locus-tag	class	description
C4Q27_RS00040	COG0277	FAD linked oxidase domain protein
C4Q27_RS00045	COG0247	lactate metabolic process
C4Q27_RS00050	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4Q27_RS00065	COG2807	transmembrane transport
C4Q27_RS00070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4Q27_RS00085	COG0183	Belongs to the thiolase family
C4Q27_RS00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4Q27_RS00100	COG0784	Response regulator, receiver
C4Q27_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS00100	COG2198	Histidine kinase
C4Q27_RS00100	COG2205	protein histidine kinase activity
C4Q27_RS00115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4Q27_RS00155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4Q27_RS00200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS00205	COG2826	transposase and inactivated derivatives, IS30 family
C4Q27_RS00215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4Q27_RS00215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4Q27_RS00235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS00240	COG0456	acetyltransferase
C4Q27_RS00240	COG1846	Transcriptional regulator
C4Q27_RS00270	COG1686	Belongs to the peptidase S11 family
C4Q27_RS00315	COG1121	(ABC) transporter
C4Q27_RS00370	COG0583	DNA-binding transcription factor activity
C4Q27_RS00385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4Q27_RS00395	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4Q27_RS00400	COG1177	transmembrane transport
C4Q27_RS00405	COG3842	ATPase activity
C4Q27_RS00425	COG3258	Cytochrome c
C4Q27_RS00430	COG2863	cytochrome
C4Q27_RS00460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4Q27_RS00470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4Q27_RS00475	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS00480	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C4Q27_RS00485	COG0784	Response regulator, receiver
C4Q27_RS00485	COG4191	Histidine kinase
C4Q27_RS00500	COG2259	Doxx family
C4Q27_RS00510	COG1064	alcohol dehydrogenase
C4Q27_RS00530	COG1090	epimerase
C4Q27_RS00555	COG0840	transmembrane signaling receptor activity
C4Q27_RS00560	COG2814	Major facilitator Superfamily
C4Q27_RS00565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS00570	COG1846	Transcriptional regulator
C4Q27_RS00590	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS00595	COG3384	dioxygenase
C4Q27_RS00605	COG2271	Major facilitator Superfamily
C4Q27_RS00610	COG3971	2-oxopent-4-enoate hydratase activity
C4Q27_RS00620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4Q27_RS00625	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS00635	COG1846	Transcriptional regulator
C4Q27_RS00645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS00665	COG0531	amino acid
C4Q27_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS00685	COG3344	reverse transcriptase
C4Q27_RS00705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS00845	COG2856	Zn peptidase
C4Q27_RS00965	COG1724	mRNA binding
C4Q27_RS00970	COG1598	PFAM Uncharacterised protein family UPF0150
C4Q27_RS01020	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4Q27_RS01020	COG1674	ftsk spoiiie
C4Q27_RS01165	COG0616	signal peptide processing
C4Q27_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS01190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4Q27_RS01215	COG0490	domain, Protein
C4Q27_RS01215	COG0471	metal ion transport
C4Q27_RS01220	COG2199	diguanylate cyclase activity
C4Q27_RS01255	COG2271	Major facilitator Superfamily
C4Q27_RS01260	COG1335	isochorismatase
C4Q27_RS01265	COG3473	Maleate cis-trans isomerase
C4Q27_RS01270	COG0596	Alpha beta hydrolase
C4Q27_RS01275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4Q27_RS01280	COG2309	aminopeptidase activity
C4Q27_RS01285	COG1846	Transcriptional regulator
C4Q27_RS01310	COG2080	2 iron, 2 sulfur cluster binding
C4Q27_RS01315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4Q27_RS01315	COG2010	Cytochrome c
C4Q27_RS01320	COG1309	transcriptional regulator
C4Q27_RS01335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4Q27_RS01340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4Q27_RS01345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4Q27_RS01425	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS01430	COG0583	DNA-binding transcription factor activity
C4Q27_RS01435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4Q27_RS01440	COG0148	phosphopyruvate hydratase activity
C4Q27_RS01445	COG0469	pyruvate kinase activity
C4Q27_RS01450	COG0477	Major facilitator Superfamily
C4Q27_RS01460	COG1850	ribulose-bisphosphate carboxylase activity
C4Q27_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS01490	COG2233	PERMEase
C4Q27_RS01510	COG2920	part of a sulfur-relay system
C4Q27_RS01515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4Q27_RS01525	COG1648	precorrin-2 dehydrogenase activity
C4Q27_RS01525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4Q27_RS01530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4Q27_RS01535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4Q27_RS01540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4Q27_RS01545	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4Q27_RS01550	COG1674	ftsk spoiiie
C4Q27_RS01555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4Q27_RS01560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4Q27_RS01565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4Q27_RS01570	COG0542	response to heat
C4Q27_RS01575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4Q27_RS01580	COG1278	Cold shock
C4Q27_RS01600	COG0482	sulfurtransferase activity
C4Q27_RS01605	COG2915	High frequency lysogenization protein hflD homolog
C4Q27_RS01620	COG2850	peptidyl-arginine hydroxylation
C4Q27_RS01625	COG2153	protein acetylation
C4Q27_RS01630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4Q27_RS01635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS01660	COG2816	NAD+ diphosphatase activity
C4Q27_RS01665	COG1024	Enoyl-CoA hydratase
C4Q27_RS01670	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4Q27_RS01675	COG3040	lipid binding
C4Q27_RS01680	COG1234	tRNA 3'-trailer cleavage
C4Q27_RS01690	COG1953	Uracil, thiamine, allantoin
C4Q27_RS01700	COG0493	'glutamate synthase
C4Q27_RS01710	COG1309	transcriptional regulator
C4Q27_RS01720	COG3387	PFAM Glycoside hydrolase 15-related
C4Q27_RS01725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4Q27_RS01730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4Q27_RS01735	COG0297	glycogen (starch) synthase activity
C4Q27_RS01740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4Q27_RS01745	COG1640	4-alpha-glucanotransferase
C4Q27_RS01765	COG3568	Endonuclease Exonuclease Phosphatase
C4Q27_RS01780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4Q27_RS01785	COG0366	Alpha amylase catalytic
C4Q27_RS01795	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS01800	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS01805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4Q27_RS01820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4Q27_RS01970	COG0322	excinuclease ABC activity
C4Q27_RS01995	COG0306	phosphate transporter
C4Q27_RS02015	COG0625	glutathione transferase activity
C4Q27_RS02020	COG2050	protein possibly involved in aromatic compounds catabolism
C4Q27_RS02020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4Q27_RS02025	COG1113	amino acid transport
C4Q27_RS02030	COG0583	DNA-binding transcription factor activity
C4Q27_RS02035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4Q27_RS02050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4Q27_RS02055	COG0659	secondary active sulfate transmembrane transporter activity
C4Q27_RS02090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q27_RS02095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q27_RS02100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q27_RS02100	COG0649	NAD binding
C4Q27_RS02115	COG1034	ATP synthesis coupled electron transport
C4Q27_RS02120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4Q27_RS02125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4Q27_RS02135	COG0713	ATP synthesis coupled electron transport
C4Q27_RS02150	COG1007	ATP synthesis coupled electron transport
C4Q27_RS02185	COG0431	NADPH-dependent FMN reductase
C4Q27_RS02205	COG0328	RNA-DNA hybrid ribonuclease activity
C4Q27_RS02215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4Q27_RS02220	COG0741	lytic transglycosylase activity
C4Q27_RS02220	COG1388	LysM domain
C4Q27_RS02225	COG4166	transmembrane transport
C4Q27_RS02230	COG4166	transmembrane transport
C4Q27_RS02235	COG4174	ABC transporter (Permease)
C4Q27_RS02240	COG4239	(ABC) transporter, permease
C4Q27_RS02245	COG4172	Belongs to the ABC transporter superfamily
C4Q27_RS02250	COG3311	Transcriptional regulator
C4Q27_RS02255	COG1569	PIN domain
C4Q27_RS02260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4Q27_RS02270	COG0583	DNA-binding transcription factor activity
C4Q27_RS02275	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS02280	COG2205	protein histidine kinase activity
C4Q27_RS02285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4Q27_RS02295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4Q27_RS02305	COG0628	permease
C4Q27_RS02340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4Q27_RS02355	COG4999	Histidine kinase
C4Q27_RS02355	COG3850	Histidine kinase
C4Q27_RS02355	COG3437	response regulator, receiver
C4Q27_RS02355	COG2205	protein histidine kinase activity
C4Q27_RS02360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4Q27_RS02375	COG1741	Belongs to the pirin family
C4Q27_RS02385	COG0326	Molecular chaperone. Has ATPase activity
C4Q27_RS02420	COG0045	succinate-CoA ligase (ADP-forming) activity
C4Q27_RS02425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q27_RS02445	COG1053	succinate dehydrogenase
C4Q27_RS02450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4Q27_RS02455	COG2009	succinate dehydrogenase
C4Q27_RS02480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS02485	COG2885	chlorophyll binding
C4Q27_RS02515	COG2944	sequence-specific DNA binding
C4Q27_RS02525	COG0477	Major facilitator Superfamily
C4Q27_RS02540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS02545	COG1136	(ABC) transporter
C4Q27_RS02545	COG0577	efflux transmembrane transporter activity
C4Q27_RS02550	COG1538	Outer membrane efflux protein
C4Q27_RS02570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4Q27_RS02570	COG0515	serine threonine protein kinase
C4Q27_RS02590	COG0657	acetylesterase activity
C4Q27_RS02625	COG0642	Histidine kinase
C4Q27_RS02640	COG3608	succinylglutamate desuccinylase aspartoacylase
C4Q27_RS02640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4Q27_RS02675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4Q27_RS02715	COG3123	guanosine phosphorylase activity
C4Q27_RS02725	COG3278	Belongs to the heme-copper respiratory oxidase family
C4Q27_RS02740	COG2010	Cytochrome c
C4Q27_RS02760	COG3278	Belongs to the heme-copper respiratory oxidase family
C4Q27_RS02775	COG2010	Cytochrome c
C4Q27_RS02785	COG0348	domain, Protein
C4Q27_RS02795	COG2217	Heavy metal translocating P-type atpase
C4Q27_RS02815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4Q27_RS02820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4Q27_RS02825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4Q27_RS02835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4Q27_RS02840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4Q27_RS02875	COG0789	Transcriptional regulator
C4Q27_RS02885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4Q27_RS02890	COG3115	cell septum assembly
C4Q27_RS02920	COG0402	S-adenosylhomocysteine deaminase activity
C4Q27_RS02925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4Q27_RS02935	COG2252	PERMEase
C4Q27_RS02970	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4Q27_RS02980	COG2233	PERMEase
C4Q27_RS03000	COG2354	Protein conserved in bacteria
C4Q27_RS03020	COG0483	inositol monophosphate 1-phosphatase activity
C4Q27_RS03040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4Q27_RS03130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4Q27_RS03130	COG0758	DNA mediated transformation
C4Q27_RS03165	COG2323	membrane
C4Q27_RS03260	COG1063	alcohol dehydrogenase
C4Q27_RS03270	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS03280	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS03345	COG1546	Belongs to the CinA family
C4Q27_RS03345	COG1058	Belongs to the CinA family
C4Q27_RS03355	COG2323	membrane
C4Q27_RS03360	COG3387	PFAM Glycoside hydrolase 15-related
C4Q27_RS03385	COG2826	transposase and inactivated derivatives, IS30 family
C4Q27_RS03455	COG3960	tartronate-semialdehyde synthase activity
C4Q27_RS03460	COG3622	Belongs to the hyi family
C4Q27_RS03465	COG2084	Dehydrogenase
C4Q27_RS03475	COG0469	pyruvate kinase activity
C4Q27_RS03505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4Q27_RS03520	COG0116	Belongs to the methyltransferase superfamily
C4Q27_RS03520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4Q27_RS03530	COG1522	sequence-specific DNA binding
C4Q27_RS03535	COG1953	Uracil, thiamine, allantoin
C4Q27_RS03570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q27_RS03600	COG1138	Cytochrome C-type biogenesis protein
C4Q27_RS03605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4Q27_RS03625	COG4133	protoheme IX ABC transporter activity
C4Q27_RS03635	COG2257	FlhB HrpN YscU SpaS Family
C4Q27_RS03650	COG0835	chemotaxis
C4Q27_RS03660	COG1192	Involved in chromosome partitioning
C4Q27_RS03670	COG1360	Flagellar Motor Protein
C4Q27_RS03675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4Q27_RS03680	COG2201	protein-glutamate methylesterase activity
C4Q27_RS03685	COG0643	Histidine kinase
C4Q27_RS03685	COG0784	Response regulator, receiver
C4Q27_RS03685	COG2198	Histidine kinase
C4Q27_RS03690	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4Q27_RS03715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4Q27_RS03735	COG1987	bacterial-type flagellum assembly
C4Q27_RS03780	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS03790	COG2882	bacterial-type flagellum organization
C4Q27_RS03815	COG1677	Flagellar hook-basal body complex protein FliE
C4Q27_RS03850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4Q27_RS03870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4Q27_RS03885	COG1256	bacterial-type flagellum assembly
C4Q27_RS03885	COG4786	Flagellar basal body rod
C4Q27_RS03895	COG1706	bacterial-type flagellum-dependent cell motility
C4Q27_RS03900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C4Q27_RS03925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4Q27_RS03935	COG1815	bacterial-type flagellum-dependent cell motility
C4Q27_RS03945	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4Q27_RS03950	COG0835	chemotaxis
C4Q27_RS03950	COG0784	Response regulator, receiver
C4Q27_RS03970	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4Q27_RS03975	COG0477	Major facilitator Superfamily
C4Q27_RS03985	COG1522	sequence-specific DNA binding
C4Q27_RS03990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4Q27_RS03995	COG0022	dehydrogenase e1 component
C4Q27_RS04005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q27_RS04010	COG3706	GGDEF domain
C4Q27_RS04020	COG1113	amino acid transport
C4Q27_RS04045	COG2239	Acts as a magnesium transporter
C4Q27_RS04075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4Q27_RS04080	COG0527	aspartate kinase activity
C4Q27_RS04085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4Q27_RS04090	COG2988	succinylglutamate desuccinylase activity
C4Q27_RS04100	COG3724	N-succinylarginine dihydrolase activity
C4Q27_RS04105	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS04120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4Q27_RS04145	COG4215	(ABC) transporter
C4Q27_RS04150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS04155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4Q27_RS04180	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4Q27_RS04190	COG0277	FAD linked oxidase domain protein
C4Q27_RS04190	COG0247	lactate metabolic process
C4Q27_RS04205	COG1113	amino acid transport
C4Q27_RS04215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4Q27_RS04225	COG0009	L-threonylcarbamoyladenylate synthase
C4Q27_RS04230	COG0613	PHP domain protein
C4Q27_RS04235	COG2917	probably involved in intracellular septation
C4Q27_RS04240	COG2350	Protein conserved in bacteria
C4Q27_RS04255	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS04270	COG0778	Nitroreductase
C4Q27_RS04275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4Q27_RS04295	COG2207	Transcriptional regulator
C4Q27_RS04310	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4Q27_RS04320	COG0514	ATP-dependent DNA helicase (RecQ)
C4Q27_RS04335	COG2832	Protein of unknown function (DUF454)
C4Q27_RS04350	COG0840	transmembrane signaling receptor activity
C4Q27_RS04370	COG0583	DNA-binding transcription factor activity
C4Q27_RS04405	COG0513	Belongs to the DEAD box helicase family
C4Q27_RS04410	COG0668	transmembrane transport
C4Q27_RS04420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4Q27_RS04435	COG2267	carboxylic ester hydrolase activity
C4Q27_RS04455	COG2188	Transcriptional regulator
C4Q27_RS04465	COG1643	Atp-dependent helicase
C4Q27_RS04475	COG0174	glutamine synthetase
C4Q27_RS04480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS04485	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS04495	COG2267	carboxylic ester hydrolase activity
C4Q27_RS04500	COG2030	dehydratase
C4Q27_RS04505	COG4941	Belongs to the sigma-70 factor family
C4Q27_RS04515	COG3795	YCII-related domain
C4Q27_RS04535	COG0242	peptide deformylase activity
C4Q27_RS04540	COG1295	ribonuclease BN
C4Q27_RS04565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C4Q27_RS04590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4Q27_RS04610	COG1984	allophanate hydrolase subunit 2
C4Q27_RS04615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4Q27_RS04620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4Q27_RS04625	COG2814	Major facilitator Superfamily
C4Q27_RS04640	COG0121	glutamine amidotransferase
C4Q27_RS04685	COG2983	Belongs to the UPF0260 family
C4Q27_RS04700	COG3100	YcgL domain-containing protein
C4Q27_RS04720	COG0626	cystathionine gamma-synthase activity
C4Q27_RS04725	COG1522	sequence-specific DNA binding
C4Q27_RS04735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4Q27_RS04740	COG3781	membrane
C4Q27_RS04745	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4Q27_RS04765	COG0531	amino acid
C4Q27_RS04770	COG3938	Belongs to the proline racemase family
C4Q27_RS04775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4Q27_RS04790	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS04795	COG0640	Transcriptional regulator
C4Q27_RS04800	COG0579	oxidoreductase
C4Q27_RS04845	COG3657	addiction module killer protein
C4Q27_RS04860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4Q27_RS04865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4Q27_RS04870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4Q27_RS04875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4Q27_RS04885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4Q27_RS04895	COG0425	Belongs to the sulfur carrier protein TusA family
C4Q27_RS04905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4Q27_RS04910	COG5339	Protein conserved in bacteria
C4Q27_RS04915	COG0531	amino acid
C4Q27_RS04920	COG0840	transmembrane signaling receptor activity
C4Q27_RS04935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4Q27_RS04940	COG0602	queuosine metabolic process
C4Q27_RS04945	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4Q27_RS04950	COG2885	chlorophyll binding
C4Q27_RS04955	COG0823	Involved in the tonB-independent uptake of proteins
C4Q27_RS04975	COG0824	Thioesterase
C4Q27_RS04980	COG2255	four-way junction helicase activity
C4Q27_RS04985	COG0632	four-way junction helicase activity
C4Q27_RS04990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4Q27_RS04995	COG0217	transcriptional regulatory protein
C4Q27_RS05000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4Q27_RS05020	COG0783	Belongs to the Dps family
C4Q27_RS05030	COG2900	Belongs to the SlyX family
C4Q27_RS05045	COG0442	prolyl-tRNA aminoacylation
C4Q27_RS05055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4Q27_RS05085	COG3158	transport of potassium into the cell
C4Q27_RS05100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4Q27_RS05130	COG0519	Catalyzes the synthesis of GMP from XMP
C4Q27_RS05140	COG4807	Protein conserved in bacteria
C4Q27_RS05150	COG1301	dicarboxylic acid transport
C4Q27_RS05180	COG2205	protein histidine kinase activity
C4Q27_RS05185	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS05205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4Q27_RS05205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4Q27_RS05210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4Q27_RS05245	COG3077	Addiction module antitoxin, RelB DinJ family
C4Q27_RS05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q27_RS05265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4Q27_RS05290	COG0583	DNA-binding transcription factor activity
C4Q27_RS05300	COG0625	glutathione transferase activity
C4Q27_RS05305	COG3318	Belongs to the UPF0149 family
C4Q27_RS05305	COG3012	SEC-C Motif Domain Protein
C4Q27_RS05310	COG0252	asparaginase activity
C4Q27_RS05320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4Q27_RS05355	COG2116	formate transmembrane transporter activity
C4Q27_RS05360	COG3706	GGDEF domain
C4Q27_RS05365	COG5001	Diguanylate cyclase
C4Q27_RS05385	COG1289	transmembrane transporter activity
C4Q27_RS05400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4Q27_RS05410	COG2084	Dehydrogenase
C4Q27_RS05450	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4Q27_RS05455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4Q27_RS05470	COG0259	pyridoxamine-phosphate oxidase activity
C4Q27_RS05490	COG1199	ATP-dependent helicase activity
C4Q27_RS05520	COG3012	SEC-C Motif Domain Protein
C4Q27_RS05530	COG0653	protein targeting
C4Q27_RS05540	COG2814	Major facilitator Superfamily
C4Q27_RS05550	COG1045	serine acetyltransferase
C4Q27_RS05555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS05560	COG2366	antibiotic biosynthetic process
C4Q27_RS05565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4Q27_RS05565	COG1793	dna ligase
C4Q27_RS05570	COG1793	dna ligase
C4Q27_RS05580	COG1201	RNA secondary structure unwinding
C4Q27_RS05595	COG0717	Belongs to the dCTP deaminase family
C4Q27_RS05600	COG1278	Cold shock
C4Q27_RS05605	COG0489	protein tyrosine kinase activity
C4Q27_RS05610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4Q27_RS05610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4Q27_RS05625	COG4659	FMN binding
C4Q27_RS05635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4Q27_RS05640	COG2197	response regulator
C4Q27_RS05650	COG0137	argininosuccinate synthase activity
C4Q27_RS05670	COG0418	dihydroorotase activity
C4Q27_RS05675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4Q27_RS05680	COG0450	alkyl hydroperoxide reductase
C4Q27_RS05700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4Q27_RS05705	COG0243	molybdopterin cofactor binding
C4Q27_RS05710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4Q27_RS05715	COG3842	ATPase activity
C4Q27_RS05720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4Q27_RS05730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4Q27_RS05750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS05755	COG0765	amino acid transport
C4Q27_RS05760	COG0765	amino acid transport
C4Q27_RS05765	COG1126	abc transporter atp-binding protein
C4Q27_RS05785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4Q27_RS05790	COG0583	DNA-binding transcription factor activity
C4Q27_RS05795	COG0494	nUDIX hydrolase
C4Q27_RS05800	COG1201	RNA secondary structure unwinding
C4Q27_RS05805	COG0069	glutamate synthase activity
C4Q27_RS05810	COG1113	amino acid transport
C4Q27_RS05820	COG1695	Transcriptional regulator
C4Q27_RS05825	COG2375	cellular response to nickel ion
C4Q27_RS05870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4Q27_RS05905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4Q27_RS05910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4Q27_RS05925	COG0047	phosphoribosylformylglycinamidine synthase activity
C4Q27_RS05925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4Q27_RS05940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4Q27_RS05945	COG0590	tRNA wobble adenosine to inosine editing
C4Q27_RS05960	COG0519	Catalyzes the synthesis of GMP from XMP
C4Q27_RS05960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4Q27_RS05980	COG0583	DNA-binding transcription factor activity
C4Q27_RS05985	COG1570	exodeoxyribonuclease VII activity
C4Q27_RS05990	COG0739	heme binding
C4Q27_RS05995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4Q27_RS06005	COG0800	Aldolase
C4Q27_RS06020	COG1737	Transcriptional regulator
C4Q27_RS06025	COG0676	glucose-6-phosphate 1-epimerase activity
C4Q27_RS06035	COG3842	ATPase activity
C4Q27_RS06045	COG1175	transmembrane transport
C4Q27_RS06050	COG1653	transport
C4Q27_RS06135	COG2235	arginine
C4Q27_RS06140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4Q27_RS06160	COG0786	glutamate:sodium symporter activity
C4Q27_RS06165	COG4944	Protein of unknown function (DUF1109)
C4Q27_RS06170	COG1595	DNA-templated transcription, initiation
C4Q27_RS06180	COG3220	belongs to the UPF0276 family
C4Q27_RS06195	COG0509	glycine decarboxylation via glycine cleavage system
C4Q27_RS06200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4Q27_RS06200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4Q27_RS06205	COG1760	l-serine dehydratase
C4Q27_RS06210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4Q27_RS06215	COG1278	Cold shock
C4Q27_RS06225	COG0795	lipopolysaccharide-transporting ATPase activity
C4Q27_RS06230	COG0795	lipopolysaccharide-transporting ATPase activity
C4Q27_RS06240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4Q27_RS06255	COG0525	valine-tRNA ligase activity
C4Q27_RS06260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C4Q27_RS06265	COG0776	regulation of translation
C4Q27_RS06270	COG3081	Nucleoid-associated protein
C4Q27_RS06275	COG2827	Endonuclease containing a URI domain
C4Q27_RS06285	COG2807	transmembrane transport
C4Q27_RS06290	COG2186	Transcriptional regulator
C4Q27_RS06305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4Q27_RS06310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4Q27_RS06315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4Q27_RS06320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4Q27_RS06340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4Q27_RS06345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4Q27_RS06350	COG1127	ABC transporter
C4Q27_RS06360	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4Q27_RS06370	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4Q27_RS06375	COG1137	ATPase activity
C4Q27_RS06380	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4Q27_RS06385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4Q27_RS06395	COG1660	Displays ATPase and GTPase activities
C4Q27_RS06400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4Q27_RS06430	COG0312	modulator of DNA gyrase
C4Q27_RS06435	COG3028	Belongs to the UPF0307 family
C4Q27_RS06440	COG0312	modulator of DNA gyrase
C4Q27_RS06445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4Q27_RS06460	COG0424	maF-like protein
C4Q27_RS06470	COG1792	Involved in formation and maintenance of cell shape
C4Q27_RS06475	COG1077	Cell shape determining protein MreB Mrl
C4Q27_RS06480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4Q27_RS06485	COG0154	amidase activity
C4Q27_RS06490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4Q27_RS06510	COG1113	amino acid transport
C4Q27_RS06545	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS06555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q27_RS06560	COG0583	DNA-binding transcription factor activity
C4Q27_RS06570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4Q27_RS06575	COG3622	Belongs to the hyi family
C4Q27_RS06625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS06630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q27_RS06640	COG3642	lipopolysaccharide core region biosynthetic process
C4Q27_RS06650	COG0642	Histidine kinase
C4Q27_RS06675	COG3153	acetyltransferase
C4Q27_RS06675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4Q27_RS06690	COG0693	protein deglycase activity
C4Q27_RS06695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4Q27_RS06715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C4Q27_RS06730	COG0747	negative chemotaxis
C4Q27_RS06735	COG0747	negative chemotaxis
C4Q27_RS06750	COG0747	negative chemotaxis
C4Q27_RS06755	COG0601	transmembrane transport
C4Q27_RS06760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4Q27_RS06765	COG0444	Belongs to the ABC transporter superfamily
C4Q27_RS06770	COG4608	Belongs to the ABC transporter superfamily
C4Q27_RS06780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS06780	COG0723	plastoquinol--plastocyanin reductase activity
C4Q27_RS06795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4Q27_RS06820	COG4772	TonB-dependent receptor
C4Q27_RS06835	COG0019	diaminopimelate decarboxylase activity
C4Q27_RS06845	COG3128	pkhd-type hydroxylase
C4Q27_RS06850	COG4774	siderophore transport
C4Q27_RS06855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4Q27_RS06865	COG0436	Aminotransferase
C4Q27_RS06870	COG1160	GTP binding
C4Q27_RS06885	COG0124	histidyl-tRNA synthetase
C4Q27_RS06890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4Q27_RS06905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4Q27_RS06910	COG0105	UTP biosynthetic process
C4Q27_RS06920	COG0633	Ferredoxin
C4Q27_RS06925	COG0443	Heat shock 70 kDa protein
C4Q27_RS06930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4Q27_RS06935	COG0316	Belongs to the HesB IscA family
C4Q27_RS06945	COG1104	cysteine desulfurase activity
C4Q27_RS06955	COG1045	serine acetyltransferase
C4Q27_RS06975	COG3134	Outer membrane lipoprotein
C4Q27_RS06990	COG1862	Preprotein translocase
C4Q27_RS06995	COG0343	queuine tRNA-ribosyltransferase activity
C4Q27_RS07000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4Q27_RS07050	COG3657	addiction module killer protein
C4Q27_RS07055	COG3781	membrane
C4Q27_RS07060	COG3639	organic phosphonate transmembrane transporter activity
C4Q27_RS07065	COG3639	organic phosphonate transmembrane transporter activity
C4Q27_RS07070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4Q27_RS07075	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C4Q27_RS07080	COG0709	Synthesizes selenophosphate from selenide and ATP
C4Q27_RS07085	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C4Q27_RS07110	COG1595	DNA-templated transcription, initiation
C4Q27_RS07115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4Q27_RS07120	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4Q27_RS07130	COG0436	Aminotransferase
C4Q27_RS07135	COG0109	protoheme IX farnesyltransferase activity
C4Q27_RS07140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C4Q27_RS07145	COG1845	cytochrome c oxidase, subunit III
C4Q27_RS07150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4Q27_RS07155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4Q27_RS07160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4Q27_RS07170	COG1017	nitric oxide dioxygenase activity
C4Q27_RS07170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4Q27_RS07175	COG3604	Transcriptional regulator
C4Q27_RS07235	COG5001	Diguanylate cyclase
C4Q27_RS07235	COG2203	Gaf domain
C4Q27_RS07235	COG3706	GGDEF domain
C4Q27_RS07235	COG4251	negative regulation of phosphorylation
C4Q27_RS07245	COG3530	Putative quorum-sensing-regulated virulence factor
C4Q27_RS07250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4Q27_RS07250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4Q27_RS07250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4Q27_RS07255	COG1105	Belongs to the carbohydrate kinase PfkB family
C4Q27_RS07265	COG1609	Transcriptional regulator
C4Q27_RS07270	COG0084	hydrolase, TatD family'
C4Q27_RS07280	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4Q27_RS07295	COG0492	ferredoxin-NADP+ reductase activity
C4Q27_RS07300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C4Q27_RS07375	COG0857	belongs to the CobB CobQ family
C4Q27_RS07375	COG0280	phosphate acetyltransferase
C4Q27_RS07380	COG2885	chlorophyll binding
C4Q27_RS07385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4Q27_RS07425	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS07430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q27_RS07435	COG2813	Specifically methylates the guanine in position
C4Q27_RS07440	COG2119	membrane
C4Q27_RS07450	COG2135	peptidase activity
C4Q27_RS07490	COG0579	oxidoreductase
C4Q27_RS07515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4Q27_RS07520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4Q27_RS07530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4Q27_RS07535	COG1090	epimerase
C4Q27_RS07540	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C4Q27_RS07550	COG0789	Transcriptional regulator
C4Q27_RS07555	COG0415	Belongs to the DNA photolyase family
C4Q27_RS07560	COG4221	oxidoreductase activity
C4Q27_RS07570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4Q27_RS07575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4Q27_RS07585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4Q27_RS07590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4Q27_RS07610	COG0574	Belongs to the PEP-utilizing enzyme family
C4Q27_RS07610	COG3848	Pyruvate phosphate dikinase
C4Q27_RS07615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4Q27_RS07620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4Q27_RS07635	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4Q27_RS07640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4Q27_RS07650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4Q27_RS07655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4Q27_RS07660	COG0193	aminoacyl-tRNA hydrolase activity
C4Q27_RS07690	COG0628	permease
C4Q27_RS07700	COG2326	polyphosphate kinase activity
C4Q27_RS07705	COG1335	isochorismatase
C4Q27_RS07735	COG3264	Mechanosensitive ion channel
C4Q27_RS07735	COG1511	domain protein
C4Q27_RS07740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4Q27_RS07740	COG2169	Transcriptional regulator
C4Q27_RS07750	COG1595	DNA-templated transcription, initiation
C4Q27_RS07755	COG3712	iron ion homeostasis
C4Q27_RS07765	COG2223	nitrite transmembrane transporter activity
C4Q27_RS07800	COG0456	acetyltransferase
C4Q27_RS07835	COG3045	CreA protein
C4Q27_RS07840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4Q27_RS07845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4Q27_RS07850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4Q27_RS07855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4Q27_RS07860	COG0142	geranyltranstransferase activity
C4Q27_RS07865	COG2824	Alkylphosphonate utilization operon protein PhnA
C4Q27_RS07870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4Q27_RS07875	COG0545	Peptidyl-prolyl cis-trans isomerase
C4Q27_RS07890	COG2862	Uncharacterized protein family, UPF0114
C4Q27_RS07900	COG1067	ATP-dependent peptidase activity
C4Q27_RS07920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4Q27_RS07925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4Q27_RS07930	COG0488	(ABC) transporter
C4Q27_RS07950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4Q27_RS07965	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS07985	COG0583	DNA-binding transcription factor activity
C4Q27_RS07990	COG0833	amino acid
C4Q27_RS07995	COG0626	cystathionine gamma-synthase activity
C4Q27_RS08000	COG0646	methionine synthase
C4Q27_RS08000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4Q27_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS08010	COG0765	amino acid transport
C4Q27_RS08015	COG0039	L-malate dehydrogenase activity
C4Q27_RS08115	COG3344	reverse transcriptase
C4Q27_RS08125	COG2433	Pfam Transposase IS66
C4Q27_RS08150	COG3344	reverse transcriptase
C4Q27_RS08175	COG0237	dephospho-CoA kinase activity
C4Q27_RS08180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4Q27_RS08210	COG1252	NADH dehydrogenase
C4Q27_RS08240	COG0542	response to heat
C4Q27_RS08290	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4Q27_RS08315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS08345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4Q27_RS08350	COG1047	Peptidyl-prolyl cis-trans
C4Q27_RS08355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C4Q27_RS08360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4Q27_RS08365	COG0196	riboflavin kinase activity
C4Q27_RS08375	COG0268	Binds directly to 16S ribosomal RNA
C4Q27_RS08380	COG3008	intermembrane lipid transfer
C4Q27_RS08385	COG2995	paraquat-inducible protein a
C4Q27_RS08390	COG2995	paraquat-inducible protein a
C4Q27_RS08445	COG1309	transcriptional regulator
C4Q27_RS08455	COG0300	oxidoreductase activity
C4Q27_RS08460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4Q27_RS08475	COG2814	Major facilitator Superfamily
C4Q27_RS08490	COG2217	Heavy metal translocating P-type atpase
C4Q27_RS08505	COG2207	Transcriptional regulator
C4Q27_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS08520	COG2030	dehydratase
C4Q27_RS08530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4Q27_RS08575	COG2373	Large extracellular alpha-helical protein
C4Q27_RS08580	COG0534	Mate efflux family protein
C4Q27_RS08595	COG1166	arginine decarboxylase activity
C4Q27_RS08600	COG0023	Translation Initiation Factor
C4Q27_RS08635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4Q27_RS08650	COG3284	Transcriptional regulator
C4Q27_RS08655	COG3199	ATP-NAD kinase
C4Q27_RS08660	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4Q27_RS08665	COG0022	dehydrogenase e1 component
C4Q27_RS08675	COG1063	alcohol dehydrogenase
C4Q27_RS08685	COG0702	epimerase
C4Q27_RS08700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4Q27_RS08705	COG3284	Transcriptional regulator
C4Q27_RS08720	COG0531	amino acid
C4Q27_RS08725	COG4303	Ethanolamine ammonia lyase large subunit
C4Q27_RS08730	COG4302	ethanolamine ammonia-lyase activity
C4Q27_RS08735	COG0456	acetyltransferase
C4Q27_RS08740	COG0586	Pfam SNARE associated Golgi protein
C4Q27_RS08745	COG3228	Belongs to the MtfA family
C4Q27_RS08750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4Q27_RS08780	COG2819	hydrolase of the alpha beta superfamily
C4Q27_RS08790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4Q27_RS08795	COG1722	exodeoxyribonuclease VII activity
C4Q27_RS08800	COG0142	geranyltranstransferase activity
C4Q27_RS08805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4Q27_RS08815	COG4206	TonB-dependent receptor
C4Q27_RS08820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4Q27_RS08830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4Q27_RS08840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4Q27_RS08845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4Q27_RS08850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4Q27_RS08855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4Q27_RS08870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4Q27_RS08870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4Q27_RS08875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4Q27_RS08885	COG2264	protein methyltransferase activity
C4Q27_RS08890	COG3118	belongs to the thioredoxin family
C4Q27_RS08925	COG3047	cAMP biosynthetic process
C4Q27_RS08930	COG2814	Major facilitator Superfamily
C4Q27_RS08955	COG2267	carboxylic ester hydrolase activity
C4Q27_RS08965	COG1115	amino acid carrier protein
C4Q27_RS08970	COG0252	asparaginase activity
C4Q27_RS08980	COG3276	selenocysteine insertion sequence binding
C4Q27_RS08985	COG1921	L-seryl-tRNASec selenium transferase activity
C4Q27_RS08990	COG3058	Necessary for formate dehydrogenase activity
C4Q27_RS08995	COG2864	formate dehydrogenase
C4Q27_RS09000	COG0437	4 iron, 4 sulfur cluster binding
C4Q27_RS09005	COG0243	molybdopterin cofactor binding
C4Q27_RS09005	COG3383	formate dehydrogenase (NAD+) activity
C4Q27_RS09010	COG3383	formate dehydrogenase (NAD+) activity
C4Q27_RS09010	COG0243	molybdopterin cofactor binding
C4Q27_RS09015	COG4221	oxidoreductase activity
C4Q27_RS09020	COG0730	response to heat
C4Q27_RS09025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS09030	COG0629	single-stranded DNA binding
C4Q27_RS09035	COG2814	Major facilitator Superfamily
C4Q27_RS09040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4Q27_RS09045	COG2193	ferroxidase activity
C4Q27_RS09050	COG0753	catalase activity
C4Q27_RS09055	COG0203	ribosomal protein L17
C4Q27_RS09060	COG0202	RNA polymerase activity
C4Q27_RS09065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4Q27_RS09070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4Q27_RS09075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4Q27_RS09080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4Q27_RS09090	COG0200	Binds to the 23S rRNA
C4Q27_RS09095	COG1841	ribosomal large subunit assembly
C4Q27_RS09100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4Q27_RS09105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4Q27_RS09110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4Q27_RS09115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4Q27_RS09120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C4Q27_RS09125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4Q27_RS09130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4Q27_RS09135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4Q27_RS09140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4Q27_RS09145	COG0255	Belongs to the universal ribosomal protein uL29 family
C4Q27_RS09150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4Q27_RS09155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4Q27_RS09160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4Q27_RS09165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4Q27_RS09170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4Q27_RS09175	COG0089	rRNA binding
C4Q27_RS09180	COG0088	Forms part of the polypeptide exit tunnel
C4Q27_RS09185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4Q27_RS09190	COG0051	transcription antitermination factor activity, RNA binding
C4Q27_RS09195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4Q27_RS09200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4Q27_RS09205	COG0049	tRNA binding
C4Q27_RS09210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4Q27_RS09215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4Q27_RS09220	COG0085	RNA polymerase activity
C4Q27_RS09225	COG0222	ribosome binding
C4Q27_RS09230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4Q27_RS09235	COG0081	regulation of translation
C4Q27_RS09240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4Q27_RS09260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4Q27_RS09285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4Q27_RS09290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4Q27_RS09290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4Q27_RS09310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4Q27_RS09320	COG0739	heme binding
C4Q27_RS09325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4Q27_RS09330	COG0316	Belongs to the HesB IscA family
C4Q27_RS09335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4Q27_RS09340	COG1981	membrane
C4Q27_RS09350	COG0300	oxidoreductase activity
C4Q27_RS09355	COG0537	adenosine 5'-monophosphoramidase activity
C4Q27_RS09360	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4Q27_RS09370	COG1765	OsmC-like protein
C4Q27_RS09385	COG0134	indole-3-glycerol-phosphate synthase activity
C4Q27_RS09390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4Q27_RS09395	COG0512	Glutamine amidotransferase of anthranilate synthase
C4Q27_RS09400	COG3240	lipase activity
C4Q27_RS09400	COG4625	pathogenesis
C4Q27_RS09405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4Q27_RS09410	COG0546	phosphoglycolate phosphatase activity
C4Q27_RS09415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4Q27_RS09425	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4Q27_RS09435	COG3842	ATPase activity
C4Q27_RS09440	COG2197	response regulator
C4Q27_RS09460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4Q27_RS09465	COG3178	'Phosphotransferase
C4Q27_RS09470	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4Q27_RS09475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4Q27_RS09480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4Q27_RS09485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4Q27_RS09490	COG2967	ApaG domain
C4Q27_RS09495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4Q27_RS09500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4Q27_RS09505	COG2766	serine protein kinase
C4Q27_RS09510	COG2718	Belongs to the UPF0229 family
C4Q27_RS09515	COG2719	SpoVR family
C4Q27_RS09520	COG0617	tRNA 3'-terminal CCA addition
C4Q27_RS09535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4Q27_RS09540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4Q27_RS09545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C4Q27_RS09550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4Q27_RS09555	COG0358	DNA primase activity
C4Q27_RS09595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4Q27_RS09615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4Q27_RS09620	COG1025	Belongs to the peptidase M16 family
C4Q27_RS09630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4Q27_RS09640	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C4Q27_RS09650	COG0535	radical SAM domain protein
C4Q27_RS09665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4Q27_RS09670	COG0583	DNA-binding transcription factor activity
C4Q27_RS09675	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS09680	COG3706	GGDEF domain
C4Q27_RS09710	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS09740	COG0156	8-amino-7-oxononanoate synthase activity
C4Q27_RS09745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4Q27_RS09750	COG1040	competence protein
C4Q27_RS09755	COG3585	molybdate ion transport
C4Q27_RS09755	COG2005	Transcriptional regulator
C4Q27_RS09760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4Q27_RS09775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4Q27_RS09790	COG2176	DNA-directed DNA polymerase activity
C4Q27_RS09795	COG1595	DNA-templated transcription, initiation
C4Q27_RS09800	COG3712	iron ion homeostasis
C4Q27_RS09810	COG4774	siderophore transport
C4Q27_RS09850	COG0438	transferase activity, transferring glycosyl groups
C4Q27_RS09865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4Q27_RS09885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4Q27_RS09895	COG4452	Inner membrane protein CreD
C4Q27_RS09900	COG2205	protein histidine kinase activity
C4Q27_RS09905	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS09915	COG0204	Acyl-transferase
C4Q27_RS09920	COG0531	amino acid
C4Q27_RS09935	COG1063	alcohol dehydrogenase
C4Q27_RS09965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4Q27_RS09975	COG0840	transmembrane signaling receptor activity
C4Q27_RS10000	COG1017	nitric oxide dioxygenase activity
C4Q27_RS10000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4Q27_RS10025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4Q27_RS10030	COG0247	lactate metabolic process
C4Q27_RS10030	COG2181	nitrate reductase activity
C4Q27_RS10035	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4Q27_RS10035	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS10075	COG3246	L-lysine catabolic process to acetate
C4Q27_RS10080	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4Q27_RS10090	COG3291	Pkd domain containing protein
C4Q27_RS10105	COG1760	l-serine dehydratase
C4Q27_RS10115	COG4176	ABC-type proline glycine betaine transport system permease component
C4Q27_RS10120	COG4175	Glycine betaine
C4Q27_RS10125	COG0107	imidazoleglycerol-phosphate synthase activity
C4Q27_RS10130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4Q27_RS10140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4Q27_RS10145	COG0131	Imidazoleglycerol-phosphate dehydratase
C4Q27_RS10150	COG2223	nitrite transmembrane transporter activity
C4Q27_RS10165	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4Q27_RS10200	COG4215	(ABC) transporter
C4Q27_RS10265	COG4249	Peptidase C14 caspase catalytic subunit p20
C4Q27_RS10285	COG3712	iron ion homeostasis
C4Q27_RS10290	COG1595	DNA-templated transcription, initiation
C4Q27_RS10325	COG0069	glutamate synthase activity
C4Q27_RS10345	COG2957	Belongs to the agmatine deiminase family
C4Q27_RS10375	COG0494	nUDIX hydrolase
C4Q27_RS10380	COG1011	Hydrolase
C4Q27_RS10385	COG1652	LysM domain
C4Q27_RS10390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4Q27_RS10410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C4Q27_RS10420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C4Q27_RS10430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4Q27_RS10435	COG4067	protein conserved in archaea
C4Q27_RS10435	COG0189	ligase activity
C4Q27_RS10440	COG0189	ligase activity
C4Q27_RS10455	COG2183	response to ionizing radiation
C4Q27_RS10465	COG2918	glutathione biosynthetic process
C4Q27_RS10485	COG1116	anion transmembrane transporter activity
C4Q27_RS10490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4Q27_RS10495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS10500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS10505	COG0431	NADPH-dependent FMN reductase
C4Q27_RS10510	COG0450	alkyl hydroperoxide reductase
C4Q27_RS10520	COG4521	taurine ABC transporter
C4Q27_RS10525	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4Q27_RS10530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4Q27_RS10535	COG2175	clavaminate synthase activity
C4Q27_RS10545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4Q27_RS10550	COG1045	serine acetyltransferase
C4Q27_RS10555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS10560	COG0765	amino acid transport
C4Q27_RS10565	COG1126	abc transporter atp-binding protein
C4Q27_RS10585	COG1464	Belongs to the NlpA lipoprotein family
C4Q27_RS10590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4Q27_RS10595	COG2011	ABC-type metal ion transport system permease component
C4Q27_RS10610	COG2199	diguanylate cyclase activity
C4Q27_RS10620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4Q27_RS10625	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS10645	COG0517	IMP dehydrogenase activity
C4Q27_RS10645	COG0516	GMP reductase activity
C4Q27_RS10675	COG1280	lysine exporter protein (LysE YggA)
C4Q27_RS10690	COG0488	(ABC) transporter
C4Q27_RS10715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4Q27_RS10730	COG0181	hydroxymethylbilane synthase activity
C4Q27_RS10740	COG0165	Argininosuccinate lyase
C4Q27_RS10750	COG0625	glutathione transferase activity
C4Q27_RS10765	COG0672	)-iron permease
C4Q27_RS10775	COG1566	PFAM secretion protein HlyD family protein
C4Q27_RS10785	COG1289	transmembrane transporter activity
C4Q27_RS10805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4Q27_RS10820	COG2175	clavaminate synthase activity
C4Q27_RS10845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS10850	COG5001	Diguanylate cyclase
C4Q27_RS10850	COG3300	MHYT domain
C4Q27_RS10860	COG1802	Transcriptional regulator
C4Q27_RS10865	COG1595	DNA-templated transcription, initiation
C4Q27_RS10930	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS10935	COG0583	DNA-binding transcription factor activity
C4Q27_RS10955	COG0427	acetyl-CoA hydrolase
C4Q27_RS10990	COG2851	Citrate transporter
C4Q27_RS10995	COG0861	Integral membrane protein TerC family
C4Q27_RS11000	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4Q27_RS11015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4Q27_RS11020	COG1127	ABC transporter
C4Q27_RS11035	COG0700	Nucleoside recognition
C4Q27_RS11040	COG1301	dicarboxylic acid transport
C4Q27_RS11065	COG2204	response regulator
C4Q27_RS11070	COG5002	protein histidine kinase activity
C4Q27_RS11075	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4Q27_RS11080	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4Q27_RS11095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4Q27_RS11105	COG3245	cytochrome
C4Q27_RS11110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4Q27_RS11130	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4Q27_RS11135	COG0735	belongs to the Fur family
C4Q27_RS11140	COG1121	(ABC) transporter
C4Q27_RS11145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4Q27_RS11160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4Q27_RS11165	COG2011	ABC-type metal ion transport system permease component
C4Q27_RS11185	COG0109	protoheme IX farnesyltransferase activity
C4Q27_RS11190	COG1612	heme a metabolic process
C4Q27_RS11215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C4Q27_RS11220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4Q27_RS11225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4Q27_RS11235	COG0659	secondary active sulfate transmembrane transporter activity
C4Q27_RS11255	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4Q27_RS11260	COG0339	signal peptide processing
C4Q27_RS11265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4Q27_RS11295	COG1764	response to oxidative stress
C4Q27_RS11300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS11310	COG3360	Dodecin
C4Q27_RS11325	COG0133	tryptophan synthase activity
C4Q27_RS11330	COG0159	tryptophan synthase activity
C4Q27_RS11350	COG3119	arylsulfatase activity
C4Q27_RS11365	COG0659	secondary active sulfate transmembrane transporter activity
C4Q27_RS11370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4Q27_RS11375	COG0408	coproporphyrinogen oxidase activity
C4Q27_RS11400	COG0009	L-threonylcarbamoyladenylate synthase
C4Q27_RS11405	COG0758	DNA mediated transformation
C4Q27_RS11410	COG0242	peptide deformylase activity
C4Q27_RS11415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4Q27_RS11420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4Q27_RS11425	COG0569	domain protein
C4Q27_RS11440	COG2818	Glycosylase
C4Q27_RS11445	COG0752	glycyl-tRNA synthetase alpha subunit
C4Q27_RS11450	COG0751	glycine-tRNA ligase activity
C4Q27_RS11455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4Q27_RS11465	COG0477	Major facilitator Superfamily
C4Q27_RS11505	COG0187	DNA topoisomerase II activity
C4Q27_RS11510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4Q27_RS11515	COG0592	DNA-directed DNA polymerase activity
C4Q27_RS11520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4Q27_RS11525	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4Q27_RS11530	COG0594	ribonuclease P activity
C4Q27_RS11535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4Q27_RS11540	COG0706	membrane insertase activity
C4Q27_RS11545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4Q27_RS11550	COG0445	tRNA wobble uridine modification
C4Q27_RS11555	COG0357	Ribosomal RNA small subunit methyltransferase G
C4Q27_RS11560	COG1192	Involved in chromosome partitioning
C4Q27_RS11565	COG1475	DNA binding
C4Q27_RS11570	COG3312	ion transport
C4Q27_RS11575	COG0356	it plays a direct role in the translocation of protons across the membrane
C4Q27_RS11585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4Q27_RS11590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4Q27_RS11595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4Q27_RS11600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4Q27_RS11605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4Q27_RS11610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4Q27_RS11615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4Q27_RS11620	COG1349	DNA-binding transcription factor activity
C4Q27_RS11625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4Q27_RS11720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q27_RS11820	COG2194	sulfuric ester hydrolase activity
C4Q27_RS11840	COG0640	Transcriptional regulator
C4Q27_RS11845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4Q27_RS11850	COG0798	PFAM Bile acid sodium symporter
C4Q27_RS11855	COG0431	NADPH-dependent FMN reductase
C4Q27_RS11865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4Q27_RS11895	COG2433	Pfam Transposase IS66
C4Q27_RS11900	COG0494	nUDIX hydrolase
C4Q27_RS11905	COG0589	response to stress
C4Q27_RS11910	COG0659	secondary active sulfate transmembrane transporter activity
C4Q27_RS11920	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS11940	COG0583	DNA-binding transcription factor activity
C4Q27_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS11950	COG2271	Major facilitator Superfamily
C4Q27_RS11955	COG3959	Transketolase, thiamine diphosphate binding domain
C4Q27_RS11960	COG3958	Transketolase
C4Q27_RS11965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q27_RS11970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4Q27_RS11975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4Q27_RS12000	COG0523	cobalamin synthesis protein
C4Q27_RS12010	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4Q27_RS12015	COG1607	acyl-coa hydrolase
C4Q27_RS12020	COG4651	solute:proton antiporter activity
C4Q27_RS12020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4Q27_RS12035	COG0210	DNA helicase
C4Q27_RS12040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4Q27_RS12055	COG0583	DNA-binding transcription factor activity
C4Q27_RS12060	COG0439	Biotin carboxylase
C4Q27_RS12065	COG0511	ligase activity, forming carbon-carbon bonds
C4Q27_RS12065	COG5016	pyruvate
C4Q27_RS12105	COG1027	Aspartate ammonia-lyase
C4Q27_RS12110	COG0583	DNA-binding transcription factor activity
C4Q27_RS12145	COG1607	acyl-coa hydrolase
C4Q27_RS12150	COG0477	Major facilitator Superfamily
C4Q27_RS12165	COG0581	inorganic phosphate transmembrane transporter activity
C4Q27_RS12170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4Q27_RS12175	COG0704	Plays a role in the regulation of phosphate uptake
C4Q27_RS12185	COG0739	heme binding
C4Q27_RS12190	COG1253	flavin adenine dinucleotide binding
C4Q27_RS12210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4Q27_RS12215	COG3161	chorismate lyase activity
C4Q27_RS12250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4Q27_RS12255	COG0583	DNA-binding transcription factor activity
C4Q27_RS12265	COG0848	biopolymer transport protein
C4Q27_RS12290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4Q27_RS12295	COG1758	RNA polymerase activity
C4Q27_RS12305	COG0174	glutamine synthetase
C4Q27_RS12310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4Q27_RS12320	COG0194	GDP metabolic process
C4Q27_RS12325	COG1561	YicC-like family, N-terminal region
C4Q27_RS12330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4Q27_RS12340	COG0708	Exodeoxyribonuclease III
C4Q27_RS12345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4Q27_RS12350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4Q27_RS12355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4Q27_RS12360	COG0756	dUTP diphosphatase activity
C4Q27_RS12365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4Q27_RS12370	COG2003	Belongs to the UPF0758 family
C4Q27_RS12375	COG0747	negative chemotaxis
C4Q27_RS12380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4Q27_RS12385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4Q27_RS12400	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS12410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4Q27_RS12415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS12425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS12440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS12445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4Q27_RS12465	COG0427	acetyl-CoA hydrolase
C4Q27_RS12470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C4Q27_RS12485	COG0534	Mate efflux family protein
C4Q27_RS12495	COG5383	Protein conserved in bacteria
C4Q27_RS12500	COG0583	DNA-binding transcription factor activity
C4Q27_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS12510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS12520	COG1335	isochorismatase
C4Q27_RS12550	COG0583	DNA-binding transcription factor activity
C4Q27_RS12555	COG1335	isochorismatase
C4Q27_RS12590	COG1335	isochorismatase
C4Q27_RS12595	COG4191	Histidine kinase
C4Q27_RS12600	COG4566	intracellular signal transduction
C4Q27_RS12610	COG0606	chelatase, subunit chli
C4Q27_RS12630	COG0347	Belongs to the P(II) protein family
C4Q27_RS12635	COG0004	ammonium transporteR
C4Q27_RS12650	COG0546	phosphoglycolate phosphatase activity
C4Q27_RS12655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4Q27_RS12665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4Q27_RS12670	COG0019	diaminopimelate decarboxylase activity
C4Q27_RS12680	COG1965	Belongs to the frataxin family
C4Q27_RS12690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4Q27_RS12700	COG1671	Belongs to the UPF0178 family
C4Q27_RS12705	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4Q27_RS12720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4Q27_RS12725	COG0248	Ppx GppA phosphatase
C4Q27_RS12745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4Q27_RS12770	COG0842	Transport permease protein
C4Q27_RS12775	COG1129	ABC transporter
C4Q27_RS12775	COG0842	Transport permease protein
C4Q27_RS12780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS12790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4Q27_RS12810	COG3079	Belongs to the UPF0149 family
C4Q27_RS12815	COG0006	proline dipeptidase activity
C4Q27_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4Q27_RS12830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4Q27_RS12840	COG1178	ABC-type Fe3 transport system permease component
C4Q27_RS12845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4Q27_RS12850	COG0509	glycine decarboxylation via glycine cleavage system
C4Q27_RS12855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4Q27_RS12855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4Q27_RS12875	COG1522	sequence-specific DNA binding
C4Q27_RS12885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4Q27_RS12890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4Q27_RS12890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4Q27_RS12895	COG0174	glutamine synthetase
C4Q27_RS12905	COG0174	glutamine synthetase
C4Q27_RS12925	COG3842	ATPase activity
C4Q27_RS12930	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4Q27_RS12935	COG1177	transmembrane transport
C4Q27_RS12965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q27_RS12975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4Q27_RS12990	COG4208	sulfate ABC transporter
C4Q27_RS12995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4Q27_RS13005	COG3829	transcription factor binding
C4Q27_RS13045	COG1683	Conserved Protein
C4Q27_RS13060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4Q27_RS13065	COG0277	FAD linked oxidase domain protein
C4Q27_RS13070	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4Q27_RS13080	COG3204	pilus organization
C4Q27_RS13085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4Q27_RS13090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4Q27_RS13105	COG0494	nUDIX hydrolase
C4Q27_RS13110	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C4Q27_RS13120	COG0730	response to heat
C4Q27_RS13125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C4Q27_RS13130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4Q27_RS13135	COG0789	Transcriptional regulator
C4Q27_RS13145	COG0583	DNA-binding transcription factor activity
C4Q27_RS13155	COG3842	ATPase activity
C4Q27_RS13160	COG1178	ABC-type Fe3 transport system permease component
C4Q27_RS13165	COG1840	ABC-type Fe3 transport system, periplasmic component
C4Q27_RS13175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4Q27_RS13190	COG1823	symporter activity
C4Q27_RS13200	COG0129	dihydroxy-acid dehydratase activity
C4Q27_RS13205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4Q27_RS13215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4Q27_RS13225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4Q27_RS13230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4Q27_RS13235	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4Q27_RS13275	COG0742	ribosomal rna small subunit methyltransferase
C4Q27_RS13280	COG0612	Peptidase, M16
C4Q27_RS13285	COG0612	Peptidase, M16
C4Q27_RS13295	COG0552	protein localization to endoplasmic reticulum
C4Q27_RS13300	COG2884	Cell division ATP-binding protein ftsE
C4Q27_RS13305	COG2177	Part of the ABC transporter FtsEX involved in
C4Q27_RS13315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4Q27_RS13320	COG2363	Small membrane protein
C4Q27_RS13330	COG2022	thiamine diphosphate biosynthetic process
C4Q27_RS13335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4Q27_RS13355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4Q27_RS13360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4Q27_RS13370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4Q27_RS13370	COG2813	Specifically methylates the guanine in position
C4Q27_RS13375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4Q27_RS13405	COG0791	NLP P60 protein
C4Q27_RS13420	COG0018	arginyl-trna synthetase
C4Q27_RS13425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4Q27_RS13430	COG0254	rRNA binding
C4Q27_RS13440	COG0281	malic enzyme
C4Q27_RS13470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4Q27_RS13475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4Q27_RS13485	COG0069	glutamate synthase activity
C4Q27_RS13485	COG0070	glutamate synthase
C4Q27_RS13485	COG0067	glutamate synthase
C4Q27_RS13490	COG0493	'glutamate synthase
C4Q27_RS13495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4Q27_RS13505	COG2814	Major facilitator Superfamily
C4Q27_RS13510	COG0583	DNA-binding transcription factor activity
C4Q27_RS13515	COG1192	Involved in chromosome partitioning
C4Q27_RS13520	COG3118	belongs to the thioredoxin family
C4Q27_RS13530	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4Q27_RS13535	COG1196	nuclear chromosome segregation
C4Q27_RS13535	COG3264	Mechanosensitive ion channel
C4Q27_RS13540	COG3263	regulation of cellular component size
C4Q27_RS13550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C4Q27_RS13555	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS13560	COG1309	transcriptional regulator
C4Q27_RS13565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4Q27_RS13575	COG2861	carbohydrate metabolic process
C4Q27_RS13580	COG0793	Belongs to the peptidase S41A family
C4Q27_RS13585	COG4942	peptidase
C4Q27_RS13590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4Q27_RS13595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4Q27_RS13605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4Q27_RS13610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4Q27_RS13650	COG3852	Histidine kinase
C4Q27_RS13665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4Q27_RS13665	COG0301	tRNA thio-modification
C4Q27_RS13670	COG1217	gtp-binding protein TYPA
C4Q27_RS13680	COG0058	SHG alpha-glucan phosphorylase activity
C4Q27_RS13685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4Q27_RS13705	COG0402	S-adenosylhomocysteine deaminase activity
C4Q27_RS13710	COG2188	Transcriptional regulator
C4Q27_RS13730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C4Q27_RS13735	COG2986	histidine ammonia-lyase
C4Q27_RS13745	COG1228	amidohydrolase
C4Q27_RS13760	COG1490	D-aminoacyl-tRNA deacylase activity
C4Q27_RS13765	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4Q27_RS13770	COG2943	transferase activity, transferring hexosyl groups
C4Q27_RS13780	COG0765	amino acid transport
C4Q27_RS13785	COG1126	abc transporter atp-binding protein
C4Q27_RS13795	COG0840	transmembrane signaling receptor activity
C4Q27_RS13810	COG0840	transmembrane signaling receptor activity
C4Q27_RS13830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4Q27_RS13835	COG0140	phosphoribosyl-ATP diphosphatase activity
C4Q27_RS13840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4Q27_RS13845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4Q27_RS13855	COG2226	methyltransferase
C4Q27_RS13905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4Q27_RS13910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C4Q27_RS13915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4Q27_RS13920	COG0540	Belongs to the ATCase OTCase family
C4Q27_RS13925	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4Q27_RS13930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4Q27_RS13935	COG1678	Uncharacterized ACR, COG1678
C4Q27_RS13950	COG0189	ligase activity
C4Q27_RS13985	COG1272	protein, Hemolysin III
C4Q27_RS13990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4Q27_RS14005	COG3038	cytochrome b561
C4Q27_RS14010	COG2353	YceI-like domain
C4Q27_RS14015	COG0513	Belongs to the DEAD box helicase family
C4Q27_RS14035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4Q27_RS14040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4Q27_RS14085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4Q27_RS14090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4Q27_RS14095	COG0640	Transcriptional regulator
C4Q27_RS14100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4Q27_RS14105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4Q27_RS14110	COG0126	phosphoglycerate kinase activity
C4Q27_RS14135	COG1451	nucleotide metabolic process
C4Q27_RS14145	COG2153	protein acetylation
C4Q27_RS14150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS14155	COG1289	transmembrane transporter activity
C4Q27_RS14160	COG2081	HI0933 family
C4Q27_RS14165	COG0513	Belongs to the DEAD box helicase family
C4Q27_RS14170	COG0477	Major facilitator Superfamily
C4Q27_RS14175	COG0312	modulator of DNA gyrase
C4Q27_RS14185	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS14200	COG0506	proline dehydrogenase activity
C4Q27_RS14200	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4Q27_RS14200	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4Q27_RS14205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4Q27_RS14210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4Q27_RS14215	COG2192	nodulation
C4Q27_RS14220	COG0438	transferase activity, transferring glycosyl groups
C4Q27_RS14245	COG0438	transferase activity, transferring glycosyl groups
C4Q27_RS14260	COG1132	(ABC) transporter
C4Q27_RS14265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4Q27_RS14265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4Q27_RS14275	COG0667	Aldo Keto reductase
C4Q27_RS14290	COG0583	DNA-binding transcription factor activity
C4Q27_RS14295	COG1519	Transferase
C4Q27_RS14300	COG2274	protein secretion by the type I secretion system
C4Q27_RS14320	COG1538	Outer membrane efflux protein
C4Q27_RS14325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4Q27_RS14345	COG0494	nUDIX hydrolase
C4Q27_RS14355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4Q27_RS14360	COG3150	esterase
C4Q27_RS14375	COG3577	Aspartyl protease
C4Q27_RS14400	COG0560	Phosphoserine phosphatase
C4Q27_RS14400	COG3830	Belongs to the UPF0237 family
C4Q27_RS14415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4Q27_RS14425	COG1162	GTPase activity
C4Q27_RS14430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4Q27_RS14435	COG2860	membrane
C4Q27_RS14445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4Q27_RS14445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4Q27_RS14450	COG0802	atpase or kinase
C4Q27_RS14455	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4Q27_RS14460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4Q27_RS14465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4Q27_RS14470	COG1923	regulation of RNA biosynthetic process
C4Q27_RS14475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4Q27_RS14480	COG0330	HflC and HflK could
C4Q27_RS14485	COG0330	HflC and HflK could
C4Q27_RS14490	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4Q27_RS14495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4Q27_RS14510	COG1178	ABC-type Fe3 transport system permease component
C4Q27_RS14515	COG1840	ABC-type Fe3 transport system, periplasmic component
C4Q27_RS14535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4Q27_RS14540	COG0360	Binds together with S18 to 16S ribosomal RNA
C4Q27_RS14545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4Q27_RS14555	COG0359	binds to the 23S rRNA
C4Q27_RS14560	COG0305	Participates in initiation and elongation during chromosome replication
C4Q27_RS14565	COG1132	(ABC) transporter
C4Q27_RS14585	COG1032	radical SAM domain protein
C4Q27_RS14600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4Q27_RS14605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C4Q27_RS14640	COG4221	oxidoreductase activity
C4Q27_RS14670	COG2982	Protein involved in outer membrane biogenesis
C4Q27_RS14685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C4Q27_RS14690	COG0697	spore germination
C4Q27_RS14720	COG0443	Heat shock 70 kDa protein
C4Q27_RS14725	COG0484	heat shock protein binding
C4Q27_RS14730	COG0789	Transcriptional regulator
C4Q27_RS14745	COG0411	ABC transporter
C4Q27_RS14765	COG1113	amino acid transport
C4Q27_RS14775	COG4774	siderophore transport
C4Q27_RS14795	COG0330	HflC and HflK could
C4Q27_RS14810	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C4Q27_RS14820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4Q27_RS14855	COG2095	MarC family integral membrane protein
C4Q27_RS14865	COG0151	Belongs to the GarS family
C4Q27_RS14870	COG0138	bifunctional purine biosynthesis protein purh
C4Q27_RS14880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4Q27_RS14890	COG2264	protein methyltransferase activity
C4Q27_RS14905	COG1346	cytolysis
C4Q27_RS14915	COG0586	Pfam SNARE associated Golgi protein
C4Q27_RS14920	COG2094	Belongs to the DNA glycosylase MPG family
C4Q27_RS14925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4Q27_RS14930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4Q27_RS14940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4Q27_RS14945	COG0768	penicillin binding
C4Q27_RS14950	COG0772	Belongs to the SEDS family
C4Q27_RS14955	COG2951	lytic endotransglycosylase activity
C4Q27_RS14965	COG1686	Belongs to the peptidase S11 family
C4Q27_RS14970	COG2921	Belongs to the UPF0250 family
C4Q27_RS14975	COG0321	lipoyl(octanoyl) transferase activity
C4Q27_RS14980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4Q27_RS14985	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4Q27_RS14990	COG2951	lytic endotransglycosylase activity
C4Q27_RS15015	COG0495	leucyl-tRNA aminoacylation
C4Q27_RS15030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4Q27_RS15035	COG4535	Mg2 and Co2 transporter CorC
C4Q27_RS15040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4Q27_RS15045	COG1702	phosphate starvation-inducible protein PhoH
C4Q27_RS15060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4Q27_RS15065	COG0352	thiamine-phosphate diphosphorylase activity
C4Q27_RS15070	COG0351	phosphomethylpyrimidine kinase
C4Q27_RS15075	COG3850	Histidine kinase
C4Q27_RS15075	COG4999	Histidine kinase
C4Q27_RS15075	COG3437	response regulator, receiver
C4Q27_RS15075	COG2205	protein histidine kinase activity
C4Q27_RS15085	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS15090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4Q27_RS15105	COG1522	sequence-specific DNA binding
C4Q27_RS15125	COG1643	Atp-dependent helicase
C4Q27_RS15140	COG3416	Protein conserved in bacteria
C4Q27_RS15155	COG0697	spore germination
C4Q27_RS15160	COG0513	Belongs to the DEAD box helicase family
C4Q27_RS15170	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4Q27_RS15175	COG0406	alpha-ribazole phosphatase activity
C4Q27_RS15185	COG1946	Acyl-CoA thioesterase
C4Q27_RS15190	COG0546	phosphoglycolate phosphatase activity
C4Q27_RS15200	COG0604	alcohol dehydrogenase
C4Q27_RS15200	COG3321	synthase
C4Q27_RS15250	COG2826	transposase and inactivated derivatives, IS30 family
C4Q27_RS15300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4Q27_RS15390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4Q27_RS15390	COG2885	chlorophyll binding
C4Q27_RS15460	COG4774	siderophore transport
C4Q27_RS15535	COG1304	FMN binding
C4Q27_RS15540	COG1620	l-lactate permease
C4Q27_RS15545	COG2186	Transcriptional regulator
C4Q27_RS15550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4Q27_RS15560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4Q27_RS15565	COG0735	belongs to the Fur family
C4Q27_RS15570	COG0497	DNA recombination
C4Q27_RS15575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4Q27_RS15580	COG0443	Heat shock 70 kDa protein
C4Q27_RS15585	COG0484	heat shock protein binding
C4Q27_RS15590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4Q27_RS15595	COG0505	Belongs to the CarA family
C4Q27_RS15600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4Q27_RS15605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4Q27_RS15620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4Q27_RS15630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4Q27_RS15635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4Q27_RS15640	COG0149	triose-phosphate isomerase activity
C4Q27_RS15645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4Q27_RS15660	COG0779	Required for maturation of 30S ribosomal subunits
C4Q27_RS15665	COG0195	Participates in both transcription termination and antitermination
C4Q27_RS15670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4Q27_RS15675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4Q27_RS15680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4Q27_RS15685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4Q27_RS15695	COG1185	polyribonucleotide nucleotidyltransferase activity
C4Q27_RS15700	COG2823	Periplasmic or secreted lipoprotein
C4Q27_RS15725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4Q27_RS15735	COG0166	Belongs to the GPI family
C4Q27_RS15740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4Q27_RS15745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4Q27_RS15770	COG4191	Histidine kinase
C4Q27_RS15780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4Q27_RS15790	COG0436	Aminotransferase
C4Q27_RS15795	COG1489	DNA binding
C4Q27_RS15805	COG4558	Periplasmic binding protein
C4Q27_RS15810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4Q27_RS15815	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4Q27_RS15835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4Q27_RS15845	COG3098	single-species biofilm formation
C4Q27_RS15850	COG0028	Belongs to the TPP enzyme family
C4Q27_RS15860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4Q27_RS15865	COG1183	phosphatidylcholine synthase activity
C4Q27_RS15870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C4Q27_RS15875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C4Q27_RS15915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4Q27_RS15920	COG1074	ATP-dependent DNA helicase activity
C4Q27_RS15925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4Q27_RS15935	COG2199	diguanylate cyclase activity
C4Q27_RS15940	COG3047	cAMP biosynthetic process
C4Q27_RS15940	COG2885	chlorophyll binding
C4Q27_RS15985	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4Q27_RS15990	COG0583	DNA-binding transcription factor activity
C4Q27_RS16000	COG0840	transmembrane signaling receptor activity
C4Q27_RS16005	COG2321	neutral zinc metallopeptidase
C4Q27_RS16010	COG3485	protocatechuate 3,4-dioxygenase
C4Q27_RS16015	COG3485	protocatechuate 3,4-dioxygenase
C4Q27_RS16020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4Q27_RS16025	COG2252	PERMEase
C4Q27_RS16035	COG1271	oxidase subunit
C4Q27_RS16040	COG1294	oxidase, subunit
C4Q27_RS16050	COG2813	Specifically methylates the guanine in position
C4Q27_RS16055	COG2197	response regulator
C4Q27_RS16065	COG1970	mechanosensitive ion channel activity
C4Q27_RS16075	COG2233	PERMEase
C4Q27_RS16085	COG1966	Carbon starvation protein
C4Q27_RS16090	COG2879	small protein
C4Q27_RS16095	COG0523	cobalamin synthesis protein
C4Q27_RS16105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4Q27_RS16120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4Q27_RS16150	COG0789	Transcriptional regulator
C4Q27_RS16160	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q27_RS16170	COG0583	DNA-binding transcription factor activity
C4Q27_RS16180	COG1346	cytolysis
C4Q27_RS16200	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C4Q27_RS16260	COG4772	TonB-dependent receptor
C4Q27_RS16265	COG3712	iron ion homeostasis
C4Q27_RS16270	COG1595	DNA-templated transcription, initiation
C4Q27_RS16305	COG2207	Transcriptional regulator
C4Q27_RS16305	COG3708	Transcriptional regulator
C4Q27_RS16315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q27_RS16320	COG0583	DNA-binding transcription factor activity
C4Q27_RS16340	COG1566	PFAM secretion protein HlyD family protein
C4Q27_RS16370	COG0300	oxidoreductase activity
C4Q27_RS16385	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C4Q27_RS16385	COG0662	Cupin 2, conserved barrel domain protein
C4Q27_RS16400	COG1696	Membrane protein involved in D-alanine export
C4Q27_RS16420	COG3420	alginic acid biosynthetic process
C4Q27_RS16430	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4Q27_RS16435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS16440	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS16445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C4Q27_RS16450	COG3022	response to hydroperoxide
C4Q27_RS16460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4Q27_RS16465	COG0315	cyclic pyranopterin monophosphate synthase activity
C4Q27_RS16470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4Q27_RS16485	COG0513	Belongs to the DEAD box helicase family
C4Q27_RS16490	COG0400	carboxylic ester hydrolase activity
C4Q27_RS16495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS16500	COG4597	amino acid ABC transporter
C4Q27_RS16505	COG0765	amino acid transport
C4Q27_RS16510	COG1126	abc transporter atp-binding protein
C4Q27_RS16515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4Q27_RS16525	COG0175	sulfate reduction
C4Q27_RS16555	COG1522	sequence-specific DNA binding
C4Q27_RS16575	COG0180	Tryptophanyl-tRNA synthetase
C4Q27_RS16580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4Q27_RS16590	COG0667	Aldo Keto reductase
C4Q27_RS16595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C4Q27_RS16600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4Q27_RS16605	COG0723	plastoquinol--plastocyanin reductase activity
C4Q27_RS16610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4Q27_RS16615	COG2857	Cytochrome c1
C4Q27_RS16620	COG0625	glutathione transferase activity
C4Q27_RS16625	COG2969	positive regulation of protein catabolic process
C4Q27_RS16630	COG2823	Periplasmic or secreted lipoprotein
C4Q27_RS16635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4Q27_RS16640	COG0792	nuclease activity
C4Q27_RS16645	COG3107	peptidoglycan biosynthetic process
C4Q27_RS16660	COG2001	Belongs to the MraZ family
C4Q27_RS16665	COG0275	rRNA processing
C4Q27_RS16680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4Q27_RS16685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4Q27_RS16690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4Q27_RS16695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4Q27_RS16700	COG0772	Belongs to the SEDS family
C4Q27_RS16705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4Q27_RS16710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4Q27_RS16715	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4Q27_RS16730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4Q27_RS16735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4Q27_RS16750	COG0653	protein targeting
C4Q27_RS16755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4Q27_RS16770	COG0494	nUDIX hydrolase
C4Q27_RS16780	COG2096	Adenosyltransferase
C4Q27_RS16795	COG1666	GTP binding
C4Q27_RS16800	COG0668	transmembrane transport
C4Q27_RS16835	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4Q27_RS16840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4Q27_RS16845	COG0459	protein refolding
C4Q27_RS16865	COG2925	Exonuclease
C4Q27_RS16875	COG0788	formyltetrahydrofolate deformylase activity
C4Q27_RS16895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4Q27_RS16895	COG0438	transferase activity, transferring glycosyl groups
C4Q27_RS16900	COG0840	transmembrane signaling receptor activity
C4Q27_RS16905	COG0433	COG0433 Predicted ATPase
C4Q27_RS16910	COG0306	phosphate transporter
C4Q27_RS16925	COG1414	Transcriptional regulator
C4Q27_RS16930	COG2814	Major facilitator Superfamily
C4Q27_RS16940	COG0183	Belongs to the thiolase family
C4Q27_RS16945	COG0477	Major facilitator Superfamily
C4Q27_RS16950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4Q27_RS16955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4Q27_RS16960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4Q27_RS16990	COG1309	transcriptional regulator
C4Q27_RS16995	COG0477	Major facilitator Superfamily
C4Q27_RS17000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4Q27_RS17005	COG0583	DNA-binding transcription factor activity
C4Q27_RS17010	COG2910	NAD(P)H-binding
C4Q27_RS17015	COG0583	DNA-binding transcription factor activity
C4Q27_RS17025	COG2207	Transcriptional regulator
C4Q27_RS17050	COG0477	Major facilitator Superfamily
C4Q27_RS17060	COG4191	Histidine kinase
C4Q27_RS17100	COG2267	carboxylic ester hydrolase activity
C4Q27_RS17130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C4Q27_RS17180	COG0354	folic acid binding
C4Q27_RS17185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4Q27_RS17215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4Q27_RS17220	COG0481	GTPase activity
C4Q27_RS17225	COG0681	Belongs to the peptidase S26 family
C4Q27_RS17230	COG0571	ribonuclease III activity
C4Q27_RS17235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4Q27_RS17245	COG1381	Involved in DNA repair and RecF pathway recombination
C4Q27_RS17250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4Q27_RS17255	COG0500	methyltransferase
C4Q27_RS17260	COG2226	methyltransferase
C4Q27_RS17270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4Q27_RS17290	COG4206	TonB-dependent receptor
C4Q27_RS17295	COG4628	conserved protein (DUF2132)
C4Q27_RS17325	COG0494	nUDIX hydrolase
C4Q27_RS17345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4Q27_RS17350	COG0477	Major facilitator Superfamily
C4Q27_RS17355	COG4536	flavin adenine dinucleotide binding
C4Q27_RS17365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4Q27_RS17370	COG0228	four-way junction DNA binding
C4Q27_RS17375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4Q27_RS17380	COG0336	Belongs to the RNA methyltransferase TrmD family
C4Q27_RS17385	COG0335	large ribosomal subunit rRNA binding
C4Q27_RS17390	COG1607	acyl-coa hydrolase
C4Q27_RS17400	COG4974	Belongs to the 'phage' integrase family
C4Q27_RS17435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4Q27_RS17480	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS17500	COG1177	transmembrane transport
C4Q27_RS17505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4Q27_RS17510	COG3842	ATPase activity
C4Q27_RS17515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4Q27_RS17520	COG2979	Protein of unknown function (DUF533)
C4Q27_RS17525	COG0840	transmembrane signaling receptor activity
C4Q27_RS17535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4Q27_RS17535	COG0457	Tetratricopeptide repeat
C4Q27_RS17550	COG2201	protein-glutamate methylesterase activity
C4Q27_RS17555	COG5001	Diguanylate cyclase
C4Q27_RS17555	COG4251	negative regulation of phosphorylation
C4Q27_RS17555	COG3706	GGDEF domain
C4Q27_RS17555	COG2203	Gaf domain
C4Q27_RS17565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4Q27_RS17590	COG1073	alpha beta
C4Q27_RS17600	COG2885	chlorophyll binding
C4Q27_RS17615	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C4Q27_RS17625	COG0563	adenylate kinase activity
C4Q27_RS17660	COG0742	ribosomal rna small subunit methyltransferase
C4Q27_RS17670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS17690	COG2937	Belongs to the GPAT DAPAT family
C4Q27_RS17705	COG2226	methyltransferase
C4Q27_RS17710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4Q27_RS17715	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS17720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4Q27_RS17735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4Q27_RS17740	COG2171	N-acyltransferase activity
C4Q27_RS17745	COG1393	Belongs to the ArsC family
C4Q27_RS17760	COG0025	NhaP-type Na H and K H
C4Q27_RS17770	COG0436	Aminotransferase
C4Q27_RS17775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C4Q27_RS17780	COG0024	Methionine aminopeptidase
C4Q27_RS17785	COG0052	Belongs to the universal ribosomal protein uS2 family
C4Q27_RS17790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4Q27_RS17795	COG0528	UMP kinase activity
C4Q27_RS17800	COG0233	cytoplasmic translational termination
C4Q27_RS17805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4Q27_RS17815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4Q27_RS17835	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4Q27_RS17840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4Q27_RS17845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4Q27_RS17850	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4Q27_RS17855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4Q27_RS17865	COG0825	malonyl-CoA metabolic process
C4Q27_RS17875	COG0037	tRNA processing
C4Q27_RS17880	COG0504	CTP synthase activity
C4Q27_RS17885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4Q27_RS17890	COG0148	phosphopyruvate hydratase activity
C4Q27_RS17900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4Q27_RS17920	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4Q27_RS17930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4Q27_RS17935	COG0585	pseudouridine synthase activity
C4Q27_RS17940	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4Q27_RS17945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4Q27_RS17960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4Q27_RS17965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C4Q27_RS17975	COG1546	Belongs to the CinA family
C4Q27_RS17980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4Q27_RS17985	COG2137	regulation of response to DNA damage stimulus
C4Q27_RS18010	COG3148	PFAM DTW domain containing protein
C4Q27_RS18025	COG0583	DNA-binding transcription factor activity
C4Q27_RS18035	COG3091	SprT-like family
C4Q27_RS18045	COG0037	tRNA processing
C4Q27_RS18095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q27_RS18100	COG2205	protein histidine kinase activity
C4Q27_RS18100	COG5002	protein histidine kinase activity
C4Q27_RS18100	COG0784	Response regulator, receiver
C4Q27_RS18120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4Q27_RS18125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4Q27_RS18130	COG3956	TIGRFAM MazG family protein
C4Q27_RS18135	COG3122	Protein conserved in bacteria
C4Q27_RS18165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4Q27_RS18170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4Q27_RS18185	COG0628	permease
C4Q27_RS18195	COG0791	NLP P60 protein
C4Q27_RS18200	COG0791	NLP P60 protein
C4Q27_RS18210	COG1797	cobyrinic acid a,c-diamide synthase activity
C4Q27_RS18215	COG0778	Nitroreductase
C4Q27_RS18230	COG1492	cobalamin metabolic process
C4Q27_RS18240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4Q27_RS18245	COG0406	alpha-ribazole phosphatase activity
C4Q27_RS18250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C4Q27_RS18280	COG0583	DNA-binding transcription factor activity
C4Q27_RS18320	COG2205	protein histidine kinase activity
C4Q27_RS18325	COG2814	Major facilitator Superfamily
C4Q27_RS18330	COG2188	Transcriptional regulator
C4Q27_RS18335	COG2814	Major facilitator Superfamily
C4Q27_RS18345	COG0477	Major facilitator Superfamily
C4Q27_RS18350	COG2076	Multidrug Resistance protein
C4Q27_RS18360	COG2974	May be involved in recombination
C4Q27_RS18390	COG0243	molybdopterin cofactor binding
C4Q27_RS18395	COG2146	nitrite reductase [NAD(P)H] activity
C4Q27_RS18395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4Q27_RS18400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4Q27_RS18400	COG2146	nitrite reductase [NAD(P)H] activity
C4Q27_RS18410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q27_RS18415	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS18420	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4Q27_RS18425	COG2271	Major facilitator Superfamily
C4Q27_RS18430	COG2169	Transcriptional regulator
C4Q27_RS18445	COG0583	DNA-binding transcription factor activity
C4Q27_RS18450	COG0545	Peptidyl-prolyl cis-trans isomerase
C4Q27_RS18455	COG3339	Conserved Protein
C4Q27_RS18475	COG5001	Diguanylate cyclase
C4Q27_RS18475	COG3300	MHYT domain
C4Q27_RS18505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4Q27_RS18525	COG0668	transmembrane transport
C4Q27_RS18530	COG1362	aminopeptidase activity
C4Q27_RS18535	COG0564	pseudouridine synthase activity
C4Q27_RS18540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C4Q27_RS18545	COG2894	cell division
C4Q27_RS18550	COG0850	regulation of cytokinetic process
C4Q27_RS18555	COG1560	Kdo2-lipid A biosynthetic process
C4Q27_RS18565	COG2853	Lipoprotein
C4Q27_RS18590	COG2113	Glycine betaine
C4Q27_RS18595	COG3162	membrane
C4Q27_RS18600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4Q27_RS18645	COG3089	Belongs to the UPF0270 family
C4Q27_RS18650	COG1363	Peptidase, m42
C4Q27_RS18655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4Q27_RS18655	COG0189	ligase activity
C4Q27_RS18660	COG0367	asparagine synthase
C4Q27_RS18665	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C4Q27_RS18665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS18670	COG2326	polyphosphate kinase activity
C4Q27_RS18675	COG0697	spore germination
C4Q27_RS18680	COG0114	fumarate hydratase activity
C4Q27_RS18690	COG0271	Belongs to the BolA IbaG family
C4Q27_RS18695	COG1054	Belongs to the UPF0176 family
C4Q27_RS18710	COG5001	Diguanylate cyclase
C4Q27_RS18710	COG5002	protein histidine kinase activity
C4Q27_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS18725	COG0546	phosphoglycolate phosphatase activity
C4Q27_RS18730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4Q27_RS18735	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4Q27_RS18750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4Q27_RS18760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4Q27_RS18765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4Q27_RS18780	COG0776	regulation of translation
C4Q27_RS18790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4Q27_RS18815	COG1086	Polysaccharide biosynthesis protein
C4Q27_RS18860	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4Q27_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS18880	COG3321	synthase
C4Q27_RS18880	COG0604	alcohol dehydrogenase
C4Q27_RS18885	COG0156	8-amino-7-oxononanoate synthase activity
C4Q27_RS18915	COG0300	oxidoreductase activity
C4Q27_RS18935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4Q27_RS18935	COG0517	IMP dehydrogenase activity
C4Q27_RS18950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4Q27_RS19010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4Q27_RS19015	COG1555	photosystem II stabilization
C4Q27_RS19025	COG0284	orotidine-5'-phosphate decarboxylase activity
C4Q27_RS19035	COG2130	NADP-dependent
C4Q27_RS19050	COG0840	transmembrane signaling receptor activity
C4Q27_RS19055	COG3135	benzoate transporter
C4Q27_RS19060	COG0625	glutathione transferase activity
C4Q27_RS19085	COG0302	gtp cyclohydrolase
C4Q27_RS19090	COG2840	Smr protein MutS2
C4Q27_RS19120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4Q27_RS19125	COG2814	Major facilitator Superfamily
C4Q27_RS19130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4Q27_RS19165	COG1368	sulfuric ester hydrolase activity
C4Q27_RS19185	COG0519	Catalyzes the synthesis of GMP from XMP
C4Q27_RS19190	COG0598	Magnesium transport protein CorA
C4Q27_RS19215	COG4773	Receptor
C4Q27_RS19230	COG2814	Major facilitator Superfamily
C4Q27_RS19235	COG0583	DNA-binding transcription factor activity
C4Q27_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS19245	COG0583	DNA-binding transcription factor activity
C4Q27_RS19265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4Q27_RS19275	COG1764	response to oxidative stress
C4Q27_RS19280	COG1846	Transcriptional regulator
C4Q27_RS19285	COG0583	DNA-binding transcription factor activity
C4Q27_RS19295	COG0583	DNA-binding transcription factor activity
C4Q27_RS19310	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C4Q27_RS19325	COG3384	dioxygenase
C4Q27_RS19330	COG0500	methyltransferase
C4Q27_RS19335	COG0501	Belongs to the peptidase M48B family
C4Q27_RS19350	COG0436	Aminotransferase
C4Q27_RS19355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4Q27_RS19360	COG0386	Belongs to the glutathione peroxidase family
C4Q27_RS19365	COG5002	protein histidine kinase activity
C4Q27_RS19365	COG2205	protein histidine kinase activity
C4Q27_RS19365	COG0784	Response regulator, receiver
C4Q27_RS19375	COG1956	GAF domain-containing protein
C4Q27_RS19475	COG3121	Chaperone
C4Q27_RS19500	COG0625	glutathione transferase activity
C4Q27_RS19505	COG1131	(ABC) transporter
C4Q27_RS19510	COG0842	Transport permease protein
C4Q27_RS19525	COG0811	peptide transport
C4Q27_RS19530	COG0848	biopolymer transport protein
C4Q27_RS19535	COG1663	tetraacyldisaccharide 4'-kinase activity
C4Q27_RS19540	COG2835	tetraacyldisaccharide 4'-kinase activity
C4Q27_RS19545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4Q27_RS19550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4Q27_RS19555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4Q27_RS19560	COG1530	ribonuclease E activity
C4Q27_RS19575	COG0546	phosphoglycolate phosphatase activity
C4Q27_RS19580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4Q27_RS19580	COG0616	signal peptide processing
C4Q27_RS19585	COG0424	maF-like protein
C4Q27_RS19595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4Q27_RS19600	COG0416	fatty acid biosynthetic process
C4Q27_RS19615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4Q27_RS19620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4Q27_RS19630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4Q27_RS19635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4Q27_RS19645	COG0084	hydrolase, TatD family'
C4Q27_RS19700	COG0556	nucleotide-excision repair
C4Q27_RS19720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4Q27_RS19760	COG0596	Alpha beta hydrolase
C4Q27_RS19770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4Q27_RS19800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4Q27_RS19805	COG0066	3-isopropylmalate dehydratase activity
C4Q27_RS19810	COG2226	methyltransferase
C4Q27_RS19815	COG0473	3-isopropylmalate dehydrogenase activity
C4Q27_RS19840	COG0135	phosphoribosylanthranilate isomerase activity
C4Q27_RS19845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4Q27_RS19850	COG0285	dihydrofolate synthase activity
C4Q27_RS19860	COG1286	toxin biosynthetic process
C4Q27_RS19925	COG3121	Chaperone
C4Q27_RS19935	COG2197	response regulator
C4Q27_RS19940	COG2205	protein histidine kinase activity
C4Q27_RS19940	COG0784	Response regulator, receiver
C4Q27_RS19945	COG2199	diguanylate cyclase activity
C4Q27_RS19945	COG2202	Pas domain
C4Q27_RS19945	COG2200	EAL domain
C4Q27_RS19950	COG2205	protein histidine kinase activity
C4Q27_RS19950	COG0784	Response regulator, receiver
C4Q27_RS19970	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS19980	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS20000	COG4221	oxidoreductase activity
C4Q27_RS20005	COG0604	alcohol dehydrogenase
C4Q27_RS20015	COG2207	Transcriptional regulator
C4Q27_RS20020	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS20020	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4Q27_RS20035	COG3038	cytochrome b561
C4Q27_RS20045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4Q27_RS20050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4Q27_RS20055	COG0705	Rhomboid family
C4Q27_RS20060	COG3139	Protein of unknown function (DUF1315)
C4Q27_RS20070	COG0308	aminopeptidase N
C4Q27_RS20090	COG2706	6-phosphogluconolactonase activity
C4Q27_RS20125	COG0420	3'-5' exonuclease activity
C4Q27_RS20155	COG0714	Associated with various cellular activities
C4Q27_RS20170	COG3135	benzoate transporter
C4Q27_RS20175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4Q27_RS20185	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS20190	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS20215	COG2149	membrane
C4Q27_RS20225	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C4Q27_RS20235	COG1024	Enoyl-CoA hydratase
C4Q27_RS20235	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4Q27_RS20240	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS20245	COG1454	alcohol dehydrogenase
C4Q27_RS20255	COG0183	Belongs to the thiolase family
C4Q27_RS20260	COG0246	Mannitol dehydrogenase
C4Q27_RS20270	COG0583	DNA-binding transcription factor activity
C4Q27_RS20275	COG2828	Protein conserved in bacteria
C4Q27_RS20280	COG1301	dicarboxylic acid transport
C4Q27_RS20285	COG2851	Citrate transporter
C4Q27_RS20295	COG3237	CsbD-like
C4Q27_RS20300	COG0789	Transcriptional regulator
C4Q27_RS20310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q27_RS20315	COG2188	Transcriptional regulator
C4Q27_RS20375	COG2826	transposase and inactivated derivatives, IS30 family
C4Q27_RS20395	COG1595	DNA-templated transcription, initiation
C4Q27_RS20400	COG0019	diaminopimelate decarboxylase activity
C4Q27_RS20405	COG0583	DNA-binding transcription factor activity
C4Q27_RS20430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C4Q27_RS20445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4Q27_RS20460	COG0668	transmembrane transport
C4Q27_RS20485	COG2223	nitrite transmembrane transporter activity
C4Q27_RS20490	COG3707	response regulator
C4Q27_RS20495	COG1116	anion transmembrane transporter activity
C4Q27_RS20495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS20500	COG0167	dihydroorotate dehydrogenase activity
C4Q27_RS20505	COG3130	regulation of translation
C4Q27_RS20510	COG0116	Belongs to the methyltransferase superfamily
C4Q27_RS20510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C4Q27_RS20520	COG2027	D-alanyl-D-alanine carboxypeptidase
C4Q27_RS20525	COG3171	Protein conserved in bacteria
C4Q27_RS20530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS20530	COG2205	protein histidine kinase activity
C4Q27_RS20535	COG2197	response regulator
C4Q27_RS20560	COG0004	ammonium transporteR
C4Q27_RS20595	COG0840	transmembrane signaling receptor activity
C4Q27_RS20605	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C4Q27_RS20620	COG0425	Belongs to the sulfur carrier protein TusA family
C4Q27_RS20625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4Q27_RS20630	COG1132	(ABC) transporter
C4Q27_RS20650	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4Q27_RS20660	COG0438	transferase activity, transferring glycosyl groups
C4Q27_RS20665	COG1597	lipid kinase activity
C4Q27_RS20670	COG2197	response regulator
C4Q27_RS20675	COG3851	Histidine kinase
C4Q27_RS20685	COG0835	chemotaxis
C4Q27_RS20685	COG0784	Response regulator, receiver
C4Q27_RS20690	COG0633	Ferredoxin
C4Q27_RS20690	COG3217	Mosc domain protein beta barrel domain protein
C4Q27_RS20700	COG0741	lytic transglycosylase activity
C4Q27_RS20705	COG0488	(ABC) transporter
C4Q27_RS20710	COG0589	response to stress
C4Q27_RS20725	COG1024	Enoyl-CoA hydratase
C4Q27_RS20725	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4Q27_RS20730	COG0183	Belongs to the thiolase family
C4Q27_RS20760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4Q27_RS20775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4Q27_RS20785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4Q27_RS20795	COG1477	protein flavinylation
C4Q27_RS20800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4Q27_RS20805	COG0584	glycerophosphoryl diester phosphodiesterase
C4Q27_RS20815	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4Q27_RS20820	COG1136	(ABC) transporter
C4Q27_RS20825	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4Q27_RS20845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4Q27_RS20845	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4Q27_RS20860	COG2853	Lipoprotein
C4Q27_RS20870	COG4566	intracellular signal transduction
C4Q27_RS20890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4Q27_RS20895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4Q27_RS20940	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS20945	COG0583	DNA-binding transcription factor activity
C4Q27_RS20955	COG0174	glutamine synthetase
C4Q27_RS20960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4Q27_RS20990	COG3383	formate dehydrogenase (NAD+) activity
C4Q27_RS21000	COG0589	response to stress
C4Q27_RS21025	COG1595	DNA-templated transcription, initiation
C4Q27_RS21050	COG0010	Belongs to the arginase family
C4Q27_RS21060	COG2133	pyrroloquinoline quinone binding
C4Q27_RS21065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4Q27_RS21075	COG0596	Alpha beta hydrolase
C4Q27_RS21080	COG1238	metal cluster binding
C4Q27_RS21095	COG2132	Multicopper oxidase
C4Q27_RS21100	COG0826	peptidase U32
C4Q27_RS21125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4Q27_RS21130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4Q27_RS21135	COG0583	DNA-binding transcription factor activity
C4Q27_RS21140	COG2207	Transcriptional regulator
C4Q27_RS21150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4Q27_RS21160	COG0183	Belongs to the thiolase family
C4Q27_RS21165	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS21170	COG1024	Enoyl-CoA hydratase
C4Q27_RS21200	COG1320	monovalent cation:proton antiporter activity
C4Q27_RS21205	COG2212	antiporter activity
C4Q27_RS21215	COG0651	ATP synthesis coupled electron transport
C4Q27_RS21220	COG1006	Multisubunit Na H antiporter MnhC subunit
C4Q27_RS21225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4Q27_RS21225	COG2111	Na H antiporter
C4Q27_RS21240	COG1335	isochorismatase
C4Q27_RS21325	COG0730	response to heat
C4Q27_RS21340	COG0251	oxidation-reduction process
C4Q27_RS21345	COG3949	Membrane
C4Q27_RS21350	COG0840	transmembrane signaling receptor activity
C4Q27_RS21355	COG0583	DNA-binding transcription factor activity
C4Q27_RS21375	COG2186	Transcriptional regulator
C4Q27_RS21390	COG0840	transmembrane signaling receptor activity
C4Q27_RS21400	COG3284	Transcriptional regulator
C4Q27_RS21405	COG3842	ATPase activity
C4Q27_RS21410	COG3842	ATPase activity
C4Q27_RS21420	COG0395	ABC-type sugar transport system, permease component
C4Q27_RS21435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4Q27_RS21465	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4Q27_RS21470	COG0740	serine-type endopeptidase activity
C4Q27_RS21475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C4Q27_RS21480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4Q27_RS21490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4Q27_RS21530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4Q27_RS21535	COG2259	Doxx family
C4Q27_RS21545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4Q27_RS21550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4Q27_RS21555	COG4181	ATPase activity
C4Q27_RS21570	COG1388	LysM domain
C4Q27_RS21570	COG1376	ErfK ybiS ycfS ynhG family protein
C4Q27_RS21585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4Q27_RS21590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4Q27_RS21595	COG0589	response to stress
C4Q27_RS21630	COG4067	protein conserved in archaea
C4Q27_RS21630	COG0189	ligase activity
C4Q27_RS21635	COG1802	Transcriptional regulator
C4Q27_RS21645	COG0372	Belongs to the citrate synthase family
C4Q27_RS21660	COG2079	MmgE PrpD family protein
C4Q27_RS21675	COG0720	synthase
C4Q27_RS21705	COG0517	IMP dehydrogenase activity
C4Q27_RS21705	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C4Q27_RS21705	COG0617	tRNA 3'-terminal CCA addition
C4Q27_RS21720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4Q27_RS21745	COG4251	negative regulation of phosphorylation
C4Q27_RS21785	COG2866	Carboxypeptidase
C4Q27_RS21790	COG2207	Transcriptional regulator
C4Q27_RS21795	COG2223	nitrite transmembrane transporter activity
C4Q27_RS21800	COG2814	Major facilitator Superfamily
C4Q27_RS21865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C4Q27_RS21870	COG0316	Belongs to the HesB IscA family
C4Q27_RS21870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C4Q27_RS21875	COG1999	signal sequence binding
C4Q27_RS21925	COG0583	DNA-binding transcription factor activity
C4Q27_RS21930	COG0583	DNA-binding transcription factor activity
C4Q27_RS21935	COG2814	Major facilitator Superfamily
C4Q27_RS21940	COG0417	DNA replication proofreading
C4Q27_RS21965	COG3220	belongs to the UPF0276 family
C4Q27_RS21975	COG2259	Doxx family
C4Q27_RS22005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4Q27_RS22010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4Q27_RS22015	COG0477	Major facilitator Superfamily
C4Q27_RS22020	COG1192	Involved in chromosome partitioning
C4Q27_RS22045	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C4Q27_RS22050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4Q27_RS22065	COG4774	siderophore transport
C4Q27_RS22075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4Q27_RS22105	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4Q27_RS22115	COG2207	Transcriptional regulator
C4Q27_RS22120	COG1064	alcohol dehydrogenase
C4Q27_RS22130	COG2814	Major facilitator Superfamily
C4Q27_RS22145	COG0583	DNA-binding transcription factor activity
C4Q27_RS22155	COG5642	Protein of unknown function (DUF2384)
C4Q27_RS22160	COG5654	RES domain protein
C4Q27_RS22165	COG1104	cysteine desulfurase activity
C4Q27_RS22190	COG0861	Integral membrane protein TerC family
C4Q27_RS22200	COG3634	alkyl hydroperoxide reductase activity
C4Q27_RS22220	COG3132	Protein of unknown function, DUF480
C4Q27_RS22225	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4Q27_RS22230	COG0583	DNA-binding transcription factor activity
C4Q27_RS22240	COG1253	flavin adenine dinucleotide binding
C4Q27_RS22255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS22275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4Q27_RS22290	COG2116	formate transmembrane transporter activity
C4Q27_RS22295	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4Q27_RS22300	COG3604	Transcriptional regulator
C4Q27_RS22305	COG0252	asparaginase activity
C4Q27_RS22310	COG1879	ABC-type sugar transport system periplasmic component
C4Q27_RS22315	COG1129	ABC transporter
C4Q27_RS22320	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4Q27_RS22325	COG1609	Transcriptional regulator
C4Q27_RS22330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4Q27_RS22335	COG1869	D-ribose catabolic process
C4Q27_RS22355	COG1278	Cold shock
C4Q27_RS22365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4Q27_RS22370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4Q27_RS22375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4Q27_RS22380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4Q27_RS22385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4Q27_RS22390	COG0072	phenylalanine-tRNA ligase activity
C4Q27_RS22395	COG0776	regulation of translation
C4Q27_RS22440	COG3344	reverse transcriptase
C4Q27_RS22600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4Q27_RS22645	COG1192	Involved in chromosome partitioning
C4Q27_RS22665	COG1024	Enoyl-CoA hydratase
C4Q27_RS22670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4Q27_RS22690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4Q27_RS22705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4Q27_RS22725	COG2271	Major facilitator Superfamily
C4Q27_RS22730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q27_RS22735	COG4948	Mandelate Racemase Muconate Lactonizing
C4Q27_RS22755	COG1609	Transcriptional regulator
C4Q27_RS22760	COG2271	Major facilitator Superfamily
C4Q27_RS22770	COG2721	sulfolactate sulfo-lyase activity
C4Q27_RS22795	COG1609	Transcriptional regulator
C4Q27_RS22800	COG4948	Mandelate Racemase Muconate Lactonizing
C4Q27_RS22805	COG2271	Major facilitator Superfamily
C4Q27_RS22830	COG1609	Transcriptional regulator
C4Q27_RS22835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4Q27_RS22900	COG2010	Cytochrome c
C4Q27_RS22930	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS22945	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS22950	COG0492	ferredoxin-NADP+ reductase activity
C4Q27_RS22965	COG2124	cytochrome p450
C4Q27_RS22970	COG1141	Ferredoxin
C4Q27_RS22985	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS23015	COG2826	transposase and inactivated derivatives, IS30 family
C4Q27_RS23040	COG2826	transposase and inactivated derivatives, IS30 family
C4Q27_RS23045	COG0583	DNA-binding transcription factor activity
C4Q27_RS23075	COG1942	4-Oxalocrotonate Tautomerase
C4Q27_RS23125	COG0302	gtp cyclohydrolase
C4Q27_RS23135	COG2066	Belongs to the glutaminase family
C4Q27_RS23145	COG1418	mRNA catabolic process
C4Q27_RS23165	COG2873	o-acetylhomoserine
C4Q27_RS23180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4Q27_RS23185	COG0583	DNA-binding transcription factor activity
C4Q27_RS23190	COG2814	Major facilitator Superfamily
C4Q27_RS23195	COG0625	glutathione transferase activity
C4Q27_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS23225	COG0583	DNA-binding transcription factor activity
C4Q27_RS23230	COG0477	Major facilitator Superfamily
C4Q27_RS23245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS23260	COG4106	trans-aconitate 2-methyltransferase activity
C4Q27_RS23270	COG0583	DNA-binding transcription factor activity
C4Q27_RS23280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS23285	COG0217	transcriptional regulatory protein
C4Q27_RS23290	COG0583	DNA-binding transcription factor activity
C4Q27_RS23295	COG0076	glutamate decarboxylase activity
C4Q27_RS23305	COG1082	Xylose isomerase domain protein TIM barrel
C4Q27_RS23305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C4Q27_RS23310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4Q27_RS23370	COG0210	DNA helicase
C4Q27_RS23380	COG0596	Alpha beta hydrolase
C4Q27_RS23390	COG0477	Major facilitator Superfamily
C4Q27_RS23405	COG0346	lactoylglutathione lyase activity
C4Q27_RS23425	COG2995	paraquat-inducible protein a
C4Q27_RS23430	COG3008	intermembrane lipid transfer
C4Q27_RS23440	COG2194	sulfuric ester hydrolase activity
C4Q27_RS23470	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS23475	COG0531	amino acid
C4Q27_RS23480	COG2197	response regulator
C4Q27_RS23490	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS23495	COG4774	siderophore transport
C4Q27_RS23500	COG4607	ABC-type enterochelin transport system periplasmic component
C4Q27_RS23505	COG4604	ABC transporter, ATP-binding protein
C4Q27_RS23510	COG4605	iron ion homeostasis
C4Q27_RS23515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4Q27_RS23520	COG1132	(ABC) transporter
C4Q27_RS23525	COG1132	(ABC) transporter
C4Q27_RS23525	COG2375	cellular response to nickel ion
C4Q27_RS23535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C4Q27_RS23540	COG1053	succinate dehydrogenase
C4Q27_RS23550	COG0673	inositol 2-dehydrogenase activity
C4Q27_RS23565	COG1053	succinate dehydrogenase
C4Q27_RS23575	COG1053	succinate dehydrogenase
C4Q27_RS23580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4Q27_RS23585	COG1414	Transcriptional regulator
C4Q27_RS23680	COG1132	(ABC) transporter
C4Q27_RS23695	COG2194	sulfuric ester hydrolase activity
C4Q27_RS23710	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS23715	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS23720	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C4Q27_RS23725	COG3118	belongs to the thioredoxin family
C4Q27_RS23725	COG0457	Tetratricopeptide repeat
C4Q27_RS23730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4Q27_RS23735	COG0454	-acetyltransferase
C4Q27_RS23795	COG2271	Major facilitator Superfamily
C4Q27_RS23825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4Q27_RS23835	COG0581	inorganic phosphate transmembrane transporter activity
C4Q27_RS23840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4Q27_RS23870	COG2205	protein histidine kinase activity
C4Q27_RS23870	COG0784	Response regulator, receiver
C4Q27_RS23890	COG1131	(ABC) transporter
C4Q27_RS23970	COG0642	Histidine kinase
C4Q27_RS23980	COG3048	D-serine ammonia-lyase activity
C4Q27_RS23990	COG1305	Transglutaminase-like
C4Q27_RS24000	COG2308	Evidence 4 Homologs of previously reported genes of
C4Q27_RS24020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4Q27_RS24030	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS24040	COG0583	DNA-binding transcription factor activity
C4Q27_RS24045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4Q27_RS24060	COG0678	peroxiredoxin activity
C4Q27_RS24060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4Q27_RS24065	COG0583	DNA-binding transcription factor activity
C4Q27_RS24080	COG1473	amidohydrolase
C4Q27_RS24105	COG0708	Exodeoxyribonuclease III
C4Q27_RS24145	COG0431	NADPH-dependent FMN reductase
C4Q27_RS24150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4Q27_RS24155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4Q27_RS24160	COG0640	Transcriptional regulator
C4Q27_RS24175	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS24195	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS24205	COG0693	protein deglycase activity
C4Q27_RS24210	COG2323	membrane
C4Q27_RS24240	COG3046	protein related to deoxyribodipyrimidine photolyase
C4Q27_RS24255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4Q27_RS24270	COG4221	oxidoreductase activity
C4Q27_RS24280	COG1366	Belongs to the anti-sigma-factor antagonist family
C4Q27_RS24285	COG0789	Transcriptional regulator
C4Q27_RS24290	COG0668	transmembrane transport
C4Q27_RS24310	COG0589	response to stress
C4Q27_RS24380	COG1129	ABC transporter
C4Q27_RS24385	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4Q27_RS24390	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4Q27_RS24395	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS24400	COG0431	NADPH-dependent FMN reductase
C4Q27_RS24425	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4Q27_RS24435	COG3829	transcription factor binding
C4Q27_RS24460	COG0604	alcohol dehydrogenase
C4Q27_RS24465	COG1309	transcriptional regulator
C4Q27_RS24475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4Q27_RS24480	COG1454	alcohol dehydrogenase
C4Q27_RS24525	COG2851	Citrate transporter
C4Q27_RS24530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4Q27_RS24535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4Q27_RS24545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4Q27_RS24590	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4Q27_RS24605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4Q27_RS24625	COG3321	synthase
C4Q27_RS24625	COG0604	alcohol dehydrogenase
C4Q27_RS24625	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS24650	COG4948	Mandelate Racemase Muconate Lactonizing
C4Q27_RS24670	COG0583	DNA-binding transcription factor activity
C4Q27_RS24675	COG2721	sulfolactate sulfo-lyase activity
C4Q27_RS24690	COG2271	Major facilitator Superfamily
C4Q27_RS24700	COG1199	ATP-dependent helicase activity
C4Q27_RS24700	COG1199	ATP-dependent helicase activity
C4Q27_RS24705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4Q27_RS24710	COG0829	nickel cation binding
C4Q27_RS24715	COG0831	urea catabolic process
C4Q27_RS24720	COG0832	Belongs to the urease beta subunit family
C4Q27_RS24725	COG0804	urea catabolic process
C4Q27_RS24730	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4Q27_RS24740	COG0830	nickel cation binding
C4Q27_RS24745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4Q27_RS24825	COG0840	transmembrane signaling receptor activity
C4Q27_RS24830	COG1968	undecaprenyl-diphosphatase activity
C4Q27_RS24850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4Q27_RS24855	COG1252	NADH dehydrogenase
C4Q27_RS24865	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4Q27_RS24865	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS24875	COG0235	Class ii aldolase
C4Q27_RS24885	COG0393	Putative heavy-metal-binding
C4Q27_RS24930	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS24945	COG1396	sequence-specific DNA binding
C4Q27_RS24945	COG1917	Cupin 2, conserved barrel domain protein
C4Q27_RS24950	COG0477	Major facilitator Superfamily
C4Q27_RS24955	COG3038	cytochrome b561
C4Q27_RS24965	COG1595	DNA-templated transcription, initiation
C4Q27_RS24975	COG0708	Exodeoxyribonuclease III
C4Q27_RS24985	COG0729	surface antigen
C4Q27_RS25025	COG2366	antibiotic biosynthetic process
C4Q27_RS25030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4Q27_RS25040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4Q27_RS25045	COG0215	cysteine-tRNA ligase activity
C4Q27_RS25055	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS25060	COG1802	Transcriptional regulator
C4Q27_RS25070	COG0579	oxidoreductase
C4Q27_RS25075	COG1113	amino acid transport
C4Q27_RS25085	COG0113	porphobilinogen synthase activity
C4Q27_RS25100	COG0307	riboflavin synthase, alpha
C4Q27_RS25115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C4Q27_RS25125	COG1984	allophanate hydrolase subunit 2
C4Q27_RS25140	COG0579	oxidoreductase
C4Q27_RS25150	COG4106	trans-aconitate 2-methyltransferase activity
C4Q27_RS25160	COG0019	diaminopimelate decarboxylase activity
C4Q27_RS25180	COG0625	glutathione transferase activity
C4Q27_RS25195	COG0488	(ABC) transporter
C4Q27_RS25255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4Q27_RS25270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4Q27_RS25305	COG2135	peptidase activity
C4Q27_RS25315	COG1858	cytochrome C peroxidase
C4Q27_RS25340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS25345	COG0697	spore germination
C4Q27_RS25400	COG0583	DNA-binding transcription factor activity
C4Q27_RS25420	COG0189	ligase activity
C4Q27_RS25445	COG0583	DNA-binding transcription factor activity
C4Q27_RS25460	COG0456	acetyltransferase
C4Q27_RS25460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C4Q27_RS25490	COG0604	alcohol dehydrogenase
C4Q27_RS25495	COG4221	oxidoreductase activity
C4Q27_RS25500	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS25520	COG1902	pentaerythritol trinitrate reductase activity
C4Q27_RS25520	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4Q27_RS25555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4Q27_RS25560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4Q27_RS25565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4Q27_RS25625	COG2175	clavaminate synthase activity
C4Q27_RS25630	COG3246	L-lysine catabolic process to acetate
C4Q27_RS25635	COG2814	Major facilitator Superfamily
C4Q27_RS25680	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS25685	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS25695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4Q27_RS25710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4Q27_RS25735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4Q27_RS25740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4Q27_RS25745	COG4574	serine-type endopeptidase inhibitor activity
C4Q27_RS25750	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS25755	COG2610	gluconate transmembrane transporter activity
C4Q27_RS25760	COG3829	transcription factor binding
C4Q27_RS25760	COG3290	protein histidine kinase activity
C4Q27_RS25765	COG4239	(ABC) transporter, permease
C4Q27_RS25770	COG4174	ABC transporter (Permease)
C4Q27_RS25780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4Q27_RS25785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4Q27_RS25790	COG1881	PFAM PEBP family protein
C4Q27_RS25815	COG3712	iron ion homeostasis
C4Q27_RS25820	COG1595	DNA-templated transcription, initiation
C4Q27_RS25840	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS25845	COG1053	succinate dehydrogenase
C4Q27_RS25860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4Q27_RS25865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4Q27_RS25880	COG0587	DNA-directed DNA polymerase activity
C4Q27_RS25890	COG0656	L-ascorbic acid biosynthetic process
C4Q27_RS25900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4Q27_RS25910	COG2031	fatty acid transporter
C4Q27_RS25915	COG1396	sequence-specific DNA binding
C4Q27_RS25940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4Q27_RS25985	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS25990	COG2990	Protein conserved in bacteria
C4Q27_RS26000	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS26015	COG0583	DNA-binding transcription factor activity
C4Q27_RS26020	COG1760	l-serine dehydratase
C4Q27_RS26030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS26040	COG0174	glutamine synthetase
C4Q27_RS26055	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS26060	COG0583	DNA-binding transcription factor activity
C4Q27_RS26125	COG2814	Major facilitator Superfamily
C4Q27_RS26130	COG3485	protocatechuate 3,4-dioxygenase
C4Q27_RS26135	COG3135	benzoate transporter
C4Q27_RS26155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS26165	COG0667	Aldo Keto reductase
C4Q27_RS26170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4Q27_RS26175	COG2271	Major facilitator Superfamily
C4Q27_RS26180	COG3835	regulator
C4Q27_RS26185	COG1929	Belongs to the glycerate kinase type-1 family
C4Q27_RS26190	COG0583	DNA-binding transcription factor activity
C4Q27_RS26210	COG1999	signal sequence binding
C4Q27_RS26225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C4Q27_RS26230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4Q27_RS26240	COG0402	S-adenosylhomocysteine deaminase activity
C4Q27_RS26245	COG2423	ornithine cyclodeaminase activity
C4Q27_RS26250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4Q27_RS26270	COG1228	amidohydrolase
C4Q27_RS26295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4Q27_RS26335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4Q27_RS26340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C4Q27_RS26355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4Q27_RS26370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS26395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS26400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS26410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4Q27_RS26415	COG0601	transmembrane transport
C4Q27_RS26420	COG0747	negative chemotaxis
C4Q27_RS26425	COG0235	Class ii aldolase
C4Q27_RS26430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4Q27_RS26435	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS26440	COG0583	DNA-binding transcription factor activity
C4Q27_RS26445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS26450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS26505	COG0589	response to stress
C4Q27_RS26530	COG4251	negative regulation of phosphorylation
C4Q27_RS26530	COG2203	Gaf domain
C4Q27_RS26530	COG3706	GGDEF domain
C4Q27_RS26530	COG5001	Diguanylate cyclase
C4Q27_RS26540	COG1285	pathogenesis
C4Q27_RS26550	COG0385	Bile acid
C4Q27_RS26555	COG2837	iron assimilation
C4Q27_RS26560	COG0667	Aldo Keto reductase
C4Q27_RS26585	COG2890	protein-(glutamine-N5) methyltransferase activity
C4Q27_RS26590	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C4Q27_RS26645	COG0392	lysyltransferase activity
C4Q27_RS26650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4Q27_RS26655	COG3568	Endonuclease Exonuclease Phosphatase
C4Q27_RS26670	COG0494	nUDIX hydrolase
C4Q27_RS26685	COG2030	dehydratase
C4Q27_RS26685	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS26700	COG3162	membrane
C4Q27_RS26705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4Q27_RS26710	COG2151	metal-sulfur cluster biosynthetic enzyme
C4Q27_RS26715	COG3396	Phenylacetate-CoA oxygenase
C4Q27_RS26720	COG3460	Phenylacetate-CoA oxygenase
C4Q27_RS26725	COG3396	Phenylacetate-CoA oxygenase
C4Q27_RS26735	COG0183	Belongs to the thiolase family
C4Q27_RS26740	COG2050	protein possibly involved in aromatic compounds catabolism
C4Q27_RS26745	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4Q27_RS26750	COG1024	Enoyl-CoA hydratase
C4Q27_RS26755	COG1024	Enoyl-CoA hydratase
C4Q27_RS26765	COG3327	negative regulation of DNA-templated transcription, initiation
C4Q27_RS26770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4Q27_RS26795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C4Q27_RS26840	COG1653	transport
C4Q27_RS26855	COG3842	ATPase activity
C4Q27_RS26860	COG1621	beta-fructofuranosidase activity
C4Q27_RS26870	COG1546	Belongs to the CinA family
C4Q27_RS26870	COG1058	Belongs to the CinA family
C4Q27_RS26875	COG1414	Transcriptional regulator
C4Q27_RS26880	COG2814	Major facilitator Superfamily
C4Q27_RS26885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4Q27_RS26890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4Q27_RS26905	COG0439	Biotin carboxylase
C4Q27_RS26910	COG3665	Urea carboxylase-associated protein
C4Q27_RS26955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4Q27_RS26960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4Q27_RS26965	COG2814	Major facilitator Superfamily
C4Q27_RS26970	COG0861	Integral membrane protein TerC family
C4Q27_RS26985	COG2080	2 iron, 2 sulfur cluster binding
C4Q27_RS26990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4Q27_RS26995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4Q27_RS27000	COG0475	glutathione-regulated potassium exporter activity
C4Q27_RS27000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4Q27_RS27005	COG0071	Belongs to the small heat shock protein (HSP20) family
C4Q27_RS27025	COG0542	response to heat
C4Q27_RS27045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C4Q27_RS27050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4Q27_RS27060	COG0113	porphobilinogen synthase activity
C4Q27_RS27065	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4Q27_RS27070	COG0735	belongs to the Fur family
C4Q27_RS27080	COG1469	GTP cyclohydrolase I activity
C4Q27_RS27095	COG1301	dicarboxylic acid transport
C4Q27_RS27150	COG0864	Transcriptional regulator
C4Q27_RS27155	COG0747	negative chemotaxis
C4Q27_RS27160	COG0601	transmembrane transport
C4Q27_RS27165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4Q27_RS27170	COG0444	Belongs to the ABC transporter superfamily
C4Q27_RS27175	COG1124	(ABC) transporter
C4Q27_RS27185	COG3706	GGDEF domain
C4Q27_RS27190	COG2814	Major facilitator Superfamily
C4Q27_RS27205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4Q27_RS27215	COG0183	Belongs to the thiolase family
C4Q27_RS27220	COG1022	Amp-dependent synthetase and ligase
C4Q27_RS27225	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS27230	COG1024	Enoyl-CoA hydratase
C4Q27_RS27240	COG0668	transmembrane transport
C4Q27_RS27245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4Q27_RS27255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4Q27_RS27280	COG2814	Major facilitator Superfamily
C4Q27_RS27290	COG0667	Aldo Keto reductase
C4Q27_RS27295	COG2205	protein histidine kinase activity
C4Q27_RS27300	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS27305	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4Q27_RS27315	COG2356	endonuclease I
C4Q27_RS27325	COG2271	Major facilitator Superfamily
C4Q27_RS27330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4Q27_RS27340	COG1609	Transcriptional regulator
C4Q27_RS27395	COG2271	Major facilitator Superfamily
C4Q27_RS27410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4Q27_RS27500	COG3813	Protein conserved in bacteria
C4Q27_RS27505	COG2197	response regulator
C4Q27_RS27510	COG2205	protein histidine kinase activity
C4Q27_RS27510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4Q27_RS27525	COG1609	Transcriptional regulator
C4Q27_RS27530	COG3265	gluconokinase activity
C4Q27_RS27545	COG2204	response regulator
C4Q27_RS27550	COG2205	protein histidine kinase activity
C4Q27_RS27560	COG5002	protein histidine kinase activity
C4Q27_RS27565	COG1196	nuclear chromosome segregation
C4Q27_RS27565	COG0741	lytic transglycosylase activity
C4Q27_RS27565	COG0739	heme binding
C4Q27_RS27575	COG1459	type II secretion system
C4Q27_RS27580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS27605	COG0784	Response regulator, receiver
C4Q27_RS27605	COG4191	Histidine kinase
C4Q27_RS27625	COG2200	EAL domain
C4Q27_RS27635	COG1253	flavin adenine dinucleotide binding
C4Q27_RS27660	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS27675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4Q27_RS27685	COG1215	transferase activity, transferring glycosyl groups
C4Q27_RS27700	COG3706	GGDEF domain
C4Q27_RS27705	COG2205	protein histidine kinase activity
C4Q27_RS27710	COG0745	RESPONSE REGULATOR receiver
C4Q27_RS27715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4Q27_RS27725	COG0746	molybdenum cofactor guanylyltransferase activity
C4Q27_RS27740	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS27765	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS27790	COG1132	(ABC) transporter
C4Q27_RS27795	COG3284	Transcriptional regulator
C4Q27_RS27825	COG2165	general secretion pathway protein
C4Q27_RS27830	COG2165	general secretion pathway protein
C4Q27_RS27835	COG4796	Type ii and iii secretion system protein
C4Q27_RS27860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4Q27_RS27865	COG2204	response regulator
C4Q27_RS27905	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS27920	COG2384	SAM-dependent methyltransferase
C4Q27_RS27930	COG0826	peptidase U32
C4Q27_RS27935	COG2204	response regulator
C4Q27_RS27980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4Q27_RS28000	COG0583	DNA-binding transcription factor activity
C4Q27_RS28005	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C4Q27_RS28025	COG3064	Membrane
C4Q27_RS28075	COG1309	transcriptional regulator
C4Q27_RS28085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS28095	COG3257	ureidoglycine aminohydrolase activity
C4Q27_RS28105	COG1522	sequence-specific DNA binding
C4Q27_RS28110	COG2423	ornithine cyclodeaminase activity
C4Q27_RS28115	COG0583	DNA-binding transcription factor activity
C4Q27_RS28120	COG0405	Gamma-glutamyltransferase
C4Q27_RS28130	COG2207	Transcriptional regulator
C4Q27_RS28135	COG0789	Transcriptional regulator
C4Q27_RS28145	COG1285	pathogenesis
C4Q27_RS28155	COG0348	domain, Protein
C4Q27_RS28160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4Q27_RS28170	COG4191	Histidine kinase
C4Q27_RS28170	COG0784	Response regulator, receiver
C4Q27_RS28175	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS28190	COG2814	Major facilitator Superfamily
C4Q27_RS28195	COG1566	PFAM secretion protein HlyD family protein
C4Q27_RS28200	COG1846	Transcriptional regulator
C4Q27_RS28205	COG4566	intracellular signal transduction
C4Q27_RS28210	COG4191	Histidine kinase
C4Q27_RS28215	COG0318	PFAM AMP-dependent synthetase and ligase
C4Q27_RS28220	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS28230	COG2056	Na+-H+ antiporter family
C4Q27_RS28240	COG0840	transmembrane signaling receptor activity
C4Q27_RS28250	COG4176	ABC-type proline glycine betaine transport system permease component
C4Q27_RS28280	COG1280	lysine exporter protein (LysE YggA)
C4Q27_RS28285	COG2814	Major facilitator Superfamily
C4Q27_RS28290	COG0583	DNA-binding transcription factor activity
C4Q27_RS28330	COG1028	Short-chain dehydrogenase reductase Sdr
C4Q27_RS28345	COG4774	siderophore transport
C4Q27_RS28350	COG3712	iron ion homeostasis
C4Q27_RS28355	COG1595	DNA-templated transcription, initiation
C4Q27_RS28405	COG2814	Major facilitator Superfamily
C4Q27_RS28410	COG0814	amino acid
C4Q27_RS28450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4Q27_RS28455	COG1126	abc transporter atp-binding protein
C4Q27_RS28460	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4Q27_RS28470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4Q27_RS28475	COG2271	Major facilitator Superfamily
C4Q27_RS28480	COG2721	sulfolactate sulfo-lyase activity
C4Q27_RS28485	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS28490	COG2186	Transcriptional regulator
C4Q27_RS28505	COG0583	DNA-binding transcription factor activity
C4Q27_RS28515	COG2391	methyltransferase activity
C4Q27_RS28530	COG4335	DNA alkylation repair
C4Q27_RS28575	COG1944	ATP diphosphatase activity
C4Q27_RS28615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4Q27_RS28625	COG4991	sh3 domain protein
C4Q27_RS28635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4Q27_RS28645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4Q27_RS28650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4Q27_RS28675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4Q27_RS28685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4Q27_RS28695	COG2267	carboxylic ester hydrolase activity
C4Q27_RS28700	COG1012	belongs to the aldehyde dehydrogenase family
C4Q27_RS28710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4Q27_RS28715	COG2186	Transcriptional regulator
C4Q27_RS28720	COG2816	NAD+ diphosphatase activity
C4Q27_RS28725	COG4191	Histidine kinase
C4Q27_RS28725	COG0784	Response regulator, receiver
C4Q27_RS28730	COG1280	lysine exporter protein (LysE YggA)
C4Q27_RS28745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4Q27_RS28760	COG2814	Major facilitator Superfamily
C4Q27_RS28770	COG2030	dehydratase
C4Q27_RS28780	COG2855	membrane
C4Q27_RS28785	COG1611	Belongs to the LOG family
C4Q27_RS28790	COG5001	Diguanylate cyclase
C4Q27_RS28790	COG3300	MHYT domain
C4Q27_RS28795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4Q27_RS28805	COG0477	Major facilitator Superfamily
C4Q27_RS28815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C4Q27_RS28830	COG0656	L-ascorbic acid biosynthetic process
C4Q27_RS28835	COG5001	Diguanylate cyclase
C4Q27_RS28845	COG3485	protocatechuate 3,4-dioxygenase
C4Q27_RS28850	COG4829	muconolactone delta-isomerase
C4Q27_RS28855	COG4948	Mandelate Racemase Muconate Lactonizing
C4Q27_RS28885	COG3192	ethanolamine utilization protein
C4Q27_RS28905	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4Q27_RS28920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4Q27_RS28930	COG0045	succinate-CoA ligase (ADP-forming) activity
C4Q27_RS28935	COG1960	acyl-CoA dehydrogenase activity
C4Q27_RS28940	COG1024	Enoyl-CoA hydratase
C4Q27_RS28945	COG0833	amino acid
C4Q27_RS28970	COG1024	Enoyl-CoA hydratase
C4Q27_RS28975	COG2885	chlorophyll binding
C4Q27_RS29095	COG0577	efflux transmembrane transporter activity
C4Q27_RS29100	COG4181	ATPase activity
C4Q27_RS29140	COG0768	penicillin binding
C4Q27_RS29155	COG2186	Transcriptional regulator
C4Q27_RS29160	COG0277	FAD linked oxidase domain protein
C4Q27_RS29165	COG0277	FAD linked oxidase domain protein
C4Q27_RS29170	COG0247	lactate metabolic process
C4Q27_RS29175	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4Q27_RS29190	COG2807	transmembrane transport
C4Q27_RS29195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity