locus-tag	class	description
HG264_RS00070	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HG264_RS00075	COG0463	Glycosyl transferase, family 2
HG264_RS00105	COG1368	sulfuric ester hydrolase activity
HG264_RS00115	COG0642	Histidine kinase
HG264_RS00125	COG3642	lipopolysaccharide core region biosynthetic process
HG264_RS00135	COG1368	sulfuric ester hydrolase activity
HG264_RS00150	COG0668	transmembrane transport
HG264_RS00160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HG264_RS00170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG264_RS00175	COG1335	isochorismatase
HG264_RS00195	COG1802	Transcriptional regulator
HG264_RS00205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG264_RS00215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG264_RS00220	COG0697	spore germination
HG264_RS00255	COG0154	amidase activity
HG264_RS00265	COG0583	DNA-binding transcription factor activity
HG264_RS00275	COG2207	Transcriptional regulator
HG264_RS00290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG264_RS00300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG264_RS00315	COG0596	Alpha beta hydrolase
HG264_RS00340	COG0402	S-adenosylhomocysteine deaminase activity
HG264_RS00345	COG1309	transcriptional regulator
HG264_RS00365	COG1129	ABC transporter
HG264_RS00375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG264_RS00390	COG2351	hydroxyisourate hydrolase activity
HG264_RS00395	COG0402	S-adenosylhomocysteine deaminase activity
HG264_RS00405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG264_RS00415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG264_RS00435	COG2271	Major facilitator Superfamily
HG264_RS00440	COG0583	DNA-binding transcription factor activity
HG264_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS00495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG264_RS00500	COG0642	Histidine kinase
HG264_RS00515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG264_RS00530	COG1999	signal sequence binding
HG264_RS00540	COG2321	neutral zinc metallopeptidase
HG264_RS00555	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS00570	COG2356	endonuclease I
HG264_RS00575	COG1024	Enoyl-CoA hydratase
HG264_RS00575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG264_RS00580	COG3547	Transposase (IS116 IS110 IS902 family)
HG264_RS00590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG264_RS00595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG264_RS00605	COG0628	permease
HG264_RS00625	COG1393	Belongs to the ArsC family
HG264_RS00630	COG1295	ribonuclease BN
HG264_RS00635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG264_RS00640	COG1254	Belongs to the acylphosphatase family
HG264_RS00665	COG2900	Belongs to the SlyX family
HG264_RS00670	COG1278	Cold shock
HG264_RS00675	COG0783	Belongs to the Dps family
HG264_RS00680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG264_RS00690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG264_RS00695	COG0632	four-way junction helicase activity
HG264_RS00700	COG2255	four-way junction helicase activity
HG264_RS00705	COG0824	Thioesterase
HG264_RS00725	COG0823	Involved in the tonB-independent uptake of proteins
HG264_RS00730	COG2885	chlorophyll binding
HG264_RS00735	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HG264_RS00740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG264_RS00765	COG3685	Protein conserved in bacteria
HG264_RS00805	COG0425	Belongs to the sulfur carrier protein TusA family
HG264_RS00815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG264_RS00820	COG2716	regulation of RNA biosynthetic process
HG264_RS00825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG264_RS00835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG264_RS00840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG264_RS00945	COG0789	Transcriptional regulator
HG264_RS00970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG264_RS01010	COG2132	Multicopper oxidase
HG264_RS01090	COG0582	viral genome integration into host DNA
HG264_RS01125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG264_RS01130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG264_RS01175	COG2755	lipolytic protein G-D-S-L family
HG264_RS01175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG264_RS01185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG264_RS01190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG264_RS01195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG264_RS01245	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HG264_RS01275	COG0545	Peptidyl-prolyl cis-trans isomerase
HG264_RS01285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG264_RS01285	COG3321	synthase
HG264_RS01285	COG4221	oxidoreductase activity
HG264_RS01285	COG0604	alcohol dehydrogenase
HG264_RS01290	COG1362	aminopeptidase activity
HG264_RS01295	COG0564	pseudouridine synthase activity
HG264_RS01300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HG264_RS01305	COG2894	cell division
HG264_RS01310	COG0850	regulation of cytokinetic process
HG264_RS01315	COG1560	Kdo2-lipid A biosynthetic process
HG264_RS01360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG264_RS01375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG264_RS01380	COG0527	aspartate kinase activity
HG264_RS01385	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG264_RS01400	COG2239	Acts as a magnesium transporter
HG264_RS01405	COG3630	sodium ion export across plasma membrane
HG264_RS01410	COG5016	pyruvate
HG264_RS01410	COG0511	ligase activity, forming carbon-carbon bonds
HG264_RS01415	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HG264_RS01430	COG1414	Transcriptional regulator
HG264_RS01460	COG4948	Mandelate Racemase Muconate Lactonizing
HG264_RS01465	COG4829	muconolactone delta-isomerase
HG264_RS01470	COG3485	protocatechuate 3,4-dioxygenase
HG264_RS01475	COG3135	benzoate transporter
HG264_RS01480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG264_RS01485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HG264_RS01490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG264_RS01500	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HG264_RS01520	COG0784	Response regulator, receiver
HG264_RS01520	COG0835	chemotaxis
HG264_RS01525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HG264_RS01530	COG1815	bacterial-type flagellum-dependent cell motility
HG264_RS01540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG264_RS01550	COG4787	bacterial-type flagellum-dependent cell motility
HG264_RS01555	COG4786	Flagellar basal body rod
HG264_RS01565	COG1706	bacterial-type flagellum-dependent cell motility
HG264_RS01575	COG1256	bacterial-type flagellum assembly
HG264_RS01590	COG2217	Heavy metal translocating P-type atpase
HG264_RS01595	COG3608	succinylglutamate desuccinylase aspartoacylase
HG264_RS01595	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HG264_RS01605	COG2080	2 iron, 2 sulfur cluster binding
HG264_RS01610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HG264_RS01615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HG264_RS01625	COG0500	methyltransferase
HG264_RS01635	COG5002	protein histidine kinase activity
HG264_RS01640	COG2204	response regulator
HG264_RS01655	COG0438	transferase activity, transferring glycosyl groups
HG264_RS01680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HG264_RS01685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HG264_RS01705	COG1902	pentaerythritol trinitrate reductase activity
HG264_RS01710	COG0640	Transcriptional regulator
HG264_RS01715	COG0477	Major facilitator Superfamily
HG264_RS01720	COG0753	catalase activity
HG264_RS01735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG264_RS01745	COG3089	Belongs to the UPF0270 family
HG264_RS01755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG264_RS01755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HG264_RS01760	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG264_RS01765	COG0697	spore germination
HG264_RS01780	COG0271	Belongs to the BolA IbaG family
HG264_RS01815	COG0514	ATP-dependent DNA helicase (RecQ)
HG264_RS01820	COG1752	Esterase of the alpha-beta hydrolase superfamily
HG264_RS01860	COG0745	RESPONSE REGULATOR receiver
HG264_RS01870	COG2350	Protein conserved in bacteria
HG264_RS01875	COG0613	PHP domain protein
HG264_RS01880	COG0009	L-threonylcarbamoyladenylate synthase
HG264_RS01885	COG0180	Tryptophanyl-tRNA synthetase
HG264_RS01895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG264_RS01905	COG3706	GGDEF domain
HG264_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS01925	COG0402	S-adenosylhomocysteine deaminase activity
HG264_RS01930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG264_RS01940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG264_RS01950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG264_RS01955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG264_RS01960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HG264_RS01970	COG0776	regulation of translation
HG264_RS01980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HG264_RS01985	COG0284	orotidine-5'-phosphate decarboxylase activity
HG264_RS02005	COG2211	Major facilitator Superfamily
HG264_RS02030	COG3842	ATPase activity
HG264_RS02040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG264_RS02045	COG0303	'Molybdopterin
HG264_RS02050	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG264_RS02055	COG0746	molybdenum cofactor guanylyltransferase activity
HG264_RS02075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG264_RS02080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HG264_RS02090	COG2130	NADP-dependent
HG264_RS02105	COG2197	response regulator
HG264_RS02120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG264_RS02125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG264_RS02140	COG2217	Heavy metal translocating P-type atpase
HG264_RS02155	COG2010	Cytochrome c
HG264_RS02170	COG3278	Belongs to the heme-copper respiratory oxidase family
HG264_RS02185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HG264_RS02190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HG264_RS02195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HG264_RS02200	COG0489	protein tyrosine kinase activity
HG264_RS02205	COG0717	Belongs to the dCTP deaminase family
HG264_RS02235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG264_RS02280	COG1611	Belongs to the LOG family
HG264_RS02285	COG2072	flavoprotein involved in K transport
HG264_RS02290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG264_RS02310	COG0530	calcium, potassium:sodium antiporter activity
HG264_RS02320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HG264_RS02335	COG2860	membrane
HG264_RS02355	COG3501	Rhs element vgr protein
HG264_RS02370	COG0826	peptidase U32
HG264_RS02390	COG2267	carboxylic ester hydrolase activity
HG264_RS02395	COG1024	Enoyl-CoA hydratase
HG264_RS02415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HG264_RS02435	COG1944	ATP diphosphatase activity
HG264_RS02440	COG0433	COG0433 Predicted ATPase
HG264_RS02470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HG264_RS02490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG264_RS02520	COG1278	Cold shock
HG264_RS02525	COG0493	'glutamate synthase
HG264_RS02535	COG0745	RESPONSE REGULATOR receiver
HG264_RS02540	COG2205	protein histidine kinase activity
HG264_RS02565	COG0583	DNA-binding transcription factor activity
HG264_RS02570	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HG264_RS02595	COG3101	peptidyl-lysine hydroxylation
HG264_RS02600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG264_RS02625	COG0436	Aminotransferase
HG264_RS02630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG264_RS02635	COG0386	Belongs to the glutathione peroxidase family
HG264_RS02640	COG5002	protein histidine kinase activity
HG264_RS02640	COG2205	protein histidine kinase activity
HG264_RS02640	COG0784	Response regulator, receiver
HG264_RS02650	COG0625	glutathione transferase activity
HG264_RS02680	COG1131	(ABC) transporter
HG264_RS02685	COG0842	Transport permease protein
HG264_RS02690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG264_RS02690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG264_RS02700	COG2853	Lipoprotein
HG264_RS02705	COG4566	intracellular signal transduction
HG264_RS02715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG264_RS02720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG264_RS02815	COG3501	Rhs element vgr protein
HG264_RS02820	COG2204	response regulator
HG264_RS02875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG264_RS02880	COG0583	DNA-binding transcription factor activity
HG264_RS02885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG264_RS02910	COG1982	Orn Lys Arg decarboxylase major
HG264_RS02920	COG3123	guanosine phosphorylase activity
HG264_RS02930	COG2084	Dehydrogenase
HG264_RS02945	COG2009	succinate dehydrogenase
HG264_RS02950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HG264_RS02955	COG1053	succinate dehydrogenase
HG264_RS02980	COG0045	succinate-CoA ligase (ADP-forming) activity
HG264_RS03020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG264_RS03030	COG0243	molybdopterin cofactor binding
HG264_RS03035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG264_RS03040	COG2223	nitrite transmembrane transporter activity
HG264_RS03095	COG4770	biotin carboxylase activity
HG264_RS03145	COG1132	(ABC) transporter
HG264_RS03155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HG264_RS03160	COG3091	SprT-like family
HG264_RS03185	COG0037	tRNA processing
HG264_RS03195	COG0791	NLP P60 protein
HG264_RS03220	COG2056	Na+-H+ antiporter family
HG264_RS03225	COG0137	argininosuccinate synthase activity
HG264_RS03250	COG2983	Belongs to the UPF0260 family
HG264_RS03255	COG2853	Lipoprotein
HG264_RS03275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG264_RS03280	COG4660	Part of a membrane complex involved in electron transport
HG264_RS03285	COG4659	FMN binding
HG264_RS03290	COG4658	electron transport chain
HG264_RS03300	COG2878	Part of a membrane complex involved in electron transport
HG264_RS03305	COG4657	Part of a membrane complex involved in electron transport
HG264_RS03310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG264_RS03310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG264_RS03360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG264_RS03390	COG1794	racemase activity, acting on amino acids and derivatives
HG264_RS03405	COG0784	Response regulator, receiver
HG264_RS03405	COG0835	chemotaxis
HG264_RS03420	COG0513	Belongs to the DEAD box helicase family
HG264_RS03430	COG3171	Protein conserved in bacteria
HG264_RS03435	COG1704	LemA family
HG264_RS03440	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HG264_RS03465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HG264_RS03495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HG264_RS03520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG264_RS03545	COG5507	3-demethylubiquinone-9 3-methyltransferase
HG264_RS03550	COG3795	YCII-related domain
HG264_RS03555	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HG264_RS03560	COG4941	Belongs to the sigma-70 factor family
HG264_RS03565	COG0436	Aminotransferase
HG264_RS03585	COG0473	3-isopropylmalate dehydrogenase activity
HG264_RS03595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HG264_RS03615	COG2814	Major facilitator Superfamily
HG264_RS03620	COG1921	L-seryl-tRNASec selenium transferase activity
HG264_RS03630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG264_RS03635	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS03640	COG0784	Response regulator, receiver
HG264_RS03640	COG2205	protein histidine kinase activity
HG264_RS03640	COG5002	protein histidine kinase activity
HG264_RS03655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG264_RS03665	COG2062	phosphohistidine phosphatase, SixA
HG264_RS03695	COG0709	Synthesizes selenophosphate from selenide and ATP
HG264_RS03700	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HG264_RS03725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG264_RS03735	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HG264_RS03755	COG0583	DNA-binding transcription factor activity
HG264_RS03760	COG3134	Outer membrane lipoprotein
HG264_RS03775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG264_RS03780	COG0066	3-isopropylmalate dehydratase activity
HG264_RS03785	COG2226	methyltransferase
HG264_RS03800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG264_RS03815	COG0135	phosphoribosylanthranilate isomerase activity
HG264_RS03820	COG0133	tryptophan synthase activity
HG264_RS03825	COG0159	tryptophan synthase activity
HG264_RS03835	COG0285	dihydrofolate synthase activity
HG264_RS03845	COG1286	toxin biosynthetic process
HG264_RS03860	COG1555	photosystem II stabilization
HG264_RS03860	COG1596	polysaccharide export
HG264_RS03875	COG3100	YcgL domain-containing protein
HG264_RS03885	COG3530	Putative quorum-sensing-regulated virulence factor
HG264_RS03890	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS03900	COG3106	COG3106 Predicted ATPase
HG264_RS03905	COG3768	UPF0283 membrane protein
HG264_RS03920	COG0500	methyltransferase
HG264_RS03925	COG2226	methyltransferase
HG264_RS03935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG264_RS03940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG264_RS03945	COG1770	oligopeptidase
HG264_RS03960	COG1278	Cold shock
HG264_RS03965	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HG264_RS03970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG264_RS03980	COG0542	response to heat
HG264_RS03990	COG3128	pkhd-type hydroxylase
HG264_RS04000	COG4774	siderophore transport
HG264_RS04010	COG0848	biopolymer transport protein
HG264_RS04025	COG2030	dehydratase
HG264_RS04030	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS04040	COG1643	Atp-dependent helicase
HG264_RS04075	COG0583	DNA-binding transcription factor activity
HG264_RS04095	COG0556	nucleotide-excision repair
HG264_RS04175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HG264_RS04245	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HG264_RS04265	COG3772	lysozyme
HG264_RS04280	COG4220	transposase activity
HG264_RS04300	COG0740	serine-type endopeptidase activity
HG264_RS04340	COG3941	tape measure
HG264_RS04375	COG2226	methyltransferase
HG264_RS04390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG264_RS04415	COG0072	phenylalanine-tRNA ligase activity
HG264_RS04420	COG0776	regulation of translation
HG264_RS04435	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HG264_RS04445	COG2755	lipolytic protein G-D-S-L family
HG264_RS04445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG264_RS04460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HG264_RS04510	COG3243	poly(R)-hydroxyalkanoic acid synthase
HG264_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS04555	COG2723	6-phospho-beta-galactosidase activity
HG264_RS04560	COG1132	(ABC) transporter
HG264_RS04595	COG1064	alcohol dehydrogenase
HG264_RS04600	COG0420	3'-5' exonuclease activity
HG264_RS04620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG264_RS04640	COG0076	glutamate decarboxylase activity
HG264_RS04670	COG2223	nitrite transmembrane transporter activity
HG264_RS04675	COG2067	long-chain fatty acid transport protein
HG264_RS04740	COG0826	peptidase U32
HG264_RS04745	COG0826	peptidase U32
HG264_RS04750	COG3154	lipid carrier protein
HG264_RS04760	COG2197	response regulator
HG264_RS04765	COG3850	Histidine kinase
HG264_RS04790	COG2010	Cytochrome c
HG264_RS04795	COG0714	Associated with various cellular activities
HG264_RS04800	COG3901	Regulator of nitric oxide reductase transcription
HG264_RS04800	COG0348	domain, Protein
HG264_RS04805	COG4263	nitrous-oxide reductase activity
HG264_RS04820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HG264_RS04835	COG2832	Protein of unknown function (DUF454)
HG264_RS04840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG264_RS04850	COG0714	Associated with various cellular activities
HG264_RS04855	COG3256	nitric oxide reductase
HG264_RS04860	COG2010	Cytochrome c
HG264_RS04880	COG3604	Transcriptional regulator
HG264_RS04885	COG3278	Belongs to the heme-copper respiratory oxidase family
HG264_RS04890	COG0517	IMP dehydrogenase activity
HG264_RS04890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG264_RS04890	COG0617	tRNA 3'-terminal CCA addition
HG264_RS04895	COG0583	DNA-binding transcription factor activity
HG264_RS04905	COG1295	ribonuclease BN
HG264_RS04945	COG3360	Dodecin
HG264_RS04950	COG0517	IMP dehydrogenase activity
HG264_RS04955	COG0676	glucose-6-phosphate 1-epimerase activity
HG264_RS04985	COG2911	Protein conserved in bacteria
HG264_RS04990	COG0729	surface antigen
HG264_RS04995	COG0708	Exodeoxyribonuclease III
HG264_RS05000	COG0542	response to heat
HG264_RS05005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG264_RS05010	COG1278	Cold shock
HG264_RS05025	COG0482	sulfurtransferase activity
HG264_RS05030	COG2915	High frequency lysogenization protein hflD homolog
HG264_RS05045	COG2850	peptidyl-arginine hydroxylation
HG264_RS05080	COG0668	transmembrane transport
HG264_RS05105	COG0583	DNA-binding transcription factor activity
HG264_RS05110	COG4771	TonB-dependent receptor
HG264_RS05135	COG2166	iron-sulfur cluster assembly
HG264_RS05150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG264_RS05155	COG0719	Fe-S assembly protein
HG264_RS05160	COG0396	ATPase activity
HG264_RS05165	COG0719	Fe-S assembly protein
HG264_RS05185	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HG264_RS05205	COG1115	amino acid carrier protein
HG264_RS05210	COG0215	cysteine-tRNA ligase activity
HG264_RS05215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG264_RS05220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG264_RS05225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG264_RS05245	COG0727	PFAM Uncharacterised protein family (UPF0153)
HG264_RS05275	COG0519	Catalyzes the synthesis of GMP from XMP
HG264_RS05275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG264_RS05290	COG0628	permease
HG264_RS05305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG264_RS05310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG264_RS05320	COG3058	Necessary for formate dehydrogenase activity
HG264_RS05325	COG2864	formate dehydrogenase
HG264_RS05330	COG0437	4 iron, 4 sulfur cluster binding
HG264_RS05345	COG3276	selenocysteine insertion sequence binding
HG264_RS05375	COG5654	RES domain protein
HG264_RS05390	COG0789	Transcriptional regulator
HG264_RS05395	COG2202	Pas domain
HG264_RS05395	COG1366	Belongs to the anti-sigma-factor antagonist family
HG264_RS05405	COG3706	GGDEF domain
HG264_RS05405	COG5001	Diguanylate cyclase
HG264_RS05405	COG4251	negative regulation of phosphorylation
HG264_RS05405	COG2203	Gaf domain
HG264_RS05415	COG0789	Transcriptional regulator
HG264_RS05425	COG2135	peptidase activity
HG264_RS05430	COG4191	Histidine kinase
HG264_RS05430	COG0784	Response regulator, receiver
HG264_RS05435	COG2205	protein histidine kinase activity
HG264_RS05445	COG2172	sigma factor antagonist activity
HG264_RS05450	COG1366	Belongs to the anti-sigma-factor antagonist family
HG264_RS05455	COG1366	Belongs to the anti-sigma-factor antagonist family
HG264_RS05485	COG1739	Uncharacterized protein family UPF0029
HG264_RS05500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG264_RS05540	COG0210	DNA helicase
HG264_RS05555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG264_RS05595	COG2920	part of a sulfur-relay system
HG264_RS05605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG264_RS05620	COG0848	biopolymer transport protein
HG264_RS05625	COG0811	peptide transport
HG264_RS05640	COG3265	gluconokinase activity
HG264_RS05655	COG0003	Pfam Anion-transporting ATPase
HG264_RS05665	COG1966	Carbon starvation protein
HG264_RS05670	COG3040	lipid binding
HG264_RS05675	COG0519	Catalyzes the synthesis of GMP from XMP
HG264_RS05680	COG0598	Magnesium transport protein CorA
HG264_RS05690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG264_RS05695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG264_RS05700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG264_RS05705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HG264_RS05715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HG264_RS05720	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HG264_RS05725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG264_RS05745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG264_RS05825	COG2824	Alkylphosphonate utilization operon protein PhnA
HG264_RS05830	COG0217	transcriptional regulatory protein
HG264_RS05850	COG0714	Associated with various cellular activities
HG264_RS05865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG264_RS05870	COG1322	Protein conserved in bacteria
HG264_RS05900	COG2272	Belongs to the type-B carboxylesterase lipase family
HG264_RS05915	COG0084	hydrolase, TatD family'
HG264_RS05930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG264_RS05935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HG264_RS05940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG264_RS05945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG264_RS05950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG264_RS05965	COG0416	fatty acid biosynthetic process
HG264_RS05970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HG264_RS05975	COG1399	metal-binding, possibly nucleic acid-binding protein
HG264_RS05980	COG0424	maF-like protein
HG264_RS05985	COG0616	signal peptide processing
HG264_RS05985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HG264_RS05990	COG0546	phosphoglycolate phosphatase activity
HG264_RS06000	COG1530	ribonuclease E activity
HG264_RS06005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG264_RS06010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG264_RS06015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HG264_RS06020	COG2835	tetraacyldisaccharide 4'-kinase activity
HG264_RS06025	COG1663	tetraacyldisaccharide 4'-kinase activity
HG264_RS06030	COG0848	biopolymer transport protein
HG264_RS06035	COG0811	peptide transport
HG264_RS06040	COG2333	competence protein COMEC
HG264_RS06040	COG0658	competence protein
HG264_RS06055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG264_RS06065	COG3949	Membrane
HG264_RS06090	COG0584	glycerophosphoryl diester phosphodiesterase
HG264_RS06095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG264_RS06115	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HG264_RS06130	COG1805	sodium ion transport
HG264_RS06145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG264_RS06210	COG1024	Enoyl-CoA hydratase
HG264_RS06210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG264_RS06215	COG0589	response to stress
HG264_RS06230	COG0784	Response regulator, receiver
HG264_RS06230	COG0835	chemotaxis
HG264_RS06235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HG264_RS06235	COG0316	Belongs to the HesB IscA family
HG264_RS06255	COG0534	Mate efflux family protein
HG264_RS06265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG264_RS06275	COG0604	alcohol dehydrogenase
HG264_RS06280	COG0616	signal peptide processing
HG264_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS06305	COG2816	NAD+ diphosphatase activity
HG264_RS06315	COG1024	Enoyl-CoA hydratase
HG264_RS06325	COG0328	RNA-DNA hybrid ribonuclease activity
HG264_RS06335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG264_RS06340	COG1388	LysM domain
HG264_RS06340	COG0741	lytic transglycosylase activity
HG264_RS06350	COG4166	transmembrane transport
HG264_RS06355	COG4174	ABC transporter (Permease)
HG264_RS06360	COG4239	(ABC) transporter, permease
HG264_RS06365	COG4172	Belongs to the ABC transporter superfamily
HG264_RS06375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG264_RS06385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG264_RS06390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG264_RS06400	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG264_RS06430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG264_RS06455	COG1802	Transcriptional regulator
HG264_RS06465	COG0189	ligase activity
HG264_RS06475	COG0560	Phosphoserine phosphatase
HG264_RS06495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HG264_RS06510	COG2610	gluconate transmembrane transporter activity
HG264_RS06520	COG1376	ErfK ybiS ycfS ynhG family protein
HG264_RS06535	COG4181	ATPase activity
HG264_RS06540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HG264_RS06550	COG0435	Glutathione S-transferase
HG264_RS06560	COG0084	hydrolase, TatD family'
HG264_RS06570	COG0116	Belongs to the methyltransferase superfamily
HG264_RS06570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HG264_RS06575	COG3130	regulation of translation
HG264_RS06580	COG0167	dihydroorotate dehydrogenase activity
HG264_RS06595	COG0714	Associated with various cellular activities
HG264_RS06610	COG2304	oxidoreductase activity
HG264_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS06640	COG0308	aminopeptidase N
HG264_RS06650	COG3139	Protein of unknown function (DUF1315)
HG264_RS06655	COG0705	Rhomboid family
HG264_RS06660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG264_RS06680	COG1902	pentaerythritol trinitrate reductase activity
HG264_RS06680	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG264_RS06700	COG3383	formate dehydrogenase (NAD+) activity
HG264_RS06735	COG2989	Protein conserved in bacteria
HG264_RS06745	COG2072	flavoprotein involved in K transport
HG264_RS06760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG264_RS06765	COG2814	Major facilitator Superfamily
HG264_RS06770	COG1960	acyl-CoA dehydrogenase activity
HG264_RS06785	COG3048	D-serine ammonia-lyase activity
HG264_RS06795	COG3122	Protein conserved in bacteria
HG264_RS06800	COG4067	protein conserved in archaea
HG264_RS06800	COG0189	ligase activity
HG264_RS06805	COG0840	transmembrane signaling receptor activity
HG264_RS06815	COG0418	dihydroorotase activity
HG264_RS06820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HG264_RS06825	COG2358	TRAP transporter, solute receptor (TAXI family
HG264_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS06855	COG5265	(ABC) transporter
HG264_RS06860	COG0659	secondary active sulfate transmembrane transporter activity
HG264_RS06865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG264_RS06880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HG264_RS06885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HG264_RS06900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG264_RS06905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG264_RS06920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HG264_RS06930	COG0463	Glycosyl transferase, family 2
HG264_RS06960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG264_RS06985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HG264_RS07025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG264_RS07035	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HG264_RS07045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG264_RS07050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG264_RS07080	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG264_RS07095	COG0513	Belongs to the DEAD box helicase family
HG264_RS07145	COG1960	acyl-CoA dehydrogenase activity
HG264_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS07160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG264_RS07170	COG2169	Transcriptional regulator
HG264_RS07170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HG264_RS07175	COG3145	DNA-N1-methyladenine dioxygenase activity
HG264_RS07180	COG1960	acyl-CoA dehydrogenase activity
HG264_RS07185	COG0183	Belongs to the thiolase family
HG264_RS07210	COG3115	cell septum assembly
HG264_RS07225	COG0471	metal ion transport
HG264_RS07250	COG1138	Cytochrome C-type biogenesis protein
HG264_RS07285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG264_RS07295	COG0835	chemotaxis
HG264_RS07305	COG1192	Involved in chromosome partitioning
HG264_RS07315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG264_RS07325	COG0643	Histidine kinase
HG264_RS07325	COG2198	Histidine kinase
HG264_RS07325	COG0784	Response regulator, receiver
HG264_RS07330	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HG264_RS07355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG264_RS07365	COG2200	EAL domain
HG264_RS07365	COG3287	FIST C domain
HG264_RS07365	COG2199	diguanylate cyclase activity
HG264_RS07370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG264_RS07375	COG2124	cytochrome p450
HG264_RS07405	COG3604	Transcriptional regulator
HG264_RS07415	COG1846	Transcriptional regulator
HG264_RS07420	COG1960	acyl-CoA dehydrogenase activity
HG264_RS07425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HG264_RS07435	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS07440	COG1024	Enoyl-CoA hydratase
HG264_RS07465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HG264_RS07485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HG264_RS07510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG264_RS07530	COG0517	IMP dehydrogenase activity
HG264_RS07530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG264_RS07530	COG0617	tRNA 3'-terminal CCA addition
HG264_RS07545	COG2925	Exonuclease
HG264_RS07560	COG0589	response to stress
HG264_RS07585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HG264_RS07585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HG264_RS07590	COG3706	GGDEF domain
HG264_RS07600	COG1024	Enoyl-CoA hydratase
HG264_RS07630	COG0583	DNA-binding transcription factor activity
HG264_RS07635	COG1279	arginine transmembrane transporter activity
HG264_RS07650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG264_RS07650	COG0723	plastoquinol--plastocyanin reductase activity
HG264_RS07670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HG264_RS07675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG264_RS07680	COG0585	pseudouridine synthase activity
HG264_RS07695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HG264_RS07715	COG4191	Histidine kinase
HG264_RS07720	COG2204	response regulator
HG264_RS07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG264_RS07730	COG0577	efflux transmembrane transporter activity
HG264_RS07730	COG1136	(ABC) transporter
HG264_RS07750	COG2267	carboxylic ester hydrolase activity
HG264_RS07755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HG264_RS07760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG264_RS07775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG264_RS07780	COG0662	Cupin 2, conserved barrel domain protein
HG264_RS07785	COG5285	phytanoyl-CoA dioxygenase
HG264_RS07790	COG0527	aspartate kinase activity
HG264_RS07805	COG0180	Tryptophanyl-tRNA synthetase
HG264_RS07820	COG1684	flagellar biosynthetic protein fliR
HG264_RS07825	COG1987	bacterial-type flagellum assembly
HG264_RS07865	COG0745	RESPONSE REGULATOR receiver
HG264_RS07915	COG5002	protein histidine kinase activity
HG264_RS07935	COG1516	flagellar protein fliS
HG264_RS07950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HG264_RS07970	COG0753	catalase activity
HG264_RS08005	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HG264_RS08015	COG3639	organic phosphonate transmembrane transporter activity
HG264_RS08060	COG2885	chlorophyll binding
HG264_RS08095	COG3501	Rhs element vgr protein
HG264_RS08105	COG1320	monovalent cation:proton antiporter activity
HG264_RS08110	COG2212	antiporter activity
HG264_RS08115	COG1863	multisubunit Na H antiporter MnhE subunit
HG264_RS08120	COG0651	ATP synthesis coupled electron transport
HG264_RS08125	COG1006	Multisubunit Na H antiporter MnhC subunit
HG264_RS08130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG264_RS08130	COG2111	Na H antiporter
HG264_RS08140	COG2212	antiporter activity
HG264_RS08155	COG1006	Multisubunit Na H antiporter MnhC subunit
HG264_RS08160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG264_RS08160	COG2111	Na H antiporter
HG264_RS08190	COG2135	peptidase activity
HG264_RS08225	COG2264	protein methyltransferase activity
HG264_RS08230	COG0121	glutamine amidotransferase
HG264_RS08240	COG2119	membrane
HG264_RS08245	COG2813	Specifically methylates the guanine in position
HG264_RS08250	COG1643	Atp-dependent helicase
HG264_RS08265	COG1522	sequence-specific DNA binding
HG264_RS08275	COG1960	acyl-CoA dehydrogenase activity
HG264_RS08315	COG1304	FMN binding
HG264_RS08330	COG0351	phosphomethylpyrimidine kinase
HG264_RS08335	COG0352	thiamine-phosphate diphosphorylase activity
HG264_RS08340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HG264_RS08365	COG1702	phosphate starvation-inducible protein PhoH
HG264_RS08370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG264_RS08375	COG4535	Mg2 and Co2 transporter CorC
HG264_RS08380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG264_RS08390	COG0495	leucyl-tRNA aminoacylation
HG264_RS08405	COG0589	response to stress
HG264_RS08410	COG0659	secondary active sulfate transmembrane transporter activity
HG264_RS08415	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HG264_RS08430	COG2951	lytic endotransglycosylase activity
HG264_RS08435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG264_RS08440	COG0321	lipoyl(octanoyl) transferase activity
HG264_RS08445	COG2921	Belongs to the UPF0250 family
HG264_RS08450	COG1686	Belongs to the peptidase S11 family
HG264_RS08460	COG2951	lytic endotransglycosylase activity
HG264_RS08465	COG0772	Belongs to the SEDS family
HG264_RS08470	COG0768	penicillin binding
HG264_RS08475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HG264_RS08485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG264_RS08490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG264_RS08500	COG0586	Pfam SNARE associated Golgi protein
HG264_RS08525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HG264_RS08530	COG0205	6-phosphofructokinase activity
HG264_RS08540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG264_RS08545	COG0534	Mate efflux family protein
HG264_RS08550	COG0023	Translation Initiation Factor
HG264_RS08570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HG264_RS08610	COG0151	Belongs to the GarS family
HG264_RS08615	COG2205	protein histidine kinase activity
HG264_RS08615	COG0784	Response regulator, receiver
HG264_RS08615	COG5002	protein histidine kinase activity
HG264_RS08625	COG0305	Participates in initiation and elongation during chromosome replication
HG264_RS08630	COG0359	binds to the 23S rRNA
HG264_RS08640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG264_RS08655	COG0557	exoribonuclease II activity
HG264_RS08670	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HG264_RS08680	COG0330	HflC and HflK could
HG264_RS08685	COG0330	HflC and HflK could
HG264_RS08690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG264_RS08695	COG1923	regulation of RNA biosynthetic process
HG264_RS08700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG264_RS08705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG264_RS08710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG264_RS08715	COG0802	atpase or kinase
HG264_RS08720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG264_RS08720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG264_RS08735	COG1162	GTPase activity
HG264_RS08755	COG0688	phosphatidylethanolamine metabolic process
HG264_RS08760	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HG264_RS08765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG264_RS08770	COG1509	lysine 2,3-aminomutase activity
HG264_RS08810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG264_RS08820	COG2072	flavoprotein involved in K transport
HG264_RS08825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HG264_RS08835	COG0494	nUDIX hydrolase
HG264_RS08845	COG1538	Outer membrane efflux protein
HG264_RS08850	COG1519	Transferase
HG264_RS08860	COG0667	Aldo Keto reductase
HG264_RS08875	COG1132	(ABC) transporter
HG264_RS08890	COG0463	Glycosyl transferase, family 2
HG264_RS08900	COG0438	transferase activity, transferring glycosyl groups
HG264_RS08905	COG0438	transferase activity, transferring glycosyl groups
HG264_RS08930	COG0438	transferase activity, transferring glycosyl groups
HG264_RS08935	COG0859	PFAM glycosyl transferase family 9
HG264_RS08940	COG0859	PFAM glycosyl transferase family 9
HG264_RS09010	COG0579	oxidoreductase
HG264_RS09025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG264_RS09025	COG2755	lipolytic protein G-D-S-L family
HG264_RS09035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HG264_RS09045	COG0488	(ABC) transporter
HG264_RS09050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG264_RS09070	COG2813	Specifically methylates the guanine in position
HG264_RS09075	COG1067	ATP-dependent peptidase activity
HG264_RS09080	COG1587	Uroporphyrinogen-III synthase
HG264_RS09115	COG0840	transmembrane signaling receptor activity
HG264_RS09120	COG1063	alcohol dehydrogenase
HG264_RS09165	COG4969	Belongs to the N-Me-Phe pilin family
HG264_RS09195	COG0352	thiamine-phosphate diphosphorylase activity
HG264_RS09200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG264_RS09205	COG1047	Peptidyl-prolyl cis-trans
HG264_RS09210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG264_RS09215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HG264_RS09220	COG0196	riboflavin kinase activity
HG264_RS09225	COG0728	peptidoglycan biosynthetic process
HG264_RS09230	COG0268	Binds directly to 16S ribosomal RNA
HG264_RS09235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HG264_RS09245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG264_RS09250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG264_RS09255	COG0142	geranyltranstransferase activity
HG264_RS09260	COG0545	Peptidyl-prolyl cis-trans isomerase
HG264_RS09265	COG2252	PERMEase
HG264_RS09450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG264_RS09460	COG0739	heme binding
HG264_RS09490	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG264_RS09500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG264_RS09505	COG0772	Belongs to the SEDS family
HG264_RS09510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG264_RS09515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG264_RS09520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG264_RS09540	COG0275	rRNA processing
HG264_RS09560	COG3107	peptidoglycan biosynthetic process
HG264_RS09565	COG0792	nuclease activity
HG264_RS09580	COG2969	positive regulation of protein catabolic process
HG264_RS09585	COG0625	glutathione transferase activity
HG264_RS09590	COG2857	Cytochrome c1
HG264_RS09595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG264_RS09600	COG0723	plastoquinol--plastocyanin reductase activity
HG264_RS09605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG264_RS09610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HG264_RS09615	COG0667	Aldo Keto reductase
HG264_RS09620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG264_RS09635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG264_RS09640	COG1127	ABC transporter
HG264_RS09655	COG2755	lipolytic protein G-D-S-L family
HG264_RS09655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG264_RS09665	COG1748	Saccharopine dehydrogenase
HG264_RS09675	COG0519	Catalyzes the synthesis of GMP from XMP
HG264_RS09675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG264_RS09685	COG1570	exodeoxyribonuclease VII activity
HG264_RS09690	COG0739	heme binding
HG264_RS09695	COG0668	transmembrane transport
HG264_RS09700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG264_RS09710	COG1160	GTP binding
HG264_RS09720	COG2976	Protein conserved in bacteria
HG264_RS09725	COG0124	histidyl-tRNA synthetase
HG264_RS09730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HG264_RS09750	COG0105	UTP biosynthetic process
HG264_RS09755	COG1104	cysteine desulfurase activity
HG264_RS09760	COG1045	serine acetyltransferase
HG264_RS09785	COG1862	Preprotein translocase
HG264_RS09790	COG0343	queuine tRNA-ribosyltransferase activity
HG264_RS09810	COG0204	Acyl-transferase
HG264_RS09815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG264_RS09820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG264_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS09920	COG0492	ferredoxin-NADP+ reductase activity
HG264_RS09925	COG0450	alkyl hydroperoxide reductase
HG264_RS09930	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HG264_RS09950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HG264_RS09960	COG0204	Acyl-transferase
HG264_RS09965	COG2885	chlorophyll binding
HG264_RS09970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG264_RS09975	COG2852	Protein conserved in bacteria
HG264_RS09980	COG1301	dicarboxylic acid transport
HG264_RS09995	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS10000	COG0183	Belongs to the thiolase family
HG264_RS10015	COG0840	transmembrane signaling receptor activity
HG264_RS10020	COG4977	sequence-specific DNA binding
HG264_RS10025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG264_RS10070	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS10080	COG5002	protein histidine kinase activity
HG264_RS10080	COG5001	Diguanylate cyclase
HG264_RS10085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HG264_RS10090	COG0084	hydrolase, TatD family'
HG264_RS10100	COG0300	oxidoreductase activity
HG264_RS10115	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HG264_RS10120	COG4191	Histidine kinase
HG264_RS10145	COG1252	NADH dehydrogenase
HG264_RS10170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG264_RS10180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG264_RS10185	COG0189	ligase activity
HG264_RS10185	COG4067	protein conserved in archaea
HG264_RS10205	COG1011	Hydrolase
HG264_RS10210	COG0494	nUDIX hydrolase
HG264_RS10220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG264_RS10225	COG2111	Na H antiporter
HG264_RS10225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HG264_RS10230	COG1006	Multisubunit Na H antiporter MnhC subunit
HG264_RS10235	COG0651	ATP synthesis coupled electron transport
HG264_RS10240	COG1863	multisubunit Na H antiporter MnhE subunit
HG264_RS10245	COG2212	antiporter activity
HG264_RS10250	COG1320	monovalent cation:proton antiporter activity
HG264_RS10255	COG0697	spore germination
HG264_RS10260	COG0628	permease
HG264_RS10280	COG3268	Saccharopine dehydrogenase
HG264_RS10285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HG264_RS10290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG264_RS10295	COG3025	triphosphatase activity
HG264_RS10300	COG1392	Phosphate transport regulator
HG264_RS10305	COG0306	phosphate transporter
HG264_RS10315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG264_RS10320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG264_RS10320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HG264_RS10325	COG0129	dihydroxy-acid dehydratase activity
HG264_RS10330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HG264_RS10335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HG264_RS10340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG264_RS10345	COG0730	response to heat
HG264_RS10355	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HG264_RS10360	COG0494	nUDIX hydrolase
HG264_RS10365	COG0560	Phosphoserine phosphatase
HG264_RS10375	COG3830	Belongs to the UPF0237 family
HG264_RS10385	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS10395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG264_RS10400	COG0431	NADPH-dependent FMN reductase
HG264_RS10405	COG2239	Acts as a magnesium transporter
HG264_RS10410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG264_RS10410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG264_RS10415	COG0509	glycine decarboxylation via glycine cleavage system
HG264_RS10425	COG1178	ABC-type Fe3 transport system permease component
HG264_RS10435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG264_RS10440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG264_RS10445	COG0006	proline dipeptidase activity
HG264_RS10470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG264_RS10480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HG264_RS10485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HG264_RS10495	COG0179	Fumarylacetoacetate (FAA) hydrolase
HG264_RS10500	COG0277	FAD linked oxidase domain protein
HG264_RS10505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG264_RS10510	COG1683	Conserved Protein
HG264_RS10525	COG2267	carboxylic ester hydrolase activity
HG264_RS10540	COG0745	RESPONSE REGULATOR receiver
HG264_RS10565	COG4771	TonB-dependent receptor
HG264_RS10570	COG0625	glutathione transferase activity
HG264_RS10580	COG2076	Multidrug Resistance protein
HG264_RS10605	COG2755	lipolytic protein G-D-S-L family
HG264_RS10605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HG264_RS10615	COG2962	Rard protein
HG264_RS10630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG264_RS10635	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HG264_RS10720	COG0483	inositol monophosphate 1-phosphatase activity
HG264_RS10750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG264_RS10775	COG0058	SHG alpha-glucan phosphorylase activity
HG264_RS10780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HG264_RS10785	COG0840	transmembrane signaling receptor activity
HG264_RS10800	COG0840	transmembrane signaling receptor activity
HG264_RS10820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HG264_RS10830	COG4628	conserved protein (DUF2132)
HG264_RS10835	COG0724	RNA recognition motif
HG264_RS10845	COG2081	HI0933 family
HG264_RS10855	COG0745	RESPONSE REGULATOR receiver
HG264_RS10860	COG3706	GGDEF domain
HG264_RS10865	COG0513	Belongs to the DEAD box helicase family
HG264_RS10870	COG0471	metal ion transport
HG264_RS10870	COG3273	potassium ion transport
HG264_RS10885	COG2133	pyrroloquinoline quinone binding
HG264_RS10900	COG0191	fructose-bisphosphate aldolase activity
HG264_RS10905	COG0126	phosphoglycerate kinase activity
HG264_RS10910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HG264_RS10920	COG2226	methyltransferase
HG264_RS10925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG264_RS10935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG264_RS10940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HG264_RS10945	COG0513	Belongs to the DEAD box helicase family
HG264_RS10960	COG1960	acyl-CoA dehydrogenase activity
HG264_RS10965	COG0583	DNA-binding transcription factor activity
HG264_RS10970	COG4604	ABC transporter, ATP-binding protein
HG264_RS10975	COG4605	iron ion homeostasis
HG264_RS10980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG264_RS10985	COG4607	ABC-type enterochelin transport system periplasmic component
HG264_RS10990	COG2353	YceI-like domain
HG264_RS10995	COG3038	cytochrome b561
HG264_RS11000	COG0134	indole-3-glycerol-phosphate synthase activity
HG264_RS11005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG264_RS11010	COG0512	Glutamine amidotransferase of anthranilate synthase
HG264_RS11025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HG264_RS11030	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HG264_RS11035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG264_RS11045	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG264_RS11055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HG264_RS11065	COG2967	ApaG domain
HG264_RS11070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HG264_RS11075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG264_RS11080	COG2766	serine protein kinase
HG264_RS11090	COG2719	SpoVR family
HG264_RS11095	COG0617	tRNA 3'-terminal CCA addition
HG264_RS11105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HG264_RS11115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG264_RS11120	COG1307	EDD domain protein, DegV family
HG264_RS11130	COG0358	DNA primase activity
HG264_RS11150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HG264_RS11155	COG0829	nickel cation binding
HG264_RS11160	COG0831	urea catabolic process
HG264_RS11165	COG0832	Belongs to the urease beta subunit family
HG264_RS11170	COG0804	urea catabolic process
HG264_RS11175	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HG264_RS11180	COG0830	nickel cation binding
HG264_RS11185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HG264_RS11195	COG3938	Belongs to the proline racemase family
HG264_RS11215	COG4181	ATPase activity
HG264_RS11220	COG1960	acyl-CoA dehydrogenase activity
HG264_RS11225	COG1960	acyl-CoA dehydrogenase activity
HG264_RS11230	COG3273	potassium ion transport
HG264_RS11230	COG0471	metal ion transport
HG264_RS11235	COG2873	o-acetylhomoserine
HG264_RS11240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG264_RS11245	COG0493	'glutamate synthase
HG264_RS11250	COG0067	glutamate synthase
HG264_RS11250	COG0070	glutamate synthase
HG264_RS11250	COG0069	glutamate synthase activity
HG264_RS11260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG264_RS11265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG264_RS11305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HG264_RS11310	COG4988	ABC transporter
HG264_RS11315	COG1294	oxidase, subunit
HG264_RS11320	COG1271	oxidase subunit
HG264_RS11325	COG1346	cytolysis
HG264_RS11345	COG1960	acyl-CoA dehydrogenase activity
HG264_RS11365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HG264_RS11390	COG0784	Response regulator, receiver
HG264_RS11390	COG4191	Histidine kinase
HG264_RS11410	COG0668	transmembrane transport
HG264_RS11460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HG264_RS11465	COG0406	alpha-ribazole phosphatase activity
HG264_RS11470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HG264_RS11480	COG1492	cobalamin metabolic process
HG264_RS11495	COG0778	Nitroreductase
HG264_RS11500	COG1797	cobyrinic acid a,c-diamide synthase activity
HG264_RS11515	COG4206	TonB-dependent receptor
HG264_RS11530	COG3257	ureidoglycine aminohydrolase activity
HG264_RS11555	COG1253	flavin adenine dinucleotide binding
HG264_RS11565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HG264_RS11575	COG5002	protein histidine kinase activity
HG264_RS11580	COG1715	Restriction endonuclease
HG264_RS11650	COG0697	spore germination
HG264_RS11665	COG1194	a g-specific adenine glycosylase
HG264_RS11675	COG0579	oxidoreductase
HG264_RS11680	COG0131	Imidazoleglycerol-phosphate dehydratase
HG264_RS11685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG264_RS11695	COG0107	imidazoleglycerol-phosphate synthase activity
HG264_RS11700	COG2861	carbohydrate metabolic process
HG264_RS11705	COG0793	Belongs to the peptidase S41A family
HG264_RS11710	COG4942	peptidase
HG264_RS11720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG264_RS11730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HG264_RS11735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HG264_RS11755	COG0488	(ABC) transporter
HG264_RS11760	COG1671	Belongs to the UPF0178 family
HG264_RS11770	COG3706	GGDEF domain
HG264_RS11785	COG0248	Ppx GppA phosphatase
HG264_RS11800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HG264_RS11815	COG3071	HemY protein
HG264_RS11830	COG0181	hydroxymethylbilane synthase activity
HG264_RS11840	COG2972	Histidine kinase
HG264_RS11840	COG0745	RESPONSE REGULATOR receiver
HG264_RS11845	COG0165	Argininosuccinate lyase
HG264_RS11860	COG2957	Belongs to the agmatine deiminase family
HG264_RS11885	COG0174	glutamine synthetase
HG264_RS11890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG264_RS11895	COG0174	glutamine synthetase
HG264_RS11910	COG3842	ATPase activity
HG264_RS11915	COG1176	ABC-type spermidine putrescine transport system, permease component I
HG264_RS11920	COG1177	transmembrane transport
HG264_RS11925	COG1309	transcriptional regulator
HG264_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS11960	COG0330	HflC and HflK could
HG264_RS11995	COG1846	Transcriptional regulator
HG264_RS12000	COG0367	asparagine synthase
HG264_RS12005	COG2918	glutathione biosynthetic process
HG264_RS12005	COG0189	ligase activity
HG264_RS12010	COG1363	Peptidase, m42
HG264_RS12015	COG4772	TonB-dependent receptor
HG264_RS12040	COG1454	alcohol dehydrogenase
HG264_RS12055	COG1024	Enoyl-CoA hydratase
HG264_RS12060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG264_RS12075	COG2363	Small membrane protein
HG264_RS12080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG264_RS12085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG264_RS12110	COG2177	Part of the ABC transporter FtsEX involved in
HG264_RS12115	COG2884	Cell division ATP-binding protein ftsE
HG264_RS12120	COG0552	protein localization to endoplasmic reticulum
HG264_RS12125	COG0612	Peptidase, M16
HG264_RS12130	COG0612	Peptidase, M16
HG264_RS12135	COG0742	ribosomal rna small subunit methyltransferase
HG264_RS12150	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HG264_RS12155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG264_RS12160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HG264_RS12180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG264_RS12195	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG264_RS12200	COG0183	Belongs to the thiolase family
HG264_RS12220	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS12230	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG264_RS12230	COG1024	Enoyl-CoA hydratase
HG264_RS12235	COG1960	acyl-CoA dehydrogenase activity
HG264_RS12255	COG3180	Ammonia monooxygenase
HG264_RS12265	COG1968	undecaprenyl-diphosphatase activity
HG264_RS12300	COG4067	protein conserved in archaea
HG264_RS12300	COG0189	ligase activity
HG264_RS12305	COG2020	methyltransferase activity
HG264_RS12325	COG0739	heme binding
HG264_RS12330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG264_RS12335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG264_RS12340	COG2003	Belongs to the UPF0758 family
HG264_RS12350	COG0756	dUTP diphosphatase activity
HG264_RS12360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG264_RS12390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG264_RS12395	COG1561	YicC-like family, N-terminal region
HG264_RS12400	COG2272	Belongs to the type-B carboxylesterase lipase family
HG264_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS12430	COG0583	DNA-binding transcription factor activity
HG264_RS12440	COG1758	RNA polymerase activity
HG264_RS12445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG264_RS12455	COG1764	response to oxidative stress
HG264_RS12470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG264_RS12495	COG3161	chorismate lyase activity
HG264_RS12530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG264_RS12535	COG0573	inorganic phosphate transmembrane transporter activity
HG264_RS12540	COG0581	inorganic phosphate transmembrane transporter activity
HG264_RS12545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG264_RS12550	COG0704	Plays a role in the regulation of phosphate uptake
HG264_RS12555	COG1607	acyl-coa hydrolase
HG264_RS12560	COG0210	DNA helicase
HG264_RS12570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HG264_RS12575	COG1737	Transcriptional regulator
HG264_RS12585	COG3791	Glutathione-dependent formaldehyde-activating
HG264_RS12595	COG2996	Protein conserved in bacteria
HG264_RS12620	COG0784	Response regulator, receiver
HG264_RS12625	COG1940	carbohydrate kinase activity
HG264_RS12630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG264_RS12655	COG2217	Heavy metal translocating P-type atpase
HG264_RS12660	COG0693	protein deglycase activity
HG264_RS12670	COG3008	intermembrane lipid transfer
HG264_RS12670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HG264_RS12675	COG2995	paraquat-inducible protein a
HG264_RS12680	COG2995	paraquat-inducible protein a
HG264_RS12700	COG0386	Belongs to the glutathione peroxidase family
HG264_RS12715	COG2146	nitrite reductase [NAD(P)H] activity
HG264_RS12715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG264_RS12720	COG2146	nitrite reductase [NAD(P)H] activity
HG264_RS12720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG264_RS12725	COG2116	formate transmembrane transporter activity
HG264_RS12730	COG2815	serine threonine protein kinase
HG264_RS12730	COG0515	serine threonine protein kinase
HG264_RS12770	COG3300	MHYT domain
HG264_RS12770	COG5001	Diguanylate cyclase
HG264_RS12805	COG5642	Protein of unknown function (DUF2384)
HG264_RS12820	COG0488	(ABC) transporter
HG264_RS12850	COG1929	Belongs to the glycerate kinase type-1 family
HG264_RS12855	COG2610	gluconate transmembrane transporter activity
HG264_RS12865	COG0439	Biotin carboxylase
HG264_RS12870	COG5016	pyruvate
HG264_RS12870	COG0511	ligase activity, forming carbon-carbon bonds
HG264_RS12890	COG2130	NADP-dependent
HG264_RS12895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HG264_RS12900	COG0339	signal peptide processing
HG264_RS12905	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HG264_RS12915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG264_RS12920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG264_RS12925	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HG264_RS12950	COG1612	heme a metabolic process
HG264_RS12955	COG0109	protoheme IX farnesyltransferase activity
HG264_RS13010	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HG264_RS13040	COG3813	Protein conserved in bacteria
HG264_RS13075	COG1201	RNA secondary structure unwinding
HG264_RS13080	COG1793	dna ligase
HG264_RS13085	COG1793	dna ligase
HG264_RS13085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG264_RS13090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG264_RS13095	COG1121	(ABC) transporter
HG264_RS13100	COG0735	belongs to the Fur family
HG264_RS13105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HG264_RS13125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG264_RS13145	COG3023	N-Acetylmuramoyl-L-alanine amidase
HG264_RS13150	COG0700	Nucleoside recognition
HG264_RS13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG264_RS13170	COG1396	sequence-specific DNA binding
HG264_RS13170	COG1917	Cupin 2, conserved barrel domain protein
HG264_RS13190	COG3118	belongs to the thioredoxin family
HG264_RS13190	COG0492	ferredoxin-NADP+ reductase activity
HG264_RS13225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HG264_RS13230	COG1984	allophanate hydrolase subunit 2
HG264_RS13235	COG0579	oxidoreductase
HG264_RS13260	COG1620	l-lactate permease
HG264_RS13265	COG2186	Transcriptional regulator
HG264_RS13270	COG3291	Pkd domain containing protein
HG264_RS13270	COG5520	Belongs to the glycosyl hydrolase 30 family
HG264_RS13270	COG4447	cellulose binding
HG264_RS13290	COG3909	cytochrome
HG264_RS13295	COG0659	secondary active sulfate transmembrane transporter activity
HG264_RS13300	COG0583	DNA-binding transcription factor activity
HG264_RS13305	COG0435	Glutathione S-transferase
HG264_RS13315	COG0655	NAD(P)H dehydrogenase (quinone) activity
HG264_RS13320	COG2259	Doxx family
HG264_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS13340	COG5002	protein histidine kinase activity
HG264_RS13385	COG0028	Belongs to the TPP enzyme family
HG264_RS13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HG264_RS13405	COG1024	Enoyl-CoA hydratase
HG264_RS13410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HG264_RS13415	COG1960	acyl-CoA dehydrogenase activity
HG264_RS13420	COG0604	alcohol dehydrogenase
HG264_RS13440	COG0159	tryptophan synthase activity
HG264_RS13445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG264_RS13455	COG0009	L-threonylcarbamoyladenylate synthase
HG264_RS13460	COG0758	DNA mediated transformation
HG264_RS13465	COG1652	LysM domain
HG264_RS13480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG264_RS13485	COG0569	domain protein
HG264_RS13490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HG264_RS13505	COG2818	Glycosylase
HG264_RS13520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HG264_RS13545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG264_RS13555	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG264_RS13560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HG264_RS13565	COG0594	ribonuclease P activity
HG264_RS13570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HG264_RS13575	COG0706	membrane insertase activity
HG264_RS13580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG264_RS13600	COG1192	Involved in chromosome partitioning
HG264_RS13605	COG1475	DNA binding
HG264_RS13610	COG3312	ion transport
HG264_RS13615	COG0356	it plays a direct role in the translocation of protons across the membrane
HG264_RS13625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG264_RS13630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG264_RS13650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG264_RS13655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG264_RS13660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG264_RS13680	COG2814	Major facilitator Superfamily
HG264_RS13685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HG264_RS13690	COG1960	acyl-CoA dehydrogenase activity
HG264_RS13705	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS13720	COG1024	Enoyl-CoA hydratase
HG264_RS13725	COG1960	acyl-CoA dehydrogenase activity
HG264_RS13730	COG1960	acyl-CoA dehydrogenase activity
HG264_RS13755	COG1960	acyl-CoA dehydrogenase activity
HG264_RS13760	COG2030	dehydratase
HG264_RS13765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG264_RS13775	COG2301	Belongs to the HpcH HpaI aldolase family
HG264_RS13810	COG0523	cobalamin synthesis protein
HG264_RS13835	COG0798	PFAM Bile acid sodium symporter
HG264_RS13840	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS13900	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HG264_RS13910	COG4106	trans-aconitate 2-methyltransferase activity
HG264_RS13925	COG1566	PFAM secretion protein HlyD family protein
HG264_RS13930	COG2814	Major facilitator Superfamily
HG264_RS14005	COG0084	hydrolase, TatD family'
HG264_RS14010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG264_RS14025	COG2801	Transposase and inactivated derivatives
HG264_RS14035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HG264_RS14055	COG0640	Transcriptional regulator
HG264_RS14065	COG0431	NADPH-dependent FMN reductase
HG264_RS14070	COG0798	PFAM Bile acid sodium symporter
HG264_RS14105	COG0582	viral genome integration into host DNA
HG264_RS14120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG264_RS14140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG264_RS14145	COG1401	restriction endodeoxyribonuclease activity
HG264_RS14180	COG0606	chelatase, subunit chli
HG264_RS14235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG264_RS14245	COG2963	transposase activity
HG264_RS14255	COG2135	peptidase activity
HG264_RS14260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HG264_RS14265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG264_RS14305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG264_RS14310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG264_RS14345	COG4974	Belongs to the 'phage' integrase family
HG264_RS14395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HG264_RS14420	COG1357	PFAM Pentapeptide repeats (8 copies)
HG264_RS14515	COG0347	Belongs to the P(II) protein family
HG264_RS14520	COG0004	ammonium transporteR
HG264_RS14525	COG0432	Pfam Uncharacterised protein family UPF0047
HG264_RS14540	COG1011	Hydrolase
HG264_RS14570	COG1965	Belongs to the frataxin family
HG264_RS14580	COG0625	glutathione transferase activity
HG264_RS14585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG264_RS14600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG264_RS14600	COG2813	Specifically methylates the guanine in position
HG264_RS14605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG264_RS14610	COG1872	DUF167
HG264_RS14645	COG0540	Belongs to the ATCase OTCase family
HG264_RS14650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HG264_RS14655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG264_RS14660	COG1678	Uncharacterized ACR, COG1678
HG264_RS14670	COG0189	ligase activity
HG264_RS14700	COG0643	Histidine kinase
HG264_RS14700	COG0784	Response regulator, receiver
HG264_RS14700	COG2198	Histidine kinase
HG264_RS14715	COG2205	protein histidine kinase activity
HG264_RS14720	COG0745	RESPONSE REGULATOR receiver
HG264_RS14725	COG2183	response to ionizing radiation
HG264_RS14735	COG2918	glutathione biosynthetic process
HG264_RS14750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG264_RS14760	COG3852	Histidine kinase
HG264_RS14830	COG1490	D-aminoacyl-tRNA deacylase activity
HG264_RS14860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG264_RS14865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG264_RS14870	COG0140	phosphoribosyl-ATP diphosphatase activity
HG264_RS14875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HG264_RS14890	COG2226	methyltransferase
HG264_RS14925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HG264_RS14930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG264_RS14945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG264_RS14960	COG0281	malic enzyme
HG264_RS14970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG264_RS15045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG264_RS15070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG264_RS15095	COG0081	regulation of translation
HG264_RS15105	COG0222	ribosome binding
HG264_RS15110	COG0085	RNA polymerase activity
HG264_RS15120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HG264_RS15125	COG0049	tRNA binding
HG264_RS15130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG264_RS15140	COG0051	transcription antitermination factor activity, RNA binding
HG264_RS15145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG264_RS15150	COG0088	Forms part of the polypeptide exit tunnel
HG264_RS15155	COG0089	rRNA binding
HG264_RS15160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG264_RS15165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG264_RS15170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG264_RS15175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG264_RS15180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG264_RS15185	COG0255	Belongs to the universal ribosomal protein uL29 family
HG264_RS15195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG264_RS15200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG264_RS15205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG264_RS15215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG264_RS15220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG264_RS15225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG264_RS15230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG264_RS15240	COG0200	Binds to the 23S rRNA
HG264_RS15250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HG264_RS15260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HG264_RS15265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG264_RS15270	COG0202	RNA polymerase activity
HG264_RS15280	COG0753	catalase activity
HG264_RS15285	COG2272	Belongs to the type-B carboxylesterase lipase family
HG264_RS15295	COG2814	Major facilitator Superfamily
HG264_RS15315	COG3047	cAMP biosynthetic process
HG264_RS15325	COG0811	peptide transport
HG264_RS15330	COG0811	peptide transport
HG264_RS15335	COG0848	biopolymer transport protein
HG264_RS15350	COG3118	belongs to the thioredoxin family
HG264_RS15355	COG2264	protein methyltransferase activity
HG264_RS15365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG264_RS15365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG264_RS15370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HG264_RS15385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HG264_RS15395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HG264_RS15400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG264_RS15405	COG3577	Aspartyl protease
HG264_RS15410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG264_RS15420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HG264_RS15430	COG4206	TonB-dependent receptor
HG264_RS15440	COG0142	geranyltranstransferase activity
HG264_RS15445	COG1722	exodeoxyribonuclease VII activity
HG264_RS15450	COG0730	response to heat
HG264_RS15455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG264_RS15470	COG1765	OsmC-like protein
HG264_RS15475	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HG264_RS15480	COG0537	adenosine 5'-monophosphoramidase activity
HG264_RS15505	COG0316	Belongs to the HesB IscA family
HG264_RS15515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HG264_RS15520	COG0739	heme binding
HG264_RS15525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG264_RS15560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HG264_RS15565	COG4208	sulfate ABC transporter
HG264_RS15570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HG264_RS15580	COG0019	diaminopimelate decarboxylase activity
HG264_RS15595	COG1360	Flagellar Motor Protein
HG264_RS15600	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HG264_RS15605	COG1074	ATP-dependent DNA helicase activity
HG264_RS15610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG264_RS15615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG264_RS15625	COG0405	Gamma-glutamyltransferase
HG264_RS15635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HG264_RS15665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG264_RS15690	COG1051	belongs to the nudix hydrolase family
HG264_RS15695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG264_RS15720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HG264_RS15730	COG0489	protein tyrosine kinase activity
HG264_RS15755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HG264_RS15765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG264_RS15770	COG0733	neurotransmitter:sodium symporter activity
HG264_RS15795	COG0497	DNA recombination
HG264_RS15800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG264_RS15815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG264_RS15825	COG0505	Belongs to the CarA family
HG264_RS15830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG264_RS15850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HG264_RS15855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG264_RS15860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HG264_RS15865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG264_RS15870	COG0149	triose-phosphate isomerase activity
HG264_RS15875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG264_RS15895	COG0195	Participates in both transcription termination and antitermination
HG264_RS15900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG264_RS15905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG264_RS15910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG264_RS15915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG264_RS15920	COG1185	polyribonucleotide nucleotidyltransferase activity
HG264_RS15950	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HG264_RS15965	COG2323	membrane
HG264_RS15975	COG2890	protein-(glutamine-N5) methyltransferase activity
HG264_RS16010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG264_RS16015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG264_RS16035	COG3852	Histidine kinase
HG264_RS16050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HG264_RS16070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG264_RS16075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HG264_RS16100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG264_RS16110	COG3098	single-species biofilm formation
HG264_RS16120	COG0028	Belongs to the TPP enzyme family
HG264_RS16130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG264_RS16135	COG1183	phosphatidylcholine synthase activity
HG264_RS16165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG264_RS16175	COG0456	acetyltransferase
HG264_RS16180	COG0288	reversible hydration of carbon dioxide
HG264_RS16185	COG0697	spore germination
HG264_RS16190	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG264_RS16190	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HG264_RS16190	COG0506	proline dehydrogenase activity
HG264_RS16200	COG0668	transmembrane transport
HG264_RS16215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG264_RS16230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG264_RS16235	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HG264_RS16250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG264_RS16260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HG264_RS16265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HG264_RS16280	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HG264_RS16285	COG1090	epimerase
HG264_RS16290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HG264_RS16295	COG1280	lysine exporter protein (LysE YggA)
HG264_RS16300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG264_RS16335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HG264_RS16345	COG0659	secondary active sulfate transmembrane transporter activity
HG264_RS16365	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG264_RS16365	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HG264_RS16370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG264_RS16375	COG0154	amidase activity
HG264_RS16380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG264_RS16385	COG1077	Cell shape determining protein MreB Mrl
HG264_RS16390	COG1792	Involved in formation and maintenance of cell shape
HG264_RS16405	COG1530	ribonuclease E activity
HG264_RS16415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG264_RS16420	COG0312	modulator of DNA gyrase
HG264_RS16430	COG0252	asparaginase activity
HG264_RS16445	COG1131	(ABC) transporter
HG264_RS16450	COG0842	Transport permease protein
HG264_RS16465	COG0514	ATP-dependent DNA helicase (RecQ)
HG264_RS16470	COG3387	PFAM Glycoside hydrolase 15-related
HG264_RS16475	COG3081	Nucleoid-associated protein
HG264_RS16480	COG0471	metal ion transport
HG264_RS16480	COG0490	domain, Protein
HG264_RS16485	COG2813	Specifically methylates the guanine in position
HG264_RS16535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG264_RS16550	COG1131	(ABC) transporter
HG264_RS16560	COG4120	Belongs to the binding-protein-dependent transport system permease family
HG264_RS16570	COG0525	valine-tRNA ligase activity
HG264_RS16610	COG0443	Heat shock 70 kDa protein
HG264_RS16615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG264_RS16640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HG264_RS16660	COG2808	Putative FMN-binding domain
HG264_RS16665	COG0702	epimerase
HG264_RS16670	COG1451	nucleotide metabolic process
HG264_RS16685	COG0534	Mate efflux family protein
HG264_RS16695	COG0517	IMP dehydrogenase activity
HG264_RS16695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG264_RS16730	COG1396	sequence-specific DNA binding
HG264_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS16755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG264_RS16760	COG0385	Bile acid
HG264_RS16765	COG2072	flavoprotein involved in K transport
HG264_RS16800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG264_RS16825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG264_RS16830	COG0795	lipopolysaccharide-transporting ATPase activity
HG264_RS16835	COG0795	lipopolysaccharide-transporting ATPase activity
HG264_RS16850	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HG264_RS16855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG264_RS16860	COG0477	Major facilitator Superfamily
HG264_RS16865	COG1234	tRNA 3'-trailer cleavage
HG264_RS16890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HG264_RS16925	COG3022	response to hydroperoxide
HG264_RS16930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HG264_RS16945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG264_RS16950	COG3264	Mechanosensitive ion channel
HG264_RS16950	COG1196	nuclear chromosome segregation
HG264_RS16955	COG1960	acyl-CoA dehydrogenase activity
HG264_RS16960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HG264_RS16965	COG1040	competence protein
HG264_RS16970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG264_RS16975	COG0156	8-amino-7-oxononanoate synthase activity
HG264_RS16980	COG1073	alpha beta
HG264_RS16980	COG2226	methyltransferase
HG264_RS17000	COG1960	acyl-CoA dehydrogenase activity
HG264_RS17005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG264_RS17015	COG3028	Belongs to the UPF0307 family
HG264_RS17020	COG0312	modulator of DNA gyrase
HG264_RS17030	COG1660	Displays ATPase and GTPase activities
HG264_RS17050	COG1137	ATPase activity
HG264_RS17055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HG264_RS17065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HG264_RS17075	COG1127	ABC transporter
HG264_RS17080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG264_RS17115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG264_RS17135	COG0175	sulfate reduction
HG264_RS17150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HG264_RS17165	COG3323	Protein of unknown function (DUF1653)
HG264_RS17165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HG264_RS17170	COG1858	cytochrome C peroxidase
HG264_RS17200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HG264_RS17205	COG4536	flavin adenine dinucleotide binding
HG264_RS17215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG264_RS17220	COG0228	four-way junction DNA binding
HG264_RS17225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HG264_RS17230	COG0336	Belongs to the RNA methyltransferase TrmD family
HG264_RS17235	COG0335	large ribosomal subunit rRNA binding
HG264_RS17240	COG4974	Belongs to the 'phage' integrase family
HG264_RS17245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HG264_RS17260	COG3932	Exopolysaccharide synthesis, ExoD
HG264_RS17280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG264_RS17310	COG2943	transferase activity, transferring hexosyl groups
HG264_RS17315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG264_RS17350	COG1285	pathogenesis
HG264_RS17355	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HG264_RS17360	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS17370	COG0366	Alpha amylase catalytic
HG264_RS17375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG264_RS17380	COG0392	lysyltransferase activity
HG264_RS17385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG264_RS17390	COG3568	Endonuclease Exonuclease Phosphatase
HG264_RS17430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG264_RS17435	COG0297	glycogen (starch) synthase activity
HG264_RS17440	COG1058	Belongs to the CinA family
HG264_RS17440	COG1546	Belongs to the CinA family
HG264_RS17450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG264_RS17455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HG264_RS17475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HG264_RS17490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HG264_RS17495	COG1024	Enoyl-CoA hydratase
HG264_RS17545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG264_RS17550	COG0481	GTPase activity
HG264_RS17555	COG0681	Belongs to the peptidase S26 family
HG264_RS17565	COG0571	ribonuclease III activity
HG264_RS17570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HG264_RS17590	COG5002	protein histidine kinase activity
HG264_RS17590	COG0784	Response regulator, receiver
HG264_RS17590	COG2205	protein histidine kinase activity
HG264_RS17605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG264_RS17610	COG3956	TIGRFAM MazG family protein
HG264_RS17620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HG264_RS17640	COG0742	ribosomal rna small subunit methyltransferase
HG264_RS17650	COG1131	(ABC) transporter
HG264_RS17670	COG3118	belongs to the thioredoxin family
HG264_RS17680	COG2226	methyltransferase
HG264_RS17695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HG264_RS17700	COG2171	N-acyltransferase activity
HG264_RS17705	COG1393	Belongs to the ArsC family
HG264_RS17710	COG0436	Aminotransferase
HG264_RS17715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HG264_RS17720	COG0024	Methionine aminopeptidase
HG264_RS17725	COG0052	Belongs to the universal ribosomal protein uS2 family
HG264_RS17730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG264_RS17740	COG0233	cytoplasmic translational termination
HG264_RS17745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG264_RS17775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG264_RS17780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG264_RS17785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG264_RS17790	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG264_RS17795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG264_RS17805	COG0825	malonyl-CoA metabolic process
HG264_RS17810	COG0037	tRNA processing
HG264_RS17815	COG0504	CTP synthase activity
HG264_RS17820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG264_RS17825	COG0148	phosphopyruvate hydratase activity
HG264_RS17835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HG264_RS17850	COG0587	DNA-directed DNA polymerase activity
HG264_RS17855	COG1960	acyl-CoA dehydrogenase activity
HG264_RS17860	COG1024	Enoyl-CoA hydratase
HG264_RS17885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG264_RS17895	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS17900	COG4191	Histidine kinase
HG264_RS17920	COG3706	GGDEF domain
HG264_RS17935	COG2358	TRAP transporter, solute receptor (TAXI family
HG264_RS17940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG264_RS17970	COG3012	SEC-C Motif Domain Protein
HG264_RS17980	COG1199	ATP-dependent helicase activity
HG264_RS17995	COG0300	oxidoreductase activity
HG264_RS18005	COG1946	Acyl-CoA thioesterase
HG264_RS18030	COG1115	amino acid carrier protein
HG264_RS18045	COG3725	Membrane protein required for beta-lactamase induction
HG264_RS18055	COG2096	Adenosyltransferase
HG264_RS18065	COG0745	RESPONSE REGULATOR receiver
HG264_RS18070	COG1666	GTP binding
HG264_RS18075	COG0668	transmembrane transport
HG264_RS18090	COG3695	enzyme binding
HG264_RS18100	COG1028	Short-chain dehydrogenase reductase Sdr
HG264_RS18120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HG264_RS18125	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS18135	COG0840	transmembrane signaling receptor activity
HG264_RS18140	COG3030	protein affecting phage T7 exclusion by the F plasmid
HG264_RS18145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG264_RS18155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG264_RS18165	COG0318	PFAM AMP-dependent synthetase and ligase
HG264_RS18180	COG1309	transcriptional regulator
HG264_RS18185	COG1546	Belongs to the CinA family
HG264_RS18190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG264_RS18195	COG2137	regulation of response to DNA damage stimulus
HG264_RS18205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG264_RS18230	COG0784	Response regulator, receiver
HG264_RS18230	COG2198	Histidine kinase
HG264_RS18230	COG2205	protein histidine kinase activity
HG264_RS18255	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG264_RS18255	COG1024	Enoyl-CoA hydratase
HG264_RS18270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG264_RS18270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG264_RS18280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG264_RS18285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HG264_RS18310	COG0732	type I restriction modification DNA specificity domain
HG264_RS18315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HG264_RS18325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG264_RS18405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress