locus-tag	class	description
PVLB_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PVLB_RS00010	COG0592	DNA-directed DNA polymerase activity
PVLB_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PVLB_RS00020	COG0187	DNA topoisomerase II activity
PVLB_RS00105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PVLB_RS00140	COG2217	Heavy metal translocating P-type atpase
PVLB_RS00180	COG2194	sulfuric ester hydrolase activity
PVLB_RS00230	COG0463	Glycosyl transferase, family 2
PVLB_RS00315	COG0583	DNA-binding transcription factor activity
PVLB_RS00330	COG2843	Capsule synthesis protein
PVLB_RS00370	COG0477	Major facilitator Superfamily
PVLB_RS00380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PVLB_RS00385	COG0751	glycine-tRNA ligase activity
PVLB_RS00390	COG0752	glycyl-tRNA synthetase alpha subunit
PVLB_RS00395	COG2818	Glycosylase
PVLB_RS00410	COG0569	domain protein
PVLB_RS00415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PVLB_RS00420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PVLB_RS00425	COG0242	peptide deformylase activity
PVLB_RS00430	COG0758	DNA mediated transformation
PVLB_RS00435	COG0009	L-threonylcarbamoyladenylate synthase
PVLB_RS00445	COG0408	coproporphyrinogen oxidase activity
PVLB_RS00450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PVLB_RS00460	COG0659	secondary active sulfate transmembrane transporter activity
PVLB_RS00470	COG3119	arylsulfatase activity
PVLB_RS00475	COG0583	DNA-binding transcription factor activity
PVLB_RS00485	COG0159	tryptophan synthase activity
PVLB_RS00490	COG0133	tryptophan synthase activity
PVLB_RS00505	COG3360	Dodecin
PVLB_RS00515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PVLB_RS00520	COG1764	response to oxidative stress
PVLB_RS00550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PVLB_RS00555	COG0339	signal peptide processing
PVLB_RS00560	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PVLB_RS00580	COG0659	secondary active sulfate transmembrane transporter activity
PVLB_RS00590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PVLB_RS00595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PVLB_RS00600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PVLB_RS00625	COG1612	heme a metabolic process
PVLB_RS00630	COG0109	protoheme IX farnesyltransferase activity
PVLB_RS00645	COG2011	ABC-type metal ion transport system permease component
PVLB_RS00650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PVLB_RS00665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PVLB_RS00670	COG1121	(ABC) transporter
PVLB_RS00675	COG0735	belongs to the Fur family
PVLB_RS00680	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PVLB_RS00700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PVLB_RS00705	COG3245	cytochrome
PVLB_RS00715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PVLB_RS00735	COG3023	N-Acetylmuramoyl-L-alanine amidase
PVLB_RS00740	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PVLB_RS00745	COG5002	protein histidine kinase activity
PVLB_RS00750	COG2204	response regulator
PVLB_RS00775	COG1301	dicarboxylic acid transport
PVLB_RS00780	COG0700	Nucleoside recognition
PVLB_RS00795	COG1127	ABC transporter
PVLB_RS00800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PVLB_RS00815	COG1283	sodium-dependent phosphate transmembrane transporter activity
PVLB_RS00820	COG0861	Integral membrane protein TerC family
PVLB_RS00825	COG2851	Citrate transporter
PVLB_RS00860	COG0427	acetyl-CoA hydrolase
PVLB_RS00880	COG0583	DNA-binding transcription factor activity
PVLB_RS00885	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS00950	COG1802	Transcriptional regulator
PVLB_RS00960	COG2199	diguanylate cyclase activity
PVLB_RS00960	COG2200	EAL domain
PVLB_RS00960	COG3287	FIST C domain
PVLB_RS01010	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS01015	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS01020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PVLB_RS01025	COG3118	belongs to the thioredoxin family
PVLB_RS01025	COG0457	Tetratricopeptide repeat
PVLB_RS01030	COG2175	clavaminate synthase activity
PVLB_RS01045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PVLB_RS01065	COG1335	isochorismatase
PVLB_RS01070	COG4191	Histidine kinase
PVLB_RS01075	COG4566	intracellular signal transduction
PVLB_RS01080	COG4566	intracellular signal transduction
PVLB_RS01090	COG0606	chelatase, subunit chli
PVLB_RS01110	COG0347	Belongs to the P(II) protein family
PVLB_RS01115	COG0004	ammonium transporteR
PVLB_RS01125	COG0546	phosphoglycolate phosphatase activity
PVLB_RS01130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PVLB_RS01140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PVLB_RS01145	COG0019	diaminopimelate decarboxylase activity
PVLB_RS01155	COG1965	Belongs to the frataxin family
PVLB_RS01165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PVLB_RS01170	COG3072	Adenylate cyclase
PVLB_RS01185	COG0625	glutathione transferase activity
PVLB_RS01190	COG0165	Argininosuccinate lyase
PVLB_RS01200	COG0181	hydroxymethylbilane synthase activity
PVLB_RS01220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PVLB_RS01245	COG0488	(ABC) transporter
PVLB_RS01255	COG1280	lysine exporter protein (LysE YggA)
PVLB_RS01285	COG0517	IMP dehydrogenase activity
PVLB_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS01300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PVLB_RS01310	COG2199	diguanylate cyclase activity
PVLB_RS01325	COG2011	ABC-type metal ion transport system permease component
PVLB_RS01330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PVLB_RS01355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PVLB_RS01360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PVLB_RS01375	COG0494	nUDIX hydrolase
PVLB_RS01380	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PVLB_RS01390	COG0730	response to heat
PVLB_RS01395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PVLB_RS01400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PVLB_RS01405	COG0789	Transcriptional regulator
PVLB_RS01415	COG0583	DNA-binding transcription factor activity
PVLB_RS01420	COG3842	ATPase activity
PVLB_RS01425	COG1178	ABC-type Fe3 transport system permease component
PVLB_RS01430	COG1840	ABC-type Fe3 transport system, periplasmic component
PVLB_RS01440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PVLB_RS01455	COG1823	symporter activity
PVLB_RS01465	COG0129	dihydroxy-acid dehydratase activity
PVLB_RS01470	COG2239	Acts as a magnesium transporter
PVLB_RS01475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PVLB_RS01485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PVLB_RS01490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PVLB_RS01495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PVLB_RS01515	COG1309	transcriptional regulator
PVLB_RS01535	COG0612	Peptidase, M16
PVLB_RS01540	COG0742	ribosomal rna small subunit methyltransferase
PVLB_RS01545	COG0612	Peptidase, M16
PVLB_RS01550	COG0612	Peptidase, M16
PVLB_RS01555	COG0552	protein localization to endoplasmic reticulum
PVLB_RS01560	COG2884	Cell division ATP-binding protein ftsE
PVLB_RS01565	COG2177	Part of the ABC transporter FtsEX involved in
PVLB_RS01575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PVLB_RS01580	COG2363	Small membrane protein
PVLB_RS01585	COG2104	thiamine diphosphate biosynthetic process
PVLB_RS01585	COG2022	thiamine diphosphate biosynthetic process
PVLB_RS01590	COG2022	thiamine diphosphate biosynthetic process
PVLB_RS01595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PVLB_RS01605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PVLB_RS01610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PVLB_RS01620	COG2813	Specifically methylates the guanine in position
PVLB_RS01620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PVLB_RS01625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PVLB_RS01650	COG0791	NLP P60 protein
PVLB_RS01665	COG0018	arginyl-trna synthetase
PVLB_RS01670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PVLB_RS01675	COG0254	rRNA binding
PVLB_RS01685	COG0281	malic enzyme
PVLB_RS01715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PVLB_RS01720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PVLB_RS01730	COG0070	glutamate synthase
PVLB_RS01730	COG0069	glutamate synthase activity
PVLB_RS01730	COG0067	glutamate synthase
PVLB_RS01735	COG0493	'glutamate synthase
PVLB_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PVLB_RS01760	COG2814	Major facilitator Superfamily
PVLB_RS01765	COG0583	DNA-binding transcription factor activity
PVLB_RS01770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PVLB_RS01775	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS01825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PVLB_RS01835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PVLB_RS01855	COG1192	Involved in chromosome partitioning
PVLB_RS01860	COG3118	belongs to the thioredoxin family
PVLB_RS01865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PVLB_RS01870	COG1196	nuclear chromosome segregation
PVLB_RS01870	COG3264	Mechanosensitive ion channel
PVLB_RS01875	COG3263	regulation of cellular component size
PVLB_RS01880	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PVLB_RS01885	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS01890	COG1309	transcriptional regulator
PVLB_RS01895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PVLB_RS01905	COG2861	carbohydrate metabolic process
PVLB_RS01910	COG0793	Belongs to the peptidase S41A family
PVLB_RS01915	COG4942	peptidase
PVLB_RS01925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PVLB_RS01945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PVLB_RS01965	COG3852	Histidine kinase
PVLB_RS01980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PVLB_RS01980	COG0301	tRNA thio-modification
PVLB_RS01985	COG1217	gtp-binding protein TYPA
PVLB_RS01995	COG0058	SHG alpha-glucan phosphorylase activity
PVLB_RS02000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PVLB_RS02025	COG0402	S-adenosylhomocysteine deaminase activity
PVLB_RS02030	COG2188	Transcriptional regulator
PVLB_RS02040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PVLB_RS02050	COG4176	ABC-type proline glycine betaine transport system permease component
PVLB_RS02055	COG4175	Glycine betaine
PVLB_RS02055	COG0517	IMP dehydrogenase activity
PVLB_RS02060	COG2986	histidine ammonia-lyase
PVLB_RS02065	COG2986	histidine ammonia-lyase
PVLB_RS02070	COG1228	amidohydrolase
PVLB_RS02090	COG1490	D-aminoacyl-tRNA deacylase activity
PVLB_RS02095	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PVLB_RS02100	COG2943	transferase activity, transferring hexosyl groups
PVLB_RS02110	COG0765	amino acid transport
PVLB_RS02115	COG1126	abc transporter atp-binding protein
PVLB_RS02120	COG0840	transmembrane signaling receptor activity
PVLB_RS02125	COG0840	transmembrane signaling receptor activity
PVLB_RS02140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PVLB_RS02145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PVLB_RS02150	COG0140	phosphoribosyl-ATP diphosphatase activity
PVLB_RS02155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PVLB_RS02160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PVLB_RS02170	COG2226	methyltransferase
PVLB_RS02215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PVLB_RS02220	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PVLB_RS02225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PVLB_RS02230	COG0540	Belongs to the ATCase OTCase family
PVLB_RS02235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PVLB_RS02240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PVLB_RS02245	COG1678	Uncharacterized ACR, COG1678
PVLB_RS02255	COG0189	ligase activity
PVLB_RS02280	COG2198	Histidine kinase
PVLB_RS02280	COG0784	Response regulator, receiver
PVLB_RS02280	COG0643	Histidine kinase
PVLB_RS02290	COG1272	protein, Hemolysin III
PVLB_RS02295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PVLB_RS02310	COG3038	cytochrome b561
PVLB_RS02315	COG2353	YceI-like domain
PVLB_RS02320	COG0513	Belongs to the DEAD box helicase family
PVLB_RS02335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PVLB_RS02340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PVLB_RS02380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PVLB_RS02385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PVLB_RS02390	COG4106	trans-aconitate 2-methyltransferase activity
PVLB_RS02395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PVLB_RS02400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PVLB_RS02405	COG0126	phosphoglycerate kinase activity
PVLB_RS02430	COG1451	nucleotide metabolic process
PVLB_RS02445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PVLB_RS02460	COG1289	transmembrane transporter activity
PVLB_RS02465	COG2081	HI0933 family
PVLB_RS02470	COG0513	Belongs to the DEAD box helicase family
PVLB_RS02475	COG0477	Major facilitator Superfamily
PVLB_RS02505	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS02510	COG0506	proline dehydrogenase activity
PVLB_RS02510	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PVLB_RS02510	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PVLB_RS02515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PVLB_RS02520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PVLB_RS02525	COG2192	nodulation
PVLB_RS02530	COG0438	transferase activity, transferring glycosyl groups
PVLB_RS02555	COG0438	transferase activity, transferring glycosyl groups
PVLB_RS02570	COG1132	(ABC) transporter
PVLB_RS02575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PVLB_RS02575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PVLB_RS02585	COG0667	Aldo Keto reductase
PVLB_RS02605	COG1519	Transferase
PVLB_RS02610	COG1538	Outer membrane efflux protein
PVLB_RS02615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PVLB_RS02630	COG0494	nUDIX hydrolase
PVLB_RS02640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PVLB_RS02645	COG3150	esterase
PVLB_RS02660	COG3577	Aspartyl protease
PVLB_RS02680	COG0560	Phosphoserine phosphatase
PVLB_RS02680	COG3830	Belongs to the UPF0237 family
PVLB_RS02690	COG0688	phosphatidylethanolamine metabolic process
PVLB_RS02705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PVLB_RS02715	COG1162	GTPase activity
PVLB_RS02720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PVLB_RS02725	COG2860	membrane
PVLB_RS02735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PVLB_RS02735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PVLB_RS02740	COG0802	atpase or kinase
PVLB_RS02745	COG0860	N-Acetylmuramoyl-L-alanine amidase
PVLB_RS02750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PVLB_RS02755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PVLB_RS02760	COG1923	regulation of RNA biosynthetic process
PVLB_RS02765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PVLB_RS02770	COG0330	HflC and HflK could
PVLB_RS02775	COG0330	HflC and HflK could
PVLB_RS02780	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PVLB_RS02785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PVLB_RS02790	COG0840	transmembrane signaling receptor activity
PVLB_RS02795	COG2197	response regulator
PVLB_RS02800	COG3916	Acyl-homoserine-lactone synthase
PVLB_RS02805	COG2249	NAD(P)H dehydrogenase (quinone) activity
PVLB_RS02820	COG0446	pyridine nucleotide-disulphide oxidoreductase
PVLB_RS02820	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS02840	COG1178	ABC-type Fe3 transport system permease component
PVLB_RS02845	COG1840	ABC-type Fe3 transport system, periplasmic component
PVLB_RS02860	COG0557	exoribonuclease II activity
PVLB_RS02865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PVLB_RS02870	COG0360	Binds together with S18 to 16S ribosomal RNA
PVLB_RS02875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PVLB_RS02885	COG0359	binds to the 23S rRNA
PVLB_RS02890	COG0305	Participates in initiation and elongation during chromosome replication
PVLB_RS02895	COG5265	(ABC) transporter
PVLB_RS02910	COG1032	radical SAM domain protein
PVLB_RS02925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PVLB_RS02930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PVLB_RS02960	COG4221	oxidoreductase activity
PVLB_RS02980	COG2982	Protein involved in outer membrane biogenesis
PVLB_RS02995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PVLB_RS03010	COG0443	Heat shock 70 kDa protein
PVLB_RS03020	COG0789	Transcriptional regulator
PVLB_RS03035	COG0411	ABC transporter
PVLB_RS03055	COG1113	amino acid transport
PVLB_RS03090	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PVLB_RS03100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PVLB_RS03130	COG2095	MarC family integral membrane protein
PVLB_RS03140	COG0151	Belongs to the GarS family
PVLB_RS03145	COG0138	bifunctional purine biosynthesis protein purh
PVLB_RS03155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PVLB_RS03165	COG2264	protein methyltransferase activity
PVLB_RS03170	COG2951	lytic endotransglycosylase activity
PVLB_RS03190	COG0495	leucyl-tRNA aminoacylation
PVLB_RS03205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PVLB_RS03210	COG4535	Mg2 and Co2 transporter CorC
PVLB_RS03215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PVLB_RS03220	COG1702	phosphate starvation-inducible protein PhoH
PVLB_RS03235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PVLB_RS03240	COG0352	thiamine-phosphate diphosphorylase activity
PVLB_RS03245	COG0351	phosphomethylpyrimidine kinase
PVLB_RS03250	COG2205	protein histidine kinase activity
PVLB_RS03250	COG3437	response regulator, receiver
PVLB_RS03250	COG4999	Histidine kinase
PVLB_RS03250	COG3850	Histidine kinase
PVLB_RS03255	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS03260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PVLB_RS03275	COG1522	sequence-specific DNA binding
PVLB_RS03295	COG1643	Atp-dependent helicase
PVLB_RS03305	COG3416	Protein conserved in bacteria
PVLB_RS03315	COG1522	sequence-specific DNA binding
PVLB_RS03320	COG0697	spore germination
PVLB_RS03325	COG0513	Belongs to the DEAD box helicase family
PVLB_RS03335	COG0123	including yeast histone deacetylase and acetoin utilization protein
PVLB_RS03350	COG1946	Acyl-CoA thioesterase
PVLB_RS03355	COG0546	phosphoglycolate phosphatase activity
PVLB_RS03360	COG1064	alcohol dehydrogenase
PVLB_RS03440	COG1304	FMN binding
PVLB_RS03445	COG1620	l-lactate permease
PVLB_RS03450	COG2186	Transcriptional regulator
PVLB_RS03455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PVLB_RS03465	COG2914	Belongs to the UPF0125 (RnfH) family
PVLB_RS03470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PVLB_RS03475	COG0735	belongs to the Fur family
PVLB_RS03480	COG0497	DNA recombination
PVLB_RS03485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PVLB_RS03490	COG0443	Heat shock 70 kDa protein
PVLB_RS03495	COG0484	heat shock protein binding
PVLB_RS03500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PVLB_RS03505	COG0505	Belongs to the CarA family
PVLB_RS03510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PVLB_RS03515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PVLB_RS03530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PVLB_RS03540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PVLB_RS03545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PVLB_RS03550	COG0149	triose-phosphate isomerase activity
PVLB_RS03555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PVLB_RS03570	COG0779	Required for maturation of 30S ribosomal subunits
PVLB_RS03575	COG0195	Participates in both transcription termination and antitermination
PVLB_RS03580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PVLB_RS03585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PVLB_RS03590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PVLB_RS03595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PVLB_RS03600	COG1185	polyribonucleotide nucleotidyltransferase activity
PVLB_RS03605	COG2823	Periplasmic or secreted lipoprotein
PVLB_RS03630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PVLB_RS03635	COG0166	Belongs to the GPI family
PVLB_RS03640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PVLB_RS03645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PVLB_RS03655	COG0617	tRNA 3'-terminal CCA addition
PVLB_RS03660	COG2204	response regulator
PVLB_RS03665	COG4191	Histidine kinase
PVLB_RS03675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PVLB_RS03685	COG0436	Aminotransferase
PVLB_RS03690	COG1489	DNA binding
PVLB_RS03700	COG4558	Periplasmic binding protein
PVLB_RS03705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PVLB_RS03710	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PVLB_RS03735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PVLB_RS03745	COG3098	single-species biofilm formation
PVLB_RS03750	COG0028	Belongs to the TPP enzyme family
PVLB_RS03760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PVLB_RS03765	COG1183	phosphatidylcholine synthase activity
PVLB_RS03770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PVLB_RS03775	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PVLB_RS03805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PVLB_RS03810	COG1074	ATP-dependent DNA helicase activity
PVLB_RS03815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PVLB_RS03825	COG2199	diguanylate cyclase activity
PVLB_RS03855	COG4589	Belongs to the CDS family
PVLB_RS03870	COG0671	phosphoesterase, PA-phosphatase related
PVLB_RS03870	COG2453	phosphatase
PVLB_RS03875	COG2267	carboxylic ester hydrolase activity
PVLB_RS03880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PVLB_RS03885	COG0583	DNA-binding transcription factor activity
PVLB_RS03900	COG2249	NAD(P)H dehydrogenase (quinone) activity
PVLB_RS03905	COG0583	DNA-binding transcription factor activity
PVLB_RS03915	COG0840	transmembrane signaling receptor activity
PVLB_RS03920	COG2321	neutral zinc metallopeptidase
PVLB_RS03925	COG3485	protocatechuate 3,4-dioxygenase
PVLB_RS03930	COG3485	protocatechuate 3,4-dioxygenase
PVLB_RS03935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PVLB_RS03940	COG2252	PERMEase
PVLB_RS03950	COG1271	oxidase subunit
PVLB_RS03955	COG1294	oxidase, subunit
PVLB_RS03965	COG2813	Specifically methylates the guanine in position
PVLB_RS03970	COG2197	response regulator
PVLB_RS03980	COG1970	mechanosensitive ion channel activity
PVLB_RS03990	COG2233	PERMEase
PVLB_RS04000	COG1966	Carbon starvation protein
PVLB_RS04005	COG2879	small protein
PVLB_RS04010	COG0523	cobalamin synthesis protein
PVLB_RS04020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PVLB_RS04030	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PVLB_RS04070	COG1366	Belongs to the anti-sigma-factor antagonist family
PVLB_RS04080	COG0583	DNA-binding transcription factor activity
PVLB_RS04085	COG1380	Effector of murein hydrolase LrgA
PVLB_RS04090	COG1346	cytolysis
PVLB_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS04110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PVLB_RS04175	COG2207	Transcriptional regulator
PVLB_RS04175	COG3708	Transcriptional regulator
PVLB_RS04180	COG0697	spore germination
PVLB_RS04185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PVLB_RS04190	COG0583	DNA-binding transcription factor activity
PVLB_RS04210	COG1566	PFAM secretion protein HlyD family protein
PVLB_RS04240	COG0300	oxidoreductase activity
PVLB_RS04255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PVLB_RS04255	COG0662	Cupin 2, conserved barrel domain protein
PVLB_RS04270	COG1696	Membrane protein involved in D-alanine export
PVLB_RS04285	COG3420	alginic acid biosynthetic process
PVLB_RS04295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PVLB_RS04300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS04305	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS04310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PVLB_RS04325	COG1136	(ABC) transporter
PVLB_RS04330	COG1136	(ABC) transporter
PVLB_RS04330	COG0577	efflux transmembrane transporter activity
PVLB_RS04345	COG3022	response to hydroperoxide
PVLB_RS04355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PVLB_RS04360	COG0315	cyclic pyranopterin monophosphate synthase activity
PVLB_RS04365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PVLB_RS04375	COG0513	Belongs to the DEAD box helicase family
PVLB_RS04380	COG0400	carboxylic ester hydrolase activity
PVLB_RS04385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS04390	COG4597	amino acid ABC transporter
PVLB_RS04395	COG0765	amino acid transport
PVLB_RS04400	COG1126	abc transporter atp-binding protein
PVLB_RS04405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PVLB_RS04415	COG0175	sulfate reduction
PVLB_RS04425	COG1522	sequence-specific DNA binding
PVLB_RS04450	COG0180	Tryptophanyl-tRNA synthetase
PVLB_RS04455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PVLB_RS04465	COG0667	Aldo Keto reductase
PVLB_RS04470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PVLB_RS04475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PVLB_RS04480	COG0723	plastoquinol--plastocyanin reductase activity
PVLB_RS04485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PVLB_RS04490	COG2857	Cytochrome c1
PVLB_RS04495	COG0625	glutathione transferase activity
PVLB_RS04500	COG2969	positive regulation of protein catabolic process
PVLB_RS04510	COG2823	Periplasmic or secreted lipoprotein
PVLB_RS04515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PVLB_RS04520	COG0792	nuclease activity
PVLB_RS04525	COG3107	peptidoglycan biosynthetic process
PVLB_RS04535	COG2001	Belongs to the MraZ family
PVLB_RS04540	COG0275	rRNA processing
PVLB_RS04555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PVLB_RS04560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PVLB_RS04565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PVLB_RS04570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PVLB_RS04575	COG0772	Belongs to the SEDS family
PVLB_RS04580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PVLB_RS04585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PVLB_RS04590	COG1181	Belongs to the D-alanine--D-alanine ligase family
PVLB_RS04605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PVLB_RS04610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PVLB_RS04620	COG0653	protein targeting
PVLB_RS04625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PVLB_RS04635	COG0494	nUDIX hydrolase
PVLB_RS04640	COG2096	Adenosyltransferase
PVLB_RS04645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS04645	COG4191	Histidine kinase
PVLB_RS04655	COG1666	GTP binding
PVLB_RS04660	COG0668	transmembrane transport
PVLB_RS04690	COG3030	protein affecting phage T7 exclusion by the F plasmid
PVLB_RS04695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PVLB_RS04700	COG0459	protein refolding
PVLB_RS04715	COG0642	Histidine kinase
PVLB_RS04725	COG3642	lipopolysaccharide core region biosynthetic process
PVLB_RS04750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PVLB_RS04755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS04785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PVLB_RS04795	COG0583	DNA-binding transcription factor activity
PVLB_RS04800	COG0702	epimerase
PVLB_RS04810	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS04860	COG0693	protein deglycase activity
PVLB_RS04875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PVLB_RS04875	COG3153	acetyltransferase
PVLB_RS04905	COG2925	Exonuclease
PVLB_RS04915	COG0788	formyltetrahydrofolate deformylase activity
PVLB_RS04935	COG0840	transmembrane signaling receptor activity
PVLB_RS04940	COG0433	COG0433 Predicted ATPase
PVLB_RS04945	COG0306	phosphate transporter
PVLB_RS04955	COG1414	Transcriptional regulator
PVLB_RS04960	COG2814	Major facilitator Superfamily
PVLB_RS04965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PVLB_RS04970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PVLB_RS04975	COG0183	Belongs to the thiolase family
PVLB_RS04980	COG0477	Major facilitator Superfamily
PVLB_RS04985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PVLB_RS04990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PVLB_RS04995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PVLB_RS05025	COG1309	transcriptional regulator
PVLB_RS05030	COG0477	Major facilitator Superfamily
PVLB_RS05035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PVLB_RS05045	COG2910	NAD(P)H-binding
PVLB_RS05050	COG0583	DNA-binding transcription factor activity
PVLB_RS05060	COG2207	Transcriptional regulator
PVLB_RS05090	COG0477	Major facilitator Superfamily
PVLB_RS05100	COG4191	Histidine kinase
PVLB_RS05160	COG1024	Enoyl-CoA hydratase
PVLB_RS05165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PVLB_RS05170	COG3180	Ammonia monooxygenase
PVLB_RS05210	COG0354	folic acid binding
PVLB_RS05215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PVLB_RS05245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PVLB_RS05250	COG0481	GTPase activity
PVLB_RS05255	COG0681	Belongs to the peptidase S26 family
PVLB_RS05260	COG0571	ribonuclease III activity
PVLB_RS05265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PVLB_RS05270	COG1381	Involved in DNA repair and RecF pathway recombination
PVLB_RS05275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PVLB_RS05295	COG0500	methyltransferase
PVLB_RS05300	COG2226	methyltransferase
PVLB_RS05310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PVLB_RS05325	COG4206	TonB-dependent receptor
PVLB_RS05330	COG4628	conserved protein (DUF2132)
PVLB_RS05340	COG2375	cellular response to nickel ion
PVLB_RS05345	COG1695	Transcriptional regulator
PVLB_RS05355	COG1113	amino acid transport
PVLB_RS05375	COG1201	RNA secondary structure unwinding
PVLB_RS05380	COG0494	nUDIX hydrolase
PVLB_RS05385	COG0583	DNA-binding transcription factor activity
PVLB_RS05410	COG1126	abc transporter atp-binding protein
PVLB_RS05415	COG0765	amino acid transport
PVLB_RS05420	COG0765	amino acid transport
PVLB_RS05425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS05445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PVLB_RS05455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PVLB_RS05460	COG3842	ATPase activity
PVLB_RS05465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PVLB_RS05470	COG0243	molybdopterin cofactor binding
PVLB_RS05475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PVLB_RS05485	COG0450	alkyl hydroperoxide reductase
PVLB_RS05490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PVLB_RS05495	COG0418	dihydroorotase activity
PVLB_RS05505	COG0137	argininosuccinate synthase activity
PVLB_RS05515	COG2197	response regulator
PVLB_RS05525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PVLB_RS05535	COG4659	FMN binding
PVLB_RS05545	COG2878	Part of a membrane complex involved in electron transport
PVLB_RS05550	COG4657	Part of a membrane complex involved in electron transport
PVLB_RS05555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PVLB_RS05555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PVLB_RS05560	COG0489	protein tyrosine kinase activity
PVLB_RS05565	COG1278	Cold shock
PVLB_RS05570	COG0717	Belongs to the dCTP deaminase family
PVLB_RS05585	COG2366	antibiotic biosynthetic process
PVLB_RS05600	COG3012	SEC-C Motif Domain Protein
PVLB_RS05675	COG1199	ATP-dependent helicase activity
PVLB_RS05695	COG0259	pyridoxamine-phosphate oxidase activity
PVLB_RS05710	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PVLB_RS05760	COG2084	Dehydrogenase
PVLB_RS05770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PVLB_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS05810	COG0583	DNA-binding transcription factor activity
PVLB_RS05820	COG5001	Diguanylate cyclase
PVLB_RS05830	COG2116	formate transmembrane transporter activity
PVLB_RS05865	COG3318	Belongs to the UPF0149 family
PVLB_RS05865	COG3012	SEC-C Motif Domain Protein
PVLB_RS05870	COG0625	glutathione transferase activity
PVLB_RS05875	COG1017	nitric oxide dioxygenase activity
PVLB_RS05875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PVLB_RS05915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PVLB_RS05925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PVLB_RS05935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PVLB_RS05935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PVLB_RS05945	COG2205	protein histidine kinase activity
PVLB_RS05990	COG1301	dicarboxylic acid transport
PVLB_RS06000	COG3091	SprT-like family
PVLB_RS06010	COG0037	tRNA processing
PVLB_RS06030	COG1393	Belongs to the ArsC family
PVLB_RS06050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PVLB_RS06055	COG2205	protein histidine kinase activity
PVLB_RS06055	COG5002	protein histidine kinase activity
PVLB_RS06055	COG0784	Response regulator, receiver
PVLB_RS06075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PVLB_RS06080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PVLB_RS06085	COG3956	TIGRFAM MazG family protein
PVLB_RS06090	COG3122	Protein conserved in bacteria
PVLB_RS06105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PVLB_RS06110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PVLB_RS06120	COG0628	permease
PVLB_RS06130	COG0791	NLP P60 protein
PVLB_RS06135	COG0791	NLP P60 protein
PVLB_RS06145	COG1797	cobyrinic acid a,c-diamide synthase activity
PVLB_RS06150	COG0778	Nitroreductase
PVLB_RS06155	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PVLB_RS06165	COG1492	cobalamin metabolic process
PVLB_RS06175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PVLB_RS06180	COG0406	alpha-ribazole phosphatase activity
PVLB_RS06185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PVLB_RS06190	COG1846	Transcriptional regulator
PVLB_RS06240	COG2205	protein histidine kinase activity
PVLB_RS06245	COG2814	Major facilitator Superfamily
PVLB_RS06250	COG2188	Transcriptional regulator
PVLB_RS06255	COG2814	Major facilitator Superfamily
PVLB_RS06260	COG3618	amidohydrolase
PVLB_RS06265	COG0840	transmembrane signaling receptor activity
PVLB_RS06275	COG2076	Multidrug Resistance protein
PVLB_RS06280	COG0385	Bile acid
PVLB_RS06285	COG2974	May be involved in recombination
PVLB_RS06300	COG0024	Methionine aminopeptidase
PVLB_RS06305	COG0243	molybdopterin cofactor binding
PVLB_RS06310	COG2146	nitrite reductase [NAD(P)H] activity
PVLB_RS06310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PVLB_RS06315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PVLB_RS06315	COG2146	nitrite reductase [NAD(P)H] activity
PVLB_RS06320	COG0583	DNA-binding transcription factor activity
PVLB_RS06330	COG3339	Conserved Protein
PVLB_RS06345	COG2200	EAL domain
PVLB_RS06365	COG0793	Belongs to the peptidase S41A family
PVLB_RS06390	COG0395	ABC-type sugar transport system, permease component
PVLB_RS06395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PVLB_RS06410	COG0668	transmembrane transport
PVLB_RS06415	COG1362	aminopeptidase activity
PVLB_RS06420	COG0564	pseudouridine synthase activity
PVLB_RS06425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PVLB_RS06430	COG2894	cell division
PVLB_RS06435	COG0850	regulation of cytokinetic process
PVLB_RS06440	COG1560	Kdo2-lipid A biosynthetic process
PVLB_RS06450	COG2853	Lipoprotein
PVLB_RS06470	COG2113	Glycine betaine
PVLB_RS06475	COG3162	membrane
PVLB_RS06480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PVLB_RS06500	COG3089	Belongs to the UPF0270 family
PVLB_RS06505	COG1363	Peptidase, m42
PVLB_RS06510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PVLB_RS06510	COG0189	ligase activity
PVLB_RS06515	COG0367	asparagine synthase
PVLB_RS06520	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PVLB_RS06520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS06525	COG2326	polyphosphate kinase activity
PVLB_RS06530	COG0697	spore germination
PVLB_RS06535	COG0114	fumarate hydratase activity
PVLB_RS06545	COG0271	Belongs to the BolA IbaG family
PVLB_RS06550	COG1054	Belongs to the UPF0176 family
PVLB_RS06565	COG5002	protein histidine kinase activity
PVLB_RS06565	COG5001	Diguanylate cyclase
PVLB_RS06575	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS06580	COG0546	phosphoglycolate phosphatase activity
PVLB_RS06585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PVLB_RS06590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PVLB_RS06600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PVLB_RS06610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PVLB_RS06615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PVLB_RS06630	COG0776	regulation of translation
PVLB_RS06640	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PVLB_RS06655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PVLB_RS06690	COG0367	asparagine synthase
PVLB_RS06695	COG0438	transferase activity, transferring glycosyl groups
PVLB_RS06700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PVLB_RS06750	COG1555	photosystem II stabilization
PVLB_RS06755	COG0284	orotidine-5'-phosphate decarboxylase activity
PVLB_RS06765	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS06780	COG2130	NADP-dependent
PVLB_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS06795	COG0436	Aminotransferase
PVLB_RS06805	COG3135	benzoate transporter
PVLB_RS06810	COG0625	glutathione transferase activity
PVLB_RS06820	COG0302	gtp cyclohydrolase
PVLB_RS06855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PVLB_RS06860	COG2814	Major facilitator Superfamily
PVLB_RS06865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PVLB_RS06890	COG1368	sulfuric ester hydrolase activity
PVLB_RS06910	COG0519	Catalyzes the synthesis of GMP from XMP
PVLB_RS06915	COG0598	Magnesium transport protein CorA
PVLB_RS06920	COG0204	Acyl-transferase
PVLB_RS06940	COG2814	Major facilitator Superfamily
PVLB_RS06945	COG0583	DNA-binding transcription factor activity
PVLB_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS06955	COG0583	DNA-binding transcription factor activity
PVLB_RS06975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PVLB_RS06980	COG1764	response to oxidative stress
PVLB_RS06985	COG1846	Transcriptional regulator
PVLB_RS06990	COG0583	DNA-binding transcription factor activity
PVLB_RS07000	COG0583	DNA-binding transcription factor activity
PVLB_RS07010	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PVLB_RS07025	COG3384	dioxygenase
PVLB_RS07030	COG0500	methyltransferase
PVLB_RS07035	COG0501	Belongs to the peptidase M48B family
PVLB_RS07040	COG0436	Aminotransferase
PVLB_RS07045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PVLB_RS07050	COG0386	Belongs to the glutathione peroxidase family
PVLB_RS07065	COG1956	GAF domain-containing protein
PVLB_RS07105	COG3188	usher protein
PVLB_RS07125	COG3468	outer membrane autotransporter barrel domain protein
PVLB_RS07155	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS07160	COG0625	glutathione transferase activity
PVLB_RS07165	COG1131	(ABC) transporter
PVLB_RS07170	COG0842	Transport permease protein
PVLB_RS07185	COG0811	peptide transport
PVLB_RS07190	COG0848	biopolymer transport protein
PVLB_RS07195	COG1663	tetraacyldisaccharide 4'-kinase activity
PVLB_RS07200	COG2835	tetraacyldisaccharide 4'-kinase activity
PVLB_RS07205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PVLB_RS07210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PVLB_RS07215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PVLB_RS07220	COG1530	ribonuclease E activity
PVLB_RS07230	COG0546	phosphoglycolate phosphatase activity
PVLB_RS07235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PVLB_RS07235	COG0616	signal peptide processing
PVLB_RS07240	COG0424	maF-like protein
PVLB_RS07250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PVLB_RS07255	COG0416	fatty acid biosynthetic process
PVLB_RS07260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PVLB_RS07270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PVLB_RS07275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PVLB_RS07285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PVLB_RS07300	COG0084	hydrolase, TatD family'
PVLB_RS07315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PVLB_RS07345	COG0556	nucleotide-excision repair
PVLB_RS07360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PVLB_RS07410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PVLB_RS07430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PVLB_RS07435	COG0066	3-isopropylmalate dehydratase activity
PVLB_RS07440	COG2226	methyltransferase
PVLB_RS07445	COG0473	3-isopropylmalate dehydrogenase activity
PVLB_RS07470	COG0135	phosphoribosylanthranilate isomerase activity
PVLB_RS07475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PVLB_RS07480	COG0285	dihydrofolate synthase activity
PVLB_RS07490	COG1286	toxin biosynthetic process
PVLB_RS07545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PVLB_RS07550	COG3188	usher protein
PVLB_RS07555	COG3121	Chaperone
PVLB_RS07565	COG2197	response regulator
PVLB_RS07575	COG2199	diguanylate cyclase activity
PVLB_RS07575	COG2202	Pas domain
PVLB_RS07575	COG2200	EAL domain
PVLB_RS07590	COG3121	Chaperone
PVLB_RS07600	COG0446	pyridine nucleotide-disulphide oxidoreductase
PVLB_RS07600	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS07610	COG3038	cytochrome b561
PVLB_RS07625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PVLB_RS07630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PVLB_RS07635	COG0705	Rhomboid family
PVLB_RS07650	COG0308	aminopeptidase N
PVLB_RS07670	COG2706	6-phosphogluconolactonase activity
PVLB_RS07690	COG0420	3'-5' exonuclease activity
PVLB_RS07720	COG0714	Associated with various cellular activities
PVLB_RS07740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PVLB_RS07755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PVLB_RS07770	COG0668	transmembrane transport
PVLB_RS07790	COG2815	serine threonine protein kinase
PVLB_RS07790	COG0515	serine threonine protein kinase
PVLB_RS07795	COG2223	nitrite transmembrane transporter activity
PVLB_RS07800	COG3707	response regulator
PVLB_RS07805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PVLB_RS07810	COG0167	dihydroorotate dehydrogenase activity
PVLB_RS07815	COG0116	Belongs to the methyltransferase superfamily
PVLB_RS07815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PVLB_RS07825	COG2027	D-alanyl-D-alanine carboxypeptidase
PVLB_RS07830	COG3171	Protein conserved in bacteria
PVLB_RS07835	COG2205	protein histidine kinase activity
PVLB_RS07835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS07840	COG2197	response regulator
PVLB_RS07865	COG0004	ammonium transporteR
PVLB_RS07885	COG0840	transmembrane signaling receptor activity
PVLB_RS07895	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PVLB_RS07900	COG0425	Belongs to the sulfur carrier protein TusA family
PVLB_RS07905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PVLB_RS07910	COG1132	(ABC) transporter
PVLB_RS07935	COG0521	Mo-molybdopterin cofactor biosynthetic process
PVLB_RS07955	COG1597	lipid kinase activity
PVLB_RS07960	COG2197	response regulator
PVLB_RS07965	COG3851	Histidine kinase
PVLB_RS07975	COG0835	chemotaxis
PVLB_RS07975	COG0784	Response regulator, receiver
PVLB_RS07985	COG0741	lytic transglycosylase activity
PVLB_RS07990	COG0488	(ABC) transporter
PVLB_RS07995	COG0589	response to stress
PVLB_RS08005	COG1024	Enoyl-CoA hydratase
PVLB_RS08005	COG1250	3-hydroxyacyl-CoA dehydrogenase
PVLB_RS08010	COG0183	Belongs to the thiolase family
PVLB_RS08040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PVLB_RS08060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PVLB_RS08070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PVLB_RS08080	COG1477	protein flavinylation
PVLB_RS08085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PVLB_RS08090	COG0584	glycerophosphoryl diester phosphodiesterase
PVLB_RS08100	COG4591	ABC-type transport system involved in lipoprotein release permease component
PVLB_RS08105	COG1136	(ABC) transporter
PVLB_RS08110	COG4591	ABC-type transport system involved in lipoprotein release permease component
PVLB_RS08125	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PVLB_RS08125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PVLB_RS08140	COG2853	Lipoprotein
PVLB_RS08150	COG4566	intracellular signal transduction
PVLB_RS08165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PVLB_RS08170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PVLB_RS08195	COG3383	formate dehydrogenase (NAD+) activity
PVLB_RS08245	COG0730	response to heat
PVLB_RS08250	COG0840	transmembrane signaling receptor activity
PVLB_RS08255	COG0583	DNA-binding transcription factor activity
PVLB_RS08275	COG2186	Transcriptional regulator
PVLB_RS08290	COG0840	transmembrane signaling receptor activity
PVLB_RS08305	COG2423	ornithine cyclodeaminase activity
PVLB_RS08315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PVLB_RS08350	COG0544	peptidyl-prolyl cis-trans isomerase activity
PVLB_RS08355	COG0740	serine-type endopeptidase activity
PVLB_RS08360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PVLB_RS08365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PVLB_RS08375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PVLB_RS08415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PVLB_RS08420	COG2259	Doxx family
PVLB_RS08430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PVLB_RS08435	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PVLB_RS08440	COG4181	ATPase activity
PVLB_RS08475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PVLB_RS08480	COG0589	response to stress
PVLB_RS08510	COG0189	ligase activity
PVLB_RS08510	COG4067	protein conserved in archaea
PVLB_RS08515	COG1802	Transcriptional regulator
PVLB_RS08525	COG0372	Belongs to the citrate synthase family
PVLB_RS08540	COG2079	MmgE PrpD family protein
PVLB_RS08555	COG0720	synthase
PVLB_RS08585	COG0517	IMP dehydrogenase activity
PVLB_RS08585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PVLB_RS08585	COG0617	tRNA 3'-terminal CCA addition
PVLB_RS08600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PVLB_RS08625	COG4251	negative regulation of phosphorylation
PVLB_RS08665	COG2866	Carboxypeptidase
PVLB_RS08695	COG1396	sequence-specific DNA binding
PVLB_RS08700	COG0174	glutamine synthetase
PVLB_RS08705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PVLB_RS08720	COG4172	Belongs to the ABC transporter superfamily
PVLB_RS08725	COG4239	(ABC) transporter, permease
PVLB_RS08730	COG4174	ABC transporter (Permease)
PVLB_RS08735	COG4166	transmembrane transport
PVLB_RS08740	COG4166	transmembrane transport
PVLB_RS08745	COG0741	lytic transglycosylase activity
PVLB_RS08745	COG1388	LysM domain
PVLB_RS08750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PVLB_RS08760	COG0328	RNA-DNA hybrid ribonuclease activity
PVLB_RS08765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PVLB_RS08780	COG0431	NADPH-dependent FMN reductase
PVLB_RS08785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PVLB_RS08790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PVLB_RS08795	COG0583	DNA-binding transcription factor activity
PVLB_RS08810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PVLB_RS08820	COG0183	Belongs to the thiolase family
PVLB_RS08825	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS08830	COG1024	Enoyl-CoA hydratase
PVLB_RS08855	COG1320	monovalent cation:proton antiporter activity
PVLB_RS08860	COG2212	antiporter activity
PVLB_RS08870	COG0651	ATP synthesis coupled electron transport
PVLB_RS08875	COG1006	Multisubunit Na H antiporter MnhC subunit
PVLB_RS08880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PVLB_RS08880	COG2111	Na H antiporter
PVLB_RS08895	COG1335	isochorismatase
PVLB_RS08965	COG0589	response to stress
PVLB_RS09005	COG0583	DNA-binding transcription factor activity
PVLB_RS09015	COG0010	Belongs to the arginase family
PVLB_RS09025	COG2133	pyrroloquinoline quinone binding
PVLB_RS09045	COG1278	Cold shock
PVLB_RS09055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PVLB_RS09060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PVLB_RS09065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PVLB_RS09070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PVLB_RS09075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PVLB_RS09080	COG0072	phenylalanine-tRNA ligase activity
PVLB_RS09085	COG0776	regulation of translation
PVLB_RS09160	COG0629	single-stranded DNA binding
PVLB_RS09205	COG0305	Participates in initiation and elongation during chromosome replication
PVLB_RS09225	COG0582	viral genome integration into host DNA
PVLB_RS09270	COG4626	Terminase
PVLB_RS09270	COG1802	Transcriptional regulator
PVLB_RS09275	COG4695	Portal protein
PVLB_RS09280	COG0740	serine-type endopeptidase activity
PVLB_RS09380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PVLB_RS09820	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PVLB_RS09900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PVLB_RS09945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PVLB_RS09950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PVLB_RS09980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PVLB_RS09985	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
PVLB_RS10000	COG0366	Alpha amylase catalytic
PVLB_RS10005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PVLB_RS10050	COG2204	response regulator
PVLB_RS10125	COG1640	4-alpha-glucanotransferase
PVLB_RS10130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PVLB_RS10135	COG0297	glycogen (starch) synthase activity
PVLB_RS10140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PVLB_RS10145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PVLB_RS10150	COG1309	transcriptional regulator
PVLB_RS10160	COG0493	'glutamate synthase
PVLB_RS10170	COG1953	Uracil, thiamine, allantoin
PVLB_RS10180	COG1234	tRNA 3'-trailer cleavage
PVLB_RS10185	COG3040	lipid binding
PVLB_RS10190	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PVLB_RS10195	COG1024	Enoyl-CoA hydratase
PVLB_RS10200	COG2816	NAD+ diphosphatase activity
PVLB_RS10205	COG0730	response to heat
PVLB_RS10210	COG1104	cysteine desulfurase activity
PVLB_RS10225	COG1418	mRNA catabolic process
PVLB_RS10230	COG0861	Integral membrane protein TerC family
PVLB_RS10235	COG1414	Transcriptional regulator
PVLB_RS10240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS10245	COG0765	amino acid transport
PVLB_RS10250	COG1126	abc transporter atp-binding protein
PVLB_RS10255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS10265	COG3842	ATPase activity
PVLB_RS10270	COG1177	transmembrane transport
PVLB_RS10275	COG1176	ABC-type spermidine putrescine transport system, permease component I
PVLB_RS10285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PVLB_RS10295	COG1741	Belongs to the pirin family
PVLB_RS10310	COG0583	DNA-binding transcription factor activity
PVLB_RS10315	COG0583	DNA-binding transcription factor activity
PVLB_RS10320	COG0477	Major facilitator Superfamily
PVLB_RS10335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PVLB_RS10345	COG4106	trans-aconitate 2-methyltransferase activity
PVLB_RS10360	COG0625	glutathione transferase activity
PVLB_RS10370	COG0393	Putative heavy-metal-binding
PVLB_RS10415	COG4221	oxidoreductase activity
PVLB_RS10430	COG1396	sequence-specific DNA binding
PVLB_RS10430	COG1917	Cupin 2, conserved barrel domain protein
PVLB_RS10435	COG0477	Major facilitator Superfamily
PVLB_RS10440	COG3038	cytochrome b561
PVLB_RS10445	COG0753	catalase activity
PVLB_RS10460	COG0708	Exodeoxyribonuclease III
PVLB_RS10470	COG0729	surface antigen
PVLB_RS10485	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS10495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PVLB_RS10495	COG2010	Cytochrome c
PVLB_RS10500	COG2080	2 iron, 2 sulfur cluster binding
PVLB_RS10505	COG2010	Cytochrome c
PVLB_RS10505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PVLB_RS10510	COG2814	Major facilitator Superfamily
PVLB_RS10515	COG0583	DNA-binding transcription factor activity
PVLB_RS10545	COG2366	antibiotic biosynthetic process
PVLB_RS10550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PVLB_RS10560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PVLB_RS10565	COG0215	cysteine-tRNA ligase activity
PVLB_RS10575	COG0745	RESPONSE REGULATOR receiver
PVLB_RS10605	COG3675	Pfam Lipase (class 3)
PVLB_RS10610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PVLB_RS10620	COG0583	DNA-binding transcription factor activity
PVLB_RS10630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PVLB_RS10635	COG0583	DNA-binding transcription factor activity
PVLB_RS10655	COG3180	Ammonia monooxygenase
PVLB_RS10670	COG0768	penicillin binding
PVLB_RS10675	COG0471	metal ion transport
PVLB_RS10680	COG1064	alcohol dehydrogenase
PVLB_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS10690	COG1177	transmembrane transport
PVLB_RS10695	COG1176	ABC-type spermidine putrescine transport system, permease component I
PVLB_RS10700	COG3842	ATPase activity
PVLB_RS10705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PVLB_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS10715	COG0583	DNA-binding transcription factor activity
PVLB_RS10720	COG0583	DNA-binding transcription factor activity
PVLB_RS10725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PVLB_RS10730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PVLB_RS10765	COG1472	Belongs to the glycosyl hydrolase 3 family
PVLB_RS10785	COG2814	Major facilitator Superfamily
PVLB_RS10790	COG2814	Major facilitator Superfamily
PVLB_RS10810	COG0673	inositol 2-dehydrogenase activity
PVLB_RS10845	COG1473	amidohydrolase
PVLB_RS10850	COG0039	L-malate dehydrogenase activity
PVLB_RS10870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PVLB_RS10875	COG0765	amino acid transport
PVLB_RS10880	COG0765	amino acid transport
PVLB_RS10885	COG1126	abc transporter atp-binding protein
PVLB_RS10925	COG1120	ATPase activity
PVLB_RS10930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PVLB_RS10945	COG0113	porphobilinogen synthase activity
PVLB_RS10955	COG0307	riboflavin synthase, alpha
PVLB_RS10965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PVLB_RS10975	COG1984	allophanate hydrolase subunit 2
PVLB_RS10990	COG0583	DNA-binding transcription factor activity
PVLB_RS11000	COG4106	trans-aconitate 2-methyltransferase activity
PVLB_RS11010	COG0019	diaminopimelate decarboxylase activity
PVLB_RS11020	COG0583	DNA-binding transcription factor activity
PVLB_RS11025	COG2271	Major facilitator Superfamily
PVLB_RS11030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS11035	COG0217	transcriptional regulatory protein
PVLB_RS11045	COG0076	glutamate decarboxylase activity
PVLB_RS11050	COG0477	Major facilitator Superfamily
PVLB_RS11060	COG3185	4-Hydroxyphenylpyruvate dioxygenase
PVLB_RS11060	COG1082	Xylose isomerase domain protein TIM barrel
PVLB_RS11065	COG1309	transcriptional regulator
PVLB_RS11090	COG5001	Diguanylate cyclase
PVLB_RS11095	COG0656	L-ascorbic acid biosynthetic process
PVLB_RS11115	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PVLB_RS11130	COG0477	Major facilitator Superfamily
PVLB_RS11140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PVLB_RS11145	COG3706	GGDEF domain
PVLB_RS11150	COG1611	Belongs to the LOG family
PVLB_RS11155	COG2855	membrane
PVLB_RS11180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PVLB_RS11185	COG2218	PFAM glutamate synthase alpha subunit domain protein
PVLB_RS11190	COG0069	glutamate synthase activity
PVLB_RS11210	COG2186	Transcriptional regulator
PVLB_RS11215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PVLB_RS11225	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS11230	COG2267	carboxylic ester hydrolase activity
PVLB_RS11240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PVLB_RS11245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PVLB_RS11250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PVLB_RS11255	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS11290	COG3209	COG3209 Rhs family protein
PVLB_RS11315	COG3052	prosthetic group binding
PVLB_RS11335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PVLB_RS11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PVLB_RS11360	COG0235	Class ii aldolase
PVLB_RS11370	COG0583	DNA-binding transcription factor activity
PVLB_RS11380	COG1280	lysine exporter protein (LysE YggA)
PVLB_RS11410	COG0583	DNA-binding transcription factor activity
PVLB_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS11450	COG1944	ATP diphosphatase activity
PVLB_RS11480	COG2391	methyltransferase activity
PVLB_RS11495	COG2186	Transcriptional regulator
PVLB_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS11505	COG2721	sulfolactate sulfo-lyase activity
PVLB_RS11510	COG2271	Major facilitator Superfamily
PVLB_RS11515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PVLB_RS11520	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PVLB_RS11525	COG1126	abc transporter atp-binding protein
PVLB_RS11530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS11560	COG1448	Aminotransferase
PVLB_RS11565	COG0814	amino acid
PVLB_RS11590	COG1538	Outer membrane efflux protein
PVLB_RS11615	COG4974	Belongs to the 'phage' integrase family
PVLB_RS11620	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS11625	COG0784	Response regulator, receiver
PVLB_RS11625	COG4191	Histidine kinase
PVLB_RS11630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PVLB_RS11635	COG0348	domain, Protein
PVLB_RS11640	COG1285	pathogenesis
PVLB_RS11650	COG0789	Transcriptional regulator
PVLB_RS11655	COG2207	Transcriptional regulator
PVLB_RS11665	COG0829	nickel cation binding
PVLB_RS11670	COG0831	urea catabolic process
PVLB_RS11675	COG0832	Belongs to the urease beta subunit family
PVLB_RS11680	COG0804	urea catabolic process
PVLB_RS11685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PVLB_RS11695	COG0830	nickel cation binding
PVLB_RS11700	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PVLB_RS11720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PVLB_RS11725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PVLB_RS11740	COG0587	DNA-directed DNA polymerase activity
PVLB_RS11745	COG0656	L-ascorbic acid biosynthetic process
PVLB_RS11755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PVLB_RS11765	COG2031	fatty acid transporter
PVLB_RS11775	COG2207	Transcriptional regulator
PVLB_RS11795	COG2826	transposase and inactivated derivatives, IS30 family
PVLB_RS11820	COG1476	TRANSCRIPTIONal
PVLB_RS11850	COG1253	flavin adenine dinucleotide binding
PVLB_RS11860	COG2200	EAL domain
PVLB_RS11880	COG0784	Response regulator, receiver
PVLB_RS11880	COG4191	Histidine kinase
PVLB_RS11885	COG0784	Response regulator, receiver
PVLB_RS11885	COG4191	Histidine kinase
PVLB_RS11905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS11925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PVLB_RS11930	COG0826	peptidase U32
PVLB_RS11940	COG2384	SAM-dependent methyltransferase
PVLB_RS11975	COG1473	amidohydrolase
PVLB_RS11985	COG0154	amidase activity
PVLB_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS12005	COG1053	succinate dehydrogenase
PVLB_RS12015	COG2814	Major facilitator Superfamily
PVLB_RS12025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PVLB_RS12030	COG0745	RESPONSE REGULATOR receiver
PVLB_RS12035	COG2205	protein histidine kinase activity
PVLB_RS12050	COG1079	Belongs to the binding-protein-dependent transport system permease family
PVLB_RS12055	COG4603	Belongs to the binding-protein-dependent transport system permease family
PVLB_RS12060	COG3845	ABC transporter
PVLB_RS12070	COG3706	GGDEF domain
PVLB_RS12085	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS12090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PVLB_RS12100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PVLB_RS12155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PVLB_RS12185	COG1045	serine acetyltransferase
PVLB_RS12195	COG2990	Protein conserved in bacteria
PVLB_RS12220	COG0583	DNA-binding transcription factor activity
PVLB_RS12225	COG1760	l-serine dehydratase
PVLB_RS12230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS12240	COG0174	glutamine synthetase
PVLB_RS12255	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS12260	COG0583	DNA-binding transcription factor activity
PVLB_RS12330	COG2814	Major facilitator Superfamily
PVLB_RS12335	COG4948	Mandelate Racemase Muconate Lactonizing
PVLB_RS12340	COG4829	muconolactone delta-isomerase
PVLB_RS12345	COG3485	protocatechuate 3,4-dioxygenase
PVLB_RS12350	COG3135	benzoate transporter
PVLB_RS12365	COG0667	Aldo Keto reductase
PVLB_RS12370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PVLB_RS12375	COG2271	Major facilitator Superfamily
PVLB_RS12390	COG3835	regulator
PVLB_RS12395	COG1929	Belongs to the glycerate kinase type-1 family
PVLB_RS12425	COG0154	amidase activity
PVLB_RS12430	COG0367	asparagine synthase
PVLB_RS12435	COG0583	DNA-binding transcription factor activity
PVLB_RS12440	COG3386	PFAM SMP-30 Gluconolaconase
PVLB_RS12450	COG1999	signal sequence binding
PVLB_RS12460	COG0004	ammonium transporteR
PVLB_RS12465	COG0347	Belongs to the P(II) protein family
PVLB_RS12470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PVLB_RS12475	COG0492	ferredoxin-NADP+ reductase activity
PVLB_RS12480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PVLB_RS12490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PVLB_RS12510	COG2197	response regulator
PVLB_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS12525	COG1942	4-Oxalocrotonate Tautomerase
PVLB_RS12540	COG0583	DNA-binding transcription factor activity
PVLB_RS12545	COG2814	Major facilitator Superfamily
PVLB_RS12585	COG2837	iron assimilation
PVLB_RS12605	COG2194	sulfuric ester hydrolase activity
PVLB_RS12620	COG2030	dehydratase
PVLB_RS12620	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS12635	COG3162	membrane
PVLB_RS12640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PVLB_RS12645	COG2151	metal-sulfur cluster biosynthetic enzyme
PVLB_RS12650	COG3396	Phenylacetate-CoA oxygenase
PVLB_RS12655	COG3460	Phenylacetate-CoA oxygenase
PVLB_RS12660	COG3396	Phenylacetate-CoA oxygenase
PVLB_RS12670	COG0183	Belongs to the thiolase family
PVLB_RS12675	COG2050	protein possibly involved in aromatic compounds catabolism
PVLB_RS12680	COG1250	3-hydroxyacyl-CoA dehydrogenase
PVLB_RS12685	COG1024	Enoyl-CoA hydratase
PVLB_RS12690	COG1024	Enoyl-CoA hydratase
PVLB_RS12700	COG3327	negative regulation of DNA-templated transcription, initiation
PVLB_RS12720	COG4977	sequence-specific DNA binding
PVLB_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS12730	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PVLB_RS12760	COG0183	Belongs to the thiolase family
PVLB_RS12765	COG0824	Thioesterase
PVLB_RS12770	COG1454	alcohol dehydrogenase
PVLB_RS12775	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS12780	COG1250	3-hydroxyacyl-CoA dehydrogenase
PVLB_RS12780	COG1024	Enoyl-CoA hydratase
PVLB_RS12785	COG0583	DNA-binding transcription factor activity
PVLB_RS12790	COG2015	COG2015, Alkyl sulfatase and related hydrolases
PVLB_RS12820	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS12825	COG0318	PFAM AMP-dependent synthetase and ligase
PVLB_RS12835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PVLB_RS12840	COG2814	Major facilitator Superfamily
PVLB_RS12845	COG2356	endonuclease I
PVLB_RS12865	COG2205	protein histidine kinase activity
PVLB_RS12870	COG0745	RESPONSE REGULATOR receiver
PVLB_RS12875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS12885	COG0746	molybdenum cofactor guanylyltransferase activity
PVLB_RS12930	COG1132	(ABC) transporter
PVLB_RS12935	COG3284	Transcriptional regulator
PVLB_RS12960	COG3145	DNA-N1-methyladenine dioxygenase activity
PVLB_RS12985	COG2165	general secretion pathway protein
PVLB_RS12990	COG2165	general secretion pathway protein
PVLB_RS12995	COG4796	Type ii and iii secretion system protein
PVLB_RS13020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PVLB_RS13025	COG2204	response regulator
PVLB_RS13100	COG3209	COG3209 Rhs family protein
PVLB_RS13135	COG1414	Transcriptional regulator
PVLB_RS13140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PVLB_RS13145	COG1053	succinate dehydrogenase
PVLB_RS13155	COG1053	succinate dehydrogenase
PVLB_RS13160	COG2271	Major facilitator Superfamily
PVLB_RS13180	COG1053	succinate dehydrogenase
PVLB_RS13215	COG3008	intermembrane lipid transfer
PVLB_RS13220	COG2995	paraquat-inducible protein a
PVLB_RS13285	COG4106	trans-aconitate 2-methyltransferase activity
PVLB_RS13295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PVLB_RS13305	COG3257	ureidoglycine aminohydrolase activity
PVLB_RS13330	COG1522	sequence-specific DNA binding
PVLB_RS13350	COG1959	2 iron, 2 sulfur cluster binding
PVLB_RS13365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PVLB_RS13370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PVLB_RS13375	COG4166	transmembrane transport
PVLB_RS13380	COG4174	ABC transporter (Permease)
PVLB_RS13385	COG4239	(ABC) transporter, permease
PVLB_RS13390	COG3290	protein histidine kinase activity
PVLB_RS13390	COG3829	transcription factor binding
PVLB_RS13395	COG2610	gluconate transmembrane transporter activity
PVLB_RS13400	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS13405	COG4574	serine-type endopeptidase inhibitor activity
PVLB_RS13410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PVLB_RS13415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PVLB_RS13435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PVLB_RS13450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PVLB_RS13460	COG2135	peptidase activity
PVLB_RS13500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PVLB_RS13505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PVLB_RS13510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PVLB_RS13525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PVLB_RS13545	COG2199	diguanylate cyclase activity
PVLB_RS13545	COG3287	FIST C domain
PVLB_RS13545	COG2200	EAL domain
PVLB_RS13560	COG1230	cation diffusion facilitator family transporter
PVLB_RS13575	COG0488	(ABC) transporter
PVLB_RS13590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PVLB_RS13610	COG1968	undecaprenyl-diphosphatase activity
PVLB_RS13615	COG0840	transmembrane signaling receptor activity
PVLB_RS13665	COG2204	response regulator
PVLB_RS13715	COG2197	response regulator
PVLB_RS13720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS13720	COG2205	protein histidine kinase activity
PVLB_RS13730	COG1609	Transcriptional regulator
PVLB_RS13745	COG2204	response regulator
PVLB_RS13750	COG5002	protein histidine kinase activity
PVLB_RS13755	COG5002	protein histidine kinase activity
PVLB_RS13760	COG0739	heme binding
PVLB_RS13760	COG0741	lytic transglycosylase activity
PVLB_RS13760	COG1196	nuclear chromosome segregation
PVLB_RS13770	COG1459	type II secretion system
PVLB_RS13775	COG2814	Major facilitator Superfamily
PVLB_RS13780	COG1566	PFAM secretion protein HlyD family protein
PVLB_RS13785	COG1846	Transcriptional regulator
PVLB_RS13790	COG4566	intracellular signal transduction
PVLB_RS13800	COG0318	PFAM AMP-dependent synthetase and ligase
PVLB_RS13805	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS13815	COG2056	Na+-H+ antiporter family
PVLB_RS13820	COG0840	transmembrane signaling receptor activity
PVLB_RS13845	COG1280	lysine exporter protein (LysE YggA)
PVLB_RS13850	COG0583	DNA-binding transcription factor activity
PVLB_RS13870	COG0346	lactoylglutathione lyase activity
PVLB_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS13915	COG0477	Major facilitator Superfamily
PVLB_RS13920	COG0346	lactoylglutathione lyase activity
PVLB_RS13925	COG0596	Alpha beta hydrolase
PVLB_RS13935	COG0210	DNA helicase
PVLB_RS13950	COG1199	ATP-dependent helicase activity
PVLB_RS13950	COG1199	ATP-dependent helicase activity
PVLB_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS13970	COG3321	synthase
PVLB_RS13970	COG0604	alcohol dehydrogenase
PVLB_RS14030	COG0583	DNA-binding transcription factor activity
PVLB_RS14035	COG0288	reversible hydration of carbon dioxide
PVLB_RS14040	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PVLB_RS14070	COG2851	Citrate transporter
PVLB_RS14075	COG1301	dicarboxylic acid transport
PVLB_RS14080	COG2828	Protein conserved in bacteria
PVLB_RS14085	COG0583	DNA-binding transcription factor activity
PVLB_RS14110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PVLB_RS14120	COG0708	Exodeoxyribonuclease III
PVLB_RS14125	COG0583	DNA-binding transcription factor activity
PVLB_RS14130	COG0604	alcohol dehydrogenase
PVLB_RS14130	COG3321	synthase
PVLB_RS14130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PVLB_RS14130	COG4221	oxidoreductase activity
PVLB_RS14145	COG0583	DNA-binding transcription factor activity
PVLB_RS14175	COG3712	iron ion homeostasis
PVLB_RS14185	COG2249	NAD(P)H dehydrogenase (quinone) activity
PVLB_RS14220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PVLB_RS14235	COG2351	hydroxyisourate hydrolase activity
PVLB_RS14245	COG2233	PERMEase
PVLB_RS14250	COG0583	DNA-binding transcription factor activity
PVLB_RS14270	COG0668	transmembrane transport
PVLB_RS14275	COG0789	Transcriptional regulator
PVLB_RS14280	COG2202	Pas domain
PVLB_RS14280	COG1366	Belongs to the anti-sigma-factor antagonist family
PVLB_RS14305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PVLB_RS14315	COG3046	protein related to deoxyribodipyrimidine photolyase
PVLB_RS14330	COG0640	Transcriptional regulator
PVLB_RS14335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PVLB_RS14370	COG0531	amino acid
PVLB_RS14380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PVLB_RS14390	COG0589	response to stress
PVLB_RS14400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PVLB_RS14405	COG0589	response to stress
PVLB_RS14410	COG0459	protein refolding
PVLB_RS14415	COG2217	Heavy metal translocating P-type atpase
PVLB_RS14430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PVLB_RS14440	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PVLB_RS14450	COG0071	Belongs to the small heat shock protein (HSP20) family
PVLB_RS14495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PVLB_RS14520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PVLB_RS14530	COG0693	protein deglycase activity
PVLB_RS14535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
PVLB_RS14540	COG2890	protein-(glutamine-N5) methyltransferase activity
PVLB_RS14580	COG3568	Endonuclease Exonuclease Phosphatase
PVLB_RS14585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PVLB_RS14590	COG0392	lysyltransferase activity
PVLB_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS14680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PVLB_RS14685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PVLB_RS14710	COG4974	Belongs to the 'phage' integrase family
PVLB_RS14730	COG0861	Integral membrane protein TerC family
PVLB_RS14755	COG2259	Doxx family
PVLB_RS14770	COG3220	belongs to the UPF0276 family
PVLB_RS14790	COG0417	DNA replication proofreading
PVLB_RS14795	COG0583	DNA-binding transcription factor activity
PVLB_RS14845	COG1999	signal sequence binding
PVLB_RS14850	COG0316	Belongs to the HesB IscA family
PVLB_RS14850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PVLB_RS14855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PVLB_RS14875	COG1879	ABC-type sugar transport system periplasmic component
PVLB_RS14895	COG0656	L-ascorbic acid biosynthetic process
PVLB_RS14900	COG2814	Major facilitator Superfamily
PVLB_RS14940	COG2168	tRNA wobble position uridine thiolation
PVLB_RS14950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PVLB_RS14955	COG0435	Glutathione S-transferase
PVLB_RS14960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PVLB_RS14960	COG1648	precorrin-2 dehydrogenase activity
PVLB_RS14965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PVLB_RS14970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PVLB_RS14975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PVLB_RS14980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PVLB_RS14985	COG1674	ftsk spoiiie
PVLB_RS14990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PVLB_RS14995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PVLB_RS15000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PVLB_RS15005	COG0542	response to heat
PVLB_RS15010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PVLB_RS15015	COG1278	Cold shock
PVLB_RS15035	COG0482	sulfurtransferase activity
PVLB_RS15040	COG2915	High frequency lysogenization protein hflD homolog
PVLB_RS15050	COG2850	peptidyl-arginine hydroxylation
PVLB_RS15055	COG2153	protein acetylation
PVLB_RS15065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS15085	COG0583	DNA-binding transcription factor activity
PVLB_RS15100	COG2814	Major facilitator Superfamily
PVLB_RS15105	COG1064	alcohol dehydrogenase
PVLB_RS15110	COG2207	Transcriptional regulator
PVLB_RS15125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PVLB_RS15135	COG4774	siderophore transport
PVLB_RS15150	COG3064	Membrane
PVLB_RS15175	COG2186	Transcriptional regulator
PVLB_RS15180	COG0277	FAD linked oxidase domain protein
PVLB_RS15185	COG0277	FAD linked oxidase domain protein
PVLB_RS15190	COG0247	lactate metabolic process
PVLB_RS15195	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PVLB_RS15200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PVLB_RS15215	COG2807	transmembrane transport
PVLB_RS15220	COG0590	tRNA wobble adenosine to inosine editing
PVLB_RS15225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PVLB_RS15235	COG0183	Belongs to the thiolase family
PVLB_RS15240	COG1250	3-hydroxyacyl-CoA dehydrogenase
PVLB_RS15250	COG2205	protein histidine kinase activity
PVLB_RS15250	COG0784	Response regulator, receiver
PVLB_RS15250	COG2198	Histidine kinase
PVLB_RS15250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS15255	COG0784	Response regulator, receiver
PVLB_RS15255	COG2205	protein histidine kinase activity
PVLB_RS15255	COG5002	protein histidine kinase activity
PVLB_RS15265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PVLB_RS15305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PVLB_RS15315	COG2066	Belongs to the glutaminase family
PVLB_RS15320	COG1686	Belongs to the peptidase S11 family
PVLB_RS15360	COG1121	(ABC) transporter
PVLB_RS15365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PVLB_RS15405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PVLB_RS15420	COG0446	pyridine nucleotide-disulphide oxidoreductase
PVLB_RS15420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PVLB_RS15430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PVLB_RS15440	COG0583	DNA-binding transcription factor activity
PVLB_RS15455	COG0402	S-adenosylhomocysteine deaminase activity
PVLB_RS15465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PVLB_RS15500	COG0583	DNA-binding transcription factor activity
PVLB_RS15520	COG0322	excinuclease ABC activity
PVLB_RS15535	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS15555	COG1696	Membrane protein involved in D-alanine export
PVLB_RS15600	COG0306	phosphate transporter
PVLB_RS15605	COG0625	glutathione transferase activity
PVLB_RS15610	COG2050	protein possibly involved in aromatic compounds catabolism
PVLB_RS15610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PVLB_RS15615	COG1113	amino acid transport
PVLB_RS15620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PVLB_RS15635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PVLB_RS15640	COG0659	secondary active sulfate transmembrane transporter activity
PVLB_RS15660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PVLB_RS15665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PVLB_RS15670	COG0649	NAD binding
PVLB_RS15670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PVLB_RS15685	COG1034	ATP synthesis coupled electron transport
PVLB_RS15690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PVLB_RS15695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PVLB_RS15705	COG0713	ATP synthesis coupled electron transport
PVLB_RS15720	COG1007	ATP synthesis coupled electron transport
PVLB_RS15755	COG0826	peptidase U32
PVLB_RS15765	COG1238	metal cluster binding
PVLB_RS15770	COG0596	Alpha beta hydrolase
PVLB_RS15780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PVLB_RS15785	COG1869	D-ribose catabolic process
PVLB_RS15790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PVLB_RS15795	COG1609	Transcriptional regulator
PVLB_RS15800	COG1172	Belongs to the binding-protein-dependent transport system permease family
PVLB_RS15805	COG1129	ABC transporter
PVLB_RS15815	COG0252	asparaginase activity
PVLB_RS15825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PVLB_RS15845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS15860	COG1253	flavin adenine dinucleotide binding
PVLB_RS15870	COG0583	DNA-binding transcription factor activity
PVLB_RS15875	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PVLB_RS15880	COG3132	Protein of unknown function, DUF480
PVLB_RS15910	COG3634	alkyl hydroperoxide reductase activity
PVLB_RS15935	COG3258	Cytochrome c
PVLB_RS15940	COG2863	cytochrome
PVLB_RS15970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PVLB_RS15980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PVLB_RS15985	COG0745	RESPONSE REGULATOR receiver
PVLB_RS15990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PVLB_RS15995	COG4191	Histidine kinase
PVLB_RS15995	COG0784	Response regulator, receiver
PVLB_RS16010	COG2259	Doxx family
PVLB_RS16025	COG0616	signal peptide processing
PVLB_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS16050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PVLB_RS16075	COG0471	metal ion transport
PVLB_RS16075	COG0490	domain, Protein
PVLB_RS16080	COG2199	diguanylate cyclase activity
PVLB_RS16100	COG0840	transmembrane signaling receptor activity
PVLB_RS16110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PVLB_RS16130	COG1309	transcriptional regulator
PVLB_RS16135	COG0604	alcohol dehydrogenase
PVLB_RS16150	COG2233	PERMEase
PVLB_RS16155	COG2223	nitrite transmembrane transporter activity
PVLB_RS16160	COG2207	Transcriptional regulator
PVLB_RS16165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PVLB_RS16170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PVLB_RS16185	COG1131	(ABC) transporter
PVLB_RS16190	COG0842	Transport permease protein
PVLB_RS16195	COG0842	Transport permease protein
PVLB_RS16205	COG0745	RESPONSE REGULATOR receiver
PVLB_RS16210	COG2205	protein histidine kinase activity
PVLB_RS16215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PVLB_RS16225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PVLB_RS16235	COG0628	permease
PVLB_RS16270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PVLB_RS16285	COG3437	response regulator, receiver
PVLB_RS16285	COG3850	Histidine kinase
PVLB_RS16285	COG2205	protein histidine kinase activity
PVLB_RS16285	COG4999	Histidine kinase
PVLB_RS16290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PVLB_RS16305	COG1741	Belongs to the pirin family
PVLB_RS16315	COG0326	Molecular chaperone. Has ATPase activity
PVLB_RS16350	COG0045	succinate-CoA ligase (ADP-forming) activity
PVLB_RS16355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PVLB_RS16375	COG1053	succinate dehydrogenase
PVLB_RS16380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PVLB_RS16385	COG2009	succinate dehydrogenase
PVLB_RS16410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PVLB_RS16415	COG3047	cAMP biosynthetic process
PVLB_RS16415	COG2885	chlorophyll binding
PVLB_RS16455	COG2198	Histidine kinase
PVLB_RS16455	COG0784	Response regulator, receiver
PVLB_RS16455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS16455	COG2205	protein histidine kinase activity
PVLB_RS16465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS16470	COG0577	efflux transmembrane transporter activity
PVLB_RS16470	COG1136	(ABC) transporter
PVLB_RS16475	COG1538	Outer membrane efflux protein
PVLB_RS16545	COG0642	Histidine kinase
PVLB_RS16560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PVLB_RS16595	COG3123	guanosine phosphorylase activity
PVLB_RS16605	COG3278	Belongs to the heme-copper respiratory oxidase family
PVLB_RS16620	COG2010	Cytochrome c
PVLB_RS16625	COG3278	Belongs to the heme-copper respiratory oxidase family
PVLB_RS16640	COG2010	Cytochrome c
PVLB_RS16645	COG0348	domain, Protein
PVLB_RS16655	COG2217	Heavy metal translocating P-type atpase
PVLB_RS16675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PVLB_RS16680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PVLB_RS16685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PVLB_RS16690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PVLB_RS16695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PVLB_RS16765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PVLB_RS16770	COG3115	cell septum assembly
PVLB_RS16800	COG0402	S-adenosylhomocysteine deaminase activity
PVLB_RS16810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PVLB_RS16820	COG2252	PERMEase
PVLB_RS16840	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PVLB_RS16850	COG2233	PERMEase
PVLB_RS16870	COG1368	sulfuric ester hydrolase activity
PVLB_RS16875	COG2354	Protein conserved in bacteria
PVLB_RS16890	COG3960	tartronate-semialdehyde synthase activity
PVLB_RS16895	COG3622	Belongs to the hyi family
PVLB_RS16900	COG2084	Dehydrogenase
PVLB_RS16910	COG0469	pyruvate kinase activity
PVLB_RS16915	COG4413	Urea transporter
PVLB_RS16920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PVLB_RS16930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PVLB_RS16930	COG0116	Belongs to the methyltransferase superfamily
PVLB_RS16940	COG1522	sequence-specific DNA binding
PVLB_RS16945	COG1953	Uracil, thiamine, allantoin
PVLB_RS17040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PVLB_RS17065	COG1138	Cytochrome C-type biogenesis protein
PVLB_RS17070	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PVLB_RS17090	COG4133	protoheme IX ABC transporter activity
PVLB_RS17105	COG2257	FlhB HrpN YscU SpaS Family
PVLB_RS17120	COG0835	chemotaxis
PVLB_RS17130	COG1192	Involved in chromosome partitioning
PVLB_RS17135	COG1360	Flagellar Motor Protein
PVLB_RS17140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PVLB_RS17145	COG2201	protein-glutamate methylesterase activity
PVLB_RS17150	COG0643	Histidine kinase
PVLB_RS17150	COG0784	Response regulator, receiver
PVLB_RS17150	COG2198	Histidine kinase
PVLB_RS17155	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PVLB_RS17180	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PVLB_RS17245	COG2882	bacterial-type flagellum organization
PVLB_RS17270	COG1677	Flagellar hook-basal body complex protein FliE
PVLB_RS17310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PVLB_RS17325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PVLB_RS17330	COG2089	acid synthase
PVLB_RS17335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PVLB_RS17340	COG1083	cytidylyl-transferase
PVLB_RS17345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PVLB_RS17350	COG1086	Polysaccharide biosynthesis protein
PVLB_RS17355	COG0438	transferase activity, transferring glycosyl groups
PVLB_RS17355	COG1216	Glycosyl transferase, family 2
PVLB_RS17380	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PVLB_RS17390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PVLB_RS17395	COG0438	transferase activity, transferring glycosyl groups
PVLB_RS17395	COG1216	Glycosyl transferase, family 2
PVLB_RS17405	COG1256	bacterial-type flagellum assembly
PVLB_RS17415	COG1706	bacterial-type flagellum-dependent cell motility
PVLB_RS17420	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PVLB_RS17430	COG4787	bacterial-type flagellum-dependent cell motility
PVLB_RS17440	COG1749	Flagellar hook protein flgE
PVLB_RS17455	COG1815	bacterial-type flagellum-dependent cell motility
PVLB_RS17460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PVLB_RS17465	COG0784	Response regulator, receiver
PVLB_RS17465	COG0835	chemotaxis
PVLB_RS17485	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PVLB_RS17495	COG0477	Major facilitator Superfamily
PVLB_RS17505	COG1522	sequence-specific DNA binding
PVLB_RS17510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PVLB_RS17515	COG0022	dehydrogenase e1 component
PVLB_RS17525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PVLB_RS17560	COG2239	Acts as a magnesium transporter
PVLB_RS17590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PVLB_RS17595	COG0527	aspartate kinase activity
PVLB_RS17600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PVLB_RS17605	COG2988	succinylglutamate desuccinylase activity
PVLB_RS17615	COG3724	N-succinylarginine dihydrolase activity
PVLB_RS17620	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS17635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PVLB_RS17660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS17665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PVLB_RS17685	COG2154	pterin-4-alpha-carbinolamine dehydratase
PVLB_RS17695	COG0277	FAD linked oxidase domain protein
PVLB_RS17695	COG0247	lactate metabolic process
PVLB_RS17700	COG0583	DNA-binding transcription factor activity
PVLB_RS17705	COG1113	amino acid transport
PVLB_RS17715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PVLB_RS17725	COG0009	L-threonylcarbamoyladenylate synthase
PVLB_RS17730	COG0613	PHP domain protein
PVLB_RS17735	COG2917	probably involved in intracellular septation
PVLB_RS17740	COG2350	Protein conserved in bacteria
PVLB_RS17750	COG0745	RESPONSE REGULATOR receiver
PVLB_RS17760	COG0642	Histidine kinase
PVLB_RS17765	COG0778	Nitroreductase
PVLB_RS17770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PVLB_RS17790	COG2207	Transcriptional regulator
PVLB_RS17805	COG1752	Esterase of the alpha-beta hydrolase superfamily
PVLB_RS17815	COG0514	ATP-dependent DNA helicase (RecQ)
PVLB_RS17825	COG2832	Protein of unknown function (DUF454)
PVLB_RS17845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS17870	COG1305	Transglutaminase-like
PVLB_RS17880	COG2308	Evidence 4 Homologs of previously reported genes of
PVLB_RS17890	COG0840	transmembrane signaling receptor activity
PVLB_RS17905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PVLB_RS17910	COG0583	DNA-binding transcription factor activity
PVLB_RS17920	COG0697	spore germination
PVLB_RS17930	COG0513	Belongs to the DEAD box helicase family
PVLB_RS18000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PVLB_RS18045	COG0210	DNA helicase
PVLB_RS18055	COG1204	response to ionizing radiation
PVLB_RS18105	COG0668	transmembrane transport
PVLB_RS18115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PVLB_RS18130	COG2267	carboxylic ester hydrolase activity
PVLB_RS18140	COG1132	(ABC) transporter
PVLB_RS18150	COG2188	Transcriptional regulator
PVLB_RS18160	COG1643	Atp-dependent helicase
PVLB_RS18170	COG0174	glutamine synthetase
PVLB_RS18175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS18180	COG0318	PFAM AMP-dependent synthetase and ligase
PVLB_RS18195	COG2030	dehydratase
PVLB_RS18200	COG4941	Belongs to the sigma-70 factor family
PVLB_RS18210	COG3795	YCII-related domain
PVLB_RS18230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PVLB_RS18235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PVLB_RS18250	COG0242	peptide deformylase activity
PVLB_RS18255	COG1295	ribonuclease BN
PVLB_RS18265	COG3420	alginic acid biosynthetic process
PVLB_RS18275	COG2996	Protein conserved in bacteria
PVLB_RS18285	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PVLB_RS18295	COG1116	anion transmembrane transporter activity
PVLB_RS18305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PVLB_RS18310	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS18325	COG1414	Transcriptional regulator
PVLB_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS18345	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS18390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PVLB_RS18400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PVLB_RS18410	COG1984	allophanate hydrolase subunit 2
PVLB_RS18415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PVLB_RS18420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PVLB_RS18425	COG2814	Major facilitator Superfamily
PVLB_RS18430	COG0583	DNA-binding transcription factor activity
PVLB_RS18440	COG0121	glutamine amidotransferase
PVLB_RS18480	COG2983	Belongs to the UPF0260 family
PVLB_RS18490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PVLB_RS18495	COG3100	YcgL domain-containing protein
PVLB_RS18505	COG2194	sulfuric ester hydrolase activity
PVLB_RS18520	COG0626	cystathionine gamma-synthase activity
PVLB_RS18525	COG1522	sequence-specific DNA binding
PVLB_RS18530	COG0243	molybdopterin cofactor binding
PVLB_RS18535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PVLB_RS18540	COG3781	membrane
PVLB_RS18545	COG0521	Mo-molybdopterin cofactor biosynthetic process
PVLB_RS18550	COG0583	DNA-binding transcription factor activity
PVLB_RS18560	COG0531	amino acid
PVLB_RS18565	COG3938	Belongs to the proline racemase family
PVLB_RS18570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PVLB_RS18580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS18585	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS18590	COG0640	Transcriptional regulator
PVLB_RS18595	COG0579	oxidoreductase
PVLB_RS18610	COG2271	Major facilitator Superfamily
PVLB_RS18615	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS18630	COG0129	dihydroxy-acid dehydratase activity
PVLB_RS18655	COG1477	protein flavinylation
PVLB_RS18680	COG0302	gtp cyclohydrolase
PVLB_RS18850	COG4626	Terminase
PVLB_RS18850	COG1802	Transcriptional regulator
PVLB_RS18900	COG0305	Participates in initiation and elongation during chromosome replication
PVLB_RS18905	COG1484	DNA-dependent DNA replication
PVLB_RS18960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PVLB_RS19005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PVLB_RS19010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PVLB_RS19015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PVLB_RS19020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PVLB_RS19030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PVLB_RS19040	COG0425	Belongs to the sulfur carrier protein TusA family
PVLB_RS19050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PVLB_RS19060	COG0531	amino acid
PVLB_RS19065	COG0840	transmembrane signaling receptor activity
PVLB_RS19085	COG3210	domain, Protein
PVLB_RS19110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PVLB_RS19120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PVLB_RS19125	COG0602	queuosine metabolic process
PVLB_RS19175	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PVLB_RS19180	COG2885	chlorophyll binding
PVLB_RS19185	COG0823	Involved in the tonB-independent uptake of proteins
PVLB_RS19205	COG0824	Thioesterase
PVLB_RS19210	COG2255	four-way junction helicase activity
PVLB_RS19215	COG0632	four-way junction helicase activity
PVLB_RS19220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PVLB_RS19225	COG0217	transcriptional regulatory protein
PVLB_RS19230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PVLB_RS19245	COG0783	Belongs to the Dps family
PVLB_RS19255	COG2900	Belongs to the SlyX family
PVLB_RS19270	COG0442	prolyl-tRNA aminoacylation
PVLB_RS19280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PVLB_RS19305	COG3158	transport of potassium into the cell
PVLB_RS19310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PVLB_RS19325	COG4807	Protein conserved in bacteria
PVLB_RS19340	COG0583	DNA-binding transcription factor activity
PVLB_RS19355	COG3148	PFAM DTW domain containing protein
PVLB_RS19375	COG2137	regulation of response to DNA damage stimulus
PVLB_RS19380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PVLB_RS19385	COG1546	Belongs to the CinA family
PVLB_RS19390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PVLB_RS19395	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PVLB_RS19410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PVLB_RS19415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PVLB_RS19420	COG0585	pseudouridine synthase activity
PVLB_RS19425	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PVLB_RS19435	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PVLB_RS19445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PVLB_RS19455	COG0148	phosphopyruvate hydratase activity
PVLB_RS19460	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PVLB_RS19465	COG0504	CTP synthase activity
PVLB_RS19470	COG0037	tRNA processing
PVLB_RS19475	COG0825	malonyl-CoA metabolic process
PVLB_RS19485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PVLB_RS19490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PVLB_RS19495	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PVLB_RS19500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PVLB_RS19505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PVLB_RS19515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PVLB_RS19525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PVLB_RS19535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PVLB_RS19540	COG0233	cytoplasmic translational termination
PVLB_RS19545	COG0528	UMP kinase activity
PVLB_RS19550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PVLB_RS19555	COG0052	Belongs to the universal ribosomal protein uS2 family
PVLB_RS19560	COG0024	Methionine aminopeptidase
PVLB_RS19565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PVLB_RS19570	COG0436	Aminotransferase
PVLB_RS19575	COG0025	NhaP-type Na H and K H
PVLB_RS19580	COG1393	Belongs to the ArsC family
PVLB_RS19585	COG2171	N-acyltransferase activity
PVLB_RS19590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PVLB_RS19600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PVLB_RS19605	COG1215	transferase activity, transferring glycosyl groups
PVLB_RS19610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PVLB_RS19615	COG2226	methyltransferase
PVLB_RS19630	COG2937	Belongs to the GPAT DAPAT family
PVLB_RS19650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PVLB_RS19665	COG0742	ribosomal rna small subunit methyltransferase
PVLB_RS19700	COG0563	adenylate kinase activity
PVLB_RS19705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PVLB_RS19720	COG2885	chlorophyll binding
PVLB_RS19720	COG3047	cAMP biosynthetic process
PVLB_RS19730	COG1073	alpha beta
PVLB_RS19750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PVLB_RS19765	COG4251	negative regulation of phosphorylation
PVLB_RS19765	COG3706	GGDEF domain
PVLB_RS19765	COG5001	Diguanylate cyclase
PVLB_RS19765	COG2203	Gaf domain
PVLB_RS19770	COG2201	protein-glutamate methylesterase activity
PVLB_RS19785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PVLB_RS19785	COG0457	Tetratricopeptide repeat
PVLB_RS19795	COG0840	transmembrane signaling receptor activity
PVLB_RS19800	COG2979	Protein of unknown function (DUF533)
PVLB_RS19805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PVLB_RS19810	COG3842	ATPase activity
PVLB_RS19815	COG1176	ABC-type spermidine putrescine transport system, permease component I
PVLB_RS19820	COG1177	transmembrane transport
PVLB_RS19825	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS19830	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS19845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PVLB_RS19880	COG4974	Belongs to the 'phage' integrase family
PVLB_RS19890	COG1607	acyl-coa hydrolase
PVLB_RS19895	COG0335	large ribosomal subunit rRNA binding
PVLB_RS19900	COG0336	Belongs to the RNA methyltransferase TrmD family
PVLB_RS19905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PVLB_RS19910	COG0228	four-way junction DNA binding
PVLB_RS19915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PVLB_RS19925	COG4536	flavin adenine dinucleotide binding
PVLB_RS19930	COG0477	Major facilitator Superfamily
PVLB_RS19935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PVLB_RS19965	COG3034	peptidoglycan biosynthetic process
PVLB_RS20010	COG2165	general secretion pathway protein
PVLB_RS20020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PVLB_RS20050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PVLB_RS20055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PVLB_RS20075	COG0047	phosphoribosylformylglycinamidine synthase activity
PVLB_RS20075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PVLB_RS20080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PVLB_RS20085	COG0590	tRNA wobble adenosine to inosine editing
PVLB_RS20095	COG0519	Catalyzes the synthesis of GMP from XMP
PVLB_RS20095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PVLB_RS20115	COG1570	exodeoxyribonuclease VII activity
PVLB_RS20120	COG0739	heme binding
PVLB_RS20125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PVLB_RS20130	COG0800	Aldolase
PVLB_RS20145	COG1737	Transcriptional regulator
PVLB_RS20150	COG0676	glucose-6-phosphate 1-epimerase activity
PVLB_RS20160	COG3842	ATPase activity
PVLB_RS20170	COG1175	transmembrane transport
PVLB_RS20175	COG1653	transport
PVLB_RS20225	COG2832	Protein of unknown function (DUF454)
PVLB_RS20240	COG2235	arginine
PVLB_RS20245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PVLB_RS20265	COG0509	glycine decarboxylation via glycine cleavage system
PVLB_RS20270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PVLB_RS20270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PVLB_RS20275	COG1760	l-serine dehydratase
PVLB_RS20280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PVLB_RS20285	COG1278	Cold shock
PVLB_RS20295	COG0795	lipopolysaccharide-transporting ATPase activity
PVLB_RS20300	COG0795	lipopolysaccharide-transporting ATPase activity
PVLB_RS20305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PVLB_RS20320	COG0525	valine-tRNA ligase activity
PVLB_RS20325	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PVLB_RS20330	COG0776	regulation of translation
PVLB_RS20335	COG3081	Nucleoid-associated protein
PVLB_RS20340	COG2827	Endonuclease containing a URI domain
PVLB_RS20350	COG2807	transmembrane transport
PVLB_RS20355	COG2186	Transcriptional regulator
PVLB_RS20365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PVLB_RS20370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PVLB_RS20375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PVLB_RS20380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PVLB_RS20400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PVLB_RS20405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PVLB_RS20410	COG1127	ABC transporter
PVLB_RS20420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PVLB_RS20430	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PVLB_RS20435	COG1137	ATPase activity
PVLB_RS20440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PVLB_RS20445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PVLB_RS20455	COG1660	Displays ATPase and GTPase activities
PVLB_RS20460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PVLB_RS20475	COG0312	modulator of DNA gyrase
PVLB_RS20480	COG3028	Belongs to the UPF0307 family
PVLB_RS20485	COG0312	modulator of DNA gyrase
PVLB_RS20490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PVLB_RS20505	COG0424	maF-like protein
PVLB_RS20510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PVLB_RS20515	COG1792	Involved in formation and maintenance of cell shape
PVLB_RS20520	COG1077	Cell shape determining protein MreB Mrl
PVLB_RS20525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PVLB_RS20530	COG0154	amidase activity
PVLB_RS20535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PVLB_RS20550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PVLB_RS20555	COG1113	amino acid transport
PVLB_RS20565	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PVLB_RS20580	COG0747	negative chemotaxis
PVLB_RS20585	COG0747	negative chemotaxis
PVLB_RS20595	COG0747	negative chemotaxis
PVLB_RS20600	COG0601	transmembrane transport
PVLB_RS20605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PVLB_RS20610	COG0444	Belongs to the ABC transporter superfamily
PVLB_RS20615	COG4608	Belongs to the ABC transporter superfamily
PVLB_RS20625	COG0723	plastoquinol--plastocyanin reductase activity
PVLB_RS20625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS20640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PVLB_RS20670	COG4772	TonB-dependent receptor
PVLB_RS20685	COG0019	diaminopimelate decarboxylase activity
PVLB_RS20700	COG3128	pkhd-type hydroxylase
PVLB_RS20705	COG4774	siderophore transport
PVLB_RS20715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PVLB_RS20720	COG0436	Aminotransferase
PVLB_RS20725	COG1160	GTP binding
PVLB_RS20740	COG0124	histidyl-tRNA synthetase
PVLB_RS20745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PVLB_RS20760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PVLB_RS20765	COG0105	UTP biosynthetic process
PVLB_RS20775	COG0633	Ferredoxin
PVLB_RS20780	COG0443	Heat shock 70 kDa protein
PVLB_RS20785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PVLB_RS20790	COG0316	Belongs to the HesB IscA family
PVLB_RS20800	COG1104	cysteine desulfurase activity
PVLB_RS20810	COG1045	serine acetyltransferase
PVLB_RS20825	COG3134	Outer membrane lipoprotein
PVLB_RS20840	COG1862	Preprotein translocase
PVLB_RS20845	COG0343	queuine tRNA-ribosyltransferase activity
PVLB_RS20850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PVLB_RS20860	COG0582	viral genome integration into host DNA
PVLB_RS20945	COG3781	membrane
PVLB_RS20950	COG3639	organic phosphonate transmembrane transporter activity
PVLB_RS20955	COG3639	organic phosphonate transmembrane transporter activity
PVLB_RS20960	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PVLB_RS20965	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PVLB_RS20970	COG0709	Synthesizes selenophosphate from selenide and ATP
PVLB_RS20975	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PVLB_RS20990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PVLB_RS20995	COG0727	PFAM Uncharacterised protein family (UPF0153)
PVLB_RS21000	COG0436	Aminotransferase
PVLB_RS21005	COG0109	protoheme IX farnesyltransferase activity
PVLB_RS21015	COG1845	cytochrome c oxidase, subunit III
PVLB_RS21020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PVLB_RS21025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PVLB_RS21030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PVLB_RS21035	COG1017	nitric oxide dioxygenase activity
PVLB_RS21035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PVLB_RS21040	COG3604	Transcriptional regulator
PVLB_RS21055	COG2274	protein secretion by the type I secretion system
PVLB_RS21100	COG3209	COG3209 Rhs family protein
PVLB_RS21110	COG3209	COG3209 Rhs family protein
PVLB_RS21140	COG3039	Transposase
PVLB_RS21180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PVLB_RS21205	COG4251	negative regulation of phosphorylation
PVLB_RS21205	COG2203	Gaf domain
PVLB_RS21205	COG3706	GGDEF domain
PVLB_RS21205	COG5001	Diguanylate cyclase
PVLB_RS21215	COG3530	Putative quorum-sensing-regulated virulence factor
PVLB_RS21220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PVLB_RS21220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PVLB_RS21220	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PVLB_RS21225	COG1105	Belongs to the carbohydrate kinase PfkB family
PVLB_RS21235	COG1609	Transcriptional regulator
PVLB_RS21240	COG0084	hydrolase, TatD family'
PVLB_RS21250	COG3725	Membrane protein required for beta-lactamase induction
PVLB_RS21255	COG3023	N-Acetylmuramoyl-L-alanine amidase
PVLB_RS21270	COG0492	ferredoxin-NADP+ reductase activity
PVLB_RS21275	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PVLB_RS21295	COG0386	Belongs to the glutathione peroxidase family
PVLB_RS21300	COG1047	Peptidyl-prolyl cis-trans
PVLB_RS21310	COG0857	belongs to the CobB CobQ family
PVLB_RS21310	COG0280	phosphate acetyltransferase
PVLB_RS21315	COG2885	chlorophyll binding
PVLB_RS21320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PVLB_RS21350	COG0318	PFAM AMP-dependent synthetase and ligase
PVLB_RS21355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PVLB_RS21360	COG2813	Specifically methylates the guanine in position
PVLB_RS21365	COG2119	membrane
PVLB_RS21370	COG0501	Belongs to the peptidase M48B family
PVLB_RS21375	COG2135	peptidase activity
PVLB_RS21405	COG0579	oxidoreductase
PVLB_RS21425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PVLB_RS21430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PVLB_RS21440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PVLB_RS21445	COG1090	epimerase
PVLB_RS21450	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PVLB_RS21455	COG3272	Protein of unknown function (DUF1722)
PVLB_RS21460	COG0789	Transcriptional regulator
PVLB_RS21480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PVLB_RS21485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PVLB_RS21495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PVLB_RS21500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PVLB_RS21510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PVLB_RS21515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PVLB_RS21525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PVLB_RS21530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PVLB_RS21535	COG0193	aminoacyl-tRNA hydrolase activity
PVLB_RS21560	COG1538	Outer membrane efflux protein
PVLB_RS21565	COG0628	permease
PVLB_RS21580	COG1335	isochorismatase
PVLB_RS21600	COG1511	domain protein
PVLB_RS21600	COG3264	Mechanosensitive ion channel
PVLB_RS21605	COG2169	Transcriptional regulator
PVLB_RS21605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PVLB_RS21615	COG1595	DNA-templated transcription, initiation
PVLB_RS21620	COG3712	iron ion homeostasis
PVLB_RS21635	COG2223	nitrite transmembrane transporter activity
PVLB_RS21670	COG0456	acetyltransferase
PVLB_RS21695	COG3045	CreA protein
PVLB_RS21700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PVLB_RS21705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PVLB_RS21710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PVLB_RS21715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PVLB_RS21720	COG0142	geranyltranstransferase activity
PVLB_RS21725	COG2824	Alkylphosphonate utilization operon protein PhnA
PVLB_RS21735	COG0545	Peptidyl-prolyl cis-trans isomerase
PVLB_RS21745	COG2862	Uncharacterized protein family, UPF0114
PVLB_RS21755	COG1067	ATP-dependent peptidase activity
PVLB_RS21775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PVLB_RS21780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PVLB_RS21785	COG0488	(ABC) transporter
PVLB_RS21800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PVLB_RS21820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS21825	COG0765	amino acid transport
PVLB_RS21830	COG0431	NADPH-dependent FMN reductase
PVLB_RS21840	COG0640	Transcriptional regulator
PVLB_RS21920	COG0582	viral genome integration into host DNA
PVLB_RS21945	COG0237	dephospho-CoA kinase activity
PVLB_RS21950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PVLB_RS21970	COG1252	NADH dehydrogenase
PVLB_RS21990	COG0542	response to heat
PVLB_RS22030	COG1172	Belongs to the binding-protein-dependent transport system permease family
PVLB_RS22055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS22085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PVLB_RS22090	COG1047	Peptidyl-prolyl cis-trans
PVLB_RS22095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PVLB_RS22100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PVLB_RS22105	COG0196	riboflavin kinase activity
PVLB_RS22115	COG0268	Binds directly to 16S ribosomal RNA
PVLB_RS22120	COG3008	intermembrane lipid transfer
PVLB_RS22125	COG2995	paraquat-inducible protein a
PVLB_RS22130	COG2995	paraquat-inducible protein a
PVLB_RS22175	COG1309	transcriptional regulator
PVLB_RS22180	COG1739	Uncharacterized protein family UPF0029
PVLB_RS22185	COG0300	oxidoreductase activity
PVLB_RS22195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PVLB_RS22205	COG2814	Major facilitator Superfamily
PVLB_RS22220	COG2217	Heavy metal translocating P-type atpase
PVLB_RS22230	COG0840	transmembrane signaling receptor activity
PVLB_RS22235	COG2207	Transcriptional regulator
PVLB_RS22245	COG1028	Short-chain dehydrogenase reductase Sdr
PVLB_RS22260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PVLB_RS22290	COG4953	penicillin-binding protein 1C
PVLB_RS22300	COG2373	Large extracellular alpha-helical protein
PVLB_RS22305	COG0534	Mate efflux family protein
PVLB_RS22310	COG1166	arginine decarboxylase activity
PVLB_RS22315	COG0023	Translation Initiation Factor
PVLB_RS22345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PVLB_RS22360	COG3284	Transcriptional regulator
PVLB_RS22365	COG3199	ATP-NAD kinase
PVLB_RS22370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PVLB_RS22375	COG0022	dehydrogenase e1 component
PVLB_RS22385	COG1063	alcohol dehydrogenase
PVLB_RS22390	COG1619	proteins homologs of microcin C7 resistance protein MccF
PVLB_RS22395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PVLB_RS22400	COG0321	lipoyl(octanoyl) transferase activity
PVLB_RS22405	COG2921	Belongs to the UPF0250 family
PVLB_RS22410	COG1686	Belongs to the peptidase S11 family
PVLB_RS22420	COG2951	lytic endotransglycosylase activity
PVLB_RS22425	COG0772	Belongs to the SEDS family
PVLB_RS22430	COG0768	penicillin binding
PVLB_RS22435	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PVLB_RS22445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PVLB_RS22450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PVLB_RS22455	COG2094	Belongs to the DNA glycosylase MPG family
PVLB_RS22460	COG0586	Pfam SNARE associated Golgi protein
PVLB_RS22470	COG1346	cytolysis
PVLB_RS22490	COG0702	epimerase
PVLB_RS22505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PVLB_RS22510	COG3284	Transcriptional regulator
PVLB_RS22520	COG0531	amino acid
PVLB_RS22525	COG4303	Ethanolamine ammonia lyase large subunit
PVLB_RS22530	COG4302	ethanolamine ammonia-lyase activity
PVLB_RS22535	COG0456	acetyltransferase
PVLB_RS22540	COG0586	Pfam SNARE associated Golgi protein
PVLB_RS22550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PVLB_RS22595	COG3039	Transposase
PVLB_RS22625	COG2132	Multicopper oxidase
PVLB_RS22645	COG1113	amino acid transport
PVLB_RS22660	COG0579	oxidoreductase
PVLB_RS22670	COG1802	Transcriptional regulator
PVLB_RS22675	COG1690	Belongs to the RtcB family
PVLB_RS22680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PVLB_RS22685	COG1722	exodeoxyribonuclease VII activity
PVLB_RS22690	COG0142	geranyltranstransferase activity
PVLB_RS22695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PVLB_RS22700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PVLB_RS22710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PVLB_RS22720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PVLB_RS22730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PVLB_RS22735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PVLB_RS22750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PVLB_RS22750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PVLB_RS22755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PVLB_RS22765	COG2264	protein methyltransferase activity
PVLB_RS22770	COG3118	belongs to the thioredoxin family
PVLB_RS22805	COG3047	cAMP biosynthetic process
PVLB_RS22810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PVLB_RS22825	COG1115	amino acid carrier protein
PVLB_RS22830	COG0252	asparaginase activity
PVLB_RS22840	COG3276	selenocysteine insertion sequence binding
PVLB_RS22845	COG1921	L-seryl-tRNASec selenium transferase activity
PVLB_RS22850	COG3058	Necessary for formate dehydrogenase activity
PVLB_RS22855	COG2864	formate dehydrogenase
PVLB_RS22860	COG0437	4 iron, 4 sulfur cluster binding
PVLB_RS22865	COG3383	formate dehydrogenase (NAD+) activity
PVLB_RS22865	COG0243	molybdopterin cofactor binding
PVLB_RS22870	COG3383	formate dehydrogenase (NAD+) activity
PVLB_RS22870	COG0243	molybdopterin cofactor binding
PVLB_RS22875	COG4221	oxidoreductase activity
PVLB_RS22890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PVLB_RS22895	COG0629	single-stranded DNA binding
PVLB_RS22900	COG2814	Major facilitator Superfamily
PVLB_RS22905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PVLB_RS22910	COG2193	ferroxidase activity
PVLB_RS22915	COG0753	catalase activity
PVLB_RS22920	COG0203	ribosomal protein L17
PVLB_RS22925	COG0202	RNA polymerase activity
PVLB_RS22930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PVLB_RS22935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PVLB_RS22940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PVLB_RS22945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PVLB_RS22955	COG0200	Binds to the 23S rRNA
PVLB_RS22960	COG1841	ribosomal large subunit assembly
PVLB_RS22965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PVLB_RS22970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PVLB_RS22975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PVLB_RS22980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PVLB_RS22985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PVLB_RS22990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PVLB_RS22995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PVLB_RS23000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PVLB_RS23005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PVLB_RS23010	COG0255	Belongs to the universal ribosomal protein uL29 family
PVLB_RS23015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PVLB_RS23020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PVLB_RS23025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PVLB_RS23030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PVLB_RS23035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PVLB_RS23040	COG0089	rRNA binding
PVLB_RS23045	COG0088	Forms part of the polypeptide exit tunnel
PVLB_RS23050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PVLB_RS23055	COG0051	transcription antitermination factor activity, RNA binding
PVLB_RS23060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PVLB_RS23065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PVLB_RS23070	COG0049	tRNA binding
PVLB_RS23075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PVLB_RS23080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PVLB_RS23085	COG0085	RNA polymerase activity
PVLB_RS23090	COG0222	ribosome binding
PVLB_RS23095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PVLB_RS23100	COG0081	regulation of translation
PVLB_RS23105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PVLB_RS23125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PVLB_RS23150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PVLB_RS23155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PVLB_RS23155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PVLB_RS23185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PVLB_RS23190	COG0739	heme binding
PVLB_RS23195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PVLB_RS23200	COG0316	Belongs to the HesB IscA family
PVLB_RS23205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PVLB_RS23210	COG1981	membrane
PVLB_RS23220	COG0300	oxidoreductase activity
PVLB_RS23225	COG0537	adenosine 5'-monophosphoramidase activity
PVLB_RS23230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PVLB_RS23240	COG1765	OsmC-like protein
PVLB_RS23255	COG0134	indole-3-glycerol-phosphate synthase activity
PVLB_RS23260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PVLB_RS23265	COG0512	Glutamine amidotransferase of anthranilate synthase
PVLB_RS23270	COG3240	lipase activity
PVLB_RS23270	COG4625	pathogenesis
PVLB_RS23275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PVLB_RS23280	COG0546	phosphoglycolate phosphatase activity
PVLB_RS23285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PVLB_RS23295	COG1176	ABC-type spermidine putrescine transport system, permease component I
PVLB_RS23305	COG3842	ATPase activity
PVLB_RS23310	COG2197	response regulator
PVLB_RS23315	COG4585	Histidine kinase
PVLB_RS23325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PVLB_RS23330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PVLB_RS23335	COG3178	'Phosphotransferase
PVLB_RS23340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PVLB_RS23345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PVLB_RS23350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PVLB_RS23355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PVLB_RS23360	COG2967	ApaG domain
PVLB_RS23365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PVLB_RS23370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PVLB_RS23375	COG2766	serine protein kinase
PVLB_RS23380	COG2718	Belongs to the UPF0229 family
PVLB_RS23385	COG2719	SpoVR family
PVLB_RS23390	COG0617	tRNA 3'-terminal CCA addition
PVLB_RS23400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PVLB_RS23405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PVLB_RS23410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PVLB_RS23415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PVLB_RS23420	COG0358	DNA primase activity
PVLB_RS23470	COG4993	Dehydrogenase
PVLB_RS23490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PVLB_RS23495	COG1025	Belongs to the peptidase M16 family
PVLB_RS23505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PVLB_RS23510	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PVLB_RS23520	COG0535	radical SAM domain protein
PVLB_RS23535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PVLB_RS23540	COG0583	DNA-binding transcription factor activity
PVLB_RS23545	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS23550	COG3706	GGDEF domain
PVLB_RS23555	COG1960	acyl-CoA dehydrogenase activity
PVLB_RS23580	COG0156	8-amino-7-oxononanoate synthase activity
PVLB_RS23585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PVLB_RS23590	COG1040	competence protein
PVLB_RS23595	COG3585	molybdate ion transport
PVLB_RS23595	COG2005	Transcriptional regulator
PVLB_RS23615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PVLB_RS23630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PVLB_RS23635	COG1595	DNA-templated transcription, initiation
PVLB_RS23640	COG3712	iron ion homeostasis
PVLB_RS23645	COG4774	siderophore transport
PVLB_RS23680	COG0438	transferase activity, transferring glycosyl groups
PVLB_RS23695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PVLB_RS23715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PVLB_RS23730	COG0204	Acyl-transferase
PVLB_RS23735	COG0531	amino acid
PVLB_RS23785	COG1063	alcohol dehydrogenase
PVLB_RS23815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PVLB_RS23830	COG0840	transmembrane signaling receptor activity
PVLB_RS23850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PVLB_RS23850	COG1017	nitric oxide dioxygenase activity
PVLB_RS23875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PVLB_RS23880	COG0247	lactate metabolic process
PVLB_RS23880	COG2181	nitrate reductase activity
PVLB_RS23885	COG1902	pentaerythritol trinitrate reductase activity
PVLB_RS23885	COG0446	pyridine nucleotide-disulphide oxidoreductase
PVLB_RS23915	COG3246	L-lysine catabolic process to acetate
PVLB_RS23920	COG1250	3-hydroxyacyl-CoA dehydrogenase
PVLB_RS23940	COG1760	l-serine dehydratase
PVLB_RS23950	COG4176	ABC-type proline glycine betaine transport system permease component
PVLB_RS23955	COG4175	Glycine betaine
PVLB_RS23960	COG0107	imidazoleglycerol-phosphate synthase activity
PVLB_RS23965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PVLB_RS23975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PVLB_RS23980	COG0131	Imidazoleglycerol-phosphate dehydratase
PVLB_RS23985	COG2223	nitrite transmembrane transporter activity
PVLB_RS24000	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PVLB_RS24035	COG4215	(ABC) transporter
PVLB_RS24285	COG0582	viral genome integration into host DNA
PVLB_RS24345	COG2026	Addiction module toxin, RelE StbE family
PVLB_RS24370	COG0069	glutamate synthase activity
PVLB_RS24380	COG2957	Belongs to the agmatine deiminase family
PVLB_RS24410	COG0494	nUDIX hydrolase
PVLB_RS24415	COG1011	Hydrolase
PVLB_RS24420	COG1652	LysM domain
PVLB_RS24425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PVLB_RS24430	COG0243	molybdopterin cofactor binding
PVLB_RS24445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PVLB_RS24450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PVLB_RS24460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PVLB_RS24465	COG0189	ligase activity
PVLB_RS24465	COG4067	protein conserved in archaea
PVLB_RS24470	COG0189	ligase activity
PVLB_RS24485	COG2183	response to ionizing radiation
PVLB_RS24495	COG2918	glutathione biosynthetic process
PVLB_RS24510	COG1116	anion transmembrane transporter activity
PVLB_RS24515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PVLB_RS24520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PVLB_RS24525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PVLB_RS24530	COG0431	NADPH-dependent FMN reductase
PVLB_RS24535	COG0450	alkyl hydroperoxide reductase
PVLB_RS24545	COG4521	taurine ABC transporter
PVLB_RS24550	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PVLB_RS24555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PVLB_RS24560	COG2175	clavaminate synthase activity
PVLB_RS24565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PVLB_RS24570	COG1045	serine acetyltransferase
PVLB_RS24575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PVLB_RS24580	COG0765	amino acid transport
PVLB_RS24585	COG1126	abc transporter atp-binding protein
PVLB_RS24590	COG3204	pilus organization
PVLB_RS24595	COG3204	pilus organization
PVLB_RS24600	COG0179	Fumarylacetoacetate (FAA) hydrolase
PVLB_RS24605	COG0277	FAD linked oxidase domain protein
PVLB_RS24610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PVLB_RS24670	COG3829	transcription factor binding
PVLB_RS24680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PVLB_RS24685	COG4208	sulfate ABC transporter
PVLB_RS24695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PVLB_RS24705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PVLB_RS24720	COG1177	transmembrane transport
PVLB_RS24725	COG1176	ABC-type spermidine putrescine transport system, permease component I
PVLB_RS24730	COG3842	ATPase activity
PVLB_RS24750	COG0174	glutamine synthetase
PVLB_RS24755	COG0174	glutamine synthetase
PVLB_RS24760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PVLB_RS24760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PVLB_RS24765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PVLB_RS24775	COG1522	sequence-specific DNA binding
PVLB_RS24795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PVLB_RS24795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PVLB_RS24800	COG0509	glycine decarboxylation via glycine cleavage system
PVLB_RS24805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PVLB_RS24810	COG1178	ABC-type Fe3 transport system permease component
PVLB_RS24820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PVLB_RS24830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PVLB_RS24835	COG0006	proline dipeptidase activity
PVLB_RS24840	COG3079	Belongs to the UPF0149 family
PVLB_RS24855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PVLB_RS24885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PVLB_RS24900	COG0248	Ppx GppA phosphatase
PVLB_RS24905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PVLB_RS24920	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PVLB_RS24925	COG1671	Belongs to the UPF0178 family
PVLB_RS24930	COG0672	)-iron permease
PVLB_RS24950	COG1289	transmembrane transporter activity
PVLB_RS24970	COG1335	isochorismatase
PVLB_RS24975	COG0583	DNA-binding transcription factor activity
PVLB_RS25000	COG1335	isochorismatase
PVLB_RS25020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS25025	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS25030	COG0583	DNA-binding transcription factor activity
PVLB_RS25035	COG5383	Protein conserved in bacteria
PVLB_RS25050	COG0534	Mate efflux family protein
PVLB_RS25065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PVLB_RS25070	COG0427	acetyl-CoA hydrolase
PVLB_RS25095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS25115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PVLB_RS25125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PVLB_RS25130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PVLB_RS25140	COG1012	belongs to the aldehyde dehydrogenase family
PVLB_RS25155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PVLB_RS25160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PVLB_RS25165	COG0747	negative chemotaxis
PVLB_RS25170	COG2003	Belongs to the UPF0758 family
PVLB_RS25175	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PVLB_RS25180	COG0756	dUTP diphosphatase activity
PVLB_RS25185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PVLB_RS25190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PVLB_RS25195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PVLB_RS25200	COG0708	Exodeoxyribonuclease III
PVLB_RS25205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PVLB_RS25210	COG1561	YicC-like family, N-terminal region
PVLB_RS25215	COG0194	GDP metabolic process
PVLB_RS25225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PVLB_RS25230	COG0174	glutamine synthetase
PVLB_RS25240	COG1758	RNA polymerase activity
PVLB_RS25245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PVLB_RS25270	COG0848	biopolymer transport protein
PVLB_RS25280	COG0583	DNA-binding transcription factor activity
PVLB_RS25285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PVLB_RS25315	COG3161	chorismate lyase activity
PVLB_RS25320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PVLB_RS25340	COG1253	flavin adenine dinucleotide binding
PVLB_RS25345	COG0739	heme binding
PVLB_RS25355	COG0704	Plays a role in the regulation of phosphate uptake
PVLB_RS25360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PVLB_RS25365	COG0581	inorganic phosphate transmembrane transporter activity
PVLB_RS25380	COG0477	Major facilitator Superfamily
PVLB_RS25385	COG1607	acyl-coa hydrolase
PVLB_RS25415	COG0583	DNA-binding transcription factor activity
PVLB_RS25420	COG1027	Aspartate ammonia-lyase
PVLB_RS25460	COG5016	pyruvate
PVLB_RS25460	COG0511	ligase activity, forming carbon-carbon bonds
PVLB_RS25465	COG0439	Biotin carboxylase
PVLB_RS25470	COG0583	DNA-binding transcription factor activity
PVLB_RS25480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PVLB_RS25485	COG3300	MHYT domain
PVLB_RS25485	COG5001	Diguanylate cyclase
PVLB_RS25490	COG0210	DNA helicase
PVLB_RS25505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PVLB_RS25505	COG4651	solute:proton antiporter activity
PVLB_RS25510	COG1607	acyl-coa hydrolase
PVLB_RS25515	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PVLB_RS25525	COG0523	cobalamin synthesis protein
PVLB_RS25545	COG1469	GTP cyclohydrolase I activity
PVLB_RS25555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PVLB_RS25560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PVLB_RS25565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PVLB_RS25570	COG1737	Transcriptional regulator
PVLB_RS25590	COG4215	(ABC) transporter
PVLB_RS25625	COG3209	COG3209 Rhs family protein
PVLB_RS25650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PVLB_RS25655	COG0501	Belongs to the peptidase M48B family
PVLB_RS25710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PVLB_RS25720	COG0542	response to heat
PVLB_RS25725	COG0071	Belongs to the small heat shock protein (HSP20) family
PVLB_RS25770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PVLB_RS25775	COG1349	DNA-binding transcription factor activity
PVLB_RS25780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PVLB_RS25785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PVLB_RS25790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PVLB_RS25795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PVLB_RS25800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PVLB_RS25805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PVLB_RS25810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PVLB_RS25820	COG0356	it plays a direct role in the translocation of protons across the membrane
PVLB_RS25825	COG3312	ion transport
PVLB_RS25830	COG1475	DNA binding
PVLB_RS25835	COG1192	Involved in chromosome partitioning
PVLB_RS25840	COG0357	Ribosomal RNA small subunit methyltransferase G
PVLB_RS25845	COG0445	tRNA wobble uridine modification
PVLB_RS25850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PVLB_RS25855	COG0706	membrane insertase activity
PVLB_RS25860	COG0594	ribonuclease P activity
PVLB_RS25865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PVLB_RS26055	COG5002	protein histidine kinase activity
PVLB_RS26220	COG2843	Capsule synthesis protein
PVLB_RS26325	COG0569	domain protein
PVLB_RS26330	COG0569	domain protein
PVLB_RS26510	COG2011	ABC-type metal ion transport system permease component
PVLB_RS26685	COG0700	Nucleoside recognition
PVLB_RS26750	COG1283	sodium-dependent phosphate transmembrane transporter activity
PVLB_RS27250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PVLB_RS27275	COG0457	Tetratricopeptide repeat
PVLB_RS27275	COG3118	belongs to the thioredoxin family
PVLB_RS27705	COG0456	acetyltransferase
PVLB_RS27745	COG3706	GGDEF domain
PVLB_RS27760	COG3646	Phage regulatory protein