locus-tag	class	description
THL1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THL1_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THL1_RS00025	COG4372	Transposase
THL1_RS00070	COG2818	Glycosylase
THL1_RS00090	COG0569	domain protein
THL1_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THL1_RS00105	COG0242	peptide deformylase activity
THL1_RS00110	COG1652	LysM domain
THL1_RS00115	COG0758	DNA mediated transformation
THL1_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
THL1_RS00135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THL1_RS00150	COG3119	arylsulfatase activity
THL1_RS00155	COG0583	DNA-binding transcription factor activity
THL1_RS00165	COG0159	tryptophan synthase activity
THL1_RS00180	COG3360	Dodecin
THL1_RS00190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THL1_RS00220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THL1_RS00250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THL1_RS00250	COG1565	acr, cog1565
THL1_RS00255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THL1_RS00260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
THL1_RS00290	COG0109	protoheme IX farnesyltransferase activity
THL1_RS00300	COG1464	Belongs to the NlpA lipoprotein family
THL1_RS00305	COG2011	ABC-type metal ion transport system permease component
THL1_RS00310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THL1_RS00325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THL1_RS00335	COG0735	belongs to the Fur family
THL1_RS00340	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
THL1_RS00370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THL1_RS00400	COG0415	Belongs to the DNA photolyase family
THL1_RS00405	COG2095	MarC family integral membrane protein
THL1_RS00410	COG3023	N-Acetylmuramoyl-L-alanine amidase
THL1_RS00415	COG5002	protein histidine kinase activity
THL1_RS00420	COG2204	response regulator
THL1_RS00430	COG0700	Nucleoside recognition
THL1_RS00445	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THL1_RS00450	COG1074	ATP-dependent DNA helicase activity
THL1_RS00455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THL1_RS00460	COG0861	Integral membrane protein TerC family
THL1_RS00465	COG2851	Citrate transporter
THL1_RS00505	COG0427	acetyl-CoA hydrolase
THL1_RS00525	COG3415	Transposase
THL1_RS00525	COG2801	Transposase and inactivated derivatives
THL1_RS00530	COG2197	response regulator
THL1_RS00545	COG0583	DNA-binding transcription factor activity
THL1_RS00550	COG1960	acyl-CoA dehydrogenase activity
THL1_RS00555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THL1_RS00585	COG0252	asparaginase activity
THL1_RS00600	COG3328	transposase activity
THL1_RS00640	COG4221	oxidoreductase activity
THL1_RS00650	COG1309	transcriptional regulator
THL1_RS00695	COG4208	sulfate ABC transporter
THL1_RS00705	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
THL1_RS00710	COG5583	Uncharacterized small protein (DUF2292)
THL1_RS00735	COG1566	PFAM secretion protein HlyD family protein
THL1_RS00745	COG3706	GGDEF domain
THL1_RS00775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THL1_RS00795	COG3052	prosthetic group binding
THL1_RS00800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
THL1_RS00815	COG2814	Major facilitator Superfamily
THL1_RS00820	COG1126	abc transporter atp-binding protein
THL1_RS00825	COG0765	amino acid transport
THL1_RS00830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS00845	COG2188	Transcriptional regulator
THL1_RS00850	COG1053	succinate dehydrogenase
THL1_RS00865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THL1_RS00885	COG2175	clavaminate synthase activity
THL1_RS00890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THL1_RS00895	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
THL1_RS00900	COG4521	taurine ABC transporter
THL1_RS00910	COG0450	alkyl hydroperoxide reductase
THL1_RS00915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THL1_RS00920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THL1_RS00925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THL1_RS00940	COG2957	Belongs to the agmatine deiminase family
THL1_RS00960	COG0174	glutamine synthetase
THL1_RS00965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THL1_RS00970	COG0174	glutamine synthetase
THL1_RS00990	COG3842	ATPase activity
THL1_RS00995	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS01000	COG1177	transmembrane transport
THL1_RS01010	COG0730	response to heat
THL1_RS01015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THL1_RS01020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THL1_RS01025	COG3719	Belongs to the RNase T2 family
THL1_RS01035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THL1_RS01045	COG2233	PERMEase
THL1_RS01055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THL1_RS01065	COG2233	PERMEase
THL1_RS01095	COG4215	(ABC) transporter
THL1_RS01105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS01110	COG1126	abc transporter atp-binding protein
THL1_RS01115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THL1_RS01125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THL1_RS01145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THL1_RS01155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
THL1_RS01175	COG0429	hydrolase of the alpha beta-hydrolase fold
THL1_RS01180	COG0742	ribosomal rna small subunit methyltransferase
THL1_RS01185	COG0612	Peptidase, M16
THL1_RS01190	COG0612	Peptidase, M16
THL1_RS01195	COG0552	protein localization to endoplasmic reticulum
THL1_RS01200	COG2884	Cell division ATP-binding protein ftsE
THL1_RS01205	COG2177	Part of the ABC transporter FtsEX involved in
THL1_RS01220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THL1_RS01225	COG2363	Small membrane protein
THL1_RS01235	COG2022	thiamine diphosphate biosynthetic process
THL1_RS01240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THL1_RS01260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THL1_RS01265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THL1_RS01275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THL1_RS01275	COG2813	Specifically methylates the guanine in position
THL1_RS01280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THL1_RS01285	COG1160	GTP binding
THL1_RS01290	COG1872	DUF167
THL1_RS01330	COG0626	cystathionine gamma-synthase activity
THL1_RS01370	COG1683	Conserved Protein
THL1_RS01375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS01380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THL1_RS01385	COG0277	FAD linked oxidase domain protein
THL1_RS01390	COG0179	Fumarylacetoacetate (FAA) hydrolase
THL1_RS01395	COG3204	pilus organization
THL1_RS01410	COG0531	amino acid
THL1_RS01420	COG1177	transmembrane transport
THL1_RS01425	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS01430	COG3842	ATPase activity
THL1_RS01455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THL1_RS01475	COG0494	nUDIX hydrolase
THL1_RS01480	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
THL1_RS01490	COG0540	Belongs to the ATCase OTCase family
THL1_RS01515	COG0189	ligase activity
THL1_RS01545	COG0643	Histidine kinase
THL1_RS01545	COG0784	Response regulator, receiver
THL1_RS01545	COG2198	Histidine kinase
THL1_RS01550	COG2201	protein-glutamate methylesterase activity
THL1_RS01560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THL1_RS01575	COG3038	cytochrome b561
THL1_RS01580	COG2353	YceI-like domain
THL1_RS01585	COG2353	YceI-like domain
THL1_RS01590	COG0513	Belongs to the DEAD box helicase family
THL1_RS01600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THL1_RS01620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THL1_RS01630	COG0640	Transcriptional regulator
THL1_RS01640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THL1_RS01645	COG0126	phosphoglycerate kinase activity
THL1_RS01670	COG1451	nucleotide metabolic process
THL1_RS01690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THL1_RS01700	COG1289	transmembrane transporter activity
THL1_RS01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS01710	COG0513	Belongs to the DEAD box helicase family
THL1_RS01730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THL1_RS01755	COG4175	Glycine betaine
THL1_RS01765	COG1760	l-serine dehydratase
THL1_RS01785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THL1_RS01790	COG2181	nitrate reductase activity
THL1_RS01790	COG0247	lactate metabolic process
THL1_RS01795	COG1902	pentaerythritol trinitrate reductase activity
THL1_RS01795	COG0446	pyridine nucleotide-disulphide oxidoreductase
THL1_RS01820	COG3383	formate dehydrogenase (NAD+) activity
THL1_RS01840	COG3246	L-lysine catabolic process to acetate
THL1_RS01855	COG2197	response regulator
THL1_RS01860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS01860	COG2205	protein histidine kinase activity
THL1_RS01865	COG2199	diguanylate cyclase activity
THL1_RS01865	COG2203	Gaf domain
THL1_RS01865	COG2200	EAL domain
THL1_RS01870	COG2197	response regulator
THL1_RS01880	COG3121	Chaperone
THL1_RS01895	COG1017	nitric oxide dioxygenase activity
THL1_RS01895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THL1_RS01900	COG0625	glutathione transferase activity
THL1_RS01920	COG1760	l-serine dehydratase
THL1_RS01945	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS01950	COG1177	transmembrane transport
THL1_RS01955	COG3842	ATPase activity
THL1_RS02005	COG1063	alcohol dehydrogenase
THL1_RS02020	COG2197	response regulator
THL1_RS02030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THL1_RS02035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THL1_RS02070	COG0204	Acyl-transferase
THL1_RS02085	COG0745	RESPONSE REGULATOR receiver
THL1_RS02090	COG2205	protein histidine kinase activity
THL1_RS02100	COG4452	Inner membrane protein CreD
THL1_RS02105	COG0625	glutathione transferase activity
THL1_RS02120	COG0745	RESPONSE REGULATOR receiver
THL1_RS02145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THL1_RS02150	COG3585	molybdate ion transport
THL1_RS02150	COG2005	Transcriptional regulator
THL1_RS02155	COG1040	competence protein
THL1_RS02170	COG0156	8-amino-7-oxononanoate synthase activity
THL1_RS02175	COG2226	methyltransferase
THL1_RS02175	COG1073	alpha beta
THL1_RS02195	COG1960	acyl-CoA dehydrogenase activity
THL1_RS02205	COG1960	acyl-CoA dehydrogenase activity
THL1_RS02210	COG1960	acyl-CoA dehydrogenase activity
THL1_RS02215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THL1_RS02255	COG0583	DNA-binding transcription factor activity
THL1_RS02265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS02275	COG0174	glutamine synthetase
THL1_RS02285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS02290	COG0010	Belongs to the arginase family
THL1_RS02300	COG2610	gluconate transmembrane transporter activity
THL1_RS02315	COG0583	DNA-binding transcription factor activity
THL1_RS02320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THL1_RS02325	COG0402	S-adenosylhomocysteine deaminase activity
THL1_RS02340	COG1177	transmembrane transport
THL1_RS02345	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS02350	COG3842	ATPase activity
THL1_RS02355	COG2188	Transcriptional regulator
THL1_RS02390	COG2259	Doxx family
THL1_RS02405	COG1113	amino acid transport
THL1_RS02430	COG0765	amino acid transport
THL1_RS02445	COG1917	Cupin 2, conserved barrel domain protein
THL1_RS02470	COG3971	2-oxopent-4-enoate hydratase activity
THL1_RS02535	COG0358	DNA primase activity
THL1_RS02545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THL1_RS02550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THL1_RS02575	COG2719	SpoVR family
THL1_RS02580	COG2718	Belongs to the UPF0229 family
THL1_RS02585	COG2766	serine protein kinase
THL1_RS02590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THL1_RS02600	COG2967	ApaG domain
THL1_RS02605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THL1_RS02620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THL1_RS02630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THL1_RS02635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
THL1_RS02650	COG2197	response regulator
THL1_RS02655	COG3842	ATPase activity
THL1_RS02665	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS02690	COG0582	viral genome integration into host DNA
THL1_RS02695	COG3328	transposase activity
THL1_RS02770	COG3344	reverse transcriptase
THL1_RS02805	COG1802	Transcriptional regulator
THL1_RS02815	COG0579	oxidoreductase
THL1_RS02830	COG1113	amino acid transport
THL1_RS02845	COG3706	GGDEF domain
THL1_RS02850	COG3039	Transposase
THL1_RS02875	COG2201	protein-glutamate methylesterase activity
THL1_RS02885	COG2204	response regulator
THL1_RS02895	COG3852	Histidine kinase
THL1_RS02905	COG4584	PFAM Integrase catalytic
THL1_RS02925	COG4584	PFAM Integrase catalytic
THL1_RS02950	COG0835	chemotaxis
THL1_RS02960	COG0835	chemotaxis
THL1_RS02975	COG2201	protein-glutamate methylesterase activity
THL1_RS02985	COG4974	Belongs to the 'phage' integrase family
THL1_RS03010	COG1596	polysaccharide export
THL1_RS03015	COG3206	protein involved in exopolysaccharide biosynthesis
THL1_RS03015	COG0489	protein tyrosine kinase activity
THL1_RS03030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THL1_RS03065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THL1_RS03085	COG3436	PFAM IS66 Orf2 family protein
THL1_RS03235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THL1_RS03245	COG1289	transmembrane transporter activity
THL1_RS03265	COG3665	Urea carboxylase-associated protein
THL1_RS03275	COG1126	abc transporter atp-binding protein
THL1_RS03280	COG0765	amino acid transport
THL1_RS03285	COG0765	amino acid transport
THL1_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS03305	COG0512	Glutamine amidotransferase of anthranilate synthase
THL1_RS03325	COG1765	OsmC-like protein
THL1_RS03335	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THL1_RS03340	COG0537	adenosine 5'-monophosphoramidase activity
THL1_RS03365	COG1981	membrane
THL1_RS03375	COG0316	Belongs to the HesB IscA family
THL1_RS03380	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
THL1_RS03385	COG0739	heme binding
THL1_RS03390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THL1_RS03425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THL1_RS03470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THL1_RS03480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THL1_RS03490	COG0085	RNA polymerase activity
THL1_RS03495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THL1_RS03500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THL1_RS03505	COG0049	tRNA binding
THL1_RS03510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THL1_RS03520	COG0051	transcription antitermination factor activity, RNA binding
THL1_RS03525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THL1_RS03530	COG0088	Forms part of the polypeptide exit tunnel
THL1_RS03540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THL1_RS03550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THL1_RS03555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THL1_RS03570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THL1_RS03575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THL1_RS03580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THL1_RS03585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THL1_RS03590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THL1_RS03595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THL1_RS03610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THL1_RS03620	COG0200	Binds to the 23S rRNA
THL1_RS03630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THL1_RS03635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THL1_RS03645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THL1_RS03655	COG0203	ribosomal protein L17
THL1_RS03660	COG0753	catalase activity
THL1_RS03670	COG2814	Major facilitator Superfamily
THL1_RS03690	COG1595	DNA-templated transcription, initiation
THL1_RS03710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THL1_RS03745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THL1_RS03785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THL1_RS03790	COG3047	cAMP biosynthetic process
THL1_RS03805	COG1136	(ABC) transporter
THL1_RS03805	COG0577	efflux transmembrane transporter activity
THL1_RS03820	COG3118	belongs to the thioredoxin family
THL1_RS03825	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS03830	COG2264	protein methyltransferase activity
THL1_RS03845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THL1_RS03845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THL1_RS03860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THL1_RS03870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THL1_RS03875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THL1_RS03880	COG3577	Aspartyl protease
THL1_RS03885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THL1_RS03900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THL1_RS03905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
THL1_RS03925	COG0142	geranyltranstransferase activity
THL1_RS03930	COG1722	exodeoxyribonuclease VII activity
THL1_RS03935	COG0730	response to heat
THL1_RS03945	COG3415	Transposase
THL1_RS03945	COG2801	Transposase and inactivated derivatives
THL1_RS03950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THL1_RS03960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THL1_RS03975	COG1596	polysaccharide export
THL1_RS03985	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THL1_RS04005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THL1_RS04015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THL1_RS04020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THL1_RS04030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THL1_RS04040	COG3206	protein involved in exopolysaccharide biosynthesis
THL1_RS04040	COG0489	protein tyrosine kinase activity
THL1_RS04050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THL1_RS04060	COG3228	Belongs to the MtfA family
THL1_RS04065	COG0586	Pfam SNARE associated Golgi protein
THL1_RS04075	COG1484	DNA-dependent DNA replication
THL1_RS04080	COG0456	acetyltransferase
THL1_RS04090	COG4303	Ethanolamine ammonia lyase large subunit
THL1_RS04110	COG3284	Transcriptional regulator
THL1_RS04125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THL1_RS04135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THL1_RS04150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THL1_RS04155	COG2226	methyltransferase
THL1_RS04160	COG0702	epimerase
THL1_RS04180	COG1346	cytolysis
THL1_RS04190	COG0586	Pfam SNARE associated Golgi protein
THL1_RS04230	COG0768	penicillin binding
THL1_RS04235	COG0772	Belongs to the SEDS family
THL1_RS04240	COG2951	lytic endotransglycosylase activity
THL1_RS04250	COG1686	Belongs to the peptidase S11 family
THL1_RS04260	COG0321	lipoyl(octanoyl) transferase activity
THL1_RS04265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THL1_RS04270	COG2951	lytic endotransglycosylase activity
THL1_RS04290	COG0495	leucyl-tRNA aminoacylation
THL1_RS04300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
THL1_RS04305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THL1_RS04310	COG4535	Mg2 and Co2 transporter CorC
THL1_RS04315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THL1_RS04320	COG1702	phosphate starvation-inducible protein PhoH
THL1_RS04340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THL1_RS04350	COG0351	phosphomethylpyrimidine kinase
THL1_RS04365	COG1960	acyl-CoA dehydrogenase activity
THL1_RS04370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THL1_RS04390	COG1522	sequence-specific DNA binding
THL1_RS04405	COG1643	Atp-dependent helicase
THL1_RS04410	COG0583	DNA-binding transcription factor activity
THL1_RS04420	COG3618	amidohydrolase
THL1_RS04430	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THL1_RS04440	COG0523	cobalamin synthesis protein
THL1_RS04445	COG2233	PERMEase
THL1_RS04505	COG1522	sequence-specific DNA binding
THL1_RS04510	COG0697	spore germination
THL1_RS04515	COG0513	Belongs to the DEAD box helicase family
THL1_RS04525	COG3842	ATPase activity
THL1_RS04540	COG1177	transmembrane transport
THL1_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS04565	COG0123	including yeast histone deacetylase and acetoin utilization protein
THL1_RS04580	COG1946	Acyl-CoA thioesterase
THL1_RS04590	COG2852	Protein conserved in bacteria
THL1_RS04595	COG2321	neutral zinc metallopeptidase
THL1_RS04615	COG2252	PERMEase
THL1_RS04620	COG0693	protein deglycase activity
THL1_RS04645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
THL1_RS04655	COG1271	oxidase subunit
THL1_RS04660	COG1294	oxidase, subunit
THL1_RS04685	COG3278	Belongs to the heme-copper respiratory oxidase family
THL1_RS04690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THL1_RS04700	COG1253	flavin adenine dinucleotide binding
THL1_RS04735	COG1966	Carbon starvation protein
THL1_RS04740	COG2879	small protein
THL1_RS04755	COG0488	(ABC) transporter
THL1_RS04765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THL1_RS04775	COG1690	Belongs to the RtcB family
THL1_RS04790	COG1067	ATP-dependent peptidase activity
THL1_RS04805	COG0545	Peptidyl-prolyl cis-trans isomerase
THL1_RS04815	COG0142	geranyltranstransferase activity
THL1_RS04820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THL1_RS04835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THL1_RS04840	COG3045	CreA protein
THL1_RS04855	COG0196	riboflavin kinase activity
THL1_RS04870	COG1047	Peptidyl-prolyl cis-trans
THL1_RS04875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THL1_RS04915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS04965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THL1_RS04965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THL1_RS04970	COG2801	Transposase and inactivated derivatives
THL1_RS04970	COG3415	Transposase
THL1_RS05025	COG1252	NADH dehydrogenase
THL1_RS05065	COG0237	dephospho-CoA kinase activity
THL1_RS05070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THL1_RS05115	COG3415	Transposase
THL1_RS05115	COG2801	Transposase and inactivated derivatives
THL1_RS05125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THL1_RS05135	COG0084	hydrolase, TatD family'
THL1_RS05160	COG1309	transcriptional regulator
THL1_RS05170	COG0019	diaminopimelate decarboxylase activity
THL1_RS05180	COG4774	siderophore transport
THL1_RS05185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THL1_RS05200	COG1984	allophanate hydrolase subunit 2
THL1_RS05205	COG4608	Belongs to the ABC transporter superfamily
THL1_RS05210	COG0444	Belongs to the ABC transporter superfamily
THL1_RS05215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THL1_RS05220	COG0601	transmembrane transport
THL1_RS05225	COG0747	negative chemotaxis
THL1_RS05235	COG0006	proline dipeptidase activity
THL1_RS05240	COG0747	negative chemotaxis
THL1_RS05245	COG0747	negative chemotaxis
THL1_RS05260	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
THL1_RS05270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
THL1_RS05275	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THL1_RS05280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THL1_RS05290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THL1_RS05295	COG1077	Cell shape determining protein MreB Mrl
THL1_RS05300	COG1792	Involved in formation and maintenance of cell shape
THL1_RS05310	COG0424	maF-like protein
THL1_RS05325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THL1_RS05330	COG0312	modulator of DNA gyrase
THL1_RS05335	COG3028	Belongs to the UPF0307 family
THL1_RS05340	COG0312	modulator of DNA gyrase
THL1_RS05350	COG1660	Displays ATPase and GTPase activities
THL1_RS05365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THL1_RS05370	COG1137	ATPase activity
THL1_RS05385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THL1_RS05395	COG1127	ABC transporter
THL1_RS05400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THL1_RS05405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THL1_RS05430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THL1_RS05435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THL1_RS05440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THL1_RS05445	COG4372	Transposase
THL1_RS05450	COG3436	PFAM IS66 Orf2 family protein
THL1_RS05465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THL1_RS05500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THL1_RS05515	COG1960	acyl-CoA dehydrogenase activity
THL1_RS05525	COG0667	Aldo Keto reductase
THL1_RS05530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THL1_RS05540	COG0723	plastoquinol--plastocyanin reductase activity
THL1_RS05545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THL1_RS05550	COG2857	Cytochrome c1
THL1_RS05555	COG0625	glutathione transferase activity
THL1_RS05560	COG2969	positive regulation of protein catabolic process
THL1_RS05565	COG2823	Periplasmic or secreted lipoprotein
THL1_RS05580	COG3107	peptidoglycan biosynthetic process
THL1_RS05615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THL1_RS05620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THL1_RS05630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THL1_RS05635	COG0772	Belongs to the SEDS family
THL1_RS05640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THL1_RS05645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THL1_RS05650	COG1181	Belongs to the D-alanine--D-alanine ligase family
THL1_RS05670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THL1_RS05690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THL1_RS05700	COG0494	nUDIX hydrolase
THL1_RS05710	COG2096	Adenosyltransferase
THL1_RS05725	COG0745	RESPONSE REGULATOR receiver
THL1_RS05730	COG1666	GTP binding
THL1_RS05735	COG0668	transmembrane transport
THL1_RS05745	COG2211	Major facilitator Superfamily
THL1_RS05750	COG3695	enzyme binding
THL1_RS05795	COG3081	Nucleoid-associated protein
THL1_RS05805	COG0420	3'-5' exonuclease activity
THL1_RS05810	COG0419	ATPase involved in DNA repair
THL1_RS05815	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
THL1_RS05825	COG0490	domain, Protein
THL1_RS05825	COG0471	metal ion transport
THL1_RS05855	COG0795	lipopolysaccharide-transporting ATPase activity
THL1_RS05860	COG0795	lipopolysaccharide-transporting ATPase activity
THL1_RS05870	COG1278	Cold shock
THL1_RS05880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THL1_RS05890	COG1862	Preprotein translocase
THL1_RS05905	COG3134	Outer membrane lipoprotein
THL1_RS05920	COG1045	serine acetyltransferase
THL1_RS05940	COG0316	Belongs to the HesB IscA family
THL1_RS05985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THL1_RS06005	COG1160	GTP binding
THL1_RS06010	COG0436	Aminotransferase
THL1_RS06020	COG1733	regulation of RNA biosynthetic process
THL1_RS06030	COG0668	transmembrane transport
THL1_RS06035	COG0739	heme binding
THL1_RS06040	COG1570	exodeoxyribonuclease VII activity
THL1_RS06060	COG0582	viral genome integration into host DNA
THL1_RS06110	COG2205	protein histidine kinase activity
THL1_RS06110	COG0784	Response regulator, receiver
THL1_RS06115	COG2204	response regulator
THL1_RS06130	COG5001	Diguanylate cyclase
THL1_RS06160	COG4964	Belongs to the GSP D family
THL1_RS06195	COG0590	tRNA wobble adenosine to inosine editing
THL1_RS06215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THL1_RS06225	COG0697	spore germination
THL1_RS06250	COG0300	oxidoreductase activity
THL1_RS06320	COG2801	Transposase and inactivated derivatives
THL1_RS06320	COG3415	Transposase
THL1_RS06325	COG3022	response to hydroperoxide
THL1_RS06330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THL1_RS06335	COG0315	cyclic pyranopterin monophosphate synthase activity
THL1_RS06340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THL1_RS06355	COG1126	abc transporter atp-binding protein
THL1_RS06360	COG0765	amino acid transport
THL1_RS06365	COG4597	amino acid ABC transporter
THL1_RS06370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS06375	COG0400	carboxylic ester hydrolase activity
THL1_RS06400	COG0714	Associated with various cellular activities
THL1_RS06425	COG2925	Exonuclease
THL1_RS06435	COG0788	formyltetrahydrofolate deformylase activity
THL1_RS06440	COG0517	IMP dehydrogenase activity
THL1_RS06440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THL1_RS06440	COG0617	tRNA 3'-terminal CCA addition
THL1_RS06450	COG0433	COG0433 Predicted ATPase
THL1_RS06455	COG0306	phosphate transporter
THL1_RS06465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THL1_RS06470	COG0348	domain, Protein
THL1_RS06475	COG0494	nUDIX hydrolase
THL1_RS06495	COG0657	acetylesterase activity
THL1_RS06500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THL1_RS06515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THL1_RS06530	COG1053	succinate dehydrogenase
THL1_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS06545	COG1686	Belongs to the peptidase S11 family
THL1_RS06550	COG2271	Major facilitator Superfamily
THL1_RS06555	COG1082	Xylose isomerase domain protein TIM barrel
THL1_RS06565	COG0583	DNA-binding transcription factor activity
THL1_RS06575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THL1_RS06585	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS06600	COG2205	protein histidine kinase activity
THL1_RS06610	COG2207	Transcriptional regulator
THL1_RS06615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THL1_RS06630	COG2076	Multidrug Resistance protein
THL1_RS06660	COG0545	Peptidyl-prolyl cis-trans isomerase
THL1_RS06665	COG3339	Conserved Protein
THL1_RS06690	COG2200	EAL domain
THL1_RS06700	COG3321	synthase
THL1_RS06700	COG4221	oxidoreductase activity
THL1_RS06700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
THL1_RS06700	COG0604	alcohol dehydrogenase
THL1_RS06725	COG0560	Phosphoserine phosphatase
THL1_RS06730	COG3842	ATPase activity
THL1_RS06740	COG0395	ABC-type sugar transport system, permease component
THL1_RS06755	COG2188	Transcriptional regulator
THL1_RS06760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THL1_RS06765	COG1362	aminopeptidase activity
THL1_RS06775	COG0564	pseudouridine synthase activity
THL1_RS06780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THL1_RS06785	COG2894	cell division
THL1_RS06790	COG0850	regulation of cytokinetic process
THL1_RS06795	COG1560	Kdo2-lipid A biosynthetic process
THL1_RS06805	COG2853	Lipoprotein
THL1_RS06830	COG3162	membrane
THL1_RS06835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THL1_RS06870	COG1742	UPF0060 membrane protein
THL1_RS06875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THL1_RS06885	COG3089	Belongs to the UPF0270 family
THL1_RS06935	COG0183	Belongs to the thiolase family
THL1_RS06945	COG0697	spore germination
THL1_RS06950	COG2249	NAD(P)H dehydrogenase (quinone) activity
THL1_RS06955	COG0114	fumarate hydratase activity
THL1_RS06970	COG0271	Belongs to the BolA IbaG family
THL1_RS06975	COG1054	Belongs to the UPF0176 family
THL1_RS07000	COG0625	glutathione transferase activity
THL1_RS07005	COG1113	amino acid transport
THL1_RS07015	COG0840	transmembrane signaling receptor activity
THL1_RS07030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THL1_RS07040	COG0346	lactoylglutathione lyase activity
THL1_RS07055	COG1024	Enoyl-CoA hydratase
THL1_RS07060	COG2070	2-Nitropropane dioxygenase
THL1_RS07065	COG1024	Enoyl-CoA hydratase
THL1_RS07070	COG1960	acyl-CoA dehydrogenase activity
THL1_RS07075	COG1960	acyl-CoA dehydrogenase activity
THL1_RS07080	COG0183	Belongs to the thiolase family
THL1_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS07110	COG1960	acyl-CoA dehydrogenase activity
THL1_RS07115	COG1960	acyl-CoA dehydrogenase activity
THL1_RS07130	COG0183	Belongs to the thiolase family
THL1_RS07150	COG0596	Alpha beta hydrolase
THL1_RS07175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THL1_RS07185	COG0840	transmembrane signaling receptor activity
THL1_RS07195	COG0643	Histidine kinase
THL1_RS07195	COG2198	Histidine kinase
THL1_RS07200	COG0745	RESPONSE REGULATOR receiver
THL1_RS07205	COG0840	transmembrane signaling receptor activity
THL1_RS07220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THL1_RS07220	COG0475	glutathione-regulated potassium exporter activity
THL1_RS07225	COG1335	isochorismatase
THL1_RS07240	COG0583	DNA-binding transcription factor activity
THL1_RS07245	COG3842	ATPase activity
THL1_RS07255	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS07265	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS07270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THL1_RS07285	COG2186	Transcriptional regulator
THL1_RS07290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
THL1_RS07300	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS07305	COG2267	carboxylic ester hydrolase activity
THL1_RS07325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THL1_RS07325	COG0446	pyridine nucleotide-disulphide oxidoreductase
THL1_RS07340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THL1_RS07375	COG2814	Major facilitator Superfamily
THL1_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS07405	COG0765	amino acid transport
THL1_RS07410	COG0165	Argininosuccinate lyase
THL1_RS07445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THL1_RS07450	COG2218	PFAM glutamate synthase alpha subunit domain protein
THL1_RS07455	COG0069	glutamate synthase activity
THL1_RS07460	COG0004	ammonium transporteR
THL1_RS07465	COG0347	Belongs to the P(II) protein family
THL1_RS07480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THL1_RS07485	COG0492	ferredoxin-NADP+ reductase activity
THL1_RS07490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THL1_RS07500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THL1_RS07520	COG2197	response regulator
THL1_RS07525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THL1_RS07530	COG3433	isochorismatase activity
THL1_RS07530	COG1535	isochorismatase
THL1_RS07535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THL1_RS07545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THL1_RS07555	COG0741	lytic transglycosylase activity
THL1_RS07560	COG0393	Putative heavy-metal-binding
THL1_RS07565	COG1764	response to oxidative stress
THL1_RS07590	COG1653	transport
THL1_RS07595	COG1175	transmembrane transport
THL1_RS07600	COG0395	ABC-type sugar transport system, permease component
THL1_RS07605	COG3842	ATPase activity
THL1_RS07610	COG4580	involved in the transport of maltose and maltodextrins
THL1_RS07615	COG0676	glucose-6-phosphate 1-epimerase activity
THL1_RS07620	COG1737	Transcriptional regulator
THL1_RS07635	COG0800	Aldolase
THL1_RS07645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THL1_RS07660	COG4948	Mandelate Racemase Muconate Lactonizing
THL1_RS07665	COG4829	muconolactone delta-isomerase
THL1_RS07670	COG3485	protocatechuate 3,4-dioxygenase
THL1_RS07675	COG0657	acetylesterase activity
THL1_RS07695	COG0411	ABC transporter
THL1_RS07715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THL1_RS07715	COG0543	2 iron, 2 sulfur cluster binding
THL1_RS07720	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
THL1_RS07725	COG4638	Rieske (2fe-2S)
THL1_RS07740	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS07750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS07755	COG2814	Major facilitator Superfamily
THL1_RS07780	COG1802	Transcriptional regulator
THL1_RS07790	COG0579	oxidoreductase
THL1_RS07810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS07815	COG1126	abc transporter atp-binding protein
THL1_RS07820	COG0765	amino acid transport
THL1_RS07825	COG0765	amino acid transport
THL1_RS07830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THL1_RS07835	COG3938	Belongs to the proline racemase family
THL1_RS07840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS07845	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS07850	COG3938	Belongs to the proline racemase family
THL1_RS07855	COG1802	Transcriptional regulator
THL1_RS07870	COG0626	cystathionine gamma-synthase activity
THL1_RS07875	COG0833	amino acid
THL1_RS07880	COG0583	DNA-binding transcription factor activity
THL1_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS07905	COG0251	oxidation-reduction process
THL1_RS07915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THL1_RS07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS07925	COG0765	amino acid transport
THL1_RS07930	COG1126	abc transporter atp-binding protein
THL1_RS07940	COG1737	Transcriptional regulator
THL1_RS07950	COG4566	intracellular signal transduction
THL1_RS07970	COG0500	methyltransferase
THL1_RS07980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THL1_RS08030	COG4783	chaperone-mediated protein folding
THL1_RS08055	COG0174	glutamine synthetase
THL1_RS08060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS08070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THL1_RS08080	COG4659	FMN binding
THL1_RS08095	COG4657	Part of a membrane complex involved in electron transport
THL1_RS08105	COG0489	protein tyrosine kinase activity
THL1_RS08115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THL1_RS08120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THL1_RS08130	COG0653	protein targeting
THL1_RS08145	COG3012	SEC-C Motif Domain Protein
THL1_RS08175	COG1199	ATP-dependent helicase activity
THL1_RS08190	COG2885	chlorophyll binding
THL1_RS08195	COG0259	pyridoxamine-phosphate oxidase activity
THL1_RS08210	COG2111	Na H antiporter
THL1_RS08210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THL1_RS08215	COG1006	Multisubunit Na H antiporter MnhC subunit
THL1_RS08220	COG0651	ATP synthesis coupled electron transport
THL1_RS08225	COG1863	multisubunit Na H antiporter MnhE subunit
THL1_RS08230	COG2212	antiporter activity
THL1_RS08245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THL1_RS08265	COG0583	DNA-binding transcription factor activity
THL1_RS08270	COG0583	DNA-binding transcription factor activity
THL1_RS08290	COG1566	PFAM secretion protein HlyD family protein
THL1_RS08300	COG2197	response regulator
THL1_RS08310	COG0531	amino acid
THL1_RS08315	COG1609	Transcriptional regulator
THL1_RS08325	COG1105	Belongs to the carbohydrate kinase PfkB family
THL1_RS08330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
THL1_RS08330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THL1_RS08330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THL1_RS08345	COG2154	pterin-4-alpha-carbinolamine dehydratase
THL1_RS08360	COG2076	Multidrug Resistance protein
THL1_RS08365	COG2076	Multidrug Resistance protein
THL1_RS08370	COG0583	DNA-binding transcription factor activity
THL1_RS08400	COG0656	L-ascorbic acid biosynthetic process
THL1_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THL1_RS08445	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THL1_RS08450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THL1_RS08470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THL1_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS08500	COG3842	ATPase activity
THL1_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS08510	COG0069	glutamate synthase activity
THL1_RS08555	COG3639	organic phosphonate transmembrane transporter activity
THL1_RS08560	COG3639	organic phosphonate transmembrane transporter activity
THL1_RS08570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
THL1_RS08575	COG2084	Dehydrogenase
THL1_RS08580	COG3622	Belongs to the hyi family
THL1_RS08590	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THL1_RS08600	COG2271	Major facilitator Superfamily
THL1_RS08605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THL1_RS08630	COG1132	(ABC) transporter
THL1_RS08640	COG2267	carboxylic ester hydrolase activity
THL1_RS08655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
THL1_RS08665	COG0513	Belongs to the DEAD box helicase family
THL1_RS08695	COG2996	Protein conserved in bacteria
THL1_RS08715	COG0697	spore germination
THL1_RS08720	COG0583	DNA-binding transcription factor activity
THL1_RS08735	COG1278	Cold shock
THL1_RS08745	COG0589	response to stress
THL1_RS08765	COG2249	NAD(P)H dehydrogenase (quinone) activity
THL1_RS08785	COG5265	(ABC) transporter
THL1_RS08800	COG0217	transcriptional regulatory protein
THL1_RS08805	COG3706	GGDEF domain
THL1_RS08815	COG2249	NAD(P)H dehydrogenase (quinone) activity
THL1_RS08820	COG0583	DNA-binding transcription factor activity
THL1_RS08825	COG3257	ureidoglycine aminohydrolase activity
THL1_RS08830	COG0583	DNA-binding transcription factor activity
THL1_RS08855	COG1132	(ABC) transporter
THL1_RS08860	COG3436	PFAM IS66 Orf2 family protein
THL1_RS08870	COG1484	DNA-dependent DNA replication
THL1_RS08875	COG3436	PFAM IS66 Orf2 family protein
THL1_RS08880	COG4372	Transposase
THL1_RS08885	COG4372	Transposase
THL1_RS08890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THL1_RS08895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THL1_RS08895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THL1_RS08900	COG0745	RESPONSE REGULATOR receiver
THL1_RS08905	COG2205	protein histidine kinase activity
THL1_RS08910	COG2977	Belongs to the P-Pant transferase superfamily
THL1_RS08930	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS08935	COG1917	Cupin 2, conserved barrel domain protein
THL1_RS08935	COG4977	sequence-specific DNA binding
THL1_RS08945	COG1960	acyl-CoA dehydrogenase activity
THL1_RS08950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THL1_RS08955	COG3091	SprT-like family
THL1_RS08975	COG2818	Glycosylase
THL1_RS08985	COG0791	NLP P60 protein
THL1_RS08990	COG0791	NLP P60 protein
THL1_RS09015	COG4206	TonB-dependent receptor
THL1_RS09030	COG0778	Nitroreductase
THL1_RS09045	COG1492	cobalamin metabolic process
THL1_RS09065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THL1_RS09070	COG2852	Protein conserved in bacteria
THL1_RS09105	COG0626	cystathionine gamma-synthase activity
THL1_RS09110	COG1522	sequence-specific DNA binding
THL1_RS09120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THL1_RS09135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THL1_RS09175	COG0121	glutamine amidotransferase
THL1_RS09200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THL1_RS09205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THL1_RS09215	COG0697	spore germination
THL1_RS09230	COG0583	DNA-binding transcription factor activity
THL1_RS09235	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
THL1_RS09260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS09265	COG0583	DNA-binding transcription factor activity
THL1_RS09270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THL1_RS09275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THL1_RS09280	COG0235	Class ii aldolase
THL1_RS09285	COG1126	abc transporter atp-binding protein
THL1_RS09290	COG0765	amino acid transport
THL1_RS09295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS09320	COG0840	transmembrane signaling receptor activity
THL1_RS09330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS09335	COG2274	protein secretion by the type I secretion system
THL1_RS09350	COG5001	Diguanylate cyclase
THL1_RS09350	COG3300	MHYT domain
THL1_RS09360	COG2832	Protein of unknown function (DUF454)
THL1_RS09370	COG0514	ATP-dependent DNA helicase (RecQ)
THL1_RS09375	COG5001	Diguanylate cyclase
THL1_RS09375	COG4251	negative regulation of phosphorylation
THL1_RS09375	COG3706	GGDEF domain
THL1_RS09375	COG2203	Gaf domain
THL1_RS09390	COG2814	Major facilitator Superfamily
THL1_RS09400	COG4413	Urea transporter
THL1_RS09405	COG0469	pyruvate kinase activity
THL1_RS09415	COG2084	Dehydrogenase
THL1_RS09420	COG3622	Belongs to the hyi family
THL1_RS09425	COG3960	tartronate-semialdehyde synthase activity
THL1_RS09440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THL1_RS09470	COG2233	PERMEase
THL1_RS09500	COG2252	PERMEase
THL1_RS09505	COG1802	Transcriptional regulator
THL1_RS09510	COG0402	S-adenosylhomocysteine deaminase activity
THL1_RS09535	COG1196	nuclear chromosome segregation
THL1_RS09540	COG3115	cell septum assembly
THL1_RS09545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THL1_RS09575	COG4964	Belongs to the GSP D family
THL1_RS09640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THL1_RS09645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THL1_RS09655	COG1960	acyl-CoA dehydrogenase activity
THL1_RS09660	COG0506	proline dehydrogenase activity
THL1_RS09660	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
THL1_RS09660	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
THL1_RS09670	COG0583	DNA-binding transcription factor activity
THL1_RS09695	COG2271	Major facilitator Superfamily
THL1_RS09700	COG4948	Mandelate Racemase Muconate Lactonizing
THL1_RS09710	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS09725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THL1_RS09745	COG0697	spore germination
THL1_RS09770	COG2072	flavoprotein involved in K transport
THL1_RS09795	COG0776	regulation of translation
THL1_RS09840	COG1216	Glycosyl transferase, family 2
THL1_RS09845	COG0438	transferase activity, transferring glycosyl groups
THL1_RS09850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THL1_RS09860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THL1_RS09870	COG1555	photosystem II stabilization
THL1_RS09880	COG3436	PFAM IS66 Orf2 family protein
THL1_RS09885	COG4372	Transposase
THL1_RS09895	COG3436	PFAM IS66 Orf2 family protein
THL1_RS09915	COG0697	spore germination
THL1_RS09930	COG0583	DNA-binding transcription factor activity
THL1_RS09935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THL1_RS09970	COG1309	transcriptional regulator
THL1_RS09975	COG2267	carboxylic ester hydrolase activity
THL1_RS09980	COG0800	Aldolase
THL1_RS10015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THL1_RS10020	COG0066	3-isopropylmalate dehydratase activity
THL1_RS10025	COG2226	methyltransferase
THL1_RS10095	COG0135	phosphoribosylanthranilate isomerase activity
THL1_RS10105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THL1_RS10110	COG0285	dihydrofolate synthase activity
THL1_RS10120	COG1286	toxin biosynthetic process
THL1_RS10215	COG0446	pyridine nucleotide-disulphide oxidoreductase
THL1_RS10215	COG1902	pentaerythritol trinitrate reductase activity
THL1_RS10230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THL1_RS10230	COG0425	Belongs to the sulfur carrier protein TusA family
THL1_RS10250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THL1_RS10255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THL1_RS10265	COG3139	Protein of unknown function (DUF1315)
THL1_RS10275	COG0308	aminopeptidase N
THL1_RS10325	COG0714	Associated with various cellular activities
THL1_RS10350	COG3130	regulation of translation
THL1_RS10355	COG0116	Belongs to the methyltransferase superfamily
THL1_RS10355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THL1_RS10365	COG2027	D-alanyl-D-alanine carboxypeptidase
THL1_RS10370	COG3171	Protein conserved in bacteria
THL1_RS10375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THL1_RS10375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THL1_RS10380	COG2197	response regulator
THL1_RS10385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS10385	COG2205	protein histidine kinase activity
THL1_RS10400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THL1_RS10405	COG0004	ammonium transporteR
THL1_RS10425	COG0625	glutathione transferase activity
THL1_RS10430	COG1309	transcriptional regulator
THL1_RS10485	COG3311	Transcriptional regulator
THL1_RS10505	COG0582	viral genome integration into host DNA
THL1_RS10520	COG0746	molybdenum cofactor guanylyltransferase activity
THL1_RS10525	COG0521	Mo-molybdopterin cofactor biosynthetic process
THL1_RS10530	COG0303	'Molybdopterin
THL1_RS10550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THL1_RS10575	COG0741	lytic transglycosylase activity
THL1_RS10580	COG0488	(ABC) transporter
THL1_RS10590	COG0589	response to stress
THL1_RS10605	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS10605	COG1024	Enoyl-CoA hydratase
THL1_RS10610	COG0183	Belongs to the thiolase family
THL1_RS10640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THL1_RS10665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THL1_RS10675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THL1_RS10685	COG1113	amino acid transport
THL1_RS10695	COG1805	sodium ion transport
THL1_RS10720	COG1477	protein flavinylation
THL1_RS10730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THL1_RS10735	COG0584	glycerophosphoryl diester phosphodiesterase
THL1_RS10750	COG4591	ABC-type transport system involved in lipoprotein release permease component
THL1_RS10775	COG0811	peptide transport
THL1_RS10780	COG0848	biopolymer transport protein
THL1_RS10785	COG1663	tetraacyldisaccharide 4'-kinase activity
THL1_RS10790	COG2835	tetraacyldisaccharide 4'-kinase activity
THL1_RS10795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THL1_RS10800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THL1_RS10805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THL1_RS10820	COG2084	Dehydrogenase
THL1_RS10850	COG2009	succinate dehydrogenase
THL1_RS10855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
THL1_RS10860	COG1053	succinate dehydrogenase
THL1_RS10865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THL1_RS10885	COG0045	succinate-CoA ligase (ADP-forming) activity
THL1_RS10950	COG1741	Belongs to the pirin family
THL1_RS10970	COG4191	Histidine kinase
THL1_RS10970	COG0784	Response regulator, receiver
THL1_RS10975	COG2020	methyltransferase activity
THL1_RS10985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THL1_RS10990	COG5002	protein histidine kinase activity
THL1_RS10990	COG2205	protein histidine kinase activity
THL1_RS10990	COG0784	Response regulator, receiver
THL1_RS11010	COG1022	Amp-dependent synthetase and ligase
THL1_RS11025	COG1280	lysine exporter protein (LysE YggA)
THL1_RS11045	COG0628	permease
THL1_RS11055	COG0577	efflux transmembrane transporter activity
THL1_RS11080	COG0625	glutathione transferase activity
THL1_RS11085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THL1_RS11085	COG1017	nitric oxide dioxygenase activity
THL1_RS11100	COG0039	L-malate dehydrogenase activity
THL1_RS11120	COG1733	regulation of RNA biosynthetic process
THL1_RS11135	COG0667	Aldo Keto reductase
THL1_RS11165	COG1073	alpha beta
THL1_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS11235	COG2205	protein histidine kinase activity
THL1_RS11240	COG0745	RESPONSE REGULATOR receiver
THL1_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS11285	COG0505	Belongs to the CarA family
THL1_RS11290	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS11295	COG1177	transmembrane transport
THL1_RS11300	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS11305	COG3842	ATPase activity
THL1_RS11310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS11315	COG0450	alkyl hydroperoxide reductase
THL1_RS11320	COG2308	Evidence 4 Homologs of previously reported genes of
THL1_RS11330	COG1305	Transglutaminase-like
THL1_RS11350	COG0183	Belongs to the thiolase family
THL1_RS11355	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS11355	COG1024	Enoyl-CoA hydratase
THL1_RS11375	COG0519	Catalyzes the synthesis of GMP from XMP
THL1_RS11380	COG0598	Magnesium transport protein CorA
THL1_RS11400	COG1960	acyl-CoA dehydrogenase activity
THL1_RS11405	COG1024	Enoyl-CoA hydratase
THL1_RS11415	COG1024	Enoyl-CoA hydratase
THL1_RS11425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THL1_RS11435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THL1_RS11440	COG3162	membrane
THL1_RS11445	COG0583	DNA-binding transcription factor activity
THL1_RS11450	COG0446	pyridine nucleotide-disulphide oxidoreductase
THL1_RS11450	COG1902	pentaerythritol trinitrate reductase activity
THL1_RS11455	COG0789	Transcriptional regulator
THL1_RS11465	COG3108	Peptidase M15
THL1_RS11475	COG0840	transmembrane signaling receptor activity
THL1_RS11500	COG1846	Transcriptional regulator
THL1_RS11510	COG0583	DNA-binding transcription factor activity
THL1_RS11520	COG0583	DNA-binding transcription factor activity
THL1_RS11535	COG3214	Protein conserved in bacteria
THL1_RS11540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
THL1_RS11565	COG3384	dioxygenase
THL1_RS11570	COG0500	methyltransferase
THL1_RS11585	COG0436	Aminotransferase
THL1_RS11595	COG0386	Belongs to the glutathione peroxidase family
THL1_RS11600	COG1846	Transcriptional regulator
THL1_RS11605	COG2205	protein histidine kinase activity
THL1_RS11605	COG5002	protein histidine kinase activity
THL1_RS11605	COG0784	Response regulator, receiver
THL1_RS11615	COG1956	GAF domain-containing protein
THL1_RS11620	COG0625	glutathione transferase activity
THL1_RS11675	COG1595	DNA-templated transcription, initiation
THL1_RS11685	COG0714	Associated with various cellular activities
THL1_RS11720	COG0084	hydrolase, TatD family'
THL1_RS11725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THL1_RS11730	COG2259	Doxx family
THL1_RS11745	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THL1_RS11760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THL1_RS11765	COG4181	ATPase activity
THL1_RS11780	COG1376	ErfK ybiS ycfS ynhG family protein
THL1_RS11815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
THL1_RS11855	COG2909	trisaccharide binding
THL1_RS11860	COG2909	trisaccharide binding
THL1_RS11915	COG0840	transmembrane signaling receptor activity
THL1_RS11925	COG0745	RESPONSE REGULATOR receiver
THL1_RS11935	COG3204	pilus organization
THL1_RS11940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THL1_RS11945	COG0463	Glycosyl transferase, family 2
THL1_RS11970	COG2198	Histidine kinase
THL1_RS11970	COG2205	protein histidine kinase activity
THL1_RS11970	COG0784	Response regulator, receiver
THL1_RS11975	COG2194	sulfuric ester hydrolase activity
THL1_RS12000	COG0625	glutathione transferase activity
THL1_RS12040	COG0604	alcohol dehydrogenase
THL1_RS12045	COG2207	Transcriptional regulator
THL1_RS12090	COG2866	Carboxypeptidase
THL1_RS12095	COG1045	serine acetyltransferase
THL1_RS12135	COG0753	catalase activity
THL1_RS12150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THL1_RS12165	COG0686	Belongs to the AlaDH PNT family
THL1_RS12170	COG0330	HflC and HflK could
THL1_RS12190	COG2010	Cytochrome c
THL1_RS12210	COG0840	transmembrane signaling receptor activity
THL1_RS12215	COG2056	Na+-H+ antiporter family
THL1_RS12240	COG1007	ATP synthesis coupled electron transport
THL1_RS12255	COG0713	ATP synthesis coupled electron transport
THL1_RS12270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THL1_RS12290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THL1_RS12290	COG0649	NAD binding
THL1_RS12295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THL1_RS12300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THL1_RS12330	COG2153	protein acetylation
THL1_RS12335	COG2850	peptidyl-arginine hydroxylation
THL1_RS12350	COG0482	sulfurtransferase activity
THL1_RS12370	COG1278	Cold shock
THL1_RS12375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THL1_RS12380	COG0542	response to heat
THL1_RS12385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THL1_RS12390	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THL1_RS12395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THL1_RS12400	COG0492	ferredoxin-NADP+ reductase activity
THL1_RS12410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THL1_RS12415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THL1_RS12420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THL1_RS12425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THL1_RS12430	COG1648	precorrin-2 dehydrogenase activity
THL1_RS12430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THL1_RS12435	COG0435	Glutathione S-transferase
THL1_RS12440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THL1_RS12575	COG1942	4-Oxalocrotonate Tautomerase
THL1_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS12585	COG0583	DNA-binding transcription factor activity
THL1_RS12595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
THL1_RS12600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
THL1_RS12605	COG0183	Belongs to the thiolase family
THL1_RS12615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THL1_RS12620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
THL1_RS12625	COG1053	succinate dehydrogenase
THL1_RS12645	COG0697	spore germination
THL1_RS12660	COG0477	Major facilitator Superfamily
THL1_RS12665	COG1082	Xylose isomerase domain protein TIM barrel
THL1_RS12665	COG3185	4-Hydroxyphenylpyruvate dioxygenase
THL1_RS12670	COG1309	transcriptional regulator
THL1_RS12675	COG1053	succinate dehydrogenase
THL1_RS12685	COG1053	succinate dehydrogenase
THL1_RS12690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THL1_RS12695	COG1414	Transcriptional regulator
THL1_RS12700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THL1_RS12705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THL1_RS12755	COG1566	PFAM secretion protein HlyD family protein
THL1_RS12815	COG3300	MHYT domain
THL1_RS12815	COG5001	Diguanylate cyclase
THL1_RS12880	COG3781	membrane
THL1_RS12885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THL1_RS12890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THL1_RS12920	COG2072	flavoprotein involved in K transport
THL1_RS12935	COG0640	Transcriptional regulator
THL1_RS12940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THL1_RS12945	COG0798	PFAM Bile acid sodium symporter
THL1_RS12950	COG0431	NADPH-dependent FMN reductase
THL1_RS12960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THL1_RS12990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THL1_RS13000	COG3158	transport of potassium into the cell
THL1_RS13005	COG0826	peptidase U32
THL1_RS13030	COG1522	sequence-specific DNA binding
THL1_RS13035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THL1_RS13045	COG3706	GGDEF domain
THL1_RS13045	COG2203	Gaf domain
THL1_RS13045	COG4251	negative regulation of phosphorylation
THL1_RS13045	COG5001	Diguanylate cyclase
THL1_RS13055	COG0446	pyridine nucleotide-disulphide oxidoreductase
THL1_RS13100	COG1116	anion transmembrane transporter activity
THL1_RS13110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THL1_RS13135	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
THL1_RS13150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THL1_RS13155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS13170	COG0789	Transcriptional regulator
THL1_RS13200	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS13260	COG1538	Outer membrane efflux protein
THL1_RS13270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THL1_RS13295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THL1_RS13305	COG3220	belongs to the UPF0276 family
THL1_RS13305	COG3220	belongs to the UPF0276 family
THL1_RS13385	COG1764	response to oxidative stress
THL1_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS13400	COG3239	Fatty acid desaturase
THL1_RS13415	COG3415	Transposase
THL1_RS13415	COG2801	Transposase and inactivated derivatives
THL1_RS13420	COG0417	DNA replication proofreading
THL1_RS13450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THL1_RS13455	COG0583	DNA-binding transcription factor activity
THL1_RS13460	COG2233	PERMEase
THL1_RS13485	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS13495	COG0154	amidase activity
THL1_RS13510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THL1_RS13525	COG0642	Histidine kinase
THL1_RS13530	COG0210	DNA helicase
THL1_RS13535	COG3265	gluconokinase activity
THL1_RS13555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
THL1_RS13570	COG0154	amidase activity
THL1_RS13580	COG1177	transmembrane transport
THL1_RS13585	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS13595	COG0583	DNA-binding transcription factor activity
THL1_RS13600	COG1984	allophanate hydrolase subunit 2
THL1_RS13605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THL1_RS13615	COG2814	Major facilitator Superfamily
THL1_RS13620	COG0583	DNA-binding transcription factor activity
THL1_RS13660	COG5383	Protein conserved in bacteria
THL1_RS13670	COG0277	FAD linked oxidase domain protein
THL1_RS13670	COG0247	lactate metabolic process
THL1_RS13675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THL1_RS13680	COG0583	DNA-binding transcription factor activity
THL1_RS13685	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS13690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS13700	COG3971	2-oxopent-4-enoate hydratase activity
THL1_RS13710	COG3384	dioxygenase
THL1_RS13715	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS13805	COG0531	amino acid
THL1_RS13815	COG1846	Transcriptional regulator
THL1_RS13820	COG1960	acyl-CoA dehydrogenase activity
THL1_RS13825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THL1_RS13830	COG5002	protein histidine kinase activity
THL1_RS13835	COG0789	Transcriptional regulator
THL1_RS13860	COG4772	TonB-dependent receptor
THL1_RS13865	COG2079	MmgE PrpD family protein
THL1_RS13885	COG2175	clavaminate synthase activity
THL1_RS13890	COG3246	L-lysine catabolic process to acetate
THL1_RS13895	COG2271	Major facilitator Superfamily
THL1_RS13915	COG2207	Transcriptional regulator
THL1_RS13940	COG4447	cellulose binding
THL1_RS13955	COG1566	PFAM secretion protein HlyD family protein
THL1_RS13985	COG5001	Diguanylate cyclase
THL1_RS13985	COG4251	negative regulation of phosphorylation
THL1_RS13985	COG2203	Gaf domain
THL1_RS13985	COG3706	GGDEF domain
THL1_RS14000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THL1_RS14010	COG1609	Transcriptional regulator
THL1_RS14015	COG0583	DNA-binding transcription factor activity
THL1_RS14020	COG0235	Class ii aldolase
THL1_RS14025	COG1177	transmembrane transport
THL1_RS14040	COG3842	ATPase activity
THL1_RS14050	COG1473	amidohydrolase
THL1_RS14060	COG0523	cobalamin synthesis protein
THL1_RS14090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THL1_RS14095	COG1760	l-serine dehydratase
THL1_RS14100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THL1_RS14100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THL1_RS14105	COG0509	glycine decarboxylation via glycine cleavage system
THL1_RS14140	COG2205	protein histidine kinase activity
THL1_RS14140	COG0784	Response regulator, receiver
THL1_RS14145	COG1943	Transposase
THL1_RS14170	COG1999	signal sequence binding
THL1_RS14185	COG1131	(ABC) transporter
THL1_RS14200	COG3851	Histidine kinase
THL1_RS14260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THL1_RS14265	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
THL1_RS14275	COG0535	radical SAM domain protein
THL1_RS14295	COG4178	(ABC) transporter
THL1_RS14315	COG2259	Doxx family
THL1_RS14325	COG3220	belongs to the UPF0276 family
THL1_RS14340	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS14350	COG0583	DNA-binding transcription factor activity
THL1_RS14355	COG3485	protocatechuate 3,4-dioxygenase
THL1_RS14360	COG3485	protocatechuate 3,4-dioxygenase
THL1_RS14365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THL1_RS14370	COG0679	Auxin Efflux Carrier
THL1_RS14375	COG1414	Transcriptional regulator
THL1_RS14410	COG2814	Major facilitator Superfamily
THL1_RS14415	COG3135	benzoate transporter
THL1_RS14430	COG0604	alcohol dehydrogenase
THL1_RS14435	COG1309	transcriptional regulator
THL1_RS14440	COG3415	Transposase
THL1_RS14440	COG2801	Transposase and inactivated derivatives
THL1_RS14445	COG1959	2 iron, 2 sulfur cluster binding
THL1_RS14465	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS14480	COG0583	DNA-binding transcription factor activity
THL1_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS14495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THL1_RS14505	COG0861	Integral membrane protein TerC family
THL1_RS14510	COG3284	Transcriptional regulator
THL1_RS14530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THL1_RS14535	COG0022	dehydrogenase e1 component
THL1_RS14545	COG0508	dehydrogenase complex catalyzes the overall conversion of
THL1_RS14560	COG0583	DNA-binding transcription factor activity
THL1_RS14565	COG2957	Belongs to the agmatine deiminase family
THL1_RS14570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THL1_RS14580	COG2957	Belongs to the agmatine deiminase family
THL1_RS14585	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS14595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THL1_RS14600	COG0583	DNA-binding transcription factor activity
THL1_RS14605	COG4638	Rieske (2fe-2S)
THL1_RS14620	COG4176	ABC-type proline glycine betaine transport system permease component
THL1_RS14625	COG2113	Glycine betaine
THL1_RS14635	COG4977	sequence-specific DNA binding
THL1_RS14640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THL1_RS14645	COG0785	Cytochrome C biogenesis protein
THL1_RS14665	COG1737	Transcriptional regulator
THL1_RS14695	COG3046	protein related to deoxyribodipyrimidine photolyase
THL1_RS14705	COG0583	DNA-binding transcription factor activity
THL1_RS14710	COG0477	Major facilitator Superfamily
THL1_RS14715	COG0235	Class ii aldolase
THL1_RS14720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THL1_RS14730	COG0477	Major facilitator Superfamily
THL1_RS14740	COG0251	oxidation-reduction process
THL1_RS14745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THL1_RS14750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS15295	COG3415	Transposase
THL1_RS15295	COG2801	Transposase and inactivated derivatives
THL1_RS15310	COG0523	cobalamin synthesis protein
THL1_RS15315	COG2879	small protein
THL1_RS15320	COG1966	Carbon starvation protein
THL1_RS15365	COG1280	lysine exporter protein (LysE YggA)
THL1_RS15395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THL1_RS15415	COG3530	Putative quorum-sensing-regulated virulence factor
THL1_RS15430	COG2807	transmembrane transport
THL1_RS15435	COG0590	tRNA wobble adenosine to inosine editing
THL1_RS15440	COG0583	DNA-binding transcription factor activity
THL1_RS15460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS15520	COG2409	Drug exporters of the RND superfamily
THL1_RS15540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS15550	COG0729	surface antigen
THL1_RS15560	COG0708	Exodeoxyribonuclease III
THL1_RS15575	COG0861	Integral membrane protein TerC family
THL1_RS15580	COG1960	acyl-CoA dehydrogenase activity
THL1_RS15590	COG1024	Enoyl-CoA hydratase
THL1_RS15595	COG1960	acyl-CoA dehydrogenase activity
THL1_RS15610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THL1_RS15615	COG0840	transmembrane signaling receptor activity
THL1_RS15625	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS15665	COG0174	glutamine synthetase
THL1_RS15670	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS15675	COG2207	Transcriptional regulator
THL1_RS15680	COG3327	negative regulation of DNA-templated transcription, initiation
THL1_RS15695	COG1024	Enoyl-CoA hydratase
THL1_RS15700	COG1024	Enoyl-CoA hydratase
THL1_RS15705	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS15710	COG2050	protein possibly involved in aromatic compounds catabolism
THL1_RS15715	COG0183	Belongs to the thiolase family
THL1_RS15735	COG5507	3-demethylubiquinone-9 3-methyltransferase
THL1_RS15740	COG3396	Phenylacetate-CoA oxygenase
THL1_RS15745	COG3460	Phenylacetate-CoA oxygenase
THL1_RS15750	COG3396	Phenylacetate-CoA oxygenase
THL1_RS15755	COG2151	metal-sulfur cluster biosynthetic enzyme
THL1_RS15760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THL1_RS15780	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS15780	COG2030	dehydratase
THL1_RS15790	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
THL1_RS15795	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THL1_RS15805	COG1301	dicarboxylic acid transport
THL1_RS15810	COG0583	DNA-binding transcription factor activity
THL1_RS15850	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS15860	COG1404	Belongs to the peptidase S8 family
THL1_RS15865	COG1132	(ABC) transporter
THL1_RS15875	COG0789	Transcriptional regulator
THL1_RS15880	COG1960	acyl-CoA dehydrogenase activity
THL1_RS15885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THL1_RS15890	COG1024	Enoyl-CoA hydratase
THL1_RS15905	COG2031	fatty acid transporter
THL1_RS15915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
THL1_RS15920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
THL1_RS15925	COG0583	DNA-binding transcription factor activity
THL1_RS15930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THL1_RS15945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THL1_RS15960	COG0488	(ABC) transporter
THL1_RS15965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
THL1_RS16000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THL1_RS16010	COG0842	Transport permease protein
THL1_RS16015	COG1131	(ABC) transporter
THL1_RS16030	COG3415	Transposase
THL1_RS16030	COG2801	Transposase and inactivated derivatives
THL1_RS16035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THL1_RS16050	COG3617	BRO family, N-terminal domain
THL1_RS16055	COG4372	Transposase
THL1_RS16080	COG4695	Portal protein
THL1_RS16200	COG3668	Plasmid stabilization system
THL1_RS16235	COG3436	PFAM IS66 Orf2 family protein
THL1_RS16240	COG4372	Transposase
THL1_RS16250	COG2944	sequence-specific DNA binding
THL1_RS16345	COG0735	belongs to the Fur family
THL1_RS16350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THL1_RS16360	COG0745	RESPONSE REGULATOR receiver
THL1_RS16370	COG2853	Lipoprotein
THL1_RS16390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THL1_RS16390	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THL1_RS16395	COG4942	peptidase
THL1_RS16415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THL1_RS16430	COG0697	spore germination
THL1_RS16470	COG1177	transmembrane transport
THL1_RS16475	COG3842	ATPase activity
THL1_RS16480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS16485	COG4948	Mandelate Racemase Muconate Lactonizing
THL1_RS16490	COG1802	Transcriptional regulator
THL1_RS16495	COG0840	transmembrane signaling receptor activity
THL1_RS16500	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS16515	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS16520	COG2223	nitrite transmembrane transporter activity
THL1_RS16525	COG1802	Transcriptional regulator
THL1_RS16540	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
THL1_RS16545	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS16550	COG0842	Transport permease protein
THL1_RS16555	COG1131	(ABC) transporter
THL1_RS16570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS16585	COG0653	protein targeting
THL1_RS16595	COG1484	DNA-dependent DNA replication
THL1_RS16625	COG2274	protein secretion by the type I secretion system
THL1_RS16655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THL1_RS16670	COG4372	Transposase
THL1_RS16730	COG1968	undecaprenyl-diphosphatase activity
THL1_RS16790	COG3604	Transcriptional regulator
THL1_RS16795	COG0720	synthase
THL1_RS16880	COG0659	secondary active sulfate transmembrane transporter activity
THL1_RS16895	COG0589	response to stress
THL1_RS16925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THL1_RS16930	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS16945	COG3180	Ammonia monooxygenase
THL1_RS16950	COG0861	Integral membrane protein TerC family
THL1_RS16960	COG2851	Citrate transporter
THL1_RS16965	COG2828	Protein conserved in bacteria
THL1_RS16970	COG0583	DNA-binding transcription factor activity
THL1_RS16975	COG2204	response regulator
THL1_RS16985	COG2610	gluconate transmembrane transporter activity
THL1_RS16990	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS17010	COG3177	Filamentation induced by cAMP protein fic
THL1_RS17025	COG1192	Involved in chromosome partitioning
THL1_RS17050	COG0156	8-amino-7-oxononanoate synthase activity
THL1_RS17065	COG0367	asparagine synthase
THL1_RS17075	COG0583	DNA-binding transcription factor activity
THL1_RS17085	COG0251	oxidation-reduction process
THL1_RS17100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS17120	COG1231	oxidoreductase activity
THL1_RS17175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS17180	COG3321	synthase
THL1_RS17180	COG4221	oxidoreductase activity
THL1_RS17180	COG0300	oxidoreductase activity
THL1_RS17180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THL1_RS17185	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS17200	COG1917	Cupin 2, conserved barrel domain protein
THL1_RS17200	COG4977	sequence-specific DNA binding
THL1_RS17205	COG0183	Belongs to the thiolase family
THL1_RS17215	COG1960	acyl-CoA dehydrogenase activity
THL1_RS17220	COG5001	Diguanylate cyclase
THL1_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS17265	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS17265	COG1024	Enoyl-CoA hydratase
THL1_RS17290	COG4962	Type ii secretion system protein e
THL1_RS17305	COG3451	type IV secretory pathway VirB4
THL1_RS17320	COG3846	protein secretion by the type IV secretion system
THL1_RS17370	COG3842	ATPase activity
THL1_RS17380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THL1_RS17390	COG1454	alcohol dehydrogenase
THL1_RS17395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THL1_RS17400	COG0583	DNA-binding transcription factor activity
THL1_RS17415	COG1960	acyl-CoA dehydrogenase activity
THL1_RS17420	COG0183	Belongs to the thiolase family
THL1_RS17425	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS17445	COG1960	acyl-CoA dehydrogenase activity
THL1_RS17450	COG1024	Enoyl-CoA hydratase
THL1_RS17455	COG1024	Enoyl-CoA hydratase
THL1_RS17460	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS17465	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS17470	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
THL1_RS17475	COG1960	acyl-CoA dehydrogenase activity
THL1_RS17480	COG1846	Transcriptional regulator
THL1_RS17520	COG1309	transcriptional regulator
THL1_RS17530	COG1484	DNA-dependent DNA replication
THL1_RS17565	COG0776	regulation of translation
THL1_RS17570	COG0072	phenylalanine-tRNA ligase activity
THL1_RS17575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THL1_RS17580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THL1_RS17585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THL1_RS17710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS17730	COG3813	Protein conserved in bacteria
THL1_RS17735	COG0316	Belongs to the HesB IscA family
THL1_RS17735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THL1_RS17760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THL1_RS17795	COG0616	signal peptide processing
THL1_RS17800	COG0406	alpha-ribazole phosphatase activity
THL1_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS17840	COG1024	Enoyl-CoA hydratase
THL1_RS17845	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THL1_RS17850	COG0531	amino acid
THL1_RS17890	COG0477	Major facilitator Superfamily
THL1_RS17900	COG0328	RNA-DNA hybrid ribonuclease activity
THL1_RS17915	COG1388	LysM domain
THL1_RS17915	COG0741	lytic transglycosylase activity
THL1_RS17930	COG4166	transmembrane transport
THL1_RS17935	COG4166	transmembrane transport
THL1_RS17940	COG4174	ABC transporter (Permease)
THL1_RS17945	COG4239	(ABC) transporter, permease
THL1_RS17950	COG4172	Belongs to the ABC transporter superfamily
THL1_RS17960	COG4372	Transposase
THL1_RS17975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THL1_RS17985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THL1_RS18000	COG0544	peptidyl-prolyl cis-trans isomerase activity
THL1_RS18030	COG0215	cysteine-tRNA ligase activity
THL1_RS18040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THL1_RS18055	COG0589	response to stress
THL1_RS18075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THL1_RS18085	COG0436	Aminotransferase
THL1_RS18105	COG2223	nitrite transmembrane transporter activity
THL1_RS18110	COG2815	serine threonine protein kinase
THL1_RS18110	COG0515	serine threonine protein kinase
THL1_RS18115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THL1_RS18135	COG0668	transmembrane transport
THL1_RS18150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THL1_RS18165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
THL1_RS18190	COG1802	Transcriptional regulator
THL1_RS18195	COG0189	ligase activity
THL1_RS18195	COG4067	protein conserved in archaea
THL1_RS18220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THL1_RS18245	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
THL1_RS18250	COG0235	Class ii aldolase
THL1_RS18260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THL1_RS18265	COG1073	alpha beta
THL1_RS18300	COG0625	glutathione transferase activity
THL1_RS18305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THL1_RS18325	COG3135	benzoate transporter
THL1_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS18335	COG2130	NADP-dependent
THL1_RS18350	COG0583	DNA-binding transcription factor activity
THL1_RS18375	COG1309	transcriptional regulator
THL1_RS18390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THL1_RS18395	COG1960	acyl-CoA dehydrogenase activity
THL1_RS18400	COG1024	Enoyl-CoA hydratase
THL1_RS18415	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS18430	COG1595	DNA-templated transcription, initiation
THL1_RS18435	COG2304	oxidoreductase activity
THL1_RS18440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THL1_RS18445	COG2885	chlorophyll binding
THL1_RS18460	COG2267	carboxylic ester hydrolase activity
THL1_RS18490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THL1_RS18505	COG0084	hydrolase, TatD family'
THL1_RS18585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THL1_RS18625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THL1_RS18630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THL1_RS18640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THL1_RS18645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THL1_RS18660	COG0416	fatty acid biosynthetic process
THL1_RS18665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THL1_RS18675	COG0424	maF-like protein
THL1_RS18685	COG0546	phosphoglycolate phosphatase activity
THL1_RS18695	COG1530	ribonuclease E activity
THL1_RS18700	COG1132	(ABC) transporter
THL1_RS18705	COG3011	Protein conserved in bacteria
THL1_RS18715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THL1_RS18725	COG3415	Transposase
THL1_RS18725	COG2801	Transposase and inactivated derivatives
THL1_RS18745	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
THL1_RS18770	COG3420	alginic acid biosynthetic process
THL1_RS18800	COG0840	transmembrane signaling receptor activity
THL1_RS18810	COG3278	Belongs to the heme-copper respiratory oxidase family
THL1_RS18830	COG3278	Belongs to the heme-copper respiratory oxidase family
THL1_RS18845	COG2010	Cytochrome c
THL1_RS18850	COG0348	domain, Protein
THL1_RS18880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THL1_RS18885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THL1_RS18925	COG2204	response regulator
THL1_RS18960	COG0765	amino acid transport
THL1_RS18965	COG0765	amino acid transport
THL1_RS18970	COG1126	abc transporter atp-binding protein
THL1_RS18995	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS19000	COG0583	DNA-binding transcription factor activity
THL1_RS19005	COG2807	transmembrane transport
THL1_RS19020	COG0531	amino acid
THL1_RS19030	COG2169	Transcriptional regulator
THL1_RS19030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THL1_RS19040	COG0583	DNA-binding transcription factor activity
THL1_RS19055	COG4221	oxidoreductase activity
THL1_RS19065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THL1_RS19075	COG1113	amino acid transport
THL1_RS19085	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS19105	COG4628	conserved protein (DUF2132)
THL1_RS19110	COG4991	sh3 domain protein
THL1_RS19115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THL1_RS19130	COG0583	DNA-binding transcription factor activity
THL1_RS19135	COG0583	DNA-binding transcription factor activity
THL1_RS19150	COG0477	Major facilitator Superfamily
THL1_RS19155	COG0583	DNA-binding transcription factor activity
THL1_RS19160	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS19170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THL1_RS19180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THL1_RS19195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THL1_RS19205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THL1_RS19210	COG0402	S-adenosylhomocysteine deaminase activity
THL1_RS19215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THL1_RS19220	COG0546	phosphoglycolate phosphatase activity
THL1_RS19225	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS19240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THL1_RS19255	COG0009	L-threonylcarbamoyladenylate synthase
THL1_RS19260	COG0613	PHP domain protein
THL1_RS19265	COG2917	probably involved in intracellular septation
THL1_RS19270	COG2350	Protein conserved in bacteria
THL1_RS19280	COG0745	RESPONSE REGULATOR receiver
THL1_RS19285	COG3678	ATP-independent chaperone mediated protein folding
THL1_RS19295	COG0778	Nitroreductase
THL1_RS19300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THL1_RS19305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THL1_RS19340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THL1_RS19355	COG1752	Esterase of the alpha-beta hydrolase superfamily
THL1_RS19360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
THL1_RS19420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THL1_RS19450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THL1_RS19465	COG0835	chemotaxis
THL1_RS19475	COG1192	Involved in chromosome partitioning
THL1_RS19480	COG1360	Flagellar Motor Protein
THL1_RS19485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THL1_RS19490	COG2201	protein-glutamate methylesterase activity
THL1_RS19495	COG2198	Histidine kinase
THL1_RS19495	COG0784	Response regulator, receiver
THL1_RS19495	COG0643	Histidine kinase
THL1_RS19525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THL1_RS19540	COG1987	bacterial-type flagellum assembly
THL1_RS19580	COG0745	RESPONSE REGULATOR receiver
THL1_RS19590	COG2882	bacterial-type flagellum organization
THL1_RS19645	COG1516	flagellar protein fliS
THL1_RS19650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THL1_RS19695	COG4787	bacterial-type flagellum-dependent cell motility
THL1_RS19700	COG3415	Transposase
THL1_RS19700	COG2801	Transposase and inactivated derivatives
THL1_RS19705	COG1749	Flagellar hook protein flgE
THL1_RS19710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THL1_RS19720	COG1815	bacterial-type flagellum-dependent cell motility
THL1_RS19725	COG2249	NAD(P)H dehydrogenase (quinone) activity
THL1_RS19735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THL1_RS19745	COG0747	negative chemotaxis
THL1_RS19750	COG1959	2 iron, 2 sulfur cluster binding
THL1_RS19780	COG1960	acyl-CoA dehydrogenase activity
THL1_RS19785	COG1024	Enoyl-CoA hydratase
THL1_RS19790	COG0833	amino acid
THL1_RS19815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS19830	COG1764	response to oxidative stress
THL1_RS19835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THL1_RS19840	COG0835	chemotaxis
THL1_RS19840	COG0784	Response regulator, receiver
THL1_RS19860	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
THL1_RS19870	COG0477	Major facilitator Superfamily
THL1_RS19910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THL1_RS19910	COG2146	nitrite reductase [NAD(P)H] activity
THL1_RS19915	COG0243	molybdopterin cofactor binding
THL1_RS19945	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS19950	COG1335	isochorismatase
THL1_RS19975	COG2814	Major facilitator Superfamily
THL1_RS19980	COG0583	DNA-binding transcription factor activity
THL1_RS19985	COG1368	sulfuric ester hydrolase activity
THL1_RS20000	COG1595	DNA-templated transcription, initiation
THL1_RS20020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THL1_RS20040	COG4221	oxidoreductase activity
THL1_RS20055	COG0642	Histidine kinase
THL1_RS20060	COG0642	Histidine kinase
THL1_RS20065	COG0745	RESPONSE REGULATOR receiver
THL1_RS20080	COG1230	cation diffusion facilitator family transporter
THL1_RS20095	COG4191	Histidine kinase
THL1_RS20095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS20110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
THL1_RS20115	COG0179	Fumarylacetoacetate (FAA) hydrolase
THL1_RS20135	COG2239	Acts as a magnesium transporter
THL1_RS20150	COG4941	Belongs to the sigma-70 factor family
THL1_RS20155	COG3795	YCII-related domain
THL1_RS20170	COG0504	CTP synthase activity
THL1_RS20175	COG2329	Antibiotic biosynthesis monooxygenase
THL1_RS20205	COG0537	adenosine 5'-monophosphoramidase activity
THL1_RS20215	COG1643	Atp-dependent helicase
THL1_RS20220	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS20225	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS20240	COG2030	dehydratase
THL1_RS20245	COG1566	PFAM secretion protein HlyD family protein
THL1_RS20255	COG1289	transmembrane transporter activity
THL1_RS20270	COG1131	(ABC) transporter
THL1_RS20275	COG0842	Transport permease protein
THL1_RS20280	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS20290	COG1840	ABC-type Fe3 transport system, periplasmic component
THL1_RS20295	COG1178	ABC-type Fe3 transport system permease component
THL1_RS20300	COG3842	ATPase activity
THL1_RS20375	COG0582	viral genome integration into host DNA
THL1_RS20405	COG5001	Diguanylate cyclase
THL1_RS20435	COG0840	transmembrane signaling receptor activity
THL1_RS20455	COG1024	Enoyl-CoA hydratase
THL1_RS20460	COG1960	acyl-CoA dehydrogenase activity
THL1_RS20520	COG1024	Enoyl-CoA hydratase
THL1_RS20525	COG0439	Biotin carboxylase
THL1_RS20540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THL1_RS20560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THL1_RS20575	COG3321	synthase
THL1_RS20575	COG0604	alcohol dehydrogenase
THL1_RS20575	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS20580	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
THL1_RS20630	COG3039	Transposase
THL1_RS20640	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS20645	COG0183	Belongs to the thiolase family
THL1_RS20650	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS20655	COG1024	Enoyl-CoA hydratase
THL1_RS20670	COG1309	transcriptional regulator
THL1_RS20680	COG1845	cytochrome c oxidase, subunit III
THL1_RS20770	COG0640	Transcriptional regulator
THL1_RS20775	COG3453	Protein conserved in bacteria
THL1_RS20775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THL1_RS20830	COG1024	Enoyl-CoA hydratase
THL1_RS20830	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS20835	COG0183	Belongs to the thiolase family
THL1_RS20840	COG2909	trisaccharide binding
THL1_RS20845	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS20870	COG1309	transcriptional regulator
THL1_RS20880	COG0633	Ferredoxin
THL1_RS20890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THL1_RS20905	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
THL1_RS20910	COG1250	3-hydroxyacyl-CoA dehydrogenase
THL1_RS20915	COG1024	Enoyl-CoA hydratase
THL1_RS20920	COG1024	Enoyl-CoA hydratase
THL1_RS20925	COG0183	Belongs to the thiolase family
THL1_RS20940	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS20945	COG1024	Enoyl-CoA hydratase
THL1_RS20975	COG1773	rubredoxin
THL1_RS21015	COG1309	transcriptional regulator
THL1_RS21025	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS21035	COG2365	Tyrosine phosphatase family
THL1_RS21110	COG1522	sequence-specific DNA binding
THL1_RS21115	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
THL1_RS21125	COG2239	Acts as a magnesium transporter
THL1_RS21150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THL1_RS21155	COG0527	aspartate kinase activity
THL1_RS21160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THL1_RS21170	COG2988	succinylglutamate desuccinylase activity
THL1_RS21185	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS21240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THL1_RS21250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THL1_RS21270	COG4106	trans-aconitate 2-methyltransferase activity
THL1_RS21275	COG0500	methyltransferase
THL1_RS21290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THL1_RS21295	COG0571	ribonuclease III activity
THL1_RS21315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THL1_RS21430	COG1024	Enoyl-CoA hydratase
THL1_RS21445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS21470	COG3300	MHYT domain
THL1_RS21470	COG5001	Diguanylate cyclase
THL1_RS21485	COG2015	COG2015, Alkyl sulfatase and related hydrolases
THL1_RS21510	COG1116	anion transmembrane transporter activity
THL1_RS21525	COG0439	Biotin carboxylase
THL1_RS21545	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THL1_RS21560	COG0346	lactoylglutathione lyase activity
THL1_RS21565	COG0137	argininosuccinate synthase activity
THL1_RS21575	COG0418	dihydroorotase activity
THL1_RS21585	COG0450	alkyl hydroperoxide reductase
THL1_RS21600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
THL1_RS21605	COG0243	molybdopterin cofactor binding
THL1_RS21615	COG2203	Gaf domain
THL1_RS21615	COG3706	GGDEF domain
THL1_RS21615	COG4251	negative regulation of phosphorylation
THL1_RS21615	COG5001	Diguanylate cyclase
THL1_RS21625	COG3842	ATPase activity
THL1_RS21635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THL1_RS21665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THL1_RS21670	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS21675	COG0010	Belongs to the arginase family
THL1_RS21690	COG0509	glycine decarboxylation via glycine cleavage system
THL1_RS21695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THL1_RS21695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THL1_RS21700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THL1_RS21705	COG1760	l-serine dehydratase
THL1_RS21710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THL1_RS21715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THL1_RS21720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THL1_RS21725	COG0583	DNA-binding transcription factor activity
THL1_RS21780	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS21800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THL1_RS21805	COG1960	acyl-CoA dehydrogenase activity
THL1_RS21825	COG0450	alkyl hydroperoxide reductase
THL1_RS21835	COG1201	RNA secondary structure unwinding
THL1_RS21845	COG1611	Belongs to the LOG family
THL1_RS21855	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS21870	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
THL1_RS21875	COG4638	Rieske (2fe-2S)
THL1_RS21885	COG2801	Transposase and inactivated derivatives
THL1_RS21885	COG3415	Transposase
THL1_RS21920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THL1_RS21930	COG0587	DNA-directed DNA polymerase activity
THL1_RS21945	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS22025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THL1_RS22030	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
THL1_RS22035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THL1_RS22045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THL1_RS22055	COG0425	Belongs to the sulfur carrier protein TusA family
THL1_RS22065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THL1_RS22075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THL1_RS22080	COG0602	queuosine metabolic process
THL1_RS22085	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
THL1_RS22090	COG2885	chlorophyll binding
THL1_RS22115	COG0824	Thioesterase
THL1_RS22120	COG2255	four-way junction helicase activity
THL1_RS22130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THL1_RS22150	COG0783	Belongs to the Dps family
THL1_RS22155	COG3706	GGDEF domain
THL1_RS22165	COG2900	Belongs to the SlyX family
THL1_RS22185	COG0442	prolyl-tRNA aminoacylation
THL1_RS22240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THL1_RS22245	COG0628	permease
THL1_RS22265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THL1_RS22280	COG3122	Protein conserved in bacteria
THL1_RS22285	COG3956	TIGRFAM MazG family protein
THL1_RS22290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THL1_RS22295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THL1_RS22315	COG2205	protein histidine kinase activity
THL1_RS22315	COG5002	protein histidine kinase activity
THL1_RS22315	COG0784	Response regulator, receiver
THL1_RS22320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THL1_RS22335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THL1_RS22365	COG3038	cytochrome b561
THL1_RS22375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THL1_RS22420	COG0583	DNA-binding transcription factor activity
THL1_RS22440	COG3148	PFAM DTW domain containing protein
THL1_RS22465	COG1546	Belongs to the CinA family
THL1_RS22495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THL1_RS22505	COG0585	pseudouridine synthase activity
THL1_RS22510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THL1_RS22515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
THL1_RS22520	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
THL1_RS22530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THL1_RS22545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THL1_RS22555	COG0037	tRNA processing
THL1_RS22560	COG0825	malonyl-CoA metabolic process
THL1_RS22575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THL1_RS22585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THL1_RS22600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THL1_RS22610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THL1_RS22620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THL1_RS22630	COG0528	UMP kinase activity
THL1_RS22640	COG0052	Belongs to the universal ribosomal protein uS2 family
THL1_RS22645	COG0024	Methionine aminopeptidase
THL1_RS22650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THL1_RS22655	COG0436	Aminotransferase
THL1_RS22660	COG1393	Belongs to the ArsC family
THL1_RS22665	COG2171	N-acyltransferase activity
THL1_RS22675	COG2166	iron-sulfur cluster assembly
THL1_RS22680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THL1_RS22685	COG1979	alcohol dehydrogenase
THL1_RS22690	COG1215	transferase activity, transferring glycosyl groups
THL1_RS22700	COG2226	methyltransferase
THL1_RS22730	COG1131	(ABC) transporter
THL1_RS22735	COG2937	Belongs to the GPAT DAPAT family
THL1_RS22760	COG4638	Rieske (2fe-2S)
THL1_RS22770	COG1024	Enoyl-CoA hydratase
THL1_RS22775	COG1022	Amp-dependent synthetase and ligase
THL1_RS22785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS22790	COG1309	transcriptional regulator
THL1_RS22795	COG0742	ribosomal rna small subunit methyltransferase
THL1_RS22805	COG1801	Protein of unknown function DUF72
THL1_RS22815	COG1214	PFAM Peptidase M22, glycoprotease
THL1_RS22820	COG0563	adenylate kinase activity
THL1_RS22825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THL1_RS22835	COG0789	Transcriptional regulator
THL1_RS22855	COG1073	alpha beta
THL1_RS22860	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS22885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THL1_RS22890	COG4251	negative regulation of phosphorylation
THL1_RS22890	COG2203	Gaf domain
THL1_RS22890	COG3706	GGDEF domain
THL1_RS22890	COG5001	Diguanylate cyclase
THL1_RS22905	COG0835	chemotaxis
THL1_RS22940	COG2979	Protein of unknown function (DUF533)
THL1_RS22945	COG0583	DNA-binding transcription factor activity
THL1_RS22955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS22960	COG3842	ATPase activity
THL1_RS22965	COG1176	ABC-type spermidine putrescine transport system, permease component I
THL1_RS22970	COG1177	transmembrane transport
THL1_RS22975	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS22995	COG0628	permease
THL1_RS23000	COG0590	tRNA wobble adenosine to inosine editing
THL1_RS23015	COG3795	YCII-related domain
THL1_RS23020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THL1_RS23035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THL1_RS23050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THL1_RS23065	COG1607	acyl-coa hydrolase
THL1_RS23075	COG0336	Belongs to the RNA methyltransferase TrmD family
THL1_RS23080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THL1_RS23085	COG0228	four-way junction DNA binding
THL1_RS23090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THL1_RS23100	COG4536	flavin adenine dinucleotide binding
THL1_RS23135	COG3034	peptidoglycan biosynthetic process
THL1_RS23165	COG1024	Enoyl-CoA hydratase
THL1_RS23175	COG3706	GGDEF domain
THL1_RS23185	COG3153	acetyltransferase
THL1_RS23185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THL1_RS23205	COG0693	protein deglycase activity
THL1_RS23215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THL1_RS23225	COG1902	pentaerythritol trinitrate reductase activity
THL1_RS23235	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
THL1_RS23280	COG1473	amidohydrolase
THL1_RS23290	COG0154	amidase activity
THL1_RS23315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THL1_RS23325	COG0583	DNA-binding transcription factor activity
THL1_RS23335	COG1279	arginine transmembrane transporter activity
THL1_RS23355	COG1704	LemA family
THL1_RS23385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS23390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THL1_RS23400	COG3642	lipopolysaccharide core region biosynthetic process
THL1_RS23410	COG0642	Histidine kinase
THL1_RS23415	COG0745	RESPONSE REGULATOR receiver
THL1_RS23425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THL1_RS23430	COG3030	protein affecting phage T7 exclusion by the F plasmid
THL1_RS23440	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS23455	COG1595	DNA-templated transcription, initiation
THL1_RS23460	COG3712	iron ion homeostasis
THL1_RS23505	COG0508	dehydrogenase complex catalyzes the overall conversion of
THL1_RS23530	COG2197	response regulator
THL1_RS23550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS23560	COG1028	Short-chain dehydrogenase reductase Sdr
THL1_RS23570	COG0596	Alpha beta hydrolase
THL1_RS23585	COG1366	Belongs to the anti-sigma-factor antagonist family
THL1_RS23590	COG0789	Transcriptional regulator
THL1_RS23610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THL1_RS23630	COG0492	ferredoxin-NADP+ reductase activity
THL1_RS23650	COG1309	transcriptional regulator
THL1_RS23655	COG0386	Belongs to the glutathione peroxidase family
THL1_RS23660	COG1047	Peptidyl-prolyl cis-trans
THL1_RS23675	COG0204	Acyl-transferase
THL1_RS23700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THL1_RS23715	COG2267	carboxylic ester hydrolase activity
THL1_RS23740	COG0318	PFAM AMP-dependent synthetase and ligase
THL1_RS23745	COG0183	Belongs to the thiolase family
THL1_RS23760	COG2365	Tyrosine phosphatase family
THL1_RS23765	COG1280	lysine exporter protein (LysE YggA)
THL1_RS23770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THL1_RS23780	COG0833	amino acid
THL1_RS23785	COG2119	membrane
THL1_RS23800	COG0501	Belongs to the peptidase M48B family
THL1_RS23805	COG0840	transmembrane signaling receptor activity
THL1_RS23810	COG2135	peptidase activity
THL1_RS23860	COG0659	secondary active sulfate transmembrane transporter activity
THL1_RS23870	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THL1_RS23875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THL1_RS23885	COG2271	Major facilitator Superfamily
THL1_RS23895	COG1090	epimerase
THL1_RS23900	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
THL1_RS23930	COG4221	oxidoreductase activity
THL1_RS23945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THL1_RS23960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THL1_RS23965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THL1_RS23975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THL1_RS23995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THL1_RS24015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THL1_RS24050	COG2161	toxin-antitoxin pair type II binding
THL1_RS24060	COG0473	3-isopropylmalate dehydrogenase activity
THL1_RS24070	COG0288	reversible hydration of carbon dioxide
THL1_RS24075	COG0456	acetyltransferase
THL1_RS24085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THL1_RS24125	COG3008	intermembrane lipid transfer
THL1_RS24130	COG2995	paraquat-inducible protein a
THL1_RS24135	COG2995	paraquat-inducible protein a
THL1_RS24165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
THL1_RS24175	COG1183	phosphatidylcholine synthase activity
THL1_RS24185	COG0583	DNA-binding transcription factor activity
THL1_RS24195	COG0028	Belongs to the TPP enzyme family
THL1_RS24205	COG3098	single-species biofilm formation
THL1_RS24215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THL1_RS24245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THL1_RS24250	COG4558	Periplasmic binding protein
THL1_RS24255	COG3720	iron ion transport
THL1_RS24270	COG0436	Aminotransferase
THL1_RS24275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THL1_RS24280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THL1_RS24285	COG4191	Histidine kinase
THL1_RS24305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THL1_RS24310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THL1_RS24335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THL1_RS24335	COG0116	Belongs to the methyltransferase superfamily
THL1_RS24375	COG1185	polyribonucleotide nucleotidyltransferase activity
THL1_RS24380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THL1_RS24385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THL1_RS24390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THL1_RS24400	COG0195	Participates in both transcription termination and antitermination
THL1_RS24405	COG0779	Required for maturation of 30S ribosomal subunits
THL1_RS24420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THL1_RS24430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THL1_RS24435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THL1_RS24445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THL1_RS24495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THL1_RS24500	COG0497	DNA recombination
THL1_RS24510	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THL1_RS24525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THL1_RS24530	COG2186	Transcriptional regulator
THL1_RS24535	COG1620	l-lactate permease
THL1_RS24545	COG0277	FAD linked oxidase domain protein
THL1_RS24555	COG2205	protein histidine kinase activity
THL1_RS24570	COG1280	lysine exporter protein (LysE YggA)
THL1_RS24580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THL1_RS24585	COG3842	ATPase activity
THL1_RS24595	COG1177	transmembrane transport
THL1_RS24615	COG3237	CsbD-like
THL1_RS24670	COG3550	peptidyl-serine autophosphorylation
THL1_RS24690	COG2197	response regulator
THL1_RS24705	COG2204	response regulator
THL1_RS24710	COG4191	Histidine kinase
THL1_RS24795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THL1_RS24830	COG1196	nuclear chromosome segregation
THL1_RS24830	COG0741	lytic transglycosylase activity
THL1_RS24830	COG0739	heme binding
THL1_RS24840	COG1459	type II secretion system
THL1_RS24850	COG2204	response regulator
THL1_RS24855	COG4191	Histidine kinase
THL1_RS24900	COG2824	Alkylphosphonate utilization operon protein PhnA
THL1_RS24920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS24950	COG1309	transcriptional regulator
THL1_RS24960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
THL1_RS24970	COG2197	response regulator
THL1_RS24975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS24975	COG2205	protein histidine kinase activity
THL1_RS24980	COG3397	chitin binding
THL1_RS24985	COG3038	cytochrome b561
THL1_RS25045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THL1_RS25060	COG3447	MASE1 domain protein
THL1_RS25060	COG5001	Diguanylate cyclase
THL1_RS25060	COG5002	protein histidine kinase activity
THL1_RS25065	COG0583	DNA-binding transcription factor activity
THL1_RS25075	COG2814	Major facilitator Superfamily
THL1_RS25085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THL1_RS25090	COG1309	transcriptional regulator
THL1_RS25105	COG2217	Heavy metal translocating P-type atpase
THL1_RS25115	COG0697	spore germination
THL1_RS25130	COG0583	DNA-binding transcription factor activity
THL1_RS25135	COG2910	NAD(P)H-binding
THL1_RS25145	COG2207	Transcriptional regulator
THL1_RS25190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THL1_RS25255	COG3609	addiction module antidote protein, CC2985 family
THL1_RS25260	COG3276	selenocysteine insertion sequence binding
THL1_RS25275	COG2864	formate dehydrogenase
THL1_RS25280	COG0437	4 iron, 4 sulfur cluster binding
THL1_RS25285	COG0243	molybdopterin cofactor binding
THL1_RS25285	COG3383	formate dehydrogenase (NAD+) activity
THL1_RS25290	COG3383	formate dehydrogenase (NAD+) activity
THL1_RS25290	COG0243	molybdopterin cofactor binding
THL1_RS25350	COG4964	Belongs to the GSP D family
THL1_RS25370	COG0840	transmembrane signaling receptor activity
THL1_RS25375	COG4953	penicillin-binding protein 1C
THL1_RS25385	COG2373	Large extracellular alpha-helical protein
THL1_RS25390	COG1283	sodium-dependent phosphate transmembrane transporter activity
THL1_RS25415	COG0534	Mate efflux family protein
THL1_RS25425	COG1166	arginine decarboxylase activity
THL1_RS25430	COG0023	Translation Initiation Factor
THL1_RS25475	COG2264	protein methyltransferase activity
THL1_RS25520	COG2095	MarC family integral membrane protein
THL1_RS25530	COG1802	Transcriptional regulator
THL1_RS25535	COG0683	leucine binding
THL1_RS25550	COG0411	ABC transporter
THL1_RS25560	COG0829	nickel cation binding
THL1_RS25565	COG0831	urea catabolic process
THL1_RS25575	COG0832	Belongs to the urease beta subunit family
THL1_RS25580	COG0804	urea catabolic process
THL1_RS25595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THL1_RS25600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
THL1_RS25605	COG1238	metal cluster binding
THL1_RS25610	COG0443	Heat shock 70 kDa protein
THL1_RS25630	COG1309	transcriptional regulator
THL1_RS25640	COG0830	nickel cation binding
THL1_RS25645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
THL1_RS25655	COG0584	glycerophosphoryl diester phosphodiesterase
THL1_RS25660	COG4221	oxidoreductase activity
THL1_RS25670	COG2423	ornithine cyclodeaminase activity
THL1_RS25700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS25705	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS25710	COG0583	DNA-binding transcription factor activity
THL1_RS25715	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
THL1_RS25740	COG0668	transmembrane transport
THL1_RS25760	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS25780	COG0305	Participates in initiation and elongation during chromosome replication
THL1_RS25785	COG0359	binds to the 23S rRNA
THL1_RS25800	COG0360	Binds together with S18 to 16S ribosomal RNA
THL1_RS25810	COG0557	exoribonuclease II activity
THL1_RS25825	COG0840	transmembrane signaling receptor activity
THL1_RS25830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THL1_RS25835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THL1_RS25845	COG0330	HflC and HflK could
THL1_RS25850	COG0330	HflC and HflK could
THL1_RS25855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THL1_RS25860	COG1923	regulation of RNA biosynthetic process
THL1_RS25865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THL1_RS25875	COG0860	N-Acetylmuramoyl-L-alanine amidase
THL1_RS25880	COG0802	atpase or kinase
THL1_RS25885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THL1_RS25885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THL1_RS25895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
THL1_RS25900	COG1162	GTPase activity
THL1_RS25925	COG0688	phosphatidylethanolamine metabolic process
THL1_RS25935	COG5001	Diguanylate cyclase
THL1_RS25935	COG5002	protein histidine kinase activity
THL1_RS25940	COG0560	Phosphoserine phosphatase
THL1_RS25940	COG3830	Belongs to the UPF0237 family
THL1_RS25960	COG3577	Aspartyl protease
THL1_RS25975	COG3150	esterase
THL1_RS25980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THL1_RS25990	COG0494	nUDIX hydrolase
THL1_RS26005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THL1_RS26010	COG1538	Outer membrane efflux protein
THL1_RS26020	COG1902	pentaerythritol trinitrate reductase activity
THL1_RS26020	COG0446	pyridine nucleotide-disulphide oxidoreductase
THL1_RS26030	COG1519	Transferase
THL1_RS26035	COG0583	DNA-binding transcription factor activity
THL1_RS26050	COG0667	Aldo Keto reductase
THL1_RS26060	COG1960	acyl-CoA dehydrogenase activity
THL1_RS26065	COG1960	acyl-CoA dehydrogenase activity
THL1_RS26075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THL1_RS26075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THL1_RS26090	COG1132	(ABC) transporter
THL1_RS26125	COG1215	transferase activity, transferring glycosyl groups
THL1_RS26135	COG1215	transferase activity, transferring glycosyl groups
THL1_RS26140	COG2192	nodulation
THL1_RS26155	COG3642	lipopolysaccharide core region biosynthetic process
THL1_RS26165	COG0438	transferase activity, transferring glycosyl groups
THL1_RS26170	COG0859	PFAM glycosyl transferase family 9
THL1_RS26175	COG0859	PFAM glycosyl transferase family 9
THL1_RS26205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THL1_RS26215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THL1_RS26220	COG1960	acyl-CoA dehydrogenase activity
THL1_RS26230	COG1196	nuclear chromosome segregation
THL1_RS26230	COG3264	Mechanosensitive ion channel
THL1_RS26235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THL1_RS26240	COG1794	racemase activity, acting on amino acids and derivatives
THL1_RS26245	COG0730	response to heat
THL1_RS26250	COG3118	belongs to the thioredoxin family
THL1_RS26265	COG1192	Involved in chromosome partitioning
THL1_RS26270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THL1_RS26275	COG0493	'glutamate synthase
THL1_RS26280	COG0067	glutamate synthase
THL1_RS26280	COG0069	glutamate synthase activity
THL1_RS26280	COG0070	glutamate synthase
THL1_RS26290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THL1_RS26295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THL1_RS26335	COG0281	malic enzyme
THL1_RS26345	COG1525	nuclease
THL1_RS26350	COG0254	rRNA binding
THL1_RS26355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THL1_RS26360	COG0018	arginyl-trna synthetase
THL1_RS26375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THL1_RS26430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THL1_RS26435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THL1_RS26450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THL1_RS26475	COG0765	amino acid transport
THL1_RS26485	COG1490	D-aminoacyl-tRNA deacylase activity
THL1_RS26500	COG1051	belongs to the nudix hydrolase family
THL1_RS26515	COG2986	histidine ammonia-lyase
THL1_RS26525	COG4176	ABC-type proline glycine betaine transport system permease component
THL1_RS26550	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS26565	COG0402	S-adenosylhomocysteine deaminase activity
THL1_RS26585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THL1_RS26610	COG2354	Protein conserved in bacteria
THL1_RS26615	COG2194	sulfuric ester hydrolase activity
THL1_RS26640	COG4372	Transposase
THL1_RS26645	COG3436	PFAM IS66 Orf2 family protein
THL1_RS26650	COG1217	gtp-binding protein TYPA
THL1_RS26655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THL1_RS26655	COG0301	tRNA thio-modification
THL1_RS26675	COG3852	Histidine kinase
THL1_RS26690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THL1_RS26695	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THL1_RS26705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THL1_RS26710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THL1_RS26715	COG4942	peptidase
THL1_RS26720	COG0793	Belongs to the peptidase S41A family
THL1_RS26725	COG2861	carbohydrate metabolic process
THL1_RS26745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THL1_RS26760	COG0131	Imidazoleglycerol-phosphate dehydratase
THL1_RS26775	COG1194	a g-specific adenine glycosylase
THL1_RS26780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THL1_RS26790	COG0582	viral genome integration into host DNA
THL1_RS26840	COG4215	(ABC) transporter
THL1_RS26860	COG0582	viral genome integration into host DNA
THL1_RS26880	COG1278	Cold shock
THL1_RS26930	COG1484	DNA-dependent DNA replication
THL1_RS26940	COG4372	Transposase
THL1_RS26945	COG3436	PFAM IS66 Orf2 family protein
THL1_RS26950	COG4584	PFAM Integrase catalytic
THL1_RS26955	COG0210	DNA helicase
THL1_RS26970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THL1_RS27025	COG1218	3'(2'),5'-bisphosphate nucleotidase
THL1_RS27030	COG0494	nUDIX hydrolase
THL1_RS27035	COG1011	Hydrolase
THL1_RS27040	COG0583	DNA-binding transcription factor activity
THL1_RS27045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THL1_RS27065	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
THL1_RS27070	COG0824	Thioesterase
THL1_RS27075	COG1454	alcohol dehydrogenase
THL1_RS27080	COG1960	acyl-CoA dehydrogenase activity
THL1_RS27095	COG0778	Nitroreductase
THL1_RS27110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THL1_RS27115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THL1_RS27120	COG0189	ligase activity
THL1_RS27120	COG4067	protein conserved in archaea
THL1_RS27125	COG0189	ligase activity
THL1_RS27145	COG2183	response to ionizing radiation
THL1_RS27180	COG1522	sequence-specific DNA binding
THL1_RS27190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THL1_RS27195	COG0330	HflC and HflK could
THL1_RS27205	COG0484	heat shock protein binding
THL1_RS27215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THL1_RS27215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THL1_RS27230	COG1178	ABC-type Fe3 transport system permease component
THL1_RS27240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THL1_RS27245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THL1_RS27250	COG0006	proline dipeptidase activity
THL1_RS27255	COG3079	Belongs to the UPF0149 family
THL1_RS27275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THL1_RS27295	COG0604	alcohol dehydrogenase
THL1_RS27310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THL1_RS27325	COG0248	Ppx GppA phosphatase
THL1_RS27340	COG0586	Pfam SNARE associated Golgi protein
THL1_RS27350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
THL1_RS27355	COG2050	protein possibly involved in aromatic compounds catabolism
THL1_RS27360	COG1671	Belongs to the UPF0178 family
THL1_RS27365	COG0672	)-iron permease
THL1_RS27390	COG1280	lysine exporter protein (LysE YggA)
THL1_RS27400	COG0488	(ABC) transporter
THL1_RS27420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THL1_RS27445	COG0181	hydroxymethylbilane synthase activity
THL1_RS27455	COG0745	RESPONSE REGULATOR receiver
THL1_RS27455	COG2972	Histidine kinase
THL1_RS27460	COG0165	Argininosuccinate lyase
THL1_RS27480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THL1_RS27485	COG1965	Belongs to the frataxin family
THL1_RS27500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THL1_RS27515	COG1011	Hydrolase
THL1_RS27525	COG0432	Pfam Uncharacterised protein family UPF0047
THL1_RS27530	COG0004	ammonium transporteR
THL1_RS27535	COG0347	Belongs to the P(II) protein family
THL1_RS27605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THL1_RS27610	COG1113	amino acid transport
THL1_RS27635	COG0288	reversible hydration of carbon dioxide
THL1_RS27645	COG4372	Transposase
THL1_RS27680	COG0606	chelatase, subunit chli
THL1_RS27685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
THL1_RS27700	COG3121	Chaperone
THL1_RS27705	COG3188	usher protein
THL1_RS27715	COG0583	DNA-binding transcription factor activity
THL1_RS27745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THL1_RS27760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THL1_RS27765	COG0251	oxidation-reduction process
THL1_RS27770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS27780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS27790	COG1012	belongs to the aldehyde dehydrogenase family
THL1_RS27795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THL1_RS27805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THL1_RS27810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THL1_RS27815	COG0747	negative chemotaxis
THL1_RS27820	COG2003	Belongs to the UPF0758 family
THL1_RS27825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THL1_RS27830	COG0756	dUTP diphosphatase activity
THL1_RS27840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THL1_RS27845	COG0824	Thioesterase
THL1_RS27860	COG0708	Exodeoxyribonuclease III
THL1_RS27870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THL1_RS27875	COG1561	YicC-like family, N-terminal region
THL1_RS27885	COG1758	RNA polymerase activity
THL1_RS27890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THL1_RS27910	COG1917	Cupin 2, conserved barrel domain protein
THL1_RS27910	COG2207	Transcriptional regulator
THL1_RS27925	COG0848	biopolymer transport protein
THL1_RS27935	COG0583	DNA-binding transcription factor activity
THL1_RS27940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THL1_RS27980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THL1_RS28000	COG1253	flavin adenine dinucleotide binding
THL1_RS28010	COG0739	heme binding
THL1_RS28025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THL1_RS28030	COG0573	inorganic phosphate transmembrane transporter activity
THL1_RS28065	COG0577	efflux transmembrane transporter activity
THL1_RS28070	COG0577	efflux transmembrane transporter activity
THL1_RS28070	COG1136	(ABC) transporter
THL1_RS28080	COG0676	glucose-6-phosphate 1-epimerase activity
THL1_RS28130	COG0583	DNA-binding transcription factor activity
THL1_RS28150	COG2808	Putative FMN-binding domain
THL1_RS28175	COG1115	amino acid carrier protein
THL1_RS28180	COG0252	asparaginase activity
THL1_RS28185	COG5016	pyruvate
THL1_RS28185	COG0511	ligase activity, forming carbon-carbon bonds
THL1_RS28190	COG0439	Biotin carboxylase
THL1_RS28195	COG0583	DNA-binding transcription factor activity
THL1_RS28205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THL1_RS28210	COG1126	abc transporter atp-binding protein
THL1_RS28215	COG0765	amino acid transport
THL1_RS28220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THL1_RS28230	COG1737	Transcriptional regulator
THL1_RS28230	COG0837	glucose binding
THL1_RS28235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THL1_RS28240	COG0826	peptidase U32
THL1_RS28245	COG2801	Transposase and inactivated derivatives
THL1_RS28245	COG3415	Transposase
THL1_RS28255	COG0210	DNA helicase
THL1_RS28280	COG2801	Transposase and inactivated derivatives
THL1_RS28280	COG3415	Transposase
THL1_RS28285	COG4651	solute:proton antiporter activity
THL1_RS28285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THL1_RS28295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THL1_RS28300	COG0174	glutamine synthetase
THL1_RS28310	COG1607	acyl-coa hydrolase
THL1_RS28320	COG2847	Copper chaperone PCu(A)C
THL1_RS28345	COG4191	Histidine kinase
THL1_RS28355	COG3547	Transposase (IS116 IS110 IS902 family)
THL1_RS28360	COG0477	Major facilitator Superfamily
THL1_RS28365	COG0523	cobalamin synthesis protein
THL1_RS28390	COG1469	GTP cyclohydrolase I activity
THL1_RS28395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THL1_RS28400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THL1_RS28405	COG1349	DNA-binding transcription factor activity
THL1_RS28410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THL1_RS28435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THL1_RS28440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THL1_RS28450	COG0356	it plays a direct role in the translocation of protons across the membrane
THL1_RS28455	COG3312	ion transport
THL1_RS28460	COG1475	DNA binding
THL1_RS28465	COG1192	Involved in chromosome partitioning
THL1_RS28475	COG0445	tRNA wobble uridine modification
THL1_RS28480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THL1_RS28485	COG0706	membrane insertase activity
THL1_RS28490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THL1_RS28500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THL1_RS28525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP