0183	Belongs to the thiolase family
E3Z27_RS09345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3Z27_RS09350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3Z27_RS09360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3Z27_RS09375	COG1477	protein flavinylation
E3Z27_RS09385	COG0584	glycerophosphoryl diester phosphodiesterase
E3Z27_RS09395	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3Z27_RS09400	COG1136	(ABC) transporter
E3Z27_RS09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3Z27_RS09425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3Z27_RS09425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3Z27_RS09440	COG2853	Lipoprotein
E3Z27_RS09445	COG2204	response regulator
E3Z27_RS09455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3Z27_RS09460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3Z27_RS09470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3Z27_RS09480	COG2184	nucleotidyltransferase activity
E3Z27_RS09500	COG1335	isochorismatase
E3Z27_RS09505	COG0583	DNA-binding transcription factor activity
E3Z27_RS09530	COG2207	Transcriptional regulator
E3Z27_RS09560	COG1301	dicarboxylic acid transport
E3Z27_RS09580	COG0668	transmembrane transport
E3Z27_RS09600	COG3706	GGDEF domain
E3Z27_RS09600	COG4251	negative regulation of phosphorylation
E3Z27_RS09600	COG5001	Diguanylate cyclase
E3Z27_RS09600	COG2203	Gaf domain
E3Z27_RS09605	COG3300	MHYT domain
E3Z27_RS09605	COG5001	Diguanylate cyclase
E3Z27_RS09610	COG0708	Exodeoxyribonuclease III
E3Z27_RS09630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3Z27_RS09635	COG3132	Protein of unknown function, DUF480
E3Z27_RS09650	COG2814	Major facilitator Superfamily
E3Z27_RS09655	COG0583	DNA-binding transcription factor activity
E3Z27_RS09665	COG1253	flavin adenine dinucleotide binding
E3Z27_RS09680	COG1686	Belongs to the peptidase S11 family
E3Z27_RS09685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3Z27_RS09705	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3Z27_RS09710	COG0740	serine-type endopeptidase activity
E3Z27_RS09715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3Z27_RS09720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3Z27_RS09725	COG0776	regulation of translation
E3Z27_RS09730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z27_RS09755	COG1902	pentaerythritol trinitrate reductase activity
E3Z27_RS09755	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3Z27_RS09765	COG3038	cytochrome b561
E3Z27_RS09770	COG3501	Rhs element vgr protein
E3Z27_RS09775	COG0217	transcriptional regulatory protein
E3Z27_RS09805	COG1177	transmembrane transport
E3Z27_RS09810	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z27_RS09815	COG3842	ATPase activity
E3Z27_RS09820	COG1414	Transcriptional regulator
E3Z27_RS09830	COG1595	DNA-templated transcription, initiation
E3Z27_RS09840	COG3038	cytochrome b561
E3Z27_RS09845	COG2866	Carboxypeptidase
E3Z27_RS09865	COG1024	Enoyl-CoA hydratase
E3Z27_RS09870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3Z27_RS09875	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS09880	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z27_RS09890	COG0789	Transcriptional regulator
E3Z27_RS09900	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS09905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3Z27_RS09935	COG0531	amino acid
E3Z27_RS09950	COG1335	isochorismatase
E3Z27_RS09975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3Z27_RS09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS10005	COG3248	Nucleoside-binding outer membrane protein
E3Z27_RS10015	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E3Z27_RS10020	COG0701	Predicted permease
E3Z27_RS10030	COG0625	glutathione transferase activity
E3Z27_RS10035	COG0384	phenazine biosynthesis protein PhzF
E3Z27_RS10040	COG0113	porphobilinogen synthase activity
E3Z27_RS10065	COG3008	intermembrane lipid transfer
E3Z27_RS10070	COG2995	paraquat-inducible protein a
E3Z27_RS10080	COG0517	IMP dehydrogenase activity
E3Z27_RS10085	COG0417	DNA replication proofreading
E3Z27_RS10090	COG1522	sequence-specific DNA binding
E3Z27_RS10115	COG1538	Outer membrane efflux protein
E3Z27_RS10135	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS10140	COG2205	protein histidine kinase activity
E3Z27_RS10165	COG1735	metal-dependent hydrolase with the TIM-barrel fold
E3Z27_RS10180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS10190	COG0174	glutamine synthetase
E3Z27_RS10210	COG0656	L-ascorbic acid biosynthetic process
E3Z27_RS10225	COG0730	response to heat
E3Z27_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS10255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS10260	COG0348	domain, Protein
E3Z27_RS10270	COG1285	pathogenesis
E3Z27_RS10285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3Z27_RS10300	COG2186	Transcriptional regulator
E3Z27_RS10315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3Z27_RS10320	COG0583	DNA-binding transcription factor activity
E3Z27_RS10325	COG3685	Protein conserved in bacteria
E3Z27_RS10345	COG3546	catalase activity
E3Z27_RS10365	COG2066	Belongs to the glutaminase family
E3Z27_RS10375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3Z27_RS10380	COG2204	response regulator
E3Z27_RS10400	COG3245	cytochrome
E3Z27_RS10430	COG2081	HI0933 family
E3Z27_RS10445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3Z27_RS10465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3Z27_RS10480	COG0587	DNA-directed DNA polymerase activity
E3Z27_RS10485	COG4191	Histidine kinase
E3Z27_RS10485	COG0784	Response regulator, receiver
E3Z27_RS10510	COG1024	Enoyl-CoA hydratase
E3Z27_RS10510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3Z27_RS10525	COG0616	signal peptide processing
E3Z27_RS10555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3Z27_RS10555	COG0316	Belongs to the HesB IscA family
E3Z27_RS10610	COG2026	Addiction module toxin, RelE StbE family
E3Z27_RS10615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS10620	COG0765	amino acid transport
E3Z27_RS10625	COG0765	amino acid transport
E3Z27_RS10630	COG1126	abc transporter atp-binding protein
E3Z27_RS10650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z27_RS10655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z27_RS10670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3Z27_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS10680	COG2610	gluconate transmembrane transporter activity
E3Z27_RS10685	COG3604	Transcriptional regulator
E3Z27_RS10705	COG4239	(ABC) transporter, permease
E3Z27_RS10710	COG4174	ABC transporter (Permease)
E3Z27_RS10715	COG4166	transmembrane transport
E3Z27_RS10720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z27_RS10725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3Z27_RS10735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3Z27_RS10745	COG2197	response regulator
E3Z27_RS10750	COG0322	excinuclease ABC activity
E3Z27_RS10765	COG0582	viral genome integration into host DNA
E3Z27_RS10985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3Z27_RS11040	COG0066	3-isopropylmalate dehydratase activity
E3Z27_RS11045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3Z27_RS11050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3Z27_RS11060	COG0583	DNA-binding transcription factor activity
E3Z27_RS11070	COG0596	Alpha beta hydrolase
E3Z27_RS11090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3Z27_RS11095	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E3Z27_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS11140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z27_RS11150	COG3604	Transcriptional regulator
E3Z27_RS11165	COG2207	Transcriptional regulator
E3Z27_RS11220	COG2433	Pfam Transposase IS66
E3Z27_RS11250	COG0840	transmembrane signaling receptor activity
E3Z27_RS11280	COG2873	o-acetylhomoserine
E3Z27_RS11285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3Z27_RS11305	COG2986	histidine ammonia-lyase
E3Z27_RS11310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E3Z27_RS11320	COG4160	amino acid transport
E3Z27_RS11325	COG4215	(ABC) transporter
E3Z27_RS11330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS11340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3Z27_RS11355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS11360	COG0840	transmembrane signaling receptor activity
E3Z27_RS11375	COG2010	Cytochrome c
E3Z27_RS11400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS11415	COG0625	glutathione transferase activity
E3Z27_RS11440	COG3609	addiction module antidote protein, CC2985 family
E3Z27_RS11445	COG2271	Major facilitator Superfamily
E3Z27_RS11450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3Z27_RS11455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3Z27_RS11485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3Z27_RS11490	COG0066	3-isopropylmalate dehydratase activity
E3Z27_RS11495	COG0583	DNA-binding transcription factor activity
E3Z27_RS11520	COG2851	Citrate transporter
E3Z27_RS11530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3Z27_RS11565	COG1881	PFAM PEBP family protein
E3Z27_RS11570	COG2207	Transcriptional regulator
E3Z27_RS11605	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS11610	COG0642	Histidine kinase
E3Z27_RS11630	COG0589	response to stress
E3Z27_RS11640	COG0589	response to stress
E3Z27_RS11655	COG0589	response to stress
E3Z27_RS11660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E3Z27_RS11665	COG0071	Belongs to the small heat shock protein (HSP20) family
E3Z27_RS11675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z27_RS11685	COG0842	Transport permease protein
E3Z27_RS11690	COG1129	ABC transporter
E3Z27_RS11690	COG0842	Transport permease protein
E3Z27_RS11695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS11700	COG4650	regulator
E3Z27_RS11705	COG1690	Belongs to the RtcB family
E3Z27_RS11710	COG0430	RNA-3'-phosphate cyclase activity
E3Z27_RS11715	COG2207	Transcriptional regulator
E3Z27_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS11735	COG0583	DNA-binding transcription factor activity
E3Z27_RS11745	COG4221	oxidoreductase activity
E3Z27_RS11770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3Z27_RS11815	COG2259	Doxx family
E3Z27_RS11830	COG0583	DNA-binding transcription factor activity
E3Z27_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS11840	COG0247	lactate metabolic process
E3Z27_RS11845	COG0277	FAD linked oxidase domain protein
E3Z27_RS11850	COG0277	FAD linked oxidase domain protein
E3Z27_RS11855	COG2186	Transcriptional regulator
E3Z27_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS11910	COG1802	Transcriptional regulator
E3Z27_RS11920	COG4175	Glycine betaine
E3Z27_RS11920	COG3448	diguanylate cyclase activity
E3Z27_RS11925	COG4176	ABC-type proline glycine betaine transport system permease component
E3Z27_RS11935	COG3938	Belongs to the proline racemase family
E3Z27_RS11950	COG0723	plastoquinol--plastocyanin reductase activity
E3Z27_RS11950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS11955	COG2271	Major facilitator Superfamily
E3Z27_RS11960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z27_RS11965	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS11980	COG0583	DNA-binding transcription factor activity
E3Z27_RS11995	COG1215	transferase activity, transferring glycosyl groups
E3Z27_RS12000	COG1215	transferase activity, transferring glycosyl groups
E3Z27_RS12005	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E3Z27_RS12010	COG0457	Tetratricopeptide repeat
E3Z27_RS12045	COG1063	alcohol dehydrogenase
E3Z27_RS12050	COG4178	(ABC) transporter
E3Z27_RS12065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z27_RS12100	COG4774	siderophore transport
E3Z27_RS12100	COG1629	transport
E3Z27_RS12120	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS12135	COG0531	amino acid
E3Z27_RS12150	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS12175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS12180	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS12185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3Z27_RS12190	COG1846	Transcriptional regulator
E3Z27_RS12200	COG3971	2-oxopent-4-enoate hydratase activity
E3Z27_RS12205	COG2271	Major facilitator Superfamily
E3Z27_RS12215	COG3384	dioxygenase
E3Z27_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS12240	COG1846	Transcriptional regulator
E3Z27_RS12280	COG0277	FAD linked oxidase domain protein
E3Z27_RS12280	COG0247	lactate metabolic process
E3Z27_RS12285	COG0596	Alpha beta hydrolase
E3Z27_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS12310	COG1764	response to oxidative stress
E3Z27_RS12320	COG4191	Histidine kinase
E3Z27_RS12330	COG4566	intracellular signal transduction
E3Z27_RS12340	COG1764	response to oxidative stress
E3Z27_RS12405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3Z27_RS12410	COG0667	Aldo Keto reductase
E3Z27_RS12450	COG5002	protein histidine kinase activity
E3Z27_RS12450	COG0784	Response regulator, receiver
E3Z27_RS12470	COG4214	carbohydrate transport
E3Z27_RS12475	COG1129	ABC transporter
E3Z27_RS12480	COG4213	ABC transporter substrate-binding protein
E3Z27_RS12485	COG2115	Belongs to the xylose isomerase family
E3Z27_RS12490	COG1609	Transcriptional regulator
E3Z27_RS12490	COG2207	Transcriptional regulator
E3Z27_RS12495	COG4680	protein conserved in bacteria
E3Z27_RS12500	COG5499	transcription regulator containing HTH domain
E3Z27_RS12525	COG0443	Heat shock 70 kDa protein
E3Z27_RS12545	COG0765	amino acid transport
E3Z27_RS12550	COG0765	amino acid transport
E3Z27_RS12555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z27_RS12570	COG3938	Belongs to the proline racemase family
E3Z27_RS12575	COG1802	Transcriptional regulator
E3Z27_RS12580	COG1802	Transcriptional regulator
E3Z27_RS12600	COG3706	GGDEF domain
E3Z27_RS12615	COG0154	amidase activity
E3Z27_RS12620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3Z27_RS12655	COG3920	Histidine kinase
E3Z27_RS12655	COG2202	Pas domain
E3Z27_RS12695	COG0596	Alpha beta hydrolase
E3Z27_RS12705	COG2384	SAM-dependent methyltransferase
E3Z27_RS12740	COG4566	intracellular signal transduction
E3Z27_RS12755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3Z27_RS12760	COG1309	transcriptional regulator
E3Z27_RS12780	COG1538	Outer membrane efflux protein
E3Z27_RS12790	COG2706	6-phosphogluconolactonase activity
E3Z27_RS12805	COG0420	3'-5' exonuclease activity
E3Z27_RS12835	COG0714	Associated with various cellular activities
E3Z27_RS12850	COG2271	Major facilitator Superfamily
E3Z27_RS12855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z27_RS12865	COG1609	Transcriptional regulator
E3Z27_RS12895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS12930	COG2879	small protein
E3Z27_RS12935	COG0840	transmembrane signaling receptor activity
E3Z27_RS12940	COG4774	siderophore transport
E3Z27_RS12945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3Z27_RS12955	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3Z27_RS12965	COG3842	ATPase activity
E3Z27_RS12975	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z27_RS12985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3Z27_RS13000	COG2186	Transcriptional regulator
E3Z27_RS13005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS13010	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS13020	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS13025	COG2267	carboxylic ester hydrolase activity
E3Z27_RS13040	COG3321	synthase
E3Z27_RS13040	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS13040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z27_RS13040	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z27_RS13040	COG0300	oxidoreductase activity
E3Z27_RS13055	COG2308	Evidence 4 Homologs of previously reported genes of
E3Z27_RS13065	COG1305	Transglutaminase-like
E3Z27_RS13075	COG1794	racemase activity, acting on amino acids and derivatives
E3Z27_RS13105	COG1538	Outer membrane efflux protein
E3Z27_RS13110	COG1024	Enoyl-CoA hydratase
E3Z27_RS13115	COG2816	NAD+ diphosphatase activity
E3Z27_RS13190	COG0330	HflC and HflK could
E3Z27_RS13205	COG1522	sequence-specific DNA binding
E3Z27_RS13215	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS13240	COG3568	Endonuclease Exonuclease Phosphatase
E3Z27_RS13265	COG1640	4-alpha-glucanotransferase
E3Z27_RS13270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3Z27_RS13275	COG0297	glycogen (starch) synthase activity
E3Z27_RS13280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3Z27_RS13360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3Z27_RS13380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3Z27_RS13385	COG0456	acetyltransferase
E3Z27_RS13390	COG2194	sulfuric ester hydrolase activity
E3Z27_RS13395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E3Z27_RS13400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3Z27_RS13410	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3Z27_RS13470	COG0840	transmembrane signaling receptor activity
E3Z27_RS13490	COG0583	DNA-binding transcription factor activity
E3Z27_RS13495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3Z27_RS13510	COG0488	(ABC) transporter
E3Z27_RS13525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E3Z27_RS13535	COG2133	pyrroloquinoline quinone binding
E3Z27_RS13540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3Z27_RS13555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z27_RS13560	COG1070	Carbohydrate kinase
E3Z27_RS13565	COG0246	Mannitol dehydrogenase
E3Z27_RS13580	COG1175	transmembrane transport
E3Z27_RS13610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3Z27_RS13620	COG0784	Response regulator, receiver
E3Z27_RS13620	COG2205	protein histidine kinase activity
E3Z27_RS13620	COG5002	protein histidine kinase activity
E3Z27_RS13685	COG3795	YCII-related domain
E3Z27_RS13705	COG3842	ATPase activity
E3Z27_RS13720	COG1653	transport
E3Z27_RS13730	COG1132	(ABC) transporter
E3Z27_RS13745	COG0583	DNA-binding transcription factor activity
E3Z27_RS13750	COG0477	Major facilitator Superfamily
E3Z27_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS13785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS13795	COG0210	DNA helicase
E3Z27_RS13845	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E3Z27_RS13845	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E3Z27_RS13865	COG4191	Histidine kinase
E3Z27_RS13865	COG0784	Response regulator, receiver
E3Z27_RS13895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E3Z27_RS13910	COG1058	Belongs to the CinA family
E3Z27_RS13910	COG1546	Belongs to the CinA family
E3Z27_RS13920	COG2323	membrane
E3Z27_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS13935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3Z27_RS13950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3Z27_RS13965	COG3706	GGDEF domain
E3Z27_RS13970	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS13985	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS13990	COG1024	Enoyl-CoA hydratase
E3Z27_RS14005	COG0583	DNA-binding transcription factor activity
E3Z27_RS14015	COG4336	lyase activity
E3Z27_RS14040	COG1309	transcriptional regulator
E3Z27_RS14075	COG0840	transmembrane signaling receptor activity
E3Z27_RS14095	COG0604	alcohol dehydrogenase
E3Z27_RS14110	COG1301	dicarboxylic acid transport
E3Z27_RS14115	COG0252	asparaginase activity
E3Z27_RS14120	COG0251	oxidation-reduction process
E3Z27_RS14130	COG0583	DNA-binding transcription factor activity
E3Z27_RS14140	COG1522	sequence-specific DNA binding
E3Z27_RS14210	COG1301	dicarboxylic acid transport
E3Z27_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS14230	COG3386	PFAM SMP-30 Gluconolaconase
E3Z27_RS14240	COG0596	Alpha beta hydrolase
E3Z27_RS14310	COG2197	response regulator
E3Z27_RS14360	COG3501	Rhs element vgr protein
E3Z27_RS14390	COG2851	Citrate transporter
E3Z27_RS14395	COG1301	dicarboxylic acid transport
E3Z27_RS14400	COG2828	Protein conserved in bacteria
E3Z27_RS14405	COG0583	DNA-binding transcription factor activity
E3Z27_RS14410	COG3038	cytochrome b561
E3Z27_RS14450	COG1230	cation diffusion facilitator family transporter
E3Z27_RS14465	COG0583	DNA-binding transcription factor activity
E3Z27_RS14475	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E3Z27_RS14515	COG2271	Major facilitator Superfamily
E3Z27_RS14570	COG2207	Transcriptional regulator
E3Z27_RS14575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS14585	COG3038	cytochrome b561
E3Z27_RS14630	COG1121	(ABC) transporter
E3Z27_RS14635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3Z27_RS14675	COG0579	oxidoreductase
E3Z27_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS14690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3Z27_RS14695	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS14700	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS14710	COG2814	Major facilitator Superfamily
E3Z27_RS14720	COG3835	regulator
E3Z27_RS14735	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS14755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS14765	COG2207	Transcriptional regulator
E3Z27_RS14770	COG3971	2-oxopent-4-enoate hydratase activity
E3Z27_RS14805	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS14810	COG0028	Belongs to the TPP enzyme family
E3Z27_RS14825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3Z27_RS14840	COG0840	transmembrane signaling receptor activity
E3Z27_RS14845	COG0583	DNA-binding transcription factor activity
E3Z27_RS14855	COG1349	DNA-binding transcription factor activity
E3Z27_RS14865	COG1024	Enoyl-CoA hydratase
E3Z27_RS14870	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS14875	COG0183	Belongs to the thiolase family
E3Z27_RS14885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3Z27_RS14890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3Z27_RS14900	COG0463	Glycosyl transferase, family 2
E3Z27_RS14910	COG2207	Transcriptional regulator
E3Z27_RS14915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3Z27_RS14940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E3Z27_RS14950	COG4264	IucA IucC family
E3Z27_RS14965	COG2814	Major facilitator Superfamily
E3Z27_RS14970	COG0019	diaminopimelate decarboxylase activity
E3Z27_RS14975	COG4264	IucA IucC family
E3Z27_RS14980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS14985	COG4774	siderophore transport
E3Z27_RS14995	COG1595	DNA-templated transcription, initiation
E3Z27_RS15015	COG2205	protein histidine kinase activity
E3Z27_RS15015	COG0784	Response regulator, receiver
E3Z27_RS15025	COG0517	IMP dehydrogenase activity
E3Z27_RS15030	COG2146	nitrite reductase [NAD(P)H] activity
E3Z27_RS15030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3Z27_RS15035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3Z27_RS15035	COG2146	nitrite reductase [NAD(P)H] activity
E3Z27_RS15050	COG0116	Belongs to the methyltransferase superfamily
E3Z27_RS15050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3Z27_RS15060	COG1280	lysine exporter protein (LysE YggA)
E3Z27_RS15070	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E3Z27_RS15100	COG1024	Enoyl-CoA hydratase
E3Z27_RS15115	COG2814	Major facilitator Superfamily
E3Z27_RS15135	COG1959	2 iron, 2 sulfur cluster binding
E3Z27_RS15140	COG0579	oxidoreductase
E3Z27_RS15145	COG2205	protein histidine kinase activity
E3Z27_RS15160	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS15185	COG4993	Dehydrogenase
E3Z27_RS15185	COG2010	Cytochrome c
E3Z27_RS15225	COG1131	(ABC) transporter
E3Z27_RS15245	COG0784	Response regulator, receiver
E3Z27_RS15245	COG2205	protein histidine kinase activity
E3Z27_RS15260	COG4948	Mandelate Racemase Muconate Lactonizing
E3Z27_RS15270	COG0583	DNA-binding transcription factor activity
E3Z27_RS15285	COG1942	4-Oxalocrotonate Tautomerase
E3Z27_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS15305	COG2814	Major facilitator Superfamily
E3Z27_RS15310	COG1802	Transcriptional regulator
E3Z27_RS15325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS15340	COG2207	Transcriptional regulator
E3Z27_RS15340	COG0662	Cupin 2, conserved barrel domain protein
E3Z27_RS15355	COG0765	amino acid transport
E3Z27_RS15360	COG0765	amino acid transport
E3Z27_RS15365	COG1126	abc transporter atp-binding protein
E3Z27_RS15375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3Z27_RS15395	COG0022	dehydrogenase e1 component
E3Z27_RS15405	COG3199	ATP-NAD kinase
E3Z27_RS15410	COG3284	Transcriptional regulator
E3Z27_RS15430	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS15435	COG2205	protein histidine kinase activity
E3Z27_RS15440	COG0028	Belongs to the TPP enzyme family
E3Z27_RS15445	COG5001	Diguanylate cyclase
E3Z27_RS15470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z27_RS15480	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS15485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3Z27_RS15525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3Z27_RS15585	COG4566	intracellular signal transduction
E3Z27_RS15590	COG4566	intracellular signal transduction
E3Z27_RS15600	COG0583	DNA-binding transcription factor activity
E3Z27_RS15620	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS15640	COG2072	flavoprotein involved in K transport
E3Z27_RS15650	COG2203	Gaf domain
E3Z27_RS15650	COG4251	negative regulation of phosphorylation
E3Z27_RS15650	COG5001	Diguanylate cyclase
E3Z27_RS15650	COG3706	GGDEF domain
E3Z27_RS15655	COG0826	peptidase U32
E3Z27_RS15705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3Z27_RS15705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3Z27_RS15720	COG2181	nitrate reductase activity
E3Z27_RS15725	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3Z27_RS15730	COG1140	nitrate reductase beta subunit
E3Z27_RS15735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3Z27_RS15740	COG2223	nitrite transmembrane transporter activity
E3Z27_RS15750	COG3850	Histidine kinase
E3Z27_RS15755	COG2197	response regulator
E3Z27_RS15790	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3Z27_RS15800	COG3604	Transcriptional regulator
E3Z27_RS15820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z27_RS15835	COG3256	nitric oxide reductase
E3Z27_RS15840	COG2010	Cytochrome c
E3Z27_RS15870	COG2010	Cytochrome c
E3Z27_RS15875	COG3391	amine dehydrogenase activity
E3Z27_RS15900	COG0535	radical SAM domain protein
E3Z27_RS15905	COG1648	precorrin-2 dehydrogenase activity
E3Z27_RS15905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3Z27_RS15965	COG1136	(ABC) transporter
E3Z27_RS15965	COG0577	efflux transmembrane transporter activity
E3Z27_RS16020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z27_RS16040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS16045	COG2207	Transcriptional regulator
E3Z27_RS16060	COG0454	-acetyltransferase
E3Z27_RS16070	COG0583	DNA-binding transcription factor activity
E3Z27_RS16125	COG1819	glycosyl
E3Z27_RS16130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3Z27_RS16150	COG1538	Outer membrane efflux protein
E3Z27_RS16200	COG1609	Transcriptional regulator
E3Z27_RS16220	COG0308	aminopeptidase N
E3Z27_RS16230	COG3139	Protein of unknown function (DUF1315)
E3Z27_RS16240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3Z27_RS16245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3Z27_RS16260	COG0640	Transcriptional regulator
E3Z27_RS16280	COG0431	NADPH-dependent FMN reductase
E3Z27_RS16300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z27_RS16305	COG0328	RNA-DNA hybrid ribonuclease activity
E3Z27_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3Z27_RS16320	COG1388	LysM domain
E3Z27_RS16320	COG0741	lytic transglycosylase activity
E3Z27_RS16325	COG4166	transmembrane transport
E3Z27_RS16330	COG4166	transmembrane transport
E3Z27_RS16335	COG4174	ABC transporter (Permease)
E3Z27_RS16340	COG4239	(ABC) transporter, permease
E3Z27_RS16345	COG4172	Belongs to the ABC transporter superfamily
E3Z27_RS16355	COG2199	diguanylate cyclase activity
E3Z27_RS16355	COG2203	Gaf domain
E3Z27_RS16360	COG2207	Transcriptional regulator
E3Z27_RS16370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3Z27_RS16380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3Z27_RS16380	COG2169	Transcriptional regulator
E3Z27_RS16390	COG3791	Glutathione-dependent formaldehyde-activating
E3Z27_RS16400	COG0589	response to stress
E3Z27_RS16415	COG0814	amino acid
E3Z27_RS16420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3Z27_RS16490	COG3501	Rhs element vgr protein
E3Z27_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS16515	COG0673	inositol 2-dehydrogenase activity
E3Z27_RS16535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3Z27_RS16535	COG2111	Na H antiporter
E3Z27_RS16540	COG1006	Multisubunit Na H antiporter MnhC subunit
E3Z27_RS16555	COG2212	antiporter activity
E3Z27_RS16560	COG1320	monovalent cation:proton antiporter activity
E3Z27_RS16595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3Z27_RS16600	COG4211	Belongs to the binding-protein-dependent transport system permease family
E3Z27_RS16605	COG1129	ABC transporter
E3Z27_RS16615	COG0673	inositol 2-dehydrogenase activity
E3Z27_RS16620	COG0673	inositol 2-dehydrogenase activity
E3Z27_RS16625	COG3962	Belongs to the TPP enzyme family
E3Z27_RS16635	COG3718	enzyme involved in inositol metabolism
E3Z27_RS16655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS16660	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3Z27_RS16665	COG3383	formate dehydrogenase (NAD+) activity
E3Z27_RS16670	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS16675	COG5002	protein histidine kinase activity
E3Z27_RS16695	COG1953	Uracil, thiamine, allantoin
E3Z27_RS16715	COG1309	transcriptional regulator
E3Z27_RS16725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3Z27_RS16765	COG1522	sequence-specific DNA binding
E3Z27_RS16770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3Z27_RS16775	COG0022	dehydrogenase e1 component
E3Z27_RS16785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3Z27_RS16790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS16825	COG1335	isochorismatase
E3Z27_RS16835	COG2205	protein histidine kinase activity
E3Z27_RS16840	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS16875	COG3468	outer membrane autotransporter barrel domain protein
E3Z27_RS16900	COG1929	Belongs to the glycerate kinase type-1 family
E3Z27_RS16905	COG3835	regulator
E3Z27_RS16910	COG2271	Major facilitator Superfamily
E3Z27_RS16915	COG0667	Aldo Keto reductase
E3Z27_RS16930	COG0697	spore germination
E3Z27_RS16935	COG0583	DNA-binding transcription factor activity
E3Z27_RS16955	COG3634	alkyl hydroperoxide reductase activity
E3Z27_RS16960	COG0450	alkyl hydroperoxide reductase
E3Z27_RS17000	COG3145	DNA-N1-methyladenine dioxygenase activity
E3Z27_RS17005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3Z27_RS17005	COG2169	Transcriptional regulator
E3Z27_RS17030	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E3Z27_RS17060	COG1611	Belongs to the LOG family
E3Z27_RS17065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z27_RS17070	COG0534	Mate efflux family protein
E3Z27_RS17080	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS17090	COG0643	Histidine kinase
E3Z27_RS17090	COG2198	Histidine kinase
E3Z27_RS17095	COG0840	transmembrane signaling receptor activity
E3Z27_RS17100	COG0835	chemotaxis
E3Z27_RS17110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E3Z27_RS17115	COG2201	protein-glutamate methylesterase activity
E3Z27_RS17120	COG4176	ABC-type proline glycine betaine transport system permease component
E3Z27_RS17125	COG1116	anion transmembrane transporter activity
E3Z27_RS17130	COG4191	Histidine kinase
E3Z27_RS17135	COG4566	intracellular signal transduction
E3Z27_RS17165	COG0583	DNA-binding transcription factor activity
E3Z27_RS17170	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS17205	COG0789	Transcriptional regulator
E3Z27_RS17210	COG0784	Response regulator, receiver
E3Z27_RS17210	COG4191	Histidine kinase
E3Z27_RS17220	COG4221	oxidoreductase activity
E3Z27_RS17235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3Z27_RS17265	COG2223	nitrite transmembrane transporter activity
E3Z27_RS17295	COG1522	sequence-specific DNA binding
E3Z27_RS17305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3Z27_RS17310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3Z27_RS17315	COG0454	-acetyltransferase
E3Z27_RS17325	COG0473	3-isopropylmalate dehydrogenase activity
E3Z27_RS17340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS17360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3Z27_RS17365	COG0601	transmembrane transport
E3Z27_RS17370	COG0747	negative chemotaxis
E3Z27_RS17375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS17410	COG0251	oxidation-reduction process
E3Z27_RS17435	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS17440	COG2205	protein histidine kinase activity
E3Z27_RS17465	COG0667	Aldo Keto reductase
E3Z27_RS17470	COG0583	DNA-binding transcription factor activity
E3Z27_RS17500	COG1620	l-lactate permease
E3Z27_RS17515	COG2211	Major facilitator Superfamily
E3Z27_RS17525	COG0673	inositol 2-dehydrogenase activity
E3Z27_RS17530	COG1609	Transcriptional regulator
E3Z27_RS17580	COG1335	isochorismatase
E3Z27_RS17615	COG2168	tRNA wobble position uridine thiolation
E3Z27_RS17620	COG2920	part of a sulfur-relay system
E3Z27_RS17625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3Z27_RS17630	COG0435	Glutathione S-transferase
E3Z27_RS17635	COG1648	precorrin-2 dehydrogenase activity
E3Z27_RS17635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3Z27_RS17645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3Z27_RS17650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3Z27_RS17655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3Z27_RS17660	COG1674	ftsk spoiiie
E3Z27_RS17665	COG0492	ferredoxin-NADP+ reductase activity
E3Z27_RS17670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3Z27_RS17675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E3Z27_RS17680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3Z27_RS17685	COG0542	response to heat
E3Z27_RS17690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3Z27_RS17695	COG1278	Cold shock
E3Z27_RS17715	COG0482	sulfurtransferase activity
E3Z27_RS17720	COG2915	High frequency lysogenization protein hflD homolog
E3Z27_RS17730	COG2850	peptidyl-arginine hydroxylation
E3Z27_RS17735	COG2153	protein acetylation
E3Z27_RS17745	COG2224	Isocitrate lyase
E3Z27_RS17750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z27_RS17755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z27_RS17760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z27_RS17760	COG0649	NAD binding
E3Z27_RS17775	COG1034	ATP synthesis coupled electron transport
E3Z27_RS17780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E3Z27_RS17785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3Z27_RS17795	COG0713	ATP synthesis coupled electron transport
E3Z27_RS17820	COG1349	DNA-binding transcription factor activity
E3Z27_RS17825	COG3622	Belongs to the hyi family
E3Z27_RS17830	COG2610	gluconate transmembrane transporter activity
E3Z27_RS17835	COG0235	Class ii aldolase
E3Z27_RS17840	COG3395	kinase activity
E3Z27_RS17845	COG2084	Dehydrogenase
E3Z27_RS17850	COG0579	oxidoreductase
E3Z27_RS17860	COG0583	DNA-binding transcription factor activity
E3Z27_RS17865	COG1335	isochorismatase
E3Z27_RS17910	COG1741	Belongs to the pirin family
E3Z27_RS17930	COG0840	transmembrane signaling receptor activity
E3Z27_RS17940	COG2113	Glycine betaine
E3Z27_RS17945	COG1902	pentaerythritol trinitrate reductase activity
E3Z27_RS17945	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3Z27_RS17950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3Z27_RS17980	COG1196	nuclear chromosome segregation
E3Z27_RS17995	COG0776	regulation of translation
E3Z27_RS18000	COG0072	phenylalanine-tRNA ligase activity
E3Z27_RS18005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3Z27_RS18010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3Z27_RS18015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3Z27_RS18020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3Z27_RS18025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3Z27_RS18035	COG1278	Cold shock
E3Z27_RS18060	COG1869	D-ribose catabolic process
E3Z27_RS18065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3Z27_RS18070	COG1609	Transcriptional regulator
E3Z27_RS18075	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z27_RS18080	COG1129	ABC transporter
E3Z27_RS18085	COG1879	ABC-type sugar transport system periplasmic component
E3Z27_RS18105	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3Z27_RS18115	COG0215	cysteine-tRNA ligase activity
E3Z27_RS18120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3Z27_RS18130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3Z27_RS18140	COG1566	PFAM secretion protein HlyD family protein
E3Z27_RS18150	COG1846	Transcriptional regulator
E3Z27_RS18160	COG0729	surface antigen
E3Z27_RS18170	COG0708	Exodeoxyribonuclease III
E3Z27_RS18175	COG2885	chlorophyll binding
E3Z27_RS18195	COG5383	Protein conserved in bacteria
E3Z27_RS18225	COG1136	(ABC) transporter
E3Z27_RS18320	COG3394	polysaccharide catabolic process
E3Z27_RS18340	COG0395	ABC-type sugar transport system, permease component
E3Z27_RS18350	COG3842	ATPase activity
E3Z27_RS18355	COG3842	ATPase activity
E3Z27_RS18360	COG3284	Transcriptional regulator
E3Z27_RS18390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3Z27_RS18420	COG0583	DNA-binding transcription factor activity
E3Z27_RS18425	COG1598	PFAM Uncharacterised protein family UPF0150
E3Z27_RS18635	COG0305	Participates in initiation and elongation during chromosome replication
E3Z27_RS18640	COG1484	DNA-dependent DNA replication
E3Z27_RS18675	COG4197	protein conserved in bacteria, prophage-related
E3Z27_RS18795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS18810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS18815	COG1017	nitric oxide dioxygenase activity
E3Z27_RS18815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z27_RS18850	COG1286	toxin biosynthetic process
E3Z27_RS18855	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3Z27_RS18860	COG0285	dihydrofolate synthase activity
E3Z27_RS18865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3Z27_RS18870	COG0135	phosphoribosylanthranilate isomerase activity
E3Z27_RS18895	COG0473	3-isopropylmalate dehydrogenase activity
E3Z27_RS18900	COG2226	methyltransferase
E3Z27_RS18905	COG0066	3-isopropylmalate dehydratase activity
E3Z27_RS18910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3Z27_RS18930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3Z27_RS18940	COG2267	carboxylic ester hydrolase activity
E3Z27_RS18975	COG0556	nucleotide-excision repair
E3Z27_RS19015	COG2056	Na+-H+ antiporter family
E3Z27_RS19025	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS19045	COG0720	synthase
E3Z27_RS19060	COG0402	S-adenosylhomocysteine deaminase activity
E3Z27_RS19065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3Z27_RS19070	COG2223	nitrite transmembrane transporter activity
E3Z27_RS19080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS19110	COG2205	protein histidine kinase activity
E3Z27_RS19110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS19120	COG4106	trans-aconitate 2-methyltransferase activity
E3Z27_RS19125	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS19130	COG3387	PFAM Glycoside hydrolase 15-related
E3Z27_RS19140	COG2267	carboxylic ester hydrolase activity
E3Z27_RS19155	COG4221	oxidoreductase activity
E3Z27_RS19160	COG2207	Transcriptional regulator
E3Z27_RS19170	COG3755	Protein conserved in bacteria
E3Z27_RS19200	COG5006	permease, DMT superfamily
E3Z27_RS19255	COG0372	Belongs to the citrate synthase family
E3Z27_RS19265	COG1802	Transcriptional regulator
E3Z27_RS19270	COG0189	ligase activity
E3Z27_RS19270	COG4067	protein conserved in archaea
E3Z27_RS19280	COG0189	ligase activity
E3Z27_RS19290	COG0560	Phosphoserine phosphatase
E3Z27_RS19300	COG1953	Uracil, thiamine, allantoin
E3Z27_RS19310	COG0583	DNA-binding transcription factor activity
E3Z27_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS19320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3Z27_RS19360	COG0697	spore germination
E3Z27_RS19380	COG0583	DNA-binding transcription factor activity
E3Z27_RS19385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3Z27_RS19390	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS19400	COG2271	Major facilitator Superfamily
E3Z27_RS19405	COG2169	Transcriptional regulator
E3Z27_RS19445	COG0204	Acyl-transferase
E3Z27_RS19450	COG0598	Magnesium transport protein CorA
E3Z27_RS19455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3Z27_RS19455	COG0519	Catalyzes the synthesis of GMP from XMP
E3Z27_RS19460	COG1024	Enoyl-CoA hydratase
E3Z27_RS19460	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3Z27_RS19465	COG0183	Belongs to the thiolase family
E3Z27_RS19475	COG1305	Transglutaminase-like
E3Z27_RS19510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS19515	COG3047	cAMP biosynthetic process
E3Z27_RS19515	COG2885	chlorophyll binding
E3Z27_RS19550	COG1064	alcohol dehydrogenase
E3Z27_RS19555	COG1414	Transcriptional regulator
E3Z27_RS19560	COG2271	Major facilitator Superfamily
E3Z27_RS19565	COG4948	Mandelate Racemase Muconate Lactonizing
E3Z27_RS19570	COG0800	Aldolase
E3Z27_RS19575	COG3734	2-keto-3-deoxy-galactonokinase
E3Z27_RS19600	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3Z27_RS19605	COG1129	ABC transporter
E3Z27_RS19610	COG1879	ABC-type sugar transport system periplasmic component
E3Z27_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS19625	COG2186	Transcriptional regulator
E3Z27_RS19650	COG0084	hydrolase, TatD family'
E3Z27_RS19665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3Z27_RS19670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3Z27_RS19680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3Z27_RS19685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3Z27_RS19700	COG0416	fatty acid biosynthetic process
E3Z27_RS19705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3Z27_RS19710	COG1399	metal-binding, possibly nucleic acid-binding protein
E3Z27_RS19715	COG0424	maF-like protein
E3Z27_RS19720	COG0616	signal peptide processing
E3Z27_RS19720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3Z27_RS19725	COG0546	phosphoglycolate phosphatase activity
E3Z27_RS19735	COG1530	ribonuclease E activity
E3Z27_RS19745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3Z27_RS19745	COG3608	succinylglutamate desuccinylase aspartoacylase
E3Z27_RS19760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3Z27_RS19765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3Z27_RS19775	COG2835	tetraacyldisaccharide 4'-kinase activity
E3Z27_RS19780	COG1663	tetraacyldisaccharide 4'-kinase activity
E3Z27_RS19785	COG0848	biopolymer transport protein
E3Z27_RS19805	COG0842	Transport permease protein
E3Z27_RS19810	COG1131	(ABC) transporter
E3Z27_RS19815	COG0625	glutathione transferase activity
E3Z27_RS19840	COG4964	Belongs to the GSP D family
E3Z27_RS19910	COG1522	sequence-specific DNA binding
E3Z27_RS19945	COG0840	transmembrane signaling receptor activity
E3Z27_RS19950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS19955	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS19960	COG2130	NADP-dependent
E3Z27_RS19965	COG0284	orotidine-5'-phosphate decarboxylase activity
E3Z27_RS19975	COG2205	protein histidine kinase activity
E3Z27_RS19985	COG0628	permease
E3Z27_RS20020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3Z27_RS20025	COG4771	TonB-dependent receptor
E3Z27_RS20035	COG5002	protein histidine kinase activity
E3Z27_RS20035	COG2205	protein histidine kinase activity
E3Z27_RS20035	COG0784	Response regulator, receiver
E3Z27_RS20040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3Z27_RS20055	COG1741	Belongs to the pirin family
E3Z27_RS20065	COG0326	Molecular chaperone. Has ATPase activity
E3Z27_RS20100	COG0045	succinate-CoA ligase (ADP-forming) activity
E3Z27_RS20105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3Z27_RS20120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3Z27_RS20125	COG1053	succinate dehydrogenase
E3Z27_RS20130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3Z27_RS20135	COG2009	succinate dehydrogenase
E3Z27_RS20145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3Z27_RS20150	COG3162	membrane
E3Z27_RS20155	COG2113	Glycine betaine
E3Z27_RS20165	COG2853	Lipoprotein
E3Z27_RS20170	COG2354	Protein conserved in bacteria
E3Z27_RS20175	COG1309	transcriptional regulator
E3Z27_RS20195	COG3622	Belongs to the hyi family
E3Z27_RS20200	COG2084	Dehydrogenase
E3Z27_RS20210	COG0469	pyruvate kinase activity
E3Z27_RS20220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3Z27_RS20225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3Z27_RS20230	COG2814	Major facilitator Superfamily
E3Z27_RS20260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
E3Z27_RS20265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E3Z27_RS20270	COG0235	Class ii aldolase
E3Z27_RS20280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3Z27_RS20285	COG1073	alpha beta
E3Z27_RS20310	COG2840	Smr protein MutS2
E3Z27_RS20320	COG1673	EVE domain
E3Z27_RS20330	COG0302	gtp cyclohydrolase
E3Z27_RS20340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS20350	COG2252	PERMEase
E3Z27_RS20395	COG4266	Belongs to the allantoicase family
E3Z27_RS20400	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E3Z27_RS20420	COG1560	Kdo2-lipid A biosynthetic process
E3Z27_RS20425	COG0850	regulation of cytokinetic process
E3Z27_RS20430	COG2894	cell division
E3Z27_RS20435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3Z27_RS20440	COG0564	pseudouridine synthase activity
E3Z27_RS20445	COG1362	aminopeptidase activity
E3Z27_RS20470	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z27_RS20515	COG2200	EAL domain
E3Z27_RS20530	COG3209	COG3209 Rhs family protein
E3Z27_RS20550	COG0545	Peptidyl-prolyl cis-trans isomerase
E3Z27_RS20555	COG2010	Cytochrome c
E3Z27_RS20590	COG1741	Belongs to the pirin family
E3Z27_RS20595	COG0583	DNA-binding transcription factor activity
E3Z27_RS20600	COG0583	DNA-binding transcription factor activity
E3Z27_RS20640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z27_RS20645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3Z27_RS20660	COG3088	subunit of a heme lyase
E3Z27_RS20670	COG1138	Cytochrome C-type biogenesis protein
E3Z27_RS20675	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E3Z27_RS20690	COG1335	isochorismatase
E3Z27_RS20695	COG2309	aminopeptidase activity
E3Z27_RS20700	COG0596	Alpha beta hydrolase
E3Z27_RS20705	COG3473	Maleate cis-trans isomerase
E3Z27_RS20715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z27_RS20720	COG0840	transmembrane signaling receptor activity
E3Z27_RS20725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3Z27_RS20765	COG0477	Major facilitator Superfamily
E3Z27_RS20795	COG3474	cytochrome
E3Z27_RS20825	COG0579	oxidoreductase
E3Z27_RS20900	COG2003	Belongs to the UPF0758 family
E3Z27_RS21065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3Z27_RS21065	COG0515	serine threonine protein kinase
E3Z27_RS21105	COG0582	viral genome integration into host DNA
E3Z27_RS21120	COG2974	May be involved in recombination
E3Z27_RS21125	COG0385	Bile acid
E3Z27_RS21130	COG2076	Multidrug Resistance protein
E3Z27_RS21160	COG2205	protein histidine kinase activity
E3Z27_RS21160	COG2202	Pas domain
E3Z27_RS21205	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E3Z27_RS21210	COG0406	alpha-ribazole phosphatase activity
E3Z27_RS21215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E3Z27_RS21225	COG1492	cobalamin metabolic process
E3Z27_RS21240	COG0778	Nitroreductase
E3Z27_RS21245	COG1797	cobyrinic acid a,c-diamide synthase activity
E3Z27_RS21270	COG0791	NLP P60 protein
E3Z27_RS21275	COG0791	NLP P60 protein
E3Z27_RS21280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3Z27_RS21285	COG0628	permease
E3Z27_RS21295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3Z27_RS21300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3Z27_RS21320	COG3956	TIGRFAM MazG family protein
E3Z27_RS21325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3Z27_RS21330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3Z27_RS21395	COG5002	protein histidine kinase activity
E3Z27_RS21395	COG0784	Response regulator, receiver
E3Z27_RS21395	COG2205	protein histidine kinase activity
E3Z27_RS21400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3Z27_RS21435	COG2818	Glycosylase
E3Z27_RS21440	COG0037	tRNA processing
E3Z27_RS21450	COG3091	SprT-like family
E3Z27_RS21455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3Z27_RS21465	COG4977	sequence-specific DNA binding
E3Z27_RS21465	COG1917	Cupin 2, conserved barrel domain protein
E3Z27_RS21475	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS21495	COG2205	protein histidine kinase activity
E3Z27_RS21500	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS21510	COG1749	Flagellar hook protein flgE
E3Z27_RS21515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3Z27_RS21520	COG1558	bacterial-type flagellum-dependent cell motility
E3Z27_RS21525	COG1815	bacterial-type flagellum-dependent cell motility
E3Z27_RS21530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3Z27_RS21535	COG0835	chemotaxis
E3Z27_RS21535	COG0784	Response regulator, receiver
E3Z27_RS21545	COG2747	anti-sigma28 factor FlgM
E3Z27_RS21555	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E3Z27_RS21560	COG0477	Major facilitator Superfamily
E3Z27_RS21570	COG5002	protein histidine kinase activity
E3Z27_RS21580	COG0583	DNA-binding transcription factor activity
E3Z27_RS21585	COG0156	8-amino-7-oxononanoate synthase activity
E3Z27_RS21595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3Z27_RS21600	COG2259	Doxx family
E3Z27_RS21605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3Z27_RS21610	COG0163	prenyltransferase activity
E3Z27_RS21620	COG0583	DNA-binding transcription factor activity
E3Z27_RS21650	COG2239	Acts as a magnesium transporter
E3Z27_RS21675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3Z27_RS21680	COG0527	aspartate kinase activity
E3Z27_RS21685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3Z27_RS21690	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E3Z27_RS21695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3Z27_RS21700	COG2988	succinylglutamate desuccinylase activity
E3Z27_RS21710	COG3724	N-succinylarginine dihydrolase activity
E3Z27_RS21730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3Z27_RS21750	COG4215	(ABC) transporter
E3Z27_RS21760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3Z27_RS21770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3Z27_RS21815	COG0504	CTP synthase activity
E3Z27_RS21820	COG2329	Antibiotic biosynthesis monooxygenase
E3Z27_RS21830	COG0584	glycerophosphoryl diester phosphodiesterase
E3Z27_RS21860	COG1113	amino acid transport
E3Z27_RS21875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3Z27_RS21885	COG0009	L-threonylcarbamoyladenylate synthase
E3Z27_RS21890	COG0613	PHP domain protein
E3Z27_RS21895	COG2917	probably involved in intracellular septation
E3Z27_RS21900	COG2350	Protein conserved in bacteria
E3Z27_RS21910	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS21920	COG0642	Histidine kinase
E3Z27_RS21940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS21950	COG3642	lipopolysaccharide core region biosynthetic process
E3Z27_RS21975	COG0459	protein refolding
E3Z27_RS21995	COG1028	Short-chain dehydrogenase reductase Sdr
E3Z27_RS22000	COG0489	protein tyrosine kinase activity
E3Z27_RS22005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3Z27_RS22005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3Z27_RS22010	COG4657	Part of a membrane complex involved in electron transport
E3Z27_RS22015	COG2878	Part of a membrane complex involved in electron transport
E3Z27_RS22020	COG4658	electron transport chain
E3Z27_RS22025	COG4659	FMN binding
E3Z27_RS22035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3Z27_RS22045	COG2197	response regulator
E3Z27_RS22055	COG0137	argininosuccinate synthase activity
E3Z27_RS22065	COG0418	dihydroorotase activity
E3Z27_RS22070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z27_RS22075	COG0450	alkyl hydroperoxide reductase
E3Z27_RS22080	COG2906	2 iron, 2 sulfur cluster binding
E3Z27_RS22090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3Z27_RS22095	COG0243	molybdopterin cofactor binding
E3Z27_RS22105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3Z27_RS22110	COG3842	ATPase activity
E3Z27_RS22120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3Z27_RS22145	COG0765	amino acid transport
E3Z27_RS22150	COG0765	amino acid transport
E3Z27_RS22155	COG1126	abc transporter atp-binding protein
E3Z27_RS22175	COG2910	NAD(P)H-binding
E3Z27_RS22195	COG0509	glycine decarboxylation via glycine cleavage system
E3Z27_RS22200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3Z27_RS22200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3Z27_RS22205	COG1760	l-serine dehydratase
E3Z27_RS22215	COG1278	Cold shock
E3Z27_RS22225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3Z27_RS22230	COG2132	Multicopper oxidase
E3Z27_RS22250	COG2807	transmembrane transport
E3Z27_RS22265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3Z27_RS22305	COG0602	queuosine metabolic process
E3Z27_RS22310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E3Z27_RS22315	COG2885	chlorophyll binding
E3Z27_RS22320	COG0823	Involved in the tonB-independent uptake of proteins
E3Z27_RS22340	COG0824	Thioesterase
E3Z27_RS22345	COG2255	four-way junction helicase activity
E3Z27_RS22350	COG0632	four-way junction helicase activity
E3Z27_RS22355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3Z27_RS22360	COG0217	transcriptional regulatory protein
E3Z27_RS22365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3Z27_RS22380	COG0783	Belongs to the Dps family
E3Z27_RS22390	COG2900	Belongs to the SlyX family
E3Z27_RS22405	COG0668	transmembrane transport
E3Z27_RS22410	COG1666	GTP binding
E3Z27_RS22425	COG2096	Adenosyltransferase
E3Z27_RS22430	COG0494	nUDIX hydrolase
E3Z27_RS22440	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3Z27_RS22455	COG0433	COG0433 Predicted ATPase
E3Z27_RS22465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3Z27_RS22465	COG0438	transferase activity, transferring glycosyl groups
E3Z27_RS22490	COG2925	Exonuclease
E3Z27_RS22515	COG0714	Associated with various cellular activities
E3Z27_RS22580	COG3706	GGDEF domain
E3Z27_RS22605	COG4191	Histidine kinase
E3Z27_RS22615	COG0477	Major facilitator Superfamily
E3Z27_RS22645	COG2207	Transcriptional regulator
E3Z27_RS22655	COG0583	DNA-binding transcription factor activity
E3Z27_RS22660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3Z27_RS22665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3Z27_RS22670	COG0583	DNA-binding transcription factor activity
E3Z27_RS22675	COG1247	-acetyltransferase
E3Z27_RS22680	COG1280	lysine exporter protein (LysE YggA)
E3Z27_RS22685	COG0494	nUDIX hydrolase
E3Z27_RS22705	COG1858	cytochrome C peroxidase
E3Z27_RS22710	COG3852	Histidine kinase
E3Z27_RS22720	COG0069	glutamate synthase activity
E3Z27_RS22725	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E3Z27_RS22735	COG1113	amino acid transport
E3Z27_RS22785	COG1695	Transcriptional regulator
E3Z27_RS22790	COG2375	cellular response to nickel ion
E3Z27_RS22800	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E3Z27_RS22810	COG4628	conserved protein (DUF2132)
E3Z27_RS22830	COG0494	nUDIX hydrolase
E3Z27_RS22860	COG2188	Transcriptional regulator
E3Z27_RS22865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3Z27_RS22870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3Z27_RS22875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3Z27_RS22875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3Z27_RS22880	COG1263	PTS System
E3Z27_RS22880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3Z27_RS22880	COG2190	(PTS) system
E3Z27_RS22895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3Z27_RS22895	COG0047	phosphoribosylformylglycinamidine synthase activity
E3Z27_RS22900	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E3Z27_RS22905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3Z27_RS22910	COG1381	Involved in DNA repair and RecF pathway recombination
E3Z27_RS22915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3Z27_RS22920	COG0571	ribonuclease III activity
E3Z27_RS22925	COG0681	Belongs to the peptidase S26 family
E3Z27_RS22930	COG0481	GTPase activity
E3Z27_RS22940	COG0795	lipopolysaccharide-transporting ATPase activity
E3Z27_RS22945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3Z27_RS22960	COG0525	valine-tRNA ligase activity
E3Z27_RS22975	COG3081	Nucleoid-associated protein
E3Z27_RS22990	COG2827	Endonuclease containing a URI domain
E3Z27_RS23000	COG2807	transmembrane transport
E3Z27_RS23005	COG2186	Transcriptional regulator
E3Z27_RS23020	COG1126	abc transporter atp-binding protein
E3Z27_RS23030	COG4597	amino acid ABC transporter
E3Z27_RS23035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS23040	COG0400	carboxylic ester hydrolase activity
E3Z27_RS23045	COG0513	Belongs to the DEAD box helicase family
E3Z27_RS23080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3Z27_RS23085	COG0315	cyclic pyranopterin monophosphate synthase activity
E3Z27_RS23090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E3Z27_RS23100	COG0726	polysaccharide deacetylase
E3Z27_RS23105	COG3022	response to hydroperoxide
E3Z27_RS23115	COG1215	transferase activity, transferring glycosyl groups
E3Z27_RS23120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3Z27_RS23125	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E3Z27_RS23135	COG3420	alginic acid biosynthetic process
E3Z27_RS23150	COG1696	Membrane protein involved in D-alanine export
E3Z27_RS23165	COG0662	Cupin 2, conserved barrel domain protein
E3Z27_RS23165	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3Z27_RS23185	COG0300	oxidoreductase activity
E3Z27_RS23190	COG1566	PFAM secretion protein HlyD family protein
E3Z27_RS23210	COG0583	DNA-binding transcription factor activity
E3Z27_RS23235	COG5002	protein histidine kinase activity
E3Z27_RS23240	COG5001	Diguanylate cyclase
E3Z27_RS23240	COG4251	negative regulation of phosphorylation
E3Z27_RS23240	COG3706	GGDEF domain
E3Z27_RS23240	COG2203	Gaf domain
E3Z27_RS23245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E3Z27_RS23250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3Z27_RS23265	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3Z27_RS23270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3Z27_RS23275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3Z27_RS23280	COG0772	Belongs to the SEDS family
E3Z27_RS23285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3Z27_RS23290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3Z27_RS23295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3Z27_RS23300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3Z27_RS23315	COG0275	rRNA processing
E3Z27_RS23320	COG2001	Belongs to the MraZ family
E3Z27_RS23335	COG3107	peptidoglycan biosynthetic process
E3Z27_RS23340	COG0792	nuclease activity
E3Z27_RS23345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3Z27_RS23350	COG2823	Periplasmic or secreted lipoprotein
E3Z27_RS23360	COG2969	positive regulation of protein catabolic process
E3Z27_RS23365	COG0625	glutathione transferase activity
E3Z27_RS23370	COG2857	Cytochrome c1
E3Z27_RS23375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3Z27_RS23380	COG0723	plastoquinol--plastocyanin reductase activity
E3Z27_RS23385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3Z27_RS23390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3Z27_RS23395	COG0667	Aldo Keto reductase
E3Z27_RS23400	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS23410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E3Z27_RS23415	COG0180	Tryptophanyl-tRNA synthetase
E3Z27_RS23430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3Z27_RS23450	COG0318	PFAM AMP-dependent synthetase and ligase
E3Z27_RS23460	COG1280	lysine exporter protein (LysE YggA)
E3Z27_RS23465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3Z27_RS23470	COG2813	Specifically methylates the guanine in position
E3Z27_RS23475	COG2119	membrane
E3Z27_RS23480	COG0501	Belongs to the peptidase M48B family
E3Z27_RS23485	COG0840	transmembrane signaling receptor activity
E3Z27_RS23490	COG2135	peptidase activity
E3Z27_RS23545	COG0659	secondary active sulfate transmembrane transporter activity
E3Z27_RS23560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E3Z27_RS23570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3Z27_RS23575	COG1090	epimerase
E3Z27_RS23580	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E3Z27_RS23590	COG0789	Transcriptional regulator
E3Z27_RS23615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3Z27_RS23620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3Z27_RS23630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3Z27_RS23635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3Z27_RS23645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E3Z27_RS23650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3Z27_RS23660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3Z27_RS23665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3Z27_RS23670	COG0193	aminoacyl-tRNA hydrolase activity
E3Z27_RS23695	COG1280	lysine exporter protein (LysE YggA)
E3Z27_RS23700	COG0583	DNA-binding transcription factor activity
E3Z27_RS23705	COG1253	flavin adenine dinucleotide binding
E3Z27_RS23710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3Z27_RS23735	COG0405	Gamma-glutamyltransferase
E3Z27_RS23740	COG3655	Transcriptional regulator
E3Z27_RS23755	COG2031	fatty acid transporter
E3Z27_RS23770	COG0288	reversible hydration of carbon dioxide
E3Z27_RS23780	COG0456	acetyltransferase
E3Z27_RS23805	COG3008	intermembrane lipid transfer
E3Z27_RS23810	COG2995	paraquat-inducible protein a
E3Z27_RS23815	COG2995	paraquat-inducible protein a
E3Z27_RS23845	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E3Z27_RS23850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3Z27_RS23855	COG1183	phosphatidylcholine synthase activity
E3Z27_RS23860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3Z27_RS23870	COG0028	Belongs to the TPP enzyme family
E3Z27_RS23890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3Z27_RS23920	COG1489	DNA binding
E3Z27_RS23930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3Z27_RS23935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3Z27_RS23945	COG4191	Histidine kinase
E3Z27_RS23965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E3Z27_RS23970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3Z27_RS23980	COG0166	Belongs to the GPI family
E3Z27_RS23985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3Z27_RS23990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3Z27_RS24005	COG2823	Periplasmic or secreted lipoprotein
E3Z27_RS24025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3Z27_RS24030	COG0237	dephospho-CoA kinase activity
E3Z27_RS24035	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3Z27_RS24060	COG1252	NADH dehydrogenase
E3Z27_RS24090	COG0542	response to heat
E3Z27_RS24125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS24165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3Z27_RS24170	COG1047	Peptidyl-prolyl cis-trans
E3Z27_RS24175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3Z27_RS24180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3Z27_RS24185	COG0196	riboflavin kinase activity
E3Z27_RS24195	COG0268	Binds directly to 16S ribosomal RNA
E3Z27_RS24200	COG3045	CreA protein
E3Z27_RS24205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3Z27_RS24210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3Z27_RS24215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3Z27_RS24220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3Z27_RS24225	COG0142	geranyltranstransferase activity
E3Z27_RS24230	COG2824	Alkylphosphonate utilization operon protein PhnA
E3Z27_RS24240	COG0545	Peptidyl-prolyl cis-trans isomerase
E3Z27_RS24245	COG2862	Uncharacterized protein family, UPF0114
E3Z27_RS24255	COG1067	ATP-dependent peptidase activity
E3Z27_RS24275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z27_RS24280	COG0488	(ABC) transporter
E3Z27_RS24290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3Z27_RS24315	COG0523	cobalamin synthesis protein
E3Z27_RS24320	COG2879	small protein
E3Z27_RS24350	COG1970	mechanosensitive ion channel activity
E3Z27_RS24360	COG2197	response regulator
E3Z27_RS24365	COG2813	Specifically methylates the guanine in position
E3Z27_RS24375	COG1294	oxidase, subunit
E3Z27_RS24380	COG1271	oxidase subunit
E3Z27_RS24390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3Z27_RS24395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E3Z27_RS24400	COG2080	2 iron, 2 sulfur cluster binding
E3Z27_RS24415	COG0693	protein deglycase activity
E3Z27_RS24425	COG2252	PERMEase
E3Z27_RS24430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3Z27_RS24435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3Z27_RS24440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3Z27_RS24445	COG1309	transcriptional regulator
E3Z27_RS24470	COG2321	neutral zinc metallopeptidase
E3Z27_RS24485	COG1946	Acyl-CoA thioesterase
E3Z27_RS24495	COG0123	including yeast histone deacetylase and acetoin utilization protein
E3Z27_RS24505	COG0513	Belongs to the DEAD box helicase family
E3Z27_RS24510	COG0697	spore germination
E3Z27_RS24515	COG1522	sequence-specific DNA binding
E3Z27_RS24520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3Z27_RS24520	COG1199	ATP-dependent helicase activity
E3Z27_RS24530	COG3416	Protein conserved in bacteria
E3Z27_RS24545	COG1643	Atp-dependent helicase
E3Z27_RS24555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3Z27_RS24565	COG1522	sequence-specific DNA binding
E3Z27_RS24580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E3Z27_RS24585	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS24595	COG0351	phosphomethylpyrimidine kinase
E3Z27_RS24600	COG0352	thiamine-phosphate diphosphorylase activity
E3Z27_RS24605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3Z27_RS24620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3Z27_RS24625	COG1702	phosphate starvation-inducible protein PhoH
E3Z27_RS24630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3Z27_RS24635	COG4535	Mg2 and Co2 transporter CorC
E3Z27_RS24640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3Z27_RS24655	COG0495	leucyl-tRNA aminoacylation
E3Z27_RS24675	COG2951	lytic endotransglycosylase activity
E3Z27_RS24680	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3Z27_RS24685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3Z27_RS24690	COG0321	lipoyl(octanoyl) transferase activity
E3Z27_RS24695	COG2921	Belongs to the UPF0250 family
E3Z27_RS24700	COG1686	Belongs to the peptidase S11 family
E3Z27_RS24710	COG2951	lytic endotransglycosylase activity
E3Z27_RS24715	COG0772	Belongs to the SEDS family
E3Z27_RS24720	COG0768	penicillin binding
E3Z27_RS24725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3Z27_RS24740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3Z27_RS24745	COG2094	Belongs to the DNA glycosylase MPG family
E3Z27_RS24750	COG0586	Pfam SNARE associated Golgi protein
E3Z27_RS24760	COG1346	cytolysis
E3Z27_RS24780	COG0702	epimerase
E3Z27_RS24795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3Z27_RS24800	COG3284	Transcriptional regulator
E3Z27_RS24805	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS24815	COG4303	Ethanolamine ammonia lyase large subunit
E3Z27_RS24820	COG4302	ethanolamine ammonia-lyase activity
E3Z27_RS24825	COG0456	acetyltransferase
E3Z27_RS24830	COG0586	Pfam SNARE associated Golgi protein
E3Z27_RS24835	COG3228	Belongs to the MtfA family
E3Z27_RS24840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3Z27_RS24870	COG2433	Pfam Transposase IS66
E3Z27_RS24930	COG3177	Filamentation induced by cAMP protein fic
E3Z27_RS24950	COG0604	alcohol dehydrogenase
E3Z27_RS24950	COG3321	synthase
E3Z27_RS24975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3Z27_RS24980	COG2267	carboxylic ester hydrolase activity
E3Z27_RS24985	COG0671	phosphoesterase, PA-phosphatase related
E3Z27_RS24985	COG2453	phosphatase
E3Z27_RS25000	COG4589	Belongs to the CDS family
E3Z27_RS25010	COG3077	Addiction module antitoxin, RelB DinJ family
E3Z27_RS25015	COG2026	Addiction module toxin, RelE StbE family
E3Z27_RS25020	COG4676	Protein conserved in bacteria
E3Z27_RS25025	COG5445	Predicted secreted protein (DUF2300)
E3Z27_RS25040	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E3Z27_RS25045	COG4676	Protein conserved in bacteria
E3Z27_RS25050	COG1722	exodeoxyribonuclease VII activity
E3Z27_RS25055	COG0142	geranyltranstransferase activity
E3Z27_RS25060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3Z27_RS25070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3Z27_RS25080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3Z27_RS25090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3Z27_RS25095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3Z27_RS25110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3Z27_RS25110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3Z27_RS25115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3Z27_RS25125	COG2264	protein methyltransferase activity
E3Z27_RS25130	COG3118	belongs to the thioredoxin family
E3Z27_RS25145	COG1136	(ABC) transporter
E3Z27_RS25160	COG3047	cAMP biosynthetic process
E3Z27_RS25165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3Z27_RS25175	COG1201	RNA secondary structure unwinding
E3Z27_RS25180	COG0668	transmembrane transport
E3Z27_RS25190	COG3568	Endonuclease Exonuclease Phosphatase
E3Z27_RS25200	COG0392	lysyltransferase activity
E3Z27_RS25220	COG1335	isochorismatase
E3Z27_RS25225	COG0629	single-stranded DNA binding
E3Z27_RS25230	COG2814	Major facilitator Superfamily
E3Z27_RS25235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3Z27_RS25240	COG2193	ferroxidase activity
E3Z27_RS25250	COG0203	ribosomal protein L17
E3Z27_RS25260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3Z27_RS25265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3Z27_RS25270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3Z27_RS25275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3Z27_RS25285	COG0200	Binds to the 23S rRNA
E3Z27_RS25290	COG1841	ribosomal large subunit assembly
E3Z27_RS25295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3Z27_RS25300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3Z27_RS25305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3Z27_RS25310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3Z27_RS25315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3Z27_RS25325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3Z27_RS25330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3Z27_RS25335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3Z27_RS25340	COG0255	Belongs to the universal ribosomal protein uL29 family
E3Z27_RS25345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3Z27_RS25350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3Z27_RS25360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3Z27_RS25365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3Z27_RS25370	COG0089	rRNA binding
E3Z27_RS25375	COG0088	Forms part of the polypeptide exit tunnel
E3Z27_RS25385	COG0051	transcription antitermination factor activity, RNA binding
E3Z27_RS25390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3Z27_RS25395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3Z27_RS25400	COG0049	tRNA binding
E3Z27_RS25405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3Z27_RS25410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3Z27_RS25415	COG0085	RNA polymerase activity
E3Z27_RS25420	COG0222	ribosome binding
E3Z27_RS25425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3Z27_RS25430	COG0081	regulation of translation
E3Z27_RS25435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3Z27_RS25455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3Z27_RS25480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E3Z27_RS25515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3Z27_RS25525	COG0739	heme binding
E3Z27_RS25530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E3Z27_RS25535	COG0316	Belongs to the HesB IscA family
E3Z27_RS25540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3Z27_RS25565	COG0537	adenosine 5'-monophosphoramidase activity
E3Z27_RS25570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E3Z27_RS25575	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E3Z27_RS25580	COG1765	OsmC-like protein
E3Z27_RS25595	COG0134	indole-3-glycerol-phosphate synthase activity
E3Z27_RS25600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3Z27_RS25605	COG0512	Glutamine amidotransferase of anthranilate synthase
E3Z27_RS25615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3Z27_RS25620	COG0546	phosphoglycolate phosphatase activity
E3Z27_RS25625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3Z27_RS25630	COG1454	alcohol dehydrogenase
E3Z27_RS25640	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z27_RS25650	COG3842	ATPase activity
E3Z27_RS25655	COG2197	response regulator
E3Z27_RS25660	COG4585	Histidine kinase
E3Z27_RS25670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3Z27_RS25675	COG3178	'Phosphotransferase
E3Z27_RS25685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3Z27_RS25690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3Z27_RS25695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3Z27_RS25700	COG2967	ApaG domain
E3Z27_RS25705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3Z27_RS25710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3Z27_RS25715	COG2766	serine protein kinase
E3Z27_RS25720	COG2718	Belongs to the UPF0229 family
E3Z27_RS25725	COG2719	SpoVR family
E3Z27_RS25730	COG0617	tRNA 3'-terminal CCA addition
E3Z27_RS25735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3Z27_RS25740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3Z27_RS25745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E3Z27_RS25750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3Z27_RS25755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3Z27_RS25760	COG0358	DNA primase activity
E3Z27_RS25765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3Z27_RS25780	COG3550	peptidyl-serine autophosphorylation
E3Z27_RS25805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3Z27_RS25810	COG1025	Belongs to the peptidase M16 family
E3Z27_RS25820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3Z27_RS25825	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E3Z27_RS25835	COG0535	radical SAM domain protein
E3Z27_RS25850	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS25855	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS25860	COG3706	GGDEF domain
E3Z27_RS25865	COG1960	acyl-CoA dehydrogenase activity
E3Z27_RS25885	COG2226	methyltransferase
E3Z27_RS25885	COG1073	alpha beta
E3Z27_RS25890	COG0156	8-amino-7-oxononanoate synthase activity
E3Z27_RS25895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3Z27_RS25905	COG3585	molybdate ion transport
E3Z27_RS25905	COG2005	Transcriptional regulator
E3Z27_RS25915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3Z27_RS25930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E3Z27_RS25935	COG2204	response regulator
E3Z27_RS25950	COG1595	DNA-templated transcription, initiation
E3Z27_RS25955	COG3712	iron ion homeostasis
E3Z27_RS25960	COG4774	siderophore transport
E3Z27_RS25970	COG2271	Major facilitator Superfamily
E3Z27_RS25975	COG0625	glutathione transferase activity
E3Z27_RS25980	COG4452	Inner membrane protein CreD
E3Z27_RS25985	COG2205	protein histidine kinase activity
E3Z27_RS25990	COG0745	RESPONSE REGULATOR receiver
E3Z27_RS25995	COG0189	ligase activity
E3Z27_RS25995	COG4067	protein conserved in archaea
E3Z27_RS26000	COG0204	Acyl-transferase
E3Z27_RS26020	COG1063	alcohol dehydrogenase
E3Z27_RS26045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3Z27_RS26060	COG1943	Transposase
E3Z27_RS26065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3Z27_RS26065	COG1017	nitric oxide dioxygenase activity
E3Z27_RS26070	COG4638	Rieske (2fe-2S)
E3Z27_RS26080	COG1858	cytochrome C peroxidase
E3Z27_RS26100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3Z27_RS26105	COG2181	nitrate reductase activity
E3Z27_RS26105	COG0247	lactate metabolic process
E3Z27_RS26110	COG1902	pentaerythritol trinitrate reductase activity
E3Z27_RS26110	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3Z27_RS26155	COG3246	L-lysine catabolic process to acetate
E3Z27_RS26160	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3Z27_RS26190	COG1760	l-serine dehydratase
E3Z27_RS26200	COG4176	ABC-type proline glycine betaine transport system permease component
E3Z27_RS26205	COG4175	Glycine betaine
E3Z27_RS26210	COG1309	transcriptional regulator
E3Z27_RS26215	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS26220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E3Z27_RS26230	COG0312	modulator of DNA gyrase
E3Z27_RS26235	COG0477	Major facilitator Superfamily
E3Z27_RS26240	COG0513	Belongs to the DEAD box helicase family
E3Z27_RS26245	COG2081	HI0933 family
E3Z27_RS26250	COG1289	transmembrane transporter activity
E3Z27_RS26270	COG1451	nucleotide metabolic process
E3Z27_RS26315	COG0126	phosphoglycerate kinase activity
E3Z27_RS26320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3Z27_RS26330	COG0640	Transcriptional regulator
E3Z27_RS26375	COG2814	Major facilitator Superfamily
E3Z27_RS26380	COG2116	formate transmembrane transporter activity
E3Z27_RS26390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3Z27_RS26395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3Z27_RS26405	COG0513	Belongs to the DEAD box helicase family
E3Z27_RS26410	COG2353	YceI-like domain
E3Z27_RS26415	COG3038	cytochrome b561
E3Z27_RS26435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3Z27_RS26440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS26455	COG1272	protein, Hemolysin III
E3Z27_RS26475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3Z27_RS26495	COG3052	prosthetic group binding
E3Z27_RS26500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E3Z27_RS26550	COG0189	ligase activity
E3Z27_RS26560	COG1678	Uncharacterized ACR, COG1678
E3Z27_RS26565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3Z27_RS26570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E3Z27_RS26580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3Z27_RS26590	COG0791	NLP P60 protein
E3Z27_RS26615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3Z27_RS26620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E3Z27_RS26620	COG2813	Specifically methylates the guanine in position
E3Z27_RS26630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3Z27_RS26635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3Z27_RS26645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3Z27_RS26650	COG2022	thiamine diphosphate biosynthetic process
E3Z27_RS26660	COG2363	Small membrane protein
E3Z27_RS26665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3Z27_RS26675	COG2177	Part of the ABC transporter FtsEX involved in
E3Z27_RS26680	COG2884	Cell division ATP-binding protein ftsE
E3Z27_RS26685	COG0552	protein localization to endoplasmic reticulum
E3Z27_RS26690	COG0612	Peptidase, M16
E3Z27_RS26695	COG0612	Peptidase, M16
E3Z27_RS26700	COG0742	ribosomal rna small subunit methyltransferase
E3Z27_RS26705	COG0429	hydrolase of the alpha beta-hydrolase fold
E3Z27_RS26730	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E3Z27_RS26735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3Z27_RS26740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3Z27_RS26750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3Z27_RS26760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3Z27_RS26775	COG2814	Major facilitator Superfamily
E3Z27_RS26780	COG0129	dihydroxy-acid dehydratase activity
E3Z27_RS26805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3Z27_RS26840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3Z27_RS26855	COG1177	transmembrane transport
E3Z27_RS26860	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3Z27_RS26865	COG3842	ATPase activity
E3Z27_RS26885	COG0174	glutamine synthetase
E3Z27_RS26890	COG0174	glutamine synthetase
E3Z27_RS26905	COG1116	anion transmembrane transporter activity
E3Z27_RS26910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3Z27_RS26915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3Z27_RS26920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3Z27_RS26925	COG0431	NADPH-dependent FMN reductase
E3Z27_RS26930	COG0450	alkyl hydroperoxide reductase
E3Z27_RS26950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3Z27_RS26960	COG1522	sequence-specific DNA binding
E3Z27_RS26980	COG0509	glycine decarboxylation via glycine cleavage system
E3Z27_RS26985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3Z27_RS26990	COG1178	ABC-type Fe3 transport system permease component
E3Z27_RS27000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z27_RS27005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3Z27_RS27010	COG0006	proline dipeptidase activity
E3Z27_RS27015	COG3079	Belongs to the UPF0149 family
E3Z27_RS27035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3Z27_RS27055	COG2271	Major facilitator Superfamily
E3Z27_RS27070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3Z27_RS27090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS27095	COG0765	amino acid transport
E3Z27_RS27105	COG1126	abc transporter atp-binding protein
E3Z27_RS27110	COG0248	Ppx GppA phosphatase
E3Z27_RS27115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3Z27_RS27125	COG0586	Pfam SNARE associated Golgi protein
E3Z27_RS27135	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E3Z27_RS27140	COG1671	Belongs to the UPF0178 family
E3Z27_RS27145	COG0672	)-iron permease
E3Z27_RS27185	COG3501	Rhs element vgr protein
E3Z27_RS27190	COG1280	lysine exporter protein (LysE YggA)
E3Z27_RS27200	COG0488	(ABC) transporter
E3Z27_RS27225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3Z27_RS27240	COG0181	hydroxymethylbilane synthase activity
E3Z27_RS27250	COG0165	Argininosuccinate lyase
E3Z27_RS27255	COG0625	glutathione transferase activity
E3Z27_RS27270	COG3072	Adenylate cyclase
E3Z27_RS27275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3Z27_RS27285	COG1965	Belongs to the frataxin family
E3Z27_RS27295	COG0019	diaminopimelate decarboxylase activity
E3Z27_RS27300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3Z27_RS27310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E3Z27_RS27315	COG1011	Hydrolase
E3Z27_RS27325	COG0432	Pfam Uncharacterised protein family UPF0047
E3Z27_RS27330	COG0004	ammonium transporteR
E3Z27_RS27335	COG0347	Belongs to the P(II) protein family
E3Z27_RS27355	COG0606	chelatase, subunit chli
E3Z27_RS27365	COG0840	transmembrane signaling receptor activity
E3Z27_RS27370	COG0583	DNA-binding transcription factor activity
E3Z27_RS27390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3Z27_RS27395	COG0427	acetyl-CoA hydrolase
E3Z27_RS27410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3Z27_RS27415	COG0251	oxidation-reduction process
E3Z27_RS27420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS27425	COG1522	sequence-specific DNA binding
E3Z27_RS27435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3Z27_RS27445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3Z27_RS27460	COG1012	belongs to the aldehyde dehydrogenase family
E3Z27_RS27470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3Z27_RS27475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3Z27_RS27480	COG0747	negative chemotaxis
E3Z27_RS27485	COG2003	Belongs to the UPF0758 family
E3Z27_RS27490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3Z27_RS27495	COG0756	dUTP diphosphatase activity
E3Z27_RS27500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3Z27_RS27505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3Z27_RS27510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3Z27_RS27515	COG0708	Exodeoxyribonuclease III
E3Z27_RS27525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3Z27_RS27530	COG1561	YicC-like family, N-terminal region
E3Z27_RS27535	COG0194	GDP metabolic process
E3Z27_RS27540	COG1758	RNA polymerase activity
E3Z27_RS27545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3Z27_RS27640	COG0631	protein serine/threonine phosphatase activity
E3Z27_RS27645	COG0515	serine threonine protein kinase
E3Z27_RS27645	COG2815	serine threonine protein kinase
E3Z27_RS27660	COG0848	biopolymer transport protein
E3Z27_RS27670	COG0583	DNA-binding transcription factor activity
E3Z27_RS27675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3Z27_RS27730	COG2815	serine threonine protein kinase
E3Z27_RS27730	COG0515	serine threonine protein kinase
E3Z27_RS27820	COG3501	Rhs element vgr protein
E3Z27_RS27830	COG3209	COG3209 Rhs family protein
E3Z27_RS27885	COG3161	chorismate lyase activity
E3Z27_RS27890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3Z27_RS27915	COG0739	heme binding
E3Z27_RS27930	COG0704	Plays a role in the regulation of phosphate uptake
E3Z27_RS27935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3Z27_RS27940	COG0573	inorganic phosphate transmembrane transporter activity
E3Z27_RS27955	COG0477	Major facilitator Superfamily
E3Z27_RS27960	COG1607	acyl-coa hydrolase
E3Z27_RS27990	COG0583	DNA-binding transcription factor activity
E3Z27_RS27995	COG1027	Aspartate ammonia-lyase
E3Z27_RS28000	COG1115	amino acid carrier protein
E3Z27_RS28005	COG0252	asparaginase activity
E3Z27_RS28070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3Z27_RS28075	COG0765	amino acid transport
E3Z27_RS28085	COG0511	ligase activity, forming carbon-carbon bonds
E3Z27_RS28085	COG5016	pyruvate
E3Z27_RS28090	COG0439	Biotin carboxylase
E3Z27_RS28095	COG0583	DNA-binding transcription factor activity
E3Z27_RS28115	COG0210	DNA helicase
E3Z27_RS28130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3Z27_RS28130	COG4651	solute:proton antiporter activity
E3Z27_RS28135	COG1607	acyl-coa hydrolase
E3Z27_RS28140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3Z27_RS28150	COG0523	cobalamin synthesis protein
E3Z27_RS28175	COG1469	GTP cyclohydrolase I activity
E3Z27_RS28185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3Z27_RS28190	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3Z27_RS28200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3Z27_RS28205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3Z27_RS28210	COG2217	Heavy metal translocating P-type atpase
E3Z27_RS28240	COG0625	glutathione transferase activity
E3Z27_RS28245	COG0583	DNA-binding transcription factor activity
E3Z27_RS28260	COG0494	nUDIX hydrolase
E3Z27_RS28265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E3Z27_RS28275	COG1335	isochorismatase
E3Z27_RS28280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3Z27_RS28295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3Z27_RS28300	COG1349	DNA-binding transcription factor activity
E3Z27_RS28305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3Z27_RS28310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3Z27_RS28315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3Z27_RS28320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3Z27_RS28325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3Z27_RS28330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3Z27_RS28335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3Z27_RS28345	COG0356	it plays a direct role in the translocation of protons across the membrane
E3Z27_RS28350	COG3312	ion transport
E3Z27_RS28355	COG1475	DNA binding
E3Z27_RS28360	COG1192	Involved in chromosome partitioning
E3Z27_RS28365	COG0357	Ribosomal RNA small subunit methyltransferase G
E3Z27_RS28370	COG0445	tRNA wobble uridine modification
E3Z27_RS28375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3Z27_RS28380	COG0706	membrane insertase activity
E3Z27_RS28385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3Z27_RS28390	COG0594	ribonuclease P activity
E3Z27_RS28395	COG0230	Belongs to the bacterial ribosomal protein bL34 family